SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors PIAS4 HDAC4 PIAS3 THRB UBE2I VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 SUMO2 RARA PPARG PGR PPARA SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MINPP1 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA PPIA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes CPS1 ARG1 TP53 OTC GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis AGPAT1 AGPAT2 AGPAT3 SELENOI AGPAT4 AWAT2 GPAT4 GPAT3 GPAT2 CEPT1 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A DDHD2 MBOAT1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A MIGA2 DGAT2 PCYT2 CSNK2A1 DGAT1 MIGA1 STARD7 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 CSNK2B GPD1 PLA2G10 PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLA2G6 PLD1 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB CHKA OSBPL5 STARD10 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP OSBPL10 ACP6 PLA2G4F PLA2G12A PCYT1B PCYT1A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLAAT1 PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PLA2G1B PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling EGF ERBB2 PLCG1 EGFR REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition YWHAE CEP57 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA CEP290 NINL YWHAG RAB8A SKP1 CDK5RAP2 OFD1 HSP90AA1 BORA CEP135 PPP1R12A FBXW11 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 UBA52 AJUBA OPTN PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 UBB HAUS8 PRKAR2B HAUS7 UBC CEP70 CEP72 CEP192 PCNT RPS27A CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members STAT3 BCL2 PMAIP1 BMF BID BBC3 BCL2L1 BCL2L11 BAD DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix PRSS1 COL16A1 COL12A1 CAPN15 CAPN8 CAPN9 CAPN6 CAPNS1 CAPNS2 CDH1 CAPN7 BSG CAPN5 CAPN2 CAPN3 CAPN1 PRSS2 CAST PHYKPL CTRB2 CTRB1 COL23A1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 PSEN1 KLK2 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 CTSV LAMC1 CTSS MMP20 ADAMTS4 ADAMTS5 MMP25 MMP24 CTSL ADAMTS1 CASP3 CTSK TIMP2 CTSG TIMP1 ADAMTS8 TPSAB1 ADAMTS9 CTSD CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 CD44 LAMA5 COL15A1 TMPRSS6 LAMA3 PLG FURIN COL19A1 ACAN SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 TLL1 KLKB1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression EPOP AGPAT2 ERCC3 KANSL1 SCD KANSL2 KANSL3 ERCC2 THRSP ERCC6 ZNF610 GPAM LPIN1 PNPLA2 AJUBA RB1 SMARCB1 CCNH EHMT2 H2AC19 EHMT1 CCNC RRP8 ACTB LIPE H2AC14 TRIM28 H2BC12L SAP130 DPF1 PDK4 DPF2 KAT8 DPF3 MED1 SAP30BP SMARCC1 SMARCC2 ACSL1 MED4 HCFC2 MED6 MED7 HCFC1 WDR82 ZNF28 PAXIP1 ZNF273 PEX11A BAZ2A ZNF708 PPARGC1A PPARGC1B KAT14 ZNF264 CREBBP ZNF141 H4C9 SETDB1 ZNF382 SETD1B SS18L1 SETD1A SMARCA5 SMARCA2 CIDEC SMARCA4 TADA2A ZZZ3 ZNF816 H2AC20 ZNF30 ZNF136 ZNF257 EZH1 EZH2 H2AX PHF20 SUV39H1 PHF1 ASH2L SGF29 MED16 MED17 MED12 MED14 MED13 MED10 CD36 JARID2 H3-3B NCOA1 NCOA2 H3C8 SS18 ELOVL5 NCOA6 NCOA3 ACTL6A TET2 TET1 PPHLN1 BAZ1B MED27 SIRT1 MED23 NCOR2 PHF20L1 KAT2B KAT2A H2AJ MED24 NR5A2 NCOR1 AEBP2 TET3 MED20 MTF2 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H3C15 TBL1X SF3B1 ZNF224 MBD3 SUZ12 H2BC9 H2BC8 H2BC5 MCRS1 H2BC3 MBD2 H2BC1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GATAD2B GATAD2A ZNF33A FABP4 MYBBP1A ZNF354A MPHOSPH8 ZNF454 ZNF331 H2AB1 ARID4B TTF1 EP300 MTREX ZNF324 PHLDA1 MEN1 ZNF320 H2AC8 ZNF680 H2AC6 H2AC7 UBE2I ADIPOQ SAP30 SPOCD1 ZNF93 TBL1XR1 ZNF317 ZCCHC8 KMT2D DNMT1 KMT2A KMT2C RXRA KMT2B BOD1L1 LPL MED30 SUMO2 MED31 TASOR MBIP ZNF669 ABL1 TASP1 ZNF547 ZNF425 SUDS3 MORC2 DR1 CBX5 BOD1 CBX3 EZHIP CDK8 CDK7 CDK5 YEATS2 ZNF418 TADA3 ZNF778 ZNF534 DGAT2 MNAT1 OGT PHF19 GSK3B PIWIL4 AKAP8L PSIP1 DPY30 CHD4 CHD3 PAGR1 DNMT3L H2BC26 SIN3B BCL7A SIN3A ZNF649 H2BC21 BCL7C BCL7B DNMT3B UBTF WDR5 ZNF765 RBM7 KDM6A TBP EED DNMT3A ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 ZNF519 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H CEBPA C19orf84 SMARCD1 ACSS3 HDAC2 SMARCD2 HDAC3 SMARCD3 UHRF1 HDAC1 CXXC1 DDX21 TAF1D MTA1 TAF1B RBBP4 TAF1C RBBP5 TDG SAP30L TAF1A POLR2E POLR2F SAP18 POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L MGLL ATF7IP SMARCE1 H2AZ2 DEK ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B PLA2G2A HTN3 S100A7A BPIFA1 GNLY BPIFA2 PRSS2 EPPIN CCR6 PGLYRP1 ATP7A PRSS3 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 SLC11A1 DEFB116 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 ELANE DEFB4B S100A8 TLR2 S100A7 LTF DEFB103B REG3A DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 CTSG PDZD11 RNASE8 RNASE7 PI3 DEFA1B CHGA DEFB104B DEFA6 DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 CD4 BPIFB2 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 RIPPLY2 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 MESP2 PSMD12 PSMD11 NOTCH1 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 PSMB6 PSMD8 LFNG PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES7 EPHA4 MSGN1 ADRM1 TBX6 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism SLC5A6 PC BTD PCCA HLCS MCCC1 PCCB PDZD11 ACACB ACACA MCCC2 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLC10A6 SLC44A5 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 YWHAB HSPB1 ELAVL1 ZFP36 XPO1 KHSRP AKT1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ XRN1 MAPKAPK2 PABPC1 DCP2 SET ANP32A PARN ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 MAPK14 MAPK11 DCP1A HSPA1A EIF4G1 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 GSK3B BTRC PRKACA SKP1 OFD1 IFT172 GLI1 GLI3 GLI2 IFT52 SUFU PRKACG IFT57 PRKACB DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 RBX1 IFT88 ADCY9 PRKAR1B SMO PRKAR1A GPR161 NUMB UBA52 INTU ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CUL1 KIF3A TTC21B PRKAR2A PSMD12 CSNK1A1 PSMD11 UBB PTCH1 WDR19 PSMD14 PRKAR2B IFT122 PSMD13 FUZ UBC ADCY10 ITCH GNAS PSMA7 MKS1 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN SLC35A1 SLC35A4 FKRP B4GAT1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2AC14 H2BC21 H3-3B H2BC12L H3C8 H2AC8 H2AC6 ERCC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 H4C9 HDAC2 H3C15 MBD3 CBX3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 H2AC20 H2BC1 H2AX GATAD2B GATAD2A RBBP7 CHD4 MTA2 EHMT2 CHD3 MTA3 H2AC19 H2BC26 H2AB1 H2AZ2 TTF1 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs PSMA5 RASA2 CUL3 SEM1 PSMA6 RASAL1 PSMA3 RASAL2 RASAL3 PSMC5 PSMA4 NRAS DAB2IP PSMC6 NF1 PSMC3 KBTBD7 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 SPRED3 PSMD3 SPRED2 PSMB1 SPRED1 PSMD1 SYNGAP1 HRAS RASA3 RASA4 ADRM1 RASA1 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3 GZMM CFB HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle ERCC3 ERCC2 CCNK CCNT2 NUP107 CCNT1 NUP188 GTF2B RCC1 BANF1 KPNA1 SUPT16H LIG1 NUP210 LIG4 GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 POM121 TSG101 SUPT4H1 NEDD4L AAAS GTF2E1 GTF2E2 NUP160 POM121C NUP85 TPR NUP88 XRCC6 XRCC4 NUP155 XRCC5 VTA1 HMGA1 ELOA2 NUP153 SUPT5H CDK9 CHMP2B CHMP2A NMT1 TAF4B NMT2 FEN1 ELL TAF7L NUP62 ELOA NELFB ELOB NELFCD NELFA ELOC CCR5 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 NCBP2 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 CHMP3 UBA52 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CD4 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 TAF1L POLR2A UBB POLR2B NUP42 POLR2C POLR2D UBC MVB12B MVB12A POLR2G NUP43 POLR2I RPS27A TAF9B POLR2J RAE1 GTF2H1 RANBP2 GTF2H2 RANBP1 GTF2H3 RNGTT GTF2H4 TAF15 GTF2H5 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 UBAP1 TAF7 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 RAN TAF2 NUP37 TAF1 PPIA XPO1 NUP214 CDK7 MNAT1 PSIP1 TBP FURIN POLR2E POLR2F POLR2H CCNH POLR2K POLR2L CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation IDUA HEXB NCAN HEXA BGN GLB1L3 GLB1L2 VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 DCN GUSB ARSB BCAN MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes HERC5 IKBKB IFI27 TRIM25 ARIH1 IKBKG ATF6 RIGI FKBP5 CHUK UBA7 HSPA5 IFI6 EIF2AK3 UBE2L6 ISG15 IFI44L IFIH1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling NTRK1 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 AP2S1 DNAL4 SH3GL2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB FRAT1 FRAT2 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib CDC37 ERBIN ERBB2 HSP90AA1 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 STOML2 PHB1 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development CTNNB1 ROBO2 ITGB1 RET FOXC2 FOXC1 SIX1 GATA3 HOXD11 PCDH19 HOXC11 FGF2 WFDC2 HOXA11 PLAC8 WNT11 SALL1 MECOM SIX2 HNF4A SLIT2 HOXA6 DLL1 WNT4 IRX1 IRX2 EMX2 JAG1 LFNG EYA1 OSR1 WNT9B GFRA1 HNF1B NPNT POU3F3 PAX2 BMP4 GREM1 GDNF PAX8 WT1 LHX1 ITGA8 HOXB4 ID4 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK ALK EP300 STAT3 CD274 IRS1 PIK3R2 PTN PIK3CB PIK3R1 PRDM1 IL2RG HIF1A PTPRZ1 MDK MYC ALKAL2 ALKAL1 JAK3 FRS2 MYCN DNMT1 PIK3CA PTPN6 HDAC2 HDAC3 HDAC1 PLCG1 SIN3A FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat ELOA ERCC3 NELFB ELOB NELFCD NELFA ELOC ERCC2 NELFE NCBP1 CCNK CCNT2 NCBP2 CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E GTF2H5 POLR2F ELOA2 POLR2H SUPT5H CDK9 CCNH SSRP1 POLR2K POLR2L TCEA1 ELL REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 CDH11 TNRC6A TNRC6B RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF CBFB EP300 KRAS RUNX3 RUNX1 HDAC4 BRD2 TGFB1 CCND1 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins CYP2C9 CYP2C8 CYP2D6 EPHX2 ALOX5 CYP1A2 CYP2E1 CYP3A4 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants CDC37 ERBIN ERBB2 HSP90AA1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2D TFAP2E KCTD1 KCTD15 SUMO1 UBE2I TFAP2A TFAP2B WWOX TFAP2C TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX VENTX TCF7L2 ANAPC7 UBE2C CDKN2A UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CTNNB1 TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B CCND1 TP53 LEF1 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 EHMT2 ANAPC10 RELA EHMT1 ANAPC11 FZR1 CDC23 CDC26 CDC27 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection PTPN6 YWHAE TLR1 TLR2 YWHAG HSP90AA1 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 UBA52 RPS16 TBK1 RPS19 SNRPD2 RPS18 SNRPD1 AKT2 AKT3 SNRPD3 RPS11 B2M GOLGA7 RPS10 RPS13 UBB VPS39 RPS12 VPS18 HLA-H UBC ST6GAL1 HLA-B HLA-C MOGS HLA-A RPS27A ATG14 HLA-F HLA-G HLA-E ACE2 RPS4Y2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 RPS4Y1 LARP1 VPS11 ST3GAL4 SFN ST3GAL1 ST3GAL2 VPS16 ST3GAL3 SRPK2 EDEM2 PARP16 PARP14 SRPK1 PARP10 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 IFNA5 NRP1 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 MAGT1 YWHAB IFNA8 MAP1LC3B HSPG2 TRIM4 HAVCR1 IKBKE AKT1 JAK1 TOMM70 NUP214 PARP6 PARP4 PRMT1 RIPK2 SFTPD YWHAZ ANO8 ANO9 ANO6 TYK2 ANO7 ZDHHC11 ANO4 PARP9 ANO5 IL17RC ANO2 PARP8 ANO3 IL17RA ANO1 SIKE1 CANX TLR8 TLR7 ZDHHC20 RPS27L TMPRSS2 RNF135 RPS15A GPC1 MGAT5 CTSL RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 RPS2 GPC4 MGAT2 GPC6 STAT1 IFNB1 STAT2 TJP1 NLRP12 STING1 ZDHHC9 IL17F FAU AGRN CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 RPS9 IFNA14 RPS7 RPS8 IFNA16 RPS5 VPS33A CSNK1A1 IFNA17 RPS6 VPS33B FURIN RPSA ZCRB1 TUFM TMEM258 GEMIN4 SNRPG GEMIN5 GEMIN6 SNRPE UBE2V1 GEMIN7 MASP1 SNRPF GEMIN8 ISCU IFNA10 RB1 IFNAR1 SNRPB VCP DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 SMN2 G3BP2 NLRP3 IFNA21 UVRAG OST4 CAV1 MAVS OSTC STT3A UBE2N TAB3 TAB2 TAB1 STT3B NUP107 PALS1 GSK3A NUP188 ST6GALNAC2 HSP90AB1 PRKCSH RPS4X YWHAQ MBL2 YWHAH NUP210 PDPK1 RPS3A DDOST IRF3 NUP93 DAD1 CHMP4C TRAF3 CREBBP CHMP4B TRAF6 CHMP4A IRF7 PIK3C3 NUP205 MAN1B1 POM121 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A AAAS DDX20 NOD1 NOD2 NUP160 GANAB POM121C VHL NUP85 SEC24B TPR SEC24A NUP88 CNBP GALNT1 PTPN11 NUP155 MGAT4C MGAT4A MGAT4B VPS41 VPS45 NUP153 SEC24D SEC24C CHMP2B CHMP2A NUP62 NDC1 SEC13 NUP133 NUP50 CHMP3 NUP54 CHMP6 CHMP7 NUP42 NUP43 RAE1 RANBP2 NUP35 NUP37 UBE2I SUMO1 CHUK ISG15 IFIH1 IKBKB TRIM25 IKBKG RIGI GSK3B TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 CCNK CCNT2 CCNT1 GTF2B SUPT16H GTF2F1 GTF2F2 SUPT4H1 GTF2E1 GTF2E2 CDK7 MNAT1 ELOA2 SUPT5H CDK9 TAF4B ELL TAF7L ELOA NELFB ELOB NELFCD NELFA ELOC NELFE TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 RNMT TAF9 TAF1L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 GTF2H3 RNGTT GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH SSRP1 TAF8 POLR2K POLR2L TAF7 TCEA1 TAF6 TAF5 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels CALM1 SLC8A1 SLC8A2 SLC8A3 ATP2B4 ATP2A3 ATP2A2 ATP2B3 ATP2A1 ATP2B2 ATP2B1 SRI HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRNA5 CHRNA4 CHRNA6 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding TUBA1A GBA1 DCAF7 CCT6B TUBB6 TUBA4A TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 CCNE2 CCNE1 XRN2 GAPDHS FKBP9 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 FBXL5 TUBB4B TUBA8 TUBB4A WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 KIF13A CCT3 CCT2 STAT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 AP3M1 TUBA3E GNA14 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 RGS11 TP53 CSNK2A1 CSNK2A2 CSNK2B HDAC3 ACTB REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins H2AC14 TRIM28 H2BC12L ZNF324 ZNF320 H2AC8 ZNF680 H2AC6 H2AC7 UBE2I ZNF610 ZNF93 ZNF317 ZNF28 ZNF273 SUMO2 ZNF708 ZNF669 ZNF264 ZNF547 ZNF141 ZNF425 H4C9 SETDB1 ZNF382 CBX5 ZNF816 ZNF418 H2AC20 ZNF30 ZNF778 ZNF534 ZNF136 ZNF257 H2AX CHD4 CHD3 H2BC26 ZNF649 H2BC21 H3-3B H3C8 ZNF765 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ZNF519 H2AJ H2BC11 HDAC2 H3C15 ZNF224 MBD3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 H2BC1 GATAD2B GATAD2A ZNF33A RBBP7 MTA2 MTA3 ZNF354A H2AC19 ZNF454 ZNF331 ATF7IP H2AB1 H2AZ2 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG GALE INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing H2AC14 EP300 H2BC12L ST3GAL3 H2AC8 H2AC6 H2AC7 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B CREBBP CCND1 H4C9 TP53 RUNX1 B4GALT1 POGLUT1 MAML2 MAML1 POFUT1 TMED2 PRKCI SIRT6 H2AC20 TFDP1 TFDP2 ELF3 MFNG MAML3 ELANE H2AX NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 ATP2A3 ST3GAL6 ATP2A2 E2F3 RAB6A ATP2A1 H2BC26 JUN NOTCH2NLA NOTCH2NLC NOTCH2NLB SNW1 H2BC21 H3-3B MAMLD1 H3C8 H2BC17 H2BC12 H2BC13 H2BC14 KAT2B H2BC15 KAT2A H2AJ H2BC11 H3C15 NOTCH1 FURIN H2BC9 RBPJ H2BC8 H2BC5 H2BC3 H2BC1 LFNG H2AC19 H2AB1 ST3GAL4 H2AZ2 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 MAPK7 MAP2K5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 STAT3 NRAS HIF1A NR3C1 CCND1 AKT1 EGF ERBB2 EGFR CDKN1B LRRK2 ARHGAP35 RAC1 PELP1 NRG1 ARAP1 NRG2 RHOA EREG BTC DOK1 SFPQ NRG3 NRG4 ELMO1 ELMO2 DOCK1 UBA52 CRK HBEGF KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN CBL SOCS3 CCNE1 GPNMB STAP2 PTPN1 SRMS UBB PTK6 CDK4 CDK2 BCAR1 UBC RPS27A HRAS RASA1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) SUMO1 SUMO3 SUMO2 UBA2 SAE1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism PDZD11 PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC5A6 SLC25A16 NUDT8 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion ACSL4 ACSL3 CD36 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW3 TYW2 TYW1 LCMT2 TYW5 TRMT5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript NXT1 NUP37 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 NUP107 SRRM1 THOC6 NUP188 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 NUP210 SRSF5 SRSF6 SLU7 SRSF7 NUP93 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 NUP205 SRSF1 POM121 U2AF1 NUP214 U2AF1L4 NXF1 U2AF2 AAAS DHX38 SRSF11 CHTOP NUP160 ALYREF POM121C UPF3B NUP85 MAGOHB TPR NXF2B NUP88 RNPS1 NUP155 NUP153 NUP62 NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP50 NUP54 NUP42 NUP43 RAE1 RANBP2 NUP35 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD ABCD1 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPV3 TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation TICAM2 TRADD LY96 TNFRSF10B FASLG TNFRSF10A TRAF2 TICAM1 CASP8 TNFSF10 FAS RIPK1 CD14 FADD TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation UBE2N TAB3 TAB2 TAB1 PDPK1 TRAF6 BTRC UBE2D1 RELA SKP1 FBXW11 NFKB1 UBA52 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 CUL1 IGHV3-30 V3-4 V3-3 PSMD12 V2-17 PSMD11 UBB V3-2 IGHV3-33 PSMD14 V2-15 PSMD13 IGKV1D-39 UBC V2-19 IGKV1D-33 CDC34 PSMA7 IGKV2D-28 IGKV4-1 PSMB6 RPS27A PSMD8 IGHV7-81 PRKCQ CARD11 PSMB7 V1-11 PSMB4 PSMD6 IGKV2D-30 V1-16 PSMB5 PSMD7 V1-13 IGHV4-59 PSMB2 IGHV1-69 PSMB3 PSMD2 BCL10 PSMD3 RASGRP2 RASGRP1 PSMB1 PSMD1 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 ADRM1 IGLV2-14 IGLV1-44 PSMA5 IGKV3-15 SEM1 IGKV3-11 PSMA6 LYN PSMA3 V2-8 PSMC5 V1-20 PSMA4 IGKV2D-40 PSMC6 IGHV3-11 IGHV3-13 PSMC3 IGKV1D-16 PSMA1 IGLV7-43 PSMA2 IGKV1D-12 PSMC4 NFKBIA PSMC1 IGLV1-51 PSMC2 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 CHUK IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IKBKB IGHE IGLV3-19 IGKV2-30 IGHV2-70 IKBKG IGHV2-5 IGLV3-1 IGHV3-48 MALT1 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAP3K7 UBE2V1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 TIAM1 NTRK2 RAC1 BDNF CDK5 CDK5R1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB PTK6 LRRK2 EGFR HBEGF HIF1A DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 GCKR GCK NUP35 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 GINS1 GINS2 CDC45 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1 TGFBR2 TGFB1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation BRAF FRS2 CRKL MAPK3 MAP2K1 YWHAB MAP2K2 RAP1A RAPGEF1 NGF MAPK1 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling NRAS PTPN11 FRS2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF2 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly MTTP APOC4 P4HB APOB APOC1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 BTRC ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 CUL1 PSMD12 CCNB1 BUB1B PSMD11 UBB CDC20 FBXO5 PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PLK1 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBB UBA52 UBC RPS27A METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism SCD ERCC2 THRSP PRSS3 PDZD11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MCCC2 SLC5A6 PC BTD PCCA HLCS MCCC1 PCCB ACACB ACACA AKT1 NUP214 PRKCA MAPKAPK2 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNAS B4GAT1 NUP107 NUP188 NUP210 NUP93 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 NMT1 NMT2 NUP62 NDC1 SEC13 NUP133 NUP50 NUP54 NUP42 NUP43 RAE1 RANBP2 NUP35 RAN NUP37 IDUA HEXB NCAN HEXA BGN GLB1L3 GLB1L2 VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB DNM2 PPP2R5D PPP2CA PPP2CB PPP2R1B PIK3R2 PIK3CB PIK3R1 PIK3CA CYP2C9 CYP2C8 CYP2D6 EPHX2 ALOX5 CYP1A2 CYP2E1 CYP3A4 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS4Y2 SDC4 SAR1B SDC2 SDC3 PIK3R4 RPS4Y1 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 PARP16 PARP14 PARP10 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 PARP6 PARP4 PARP9 PARP8 RPS27L RPS15A GPC1 RPS3 GPC3 GPC2 GPC5 RPS2 GPC4 GPC6 FAU AGRN RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TKFC CAV1 HSP90AB1 RPS4X RPS3A PIK3C3 SEC23A SEC24B SEC24A SEC24D SEC24C CALM1 GBA1 GAPDHS GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 UGT1A4 GALE B4GALT1 ST3GAL6 PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT ACSL4 ACSL3 ABCD1 GCKR GCK RAP1A APOB MT-CO1 NDST2 NDST1 SCP2 NDST4 NDST3 CKMT1B HEMK2 GSTK1 PRKAB2 SDS TSTD1 SECISBP2 CACNA2D2 PHKA1 PHKA2 CH25H MTHFD1 SCO1 MTHFD2 SCO2 LARS1 TMEM126A MT-CO2 FAR1 MT-CO3 FAR2 TMEM126B CLOCK SHMT2 SHMT1 CIAO3 CIAO1 SULT1A1 RDH11 AGMO AFMID PIP5K1A PIP5K1B PIP5K1C LTA4H SULT1A4 SULT1A3 SULT1A2 GSTM4 GSTM3 GSTM2 GSTM1 CYP4F2 CYP4F3 CYP4F8 DHFR SULT1B1 PRXL2B SFXN4 ACOT7L GSTM5 LGMN MTMR10 MTMR12 KCNC2 DPYS MTMR14 PRKAG2 MED19 MED15 MED18 SMPD3 SULT1C2 SMPD2 MED11 SMPD4 ATIC SMPD1 TSPO ENOPH1 SULT1C4 CHST6 CHST7 GSTO2 GSTO1 SPHK2 MED26 PGM2L1 MED29 MED28 MED22 SLC7A5 MED25 SDHAF2 CYP21A2 SDHAF3 MED21 SDHAF1 AGPS DPYD CHST1 ACSBG1 SDHAF4 L2HGDH ACSBG2 CHST5 CHST2 RAPGEF3 CHST3 PPARD RAPGEF4 SAMD8 OAT GSTP1 ODC1 DLST ABCB11 RIDA SULT1E1 KCNB1 BBOX1 GID4 GID8 CIAPIN1 CRAT KCNG2 ALDH1L1 SLC27A1 ALDH1L2 NUDT11 FADS2 NUDT10 UROD NUDT19 NEK1 NUDT16 NUDT15 FADS1 NUDT13 NUDT12 UGT2B10 UGT2B11 UGT2B15 UGT2B17 TPST2 TPST1 ACLY SMS SLC27A3 SLC27A2 SLC27A5 UQCRB GMPS GSTT2 GMPR GSTT1 NRF1 CYP2C19 CYP2C18 NPAS2 UQCRH NDOR1 AMDHD1 PGK1 PGK2 KDSR IP6K1 IP6K3 NADK IP6K2 AGXT2 UROS BMX G6PC1 UCKL1 G6PC2 G6PC3 SP1 UQCRQ OGN TBXAS1 ACO1 ADSS1 HPSE ACO2 ADSS2 OSBPL1A MT-CYB SNAP25 ALAS2 ALAS1 PTEN APIP ETFA ETFB ALAD SPR PGM2 ACP5 UGT2A3 UGT2A2 PGLS UGT2A1 PGM1 CERS3 CERS4 CERS5 CERS6 RRM2B UGT2B4 AGXT BCAT1 GAPDH DCTPP1 FXN SMIM20 TNFRSF21 CERS1 UGT2B7 CERS2 BCAT2 PRPS2 PRPS1 PRKAA2 CARNMT1 UGT2B28 FOXRED1 SRM SRR PHKG1 AWAT1 PHKG2 TSPOAP1 SLC36A4 MID1IP1 CYP4B1 GSTZ1 SUCLA2 UROC1 NAGS DMGDH SLC23A2 CERK ECI1 SLC23A1 NUDT5 NUDT3 NUDT4 STS HYKK PPAT MFSD2B OMD TALDO1 BCS1L CYP39A1 PYURF PPA2 PPA1 TRIB3 CES3 CES2 CES1 SLC45A2 NEU2 NEU3 BRIP1 APOM NEU1 B4GALNT1 APOE DECR2 PCK1 B4GALNT2 DECR1 PCK2 DMAC2L SLC10A1 SLC10A2 MED13L EXT1 AIMP1 CYP26A1 EXT2 BST1 AIMP2 NDUFAF8 ALDH6A1 NDUFAF6 EPRS1 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 KYAT3 NDUFAF3 KYAT1 NDUFAF1 LDHAL6A LDHAL6B COX7B ACY3 ACY1 HIBADH CROT COX7C KHK MT-ATP6 THTPA NMRK2 NMRK1 PHGDH COX8A SREBF1 COX8C GAA SREBF2 APRT EEF1E1 AHCY HSD17B3 HSD17B4 FITM1 FITM2 HSD17B7 COX5B HSD17B8 COX5A GNAI1 GNAI2 CYP17A1 ORMDL2 HSD17B1 ORMDL3 HSD17B2 XDH PNPLA7 ORMDL1 GCG COX6C CYP8B1 MT-ATP8 NUDT7 KCNS3 NDUFAB1 PNPLA4 PNPLA5 PNPLA6 GDA TACO1 INPPL1 MSMO1 COX6A1 COX6A2 TXN2 AKR7A2 AKR7A3 PPIP5K1 PPIP5K2 ENPP6 ENPP7 TPTE2 ACOT11 ACOT12 ACOT13 SDHC SDHD SDHA COX6B2 KMO SDHB COX6B1 SHPK SULT6B1 COX19 UBIAD1 NNMT NDUFB10 COX16 COX15 NDUFB11 COX18 COX17 CACNA1A CACNA1D CACNA1C GLYAT HIGD1A CACNA1E HIGD1C AANAT DHRS7B COX11 COX14 COX10 SYT5 EEFSEC PDHA2 PDHA1 HIGD2A NAT1 NAT2 DEGS1 DEGS2 GALK1 COX20 TNFAIP8 PODXL2 TAT CYP4A22 ACOXL CYP26B1 TMEM223 CA1 CA3 CA2 CA4 CA7 CA6 CA9 CAD CYP4A11 CYP26C1 ACOX2 ACOX3 NAT8L FBP1 FBP2 GALT NAXE SLC3A2 NT5C2 PPOX GK3 GK2 OXCT1 CBS POLD1 TGS1 OXCT2 PRPS1L1 CRYM HSD3B7 RRM1 RRM2 FAHD1 HSD3B2 HSD3B1 HS3ST5 HS3ST6 SUOX HS3ST4 TTC19 HS3ST1 HS3ST2 GALNS GALC CARM1 SARDH GALM NAXD GLA CDA PI4K2B XYLT2 XYLT1 GLS NAMPT GAMT ARMC8 MTAP PRKD3 HMBS PRKD2 PRKD1 ADPRM PI4K2A TPH2 TPH1 ADH7 SDSL GNS ADH5 ADH6 ACMSD LDHC ADH4 LDHB LDHA TTPA HMOX1 ST3GAL5 CGA HMOX2 FDFT1 LHPP NR1D1 MCAT SQLE TCN2 TCN1 ADI1 PAH PPT1 MMS19 PPT2 ITPA GPI PYGB MOCS2 MOCS3 PYGM GPT PYGL CSAD MCEE TK2 TK1 RAB5IF TPI1 COQ10B COQ10A GCHFR MTF1 AHRR PLIN3 TKT GART WDR26 SGMS1 SGMS2 PAPSS2 PAPSS1 SLC17A5 CKB LDLR CKM RNLS TPK1 GSS GLYCTK MOCOS SQOR NR1H4 NR1H3 G0S2 AGMAT GNMT MKLN1 GATM COQ8B COQ8A VKORC1L1 TPMT RPL10L RPL10A TM7SF2 PPP1CC MPC1 MPC2 SLC26A11 CSGALNACT1 RARS1 CSGALNACT2 IPMK DIO1 DIO2 DIO3 KERA PGD CSNK1G2 IPPK SLC26A2 SLC26A1 INSIG2 INSIG1 HMMR MTM1 TPO MPC1L OSBPL9 COA3 OSBPL7 RAB4A OSBPL6 COA1 OSBPL3 OSBPL2 M6PR PHKB SYNJ2 SYNJ1 PUDP RAB5A GAL3ST1 ADPGK AMD1 PIK3C2G PIK3C2A FTCD PIK3C2B IDH3B PRKG2 HMGCS2 LBR IDH3A COA5 ADSL UGT1A1 GGPS1 HMGCS1 CHPF2 APOA2 FAAH2 APOA1 RPL13A APOA4 BPGM APOA5 TST ALDH9A1 RPEL1 TPTE PDHB BPHL CYP3A5 CYP3A7 TTR UGT1A5 UGT1A3 BCO2 UGT1A9 BCO1 ALOXE3 UGT1A8 UGT1A7 UGT1A6 IDH3G CYP51A1 APOC3 BCKDK RAB14 VAPA VAPB PSAT1 CTH APOC2 SLC35B3 SLC35B2 ISCA2 ISCA1 MTRR GBA3 HS6ST1 GBA2 HS6ST2 HS6ST3 PNP RPL18A RPL36AL FLAD1 PDK3 CIAO2B SEPHS2 PDK2 PDK1 PDHX CPT1A SLC51A SLC51B CPT1B TIAM2 POR CYP2U1 MTHFD2L SUCLG2 SUCLG1 SLC22A4 RTEL1 SLC22A5 SLC35D1 STXBP1 SLC35D2 LHB TXN HELZ2 UGCG PYCR1 PYCR2 PYCR3 TYR DERA PM20D1 HAL CYP2S1 CD320 GBE1 SLC22A13 CBR1 BHMT2 CYP7B1 UGDH DTYMK ADH1C ADH1B ADH1A HDC HAAO GDPD1 GDPD3 ZDHHC21 TYMS GDPD5 CYP7A1 PTS TYMP NT5C DUOX1 NT5E PDPR MTHFD1L SPTSSB NT5M SPTSSA CBR4 DUOX2 CBR3 ATP5PF MAPDA ATP5PD NFYA NFYB ATP5PB PTGES2 NFYC PTGES3 GRHL1 PDP1 CYP2W1 GSTA5 PDP2 GSTA4 GSTA3 GSTA2 GSTA1 ATP5PO NDUFA13 NDUFA11 NDUFA12 FOLH1B NDUFA10 COMT CNDP2 CSKMT HADH PHYH HGD NOSIP RPL9P9 COXFA4 PNLIP IDI1 ISYNA1 IDI2 ALOX15 ALOX12 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME MPST CYP2J2 UQCC3 UQCC2 IDH1 UQCC1 IDH2 UQCC6 UQCC5 COQ9 COQ7 COQ6 COQ5 COQ4 COQ3 SEPSECS GRHPR COQ2 AMACR DAO PXMP2 PI4KA CRYL1 PI4KB LRP10 LRP12 GLP1R DBI DBH OPLAH HK2 HS2ST1 HK1 HK3 CYP2R1 DBT CYP3A43 LSS PRODH2 DCK DDAH1 DCT THRAP3 ALDH1A1 RBKS VAC14 PDXK DDC ETFDH DDO UGP2 ALDH1B1 CHSY1 FAM120B PDSS2 CHSY3 PDSS1 LUM NOS3 MT-ND6 MT-ND4 MT-ND5 UXS1 MT-ND2 MT-ND3 MT-ND1 IL4I1 AS3MT NSDHL TDO2 LRAT XYLB STARD3 STARD4 STARD5 STARD6 UPB1 RUFY1 SLC5A8 RBP4 RBP2 ETHE1 RBP1 UQCRC1 UQCRC2 IDO2 HPD IDO1 MTMR1 HACD1 MTMR2 HS3ST3A1 MTMR3 RETSAT ABCB7 ABCB4 MTMR8 MTMR9 IQGAP1 HACD3 MTMR4 HACD2 OAZ1 MTMR6 OAZ2 HACD4 MTMR7 SLC5A5 OAZ3 HSD11B1 UGT8 HSD11B2 CYB5R3 CYP2B6 HAO1 HAO2 GPIHBP1 ABCA1 B3GALNT1 GLYATL3 GLYATL2 GLYATL1 CS BHMT UCK2 UCK1 NOSTRIN ARF3 ARF1 RPLP1 RPLP0 QPRT ECSIT AACS TRMT112 B3GALT2 B3GALT1 RPLP2 ELOVL1 ARG2 LYPLA1 ELOVL4 ELOVL2 PGAM1 PGAM2 ELOVL3 SIRT4 SIRT5 ELOVL6 ELOVL7 PTGR1 PTGR2 SUMF2 SUMF1 SIRT3 BDH2 BDH1 DLD VAMP2 FH DMAC1 DMAC2 KARS1 UCP1 PTGS2 PET117 PTGS1 EXTL2 HAS1 UCP3 UCP2 CARNS1 HAS3 HAS2 CYP2F1 GC EXTL3 GK PET100 MDH1 MDH2 AADAT FABP9 FABP1 LETM1 FABP2 FABP3 LYRM2 AADAC FABP5 LYRM4 FABP6 FABP7 LYRM7 RPL22L1 GGT3P UGT1A10 PECR HNMT SAT1 STK11 HPGDS OSBP SLC25A44 EPM2A AKR1E2 PIPOX SLC25A51 KPNB1 PFKFB2 PFKFB1 PFKFB4 PFKFB3 CYP19A1 ACAT2 SLC9A1 ACAT1 SLCO1B1 DSEL PMVK SLCO1B3 THEM5 THEM4 HACL1 GOT1 SRD5A2 SRD5A1 GOT2 SRD5A3 B3GALT4 B3GALT6 B3GALT5 GGCT MLXIPL SLCO1A2 UST SLC25A2 COX4I1 COX4I2 FHL2 PIK3CD PIK3CG NADK2 DSE ME1 ME3 UPP2 ME2 UPP1 NDUFC2 ARNT NDUFC1 CYP2A7 SLC25A15 CYP2A6 SLC25A18 SLC25A17 SLC25A19 SLC25A10 SLC25A12 SLC25A4 SLC25A11 SLC25A14 ST6GALNAC5 SLC25A13 ST6GALNAC6 NDUFB9 NDUFB8 NDUFB7 LRP1 NDUFB6 PPM1L NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HSD17B14 HSD17B13 LRP2 PPM1K HSD17B12 HSD17B11 LRP8 HSD17B10 SLC25A27 CKMT2 SLC25A28 D2HGDH PCBD1 SLC25A21 SLC25A20 IARS1 SLC25A22 CYB5B NDUFA9 NDUFA8 CYB5A NDUFA7 NDUFA6 MMAA MMAB NDUFA3 NDUFA2 NDUFA1 AKR7L RPL23A DHODH SLC25A37 TMLHE NT5C1A NT5C1B SLC25A32 DHFR2 AHCYL1 TXNDC11 NUBP1 NUBP2 ACAD11 ACAD10 ARSA ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 ASRGL1 PPP1R3C STX1A MMADHC GCDH PIK3R3 PIK3R6 PIK3R5 ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSF ARSG ARSD RIMKLA HMGCLL1 RIMKLB CTSA SURF1 ADHFE1 PAICS ACER2 ACER1 TH RPL27A ACER3 RGL1 MOGAT3 MOGAT2 MOGAT1 TECR AKR1B1 HSCB WASL ARV1 SPTLC1 ACADL SPTLC2 SPTLC3 HYAL2 MLX CD38 ACADM ACADS AASS VKORC1 ACAD8 STARD3NL ACAD9 AKR1A1 INPP1 AKR1D1 RXRB CYP2A13 GCH1 PLEKHA1 PLEKHA2 NUBPL AKR1C1 GCGR PLEKHA5 AKR1C3 AKR1C2 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 PLEKHA8 PPP1CA KGD4 ALDH4A1 ACAA2 CPOX CYP46A1 DUOXA1 DUOXA2 GGT1 ACAA1 SBF1 SBF2 G6PD MAT1A DPEP2 DPEP1 ATP5MC2 ATP5MC3 FUT2 FUT1 FUT4 ATP5MC1 FUT3 FUT6 FUT5 EBP FUT7 CYP11A1 FUT9 CYC1 NDUFV3 NDUFV2 PRODH NDUFV1 GGT5 FDPS GGT7 GGT6 SLC52A2 SLC52A3 SLC52A1 QDPR GCLC CYP11B2 CYP11B1 CYCS GCLM CHD9 ACSM2A MTR DNPH1 ACSM2B GPHN CPT2 UQCRFS1 A4GALT SULT4A1 HS3ST3B1 BCKDHA GLRX5 BCKDHB ABHD14B DARS1 LMBRD1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 CHDH NDUFS4 NDUFS3 BLVRB NDUFS2 MVD NDUFS1 BLVRA PAOX MVK MAT2B SAMHD1 CYGB INS HMGCL MAT2A MBTPS1 UQCRHL RPIA CYP24A1 MBTPS2 RPL26L1 PNMT RPL4 RPL5 RPL30 RPL3 RPL32 GLDC RPL31 RPL34 ENO1 ENO2 RPL8 ENO3 ENO4 RPL6 RPL7 GCSH FDXR RPL36 PIP4K2A PLCE1 RPL35 CYP1B1 PIP4K2B RPL38 PIP4K2C MMUT RPL37 RPL39 SULT2A1 ACOT9 CUBN ACOT8 MECR ACOT7 RPL21 GLCE RPL23 RPL22 MED8 MED9 HOGA1 CLPS FDX1 FDX2 ACOT2 ACOT1 RPL24 NHLRC1 RPL27 HPRT1 RPL26 RPL29 RPL28 ACOT4 ABO CHST11 CHST12 CHST15 PLCG2 SLC19A3 PNPO CHST13 CHST14 SLC19A1 SLC19A2 CDK19 RPL41 MTHFR MTHFS RPL3L FA2H GLUD1 GLUD2 SLC6A7 SLC6A8 OGDH CYP1A1 PLCH1 PLCH2 ADA ADK ADO SERPINA6 PFAS TMEM186 PIP4P1 IMPA1 IMPA2 RFK LDLRAP1 MIOX ITPK1 TIMM21 BAAT ITPKB TMEM177 ITPKC PLCB3 PLCB4 IVD ITPKA PLCB1 PLCB2 OCA2 ASAH1 ASAH2 RPL10 RPL12 RPL11 RHD RPL14 SC5D RPL13 RPL15 RPL18 RPL17 RPL19 AOC3 AOC1 AOC2 TIMMDC1 AGL FMO1 FMO2 NMNAT3 FMO3 NMNAT2 AGT FIG4 NMNAT1 FMOD PLCD3 PLCD4 PLCD1 CHRM3 CHPF AHR FABP12 ABHD10 MAEA NAGLU IYD CHP1 GYG2 GYG1 AIP CACNB2 CACNB3 RHCE CEMIP FECH GLO1 AK1 ASMT AK2 ITPR1 ITPR2 MRI1 AK4 ITPR3 AK5 ABHD5 AK6 CYP4F22 AK7 AK8 AK9 ESD PSAP UGT3A2 UGT3A1 ESRRA SLC37A1 ASNS DHCR24 TECRL CYP4F11 CYP4F12 ALB SERINC1 DHCR7 SERINC3 SERINC2 SERINC5 SERINC4 GADL1 RPL7A GM2A SLC37A4 AMN GPX2 GPX1 GPX4 SORD AMT ADRA2C ADRA2A INMT SARS1 RPL37A ASPG ASPA ACSS2 GLS2 RPE TYRP1 RPL36A GLRX ACSS1 KCNJ11 TXNRD1 RPL35A PTPN13 ASS1 MARCKS PFKL IMPDH1 IMPDH2 FOLR2 CDO1 PFKM MMACHC PFKP SLC46A1 FAAH ACSM3 HPSE2 ACSM1 GDE1 ACSM6 ACSM5 ACSM4 NADSYN1 CHAC2 CHAC1 PTGDS GLUL SACM1L CMC1 ACSL6 ACSL5 SLC6A12 SLC6A11 CMBL CYP27A1 INPP4A INPP4B PLPP6 COX7A2L VDAC1 PLPP3 PLPP2 ALDH7A1 PLPP1 PTGES MTARC2 MAOB MTARC1 MAOA MGST3 MGST1 MGST2 INPP5B CYP27B1 DGUOK SGPL1 INPP5A INPP5F INPP5D INPP5E INPP5J INPP5K NAALAD2 SCAP ASL HTD2 GSTT2B RPL39L TRAP1 CBLIF CIDEA ACADSB ALOX15B AKR1B10 STAR AKR1B15 HILPDA STAB2 HCCS GYS2 GYS1 GLIPR1 AUH QARS1 GUK1 NNT ANKRD1 TNFAIP8L1 TNFAIP8L3 FFAR1 TNFAIP8L2 DLAT MANBA NME2 NME3 AMPD1 NME4 AMPD2 AMPD3 NME1 B3GNT7 NME6 B3GNT5 B3GNT4 FAM20B B3GNT3 B3GNT2 ALDOC ALDOB ALDOA UMPS SPAM1 UQCR11 ALOX12B UQCR10 AKAP5 ATP5F1A ATP5F1B CA12 NQO1 OLAH ARNT2 NQO2 SCD5 RANBP9 ATP5F1C FAH LYVE1 ATP5F1D ATP5F1E BMAL1 PSPH CA14 CA13 SPNS2 OCRL DCTD ALDH3A1 OXA1L FOLH1 CMPK1 ABCG2 COX7A2 ADIPOR1 ADIPOR2 COX7A1 ALDH3B2 ALDH3B1 ACBD7 HSPA9 ACBD6 ACBD5 ACBD4 EPHX1 AZIN2 ACSF3 NMRAL1 ACSF2 AZIN1 MAN2B2 MAN2B1 ABCD4 B4GALT2 B4GALT3 ACADVL ABCD3 SLC2A1 SLC2A2 SLC2A3 SGSH DHTKD1 ALDH2 PLCZ1 CA5B CA5A CYP4V2 NAPRT KYNU AOX1 MAN2C1 HIBCH TSHB PSTK ABCC3 ABCC1 ABCC2 PTGIS ABCC8 ABCC5 DCXR MARS1 CTPS2 CTPS1 HPDL EHHADH HKDC1 PXYLP1 LALBA B4GALT6 B4GALT7 B4GALT4 B4GALT5 PON3 HPGD GMPR2 PON2 PON1 PRELP LTC4S RMND5B RMND5A BPNT2 BPNT1 B3GAT3 B3GAT2 B3GAT1 SGPP2 SGPP1 POMC PIKFYVE GNPDA1 GNPDA2 ALOX5AP SCLY PIAS4 UBE2I VDR NR1H2 RORA RXRA SUMO2 PPARG PPARA MINPP1 ECHS1 CPS1 ARG1 TP53 OTC LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A MIGA2 DGAT2 PCYT2 CSNK2A1 DGAT1 MIGA1 STARD7 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 CSNK2B GPD1 PLA2G10 PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLA2G6 PLD1 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB CHKA OSBPL5 STARD10 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP OSBPL10 ACP6 PLA2G4F PLA2G12A PCYT1B PCYT1A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLAAT1 PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PLA2G1B AGPAT1 AGPAT2 AGPAT3 SELENOI AGPAT4 AWAT2 GPAT4 GPAT3 GPAT2 CEPT1 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A DDHD2 MBOAT1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 PLCG1 PPP1CB PPP2R1A PRKACA HSP90AA1 UBA52 UBB PRKAR2B UBC RPS27A PRSS1 PHYKPL CTRB2 CTRB1 HSPG2 BCAN CTSL DCN CD44 ACAN CCNC LIPE PDK4 MED1 ACSL1 MED4 MED6 MED7 PEX11A PPARGC1A PPARGC1B CREBBP CIDEC MED16 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 ELOVL5 NCOA6 NCOA3 MED27 MED23 NCOR2 MED24 NCOR1 MED20 PLIN2 ANGPTL4 PLIN1 GPS2 TBL1X FABP4 EP300 ADIPOQ TBL1XR1 LPL MED30 MED31 MORC2 CDK8 SIN3A ACSS3 HDAC3 SMARCD3 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds GSS OPLAH SULT1A1 TPMT SULT1A4 SULT1A3 SULT1A2 GSTM4 GSTM3 GSTM2 GSTM1 UGP2 SULT1B1 GSTM5 AHCY UXS1 CYP1A2 AS3MT SULT1C2 SULT1C4 GSTO2 GSTO1 UGT1A1 GSTP1 UGT1A5 SULT6B1 UGT1A3 SULT1E1 UGT1A9 ABHD10 NNMT GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 UGT1A6 AKR1A1 GLYAT TRMT112 MTRR UGT2B10 UGT2B11 UGT2B15 UGT2B17 TPST2 NAT1 TPST1 NAT2 BPNT2 BPNT1 ESD UGT3A2 PODXL2 UGT3A1 GSTT2 GGT1 GSTT1 MAT1A SLC35D1 SLC35D2 GGT5 GGT7 GGT6 UGT1A4 GCLC UGDH GCLM ACSM2A MTR ACSM2B GGT3P UGT1A10 UGT2A3 UGT2A2 UGT2A1 SULT4A1 HPGDS ABHD14B ACSM1 UGT2B4 ACSM5 ACSM4 CHAC2 CHAC1 UGT2B7 UGT2B28 MAT2B GSTA5 GSTA4 MAT2A GSTA3 GSTA2 GSTA1 GGCT GSTZ1 COMT CNDP2 MGST3 MGST1 MGST2 GSTT2B SULT2A1 HEMK2 GSTK1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes BCL2 NLRP3 NFKB1 BCL2L1 APP NLRC4 MEFV NFKB2 PANX1 P2RX7 PYCARD PSTPIP1 AIM2 CASP1 HMOX1 TXNIP HSP90AB1 NLRP1 TXN SUGT1 RELA THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model SLC25A14 UCP3 UCP2 SLC25A27 UCP1 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SKP2 RB1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation AIMP1 LARS1 AIMP2 MARS1 EEF1E1 EPRS1 PPA1 KARS1 IARS1 AARS1 HARS1 YARS1 DARS1 WARS1 RARS1 GARS1 QARS1 NARS1 SARS1 CARS1 FARSA TARS1 VARS1 FARSB MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 RAP1B HGF CRKL DOCK7 GAB1 MET CRK RAC1 RAP1A RAPGEF1 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes EP300 BCL2 NOTCH1 EGF PDGFA MAFK BCL2L1 AREG SP1 NFE2L2 CREBBP ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) SREBF1 DHCR24 SREBF2 TM7SF2 CYP51A1 MSMO1 HSD17B7 NSDHL CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA PTPN6 BTLA TNFRSF14 PTPN11 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L RPL37A RPL23A RPL36A RPL35A EEF1B2 EEF1G RPL22L1 EEF1A1 EEF1D EEF1A2 EEF1A1P5 EEF2 RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A RPL37 RPL39 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation FGFBP1 FGF7 FGF1 FGFBP2 FGFBP3 FGF22 FGF3 FGF10 FGF2 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border ZIC1 MYB MSX1 TFAP2A TFAP2B CTNNB1 TFAP2C FGF4 BMP4 TCF7L1 WNT3A DLX5 PAX3 POU5F1 SOX2 PAX7 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) AKT1 TSC2 TSC1 AKT2 AKT3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism AIMP1 RPL24 AIMP2 RPL27 ALDH6A1 DBH RPL26 RPL29 EPRS1 RPL28 KYAT3 DBT KYAT1 PRODH2 DCT HIBADH RPL41 DDC RPL3L DDO GLUD1 GLUD2 SLC6A7 PHGDH SLC6A8 OGDH EEF1E1 ADO AHCY IL4I1 TDO2 IVD ETHE1 OCA2 IDO2 RPL10 HPD RPL12 IDO1 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 TXN2 AOC1 FMO1 OAZ1 OAZ2 RPS15 RPS14 SLC5A5 RPS17 UBA52 OAZ3 RPS16 KMO RPS19 RPS18 HAO1 NNMT RPS11 IYD RPS10 PSMD12 RPS13 PSMD11 BHMT RPS12 PSMD14 PSMD13 GLYAT RPLP1 PSMA7 RPLP0 PSMB6 RPS27A AANAT PSMD8 ASMT PSMB7 PSMB4 PSMD6 MRI1 RPS4Y2 RPLP2 PSMB5 EEFSEC PSMD7 ARG2 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RPS4Y1 SIRT5 ADRM1 TAT PSMA5 SEM1 PSMA6 ASNS PSMA3 PSMC5 PSMA4 PSMC6 DLD PSMC3 SERINC1 PSMA1 RPS26 PSMA2 SERINC3 RPS25 PSMC4 SERINC2 RPS28 KARS1 PSMC1 SERINC5 RPS27 PSMC2 SERINC4 RPS29 GADL1 MCCC2 RPL7A RPS20 NAT8L RPS21 RPS24 RPS23 MCCC1 CARNS1 SLC3A2 AMT PHYKPL INMT SARS1 CBS RPL37A ASPG ASPA AADAT GLS2 CRYM TYRP1 RPL36A TXNRD1 RPL35A SUOX ASS1 RPL22L1 HNMT CDO1 SAT1 SARDH SLC25A44 PIPOX GLS GAMT RPS27L MTAP RPS15A GLUL RPS3 ACAT1 TPH2 TPH1 SLC6A12 SLC6A11 SDSL RPS2 GOT1 ACMSD GOT2 ALDH7A1 CGA FAU SLC25A2 ADI1 RPS9 PAH RPS7 RPS8 RPS5 RPS6 NAALAD2 RPSA ASL GPT SLC25A15 CSAD RPL39L SLC25A10 SLC25A12 ACADSB CKMT1B SLC25A13 SDS TSTD1 SECISBP2 AUH QARS1 PAPSS2 PAPSS1 CKB CKM LARS1 PPM1K SQOR CAV1 HSD17B10 CKMT2 SHMT1 AGMAT GNMT PCBD1 GATM SLC25A21 IARS1 AFMID RPL10L RPL10A RPS4X RARS1 RPS3A DIO1 RPL23A DIO2 NQO1 DIO3 TMLHE TXNDC11 FAH TPO PSPH FOLH1 ASRGL1 ENOPH1 GCDH AMD1 FTCD AZIN2 SLC7A5 NMRAL1 RIMKLA AZIN1 RIMKLB TH RPL27A RPL13A DHTKD1 TST ALDH9A1 OAT KYNU ODC1 DLST HIBCH RIDA TSHB PSTK BBOX1 AASS CRAT ACAD8 MARS1 BCKDK PSAT1 CTH MTRR RPL18A RPL36AL SMS KGD4 ALDH4A1 SEPHS2 DUOXA1 DUOXA2 SCLY MAT1A AMDHD1 SLC22A4 AGXT2 PYCR1 PYCR2 PYCR3 TYR PRODH HAL ECHS1 CPS1 ARG1 TP53 BHMT2 OTC QDPR APIP HDC HAAO MTR DUOX1 BCKDHA BCKDHB DARS1 AGXT BCAT1 DUOX2 CHDH BCAT2 PAOX CARNMT1 SRM SRR SLC36A4 GSTZ1 RPL26L1 PNMT FOLH1B RPL4 UROC1 RPL5 NAGS DMGDH RPL30 RPL3 RPL32 GLDC RPL31 HGD RPL34 RPL9P9 RPL8 HYKK RPL6 SLC44A1 RPL7 SLC44A2 GCSH RPL36 RPL35 MPST RPL38 SLC45A2 RPL37 RPL39 RPL21 RPL23 SEPSECS RPL22 GRHPR HOGA1 DAO PXMP2 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 STAT3 NTRK1 NGF BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives ALOX5 PTGS2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production CAPZB KIF13B HMG20B IFNA21 KIF1C KIF1B KIF1A JAK2 KIF25 KIF23 KIF22 KIF6 RBSN KIF27 RAD51B KIF9 RAD51C KIFC2 KIF2A KIFC1 IRF1 IRF2 KIF2C KIF2B DOCK2 AKAP1 CDC42 MFN1 MFN2 SH2B3 SH2B2 SH2B1 CABLES1 CABLES2 CENPE WEE1 KIF26A CAPZA1 KIF26B CAPZA2 ITPK1 VPS45 PRKACA RAB5A H3-3B H3C8 H3C15 PRKAR2B IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 ABL1 TP53 DOCK7 CBX5 MAFK CDK5 SIN3A MYB KIF28P KDM1A PRKACG JMJD1C DOCK10 PRKACB RAC1 DOCK11 KIF5C KIF5B KIF5A KIF21A IFNB1 KIF21B KIFAP3 HBE1 PRKAR1B KIF16B KIF20A PRKAR1A KIF20B ZFPM2 ZFPM1 GATA6 DOCK1 GATA5 AK3 GATA4 KLC1 GATA3 GATA2 GATA1 IFNA14 PHF21A KLC4 KLC3 IFNA16 KLC2 KIF3A KIF3B RACGAP1 PRKAR2A HDAC2 IFNA17 MICAL1 KIF3C NFE2 CARMIL1 CDK2 HBG2 HDAC1 HBG1 EHD1 EHD2 KIF18A EHD3 KIF18B KIF4B KIF4A MAFG MAFF RCOR1 DOCK6 DOCK5 IFNA10 DOCK4 DOCK3 DOCK9 DOCK8 HBB KIF12 KIF11 HBD KIF15 AKAP10 KIF19 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion SI LCT PNLIPRP1 GUCY2C PNLIPRP2 MGAM CHIA AMY2A AMY1A AMY2B TREH AMY1B AMY1C GUCA2B CEL GUCA2A LIPF CHIT1 PIR PNLIPRP3 ALPI CLPS PNLIP RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2S1 EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF2B2 EIF2B1 EIF2S2 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation NOS2 CORO1A HGS UBB ATP6V1H VPS33B RAB7A UBC RPS27A KPNA1 UBA52 RAB5A KPNB1 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling CA1 RALA JAK2 TCP1 PITPNA BOLA2B LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B GSTA2 IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF SOD2 CDC42 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 PPIA RAP1B SNRPA1 JAK1 LCP1 P4HB TALDO1 CAPZA1 AIP ARF1 TYK2 RPLP0 GSTO1 HSPA9 MTAP REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity CUL1 FBXL17 BACH1 UBB SKP2 MAFK UBA52 UBC SKP1 RPS27A RBX1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC7A6 SLC7A7 SLC7A5 SLC7A8 SLC7A9 SLC6A12 SLC36A4 SLC3A2 SLC43A2 SLC43A1 SLC1A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC38A1 SLC6A19 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes H2AC14 AGPAT2 H2BC12L KANSL1 SCD KANSL2 PDK4 KANSL3 KAT8 THRSP MED1 ACSL1 MED4 HCFC2 MED6 MED7 HCFC1 WDR82 PAXIP1 PEX11A GPAM PPARGC1A PPARGC1B KAT14 CREBBP H4C9 LPIN1 SETD1B PNPLA2 SETD1A CIDEC TADA2A ZZZ3 H2AC20 H2AX PHF20 ASH2L SGF29 MED16 MED17 MED12 MED14 MED13 MED10 CD36 H3-3B NCOA1 NCOA2 H3C8 ELOVL5 NCOA6 NCOA3 MED27 SIRT1 MED23 NCOR2 PHF20L1 KAT2B KAT2A H2AJ MED24 AJUBA NR5A2 NCOR1 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H3C15 TBL1X H2BC9 H2BC8 H2BC5 MCRS1 H2BC3 H2BC1 FABP4 H2AB1 EP300 PHLDA1 MEN1 H2AC8 H2AC6 H2AC7 ADIPOQ TBL1XR1 KMT2D KMT2A KMT2C KMT2B RXRA BOD1L1 LPL MED30 MED31 MBIP ABL1 TASP1 DR1 BOD1 CDK8 CDK5 YEATS2 TADA3 DGAT2 OGT AKAP8L PSIP1 DPY30 PAGR1 H2BC26 H2BC21 WDR5 KDM6A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CEBPA ACSS3 HDAC3 CXXC1 RBBP5 RB1 H2AC19 CCNC MGLL H2AZ2 LIPE METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors RNLS LRP2 TPK1 BST1 MOCOS SHMT2 SHMT1 SLC19A3 PNPO CYB5A SLC19A1 SLC19A2 MMAA MMAB MTHFR PDXK MTHFS THTPA PRSS3 NMRK2 NMRK1 DHFR SLC25A32 DHFR2 RFK LDLRAP1 MMADHC SLC5A8 GSTO2 GSTO1 PDZD11 ABCD4 SLC2A1 SLC2A3 NMNAT3 NMNAT2 NMNAT1 NAPRT AOX1 CYB5R3 NNMT CD38 ABCC1 ALDH1L1 ALDH1L2 QPRT MTRR NUDT12 FLAD1 PARP16 PRSS1 PARP14 MTHFD2L PARP10 MCCC2 NADK SLC5A6 PC BTD AMN PCCA HLCS NAXE MCCC1 PCCB ACACB ACACA CTRB2 CTRB1 CD320 SLC52A2 SLC22A13 SLC52A3 SLC52A1 PARP6 PARP4 MTR ACP5 GPHN PARP9 FOLR2 MMACHC PARP8 NAXD SLC46A1 NT5E MTHFD1L SLC25A51 LMBRD1 NAMPT NADSYN1 SLC23A2 TCN2 SLC23A1 TCN1 NADK2 MOCS2 MOCS3 PANK4 PANK2 SLC25A19 PANK3 CBLIF PANK1 MMUT DCAKD COASY PPCDC SLC25A16 NUDT8 CUBN VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT MTHFD1 MTHFD2 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2R1B MAPK7 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MAPK1 PPP2R1A MAPK3 PPP2R5D PPP2CA PPP2CB CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response ADAM17 IL10 FURIN IL6 CD163 PLK2 RHBDF2 MAPK14 MYH9 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 ERCC3 ERCC2 PRDM1 COX7B TNRC6C MOV10 AGO3 AGO4 AGO1 COX7C AGO2 TNRC6A TNRC6B COX8A COX8C YWHAE PIP4P1 COX5B COX5A PPP2R1A COX6C YWHAG CDKN2A COX6A1 COX6A2 TNFRSF10B TNFRSF10A FAS UBA52 COX6B2 COX6B1 CPAP AKT2 AKT3 AURKA CCNB1 UBB UBC HIGD1C RPS27A CDK1 SFN PMAIP1 BID BBC3 PLK2 MDC1 ATF2 TP53RK NOC2L TP53AIP1 KAT5 CHEK2 GPX2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB YWHAB DDIT4 RRAGD DNA2 RHNO1 L3MBTL1 GLS2 AKT1 MEAF6 MAPKAP1 PRDX2 NUAK1 PCBP4 PRMT1 PRDX1 TP53BP2 YWHAZ TXNRD1 ATRIP PRELID3A BANP BARD1 PLK3 PRELID1 CRADD GADD45A TPX2 CARM1 RAD17 ATM STK11 CDK12 CDK13 ATR TP73 CDKN1A BTG2 GLS SETD9 PRKAG1 CDK5R1 CHM MAPK14 BRCA1 MAPK11 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 RMI2 BRD1 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D COX7A2L SGK1 PCNA WRN PLAGL1 PERP PMS2 RICTOR BRD7 TIGAR NPM1 RPA1 COX4I1 RPA2 COX4I2 MLH1 HIPK1 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 GPI LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 CCNA2 MRE11 CCNA1 SESN3 SESN2 MT-CO1 NBN KMT5A BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 PRKAB2 KAT6A MAPKAPK5 BLM NDRG1 CCNH SMYD2 EHMT2 SLC38A9 BCL2L14 EHMT1 MAP2K6 ZNF420 FANCI BRPF1 SCO2 BRPF3 TNFRSF10C FANCC MT-CO2 CNOT10 TNFRSF10D MT-CO3 CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 RHEB CCNK CNOT2 CCNT2 CNOT3 JMY CCNT1 MDM2 PIN1 MDM4 CNOT8 RAD9B CNOT9 YWHAQ SUPT16H RAD9A PRR5 YWHAH PPP1R13B PDPK1 DYRK2 GTF2F1 TRIAP1 GTF2F2 PIDD1 EXO1 CASP6 CREBBP PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 SUPT4H1 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA PRKAG2 RBL2 RBL1 BIRC5 TMEM219 PRKAA1 RNF34 AURKB TP53INP1 RBBP8 E2F4 PHF20 ELOA2 RFFL COX7A2 E2F7 SUPT5H E2F8 CDK9 ARID3A COX7A1 MTOR PML RAD50 TAF4B BAX ELL TAF7L ELOA NELFB ELOB NELFCD NELFA ELOC NELFE CTDP1 CCNE2 TAF9 CCNE1 TAF1L POLR2A POLR2B MBD3 POLR2C POLR2D POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 TAF15 GATAD2B TAF12 GATAD2A TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 TCEA1 TAF6 TAF5 EP300 TAF4 TAF3 TAF2 TAF1 G6PD NLRC4 CASP1 TXN TP53 PTEN CYCS CDK7 CDK5 TFDP1 TFDP2 MNAT1 CSNK2A1 CSNK2A2 RRM2B CHD4 E2F1 CHD3 PPP2R5C CSNK2B JUN PPP2CA PPP2CB PPP2R1B TSC2 TSC1 CDKN1B PRKAA2 TBP COXFA4 HDAC2 CDK2 PIP4K2A HDAC1 PIP4K2B PIP4K2C RBBP4 BRIP1 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2K POLR2L CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism CKMT1B SLC6A12 SLC6A11 CKMT2 GAMT GATM CKB SLC6A7 SLC6A8 CKM TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE TLR3 CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes HMG20B KANSL1 KANSL2 KANSL3 JAK2 CCND1 RELA NFKB1 ATF2 KAT5 MEAF6 PRMT1 CARM1 ING5 PRMT5 BRD1 RPS2 KMT5A KAT6A SMARCB1 SMYD2 EHMT2 H2AC19 EHMT1 ACTB BRPF1 BRPF3 H2AC14 SAP130 KAT8 CLOCK SMARCC1 SMARCC2 HCFC1 KAT14 CREBBP H4C9 SETDB1 SETD1B SETD1A SMARCA2 SMARCA4 TADA2A ZZZ3 H2AC20 EZH2 H2AX PHF20 SUV39H1 ASH2L SGF29 HDAC10 TRRAP H2AC17 H2AC12 EPC1 KAT7 NCOA1 SUPT20H NCOA2 ATXN7L3 H3C8 JMJD6 WDR77 PADI3 PADI2 PADI4 ACTL6A PADI1 PADI6 PRDM16 SETDB2 TADA2B H2AC25 H2AC21 PHF2 NCOR2 SUV39H2 SETD2 KAT2B SETD3 KAT2A SETD6 H2AJ SETD7 PHF8 ING4 NCOR1 ING3 AEBP2 PRMT6 PBRM1 PRMT7 ACTL6B PRMT3 ASH1L TAF9 SUPT3H TAF6L GPS2 DOT1L H3C15 NSD3 TBL1X NSD1 NSD2 BRD8 MBD3 SUZ12 ELP1 H2BC9 ELP2 H2BC8 ELP3 H2BC5 ELP4 MCRS1 ELP5 H2BC3 ELP6 PRDM9 H2BC1 KDM1B JADE1 ARID4A YEATS4 JADE3 JADE2 GATAD2B RUVBL2 TAF12 GATAD2A RUVBL1 KMT5B TAF10 ARID2 KDM2A KDM2B KMT5C ARID5B H2AC1 H2AB1 SUPT7L ARID4B MORF4L1 BRMS1 EP300 KAT6B MORF4L2 HAT1 ENY2 TAF5L ATXN7 H2AC8 EP400 SMYD3 H2AC6 DMAP1 H2AC7 COPRS NFKB2 MRGBP SAP30 RIOX2 TADA1 BRWD1 TBL1XR1 KDM5A KDM5B KDM5C KMT2D KDM5D VPS72 KMT2A UTY KMT2C KDM6B KMT2B MSL2 MSL3 H2BC18 MSL1 KDM7A KDM3A MBIP KDM3B HDAC8 KDM4A KDM4B KDM4C KDM4D SUDS3 USP22 REST DR1 YEATS2 TADA3 OGT DPY30 CHD4 CHD3 PAX3 H2BC26 H2BC21 KDM1A WDR5 KDM6A EED DNMT3A ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PHF21A SMARCD1 HDAC2 SMARCD2 HDAC3 MECOM CDK4 SMARCD3 HDAC1 MTA1 RBBP4 RBBP5 SAP30L RCOR1 SAP18 RBBP7 MTA2 MTA3 ATF7IP SMARCE1 H2AZ2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC7 UBE2C BUB1B UBE2E1 CDC20 UBE2S CDC16 BUB3 ANAPC4 MAD2L1 ANAPC5 ANAPC1 ANAPC2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules PDZD11 SLC35D1 SLC5A6 SLC35D2 LCN9 SLC35B4 ARL2 LCN15 SLC27A1 LCN12 APOD SLC35A2 SLC35A3 SLC33A1 SLC35C1 SLC35A1 ARL2BP LCN1 SLC35B3 SLC29A4 SLC25A4 SLC35B2 SLC27A6 SLC28A2 SLC25A5 SLC29A1 SLC28A1 SLC29A3 SLC27A4 SLC29A2 SLC28A3 SLC25A6 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle WDR6 FLOT2 FAM83B PIK3R2 RASAL2 DSP ANKRD26 DST PIK3R1 TMOD3 CAV1 ARHGAP35 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM PTPN13 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 CKB ARHGAP21 MUC13 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins HPGD LTA4H ALOX5 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor NELFB BAX NTRK3 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A4 SLC9A5 SLC9A1 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A2 SLC9A3 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 CAPZB DBT SRRM1 KIF2A DDX39B KIF2C KIF2B DOCK2 CDC42 MFN1 MFN2 CENPE S100A9 S100A8 MTMR1 HGS RAB7A LMNB1 IQGAP1 CFL1 PAK2 SLC1A5 MYH9 CTNNB1 YWHAB XPO1 LETM1 PRKCD PRKCA YWHAZ TIAM1 MAPK14 MAPK11 RAPGEF1 MAPK1 MAPK3 FRS3 SOS1 LAMTOR1 BUB1B CDC20 STEAP3 BUB3 MAD2L1 CDC25C CUL3 RASAL2 SHMT2 NUP107 PIN1 AAAS NUP160 NUP85 BIRC5 AURKB PIK3R3 SEC13 NUP133 RANGAP1 WASL NUP43 RANBP2 NUP37 AR KDM4C CLTC MTR PPP2R5B DDX4 PPP2R5A ROCK1 PPP2R5D TNFAIP1 PPP2R5C ARHGAP5 PPP2CA PPP2CB RND3 ARHGAP21 MUC13 WDR6 NDUFS3 PPP2R1B FLOT2 FAM83B PPP2R5E DSP CDC37 ANKRD26 ERBIN DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 PLD1 CKAP4 KTN1 NISCH PLD2 VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 ITGB1 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 TRIO JAG1 TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MYLK PREX2 PREX1 WDR91 EPSTI1 ANKFY1 CEP97 FNBP1 PRKCB STARD8 MRTFA BCR DYNC1LI1 DYNC1LI2 PIK3R2 MYL6 DAAM1 WDR81 PIK3R1 MYL9 NGEF CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR FRS2 RHOT2 RHOT1 MYO6 PIK3CA NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARHGAP8 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 YWHAE GMIP DYNLL2 LRRC41 CIT CCP110 CDC42EP5 PPP1CB INCENP CDC42EP4 CDC42EP3 CDC42EP2 PPP2R1A CDC42EP1 VAMP3 PKN3 GPS1 CENPA FGD1 FGD2 CENPC YWHAG FGD3 LMAN1 FGD4 FGD5 CHN2 HSP90AA1 CHN1 FLNA STX5 PPP1R12A YKT6 FARP2 CENPT FARP1 CENPU KIDINS220 USP9X MCF2 WWP2 DEF6 DYNLL1 WDR11 TMEM59 CKAP5 CENPF TAOK3 ABI2 CENPH VMA22 CENPI MAPRE1 GJA1 SHKBP1 TAOK1 ABI1 CENPK PAFAH1B1 CENPL CENPM GOPC DYNC1I2 FILIP1 PKN2 CENPN PKN1 CENPO CENPP CENPQ CENPS PLXND1 NCF1 FAM13B NCF2 FAM13A NCF4 MSI2 STK10 SLK POTEE GOLGA8R TPM4 CLASP1 RALGAPA1 TPM3 SWAP70 DYNC1H1 VRK2 FAM91A1 NDE1 TEX2 PLK1 ARMCX3 CLIP1 OBSCN PHIP MAD1L1 PIK3R4 RHOBTB3 LIN7B RHOBTB1 RHOBTB2 SFN STIP1 DDRGK1 STK38 DVL1 DVL2 PLXNA1 DVL3 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 RPS27 NSFL1C ARPC2 CDH1 ARPC3 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ARHGAP11A ZNF512B ARHGAP11B RASGRF2 SNAP23 BRK1 TAGAP EFHD2 NCK2 SPDL1 NCK1 PLEKHG3 ACTR3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 PTPN13 KLK2 ARFGAP2 LCK DSG2 EVL PPP1R12B SOS2 BLTP3B SRC ROCK2 SRF NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF1 WASF2 WASF3 RNF20 PPP1R14A PCDH7 CDC42BPB CDC42BPA BAIAP2 MYO19 PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 HMOX2 BTK PFN1 CFTR ROPN1 PFN2 GRB7 TMEM87A GARRE1 TWF1 KLK3 KALRN MYL12B SCFD1 DSN1 SCAI SPTBN1 RCC2 STAM PTK2 ZWINT NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 PLIN3 RAC2 RAC3 SPTAN1 GIT1 NDEL1 VCP VAV3 H2AC19 RHOG RHOH RHOF CKB RHOC ACTB RHOD VAV1 H2AC14 VAV2 RHOB H2BC12L ARHGEF9 CTTN RHOJ ARHGEF3 ARHGEF4 CAV1 TAX1BP3 ARHGEF1 RHOU RHOV ARHGEF2 ARHGEF7 DBN1 ARHGEF5 RHOQ ARHGEF6 AMIGO2 HSP90AB1 MIS12 WAS PPP1CC NOXO1 TRAK1 YWHAQ TRAK2 PAK1 YWHAH SAMM50 PDPK1 PGRMC2 PLEKHG4B CTNNA1 EMC3 PAK6 PAK3 DYNC1I1 PIK3C3 H4C9 PAK5 PAK4 BCAP31 IL32 GIT2 MTX1 CAVIN1 MYO9B MYO9A MPP7 DLC1 VHL TRIP10 RAB9A H2AC20 ESYT1 B9D2 OCRL RAB9B SPC24 TJP2 SPC25 H2AX ERCC6L RTKN PRAG1 ZWILCH ARHGDIG ARHGAP39 ACTG1 SYDE2 ARHGAP44 SYDE1 ARHGAP42 ARHGAP40 ACBD5 BASP1 CALM1 ARHGDIA H3-3B ARHGDIB KNTC1 LBR NCOA2 ARHGEF40 H3C8 RALBP1 CYBB CYBA KCTD3 ARHGAP45 ALDH3A2 SGO1 SGO2 STAM2 ABCD3 ARHGEF26 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 PMF1 H2AJ TOR1AIP1 ARHGAP12 ARHGAP22 NCKIPSD ARHGAP20 RHPN1 MYH14 MYH11 RHPN2 ECT2 MYH10 CCNE1 CPSF7 ARHGEF39 H3C15 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 H2BC9 ARHGAP24 H2BC8 ARHGAP23 VAPB H2BC5 ARHGAP33 ARHGAP32 H2BC3 DIAPH1 CCT6A DIAPH2 H2BC1 ARHGAP31 DNMBP ARHGAP30 DIAPH3 DLG4 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 TUBA1B ARHGEF15 H2AB1 ATP6AP1 ARHGEF17 ARHGEF16 CCT2 ARHGEF19 ARAP2 ARHGEF18 ARAP3 MEN1 SENP1 ARHGAP10 TIAM2 H2AC8 ZAP70 GFOD1 H2AC6 ALS2 H2AC7 PEAK1 PDE5A ITGB3BP CCDC187 RAP1GDS1 MOSPD2 FAM169A ADD3 UACA GNA13 TRA2B PTK2B STOM BUB1 CLASP2 SPEN LIMK2 LIMK1 HSPE1 CCT7 SLC4A7 ABL1 FMNL3 FMNL1 ACTC1 FMNL2 VIM DOCK7 H2BC26 H2BC21 CDKN1B KDM1A ARHGAP35 RAC1 DOCK10 DOCK11 KIF5B ARAP1 KIF5A RHOA H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ELMO2 DOCK1 H2BC11 KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 H2AZ2 DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells EP300 MEN1 HDAC4 TBL1XR1 KMT2A HDAC8 CREBBP HDAC11 RUNX3 BMI1 RUNX1 TNF ETS1 YY1 IL4R MAML2 KLF13 MAML1 RING1 SMARCA4 IL13 MAF IRF4 HDAC5 SATB1 HDAC9 RNF2 HDAC6 MAML3 HDAC7 NOTCH2 TBX21 CCL3 STAT6 STAT5A DPY30 ASH2L CBX8 CHD4 STAT5B CHD3 PHC2 CBX6 PHC1 JUN POU2F1 HDAC10 CBX4 CBX2 NFATC2 NFATC1 SNW1 POU2F2 MAMLD1 PHC3 BATF IL4 IL5 WDR5 FOS STAT4 NCOR2 IL12RB2 KAT2B KAT2A NCOR1 IFNG GATA3 HDAC2 TBL1X HDAC3 NOTCH1 MBD3 HDAC1 RBPJ MTA1 RBBP4 RBBP5 GATAD2B GATAD2A TPST2 RBBP7 MTA2 MTA3 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration ACO1 IDH1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine NAGK GFPT2 AMDHD2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling TRADD RNF31 TRAF2 TNFAIP3 XIAP CASP8 OTUD7B SPATA2 SHARPIN RIPK1 USP4 FADD USP21 MIB2 TNFRSF1A TBK1 CYLD OPTN RBCK1 OTUD1 BIRC2 BIRC3 IKBKE TNF USP2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex H2AC14 EP300 H2BC12L MEN1 H2AC8 H2AC6 H2AC7 MYC CTNNB1 KAT5 KMT2B CREBBP H4C9 RUNX3 SMARCA4 H2AC20 H2AX DPY30 ASH2L TCF7L1 H2BC26 TRRAP H2BC21 H3-3B TCF7L2 H3C8 WDR5 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 CDC73 TLE4 TLE3 TLE2 TLE1 AXIN2 H3C15 PYGO1 PYGO2 TCF7 TERT HDAC1 LEO1 LEF1 BCL9L H2BC9 H2BC8 BCL9 H2BC5 H3-4 H2BC3 H2BC1 RBBP5 RUVBL1 H2AC19 H2AB1 H2AZ2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome PSMA5 SEM1 PSMA6 GLI2 PSMA3 PSMC5 SUFU PSMA4 PRKACG PSMC6 PRKACB PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL1 PSMD12 CSNK1A1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 GSK3B PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PRKACA PSMD3 PSMB1 PSMD1 SKP1 ADRM1 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 IKBKE UBB TICAM2 UBC LY96 RPS27A TICAM1 CD14 TLR4 UBA52 TANK TBK1 OPTN TRAF3 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes CSF1 IFNG N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi ST8SIA3 MGAT5 B4GALT2 B4GALT3 MGAT2 FUT3 LHB CGA B4GALT1 ST6GAL1 B4GALT6 B4GALT4 MGAT4C B4GALT5 CHST10 MGAT4A MGAT4B FUT8 MAN2A2 MGAT3 ST8SIA6 CHST8 MAN2A1 ST3GAL4 FUCA1 ST8SIA2 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation ATF1 ELK1 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 MAP3K8 DUSP6 MAP2K3 DUSP7 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 MAPK9 TAB1 ATF2 MAPK8 MAP2K7 MAPK10 TNIP2 CHUK TRAF6 IKBKB IKBKG RIPK2 NOD1 NOD2 MAPKAPK2 PPP2R1A BTRC PPP2R5D MAPK14 SKP1 PPP2CA JUN MAPK11 PPP2CB PPP2R1B MAPK7 FBXW11 NFKB1 FOS MAP2K1 MAPK1 MAPK3 UBA52 MAP3K7 CUL1 UBB UBC RPS27A UBE2V1 MAP2K6 IRAK1 IRAK2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway ERCC3 ERCC2 ZNF610 MEF2C SPI1 ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 ZNF705EP DDIT3 ZNF274 ZNF20 ZNF23 ZNF25 ZNF26 GRIN2A ZNF268 ZNF267 ZNF266 ZNF263 ABCA6 NR2F1 ZNF34 GRIN2B NR0B2 NR2F6 COL1A1 COL1A2 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 HEY1 ZNF41 HEY2 CTLA4 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 ZNF480 ZNF479 ZNF235 ZNF234 ZNF233 ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT BGLAP ZNF227 ZNF468 ZNF226 ZNF225 ZNF223 ZNF222 ZNF221 ZNF461 ZNF460 ATAD2 ZNF77 ZNF79 SKI ZNF70 ZNF71 ZNF74 AGRP PSMD12 ZNF699 PSMD11 ZNF215 NOTCH1 ZNF214 PSMD14 ZNF213 PSMD13 ZNF697 LEF1 RBPJ ZNF696 ZNF212 DLL1 PSMA7 ZNF211 ZNF692 PSMB6 ZNF691 PSMD8 UBE2D3 RORC PSMB7 RORB PSMB4 ZNF208 PSMD6 ZNF205 PSMB5 ZNF689 PSMD7 ZNF688 PSMB2 ZNF446 PSMB3 ZNF445 PSMD2 PITX2 PSMD3 ZNF202 PSMB1 ZNF443 PSMD1 ZNF200 ZNF684 ZNF442 ZNF441 ZNF682 ADRM1 ZNF440 PSMA5 ZNF681 ZFP69B SEM1 PSMA6 FOXP3 PSMA3 NPAS4 SIRT3 PSMC5 ZNF439 PSMA4 ZNF679 PSMC6 ZNF678 ZNF436 PSMC3 ZNF677 PSMA1 ZNF676 PSMA2 ZNF433 PSMC4 ZNF675 PSMC1 ZNF432 PSMC2 PVALB ZNF431 CTNNB1 ZNF430 BLK GRIA2 ZNF671 ZNF670 MAX DLX6 FOXO6 FOXO4 FOXO3 FOXO1 ZNF840P ATXN3 YWHAB MOBP ZKSCAN7 ZNF429 ZKSCAN8 XPO1 ZKSCAN3 AKT1 ZNF668 ZNF426 ZNF667 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 YWHAZ ZKSCAN1 SOCS4 ZNF662 ZNF660 FBXO32 ZNF419 ZNF417 ZNF658 ZNF416 ZNF415 STK11 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 MAPK14 PPM1A MAPK11 HAND2 ZNF875 ITGA5 PPM1D ZNF627 ZNF626 GLI3 ZNF625 GLI2 ZNF624 ZNF621 E2F5 ZNF620 E2F6 ZNF860 MGA TBX5 PINK1 ZNF619 RBX1 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 COX4I1 PTPN4 COX4I2 TRIM33 UXT LGALS3 ZNF729 ZNF727 ZNF726 ZNF724 CCN2 ZNF721 ZFP1 ZFP2 ZNF718 ARNT ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 ITCH ZNF324B L3MBTL2 FOXG1 TGFA ZNF709 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 IQSEC3 ITGBL1 MSTN HNF4G YAP1 SATB2 ZFP14 ZNF585B RXRG ZNF585A GAD1 GAD2 VEGFA CCNG2 ZFP28 PRDM7 IHH CCND3 CCND2 NPPA MSX2 CCNK ZNF99 CCNT2 GEM ZNF92 CCNT1 GPRIN1 ZFHX3 AUTS2 IL2 IL3 BMP2 TCF3 SUPT16H LDB1 MYBL2 TGIF1 ZNF75CP GTF2F1 RBM14 GTF2F2 TGIF2 ELF1 ELF2 CAT RETN ZNF804B ZNF175 SERPINE1 SUPT4H1 ZSCAN32 JUNB NEDD4L ZNF169 RNF111 ZNF705G ZNF705D ZNF160 ZNF705A ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 NKX2-5 NR2C2AP ELOA2 ZNF383 ZNF140 SUPT5H CDC7 NR1D2 CDK9 ZNF37A ZNF702P ZNF138 TAF4B ZNF135 ZNF133 RARG BTG1 ELL TAF7L RSPO3 TEAD1 ELOA ZNF124 NELFB TEAD2 ELOB ZIK1 NELFCD TEAD3 NELFA TEAD4 ELOC TCF12 PAX5 NELFE TAL1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 CTDP1 ZNF582 PCGF6 CDKN2B TAF9 PCGF5 PCGF2 WWP1 TAF1L ZNF33B RYBP POLR2A ZNF337 POLR2B ZNF577 ZNF334 POLR2C ZNF333 POLR2D PF4 ZNF573 RXRB ZNF571 POLR2G CSF2 ZNF570 POLR2I TAF9B ITGA2B ZFP30 POLR2J ZNF569 ZNF568 ZNF567 ZNF566 TAF15 ZNF565 TAF12 ZFP37 TAF13 ZNF564 TAF10 ZNF563 TAF11 IGFBP1 SSRP1 ZNF562 TAF8 ZNF561 ZNF560 TAF7 NRBP1 ZNF559 TCEA1 ZNF558 TAF6 ZNF557 TAF5 ZNF799 TAF4 ZNF556 TAF3 ZNF555 ZNF554 TAF2 ZNF311 ZNF552 TAF1 ZNF793 G6PD ZNF551 ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL PLXNA4 ZNF300 ZNF782 ZNF540 ZNF658B ESRRB ESRRG ZFP69 CDK6 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 CYCS ZNF770 FKBP5 ZNF529 ZNF528 ZNF764 ZNF521 ZNF761 CR1 ZNF75D ZFP90 ZNF75A ZNF517 CRH ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 AXIN1 ZNF747 ZNF746 ZNF500 ZNF740 PPP2R5C KCNIP3 PPP2CA KLF4 PPP2CB RAD51 ZNF738 ZNF737 ZNF736 PPP2R1B ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 ZNF605 SOX9 ZNF600 ZNF839 INS TWIST2 TWIST1 ZNF726P1 OCLN CITED1 CITED2 CITED4 PARP1 KRABD5 KRABD4 KRABD3 GP1BA RET ZNF2 ZNF3 NPY CAMK4 GATA3 ZNF354C ZNF354B LMO1 LMO2 ATP1B4 LIFR KCTD6 NOP2 SMAD2 SMAD1 SMAD4 SMAD3 HNF4A PIP4K2A SMURF2 SMURF1 SMAD6 ESR2 PIP4K2B SMAD7 NR4A1 PIP4K2C NR4A3 JAG1 THRA CGB8 NR2E1 YBX1 OPRM1 CAMK2B ZNF197 CAMK2D ZNF195 CAMK2A NR2C2 THBS1 HSPD1 MED8 HES1 CAMK2G ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 PRDM1 MYC TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 PIP4P1 TFAP2A TFAP2B WWOX TFAP2C TFAP2D TFAP2E KCTD1 KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 ANAPC10 RELA ANAPC11 FZR1 CDC23 CDC26 CDC27 VENTX TCF7L2 ANAPC7 UBE2C CDKN2A UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 AKT2 AKT3 SFN ESRRA GPX2 GLS2 PRMT1 TXNRD1 STAT1 COX7A2L TJP1 IRAK1 CAV1 YWHAQ YWHAH PDPK1 ARNT2 BMAL1 PTPN11 COX7A2 COX7A1 CALM1 SLC2A3 CCNE2 CCNE1 POMC NLRC4 CASP1 TXNIP SKP2 MET MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 E2F1 TCF7L1 DLX5 JUN SOX2 SNW1 MAMLD1 MYB TSC2 TSC1 CDKN1B ZFPM1 GATA4 GATA2 GATA1 SOCS3 PTPN1 NFE2 CDK4 CDK2 TRPC3 TNFRSF10B FASLG TNFRSF10A FAS SOD2 IFNG PRKCQ PLK2 MDC1 ATF2 TP53RK NOC2L TP53AIP1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 RHNO1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 NUAK1 PCBP4 PRDX1 TP53BP2 ATRIP PRELID3A BANP BARD1 PLK3 PRELID1 CRADD GADD45A TPX2 RAD17 ATM CDK12 CDK13 ATR TP73 CDKN1A BTG2 BDNF SETD9 PRKAG1 CDK5R1 CHM BRCA1 GCK PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 RMI2 BRD1 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D SGK1 PCNA WRN MAPK1 PLAGL1 PERP PMS2 MAPK3 RICTOR BRD7 TIGAR NPM1 RPA1 RPA2 MLH1 HIPK1 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CCNA2 STEAP3 CCNA1 MRE11 SESN3 SESN2 MT-CO1 NBN KMT5A BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 PRKAB2 KAT6A MAPKAPK5 BLM NDRG1 SMYD2 SLC38A9 BCL2L14 MAP2K6 ZNF420 FANCI BRPF1 SCO2 BRPF3 TNFRSF10C FANCC MT-CO2 CNOT10 TNFRSF10D MT-CO3 CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 RHEB CNOT2 CNOT3 JMY MDM2 PIN1 MDM4 CNOT8 RAD9B CNOT9 RAD9A PRR5 PPP1R13B DYRK2 TRIAP1 PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA PRKAG2 RBL2 RBL1 MED15 BIRC5 TMEM219 PRKAA1 RNF34 AURKB TP53INP1 RBBP8 E2F4 RFFL E2F7 E2F8 ARID3A MTOR PML RAD50 BAX MED26 HDAC10 EPC1 MED25 PPARD PRMT6 PBRM1 ACTL6B YEATS4 ARID2 HDAC4 THRB UBE2I VDR NR1H2 RORA NR3C1 ESR1 KDM5B NR2C1 NR5A1 NR4A2 AR G6PC1 RXRA SUMO1 SP1 RARA PPARG PGR PPARA HDAC8 TP53 REST PTEN CSNK2A1 CSNK2A2 RRM2B CSNK2B PRKAA2 KIT BRIP1 APOE PCK1 PRKCB MYL9 COX7B COX7C GPAM COX8A SREBF1 COX8C ERBB2 EGFR YWHAE COX5B COX5A PPP2R1A PRKACA COX6C YWHAG SKP1 COX6A1 COX6A2 USP9X UBA52 COX6B2 COX6B1 CPAP CUL1 AURKA CCNB1 UBB UBC HIGD1C RPS27A CDK1 BCL2L11 PMAIP1 BID BBC3 RRM2 CARM1 SRC SRF GLS CTSV NAMPT GAMT CTSL CTSK CGA NR1D1 MMP13 GPI FURIN SPP1 RB1 SMARCB1 CCNH EHMT2 H2AC19 EHMT1 CCNC H2AC14 TRIM28 H2BC12L MED1 SMARCC1 SMARCC2 MED4 MED6 MED7 ZNF28 ZNF273 ZNF708 PPARGC1A PPARGC1B ZNF264 CREBBP ZNF141 H4C9 ZNF382 SETD1B SETD1A SMARCA2 SMARCA4 H2AC20 ZNF30 ZNF136 ZNF257 EZH2 H2AX PHF20 ASH2L MED16 MED17 MED12 MED14 MED13 MED10 H3-3B LBR H3C8 ACTL6A MED27 SIRT1 MED23 NCOR2 KAT2B KAT2A H2AJ MED24 NCOR1 MED20 GPS2 H3C15 TBL1X ZNF224 MBD3 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GATAD2B GATAD2A ZNF33A ZNF354A ZNF454 ZNF331 H2AB1 EP300 ZNF324 MEN1 ZNF320 H2AC8 ZNF680 H2AC6 H2AC7 TBL1XR1 ZNF317 KMT2D KMT2A TXN KMT2C KMT2B MED30 MED31 ZNF669 ABL1 ZNF547 ZNF425 HDAC11 BMI1 CBX5 YY1 CBX3 CDK8 RING1 CDK7 CDK5 MAF ZNF418 HDAC5 ZNF778 HDAC9 MNAT1 RNF2 HDAC6 HDAC7 GSK3B DPY30 CBX8 CHD4 CHD3 PHC2 CBX6 PHC1 H2BC26 SIN3B CBX4 CBX2 NFATC2 SIN3A ZNF649 H2BC21 NFYA PHC3 NFYB NFYC WDR5 TBP EED ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 ZNF519 H2BC11 COXFA4 SMARCD1 HDAC2 SMARCD2 HDAC3 TCF7 SMARCD3 HDAC1 RBBP4 RBBP5 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2K POLR2L SMARCE1 H2AZ2 DEK COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis TMEM126A NDUFAF8 TMEM126B NDUFAF6 NDUFAF7 DMAC1 NDUFAF4 DMAC2 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFV3 NDUFA3 NDUFV2 NDUFA2 NDUFA1 NDUFV1 SFXN4 MT-ND6 LYRM2 MT-ND4 MT-ND5 MT-ND2 TMEM186 MT-ND3 MT-ND1 COA1 OXA1L NDUFS8 NDUFS7 NDUFS6 HSPA9 NDUFS5 NDUFS4 NDUFAB1 NDUFS3 NDUFS2 NDUFS1 FOXRED1 TIMMDC1 NDUFA13 NDUFA11 NDUFA12 NDUFA10 HSCB NDUFB10 NDUFC2 NDUFB11 NDUFC1 ACAD9 PYURF ECSIT NUBPL NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CRTC1 CIPC TFEB PER2 NPAS2 PER1 RBM4 CLOCK PER3 DBP BMAL1 BHLHE40 CRY2 RORA CRY1 SIK1 RORC KMT2A NR1D1 CREBBP TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion ELAC2 TRNT1 HSD17B10 TRMT10C PRORP COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway APP SDC1 SERPINE2 PROS1 ITGB3 SERPINA10 F13A1 SERPINA5 THBD PF4V1 CD177 FGB FGA GP1BB FGG HSPG2 F2R F2 F3 F5 SERPINE1 F7 PROCR F8 F9 SERPING1 SERPINC1 PROZ ANO6 KNG1 F10 SERPIND1 F12 F11 GP5 ANO5 PRTN3 GP9 PROC F13B SMPD1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN GP1BA ADAMTS13 VWF PF4 ITGA2B SDC4 KLKB1 SDC2 SDC3 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling SLC25A14 UCP3 UCP2 SLC25A27 PM20D1 UCP1 SLC25A4 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle ERCC3 ERCC2 CCNK CCNT2 NUP107 CCNT1 NUP188 GTF2B RCC1 SUPT16H NUP210 GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 POM121 TSG101 SUPT4H1 NEDD4L AAAS GTF2E1 GTF2E2 NUP160 POM121C NUP85 TPR NUP88 NUP155 VTA1 ELOA2 NUP153 SUPT5H CDK9 CHMP2B CHMP2A NMT1 TAF4B NMT2 ELL TAF7L NUP62 ELOA NELFB ELOB NELFCD NELFA ELOC NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 NCBP2 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 CHMP3 UBA52 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A TAF1L POLR2A UBB POLR2B NUP42 POLR2C POLR2D UBC MVB12B MVB12A POLR2G NUP43 POLR2I RPS27A TAF9B POLR2J RAE1 GTF2H1 RANBP2 GTF2H2 RANBP1 GTF2H3 RNGTT GTF2H4 TAF15 GTF2H5 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 UBAP1 TAF7 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 RAN TAF2 NUP37 TAF1 PPIA XPO1 NUP214 CDK7 MNAT1 TBP FURIN POLR2E POLR2F POLR2H CCNH POLR2K POLR2L SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins IKBKE EIF2AK2 TOPORS PIAS4 IKBKG SUMO1 PIAS3 SUMO3 UBE2I RELA NFKB2 NFKBIA PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage GMPR APRT ADA ADK AMPD1 HPRT1 AMPD2 AMPD3 DCK GMPR2 PNP DGUOK MAPDA CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase CALM1 PRKAR1B PRKAR2A PRKAR1A PRKX PRKAR2B PRKACG PRKACA PRKACB ADCY1 ADCY8 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins ADAMTS16 ADAMTS18 NOTCH2 NOTCH3 NOTCH4 SEMA5A POMT2 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL1 ADAMTS4 ADAMTS2 ADAMTS5 C1GALT1C1 MUC13 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 MUC15 THSD7A ADAMTS6 ADAMTS8 ADAMTS7 SBSPON ADAMTS9 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 MUC19 C1GALT1 NOTCH1 SSPOP MUC5B ADAMTS13 MUC20 MUC21 LFNG B4GAT1 DAG1 LARGE1 POMGNT1 THBS1 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication RPL24 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 RPL10L RPL10A RPS4X RPL41 NUP210 RPS3A GTF2F1 RPL3L GTF2F2 NUP93 RPL23A NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 HSP90AA1 RPL10 NUP62 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 NDC1 RPL19 SEC13 NUP133 RPL27A RPL13A RPS15 RPS14 NUP50 RPS17 UBA52 NUP54 RPS16 RPS19 RPS18 RPS11 RPS10 POLR2A RPS13 POLR2B NUP42 RPS12 POLR2C POLR2D IPO5 GRSF1 POLR2G RPLP1 DNAJC3 NUP43 RPLP0 POLR2I RPS27A POLR2J RAE1 RANBP2 RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 NUP35 NUP37 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A NUP214 RPL36A RPL35A RPL22L1 RPS27L RPS15A RPS3 RPS2 PARP1 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 POLR2E POLR2F POLR2H RPL21 RPL23 RPL22 POLR2K POLR2L RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures SEM1 RMI2 RMI1 TOP3A RAD51D RTEL1 RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 MUS81 BRCA2 RAD51AP1 SLX4 EME1 BRIP1 EME2 FIRRM RBBP8 ATM FIGNL1 GEN1 SLX1B BLM XRCC2 XRCC3 PALB2 SPIDR RAD50 BRCA1 RAD51 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action CUL1 IFIT1 IFIT3 SKP1 IFIT2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) VPS25 HGS STAM2 VPS37C VPS37D VPS37A VPS37B CHMP3 UBA52 CHMP6 CHMP7 CHMP5 CHMP4C VPS4B CHMP4B CHMP4A VPS4A VPS28 TSG101 UBB STAM UBC MVB12B MVB12A RPS27A VTA1 CHMP2B CHMP2A UBAP1 VPS36 SNF8 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP7A NEDD4L TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 ATP2B4 ATP2A3 MCOLN3 ATP2A2 TRPC6 TRPC3 ATP2B3 ATP2A1 TRPA1 TRPC4 ATP2B2 TRPC1 ATP2B1 TRPV2 SRI TRPV3 CALM1 TRPV1 MCOLN1 MCOLN2 TRPC4AP ATP6V1H TRPV6 TRPV4 TRPV5 PDZD11 UBA52 WWP1 UBB UBC RPS27A ATP6AP1 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLN ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP11C ATP11B ATP1B3 ATP11A ATP1B2 ATP1B1 STOM SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A ATP6V0D1 RAF1 ATP6V0D2 ATP6V1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 ANO8 ATP6V0A2 ANO9 CLCA1 ANO6 ATP6V0A4 ASIC2 ANO7 ASIC3 ATP6V1D ANO4 ATP6V1C1 CLCA4 ANO5 ATP6V1F ATP6V1C2 ANO2 ASIC1 ATP6V0A1 ANO3 ATP8B4 ATP8B3 ANO1 ATP8B2 ATP8B1 ATP4B ATP4A FXYD4 WNK1 FXYD3 WNK2 FXYD2 WNK3 FXYD1 FXYD7 FXYD6 CUTC ANO10 RYR1 RYR2 TCIRG1 RYR3 UNC80 ATP7B CLIC2 ATP6V0B TSC22D3 SGK1 TRDN ASPH ATP6V1B2 SGK3 SGK2 ATP6V0C ATP6V1B1 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ATP6V0E2 ATP6V1G3 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 CAMK2B ATP13A5 ATP13A2 CAMK2D UNC79 CAMK2A CAMK2G TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) ARHGEF18 UBB SMURF1 UBC TGFBR1 TGFBR2 PRKCZ RHOA RPS27A CGN PARD6A UBA52 F11R FKBP1A PARD3 TGFB1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection GNAT3 GNAZ CD3G FCGR3A SYK FGR HCK ADORA2B GNAI3 FYN FCGR1A FCGR2A PLCG2 AHCYL1 PLCG1 GNAI1 GNAI2 PRKX PRKACA CALM1 IL6 IL10 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 GNG10 IGHV3-33 PRKAR2B V2-15 IGKV1D-39 V2-19 IGKV1D-33 GNG12 GNG11 IGKV2D-28 GNG13 IGKV4-1 IGHV7-81 GNB2 ITPR1 GNB1 V1-11 ITPR2 IGKV2D-30 V1-16 GNB4 V1-13 ITPR3 GNB3 IGHV4-59 IGHV1-69 GNB5 GNGT1 IGLV2-11 IGLV1-40 IGLV1-47 GNGT2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 GGT1 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 DPEP2 IGHV3-13 DPEP1 CD163 IGKV1D-16 PLK2 IGLV7-43 IGKV1D-12 RHBDF2 MYH9 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 GNG3 IGHV4-39 IGKV2-29 IGKV2-28 GNG2 IGLC3 GNG5 IGLC1 GNG4 IGLC2 GNG7 V1-9 V5-4 GNG8 V1-7 GGT5 V5-1 V1-5 V1-3 IGKV3D-20 ADAM17 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAPK14 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A FURIN GNAS YES1 IGHG3 IGHG4 CYSLTR1 IGHG1 CYSLTR2 IGHG2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 NRAS PIK3R1 MKNK1 SPRY2 MAPK1 FRS2 BRAF MAPK3 PIK3CA FGF1 FRS3 FGF4 FGF16 UBA52 FGF9 FGF18 FGF20 SOS1 FGF23 CBL FGF2 GALNT3 GAB1 UBB PLCG1 UBC RPS27A PTPN11 PPP2R1A PPP2CA HRAS PPP2CB TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 TLR9 PELI1 LRRC14 TRAF6 USP14 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 PPP2R1A BTRC RELA SKP1 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 PPP2R5D TLR7 MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 MAPK3 MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation FGF1 FGF22 TGFBR3 FGF3 GIPC1 FGF10 FGF2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism PNPLA4 PNPLA5 PRKACG CAV1 GPAT2 PRKACB AGMO MOGAT3 MOGAT2 MOGAT1 PPP1CC GK3 GPAM GK2 GK FABP12 FABP9 PLIN1 FABP1 LPIN1 LPIN2 FABP2 LPIN3 FABP3 FABP5 FABP6 FABP7 PPP1CB DGAT2 DGAT1 PLIN3 ABHD5 PRKACA FABP4 PPP1CA GPD2 MGLL LIPE ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism GLUL SLC1A2 SLC1A3 SLC38A1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU FURIN MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein GSK3A GSK3B PARP6 PARP8 PARP4 SUMO1 PARP16 PARP14 PARP10 UBE2I PARP9 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism ACSS3 HMGCS2 ACAT1 BDH2 HMGCLL1 BDH1 OXCT1 HMGCL OXCT2 AACS RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs CDH1 CALM1 MEN1 CLIP1 RAC1 CDC42 IQGAP2 CTNNA1 IQGAP3 IQGAP1 CTNNB1 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D CALHM1 SCNN1B SCNN1A CALHM3 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation ST8SIA3 MGAT5 B4GALT1 B4GALT2 ST6GAL1 B4GALT3 B4GALT6 B4GALT4 MGAT4C B4GALT5 MGAT4A MGAT4B ST8SIA6 ST3GAL4 ST8SIA2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 NUP205 POM121 CCNB2 CCNB1 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NEK9 NUP88 NEK6 NEK7 RAE1 RANBP2 NUP155 NUP153 CDK1 NUP35 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A AKT1 FOXO1 AKT2 AKT3 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry GPC1 CTSL GPC3 FURIN GPC2 GPC5 GPC4 GPC6 SDC1 ACE2 SDC4 NRP1 AGRN SDC2 VCP SDC3 TMPRSS2 HSPG2 HAVCR1 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR FDX2 CYP11A1 FDXR FDX1 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BCL2 AKT1 ELK1 CDKN1B EGF PTK2 AREG EGFR FOS TGFA EREG UHMK1 BTC MAPK1 EPGN MAPK3 SRF FOXO3 HBEGF AKT2 AKT3 XPO1 CCND1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism GPC1 CTSL EXT2 GPC3 HS3ST3A1 GPC2 IDUA GPC5 HS2ST1 GPC4 GPC6 SDC1 SGSH SLC35D2 EXTL2 IDS AGRN EXTL3 HSPG2 HPSE NAGLU HS3ST5 HS3ST6 HS3ST4 NDST2 HS3ST1 NDST1 HS3ST2 NDST4 NDST3 HS3ST3B1 SDC4 HS6ST1 HS6ST2 HPSE2 SDC2 HS6ST3 SDC3 GLCE EXT1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis VAMP2 OCRL AP4E1 DNM2 ARRB1 CLINT1 AP1G1 FTH1 SH3GL2 AP1S2 AP1S1 AP1S3 AP3S1 HSPA8 SH3D19 TPD52 AP1B1 PIK3C2A AP3B1 VAMP8 GAK DNAJC6 FTL NAPA RAB5C BLOC1S4 TGOLN2 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 SNX9 SNX5 AP1M2 TXNDC5 AP1M1 TBC1D8B SNAPIN SORT1 DTNBP1 HIP1R PUM1 CPD TPD52L1 AP4B1 IGF2R NECAP1 GOLGB1 VAMP7 YIPF6 ACBD3 PICALM ARF1 TFRC THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DUOXA1 DUOXA2 IYD TXNDC11 CAV1 TPO CGA DUOX1 SLC5A5 DIO1 DUOX2 TSHB DIO2 DIO3 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 CSF2RB SFTPA1 CSF2RA SFTPD SFTPB SFTA3 SFTPA2 SFTPC RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes YWHAE CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 NUMA1 TUBG2 MZT2B HAUS8 MZT2A PRKAR2B NME7 HAUS7 TUBGCP2 CEP70 MZT1 CEP72 TUBGCP5 CEP192 TUBGCP6 PCNT TUBGCP3 TUBGCP4 CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling RHOA ARHGEF6 GNG3 BTK GNG2 GNG5 PAK1 GNG4 GNG7 PDPK1 CDC42 GNG8 PIK3CG AKT2 AKT3 AKT1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 PLCB3 GNB5 PIK3R6 PIK3R5 GNGT1 PLCB1 PLCB2 GNGT2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling STAT3 ADAM17 PTPN1 IRS1 LYN JAK2 STAT1 CISH CSH1 MAPK1 IRS2 PRL PRLR MAPK3 GHR PTPN6 GH2 SOCS2 STAT5A GH1 SOCS1 STAT5B SOCS3 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis PDSS2 PDSS1 HPDL COQ8B COQ8A COQ9 COQ7 STARD7 COQ6 COQ5 COQ4 COQ3 COQ2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling DAAM1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B PLCB3 PLCB1 PLCB2 CALM1 PRKG2 TCF7L2 UBA52 PSMD12 PSMD11 UBB GNG10 PSMD14 PSMD13 UBC LEF1 GNG12 GNG11 PSMA7 GNG13 PSMB6 RPS27A PSMD8 GNB2 ITPR1 GNB1 PSMB7 ITPR2 PSMB4 PSMD6 GNB4 PSMB5 PSMD7 ITPR3 GNB3 PSMB2 GNB5 PSMB3 PSMD2 GNAT2 PSMD3 PRKCG PSMB1 PSMD1 WNT5B GNGT1 WNT5A ROR1 ROR2 GNGT2 NLK ADRM1 PPP3R1 WNT1 PSMA5 FZD1 SEM1 DVL1 FZD3 PSMA6 DVL2 FZD2 PSMA3 FZD5 PSMC5 DVL3 FZD4 PSMA4 FZD7 PSMC6 FZD6 FZD8 PSMC3 GNAO1 PSMA1 CLTB PSMA2 ARRB2 PSMC4 PPP3CA PSMC1 PPP3CB PSMC2 PRKG1 CTNNB1 PRICKLE1 PDE6B PDE6A GNG3 PDE6G RYK GNG2 GNG5 GNG4 GNG7 GNG8 PRKCA CLTC CLTA AP2A1 AP2B1 AP2A2 AP2S1 PARD6A TCF7L1 NFATC1 RAC1 SCRIB RHOA VANGL2 PFN1 MAP3K7 WNT11 TCF7 SMURF2 SMURF1 WNT4 RAC2 RAC3 CAMK2A PRKCB GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation DNM1 DNM2 MYO6 DAB2 GJA1 CLTCL1 CLTC CLTB CLTA RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription CBFB KCTD6 RUNX1 AXIN1 GPAM ESR1 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) NFATC1 RUNX3 IL12RB2 TBX21 RUNX1 CCL3 TNF TPST2 IFNG STAT4 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease PPM1K BCKDHA BCKDHB DLD DBT NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants ALK P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MDM2 MDM4 CHEK2 COP1 ZNF385A TP53 PCBP4 ATM PHF20 CDKN1A CDKN2A CDKN1B UBA52 CCNE2 CCNE1 PSMD12 PSMD11 UBB PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport IFT172 IFT52 IFT57 DYNC2H1 IFT140 DYNLL1 WDR35 KIFAP3 IFT88 DYNC2I2 DYNC2I1 IFT70B IFT70A TRAF3IP1 DYNLT2B KIF17 DYNC2LI1 IFT74 KIF3A IFT56 KIF3B TTC21B DYNLT5 TNPO1 DYNLT2 IFT80 KIF3C IFT20 WDR19 IFT22 IFT122 IFT43 IFT81 IFT27 TRIP11 DYNLRB2 DYNLL2 DYNLRB1 IFT46 CLUAP1 IFT25 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants APC PPP2R1B PPP2R5E CSNK1A1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha NR1H4 CLOCK NR1H3 G0S2 MED1 ACSL1 MED4 MED6 MED7 THRAP3 CDK19 PEX11A PPARGC1A PPARGC1B CREBBP FAM120B ARNT2 CYP1A1 SREBF2 BMAL1 MED19 MED15 MED18 MED11 MED16 MED17 MED12 MED14 MED13 MED26 MED10 CD36 MED29 MED28 MED22 HMGCS2 NCOA1 NCOA2 MED25 NCOA6 MED21 NCOA3 ABCB4 HMGCS1 APOA2 APOA1 MED27 RGL1 MED23 APOA5 NCOR2 AGT MED24 NCOR1 MED20 AHR PLIN2 UGT1A9 ABCA1 ANGPTL4 ACADM GPS2 TBL1X SLC27A1 RXRB FADS1 EP300 ESRRA CPT1A NRF1 TIAM2 NPAS2 NR1H2 RORA CYP4A11 TBL1XR1 HELZ2 RXRA MED30 SP1 MED31 PPARG PPARA TGS1 FABP1 ALAS1 TXNRD1 CDK8 CHD9 CPT2 CYP7A1 CARM1 SIN3A TNFRSF21 NFYA NFYB NFYC GRHL1 FDFT1 NR1D1 FHL2 ME1 ARNT HDAC3 SMARCD3 TRIB3 SULT2A1 MTF1 AHRR GLIPR1 MED8 CCNC MED9 ANKRD1 MED13L ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets PPP2R1B ELK1 MAPK7 RPS6KA3 DUSP4 RPS6KA5 DUSP3 RPS6KA2 VRK3 RPS6KA1 DUSP6 DUSP7 MEF2A MEF2C MAPK1 PPP2R1A MAPK3 PPP2R5D MAPK14 PPP2CA MAPK11 PPP2CB DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma CYP1B1 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions LGI1 LGI4 LGI3 LGI2 DLG4 ADAM11 ADAM22 STX1B STX1A CACNG8 ADAM23 CACNG2 CACNG3 CACNG4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism PC BTD PCCA HLCS MCCC1 PCCB ACACA MCCC2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation RNF19B UBE3A UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA6 UBA5 CUL2 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H UBE2B LRRC41 KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 BTRC UBE2W UBOX5 UBE2D1 MKRN1 ANAPC10 UBE2U RNF182 ANAPC11 UBA3 SKP1 UBE2O FZR1 CDC23 TPP2 CDC26 BLMH CDC27 UBA1 UBE2K UBE2M ANAPC7 TRIM71 FBXW11 UBE2C RNF14 KBTBD13 UBE2E1 UFL1 UBE2Q1 UBE2Q2 UBE2S TRIM69 CDC16 UNKL ANAPC4 DTX3L ANAPC5 PJA2 ANAPC1 PJA1 ANAPC2 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 ASB13 ASB14 RNF6 ASB11 UBA52 ASB12 UBE2D2 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 CUL1 FBXL20 ZNRF1 ZNRF2 PSMD12 HECTD1 PSMD11 UBB HECTD2 HECTD3 PSMD14 ASB10 PSMD13 TRIM41 UBC RNF25 FBXL19 FBXL18 CDC34 PSMA7 FBXL15 FBXL16 PSMB6 RPS27A FBXL13 PSMD8 UBE2D3 FBXL14 FBXL12 PSMB7 TRIM39 PSMB4 ASB8 PSMD6 ASB9 PSMB5 LNX1 PSMD7 ASB6 PSMB2 ASB7 PSMB3 TRIM36 PSMD2 ASB4 PSMD3 TRIM37 PSMB1 ASB5 PSMD1 ASB2 ASB3 TRIM32 ASB1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 TRIM4 FBXO32 TRIM63 RBBP6 RBX1 STUB1 CDC20 ITCH SH3RF1 UBE2V1 CUL3 KBTBD7 UBE2N NEDD4L RNF111 VHL RNF34 ELOB ELOC FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 WWP1 FBXL3 FBXL5 SOCS1 SKP2 UBA7 UBE2L6 HERC5 LRR1 CCNF KEAP1 CBLB UBE2L3 DCAF1 HERC4 RNF115 HERC3 RNF114 HERC2 HERC1 FBXO7 TRIM21 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 MIB2 ATG7 HACE1 RBCK1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 SOCS3 DZIP3 FBXL7 KCTD6 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B SMURF2 GAN SMURF1 PRKN RNF138 RNF130 HUWE1 KLHL2 UBE2G1 KLHL3 UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 LTN1 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors DRD3 DRD4 DRD5 DRD1 DRD2 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin ALDH2 SLC6A4 MAOA ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT2 STAT3 SPHK1 SKIC2 TCP1 GBA1 USP11 DCAF7 CCT6B AP3M1 FBXO4 LONP2 FBXO6 FBXW4 FBXW5 FBXW10 CCT8 FBXW7 CCT7 FBXW9 CCT5 CCT4 FBXW2 NOP56 CCNE2 ARFGEF2 CCNE1 XRN2 GAPDHS TP53 FKBP9 HDAC3 CCT6A FBXL3 FBXL5 WRAP53 KIF13A CCT3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion GNG3 GNG2 GNG5 GNG4 GNG7 ADRA2C ADRA2A GNG8 ADCY6 ADCY5 GNG10 CACNA1D CACNB2 CACNA1C CACNB3 GNG12 GNG11 GNG13 GNB2 GNAI1 GNAI2 GNB1 GNB4 GNB3 GNB5 CACNA2D2 GNGT1 GNGT2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency GSS DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death H2AC14 H2BC12L GOLGA2 RIPK3 H2AC8 CDC25A APP CDC25B H2AC6 PRIM2 H2AC7 PRIM1 MLKL POLA1 POLA2 GSDME CAPNS1 CAPNS2 DNMT1 CAPN2 CAPN1 CAST FOXO3 H4C9 TP53 PRDX2 PRDX1 YWHAE CDK5 H2AC20 EZH2 H2AX CDK5R1 H2BC26 JUN H2BC21 H3-3B DNMT3B H3C8 CDKN2A TRADD LMNB1 EED FASLG DNMT3A TRAF2 H2BC17 CASP8 H2BC12 H2BC13 H2BC14 H2BC15 RIPK1 H2AJ FADD H2BC11 SOD2 H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 H2BC1 CDC25C C1QBP RBBP7 H2AC19 H2AB1 BCL2L11 H2AZ2 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism ACOT2 ACOT1 HSD17B12 SCD DBI THRSP ACOT4 ACSL1 SLC25A20 LTA4H MMAA CROT ALOX12B CYP4F2 CYP4F3 CYP4F8 OLAH PRXL2B CYP1A1 ACOT7L SCD5 CYP2C9 CYP2C8 EPHX2 HSD17B3 ACAD11 HSD17B4 ALOX5 ACAD10 CYP1A2 PRKAG2 HSD17B8 ABCD1 ACBD7 CYP8B1 ACBD6 NUDT7 ACBD5 ACBD4 NDUFAB1 ACSF3 HACD1 ACSF2 ELOVL5 ACADVL FAAH2 ACSBG1 HACD3 HACD2 ACSBG2 ACOT11 ACOT12 ACOT13 HACD4 TECR PPARD ACADL HAO2 ABCC1 ACADM ALOXE3 ACADS PTGIS CRAT SLC27A1 FADS2 EHHADH NUDT19 FADS1 PON3 HPGD AKR1C3 ELOVL1 PON2 PON1 ELOVL4 LTC4S CYP4F22 ELOVL2 ACLY SLC27A3 ELOVL3 SLC27A2 ACAA2 ELOVL6 ELOVL7 CYP4A22 PTGR1 ACOXL PTGR2 GGT1 CPT1A ACAA1 CYP2C19 TECRL CPT1B CYP4F11 ALOX5AP CYP2U1 DPEP2 DPEP1 CYP4A11 SLC22A5 ACOX2 PTGS2 ACOX3 PTGS1 GPX2 PCCA GPX1 GPX4 RXRA PCCB ACACA TBXAS1 GGT5 ECHS1 CBR1 MORC2 MAPKAPK2 PECR CPT2 HPGDS FAAH ACSM3 ACSM6 CBR4 PTGDS ACSL6 PTGES2 ACSL5 PRKAA2 PTGES3 THEM5 THEM4 HACL1 AWAT1 MID1IP1 CYP4B1 PTGES MCAT HADH ECI1 PHYH PPT1 PPT2 ALOX15 ALOX12 PCTP HTD2 CYP1B1 MCEE SLC25A17 CYP2J2 SCP2 MMUT ALOX15B PLA2G4A ACOT9 PRKAB2 ACOT8 MECR ACOT7 DECR2 FASN HADHB HADHA DECR1 ACSL4 AMACR ACSL3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors GRIA1 GRIP1 EPB41L1 MDM2 GRIA2 TSPAN7 MYO6 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 AKAP5 PRKCA AP2A1 DLG4 CAMK2B CAMK2D CACNG8 CAMK2A CACNG2 CACNG3 PRKCG CACNG4 CAMK2G PRKCB ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors ADORA2B ADORA2A ADORA3 ADORA1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 NRAS PIK3R1 MKNK1 SPRY2 FRS2 PIK3CA GTF2F1 GTF2F2 TIAL1 PTBP1 FGF6 RBFOX2 HNRNPH1 ESRP2 ESRP1 GAB1 HNRNPA1 TIA1 HNRNPM PLCG1 PTPN11 PPP2R1A FGFBP1 FGF7 FGFBP2 FGFBP3 FGF22 FGF3 FGF10 PPP2CA PPP2CB NCBP1 NCBP2 MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 UBA52 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HNRNPF CBL FGF2 POLR2A UBB POLR2B POLR2C POLR2D UBC POLR2G POLR2I RPS27A POLR2J POLR2E POLR2F POLR2H POLR2K POLR2L HRAS RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 TBP GTF2B GTF2A1 GTF2F1 GTF2A2 GTF2F2 TAF9 TAF1L POLR2A POLR2B POLR2C GTF2E1 POLR2D GTF2E2 CDK7 POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH TAF8 POLR2K POLR2L TAF4B TAF7 TAF6 TAF7L TAF5 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 MDM2 JUP CTNNA1 CTNND1 MTBP RACK1 CBLL1 EPS15 BANP DNM2 SRC CTSS CTSL CTSB UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis VAV2 CD3G PIK3R2 FCGR3A SYK PIK3CB FGR PIK3R1 HCK FYN FCGR1A FCGR2A PLCG2 HSP90AB1 PIK3CA NCKAP1L WAS PAK1 CDC42 ARPC1B ARPC1A AHCYL1 PLCG1 MYO9B ACTG1 HSP90AA1 CFL1 ABI2 WASL ABI1 IGHV3-23 NCKIPSD IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 ITPR1 V1-11 ITPR2 IGKV2D-30 V1-16 V1-13 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 NF2 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 LIMK1 BRK1 V1-7 V5-1 ABL1 V1-5 V1-3 IGKV3D-20 NCK1 V5-6 ACTR3 IGLV3-19 IGKV2-30 ACTR2 IGHV2-70 PRKCD IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 PRKCE IGKC PLPP5 IGKV1-39 PLPP4 IGLV3-21 MYO5A IGKV1-33 MYH2 V4-6 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 WASF1 WASF2 WASF3 BAIAP2 PLD4 RAC1 PLA2G6 PLD1 PLD3 PLD2 MAPK1 MAPK3 ELMO1 BTK ELMO2 DOCK1 CRK PTK2 CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 YES1 VAV3 IGHG3 IGHG4 IGHG1 ACTB IGHG2 VAV1 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope CAPNS1 JUP CAPN1 DSG2 TCHH PCSK6 TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ LIPN LIPM PRSS8 LIPK TGM5 RPTN CELA2A SPINK6 SPINK5 DSP KAZN LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A PI3 LCE6A PKP2 PKP1 LORICRIN PKP3 SPINK9 DSG3 PERP DSG4 DSC1 DSC2 IVL DSC3 DSG1 FLG PKP4 SPRR2E SPRR2F SPRR3 CSTA SPRR2G KLK5 KLK8 PPL EVPL LCE2D LCE3C LCE3D LCE3A FURIN LCE3B LELP1 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK13 KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response CDKN2A CASP3 APAF1 APIP CYCS GSDME MAPK1 XIAP UACA C1QBP MAPK3 AVEN GSDMD DIABLO CARD8 CASP9 CASP7 BAK1 BAX NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase PDE2A NOS2 IRAG1 PRKG2 PDE11A PDE10A NOS3 KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 NOS1 PDE5A PDE9A ITPR1 GUCY1A2 GUCY1A1 GUCY1B2 GUCY1B1 PDE1B PDE1A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere H2AC14 H2BC21 H3-3B H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 ATRX TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP H2BC14 H2BC15 H2AJ DAXX H2BC11 H4C9 POLR2A POLR2B POLR2C POLR2D H2BC9 H2BC8 POLR2G H2BC5 H3-4 POLR2I H2BC3 H2AC20 POLR2J H2BC1 H2AX POLR2E POLR2F POLR2H H2AC19 POLR2K POLR2L H2BC26 H2AB1 H2AZ2 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling HGF PIK3CA GAB1 MET PIK3R1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B DYNC1I1 CENPE NUF2 NUDC NUP160 NUP85 DYNLL2 BIRC5 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L ZWILCH ANAPC15 ANAPC16 CENPA UBE2D1 ANAPC10 CENPC ANAPC11 CDC23 CDC26 CDC27 KNTC1 ANAPC7 UBE2C UBE2E1 CENPT CENPU UBE2S CDC16 SGO1 ANAPC4 SEC13 SGO2 ANAPC5 ANAPC1 ANAPC2 NUP133 DYNLL1 CKAP5 CENPF CENPH RANGAP1 PMF1 MAPRE1 CENPI TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CENPP CENPQ CENPS NUP43 CLASP1 RANBP2 DYNC1H1 NDE1 PLK1 CLIP1 MAD1L1 NUP37 ITGB3BP NDC80 RPS27 BUB1 CLASP2 XPO1 SPDL1 NSL1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E KNL1 ZW10 DSN1 BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 KIF18A NDEL1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals SRC UNC5A UNC5B DCC UNC5C UNC5D NTN1 PTPN11 PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy ATM UBB UBA52 UBC NBR1 PEX5 USP30 EPAS1 SQSTM1 MAP1LC3B RPS27A TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism HPD GSTZ1 FAH HGD TAT SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants FLT3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L RPL37A RPL23A ZNF598 ASCC2 ASCC3 RPL36A RPL35A RPL22L1 UBE2D1 RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 UBE2D2 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 UBB RPL36 RPS12 RPSA UBC RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A UBE2D3 RPL37 RPL39 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD2 FASTKD5 TBRG4 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 AKT1 TRIM27 USP13 PTEN TNKS TNKS2 RNF146 FRK OTUD3 CSNK2A1 CSNK2A2 MKRN1 CSNK2B WWP2 XIAP STUB1 UBA52 AKT2 AKT3 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 NEDD4 PREX2 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs CALM1 GIT1 RAC1 CAMK1 CAMKK1 CAMKK2 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection MAPK8 PLCG2 NCKAP1L CDC42 NOX1 ARPC1B ARPC1A PLCG1 GNAI1 GNAI2 PRKX PRKACA RELA NFKB1 IL6 ABI2 IL10 ABI1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 PRKAR2B V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 ITPR1 V1-11 ITPR2 IGKV2D-30 V1-16 V1-13 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 DVL1 IGKV3-11 LYN DVL2 V2-8 V1-20 DVL3 IGKV2D-40 IGHV3-11 IGHV3-13 CD163 IGKV1D-16 PLK2 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 RHBDF2 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 NOXA1 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 BRK1 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 ADAM17 NCK1 IGLV3-19 ACTR3 IGKV2-30 ACTR2 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 V4-6 MYH2 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAPK14 WASF1 WASF2 WASF3 PRKACG CTSG BAIAP2 PRKACB MAPK1 ADCY9 PRKAR1B HMOX1 MAPK3 PRKAR1A BTK ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A FURIN PTK2 GNAS GSDMD YES1 VAV3 IGHG3 IGHG4 CYSLTR1 IGHG1 ACTB CYSLTR2 VAV1 IGHG2 GNAT3 VAV2 GNAZ CD3G NLRP3 FCGR3A SYK FGR HCK ADORA2B GNAI3 FYN C3 FCGR1A FCGR2A HSP90AB1 WAS NOXO1 AHCYL1 MYO9B ENTPD1 C3AR1 ENTPD5 IL18 IL1A IL1B P2RX4 ACTG1 CALM1 CYBA WASL NCKIPSD GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 WNT5A GNGT2 GGT1 FZD7 DPEP2 MEFV DPEP1 NFKB2 P2RX7 PYCARD PSTPIP1 CASP1 TXNIP GNG3 TXN SUGT1 GNG2 GNG5 GNG4 GNG7 GNG8 GGT5 ABL1 NT5E JUN RAC1 ELMO1 ELMO2 DOCK1 CRK CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism ST8SIA5 ST3GAL1 ST8SIA3 ST3GAL2 ST3GAL3 CTSA GLB1 ST6GALNAC2 ST3GAL5 ST6GALNAC3 ST6GALNAC4 ST6GAL1 SLC35A1 NEU2 NEU3 ST6GALNAC5 ST6GALNAC1 NEU1 ST6GALNAC6 CMAS NPL NANP NEU4 ST8SIA4 ST3GAL6 NANS ST6GAL2 ST8SIA1 SLC17A5 ST8SIA6 GNE ST3GAL4 ST8SIA2 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling STAT3 EP300 CD274 HDAC2 DNMT1 HDAC3 HDAC1 PRDM1 IL2RG HIF1A SIN3A 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC1 MCCC2 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) H2AC14 EP300 H2BC12L CNOT10 CNOT4 EIF4A3 CNOT6 H2AC8 CNOT7 H2AC6 SRPK1 H2AC7 CNOT1 CNOT11 CNOT2 KDM5A CNOT3 KDM5B CNOT8 KDM6B CNOT9 AGO2 CREBBP H4C9 TP53 PABPC1 H2AC20 H2AX H2BC26 EIF4A2 BTG4 EIF4A1 EIF4G1 TUT7 TUT4 H2BC21 H3-3B DUX4 PABPN1L TNKS1BP1 TPRXL H3C8 DUXA TEAD4 DUXB DIS3L2 CNOT6L PRM2 KDM6A PRM1 STPG4 DICER1 METTL23 DPPA4 H2BC17 DPPA3 DPPA2 H2BC12 ZFP36L2 H2BC13 LEUTX H2BC14 HIRA H2BC15 PABPN1 EIF4E H2AJ EIF4B PAIP1 NPM2 H2BC11 KDM4E TPRX1 TET3 AICDA H1-8 TPRX2 ZSCAN4 H3C15 UHRF1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC19 YAP1 H2AB1 H2AZ2 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission GNAT3 ARHGEF9 RPS6KA3 RPS6KA2 NRAS RPS6KA1 GNAI3 MDM2 MYO6 PDPK1 AKAP5 GRIN2A PRKAG2 CAMK1 CAMKK1 CAMKK2 GRIN2B PRKAA1 GNAI1 GNAI2 PRKX PLCB3 PRKACA PLCB1 PLCB2 CALM1 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRNA5 CHRNA4 CHRNA6 RPS6KA6 ACTN2 CASK GABRG3 GABRG2 CHRNA7 CHRNA9 LIN7A GNG10 LIN7C PRKAR2B GRIN2C GRIN2D GRIN3B GNG12 GNAL GNG11 DLG2 GNG13 GRIN3A DLG3 NBEA GNB2 GABRB3 GNB1 GABRB2 GABRB1 DLG4 GRIK5 GNB4 RASGRF1 GNB3 GRIK3 GRIK4 GNB5 GRIK1 GRIK2 NRGN PRKCG GABRR3 GNGT1 GABRR2 GABRR1 LIN7B NPTN GNGT2 NEFL HTR3E HTR3C HTR3D HTR3A HTR3B LRRC7 PPM1E NCALD PPM1F GLRA1 CHRND GLRA2 GLRA3 CHRNG CHRNE KCNJ2 GRIA1 KCNJ3 GRIP1 GABRA2 EPB41L1 GABRQ GRIA2 TSPAN7 KCNJ4 GRIA3 GNG3 GABRA1 GRIA4 GABBR2 NSF KCNJ5 GRIP2 GNG2 KCNJ6 DLG1 GNG5 GABBR1 PICK1 GNG4 KCNJ10 PRKAB1 GNG7 GABRA6 RASGRF2 GABRA5 GNG8 KCNJ12 KCNJ9 GABRA4 KIF17 GABRA3 KCNJ15 KCNJ16 GRIN1 GLRB APBA1 PRKCA AP2A1 SRC CACNG8 CACNG2 CACNG3 PRKAG1 CACNG4 PRKAG3 PRKACG PRKAA2 PRKACB RAC1 NRG1 MAPK1 ADCY9 PRKAR1B MAPK3 PRKAR1A ADCY4 ADCY3 KPNA2 ADCY2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A CAMK2B PRKAB2 CAMK2D GIT1 CAMK2A HRAS CAMK2G PRKCB REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development EP300 SNW1 MAMLD1 INS SLC2A2 KAT2B KAT2A FOXO1 AKT2 AKT3 CREBBP AKT1 ONECUT3 ONECUT1 NOTCH1 NEUROD1 NKX6-1 NKX2-2 MAML2 PDX1 MAML1 RBPJ PAX4 PAX6 HNF1A MAFA RFX6 IAPP INSM1 PTF1A FOXA3 MAML3 NEUROG3 HNF1B FOXA2 FGF10 HNF4G HES1 GCK DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2AC14 H2BC21 H3-3B H2BC12L DNMT3B H3C8 H2AC8 PRIM2 H2AC6 PRIM1 H2AC7 EED POLA1 DNMT3A POLA2 GSDME H2BC17 H2BC12 H2BC13 DNMT1 H2BC14 H2BC15 H2AJ H2BC11 H4C9 H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 H2AC20 H2BC1 EZH2 H2AX RBBP7 H2AC19 H2BC26 H2AB1 H2AZ2 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium YWHAE CEP57 CETN2 DYNLL2 CEP164 CCP110 B9D2 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG RAB8A CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 CCT3 CCT2 TCP1 DYNC2I2 DYNC2I1 IFT70B IFT70A TRAF3IP1 CCT8 DYNLT2B KIF17 CCT5 DYNC2LI1 CCT4 IFT74 IFT56 DYNLT5 TNPO1 DYNLT2 IFT80 IFT20 IFT22 IFT43 IFT81 IFT27 TRIP11 DYNLRB2 DYNLRB1 IFT46 CLUAP1 IFT25 HDAC6 CYS1 LZTFL1 UNC119B ARL6 ARL3 ARL13B FBF1 MCHR1 TTBK2 NPHP1 NPHP3 NPHP4 MARK4 IFT172 RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 IFT52 AHI1 CEP83 CEP89 IFT57 ARF4 DYNC2H1 C2CD3 PKD2 IFT140 RPGRIP1L PKD1 TCTN3 TCTN2 WDR35 TCTN1 KIFAP3 IFT88 CNGA2 BBS9 CNGA4 SMO BBS7 CC2D2A BBS5 BBS4 IQCB1 MKKS EXOC8 EXOC7 KIF24 SSTR3 BBS10 RP2 BBS12 TMEM216 KIF3A EXOC4 KIF3B TTC21B EXOC3 INPP5E EXOC6 EXOC5 KIF3C EXOC2 CNGB1 WDR19 IFT122 EXOC1 ASAP1 TMEM67 PDE6D RHO MKS1 SEPTIN2 GBF1 SCLT1 RAB11A ATAT1 TTC8 CEP162 B9D1 CEP97 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes EP300 ATF4 MAFK NFE2L2 CREBBP NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling NTF3 NTRK2 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPL41 RPL3L RPL23A CUL2 UBE2D1 RPL10 RPL12 RPL11 ELOB RPL14 RPL13 ELOC RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A UBA52 UBE2D2 RCHY1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC RPLP1 PSMA7 RPLP0 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 RPLP2 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 RPL18A PSMB1 RPL36AL PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RPL7A RPL37A RPL36A RPL35A RPL22L1 RBX1 RPL26L1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL9P9 RPL8 RPL6 RPL7 RPL36 RPL35 RPL39L RPL38 RPL37 RPL39 ANKZF1 KLHDC10 RPL21 NPLOC4 VCP TCF25 RPL23 UFD1 RPL22 NEMF LTN1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism LRP2 PRSS1 ABCD4 MTR CBLIF MMUT LDLRAP1 AMN MTRR MMACHC CUBN MMAA MMADHC MMAB LMBRD1 CTRB2 TCN2 CTRB1 TCN1 PRSS3 CD320 ABCC1 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members LTBP4 PSEN2 LTBP2 LTBP3 LTBP1 APH1A APH1B TGFB2 TGFB3 GDF2 SMAD9 INHBB MYC PRKCZ INHBA CCNK SMAD5 CCNT2 DRAP1 BAMBI CCNT1 MYF6 MYCN TCF4 BMPR1B BMPR1A PPP1CC MYF5 ITGB3 TNRC6C MOV10 BMP2 ACVRL1 AGO3 TCF3 BMP10 AGO4 BMPR2 AGO1 ITGB5 AGO2 CHRDL1 TGIF1 ITGB8 PMEPA1 TNRC6A ITGAV TGIF2 TNRC6B ITGB6 TGFB1 AMH MYOG PSENEN HELLS NOG SERPINE1 KLF16 UCHL5 JUNB NEDD4L GREM2 MYOD1 RNF111 TGFBR3 STRAP GIPC1 PPP1R15A USP15 NEDD8 RBL1 ACVR1B FSTL1 FSTL3 PPP1CB ACVR1C ACVR2B ACVR2A INHA COL1A2 ARRB1 E2F4 CDK9 UBE2D1 UBE2M TCF12 USP9X MTMR4 NCOR2 UBA52 NCOR1 CDKN2B SKI UBB UBC RPS27A UBE2D3 PPP1CA EP300 ARHGEF18 MEN1 ARRB2 SKIL RXRA SP1 RARA XPO1 PSEN1 CDK8 NCSTN TFDP1 TFDP2 PARD6A PPM1A SNW1 TIMP2 E2F5 TIMP1 TGFBR1 TGFBR2 RHOA MAPK1 PARP1 MAPK3 STUB1 ITGB1 TRIM33 MMP14 MMP16 CBL FGF2 ATP1B4 SMAD2 SMAD1 SMAD4 FURIN SMAD3 SMURF2 HDAC1 SMURF1 SMAD6 SMAD7 YBX1 WWTR1 CGN F11R FKBP1A PARD3 AMHR2 CCNC CER1 FST ITGA8 FOXH1 ZFYVE16 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins ADPRM NUDT5 NUDT16 NUDT15 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors HCAR2 HCAR3 HCAR1 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 NPM1 MYBL2 HSPD1 TFAP2A CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 UBE2I FBP1 G6PC1 SUMO1 H4C9 CBX3 H2AC20 H2AX PWWP2B ZMYND8 CHD5 CHD4 IKZF1 CHD3 MBD3L2 IKZF2 PHF6 IKZF3 H2BC26 MBD3L1 ADNP2 PWWP2A ZNF687 H2BC21 H3-3B TCF19 ADNP ZNF592 H3C8 ZNF827 CBX1 NR2F2 CDK2AP2 CDK2AP1 ZNF532 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 HDAC2 H3C15 MBD3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 MBD2 H2BC1 GATAD2B GATAD2A RBBP7 PCK1 NR2C2 MTA2 MTA3 H2AC19 H2AB1 H2AZ2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP1A1 CYP2C9 CYP2C19 CYP2C8 CYP2U1 CYP1A2 CYP1B1 CYP4F2 CYP4A11 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression H2AC14 H2BC12L MED1 MYC CCNT1 HSP90AB1 TNRC6C MOV10 AGO3 AGO4 AGO1 GPAM AGO2 GTF2F1 GTF2F2 TNRC6A TNRC6B CREBBP CCND1 CBFB H4C9 RUNX1 H2AC20 H2AX CDK9 HSP90AA1 H3-3B NCOA1 NCOA2 H3C8 NCOA3 FOXA1 SMC3 FKBP4 RAD21 JUND GREB1 STAG1 STAG2 CXCL12 KAT2B SMC1A H2AJ TFF3 TFF1 NR5A2 KANK1 CXXC5 NRIP1 GTF2A1 USF2 GTF2A2 USF1 ZNF217 FOSB EBAG9 H3C15 POLR2A POLR2B POLR2C POLR2D H2BC9 H2BC8 POLR2G H2BC5 POLR2I H2BC3 POLR2J H2BC1 H2AB1 EP300 BCL2 H2AC8 H2AC6 H2AC7 ATF2 ESR1 KAT5 SP1 PGR KDM4B PRMT1 YY1 CARM1 AXIN1 JUN POU2F1 H2BC26 MYB H2BC21 KDM1A PTGES3 TBP FOS CTSD H2BC17 CITED1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 KPNA2 GATA3 TLE3 KCTD6 HDAC1 TGFA POLR2E POLR2F POLR2H DDX5 H2AC19 POLR2K POLR2L H2AZ2 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants KRAS NRAS HRAS BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB HADHA ACADL TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling ANGPT2 ANGPT1 SHC1 PIK3R2 DOK2 GRB14 PIK3CB NRAS TEK PIK3R1 PTPN11 PIK3CA GRB7 SOS1 HRAS ANGPT4 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT10 PABPN1L TNKS1BP1 CNOT4 EIF4A3 CNOT6 CNOT6L CNOT7 CNOT1 DICER1 CNOT11 CNOT2 CNOT3 ZFP36L2 CNOT8 EIF4E EIF4B CNOT9 PAIP1 AGO2 PABPC1 EIF4A2 BTG4 EIF4A1 EIF4G1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex WEE1 CCNB1 YWHAZ CCNA2 CCNA1 YWHAE CDC25C CHEK2 CHEK1 YWHAQ YWHAH YWHAG YWHAB CDK1 SFN GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) INO80 CUL4A ERCC3 POLE4 COPS3 COPS6 COPS5 ERCC4 ERCC2 PIAS3 POLE2 ERCC1 UBE2I POLE3 UBE2N ERCC5 COPS8 CUL4B COPS4 PIAS1 COPS2 SUMO1 SUMO3 LIG1 SUMO2 UBE2V2 POLD1 RFC5 RFC3 RFC4 YY1 RNF111 RFC2 CDK7 CETN2 MNAT1 GPS1 ACTL6A DDB2 RBX1 PCNA PARP1 UBA52 RPA1 RPA2 RPA3 UBB POLK NFRKB POLE UBC RFC1 PARP2 ACTR5 MCRS1 USP45 RAD23A RPS27A LIG3 ACTR8 GTF2H1 CHD1L GTF2H2 RAD23B GTF2H3 DDB1 GTF2H4 INO80C GTF2H5 INO80B RUVBL1 INO80E INO80D XPA CCNH COPS7B COPS7A XPC POLD3 TFPT POLD4 ACTB POLD2 XRCC1 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance APOB CLTC CLTA CES3 AP2A1 PCSK9 AP2B1 LSR LDLRAP1 LIPA AP2A2 NCEH1 NPC1 SOAT1 NPC2 AP2S1 SOAT2 LDLR ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNA1 CHRNA7 CHRNB2 CHRNA9 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRND CHRNA5 CHRNA4 CHRNA6 CHRNG CHRNE SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation IRS2 IRS1 SHC1 MAPK3 INSR GRB10 SOS1 INS MAPK1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria CASP8 BID GZMB NMT1 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling PIAS1 JAK1 PTPN1 PTPN6 SUMO1 JAK2 SOCS1 IFNGR1 IFNGR2 IFNG SOCS3 PTPN11 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism PLPP2 SGPP1 PLPP1 ALDH3B2 ALDH3B1 ACER2 ACER1 SGPL1 ACER3 PLPP3 SGPP2 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs RPL24 EIF4A3 RPL27 CASC3 RPL26 MAGOH RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 LDB1 RPS3A RPL3L RPL23A CUL2 RBM8A UPF3B MAGOHB RNPS1 RPL10 RPL12 RPL11 ELOB RPL14 RPL13 ELOC RPL15 RPL18 RPL17 RPL19 NCBP1 RPL27A NCBP2 RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 PSMD12 RPS13 PSMD11 UBB RPS12 PSMD14 PSMD13 UBC RPLP1 PSMA7 RPLP0 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 RPS4Y2 RPLP2 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 RPL18A PSMB1 RPL36AL PSMD1 RPS4Y1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 RPS26 PSMA2 RPS25 PSMC4 RPS28 PSMC1 RPS27 PSMC2 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 MSI1 HOXA2 ISL1 RPL37A COL4A5 GSPT2 GSPT1 UPF3A LHX3 LHX2 LHX4 RPL36A LHX9 USP33 ROBO1 UPF2 ETF1 RPL35A ZSWIM8 PABPC1 SLIT1 RPL22L1 RPS27L EIF4G1 RPS15A RPS3 RPS2 RBX1 RPL26L1 FAU RPL4 ROBO2 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA SLIT2 RPL35 RPL39L RPL38 RPL37 RPL39 DAG1 RPL21 RPL23 RPL22 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes H2AC14 AGPAT2 H2BC12L SCD PDK4 THRSP MED1 ACSL1 MED4 MED6 MED7 PAXIP1 PEX11A GPAM PPARGC1A PPARGC1B CREBBP H4C9 LPIN1 PNPLA2 CIDEC H2AC20 H2AX ASH2L MED16 MED17 MED12 MED14 MED13 MED10 CD36 H3-3B NCOA1 NCOA2 H3C8 ELOVL5 NCOA6 NCOA3 MED27 SIRT1 MED23 NCOR2 H2AJ MED24 AJUBA NR5A2 NCOR1 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H3C15 TBL1X H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 FABP4 H2AB1 EP300 PHLDA1 H2AC8 H2AC6 H2AC7 ADIPOQ TBL1XR1 KMT2D KMT2C RXRA LPL MED30 MED31 ABL1 CDK8 CDK5 DGAT2 DPY30 PAGR1 H2BC26 H2BC21 WDR5 KDM6A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CEBPA ACSS3 HDAC3 RBBP5 RB1 H2AC19 CCNC MGLL H2AZ2 LIPE DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A PABPC1 EIF1AX EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF2S3 EIF4A2 EIF4A1 RPS15A EIF2S2 EIF4G1 EIF2S1 RPS3 RPS2 RPS15 RPS14 EIF4E FAU EIF4B RPS17 RPS16 RPS19 RPS18 RPS9 RPS7 RPS8 RPS11 RPS5 RPS10 RPS13 RPS6 RPS12 RPSA RPS27A RPS4Y2 RPS4Y1 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing NTHL1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events CALM1 PRKACG PRKACB MAPK1 GNA14 ADCY9 PRKAR1B GNA15 PRKAR1A ADCY4 ADCY3 GNA11 ADCY2 KPNA2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A AHCYL1 PRKCD PRKAR2B PRKCA CAMKK1 CAMKK2 NBEA GNAQ ITPR1 ITPR2 PLA2G4A CAMK2B ITPR3 CAMK2D PRKX PLCB3 CAMK2A PRKACA PLCB4 PRKCG PLCB1 PLCB2 PDE1C CAMK2G GRK2 PDE1B PDE1A SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IP6K2 IPPK IPMK IP6K1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane INPP5F PIK3C3 PIKFYVE PI4K2A MTMR2 MTMR10 MTMR12 MTM1 INPP4A INPP4B MTMR4 FIG4 PI4K2B VAC14 PIK3R4 PIK3C2A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin F2 F8 VWF GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling ERBB2 GRB7 NRG1 NRG2 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation COL16A1 COL12A1 COL23A1 COL4A5 COL17A1 COL13A1 COL1A1 COL1A2 BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 CTSV CTSS MMP20 COLGALT2 ADAMTS2 ITGB4 LOXL3 ADAMTS3 LOXL4 PLOD3 CTSL PLOD2 PLOD1 LOXL1 LOXL2 COL10A1 COLGALT1 COL27A1 P3H2 P3H1 PCOLCE CTSB P3H3 MMP7 COL2A1 LOX COL25A1 COL4A2 COL4A1 MMP3 COL4A4 COL6A2 MMP9 COL4A3 PXDN COL6A1 COL8A2 COL4A6 ADAMTS14 COL6A3 MMP13 COL8A1 COL21A1 ITGA6 COL6A6 COL6A5 PPIB PLEC COL15A1 CD151 PCOLCE2 P4HB COL11A1 LAMA3 COL11A2 SERPINH1 COL19A1 COL28A1 CRTAP COL24A1 COL22A1 COL26A1 COL3A1 LAMB3 COL5A1 P4HA1 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 TLL2 TLL1 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy ACY1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle CASK APBA1 SNAP25 LIN7A LIN7C VAMP2 TSPOAP1 UNC13B RAB3A SYT1 STX1A SYN3 SYN2 CPLX1 SYN1 RIMS1 PPFIA1 LIN7B PPFIA4 SLC18A2 PPFIA3 PPFIA2 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CALM1 PRKACA CAMK4 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex SMARCD1 BCL7C BCL7B SS18L1 DPF1 SS18 DPF2 SMARCA2 DPF3 ACTL6A SMARCA4 SMARCC1 ARID1A ARID1B SMARCB1 SMARCE1 ACTB BCL7A ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) EDEM3 EDEM1 MAN1B1 AMFR SYVN1 DERL2 UBB EDEM2 RNF5 RNF103 RNF139 OS9 UBC TRIM13 UGGT2 UGGT1 RNF185 RPS27A MARCHF6 SEL1L UBA52 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation SMAD2 SMAD4 TCF7 SMAD3 LEF1 EOMES CTNNB1 TBXT TBPL2 GSC NANOG MIXL1 BMP4 TRIM33 POU5F1 FOXH1 SOX2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome ARSB PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling IRS1 PIK3R2 PIK3CB PIK3R1 FRS2 PIK3CA TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B EGF ERBB2 EGFR PPP2R1A MKRN1 WWP2 UBA52 AKT2 AKT3 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 BAD PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ATF2 INSR FOXO6 FOXO4 FOXO3 RRAGA FOXO1 RRAGC RRAGB PDGFRA RRAGD FGF6 AKT1 MAPKAP1 LCK SRC CDKN1A NTRK2 BDNF RPTOR THEM4 SGK1 MAPK1 MAPK3 RICTOR FGF1 FGF4 STUB1 FGF16 FGF9 FGF18 FGF20 PIK3CD FGF23 PIK3CG LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 TGFA USP7 RAC2 CASP9 SLC38A9 RHOG IRAK1 VAV1 FYN RHEB PIP5K1A MDM2 GSK3A PIP5K1B PIP5K1C IER3 MYD88 FLT3LG PDGFB CD19 PRR5 EGR1 PDPK1 SNAI1 CD28 IRAK4 SNAI2 STRN GAB2 FLT3 PHLPP2 TRAF6 PHLPP1 MLST8 IL33 CD86 KLB CD80 TRIM27 ATN1 SALL4 USP13 MAF1 TNKS PDGFRB TNKS2 RNF146 FGF19 FRK FGFR4 AKT1S1 OTUD3 IL1RL1 TRAT1 RPS6KB2 PIK3AP1 PTPN11 EPGN EZH2 PIK3R3 MTOR PIK3R6 PML PIK3R5 MBD3 SUZ12 IRS2 GATAD2B GATAD2A ESR1 CHUK PPARG HGF TP53 REST BMI1 GAB1 MET PTEN AREG RING1 HDAC5 RNF2 CSNK2A1 HDAC7 FGF7 GSK3B CSNK2A2 FGF22 FGF3 CBX8 FGF10 CHD4 PPP2R5B PHC2 CHD3 PPP2R5A CBX6 PPP2R5D PHC1 PPP2R5C CSNK2B JUN PPP2CA PPP2CB CBX4 CBX2 PPP2R1B PHC3 PPP2R5E TSC2 CDKN1B KDM1A RAC1 NRG1 EED INS NRG2 EREG BTC XIAP NRG3 NRG4 HBEGF KIT NTRK3 FGF2 HDAC2 HDAC3 MECOM PIP4K2A HDAC1 TRIB3 ESR2 PIP4K2B MTA1 NR4A1 PIP4K2C RBBP4 NR2E1 RCOR1 NTF3 NEDD4 PREX2 RBBP7 MTA2 MTA3 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis RIPK3 MLKL GSDME CASP1 IRF1 IRF2 TP63 HMGB1 GZMB PELI1 CHMP4C CHMP4B CHMP4A TP53 CYCS CASP5 IL18 CASP4 IL1A IL1B SDCBP OGT ELANE CHMP2B CHMP2A BAX UBE2L3 HSP90AA1 FLOT2 CDC37 CASP3 TRADD PDCD6IP TNFRSF10B FASLG TNFRSF10A TRAF2 CASP8 XIAP TNFSF10 FAS RIPK1 CHMP3 FADD STUB1 UBA52 CHMP6 CHMP7 BIRC2 BIRC3 UBB UBC PRKN ITCH RPS27A GSDMD FLOT1 BAK1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events ARHGEF19 VAV2 RHOB ARHGEF18 ARHGEF9 ARHGEF3 TIAM2 ARHGEF4 ARHGEF1 NGEF ARHGEF2 ARHGEF7 ARHGEF5 ABR ARHGEF6 GNA13 GNG3 PLXNB1 GNG2 GNG5 GNG4 GNG7 RASGRF2 GNG8 PLEKHG2 SOS2 ADRA1D ROCK2 ADRA1B ADRA1A TBXA2R GNA12 TIAM1 ARHGEF33 FGD1 ARHGEF35 FGD2 ARHGEF37 ROCK1 ARHGEF38 FGD3 FGD4 ARHGEF40 PLEKHG5 MCF2 RHOA ARHGEF26 BTK SOS1 KALRN ECT2 ARHGEF39 GNG10 NET1 GNG12 GNG11 GNG13 TRIO GNB2 AKAP13 GNB1 ITSN1 GNB4 ARHGEF10L GNB3 GNB5 MCF2L PREX1 OBSCN ARHGEF11 VAV3 GNGT1 ARHGEF10 ARHGEF12 ARHGEF15 GNGT2 RHOC ARHGEF17 ARHGEF16 VAV1 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease ERCC3 ELK1 ERCC2 MAP2K4 MAPK9 MAPK8 MAP2K7 CLU TLR1 S100A9 S100A8 TLR2 LTF HEY1 HEY2 CD4 PSMD12 PSMD11 NOTCH1 PSMD14 PSMD13 RBPJ DLL1 PSMA7 PSMB6 PSMD8 LFNG PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 MCCC2 PC BTD PCCA HLCS MCCC1 PCCB FOXO6 FOXO4 FOXO3 ACACA SLC5A7 FOXO1 YWHAB ELAVL1 XPO1 AKT1 NUP214 YWHAZ XRN1 PABPC1 HSPA8 ITGA4 MAPK14 HSPA1A EIF4G1 PRKACG PRKACB RBX1 ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A CSNK1A1 ITCH GNAS SLC35A1 TGFA B4GAT1 DAG1 LARGE1 POMGNT1 YES1 SPRED3 SPRED2 SPRED1 HRAS CUL3 NRAS NF1 IHH CCND3 C3 CCND2 CCNK CCNT2 NUP107 CCNT1 NUP188 GTF2B RCC1 BANF1 KPNA1 SUPT16H LIG1 NUP210 LIG4 GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 POM121 TSG101 SUPT4H1 JUNB NEDD4L AAAS GTF2E1 GTF2E2 NUP160 POM121C NUP85 TPR NUP88 XRCC6 XRCC4 NUP155 XRCC5 VTA1 HMGA1 ELOA2 NUP153 SUPT5H CDK9 CHMP2B CHMP2A NMT1 TAF4B NMT2 FEN1 ELL TAF7L NUP62 ELOA NELFB ELOB NELFCD NELFA ELOC CCR5 NELFE TAL1 NDC1 SEC13 PDCD6IP NCBP1 NUP133 NCBP2 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 TAF1L POLR2A POLR2B NUP42 POLR2C POLR2D MVB12B MVB12A POLR2G NUP43 POLR2I TAF9B ITGA2B POLR2J RAE1 RANBP2 RANBP1 RNGTT TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 UBAP1 NRBP1 TAF7 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 RAN TAF2 NUP37 TAF1 IDUA HEXB NCAN HEXA BGN VCAN HYAL1 GLB1 IDS CSPG5 GUSB ARSB CHUK UBA7 HSPA5 EIF2AK3 UBE2L6 ISG15 CDK6 IFIH1 HERC5 IKBKB TRIM25 ARIH1 IKBKG RIGI CLTC CLTA AP2A1 AP2B1 AP2A2 AP2S1 SH3GL2 AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB RAD51 APC PPP2R1B PPP2R5E CDC37 ERBIN PHB1 TWIST1 PARP1 ITGB1 GP1BA CAMK4 FGF2 SMAD2 SMAD4 SMAD3 ESR2 NR4A1 JAG1 YBX1 CAMK2B CAMK2D CAMK2A THBS1 HES1 CAMK2G ALK IRS1 PIK3R2 PIK3CB PIK3R1 MYC JAK3 FRS2 PIK3CA PROS1 PTPN6 ITGB3 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 FGB FGA GP1BB TGFB1 FGG CCND1 F2 KRAS F5 RUNX1 F8 F9 SERPING1 F10 F12 F11 GP5 GP9 PROC EIF2AK2 CEBPB PRKX ANAPC15 SEMA5A ANAPC16 POMT2 UBE2D1 SPON2 ANAPC10 SEMA5B RELA SPON1 THSD7B ANAPC11 POMT1 FZR1 CDC23 ADAMTSL1 CDC26 ADAMTS2 C1GALT1C1 CDC27 ADAMTS3 ADAMTSL5 TCF7L2 ADAMTSL4 ANAPC7 UBE2C ADAMTSL3 ADAMTSL2 CDKN2A MUC12 UBE2E1 MUC15 NFKB1 THSD7A IL6 UBE2S ADAMTS6 CDC16 ADAMTS7 ANAPC4 SBSPON ANAPC5 MUCL1 MUC3A ANAPC1 MUC5AC ANAPC2 MUC3B PATJ ADAMTS20 ZDHHC5 B3GLCT ZDHHC8 CFP ZDHHC2 THBS2 ZDHHC3 ADAMTS12 RPS15 THSD1 RPS14 GJA1 THSD4 ADAMTS10 RPS17 ADAMTS15 RPS16 TBK1 ADAMTS14 RPS19 MUC1 SNRPD2 MUC2 ADAMTS19 RPS18 ADAMTS17 SNRPD1 AKT2 MUC7 AKT3 MUC4 SNRPD3 MUC6 MUC16 RPS11 GALNT3 B2M MUC17 GOLGA7 MUC19 RPS10 RPS13 C1GALT1 VPS39 SSPOP MUC5B RPS12 MUC20 VPS18 MUC21 HLA-H IPO5 ST6GAL1 HLA-B GRSF1 DNAJC3 HLA-C MOGS HLA-A BRCA2 ATG14 RAD51AP1 HLA-F HLA-G HLA-E ACE2 RPS4Y2 SDC4 RPN2 SAR1B XRCC2 SDC2 SDC3 PALB2 RPN1 SLC17A8 PIK3R4 RPS4Y1 IFIT1 LARP1 IFIT3 VPS11 IFIT2 VPS36 ST3GAL4 SFN SNF8 VPS25 ST3GAL1 ST3GAL2 VPS16 ST3GAL3 SRPK2 EDEM2 PARP16 PARP14 SRPK1 PARP10 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 ATP1B3 RPS23 IFNA5 ATP1B2 NRP1 ATP1B1 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 MAGT1 IFNA8 MAP1LC3B RAF1 TRIM4 HAVCR1 IKBKE JAK1 TOMM70 PARP6 PARP4 PRMT1 RIPK2 SFTPD ANO8 ANO9 ANO6 TYK2 ANO7 ZDHHC11 ANO4 PARP9 ANO5 IL17RC ANO2 PARP8 ANO3 IL17RA ANO1 SIKE1 CANX TLR8 TLR7 FXYD4 ZDHHC20 RPS27L FXYD3 TMPRSS2 RNF135 FXYD2 RPS15A GPC1 FXYD1 MGAT5 FXYD7 RPS3 FXYD6 GPC3 ANO10 GPC2 GPC5 MGAT1 RPS2 GPC4 MGAT2 GPC6 STAT1 IFNB1 STAT2 TJP1 NLRP12 STING1 ZDHHC9 IL17F FAU AGRN CRB3 ATP1A4 IL17A ATP1A3 TUSC3 GEMIN2 ATP1A2 KPNA2 MAP3K7 ATP1A1 RPS9 IFNA14 RPS7 RPS8 IFNA16 RPS5 VPS33A IFNA17 RPS6 VPS33B RPSA ZCRB1 TUFM TMEM258 GEMIN4 SNRPG GEMIN5 GEMIN6 CLCN6 SNRPE UBE2V1 GEMIN7 MASP1 SNRPF GEMIN8 ISCU IFNA10 IFNAR1 SNRPB FKBP1A VCP DDX5 IGHG3 FUT8 TKFC IGHG4 IRAK1 CYSLTR1 IRAK2 IGHG1 CYSLTR2 MAN2A1 G3BP1 IGHG2 SMN2 GNAT3 G3BP2 GNAZ NLRP3 CD3G IFNA21 FCGR3A SYK UVRAG OST4 FGR CAV1 HCK ADORA2B MAVS GNAI3 OSTC FYN STT3A UBE2N FCGR1A FCGR2A TAB3 OPN1SW TAB2 TAB1 STT3B PALS1 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH RPS4X MYD88 YWHAQ NFKBIB MBL2 HMGB1 YWHAH PDPK1 RPS3A IRAK4 DDOST TLR9 IRF3 DAD1 TRAF3 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB VHL SEC24B SEC24A CNBP GALNT1 PTPN11 EPGN MGAT4C MGAT4A ARRB1 MGAT4B VPS41 CLINT1 AP1G1 VPS45 SEC24D AP1S2 SEC24C AP1S1 AP1S3 AP1B1 AP3B1 CALM1 RAB5C AP1M2 AP1M1 GOLGB1 SFTPB SFTA3 SFTPA2 SFTPC CCNE2 CCNE1 CSF2RB SFTPA1 CSF2RA GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 IRS2 GNB4 GNB3 GNB5 GNGT1 WNT5A GNGT2 FZD5 FZD4 FZD7 FZD6 FZD8 ARRB2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 UGT1A4 GALE SI LCT B4GALT1 MAML2 MAML1 TRIP11 TFDP1 TFDP2 MAML3 NOTCH2 NOTCH3 STX1B NOTCH4 SEL1L E2F1 E2F3 JUN KEAP1 SNW1 MAMLD1 SLC24A5 CDKN1B RAC1 NRG1 NRG2 EREG BTC SFPQ NRG3 NRG4 ELMO1 RNF213 ELMO2 DOCK1 ATG7 CRK HBEGF CBL CDK4 CDK2 FASN EIF4A3 CDC40 SRRM1 LMO7 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 CUL5 SRSF9 UBA6 UBA5 UBR4 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 ABCD1 UBA3 UBA1 TRADD LY96 FASLG TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD TLR4 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 GOLGA2 RIPK3 V1-20 CDC25A IGKV2D-40 IGHV3-11 CDC25B IGHV3-13 PRIM2 IGKV1D-16 PRIM1 MLKL IGLV7-43 POLA1 IGKV1D-12 POLA2 NFKBIA IGLV1-51 GSDME IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 PDGFRA V5-1 V1-5 PTBP1 FGF6 V1-3 IGKV3D-20 V5-6 HNRNPH1 IGLV3-19 ESRP1 HNRNPA1 IGKV2-30 IGHV2-70 HNRNPM IGHV2-5 IGLV3-1 CTNND1 IGHV3-48 IGLV3-25 CBLL1 EPS15 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 V4-6 MYH2 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 NTRK2 BDNF CDK5R1 GCKR GCK TGFBR1 TGFBR2 MAP2K1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 SLC34A3 SLC34A2 SLC34A1 P4HB GSDMD CASP9 ATRX OPN1MW SQSTM1 FLT3 TRIM27 TNKS TNKS2 MED19 MED15 MED18 C3AR1 IL18 IL1A MED11 IL1B P2RX4 ATIC CHST6 GNE MED26 EIF4A2 MED29 EIF4A1 MED28 MED22 MED25 CYP21A2 MED21 CHST3 PABPN1 EIF4E ABCB11 TPST2 TPST1 PGK1 G6PC1 G6PC3 SP1 OGN TBXAS1 SNAP25 PTEN PGM1 NAGS OMD TALDO1 EXOC1 GBF1 BRIP1 NEU1 NTF3 NPLOC4 UFD1 MED13L EXT1 PSEN2 EXT2 APH1A APH1B ACY1 KHK PSENEN GAA APRT AHCY GNAI1 GNAI2 CYP17A1 CBX1 SLC2A9 FKBP4 KANK1 SHC1 GALK1 CYP26B1 CYP26C1 GALT SLC3A2 GZMB IFNGR1 IFNGR2 GALNS GALM NTHL1 GNS HMOX1 TCN2 PAH PPIB P4HA1 P4HA2 P4HA3 SYT1 PAPSS2 PAPSS1 SLC17A5 GSS SYVN1 DERL2 RNF5 OS9 RNF185 TPMT RPL10L RPL10A PPP1CC FLT3LG PDGFB CD19 CD28 STRN GAB2 KERA CD86 KLB SLC26A2 CD80 PDGFRB FGF19 FGFR4 AKT1S1 TRAT1 RPS6KB2 PIK3AP1 CASP4 RAB5A FGFR1OP2 ZC3HAV1 RDH12 JAG2 FN1 PPFIBP1 HYOU1 PRKG2 SHH DUSP8 DUSP9 ATL2 NEURL1B CRBN UGT1A1 NUDT21 HHAT FNTA FNTB MSH6 MSH3 APOA1 LY6E RPL13A FUS NACA ISY1 RLBP1 KIAA1549 BCAS2 C1S E2F2 HNRNPA0 HNRNPA3 GPKOW CDC5L TTR PDCD1 C4A KDR TRIM24 ALG8 ALG9 ALG6 ALG2 ALG3 ALG1 DHX9 MC2R BST2 BCKDK CD209 GRB2 CALR SUGP1 IGHM IL22 SLC67A1 AGTRAP CNKSR2 CNKSR1 IGHD MTRR PEX19 AGGF1 PEBP1 IGF1R IL6R DHDDS PNP DNAJB11 RPL18A PPIE RPL36AL PPIH PPIG SYT2 TENT4A MYO18A SUN2 ETV6 WDCP SV2C SV2B SV2A CD9 HNRNPU SLC4A1 CYP2U1 HNRNPR SLC4A4 TFG MAP1B CTBP2 CTBP1 SLC22A5 ICOS SLC35D1 BTF3 HNRNPL HNRNPK HNRNPD TXN CDKN1C WDR48 WDR33 APBB1IP GAS6 EPCAM IL10RA PHF5A AUP1 IPO7 PAPOLA CD320 TXNL4A GBE1 SLC39A4 SNRPN SLCO2A1 RAB5B CYP7B1 FAM114A2 MCL1 SLC26A4 SLC26A3 AVPR2 PLRG1 TIRAP SKIC8 DNAJC8 CEBPD FIP1L1 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 NPIPB3 PPIL3 NT5E PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 NEIL3 TLN1 NEIL1 CSTF3 CSTF2 CD79B FXR1 CD79A CSTF1 HIP1 SLC22A12 PTGES3 CHMP1A HNRNPH2 TLR6 TLR5 C1QA LMNA EMC4 SPCS3 SPCS2 SPCS1 CWC25 CWC27 CWC22 ALG14 ALG13 COMT ALG12 ALG11 PRPF6 PRPF8 CPSF4 CPSF6 CPSF1 RPL9P9 CPSF3 CPSF2 CWC15 FGFR3 FGFR2 FGFR1 SLC40A1 CGAS HEPH BLNK RBM5 HGSNAT OAS2 RFT1 GBP2 GBP1 HES5 IDH1 GBP4 ARAF C4BPA C4BPB CLDN1 MPRIP GBP6 SND1 EML4 ABCB6 DHH SLC5A1 SLC5A2 GRPEL1 ABCA3 ABCA4 PMM2 ERLIN1 ERLIN2 CP NAPEPLD NOX4 PQBP1 VAMP1 TLR10 OPLAH RNASEK SRRT SLC16A1 HK1 HEYL PIM1 CYP2R1 KPNA7 DBT KPNA4 KPNA5 KPNA3 S100A1 SNRNP200 PORCN QKI ZC3HC1 GGCX FOXM1 CTNNBL1 KSR1 SIGMAR1 KSR2 PPM1B BIRC6 PRCC CHSY1 LRP5 LRP6 SLC12A3 SLC12A1 MERTK LUM KDELR1 PRF1 GCC2 CCAR1 SLC12A6 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 LRAT SEC31A PAF1 CALM3 CALM2 RETREG1 DHX15 DHX16 CD33 HBA2 RBP4 DERL3 DERL1 MIB1 RBP1 DPAGT1 SH3GL3 MPI SH3GL1 ZBP1 WBP11 CD8B HNRNPUL1 VCL RTN3 DOLK DDX3X DDX46 ABCB4 DDX42 LRRFIP1 RBM17 IQGAP1 DYNLT1 BUD31 RBM22 BCL2A1 DCTN1 DDX23 CSTF2T RRBP1 ERLEC1 SLC5A5 SMNDC1 U2SURP FAM131B ABCA12 CLP1 DKK1 DKK2 DKK4 BIN2 TYRO3 ABCA1 BRAP SLC6A5 OGG1 SLC6A2 SLC6A3 OPN1LW MRC1 SLC2A10 MRAS SF3B4 SF3B5 ARF1 SF3B2 RPLP1 SF3B3 RPLP0 SF3B6 BRD4 SF3A3 SF3A1 SF3A2 XAB2 RHAG RPLP2 HSPA1B CLEC4M CLEC5A RNF43 NCL VTN BAG4 BAG2 STRA6 MPDU1 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 DUSP16 DUSP10 CX3CR1 SLC24A1 SLC24A4 DLD UNC93B1 VAMP2 PUF60 SNRPB2 PTPN12 GOLGA4 AQR SLC11A2 C4B_2 NUS1 BCL11A NMI SH3KBP1 PRPF19 ZMYM2 PCF11 AVPR1B KREMEN1 AVPR1A KREMEN2 PACS1 RDH5 MAPRE3 AVP SLC20A2 CUX1 SHOC2 AXL HDLBP EFTUD2 PDIA3 ABCG8 ABCG5 CD300A DPM1 DPM2 DPM3 MARK3 RPL22L1 DNAJC10 ELAVL2 UPK1A ABCC6 ABCC9 DLL4 S1PR1 NHERF4 NEURL1 EPM2A KPNB1 CYP19A1 ACAT1 SLCO1B1 SLCO1B3 SRD5A3 B3GALT6 PIK3CD PIK3CG SLC25A15 SLC25A4 PPM1K MMAA MMAB RPL23A AHCYL1 ENTPD1 ENTPD5 PPP1R3C STX1A MMADHC PIK3R3 PIK3R6 PIK3R5 CTSA RPL27A WASL PPP1CA GGT1 MAT1A DPEP2 DPEP1 CYP11A1 GGT5 GCLC CYP11B2 CYP11B1 GCLM MTR BCKDHA BCKDHB LMBRD1 RPIA CYP24A1 RPL26L1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 ENO1 RPL8 RPL6 RPL7 FDXR RPL36 RPL35 CYP1B1 RPL38 MMUT RPL37 RPL39 CUBN RPL21 RPL23 RPL22 MED8 MED9 FDX1 FDX2 ACOT2 RPL24 NHLRC1 RPL27 HPRT1 RPL26 RPL29 RPL28 PLCG2 CHST14 CDK19 RPL41 RPL3L ADA IVD RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 FMO3 FMOD NAGLU GYG2 GYG1 ITPR1 ITPR2 ITPR3 CYP4F22 RPL7A SLC37A4 AMN RPL37A RPL36A KCNJ11 TXNRD1 RPL35A ASS1 IMPDH1 IMPDH2 MMACHC CYP27A1 MAOA CYP27B1 SCAP ASL RPL39L CBLIF GYS2 GYS1 AUH ALDOB NMRAL1 ABCD4 SLC2A1 SLC2A2 SGSH HIBCH ABCC2 ABCC8 DCXR B4GALT7 PRELP B3GAT3 POMC APP MEFV NFKB2 P2RX7 PYCARD PSTPIP1 CASP1 TXNIP SUGT1 SKP2 CARS1 RAP1B HGF GAB1 MET AREG NFE2L2 EEF1G EEF1A1 EEF2 FGF7 FGF22 FGF3 FGF10 WNT3A TSC2 KDM1A KIF5B KLC1 PHF21A RCOR1 HBB HMG20B JAK2 RAD51B RAD51C DOCK2 CDC42 GUCY2C NOS2 CORO1A HGS ATP6V1H RAB7A LMNB1 PAK2 IL10 MSN SOD2 HNRNPF HNRNPA2B1 SNRPA1 SLC1A1 SLC1A3 SLC3A1 SLC6A20 SLC6A19 SLC36A2 SLC6A14 SLC7A7 SLC7A9 DUSP6 DUSP7 CD163 PLK2 RHBDF2 MYH9 KAT5 DAXX HUS1 DNA2 RHNO1 MAPKAP1 PRDX2 PRDX1 ATRIP BARD1 RAD17 ATM ATR CDKN1A BRCA1 RPTOR RMI2 RMI1 TOP3A RAD51D WRN PMS2 RICTOR NPM1 RPA1 RPA2 MLH1 RPA3 RAD1 MRE11 NBN CDC25C MSH2 BLM MDM2 RAD9B RAD9A PRR5 EXO1 MLST8 TOPBP1 RFC5 RFC3 RFC4 RFC2 RBBP8 MTOR PML RAD50 TLR3 HDAC10 H2AC17 H2AC12 H2AC25 H2AC21 ARID4A H2AC1 BRMS1 HDAC4 UBE2I NR3C1 ESR1 SUMO1 H2BC18 KDM7A HDAC8 ECHS1 PPIA CPS1 ARG1 TP53 REST OTC SLC35A2 SLC35A3 SLC33A1 SLC35C1 SLC25A5 CSNK2A1 SLC29A3 SLC27A4 CSNK2A2 SLC25A6 ROCK1 CSNK2B MUC13 RBMX KIT NTRK3 SLC9A6 SLC9A9 ADAMTS13 VWF CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 BCR DYNC1LI1 DYNC1LI2 AGK NCKAP1L HNRNPC NOX1 ARPC1B ARPC1A EGF ERBB2 PLCG1 EGFR YWHAE DYNLL2 PPP1CB PPP2R1A NEK2 BTRC PRKACA YWHAG SKP1 HSP90AA1 TUBB DYNLL1 ABI2 AKAP9 TAOK1 UBA52 ABI1 DYNC1I2 CUL1 CCNB1 UBB PRKAR2B UBC RPS27A TPM4 TPM3 DYNC1H1 CLIP1 CEP43 BCL2L11 BAD STAT3 DVL1 DVL2 DVL3 BCL2L1 ARPC4 ARPC5 CAPNS1 CAPNS2 ARPC2 ARPC3 CDH1 NOXA1 BSG CAPN2 MAP3K11 CAPN1 CAST BRK1 ADAM10 HSPG2 BCAN ADAM17 NCK1 ACTR3 ACTR2 PSEN1 LCK ADAMTS16 NCSTN ADAMTS18 SRC ROCK2 CSK ADAMTS4 ADAMTS5 WASF1 WASF2 WASF3 CTSL ADAMTS1 BAIAP2 CTSG ADAMTS8 ADAMTS9 BTK MMP9 DCN CFTR SPTBN1 FURIN STAM PTK2 ACAN C1QBP RAC2 KLKB1 RB1 CCNH VAV3 H2AC19 RHOG CCNC ACTB VAV1 VAV2 H2AC14 TRIM28 H2BC12L MED1 MED4 MED6 MED7 WAS NOXO1 TRAK1 CREBBP DYNC1I1 H4C9 BCAP31 MYO9B H2AC20 EZH2 H2AX ASH2L MED16 ACTG1 MED17 MED12 MED14 MED13 MED10 CD36 H3-3B H3C8 CYBA STAM2 MED27 MED23 NCOR2 KAT2B KAT2A H2AJ MED24 NCKIPSD NCOR1 MED20 CPSF7 GPS2 H3C15 TBL1X SF3B1 MBD3 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GATAD2B GATAD2A H2AB1 ARID4B EP300 H2AC8 ZAP70 H2AC6 H2AC7 SAP30 TBL1XR1 KMT2D DNMT1 MED30 MED31 ABL1 VIM SUDS3 HDAC11 CDK8 CDK7 CDK5 IRF4 HDAC5 HDAC9 MNAT1 HDAC6 HDAC7 GSK3B STAT5A PSIP1 DPY30 STAT5B CHD4 CHD3 H2BC26 SIN3A H2BC21 DNMT3B WDR5 GFPT1 TBP EED DNMT3A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 MIB2 H2BC11 CDC73 HDAC2 HDAC3 HDAC1 LEO1 MTA1 RBBP4 RBBP5 SAP30L POLR2E POLR2F SAP18 POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L H2AZ2 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery SMN2 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A DDX20 RPS27L RPS15A RPS3 RPS2 RPS15 RPS14 FAU RPS17 RPS16 GEMIN2 RPS19 SNRPD2 RPS18 SNRPD1 RPS9 RPS7 SNRPD3 RPS8 RPS11 RPS5 RPS10 RPS13 RPS6 RPS12 RPSA GEMIN4 SNRPG GEMIN5 GEMIN6 RPS27A SNRPE GEMIN7 SNRPF GEMIN8 RPS4Y2 SNRPB RPS4Y1 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 CDIPT PITPNM2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids ACAA1 ACOT8 DECR2 HSD17B4 EHHADH ACOT4 SLC27A2 ABCD1 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease STAT3 ETV6 PIK3R2 PIK3CB NRAS PIK3R1 GOLGA4 STAT1 FIP1L1 PIK3CA WDR48 KANK1 SOS1 PDGFRA STRN HRAS BIN2 KDR PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PPIA PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 GAB1 PIK3R1 PTPN11 FRS2 PIK3CA FGF1 FGF4 FGF22 FGF3 FGF9 FGF10 FGF20 FGF23 FGF6 FGF2 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor IRS1 PIK3R2 PIK3CB NRAS PIK3R1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0E1 ATP6V1G2 FRS2 PIK3CA FLT3LG INSR GRB10 PDPK1 TLR9 ATP6V0D1 FLT3 GAB2 FGF6 ATP6V0D2 ATP6V1A PIK3C3 KLB GAB1 FGF19 ATP6V0A2 FGFR4 ATP6V0A4 ATP6V1D ATP6V1C1 PTPN11 ATP6V1F ATP6V1C2 FGF7 ATP6V0A1 PDE3B IDE FGF22 FGF3 PTPRF FGF10 ATP6V1H TCIRG1 THEM4 INS CTSD ATP6V0B MAPK1 ATP6V1B2 MAPK3 FGF1 ATP6V0C ATP6V1B1 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 AKT2 FGF2 SHC1 PTPN1 ATP6V0E2 ATP6V1G3 TRIB3 IRS2 PIK3R4 HRAS ATP6AP1 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis ABO FUT2 FUT1 CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly CASP4 CALM1 CALM3 CALM2 SERPINB1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis NCOR2 NCOA1 RXRA NR1H3 NCOR1 FABP6 RXRB NR1H2 UGT1A3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs CPSF7 CSTF2 CSTF1 NUDT21 NCBP1 NCBP2 FIP1L1 SYMPK CSTF2T PABPN1 PCF11 WDR33 CLP1 CPSF4 CPSF1 CPSF3 CPSF2 PAPOLA CSTF3 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins CYP26A1 CYP24A1 CYP26B1 CYP27B1 CYP2R1 CYP26C1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation PRKCA PRKCG STXBP3 STX4 PRKCB SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 CD274 CUL3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CCND1 PSMD12 PSMD11 UBB CDK4 PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 CSNK2A1 PSMB5 PSMD7 PSMB2 PSMB3 CSNK2A2 PSMD2 PSMD3 PSMB1 PSMD1 YWHAG SPOP CSNK2B ADRM1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins RAP1B PTK2 BCAR1 VWF ITGA2B RAP1A SRC ITGB3 APBB1IP CRK FGB FGA TLN1 FGG FN1 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS SFTPC ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 AVP AVPR2 PRKACA RAB11FIP2 MYO5B PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNG10 PRKAR2B GNG12 GNAS AQP12A GNG11 AQP10 GNG13 AQP8 AQP9 RAB11A GNB2 AQP6 AQP7 GNB1 AQP4 AQP5 AQP2 GNB4 AQP3 GNB3 AQP1 MIP GNB5 AQP11 GNGT1 GNGT2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A3 SLC12A5 SLC12A1 SLC12A7 SLC12A6 SLC12A2 SLC12A4 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD POMC MC2R ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus PSEN2 DTX1 DTX2 DTX4 APH1A DNER NEURL1B APH1B DLK1 CNTN1 ARRB2 NUMB MIB2 UBA52 ADAM10 PSENEN ADAM17 UBB NOTCH1 PSEN1 UBC ITCH DLL1 RPS27A NCSTN JAG1 DLL4 ARRB1 NEURL1 MIB1 JAG2 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 OXA1L MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 TUFM MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 MRPL50 MRPS9 KGD4 MRPL51 AURKAIP1 DAP3 MRPS35 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 HSPB1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PABPC1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 HSPA8 PSMD1 ADRM1 HSPA1A EIF4G1 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 RFC5 RFC3 UBB RFC4 RFC2 UBC RFC1 RPS27A PCNA UBA52 RPA1 RPA2 REV1 MAD2L2 RPA3 REV3L SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors COLEC12 MSR1 FTL COLEC11 SCARA5 APOB HSP90B1 MARCO SCGB3A2 COL3A1 CALR APOA1 COL4A2 COL1A1 COL4A1 MASP1 COL1A2 FTH1 APOE DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System PRL EGF AREG FGF10 TGFA AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol AKT1 TSC2 CDKN1B AKT1S1 GSK3A MDM2 GSK3B CDKN1A CHUK CASP9 MKRN1 AKT2 AKT3 BAD RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib CDC37 ERBIN ERBB2 HSP90AA1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection HMGA1 BANF1 PSIP1 PPIA SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 SPINT1 MST1 HPN SPINT2 MST1R COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly LETM1 MT-CYB BCS1L UQCRH LYRM4 TTC19 LYRM7 UQCC3 UQCC2 UQCC1 UQCRHL UQCRFS1 UQCC6 UQCC5 HSCB UQCR11 CYC1 UQCR10 UQCRQ HSPA9 UQCRC1 FXN UQCRB UQCRC2 SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer SHC1 GAB1 CDC37 ERBIN EGF NRAS PIK3R1 ERBB2 PLCG1 EGFR NRG1 PTPN12 NRG2 EREG BTC PIK3CA NRG3 NRG4 HBEGF SOS1 HRAS HSP90AA1 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria GSDMD DIABLO CYCS BAK1 BAX GSDME INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade F2 GPC1 F3 F5 F7 GPC3 F8 GPC2 F9 GPC5 VWF SERPINC1 GPC4 F10 GPC6 SDC1 PROS1 SDC4 AGRN SDC2 SDC3 HSPG2 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis CASP3 GSDME CASP1 IRF1 IRF2 TP63 CHMP3 HMGB1 GZMB CHMP6 CHMP7 CHMP4C CHMP4B CHMP4A TP53 CYCS CASP5 IL18 CASP4 IL1A IL1B ELANE GSDMD CHMP2B BAK1 CHMP2A BAX REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V1B2 ATP6V0C ATP6V1H ATP6V1E1 ATP6V0B ATP6V0D1 ATP6V1G1 ASAH1 ATP6V0E1 ATP6V1A ATP6V1C1 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins UBE2N RRAGA UBE2V2 CTR9 SKIC8 RTF1 UBE2B RNF152 SHPRH PEX2 RNF40 RNF144A SELENOS UBE2A PAF1 WAC PRKDC TMEM129 HLTF PEX10 PEX12 UBE2D1 PEX13 PEX14 DERL1 RNF181 RAD18 UBE2L3 RNF20 UBE2E1 H2BC17 PCNA H2BC12 H2BC13 H2BC14 H2BC15 UBE2J2 UBA52 UBE2D2 H2BC11 CDC73 UBB LEO1 UBC H2BC9 H2BC8 H2BC5 H2BC3 HLA-A RPS27A UBE2D3 H2BC1 BCL10 VCP METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion INMT EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L RPL37A RPL23A GSPT2 GSPT1 RPL36A ETF1 RPL35A RPL22L1 APEH RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A RPL37 TRMT112 RPL39 HEMK2 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GSS GGT1 GCLC OPLAH GCLM GGT3P GGCT CNDP2 GGT5 GGT7 CHAC2 GGT6 CHAC1 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria DCXR INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling STAT3 JAK1 STAT5A STAT5B IL2RG STAT1 IL9 IL9R JAK3 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation EPCAM UPK1A FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation FGF1 FGF9 FGF18 FGF20 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism CSF2RB SFTPA1 CSF2RA SFTPD SFTPB ABCA3 SLC34A2 SFTA3 SFTPA2 SFTPC MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression SNCB MTF1 CSRP1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome RB1 ZCRB1 DDX5 VHL ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility MEMO1 EGF ERBB2 EGFR NRG1 NRG2 DIAPH1 RHOA EREG BTC NRG3 NRG4 HBEGF SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer SHC1 GAB1 CDC37 EGF NRAS PIK3R1 PLCG1 EGFR PIK3CA SOS1 HRAS CBL HSP90AA1 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) SV2C SV2B SV2A VAMP1 VAMP2 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA PQBP1 NXT1 EIF4A3 CASC3 GLE1 MAGOH SRRT THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 SRRM1 THOC6 DDX39A SNRNP200 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 CTNNBL1 SRSF5 HNRNPC SRSF6 SLU7 SRSF7 SRSF9 FYTTD1 PRCC LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 CCAR1 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB PCBP1 NXF2B PCBP2 RNPS1 SYMPK PPP1CB RBM10 DHX15 DHX16 WBP11 DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 CSTF2T SMNDC1 UBA52 U2SURP CLP1 SNRPD2 SNRPD1 HNRNPF HNRNPA2B1 SNRPD3 SNRPA1 UBB SF3B4 UBC SF3B5 SF3B2 SF3B3 SF3B6 RPS27A SF3A3 SF3A1 SF3A2 XAB2 CHERP PUF60 SNRPB2 AQR PRPF19 PCF11 PTBP1 HNRNPH1 NUP214 EFTUD2 HNRNPA1 HNRNPM HSPA8 RBBP6 ZCRB1 SNRPG SNRPE SNRPF SNRPB DDX5 NUP107 NUP188 NUP210 GTF2F1 GTF2F2 NUP93 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 NUP62 STEEP1 TCERG1 GPATCH1 PNN METTL3 ZNF830 SF1 NUDT21 SLBP NDC1 DHX8 SEC13 PRKRIP1 CWF19L2 NCBP1 SNU13 NUP133 RNPC3 NCBP2 HTATSF1 FUS WDR70 DHX35 ISY1 ZRSR2 PRPF38A PABPN1 SMU1 BCAS2 NUP50 EIF4E PPP1R10 NKAP NUP54 UBL5 PRPF40A HNRNPA3 GCFC2 GPKOW PRPF18 CDC5L SDE2 TUT1 FAM32A CACTIN PPP1R8 SRSF10 CPSF7 XRN2 SRSF12 PRPF31 PDCD7 POLR2A SF3B1 RBMX2 POLR2B DHX9 PAPOLG NUP42 SNIP1 POLR2C SNRNP35 POLR2D IK PRP4K LENG1 POLR2G SUGP1 PRPF4 NUP43 PRPF3 POLR2I SNRNP27 SNRNP25 POLR2J RAE1 SNRPC RANBP2 SNRPA SRSF8 ZMAT2 ZMAT5 CCDC12 YJU2 LSM5 LSM4 LSM3 LSM2 PPP1CA PPIE LSM8 PPIH LSM7 PPIG LSM6 NUP35 RBM25 PPWD1 DDX41 USP39 MTREX SART1 METTL14 SNRNP70 TFIP11 NUP37 SYF2 LUC7L3 HNRNPU C9orf78 NSRP1 HNRNPR WBP4 RNF113A RBM39 PPIL2 WTAP MFAP1 RBM42 ACIN1 HNRNPL SNRNP48 HNRNPK BUD13 HNRNPD TRA2B FAM50A WDR33 PHF5A PAPOLA TXNL4A SNRPN PLRG1 DNAJC8 FIP1L1 PPIL1 SNRNP40 PPIL3 PPIL4 SRRM2 CRNKL1 CSTF3 CSTF2 SNW1 CSTF1 HNRNPH2 RBM7 CWC25 CWC27 CWC22 PRPF6 PRPF8 RBMX CPSF4 CPSF1 CPSF3 CPSF2 CWC15 RBM5 YBX1 POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity STK11 MLXIPL PRKAB2 PRKAA2 ADIPOR1 ADIPOR2 ADIPOQ PRKAG2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 MUC16 MUC17 MUC19 MUC12 MUC5B MUC15 MUC20 MUC21 MUCL1 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC13 MUC6 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking YWHAE RAB9A RAB4A RAB9B RAB5A RAB8A RAB5C RAB7A OPTN AKT2 AKT3 RAB14 SBF1 SBF2 ALS2 DENND5B RABGEF1 RINL TRAPPC12 TBC1D10C TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B MAP1LC3B GABARAPL2 TRAPPC2L SYTL1 AKT1 GAPVD1 RAB32 RAB31 RAB5B TBC1D20 RAB35 TBC1D24 TBC1D25 ULK1 RAB38 DENND6B RIN3 DENND6A RIN1 RIN2 GABARAP TBC1D13 TBC1D14 TBC1D17 RAB6B TBC1D15 TBC1D16 TRAPPC2 TRAPPC3 TRAPPC1 ANKRD27 DENND4B RAB6A CCZ1B CHM DENND4A TRAPPC4 DENND4C HPS1 TRAPPC5 RAB39A CCZ1 TSC2 RAB3IP HPS4 TSC1 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 MON1A MON1B DENND1C DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB33A RAB33B TRAPPC6A TBC1D2 RABEP1 TBC1D3 TRAPPC6B TBC1D7 RAB7B ARF6 RAB1A RABGAP1 RAB1B DENND3 RAB21 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB11B RGP1 RAB11A RAB10 RAB12 RAB13 RAB18 RAB3GAP2 RAB3GAP1 RAB3A HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation HDAC6 HSP90AB1 HSBP1 HSF1 PTGES3 RPA1 VCP RPA2 YWHAE EEF1A1 HSP90AA1 RPA3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly PLEC CD151 LAMA3 COL17A1 DST LAMC2 LAMB3 ITGA6 ITGB4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TBCA TUBAL3 TUBA4A TUBA3E TUBB6 TUBB3 TUBA3D TUBA1A TUBB1 TBCE TUBA3C TUBB4B TUBB4A TUBA8 TUBA1C TUBA1B TUBA4B PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis TDRD1 TDRD12 FKBP6 PLD6 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E PIWIL4 POLR2F TDRKH POLR2H PIWIL2 PIWIL1 DDX4 HENMT1 ASZ1 POLR2K MAEL POLR2L MOV10L1 MYBL1 TDRD9 HSP90AA1 TDRD6 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity EP300 LARS1 AIMP1 POMC MC4R HINT1 TFEB AIMP2 EDNRB RPS6KA1 TNFSF11 FOXD3 EDN1 EPRS1 EDN3 UBE2I TFE3 MITF SOX10 KARS1 POU3F2 MC3R IARS1 CTNNB1 TFEC CDH1 ALX3 TBX3 MC1R ID1 MC5R SUMO1 YWHAH RARS1 YWHAB SNAI2 CREBBP XPO1 EEF1E1 YWHAZ YWHAE MARK3 GSK3B DARS1 YWHAG WNT3A PAX3 SOX2 ZIC1 SOX9 SIRT1 MAPK1 MAPK3 KIT AKT3 MARS1 HDAC1 LEF1 CSF1 QARS1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PTTG1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 PSMD12 PSMD11 UBB CDC20 PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFFR2 NPFFR1 NPFF QRFPR HCRT QRFP HCRTR2 HCRTR1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins APC DSP CASP3 LMNB1 FNTA PKP1 OCLN CTNNB1 TJP1 CASP8 CDH1 ACIN1 DSG3 BMX DSG1 BIRC2 CASP6 ADD1 CLSPN DBNL PLEC GSN VIM BCAP31 STK24 STK26 GAS2 PRKCD MAPT PTK2 DSG2 SATB1 PRKCQ TJP2 SPTAN1 CASP7 ROCK1 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c ALG6 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRNA3 CHRND CHRNA4 CHRNG CHRNE KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA KHSRP AKT1 DIS3 YWHAZ DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 MAPK11 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC13 HSPA5 PIK3C3 B2M BECN1 PDIA3 SEC23A ERAP2 ERAP1 HLA-H TAP2 TAP1 HLA-B TAPBP CALR SEC24B HLA-C SEC24A HLA-A ATG14 HLA-F SEC31A HLA-G HLA-E SEC24D SAR1B SEC24C CANX PIK3R4 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2R1B CDKN2A SGK1 MDM2 MDM4 CHEK2 RICTOR DAXX UBA52 PRR5 PDPK1 AKT2 AKT3 MLST8 CCNG1 AKT1 MAPKAP1 TP53 UBB CDK2 CCNA2 UBC CCNA1 RPS27A USP7 RNF34 USP2 PPP2R1A ATM PHF20 RFFL MTOR PPP2R5C CDK1 PPP2CA PPP2CB INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer TSC2 CDKN1B GSK3A MDM2 RICTOR FOXO6 PRR5 FOXO4 CHUK FOXO3 PDPK1 FOXO1 AKT2 AKT3 MLST8 AKT1 MAPKAP1 AKT1S1 NR4A1 RPS6KB2 GSK3B CDKN1A CASP9 MTOR BAD METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes FDX2 CYP26B1 GGT1 GSS CYP21A2 OPLAH UGT1A1 MAT1A CYP2U1 CYP27A1 CYP2R1 CYP26C1 SLC35D1 TPMT CYP24A1 FMO3 ACY1 CYP11A1 MAOA TBXAS1 CYP27B1 UGT1A4 CYP7B1 GCLC FDXR CYP11B2 AHCY CYP11B1 GCLM CYP1B1 CYP17A1 CYP4F22 CYP19A1 FDX1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACADS ACSM3 HADH ACSM6 ECHS1 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) H2AC14 H2BC21 H3-3B H2BC12L H3C8 H2AC8 H2AC6 KDM6A H2AC7 STPG4 METTL23 KDM5A H2BC17 DPPA3 KDM5B H2BC12 H2BC13 H2BC14 H2BC15 KDM6B H2AJ H2BC11 AICDA TET3 H4C9 H3C15 UHRF1 H2BC9 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX H2AC19 H2BC26 H2AB1 H2AZ2 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation CD274 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 DVL2 FZD4 PRKCA CLTC CLTB CLTA ARRB2 AP2A1 AP2B1 AP2A2 AP2S1 PRKCG WNT5A PRKCB DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia PROC F5 PROS1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H POLR3K POLR2H POLR1C POLR1D POLR2K POLR2L BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis H2AC14 SUN2 H2BC12L FKBP6 H2AC8 H2AC6 H2AC7 UBE2I ACD TINF2 TERF1 TERF2 RAD51C POT1 TERF2IP H4C9 H2AC20 RBBP8 ATM H2AX ATR SYCP2 SYCP1 SPO11 SYNE2 SYNE1 RAD50 SUN1 BRCA1 H2BC26 TEX12 TEX15 SMC1B RAD51 MSH4 MSH5 H2BC21 H3-3B DMC1 SYCE3 PSMC3IP H3C8 SYCE2 SYCE1 MND1 HSPA2 REC8 LMNB1 TOP3A MLH3 STAG3 SYCP3 SMC3 H2BC17 RAD21 H2BC12 H2BC13 STAG1 H2BC14 STAG2 H2BC15 SMC1A H2AJ RPA1 H2BC11 RPA2 MLH1 RPA3 H3C15 CDK4 CDK2 MRE11 H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 PRDM9 BRCA2 H2BC1 FIRRM FIGNL1 BLM H2AC19 H2AB1 H2AZ2 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway PSMA5 WNT1 FZD1 SEM1 PSMA6 DVL1 FZD3 PSMA3 DVL2 FZD2 FZD5 PSMC5 PSMA4 DAAM1 DVL3 FZD4 FZD7 PSMC6 FZD6 FZD8 PSMC3 PSMA1 CLTB PSMA2 ARRB2 PSMC4 PSMC1 PSMC2 PRICKLE1 RYK PRKCA CLTC CLTA AP2A1 AP2B1 AP2A2 AP2S1 PARD6A RAC1 SCRIB RHOA VANGL2 PFN1 UBA52 PSMD12 WNT11 PSMD11 UBB PSMD14 PSMD13 SMURF2 UBC SMURF1 WNT4 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RAC2 RAC3 PSMB2 PSMB3 PSMD2 PSMD3 PRKCG PSMB1 PSMD1 WNT5B WNT5A ROR1 ROR2 PRKCB ADRM1 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 SHC1 CDC37 ERBIN NRAS ERBB2 PTPN12 SOS1 HRAS HSP90AA1 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) CBFB CTLA4 FOXP3 IL2 RUNX1 IFNG TNFRSF18 CR1 IL2RA NFATC2 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants NOX4 NRAS PIK3R1 BCL2L1 GRB2 PIM1 PTPN11 PIK3CA STAT5A CDKN1A STAT5B SOS1 HRAS FLT3 GAB2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer SMAD2 SMAD4 SMAD3 FKBP1A TGFBR1 TGFBR2 TGFB1 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands CRH HDAC1 BDNF DLL1 SST SIN3A NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay MTREX SRRT RBM7 RBM27 NCBP1 ZCCHC7 RBM26 NCBP2 YTHDC1 ZCCHC8 ZC3H4 YTHDC2 ZC3H3 TENT4B PABPN1 WDR82 EXOSC10 ZC3H18 ZFC3H1 C1D DXO MPHOSPH6 XRN2 DIS3 PAPOLG EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 TENT4A MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation CUL1 IKBKB FBXW11 UBB IKBKG NFKB1 MAP3K8 UBC MAP2K4 MAP2K1 RPS27A TNIP2 BTRC UBA52 CHUK SKP1 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors TBX5 NPPA CES1 NKX2-5 KAT2B WWTR1 GATA4 MME HIPK1 NPR1 NPR2 HIPK2 NPPC CORIN ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway GNAT3 GNAI3 GNAL GNAI1 GNAI2 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME ABCC2 PON3 SLCO1B1 PON1 SLCO1B3 CYP3A4 UGT1A3 ABCB1 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell HGS UBB MET STAM UBC EPS15 STAM2 RPS27A SH3KBP1 SH3GL2 UBA52 SH3GL3 CBL SH3GL1 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD OPLAH RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle CCNE1 CUL3 HGS PLIN3 VHL RHOBTB3 RAB9A LRRC41 RAB9B SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination ERCC3 UBTF ERCC2 TBP POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H CAVIN1 CDK7 TAF1D TAF1B TAF1C GTF2H1 GTF2H2 MNAT1 GTF2H3 TAF1A GTF2H4 POLR2E GTF2H5 POLR2F POLR2H CCNH POLR2K POLR2L TTF1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT1 DPEP2 CYP1A2 DPEP1 AKR7A2 CYP3A4 AKR7A3 CYP2A13 GGT3P ACY3 ACY1 MGST3 CYP3A5 MGST1 MGST2 AKR7L GGT5 GGT7 GGT6 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events RPS6KA3 PIK3R2 EDNRB RPS6KA2 RPS6KA1 PIK3R1 EDN1 EDN3 PIK3CA NPFFR2 NPFFR1 NPFF QRFPR HCRT QRFP HCRTR2 HCRTR1 F2R F2 EGFR KNG1 PLCB3 PLCB4 TRPC7 GCG PLCB1 TRPC6 PLCB2 TRPC3 AGT CHRM3 OXTR RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R PRKCH TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 PRKCQ FPR2 LPAR4 ITPR1 NTSR1 ITPR2 NTSR2 GPR17 NMB ITPR3 XCR1 NMBR LPAR5 LPAR6 RASGRP2 NMS RASGRP1 NMU GNRH2 GNRH1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 GAST FFAR2 GPR39 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R AVPR1B P2RY10 P2RY11 AVPR1A GPR4 GPR143 MT-RNR2 F2RL1 F2RL2 AVP F2RL3 DGKG DGKE DGKD CHRM1 DGKB GPR68 DGKA PRKCD GPR65 PRKCA PMCH CHRM5 ABHD12 RGS4 RGS5 PRKCE RGS2 RGS3 RGS1 GHSR CASR DGKZ LTB4R2 DGKQ UTS2 DGKK DGKI DGKH ABHD6 NTS MCHR2 HRH1 GRK5 TAC3 GRK2 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2C OXT HTR2A TRH GRM1 LTB4R GRM5 BDKRB2 BDKRB1 GNRHR2 XCL2 XCL1 MAPK1 DAGLB RGS18 MMP3 RGS17 MAPK3 RGS19 BTK RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 SOS1 CCK KISS1 KALRN HRAS CYSLTR1 CYSLTR2 FFAR1 NRAS SAA1 ADRA1D ADRA1B ADRA1A TBXA2R PIK3R3 ARHGEF25 GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GCGR GNB4 GNB3 GNB5 GNGT1 GNGT2 APP GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MCHR1 MAPK7 HBEGF TRIO MGLL GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI1 GLI3 GLI2 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs CALM1 PRKAB2 PRKAA2 PRKAB1 PRKAG1 PRKAG2 PRKAG3 CAMKK2 PRKAA1 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS PLA2R1 PLA1A OSBPL10 PLA2G4F PLA2G12A PLA2G5 PLA2G2F PLA2G4D PLA2G2D PLA2G4E PLA2G2E PLA2G4B PLA2G4A PLA2G2A PLAAT3 OSBPL8 MBOAT1 OSBPL5 LPCAT4 LPCAT3 PLA2G10 PLA2G1B DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 PRIM2 MCM2 PRIM1 POLA1 POLA2 PCNA LIG1 RPA1 RPA2 POLD1 DNA2 RPA3 RFC5 RFC3 RFC4 RFC2 RFC1 POLD3 FEN1 POLD4 GINS1 POLD2 GINS2 CDC45 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 CSF2RB SFTPA1 CSF2RA SFTPD SFTPB SFTA3 SFTPA2 SFTPC INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation DPP4 GNAT3 FFAR1 TCF7L2 LEP FFAR4 PAX6 GNG13 SPCS3 CTNNB1 GRP SPCS2 SEC11A SPCS1 GNB1 SEC11C GNB3 GCG GATA4 PCSK1 ISL1 CDX2 GPR119 GIP ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization IGLV1-44 IGKV3-15 IGKV3-11 PIK3R2 LYN SYK V2-8 PIK3CB V1-20 PIK3R1 IGKV2D-40 IGHV3-11 IGHV3-13 FYN IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 PIK3CA IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 PDPK1 V1-9 V5-4 V1-7 V5-1 V1-5 GAB2 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHV3-23 IGLV IGLV2-8 SOS1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 LAT2 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 PAK2 ARHGAP10 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDKN2A CDK4 CDK6 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins TACR2 TACR3 TAC3 TACR1 TAC1 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance AMN HDLBP CUBN APOA1 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions SHH HHIP PTCH1 BOC GAS1 CDON DHH IHH RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle CAPZB DBT SRRM1 DDX39B DOCK2 CDC42 MTMR1 HGS RAB7A LMNB1 IQGAP1 PAK2 SLC1A5 LETM1 TIAM1 RAPGEF1 FRS3 SOS1 LAMTOR1 STEAP3 CUL3 RASAL2 SHMT2 AAAS PIK3R3 WASL CLTC MTR DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 WDR6 NDUFS3 FLOT2 FAM83B DSP CDC37 ANKRD26 ERBIN DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 PLD1 CKAP4 KTN1 NISCH PLD2 VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 ITGB1 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 TRIO JAG1 TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L PREX2 PREX1 WDR91 EPSTI1 ANKFY1 CEP97 FNBP1 STARD8 BCR PIK3R2 DAAM1 WDR81 PIK3R1 NGEF IQGAP2 IQGAP3 ABR FRS2 MYO6 PIK3CA NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARHGAP8 ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 EMD NUDC RRAS2 GMIP CIT CCP110 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 FGD1 FGD2 FGD3 LMAN1 FGD4 FGD5 CHN2 HSP90AA1 CHN1 STX5 YKT6 FARP2 FARP1 KIDINS220 USP9X MCF2 WWP2 DEF6 WDR11 TMEM59 TAOK3 ABI2 VMA22 GJA1 SHKBP1 ABI1 GOPC FILIP1 PKN2 PKN1 PLXND1 NCF1 FAM13B NCF2 FAM13A NCF4 MSI2 STK10 SLK POTEE GOLGA8R TPM4 RALGAPA1 TPM3 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 OBSCN PHIP RHOBTB1 RHOBTB2 STIP1 DDRGK1 STK38 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 COPS4 NSFL1C COPS2 NOXA1 PLXNB1 MAP3K11 ARHGAP11A ZNF512B ARHGAP11B RASGRF2 SNAP23 BRK1 TAGAP EFHD2 NCK2 NCK1 PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 PTPN13 ARFGAP2 LCK DSG2 SOS2 BLTP3B SRC ROCK2 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF1 WASF2 WASF3 RNF20 PCDH7 CDC42BPB CDC42BPA BAIAP2 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 SPATA13 HMOX2 CFTR GRB7 TMEM87A GARRE1 TWF1 KALRN SCFD1 SPTBN1 STAM NET1 ANLN FAF2 KIF14 SH3RF1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC2 RAC3 SPTAN1 GIT1 VCP VAV3 RHOG RHOH RHOF CKB RHOC ACTB RHOD VAV1 VAV2 RHOB ARHGEF9 RHOJ ARHGEF3 ARHGEF4 CAV1 ARHGEF1 RHOU RHOV ARHGEF2 ARHGEF7 DBN1 ARHGEF5 RHOQ ARHGEF6 AMIGO2 HSP90AB1 WAS NOXO1 PAK1 SAMM50 PGRMC2 PLEKHG4B EMC3 PAK6 PAK3 PAK5 PAK4 BCAP31 IL32 GIT2 MTX1 CAVIN1 MYO9B MYO9A MPP7 DLC1 TRIP10 ESYT1 OCRL TJP2 RTKN PRAG1 ARHGDIG ARHGAP39 ACTG1 SYDE2 ARHGAP44 SYDE1 ARHGAP42 ARHGAP40 ACBD5 BASP1 ARHGDIA ARHGDIB LBR ARHGEF40 RALBP1 CYBB CYBA KCTD3 ARHGAP45 ALDH3A2 STAM2 ABCD3 ARHGEF26 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 ARHGAP22 ARHGAP20 RHPN1 RHPN2 ECT2 CPSF7 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 VAPB ARHGAP33 ARHGAP32 DIAPH1 CCT6A DIAPH2 ARHGAP31 DNMBP ARHGAP30 DIAPH3 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 TUBA1B ARHGEF15 ATP6AP1 ARHGEF17 ARHGEF16 CCT2 ARHGEF19 ARAP2 ARHGEF18 ARAP3 SENP1 ARHGAP10 TIAM2 ZAP70 GFOD1 ALS2 PEAK1 PDE5A CCDC187 MOSPD2 FAM169A ADD3 UACA GNA13 TRA2B PTK2B STOM SPEN HSPE1 CCT7 SLC4A7 FMNL3 FMNL1 ACTC1 FMNL2 VIM DOCK7 ARHGAP35 RAC1 DOCK10 DOCK11 ARAP1 RHOA ELMO2 DOCK1 RACGAP1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation IRS2 PIK3CA IRS1 PIK3R2 PIK3CB PIK3R1 NTRK1 RHOA NGF REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane OST4 OSTC STT3A SPCS3 CTNNB1 SPCS2 CDH1 SPCS1 PIP5K1C PRKCSH JUP DDOST DAD1 FURIN PCSK7 CSNK2A3 GANAB ANK3 TMEM258 ARHGAP32 MOGS SEC11A SEC11C CSNK2A1 PCSK6 RPN2 CSNK2A2 POMT2 CANX RPN1 POMT1 CSNK2B TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 CD4 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PSMD3 PSMB1 PSMD1 SKP1 ADRM1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2AC14 EP300 H2BC12L H2AC8 MYL9 H2AC6 H2AC7 KMT2D KMT2A KMT2C TNRC6C KMT2B MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B CBFB H4C9 RUNX1 SETD1B PRMT1 SETD1A H2AC20 H2AX DPY30 ASH2L H2BC26 SIN3B SIN3A H2BC21 H3-3B H3C8 WDR5 H2BC17 H2BC12 H2BC13 H2BC14 KAT2B H2BC15 H2AJ ZFPM1 GP1BA H2BC11 PRMT6 GATA1 H3C15 NFE2 HDAC1 H2BC9 PF4 H2BC8 H2BC5 H2BC3 ITGA2B NR4A3 H2BC1 PRKCQ RBBP5 THBS1 H2AC19 H2AB1 H2AZ2 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism GLYCTK ALDOB ALDH1A1 AKR1B1 SORD KHK TKFC SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression TP53 PRDM1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation ARHGDIA NGFR RHOA NGF CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP H2BC14 H2BC15 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 MPG H2BC1 H2AX H2AC19 H2BC26 NEIL3 H2AB1 H2AZ2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) DPP4 GNAT3 FFAR1 TCF7L2 LEP FFAR4 PAX6 GNG13 SPCS3 CTNNB1 GRP SPCS2 SEC11A SPCS1 GNB1 SEC11C GNB3 GCG PCSK1 CDX2 GPR119 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR NRAS PIK3R1 PTPN12 ARHGEF7 SPRY2 SH3KBP1 PIK3CA CDC42 ADAM10 ADAM17 GAB1 EGF AREG PLCG1 EGFR EPS15 PTPN11 EPGN SRC SH3GL2 CSK SH3GL3 SH3GL1 FAM83B HGS STAM2 EREG BTC UBA52 HBEGF SOS1 PXN CBL SHC1 UBB STAM UBC TGFA RPS27A PTPRK EPS15L1 EPN1 ADAM12 LRIG1 FAM83D AAMP PAG1 FAM83A SPRY1 PTPN3 HRAS ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling NRG3 NRG4 PTK6 EGF ERBB2 EGFR HBEGF NRG1 NRG2 EREG BTC GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation JMJD7 RCCD1 SUMF2 EIF5A2 SUMF1 DNAJC24 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 ZC3H15 RWDD1 RIOX2 FN3K ICMT DOHH RIOX1 DRG1 DRG2 PROS1 RPS23 GGCX ARSB GAS6 F2 F7 F8 U2AF2 F9 ETF1 PROZ ARSA F10 EEF2 PROC ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD JMJD6 RPL27A ASPH BGLAP RPL8 STS RPS6 FURIN TPST2 TPST1 KDM8 OGFOD1 EIF5A JMJD4 DHPS FN3KRP REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes TLE2 TCF7L2 TLE1 TLE5 TCF7 HDAC1 LEF1 TCF7L1 CTBP2 TLE4 CTBP1 TLE3 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGFR NGF HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation EIF5A2 EIF5A DHPS DOHH REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade C3 CFB CLU PROS1 CD81 CPB2 CFH C5AR2 CD19 C5AR1 CFI C2 C5 C6 C7 C9 C8B C8A F2 C8G CR2 CD46 C1QB C1R CPN2 SERPING1 CPN1 CD59 CD55 CFHR2 CFHR1 CFHR4 CFHR3 C3AR1 CFHR5 C1QC C1S IGHV3-23 IGLV IGLV2-8 IGKV1-16 C4A IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 VTN IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 C4B_2 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CR1 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 ELANE IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1QA C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation NCBP1 NCBP2 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 GTF2F1 FGF23 GTF2F2 FGF6 FGF2 FGFR2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J FGF7 POLR2E POLR2F POLR2H FGF22 FGF3 FGF10 POLR2K POLR2L REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function H2AC14 H2BC12L OST4 OSTC STT3A MYC MDM2 MYCN PIP5K1C PRKCSH TNRC6C JUP MOV10 AGO3 TCF3 AGO4 AGO1 AGO2 SNAI1 DDOST SNAI2 CTNNA1 TNRC6A TGIF2 DAD1 TNRC6B H4C9 STRAP SMARCA4 GANAB TFAP2A H2AC20 FOXQ1 DNTTIP1 ZBTB33 EZH2 FOXP2 H2AX ZEB2 PKM ZEB1 POMT2 MCRIP1 FOXJ2 KLF9 POMT1 H3-3B VCL H3C8 TCF12 SIRT1 H2AJ UBA52 ZNF217 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 SUZ12 UBC H2BC9 H2BC8 H2BC5 ARHGAP32 PSMA7 MOGS H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 RPN1 PSMB1 PSMD1 MPHOSPH8 H2AB1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 CTBP2 PSMC2 CTBP1 CTNNB1 CDH1 ZMYM2 SP1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 SEC11A SEC11C DNM2 SRC CSNK2A1 PCSK6 FOXA2 CSNK2A2 CANX CSNK2B CTSS H2BC26 KLF4 H2BC21 CTSL KDM1A TWIST2 EED TWIST1 CTSB ARID1A H2BC17 SPCS3 MAPK1 SPCS2 H2BC12 SPCS1 H2BC13 H2BC14 MAPK3 H2BC15 H2BC11 TLE1 HDAC2 FURIN PCSK7 HDAC1 CSNK2A3 ANK3 TMEM258 KMT5A RBBP4 RB1 RBBP7 H2AC19 WT1 H2AZ2 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones H2AC14 HMG20B H2AC8 H2AC6 H2AC7 SAP30 TBL1XR1 H2BC18 HDAC8 H4C9 SUDS3 REST H2AC20 CHD4 CHD3 H2BC26 HDAC10 H2AC17 H2AC12 H2BC21 H3C8 KDM1A H2BC17 H2AC25 H2BC12 H2AC21 NCOR2 H2BC13 H2BC14 H2BC15 NCOR1 H2BC11 PHF21A GPS2 HDAC2 H3C15 TBL1X HDAC3 MBD3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 H2BC1 ARID4A SAP30L RCOR1 GATAD2B SAP18 GATAD2A RBBP7 MTA2 MTA3 H2AC19 H2AC1 ARID4B BRMS1 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling EP300 CRTC1 NCOA1 NCOA2 NPAS2 NCOA6 CLOCK MED1 LY96 MEF2C RORA APOA1 ATF2 TBL1XR1 SIRT1 HMOX1 HELZ2 RXRA TLR4 NR1D1 NCOR1 PGRMC2 NRIP1 PPARGC1A PPARA TGS1 CREBBP XPO1 BACH1 TBL1X APOB HDAC3 SMARCD3 MAFK NFE2L2 CHD9 BMAL1 CARM1 SLC46A1 HBA2 HBB CRTC2 CRTC3 RAI1 CLEC1B MEF2D INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism NUP37 IP6K1 IP6K3 NUP107 PLCG2 IP6K2 NUP188 NUP210 IPMK NUP93 MINPP1 NUP205 IPPK POM121 PLCH1 NUP214 PLCH2 PTEN AAAS PLCG1 NUP160 POM121C IMPA1 NUP85 IMPA2 TPR NUP88 OCRL MIOX ITPK1 NUP155 ITPKB ITPKC NUP153 PLCB3 SYNJ1 PLCB4 ITPKA PLCB1 PLCB2 NUP62 CALM1 INPPL1 PLD4 NDC1 SEC13 INPP4A INPP4B MTMR9 PPIP5K1 PPIP5K2 NUP133 PLCZ1 NUP50 MTMR7 NUP54 PLCD3 PLCD4 PLCD1 INPP5B NUDT3 NUDT4 INPP5A ISYNA1 INPP5D INPP5J NUP42 NUDT11 PLCE1 INPP1 NUDT10 NUP43 RAE1 RANBP2 NUP35 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells EPCAM UPK1A SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants SHC1 GAB1 CDC37 ERBIN EGF NRAS PIK3R1 ERBB2 PLCG1 EGFR PIK3CA SOS1 HRAS HSP90AA1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere CHTF18 CHTF8 CTC1 STN1 TEN1 PRIM2 PRIM1 ACD POLA1 TINF2 POLA2 PCNA TERF1 TERF2 POT1 TERF2IP POLD1 RFC5 RFC3 RFC4 RFC2 RFC1 POLD3 POLD4 POLD2 DSCC1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation ANOS1 TGFBR3 GIPC1 FGF1 FGF4 FGF22 FGF3 FGF9 FGF10 FGF20 FGF23 FGF6 FGF2 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling VAV2 PIK3R2 SYK PIK3CB NRAS TREM2 PIK3R1 KLRK1 GRAP2 RAC1 FYN KLRC2 TYROBP KLRD1 LCP2 PLCG2 PIK3CA BTK SOS1 B2M PLCG1 LCK HLA-E VAV3 HRAS FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription EP300 POMC SIRT3 BBC3 CCNG2 CAV1 BCL6 NR3C1 TXNIP TXN G6PC1 YWHAQ FOXO6 PLXNA4 FOXO4 FOXO3 FOXO1 PPARGC1A YWHAB ATXN3 CREBBP CAT SREBF1 DDIT3 RETN AKT1 PCBP4 YWHAZ RBL2 ABCA6 FBXO32 GADD45A STK11 CDKN1A TRIM63 YWHAG GCK KLF4 BTG1 SIN3A NFYA NFYB CDKN1B NFYC INS FASLG PINK1 SIRT1 CITED2 KAT2B SOD2 NPY AKT2 AKT3 HDAC2 SMAD2 AGRP SMAD4 SMAD3 HDAC1 FOXG1 IGFBP1 PCK1 MSTN BCL2L11 SFN THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 GTSE1 PSMC2 FKBPL HSP90AB1 MAPRE1 UBA52 CCNB2 TP53 PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PLK1 CDKN1A PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 HSP90AA1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex PIK3C3 UVRAG BECN1 ISCU CHMP3 CHMP6 CHMP2B CHMP7 CHMP2A PIK3R4 MAP1LC3B CHMP4C CHMP4B CHMP4A DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX CYP27A1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) POLE4 POLE2 POLE3 PCNA PARG PNKP POLB MBD4 PARP1 SMUG1 NEIL2 APEX1 ADPRS LIG1 RPA1 RPA2 POLD1 RPA3 OGG1 RFC5 RFC3 RFC4 RFC2 POLE RFC1 PARP2 MPG LIG3 TDG POLD3 NTHL1 FEN1 POLD4 POLD2 NEIL1 XRCC1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation STAT3 ERLIN2 BCR PIK3R1 LRRFIP1 STAT1 PIK3CA FGF1 ZMYM2 FGF4 FGF9 FGF20 FGF23 CPSF6 GAB2 FGF6 TRIM24 FGF2 CUX1 FGFR1 STAT5A STAT5B BAG4 FGFR1OP2 CEP43 MYO18A IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer EPGN EGF AREG EGFR HBEGF TGFA EREG BTC BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ELAC2 ANG DICER1 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism GNAT3 FFAR1 POMC FFAR4 VAMP2 INHBB BCHE INHBA CTNNB1 GRP LHB CPB2 ISL1 PAX6 MYO5A SEC11A SEC11C INHA STX1A GCG KLF4 TCF7L2 RAB27A CTSG KIF5C KIF5B INS KIF5A CTSD SPCS3 SPCS2 SPCS1 CGA AGT PCSK2 EXOC8 UCN EXOC7 GATA4 ERO1B MME CTSZ PCSK1 ANPEP TSHB CPA3 CDX2 SLC30A8 GPR119 ACHE FSHB GIP SLC30A5 EXOC4 DPP4 ATP6AP2 EXOC3 LEP MYRIP EXOC6 P4HB EXOC5 ENPEP EXOC2 CPB1 PLA2G7 EXOC1 CRHR2 CLTRN ACE IGF1 MBOAT4 INHBC CMA1 GNG13 INHBE CES1 GZMH CPE CGB8 REN GNB1 ACE2 GNB3 GH1 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling EBI3 STAT3 IL27 JAK1 IL6ST CRLF1 IL27RA JAK2 CANX TYK2 STAT1 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation MRTFA TRIM28 CDCA8 MITF NUP107 MDM2 NUP188 NUP210 HNRNPC PPARGC1A NUP93 CREBBP H4C9 NUP205 POM121 TRIM27 AAAS NUP160 POM121C VHL NUP85 CETN2 TPR BIRC5 NUP88 TFAP2B TFAP2C XRCC4 INCENP NUP155 AURKB EIF2AK2 TOPORS NUP153 PML RELA NUP62 NCOA1 NCOA2 CDKN2A NDC1 SEC13 SMC3 NUP133 RAD21 ZNF350 STAG1 NCOR2 STAG2 RANGAP1 SMC1A NUP50 NUP54 NRIP1 PCGF2 AURKA NUP42 SUZ12 NUP43 RAE1 RANBP2 SMC5 SMC6 PARK7 DDX17 NSMCE3 NSMCE2 XPC NSMCE1 HIC1 NUP35 EID3 ZBED1 TP53BP1 EP300 SP3 TOP2A TOP2B ZNF131 SENP5 SENP1 NUP37 PIAS4 FOXL2 SENP2 HDAC4 PIAS3 SAFB THRB RNF168 UBE2I NSMCE4A VDR NFKB2 TOP1 SP100 NR1H2 RORA NFKBIA UHRF2 MDC1 NR3C1 CASP8AP2 CTBP1 ESR1 NOP58 NR2C1 RWDD3 NR3C2 MBD1 PIAS1 RAD52 DNMT1 HNRNPK NR5A1 NR4A2 AR RXRA DAXX SUMO1 SUMO3 SUMO2 RARA PPARG PGR PPARA IKBKE TP53 NUP214 BMI1 CBX5 IKBKG RING1 SATB1 RNF2 HDAC7 CBX8 PHC2 CHD3 PHC1 BRCA1 CBX4 CBX2 SIN3A ING2 PHC3 DNMT3B HERC2 DNMT3A PCNA WRN PARP1 NPM1 RPA1 HIPK2 HDAC2 HDAC1 UBA2 SAE1 L3MBTL2 MTA1 TDG BLM DDX5 SATB2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR CTSL HSP90B1 LGMN CTSK UNC93B1 CTSB CNPY3 TLR8 CTSV TLR7 TLR9 CTSS TLR3 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis FLOT2 CDC37 RIPK3 TRADD MLKL PDCD6IP TNFRSF10B FASLG TNFRSF10A TRAF2 XIAP CASP8 TNFSF10 FAS RIPK1 FADD STUB1 UBA52 BIRC2 PELI1 BIRC3 UBB UBC PRKN ITCH RPS27A SDCBP OGT FLOT1 UBE2L3 HSP90AA1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 S100A1 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 FGB FGA PELI1 LRRC14 FGG TRAF6 USP14 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 TLR1 PPP2R1A S100A9 S100A8 TLR2 BTRC RELA SKP1 CD36 FBXW11 NFKB1 LY96 TRAF2 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT SOCS1 DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 SIGIRR IRAK3 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TIRAP PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 TLR6 FOS MAP2K1 MAPK1 MAPK3 BTK MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e DPM1 DPM2 DPM3 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling ANOS1 MKNK1 SPRY2 MAPK1 FRS2 BRAF MAPK3 FGF1 FGF4 UBA52 FGF9 FGF20 FGF23 CBL FGF6 FGF2 UBB UBC RPS27A PTPN11 PPP2R1A FGF22 FGF3 FGF10 PPP2CA PPP2CB SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 NRAS PIK3R1 MKNK1 SPRY2 MAPK1 FRS2 BRAF MAPK3 PIK3CA FGF1 FRS3 FGF4 FGF16 UBA52 FGF9 FGF18 FGF20 SOS1 FGF23 CBL FGF6 FGF2 KLB GAB1 UBB PLCG1 UBC FGF19 FGFR4 RPS27A PTPN11 PPP2R1A PPP2CA HRAS PPP2CB RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle WDR6 DST PIK3R1 TXNL1 USP9X PEAK1 RHOV IQGAP1 ARHGEF7 VANGL1 PAK2 DEPDC1B DLG5 MAP3K11 ARHGAP12 ZNF512B WASL PAK1 CDC42 EPHA2 PAK6 NCK2 NCK1 PAK4 SPTBN1 GIT2 MYO9A CLTC CCP110 SH3RF1 TPM4 TPM3 PARD6B PARD6A SPTAN1 GIT1 CEP97 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle EDEM3 EDEM1 AMFR SYVN1 DERL2 RNF5 EDEM2 RNF103 RNF139 OS9 TRIM13 UGGT2 UGGT1 PSMC1 RNF185 MARCHF6 PRKCSH UBXN1 NGLY1 UBA52 MLEC ENGASE MAN1B1 UBB PDIA3 UBC GANAB CALR MOGS RPS27A RAD23B SEL1L VCP CANX DERL1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions RHOB MYL6 PLXNA1 MYL9 FYN MYH9 HSP90AB1 PIP5K1C PLXNB1 NRP1 PLXNA4 PAK1 DPYSL4 LIMK2 DPYSL5 LIMK1 DPYSL2 DPYSL3 PLXNC1 SEMA6A PAK3 SEMA6D ITGA1 SEMA7A SEMA3A CRMP1 MET SEMA3E RRAS ERBB2 PLXNA2 PLXNA3 SEMA4A CD72 SEMA4D CDK5 PTPRC FES PLXNB3 ROCK2 GSK3B SEMA5A ROCK1 CDK5R1 TLN1 HSP90AA1 FARP2 TREM2 ARHGAP35 RAC1 TYROBP CFL1 RHOA PAK2 ITGB1 MYH14 MYH11 MYL12B MYH10 PLXND1 RND1 ARHGEF11 ARHGEF12 RHOC PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 GAB1 PIK3R1 PTPN11 FRS2 PIK3CA FGF1 FGF7 FGF4 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 FGF23 FGF6 FGF2 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME AKR1C1 UGT2B7 UGT2B17 HSD11B1 ALB SERPINA6 HSD11B2 CYP3A4 UGT1A3 ABCB1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis TCF12 MEF2A MEF2C CTNNB1 MYF6 TCF4 MYF5 TCF3 CDC42 CTNNA1 ABL1 MYOG CDON MYOD1 NTN3 CDH4 CDH2 BNIP2 CTNNA2 NEO1 SPAG9 MEF2B MAPK12 CDH15 MAP2K6 MAPK14 MAPK11 MEF2D POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation NUP62 NUP205 POM121 TNPO1 RAN NUP37 NDC1 UBE2I NUP160 AHCTF1 SEC13 NUP85 NUP43 NUP133 NUP107 NUP155 NUP188 RANGAP1 RCC1 SUMO1 NUP54 KPNB1 NUP93 NUP35 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening CACNA1A CACNB2 CACNB1 CACNB3 CACNA2D2 CACNG2 CACNB4 CACNA2D1 CACNG4 CACNA2D3 CACNA1E CACNA1B DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling CDC37 ERBIN NRG1 PTPN12 NRG2 EREG BTC NRG3 NRG4 STUB1 UBA52 RNF41 HBEGF CUL5 AKT2 AKT3 AKT1 UBB EGF ERBB2 EGFR UBC RPS27A PTPN18 USP8 HSP90AA1 MATK INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 H2AC14 H2BC12L MYL9 CCND3 CCND2 SMARCC1 SMARCC2 SPI1 AUTS2 IL2 IL3 TNRC6C MOV10 AGO3 TCF3 AGO4 LDB1 AGO1 GPAM AGO2 TNRC6A TNRC6B ELF1 CLDN5 CREBBP ELF2 CCND1 CBFB H4C9 RUNX1 SETD1B SETD1A SMARCA2 SMARCA4 H2AC20 PTPN11 H2AX ASH2L PML RSPO3 CTLA4 H3-3B H3C8 TCF12 PAX5 TAL1 ACTL6A SERPINB13 KAT2B H2AJ UBA52 PRMT6 PBRM1 IFNG ACTL6B PCGF5 H3C15 PSMD12 RYBP PSMD11 UBB PSMD14 PSMD13 UBC H2BC9 PF4 H2BC8 H2BC5 CSF2 PSMA7 H2BC3 ITGA2B PSMB6 RPS27A PSMD8 H2BC1 PRKCQ PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 ARID2 PSMD3 PSMB1 PSMD1 H2AB1 ADRM1 EP300 PSMA5 SEM1 FOXP3 PSMA6 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ESR1 BLK KMT2D KMT2A KMT2C KMT2B ABL1 CDK6 BMI1 PRMT1 SOCS4 CDK7 RING1 CR1 MNAT1 RNF2 SRC CSNK2A1 CSNK2A2 TP73 YAF2 CBX8 DPY30 AXIN1 PHC2 CBX6 CTSV PHC1 TNFRSF18 CSNK2B H2BC26 CBX4 SIN3B CBX2 NFATC2 SIN3A MYB H2BC21 PHC3 CTSL CTSK WDR5 ARID1A OCLN H2BC17 ARID1B TJP1 IL2RA H2BC12 H2BC13 H2BC14 H2BC15 ZFPM1 GP1BA H2BC11 LGALS3 GATA3 GATA2 GATA1 LMO1 HIPK2 LMO2 SOCS3 LIFR SMARCD1 KCTD6 SMARCD2 NFE2 SMARCD3 HDAC1 ITCH NR4A3 RBBP5 SMARCB1 CCNH THBS1 H2AC19 YAP1 SMARCE1 PRKCB H2AZ2 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBB TICAM2 UBC LY96 TAB3 TAB2 TAB1 RPS27A TICAM1 CD14 TLR4 UBA52 MAP3K7 IRAK2 TRAF6 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization XIAP UBB NEDD4 PTEN UBA52 UBC PML RPS27A USP7 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT9A SFRP1 SFRP2 WIF1 SOST WNT4 KREMEN1 KREMEN2 WNT3A DKK1 WNT5A DKK2 DKK4 LRP5 LRP6 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol TYW3 TYW2 TYW1 LCMT2 QNG1 URM1 WDR4 THADA EPRS1 LAGE3 OSGEP THG1L ALKBH8 TRMT44 TRDMT1 TP53RK PUS3 TRMT10A METTL1 NSUN2 TPRKB ADAT1 NSUN6 TRMT1 CDKAL1 PUS7 FTSJ1 TRIT1 ADAT3 ADAT2 DUS2 TRMT9B QTRT1 GON7 QTRT2 CTU2 CTU1 TRMT6 TRMT13 TRMT11 TRMT61A TRMT112 TYW5 TRMT5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway FANCC ERCC4 ERCC1 WDR48 UBA52 RPA1 RPA2 RPA3 CENPS UBB DCLRE1B UBC ATRIP DCLRE1A FAAP24 FAAP20 MUS81 USP1 RPS27A FAAP100 POLN SLX4 CENPX EME1 FANCM EME2 FANCL FANCA FANCB FANCD2 FANCE SLX1B FANCG ATR FANCF UBE2T FAN1 FANCI SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state PSMA5 CDT1 CDC6 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SKP2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 CDC26 CDC27 MCM7 MCM8 ANAPC7 UBE2C MCM3 UBE2E1 MCM4 MCM5 MCM6 MCM2 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RBX1 UBA52 CCNE2 CCNE1 CUL1 PSMD12 PSMD11 UBB PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 GMNN PSMB1 PSMD1 ORC5 ORC4 ORC6 ORC1 ORC3 ADRM1 ORC2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS ABCC2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL8 CX3CR1 CXCL1 CXCL13 CXCL3 CXCL2 CX3CL1 CXCL5 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CXCR1 CCR6 CCL5 CXCR3 CCL4 CXCR2 CCL2 CCR2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 CCL27 CCL3 CCR5 XCL2 XCL1 CXCL12 CXCR4 PF4 XCR1 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling CASP8 CASP10 FAS FADD FASLG REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription PRDM8 ILF3 FOXF1 BHLHE22 ZEB2 HOXC8 SP1 SNAI1 HEYL DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells SNW1 EP300 MAMLD1 ONECUT3 ONECUT1 NOTCH1 MAML2 MAML1 RBPJ MAML3 NEUROG3 HNF1B KAT2B KAT2A HES1 CREBBP SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases CAPZB DBT SRRM1 KIF2A DDX39B KIF2C KIF2B DOCK2 CDC42 CENPE S100A9 S100A8 MTMR1 HGS RAB7A LMNB1 IQGAP1 CFL1 PAK2 SLC1A5 MYH9 CTNNB1 YWHAB XPO1 LETM1 PRKCD PRKCA YWHAZ TIAM1 MAPK14 MAPK11 RAPGEF1 MAPK1 MAPK3 FRS3 SOS1 LAMTOR1 BUB1B CDC20 STEAP3 BUB3 MAD2L1 CDC25C CUL3 RASAL2 SHMT2 NUP107 PIN1 AAAS NUP160 NUP85 BIRC5 AURKB PIK3R3 SEC13 NUP133 RANGAP1 WASL NUP43 RANBP2 NUP37 AR KDM4C CLTC MTR PPP2R5B DDX4 PPP2R5A ROCK1 PPP2R5D TNFAIP1 PPP2R5C ARHGAP5 PPP2CA PPP2CB RND3 ARHGAP21 MUC13 WDR6 NDUFS3 PPP2R1B FLOT2 FAM83B PPP2R5E DSP CDC37 ANKRD26 ERBIN DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 PLD1 CKAP4 KTN1 NISCH PLD2 VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 ITGB1 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 TRIO JAG1 TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MYLK PREX2 PREX1 WDR91 EPSTI1 ANKFY1 CEP97 FNBP1 PRKCB STARD8 MRTFA BCR DYNC1LI1 DYNC1LI2 PIK3R2 MYL6 DAAM1 WDR81 PIK3R1 MYL9 NGEF CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR FRS2 MYO6 PIK3CA NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARHGAP8 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 YWHAE GMIP DYNLL2 CIT CCP110 CDC42EP5 PPP1CB INCENP CDC42EP4 CDC42EP3 CDC42EP2 PPP2R1A CDC42EP1 VAMP3 PKN3 GPS1 CENPA FGD1 FGD2 CENPC YWHAG FGD3 LMAN1 FGD4 FGD5 CHN2 HSP90AA1 CHN1 FLNA STX5 PPP1R12A YKT6 FARP2 CENPT FARP1 CENPU KIDINS220 USP9X MCF2 WWP2 DEF6 DYNLL1 WDR11 TMEM59 CKAP5 CENPF TAOK3 ABI2 CENPH VMA22 CENPI MAPRE1 GJA1 SHKBP1 TAOK1 ABI1 CENPK PAFAH1B1 CENPL CENPM GOPC DYNC1I2 FILIP1 PKN2 CENPN PKN1 CENPO CENPP CENPQ CENPS PLXND1 NCF1 FAM13B NCF2 FAM13A NCF4 MSI2 STK10 SLK POTEE GOLGA8R TPM4 CLASP1 RALGAPA1 TPM3 SWAP70 DYNC1H1 VRK2 FAM91A1 NDE1 TEX2 PLK1 ARMCX3 CLIP1 OBSCN PHIP MAD1L1 PIK3R4 LIN7B RHOBTB1 RHOBTB2 SFN STIP1 DDRGK1 STK38 DVL1 DVL2 PLXNA1 DVL3 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 RPS27 NSFL1C ARPC2 CDH1 ARPC3 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ARHGAP11A ZNF512B ARHGAP11B RASGRF2 SNAP23 BRK1 TAGAP EFHD2 NCK2 SPDL1 NCK1 PLEKHG3 ACTR3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 PTPN13 KLK2 ARFGAP2 LCK DSG2 EVL PPP1R12B SOS2 BLTP3B SRC ROCK2 SRF NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF1 WASF2 WASF3 RNF20 PPP1R14A PCDH7 CDC42BPB CDC42BPA BAIAP2 PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 HMOX2 BTK PFN1 CFTR ROPN1 PFN2 GRB7 TMEM87A GARRE1 TWF1 KLK3 KALRN MYL12B SCFD1 DSN1 SCAI SPTBN1 RCC2 STAM PTK2 ZWINT NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC2 RAC3 SPTAN1 GIT1 NDEL1 VCP VAV3 H2AC19 RHOG RHOH RHOF CKB RHOC ACTB RHOD VAV1 H2AC14 VAV2 RHOB H2BC12L ARHGEF9 CTTN RHOJ ARHGEF3 ARHGEF4 CAV1 TAX1BP3 ARHGEF1 RHOU RHOV ARHGEF2 ARHGEF7 DBN1 ARHGEF5 RHOQ ARHGEF6 AMIGO2 HSP90AB1 MIS12 WAS PPP1CC NOXO1 YWHAQ PAK1 YWHAH SAMM50 PDPK1 PGRMC2 PLEKHG4B CTNNA1 EMC3 PAK6 PAK3 DYNC1I1 PIK3C3 H4C9 PAK5 PAK4 BCAP31 IL32 GIT2 MTX1 CAVIN1 MYO9B MYO9A MPP7 DLC1 TRIP10 H2AC20 ESYT1 B9D2 OCRL SPC24 TJP2 SPC25 H2AX ERCC6L RTKN PRAG1 ZWILCH ARHGDIG ARHGAP39 ACTG1 SYDE2 ARHGAP44 SYDE1 ARHGAP42 ARHGAP40 ACBD5 BASP1 CALM1 ARHGDIA H3-3B ARHGDIB KNTC1 LBR NCOA2 ARHGEF40 H3C8 RALBP1 CYBB CYBA KCTD3 ARHGAP45 ALDH3A2 SGO1 SGO2 STAM2 ABCD3 ARHGEF26 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 PMF1 H2AJ TOR1AIP1 ARHGAP12 ARHGAP22 NCKIPSD ARHGAP20 RHPN1 MYH14 MYH11 RHPN2 ECT2 MYH10 CPSF7 ARHGEF39 H3C15 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 H2BC9 ARHGAP24 H2BC8 ARHGAP23 VAPB H2BC5 ARHGAP33 ARHGAP32 H2BC3 DIAPH1 CCT6A DIAPH2 H2BC1 ARHGAP31 DNMBP ARHGAP30 DIAPH3 DLG4 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 TUBA1B ARHGEF15 H2AB1 ATP6AP1 ARHGEF17 ARHGEF16 CCT2 ARHGEF19 ARAP2 ARHGEF18 ARAP3 MEN1 SENP1 ARHGAP10 TIAM2 H2AC8 ZAP70 GFOD1 H2AC6 ALS2 H2AC7 PEAK1 PDE5A ITGB3BP CCDC187 MOSPD2 FAM169A ADD3 UACA GNA13 TRA2B PTK2B STOM BUB1 CLASP2 SPEN LIMK2 LIMK1 HSPE1 CCT7 SLC4A7 ABL1 FMNL3 FMNL1 ACTC1 FMNL2 VIM DOCK7 H2BC26 H2BC21 CDKN1B KDM1A ARHGAP35 RAC1 DOCK10 DOCK11 KIF5B ARAP1 KIF5A RHOA H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ELMO2 DOCK1 H2BC11 KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 H2AZ2 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine SLC6A3 TOMT COMT MAOA HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors GNRHR GNRHR2 LHB CGA LHCGR TSHR FSHR GPHA2 GPHB5 GNRH2 GNRH1 TSHB FSHB NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters B2M CD8B ATP6V1H ARF1 LCK AP2A1 AP1M2 HLA-A AP2B1 AP1M1 AP2A2 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 PACS1 CD28 CD4 AP1B1 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD AHCY LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux EP300 NCOA1 KDM1A NR1H3 NR1H2 TBL1XR1 NCOR2 TNRC6C RXRA MOV10 AGO3 AGO4 NCOR1 AGO1 AGO2 KDM3A TNRC6A TNRC6B KDM4A ABCA1 APOC1 GPS2 APOC4 TBL1X HDAC3 ABCG8 ABCG5 APOD RXRB APOC2 KDM1B APOE CETP ARL4C EEPD1 ABCG1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown NUP62 LEMD2 CTDNEP1 CNEP1R1 NUP37 LMNB1 NDC1 SEC13 LEMD3 NUP133 NUP107 NUP188 BANF1 NUP50 NUP54 NUP210 NUP93 NUP205 LPIN1 POM121 CCNB2 LPIN2 CCNB1 NUP214 LPIN3 NUP42 AAAS PRKCA EMD NUP160 POM121C NUP85 NUP43 TPR NEK9 NUP88 NEK6 NEK7 RAE1 RANBP2 NUP155 NUP153 PLK1 CDK1 NUP35 PRKCB VRK1 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling UBB UBC MKNK1 RPS27A SPRY2 PTPN11 MAPK1 BRAF PPP2R1A MAPK3 UBA52 PPP2CA PPP2CB CBL ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance CRTC1 MEF2C TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 MT-ATP6 TNRC6A GLUD1 TNRC6B GLUD2 YWHAE CEP57 CETN2 DYNLL2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG RAB8A MT-ATP8 CDK5RAP2 OFD1 HSP90AA1 CEP135 MICOS13 MICOS10 TUBB MCIDAS CEP131 MTERF1 HAUS4 CCDC78 HAUS3 RFX2 CSNK1D RFX3 HAUS6 TFAM HAUS5 CSNK1E CCNO APOO TUBG1 APOOL DYNLL1 TFB1M CKAP5 GABPA TUBA4A TFB2M HAUS2 PPRC1 HAUS1 AKAP9 MTX2 CEP63 GRHL3 MAPRE1 GRHL2 SFI1 DEUP1 CHCHD3 CHCHD6 POLRMT SOD2 PAFAH1B1 POLG2 SDCCAG8 GMNC DYNC1I2 DNAJC11 CPAP TMEM11 TWNK DCTN2 SSNA1 PERM1 DCTN3 FOXJ1 IMMT SSBP1 NOTCH1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 DLL1 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 SIRT4 CEP41 SIRT5 CEP43 ESRRA SIRT3 ATF2 PRKAB1 TGS1 ACSS2 TNPO1 CARM1 TP73 ARL13B PRKAG1 MAPK14 MAPK11 PRKAG3 IFT172 IFT52 E2F5 IFT57 DYNC2H1 IFT140 RPGRIP1L WDR35 IFT88 SMO NR1D1 KIF3A TTC21B INPP5E WDR19 IFT122 MKS1 PRKAB2 MED1 HCFC1 SAMM50 PPARGC1A PPARGC1B ATP5F1A ATP5F1B CREBBP ATP5F1C MTX1 ATP5F1D ATP5F1E PRKAG2 B9D2 E2F4 CRTC2 CRTC3 HSPA9 MEF2D CALM1 NCOA1 NCOA2 NCOA6 NCOR1 TBL1X CCT3 CCT2 NRF1 TCP1 ATP5MC2 ATP5MC3 TBL1XR1 ATP5MC1 HELZ2 RXRA DYNC2I2 DYNC2I1 IFT70B IFT70A TRAF3IP1 CCT8 PPARA DYNLT2B KIF17 CCT5 DYNC2LI1 CCT4 IFT74 IFT56 DYNLT5 DYNLT2 IFT80 IFT20 IFT22 ALAS1 IFT43 IFT81 CYCS IFT27 TRIP11 CHD9 DYNLRB2 DYNLRB1 IFT46 CLUAP1 IFT25 TFDP1 HDAC6 CYS1 LZTFL1 UNC119B MAPK12 ARL6 ARL3 FBF1 MCHR1 TTBK2 NPHP1 NPHP3 ATP5PF NPHP4 MARK4 RAB11FIP3 ATP5PD MYB BBS2 BBS1 RAB3IP ATP5PB BBIP1 AHI1 CEP83 PRKAA2 CEP89 GRHL1 ARF4 C2CD3 PKD2 PKD1 TCTN3 TCTN2 TCTN1 KIFAP3 CNGA2 BBS9 ATP5PO CNGA4 BBS7 CC2D2A BBS5 BBS4 IQCB1 MKKS EXOC8 EXOC7 KIF24 CAMK4 SSTR3 BBS10 RP2 BBS12 TMEM216 EXOC4 EXOC3 KIF3B EXOC6 EXOC5 EXOC2 KIF3C HDAC3 ATP5MK CNGB1 SMARCD3 EXOC1 ATP5MJ ATP5MG ASAP1 TMEM67 ATP5MF ATP5ME PDE6D RHO SEPTIN2 GBF1 SCLT1 RAB11A ATAT1 TTC8 IDH2 CEP162 B9D1 GMNN DMAC2L CEP97 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily H2AC14 EP300 H2BC21 H3-3B H2BC12L H3C8 WDR5 H2AC8 H2AC6 H2AC7 H2BC17 CTNNB1 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 DKK2 NQO1 CREBBP H4C9 CHD8 H3C15 AXIN2 CHD7 CHD6 CTCF NKD2 MAFK FAM124B H2BC9 IGF2 NFE2L2 CHD9 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX H2AC19 H2BC26 H2AB1 H2AZ2 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis ADSS2 PPAT ADSL PFAS PAICS CAD IMPDH1 IMPDH2 ATIC UMPS GART DHODH ADSS1 GMPS G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation POMC GNG10 PDYN GNG12 GNG11 GNG13 GNB2 GNAQ GNA14 GNB1 OPRM1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 GNGT2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway CD86 PAK2 CD80 PAK1 RAC1 CDC42 FYN CD28 LCK PAK3 VAV1 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release CANX CALR HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation SLC9A1 CHP1 LYVE1 HEXB HMMR HEXA CEMIP HYAL1 HYAL3 HYAL4 STAB2 GUSB SPAM1 SLC17A5 HYAL2 CD44 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage CASP4 IL1B GSDMD CASP3 IL18 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 DAG1 POMT2 POMT1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules HLA-DQB2 CD101 CD3G HLA-DRB1 HLA-DQB1 ZAP70 GRAP2 LCP2 PLCG2 PAK2 WAS PAK1 CD4 PAK3 NCK1 PLCG1 ITK TRAC LCK CD3E CD3D EVL TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 VASP TRAV19 HLA-DRB5 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 LAT ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation FCGR1A S100A1 MYD88 HMGB1 ITGB5 FGB ITGAV FGA FGG TAP2 TAP1 TAPBP TLR1 S100A9 S100A8 VAMP3 TLR2 VAMP8 CD36 CYBB CYBA LY96 CD14 UBA52 TLR4 PSME2 B2M PSMD12 PSMD11 UBB NCF1 MRC1 PSMD14 NCF2 PSMD13 HLA-H UBC NCF4 HLA-B CALR HLA-C PSMA7 HLA-A PSMB6 RPS27A PSMD8 HLA-F HLA-G PSMB7 HLA-E PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSME1 PSMC5 CD207 PSMA4 FCGR1BP PSMC6 SEC61A2 MRC2 PSMC3 SEC61A1 PSMA1 SEC61G PSMA2 SEC61B PSMC4 SEC22B PSMC1 PSMB10 PSMC2 PSMB8 PSMB9 CHUK SNAP23 IKBKB PDIA3 IKBKG TIRAP CTSV STX4 CTSS CTSL TLR6 BTK LNPEP SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound CAPZB KCNMB1 KCNMA1 VAMP2 MYH9 CLIC5 EPB41L1 RIPOR2 CIB2 PJVK ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 SYP MYO7A TMC2 MYO3B DNAJC5 MYO3A KCNQ4 GSN FSCN2 SNAP25 EZR TWF2 CAPZA1 PCDH15 CABP2 CAPZA2 USH1C CABP1 LRRC52 ESPNL EPB41L3 OTOG CDH23 CHRNA10 XIRP2 OTOF KCNN2 MYO1C EPS8L2 MPP1 GRXCR1 STX1A GRXCR2 WHRN RDX LHFPL5 OTOGL TMIE USH1G STRC MYO15A ATP2B1 SLC26A5 MSN TWF1 CASK SPTBN1 CHRNA9 CACNB2 CACNA1D RAB3A SPTAN1 CACNA2D2 SYN1 SLC17A8 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 EP300 PSEN2 APH1A APH1B TIMP2 TCF12 TGFB2 TIMP1 TGFBR1 TGFBR2 ARRB2 INHBA MYF6 MYCN TCF4 TNRC6C MYF5 RXRA MOV10 AGO3 TCF3 AGO4 SP1 AGO1 MMP14 AGO2 RARA MMP16 TNRC6A TNRC6B TGFB1 FGF2 MYOG PSENEN HELLS KLF16 SMAD4 SMAD3 MYOD1 TGFBR3 PSEN1 GIPC1 NCSTN ACVR2A INHA ARRB1 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade F2 F5 F8 F9 VWF SERPINC1 ANO6 F10 SERPIND1 F11 GP5 GP9 PROC SERPINE2 PROS1 GP1BA SERPINA5 GP1BB NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) EP300 ATF1 ELK1 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 DUSP6 DUSP7 MEF2A MEF2C ATF2 ID1 EGR1 F3 REST JUNB MAPKAPK2 CDK5 DNM2 PPP2R1A SRF CHD4 PPP2R5D CDK5R1 MAPK14 PPP2CA MAPK11 SH3GL3 PPP2CB MEF2D NAB1 NAB2 LYL1 PPP2R1B ARC MAPK7 VGF TRIB1 TPH1 RRAD TCF12 ASCL1 EGR2 EGR3 EGR4 FOS FOSL1 ID2 ID3 SGK1 CDK5R2 MAPK1 JUND MAPK3 FOSB ID4 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs LTBP4 UBE2M LTBP2 LTBP3 LTBP1 TGFB2 TGFB3 TGFBR1 TGFBR2 MTMR4 BAMBI ITGB3 PPP1CC STUB1 ITGB1 UBA52 ITGB5 ITGB8 PMEPA1 ITGAV ITGB6 CBL TGFB1 XPO1 SMAD2 UBB UCHL5 NEDD4L FURIN SMAD4 SMAD3 SMURF2 TGFBR3 STRAP PPP1R15A UBC SMURF1 USP15 NEDD8 SMAD7 RPS27A PPP1CB FKBP1A PPP1CA ITGA8 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling AKT1 UBB ERBB2 UBA52 RNF41 UBC NRG1 NRG2 AKT2 RPS27A USP8 AKT3 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP4A22 PTGIS CYP4B1 CYP4F11 CYP4F12 CYP4F22 CYP4F2 TBXAS1 CYP8B1 CYP4A11 CYP4F3 CYP4F8 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling MYD88 UBE2N TLR7 IRAK4 TLR9 IRAK1 TRAF6 IRF7 UBE2V1 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A4 SLC15A1 SLC15A3 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation IRS2 IRS1 INSR GRB10 INS INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption RSC1A1 SLC2A5 SLC5A1 SLC2A2 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism CALM1 NHLRC1 PHKG1 PHKG2 AGL UBA52 UGP2 GBE1 GAA PYGB UBB GYG2 GYG1 PYGM PYGL UBC RPS27A PGM1 PHKB PPP1R3C GYS2 EPM2A GYS1 AKR1E2 PHKA1 PHKA2 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST3GAL1 ST6GALNAC2 ST3GAL2 ST6GALNAC3 ST6GALNAC4 ST3GAL3 ST6GAL1 GALNT1 ST3GAL4 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins CAPZB DYNC1LI1 DYNC1LI2 KIF23 KIF22 KIF2A KIF2C KIF2B CTNNBL1 CENPE KIF26A CAPZA1 CAPZA2 CTR9 RTF1 DYNLL2 ACTR1A PAF1 RELA RAB7A NFKB1 DYNLL1 JUND DCTN1 EXOSC10 UBA52 C1D IGHV3-23 MPHOSPH6 IGLV IGLV2-8 IGKV1-16 DYNC1I2 CD4 IGKV1-17 IGKV1-12 FOSB DCTN2 IGHV3-7 IGHV3-9 DCTN3 V2-11 IGHV3-30 V3-4 V3-3 V2-17 UBB V3-2 IGHV3-33 V2-15 IGKV1D-39 UBC V2-19 RFC1 IGKV1D-33 TRAC IGKV2D-28 IGKV4-1 RPS27A IGHV7-81 TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 V1-11 IGKV2D-30 HLA-DQA2 DYNC1H1 V1-16 HLA-DQA1 V1-13 HLA-DPA1 IGHV4-59 IGHV1-69 TRAV19 HLA-DRB5 HLA-DRB4 HLA-DPB1 IGLV2-11 POLD3 TRAV8-4 IGLV1-40 IGLV1-47 HLA-DRA HLA-DRB3 IGLV6-57 POLD2 IGLV2-14 HLA-DQB2 STAT3 IGLV1-44 IGKV3-15 HLA-DRB1 IGKV3-11 HLA-DQB1 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 DIS3 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 EXOSC7 IGHV3-53 EXOSC6 V4-2 EXOSC5 IGLC7 EXOSC4 V4-1 EXOSC9 ITGAL IGKV5-2 EXOSC8 IGKV1-5 EXOSC3 IGLC6 EXOSC2 EXOSC1 CTSV ITGA4 CTSS CTSL CTSK E2F5 CTSD CTSB PCNA PMS2 ICAM2 IFI30 BACH2 ICAM1 ICOSLG HOXC4 SLAMF6 MLH1 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO KIF3A ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 ACTR10 CD84 HLA-DOA HLA-DOB SUPT6H ZBTB17 MSH2 VCAM1 ITGB2 AFF4 TNFSF13B POLI SMARCB1 POLH IRF8 DCTN6 IGHG3 DCTN5 IGHG4 DCTN4 MLLT1 IGHG1 MLLT3 ACTB IWS1 IGHG2 RILP MCM3AP FCGR2B DPF1 DPF2 DPF3 BCL6 C3 SMARCC1 SMARCC2 CCNK CCNT2 CCNT1 PAXIP1 SUPT16H TCF3 GTF2F1 GTF2F2 EXO1 REV1 CREBBP MAD2L2 REV3L DYNC1I1 CR2 RFC5 SUPT4H1 SS18L1 RFC3 RFC4 SMARCA2 RFC2 SMARCA4 ELOA2 E2F7 SUPT5H E2F8 ASH2L CDK9 TAF4B ELL TAF7L ELOA NELFB ELOB NELFCD NELFA SS18 ELOC CTSA NCOA6 PAX5 NELFE ACTL6A MSH6 E2F2 AICDA CTDP1 TAF9 TAF1L POLR2A POLR2B POLR2C POLR2D POLR2G IGHM POLR2I TAF9B POLR2J IGHD TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 TCEA1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 NFKB2 ICOS KMT2D KMT2C OSBPL1A MAFK MAF SKIC8 IRF4 CR1 MEF2B STAT6 DPY30 PAGR1 BCL7A MYB CD79B BCL7C CD79A BATF BCL7B IL4 WDR5 KDM6A KIF5C TBP KIF5B KIF5A ARID1A KIFAP3 ARID1B KIF20A ITGB1 KLC1 CDC73 KLC4 CEBPA KLC3 KLC2 SMARCD1 KIF3B RACGAP1 SMARCD2 KIF3C SMARCD3 LEO1 KIF18A KIF4B KIF4A RBBP5 POLR2E POLR2F POLR2H POLR2K KIF11 POLR2L KIF15 SMARCE1 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy CETN1 DYNC1LI1 TOMM20 DYNC1LI2 TOMM22 MAP1LC3A FUNDC1 ATG9A ATG12 VDAC3 VDAC2 UBE2N TOMM40 ATG5 MTERF3 TOMM7 TOMM5 TOMM6 PRKAB1 NBR1 PEX5 MFN1 USP30 MFN2 SQSTM1 MAP1LC3B DYNC1I1 TOMM70 ULK1 PRKAG2 DYNLL2 HDAC6 CSNK2A1 ATM CSNK2A2 ARL13B HSPA8 PRKAG1 CSNK2B PRKAG3 UBE2L3 HSP90AA1 PRKAA2 PINK1 DYNLL1 VDAC1 IFT88 UBA52 CFTR UBE2D2 TBK1 OPTN DYNC1I2 EPAS1 PLIN2 UBB UBC PRKN PCNT RPS27A UBE2D3 UBE2V1 DYNC1H1 PRKAB2 PLIN3 HSF1 PARK7 VCP CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress EP300 NUP37 NUP107 NUP188 HSPB8 HSP90AB1 HIKESHI CCAR2 DNAJC2 DNAJC7 CRYAB RPS19BP1 NUP210 HSPA4L HSPA14 HSPA5 HSPA13 DNAJB1 NUP93 HSPH1 BAG5 DNAJB6 CREBBP MLST8 BAG3 BAG1 NUP205 HSPA1L POM121 HSPA4 NUP214 ST13 HSPA7 HSPA6 AAAS HSPA12A HSPA12B YWHAE MAPKAPK2 NUP160 AKT1S1 POM121C NUP85 TPR EEF1A1 NUP88 NUP155 HDAC6 ATM GSK3B NUP153 ATR MTOR HSPA8 HSPA9 RPTOR HSPA1A HSP90AA1 NUP62 PTGES3 HSPA2 NDC1 SEC13 NUP133 FKBP4 SIRT1 MAPK1 MAPK3 NUP50 NUP54 RPA1 RPA2 RPA3 NUP42 NUP43 RAE1 RANBP2 CAMK2B HSPA1B HSBP1 CAMK2D HSF1 CAMK2A VCP BAG4 BAG2 CAMK2G NUP35 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death CASP8 RIPK1 CD14 RIPK3 FADD TLR4 TICAM2 LY96 TICAM1 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle CCT2 CUL3 STK38 CDC37 TMOD3 TXNL1 MSI2 CCT6A DBN1 SRRM1 ACTN1 HSP90AB1 DDX39B MYO6 TRA2B ACTG1 PHIP HNRNPC RBMX TWF1 CCT7 RHOBTB2 HSP90AA1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer SMAD2 SMAD3 FKBP1A TGFBR1 TGFBR2 TGFB1 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP CASP8 TNFSF10 FAS RIPK1 FADD TRADD TNFRSF10B FASLG TNFRSF10A TRAF2 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling APOA5 APOB APOE APOC3 LPL APOA2 APOC2 APOA1 GPIHBP1 APOA4 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein NUP62 RAN NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 RCC1 NUP50 NPM1 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 KPNB1 NUP35 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing PQBP1 EIF4A3 CASC3 MAGOH SRRT CDC40 SRRM1 SNRNP200 DDX39B SRSF2 SRSF3 SRSF4 CTNNBL1 SRSF5 HNRNPC SRSF6 SLU7 SRSF7 SRSF9 PRCC RBM8A SRSF1 U2AF1 U2AF1L4 U2AF2 CCAR1 DHX38 SRSF11 ALYREF UPF3B MAGOHB PCBP1 PCBP2 RNPS1 RBM10 DHX15 DHX16 WBP11 DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 U2SURP SNRPD2 SNRPD1 HNRNPF HNRNPA2B1 SNRPD3 SNRPA1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 CHERP PUF60 SNRPB2 AQR PRPF19 PTBP1 HNRNPH1 EFTUD2 HNRNPA1 HNRNPM HSPA8 SNRPG SNRPE SNRPF SNRPB DDX5 GTF2F1 GTF2F2 STEEP1 TCERG1 GPATCH1 PNN ZNF830 SF1 DHX8 PRKRIP1 CWF19L2 NCBP1 SNU13 NCBP2 HTATSF1 FUS WDR70 DHX35 ISY1 PRPF38A SMU1 BCAS2 NKAP UBL5 PRPF40A HNRNPA3 GCFC2 GPKOW PRPF18 CDC5L SDE2 FAM32A CACTIN PPP1R8 SRSF10 SRSF12 PRPF31 POLR2A SF3B1 RBMX2 POLR2B DHX9 SNIP1 POLR2C POLR2D IK PRP4K LENG1 POLR2G SUGP1 PRPF4 PRPF3 POLR2I SNRNP27 POLR2J SNRPC SNRPA SRSF8 ZMAT2 CCDC12 YJU2 LSM5 LSM4 LSM3 LSM2 PPIE LSM8 PPIH LSM7 PPIG LSM6 RBM25 PPWD1 DDX41 USP39 MTREX SART1 SNRNP70 TFIP11 SYF2 LUC7L3 HNRNPU C9orf78 NSRP1 HNRNPR WBP4 RNF113A RBM39 PPIL2 MFAP1 RBM42 ACIN1 HNRNPL HNRNPK BUD13 HNRNPD TRA2B FAM50A PHF5A TXNL4A SNRPN PLRG1 DNAJC8 PPIL1 SNRNP40 PPIL3 PPIL4 SRRM2 CRNKL1 SNW1 HNRNPH2 RBM7 CWC25 CWC27 CWC22 PRPF6 PRPF8 RBMX CWC15 RBM5 YBX1 POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation HGS PTPN12 ARHGEF7 STAM2 EREG SPRY2 BTC SH3KBP1 UBA52 HBEGF CDC42 CBL UBB EGF STAM AREG EGFR UBC EPS15 TGFA RPS27A PTPRK EPS15L1 EPGN EPN1 SH3GL2 SPRY1 PTPN3 SH3GL3 SH3GL1 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion GMPR CEACAM1 DIAPH1 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F2 KLKB1 SERPING1 F12 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRF3 TRAF3 LRRC14 TRAF6 USP14 IRF7 NLRC5 USP18 TIFA S100B SAA1 NOD1 NOD2 PTPN11 PPP2R1A BTRC UBE2D1 RELA SKP1 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD UBA52 TLR4 UBE2D2 TBK1 OPTN CUL1 UBB UBC RPS27A UBE2D3 DUSP4 DUSP3 RIPK3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 CHUK IKBKE IKBKB TP53 IKBKG RIPK2 MAPKAPK2 PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 MAPK3 MAP3K7 BIRC2 BIRC3 UBE2V1 TANK MAP2K6 IRAK1 IRAK2 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis ERLIN2 PSMA5 SEM1 PSMA6 PSMA3 DERL2 PSMC5 RNF5 PSMA4 PSMC6 OS9 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 RNF185 PSMC2 ERLEC1 UBA52 CFTR PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 SEL1L PSMB3 PSMD2 VCP PSMD3 DERL3 PSMB1 DERL1 PSMD1 ADRM1 ERLIN1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly CIAPIN1 NUBP1 ERCC2 NUBP2 ABCB7 NDOR1 CIAO3 CIAO1 RTEL1 BRIP1 POLD1 CIAO2B MMS19 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism PGK1 ENO1 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia NMRAL1 ASS1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 ITGB3BP H4C9 SMARCA5 HJURP RSF1 MIS18BP1 OIP5 CENPW H2AC20 MIS18A H2AX CENPA CENPC H2BC26 H2BC21 CENPT CENPU H2BC17 H2BC12 KNL1 H2BC13 H2BC14 CENPH H2BC15 CENPI H2AJ NPM1 H2BC11 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 H2BC1 CENPX RUVBL1 RBBP7 H2AC19 H2AB1 H2AZ2 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGFR3 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF2 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis CD3G FCGR3A SYK FGR HCK FYN FCGR1A FCGR2A PLCG2 AHCYL1 PLCG1 PRKX PRKACA CALM1 IL10 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 PRKAR2B V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 ITPR1 V1-11 ITPR2 IGKV2D-30 V1-16 V1-13 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A YES1 IGHG3 IGHG4 IGHG1 IGHG2 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA PAPSS2 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases H2AC14 PSMA5 INO80 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 HCFC1 TGFB1 UCHL5 YY1 USP15 NEDD8 BARD1 H2AC20 UCHL1 SENP8 UCHL3 OGT FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 BAP1 H2AC17 H2AC12 ACTL6A TGFBR1 TGFBR2 H2AC25 H2AC21 UBA52 PSMD12 PSMD11 UBB PSMD14 NFRKB PSMD13 UBC ACTR5 PSMA7 MCRS1 SMAD7 PSMB6 RPS27A KDM1B PSMD8 ACTR8 PSMB7 PSMB4 PSMD6 INO80C PSMB5 PSMD7 INO80B RUVBL1 INO80E PSMB2 INO80D PSMB3 PSMD2 PSMD3 PSMB1 H2AC19 PSMD1 H2AC1 TFPT ACTB ADRM1 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants SHC1 GAB1 CDC37 ERBIN EGF NRAS PIK3R1 ERBB2 PLCG1 EGFR NRG1 NRG2 EREG BTC PIK3CA NRG3 NRG4 HBEGF SOS1 HRAS HSP90AA1 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling IFNA16 JAK1 PTPN1 USP18 IFNA17 IFNA21 TYK2 IFNB1 STAT2 PTPN11 PTPN6 IFNA5 IFNA10 IFNA4 IFNAR1 IFNA7 SOCS1 IFNA6 IFNA1 IFNA2 IFNA8 IFNA14 SOCS3 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO SRC ROBO2 DCC ROBO1 SLIT2 NTN1 NELL2 SLIT1 SLIT3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors PRKCA AP2A1 GRIA1 GRIP1 GRIA2 TSPAN7 GRIA3 GRIA4 NSF GRIP2 PICK1 PRKCG PRKCB AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 HMMR YWHAE CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 TPX2 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 AURKA HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) SYT1 VAMP2 SYT2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding APP VAMP2 CLTB SNAP23 CLTC CLTA OCRL AP4E1 DNM2 ARRB1 CLINT1 M6PR AP1G1 FTH1 SH3GL2 AP1S2 AP1S1 AP1S3 AP3S1 HSPA8 CHMP2A SH3D19 STX4 AP4M1 TPD52 AP1G2 AP1B1 PIK3C2A AP3B1 DNASE2 VAMP8 CLVS2 GAK AP4S1 DNAJC6 CLVS1 FTL NAPA HGS RAB5C BLOC1S4 TGOLN2 BLOC1S6 SNX2 GNS BLOC1S1 BLOC1S3 SNX9 SNX5 AP1M2 TXNDC5 AP1M1 TBC1D8B SNAPIN SORT1 DTNBP1 HIP1R PUM1 CPD TPD52L1 AP4B1 IGF2R NECAP1 GOLGB1 VAMP7 YIPF6 CTSZ ACBD3 PICALM ARF1 GBF1 TFRC DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i ALG2 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis RXRA NR1H3 PCK1 NRIP1 RXRB PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 KCNIP3 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors MRTFA DYNC1LI1 DYNC1LI2 MYL6 DAAM1 MYL9 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 KIF2A NCKAP1L KIF2C KIF2B NOX3 CDC42 NOX1 ARPC1B ARPC1A CENPE NUF2 NUDC YWHAE DYNLL2 CIT PPP1CB INCENP PPP2R1A S100A9 S100A8 PKN3 CENPA CENPC YWHAG FLNA PPP1R12A CENPT CENPU IQGAP1 CFL1 DYNLL1 CKAP5 CENPF PAK2 ABI2 CENPH MAPRE1 CENPI TAOK1 ABI1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 GOPC PKN2 CENPN PKN1 CENPO CENPP CENPQ CENPS NCF1 NCF2 NCF4 CLASP1 DYNC1H1 NDE1 PLK1 CLIP1 PIK3R4 MAD1L1 LIN7B SFN DVL1 DVL2 DVL3 SRGAP2 ARPC4 ARPC5 NDC80 MYH9 RPS27 CTNNB1 ARPC2 CDH1 ARPC3 NOXA1 NF2 YWHAB BRK1 XPO1 SPDL1 NCK1 ACTR3 ACTR2 PRKCD PRKCA YWHAZ KLK2 EVL PPP1R12B ROCK2 SRF NSL1 MAPK14 MAPK11 WASF1 WASF2 WASF3 PPP1R14A BAIAP2 PRC1 MAPK1 KNL1 ZW10 MAPK3 BTK PFN1 CFTR ROPN1 PFN2 KLK3 MYL12B DSN1 SCAI RCC2 BUB1B CDC20 PTK2 ZWINT BUB3 AHCTF1 MAD2L1 KIF14 CDC25C RAC2 NDEL1 H2AC19 RHOG RHOC ACTB RHOD H2AC14 RHOB H2BC12L CTTN TAX1BP3 NUP107 RHOQ PIN1 MIS12 WAS NOXO1 PPP1CC YWHAQ PAK1 YWHAH PDPK1 CTNNA1 PAK3 DYNC1I1 H4C9 PIK3C3 NUP160 NUP85 BIRC5 H2AC20 B9D2 SPC24 AURKB SPC25 H2AX ERCC6L RTKN ZWILCH ACTG1 CALM1 H3-3B KNTC1 NCOA2 H3C8 CYBB CYBA SEC13 SGO1 SGO2 NUP133 RANGAP1 PMF1 H2AJ WASL NCKIPSD RHPN1 MYH14 MYH11 RHPN2 MYH10 H3C15 H2BC9 H2BC8 H2BC5 NUP43 H2BC3 DIAPH1 H2BC1 RANBP2 DIAPH3 DLG4 H2AB1 MEN1 NUP37 H2AC8 H2AC6 H2AC7 ITGB3BP AR BUB1 CLASP2 LIMK2 LIMK1 ABL1 FMNL3 FMNL1 KDM4C FMNL2 PPP2R5B PPP2R5A PPP2R5D ROCK1 PPP2R5C PPP2CA H2BC26 PPP2CB PPP2R1B H2BC21 PPP2R5E CDKN1B KDM1A RAC1 KIF5B KIF5A RHOA KTN1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ITGB1 H2BC11 KLC1 KLC4 KLC3 KLC2 CYFIP2 CYFIP1 KIF18A NCKAP1 WIPF1 WIPF2 WIPF3 MYLK PRKCB H2AZ2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family ERLIN2 CD274 PIK3R2 PIK3CB PIK3R1 MAP3K8 HIF1A MYC MYCN PIK3CA IRF1 PTPN6 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 CDC42 TNRC6A TNRC6B CCND1 PPP2R1A NEK2 BTRC DERL3 DERL1 RELA YWHAG SKP1 CTLA4 TCF7L2 NFKB1 JUND PAK2 ERLEC1 UBA52 CD4 AKT2 FOSB AKT3 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC LEF1 PSMA7 TRAC CD3E CD3D PSMB6 RPS27A BRD4 PSMD8 TRBV12-3 TRAV29DV5 PSMB7 TRBV7-9 TRBC1 PSMB4 PSMD6 HLA-DQA2 HLA-DQA1 PSMB5 PSMD7 HLA-DPA1 RPN2 PSMB2 PSMB3 TRAV19 PSMD2 HLA-DRB5 PSMD3 HLA-DRB4 RPN1 PSMB1 PSMD1 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 ADRM1 PSMA5 HLA-DQB2 STAT3 SEM1 HLA-DRB1 PSMA6 LYN PSMA3 HLA-DQB1 PSMC5 PSMA4 COPS5 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 PRKAB1 MAGT1 AKT1 JAK1 MAPKAP1 LCK PRKAG1 SPOP CSK PRKAG3 THEM4 FOS STAT1 RBX1 RICTOR ICOSLG TUSC3 PIK3CD PIK3CG TMEM258 PRKAB2 WWTR1 YES1 VCP H2AC19 YAP1 VAV1 H2AC14 CUL3 H2BC12L CD3G DERL2 OST4 RNF5 OS9 OSTC STT3A FYN RNF185 STT3B B3GNT3 PAK1 PRR5 PDPK1 CD28 DDOST DAD1 CREBBP PAK3 MLST8 H4C9 CD86 CD80 PRKAG2 H2AC20 PRKAA1 PTPN11 EZH2 H2AX ASH2L PIK3R3 MTOR PIK3R6 PIK3R5 TEAD1 H3-3B TEAD2 TEAD3 H3C8 TEAD4 ATF3 PDCD1LG2 GRAP2 MAP3K14 H2AJ PDCD1 H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 EP300 H2AC8 H2AC6 H2AC7 NFKB2 KMT2A KMT2C NFE2L2 BTLA TNFRSF14 CSNK2A1 GSK3B CSNK2A2 SEL1L DPY30 PPP2R5B PPP2R5A TCF7L1 PPP2R5D PPP2R5C CSNK2B JUN PPP2CA H2BC26 PPP2CB PPP2R1B H2BC21 PPP2R5E WDR5 PRKAA2 RAC1 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 MIB2 H2BC11 EPAS1 TCF7 CDK4 TRIB3 RBBP4 RBBP5 RBBP7 H2AZ2 ERLIN1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) DPP4 FFAR1 PAX6 SPCS3 SPCS2 SEC11A SPCS1 SEC11C GATA4 PCSK1 ISL1 GPR119 GIP TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 TNFSF11 PSMC6 PSMC3 PSMA1 PSMA2 NFKB2 PSMC4 PSMC1 PSMC2 CHUK TRAF3 TNF TNFRSF14 BTRC TNFSF13 TNFRSF18 UBA3 SKP1 UBE2M FBXW11 MAP3K14 TNFRSF6B EDA TNFRSF13B EDA2R TNFRSF8 TRAF2 TNFRSF4 EDARADD TNFRSF12A TNFRSF1B EDAR LTA TNFRSF25 LTB UBA52 TNFRSF1A TNFRSF11B TNFRSF11A TNFRSF17 TNFSF18 BIRC2 TNFSF14 BIRC3 TNFSF15 CD70 TNFSF12 TNFRSF13C TNFRSF9 CUL1 TNFSF6 TNFSF4 TNFSF9 PSMD12 CD27 PSMD11 UBB TNFSF8 LTBR PSMD14 RELB PSMD13 UBC CD40LG PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 TNFSF13B PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PAK2 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand APOB LBP TLR6 LY96 TLR1 GSDME S100A1 S100A9 GSDMD CD14 S100A8 TLR2 HMGB1 TLR4 TLR7 FGB FGA FGG CD36 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB104B DEFB1 DEFB136 DEFB109B DEFB135 DEFB134 DEFB133 DEFB132 DEFB108B CCR6 DEFB108C CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions ITGA1 NRP1 ITGB1 CNTN6 CHL1 ITGA2 HSPA8 ITGA10 ANK1 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF NTRK1 NGF CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes CREB3L2 CREBRF MBTPS2 CREB3 DCSTAMP CREB3L3 MBTPS1 CREB3L4 CREB3L1 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders SLC7A7 CP SLC7A9 NUP37 SLC24A1 SLC24A4 SLC4A1 SLC16A1 SLC4A4 HK1 SLC11A2 SLC22A5 NUP107 NUP188 BSG SLC3A2 AVPR1B NUP210 AVPR1A SLC5A7 NUP93 AVP SLC20A2 SLC39A4 SLC12A3 NUP205 SLC12A1 SLCO2A1 POM121 NUP214 SLC26A2 AAAS SLC26A4 SLC12A6 SLC26A3 AVPR2 SLC35A2 NUP160 SLC35A3 POM121C SLC33A1 SLC35C1 NUP85 TPR NUP88 NUP155 SLC29A3 SLC27A4 NUP153 GCKR GCK NUP62 SLCO1B1 SLC24A5 SLC22A12 SLCO1B3 NDC1 SEC13 SLC2A9 SLC2A1 NUP133 SLC2A2 NUP50 SLC5A5 NUP54 SLC34A3 SLC34A2 SLC34A1 SLC6A5 SLC6A2 SLC9A6 SLC40A1 SLC6A3 HEPH SLC9A9 NUP42 SLC2A10 SLC1A1 SLC1A3 SLC3A1 NUP43 SLC35A1 SLC6A20 SLC67A1 RAE1 RANBP2 RHAG SLC5A1 SLC6A19 SLC5A2 SLC17A8 SLC36A2 SLC17A5 NUP35 SLC6A14 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling RHOB MYL6 MET RRAS ERBB2 ARHGAP35 MYL9 RAC1 SEMA4D MYH9 RHOA ROCK2 PLXNB1 RND1 ARHGEF11 LIMK2 ROCK1 LIMK1 ARHGEF12 MYH14 MYH11 RHOC MYL12B MYH10 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis LPIN1 LPIN2 LPIN3 GPAT2 AGMO DGAT2 MOGAT3 MOGAT2 DGAT1 MOGAT1 GK3 GPAM GK2 GK SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin ALDH2 MAOA SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III LEMD2 TUBB2B TUBB2A TUBAL3 TUBA3E TUBB6 TUBA4A TUBB3 TUBA3D TUBB1 TUBA3C CHMP3 CHMP6 CHMP7 TUBA4B CHMP4C CHMP4B CHMP4A VPS4A TUBA1A TUBB8 SPAST IST1 TUBB8B CC2D1B TUBB4B TUBB4A CHMP2B TUBA8 CHMP2A TUBA1C TUBA1B DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex NCOR2 GPS2 TBL1X HDAC3 NCOR1 TBL1XR1 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A2 MAN1C1 MAN1A1 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 EP300 PSEN2 APH1A HDAC4 APH1B HIF1A HEYL ARRB2 MYC TBL1XR1 HDAC8 ADAM10 CREBBP PSENEN ADAM17 HDAC11 MAML2 PSEN1 CDK8 MAML1 HDAC5 NCSTN HDAC9 HDAC6 DLL4 ARRB1 MAML3 HDAC7 NEURL1 MIB1 SKP1 HDAC10 HEY1 JAG2 HEY2 SNW1 MAMLD1 DTX1 DTX2 DTX4 DNER NEURL1B DLK1 CNTN1 RBX1 NCOR2 KAT2B KAT2A NUMB UBA52 MIB2 NCOR1 TLE4 TLE2 CUL1 TLE1 HDAC2 TBL1X HDAC3 UBB NOTCH1 HDAC1 UBC RBPJ ITCH DLL1 RPS27A HES5 JAG1 NBEA HES1 CCNC AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer STAT3 ZAP70 TWIST1 RBX1 BCL2A1 MAPK1 ICOS DNMT1 MAPK3 PTPN6 TNRC6C ZC3HC1 MOV10 FOXM1 NPM1 AGO3 GZMB AGO4 AGO1 AGO2 IL10RA CUL1 CCNB1 PRF1 RPS6 JUNB HDAC1 IRF4 CEBPB RB1 STAT5A SKP1 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5C1A UPP2 AGXT2 UPP1 TYMP NT5C NT5E UPB1 DPYS NT5M DPYD MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle ACAT1 SIRT3 CS SDHAF2 SDHAF3 LYRM4 SDHAF1 SDHAF4 ISCA2 IDH2 ISCA1 SDHC SDHD SDHA CSKMT SDHB FXN ACO2 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects ADA APRT HPRT1 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation ELOA NELFB ELOB NELFCD NELFA ELOC NELFE CCNK CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F ELOA2 POLR2H SUPT5H CDK9 SSRP1 POLR2K POLR2L TCEA1 ELL RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway ALDH1A2 CYP26A1 RDH10 CYP26B1 RDH16 RDH14 RDH13 ALDH8A1 ADH1C ADH1A ADH4 CYP26C1 RDH11 AKR1C3 ALDH1A1 CRABP1 DHRS3 RDH5 DHRS4 ALDH1A3 SDR16C5 DHRS9 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching ROBO2 ROBO1 SLIT1 NCK2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling NRG3 SHC1 NRG4 NRAS HBEGF NRG1 SOS1 NRG2 HRAS EREG BTC TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CCNE1 TP53 ZNF385A CDKN1B PCBP4 CDK2 CCNA2 CCNA1 E2F7 E2F8 CDKN1A ARID3A E2F1 CCNE2 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 RAD9B RAD9A RPA1 HUS1 RPA2 EXO1 DNA2 RPA3 RHNO1 TOPBP1 RAD1 RFC5 RFC3 RFC4 RFC2 MRE11 ATRIP NBN BARD1 BRCA2 RAD51AP1 BRIP1 RAD17 RBBP8 ATM ATR BLM XRCC2 PALB2 RAD50 BRCA1 RAD51 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription NAB2 EP300 ATF1 LYL1 ELK1 ARC VGF TRIB1 TPH1 RRAD ASCL1 TCF12 EGR2 EGR3 EGR4 FOS FOSL1 ID2 ID3 SGK1 CDK5R2 ATF2 JUND ID1 EGR1 FOSB F3 REST JUNB CDK5 DNM2 SRF CHD4 CDK5R1 SH3GL3 MEF2D NAB1 ID4 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 NRAS ARHGAP35 BCAR1 RAC1 RHOA ELMO1 ELMO2 DOCK1 CRK HRAS PXN RASA1 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) MSH6 PCNA MSH2 PMS2 LIG1 RPA1 RPA2 MLH1 POLD3 EXO1 POLD1 POLD4 POLD2 RPA3 RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle VAV2 RHOB BCR PIK3R2 DAAM1 ARHGEF3 PIK3R1 CAV1 ARHGEF1 ARHGEF2 IQGAP3 ARHGEF5 ABR STARD13 STOM JUP MCAM SNAP23 ACTC1 ARHGAP1 CAVIN1 MYO9B MYO9A DLC1 CIT TJP2 ROCK2 RTKN VAMP3 PKN3 ARHGDIG ARHGAP39 ROCK1 ARHGAP5 ARHGAP21 FLOT2 PCDH7 ERBIN ARHGAP35 MCF2 OPHN1 ARHGEF25 ARHGEF28 VANGL1 DEPDC1B RHPN2 PKN2 ECT2 PKN1 RACGAP1 ARHGAP26 NET1 ANLN STK10 ARHGAP32 SLK DIAPH1 TFRC AKAP13 DIAPH3 SOWAHC ARHGEF10L MCF2L PREX1 FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 STARD8 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL LYN PIK3R2 SYK PIK3CB PIK3R1 HCK BLNK FYN RAPGEF1 CRKL PIK3CA YES1 CRK PIK3R3 PIK3CD CBL VAV1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions BTNL9 XDH BTNL8 BTN2A2 CD209 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 PPL DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation POLE4 POLE2 PRIM2 POLE PRIM1 POLE3 POLA1 POLA2 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID IKBKB IKBKG NFKB1 CHUK RELA NFKB2 NFKBIA REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death FLOT2 CDC37 RIPK3 TRADD MLKL PDCD6IP TNFRSF10B FASLG TNFRSF10A TRAF2 XIAP CASP8 TNFSF10 FAS RIPK1 FADD STUB1 UBA52 BIRC2 PELI1 BIRC3 UBB UBC PRKN ITCH RPS27A SDCBP OGT FLOT1 UBE2L3 HSP90AA1 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling STAT3 CA1 JAK2 TCP1 IL23R IL23A CDC42 PPIA RAP1B JAK1 CAPZA1 TYK2 CANX GSTO1 HSPA9 MTAP RALA PITPNA BOLA2B LMNB1 CNN2 HNRNPDL CFL1 STAT1 STAT4 IL12B GSTA2 IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 P4HB TALDO1 AIP ARF1 RPLP0 EBI3 IL27 IL6ST CRLF1 IL27RA NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway BRAF MAPK3 MAP2K1 MAP2K2 RAF1 MAPK1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade IRS1 PIK3R2 PIK3CB NRAS PIK3R1 THEM4 INS MAPK1 FRS2 MAPK3 PIK3CA FGF1 FGF4 INSR FLT3LG GRB10 FGF16 FGF9 PDPK1 FGF18 FGF20 SOS1 FGF23 TLR9 FLT3 AKT2 GAB2 FGF6 FGF2 PIK3C3 KLB SHC1 GAB1 FGF19 FGFR4 TRIB3 PTPN11 IRS2 FGF7 PDE3B FGF22 FGF3 FGF10 PIK3R4 HRAS LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome YWHAE CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism CYB5A SLC23A2 CYB5R3 GSTO2 GSTO1 SLC23A1 SLC2A1 SLC2A3 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 PLCG1 NTRK2 BDNF DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 GAB1 PIK3R1 PTPN11 FRS2 PIK3CA FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors HYOU1 SCARF1 APOB CALR HSPH1 HSP90AA1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST3GAL1 ST6GALNAC2 ST3GAL2 ST6GALNAC3 ST6GALNAC4 ST3GAL3 ST6GAL1 GALNT1 ST3GAL4 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism SLC52A2 SLC52A3 SLC52A1 ENPP1 FLAD1 RFK ACP5 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 TP53BP2 RABGGTB TP53I3 RABGGTA BCL6 BIRC5 PERP TP63 TP73 NDRG1 PPP1R13B BCL2L14 CHM ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism NT5C2 PCK1 ADH1A MAPDA DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling EBI3 STAT3 JAK1 IL6ST IL12RB2 IL27RA JAK2 CANX TYK2 STAT1 STAT4 IL12A INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells CDH1 SRC UBB CTNND1 UBA52 UBC CBLL1 RPS27A CTNNB1 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CCNE1 CDKN1B CDK4 CDK2 CCND3 CCND2 TFDP1 TFDP2 CDKN1C RB1 E2F2 CDKN1A E2F1 E2F3 CDK6 CCNE2 CCND1 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 B3GNT7 CHST1 B3GNT4 B3GNT3 CHST5 SLC35D2 B3GNT2 CHST2 CHST3 FMOD OGN KERA LUM OMD B4GALT1 ACAN B4GALT6 B4GAT1 B4GALT4 B4GALT5 PRELP CHST6 ST3GAL6 ST3GAL4 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors TUT7 TUT4 PABPN1 EIF4E EIF4A3 EIF4B PAIP1 DIS3L2 PABPC1 EIF4A2 EIF4A1 EIF4G1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 PHYH SLC25A17 SLC27A2 PECR RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle CCT2 CPSF7 CUL3 STK38 VIM RNF20 TXNL1 PDE5A COPS4 DBN1 SRRM1 COPS2 ROCK2 MYO6 TRA2B GPS1 SPEN HNRNPC RBMX ROCK1 CCT7 RHOBTB1 RBBP6 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin PSMA5 CDT1 CDC6 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SKP2 SKP1 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 RBX1 UBA52 CUL1 PSMD12 PSMD11 UBB PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ORC5 ORC4 ORC6 ORC1 ORC3 ADRM1 ORC2 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol NOP58 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C NOP56 UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 GAR1 DHX37 RRP36 UTP20 DCAF13 UTP6 NOP14 UTP4 UTP3 PNO1 KRR1 RCL1 TBL3 MPHOSPH10 NOL11 NOP10 RPS2 SNU13 RPS14 RPS9 RPS7 NOP2 RPS6 TRMT112 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB CALM1 PRKAR2A PRKAR2B PRKACG PRKACB NBEA ADCY9 PRKAR1B PRKAR1A PRKX ADCY4 PRKACA ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity EP300 PSMA5 SEM1 PSMA6 PSMA3 CDKN2A PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MDM2 UBA52 TGFB1 CBFB RUNX3 PSMD12 PSMD11 UBB PSMD14 PSMD13 SMURF2 UBC SMURF1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 SRC PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli NOX4 RPS6KA3 RPS6KA2 RPS6KA1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 ATP7A DDIT3 NOS3 SEC31A HBA2 VCL DEFA5 DCTN1 ATOX1 PSMD12 PSMD11 NOTCH1 PSMD14 PSMD13 RPLP1 PSMA7 RPLP0 PSMB6 PSMD8 UBE2D3 PSMB7 PSMB4 PSMD6 RPLP2 PSMB5 HSPA1B PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 BAG4 PSMD1 BAG2 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 SIRT3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 EXTL2 FOXO3 EXTL3 XPO1 KHSRP AKT1 FABP1 NUP214 DIS3 PRKCD MAPKAPK2 DCP2 RPL22L1 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 HSPA8 MAPK14 MAPK11 HSPA1A ITGA5 PRKACG PRKACB RBX1 ADCY9 PRKAR1B PRKAR1A COX4I1 ADCY4 COX4I2 ADCY3 PIK3CD ADCY2 ADCY1 ADCY8 ADCY7 ME1 ADCY6 ADCY5 PRKAR2A ARNT GNAS YAP1 CUL3 VEGFA NUP107 NUP188 NUP210 RPL23A NUP93 CAT NUP205 POM121 HSP90B1 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 HMGA1 NUP153 CSRP1 NUP62 SNCB ELOB ELOC NDC1 SEC13 NUP133 RPL27A NUP50 NUP54 CDKN2B NUP42 NUP43 RAE1 RANBP2 IGFBP1 NUP35 NUP37 G6PD CHUK HSPA5 EIF2AK3 CDK6 IKBKB GCLC IKBKG ATF6 CYCS GCLM FKBP5 CHD9 AMER1 PPP2R5B PPP2CA BLVRB PPP2R1B BLVRA STOML2 PHB2 MBTPS1 YME1L1 CITED2 MBTPS2 RPL26L1 RPL4 ITGB1 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL6 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 CAMK2B HSBP1 HSF1 CAMK2D RPL21 CAMK2A RPL23 RPL22 HSPD1 CAMK2G CRTC1 PIK3R2 RPL24 PIK3CB RPL27 RPL26 RPL29 RPL28 HIF1A MYC PIK3CA ID1 ITGB3 TNRC6C MOV10 AGO3 AGO4 RPL41 AGO1 RPL3L TNRC6A TNRC6B ADD1 CEBPB ANAPC15 ANAPC16 UBE2D1 ANAPC10 RELA ANAPC11 FZR1 CDC23 CDC26 CDC27 RPL10 RPL12 VENTX RPL11 ANAPC7 UBE2C RPL14 CDKN2A UBE2E1 RPL13 NFKB1 RPL15 IL6 RPL18 HSPA2 UBE2S RPL17 CDC16 RPL19 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RPS15 RPS14 GJA1 RPS17 RPS16 RPS19 RPS18 AKT2 AKT3 RPS11 RPS10 RPS13 RPS12 CACNB2 CACNB3 DNAJC3 RPS4Y2 PALB2 RPS4Y1 ASNS ALB RPS26 ATP6V1E1 RPS25 ATP6V1E2 RPS28 ATP6V1G1 RPS27 ATP6V0E1 RPS29 ATP6V1G2 RPL7A RPS20 RPS21 RPS24 GPX2 RPS23 GPX1 RPL37A ATP6V0D1 MAP1LC3B ATP6V0D2 ATP6V1A IKBKE RPL36A TXNRD1 RPL35A ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 SLC46A1 RPS27L RPS15A CHAC1 RPS3 TCIRG1 RPS2 STAT1 ATP6V0B COX7A2L IFNB1 ATP6V1B2 ATP6V0C ATP6V1B1 FAU P2RY2 RPS9 RPS7 RPS8 RPS5 RPS6 ATP6V0E2 ATP6V1G3 RPSA RPL39L VCP NLRP3 FYN GSK3A HSP90AB1 RPS4X PDPK1 RPS3A NQO1 BMAL1 VHL ABCG2 COX7A2 COX7A1 CRTC2 CRTC3 RAI1 HSPA9 CLEC1B MEF2D CALM1 ACADVL ABCC3 CCNE2 ABCC1 CCNE1 GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 PANX1 P2RX7 TXNIP GNG3 SKP2 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PDGFA MAFK AREG NFE2L2 PRKCI EEF1A1 TFDP1 TFDP2 E2F1 CACNB1 CACNA2D1 E2F3 JUN KEAP1 MAPK7 CDKN1B TRIM21 EPAS1 STAP2 PTPN1 PTK6 CDK4 CDK2 MAFG HBB CAPZB CXCL8 CUL7 CCL2 CUL2 CAPZA1 CAPZA2 EIF2S3 EIF2S2 EIF2S1 ATP6V1H TRPV4 LMNB1 LY96 ANXA2 TLR4 UBE2D2 SOD2 SOD1 FBXL17 BACH1 CHD6 SLC7A11 NFKBIA ATF2 KAT5 RRAGA RRAGC RRAGB RRAGD MAPKAP1 PRDX2 PRDX1 ATM ATR CDKN1A BRCA1 RPTOR FOS MAPK1 MAPK3 RICTOR RPA1 RPA2 RPA3 P4HB LAMTOR2 APOB LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CCNA2 CCNA1 MRE11 SESN2 MT-CO1 NBN CAPZA3 ACTR10 ZBTB17 MAPKAPK5 SLC38A9 DCTN6 DCTN5 DCTN4 MAP2K6 MT-CO2 MT-CO3 CLOCK ACD RHEB TINF2 TERF1 TERF2 POT1 MDM2 HSPB8 TERF2IP HIKESHI MDM4 CCAR2 DNAJC2 SULT1A3 DNAJC7 CRYAB PRR5 RPS19BP1 HSPA4L HSPA14 HSPA13 DNAJB1 HSPH1 SQSTM1 BAG5 DNAJB6 MLST8 BAG3 BAG1 HSPA1L HSPA4 ST13 HSPA7 HSPA6 HSPA12A HSPA12B IL1A MTOR RAD50 ATF3 HIRA GSTP1 CREB3 DCSTAMP CREB3L3 CREB3L4 CREB3L1 CREB3L2 CREBRF NRF1 NPAS2 EP400 RORA NR3C1 ESR1 NR3C2 AR KDM6B RXRA SP1 PGR PPARA TP53 CSNK2A1 CSNK2A2 CSNK2B ATF5 SAMTOR NPRL2 PRKAA2 NPRL3 EIF2AK1 EIF2AK4 H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 NOX5 EXTL1 EGLN1 EGLN3 EGLN2 CASTOR1 WTIP CASTOR2 ERO1A SESN1 MAP3K5 MUL1 FLT4 ARFGAP1 IMPACT HM13 SH3BP4 MT1M NUDT2 MT1X MT2A TALDO1 PIEZO1 MT1A MT1F MT1G PREB TRIB3 MT1H KDELR3 MT1B MT1E OMA1 PLA2G4B DELE1 FKBP14 HERPUD1 MYDGF ATF4 MINK1 DEPDC5 RAMP2 YIF1A HDGF NPLOC4 ETS2 UFD1 ERN1 HTRA2 CACNA1H GCN1 HMGA2 MT4 MT3 CABIN1 GOSR2 KICS2 DYNC1LI1 SOD3 DYNC1LI2 CCS TSPYL2 DDX11 ASF1A SEH1L PRDX3 SSR1 WDR59 PRDX6 ADM HIF3A MIOS WDR24 UBN1 CDKN2D COX7B CDKN2C EPO CDH5 ERF TNIK COX7C CALCRL IGFBP7 WFS1 TPP1 ITGAV SRXN1 HIF1AN GPX3 COX8A GPX6 GPX5 COX8C GPX8 GPX7 WIPI1 CTDSP2 EGF PECAM1 CEBPG CACNG7 PPP1R15A DNAJB9 YWHAE FNIP1 FNIP2 DYNLL2 TXNRD2 COX5B DNAJA1 DNAJA4 COX5A PPP2R2A ACTR1A LONP1 LIMD1 SERP1 PPP2R1A UBXN7 ITFG2 KPTN MAP4K4 BTRC TATDN2 PRKACA SZT2 PDIA6 PDIA5 COX6C DPP3 KLHDC3 SKP1 SRPRA SRPRB FLCN HSP90AA1 ATF6B ABCF2 COX6A1 COX6A2 TXN2 DYNLL1 FKBP4 UBA52 AJUBA COX6B2 NRIP1 COX6B1 DYNC1I2 PKN2 DCTN2 DCTN3 CUL1 SHC1 UBB NCF1 PRKAR2B NCF2 UBC NCF4 HIGD1A HIGD1C RPS27A DYNC1H1 STIP1 STAT3 BCL2 BCL2L1 CA9 CAPNS1 CAPNS2 CAPN2 GRB10 TGS1 HSPG2 CARM1 HMOX1 HMOX2 NR1D1 MMP14 PTK2 SPP1 MTF1 TKT RB1 EHMT2 H2AC19 EHMT1 H2AC14 EDEM1 H2BC12L SYVN1 MED1 RPL10L RPL10A PGRMC2 PPARGC1A CREBBP DYNC1I1 PGD H4C9 AKT1S1 H2AC20 EZH2 H2AX HYOU1 H3-3B NCOA1 NCOA2 H3C8 CYBB CYBA NCOA6 APOA1 RPL13A SIRT1 NCOR2 H2AJ E2F2 NCOR1 KDR H3C15 TBL1X SUZ12 H2BC9 H2BC8 CALR H2BC5 H2BC3 H2BC1 DNAJB11 RPL18A RPL36AL H2AB1 EP300 H2AC8 H2AC6 H2AC7 TBL1XR1 TXN HELZ2 HSPE1 ABL1 BMI1 ETS1 RING1 RNF2 HDAC6 GSK3B DNAJA2 CBX8 PHC2 CBX6 PHC1 H2BC26 TLN1 CBX4 CBX2 SIN3A H2BC21 NFYA PHC3 NFYB NFYC PTGES3 GFPT1 EED LMNA GSTA3 H2BC17 GSTA1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RPL9P9 COXFA4 HDAC3 SMARCD3 CXXC1 H3-4 RBBP4 AQP8 IDH1 RBBP7 H2AZ2 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME UGT2B7 CYP2C19 UGT1A1 ALB UGT2B28 SLC16A1 BCHE BSG UGT1A5 UGT1A3 UGT1A9 ABCC3 ABCC2 UGT1A8 GLYATL3 UGT1A4 UGT1A7 GLYATL2 UGT1A6 GLYATL1 CYP2C9 CYP2C8 CYP2D6 GLYAT ACSM2A CYP2E1 CYP3A4 CES2 ACSM2B CES1 UGT2A3 UGT2A2 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B4 ACSM5 ACSM4 UGT3A2 UGT3A1 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters KMT2A CLOCK BMAL1 CREBBP SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease NRAS PIK3R1 NCBP1 NCBP2 FRS2 PIK3CA FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 GTF2F1 SOS1 FGF23 GTF2F2 FGF6 FGF2 FGFR2 POLR2A GAB1 POLR2B POLR2C POLR2D PLCG1 POLR2G POLR2I POLR2J FGF7 POLR2E POLR2F POLR2H FGF22 FGF3 FGF10 POLR2K POLR2L HRAS SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 NUP107 KIF2A MIS12 PPP1CC PTTG1 KIF2C KIF2B DYNC1I1 CENPE NUF2 NUDC NUP160 NUP85 DYNLL2 BIRC5 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L ZWILCH ANAPC15 ANAPC16 CENPA UBE2D1 ANAPC10 CENPC ANAPC11 CDC23 CDC26 CDC27 CDCA5 KNTC1 ANAPC7 PDS5B PDS5A UBE2C WAPL UBE2E1 ESPL1 CENPT CENPU UBE2S CDC16 SGO1 ANAPC4 SEC13 SGO2 ANAPC5 SMC3 ANAPC1 ANAPC2 NUP133 DYNLL1 RAD21 CKAP5 CENPF STAG1 STAG2 CENPH RANGAP1 PMF1 SMC1A MAPRE1 CENPI UBA52 TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CENPP CENPQ PSMD12 CENPS PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 NUP43 PSMB6 RPS27A PSMD8 CLASP1 PSMB7 RANBP2 PSMB4 PSMD6 DYNC1H1 PSMB5 PSMD7 PSMB2 NDE1 PLK1 PSMB3 PSMD2 CLIP1 PSMD3 PSMB1 PSMD1 MAD1L1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 NUP37 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 ITGB3BP PSMC4 NDC80 PSMC1 RPS27 PSMC2 BUB1 CLASP2 XPO1 SPDL1 NSL1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E KNL1 ZW10 DSN1 BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 KIF18A NDEL1 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs CAPZB DYNC1LI1 DYNC1LI2 PTGES3 HSPA2 NR3C1 DYNLL1 FKBP4 DCTN1 NR3C2 HSP90AB1 AR DYNC1I2 DNAJB1 PGR DCTN2 DCTN3 DYNC1I1 HSPA1L CAPZA1 CAPZA2 FKBP5 DYNLL2 CAPZA3 DNAJA1 ACTR10 DNAJA4 ACTR1A DYNC1H1 DNAJA2 HSPA1B DCTN6 HSPA8 DCTN5 DCTN4 HSPA1A STIP1 HSP90AA1 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines H2AC12 H2AC14 H3C8 PRMT5 WDR5 JAK2 H2AC8 WDR77 RPS2 H2AC6 H2AC7 ACTL6A COPRS SMARCC1 SMARCC2 DNMT3A ARID1A ARID1B H2AC25 H2AC21 H2AJ PRMT6 PBRM1 PRMT7 ACTL6B PRMT3 CCND1 SMARCD1 H4C9 H3C15 SMARCD2 SMARCD3 PRMT1 CDK4 SMARCA2 SMARCA4 H2AC20 CARM1 H2AX SMARCB1 RBBP7 ARID2 H2AC19 H2AC1 H2AB1 SMARCE1 H2AZ2 H2AC17 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells NRAS RASGRP3 RASGRP1 HRAS APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins CDH1 DSG3 TJP2 DSP CASP3 DSG1 DSG2 PKP1 OCLN CTNNB1 TJP1 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response H2BC12L UBE2N MAPK8 UBE2V2 H4C9 SMARCA5 H2AX BAP1 RAD50 PHF6 DCAF8L1 DCAF8L2 BRCC3 PPP5C BABAM1 BABAM2 UIMC1 BAZ1B ABRAXAS1 RNF8 APBB1 EYA2 EYA3 EYA4 UBA52 PSMD12 PSMD11 UBB NSD2 PSMD14 PSMD13 UBC H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 DDB1 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 TP53BP1 PSMA5 SEM1 CUL4A PSMA6 PSMA3 PSMC5 PIAS4 PSMA4 PSMC6 RNF168 PSMC3 UBE2I PSMA1 PSMA2 PSMC4 PSMC1 CUL4B MDC1 PSMC2 KAT5 CHEK2 UBXN1 SUMO1 ABL1 KDM4A KDM4B TP53 BARD1 ATM BRCA1 H2BC26 H2BC21 HERC2 RBX1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 KPNA2 MRE11 H3-4 NBN EYA1 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation ITPR1 NFATC1 CALM1 ITPR2 AHCYL1 NFATC3 ITPR3 PPP3CA PPP3CB PPP3R1 NFATC2 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage XIAP CASP3 APAF1 CASP9 CYCS CASP7 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited CASP8 TNFSF10 FAS RIPK1 FADD TRADD TNFRSF10B FASLG TNFRSF10A TRAF2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 CASP8 TNFSF10 FAS RIPK1 FADD TRADD TNFRSF10B FASLG TNFRSF10A TRAF2 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis CALM1 SLC8A1 SLC8A2 P2RX7 P2RX6 P2RX5 STIM1 P2RX3 P2RX2 P2RX1 ORAI2 ORAI1 ITPR1 ITPR2 P2RX4 ITPR3 TRPC7 SLC8A3 ATP2B4 ATP2A3 ATP2A2 TRPC6 TRPC3 ATP2B3 ATP2A1 ATP2B2 ATP2B1 SRI SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins RANGAP1 SUMO1 UBE2I GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER POLE4 POLE2 POLE3 PCNA UBA52 LIG1 RPA1 RPA2 POLD1 RPA3 RFC5 UBB RFC3 RFC4 POLK RFC2 UBC POLE RFC1 RPS27A LIG3 POLD3 POLD4 POLD2 XRCC1 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport PSMA5 ERLIN2 SEM1 PSMA6 PSMA3 DERL2 PSMC5 PSMA4 RNF5 PSMC6 OS9 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 RNF185 PSMC2 ABCG8 ABCG5 KCNJ11 ABCA6 ABCD1 ABCC6 ABCC9 SEL1L DERL3 DERL1 EIF2S3 ABCG1 EIF2S2 EIF2S1 ABCB7 ABCB4 ABCD3 APOA1 ERLEC1 UBA52 CFTR ABCA12 ABCD2 ABCC10 ABCC3 ABCC11 ABCC1 ABCB1 ABCC4 ABCC2 ABCA10 PEX3 ABCC5 ABCG4 PSMD12 PSMD11 ABCB5 UBB ABCB8 PSMD14 ABCB9 PSMD13 ABCF1 UBC ABCA2 ABCA5 ABCA9 PSMA7 ABCA7 ABCA8 PSMB6 RPS27A ABCB10 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PEX19 PSMD7 PSMB2 PSMB3 PSMD2 ABCB6 PSMD3 VCP PSMB1 PSMD1 ABCA3 ABCA4 ADRM1 ERLIN1 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry GPC1 RAB5B RAB5C GPC3 CX3CR1 FURIN GPC2 GPC5 EGFR GPC4 LY96 GPC6 SDC1 SDC4 CD14 AGRN IGF1R TLR4 SDC2 NCL SDC3 RAB5A HSPG2 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease XRN1 DCP2 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DCP1A RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants KRAS NRAS HRAS RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs CALM1 FLNA PPP1R12A CTTN MYL6 MYL9 RAC1 MYH9 PPP1CB PPP1R12B PAK2 NF2 MYLK PAK1 CDC42 LIMK1 MYH14 MYH11 PAK3 MYL12B MYH10 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias ABCC8 KCNJ11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD MMACHC MMADHC CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) NLRP3 NFKB1 CTSG MEFV C3 NFKB2 P2RX7 PYCARD PSTPIP1 CASP1 HMOX1 TXNIP HSP90AB1 TXN SUGT1 ENTPD1 C3AR1 ENTPD5 IL18 IL1A IL1B P2RX4 GSDMD NT5E RELA SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA AGPAT1 AGPAT2 PLA2R1 AGPAT3 AGPAT4 GPAT4 GPAT3 GPAT2 PLD6 PLA2G5 PLA2G2F PLD1 PLA2G2D PLD2 PLA2G2E PLA2G2A DDHD2 DDHD1 GPAM LPCAT4 ALPI GPD1L LPCAT1 ACP6 LCLAT1 PLA2G12A LIPI LIPH PLA2G4D PLA2G4B MIGA2 PLA2G4A MIGA1 GNPAT GPD2 AGPAT5 GPD1 PLA2G10 PLA2G1B CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation YWHAE CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 TUBG2 MZT2B HAUS8 MZT2A PRKAR2B NME7 HAUS7 TUBGCP2 CEP70 MZT1 CEP72 TUBGCP5 CEP192 TUBGCP6 PCNT TUBGCP3 TUBGCP4 CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CDK11A CEP152 NDE1 CDK11B PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm TCF7L2 CXCR4 SMAD2 SMAD4 SMAD3 EOMES CTNNB1 TBXT CDH1 GSC MIXL1 FOXA2 GATA6 SOX17 GATA4 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se HNMT AHCY SCLY MAT1A GNMT CBS CTH NNMT ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors ADCYAP1 NTRK2 ADCYAP1R1 ADORA2A NTRK1 NGF TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants FLT3 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K VKORC1 UBIAD1 VKORC1L1 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib CDC37 ERBIN ERBB2 HSP90AA1 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels OPRK1 PTPN1 HDAC2 MET GRIN2A HDAC1 FKBP5 GRIN2B SLC2A3 GPRIN1 GRIA2 OPRM1 PTPN4 TRPC3 SIN3A DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SLC35D1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol HSD3B7 NCOA1 NCOA2 CYP7B1 NR1H4 AKR1D1 CYP27A1 AKR1C1 CYP7A1 AKR1C3 AKR1C2 RXRA AKR1C4 CYP8B1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts NCOA1 NCOA2 NR1H4 CYP27A1 ABCD3 ACOX2 RXRA ABCB11 HSD3B7 OSBPL1A CYP7B1 CYP39A1 HSD17B4 AKR1D1 OSBPL9 OSBPL7 OSBPL6 CYP7A1 AKR1C1 OSBPL3 OSBPL2 BAAT AKR1C3 OSBP ACOT8 AKR1C2 AKR1C4 CYP8B1 CH25H AMACR SLC27A2 SLC27A5 CYP46A1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) KCNK9 KCNK3 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation LTF DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 GAB1 NRAS PIK3R1 PLCG1 PTPN11 FRS2 PIK3CA FGF1 FRS3 FGF4 FGF22 FGF3 FGF9 FGF10 FGF20 SOS1 FLRT2 FGF23 FLRT3 HRAS FLRT1 FGF6 FGF2 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils LOXL3 LOXL4 BMP1 TLL2 TLL1 PXDN LOXL1 LOXL2 PCOLCE LOX PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) ADRA2B SYK RAP1A RAPGEF3 ITGB3 RAPGEF4 GP1BA APBB1IP CRK PDPK1 ADRA2C ADRA2A SOS1 FGB FGA GP1BB FGG RAP1B F2 AKT1 SHC1 PTPN1 PTK2 BCAR1 VWF ITGA2B GP5 GP9 SRC RASGRP2 RASGRP1 CSK TLN1 MPL THPO FN1 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R NRAS IGF1R IGF2 IGF1 SOS1 HRAS SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA CDT1 CDC6 LIG1 RFC5 RFC3 RFC4 RFC2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 FEN1 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 CCNE2 CCNE1 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC POLE RFC1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 POLD3 POLD4 POLD2 ADRM1 PSMA5 SEM1 PSMA6 POLE4 PSMA3 PSMC5 PSMA4 PSMC6 POLE2 PRIM2 PSMC3 PSMA1 PRIM1 POLE3 PSMA2 POLA1 PSMC4 POLA2 PSMC1 PSMC2 SKP2 POLD1 DNA2 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 RBX1 PCNA RPA1 RPA2 RPA3 CDK2 CCNA2 CCNA1 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2AC14 H2BC21 H3-3B H2BC12L NCOA2 H3C8 KDM1A H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 AR H2AJ H2BC11 KLK3 KDM4C PKN1 H4C9 H3C15 H2BC9 KLK2 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX H2AC19 H2BC26 H2AB1 H2AZ2 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH PSEN2 APH1A APH1B HIF1A HEYL MDK MYC TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B CCND1 PSENEN RUNX1 EGF EGFR MIB1 SKP1 HEY1 HEY2 WWP2 UBA52 CUL1 PSMD12 PLXND1 PSMD11 UBB NOTCH1 PSMD14 PSMD13 UBC RBPJ DLL1 PSMA7 PSMB6 RPS27A PSMD8 LFNG PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ST3GAL4 ADRM1 PSMA5 PBX1 SEM1 DLGAP5 PSMA6 ST3GAL3 FCER2 PSMA3 PSMC5 TACC3 PSMA4 WWC1 PSMC6 PTCRA ACTA2 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 GZMB ADAM10 ADAM17 AKT1 YWHAZ PSEN1 FABP7 NCSTN DLL4 ELANE NEURL1 DTX1 DTX2 DTX4 DNER DLK1 CNTN1 STAT1 RBX1 NUMB FURIN ITCH H2AC19 CCNC H2AC14 H2BC12L CREBBP H4C9 H2AC20 ARRB1 H2AX ATP2A3 ATP2A2 ATP2A1 HDAC10 JAG2 H3-3B H3C8 NEURL1B NCOR2 KAT2B KAT2A H2AJ NCOR1 H3C15 TBL1X H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 NBEA H2AB1 EP300 H2AC8 HDAC4 H2AC6 H2AC7 ARRB2 TBL1XR1 HDAC8 HDAC11 TP53 B4GALT1 POGLUT1 MAML2 CDK8 MAML1 POFUT1 TMED2 PRKCI SIRT6 HDAC5 TFDP1 TFDP2 HDAC9 ELF3 MFNG HDAC6 MAML3 HDAC7 NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 ST3GAL6 E2F3 RAB6A JUN H2BC26 NOTCH2NLA NOTCH2NLC NOTCH2NLB SNW1 MAMLD1 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 MIB2 H2BC11 FLT4 TLE4 TLE2 TLE1 HDAC2 HDAC3 SMAD3 HDAC1 HES5 JAG1 YBX1 HES1 H2AZ2 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD TBXAS1 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA LINGO1 MCF2 MAG OMG NGFR RHOA RTN4 NGF INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling STAT3 JAK1 STAT5A STAT5B IL2RG STAT1 STAT4 IL21 IL21R JAK3 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions CASK NCK1 PIK3R2 SPTBN1 PIK3CB PIK3R1 FYN IQGAP1 KIRREL3 KIRREL1 ACTN1 KIRREL2 ACTN3 PIK3CA MAGI2 ACTN4 CD2AP NPHS1 SPTAN1 WASL NCK2 ACTN2 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud HOXA11 WNT11 SALL1 SIX2 SLIT2 EYA1 GFRA1 NPNT ROBO2 ITGB1 PAX2 RET BMP4 FOXC2 GREM1 FOXC1 GDNF SIX1 HOXD11 ITGA8 HOXC11 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA ACADS HADHB HADHA HADH ECHS1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin LEP PLA2G7 CRHR2 IGF1 MBOAT4 INS BCHE SPCS3 SPCS2 SEC11A SPCS1 SEC11C GH1 UCN GCG PCSK1 KLF4 ACHE NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation FBXO21 FBXO22 HIF1A FBXW12 FBXW8 FBXO17 HIF3A FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 CUL7 CUL5 CUL2 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F NEDD8 LRRC41 KLHL25 ZBTB16 KLHL21 KLHL22 UBXN7 BTBD6 FBXO30 KLHL20 FBXO31 BTRC GPS1 UBE2D1 DPP3 UBA3 SKP1 UBE2M FBXW11 KBTBD13 ASB13 ASB14 ASB11 UBA52 ASB12 UBE2D2 RNF7 ASB17 ASB18 FBXL22 ASB15 FBXL21P ASB16 CUL1 FBXL20 PSMD12 PSMD11 UBB PSMD14 ASB10 PSMD13 UBC FBXL19 FBXL18 PSMA7 FBXL15 FBXL16 PSMB6 RPS27A FBXL13 PSMD8 UBE2D3 FBXL14 FBXL12 PSMB7 PSMB4 ASB8 PSMD6 DDB1 ASB9 PSMB5 PSMD7 ASB6 PSMB2 ASB7 PSMB3 PSMD2 ASB4 PSMD3 COPS7B PALB2 COPS7A PSMB1 ASB5 PSMD1 ASB2 ASB3 ASB1 ADRM1 PSMA5 SEM1 CUL4A PSMA6 PSMA3 COPS3 PSMC5 COPS6 PSMA4 COPS5 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 COPS8 PSMC1 CUL4B PSMC2 COPS4 COPS2 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 COMMD9 PUM2 DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 COMMD7 COMMD4 FBXO32 COMMD5 SPSB3 CCDC8 CUL9 UBD NAE1 SOCS6 WDTC1 SOCS5 CCDC22 CDKN1A COMMD10 DTL TULP4 DCAF16 DCAF17 BRCA1 CAND1 FEM1C DCAF10 DCAF11 FEM1A FEM1B NEURL2 ERCC8 DDB2 RBX1 VCP CUL3 KBTBD7 SQSTM1 VHL BIRC5 SENP8 UCHL3 ELOB ELOC DCAF7 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 CISH FBXL3 SOCS2 FBXL5 SKP2 COP1 NFE2L2 AMER1 DCAF13 LRR1 CCNF KEAP1 WDR5 FBXO7 FBXO9 WSB1 FBXO2 MUL1 EPAS1 FBXL8 FBXL4 SOCS3 FBXL7 KCTD6 GAN KLHL2 KLHL3 RBBP5 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NPLOC4 RBBP7 UFD1 KBTBD8 SPSB4 FBXO27 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 STAT3 STAP2 PTK6 SOCS3 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria KHK LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production GGT1 DPEP2 DPEP1 GGT5 CYSLTR1 CYSLTR2 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins ACOT2 OST4 OSTC UBE2I STT3A KPNA7 KPNA4 KPNA5 STT3B KPNA3 KPNA1 SUMO1 HSPA5 DDOST MAGT1 DAD1 IPO7 XPO1 PDIA3 DPM1 DPM2 DPM3 DNAJC10 SEC11A SEC11C CANX KPNB1 NMT1 PRKG2 HYOU1 APOA1 SPCS3 SPCS2 SPCS1 UBA52 TUSC3 KPNA2 P4HB UBB SCAP UBC TMEM258 CALR DNAJC3 P4HA1 RPS27A P4HA2 P4HA3 RPN2 DNAJB11 RPN1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B COX7B COX7C MT-ATP6 ETFDH COX8A OGDH COX8C MT-ND6 MT-ND4 MT-ND5 MT-ND2 TMEM186 MT-ND3 MT-ND1 COX5B COX5A TIMM21 TMEM177 COX6C MT-ATP8 UQCRC1 UQCRC2 NDUFAB1 TACO1 COX6A1 COX6A2 TIMMDC1 SDHC SDHD UBA52 SDHA COX6B2 SDHB COX6B1 COX19 MAEA NDUFB10 COX16 COX15 NDUFB11 CS COX18 UBB COX17 UBC HIGD1A GLO1 HIGD1C RPS27A ECSIT COX11 COX14 PDHA2 PDHA1 HIGD2A SIRT4 COX20 TMEM223 SIRT3 DLD FH DMAC1 DMAC2 UCP1 PET117 PC UCP3 UCP2 PET100 MDH1 MDH2 LETM1 FAHD1 LYRM2 LYRM4 LYRM7 TTC19 ARMC8 ACAT1 CMC1 GOT1 LDHC COX7A2L GOT2 VDAC1 LDHB LDHA COX4I1 COX4I2 ME1 ME3 ME2 NDUFC2 NDUFC1 GPT SLC25A18 MT-CO1 TRAP1 RAB5IF SLC25A12 SLC25A4 COQ10B SLC25A11 COQ10A SLC25A14 SLC25A13 NDUFB9 HCCS NDUFB8 NDUFB7 WDR26 NDUFB6 NDUFB5 NDUFB4 NNT NDUFB3 SCO1 NDUFB2 NDUFB1 SCO2 TMEM126A MT-CO2 DLAT MT-CO3 PDK4 TMEM126B SLC25A27 D2HGDH MKLN1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 MPC1 NDUFA6 MPC2 UQCR11 NDUFA3 UQCR10 NDUFA2 NDUFA1 ATP5F1A ATP5F1B SFXN4 RANBP9 ATP5F1C ATP5F1D ATP5F1E MPC1L COA3 COA1 OXA1L COX7A2 COX7A1 HSPA9 IDH3B SDHAF2 IDH3A COA5 SDHAF3 SURF1 SDHAF1 ADHFE1 SDHAF4 L2HGDH HSCB PDHB DLST GID4 GID8 IDH3G ACAD9 NEK1 NUBPL ISCA2 ISCA1 RMND5B RMND5A KGD4 PDK3 UQCRB PDK2 PDK1 PDHX UQCRH SUCLG2 ATP5MC2 SUCLG1 ATP5MC3 ATP5MC1 CYC1 NDUFV3 NDUFV2 UQCRQ PM20D1 NDUFV1 ACO2 MT-CYB CYCS ETFA ETFB UQCRFS1 PDPR NDUFS8 NDUFS7 NDUFS6 NDUFS5 FXN ATP5PF SMIM20 NDUFS4 ATP5PD NDUFS3 NDUFS2 ATP5PB NDUFS1 PDP1 FOXRED1 PDP2 UQCRHL ATP5PO NDUFA13 NDUFA11 NDUFA12 GSTZ1 SUCLA2 NDUFA10 CSKMT COXFA4 BCS1L ATP5MK ATP5MJ PYURF ATP5MG ATP5MF ATP5ME UQCC3 UQCC2 UQCC1 IDH2 UQCC6 UQCC5 DMAC2L DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome CASP1 NLRC4 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes GOSR2 EDEM1 HYOU1 SYVN1 TSPYL2 DDX11 GFPT1 SSR1 ACADVL LMNA GSK3A DCTN1 EXTL2 EXTL1 SULT1A3 CUL7 EXTL3 WFS1 TPP1 ATP6V0D1 ARFGAP1 ADD1 SHC1 WIPI1 CTDSP2 CXXC1 DNAJB9 PREB DNAJC3 KDELR3 PLA2G4B FKBP14 SEC31A SERP1 ZBTB17 MYDGF TATDN2 YIF1A HDGF PPP2R5B PDIA6 PDIA5 DNAJB11 KLHDC3 SRPRA SRPRB TLN1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRF3 TRAF3 LRRC14 TRAF6 USP14 IRF7 NLRC5 USP18 TIFA S100B SAA1 NOD1 NOD2 PPP2R1A BTRC UBE2D1 RELA SKP1 TLR3 FBXW11 NFKB1 TRAF2 TICAM1 CASP8 RIPK1 FADD UBA52 UBE2D2 TBK1 OPTN CUL1 UBB UBC RPS27A UBE2D3 DUSP4 DUSP3 RIPK3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 CHUK IKBKE IKBKB TP53 IKBKG RIPK2 MAPKAPK2 PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 MAPK3 MAP3K7 BIRC2 BIRC3 UBE2V1 TANK MAP2K6 IRAK1 IRAK2 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes PCSK5 FURIN LMF2 LMF1 LIPC ANGPTL8 ANGPTL3 FGF21 CREB3L3 APOC2 MBTPS1 APOA4 APOA5 MBTPS2 PCSK6 LPL GPIHBP1 ANGPTL4 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l ALG9 DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair OGG1 NTHL1 NEIL3 NEIL1 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE ABCC6 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants KIT PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 KLB GAB1 PIK3R1 FGF19 FGFR4 PTPN11 FRS2 PIK3CA FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF6 FGF2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination CRCP SSB NFIX POLR3GL POLR3A NFIA POLR3B NFIB POLR3C NFIC POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H POLR3K POLR2H POLR1C POLR1D POLR2K POLR2L SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism SDS SDSL SERINC1 SERINC3 PSPH SRR PSAT1 SERINC2 SERINC5 SERINC4 PHGDH G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription CDT1 CDC6 E2F5 E2F6 POLA1 PCNA LIN54 LIN37 LIN9 LIN52 DHFR CCNE1 RRM2 FBXO5 HDAC1 CCNA1 RBL2 RBL1 TK1 RBBP4 TYMS TFDP1 TFDP2 E2F4 E2F1 CDK1 ORC1 CDC45 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation HGF MET HGFAC SPINT1 HPN SPINT2 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 FGFR1 FGF1 FGF4 FGF9 FGF20 FGF23 FGF6 FGF2 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis ESRRA CRTC1 NRF1 SIRT3 MED1 ATP5MC2 MEF2C ATP5MC3 ATF2 TBL1XR1 ATP5MC1 HCFC1 HELZ2 RXRA PRKAB1 SAMM50 MT-ATP6 PPARGC1A ATP5F1A PPARGC1B PPARA ATP5F1B GLUD1 TGS1 GLUD2 CREBBP ACSS2 ATP5F1C ALAS1 MTX1 ATP5F1D CYCS ATP5F1E CHD9 PRKAG2 CARM1 MAPK12 CRTC2 PRKAG1 CRTC3 MAPK14 HSPA9 MT-ATP8 MAPK11 PRKAG3 MEF2D ATP5PF ATP5PD CALM1 NCOA1 MICOS13 NCOA2 ATP5PB MICOS10 MTERF1 PRKAA2 NCOA6 TFAM APOO APOOL TFB1M GABPA TFB2M ATP5PO PPRC1 MTX2 CHCHD3 CHCHD6 NR1D1 POLRMT NCOR1 SOD2 POLG2 CAMK4 DNAJC11 TMEM11 TWNK PERM1 IMMT SSBP1 TBL1X HDAC3 SMARCD3 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME IDH2 PRKAB2 DMAC2L SIRT4 SIRT5 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 MUS81 BRCA2 RAD51AP1 SLX4 EME1 BRIP1 EME2 FIRRM RBBP8 ATM FIGNL1 GEN1 SLX1B BLM XRCC2 XRCC3 PALB2 SPIDR RAD50 BRCA1 RAD51 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids CYP4A22 CYP4F11 ADH7 CYP4F12 CYP2A7 CYP2D6 CYP2J2 CYP2A13 CYP4A11 CYP4B1 CYP4F22 CYP2F1 CYP4F2 CYP2B6 CYP4F3 CYP4F8 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD33 CD8B IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 B2M IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 HLA-H IGKV1D-39 V2-19 HLA-B IGKV1D-33 HLA-C TRAC IGKV2D-28 CD3E HLA-A IGKV4-1 CD3D IGHV7-81 TRBV12-3 HLA-F TRAV29DV5 HLA-G TRBV7-9 TRBC1 HLA-E V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 TRAV19 IGLV2-11 TRAV8-4 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CDH1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 CD300A IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 ITGAL IGKV5-2 IGKV1-5 IGLC6 ITGA4 ICAM2 IFITM1 ICAM3 ICAM1 ICAM4 ICAM5 CXADR SLAMF6 CD226 CD1D SH2D1A CD1C CD1B cd21 CD1A SLAMF7 KIR2DS1 KIR2DS2 SIGLEC12 SIGLEC11 SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E CD40LG TREML4 TREML2 CD200 CD22 SIGLEC9 NCR1 NCR2 NCR3 VCAM1 CD200R1 ITGB2 HCST LILRA6 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA LAIR1 MICB NPDC1 GLYCAM1 FCGR2B CD3G KIR3DL1 LILRB1 FCGR3A KIR3DL2 LILRB2 LILRB3 LILRB4 LILRB5 SIGLEC1 C3 SIGLEC8 FCGR1A SIGLEC7 SIGLEC6 SIGLEC5 PVR CD96 OSCAR JAML CD8A KLRF1 CD81 CD300E CD300C CLEC4G CD19 KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG COLEC12 CD99 CD160 CRTAM SELL ULBP1 ULBP3 TREM1 ITGB7 PIANP KLRG1 CLEC2B CLEC2D NECTIN2 TREM2 KLRK1 TYROBP KLRD1 ITGB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential KCNK6 KCNK7 KCNK1 KCNJ2 KCNK5 KCNK10 KCNK12 KCNJ4 KCNK13 KCNJ14 KCNK15 KCNK16 KCNK17 KCNK18 KCNK2 KCNK4 KCNK9 KCNJ12 KCNK3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency PC PCCA HLCS MCCC1 PCCB ACACA MCCC2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function RBP4 TTR STRA6 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO2 FMO3 FMO1 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly IPO5 HSP90AA1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 CHEK1 RAD9B RAD9A RPA1 HUS1 RPA2 EXO1 DNA2 RPA3 RHNO1 TOPBP1 RAD1 RFC5 RFC3 RFC4 RFC2 MRE11 ATRIP NBN BARD1 BRCA2 BRIP1 RAD17 RBBP8 ATM ATR BLM XRCC2 RAD50 BRCA1 RAD51 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP4A22 FDX2 POMC CYP26A1 CYP26B1 CYP2C19 CYP2C18 CYP4F11 NR1H4 CYP4F12 POR CYP2U1 CYP2R1 CYP4A11 CYP26C1 CYP3A43 RXRA CYP11A1 CYP2F1 CYP4F2 TBXAS1 CYP4F3 CYP4F8 CYP2S1 ARNT2 CYP1A1 CYP7B1 CYP2C9 CYP2C8 CYP11B2 CYP2D6 CYP11B1 CYP1A2 CYP2E1 CYP3A4 CYP7A1 CYP8B1 CYP19A1 NCOA1 NCOA2 CYP21A2 ADH7 CYP27A1 CYP2W1 CYP24A1 CYP4B1 CYP4V2 CYP3A5 CYP3A7 CYP2B6 CYP27B1 AHR PTGIS ARNT FDXR CYP51A1 CYP39A1 CYP2A7 CYP2A6 CYP1B1 CYP2A13 CYP2J2 AHRR CYP4F22 CYP46A1 FDX1 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea CAPZB KCNMB1 KCNMA1 VAMP2 MYH9 CLIC5 EPB41L1 RIPOR2 CIB2 PJVK ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 SYP MYO7A TMC2 MYO3B DNAJC5 MYO3A KCNQ4 FSCN2 SNAP25 EZR TWF2 CAPZA1 PCDH15 CABP2 CAPZA2 USH1C CABP1 LRRC52 ESPNL EPB41L3 CDH23 XIRP2 OTOF MYO1C EPS8L2 GRXCR1 STX1A GRXCR2 WHRN RDX LHFPL5 TMIE USH1G STRC MYO15A ATP2B1 MSN TWF1 CASK SPTBN1 CACNB2 CACNA1D RAB3A SPTAN1 CACNA2D2 SYN1 SLC17A8 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling BRAF SHOC2 PPP1CC MRAS YWHAB RAF1 PPP1CB ARAF BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) PTGR1 HPGD ALOX12 ALOX5AP LTC4S ALOX5 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism PDK1 PDHX DLAT PDK4 DLD PDP1 MKLN1 PDP2 LDHC LDHB VDAC1 LDHA PC LDHAL6A LDHAL6B GSTZ1 MPC1 PDHB MPC2 UBA52 ME1 ME3 MAEA GID4 ME2 GID8 RANBP9 UBB FAHD1 GPT UBC MPC1L GLO1 NEK1 RPS27A PDHA2 PDHA1 PDPR WDR26 RMND5B RMND5A PDK3 SIRT4 ARMC8 PDK2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a PMM2 CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism CRYL1 EXT2 NHLRC1 HK2 HS2ST1 HK1 ABO HK3 CHST11 CHST12 CHST15 CHST13 CHST14 ALDH1A1 RBKS KHK UGP2 CHSY1 CHSY3 GAA LUM UXS1 XYLB PPP2R1A PRKACA RHD HS3ST3A1 AGL UBA52 FMOD SHPK CHPF NAGLU CHP1 GYG2 UBB GYG1 UBC RHCE CEMIP RPS27A B3GALT2 B3GALT1 SDC4 SDC2 SDC3 PGAM1 PGAM2 GALK1 ST3GAL4 ST3GAL1 ST3GAL2 SLC37A1 ST3GAL3 SDC1 EXTL2 SLC37A4 FBP1 PC HAS1 FBP2 GALT HAS3 SORD HAS2 EXTL3 HSPG2 BCAN PRPS1L1 RPE NUP214 HS3ST5 HS3ST6 HS3ST4 HS3ST1 PFKL HS3ST2 GALNS PFKM GALM PFKP EPM2A HPSE2 XYLT2 AKR1E2 XYLT1 PFKFB2 GCKR GCK PFKFB1 PFKFB4 PFKFB3 GPC1 SLC9A1 CTSL GPC3 DSEL GPC2 PRKACG GPC5 PRKACB GNS GPC4 GPC6 B3GALT4 B3GALT6 B3GALT5 AGRN UST DCN DSE CD44 GPI PYGB PYGM ACAN PYGL NDST2 NDST1 TPI1 NDST4 B4GAT1 NDST3 ST6GALNAC6 STAB2 TKT GYS2 GYS1 PHKA1 PHKA2 PAPSS2 PAPSS1 TKFC SLC17A5 MANBA GLYCTK B3GNT7 B3GNT4 NUP107 FAM20B B3GNT3 B3GNT2 NUP188 ALDOC ALDOB ALDOA SPAM1 SLC26A11 NUP210 CSGALNACT1 CSGALNACT2 NUP93 KERA PGD NUP205 POM121 SLC26A2 SLC26A1 AAAS LYVE1 HMMR NUP160 POM121C NUP85 TPR NUP88 NUP155 PPP1R3C PHKB NUP153 CHST6 CHST7 ADPGK PGM2L1 CALM1 NUP62 MAN2B2 MAN2B1 NDC1 B4GALT2 SEC13 B4GALT3 CHPF2 CHST1 SLC2A1 NUP133 CHST5 SGSH BPGM CHST2 CHST3 NUP50 RPEL1 AKR1B1 NUP54 MAN2C1 HYAL2 GAPDHS ABCC5 DCXR NUP42 AKR1A1 HKDC1 PXYLP1 NUP43 LALBA B4GALT6 SLC35B3 B4GALT7 SLC35B2 RAE1 B4GALT4 RANBP2 B4GALT5 HS6ST1 HS6ST2 PRELP HS6ST3 B3GAT3 NUP35 B3GAT2 B3GAT1 GNPDA1 GNPDA2 NUP37 IDUA G6PD HEXB NCAN HEXA BGN PGK1 GLB1L3 PGK2 FUT2 GLB1L2 FUT1 VCAN GLB1L FUT4 HYAL1 FUT3 GLB1 SLC35D2 HYAL3 FUT6 HYAL4 FUT5 IDS FUT7 G6PC1 CSPG5 GUSB ARSB FUT9 G6PC2 G6PC3 DERA OGN HPSE GBE1 GALE B4GALT1 PGM2 PGLS PGM1 HS3ST3B1 ST3GAL6 PPP2R5D GAPDH PPP2CA PPP2CB PPP2R1B PRPS2 PRPS1 PHKG1 PHKG2 RPIA ENO1 ENO2 ENO3 ENO4 OMD TALDO1 PCK1 GLCE B4GALNT2 PCK2 EXT1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes RFC5 RFC3 UBB RFC4 RFC2 UBC RFC1 APEX2 RPS27A PCNA POLI UBA52 POLH POLD3 REV1 MAD2L2 POLD2 REV3L TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex TOP2A CDC6 CDC25A E2F5 HDAC1 RBL2 RBL1 MYC RBBP4 PCNA TFDP1 TFDP2 LIN54 LIN37 LIN9 E2F4 LIN52 MAX E2F1 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type MMAA MMUT QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants FLT3 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine CBS CTH GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 CD274 SEM1 PSMA6 PSMA3 PSMC5 COPS5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 GSK3B PSMB5 PSMD7 PSMB2 NEK2 PSMB3 BTRC PSMD2 PSMD3 PSMB1 PSMD1 SKP1 ADRM1 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation H2AC14 H2BC12L APH1A H2AC8 APH1B APP H2AC6 H2AC7 NPPA UBE2L6 FGA ADAM10 HSPG2 PSENEN H4C9 GSN SAA1 H2AC20 IAPP NCSTN H2AX LTF CALB1 NAT8B BACE1 H2BC26 MFGE8 APCS CALCA TSPAN33 CST3 H2BC21 H3-3B TSPAN5 SNCA H2AZ1 H3C8 ODAM SNCAIP SORL1 TSPAN15 TSPAN14 USP9X NAT8 TGFBI INS ITM2B APOA1 H2BC17 APOA4 H2BC12 H2BC13 H2BC14 H2BC15 UBA52 LYZ H2BC11 SIAH2 TTR SIAH1 SEMG1 B2M H3C15 UBB FURIN GGA2 GGA1 GGA3 UBC H2BC9 PRKN H2BC8 H2BC5 H2BC3 RPS27A H2BC1 PRL APOE H2AC19 H2AB1 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling MTTP P4HB APOB CETP APOF LPA FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases SYK FLT3LG HCK FYN LCK FLT3 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex CUL4A POLE4 POLE2 POLE3 CUL4B PCNA RBX1 WDR48 UBA52 RPA1 RPA2 POLD1 RPA3 RFC5 UBB RFC3 RFC4 RFC2 UBC POLE RFC1 UBE2B USP1 RPS27A DDB1 DTL POLD3 RAD18 POLD4 POLD2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PTTG1 NEK2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 PSMD12 CCNB1 BUB1B PSMD11 UBB CDC20 PSMD14 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization COL10A1 COL16A1 COL12A1 COL27A1 COL2A1 COL25A1 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 COL8A2 COL4A6 COL6A3 COL8A1 COL21A1 COL23A1 COL4A5 COL6A6 COL6A5 COL15A1 COL11A1 COL11A2 COL17A1 COL13A1 COL19A1 COL28A1 COL24A1 COL22A1 COL26A1 COL3A1 COL5A1 COL5A3 COL7A1 COL1A1 COL5A2 COL1A2 COL20A1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates NME2 NME3 NME4 NME1 NME6 TXN RRM1 RRM2 GLRX DTYMK CTPS2 TXNRD1 CTPS1 AK1 TYMS AK2 DCTD NUDT13 AK4 CMPK1 AK5 AK6 RRM2B AK7 AK8 AK9 GUK1 DCTPP1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling HGF RANBP9 MET NRAS MUC20 SOS1 HRAS RANBP10 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest EP300 AURKA TP53 ZNF385A CCNB1 PRMT1 RBL2 RBL1 PCNA TFDP1 GADD45A TFDP2 CARM1 CDC25C E2F4 CDK1 BAX SFN IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling IRS1 PIK3R2 PIK3CB NRAS PIK3R1 THEM4 FRS2 PIK3CA FGF1 FGF4 FLT3LG FGF16 FGF9 PDPK1 FGF18 FGF20 SOS1 FGF23 TLR9 FLT3 AKT2 GAB2 FGF6 FGF2 PIK3C3 KLB GAB1 FGF19 FGFR4 TRIB3 PTPN11 IRS2 FGF7 PDE3B FGF22 FGF3 FGF10 PIK3R4 HRAS NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism RNLS BST1 PARP16 PARP14 PARP10 NADK NMNAT3 NMNAT2 NAXE NMNAT1 NAPRT NADK2 NMRK2 NMRK1 NNMT CD38 SLC22A13 PARP6 PARP4 QPRT PARP9 NUDT12 PARP8 NAXD NT5E SLC5A8 SLC25A51 NAMPT NADSYN1 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PARVA ITGB1 PXN ILK CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication RNF19B PIK3R2 PIK3CB PIK3R1 JAK2 HEYL MYC SOX10 MYCN PIK3CA PTPN6 TNRC6C JUP MOV10 CDH5 AGO3 AGO4 AGO1 AGO2 CDC42 FERMT2 CDH11 TNRC6A TNRC6B CLDN5 STRAP TFAP2A PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 POMT2 RELA POMT1 FLNA FARP2 VCL NFKB1 IL6 IQGAP1 TRAF7 PATJ UBA52 ZNF217 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 MOGS PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 VASP PSMB2 PSMB3 PSMD2 PSMD3 RPN1 FYB1 PSMB1 PSMD1 ADRM1 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 KIRREL3 CDH1 KIRREL1 KIRREL2 ACTN3 MAGI2 ACTN4 ZMYM2 CD2AP NPHS1 NCK2 NCK1 JAK1 COL17A1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 TYK2 SRC PCSK6 PARD6B PARD6A TIAM1 CANX LAMC2 CTSS ITGB4 CTSL CTSB MAPK1 ACTN1 MAPK3 CRB3 ITGA6 PLEC CD151 SPTBN1 LAMA3 FURIN PTK2 PCSK7 CSNK2A3 ANK3 TMEM258 LAMB3 KMT5A RB1 SPTAN1 F11R PARD3 H2AC19 H2AC14 VAV2 H2BC12L OST4 ARHGEF4 OSTC STT3A FYN PVR PALS1 ARHGEF6 MDM2 PIP5K1C PRKCSH TCF3 SNAI1 DDOST SNAI2 CTNNA1 TGIF2 DAD1 H4C9 SMARCA4 GANAB H2AC20 NECTIN2 PTPN11 FOXQ1 DNTTIP1 EZH2 ZBTB33 H2AX FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 H3-3B H3C8 TCF12 TYROBP SIRT1 ILK PARVA TESK1 CLDN2 ZC3H12A CLDN6 CLDN4 H2AJ CLDN3 CLDN9 WASL ANG CLDN8 CLDN7 SKAP2 RSU1 CADM3 CADM1 CADM2 ACTN2 PARVB ANGPTL4 CLDN22 CASK CLDN20 CLDN23 H3C15 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 SUZ12 CLDN19 H2BC9 CLDN18 H2BC8 CLDN17 H2BC5 CLDN16 ARHGAP32 CD47 H2BC3 FLNC ADAM33 H2BC1 LIMS2 LIMS1 SIRPG CDH9 IL6ST CDH8 CDH7 CDH6 CDH3 SIRPA IL6R ADAM19 FBLIM1 MPHOSPH8 CDH24 SDK1 SDK2 H2AB1 SIRPB1 CDH10 CDH12 CDH13 CDH17 CDH18 CDH19 PARD6G NECTIN4 H2AC8 NECTIN3 NECTIN1 H2AC6 H2AC7 CTBP2 CTBP1 PTK2B SP1 PRKCI CDH4 SEC11A CDH2 SEC11C DNM2 CSNK2A1 FOXA2 CSNK2A2 CDH15 CSNK2B H2BC26 KLF4 H2BC21 DST KDM1A RAC1 TWIST2 EED TWIST1 ARID1A SPCS3 H2BC17 SPCS2 XIAP SPCS1 H2BC12 H2BC13 H2BC14 H2BC15 ELMO1 ITGB1 DOCK1 HACE1 H2BC11 BIRC2 PXN TLE1 HDAC2 HDAC1 RBBP4 CLDN1 RBBP7 WT1 H2AZ2 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A F2 F8 F9 TPST2 TPST1 VWF F10 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins ALG9 ALG6 MAN1B1 ALG2 ALG3 ALG1 B4GALT1 CTSA RFT1 MGAT2 MOGS GLB1 NEU1 ALG14 ALG13 ALG12 ALG11 DPAGT1 MPDU1 ALG8 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 KLC2 RAC1 CDC42 RHOG KLC1 KIF5B KIF5A RHOA KTN1 KLC4 KLC3 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 SEM1 RMI2 RMI1 TOP3A WRN KAT5 RAD9B RAD9A RPA1 HUS1 RPA2 EXO1 DNA2 RPA3 RHNO1 TOPBP1 RAD1 RFC5 RFC3 RFC4 RFC2 MRE11 ATRIP NBN BARD1 BRCA2 BRIP1 RAD17 RBBP8 ATM ATR BLM RAD50 BRCA1 RAD51 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis PARP1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium CCT2 BBS2 BBS1 RAB3IP BBIP1 TCP1 TTC8 BBS9 SMO BBS7 BBS5 LZTFL1 BBS4 MKKS ARL6 MCHR1 SSTR3 CCT8 BBS10 CCT5 BBS12 CCT4 CCT3 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs WASF2 WASF3 BAIAP2 RAC1 ARPC4 ARPC5 MAPK1 ARPC2 ARPC3 ABI2 MAPK3 WAS NCKAP1L BTK WASL ABI1 NCKIPSD CDC42 BRK1 ABL1 ARPC1B ARPC1A NCK1 ACTR3 ACTR2 PTK2 CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 ACTG1 ACTB WASF1 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events H2AC14 VPS25 NUP37 H2AC8 H2AC6 H2AC7 NUP107 NUP188 HNRNPK H2BC18 NUP210 NUP93 CHMP4C CHMP4B CHMP4A VPS28 H4C9 NUP205 POM121 NUP214 TSG101 AAAS NUP160 POM121C NUP85 TPR CEBPD NUP88 H2AC20 NUP155 NUP153 CHMP2B CHMP2A H2BC26 H2AC17 H2AC12 NUP62 H2BC21 H3C8 CHMP1A NDC1 SEC13 NUP133 H2BC17 VPS37C H2AC25 VPS37D H2BC12 H2AC21 VPS37A H2BC13 VPS37B H2BC14 H2BC15 NUP50 CHMP3 NUP54 CHMP6 H2BC11 CHMP7 VPS4A H3C15 NUP42 MVB12B H2BC9 MVB12A H2BC8 H2BC5 NUP43 H2BC3 H2BC1 RAE1 RANBP2 H2AC19 UBAP1 H2AC1 NUP35 VPS36 SNF8 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins NUP62 TOP2A TOP2B NUP37 PIAS4 PIAS3 CDCA8 NDC1 UBE2I SEC13 TOP1 NUP133 PCNA NUP107 NUP188 RANGAP1 NUP50 SUMO1 NUP54 SUMO3 SUMO2 NUP210 NUP93 NUP205 AURKA POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR BIRC5 NUP88 RAE1 INCENP AURKB RANBP2 NUP155 NUP153 NUP35 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD GCLC GCLM CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis HEY2 WDR5 MESP1 TBX20 SMYD1 TBX1 MEF2C TBX5 MYOCD HAND1 EOMES CTNNB1 TBXT KAT5 KAT2A GATA6 LDB1 FOXO4 GATA4 ISL1 SMAD1 SMAD4 LEF1 NKX2-5 SRF HAND2 HEY1 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 TLR10 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 RBSN MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 PLCG2 MAP2K7 S100A1 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 FGB IRF3 TLR9 FGA PELI1 TRAF3 LRRC14 FGG TRAF6 USP14 IRF7 PELI3 PIK3C3 PELI2 NLRC5 USP18 TIFA HSP90B1 LGMN MAP3K1 S100B SAA1 NOD1 NOD2 TLR1 BPI PTPN11 PPP2R1A S100A9 S100A8 TLR2 BTRC UBE2D1 RELA SKP1 TLR3 CD36 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD UBA52 TLR4 UBE2D2 TBK1 OPTN CUL1 UBB UBC RPS27A UBE2D3 ECSIT SOCS1 PIK3R4 DUSP4 DUSP3 RIPK3 VRK3 APP DUSP6 UNC93B1 DUSP7 NFKB2 NFKBIA GSDME ATF2 CD180 LY86 ITGAM EEA1 CNPY3 TASL SIGIRR IRF5 IRAK3 CHUK IKBKE IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TIRAP DNM1 DNM2 DNM3 TLR8 CTSV PPP2R5D TLR7 MAPK14 JUN CTSS PPP2CA MAPK11 PPP2CB PPP2R1B CTSL MAPK7 CTSK TLR6 FOS TLR5 MAP2K1 CTSB MAPK1 SLC15A4 MAPK3 BTK PTPN4 MAP3K7 BIRC2 BIRC3 APOB LBP UBE2V1 ITGB2 GSDMD TANK MAP2K6 IRAK1 IRAK2 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation TFB2M POLRMT TFAM OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation H2AC14 CDT1 CDC6 H2BC12L KPNA1 H4C9 H2AC20 H2AX ANAPC15 CDC7 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 H3-3B ANAPC7 UBE2C H3C8 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 H2AJ UBA52 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC POLE H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 H2AB1 ADRM1 PSMA5 SEM1 PSMA6 POLE4 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 POLE2 H2AC6 PRIM2 PSMC3 H2AC7 PSMA1 PRIM1 POLE3 PSMA2 POLA1 PSMC4 POLA2 PSMC1 PSMC2 KPNA6 MCM10 DBF4 RPA4 KPNB1 H2BC26 CDC45 MCM7 MCM8 H2BC21 MCM3 MCM4 MCM5 MCM6 MCM2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 RPA1 H2BC11 RPA2 RPA3 CDK2 GMNN H2AC19 ORC5 ORC4 ORC6 ORC1 ORC3 H2AZ2 ORC2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation EP300 HSPA1L PTGES3 HSPA2 AKT1S1 FKBP4 HSPB8 HSP90AB1 CAMK2B HSPA1B HSBP1 CAMK2D HSF1 CRYAB CAMK2A MTOR HSPA8 DNAJB1 CAMK2G CREBBP RPTOR HSPA1A HSP90AA1 MLST8 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins ST3GAL1 ST3GAL2 ST3GAL3 SRPK2 OST4 EDEM2 PARP16 PARP14 SRPK1 OSTC UBE2I PARP10 STT3A STT3B GSK3A ST6GALNAC2 PRKCSH SUMO1 DDOST MAGT1 DAD1 MAN1B1 ST6GALNAC3 PARP6 ST6GALNAC4 PARP4 PRMT1 GANAB ZDHHC11 GALNT1 PARP9 MGAT4C MGAT4A MGAT4B GSK3B PARP8 CANX ZDHHC20 MGAT5 MGAT1 MGAT2 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 ZDHHC9 UBA52 TUSC3 GOLGA7 CSNK1A1 UBB UBC ST6GAL1 TMEM258 MOGS RPS27A RPN2 RPN1 FUT8 MAN2A1 ST3GAL4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 IRS2 LYN EPO STAT5A JAK2 STAT5B EPOR REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome RB1 ZCRB1 DDX5 VHL SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions FGFR2 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose PLIN1 RXRA NR1H3 RXRB NR1H2 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants MAPK3 MAP2K1 MAP2K2 MAPK1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily H2AC14 H2BC12L H2AC8 H2AC6 PUF60 H2AC7 SNRPB2 TCF4 SUPT16H TCF3 CHD2 PHF5A MYOG H4C9 SNRPN MYOD1 CTR9 SKIC8 RTF1 H2AC20 PAF1 H2AX DHX15 H2BC26 H2BC21 H3-3B H3C8 TCF12 DDX46 DDX42 RBM17 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ SMNDC1 U2SURP H2BC11 SNRPD2 SNRPD1 CDC73 SNRPD3 SNRPA1 H3C15 SF3B1 LEO1 SF3B4 H2BC9 SF3B5 H2BC8 SF3B2 H2BC5 SNRPG SF3B3 SF3B6 H2BC3 SNRPE SF3A3 H2BC1 SF3A1 SF3A2 SNRPF SNRPB SSRP1 H2AC19 H2AB1 CHERP H2AZ2 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives ALOXE3 GPX2 ALOX15 GPX1 ALOX12 GPX4 ALOX12B IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport CP ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC11A2 ATP6V0E1 ATP6V1G2 STEAP4 HFE SLC22A17 ATP6V0D1 ACO1 GLRX3 TFR2 ATP6V0D2 ATP6V1A IREB2 FTMT CYBRD1 TF ATP6V0A2 NEDD8 ATP6V0A4 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 SLC46A1 ABCG2 ATP6V0A1 FTH1 SKP1 CAND1 FTL MCOLN1 ATP6V1H TCIRG1 ATP6V0B ATP6V1B2 HMOX1 ATP6V0C ATP6V1B1 HMOX2 UBA52 CUL1 LCN2 SLC40A1 UBB ATP6V0E2 HEPH ATP6V1G3 STEAP3 UBC RPS27A TFRC FBXL5 ATP6AP1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium CYS1 UNC119B ARL3 RP2 NPHP3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors CDKN1A TFAP2A MYC KDM5B TFAP2C TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation NFKB1 APP MAVS NFKB2 NFKBIA TRAF2 AGER S100A12 NFKBIB HMGB1 NKIRAS1 CHUK NKIRAS2 TRIM4 TRAF6 IFIH1 IKBKB TRIM25 MAP3K1 IKBKG S100B SAA1 RIGI RELA RNF135 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 PSMD12 BUB1B PSMD11 UBB CDC20 PSMD14 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle ARHGEF9 CAV1 GFOD1 SRGAP2 IQGAP3 ARHGEF7 RHOQ STOM JUP PAK1 CDC42 SNAP23 SLC4A7 ARHGAP1 PLEKHG3 PAK4 GIT2 MPP7 DLC1 TRIP10 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 ARL13B ARHGAP5 SYDE1 ARHGAP21 RAB7A CDC42BPB CDC42BPA ARHGAP35 SCRIB CPNE8 WWP2 IQGAP1 OPHN1 VANGL1 DEPDC1B PAK2 ARHGAP17 GJA1 CFTR WASL GOPC LAMTOR1 ARHGAP26 STEAP3 ARHGAP33 ARHGAP32 SLC1A5 TFRC DIAPH3 ITSN1 GIT1 PREX1 OBSCN FNBP1 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription ERCC3 ERCC2 SRRT ZNF610 MEF2C SPI1 ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 ZNF705EP DDIT3 ZNF274 ZNF20 ZNF23 ZNF25 ZNF26 GRIN2A ZNF268 ZNF267 ZNF266 ZNF263 CTR9 ABCA6 RTF1 NR2F1 ZNF34 GRIN2B SYMPK NR0B2 NR2F6 COL1A1 PAF1 COL1A2 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 HEY1 ZNF41 HEY2 CTLA4 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 ZNF480 ZNF479 ZNF235 ZNF234 ZNF233 ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT BGLAP CSTF2T ZNF227 ZNF468 ZNF226 ZNF225 ZNF223 ZNF222 ZNF221 CLP1 ZNF461 ZNF460 ATAD2 ZNF77 ZNF79 SKI ZNF70 ZNF71 ZNF74 AGRP PSMD12 ZNF699 PSMD11 ZNF215 NOTCH1 ZNF214 PSMD14 ZNF213 PSMD13 ZNF697 LEF1 RBPJ ZNF696 ZNF212 DLL1 PSMA7 ZNF211 ZNF692 PSMB6 ZNF691 PSMD8 UBE2D3 RORC PSMB7 RORB PSMB4 ZNF208 PSMD6 ZNF205 PSMB5 ZNF689 PSMD7 ZNF688 PSMB2 ZNF446 PSMB3 ZNF445 PSMD2 PITX2 PSMD3 ZNF202 PSMB1 ZNF443 PSMD1 ZNF200 ZNF684 ZNF442 ZNF441 ZNF682 ADRM1 ZNF440 PSMA5 ZNF681 ZFP69B SEM1 PSMA6 FOXP3 PSMA3 NPAS4 SIRT3 PSMC5 ZNF439 PSMA4 ZNF679 PSMC6 ZNF678 ZNF436 PSMC3 ZNF677 PSMA1 ZNF676 PSMA2 ZNF433 PSMC4 ZNF675 PSMC1 ZNF432 PSMC2 PVALB ZNF431 CTNNB1 ZNF430 BLK GRIA2 ZNF671 ZNF670 MAX DLX6 PCF11 FOXO6 FOXO4 FOXO3 FOXO1 ZNF840P ATXN3 YWHAB MOBP ZKSCAN7 ZNF429 ZKSCAN8 XPO1 ZKSCAN3 AKT1 ZNF668 ZNF426 ZNF667 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 YWHAZ ZKSCAN1 SOCS4 ZNF662 ZNF660 FBXO32 ZNF419 ZNF417 ZNF658 ZNF416 ZNF415 STK11 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 MAPK14 PPM1A MAPK11 HAND2 ZNF875 ITGA5 PPM1D ZNF627 ZNF626 GLI3 ZNF625 GLI2 ZNF624 ZNF621 E2F5 ZNF620 E2F6 ZNF860 MGA TBX5 PINK1 ZNF619 RBX1 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 COX4I1 PTPN4 COX4I2 TRIM33 UXT LGALS3 ZNF729 ZNF727 ZNF726 ZNF724 CCN2 ZNF721 ZFP1 ZFP2 ZNF718 ARNT ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 ITCH ZNF324B L3MBTL2 FOXG1 TGFA ZNF709 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 IQSEC3 ITGBL1 MSTN HNF4G YAP1 SATB2 ZFP14 ZNF585B RXRG ZNF585A GAD1 GAD2 VEGFA CCNG2 ZFP28 PRDM7 IHH CCND3 CCND2 NPPA MSX2 CCNK ZNF99 CCNT2 GEM ZNF92 CCNT1 GPRIN1 ZFHX3 AUTS2 GTF2B IL2 IL3 BMP2 TCF3 SUPT16H LDB1 MYBL2 TGIF1 ZNF75CP GTF2F1 RBM14 GTF2F2 TGIF2 ELF1 ELF2 CAT RETN ZNF804B ZNF175 SERPINE1 SUPT4H1 ZSCAN32 JUNB NEDD4L ZNF169 RNF111 GTF2E1 ZNF705G GTF2E2 ZNF705D ZNF160 ZNF705A ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 NKX2-5 NR2C2AP ELOA2 ZNF383 ZNF140 SUPT5H CDC7 NR1D2 CDK9 ZNF37A ZNF702P ZNF138 TAF4B ZNF135 ZNF133 RARG BTG1 ELL TAF7L RSPO3 TEAD1 ELOA ZNF124 NELFB TEAD2 ELOB ZIK1 NELFCD TEAD3 NELFA TEAD4 ELOC TCF12 PAX5 NELFE TAL1 SLBP RARB ZNF599 ZNF114 NCBP1 ZNF597 ZNF596 NCBP2 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 GTF2A1 ZNF583 GTF2A2 CTDP1 ZNF582 RNMT PCGF6 CDKN2B TAF9 PCGF5 PCGF2 WWP1 TAF1L ZNF33B RYBP POLR2A ZNF337 POLR2B ZNF577 ZNF334 POLR2C ZNF333 POLR2D PF4 ZNF573 RXRB ZNF571 POLR2G CSF2 ZNF570 POLR2I TAF9B ITGA2B ZFP30 POLR2J ZNF569 ZNF568 ZNF567 ZNF566 RNGTT TAF15 ZNF565 TAF12 ZFP37 TAF13 ZNF564 TAF10 ZNF563 TAF11 IGFBP1 SSRP1 ZNF562 TAF8 ZNF561 ZNF560 TAF7 NRBP1 ZNF559 TCEA1 ZNF558 TAF6 ZNF557 TAF5 ZNF799 TAF4 ZNF556 TAF3 ZNF555 ZNF554 TAF2 ZNF311 ZNF552 TAF1 ZNF793 G6PD ZNF551 ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL PLXNA4 ZNF300 ZNF782 ZNF540 ZNF658B ESRRB ESRRG ZFP69 CDK6 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 CYCS ZNF770 FKBP5 ZNF529 ZNF528 ZNF764 ZNF521 ZNF761 CR1 ZNF75D ZFP90 ZNF75A ZNF517 CRH ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 AXIN1 ZNF747 ZNF746 ZNF500 ZNF740 PPP2R5C KCNIP3 PPP2CA KLF4 PPP2CB RAD51 ZNF738 ZNF737 ZNF736 PPP2R1B ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 ZNF605 SOX9 ZNF600 ZNF839 INS TWIST2 TWIST1 ZNF726P1 OCLN CITED1 CITED2 CITED4 PARP1 KRABD5 KRABD4 KRABD3 GP1BA RET ZNF2 ZNF3 NPY CAMK4 GATA3 ZNF354C ZNF354B LMO1 LMO2 ATP1B4 LIFR KCTD6 NOP2 SMAD2 SMAD1 SMAD4 SMAD3 HNF4A PIP4K2A SMURF2 SMURF1 SMAD6 ESR2 PIP4K2B SMAD7 NR4A1 PIP4K2C NR4A3 JAG1 THRA CGB8 NR2E1 YBX1 OPRM1 CAMK2B ZNF197 CAMK2D ZNF195 CAMK2A NR2C2 THBS1 HSPD1 MED8 HES1 CAMK2G ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 PRDM1 MYC TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 PIP4P1 TFAP2A TFAP2B WWOX TFAP2C TFAP2D TFAP2E KCTD1 KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 ANAPC10 RELA ANAPC11 FZR1 CDC23 CDC26 CDC27 VENTX TCF7L2 ANAPC7 UBE2C CDKN2A UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 AKT2 AKT3 SNRPD3 SFN ESRRA GPX2 GLS2 PRMT1 TXNRD1 STAT1 COX7A2L TJP1 SNRPG SNRPE SNRPF SNRPB IRAK1 CAV1 YWHAQ YWHAH PDPK1 ARNT2 BMAL1 PTPN11 COX7A2 COX7A1 CALM1 SLC2A3 CCNE2 CCNE1 POMC NLRC4 CASP1 TXNIP SKP2 MET MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 E2F1 TCF7L1 DLX5 JUN SOX2 SNW1 MAMLD1 MYB TSC2 TSC1 CDKN1B ZFPM1 GATA4 GATA2 GATA1 SOCS3 PTPN1 NFE2 CDK4 CDK2 TRPC3 TNFRSF10B FASLG TNFRSF10A FAS SOD2 IFNG PRKCQ PLK2 MDC1 ATF2 TP53RK NOC2L TP53AIP1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 RHNO1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 NUAK1 PCBP4 PRDX1 TP53BP2 ATRIP PRELID3A BANP BARD1 PLK3 PRELID1 CRADD GADD45A TPX2 RAD17 ATM CDK12 CDK13 ATR TP73 CDKN1A BTG2 BDNF SETD9 PRKAG1 CDK5R1 CHM BRCA1 GCK PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 RMI2 BRD1 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D SGK1 PCNA WRN MAPK1 PLAGL1 PERP PMS2 MAPK3 RICTOR BRD7 TIGAR NPM1 RPA1 RPA2 MLH1 HIPK1 POU4F1 EAF1 POU4F2 EAF2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CCNA2 STEAP3 CCNA1 MRE11 SESN3 SESN2 MT-CO1 NBN KMT5A BNIP3L USP7 IGFBP3 SUPT6H USP2 CDC25C MSH2 FANCD2 PRKAB2 AFF4 KAT6A MAPKAPK5 BLM NDRG1 SMYD2 SLC38A9 BCL2L14 MAP2K6 ZNF420 MLLT1 MLLT3 FANCI BRPF1 IWS1 SCO2 BRPF3 TNFRSF10C FANCC MT-CO2 CNOT10 TNFRSF10D MT-CO3 CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 RHEB CNOT2 CNOT3 JMY MDM2 PIN1 MDM4 CNOT8 RAD9B CNOT9 RAD9A PRR5 PPP1R13B DYRK2 TRIAP1 PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA PRKAG2 RBL2 RBL1 MED15 BIRC5 TMEM219 PRKAA1 RNF34 AURKB TP53INP1 RBBP8 E2F4 RFFL E2F7 E2F8 ARID3A MTOR PML RAD50 BAX MED26 HDAC10 EPC1 MED25 PABPN1 PPARD PRMT6 PBRM1 ACTL6B YEATS4 ARID2 HDAC4 THRB UBE2I VDR NR1H2 RORA NR3C1 ESR1 KDM5B NR2C1 NR5A1 NR4A2 AR G6PC1 RXRA SUMO1 SP1 RARA PPARG PGR PPARA HDAC8 TP53 REST PTEN CSNK2A1 CSNK2A2 RRM2B CSNK2B PRKAA2 KIT BRIP1 APOE PCK1 PRKCB MYL9 COX7B COX7C GPAM COX8A SREBF1 COX8C ERBB2 EGFR YWHAE COX5B COX5A PPP2R1A PRKACA COX6C YWHAG SKP1 COX6A1 COX6A2 USP9X UBA52 COX6B2 COX6B1 CPAP CUL1 AURKA CCNB1 UBB UBC HIGD1C RPS27A CDK1 BCL2L11 PMAIP1 BID BBC3 RRM2 CARM1 SRC SRF GLS CTSV NAMPT GAMT CTSL CTSK CGA NR1D1 MMP13 GPI FURIN SPP1 RB1 SMARCB1 CCNH EHMT2 H2AC19 EHMT1 CCNC H2AC14 TRIM28 H2BC12L MED1 SMARCC1 SMARCC2 MED4 MED6 MED7 ZNF28 ZNF273 ZNF708 PPARGC1A PPARGC1B ZNF264 CREBBP ZNF141 H4C9 ZNF382 SETD1B SETD1A SMARCA2 SMARCA4 H2AC20 ZNF30 ZNF136 ZNF257 EZH2 H2AX PHF20 ASH2L MED16 MED17 MED12 MED14 MED13 MED10 H3-3B LBR H3C8 NUDT21 ACTL6A MED27 SIRT1 MED23 NCOR2 KAT2B KAT2A H2AJ MED24 NCOR1 MED20 CPSF7 GPS2 H3C15 TBL1X ZNF224 MBD3 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GATAD2B GATAD2A ZNF33A ZNF354A ZNF454 ZNF331 H2AB1 EP300 ZNF324 MEN1 ZNF320 H2AC8 ZNF680 H2AC6 H2AC7 TBL1XR1 ZNF317 KMT2D KMT2A TXN KMT2C KMT2B WDR33 MED30 MED31 ZNF669 ABL1 PAPOLA ZNF547 ZNF425 HDAC11 RAMAC BMI1 LSM10 CBX5 LSM11 YY1 INTS1 CBX3 INTS3 INTS2 CDK8 RING1 INTS5 CDK7 INTS4 CDK5 MAF INTS7 SKIC8 ZNF418 INTS6 INTS9 HDAC5 INTS8 ZNF778 FIP1L1 INTS11 HDAC9 MNAT1 INTS12 RNF2 INTS13 HDAC6 INTS14 HDAC7 INTS10 GSK3B ICE1 ICE2 SSU72 NABP2 DPY30 CBX8 NABP1 CHD4 CHD3 PHAX PHC2 ZNF143 CBX6 PHC1 ELL2 H2BC26 ELL3 POU2F1 ZC3H8 SIN3B CBX4 RPRD2 CBX2 NFATC2 SIN3A CSTF3 RPAP2 ZNF649 CSTF2 RPRD1B H2BC21 NFYA RPRD1A POU2F2 PHC3 NFYB SNAPC5 SNAPC1 CSTF1 SNAPC2 NFYC SNAPC3 WDR5 SNAPC4 TBP EED ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 ZNF519 H2BC11 CPSF4 CPSF1 CDC73 CPSF3 COXFA4 CPSF2 SMARCD1 HDAC2 SMARCD2 HDAC3 TCF7 SMARCD3 LEO1 HDAC1 RBBP4 RBBP5 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2K POLR2L SMARCE1 H2AZ2 DEK STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation FLT3LG STAT5A STAT5B FLT3 GAB2 PTPN11 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME GSTT1 GGT1 UGT1A1 SULT1A1 SULT1A4 ACY1 SULT1A3 CNDP2 GSTP1 GSTM1 GGT5 SULT1E1 UGT1A9 ABCC3 GGT7 ABCC1 GGT6 ABCC4 ABCC2 UGT1A6 ABCC5 CYP2E1 GGT3P UGT1A10 SULT2A1 ABCG2 UGT2B15 SULT1C4 NAT1 NAT2 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np SHH DHH IHH HHAT TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts NUP62 NUP37 SLBP NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP107 NUP188 EIF4E NUP50 WDR33 NUP54 NUP210 CPSF4 CPSF1 NUP93 CPSF3 CPSF2 NUP205 POM121 NUP214 NXF1 NUP42 AAAS NUP160 ALYREF POM121C NUP85 NUP43 TPR NUP88 FIP1L1 SYMPK RAE1 RANBP2 NUP155 NUP153 NUP35 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B NAGLU TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 TP53 ZNF385A PCBP4 CDKN1A FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) CABIN1 TP53 EP400 ASF1A LMNB1 H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 UBN1 HIRA HMGA1 RB1 HMGA2 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins VPS28 TSG101 UBB MVB12B UBC MVB12A RPS27A VPS37C VPS37D VPS37A VPS37B UBA52 UBAP1 NMT2 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 NTHL1 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes ARNT2 NPAS4 ARNT BMAL1 PLK2 FOS CDK5 INS GEM MAPK1 MDM2 SYT10 MAPK3 RET IQSEC3 RBFOX3 BDNF NAMPT CDK5R1 CREBBP XPO1 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation PPP2R1B CTLA4 PPP2R5E PIK3R2 LYN PIK3CB PIK3R1 MAP3K8 GRAP2 THEM4 RAC1 FYN MAP3K14 PAK2 PIK3CA RICTOR PRR5 PAK1 PDPK1 CDC42 PIK3CD CD28 PIK3CG AKT2 AKT3 PAK3 MLST8 CD86 AKT1 MAPKAP1 CD80 TRIB3 LCK PPP2R1A YES1 PIK3R3 PPP2R5B MTOR PIK3R6 PPP2R5A PIK3R5 PPP2R5D PPP2R5C PPP2CA PPP2CB VAV1 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L SARS1 RPL37A RPL23A RPL36A RPL35A RPL22L1 RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 PSTK RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A RPL37 RPL39 RPLP2 RPS4Y2 EEFSEC RPL21 SECISBP2 RPL18A RPL23 SEPSECS RPL36AL RPL22 RPS4Y1 SEPHS2 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis NOS2 DUSP16 CORO1A HGS UBB ATP6V1H TRIM27 VPS33B RAB7A CTSG UBC PGK1 RPS27A MAPK1 GSK3A SFPQ MAPK3 RNF213 KPNA1 UBA52 RAB5A KPNB1 ENO1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids ACADM HADHB HADHA DECR1 ACADL ECI1 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation COL7A1 BMP1 LAMA3 TLL2 TLL1 LAMC2 LAMB3 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle PIK3R2 RHOJ PIK3R1 CAV1 IQGAP3 ARHGEF7 WAS STOM JUP PAK1 CDC42 SNAP23 SLC4A7 FMNL3 PAK3 ARHGAP1 PAK4 GIT2 NIPSNAP2 MPP7 OCRL CDC42EP1 VAMP3 ARL13B ARHGAP5 SYDE1 ARHGAP21 RAB7A CDC42BPB CDC42BPA ARHGAP35 SCRIB CPNE8 WWP2 OPHN1 TMPO VANGL1 DEPDC1B PAK2 GJA1 WASL LAMTOR1 ARHGAP26 STEAP3 ARHGAP32 SLC1A5 TRIO TFRC WIPF2 DIAPH3 FNBP1L GIT1 DOCK8 PREX1 FNBP1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 PSMA5 SEM1 PSMA6 PSMA3 CDKN2A PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MDM2 MDM4 CHEK2 COP1 UBA52 TP53 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 ATM PSMB5 PHF20 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus RAN NUP37 NUP107 ELAC2 NUP188 TRNT1 NUP210 NUP93 NUP205 POM121 NUP214 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 NUP62 CSTF2 POP5 POP7 TSEN15 NDC1 POP1 SEC13 POP4 RPP30 RTCB NUP133 ZBTB8OS TSEN2 TSEN54 RPP38 RPP21 RPP25 NUP50 TSEN34 DDX1 NUP54 RPP14 C2orf49 RTRAF CLP1 RPP40 CPSF4 XPOT FAM98B CPSF1 NUP42 NUP43 RAE1 RANBP2 NUP35 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions NCAN COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 AGRN COL6A1 COL6A3 CACNA1G CACNA1I COL4A5 COL6A6 NRTN COL6A5 NCAM1 CACNA1S PRNP PSPN GFRA2 GFRA4 ARTN CNTN2 CACNA1D CACNB2 CACNA1C CACNB3 GFRA1 COL9A1 COL9A3 COL9A2 ST8SIA4 CACNB1 CACNB4 GDNF CACNA1H ST8SIA2 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 KLB PLCG1 FGF19 FGFR4 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF6 FGF2 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling ATP6V1H TCIRG1 INS ATP6V1E1 CTSD ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6V1B2 ATP6V0C ATP6V1B1 INSR ATP6V0D1 ATP6V0D2 ATP6V1A PTPN1 ATP6V0E2 ATP6V1G3 ATP6V0A2 ATP6V0A4 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 IDE PTPRF ATP6AP1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 KLB GAB1 NRAS PIK3R1 PLCG1 FGF19 FGFR4 PTPN11 FRS2 PIK3CA FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSMA5 PSMA6 PSMA3 PSME1 PSMA4 PSMA1 PSMA2 PSMA7 PSMB10 PSMB6 PSMB8 PSMB9 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling CBFB FOXP3 RUNX1 AXIN1 ESR1 RSPO3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion HSD17B10 YRDC TRMU OSGEPL1 MTO1 TRIT1 TRMT61B GTPBP3 TRMT10C PRORP REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression EP300 NOTCH1 MAFK NFKB1 NFE2L2 RELA MYC CREBBP DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage APRT MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle RHOT2 RHOT1 TRAK1 TRAK2 MYO19 MFN1 MFN2 RAP1GDS1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport SEC16A GOSR2 SEC23IP CNIH1 CNIH2 GOLGA2 FOLR1 CNIH3 BET1 TFG SEC22B GRIA1 NSF TRAPPC2L F5 TBC1D20 F8 SEC23A AREG CD59 TMED2 SEC24B SEC24A SEC31A SEC24D TRAPPC2 SEC24C TRAPPC3 TRAPPC1 LMAN1 TRAPPC4 TRAPPC5 NAPA STX5 YKT6 CSNK1D TRAPPC9 SEC13 TRAPPC6A CTSZ TRAPPC6B RAB1A SCFD1 RAB1B CTSC PREB TRAPPC10 MCFD2 TGFA SERPINA1 PPP6C PPP6R1 COL7A1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB SAR1B TMED10 LMAN2L STX17 USO1 NAPG LMAN2 SEC31B ANKRD28 SEC16B MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PPIA PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle CCNE1 PTK6 CDKN1B CDK4 CDK2 CCND1 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase NOP10 TERT CDK2 PIF1 CCNA2 CCNA1 SHQ1 DKC1 NHP2 ACD TINF2 RTEL1 TERF1 TERF2 PPP6C POT1 PPP6R3 TERF2IP RUVBL2 GAR1 RUVBL1 WRAP53 ANKRD28 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) MYD88 TLR5 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 CYP17A1 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate TST SQOR TSTD1 SUOX ETHE1 SLC25A10 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PSMA5 FZD1 SEM1 PSMA6 FZD3 PSMA3 DVL2 FZD2 FZD5 PSMC5 PSMA4 FZD4 FZD7 PSMC6 FZD8 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PRICKLE1 PARD6A SCRIB VANGL2 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 SMURF2 UBC SMURF1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 WNT5A ADRM1 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism B3GNT5 CYB5B FA2H CSNK1G2 ARSA SPNS2 SMPD3 SMPD2 SMPD4 ORMDL2 M6PR ABCG2 SMPD1 ORMDL3 ORMDL1 ALDH3B2 GAL3ST1 ALDH3B1 ARSL ARSJ SPHK2 ARSK ASAH1 ARSH ASAH2 ARSI ST8SIA5 ARSF ARSG ARSD CTSA ACER2 GBA1 ACER1 ENPP7 ACER3 SAMD8 UGT8 SPTLC1 SPTLC2 SPTLC3 ABCC1 B3GALNT1 VAPA VAPB B4GALT6 B4GALT5 GBA3 GBA2 DEGS1 DEGS2 PSAP SGPP2 SGPP1 ST3GAL2 SPHK1 SUMF2 ST3GAL3 SUMF1 HEXB HEXA GLB1L3 FUT2 GLB1L2 KDSR FUT1 GLB1L GM2A GLB1 UGCG ARSB GALC A4GALT CERS3 OSBP CERS4 GLA CERS5 CERS6 SPTSSB SPTSSA PRKD3 PRKD2 CERS1 PRKD1 CERS2 PLPP3 B3GALT4 PLPP2 PLPP1 ST3GAL5 CERK SGPL1 STS MFSD2B NEU2 NEU3 ST6GALNAC5 NEU1 ST6GALNAC6 B4GALNT1 SGMS1 PPM1L SGMS2 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance RPS6KA3 RPS6KA5 EIF4A3 RPS6KA2 CASC3 RPS6KA1 MAGOH ALCAM SCN11A SCN10A AGAP2 L1CAM LYPLA2 DSCAML1 SHC3 RAP1GAP DAB1 PTPRA CNTNAP1 SPTB ITGA9 NTN4 ABLIM1 CDC42 ABLIM2 ABLIM3 NFASC EPHB6 RPS6KA4 CUL2 EPHB2 EPHB1 RBM8A EPHB4 SCN1B SCN1A EPHB3 EPHA5 EPHA7 EPHA6 EPHA8 ANK2 SHTN1 UPF3B KCNQ2 MAGOHB KCNQ3 EPHA1 EPHA3 RNPS1 GRIN2B SPTBN4 SPTBN5 EPHA10 MYL12A SCN3B SCN3A SCN2A CD24 SCN2B TRPC7 NRP2 TRPC5 VLDLR CAP1 TRPC6 RGMB TRPC3 GFRA3 RGMA TRPC4 RELN TRPC1 CAP2 SCN9A NRCAM DSCAM DOK4 DOK5 DOK6 SCN8A EFNA5 PITPNA EFNA4 SPTA1 EFNB2 EFNB1 EFNB3 CFL1 EFNA1 EFNA3 EFNA2 HJV SCN5A PAK2 GAP43 DCX SCN4A SCN4B SHANK3 MSN LAMA1 SCN7A PDLIM7 PSMD12 PSMD11 PSMD14 PSMD13 RPLP1 PSMA7 RPLP0 PSMB6 PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 RPLP2 PSMB5 PSMD7 PSMB2 VASP PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ENAH EPHA4 ADRM1 PSMA5 SEM1 PSMA6 LYN PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 MYH9 PSMC2 SH3KBP1 DLG1 EZR PRKCA PABPC1 RPL22L1 MYO10 RDX TIAM1 HSPA8 CDK5R1 EIF4G1 ITGA5 PRKACG CNTN1 PRKACB MAP2K1 MAP2K2 RBX1 MAPK1 MAPK3 NUMB PIK3CD SOS1 SPTBN2 PRKAR2A DAG1 YES1 HRAS RASA1 NRAS PIP5K1C UNC5A UNC5B DCC UNC5C UNC5D LDB1 NTN1 RPL23A PIK3R3 ST8SIA4 NELL2 SLIT3 ELOB ELOC NCBP1 RPL27A NCBP2 WASL RPS6KA6 CXCR4 CNTN6 CHL1 ITGA2 ITGA10 ANK1 ITGA2B DLG3 NCAN PLXNA4 GRIN1 CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 CSNK2A1 DNM3 AP2S1 SH3GL2 CSNK2A2 ROCK1 CSNK2B RPL26L1 RPL4 ROBO2 RPL5 ITGB1 RPL30 RET RPL3 RPL32 EPHA2 RPL31 RPL34 RPL8 RPL6 RPL7 RPL36 SLIT2 RPL35 RPL38 TRIO RPL37 RPL39 ITSN1 GFRA1 RPL21 RPL23 GDNF RPL22 CACNA1H PSEN2 RPL24 PIK3R2 MYL6 RPL27 PIK3CB APH1A PIK3R1 APH1B RPL26 MYL9 RPL29 NGEF RPL28 FRS2 PIK3CA ITGB3 RPL41 RPL3L ITGAV ARPC1B ARPC1A PSENEN ERBB2 PLCG1 EGFR SEMA5A PRKACA RPL10 HSP90AA1 RPL12 RPL11 RPL14 FARP2 RPL13 RPL15 RPL18 RPL17 RPL19 CXCL12 RPS15 RPS14 UBA52 RPS17 RPS16 RPS19 RPS18 RPS11 SHC1 RPS10 DOK2 PLXND1 RPS13 UBB RPS12 CACNB2 CACNA1D CACNB3 CACNA1C UBC RPS27A CLASP1 RPS4Y2 SDC2 RPS4Y1 FLRT3 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 RPS26 ARPC5 RPS25 RPS28 RPS27 RPS29 ARPC2 RPL7A ARPC3 RPS20 RPS21 RPS24 PLXNB1 RPS23 NRP1 GRB10 MSI1 HOXA2 ISL1 RPL37A ADAM10 COL4A5 NCK2 GSPT2 GSPT1 UPF3A NCK1 LHX3 LHX2 ACTR3 LHX4 RPL36A LHX9 ACTR2 USP33 ROBO1 UPF2 ETF1 RPL35A PSEN1 ZSWIM8 SLIT1 EVL NCSTN SOS2 SRC ROCK2 COL9A1 COL9A3 COL9A2 LAMC1 RPS27L RPS15A GPC1 RPS3 RPS2 COL4A2 COL4A1 MMP2 COL4A4 COL6A2 FAU COL4A3 MMP9 AGRN PFN1 COL6A1 PFN2 GRB7 COL6A3 RPS9 COL6A6 RPS7 KALRN COL6A5 RPS8 MYL12B RPS5 SPTBN1 RPS6 RPSA PTK2 ANK3 RPL39L LAMB1 SPTAN1 GIT1 VAV3 RHOC ACTB VAV2 RHOB FYN ARHGEF7 RPL10L RPL10A HSP90AB1 RPS4X PAK1 RPS3A AKAP5 GAB2 PAK6 PAK3 PAK5 PAK4 RANBP9 MYO9B PTPN11 SDCBP ARHGAP39 ACTG1 TREM2 TYROBP RPL13A ARHGEF28 MYH14 MYH11 MYH10 IRS2 DLG4 RND1 RPL18A ARHGEF11 RPL36AL ARHGEF12 CLTB PPP3CB CLTCL1 CLASP2 DPYSL4 LIMK2 DPYSL5 LIMK1 DPYSL2 DPYSL3 PLXNC1 ABL1 SEMA6A SEMA6D ITGA1 SEMA7A SEMA3A GAB1 CRMP1 MET SEMA3E RRAS PLXNA2 PLXNA3 SEMA4A CD72 CDK5 SEMA4D PTPRC FES PLXNB3 NEO1 GSK3B CACNB1 CACNB4 TLN1 MAPK7 ARHGAP35 RAC1 RHOA DOK1 DOCK1 SIAH2 SIAH1 CACNA1G RPL9P9 CACNA1I NRTN NCAM1 CACNA1S PRNP PSPN GFRA2 GFRA4 ARTN CNTN2 KIF4B KIF4A ST8SIA2 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins PCGF2 PHC3 BMI1 DNMT3B UBE2I RING1 DNMT3A RNF2 DNMT1 SUMO1 CBX8 PHC2 PHC1 CBX4 CBX2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization LTBP4 LTBP2 LTBP3 LTBP1 TGFB2 TGFB3 ITGB3 BMP10 ITGA9 NTN4 ITGB5 ITGB8 FGB ITGAV FGA ITGB6 TGFB1 FGG LUM PECAM1 COL1A1 COL1A2 ADAMTS2 ADAMTS3 LAMA1 FMOD ADAMTS14 SPARC DMP1 MUSK DTNA DTNB GDF5 SSPN DDR1 PTPRS ELN CEACAM6 MATN1 CEACAM8 MATN4 MATN3 DDR2 TNXB DRP2 DMD JAM2 JAM3 DSPP TNC COMP EFEMP2 EFEMP1 IBSP SDC4 TNN TNR UTRN SDC2 FBN2 SDC3 FBN3 VTN FBLN1 FBLN2 NID2 FBLN5 SNTG2 BMP7 ITGA11 FBN1 LAMC3 ITGAE HAPLN1 SGCE SGCD SGCA PRSS1 SGCB COL16A1 ITGAX COL12A1 SGCG CAPN15 SNTA1 CAPN8 ITGA3 CAPN9 ASPN CAPN6 ITGAD CAPNS1 ITGA7 CAPNS2 SDC1 LAMA2 CDH1 LAMA4 CAPN7 NRXN1 BSG LRP4 CAPN5 LAMB2 CAPN2 SGCZ CAPN3 MFAP5 CAPN1 MFAP4 PRSS2 MFAP3 CAST MFAP2 PHYKPL SNTB1 CTRB2 SNTB2 CTRB1 COL23A1 ADAM10 COL4A5 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 PRKCA COL13A1 HTRA1 PSEN1 KLK2 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 ITGAL COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 CTSV ITGA4 LAMC1 CTSS MMP20 COLGALT2 ADAMTS4 ITGB4 ADAMTS5 ITGA5 MMP25 LOXL3 MMP24 LOXL4 CTSL PLOD3 PLOD2 ADAMTS1 PLOD1 CASP3 CTSK LOXL1 TIMP2 LOXL2 COL10A1 CTSG TIMP1 COLGALT1 COL27A1 ADAMTS8 P3H2 TPSAB1 P3H1 ADAMTS9 CTSD PCOLCE P3H3 CTSB COL2A1 MMP7 LOX MMP1 ACTN1 COL4A2 COL25A1 COL4A1 MMP2 COL4A4 MMP3 ICAM2 MMP8 COL6A2 COL4A3 MMP9 PXDN AGRN DCN ICAM3 ICAM1 MMP10 COL6A1 ICAM4 COL8A2 MMP12 ICAM5 MMP11 COL4A6 MMP14 COL6A3 COL8A1 MMP13 MMP16 COL21A1 MMP15 ITGA6 MMP17 COL6A6 MMP19 COL6A5 CD44 PPIB PLEC LAMA5 CD151 COL15A1 TMPRSS6 PCOLCE2 P4HB COL11A1 LAMA3 COL11A2 PLG SERPINH1 FURIN COL19A1 COL28A1 CRTAP ACAN COL24A1 SPOCK3 SPP1 COL22A1 COL3A1 COL26A1 COL5A1 LAMB3 P4HA1 CMA1 P4HA2 LAMB1 COL5A3 CAPN13 P4HA3 CAPN14 CAPN11 COL7A1 SH3PXD2A COL5A2 CAPN12 DAG1 ADAM12 VCAM1 COL20A1 CAPN10 ITGB2 TLL2 TLL1 KLKB1 F11R BMP2 PDGFB SERPINE1 CEACAM1 ITGB7 FN1 TTR KDR CASK ITGA2 ITGA10 CD47 ITGA2B ADAM19 NCAN BGN VCAN ITGAM ITGA1 PDGFA TRAPPC4 ITGB1 FGF2 NCAM1 BMP4 THBS1 ITGA8 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance H2AC14 H2BC12L PIF1 SHQ1 ACD TINF2 ATRX TERF1 TERF2 POT1 TERF2IP LIG1 H4C9 RFC5 RFC3 RFC4 SMARCA5 RFC2 HJURP RSF1 MIS18BP1 OIP5 H2AC20 CENPW MIS18A H2AX CENPA CENPC FEN1 DSCC1 CHTF18 CHTF8 H3-3B CTC1 STN1 TEN1 CENPT CENPU CENPH CENPI H2AJ CENPK CENPL CENPM CENPN CENPO CENPP CENPQ POLR2A CENPS POLR2B POLR2C POLR2D H2BC9 RFC1 H2BC8 POLR2G H2BC5 POLR2I H2BC3 POLR2J H2BC1 RUVBL2 RUVBL1 WRAP53 POLD3 H2AB1 POLD4 POLD2 H2AC8 H2AC6 PRIM2 H2AC7 PRIM1 POLA1 ITGB3BP POLA2 RTEL1 DAXX POLD1 DNA2 DKC1 NHP2 GAR1 H2BC26 H2BC21 NOP10 H2BC17 PCNA WRN H2BC12 KNL1 H2BC13 H2BC14 H2BC15 NPM1 RPA1 H2BC11 RPA2 RPA3 TERT CDK2 CCNA2 CCNA1 H3-4 RBBP4 PPP6C CENPX PPP6R3 POLR2E POLR2F BLM POLR2H RBBP7 H2AC19 POLR2K POLR2L ANKRD28 H2AZ2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 PLCG2 MAP2K7 S100A1 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 FGB IRF3 FGA PELI1 TRAF3 LRRC14 FGG TRAF6 USP14 IRF7 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 TLR1 BPI PTPN11 PPP2R1A S100A9 S100A8 TLR2 BTRC UBE2D1 RELA SKP1 CD36 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD UBA52 TLR4 UBE2D2 TBK1 OPTN CUL1 UBB UBC RPS27A UBE2D3 ECSIT SOCS1 DUSP4 DUSP3 RIPK3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 CD180 LY86 ITGAM SIGIRR IRAK3 CHUK IKBKE IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TIRAP DNM1 DNM2 DNM3 PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 TLR6 FOS MAP2K1 MAPK1 MAPK3 BTK PTPN4 MAP3K7 BIRC2 BIRC3 LBP UBE2V1 ITGB2 TANK MAP2K6 IRAK1 IRAK2 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA AKT1 DIS3 XRN1 MAPKAPK2 DCP2 ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism AGPAT1 PI4KB AGPAT2 AGPAT3 PIK3R2 SELENOI AGPAT4 PIK3CB AWAT2 PIK3R1 GPAT4 GPAT3 GPAT2 CEPT1 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PIK3CA PLA2G2A DDHD2 MBOAT1 MBOAT2 DDHD1 ETNPPL VAC14 GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 PIP4P1 RUFY1 PNPLA7 MTMR1 PNPLA6 MTMR2 INPPL1 MTMR3 MTMR8 MTMR9 MTMR4 ENPP6 TPTE2 MTMR6 MTMR7 FIG4 ARF3 ARF1 PIK3R4 TNFAIP8 PTPN13 PI4K2B GDE1 SACM1L PI4K2A INPP4A INPP4B PIK3CD PIK3CG INPP5F INPP5D INPP5E INPP5J INPP5K TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PIP5K1A PIP5K1B PIP5K1C PIK3C3 MTMR10 MTMR12 MTM1 MTMR14 OCRL RAB4A SYNJ2 SYNJ1 PIK3R3 RAB5A PIK3R6 PIK3R5 PIK3C2G PIK3C2A PIK3C2B TPTE RAB14 PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 PIKFYVE SBF1 SBF2 BMX LPGAT1 PITPNB CPNE7 PTEN CPNE6 LCLAT1 PLB1 LIPI LIPH GDPD1 CPNE1 GDPD3 CPNE3 MFSD2A GDPD5 MIGA2 DGAT2 PCYT2 CSNK2A1 DGAT1 MIGA1 STARD7 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 CSNK2B GPD1 PLA2G10 PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLA2G6 PLD1 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB CHKA OSBPL5 STARD10 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP OSBPL10 PIP4K2A ACP6 PLA2G4F PLA2G12A PCYT1B PIP4K2B PCYT1A PLA2G4D PIP4K2C PLA2G4E PLA2G4B PLA2G4C PLAAT1 PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PI4KA PLA2G1B REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus H4C9 H2BC21 H3-3B H2BC12L H2BC9 PRM2 SRPK1 H2BC8 PRM1 H2BC5 H2BC3 METTL23 H2BC1 H2BC17 H2BC12 H2BC13 HIRA H2BC14 H2AX H2BC15 NPM2 H2BC11 H1-8 H2BC26 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function RDH12 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN DTX4 MRE11 XRCC6 XRCC5 STING1 PRKDC TBK1 TREX1 IRF3 NLRC3 IFI16 NLRP4 DDX41 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels KCNJ4 KCNJ14 KCNJ12 KCNJ2 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC1 APOBEC2 APOBEC3H APOBEC4 ADAR ADARB1 A1CF APOBEC3A APOBEC3B APOBEC3C TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE TLR3 TICAM1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 ABCA1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis F12 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception CAPZB LRP10 LRP12 SCN1B CAPZA1 CAPZA2 LRAT TRPM5 SCN3A SCN2A TRPM4 SCN2B RBP4 RBP2 RBP1 SCN9A RETSAT SCN4B MSN GPIHBP1 OPN1LW PRKCQ STRA6 SLC24A1 VAMP2 MYH9 EPB41L1 CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 SYP RDH5 MYO7A TMC2 MYO3B DNAJC5 MYO3A KCNQ4 FSCN2 EZR TWF2 PCDH15 PRKCA CABP2 USH1C CABP1 OR11H2 LRRC52 OR11H1 ESPNL OR2M7 EPB41L3 OR11H4 OTOG OR2M5 CDH23 OR2M4 CHRNA10 OR2M3 XIRP2 OR4K17 OTOF OR1K1 MYO1C KCNN2 OR2M2 EPS8L2 OR4Q3 MPP1 OR4Q2 GRXCR1 OR10AC1 GRXCR2 OR2AE1 WHRN OR11H6 RDX OR11H7 LHFPL5 GNAT1 OTOGL OR2L8 TMIE OR2L5 USH1G OR11G2 STRC OR1J4 MYO15A OR2L3 SLC26A5 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 RBP3 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR4N5 OR2J3 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 ADCY3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 APOB OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 LRP1 CACNA2D2 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 LRP2 OR10G6 OR10G8 KCNMB1 OR10G7 KCNMA1 OR10G9 LRP8 GUCA1B GUCA1A GUCA1C OR52W1 OR1S2 OR1S1 OR13D1 RDH11 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OPN1MW OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 LDB1 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 PPEF1 OR13C2 OR13C5 OR13C4 OR5AR1 OR1Q1 OR2S2 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 CNGA1 OR2Y1 STX1A OR8D4 OR8D2 OR56B4 OR8D1 NMT1 OR7A17 OR6C70 NMT2 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 RCVRN OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 METAP1 METAP2 CASK OR7G2 OR8I2 OR7G1 OR9K2 CHRNA9 TAS2R20 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 GNAL OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 AKR1C1 OR5B2 OR5D14 OR8H3 AKR1C3 OR5D13 OR5AL1 OR8H2 OR8H1 AKR1C4 TAS2R10 TAS2R13 EBF1 DHRS3 TAS2R14 TAS2R16 OR52M1 OR10V1 DHRS9 OR4C12 OR2AT4 RDH10 OR4C11 RDH16 OR6C6 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 KCNJ2 OR6C1 OR4C13 OR8G1 OR9I1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 TAS2R30 OR51I2 TAS2R31 OR10S1 TAS2R38 SNAP25 TAS2R39 OR52K2 OR51I1 OR52K1 RPE65 OR9G9 OR4D11 PLB1 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 TAS2R50 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 CNGA2 GUCY2D OR8K1 CNGA4 HSD17B6 GUCY2F OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 CNGB1 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 RHO OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 APOM OR2D2 OR52E4 OR5J2 APOE OR52E2 OR52E1 OR2W5P CAMKMT OR5AC2 RGS9BP OR5AC1 OR52E8 OR52E6 CLPS OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 AWAT2 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 GRK1 OR2AK2 GRK7 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR10K2 OR4F4 OR2B2 OR4F3 OR10K1 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 GSN OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 TAS2R7 RTP2 OR52J3 TAS2R8 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 HSD17B1 OR10AG1 OR6Q1 OR8U3 OR8U1 GRM4 TAS2R1 TAS2R3 TAS2R5 PLCB2 TAS2R4 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 SAG OR2B11 OR2AP1 OR51F2 OR2G6 OR5M9 OR51F1 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 TAS1R2 TAS1R1 TAS1R3 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 CACNB2 CACNA1D OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 ITPR3 SDC4 SDC2 SDC3 SLC17A8 SDC1 SCNN1G SCNN1D SCNN1B SCNN1A HSPG2 LHX2 ANO2 GPC1 GPC3 GPC2 GPC5 GRM1 GPC4 GPC6 AGRN TWF1 SPTBN1 AKR1B10 RAB3A SPTAN1 SYN1 LDLR GNAT3 OPN1SW CALHM1 CALHM3 RDH12 ATP2B1 CALM1 FNTA FNTB APOA2 APOA1 APOA4 RLBP1 CYP4V2 TTR BCO2 BCO1 APOC3 GNG13 APOC2 GNB1 GNB3 GNGT1 PDE6B PDE6A PDE6G LPL PNLIP ABCA4 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence CDKN2A MAPK1 MDM2 MAPK3 CDKN2D MDM4 CDKN2C ID1 TNRC6C MOV10 E2F2 AGO3 ERF UBA52 AGO4 SP1 AGO1 TNRC6A TNRC6B CDKN2B CDK6 TP53 UBB ETS1 CDK4 UBC RPS27A TFDP1 TFDP2 RB1 ETS2 E2F1 E2F3 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 PRKAR2A ROBO2 PRKACG PRKCA PRKACA PRKACB AKAP5 PPP3CB RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib CDC37 ERBIN ERBB2 HSP90AA1 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation EXT2 CHST14 CHSY1 KERA MAN1B1 SLC26A2 LUM SEMA5A POMT2 SPON2 CHST6 SEMA5B SPON1 THSD7B DPAGT1 GNE POMT1 ADAMTSL1 MPI ADAMTS2 C1GALT1C1 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL3 ADAMTSL2 MUC12 DOLK MUC15 THSD7A CTSA ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 CHST3 THSD1 THSD4 ADAMTS10 ADAMTS15 FMOD ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 ALG8 MUC6 ALG9 MUC16 ALG6 GALNT3 ALG2 MUC17 ALG3 MUC19 ALG1 C1GALT1 NOTCH1 SSPOP MUC5B MUC20 MUC21 MOGS B4GALT7 LFNG SDC4 PRELP SDC2 DHDDS SDC3 GALK1 MPDU1 B3GAT3 ST3GAL3 HEXB NCAN HEXA BGN VCAN NUS1 SDC1 GLB1 GALT CSPG5 OGN HSPG2 BCAN GALE B4GALT1 DPM1 DPM2 DPM3 ADAMTS16 ADAMTS18 PGM1 GALM NOTCH2 NOTCH3 NOTCH4 ADAMTS4 ADAMTS5 MUC13 GPC1 ADAMTS1 GPC3 GPC2 GPC5 GFPT1 ADAMTS8 GPC4 MGAT2 ADAMTS9 GPC6 SRD5A3 B3GALT6 ALG14 ALG13 DCN AGRN ALG12 ALG11 OMD ADAMTS13 ACAN RFT1 B4GAT1 DAG1 NEU1 LARGE1 POMGNT1 THBS1 PAPSS2 PMM2 EXT1 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNA1 KPNB1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins ISCU DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot SERPINE1 PLG SERPINE2 SERPINF2 PLAUR SERPINB2 PLAT ANXA2 SERPINB8 SERPINB6 PLAU HRG S100A10 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic CAPZB AGPAT3 DYNC1LI1 DYNC1LI2 PLA2G6 DYNLL1 DCTN1 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 DYNC1I1 CAPZA1 CAPZA2 DYNLL2 CAPZA3 ACTR10 GALNT1 ACTR1A PLA2G4A RAB18 DYNC1H1 RAB3GAP2 RAB6B RAB3GAP1 DCTN6 DCTN5 BICD1 DCTN4 BICD2 RAB6A GALNT2 PAFAH1B3 PAFAH1B2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H3 MYLIP RXRB NR1H2 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs CDH1 MYCN TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A MYC TNRC6B DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS GPC1 EXT2 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 SDC4 AGRN SDC2 SDC3 HSPG2 EXT1 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism NAT8L FOLH1 ASNS SLC25A13 FOLH1B NAALAD2 GOT1 GOT2 ASPG SLC25A12 GADL1 ASPA FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex CUL4A ERCC3 COPS3 COPS6 COPS5 ERCC2 ERCC6 COPS8 AQR CUL4B COPS4 COPS2 PRPF19 CDK7 MNAT1 GPS1 ERCC8 ZNF830 RBX1 ISY1 UBA52 POLR2A UBB POLR2B POLR2C POLR2D UBC POLR2G POLR2I RPS27A USP7 POLR2J GTF2H1 GTF2H2 GTF2H3 XAB2 DDB1 GTF2H4 POLR2E GTF2H5 POLR2F POLR2H XPA CCNH COPS7B COPS7A PPIE POLR2K POLR2L TCEA1 UVSSA NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway DUSP5 PPP2R1B DUSP2 DUSP16 PPP2R5E DUSP1 DUSP10 PAQR3 DUSP8 DUSP4 DUSP9 PTPN7 NRAS DUSP6 DUSP7 PPP5C MAP2K1 MAP2K2 MAPK1 BRAF MAPK3 UBA52 KSR1 YWHAB RAF1 BRAP UBB UBC MARK3 RPS27A ARAF PPP2R1A PEBP1 MAPK12 PPP2R5B PPP2R5A PTPN3 PPP2R5D PPP2R5C PPP2CA HRAS PPP2CB SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells STAT3 LYN INPPL1 PIK3CB IL34 PIK3R1 GAB3 HCK GRAP2 FYN STAT1 THOC5 PLCG2 PIK3CA UBA52 PIK3CD SOS1 GAB2 CBL INPP5D KRAS SHC1 UBB UBC RPS27A PTPN11 SRC CSF1R YES1 CSF1 DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle CPS1 ARG1 NMRAL1 OTC NAGS SLC25A15 ASL ASS1 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 EEF2 DNAJC24 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC MUC16 GALNT3 MUC17 MUC19 MUC12 MUC5B MUC15 MUC20 MUC21 MUCL1 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC13 MUC6 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 BACH1 MAFK NFE2L2 HM13 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism FADS1 ACAA1 ELOVL1 ACOT8 ELOVL5 ELOVL2 HSD17B4 FADS2 ELOVL3 ACSL1 SCP2 ABCD1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System ERLIN2 MAP3K8 S100A1 RAP1GAP CTNNBL1 CTR9 RTF1 TLR1 SEC31A PAF1 S100A9 S100A8 TLR2 CD33 DERL3 DERL1 CTLA4 CD8B DCTN1 ERLEC1 CD4 PSMD12 PSMD11 MRC1 PSMD14 PSMD13 LEF1 ARF1 PSMA7 PSMB6 BRD4 PSMD8 UBE2D3 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 BLK SH3KBP1 YWHAB AKT1 DIS3 PDIA3 YWHAZ CD300A FBXO32 EXOSC7 EXOSC6 EXOSC5 EXOSC4 ITGAL EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 TRIM63 STX4 ITGA4 SPOP PRKACG E2F5 PRKACB THEM4 RBX1 STUB1 PIK3CD PIK3CG KIF3A ITCH WWTR1 YES1 YAP1 HRAS CUL3 NRAS KBTBD7 C3 CCNK CCNT2 CCNT1 TCF3 SUPT16H GTF2F1 GTF2F2 REV1 MAD2L2 REV3L COLEC12 AHCYL1 SUPT4H1 NEDD4L RNF111 ELOA2 SUPT5H CDK9 PIK3R3 PIK3R6 PIK3R5 TAF4B ELL TAF7L TEAD1 ELOA NELFB TEAD2 ELOB NELFCD TEAD3 NELFA TEAD4 ELOC CTSA PAX5 NELFE SEC13 CTDP1 TAF9 WWP1 TAF1L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I TAF9B POLR2J TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 TCEA1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CHUK UBA7 HSPA5 UBE2L6 HERC5 IKBKB IKBKG CLTC CLTA AP2A1 AP2B1 CR1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E ITGB1 KCTD6 SMURF2 SMURF1 CD274 PIK3R2 PIK3CB PIK3R1 HIF1A MYC PLCG2 MYCN PIK3CA PTPN6 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A FGB TNRC6B FGA FGG CCND1 ERAP2 ERAP1 TAP2 TAP1 TAPBP UBE2D1 ANAPC10 RELA ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 UBE2C UBE2E1 NFKB1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EXOSC10 C1D MPHOSPH6 AKT2 AKT3 B2M HLA-H HLA-B HLA-C HLA-A ATG14 HLA-F ITPR1 HLA-G ITPR2 HLA-E ITPR3 RPN2 SAR1B RPN1 PIK3R4 LAG3 PTPRJ CD74 DAPP1 REL PTPN22 SIPA1 RAP1GAP2 NFKBIE MAGT1 RAF1 TRIM4 JAK1 RIPK2 CANX STAT1 TUSC3 MAP3K7 INPP5D TMEM258 UBE2V1 PAG1 FKBP1A VCP IGHG3 IGHG4 IGHG1 IGHG2 CD3G FCGR3A SYK OST4 OSTC FYN STT3A FCGR1A UBE2N TAB2 STT3B B3GNT3 MYD88 CD81 NFKBIB HMGB1 PDPK1 DDOST DAD1 TRAF6 PIK3C3 CR2 BECN1 SEC23A VHL SEC24B SEC24A PTPN11 AP1G1 SEC24D SEC24C AP1S2 AP1S1 AP1S3 AP1B1 VAMP8 CALM1 TREM2 KLRK1 GRAP2 TYROBP KLRD1 LCP2 AP1M2 AP1M1 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 FBXL3 SOCS1 FBXL5 PPP3R1 NFKB2 PPP3CA PPP3CB SKP2 RAP1B MAFK NFE2L2 BTLA TNFRSF14 PTPRC MEF2B SEL1L TCF7L1 LRR1 JUN CCNF KEAP1 CBLB UBE2L3 DCAF1 HERC4 MYB RNF115 HERC3 RNF114 HERC2 HERC1 FBXO7 TRIM21 RAC1 HERC6 FBXO9 KIF5C KIF5B WSB1 FBXO2 KIF5A RNF123 RNF126 HECW2 KIFAP3 CBLL2 TRIM11 KIF20A ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 SIAH2 KLC1 SIAH1 LNPEP EPAS1 MEX3C UBAC1 FBXL8 KLC4 SOCS3 FBXL4 KLC3 DZIP3 KLC2 FBXL7 KIF3B RNF220 RACGAP1 DET1 LRSAM1 KIF3C TRIM9 CDK4 ARIH2 RNF144B GAN PRKN RNF138 RNF130 KIF18A HUWE1 KLHL2 UBE2G1 KIF4B KLHL3 KIF4A UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 KIF11 UBE3C KIF15 UBE3D FBXO27 LTN1 CAPZB RNF19B UBE3A UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A MYLIP KIF23 KIF22 FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 UBE2E2 KIF2A LMO7 FBXO10 FBXO11 IRF1 KLHL41 KIF2C KCTD7 KIF2B TRAIP RNF41 KLHL42 CDC42 UBE2V2 CUL7 CUL5 UBA6 UBA5 CUL2 UBR4 KLHL11 CENPE UBR2 UBR1 KIF26A KLHL13 FBXO44 CAPZA1 FBXO41 FBXO40 CAPZA2 BTBD1 LONRF1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 MKRN1 UBE2U RNF182 UBA3 UBE2O TPP2 TRPC1 BLMH UBA1 UBE2K UBE2M TRIM71 RNF14 KBTBD13 UFL1 RAB7A UBE2Q1 UBE2Q2 TRIM69 UNKL LY96 DTX3L PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 PAK2 ASB13 ASB14 CD14 RNF6 ASB11 ASB12 TLR4 UBE2D2 RNF7 IGHV3-23 RNF4 IGLV ASB17 RCHY1 IGLV2-8 ASB18 IGKV1-16 IGKV1-17 FBXL22 ASB15 IGKV1-12 IGHV3-7 FBXL21P IGHV3-9 PSME2 ASB16 V2-11 FBXL20 IGHV3-30 ZNRF1 ZNRF2 V3-4 V3-3 HECTD1 V2-17 HECTD2 V3-2 HECTD3 IGHV3-33 ASB10 TRIM41 V2-15 IGKV1D-39 RNF25 V2-19 FBXL19 IGKV1D-33 ITK FBXL18 CDC34 TRAC FBXL15 CD3E FBXL16 IGKV2D-28 CD3D FBXL13 IGKV4-1 TRBV12-3 FBXL14 IGHV7-81 PRKCQ FBXL12 TRAV29DV5 TRIM39 CARD11 TRBV7-9 TRBC1 ASB8 V1-11 ASB9 HLA-DQA2 IGKV2D-30 LNX1 HLA-DQA1 V1-16 HLA-DPA1 ASB6 V1-13 ASB7 IGHV4-59 VASP IGHV1-69 TRIM36 TRAV19 HLA-DRB5 ASB4 BCL10 HLA-DRB4 TRIM37 RASGRP2 FYB1 RASGRP1 ASB5 ENAH ASB2 HLA-DPB1 IGLV2-11 ASB3 TRAV8-4 TRIM32 IGLV1-40 HLA-DRA ASB1 IGLV1-47 HLA-DRB3 IGLV6-57 IGLV2-14 LAT HLA-DQB2 IGLV1-44 IGKV3-15 CD101 HLA-DRB1 IGKV3-11 LYN HLA-DQB1 PSME1 V2-8 CD207 V1-20 FCGR1BP IGKV2D-40 IGHV3-11 SEC61A2 IGHV3-13 MRC2 IGKV1D-16 SEC61A1 SEC61G IGLV7-43 IGKV1D-12 SEC61B SEC22B NFKBIA MYH9 PSMB10 IGLV1-51 PSMB8 IGLV2-23 PSMB9 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 PRKAB1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 MAPKAP1 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 MALT1 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKAG1 PRKAG3 FOS RAP1A PCNA PMS2 RICTOR ICAM2 IFI30 BACH2 ICAM1 ICOSLG HOXC4 SLAMF6 MLH1 SOS1 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C PPL CTSO ACTR1B CTSH CTSF CTSE CDC20 CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 ACTR10 CD84 HLA-DOA HLA-DOB SUPT6H ZBTB17 MSH2 VCAM1 ITGB2 PRKAB2 AFF4 TNFSF13B POLI POLH IRF8 DCTN6 DCTN5 DCTN4 MLLT1 MLLT3 IWS1 RILP MCM3AP FCGR2B BCL6 PRR5 EXO1 MLST8 RFC5 LGMN RFC3 RFC4 RFC2 PRKAG2 PRKAA1 RNF34 E2F7 E2F8 MTOR ATF3 PDCD1LG2 MAP3K14 RAPGEF3 RAPGEF4 AICDA BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 PPIA OSBPL1A PTEN CSNK2A1 CSNK2A2 CSNK2B PRKAA2 TRIB3 PRKCB DYNC1LI1 DYNC1LI2 ITGB5 ITGAV PLCG1 DYNLL2 LRRC41 ACTR1A PPP2R1A VAMP3 NEK2 XDH BTRC PRKACA YWHAG SKP1 FBXW11 RASGRP3 DYNLL1 JUND NFATC3 UBA52 STIM1 ORAI2 DYNC1I2 ORAI1 DCTN2 FOSB DCTN3 CUL1 UBB NCF1 NCF2 UBC NCF4 RFC1 RPS27A DYNC1H1 POLD3 POLD2 STAT3 COPS5 CDH1 SNAP23 NCK1 LCK EVL CTSV CTSS CSK RBBP6 CTSL CTSK CTSD CTSB BTK IFITM1 ICAM3 ICAM4 ICAM5 CXADR CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 KIR2DS1 KIR2DS2 SIGLEC12 SIGLEC11 SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 SH3RF1 CD22 SIGLEC9 NCR1 NCR2 NCR3 CD200R1 HCST LILRA6 LILRA1 SMARCB1 LILRA2 LILRA3 LILRA4 H2AC19 LILRA5 NCR3LG1 LAIR2 MICA ACTB LAIR1 MICB VAV1 NPDC1 H2AC14 GLYCAM1 KIR3DL1 H2BC12L LILRB1 KIR3DL2 DERL2 DPF1 RNF5 LILRB2 DPF2 LILRB3 LILRB4 OS9 DPF3 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SMARCC1 SIGLEC6 SMARCC2 RNF185 SIGLEC5 PVR CD96 OSCAR JAML CD8A WAS KLRF1 CD300E PAXIP1 CD300C CLEC4G CD19 PAK1 KLRB1 KIR2DL1 KIR2DL2 CD28 KIR2DL3 KIR2DL4 CD300LB CD300LD CREBBP PAK3 KLRC1 DYNC1I1 CD300LF CD300LG H4C9 CD86 CD99 CD160 CD80 CRTAM SS18L1 SELL ULBP1 ULBP3 SMARCA2 TREM1 ITGB7 PIANP SMARCA4 KLRG1 CLEC2B CLEC2D TRAT1 H2AC20 NECTIN2 PIK3AP1 EZH2 H2AX ASH2L CD36 H3-3B H3C8 SS18 CYBB CYBA NCOA6 ACTL6A MSH6 H2AJ E2F2 PDCD1 H3C15 SUZ12 CD209 H2BC9 H2BC8 CALR H2BC5 IGHM H2BC3 H2BC1 IGHD H2AB1 EP300 H2AC8 ZAP70 H2AC6 H2AC7 ICOS KMT2D KMT2A KMT2C TIRAP MAF SKIC8 IRF4 GSK3B STAT6 DPY30 PAGR1 H2BC26 BCL7A NFATC2 NFATC1 H2BC21 CD79B BCL7C BCL7B CD79A BATF IL4 WDR5 TLR6 KDM6A TBP EED ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 MIB2 H2BC11 RBCK1 CDC73 CEBPA SMARCD1 SMARCD2 TCF7 SMARCD3 BLNK LEO1 RBBP4 RBBP5 POLR2E POLR2F POLR2H RBBP7 POLR2K POLR2L SMARCE1 H2AZ2 ERLIN1 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD ALOX15 LTA4H ALOX5 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases APC MAVS RHOA ESR1 TNFAIP3 OTUB2 OTUD5 OTUD7B TNIP2 OTUD7A VCPIP1 RIPK1 ZRANB1 YOD1 TNIP1 UBA52 RNF128 TNIP3 OTUB1 TRAF3 TRIM4 TRAF6 IFIH1 TP53 TRIM25 UBB IKBKG PTEN RIPK2 NOD1 RIGI NOD2 UBC OTUD3 RPS27A VCP UBE2D1 CDK1 RNF135 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement CFD C3 GZMM CFB MBL2 C2 COLEC11 C1QB C1R C1QC C1S IGHV3-23 IGLV IGLV2-8 IGKV1-16 C4A IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 C4B_2 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 FCN1 V5-4 FCN2 V1-7 FCN3 V5-1 V1-5 CRP V1-3 COLEC10 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1QA MASP1 IGHG3 IGHG4 IGHG1 IGHG2 MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction MYL6 MYL9 SCN11A SCN10A ITGB5 SCN1B SCN1A CACNG7 MYL12A SCN3B SCN3A SCN2A SCN2B PRKACA TRPC1 SCN9A VCL SCN8A SCN5A PAK2 AKAP9 SCN4A SCN4B ANXA2 STIM1 SCN7A MME ORAI2 NPR1 ORAI1 NPR2 NPPC CORIN CACNB2 CACNA1C DMD TPM4 ITPR1 TPM3 ITPR2 ITPR3 KCNK9 KCNK3 ANXA1 SLN ACTN3 ATP1B3 ATP1B2 ATP1B1 MYL11 MYL4 MYL5 MYL7 MYL1 KCNQ1 MYL2 MYL3 KCNJ11 MYL10 DMPK MYL6B ANXA6 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 ABCC9 TNNT2 TNNT3 KCNA5 SORBS1 SORBS3 TCAP KCNH2 TMOD1 TMOD4 TPM2 FXYD4 TPM1 TMOD2 FXYD3 KCNE1 KCNE2 FXYD2 KCNE3 KCNE4 FXYD1 KCNE5 FXYD7 CALD1 FXYD6 CAV3 NEB RYR1 FGF14 RYR2 FGF13 FGF12 RYR3 FGF11 TRIM72 DYSF CLIC2 LMOD1 TBX5 MYH3 MYH8 TRDN MYH6 ASPH TTN CACNG6 TNNI1 TNNI2 TNNI3 DES RANGRF ATP1A4 ATP1A3 HIPK1 ATP1A2 ATP1A1 HIPK2 MYL12B PLN KCNK6 KCNK7 KCNK1 FKBP1B WWTR1 CACNA2D2 GUCY1A2 GUCY1A1 GUCY1B2 GUCY1B1 NOS1 NPPA PAK1 AHCYL1 KCNK5 KCNK10 KCNK12 KCNK13 NKX2-5 KCNJ14 KCNK15 KCNK16 KCNK17 KCNK18 SLC8A3 KCNK2 ATP2B4 KCNK4 ATP2A3 ATP2A2 ATP2B3 ATP2A1 ATP2B2 ATP2B1 SRI CALM1 KCND1 SLC8A1 SLC8A2 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 ALDH2 KAT2B MYH11 ACTN2 PDE5A KCNJ2 KCNJ4 KCNJ12 ITGA1 VIM CACNG8 CACNB1 CACNG4 KCNIP3 TLN1 TMOD3 GATA4 CACNA1G PXN CACNA1I CES1 CAMK2B CAMK2D MYLK CAMK2A CACNA1H CAMK2G SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs ATF1 IRS1 ELK1 RPS6KA3 PIK3R2 RPS6KA5 RPS6KA2 PIK3CB NRAS RPS6KA1 PIK3R1 MEF2A MEF2C MAPKAPK3 FRS2 SHC3 PIK3CA ID1 EGR1 F3 JUNB PLCG1 GRIN2B PTPN11 PPP2R1A BAX SH3GL3 MEF2D NELFB TCF12 RALA KIDINS220 JUND FOSB PTPRS SHC1 IRS2 ADCYAP1 ADCYAP1R1 EP300 STAT3 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 ADORA2A YWHAB REST GAB1 MAPKAPK2 NTRK1 CDK5 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 SRC DNM3 PCSK6 SRF AP2S1 DNAL4 SH3GL2 MAPK12 TIAM1 CHD4 NTRK2 BDNF PPP2R5D CDK5R1 MAPK14 PPP2CA MAPK11 PPP2CB NAB1 NAB2 PPP2R1B LYL1 ARC MAPK7 MAP2K5 VGF TRIB1 PCSK5 TPH1 RRAD ASCL1 EGR2 EGR3 RAC1 EGR4 FOSL1 FOS MAP2K1 ID2 MAP2K2 ID3 RAP1A RHOA SGK1 CDK5R2 RAPGEF1 MAPK1 BRAF CRKL MAPK3 FRS3 SHC2 RALGDS CRK PTPRO RALB SOS1 MAPK13 RIT1 RIT2 NTRK3 FURIN NTF3 DOCK3 HRAS ID4 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery RPS3 RPS2 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS15 RPS23 RPS4X RPS14 FAU RPS17 RPS16 RPS19 RPS3A RPS18 RPS9 RPS7 RPS8 RPS11 RPS5 HNRNPA1 RPS10 RPS13 RPS6 RPS12 RPSA RPS27A EEF1A1 RPS4Y2 RPS4Y1 RPS27L RPS15A CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events CALM1 PRKACG PRKACB MAPK1 ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 KPNA2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A PRKCD PRKAR2B PRKCA CAMKK1 CAMKK2 NBEA PLA2G4A CAMK2B CAMK2D PRKX CAMK2A PRKACA PRKCG PDE1C CAMK2G GRK2 PDE1B PDE1A AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors DRD3 ADRA2B DRD4 DRD5 HTR2B HTR2C HTR2A ADRA2C ADRA2A GPR143 CHRM3 CHRM2 CHRM4 ADRB1 ADRB2 CHRM1 HTR4 HTR6 TAAR3P HTR7 HRH3 HRH2 CHRM5 HRH4 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A HTR1B TAAR5 TAAR2 ADRA1D HTR5A ADRA1B TAAR1 ADRA1A ADRB3 HRH1 DRD1 DRD2 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate NANOG ZEB2 SOX1 ZIC2 OTX2 POU3F1 PAX6 ZNF521 POU5F1 SOX2 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor F8 VWF HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors HCK FYN NUP107 CCNT1 NUP188 RCC1 BANF1 KPNA1 DOCK2 NUP210 CD28 CUL5 NUP93 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 HMGA1 AP1G1 NUP153 AP1S2 BTRC AP1S1 CDK9 AP1S3 SKP1 AP1B1 NUP62 CD8B ELOB ATP6V1H ELOC NDC1 SEC13 AP1M2 NUP133 AP1M1 PAK2 RANGAP1 NUP50 UBA52 NUP54 CD4 B2M PSMD12 PSMD11 UBB NUP42 PSMD14 PSMD13 UBC ARF1 PSMA7 NUP43 HLA-A PSMB6 RPS27A PSMD8 RAE1 PSMB7 RANBP2 PSMB4 RANBP1 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 NUP35 ADRM1 PSMA5 SEM1 PSMA6 RAN PSMA3 PSMC5 NUP37 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PACS1 PPIA XPO1 NUP214 LCK AP2A1 AP2B1 AP2A2 SLC25A5 AP2S1 PSIP1 SLC25A6 KPNB1 RAC1 RBX1 ELMO1 NPM1 SLC25A4 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis RAN POLR2A POLR2B POLR2C POLR2D POLR2G DICER1 POLR2I POLR2J POLR2E POLR2F DGCR8 AGO3 POLR2H AGO4 AGO1 BCDIN3D AGO2 TARBP2 POLR2K PRKRA POLR2L XPO5 DROSHA UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins CALM1 FURIN MAP2K4 MAP2K1 PDCD6IP MAP2K2 MAP2K7 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response CASP3 APAF1 APIP CYCS MAPK1 XIAP UACA MAPK3 AVEN DIABLO CARD8 CASP9 CASP7 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema KLKB1 SERPING1 F12 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 BRCA2 RAD51AP1 BRIP1 RBBP8 ATM BLM XRCC2 PALB2 RAD50 BRCA1 RAD51 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription FOXP2 FOXA2 ZEB2 RB1 STRAP SP1 FOXJ2 KLF9 TFAP2A ARID1A KLF4 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR CXCL6 RPS6KA3 CXCL9 GLP1R CXCL8 RPS6KA2 CXCL1 CXCL13 RPS6KA1 CXCL3 CXCL2 CX3CL1 CXCL5 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CXCR1 CDC42 CCL5 CCR6 CXCR3 CCL4 CXCR2 CCL2 CCL1 CCR2 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 CCL27 LHCGR TRPC7 TSHR FSHR GPHA2 GPHB5 TRPC6 TRPC3 OPN1LW PDYN PRKCQ RASGRP2 RASGRP1 DRD1 DRD2 DRD3 DRD4 DRD5 CX3CR1 AVPR1B ADORA2A AVPR1A ADORA3 ADORA1 AVP AKT1 PRKCD PRKCA PRKCE S1PR1 PDE3B TIAM1 GNAT1 ITGA5 PRKACG PRKACB SST MAPK1 ADCY9 PRKAR1B SMO MAPK3 PRKAR1A ADCY4 ADCY3 ADCY2 SOS1 ADCY1 PIK3CG ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A PTCH1 GNAS HRAS PDE1B PDE1A PDE2A PDE11A PDE10A NRAS IHH C3 OPN1MW AHCYL1 CAMKK1 CAMKK2 C3AR1 PIK3R3 PIK3R6 PIK3R5 CCR5 CXCR4 TAS2R20 PF4 GNAL NBEA GCGR TAS2R10 TAS2R13 PPP1CA TAS2R14 TAS2R16 TAS2R40 TAS2R41 TAS2R43 GABBR2 TAS2R46 GABBR1 TAS2R30 TAS2R31 TAS2R38 TAS2R39 IAPP CRH ROCK1 MCHR1 PPP2R5D PPP2CA PPP2CB TAS2R50 PPP2R1B PLEKHG5 ITGB1 NPY CAMK4 SSTR3 WNT11 RHO WNT4 TRIO WNT9B PLA2G4A ITSN1 OPRM1 CAMK2B RAMP2 CAMK2D CAMK2A PREX1 MGLL CAMK2G PRKCB OPRK1 PIK3R2 MC4R EDNRB PIK3R1 NGEF EDN1 EDN3 ADM MC3R ABR PIK3CA MC1R MC5R NPFFR2 NPFFR1 CALCRL NPFF QRFPR HCRT QRFP HCRTR2 HCRTR1 F2R F2 TAS2R7 EGFR TAS2R8 KNG1 GNAI1 GNAI2 PPP2R1A HCAR2 HCAR3 HCAR1 PRKX PLCB3 PRKACA PLCB4 GRM4 FGD1 TAS2R1 FGD2 GCG TAS2R3 PLCB1 TAS2R5 PLCB2 FGD3 TAS2R4 FGD4 MCF2 CXCL12 AGT CHRM3 AKT2 AKT3 TAS1R2 OXTR TAS1R1 RGSL1 TAS1R3 GRPR EDNRA PROK2 PROK1 PRKAR2B UTS2R PRKCH TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 ITPR1 LPAR4 ITPR2 NTSR1 NTSR2 GPR17 ITPR3 NMB XCR1 NMBR ADCYAP1 LPAR5 OBSCN ADCYAP1R1 LPAR6 NMS NMU GNRH2 GNRH1 PSAP MLN BRS3 GPRC6A GPR132 ADRA2B CCKAR GNRHR FFAR4 FFAR3 GAST FFAR2 GPR39 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PLXNB1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 ADRA2C GPR143 RASGRF2 ADRA2A MT-RNR2 F2RL1 F2RL2 F2RL3 DGKG DGKE DGKD CHRM1 DGKB GPR68 DGKA GPR65 PLEKHG2 PMCH CHRM5 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR SOS2 CASR DGKZ LTB4R2 SRC DGKQ ROCK2 UTS2 DGKK DGKI DGKH ABHD6 NTS MCHR2 HRH1 GRK5 PDE1C TAC3 GRK2 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2C OXT HTR2A TRH GRM1 LTB4R GRM5 BDKRB2 BDKRB1 GNRHR2 XCL2 XCL1 DAGLB RGS18 MMP3 RGS17 CGA RGS19 BTK RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 KPNA2 CCK KISS1 CHRM2 CHRM4 KALRN ADRB1 GIP ADRB2 HTR4 HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 HTR1E NET1 TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A HTR1B AKAP13 TAAR5 TAAR2 HTR5A TAAR1 ADRB3 VAV3 CYSLTR1 RHOC SCT CYSLTR2 RXFP4 VAV1 MRGPRD GNAT3 FFAR1 VAV2 FZD10 RHOB GNAZ RXFP1 ARHGEF9 RXFP2 RXFP3 CRHBP ARHGEF3 GPR176 ARHGEF4 CMKLR1 ADORA2B AGTR2 ARHGEF1 GNAI3 FPR1 FPR3 GHRHR ARHGEF2 GALR3 ARHGEF7 OPN1SW GALR2 GALR1 ARHGEF5 NPBWR1 NPBWR2 ARHGEF6 WNT10B WNT10A GPR15 FZD9 GPR183 PNOC GPR18 PAK1 C5AR2 GPR27 C5AR1 PDPK1 GPR25 GPR20 C5 PTH1R UCN3 UCN2 GPR37 GPR35 GPR32 GPR31 PTH2R RGR PLPPR1 GPR45 PLPPR2 SAA1 PLPPR3 PLPPR4 PLPPR5 CD55 WNT8A WNT8B GPR150 P2RY12 P2RY13 WNT7B P2RY14 GPR55 SCTR ADRA1D ARRB1 WNT7A ADRA1B ADM2 ADRA1A MTNR1A TBXA2R MTNR1B GNA12 GPR83 ARHGEF33 GPR84 ARHGEF35 RLN2 ARHGEF37 RLN3 ARHGEF38 ECE1 ECE2 PRLHR INSL3 CALCA INSL5 PTH2 CALM1 P2RY4 SHH APLN VIPR1 ARHGEF40 VIPR2 RRH OXER1 PTGDR GPR37L1 TAS2R19 KEL TAS2R42 GIPR TAS2R45 ARHGEF26 CRHR1 ARHGEF25 NLN PENK PPY PPP1R1B PDE3A TAS2R60 PTGDR2 RGS9 PPP3CC RGS6 OXGR1 RGS7 GPBAR1 GAL UCN PTGER4 OPRD1 NPB TSHB RAMP3 PTH ECT2 FSHB PTGER2 PTGER3 NPW ARHGEF39 PRLH MAS1 XK GNG10 GHRH CRHR2 MC2R RAMP1 CCL4L2 NPY2R RGS8 GNG12 PDE8B GNG11 PDE8A GNG13 NPY1R PCP2 APLNR GNB2 CALCB GNAQ SUCNR1 GNB1 WNT6 GRK3 CALCR GNB4 GRK6 GNB3 ARHGEF10L WNT2 WNT3 GNB5 OPN3 MCF2L GNAT2 PTCH2 PRKCG OPN5 ARHGEF11 GNGT1 PYY ARHGEF10 WNT5A GPSM1 ARHGEF12 GPSM2 ARHGEF15 GNGT2 TAS2R9 WNT2B ARHGEF17 PPP3R1 ADGRE1 ARHGEF16 WNT1 GRM3 ARHGEF19 FZD1 HEBP1 POMC FZD3 ADGRE2 ARHGEF18 FZD2 GRM2 FZD5 ADGRE5 FZD4 GRM7 FZD7 TIAM2 GRM6 FZD6 APP ADGRE3 FZD8 GPER1 GRM8 PDE4A ARRB2 GPSM3 PPP3CA PTGIR PPP3CB NPY5R PDE4D GLP2R PDE4C GNA14 SSTR1 LHB WNT16 GNA13 GNG3 SSTR2 GNA15 SSTR4 SSTR5 GNG2 CORT GNG5 RGS14 GNG4 NPY4R GNG7 OPRL1 GNA11 PTHLH GNG8 CNR2 CNR1 RGS20 S1PR3 RGS22 S1PR2 S1PR5 RGS11 S1PR4 RGS10 RGS12 PDE7B ACKR1 VIP AVPR2 PDE7A CDK5 CCL3 WNT3A WNT9A MAPK7 RHOA HBEGF DHH CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress EIF2S1 STOML2 EIF2AK1 PHB2 EIF2S3 YME1L1 OMA1 DELE1 EIF2S2 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS CYP19A1 PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation MAPK3 RPS6KA3 RPS6KA2 RPS6KA1 PDPK1 RPS6KA6 MAPK1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling LYN RAC1 FYN ARPC4 ARPC5 CFL1 RHOA ARHGEF28 ARPC2 ARPC3 WASL PAK1 CDC42 LIMK2 LIMK1 KALRN ARPC1B ARPC1A GRIN1 ACTR3 ACTR2 PTK2 GRIN2B ROCK2 ITSN1 SDC2 YES1 TIAM1 ACTG1 ROCK1 HRAS ACTB RASA1 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis H2AC14 AGPAT2 H2BC12L SCD PDK4 THRSP MED1 ACSL1 MED4 MED6 MED7 PAXIP1 PEX11A GPAM PPARGC1A PPARGC1B CREBBP H4C9 LPIN1 PNPLA2 CIDEC H2AC20 H2AX ASH2L MED16 MED17 MED12 MED14 MED13 MED10 CD36 H3-3B NCOA1 NCOA2 H3C8 ELOVL5 NCOA6 NCOA3 MED27 SIRT1 MED23 NCOR2 H2AJ MED24 AJUBA NR5A2 NCOR1 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H3C15 TBL1X H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 FABP4 H2AB1 EP300 PHLDA1 H2AC8 H2AC6 H2AC7 ADIPOQ TBL1XR1 KMT2D KMT2C RXRA LPL MED30 MED31 ABL1 CDK8 CDK5 DGAT2 DPY30 PAGR1 H2BC26 H2BC21 WDR5 KDM6A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CEBPA ACSS3 HDAC3 RBBP5 RB1 H2AC19 CCNC MGLL H2AZ2 LIPE TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation PTGDS NR5A1 ZFPM2 FGF9 DHH SOX9 DMRT1 GATA4 SRY WT1 AMH BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus RB1 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation ATP5PD MICOS13 ATP5PB MICOS10 ATP5MC2 ATP5MC3 APOO APOOL ATP5MC1 ATP5PO MTX2 CHCHD3 CHCHD6 SAMM50 MT-ATP6 ATP5F1A DNAJC11 ATP5F1B TMEM11 IMMT ATP5F1C ATP5MK MTX1 ATP5MJ ATP5MG ATP5F1D ATP5MF ATP5F1E ATP5ME DMAC2L HSPA9 MT-ATP8 ATP5PF IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 IKBKB UBB RIPK3 IKBKG TICAM2 UBC LY96 UBE2N RPS27A UBE2D3 TICAM1 UBE2V1 RIPK1 CD14 TLR4 UBA52 CHUK UBE2D2 UBE2D1 BIRC2 BIRC3 TRAF6 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs SNRPF LSM10 LSM11 SNRPB SNRPG ZNF473 NCBP1 NCBP2 SNRPE SNRPD3 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA HMGA1 BANF1 PSIP1 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry GPC1 GPC3 GPC2 PIK3R1 GPC5 RNASEK GPC4 GPC6 EMC4 LY6E SDC1 PROS1 CD14 AGRN ATG7 UBA7 GAS6 HSPA5 UBA6 MAPRE3 UBA5 HSPG2 TYRO3 HAVCR1 AXL MERTK FURIN MRC1 RPSA CD300A TIMD4 CD209 AP2A1 AP2B1 AP2A2 CLDN1 AP2S1 SDC4 SDC2 CD33 SDC3 UBA3 UBA1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell ADAM17 SHH GPC5 DHH IHH DISP2 SCUBE2 NOTUM APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B ANAPC7 UBE2C CCNB1 UBB UBE2E1 CDC20 UBE2S UBC CDC16 ANAPC4 ANAPC5 ANAPC1 RPS27A ANAPC2 ANAPC15 UBA52 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDK1 CDC23 CDC26 CDC27 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) TUT7 EP300 TUT4 DUX4 TP53 TPRXL TEAD4 DUXA DUXB DPPA4 DPPA2 LEUTX KDM4E TPRX1 YAP1 TPRX2 ZSCAN4 CREBBP TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation EP300 WNT1 CCND3 MED1 ADIPOQ MED4 TBL1XR1 MED6 MED7 WNT10B THRAP3 HELZ2 RXRA CDK19 LPL MED30 MED31 PPARG PPARGC1A PPARA TGS1 CREBBP TGFB1 FAM120B SREBF2 TNF CDK8 CHD9 MED19 MED15 MED18 CEBPD ADIRF SLC2A4 ZNF638 CARM1 MED11 ZNF467 KLF5 CEBPB MED16 MED17 RELA MED12 MED14 MED13 MED26 KLF4 MED10 CD36 MED29 MED28 MED22 NCOA1 NCOA2 MED25 NR2F2 NFKB1 NCOA6 MED21 EGR2 NCOA3 MED27 MED23 NCOR2 MED24 NCOR1 MED20 CEBPA ANGPTL4 PLIN1 LEP TBL1X HDAC3 SMARCD3 CDK4 PCK1 FABP4 EBF1 MED8 CCNC MED9 MED13L ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism GPT TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSENEN PSEN2 APH1A APH1B TIMP2 TGFBR3 TIMP1 PSEN1 MMP14 MMP16 NCSTN DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP9 GP1BA VWF GP1BB GP5 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP9 PNPLA4 PLIN1 FABP1 PNPLA5 FABP2 FABP3 CAV1 PRKACG FABP5 PRKACB FABP6 FABP7 PPP1CB PPP1CC PLIN3 ABHD5 FABP4 PRKACA PPP1CA GPD2 MGLL FABP12 LIPE CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 CYBB CYBA NCF2 ITGB5 NCF4 ITGAV CD36 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response XIAP CASP3 DIABLO APAF1 CASP9 CYCS CASP7 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade CALM1 SLC24A1 GUCA1B SAG GUCA1A GUCA1C FNTA GRK1 FNTB GRK7 GUCY2D PDE6B PDE6A GUCY2F PDE6G RCVRN METAP1 METAP2 PPEF1 CNGB1 PRKCA RHO PRKCQ GNB1 CNGA1 CAMKMT GNAT1 GNGT1 RGS9BP NMT1 NMT2 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C HGSNAT RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SEM1 RMI2 RMI1 TOP3A RAD51D RTEL1 RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 BRCA2 RAD51AP1 BRIP1 RBBP8 ATM BLM XRCC2 XRCC3 PALB2 RAD50 BRCA1 RAD51 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection ERCC3 ERCC2 DOCK2 CUL5 BTRC SKP1 CD8B ATP6V1H PAK2 UBA52 CD4 B2M PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC ARF1 PSMA7 HLA-A PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PACS1 XPO1 NUP214 LCK KPNB1 RBX1 NPM1 FURIN SLC25A4 CCNH HCK FYN CCNK CCNT2 NUP107 CCNT1 NUP188 GTF2B RCC1 BANF1 KPNA1 SUPT16H LIG1 NUP210 LIG4 CD28 GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 POM121 TSG101 SUPT4H1 NEDD4L AAAS GTF2E1 GTF2E2 NUP160 POM121C NUP85 TPR NUP88 XRCC6 XRCC4 NUP155 XRCC5 VTA1 HMGA1 ELOA2 AP1G1 NUP153 AP1S2 SUPT5H AP1S1 CDK9 AP1S3 CHMP2B CHMP2A NMT1 TAF4B AP1B1 NMT2 FEN1 ELL TAF7L NUP62 ELOA NELFB ELOB NELFCD NELFA ELOC CCR5 NELFE NDC1 SEC13 PDCD6IP AP1M2 NCBP1 NUP133 AP1M1 NCBP2 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 TAF1L POLR2A POLR2B NUP42 POLR2C POLR2D MVB12B MVB12A POLR2G NUP43 POLR2I TAF9B POLR2J RAE1 GTF2H1 RANBP2 GTF2H2 RANBP1 GTF2H3 GTF2H4 RNGTT GTF2H5 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 UBAP1 TAF7 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 RAN TAF2 NUP37 TAF1 PPIA CDK7 AP2A1 AP2B1 AP2A2 MNAT1 SLC25A5 AP2S1 PSIP1 SLC25A6 RAC1 TBP ELMO1 POLR2E POLR2F POLR2H POLR2K POLR2L IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A PGLYRP4 MAP2K4 PGLYRP3 MEF2C MAPKAPK3 DEFB105B PGLYRP2 MAPK9 LEAP2 MAPK8 MAP2K7 DEFB1 CLU MAPK10 TNIP2 RAP1GAP HTN1 DEFB109B HTN3 S100A7A BPIFA1 GNLY BPIFA2 EPPIN CCR6 PGLYRP1 ATP7A NFASC PRSS3 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 SLC11A1 DEFB116 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B COL1A2 S100A9 DEFB4B S100A8 TLR2 S100A7 LTF DEFB103B REG3A CAP1 DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 CTLA4 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 PI3 DEFA1B CHGA DEFB104B DEFA6 DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 CD4 BPIFB2 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 PSMD12 CEACAM6 PSMD11 CEACAM8 PSMD14 PSMD13 LEF1 PSMA7 PSMB6 PSMD8 UBE2D3 RORC PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 ITGAX PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 BLK FOXO3 FOXO1 YWHAB TREX1 NLRC3 IFI16 NLRP4 AKT1 NUP214 ADAR DIS3 PRKCD YWHAZ MAPKAPK2 FBXO32 EXOSC7 EXOSC6 EXOSC5 EXOSC4 ITGAL EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 TRIM63 HSPA8 ITGA4 TNFSF13 TNFRSF18 MAPK14 MAPK11 HSPA1A EIF4G1 PRKACG E2F5 PRKACB RBX1 IL2RA STUB1 PTPN4 LGALS3 KIF3A ITCH WWTR1 YES1 YAP1 HRAS CUL3 VEGFA NRAS KBTBD7 CFD C3 GZMM CFB CCNK CCNT2 NUP107 CCNT1 NUP188 IL2 IL3 KPNA1 TCF3 SUPT16H NUP210 GTF2F1 GTF2F2 NUP93 CAT RETN NUP205 POM121 SUPT4H1 JUNB NEDD4L AAAS RNF111 NUP160 POM121C NUP85 TPR NUP88 XRCC6 NUP155 XRCC5 ELOA2 NUP153 SUPT5H CDK9 TAF4B ELL TAF7L TEAD1 NUP62 ELOA TEAD2 NELFB ELOB TEAD3 NELFCD TEAD4 NELFA ELOC CCR5 PAX5 NELFE NDC1 SEC13 NUP133 NUP50 NUP54 CTDP1 TAF9 WWP1 TAF1L POLR2A POLR2B NUP42 POLR2C POLR2D POLR2G CSF2 NUP43 POLR2I TAF9B POLR2J RAE1 RANBP2 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 TAF2 NUP37 TAF1 HEXB GLB1 GUSB ARSB CHUK UBA7 HSPA5 IFI6 EIF2AK3 UBE2L6 ISG15 IFI44L IFIH1 HERC5 IKBKB IFI27 TRIM25 ARIH1 IKBKG ATF6 RIGI FKBP5 CLTC CLTA AP2A1 CR1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E TWIST1 ITGB1 GATA3 FGF2 LIFR KCTD6 PLAC8 SMAD3 SMURF2 SMURF1 SMAD7 YBX1 OPRM1 CAMK2B CAMK2D CAMK2A CAMK2G CD274 IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG HIF1A PTPRZ1 MYC JAK3 MYCN PIK3CA PROS1 PTPN6 TNRC6C MOV10 AGO3 F13A1 AGO4 AGO1 AGO2 CD177 TNRC6A FGB TNRC6B FGA TGFB1 FGG CCND1 F2 KRAS SERPING1 ALOX5 KNG1 F12 EIF2AK2 CSF1R UBE2D1 ANAPC10 RELA ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 UBE2C MUC12 UBE2E1 MUC15 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 MUCL1 MUC3A ANAPC1 MUC5AC ANAPC2 MUC3B CFP RPS15 RPS14 RPS17 RPS16 TBK1 RPS19 MUC1 MUC2 RPS18 AKT2 MUC7 AKT3 MUC4 MUC6 MUC16 RPS11 B2M MUC17 GOLGA7 MUC19 RPS10 RPS13 MUC5B RPS12 MUC20 MUC21 HLA-H HLA-B DNAJC3 HLA-C HLA-A ATG14 HLA-F HLA-G HLA-E RPS4Y2 PLAUR RPN2 SAR1B SERPINB6 PLAU HRG RPN1 PIK3R4 RPS4Y1 IFIT1 IFIT3 IFIT2 PAFAH1B2 SFN ATP8A1 PTPN7 IL34 GAB3 LAG3 PTPRJ CD74 DAPP1 RPS26 ATP6V1E1 RPS25 REL ATP6V1E2 RPS28 PTPN22 ATP6V1G1 RPS27 SIPA1 ATP6V0E1 RPS29 RAP1GAP2 ATP6V1G2 SDC1 NFKBIE RPS20 ATP11B OTUD5 RPS21 RPS24 ATP11A RPS23 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 FCN1 MAGT1 FCN2 ATP6V0D1 IFNA8 FCN3 RAF1 CRP ATP6V0D2 COLEC10 TRIM4 ATP6V1A IKBKE JAK1 TOMM70 RIPK2 ATP6V0A2 ANO6 ATP6V0A4 TYK2 ATP6V1D ATP6V1C1 IL17RC ATP6V1F ATP6V1C2 ATP6V0A1 ATP8B4 IL17RA SIKE1 CANX TLR8 TLR7 RPS27L RNF135 RPS15A RPS3 TCIRG1 RPS2 STAT1 ATP6V0B IFNB1 STAT2 ATP6V1B2 STING1 IL17F ATP6V0C ATP6V1B1 FAU IL17A TUSC3 KPNA2 MAPK13 MAP3K7 RPS9 IFNA14 RPS7 RPS8 IFNA16 RPS5 IFNA17 ATP6V0E2 RPS6 ATP6V1G3 RPSA TMEM258 UBE2V1 MASP1 IFNA10 IFNAR1 FKBP1A VCP TARBP2 IGHG3 TKFC IGHG4 PRKRA IRAK1 IRAK2 IGHG1 IGHG2 NLRP3 CD3G IFNA21 FCGR3A SYK OST4 FGR HCK MAVS OSTC FYN FPR1 STT3A UBE2N FCGR1A FCGR2A TAB3 TAB2 TAB1 STT3B ALPK1 NLRX1 AGER HSP90AB1 S100A12 N4BP1 PRKCSH RPS4X MYD88 NFKBIB MBL2 HMGB1 NKIRAS1 PDPK1 NKIRAS2 RPS3A IKBIP IRAK4 DDOST TLR9 IRF3 DAD1 PELI1 LRRC14 TRAF3 TRAF6 USP14 PELI3 IRF7 PELI2 PIK3C3 NLRC5 USP18 TIFA BECN1 MAP3K1 SEC23A S100B SAA1 NOD1 NOD2 VHL SEC24B SEC24A PTPN11 AP1G1 FTH1 SEC24D AP1S2 SEC24C AP1S1 AP1S3 GPR84 AP1B1 VAMP8 CALM1 FTL RAB5C CHRNB4 AP1M2 TXNDC5 AP1M1 FBXO4 FBXO6 IGF2R FBXW4 FBXW5 FBXW10 FBXW7 OPRD1 FBXW9 FBXW2 CSF2RB CSF2RA CISH CSH1 IRS2 PRL PRLR GHR GH2 FBXL3 SOCS2 GH1 FBXL5 SOCS1 PPP3R1 CCT2 SPHK1 ADGRE5 TCP1 ADGRE3 PPP3CA PPP3CB CCT8 B4GALT1 GMFG SLA2 MCEMP1 RNF216 SEL1L TSLP FUCA2 IL31RA IL18BP OLR1 RAB6A LRR1 JUN STX3 CCNF YPEL5 KEAP1 CRLF2 CBLB SLA UBE2L3 TOM1 DCAF1 ARL8A HERC4 NIT2 MAPK7 RNF115 CIITA HERC3 KIR3DS1 RNF114 TRIM68 HERC2 CDKN1B ACP3 HERC1 SNAP29 FBXO7 TRIM62 TRIM21 RAC1 RNASET2 HERC6 TMBIM1 FBXO9 TRIM56 WSB1 CANT1 FBXO2 TRIM46 RNF123 RHOA TRIM48 RNF126 TRIM45 HECW2 IL2RB CBLL2 TRIM35 TRIM11 TRIM38 ANAPC13 TRIM31 UBE2J2 TRIM34 UBE2J1 ELMO1 RNF213 IL36A ELMO2 RNF217 IL36B DOCK1 ATG7 TRIM29 CRK TRIM26 HACE1 LGALS9 SIAH2 TRIM22 SIAH1 LNPEP C6orf120 SLPI EPAS1 MEX3C TRIM17 UBAC1 CRISPLD2 FBXL8 CBL TRIM14 FBXL4 SOCS3 DZIP3 TRIM10 TMEM63A FBXL7 RNF220 MMTAG2 PTPN1 SYNGR1 DET1 IL36G LRSAM1 NBEAL2 TRIM9 CDK4 IL1F10 ARIH2 IL20 RNF144B IL25 GAN IL26 PRKN IL24 RNF138 FCER1A RNF130 IL11 HUWE1 FCER1G KLHL2 IL15 UBE2G1 IL19 KLHL3 IL16 UBE2G2 RAP2C KLHL9 RAP2B SPSB2 TAX1BP1 VNN1 SPSB1 CAB39 KBTBD6 PGGT1B KLHL5 MAP3K3 NEDD4 IL31 RLIM GCA TRIP12 IL37 KBTBD8 OSM SPSB4 IL18R1 UBE2D4 UBE3C SRP14 UBE3D ENPP4 FBXO27 RAG2 LTN1 RAG1 IRAG2 RNF19B UBE3A ADGRG3 UBE3B IL36RN FBXO21 GGH UBE2Z ADA2 FBXO22 IL7R EIF4A3 MS4A3 NPEPPS TNFAIP6 RNF19A CHI3L1 MYLIP FBXW12 MS4A2 IL1RL2 AREL1 FBXW8 TEC PTX3 THOC5 UBE2E3 FBXO17 CNTF UBE4A FRMPD3 FBXO15 CLEC10A TOLLIP UBE2E2 AHSG LMO7 FBXO10 PLEKHO2 FBXO11 GRN IL10RB KLHL41 CLCF1 KCTD7 CSF3 TRAIP TMEM179B RNF41 RAB3D KLHL42 IL5RA UBE2V2 RAB44 CUL7 LAMP1 CUL5 UBA6 LAMP2 UBA5 IL13RA2 IL13RA1 CUL2 KCMF1 UBR4 ILF2 KLHL11 RAB37 UBR2 UBR1 RAB4B FCAR KLHL13 FBXO44 FGL2 FBXO41 RAB24 FBXO40 CPPED1 IFITM3 BTBD1 IL1RN LONRF1 UBE2F IFITM2 UBE2H CALML5 UBE2B IFIT5 IL15RA KLHL25 IL1R2 ZBTB16 KRT1 GLMN TXK KLHL21 STXBP2 TRPM2 KLHL22 UBE2A VAT1 LIF BTBD6 FBXO30 ORM1 ORM2 KLHL20 FBXO31 CSTB UBE2W SVIP UBOX5 QPCT MKRN1 COTL1 UBE2U IL11RA COPB1 RNF182 UBA3 LPO UBE2O OASL TPP2 OAS1 TRPC1 BLMH OAS3 UBA1 CLEC12A UBE2K IFNL2 UBE2M IFNL1 TRIM71 IFNL3 GBP3 RNF14 KBTBD13 TMEM30A UFL1 GBP5 GBP7 UBE2Q1 SCAMP1 UBE2Q2 TRIM69 RNASE2 TICAM2 UNKL FLG2 LY96 IL20RA DTX3L IL20RB PJA2 IL22RA2 FASLG PJA1 AZU1 TRAF7 HRNR UBE2R2 TRAF2 THOP1 IL22RA1 TICAM1 TRIM50 CASP8 PIGR MGRN1 TMC6 ASB13 SERPINB10 ASB14 SERPINB12 RIPK1 RNF6 RNASEL CD14 ASB11 CTF1 FADD ASB12 TLR4 FLNB RNF7 LRG1 UBE2D2 IGHV3-23 RNF4 HP IGLV ASB17 OLFM4 RCHY1 TXLNA IGLV2-8 ASB18 IGKV1-16 FSCN1 IGKV1-17 FBXL22 PTPRB ASB15 IGKV1-12 FCGR3B IGHV3-7 FBXL21P IL1RAPL1 IGHV3-9 ASB16 PRCP FBXL20 PTPN9 V2-11 IGHV3-30 ZNRF1 PTPN5 ZNRF2 PTPN2 V3-4 HECTD1 VPS35L V3-3 HECTD2 IFI35 V2-17 HECTD3 DHX58 V3-2 IGHV3-33 ASB10 RSAD2 TRIM41 V2-15 DHX36 IGKV1D-39 SURF4 RNF25 FBXL19 V2-19 PRG2 FBXL18 IGKV1D-33 PRG3 CDC34 FBXL15 CYSTM1 FBXL16 IGKV2D-28 QSOX1 FBXL13 CD53 IGKV4-1 FBXL14 IGHV7-81 OSMR PRKCQ FBXL12 CD63 TRIM39 CARD11 PGRMC1 CREG1 ASB8 V1-11 IGKV2D-30 CD58 ASB9 CD68 LNX1 V1-16 IL17C ASB6 V1-13 IGHV4-59 MPO ASB7 TRIM36 IGHV1-69 OSTF1 BCL10 CD93 ASB4 TRIM37 ATAD3B RASGRP2 MID1 RASGRP1 ASB5 DOK3 RASGRP4 ASB2 IGLV2-11 ISG20 ASB3 TRIM32 IGLV1-40 IL7 IGLV1-47 TARM1 ASB1 IGLV6-57 IRF6 IGLV2-14 IRF9 IGLV1-44 MVP IGKV3-15 MX2 IGKV3-11 MX1 LYN PDAP1 V2-8 S100P RIPK3 CNTFR V1-20 IGKV2D-40 ABCA13 IGHV3-11 NHLRC3 IGHV3-13 UNC13D IGKV1D-16 RNF125 A1BG IGLV7-43 IGKV1D-12 CRACR2A PRDX4 NFKBIA IGLV1-51 S100A11 GSDME IGLV2-23 KIR2DS4 IGKV3-20 KIR2DS5 IGHV4-34 PA2G4 IGHV1-2 SERPINA3 IGHV1-46 TRIM8 IGHV4-39 TRIM6 TRIM5 IGKV2-29 TRIM2 IGKV2-28 IGLC3 TRIM3 IGLC1 HAVCR2 IGLC2 SERPINB3 V1-9 NFAM1 V5-4 TMT1A V1-7 AGA V5-1 CARD9 V1-5 ERP44 V1-3 SLCO4C1 GHDC IGKV3D-20 V5-6 CSF3R IGHE EPX IGLV3-19 CLEC4A CLEC4C IGKV2-30 CLEC4D IGHV2-70 CLEC4E IGHV2-5 IGLV3-1 BRI3 IGHV3-48 HVCN1 MALT1 CLEC7A IGLV3-25 NDN IGLV3-27 CLEC6A IGKC PRKCE XAF1 IGKV1-39 PTPN20 PLPP5 IGLV3-21 PTPN23 PLPP4 MYO5A IGKV1-33 KCNAB2 V4-6 MYH2 IL3RA MYO10 IGHV3-53 EIF4E2 V4-2 MYO1C PTPN14 IGLC7 MNDA V4-1 FOLR3 IGKV5-2 PDE12 IGKV1-5 SIGLEC16 IGLC6 SIGLEC15 PTPRN2 SIGLEC14 STK11IP IFNLR1 IL17RE IL17RB CEACAM3 DNASE1L1 IL18RAP DPP7 DNAJC13 CRISP3 HEBP2 CMTM6 ABCE1 MAP2K1 PKP1 RAP1A RAPGEF1 MAPK1 CRKL MAPK3 DSC1 SOS1 PPL P4HB APOB CDC20 PRKAB2 GSDMD CASP9 NOS1 LTA4H SQSTM1 FLT3 LGMN FRK PRKAG2 C3AR1 IL18 IL1A IL1B GSTO1 EIF4A2 EIF4A1 RAPGEF3 EIF4E RAPGEF4 GSTP1 AICDA ACLY SLC27A2 LRRC7 IP6K2 HPSE OSBPL1A SNAP25 PTEN ALAD PGM2 PGM1 PRKAA2 TALDO1 TRIB3 NEU1 BST1 ITGB5 ITGAV GAA APRT ORMDL3 XDH INPPL1 JUND FOSB SHC1 RFC1 DEGS1 POLD3 POLD2 CA1 COPS5 NPC2 GRB10 IFNGR1 IFNGR2 EIF1AX EIF3M GALNS EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H GLA EIF3E CDA EIF3F EIF3C EIF3D EIF3A EIF3B ARMC8 MTAP GNS HMOX1 HMOX2 TCN1 GPI PYGB PYGL RAB3A DERL2 RNF5 OS9 RNF185 NANOG FLT3LG CD19 EGR1 CD28 GAB2 IL33 CD86 CD80 IL1RL1 TRAT1 PIK3AP1 CASP5 CASP4 SDCBP FN1 FNTA FNTB MSH6 C1S E2F2 TTR PDCD1 C4A DHX9 BST2 CD209 RAB14 GRB2 VAPA CALR IGHM IL22 IGHD IL6R PNP PPIE ICOS TXN IL10RA DERA RAB5B MCL1 TIRAP SKIC8 CEBPD IL1R1 CD79B CD79A PTGES2 TLR6 TLR5 C1QA GSTA2 ALOX15 CGAS BLNK HGSNAT OAS2 GBP2 GBP1 IDH1 GBP4 C4BPA C4BPB GBP6 ERLIN1 ERLIN2 TLR10 HK3 PIM1 KPNA7 KPNA4 KPNA5 KPNA3 S100A1 CTNNBL1 PDXK PPM1B NOS3 CTR9 RTF1 PCBP2 SEC31A PAF1 CALM3 CALM2 CD33 DERL3 DERL1 ZBP1 CD8B VCL DDX3X LRRFIP1 IQGAP1 DYNLT1 DCTN1 ERLEC1 CYB5R3 BIN2 MRC1 ARF1 RPLP0 BRD4 ECSIT HSPA1B CLEC5A VTN PGAM1 EIF4G3 EIF4G2 EIF4E3 UNC93B1 VAMP2 PTPN12 PTGS2 C4B_2 SH3KBP1 PDIA3 FABP5 CD300A S1PR1 SERPINB1 STX4 KPNB1 SPOP DTX4 THEM4 PIK3CD PIK3CG NDUFC2 REV1 MAD2L2 REV3L COLEC12 COLEC11 HSP90B1 AHCYL1 ARSA PRKDC STX1A PIK3R3 PIK3R6 PIK3R5 APEH IL9 IL9R CTSA WASL DDX41 ACAA1 TBC1D10C RAB31 TRAPPC1 RAB27A SAMHD1 GDI2 RAB10 RAB18 TNFSF11 PLCG2 DBNL GSN ERAP2 ERAP1 TAP2 TAP1 TAPBP CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K ASAH1 HSPA2 AOC1 AGL EXOSC10 C1D MPHOSPH6 MME GYG1 AIP FPR2 ITPR1 ITPR2 ITPR3 PSAP ANXA1 GM2A PTAFR PTPN13 PFKL IMPDH1 IMPDH2 MAOA MGST1 INPP5D LAT2 AAMP PAG1 GLIPR1 MANBA NME2 AMPD3 B3GNT3 ALDOC CD81 ALDOA CPB2 CFH C5AR2 C5AR1 CFI C2 C5 C6 C7 C9 C8B C8A C8G CR2 CD46 C1QB C1R CPN2 CPN1 CD59 CD55 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC PKM ZEB1 ALDH3B1 HSPA9 TREM2 KLRK1 MAN2B1 GRAP2 KLRC2 TYROBP KLRD1 LCP2 SLC2A3 NAPRT CTSZ ANPEP ATP6AP2 EBI3 IL27 IL6ST CRLF1 IL27RA POMC APP NLRC4 MEFV NFKB2 PANX1 SP100 P2RX7 PYCARD PSTPIP1 AIM2 CASP1 TXNIP CNPY3 NLRP1 SIGIRR SUGT1 IRAK3 SKP2 MLEC RAP1B HGF MAFK NFE2L2 BTLA TNFRSF14 PTPRC EEF1A1 EEF2 MEF2B MAPK12 TCF7L1 PTPN18 SOX2 MYB KIF5C KIF5B KIF5A KIFAP3 KIF20A KLC1 DUS2 KLC4 KLC3 KLC2 KIF3B RACGAP1 KIF3C FAAP24 FAAP20 KIF18A FAAP100 KIF4B CENPX KIF4A FANCM FANCL FANCA FANCB FANCE FANCG FANCF HBB KIF11 KIF15 CAPZB CXCL8 CXCL1 JAK2 KIF23 CXCL2 KIF22 RBSN KIF2A IRF1 CCL11 CCL3L3 IRF2 KIF2C KIF2B DOCK2 CXCR1 CDC42 CCL5 CCL4 SH2B3 CXCR2 CCL2 CCL19 CENPE KIF26A CAPZA1 CCR1 CCL22 CAPZA2 CCL20 PPBP CXCL10 MGAM ILF3 CHIT1 EIF2S3 EIF2S2 EIF2S1 NOS2 ATP6V1H RAB7A RALA PITPNA BOLA2B LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 ITK TRAC CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 VASP TRAV19 HLA-DRB5 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 LAT HLA-DQB2 CD101 HLA-DRB1 HLA-DQB1 DUSP4 PSME1 DUSP3 CD207 VRK3 FCGR1BP DUSP6 SEC61A2 DUSP7 MRC2 SEC61A1 SEC61G SEC61B MYH9 SEC22B PSMB10 ATF2 PSMB8 PSMB9 PRKAB1 DNAJC5 MAPKAP1 CDK13 CDKN1A PRKAG1 PRKAG3 CASP10 FOS PCNA SLC15A4 PMS2 SLC2A5 RICTOR ICAM2 IFI30 BACH2 ICAM1 NPM1 ICOSLG HOXC4 MLH1 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH LAMTOR2 CTSF LAMTOR1 CTSE CTSC LAMTOR3 RELB HLA-DMA MRE11 HLA-DMB APEX2 CD40LG CAPZA3 ACTR10 CD84 HLA-DOA HLA-DOB SUPT6H ZBTB17 MSH2 VCAM1 ITGB2 AFF4 TNFSF13B POLI POLH IRF8 DCTN6 DCTN5 MAP2K6 DCTN4 MLLT1 MLLT3 IWS1 RILP MCM3AP FANCC FCGR2B ATG12 BCL6 ATG5 PIN1 PRR5 EXO1 MLST8 CASP2 HSPA1L RFC5 RFC3 RFC4 HSPA6 APAF1 RFC2 CEACAM1 BIRC5 PRKAA1 RNF34 E2F7 E2F8 MTOR PML TLR3 ATF3 PDCD1LG2 PADI2 MAP3K14 TNFRSF6B EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF12A TNFRSF1B EDAR LTA TNFRSF25 LTB TNFRSF11B TNFRSF11A TNFRSF17 TNFSF18 TNFSF14 TNFSF15 CD70 TNFSF12 TNFRSF9 TNFSF6 TNFSF4 TNFSF9 CD27 TNFSF8 LTBR IST1 BTNL9 BTNL8 BTN2A2 UBE2I BTN3A1 BTN2A1 BTN1A1 RORA BTN3A3 BRWD1 BTN3A2 BTNL2 IL23R IL23A PIAS1 SUMO1 PPIA ARG1 TP53 CPNE1 CPNE3 CSNK2A1 DGAT1 CSNK2A2 ROCK1 CSNK2B MUC13 DSP PLD4 PLA2G6 PLD1 CKAP4 PLD3 PLD2 DSG1 SLC44A2 MT2A LPCAT1 LBP CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 PRKCB AGPAT2 DYNC1LI1 DYNC1LI2 IQGAP2 PRDX6 PLA2G2A NCKAP1L JUP ARHGAP9 ARPC1B ARPC1A PECAM1 PLCG1 DYNLL2 LRRC41 ACTR1A PPP2R1A VAMP3 NEK2 BTRC PRKACA CEP290 YWHAG SKP1 HSP90AA1 FLNA FBXW11 TUBB RASGRP3 DYNLL1 ABI2 NFATC3 UBA52 ABI1 STIM1 OPTN P2RX1 ORAI2 DYNC1I2 ORAI1 DCTN2 DCTN3 CUL1 CENPS UBB NCF1 NCF2 UBC NCF4 STK10 RPS27A DYNC1H1 TUBB4B CDK1 BCL2L11 STAT3 BCL2 FCER2 BCL2L1 ABL2 ARPC4 ARPC5 IL21R ARPC2 ARPC3 CDH1 NF2 CAPN1 PRSS2 SNAP23 BRK1 ADAM10 ADAM17 NCK1 ACTR3 COMMD9 ACTR2 ADAM8 COMMD3 PSEN1 LCK EVL NCSTN SOS2 SRC A2M ELANE SOCS6 SOCS5 CTSV CAND1 CSK CTSS RBBP6 WASF1 MMP25 WASF2 WASF3 CTSL CASP3 CTSK TIMP2 BAIAP2 CTSG TIMP1 CTSD CTSB MMP1 MMP2 MMP3 MMP8 BTK MMP9 IFITM1 ICAM3 ICAM4 ICAM5 CXADR CD226 CD1D CD1C CD1B cd21 CD1A CD44 SLAMF7 LAMA5 DSN1 KIR2DS1 KIR2DS2 SIGLEC12 SIGLEC11 FURIN SIGLEC10 PTK2 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 FAF2 TREML2 CD200 SH3RF1 CD22 SIGLEC9 NCR1 NCR2 C1QBP NCR3 STBD1 CD200R1 HCST RAC2 KLKB1 LILRA6 SPTAN1 LILRA1 SMARCB1 LILRA2 LILRA3 VAV3 LILRA4 H2AC19 RHOG LILRA5 NCR3LG1 LAIR2 RHOF MICA ACTB LAIR1 VAV1 MICB VAV2 NPDC1 H2AC14 GLYCAM1 KIR3DL1 H2BC12L LILRB1 KIR3DL2 DPF1 LILRB2 DPF2 LILRB3 LILRB4 DPF3 LILRB5 SIGLEC1 RHOU SIGLEC8 SIGLEC7 SMARCC1 SIGLEC6 SMARCC2 SIGLEC5 PVR CD96 OSCAR JAML CD8A WAS KLRF1 CD300E PAXIP1 CD300C CLEC4G PAK1 KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD CREBBP PAK3 KLRC1 DYNC1I1 CD300LF CD300LG H4C9 CD99 CD160 IL32 CRTAM SELL SS18L1 ULBP1 ULBP3 SMARCA2 MYO9B TREM1 ITGB7 PIANP SMARCA4 KLRG1 CLEC2B CLEC2D NECTIN2 H2AC20 RAB9B EZH2 H2AX ASH2L ACTG1 CD36 CST3 H3-3B SNCA H2AZ1 H3C8 SS18 CYBB CYBA NCOA6 TSPAN14 ARHGAP45 ACTL6A H2AJ NCKIPSD H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 DIAPH1 CD47 H2BC1 SIRPA H2AB1 SIRPB1 EP300 H2AC8 ZAP70 H2AC6 H2AC7 CD180 MOSPD2 LY86 ITGAM KMT2D EEA1 TASL KMT2A IRF5 KMT2C PTK2B STOM LIMK1 ABL1 VIM TNF IL4R IL13 MAF IRF4 GSK3B CCL3 STAT6 STAT5A DPY30 STAT5B PAGR1 POU2F1 H2BC26 BCL7A NFATC2 NFATC1 H2BC21 BCL7C BCL7B BATF IL4 IL5 WDR5 KDM6A TBP EED ARID1A H2BC17 TNFAIP3 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 MIB2 TNFRSF1A POLR1C H2BC11 CYLD POLR1D RBCK1 BIRC2 BIRC3 CDC73 CEBPA NCAM1 SMARCD1 SMARCD2 TCF7 SMARCD3 LEO1 RBBP4 SERPINA1 RBBP5 POLR2E POLR2F POLR2H RBBP7 TANK CSF1 POLR2K POLR2L SMARCE1 FUCA1 H2AZ2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol HSD3B7 NCOA1 NCOA2 NR1H4 HSD17B4 AKR1D1 CYP27A1 ABCD3 ACOX2 AKR1C1 CYP7A1 BAAT AKR1C3 ACOT8 AKR1C2 RXRA AKR1C4 ABCB11 CYP8B1 AMACR SLC27A2 SLC27A5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CHEK2 CHEK1 PLK3 GSK3B BTRC MAPK14 SKP1 MAPK11 FBXW11 NEK11 CSNK1E RBX1 UBA52 CUL1 PSMD12 CSNK1A1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID IKBKB IKBKG CHUK KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism ACAT1 BDH1 OXCT1 OXCT2 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer EP300 PSEN2 APH1A HDAC4 APH1B HEYL MYC TBL1XR1 HDAC8 ADAM10 CREBBP PSENEN ADAM17 HDAC11 MAML2 PSEN1 CDK8 MAML1 HDAC5 NCSTN HDAC9 HDAC6 DLL4 MAML3 HDAC7 NEURL1 MIB1 SKP1 HDAC10 HEY1 JAG2 HEY2 SNW1 MAMLD1 NEURL1B RBX1 NCOR2 KAT2B KAT2A UBA52 MIB2 NCOR1 CUL1 HDAC2 TBL1X HDAC3 UBB NOTCH1 HDAC1 UBC RBPJ DLL1 RPS27A HES5 JAG1 HES1 CCNC COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes COL16A1 COL12A1 COL23A1 COL4A5 COL17A1 COL13A1 COL1A1 COL1A2 BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 COLGALT2 ADAMTS2 ADAMTS3 PLOD3 PLOD2 PLOD1 COL10A1 COLGALT1 COL27A1 P3H2 P3H1 PCOLCE P3H3 COL2A1 COL25A1 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 COL8A2 COL4A6 ADAMTS14 COL6A3 COL8A1 COL21A1 COL6A6 COL6A5 PPIB COL15A1 PCOLCE2 P4HB COL11A1 COL11A2 SERPINH1 COL19A1 COL28A1 CRTAP COL24A1 COL22A1 COL26A1 COL3A1 COL5A1 P4HA1 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 TLL2 TLL1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins LTA4H ALOX5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER CUL4A ERCC3 ERCC4 ERCC2 PIAS3 ERCC1 UBE2I UBE2N ERCC5 DDB2 CUL4B RBX1 PIAS1 PARP1 SUMO1 UBA52 SUMO3 RPA1 SUMO2 RPA2 UBE2V2 RPA3 UBB RNF111 UBC CDK7 PARP2 CETN2 USP45 RPS27A RAD23A GTF2H1 GTF2H2 CHD1L MNAT1 GTF2H3 RAD23B GTF2H4 DDB1 GTF2H5 XPA CCNH XPC TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway TRADD TRAF1 TAB3 TAB2 TAB1 RNF31 TRAF2 TNFAIP3 XIAP OTUD7B SPATA2 SHARPIN RIPK1 USP4 USP21 CHUK TNFRSF1A CYLD OPTN RBCK1 OTUD1 MAP3K7 BIRC2 BIRC3 IKBKB TNF IKBKG RACK1 USP2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity GRIA1 GRIP1 EPB41L1 MDM2 GRIA2 TSPAN7 MYO6 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 AKAP5 PRKCA AP2A1 DLG4 CAMK2B CAMK2D CACNG8 CAMK2A CACNG2 CACNG3 PRKCG CACNG4 CAMK2G PRKCB TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA BCKDHB DLD DBT GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation GAD1 SNAP25 GAD2 SLC6A12 SLC6A11 VAMP2 SLC32A1 SLC6A13 ABAT SLC6A1 ALDH5A1 RAB3A SYT1 STX1A CPLX1 HSPA8 RIMS1 DNAJC5 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport MB NGB CYGB DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate PRIM2 PRIM1 POLA1 POLA2 PCNA RPA1 RPA2 POLD3 POLD1 FEN1 POLD4 POLD2 DNA2 RPA3 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling PSMA5 SEM1 PSMA6 PSMA3 SYK PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 NFKB2 UBE2N PSMC4 TAB3 PPP3CA NFKBIA PSMC1 TAB2 PYCARD PPP3CB PSMC2 TAB1 PLCG2 CHUK PDPK1 CARD9 TRAF6 IKBKB AHCYL1 IKBKG PRKCD MALT1 CLEC7A IL1B BTRC UBE2D1 RELA UBA3 SKP1 NFATC2 NFATC1 CALM1 UBE2M FBXW11 NFKB1 MAP3K14 CASP8 NFATC3 UBA52 UBE2D2 MAP3K7 CUL1 PSMD12 PSMD11 UBB PSMD14 RELB PSMD13 UBC CDC34 PSMA7 PSMB6 RPS27A PSMD8 UBE2V1 CARD11 ITPR1 PSMB7 ITPR2 PSMB4 PSMD6 PSMB5 PSMD7 ITPR3 PSMB2 PSMB3 PSMD2 BCL10 PSMD3 PSMB1 PSMD1 ADRM1 PPP3R1 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing CALM1 PRKG2 KRAS GOLGA7 ARL2 NRAS BCL2L1 PDE6D FNTA FNTB ICMT PRKCQ ABHD17C ZDHHC9 USP17L2 ABHD17B ABHD17A LYPLA1 RCE1 HRAS ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage ASCC3 ALKBH3 ASCC1 ASCC2 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle VAV2 BCR PIK3R2 PIK3R1 CAV1 ABR PIK3CA NCKAP1L MCAM DOCK2 PAK1 SAMM50 CDC42 PGRMC2 BRK1 ARHGAP1 PAK4 GIT2 MTX1 EMD MPP7 DSG2 ESYT1 CDC42EP4 CDC42EP1 VAMP3 TIAM1 ARHGAP39 PIK3R3 NHS SLITRK5 SYDE1 LMAN1 ARHGAP42 ARHGAP21 ARHGDIA WASF2 LBR ERBIN CYBB RAB7A CYBA ARHGAP35 DOCK10 MCF2 LEMD3 IQGAP1 DEF6 BAIAP2L1 OPHN1 PLD2 TMPO VANGL1 TAOK3 DEPDC1B PAK2 ABI2 ARHGAP17 ITGB1 DOCK1 ABI1 EPHA2 GARRE1 RACGAP1 LAMTOR1 NCF1 ARHGAP26 NCF2 NCF4 VAPB CYFIP1 ARHGAP32 NCKAP1 ANKLE2 TRIO TFRC DIAPH3 SWAP70 STBD1 VRK2 RAC2 DOCK4 DOCK3 ARMCX3 GIT1 PREX1 VAV3 VAV1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 NPAS4 PLK2 FOS INS NR3C1 GEM MAPK1 MDM2 SYT10 MAPK3 TNRC6C MOV10 AGO3 RET AGO4 AGO1 RBFOX3 AGO2 TNRC6A TNRC6B CREBBP XPO1 ARNT2 REST ARNT BMAL1 CDK5 SRF IQSEC3 BDNF NAMPT CDK5R1 KCNIP3 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJA1 GJB2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules SULT1A1 SULT1C2 SULT2A1 SULT4A1 SULT1A4 SULT1A3 SULT1A2 ABHD14B TPST2 SULT1C4 TPST1 BPNT2 BPNT1 SULT6B1 SULT1E1 PODXL2 SULT1B1 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions PTPN6 YWHAE TLR1 TLR2 YWHAG HSP90AA1 PATJ RPS15 RPS14 GJA1 RPS17 RPS16 TBK1 RPS19 SNRPD2 RPS18 SNRPD1 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 RPS13 VPS39 RPS12 VPS18 HLA-H HLA-B HLA-C HLA-A RPS27A ATG14 HLA-F HLA-G HLA-E RPS4Y2 SAR1B PIK3R4 RPS4Y1 LARP1 VPS11 SFN VPS16 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 YWHAB IFNA8 MAP1LC3B TRIM4 IKBKE AKT1 JAK1 TOMM70 NUP214 RIPK2 SFTPD YWHAZ TYK2 IL17RC IL17RA SIKE1 TLR8 TLR7 RPS27L RNF135 RPS15A RPS3 RPS2 STAT1 IFNB1 STAT2 TJP1 NLRP12 STING1 IL17F FAU CRB3 IL17A GEMIN2 KPNA2 MAP3K7 RPS9 IFNA14 RPS7 RPS8 IFNA16 RPS5 VPS33A IFNA17 RPS6 VPS33B RPSA TUFM GEMIN4 SNRPG GEMIN5 GEMIN6 SNRPE UBE2V1 GEMIN7 MASP1 SNRPF GEMIN8 IFNA10 IFNAR1 SNRPB TKFC IRAK1 IRAK2 G3BP1 SMN2 G3BP2 NLRP3 IFNA21 UVRAG CAV1 MAVS UBE2N TAB3 TAB2 TAB1 NUP107 PALS1 NUP188 HSP90AB1 RPS4X YWHAQ MBL2 YWHAH NUP210 PDPK1 RPS3A IRF3 NUP93 TRAF3 CREBBP TRAF6 IRF7 PIK3C3 NUP205 POM121 BECN1 SEC23A AAAS DDX20 NOD1 NOD2 NUP160 POM121C NUP85 SEC24B TPR SEC24A NUP88 CNBP PTPN11 NUP155 VPS41 VPS45 NUP153 SEC24D SEC24C NUP62 NDC1 SEC13 NUP133 NUP50 NUP54 NUP42 NUP43 RAE1 RANBP2 NUP35 NUP37 CHUK ISG15 IFIH1 IKBKB TRIM25 IKBKG RIGI MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation FARS2 WARS2 LARS2 SARS2 NARS2 TARS2 IARS2 VARS2 PPA2 CARS2 EARS2 KARS1 RARS2 GARS1 AARS2 QARS1 PARS2 MARS2 DARS2 YARS2 HARS2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOB MAOA DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 POMT2 POMT1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation DLAT GCSH NFU1 DLST LIPT2 LIPT1 DBT LIAS FDX1 NDUFAB1 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2B ADRA2C ADRA2A DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis PIK3C3 MAPKAP1 BECN1 NFKBIA ATG14 RICTOR RIPK1 RETREG1 NFKBIB DAXX TAOK1 PRR5 MTOR PIK3R4 RPTOR MLST8 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis F2 F5 F8 F9 ADAMTS13 VWF ANO6 F10 F11 GP5 GP9 PROC PROS1 GGCX GP1BA TPST2 TPST1 FGB FGA GP1BB FGG TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 E2F5 HDAC1 CCNA2 RBL2 RBL1 RBBP4 TFDP1 TFDP2 LIN54 LIN37 LIN9 E2F4 LIN52 E2F1 MYBL2 CDK1 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR4 HTR6 HTR5A HTR2B HTR7 HTR2C HTR2A HTR1E HTR1F HTR1D HTR1A HTR1B SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer ADAM17 UBB NOTCH1 NEURL1B UBC DLL1 RPS27A JAG1 DLL4 NEURL1 MIB2 UBA52 MIB1 ADAM10 JAG2 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism FDX2 EXT2 NHLRC1 HPRT1 OPLAH CYP2R1 DBT CHST14 ACY1 KHK CHSY1 GAA LUM ADA APRT AHCY CYP17A1 SEMA5A POMT2 SPON2 IVD SEMA5B SPON1 THSD7B DPAGT1 POMT1 ADAMTSL1 MPI ADAMTS2 C1GALT1C1 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL3 ADAMTSL2 MUC12 MUC15 DOLK THSD7A ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP FMO3 THBS2 ADAMTS12 THSD1 THSD4 UBA52 ADAMTS10 ADAMTS15 FMOD ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 MUC16 NAGLU GALNT3 MUC17 MUC19 C1GALT1 GYG2 UBB GYG1 NOTCH1 SSPOP MUC5B MUC20 UBC MUC21 MOGS RPS27A LFNG SDC4 SDC2 SDC3 CYP4F22 GALK1 MPDU1 CYP26B1 ST3GAL3 DLD CYP26C1 MCCC2 NUS1 SDC1 SLC37A4 PC BTD AMN PCCA GALT HLCS MCCC1 PCCB ACACA HSPG2 BCAN SFTPD DPM1 DPM2 DPM3 ASS1 ADAMTS16 GALNS ADAMTS18 GALM MMACHC EPM2A ADAMTS4 CYP19A1 ADAMTS5 GPC1 ACAT1 GPC3 ADAMTS1 GPC2 GPC5 GNS CYP27A1 GPC4 ADAMTS8 MGAT2 GPC6 ADAMTS9 SRD5A3 B3GALT6 AGRN DCN MAOA TCN2 CYP27B1 SLC34A2 PAH ASL SLC25A15 ACAN CBLIF B4GAT1 DAG1 LARGE1 GYS2 POMGNT1 GYS1 AUH PAPSS2 GSS PPM1K TPMT ALDOB MMAA MMAB KERA MAN1B1 SLC26A2 PPP1R3C MMADHC CHST6 GNE NMRAL1 CYP21A2 CTSA UGT1A1 ABCD4 SGSH CHST3 HIBCH SFTPB SFTA3 SFTPA2 ALG8 SFTPC ALG9 CSF2RB ALG6 SFTPA1 ALG2 CSF2RA ALG3 ALG1 DCXR MC2R BCKDK B4GALT7 MTRR PRELP PNP DHDDS B3GAT3 POMC GGT1 IDUA HEXB MAT1A CYP2U1 NCAN HEXA BGN VCAN SLC35D1 HYAL1 GLB1 IDS G6PC1 CSPG5 CYP11A1 GUSB ARSB G6PC3 OGN TBXAS1 CD320 ECHS1 GBE1 CPS1 ARG1 UGT1A4 CYP7B1 OTC GALE SI GCLC CYP11B2 LCT CYP11B1 B4GALT1 GCLM MTR PGM1 NOTCH2 NOTCH3 BCKDHA NOTCH4 BCKDHB LMBRD1 MUC13 GFPT1 RPIA CYP24A1 ALG14 ALG13 ALG12 NAGS ALG11 OMD TALDO1 FDXR ADAMTS13 HGSNAT CYP1B1 RFT1 MMUT IDH1 CUBN NEU1 THBS1 ABCA3 PMM2 FDX1 EXT1 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS SHC1 NRAS RALA NTRK1 MAPKAPK2 MAPKAPK3 NGF SHC3 SHC2 MAPK12 RALGDS RALB MAPK13 SOS1 MAPK14 MAPK11 HRAS CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids GLYATL3 GLYATL2 GLYATL1 ACSM1 GLYAT ACSM2A ACSM5 ACSM4 ACSM2B POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins PRND TECTA TECTB CD52 BST1 RTN4RL2 IZUMO1R PIGC PIGB CEACAM7 NRN1L RTN4RL1 PIGA CEACAM5 CD109 PIGK LY6D PIGM SPACA4 PIGL PIGG LY6H PIGF GPLD1 PIGH NRN1 NTM TEX101 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 ART3 ART4 LYPD8 OTOA LY6G6C LY6G6D OPCML DPM1 NTNG1 DPM2 NTNG2 DPM3 NEGR1 CNTN5 GP2 LSAMP PLET1 PRSS41 FOLR2 XPNPEP2 RAET1G LYPD6B RAET1L ALPL CNTN3 CNTN4 MELTF ALPG MDGA2 ULBP2 MDGA1 RECK SPRN LY6E ALPI FCGR3B GPIHBP1 PIGS CPM LY6K PIGU PGAP1 PIGT PLAUR VNN1 PIGO VNN2 PSCA GPAA1 PIGN PIGP PIGZ PIGW MSLN PIGV PIGY PIGX PRSS21 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC6A5 SLC6A9 SLC17A6 SLC6A2 SLC17A7 SLC6A3 SLC6A4 SLC6A11 SLC25A18 SLC32A1 SLC6A13 SLC6A20 SLC6A1 SLC25A22 SLC6A19 SLC17A8 SLC6A15 SLC6A14 SLC22A2 SLC6A7 SLC22A1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors P2RY4 ADORA2B P2RY12 P2RY13 P2RY14 LPAR4 GPR17 P2RY10 P2RY6 P2RY11 P2RY2 ADORA2A LPAR6 P2RY1 ADORA3 ADORA1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB CASP10 TRIM25 IKBKG MAVS RIGI CASP8 RIPK1 FADD CHUK RNF135 TRIM4 IFIH1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation CBFB HEY2 GLI3 HDAC3 MAF ZNF521 MAPK1 SRC HDAC6 COL1A1 BGLAP MAPK3 SP7 AR RB1 WWTR1 YES1 UCMA HES1 YAP1 SATB2 ABL1 HEY1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane RPL24 RPL27 RPL26 RPL29 RPL28 SSR1 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A SERP1 SRPRA SRPRB RPL10 RPL12 RPL11 SRP19 RPL14 TRAM1 SRP54 RPL13 SSR4 RPL15 SSR2 RPL18 SSR3 RPL17 SRP9 RPL19 SRP72 SRP68 RPL27A RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 SEC61A2 SEC61A1 RPS26 SEC61G RPS25 SEC61B RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A RPL22L1 SEC11A SEC11C RPS27L RPS15A RPS3 RPS2 SPCS3 SPCS2 SPCS1 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 SRP14 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2AC14 TRIM28 ELK1 DYNC1LI1 DYNC1LI2 NUP107 NUP188 NUP210 NUP93 CHMP4C CHMP4B CHMP4A DYNC1I1 VPS28 H4C9 NUP205 POM121 TSG101 AAAS EGFR NUP160 POM121C NUP85 DYNLL2 TPR NUP88 H2AC20 NUP155 EZH2 NUP153 CHMP2B CHMP2A PML H2AC17 H2AC12 NUP62 H3C8 CBX1 NFKB1 NDC1 SEC13 NUP133 DYNLL1 H2AC25 VPS37C H2AC21 VPS37D VPS37A NCOR2 VPS37B NUP50 CHMP3 NUP54 CHMP6 NCOR1 CHMP7 DYNC1I2 VPS4A GPS2 H3C15 TBL1X NUP42 SUZ12 MVB12B H2BC9 MVB12A H2BC8 H2BC5 NUP43 H2BC3 H2BC1 RAE1 RANBP2 DYNC1H1 UBAP1 H2AC1 NUP35 VPS36 SNF8 VPS25 NUP37 H2AC8 H2AC6 H2AC7 TBL1XR1 HNRNPK DAXX H2BC18 NUP214 CEBPD H2BC26 H2BC21 CHMP1A EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ITGB1 H2BC11 HDAC3 RBBP4 RBBP7 H2AC19 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres LTBP4 LTBP2 LTBP3 LTBP1 TGFB2 TGFB3 ITGB3 MFAP5 BMP2 ITGB1 BMP10 MFAP4 MFAP3 ITGB5 MFAP2 ITGB8 ITGAV ITGB6 TGFB1 GDF5 EFEMP2 EFEMP1 BMP4 VTN FBLN1 FBLN2 FBLN5 ITGA8 BMP7 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 NAT2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2R1B CDKN2A PRDM1 SGK1 MDM2 MDM4 CHEK2 RICTOR DAXX UBA52 PRR5 PDPK1 AKT2 AKT3 MLST8 CCNG1 AKT1 MAPKAP1 TP53 UBB CDK2 CCNA2 UBC CCNA1 RPS27A USP7 RNF34 USP2 PPP2R1A ATM PHF20 RFFL MTOR PPP2R5C CDK1 PPP2CA PPP2CB PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism NT5C1A NT5C1B ITPA ADPRM GDA DNPH1 NUDT16 NUDT15 NT5C NT5E NT5C2 XDH PNP NUDT5 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades IRS1 PIK3R2 PIK3CB PIK3R1 JAK2 IL2RG MYC JAK3 FRS2 SHC3 PIK3CA PTPRA ITGB3 TNRC6C MOV10 SPTB AGO3 AGO4 AGO1 KSR1 AGO2 IL5RA CDC42 KSR2 FGB TNRC6A FGA TNRC6B FGG KRAS EGF ERBB2 EGFR SPTBN4 GRIN2B CDC42EP5 PPP1CB SPTBN5 CDC42EP3 PPP2R1A CDC42EP2 PRKACA GFRA3 VCL RASGRP3 IL6 SPTA1 PPP5C IQGAP1 PAK2 UBA52 BRAP ANGPT1 GOLGA7 SHC1 PSMD12 PSMD11 UBB TEK PSMD14 MRAS PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 LYPLA1 PSMB3 PSMD2 PSMD3 PSMB1 RASGRP1 PSMD1 RASGRP4 CDK1 ADRM1 DUSP5 PSMA5 DUSP2 SEM1 DUSP1 PSMA6 DUSP16 PAQR3 PSMA3 DUSP10 DUSP4 PSMC5 PTPN7 PSMA4 PSMC6 BCL2L1 DUSP6 DUSP7 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MAP3K11 DLG1 FOXO3 FOXO1 RASGRF2 PDGFRA YWHAB HSPB1 RAF1 FGF6 XPO1 SHOC2 JAK1 TYK2 MARK3 IL3RA SRC CSK PRKACG PRKACB MAP2K1 MAP2K2 RAP1A RBX1 MAPK1 IL2RA BRAF ZDHHC9 ABHD17C MAPK3 USP17L2 FGF1 FRS3 ABHD17B FGF4 ABHD17A RCE1 SHC2 FGF16 RALGDS FGF9 FGF18 FGF20 SPTBN2 SOS1 FGF23 KALRN LAMTOR2 SPTBN1 LAMTOR3 PTK2 TGFA MAPKAPK5 SPTAN1 SPRED3 SPRED2 PTPN3 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 CCND3 FYN ICMT IL2 PPP1CC IL3 FLT3LG PDGFB PAK1 DNAJB1 FLT3 PAK3 KLB RANBP9 PDGFRB FGF19 FGFR4 PTPN11 EPGN ARRB1 FN1 CALM1 PRKG2 DUSP8 DUSP9 NCOA3 FNTA FNTB WDR83 RGL3 RGL2 PEA15 RGL1 IL17RD RAPGEF2 SEPTIN7 CDC14A CDC14B RASGEF1A ETV4 IGF2BP1 MAPK6 MAPK4 ACTN2 CSF2RB CSF2RA ARL2 GRIN2D CSF2 DLG2 ITGA2B DLG3 CNKSR2 IRS2 CNKSR1 DLG4 RASGRF1 PEBP1 IL6R NEFL LRRC7 ARRB2 APBB1IP GRIN1 RAP1B HGF MET AREG FGF7 FGF22 MAPK12 FGF3 FGF10 PPP2R5B PPP2R5A PPP2R5D PPP2R5C JUN PPP2CA TLN1 PPP2CB PPP2R1B PPP2R5E IL5 PHB1 RAC1 NRG1 NRG2 EREG BTC IL2RB NRG3 NRG4 RET HBEGF KIT NRTN FGF2 NCAM1 PSPN GFRA2 GFRA4 ARTN VWF PDE6D ARAF GFRA1 CAMK2B CAMK2D CAMK2A GDNF CAMK2G RAG2 RAG1 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 CD86 PPP2R1B AKT1 CTLA4 PPP2R5E LYN CD80 FYN LCK PTPN11 PPP2R1A YES1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB AKT2 AKT3 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation CTC1 STN1 TEN1 PRIM2 PRIM1 ACD POLA1 TINF2 POLA2 TERF1 TERF2 POT1 TERF2IP O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation B3GNT7 B3GNT5 B3GNT4 B3GNT3 ST6GALNAC2 B3GNT2 ST6GALNAC3 ST6GALNAC4 GALNT1 SEMA5A POMT2 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL1 ADAMTS2 C1GALT1C1 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL3 ADAMTSL2 MUC12 MUC15 THSD7A ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 GALNT11 MUC2 GALNT14 ADAMTS19 GALNT13 ADAMTS17 GALNT16 MUC7 GALNT15 MUC4 GALNT18 MUC6 GALNT17 MUC16 GALNT10 GALNT3 POFUT4 MUC17 POFUT2 MUC19 POFUT3 C1GALT1 QTGAL SSPOP EMID1 MUC5B B3GALNT2 MUC20 GALNTL5 MUC21 ST6GAL1 GALNTL6 GALNT9 GALNT8 POMGNT2 B3GNT9 B4GALT6 B3GNT8 MMRN1 B3GNT6 B4GALT5 MMRN2 CHST4 GCNT1 MGAT5B GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT POMK ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 ADAMTS16 ADAMTS18 ADAMTS4 ADAMTS5 MUC13 ADAMTS1 ADAMTS8 ADAMTS9 ADAMTS13 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN THBS1 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation NANOG POU5F1 SOX2 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS SFTPB INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels KCNJ2 KCNJ3 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 GNG4 KCNJ10 GNG7 GNG8 KCNJ12 KCNJ9 KCNJ15 KCNJ16 ABCC8 GNG10 KCNJ11 GNG12 GNG11 GNG13 GNB2 ABCC9 GNB1 KCNJ14 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNJ1 KCNJ8 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome PSMA5 GLI1 SEM1 PSMA6 PSMA3 PSMC5 SUFU PSMA4 PRKACG PSMC6 PRKACB PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 NUMB UBA52 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC ITCH PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PRKACA PSMD3 PSMB1 PSMD1 SKP1 ADRM1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF5 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF2S3 EIF4A2 EIF4A1 RPS15A EIF2S2 EIF4G1 EIF2S1 RPS3 RPS2 RPS15 RPS14 EIF4E FAU EIF4B RPS17 RPS16 RPS19 RPS18 RPS9 RPS7 RPS8 RPS11 RPS5 RPS10 RPS13 RPS6 RPS12 RPSA RPS27A RPS4Y2 RPS4Y1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA TUT7 TUT4 PAN2 CNOT10 PAN3 TNKS1BP1 CNOT4 EIF4A3 CNOT6 CNOT6L CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 CNOT8 EIF4E EIF4B CNOT9 PAIP1 PABPC1 PARN EIF4A2 EIF4A1 EIF4G1 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k ALG1 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism SLC9A1 ABCC5 CHP1 LYVE1 HEXB HMMR HEXA CEMIP HYAL1 HYAL3 HAS1 HYAL4 STAB2 GUSB HAS3 SPAM1 HAS2 SLC17A5 HYAL2 CD44 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation CAPZB DYNC1LI1 DYNC1LI2 KIF23 KIF22 KIF2A KIF2C KIF2B CTNNBL1 CENPE KIF26A CAPZA1 CAPZA2 CTR9 RTF1 DYNLL2 ACTR1A PAF1 RELA RAB7A NFKB1 DYNLL1 JUND DCTN1 EXOSC10 UBA52 C1D IGHV3-23 MPHOSPH6 IGLV IGLV2-8 IGKV1-16 DYNC1I2 CD4 IGKV1-17 IGKV1-12 FOSB DCTN2 IGHV3-7 IGHV3-9 DCTN3 V2-11 IGHV3-30 V3-4 V3-3 V2-17 UBB V3-2 IGHV3-33 V2-15 IGKV1D-39 UBC V2-19 RFC1 IGKV1D-33 TRAC IGKV2D-28 IGKV4-1 RPS27A IGHV7-81 TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 V1-11 IGKV2D-30 HLA-DQA2 DYNC1H1 V1-16 HLA-DQA1 V1-13 HLA-DPA1 IGHV4-59 IGHV1-69 TRAV19 HLA-DRB5 HLA-DRB4 HLA-DPB1 IGLV2-11 POLD3 TRAV8-4 IGLV1-40 IGLV1-47 HLA-DRA HLA-DRB3 IGLV6-57 POLD2 IGLV2-14 HLA-DQB2 STAT3 IGLV1-44 IGKV3-15 HLA-DRB1 IGKV3-11 HLA-DQB1 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 DIS3 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 EXOSC7 IGHV3-53 EXOSC6 V4-2 EXOSC5 IGLC7 EXOSC4 V4-1 EXOSC9 ITGAL IGKV5-2 EXOSC8 IGKV1-5 EXOSC3 IGLC6 EXOSC2 EXOSC1 CTSV ITGA4 CTSS CTSL CTSK E2F5 CTSD CTSB PCNA PMS2 ICAM2 IFI30 BACH2 ICAM1 ICOSLG HOXC4 SLAMF6 MLH1 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO KIF3A ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 ACTR10 CD84 HLA-DOA HLA-DOB SUPT6H ZBTB17 MSH2 VCAM1 ITGB2 AFF4 TNFSF13B POLI SMARCB1 POLH IRF8 DCTN6 IGHG3 DCTN5 IGHG4 DCTN4 MLLT1 IGHG1 MLLT3 ACTB IWS1 IGHG2 RILP MCM3AP FCGR2B DPF1 DPF2 DPF3 BCL6 C3 SMARCC1 SMARCC2 CCNK CCNT2 CCNT1 PAXIP1 SUPT16H TCF3 GTF2F1 GTF2F2 EXO1 REV1 CREBBP MAD2L2 REV3L DYNC1I1 CR2 RFC5 SUPT4H1 SS18L1 RFC3 RFC4 SMARCA2 RFC2 SMARCA4 ELOA2 E2F7 SUPT5H E2F8 ASH2L CDK9 TAF4B ELL TAF7L ELOA NELFB ELOB NELFCD NELFA SS18 ELOC CTSA NCOA6 PAX5 NELFE ACTL6A MSH6 E2F2 AICDA CTDP1 TAF9 TAF1L POLR2A POLR2B POLR2C POLR2D POLR2G IGHM POLR2I TAF9B POLR2J IGHD TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 TCEA1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 NFKB2 ICOS KMT2D KMT2C OSBPL1A MAFK MAF SKIC8 IRF4 CR1 MEF2B STAT6 DPY30 PAGR1 BCL7A MYB CD79B BCL7C CD79A BATF BCL7B IL4 WDR5 KDM6A KIF5C TBP KIF5B KIF5A ARID1A KIFAP3 ARID1B KIF20A ITGB1 KLC1 CDC73 KLC4 CEBPA KLC3 KLC2 SMARCD1 KIF3B RACGAP1 SMARCD2 KIF3C SMARCD3 LEO1 KIF18A KIF4B KIF4A RBBP5 POLR2E POLR2F POLR2H POLR2K KIF11 POLR2L KIF15 SMARCE1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOXL CRAT ACOT8 CROT HSD17B4 AMACR ACOX2 ACOX3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions NRCAM DLG4 DLG1 CNTN2 NRP2 ANK1 DLG3 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade IRS1 PIK3R2 PIK3CB PIK3R1 JAK2 IL2RG JAK3 FRS2 SHC3 PIK3CA PTPRA ITGB3 SPTB KSR1 IL5RA KSR2 FGB FGA FGG KRAS EGF ERBB2 EGFR SPTBN4 GRIN2B PPP1CB SPTBN5 PPP2R1A GFRA3 VCL RASGRP3 SPTA1 PPP5C IQGAP1 UBA52 BRAP ANGPT1 GOLGA7 SHC1 PSMD12 PSMD11 UBB TEK PSMD14 MRAS PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 LYPLA1 PSMB3 PSMD2 PSMD3 PSMB1 RASGRP1 PSMD1 RASGRP4 ADRM1 DUSP5 PSMA5 DUSP2 SEM1 DUSP1 PSMA6 DUSP16 PAQR3 PSMA3 DUSP10 DUSP4 PSMC5 PTPN7 PSMA4 PSMC6 BCL2L1 DUSP6 DUSP7 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MAP3K11 DLG1 RASGRF2 PDGFRA YWHAB RAF1 FGF6 SHOC2 JAK1 MARK3 IL3RA SRC CSK MAP2K1 MAP2K2 RAP1A RBX1 MAPK1 IL2RA BRAF ZDHHC9 ABHD17C MAPK3 USP17L2 FGF1 FRS3 ABHD17B FGF4 ABHD17A RCE1 SHC2 FGF16 RALGDS FGF9 FGF18 FGF20 SPTBN2 SOS1 FGF23 LAMTOR2 SPTBN1 LAMTOR3 PTK2 TGFA SPTAN1 SPRED3 SPRED2 PTPN3 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 FYN ICMT IL2 PPP1CC IL3 FLT3LG PDGFB FLT3 KLB RANBP9 PDGFRB FGF19 FGFR4 EPGN ARRB1 FN1 CALM1 PRKG2 DUSP8 DUSP9 FNTA FNTB WDR83 RGL3 RGL2 PEA15 RGL1 IL17RD RAPGEF2 RASGEF1A ACTN2 CSF2RB CSF2RA ARL2 GRIN2D CSF2 DLG2 ITGA2B DLG3 CNKSR2 IRS2 CNKSR1 DLG4 RASGRF1 PEBP1 NEFL LRRC7 ARRB2 APBB1IP GRIN1 RAP1B HGF MET AREG FGF7 FGF22 MAPK12 FGF3 FGF10 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA TLN1 PPP2CB PPP2R1B PPP2R5E IL5 PHB1 NRG1 NRG2 EREG BTC IL2RB NRG3 NRG4 RET HBEGF KIT NRTN FGF2 NCAM1 PSPN GFRA2 GFRA4 ARTN VWF PDE6D ARAF GFRA1 CAMK2B CAMK2D CAMK2A GDNF CAMK2G METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host HBA2 HBB NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance ALDH2 SLC6A3 SLC6A4 TOMT COMT MAOA BCHE SLC22A2 ACHE SLC22A1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization RAB1A RAB1B CCNB2 RAB2A CCNB1 GOLGA2 GORASP2 BLZF1 MAPK1 GORASP1 PLK1 USO1 CDK1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling IL36RN MAP3K8 MAP2K4 UBE2N IL1RL2 TAB3 TAB2 TAB1 MAPK8 ALPK1 NLRX1 TOLLIP AGER TNIP2 S100A12 N4BP1 PTPN6 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 SQSTM1 PELI1 LRRC14 TRAF6 USP14 PELI3 PELI2 IL33 NLRC5 USP18 TIFA S100B SAA1 NOD1 IL1RN NOD2 ALOX5 IL1RL1 IL1R2 IL18 PTPN11 IL1A IL1B BTRC RELA SKP1 FBXW11 NFKB1 TRAF2 CASP8 UBA52 TBK1 IL1RAPL1 CUL1 PTPN9 PTPN5 PTPN2 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 PTPN7 PSMA4 PSMC6 APP PSMC3 PSMA1 NFKB2 PSMA2 PTPN12 PSMC4 NFKBIA PSMC1 PSMC2 CASP1 SIGIRR IRAK3 CHUK IKBKB TP53 IKBKG RIPK2 PTPN13 IL13 PTPN20 PTPN23 PTPN14 IL1R1 IL18BP PTPN18 IL18RAP IL4 CTSG MAP2K1 RBX1 IL36A IL36B PTPN4 MAP3K7 IL36G SMAD3 IL1F10 UBE2V1 GSDMD MAP3K3 IL37 MAP2K6 IL18R1 IRAK1 IRAK2 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors SP3 TP53 CDKN2A PIAS4 FOXL2 PIAS3 UBE2I MITF MTA1 TFAP2B TFAP2C MDM2 PIAS1 SUMO1 SUMO3 SUMO2 HIC1 TP53BP1 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia ARG1 DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC TCN2 CD320 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B DYNC1I1 CENPE NUF2 NUDC NUP160 YWHAE CEP57 NUP85 CETN2 DYNLL2 NEK9 CEP164 BIRC5 CCP110 NEK6 NEK7 B9D2 ACTR1A INCENP PCM1 AURKB SPC24 TUBA1A PPP2R1A SPC25 ERCC6L CNTRL CEP250 NEK2 ZWILCH PRKACA CENPA CEP290 NINL YWHAG CENPC CDK5RAP2 OFD1 HSP90AA1 CEP135 CDCA5 KNTC1 PDS5B PDS5A WAPL TUBB CEP131 CENPT HAUS4 HAUS3 CENPU CSNK1D HAUS6 SGO1 SEC13 HAUS5 CSNK1E SGO2 SMC3 TUBG1 NUP133 DYNLL1 RAD21 CKAP5 TUBA4A CENPF HAUS2 STAG1 HAUS1 AKAP9 STAG2 CENPH RANGAP1 CEP63 PMF1 SMC1A MAPRE1 CENPI SFI1 TAOK1 CENPK PAFAH1B1 CENPL SDCCAG8 CENPM DYNC1I2 CPAP DCTN2 SSNA1 CENPN DCTN3 CENPO CENPP CCNB2 CENPQ CCNB1 NUMA1 CENPS TUBG2 MZT2B HAUS8 PRKAR2B MZT2A NME7 HAUS7 TUBGCP2 CEP70 MZT1 CEP72 TUBGCP5 CEP192 TUBGCP6 NUP43 TUBGCP3 PCNT TUBGCP4 CEP76 CLASP1 CEP78 RANBP2 PLK4 FIRRM DYNC1H1 ODF2 CEP152 NDE1 PLK1 CLIP1 TUBB4B TUBB4A NEDD1 MAD1L1 ALMS1 CDK1 CEP41 CEP43 NUP37 SMC4 SMC2 NCAPG NCAPH NCAPD2 ITGB3BP NDC80 RPS27 BUB1 CLASP2 XPO1 SPDL1 CSNK2A1 NSL1 CSNK2A2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C CSNK2B PPP2CA PPP2CB PPP2R1B PPP2R5E KNL1 ZW10 DSN1 BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 KIF18A EML4 NDEL1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing PCSK6 PCSK5 FURIN NGF GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis GPC1 GPC3 GPC2 GPC5 NCAN GPC4 BGN GPC6 VCAN FAM20B SDC1 B3GALT6 CSPG5 DCN AGRN HSPG2 BCAN UXS1 PXYLP1 B4GALT7 SDC4 SDC2 XYLT2 SDC3 XYLT1 B3GAT3 B3GAT2 B3GAT1 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) RPS6KA5 SYK NRAS FYN UBE2N TAB3 TAB2 TAB1 CLEC10A PLCG2 PAK1 PDPK1 CREBBP TRAF6 PAK3 AHCYL1 IL1B BTRC PRKACA UBE2D1 RELA UBA3 SKP1 CALM1 UBE2M FBXW11 MUC12 NFKB1 MUC15 MAP3K14 MUCL1 MUC3A MUC5AC MUC3B CASP8 PAK2 NFATC3 UBA52 UBE2D2 MUC1 MUC2 MUC7 MUC4 MUC6 CUL1 MUC16 MUC17 PSMD12 MUC19 PSMD11 UBB PSMD14 MUC5B PSMD13 MUC20 UBC CD209 MUC21 CDC34 PSMA7 PSMB6 RPS27A PSMD8 CARD11 ITPR1 PSMB7 ITPR2 PSMB4 PSMD6 PSMB5 PSMD7 ITPR3 PSMB2 PSMB3 PSMD2 BCL10 PSMD3 PSMB1 PSMD1 ADRM1 PPP3R1 EP300 PSMA5 SEM1 PSMA6 LYN PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 NFKB2 PSMA2 PSMC4 NFKBIA PPP3CA PSMC1 PYCARD PPP3CB PSMC2 CHUK CARD9 RAF1 IKBKB CLEC4A CLEC4C CLEC4D PRKCD CLEC4E IKBKG CLEC7A MALT1 CLEC6A NFATC2 MUC13 NFATC1 PRKACG PRKACB ICAM2 ICAM3 MAP3K7 RELB FCER1G UBE2V1 HRAS GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A EIF2S3 EIF4A2 EIF4A1 EIF2S2 RPL10 EIF2S1 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 EIF4E EIF4B RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 EIF5 RPS26 RPS25 EIF5B RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A EIF1AX RPL22L1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF4G1 RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 PELO RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L RPL37A RPL23A RPL36A RPL35A RPL22L1 RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 ABCE1 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A RPL37 RPL39 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi ST3GAL3 NOTCH1 FURIN B4GALT1 TMED2 LFNG MFNG NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG ATP2A3 ST3GAL6 ATP2A2 RAB6A ATP2A1 ST3GAL4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling CBFB LIFR RUNX1 IL3 ELF1 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes AMN CUBN PRSS1 ABCD4 LMBRD1 CTRB2 TCN1 CTRB1 CBLIF PRSS3 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA ACADM MECR HADHB HADHA HADH ECHS1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors F2 PROC BGLAP F7 PROS1 GGCX F9 GAS6 PROZ F10 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts NCOA1 NCOA2 SLC51A SLCO1B1 SLC51B NR1H4 SLCO1B3 ALB FABP6 BAAT STARD5 SLCO1A2 RXRA ABCB11 SLC10A1 SLC10A2 SLC27A5 ABCC3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR NRAS PIK3R1 FGFRL1 MKNK1 SPRY2 FRS2 PIK3CA GTF2F1 GTF2F2 TIAL1 PTBP1 FGF6 RBFOX2 HNRNPH1 ESRP2 KLB ESRP1 GAB1 HNRNPA1 TIA1 HNRNPM TGFBR3 PLCG1 GIPC1 FGF19 FGFR4 PTPN11 PPP2R1A FGFBP1 FGF7 FGFBP2 FGFBP3 FGF22 FGF3 FGF10 PPP2CA PPP2CB ANOS1 NCBP1 NCBP2 MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 UBA52 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HNRNPF CBL FGF2 GALNT3 POLR2A UBB POLR2B POLR2C POLR2D UBC POLR2G POLR2I RPS27A POLR2J POLR2E POLR2F POLR2H SPRED2 SPRED1 POLR2K FLRT2 POLR2L HRAS FLRT3 FLRT1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex APC PPP2R1B PPP2R5E CSNK1A1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases ASCC3 ALKBH3 ASCC1 ALKBH2 FTO ALKBH5 ASCC2 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFSF11 TNFRSF6B EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF1B EDAR LTA TNFRSF25 TNFRSF11B TNFRSF1A TNFRSF17 TNFSF18 TNFSF14 TNFSF15 CD70 TNFRSF9 TNFSF6 TNFSF4 TNFSF9 CD27 TNFSF8 TNFRSF14 TNFSF13B TNFSF13 TNFRSF18 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A FARP2 PLXNA1 RRAS PLXNA2 PLXNA3 RAC1 FYN FES PIP5K1C NRP1 RND1 PLXNA4 TLN1 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) SLC6A19 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions ERLIN2 FGFR1 BAG4 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB CALM1 CAMK2B CAMK2D CAMK2A CAMK4 KPNA2 CAMK2G CAMKK1 CAMKK2 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition CDT1 CDC6 JAK2 CCND3 CCND2 MYC CDKN2D CDKN2C MYBL2 DHFR CCND1 CABLES1 WEE1 RBL2 RBL1 PPP2R2A PPP2R1A E2F4 CDC7 SKP1 CDKN2A UBA52 E2F2 AKT2 AKT3 CDKN2B CCNE2 CCNE1 CUL1 PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC POLE PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 PSMA5 SEM1 TOP2A PSMA6 POLE4 LYN PSMA3 PSMC5 PSMA4 CDC25A PSMC6 POLE2 PRIM2 PSMC3 PSMA1 PRIM1 POLE3 PSMA2 POLA1 PSMC4 POLA2 PSMC1 PSMC2 DYRK1A CKS1B PPP2R3B SKP2 MAX CDKN1C MCM10 DBF4 RPA4 ABL1 CDK6 AKT1 RRM2 CDK7 TFDP1 TYMS TFDP2 MNAT1 CDKN1A E2F1 E2F3 PPP2CA PPP2CB CDC45 MCM7 PPP2R1B MCM8 MCM3 CDKN1B MCM4 MCM5 E2F5 MCM6 MCM2 E2F6 PCNA LIN54 LIN37 LIN9 LIN52 RPA1 RPA2 RPA3 PTK6 CDK4 FBXO5 CDK2 CCNA2 HDAC1 CCNA1 TK1 RBBP4 RB1 CCNH GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF CALM1 VCL NRAS PHB1 JAK2 ARRB2 MAP2K1 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 ITGB3 MAP3K11 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG BRAP RAP1B KRAS VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 CAMK2B CAMK2D PEBP1 CAMK2A CSK HRAS CAMK2G TLN1 FN1 FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct WFDC2 PLAC8 MECOM HOXA6 EMX2 CTNNB1 OSR1 NPNT PAX2 RET BMP4 PAX8 GATA3 LHX1 PCDH19 HOXB4 FGF2 ID4 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR PDHX DLAT PDHA2 PDHA1 PDHB DLD FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing NCBP1 NCBP2 GTF2F1 GTF2F2 TIAL1 HNRNPF PTBP1 RBFOX2 HNRNPH1 ESRP2 ESRP1 POLR2A HNRNPA1 POLR2B TIA1 HNRNPM POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F POLR2H POLR2K POLR2L DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses DDX3X MAVS C1QA APOA1 C4B_2 STAT2 CLU STING1 HSP90AB1 C1S MBL2 C4A CDC73 UBR4 IFIH1 IKBKE TRIM25 CGAS EXOC1 LEO1 CTR9 RTF1 SKIC8 RBM10 C4BPA C4BPB PAF1 CLEC5A VTN HSP90AA1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RPL24 EIF4A3 RPL27 CASC3 RPL26 MAGOH RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A RBM8A UPF3B MAGOHB RNPS1 PPP2R2A PPP2R1A RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 NCBP1 RPL27A NCBP2 RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF1 PNRC2 RPL37A GSPT2 GSPT1 UPF3A RPL36A UPF2 ETF1 RPL35A PABPC1 RPL22L1 RPS27L PPP2CA DCP1A EIF4G1 RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors CALM1 PRKG2 COQ8B COQ8A ACO1 DHFR PDSS2 AKT1 PDSS1 NOS3 HPDL SPR GCH1 IDH1 PTS GCHFR COQ9 COQ7 STARD7 COQ6 COQ5 COQ4 COQ3 COQ2 HSP90AA1 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling UBB UBC MKNK1 RPS27A SPRY2 PTPN11 MAPK1 FRS2 BRAF PPP2R1A MAPK3 FGF1 FGF4 FGF16 UBA52 FGF9 FGF18 FGF20 FGF23 PPP2CA PPP2CB CBL FGF2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping ERCC3 ERCC2 NCBP1 NCBP2 GTF2F1 GTF2F2 RNMT RAMAC POLR2A POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 RNGTT GTF2H4 POLR2E GTF2H5 POLR2F POLR2H SUPT5H CCNH POLR2K POLR2L DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models PRDX2 GOLGA2 CDC25A PRDX1 APP CDC25B YWHAE LMNB1 CDK5 FASLG CAPNS1 CAPNS2 CDC25C CAPN2 CAPN1 CAST FOXO3 SOD2 CDK5R1 JUN BCL2L11 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane PIK3R2 PIK3CB SBF2 PIK3R1 PIP5K1A PIP5K1B PIK3CA PIP5K1C BMX PTEN MTM1 MTMR14 PTPN13 OCRL RAB4A SYNJ2 PI4K2B SYNJ1 RUFY1 PIK3R3 RAB5A PIK3R6 PIK3R5 PIK3C2G PIK3C2A PIK3C2B MTMR1 PI4K2A MTMR2 INPPL1 MTMR3 INPP4A MTMR8 INPP4B MTMR9 MTMR6 PIK3CD PIK3CG INPP5D INPP5J INPP5K PIP4K2A RAB14 ARF1 PIP4K2B PIP4K2C PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n RFT1 DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism ABCD4 MTR CBLIF MMUT MCCC2 PC AMN MTRR BTD MMACHC CUBN PCCA HLCS MCCC1 MMAA PCCB MMADHC MMAB ACACA LMBRD1 TCN2 CD320 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection RPL24 RPL27 RPL26 RPL29 RPL28 KPNA7 KPNA4 KPNA5 NUP107 KPNA3 NUP188 RPL10L RPL10A RPS4X KPNA1 RPL41 NUP210 RPS3A GTF2F1 RPL3L GTF2F2 NUP93 RPL23A TGFB1 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 EIF2AK2 NUP153 HSP90AA1 RPL10 NUP62 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 NDC1 RPL19 SEC13 NUP133 RPL27A RPL13A RPS15 PABPN1 RPS14 NUP50 RPS17 UBA52 NUP54 RPS16 RPS19 RPS18 RPS11 RPS10 POLR2A RPS13 POLR2B NUP42 RPS12 POLR2C POLR2D IPO5 CALR GRSF1 POLR2G RPLP1 DNAJC3 NUP43 RPLP0 POLR2I RPS27A POLR2J RAE1 RANBP2 RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 NUP35 RAN NUP37 MLKL RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A ISG15 XPO1 NUP214 RPL36A RPL35A CLTC CLTA RPL22L1 CANX SLC25A6 KPNB1 RPS27L HSPA1A RPS15A RPS3 RPS2 PARP1 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 KPNA2 CPSF4 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 GBP1 RPL37 RPL39 POLR2E POLR2F POLR2H RPL21 RPL23 RPL22 POLR2K POLR2L UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE UNC93B1 TLR3 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 EP300 CRTC1 NCOA1 NCOA2 NPAS2 NCOA6 CLOCK MED1 MEF2C RORA ATF2 TBL1XR1 SIRT1 HELZ2 RXRA NR1D1 NCOR1 NRIP1 PPARGC1A PPARA TGS1 CREBBP TBL1X HDAC3 SMARCD3 CHD9 BMAL1 RORC RORB CARM1 CRTC2 CRTC3 RAI1 MEF2D G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints CDC6 H2BC12L UBE2N RAD9B YWHAQ RAD9A YWHAH UBE2V2 EXO1 CLSPN H4C9 TOPBP1 WEE1 RFC5 RFC3 RFC4 RFC2 YWHAE RBBP8 H2AX CDC7 YWHAG RAD50 BRCC3 BABAM1 BABAM2 GTSE1 UIMC1 ABRAXAS1 RNF8 UBA52 CCNB2 PSMD12 CCNB1 PSMD11 UBB NSD2 PSMD14 PSMD13 UBC H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 SFN TP53BP1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PIAS4 PSMA4 CDC25A PSMC6 RNF168 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 MDC1 PSMC2 KAT5 CHEK2 CHEK1 MCM10 DBF4 HUS1 PKMYT1 YWHAB DNA2 RHNO1 TP53 YWHAZ ATRIP BARD1 RAD17 ATM ATR BRCA1 H2BC26 CDC45 MCM7 MCM8 H2BC21 MCM3 HERC2 RMI2 MCM4 MCM5 MCM6 RMI1 MCM2 TOP3A H2BC17 WRN H2BC12 H2BC13 H2BC14 H2BC15 RPA1 H2BC11 RPA2 RPA3 RAD1 CDK2 CCNA2 MRE11 CCNA1 H3-4 NBN CDC25C BRIP1 BLM ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway IL36RN IL36G IL36A IL36B IL1F10 IL1RL2 M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase DYNC1LI1 DYNC1LI2 KIF23 CDCA8 SKA1 SKA2 KIF2A KIF2C PTTG1 KIF2B CENPE LPIN1 LPIN2 LPIN3 NUF2 EMD NUDC YWHAE CEP57 CETN2 DYNLL2 CEP164 CCP110 PPP2R2A ACTR1A INCENP PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 ANAPC15 PRKACA ANAPC16 CENPA UBE2D1 CEP290 ANAPC10 NINL CENPC YWHAG ANAPC11 CDC23 CDK5RAP2 CDC26 OFD1 CDC27 VRK1 HSP90AA1 LEMD2 CDCA5 CEP135 CTDNEP1 CNEP1R1 ANAPC7 PDS5B PDS5A UBE2C WAPL TUBB CENPT CEP131 UBE2E1 ESPL1 HAUS4 CENPU HAUS3 CSNK1D UBE2S CDC16 LMNB1 HAUS6 ANAPC4 HAUS5 CSNK1E ANAPC5 SMC3 TUBG1 ANAPC1 DYNLL1 ANAPC2 RAD21 CKAP5 CENPF TUBA4A HAUS2 STAG1 HAUS1 AKAP9 STAG2 CENPH CEP63 MAPRE1 CENPI SMC1A SFI1 UBA52 TAOK1 CENPK PAFAH1B1 CENPL SDCCAG8 CENPM DYNC1I2 CPAP DCTN2 SSNA1 CENPN DCTN3 CENPO CENPP CENPQ CCNB2 CENPS PSMD12 CCNB1 PSMD11 UBB HAUS8 PRKAR2B PSMD14 PSMD13 HAUS7 UBC CEP70 CEP72 CEP192 PSMA7 PCNT PSMB6 RPS27A PSMD8 CEP76 CLASP1 CEP78 PSMB7 PLK4 PSMB4 PSMD6 DYNC1H1 FIRRM PSMB5 ODF2 PSMD7 CEP152 PSMB2 NDE1 PLK1 PSMB3 PSMD2 TUBB4B CLIP1 PSMD3 TUBB4A PSMB1 NEDD1 PSMD1 ALMS1 MAD1L1 CDK1 CEP41 CEP43 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 GOLGA2 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 NDC80 RPS27 PSMC2 XPO1 SPDL1 TNPO1 NUP214 PRKCA SET NSL1 KPNB1 MAPK1 KNL1 ZW10 DSN1 RCC2 BUB1B CDC20 FBXO5 ZWINT BUB3 AHCTF1 MAD2L1 KMT5A RB1 NDEL1 H2AC19 H2AC14 H2BC12L NUP107 NUP188 MIS12 RCC1 PPP1CC BANF1 NUP210 NUP93 CHMP4C CHMP4B DYNC1I1 CHMP4A H4C9 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NEK9 BIRC5 NUP88 H2AC20 NEK6 B9D2 NEK7 SPC24 NUP155 AURKB SPC25 H2AX ERCC6L NUP153 ZWILCH CHMP2B CHMP2A NUP62 H3-3B KNTC1 LBR H3C8 NDC1 SEC13 SGO1 SGO2 NUP133 TUBB6 TUBB3 TUBB1 RANGAP1 PMF1 NUP50 H2AJ CHMP3 NUP54 CHMP6 CHMP7 TUBA4B VPS4A H3C15 NUMA1 TUBG2 MZT2B NUP42 MZT2A NME7 H2BC9 TUBGCP2 H2BC8 MZT1 H2BC5 TUBGCP5 TUBGCP6 NUP43 H2BC3 TUBGCP3 TUBGCP4 H2BC1 RAE1 RANBP2 TUBB8 SPAST IST1 TUBB8B CC2D1B TUBA8 TUBA1C TUBA1B NUP35 H2AB1 RAN TUBB2B RAB2A TUBB2A GORASP2 NUP37 BLZF1 SMC4 H2AC8 SMC2 NCAPG H2AC6 NCAPH H2AC7 UBE2I NCAPD2 ITGB3BP TUBAL3 TUBA3E TUBA3D TUBA3C SUMO1 BUB1 CLASP2 ARPP19 NCAPH2 NCAPG2 NIPBL ENSA SIRT2 NCAPD3 MAU2 MASTL MCPH1 PPP2R2D CSNK2A1 CSNK2A2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C CSNK2B PPP2CA H2BC26 PPP2CB PPP2R1B H2BC21 PPP2R5E LEMD3 H2BC17 H2BC12 H2BC13 KIF20A H2BC14 H2BC15 H2BC11 RAB1A RAB1B H3-4 KIF18A ANKLE2 GORASP1 EML4 USO1 PRKCB H2AZ2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels KCNS1 KCND1 KCNS2 KCNQ5 KCND2 KCNA10 KCND3 KCNB1 KCNQ4 KCNG2 KCNQ1 KCNG1 KCNC2 KCNG3 KCNG4 KCNC1 KCNQ2 KCNA1 KCNQ3 KCNC3 KCNA2 KCNC4 KCNAB2 KCNA3 KCNA4 KCNA6 KCNA7 KCNA5 KCNV1 KCNV2 KCNH1 KCNF1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNB2 KCNH8 KCNAB1 KCNS3 KCNAB3 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 RAD51C H4C9 H2AC20 RBBP8 ATM H2AX SPO11 RAD50 BRCA1 H2BC26 TEX15 RAD51 MSH4 MSH5 H2BC21 H3-3B DMC1 PSMC3IP H3C8 MND1 TOP3A MLH3 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ RPA1 H2BC11 RPA2 MLH1 RPA3 H3C15 CDK4 CDK2 MRE11 H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 PRDM9 BRCA2 H2BC1 FIRRM FIGNL1 BLM H2AC19 H2AB1 H2AZ2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex SMARCD1 BCL7C SMARCD2 BCL7B SS18L1 SS18 SMARCD3 BICRAL SMARCA2 BICRA BRD9 ACTL6A SMARCA4 SMARCC1 SMARCC2 ACTB BCL7A SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function BRAF SHOC2 PPP1CC MRAS YWHAB RAF1 PPP1CB ARAF MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins FURIN PPP1CB SPCS3 SPCS2 SEC11A SPCS1 SEC11C CSNK2A1 PPP1CC CSNK2A2 PPP1CA KPNB1 CSNK2B XPO1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption RSC1A1 SLC2A5 SLC5A1 SLC2A2 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events RPS6KA3 LRRC7 PPM1E RPS6KA2 NRAS RPS6KA1 PPM1F GRIA1 GRIA2 GRIA3 GRIA4 DLG1 PDPK1 PRKAB1 RASGRF2 KIF17 GRIN1 APBA1 GRIN2A PRKAG2 CAMK1 CAMKK1 CAMKK2 PRKAA1 GRIN2B SRC PRKX PRKACA PRKAG1 PRKAG3 CALM1 PRKACG PRKAA2 RAC1 PRKACB NRG1 MAPK1 PRKAR1B MAPK3 PRKAR1A KPNA2 CAMK4 ADCY1 ADCY8 RPS6KA6 ACTN2 CASK PRKAR2A LIN7A LIN7C PRKAR2B GRIN2C GRIN2D GRIN3B DLG2 GRIN3A DLG3 NBEA DLG4 RASGRF1 CAMK2B PRKAB2 CAMK2D GIT1 CAMK2A NRGN HRAS LIN7B CAMK2G NEFL GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CA1 RALA TCP1 PITPNA BOLA2B LMNB1 CNN2 HNRNPDL CFL1 STAT4 GSTA2 PAK2 IL10 SERPINB2 ANXA2 MSN MIF SOD2 CDC42 SOD1 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 PPIA RAP1B SNRPA1 LCP1 TALDO1 CAPZA1 AIP ARF1 RPLP0 GSTO1 HSPA9 MTAP NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression B2M AP1G1 AP1S2 AP1S1 AP1S3 PACS1 AP1B1 AP1M2 HLA-A AP1M1 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants APC PPP2R1B PPP2R5E CSNK1A1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells KCNN2 KCNMB1 CHRNA9 KCNMA1 CHRNA10 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport TMEM126A MT-CO2 MT-CO3 NDUFAF8 TMEM126B NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 SLC25A22 NDUFAF1 NDUFA9 NDUFA8 COX7B NDUFA7 NDUFA6 UQCR11 COX7C NDUFA3 UQCR10 NDUFA2 ETFDH NDUFA1 COX8A SFXN4 COX8C MT-ND6 MT-ND4 MT-ND5 MT-ND2 TMEM186 MT-ND3 MT-ND1 COA3 COX5B COX5A COA1 OXA1L TIMM21 TMEM177 COX7A2 COX7A1 COX6C HSPA9 UQCRC1 UQCRC2 NDUFAB1 TACO1 COA5 COX6A1 COX6A2 SURF1 TIMMDC1 SDHC SDHD SDHA HSCB COX6B2 SDHB COX6B1 COX19 NDUFB10 COX16 COX15 NDUFB11 COX18 COX17 ACAD9 HIGD1A HIGD1C ECSIT COX11 NUBPL COX14 HIGD2A COX20 UQCRB TMEM223 UQCRH DMAC1 DMAC2 PET117 CYC1 NDUFV3 NDUFV2 UQCRQ NDUFV1 PET100 MDH1 MDH2 MT-CYB LETM1 LYRM2 CYCS ETFA LYRM4 ETFB TTC19 LYRM7 UQCRFS1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 FXN SMIM20 NDUFS4 NDUFS3 NDUFS2 CMC1 NDUFS1 FOXRED1 GOT1 COX7A2L GOT2 UQCRHL NDUFA13 NDUFA11 NDUFA12 NDUFA10 COX4I1 COX4I2 COXFA4 NDUFC2 BCS1L NDUFC1 PYURF SLC25A18 MT-CO1 TRAP1 UQCC3 UQCC2 RAB5IF SLC25A12 UQCC1 COQ10B SLC25A11 COQ10A UQCC6 UQCC5 SLC25A13 NDUFB9 HCCS NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 SCO1 NDUFB2 NDUFB1 SCO2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) H2BC12L UBE2N RAD51B RAD51C RAD9B RAD9A LIG1 UBE2V2 EXO1 CLSPN H4C9 TOPBP1 RFC5 RFC3 RFC4 RFC2 RBBP8 H2AX RAD50 BRCC3 BABAM1 BABAM2 UIMC1 ABRAXAS1 RNF8 UBA52 RNF4 UBB NSD2 POLK UBC POLE H2BC9 RFC1 H2BC8 H2BC5 MUS81 H2BC3 BRCA2 RPS27A RAD51AP1 H2BC1 SLX4 EME1 EME2 FIRRM FIGNL1 GEN1 SLX1B XRCC2 XRCC3 PALB2 SPIDR POLD3 POLD4 POLD2 TP53BP1 SEM1 POLE4 PIAS4 ERCC4 POLE2 RNF168 ERCC1 UBE2I POLE3 MDC1 RTEL1 RAD52 KAT5 CHEK1 HUS1 SUMO2 POLD1 ABL1 DNA2 RHNO1 ATRIP BARD1 SIRT6 RAD17 ATM ATR BRCA1 H2BC26 RAD51 H2BC21 HERC2 RMI2 RMI1 PPP4R2 TOP3A TIPIN TIMELESS PPP4C RAD51D H2BC17 PCNA WRN H2BC12 H2BC13 H2BC14 H2BC15 RPA1 H2BC11 RPA2 RPA3 RAD1 CDK2 CCNA2 MRE11 CCNA1 H3-4 NBN BRIP1 BLM POLH ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation H2AC14 EP300 PBX1 H2BC12L CNOT6 H2AC8 H2AC6 H2AC7 KMT2D KMT2C PAXIP1 RXRA CNOT9 RARA HOXA2 CREBBP H4C9 YY1 PAX6 H2AC20 EZH2 H2AX DPY30 ASH2L PAGR1 H2BC26 JUN RARG H2BC21 H3-3B H3C8 WDR5 NCOA6 EGR2 NCOA3 KDM6A RARB EED HOXA3 HOXA1 H2BC17 PKNOX1 HOXA4 H2BC12 PIAS2 H2BC13 H2BC14 HOXB3 H2BC15 HOXB2 HOXB1 H2AJ HOXD1 MEIS1 AJUBA MAFB NCOR1 H2BC11 HOXC4 HOXD4 HOXD3 ZNF335 PCGF2 H3C15 POLR2A HDAC3 POLR2B CTCF POLR2C POLR2D SUZ12 H2BC9 H2BC8 POLR2G H2BC5 POLR2I H2BC3 RBBP4 POLR2J H2BC1 RBBP5 POLR2E POLR2F POLR2H RBBP7 H2AC19 POLR2K POLR2L H2AB1 HOXB4 H2AZ2 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling ALK PTN PTPRZ1 MDK SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions NRAS JAK2 ARRB2 AGK QKI ITGB3 TRAK1 APBB1IP KSR1 KDM7A KSR2 YWHAB FGB FGA RAF1 FGG RAP1B ESRP1 FAM114A2 MARK3 SRC ARRB1 ZC3HAV1 CSK AP3B1 TLN1 FN1 CALM1 FXR1 VCL MAP2K1 MAP2K2 IQGAP1 LMNA RAP1A MAPK1 BRAF AKAP9 MAPK3 KIAA1549 ATG7 FAM131B TRIM24 VWF ITGA2B CLCN6 ARAF AGTRAP CNKSR2 CNKSR1 MPRIP CAMK2B AGGF1 PEBP1 SND1 CAMK2D CAMK2A PAPSS1 HRAS CAMK2G TENT4A BCL2L11 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants FZD5 FZD4 RNF43 FZD6 FZD8 WNT3A LRP5 LRP6 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling CALM1 RPS6KA3 LRRC7 NRAS RPS6KA2 RPS6KA1 MAPK1 MAPK3 DLG1 PDPK1 RASGRF2 RPS6KA6 ACTN2 GRIN1 GRIN2D DLG2 DLG3 GRIN2B DLG4 CAMK2B RASGRF1 CAMK2D CAMK2A HRAS CAMK2G NEFL NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways BCL2 NLRP3 BCL2L1 APP NLRC4 MEFV NFKB2 UBE2N PANX1 TAB3 P2RX7 TAB2 PYCARD TAB1 PSTPIP1 AIM2 CASP1 TXNIP HSP90AB1 NLRP1 TXN SUGT1 CHUK CARD9 TRAF6 CASP2 IKBKB IKBKG RIPK2 NOD1 NOD2 CASP4 MAPK12 RELA MAPK14 MAPK11 NFKB1 TNFAIP3 CASP8 HMOX1 CYLD MAPK13 MAP3K7 BIRC2 BIRC3 ITCH UBE2V1 AAMP CASP9 MAP2K6 IRAK1 IRAK2 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin FDX2 FDXR FDX1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs ZBP1 IKBKB DTX4 RIPK3 DHX9 IKBKG NFKB1 NFKB2 NFKBIA TICAM1 RIPK1 MYD88 NFKBIB CHUK NKIRAS1 TBK1 NKIRAS2 RELA IRF3 TLR3 NLRP4 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis BCL2 HINT1 HDAC1 DICER1 POU3F2 BCL2A1 TRPM1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 BIRC7 TNRC6A TNRC6B SIN3A STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants NOX4 STAT5A BCL2L1 CDKN1A STAT5B GRB2 PIM1 FLT3 GAB2 PTPN11 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines H3C8 WDR5 NFKB1 SMYD3 NFKB2 EED PRDM16 SETDB2 KMT2D SUV39H2 SETD2 KMT2A SETD3 KMT2C SETD6 KMT2B SETD7 AEBP2 ASH1L H4C9 SETDB1 DOT1L H3C15 NSD3 SETD1B NSD1 MECOM NSD2 SETD1A SUZ12 KMT5A PRDM9 RBBP4 RBBP5 EZH2 SUV39H1 KMT5B DPY30 ASH2L RBBP7 SMYD2 EHMT2 RELA KMT5C EHMT1 ATF7IP DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells FGF10 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis CLVS1 DNAJC6 HGS APP GNS BLOC1S1 VAMP2 CLTB AP1M2 TXNDC5 AP1M1 AP4B1 VAMP7 CTSZ ARF1 CLTC CLTA AP4E1 DNM2 ARRB1 M6PR AP1G1 SH3GL2 AP1S2 AP1S1 AP1S3 HSPA8 CHMP2A AP4M1 AP1G2 AP1B1 DNASE2 CLVS2 VAMP8 AP4S1 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis RHD RHCE CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 GLYATL2 GLYATL1 ACSM1 GLYAT ACSM2B CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway FZD3 FZD2 FZD5 FZD4 FZD6 GNAO1 PPP3CA PPP3CB PRKG1 CTNNB1 PDE6B PDE6A GNG3 PDE6G TNRC6C GNG2 MOV10 GNG5 AGO3 GNG4 AGO4 GNG7 AGO1 AGO2 GNG8 TNRC6A TNRC6B PRKCA PLCB3 TCF7L1 PLCB1 PLCB2 NFATC1 CALM1 PRKG2 TCF7L2 MAP3K7 WNT11 TCF7 GNG10 LEF1 GNG12 GNG11 GNG13 GNB2 ITPR1 GNB1 ITPR2 GNB4 ITPR3 GNB3 GNB5 CAMK2A GNAT2 GNGT1 WNT5A GNGT2 NLK PPP3R1 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation SYK NRAS PIK3R1 FYN PLCG2 PTPN6 NFKBIB CD19 AHCYL1 PIK3AP1 BTRC RELA SKP1 TRPC1 CALM1 FBXW11 RASGRP3 NFKB1 NFATC3 UBA52 STIM1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 ORAI2 IGKV1-17 ORAI1 IGKV1-12 IGHV3-7 IGHV3-9 CUL1 IGHV3-30 PSMD12 PSMD11 UBB IGHV3-33 PSMD14 PSMD13 IGKV1D-39 UBC IGKV1D-33 PSMA7 IGKV2D-28 IGHM IGKV4-1 PSMB6 RPS27A PSMD8 IGHV7-81 CARD11 ITPR1 PSMB7 ITPR2 PSMB4 PSMD6 IGKV2D-30 IGHD PSMB5 PSMD7 ITPR3 IGHV4-59 PSMB2 IGHV1-69 PSMB3 PSMD2 BCL10 PSMD3 RASGRP1 PSMB1 PSMD1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 ADRM1 PPP3R1 IGLV2-14 IGLV1-44 PSMA5 IGKV3-15 SEM1 IGKV3-11 PSMA6 LYN PSMA3 PSMC5 PSMA4 IGKV2D-40 PSMC6 IGHV3-11 IGHV3-13 PSMC3 IGKV1D-16 PSMA1 DAPP1 IGLV7-43 PSMA2 IGKV1D-12 REL PSMC4 NFKBIA PPP3CA PSMC1 IGLV1-51 PPP3CB PSMC2 IGLV2-23 NFKBIE IGKV3-20 BLK IGHV4-34 IGHV1-2 SH3KBP1 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 CHUK IGLC2 PPIA IGKV3D-20 NCK1 IKBKB IGLV3-19 IGKV2-30 IGHV2-70 IKBKG IGHV2-5 IGLV3-1 IGHV3-48 MALT1 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 IGLC6 NFATC2 NFATC1 CD79B CD79A BTK PIK3CD SOS1 MAP3K7 BLNK CD22 FKBP1A HRAS PRKCB VAV1 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM FGFR2 POLR2A POLR2B POLR2C POLR2D POLR2G NCBP1 POLR2I NCBP2 POLR2J FGF1 POLR2E POLR2F POLR2H GTF2F1 POLR2K GTF2F2 POLR2L FGF2 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2R1B PPP2R1A PRKACG PRKACA PRKACB PPP2R5D PFKFB2 PPP2CA PFKFB1 PPP2CB PFKFB4 PFKFB3 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 CYP2U1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity SNW1 USP9X MAPK1 NCOR2 MAPK3 PARP1 SKIL UBA52 NCOR1 TRIM33 TGIF1 TGIF2 ATP1B4 SKI SMAD2 UBB NEDD4L SMAD4 SMAD3 HDAC1 RNF111 SMURF2 UBC SMAD7 RPS27A UBE2D3 WWTR1 UBE2D1 PPM1A MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels KCNK13 KCNK16 KCNK17 KCNK18 KCNK2 KCNK4 KCNK9 KCNK6 KCNK3 KCNK7 KCNK1 KCNK10 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation JAK1 JAK2 IL6 IL6R TYK2 MAP2K2 MAPK1 PTPN11 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions PARD6G PATJ PALS1 CLDN2 CLDN6 CLDN4 CLDN3 CRB3 CLDN9 CLDN8 CLDN7 CLDN5 CLDN22 CLDN20 CLDN23 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 PRKCI CLDN1 PARD6B PARD6A F11R PARD3 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGFR NGF RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases PIK3C3 NCF1 PRKCD CYBB PRKCA CYBA NCF2 RAC1 NCF4 PRKCZ MAPK1 PIN1 NOXA1 S100A9 MAPK3 NOXO1 RAC2 S100A8 NOX3 PIK3R4 MAPK14 NOX1 MAPK11 PRKCB VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability VAV2 CALM1 CAV1 THEM4 RAC1 CTNNB1 PAK2 RICTOR CDH5 JUP PRR5 PAK1 PDPK1 CTNNA1 AKT2 AKT3 PAK3 MLST8 AKT1 MAPKAP1 NOS3 CTNND1 TRIB3 MTOR VAV3 HSP90AA1 VAV1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein ST3GAL1 ST8SIA3 ST3GAL2 ST3GAL3 HK1 NUS1 GLB1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 DPM1 DPM2 DPM3 SLC35C1 ST6GALNAC1 CMAS NPL NANP NEU4 ST8SIA4 NANS ST3GAL6 ST6GAL2 ST8SIA1 DPAGT1 GNE MPI ST8SIA5 MVD ALG5 NUDT14 DOLK NAGK CTSA GFPT2 AMDHD2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP SRD5A3 ST3GAL5 ALG14 ALG13 ALG12 ALG11 GMPPB FPGT GMPPA GFUS ALG8 ALG9 ALG10 ALG6 ALG10B ALG2 FUOM ALG3 DHRSX ALG1 GMDS PMM1 FCSK DOLPP1 ST6GAL1 RFT1 SLC35A1 NEU2 NEU3 ST6GALNAC5 ST6GALNAC6 NEU1 DHDDS SLC17A5 ST8SIA6 MPDU1 ST3GAL4 PMM2 ST8SIA2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism PPM1K ACAT1 CRAT BCAT2 ACAD8 HSD17B10 ALDH6A1 BCKDK DLD GLYAT DBT ACADSB MCCC2 BCKDHA MCCC1 SLC25A44 HIBADH BCKDHB IVD AUH BCAT1 HIBCH ECHS1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants EP300 PSEN2 APH1A HDAC4 APH1B HEYL MYC TBL1XR1 HDAC8 ADAM10 CREBBP PSENEN ADAM17 HDAC11 MAML2 PSEN1 CDK8 MAML1 HDAC5 NCSTN HDAC9 HDAC6 DLL4 MAML3 HDAC7 NEURL1 MIB1 SKP1 HDAC10 HEY1 JAG2 HEY2 SNW1 MAMLD1 NEURL1B RBX1 NCOR2 KAT2B KAT2A UBA52 MIB2 NCOR1 CUL1 HDAC2 TBL1X HDAC3 UBB NOTCH1 HDAC1 UBC RBPJ DLL1 RPS27A HES5 JAG1 HES1 CCNC FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism GLYCTK ALDOB ALDH1A1 KHK TKFC ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase EP300 HSPA1L PTGES3 HSPA2 FKBP4 HSP90AB1 HSPA1B HSBP1 HSF1 HSPA8 DNAJB1 CREBBP HSPA1A HSP90AA1 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations DAG1 POMT2 B3GALNT2 POMT1 POMGNT2 POMK DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) EP300 MEN1 HDAC4 TBL1XR1 KMT2A HDAC8 CREBBP HDAC11 BMI1 ETS1 YY1 IL4R MAML2 KLF13 MAML1 RING1 SMARCA4 IL13 MAF IRF4 HDAC5 SATB1 HDAC9 RNF2 HDAC6 MAML3 HDAC7 NOTCH2 STAT6 STAT5A DPY30 ASH2L CBX8 CHD4 STAT5B CHD3 PHC2 CBX6 PHC1 JUN POU2F1 HDAC10 CBX4 CBX2 NFATC2 SNW1 POU2F2 MAMLD1 PHC3 BATF IL4 IL5 WDR5 FOS NCOR2 KAT2B KAT2A NCOR1 GATA3 HDAC2 TBL1X HDAC3 NOTCH1 MBD3 HDAC1 RBPJ MTA1 RBBP4 RBBP5 GATAD2B GATAD2A RBBP7 MTA2 MTA3 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPL18 MRPS33 MT-CO2 MRPL19 MRPS34 MT-CO3 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MT-ATP6 MRPL22 MRPL30 MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 OXA1L MT-ATP8 KGD4 MT-CYB MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MT-ND4L MRPS23 MTRF1 MRPL49 MRPS18B GFM2 MT-CO1 MRPS18A MRRF MRPS21 MTRF1L MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia MYB MCIDAS E2F5 CCDC78 GRHL1 RFX2 RFX3 CCNO GRHL3 GRHL2 TNRC6C DEUP1 MOV10 AGO3 AGO4 AGO1 AGO2 GMNC TNRC6A TNRC6B FOXJ1 NOTCH1 DLL1 TFDP1 E2F4 TP73 GMNN DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes SMAD2 SMAD4 CDKN1B PCBP4 CCNG2 SMAD3 CAV1 RBL2 FOXG1 GADD45A CDKN1A FOXO4 FOXO3 FOXO1 MSTN KLF4 BTG1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks KAT5 ATM MRE11 RAD50 KPNA2 NBN SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE LPIN1 LPIN2 SELENOI LPIN3 CEPT1 PCYT2 CHKB CHKA ETNPPL PISD PHOSPHO1 ETNK2 ETNK1 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic RAB30 GOSR2 RAB39A RAB36 NAPA STX5 ALPP YKT6 SNAP29 NSF RAB33B CUX1 TRIP11 ARF1 RIC1 STX16 RGP1 GOSR1 GOLIM4 CYTH3 CYTH2 RAB41 GOLGA5 CYTH4 VPS45 STX6 NAPB VTI1A MAN1A2 CYTH1 MAN1C1 COG8 MAN1A1 COG7 MAN2A2 COG6 COG1 NAPG COG5 COG4 COG3 MAN2A1 COG2 BET1L SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs XIAP CASP3 DIABLO APAF1 CASP9 CYCS CASP7 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion STAG1 CDCA5 STAG2 PDS5B ESCO1 PDS5A ESCO2 SMC1A WAPL SMC3 RAD21 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling NRAS PTPN11 FRS2 FGF1 FGF7 FRS3 FGF4 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm NXT1 NUP37 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 NUP107 SRRM1 THOC6 NUP188 DDX39A DDX39B SARNP ZC3H11A SRSF2 WDR33 SRSF3 SRSF4 NUP210 SRSF5 SRSF6 SLU7 SRSF7 NUP93 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 NUP205 SRSF1 POM121 U2AF1 NUP214 U2AF1L4 NXF1 U2AF2 AAAS DHX38 SRSF11 CHTOP NUP160 ALYREF POM121C UPF3B NUP85 MAGOHB TPR NXF2B NUP88 RNPS1 FIP1L1 SYMPK NUP155 NUP153 NUP62 NDC1 SLBP SEC13 NCBP1 NUP133 NCBP2 NUP50 EIF4E NUP54 CPSF4 CPSF1 CPSF3 CPSF2 NUP42 NUP43 RAE1 RANBP2 NUP35 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency EIF2S1 DDIT3 ASNS ATF5 CEBPG ATF3 PPP1R15A EIF2AK1 TRIB3 ATF4 CEBPB GRB10 EIF2S3 EIF2S2 CHAC1 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 BANF1 NUP50 KPNA1 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 HMGA1 NUP153 PSIP1 NUP35 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation CALM1 FGF14 SCN8A FGF13 FGF12 FGF11 SCN11A SCN10A CACNG6 SCN5A SCN4A SCN4B RANGRF SCN7A SCN1B SCN1A CACNG7 CACNB2 CACNA1C SCN3B CAMK2B SCN3A SCN2A CAMK2D CACNG8 SCN2B CAMK2A CACNA2D2 CACNB1 CACNG4 CAMK2G SCN9A NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling NTRK2 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia F8 F9 F10 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape H2AC14 ERCC3 H2BC12L RRN3 H2AC8 ERCC2 H2AC6 H2AC7 H4C9 CBX3 CDK7 H2AC20 MNAT1 H2AX PHF6 H2BC26 H2BC21 H3-3B H3C8 UBTF TBP H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 H2BC9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 GTF2H1 GTF2H2 GTF2H3 TAF1A GTF2H4 POLR2E GTF2H5 POLR2F POLR2H CCNH H2AC19 POLR2K POLR2L H2AB1 H2AZ2 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDKN2A CDK4 CDK6 IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex PELI2 IKBKB IKBKG CHUK UBE2N IRAK1 PELI1 TRAF6 PELI3 UBE2V1 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers H2AC14 H2BC12L TCF4 SUPT16H TCF3 CREBBP NQO1 MYOG H4C9 MYOD1 CTR9 RTF1 H2AC20 PAF1 H2AX PWWP2B DHX15 ZMYND8 CHD5 IKZF1 MBD3L2 IKZF2 PHF6 IKZF3 MBD3L1 ADNP2 PWWP2A ZNF687 H3-3B TCF19 ADNP ZNF592 ZNF827 H3C8 CBX1 NR2F2 TCF12 CDK2AP2 DDX46 CDK2AP1 ZNF532 DDX42 RBM17 H2AJ SMNDC1 U2SURP SNRPD2 DKK2 SNRPD1 SNRPD3 SNRPA1 CHD8 H3C15 CHD7 CHD6 SF3B1 CTCF NKD2 MBD3 FAM124B IGF2 SF3B4 H2BC9 SF3B5 H2BC8 SF3B2 H2BC5 SF3B3 SF3B6 H2BC3 MBD2 SF3A3 H2BC1 SF3A1 SF3A2 GATAD2B GATAD2A SSRP1 H2AB1 CHERP EP300 H2AC8 H2AC6 PUF60 H2AC7 UBE2I SNRPB2 CTNNB1 FBP1 G6PC1 SUMO1 CHD2 PHF5A SNRPN CBX3 MAFK NFE2L2 CHD9 SKIC8 CHD4 CHD3 H2BC26 H2BC21 WDR5 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CDC73 AXIN2 HDAC2 HDAC1 LEO1 SNRPG MTA1 RBBP4 SNRPE SNRPF SNRPB PCK1 RBBP7 NR2C2 MTA2 MTA3 H2AC19 H2AZ2 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma HPR HPX IGHA1 IGHA2 AMBP JCHAIN APOL1 HBA2 APOA1 IGHV3-23 HP IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 ALB IGHV3-13 CD163 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 LRP1 HBB HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLBD1 PLA2G4A GPCPD1 PLA2G15 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling CUL1 NOTCH1 SKP1 RBX1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF4A2 EIF2B2 EIF2B1 EIF4A1 EIF2S2 RPL10 EIF2S1 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 EIF4E EIF4B RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 EIF5 RPS26 RPS25 EIF5B RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A PABPC1 EIF1AX EIF4EBP1 RPL22L1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF4G1 RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification PSMA5 ERLIN2 CD274 CUL3 SEM1 PSMA6 PSMA3 DERL2 PSMC5 PSMA4 RNF5 OST4 COPS5 PSMC6 OS9 PSMC3 OSTC PSMA1 STT3A PSMA2 PSMC4 PSMC1 RNF185 PSMC2 STT3B B3GNT3 PRKAB1 DDOST MAGT1 DAD1 CCND1 JAK1 PRKAG2 PRKAA1 CSNK2A1 GSK3B NEK2 BTRC CSNK2A2 SEL1L DERL3 PRKAG1 YWHAG DERL1 SPOP SKP1 CSNK2B PRKAG3 PRKAA2 PDCD1LG2 RBX1 ERLEC1 UBA52 MIB2 TUSC3 PDCD1 CUL1 PSMD12 PSMD11 UBB CDK4 PSMD14 PSMD13 UBC TMEM258 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PRKAB2 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 VCP RPN1 PSMB1 PSMD1 ADRM1 ERLIN1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration PLXNB1 MET RRAS RND1 ARHGAP35 RAC1 SEMA4D RHOA ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K PIK3CA GAB1 PIK3R1 NTRK2 BDNF INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins NRCAM SCN8A SPTA1 SCN11A SCN10A L1CAM SCN5A SCN4A SCN4B SPTB SCN7A SPTBN2 NFASC SCN1B SCN1A SPTBN1 ANK2 ANK3 ANK1 KCNQ2 KCNQ3 SPTBN4 SPTBN5 SCN3B SCN3A SCN2A SPTAN1 SCN2B SCN9A RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle WDR6 PIK3R2 HGS DST PIK3R1 SRGAP2 TXNL1 USP9X PEAK1 RHOU WWP2 IQGAP1 ARHGEF7 STAM2 VANGL1 ARHGEF6 PAK2 DEPDC1B MYO6 PTK2B DLG5 PAK1 CDC42 EPHA2 NCK2 PAK3 NCK1 PAK4 SPTBN1 GIT2 STAM ITSN2 CLTC ARHGAP31 ARHGAP30 SRC PARD6A SPTAN1 GIT1 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis NOS1 SLN ATP1B3 ATP1B2 ATP1B1 AHCYL1 KCNJ11 DMPK ABCC9 PRKACA SLC8A3 ATP2B4 ATP2A3 ATP2A2 ATP2B3 FXYD4 ATP2A1 ATP2B2 FXYD3 TRPC1 ATP2B1 SRI FXYD2 CALM1 SLC8A1 FXYD1 SLC8A2 FXYD7 FXYD6 RYR1 RYR2 RYR3 CLIC2 TRDN ASPH TNNI3 STIM1 ATP1A4 ATP1A3 ATP1A2 ORAI2 ORAI1 ATP1A1 PLN ITPR1 ITPR2 FKBP1B CAMK2B ITPR3 CAMK2D CAMK2A CAMK2G MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling UBE2K MAVS ATG12 RNF125 ATG5 TNFAIP3 NLRX1 OTUD5 PIN1 UBA52 UBE2D2 UBA7 TBK1 CYLD IRF3 UBE2L6 ISG15 TRAF3 TRIM4 IFIH1 HERC5 IKBKE NLRC5 TRIM25 UBB RIGI UBC ITCH PCBP2 RPS27A UBE2D3 TAX1BP1 RNF216 UBE2D1 RNF135 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation F2 SERPINC1 SERPIND1 ITGA2B PROC SERPINE2 F13B ITGB3 F13A1 SERPINA5 FGB FGA FGG PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism PCCA MMAA PCCB MCEE MMUT CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis CHSY3 NCAN CHPF2 BGN CHST11 VCAN CHST12 CHST15 CHST13 CHST3 CSPG5 DCN UST CSGALNACT1 CHST7 CSGALNACT2 CHPF CHSY1 BCAN DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation HGF MET PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 CCNB1 CDC20 PLK1 FBXO5 CDK1 FZR1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery ELOA NELFB ELOB NELFCD NELFA ELOC NELFE CCNK CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F ELOA2 POLR2H SUPT5H CDK9 SSRP1 POLR2K POLR2L TCEA1 ELL ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CCNE1 CDKN1B CDK4 CDK2 CCND3 CCND2 TFDP1 TFDP2 CDKN1C RB1 E2F2 CDKN1A E2F1 E2F3 CDK6 CCNE2 CCND1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPX2 ALOX15 GPX1 GPX4 PTGS2 ALOX15B GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade VAV2 RHOB PIK3R2 LYN SYK PIK3CB PIK3R1 RAC1 FYN PRKCZ LCP2 PDPN RHOA MPIG6B PLCG2 GP6 PIK3CA PTPN6 PDPK1 CDC42 PIK3CG LCK FCER1G PTPN11 RAC2 PIK3R3 PIK3R6 VAV3 PIK3R5 RHOG CLEC1B VAV1 LAT CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) GRM3 TAS2R50 GRM2 GRM7 GRM6 GRM1 GRM8 TAS2R19 GRM5 TAS2R42 TAS2R45 TAS2R40 TAS2R41 TAS2R43 GABBR2 TAS2R60 TAS2R46 GABBR1 TAS2R30 TAS1R2 TAS1R1 TAS2R31 TAS1R3 TAS2R38 TAS2R39 TAS2R20 TAS2R7 TAS2R8 CASR GRM4 TAS2R1 TAS2R10 TAS2R3 TAS2R13 TAS2R5 TAS2R4 TAS2R14 TAS2R16 TAS2R9 GPRC6A GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation GJB2 GJB1 CLTB TJP1 GJC1 GJC2 GJA3 MYO6 GJA10 GJA5 DAB2 GJA1 CLTCL1 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CLTC CLTA DNM1 DNM2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex H2AC14 CDT1 CDC6 H2BC12L KPNA1 H4C9 H2AC20 H2AX ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 H3-3B ANAPC7 UBE2C H3C8 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 H2AJ UBA52 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 H2AB1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 KPNA6 KPNB1 H2BC26 MCM7 MCM8 H2BC21 MCM3 MCM4 MCM5 MCM6 MCM2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 GMNN H2AC19 ORC5 ORC4 ORC6 ORC1 ORC3 H2AZ2 ORC2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription EP300 MEN1 E2F5 MYC CCNK CCNT2 MAPK1 CCNT1 MAPK3 UBA52 SP1 TGIF1 TGIF2 CDKN2B SERPINE1 SMAD2 UBB FURIN JUNB SMAD4 SMAD3 HDAC1 RNF111 UBC CDK8 SMAD7 RBL1 RPS27A TFDP1 TFDP2 YBX1 COL1A2 E2F4 WWTR1 CDK9 CCNC MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation JAK1 MAPK3 JAK2 IL6 IL6R MAP2K1 CDK1 TYK2 PTPN11 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NELFB POLR2A SUPT4H1 POLR2B NELFCD NELFA POLR2C POLR2D NELFE POLR2G NCBP1 POLR2I NCBP2 POLR2J POLR2E POLR2F SUPT5H POLR2H GTF2F1 POLR2K GTF2F2 POLR2L CTDP1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A CDK4 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events NRAS RALA MAPK12 RALGDS RALB MAPKAPK2 MAPK13 MAPK14 MAPK11 MAPKAPK3 HRAS PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere ACD TINF2 PCNA TERF1 TERF2 WRN POT1 TERF2IP BLM LIG1 RPA1 RPA2 POLD3 POLD1 FEN1 POLD4 POLD2 DNA2 RPA3 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency TCN2 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication MGME1 RNASEH1 SSBP1 EXOG POLG POLRMT POLG2 TOP3A TWNK VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation UBB NR1H3 MYLIP UBC CLTC NR1H2 CLTA AP2A1 PCSK9 AP2B1 RPS27A AP2A2 AP2S1 UBA52 VLDLR LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis VAV2 CD3G FCGR3A SYK FGR HCK FYN NCKAP1L WAS CDC42 ARPC1B ARPC1A MYO9B ACTG1 ABI2 WASL ABI1 IGHV3-23 NCKIPSD IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 BRK1 V1-7 V5-1 ABL1 V1-5 V1-3 IGKV3D-20 NCK1 V5-6 ACTR3 IGLV3-19 IGKV2-30 ACTR2 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 MYH2 V4-6 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 WASF1 WASF2 WASF3 BAIAP2 RAC1 MAPK1 MAPK3 ELMO1 BTK ELMO2 DOCK1 CRK PTK2 CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 YES1 VAV3 IGHG3 IGHG4 IGHG1 ACTB IGHG2 VAV1 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP1A1 ALOX15 ALOX12 CYP2C9 CYP2C8 CYP2D6 EPHX2 ALOX5 CYP1A2 CYP2E1 CYP3A4 PTGS2 HPGD LTA4H GSTM4 LTC4S ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants ALK CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA EP300 RIPK3 NFKB2 NFKBIA CTNNB1 AIM2 MYD88 NFKBIB NKIRAS1 CHUK NKIRAS2 IRF3 TREX1 NLRC3 IFI16 NLRP4 CREBBP IRF7 IKBKB IKBKG CRCP POLR3GL POLR3A XRCC6 POLR3B POLR3C POLR3D XRCC5 POLR3E POLR3F PRKDC POLR3G POLR3H STAT6 POLR3K RELA TLR3 ZBP1 DTX4 NFKB1 TRIM21 LRRFIP1 TRIM56 TICAM1 STING1 RIPK1 UBA52 POLR1C TBK1 POLR1D CGAS UBB DHX9 DHX36 MRE11 UBC RPS27A POLR2E POLR2F POLR2H POLR2K POLR2L TRIM32 DDX41 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNG3 GNB4 GRIK3 GNB3 GNG2 PLCB3 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 PLCB1 PLCB2 GNGT2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins BCL2 PMAIP1 BMF BID BBC3 DYNLL1 MAPK8 YWHAQ TP63 PPP3CC YWHAH PPP1R13B YWHAB AKT2 AKT3 AKT1 TP53 TP53BP2 YWHAZ YWHAE DYNLL2 TFDP1 TFDP2 TP73 E2F1 YWHAG BCL2L11 PPP3R1 SFN BAD NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 DOCK3 NTRK2 RAC1 BDNF SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 G6PC3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDKN2A CDK4 CDK6 TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation AIMP1 RPL24 AIMP2 RPL27 RPL26 RPL29 EPRS1 RPL28 SSR1 RPL41 RPL3L MT-ATP6 CUL2 MALSU1 MT-ND6 EEF1E1 MIEF1 MT-ND4 MTFMT MT-ND5 MTIF2 MTIF3 MT-ND2 MTRFR MT-ND3 MTRES1 MT-ND1 SERP1 UBE2D1 EIF2B5 EIF2B4 EIF2B3 MT-ATP8 EIF2S3 SRPRA EIF2B2 SRPRB EIF2B1 RPL10 NDUFAB1 EIF2S2 RPL12 EIF2S1 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPS15 RPS14 RPS17 UBA52 RPS16 UBE2D2 RPS19 RCHY1 RPS18 RPS11 RPS10 PSMD12 RPS13 PSMD11 UBB RPS12 PSMD14 PSMD13 UBC RPLP1 PSMA7 RPLP0 PSMB6 RPS27A PSMD8 UBE2D3 TRMT112 PSMB7 PSMB4 PSMD6 RPS4Y2 RPLP2 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RPS4Y1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 SEC61A2 PSMC3 PSMA1 SEC61A1 RPS26 SEC61G PSMA2 RPS25 SEC61B PSMC4 RPS28 KARS1 PSMC1 RPS27 PSMC2 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 SARS1 RPL37A GSPT2 GSPT1 RPL36A ETF1 RPL35A PABPC1 EIF1AX RPL22L1 EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L RPS15A EIF4G1 RPS3 ABCE1 MRPS17 RPS2 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 RBX1 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 FAU MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 RARS2 AARS2 MRPL42 PARS2 MRPL3 RPS9 MRPL2 MARS2 MRPL1 DARS2 MRPL40 YARS2 RPS7 HARS2 RPS8 MRPL9 FARS2 CHCHD1 MRPS28 RPS5 WARS2 LARS2 TSFM MRPS26 SARS2 MRPS27 NARS2 RPS6 TARS2 MRPS24 MRPS25 RPSA IARS2 MRPS22 VARS2 MRPS23 TUFM CARS2 EARS2 MRPL49 MRPS18B RPL39L MT-CO1 MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 HEMK2 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 VCP MRPL53 QARS1 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 LARS1 MRPL18 MRPS33 MT-CO2 MRPL19 MRPS34 MT-CO3 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 IARS1 MRPL54 MRPL55 MRPL11 RPL10L MRPL20 RPL10A GADD45GIP1 RPS4X PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 RARS1 RPS3A MRPL21 MRPL22 MRPL30 RPL23A ZNF598 ASCC2 ASCC3 OXA1L APEH EIF4A2 EIF4A1 ELOB SRP19 TRAM1 SRP54 ELOC SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RPL27A RPL13A EIF4E EIF4B MARS1 RPL18A RPL36AL KGD4 EIF5 EIF5B PELO AARS1 HARS1 YARS1 WARS1 GARS1 NARS1 CARS1 FARSA TARS1 VARS1 FARSB MT-CYB EEF1B2 EEF1G EEF1A1 EEF1D EEF1A2 SEC11A EEF1A1P5 SEC11C EEF2 DARS1 SPCS3 SPCS2 SPCS1 RPL26L1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL9P9 RPL8 RPL6 RPL7 RPL36 MT-ND4L PPA2 RPL35 PPA1 MTRF1 GFM2 MRRF RPL38 MTRF1L RPL37 RPL39 ANKZF1 KLHDC10 RPL21 NPLOC4 TCF25 RPL23 UFD1 RPL22 NEMF SRP14 LTN1 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes EP300 MAFK NFE2L2 CCL2 CREBBP PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants FLT3 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling DUSP16 DUSP10 NRAS JAK2 DUSP6 NF1 DUSP7 ARRB2 AGK QKI ITGB3 PPP1CC TRAK1 MAP3K11 APBB1IP KSR1 KDM7A KSR2 YWHAB FGB FGA RAF1 FGG RAP1B SHOC2 KRAS ESRP1 FAM114A2 MARK3 PPP1CB SRC ARRB1 ZC3HAV1 CSK AP3B1 TLN1 FN1 CALM1 FXR1 DUSP8 DUSP9 VCL PHB1 MAP2K1 MAP2K2 IQGAP1 LMNA RAP1A MAPK1 BRAF AKAP9 MAPK3 KIAA1549 ATG7 FAM131B TRIM24 BRAP MRAS VWF ITGA2B CLCN6 ARAF AGTRAP CNKSR2 CNKSR1 MPRIP CAMK2B AGGF1 PEBP1 SND1 CAMK2D CAMK2A SPRED3 SPRED2 SPRED1 PAPSS1 HRAS CAMK2G TENT4A BCL2L11 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses G3BP2 NLRP3 IFNA21 MAVS UBE2N TAB3 TAB2 TAB1 NUP107 NUP188 HSP90AB1 PTPN6 MBL2 NUP210 IRF3 NUP93 TRAF3 CREBBP TRAF6 IRF7 PIK3C3 NUP205 POM121 BECN1 SEC23A AAAS NOD1 NOD2 NUP160 POM121C NUP85 SEC24B TPR SEC24A NUP88 TLR1 CNBP PTPN11 NUP155 NUP153 TLR2 SEC24D SEC24C HSP90AA1 NUP62 NDC1 SEC13 NUP133 NUP50 NUP54 TBK1 B2M NUP42 HLA-H HLA-B HLA-C NUP43 HLA-A ATG14 HLA-F RAE1 HLA-G RANBP2 HLA-E SAR1B PIK3R4 LARP1 NUP35 NUP37 IFNA5 IFNA4 IFNA7 CHUK IFNA6 IFNA1 IFNA2 IFNA8 ISG15 TRIM4 IFIH1 IKBKE IKBKB JAK1 TOMM70 TRIM25 NUP214 IKBKG RIPK2 RIGI SFTPD TYK2 IL17RC IL17RA SIKE1 TLR8 TLR7 RNF135 STAT1 IFNB1 STAT2 NLRP12 STING1 IL17F IL17A KPNA2 MAP3K7 IFNA14 IFNA16 IFNA17 UBE2V1 MASP1 IFNA10 IFNAR1 TKFC IRAK1 IRAK2 G3BP1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DHRSX MVD DOLK DOLPP1 DHDDS SRD5A3 NUS1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGFR3 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF2 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes NFE2L2 IDH1 ME1 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin SMAD2 SMAD4 SMAD3 TGFBR3 INHBB ACVR1B INHBA FSTL3 DRAP1 ACVR1C ACVR2B MAPK1 ACVR2A INHA MAPK3 FST FOXH1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion CXCR4 CCR5 CD4 PPIA YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression TEAD1 TEAD2 TEAD3 TEAD4 TBX5 NPPA NKX2-5 KAT2B WWTR1 GATA4 HIPK1 YAP1 HIPK2 CCN2 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling IL2RB JAK1 SHC1 IL2 SYK PTK2B STAT5A STAT5B IL2RG LCK IL2RA JAK3 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis ADSS2 PPAT ATIC ADSL GART PFAS PAICS IMPDH1 ADSS1 IMPDH2 GMPS DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHAG RHCG RHBG SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells STAT3 PBX1 SMAD2 SALL1 SMAD4 SALL4 FOXD3 EPHA1 PRDM14 DPPA4 CRIPTO HIF3A LIN28A ZIC3 ZSCAN10 NR5A1 NANOG EPAS1 KLF4 POU5F1 SOX2 FGF2 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants KRAS NRAS HRAS DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization NECTIN4 NECTIN3 NECTIN1 CADM3 CADM1 NECTIN2 PVR ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans HAPLN1 TGFB2 NCAN ITGAX TGFB3 BGN ASPN VCAN ITGA7 LAMA2 LAMA4 LRP4 LAMB2 ITGB3 ITGA9 ITGB5 ITGAV ITGB6 HSPG2 TGFB1 BCAN SERPINE1 LUM COL9A1 COL9A3 COL9A2 LAMC1 DCN AGRN ITGB1 LAMA1 FMOD SPARC DMP1 MUSK NCAM1 LAMA5 PTPRS LAMA3 MATN1 MATN4 MATN3 ACAN ITGA2 TNXB ITGA2B LAMB1 DSPP TNC COMP DAG1 IBSP TNN TNR VTN ITGA8 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A6 SLC25A4 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis LRP2 CD3G IL7R EGF EGFR NEDD8 LDLRAP1 EPGN SCARB2 ARRB1 AGFG1 M6PR KIAA0319 VAMP3 TOR1A TOR1B GPS1 SYT9 SYT8 SNAP91 AAK1 STON1 STON2 SH3GL3 SLC2A8 SLC18A3 VAMP8 SH3GL1 SGIP1 EPN2 VAMP4 FCHO1 HGS FCHO2 UBQLN1 TGOLN2 REPS2 UBQLN2 REPS1 NECAP2 SYT11 STAM2 UBA52 IGF2R NECAP1 VAMP7 CD4 UBB UBC AGTR1 CD3D RPS27A GRK3 COPS7B COPS7A WNT5A SYT2 DVL2 COPS3 COPS6 FZD4 COPS5 VAMP2 CLTB COPS8 ARRB2 TACR1 COPS4 COPS2 SH3KBP1 DAB2 CLTCL1 AVP TF AREG AVPR2 CLTC EPS15 CLTA AP2A1 AP2B1 AP2A2 AP2S1 SH3GL2 GRK2 EREG BTC CFTR HBEGF PICALM CHRM2 CBL ADRB2 APOB STAM ITSN2 TGFA TFRC EPS15L1 EPN1 ITSN1 SYT1 LDLR MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression ENSA PPP2R1B PPP2R1A CCNB1 MASTL PPP2R2D CDK1 PPP2CA ARPP19 PPP2CB MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation FASTKD2 FASTKD5 TBRG4 SUPV3L1 GRSF1 PNPT1 SLIRP REXO2 LRPPRC PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors PTGER1 PTGER3 TBXA2R PTGDR2 PTGDR PTGER4 PTGFR PTGIR PTGER2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function LRAT RBP1 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis LHB CGA HSD3B2 CYP11B2 CYP21A2 HSD3B1 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria CALM1 UBB UBC GBP2 GBP1 RPS27A UPK1A GBP4 CASP4 CALM3 CALM2 GBP6 UBA52 UBE2D2 HBA2 HBB EPCAM MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development LARS1 AIMP1 MC4R DPF1 AIMP2 HINT1 TFEB EDNRB RPS6KA1 DPF2 TNFSF11 FOXD3 DPF3 EPRS1 EDN1 EDN3 TFE3 SMARCC1 MITF SMARCC2 SOX10 POU3F2 STT3B MC3R IARS1 TFEC ALX3 TBX3 MC1R ID1 DCT TNRC6C MC5R MOV10 AGO3 LIG1 AGO4 YWHAH AGO1 RARS1 AGO2 PPARGC1A SNAI2 TNRC6A TNRC6B CREBBP CCND1 SERPINE1 SS18L1 EEF1E1 SMARCA2 CEACAM1 SMARCA4 YWHAE TFAP2A TRPM1 ZEB1 YWHAG ASAH1 TCF7L2 ATP6V1H CDKN2A SS18 ACTL6A DICER1 GXYLT2 SIRT1 BCL2A1 SYTL2 PMEL EDIL3 MLANA TBX2 MLPH USF1 AKT2 AKT3 MYRIP CCNB1 MARS1 ITGA2 LEF1 DIAPH1 PLK1 EP300 GMPR BCL2 POMC CDC25B UBE2I ATP6V1E1 KARS1 ATP6V1G1 ATP6V0E1 CTNNB1 CDH1 SUMO1 TYR GPR143 YWHAB ATP6V0D1 ATP6V1A XPO1 TYRP1 MET YWHAZ MARK3 IRF4 MYO5A ATP6V1C1 CDH2 GSK3B CDKN1A DARS1 TCF7L1 WNT3A MAPK14 BRCA1 PAX3 SOX2 BCL7A SIN3A ZIC1 BCL7C BCL7B RAB27A MCM5 SOX9 MCM2 ATP6V0B ARID1A ARID1B MAPK1 ATP6V1B2 MAPK3 ATP6V0C PXDN BIRC7 KIT PXN SMARCD1 SMARCD2 TCF7 SMARCD3 TERT CDK2 HDAC1 SMARCB1 CSF1 QARS1 SMARCE1 ACTB TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling CASP8 TNFSF10 CASP10 TNFRSF10D FADD CFLAR TNFRSF10B TNFRSF10A DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF7 EGF FGF4 FGF10 FGF2 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants KREMEN1 KREMEN2 DKK1 DKK2 DKK4 LRP5 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS CUL3 HMG20B SYK JAK2 PLCG2 JAK3 HSP90AB1 SIGMAR1 TLR9 HSP90AA1 ZBP1 TUBB CRBN FNTA FNTB FKBP4 RIPK1 IGHV3-23 TBK1 IGLV IGLV2-8 IGKV1-16 PDCD1 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 MBD3 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGHM IGKV4-1 BRD4 IGHV7-81 ARID4A ACE2 IGKV2D-30 IGHD GATAD2B IGHV4-59 GATAD2A IGHV1-69 IL6R IGLV2-11 IGLV1-40 IGLV1-47 ARID4B IGLV6-57 BRMS1 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 SAP30 IGKV1D-12 NR3C1 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 ATP1B3 SH3KBP1 IGHV1-46 IGHV4-39 ATP1B2 IGKV2-29 ATP1B1 IGKV2-28 IGLC3 IGLC1 IGLC2 IFNGR1 IFNGR2 IGKV3D-20 NCK1 SUDS3 JAK1 IGLV3-19 REST IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 NFE2L2 IGLV3-25 IGLV3-27 TYK2 IGKC AP2A1 IGKV1-39 IGLV3-21 AP2B1 IMPDH1 IGKV1-33 IMPDH2 AP2A2 IGHV3-53 ROCK2 S1PR1 IGLC7 AP2S1 IGKV5-2 IGKV1-5 IGLC6 CHD4 IL1R1 CHD3 ITGA4 TLR7 ROCK1 FXYD4 KEAP1 FXYD3 FXYD2 CD79B FXYD1 FXYD7 CD79A FXYD6 KDM1A PTGES3 RBX1 STAT2 BTK COMT ITGB1 ATP1A4 ATP1A3 SOS1 ATP1A2 ATP1A1 PHF21A HDAC2 FURIN BLNK HDAC1 MTA1 RBBP4 SAP30L RCOR1 SAP18 IFNAR1 RBBP7 MTA2 FKBP1A MTA3 CYSLTR1 VAV1 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 PAK5 NCK1 PAK4 ROBO1 RAC1 SLIT2 SOS2 PAK2 PAK1 SOS1 PAK6 NCK2 PAK3 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 UBE2I FBP1 G6PC1 SUMO1 H4C9 H2AC20 H2AX PWWP2B ZMYND8 CHD5 CHD4 IKZF1 CHD3 MBD3L2 IKZF2 PHF6 IKZF3 H2BC26 MBD3L1 PWWP2A ZNF687 H2BC21 H3-3B TCF19 ZNF592 H3C8 ZNF827 NR2F2 CDK2AP2 CDK2AP1 ZNF532 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 HDAC2 H3C15 MBD3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 MBD2 H2BC1 GATAD2B GATAD2A RBBP7 PCK1 NR2C2 MTA2 MTA3 H2AC19 H2AB1 H2AZ2 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants CDC37 ERBIN ERBB2 HSP90AA1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF4A2 EIF2B2 EIF2B1 EIF4A1 EIF2S2 RPL10 EIF2S1 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 EIF4E EIF4B RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 EIF5 RPS26 RPS25 EIF5B RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A PABPC1 EIF1AX EIF4EBP1 RPL22L1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF4G1 RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance ALDOB NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes MAFG EP300 PGD TALDO1 TKT G6PD NFE2L2 CREBBP TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors VEGFA YY1 ERBB2 EGFR TFAP2A TFAP2B TGFA ESR1 TFAP2C CGB8 CGA ATAD2 KIT BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 CSNK1D RPL17 RPL19 CSNK1E SNU13 RPL27A RPL13A RPS15 RPS14 EXOSC10 RPS17 UBA52 LTV1 RPS16 C1D RRP1 RPS19 FTSJ3 MPHOSPH6 EBNA1BP2 RPS18 ISG20L2 ERI1 LAS1L NOL12 RBM28 RPS11 RIOK2 XRN2 RIOK1 TEX10 RPS10 SENP3 RPS13 GNL3 NIP7 RPS12 NOL9 PES1 RIOK3 WDR18 WDR12 RPLP1 BYSL RPLP0 BOP1 RPS27A TSR1 RPS4Y2 RPLP2 NCL RPL18A RPL36AL RPS4Y1 MTREX RPS26 RPS25 RPS28 RPS27 RPS29 NOP58 RPL7A RPS20 RPS21 RPS24 DDX49 RPS23 DDX47 WDR3 FCF1 PWP2 WDR46 WDR43 RRP9 FBL RPL37A BUD23 UTP14A UTP14C NOP56 UTP15 WDR36 UTP11 IMP3 RPL36A DIS3 WDR75 IMP4 DDX52 UTP18 RPL35A UTP25 HEATR1 RPL22L1 NOC4L NOL6 RRP7A EXOSC7 EMG1 EXOSC6 PDCD11 EXOSC5 EXOSC4 BMS1 EXOSC9 DHX37 EXOSC8 RRP36 EXOSC3 UTP20 EXOSC2 EXOSC1 DCAF13 UTP6 NOP14 UTP4 RPS27L UTP3 PNO1 KRR1 RCL1 RPS15A TBL3 MPHOSPH10 NOL11 RPS3 RPS2 PELP1 RPP30 RPP38 RPP21 RPP25 RPL26L1 FAU RPL4 RPL5 RPP14 RPL30 RPL3 RPL32 RPP40 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 DDX21 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling DSCAM PITPNA RAC1 AGAP2 HJV DSCAML1 UNC5A UNC5B DCC UNC5C DOCK1 NTN4 WASL UNC5D NTN1 ABLIM1 CDC42 ABLIM2 SIAH2 ABLIM3 SIAH1 NCK1 EZR ROBO1 PTK2 PLCG1 SLIT2 SLIT1 TRIO PTPN11 PRKCQ MYO10 SRC NEO1 TRPC7 TRPC5 SLIT3 TRPC6 RGMB TRPC3 RGMA TRPC4 TRPC1 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport TTPA MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants FLT3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding CCT2 STAT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 AP3M1 TUBA3E GNA14 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 RGS11 TP53 TUBA1A CSNK2A1 CSNK2A2 CSNK2B GBA1 DCAF7 CCT6B TUBB6 TUBA4A TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 CCNE2 CCNE1 XRN2 GAPDHS FKBP9 HDAC3 GNG10 GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 PDCL GNB4 GNB3 FBXL3 GNB5 TUBB4B FBXL5 TUBB4A TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 ACTB KIF13A CCT3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes YWHAE CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells MPO LPO FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate ZEB2 SOX1 OTX2 POU3F1 WNT3A ZNF521 SOX2 FGF8 TBX6 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER CUL4A ERCC3 POLE4 ERCC2 POLE2 ERCC6 POLE3 AQR CUL4B PRPF19 LIG1 POLD1 RFC5 RFC3 RFC4 RFC2 CDK7 MNAT1 ERCC8 ZNF830 RBX1 PCNA ISY1 UBA52 RPA1 RPA2 RPA3 POLR2A UBB POLR2B POLK POLR2C POLR2D POLE UBC RFC1 POLR2G POLR2I RPS27A USP7 LIG3 POLR2J GTF2H1 GTF2H2 GTF2H3 XAB2 DDB1 GTF2H4 POLR2E GTF2H5 POLR2F POLR2H CCNH PPIE POLR2K POLD3 POLR2L POLD4 TCEA1 POLD2 XRCC1 UVSSA L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions VAV2 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ALCAM SCN11A SCN10A L1CAM LYPLA2 CNTNAP1 ITGB3 SPTB ITGA9 PAK1 NFASC ITGAV RPS6KA4 EPHB2 SCN1B SCN1A RANBP9 ANK2 EGFR SHTN1 KCNQ2 KCNQ3 SPTBN4 SPTBN5 SDCBP SCN3B SCN3A SCN2A CD24 SCN2B NRP2 SCN9A NRCAM SCN8A SPTA1 SCN5A GAP43 DCX SCN4A SCN4B MSN LAMA1 SCN7A RPS6KA6 CNTN6 CHL1 ITGA2 ITGA10 ANK1 ITGA2B DLG3 DLG4 NCAN NRP1 DLG1 DPYSL2 ITGA1 EZR CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 CSNK2A1 DNM3 AP2S1 SH3GL2 CSNK2A2 RDX HSPA8 LAMC1 CSNK2B ITGA5 CNTN1 RAC1 MAP2K1 MAP2K2 MAPK1 MAPK3 NUMB ITGB1 SPTBN2 NCAM1 SPTBN1 CNTN2 ANK3 LAMB1 KIF4B KIF4A SPTAN1 DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME VAV2 NME2 HPRT1 SLC16A1 NME1 SULT1A1 BCHE TPMT SULT1A4 SULT1A3 ACY1 GSTM1 CYP2C9 ADA CYP2C8 ADK CYP2D6 SERPINA6 CYP2E1 CYP3A4 ABCG2 XDH SULT1C4 SLC22A2 SLC22A1 UGT1A1 HSD11B1 GSTP1 HSD11B2 UGT1A5 UGT1A3 SULT1E1 ABCC3 UGT1A9 ABCB1 ABCC1 ABCC4 ABCC2 GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 ABCC5 UGT1A6 GLYAT NUDT15 SLC22A3 SLC22A8 AKR1C1 PON3 UGT2B10 UGT2B11 UGT2B15 PON1 UGT2B17 NAT1 PNP NAT2 UGT3A2 GMPS UGT3A1 GGT1 GSTT1 CYP2C19 ALB BSG NT5C2 GGT5 GGT7 GGT6 UGT1A4 ADH1A ACSM2A ACSM2B IMPDH1 GGT3P UGT1A10 UGT2A3 IMPDH2 UGT2A2 SLC28A2 UGT2A1 SLC29A1 SLC29A3 SLC29A2 SLC28A3 UGT2B4 ACSM5 ACSM4 MAPDA UGT2B7 SLCO1B1 SLCO1B3 RAC1 UGT2B28 GSTA2 GSTA1 SLCO1A2 CNDP2 ITPA CES2 CES1 SULT2A1 PCK1 VAV3 GUK1 VAV1 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores DYNC1LI1 DYNC1LI2 NUP37 CDCA8 ITGB3BP NDC80 SKA1 RPS27 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B BUB1 CLASP2 XPO1 SPDL1 DYNC1I1 CENPE NUF2 NUDC NUP160 DYNLL2 NUP85 BIRC5 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L NSL1 ZWILCH CENPA PPP2R5B PPP2R5A PPP2R5D CENPC PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E KNTC1 CENPT CENPU SEC13 SGO1 SGO2 NUP133 DYNLL1 CKAP5 CENPF KNL1 ZW10 CENPH RANGAP1 MAPRE1 PMF1 CENPI TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO DSN1 CENPP CENPQ CENPS BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 NUP43 KIF18A CLASP1 RANBP2 DYNC1H1 NDE1 PLK1 CLIP1 NDEL1 MAD1L1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 CCT6B TUBA3E TUBB6 TUBA4A TUBB3 TUBA3D TUBB1 TUBA3C CCT8 CCT7 CCT5 TUBA4B CCT4 CCT6A TUBA1A TUBB4B TUBB4A TUBA8 TUBA1C TUBA1B ACTB CCT3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression H2AC14 H2BC21 H3-3B H2BC12L H3C8 H2AC8 H2AC6 H2AC7 TBP H2BC17 SIRT1 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 H4C9 H3C15 H2BC9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 H2AC20 TAF1C H2BC1 TAF1A H2AX SUV39H1 H2AC19 H2BC26 H2AB1 RRP8 H2AZ2 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer SHC1 GAB1 CDC37 UBB EGF NRAS PIK3R1 AREG PLCG1 EGFR UBC TGFA RPS27A EREG BTC EPGN PIK3CA UBA52 HBEGF SOS1 HRAS CBL HSP90AA1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT3 LYN PIK3R2 NRAS PIK3R1 JAK2 FYN LCK STAT1 PIK3CA STAT5A YES1 STAT5B PIK3R3 SOS1 KIT HRAS CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic CDT1 CDC6 JAK2 KIF23 KIF2A KIF2C FOXM1 KIF2B CABLES1 CENPE WEE1 VRK1 LEMD2 CTDNEP1 CNEP1R1 LMNB1 PSMD12 PSMD11 PSMD14 PSMD13 FBXL18 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 LYN PSMA3 PSMC5 GOLGA2 PSMA4 PSMC6 CDC25A CDC25B PSMC3 PRIM2 PSMA1 PRIM1 PSMA2 PSMC4 POLA1 PSMC1 POLA2 PSMC2 MAX DNA2 XPO1 AKT1 TNPO1 NUP214 PRKCA SET TPX2 CDKN1A KPNB1 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 E2F5 MCM6 MCM2 E2F6 RBX1 PCNA MAPK1 RPA1 RPA2 RPA3 BUB1B CDC20 FBXO5 CCNA2 CCNA1 BUB3 MAD2L1 KMT5A CDC25C CCND3 CCND2 NUP107 NUP188 RCC1 BANF1 LIG1 NUP210 MYBL2 NUP93 CHMP4C DHFR CHMP4B CHMP4A NUP205 POM121 RFC5 RFC3 RFC4 AAAS RFC2 HJURP NUP160 POM121C RBL2 NUP85 MIS18BP1 RBL1 TPR BIRC5 NUP88 NUP155 AURKB E2F4 NUP153 CDC7 CHMP2B CHMP2A FEN1 NUP62 NDC1 SEC13 NUP133 CDC14A RANGAP1 NUP50 CHMP3 NUP54 CHMP6 CHMP7 CDKN2B VPS4A NUP42 NUP43 RAE1 RANBP2 TUBB8 SPAST IST1 TUBB8B CC2D1B NUP35 RAN RAB2A GORASP2 NUP37 BLZF1 SMC4 SMC2 NCAPG NCAPH UBE2I NCAPD2 DYRK1A CKS1B PPP2R3B SUMO1 PKMYT1 ARPP19 NCAPH2 NCAPG2 CDK6 NIPBL ENSA SIRT2 NCAPD3 TP53 MAU2 MASTL MCPH1 PPP2R2D CSNK2A1 CSNK2A2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C CSNK2B PPP2CA PPP2CB PPP2R1B PPP2R5E LEMD3 RAB1A RAB1B ANKLE2 PRKCB DYNC1LI1 DYNC1LI2 ESCO1 ESCO2 CDCA8 MYC SKA1 SKA2 CDKN2D CDKN2C PTTG1 CCND1 LPIN1 LPIN2 LPIN3 NUF2 EMD NUDC YWHAE CEP57 DYNLL2 CETN2 CEP164 CCP110 PPP1CB PPP2R2A INCENP ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 ANAPC15 BTRC PRKACA ANAPC16 CENPA UBE2D1 CEP290 ANAPC10 NINL CENPC YWHAG ANAPC11 RAB8A FZR1 SKP1 CDK5RAP2 CDC23 OFD1 CDC26 HSP90AA1 CDC27 BORA CDCA5 CEP135 ANAPC7 PPP1R12A PDS5B FBXW11 PDS5A UBE2C CDKN2A WAPL TUBB CENPT CEP131 UBE2E1 ESPL1 HAUS4 CENPU HAUS3 CSNK1D UBE2S HAUS6 CDC16 ANAPC4 HAUS5 ANAPC5 CSNK1E SMC3 ANAPC1 TUBG1 DYNLL1 ANAPC2 RAD21 CKAP5 CENPF TUBA4A HAUS2 HAUS1 STAG1 CENPH AKAP9 STAG2 CEP63 CENPI SMC1A MAPRE1 SFI1 UBA52 TAOK1 AJUBA OPTN CENPK PAFAH1B1 CENPL CENPM SDCCAG8 DYNC1I2 CPAP AKT2 DCTN2 AKT3 CENPN SSNA1 DCTN3 CENPO CUL1 CENPP AURKA CENPQ CCNB2 CENPS CCNB1 UBB HAUS8 PRKAR2B HAUS7 UBC POLE CEP70 RFC1 CEP72 CEP192 PCNT RPS27A CEP76 CLASP1 CEP78 PLK4 OBI1 FIRRM LCMT1 DYNC1H1 ODF2 PPME1 CEP152 CDK11A TICRR NDE1 CDK11B PLK1 TUBB4B CLIP1 TUBB4A NEDD1 ALMS1 MAD1L1 CDK1 POLD3 CEP41 CEP43 POLD4 POLD2 POLE4 POLE2 POLE3 NDC80 RPS27 POLD1 SPDL1 RRM2 NSL1 LIN54 LIN37 KNL1 ZW10 LIN9 LIN52 DSN1 RCC2 ZWINT AHCTF1 TK1 RB1 CCNH NDEL1 H2AC19 H2AC14 H2BC12L HSP90AB1 MIS12 PPP1CC DYNC1I1 H4C9 HMMR NEK9 H2AC20 NEK6 NEK7 B9D2 SPC24 SPC25 H2AX ERCC6L ZWILCH H3-3B KNTC1 LBR H3C8 SGO1 SGO2 GTSE1 FKBPL TUBB6 TUBB3 TUBB1 PMF1 H2AJ E2F2 TUBA4B CCNE2 CCNE1 H3C15 NUMA1 TUBG2 MZT2B MZT2A NME7 TUBGCP2 H2BC9 MZT1 H2BC8 TUBGCP5 H2BC5 TUBGCP6 TUBGCP3 H2BC3 TUBGCP4 H2BC1 TUBA8 TUBA1C TUBA1B H2AB1 EP300 TOP2A TUBB2B PHLDA1 TUBB2A H2AC8 H2AC6 H2AC7 ITGB3BP TUBAL3 TUBA3E TUBA3D CDKN1C TUBA3C SKP2 MCM10 DBF4 BUB1 RPA4 CLASP2 ABL1 CDK7 TFDP1 TYMS TFDP2 MNAT1 GSK3B E2F1 E2F3 H2BC26 H2BC21 CDKN1B H2BC17 H2BC12 H2BC13 KIF20A H2BC14 H2BC15 H2BC11 FBXL7 PTK6 CDK4 CDK2 HDAC1 H3-4 KIF18A RBBP4 GORASP1 EML4 GMNN USO1 ORC5 ORC4 ORC6 ORC1 ORC3 H2AZ2 ORC2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA NUP62 NUP37 NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP107 NUP188 EIF4E NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NXF1 NUP42 AAAS NUP160 ALYREF POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F2 KLKB1 F12 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing SFPQ PTK6 KHDRBS1 KHDRBS2 KHDRBS3 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) GAB1 NRAS PIK3R1 PLCG1 RAC1 CDK5 GRIN2B PTPN11 FRS2 SRC PIK3CA FRS3 NTF3 DOCK3 TIAM1 NTRK2 BDNF SOS1 CDK5R1 HRAS CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 PSMA5 CDC6 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 CCNE2 CCNE1 PSMD12 PSMD11 UBB PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ACTN1 PARVA LIMS1 ARHGEF6 TESK1 RSU1 PXN PARVB HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) SEM1 POLE4 POLE2 POLE3 RAD51B RTEL1 RAD51C KAT5 CHEK1 RAD9B RAD9A HUS1 EXO1 POLD1 DNA2 RHNO1 TOPBP1 RFC5 RFC3 RFC4 RFC2 ATRIP BARD1 RAD17 RBBP8 ATM ATR RAD50 BRCA1 RAD51 RMI2 RMI1 TOP3A RAD51D PCNA WRN UBA52 RPA1 RPA2 RPA3 RAD1 UBB POLK MRE11 POLE UBC RFC1 NBN MUS81 BRCA2 RPS27A RAD51AP1 SLX4 EME1 EME2 BRIP1 FIRRM FIGNL1 GEN1 SLX1B BLM XRCC2 POLH XRCC3 PALB2 SPIDR POLD3 POLD4 POLD2 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes H2AC14 AGPAT2 H2BC12L SCD PDK4 THRSP MED1 ACSL1 MED4 MED6 MED7 PAXIP1 PEX11A GPAM PPARGC1A PPARGC1B CREBBP H4C9 LPIN1 PNPLA2 CIDEC H2AC20 H2AX ASH2L MED16 MED17 MED12 MED14 MED13 MED10 CD36 H3-3B NCOA1 NCOA2 H3C8 ELOVL5 NCOA6 NCOA3 MED27 SIRT1 MED23 NCOR2 H2AJ MED24 AJUBA NR5A2 NCOR1 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H3C15 TBL1X H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 FABP4 H2AB1 EP300 PHLDA1 H2AC8 H2AC6 H2AC7 ADIPOQ TBL1XR1 KMT2D KMT2C RXRA LPL MED30 MED31 ABL1 CDK8 CDK5 DGAT2 DPY30 PAGR1 H2BC26 H2BC21 WDR5 KDM6A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CEBPA ACSS3 HDAC3 RBBP5 RB1 H2AC19 CCNC MGLL H2AZ2 LIPE INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling PIK3R2 LYN SYK INPPL1 PIK3CB IL5 PIK3R1 JAK2 HCK IL2RG FYN TEC RAPGEF1 JAK3 IL2RA IL2RB CRKL PIK3CA IL2 PTPN6 IL3 CRK IL5RA PIK3CD SOS1 GAB2 CBL CSF2RB INPP5D JAK1 SHC1 CSF2RA BLNK YWHAZ CSF2 PTPN11 IL3RA STAT5A PRKACA YES1 PIK3R3 STAT5B VAV1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling EPGN SHC1 NRAS EGF AREG EGFR HBEGF SOS1 HRAS TGFA EREG BTC LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production EP300 LRRFIP1 IRF3 CREBBP CTNNB1 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle VAV2 BCR PIK3R2 PIK3R1 CAV1 ARHGEF4 NGEF IQGAP2 IQGAP3 ARHGEF7 ARHGEF5 ABR ARHGEF6 AMIGO2 PIK3CA NCKAP1L WAS NOXO1 MCAM DOCK2 PAK1 NOX3 CDC42 FERMT2 NOX1 ARHGAP9 PAK6 PAK3 PAK5 ARHGAP1 PAK4 GIT2 ARHGAP4 EMD MYO9B MPP7 GMIP DLC1 CIT ESYT1 CDC42EP4 CDC42EP1 VAMP3 ARHGAP39 PIK3R3 SYDE2 ARHGAP44 ARHGAP42 FGD5 CHN2 ARHGDIA CHN1 ARHGDIB LBR YKT6 RALBP1 FARP2 CYBB RAB7A CYBA FARP1 ARHGAP45 MCF2 IQGAP1 DEF6 ARHGEF25 TAOK3 PAK2 ABI2 ARHGAP17 ARHGAP15 ARHGAP12 ARHGAP22 WASL ABI1 ARHGAP20 PKN2 ECT2 PKN1 ARHGEF39 ARHGAP29 NCF1 ARHGAP27 FAM13B ARHGAP26 NCF2 ARHGAP25 FAM13A ARHGAP24 NCF4 ARHGAP23 ARHGAP33 ARHGAP32 SLC1A5 ARHGAP31 ARHGAP30 DIAPH3 SWAP70 VRK2 MCF2L ARHGEF11 ARHGEF10 ARHGEF15 ARHGEF19 ARAP2 ARHGEF18 ARAP3 ARHGAP10 TIAM2 ABL2 SRGAP3 SRGAP2 ALS2 SRGAP1 NOXA1 GNA13 RASGRF2 SNAP23 BRK1 TAGAP FMNL1 PLEKHG3 DOCK7 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 SOS2 PARD6A TIAM1 SH3BP1 NHS ARHGAP5 ARHGAP21 WASF1 WASF2 WASF3 ERBIN CDC42BPA ARHGAP35 BAIAP2 DOCK10 RAC1 DOCK11 LEMD3 ARAP1 PLD1 BAIAP2L1 KTN1 OPHN1 NISCH PLD2 TMPO VANGL1 DEPDC1B SPATA13 ITGB1 DOCK1 EPHA2 SOS1 GARRE1 KALRN RACGAP1 LAMTOR1 CYFIP2 CYFIP1 NCKAP1 TRIO JAG1 TFRC WIPF1 WIPF2 WIPF3 DOCK6 DOCK5 DOCK4 DOCK3 PREX2 DOCK9 GIT1 PREX1 DOCK8 VAV3 VAV1 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping NOXA1 DVL1 DVL2 NOXO1 DVL3 FZD7 CYBA RAC1 WNT5A NOX1 JUN MAPK8 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO KIF3A SHH CSNK1A1 PTCH1 BOC GAS1 CDON IHH ARRB2 ARRB1 SMO EVC2 IQCE EFCAB7 DHH EVC DRC4 GRK2 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins AQP7 AQP9 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis ST3GAL1 ST3GAL2 ST3GAL3 MUC12 MUC15 MUCL1 MUC3A MUC5AC MUC3B ST6GALNAC2 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 ST6GALNAC3 MUC19 ST6GALNAC4 MUC5B MUC20 MUC21 ST6GAL1 ST3GAL4 MUC13 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions PQBP1 EIF4A3 SRRT CDC40 SRRM1 CLU SNRNP200 SRSF2 SRSF3 SRSF4 CTNNBL1 SRSF5 HNRNPC SRSF6 SRSF7 SRSF9 PRCC UBR4 F2 SRSF1 U2AF1 U2AF1L4 U2AF2 CCAR1 DHX38 SRSF11 CD2BP2 ALYREF CTR9 RTF1 PCBP1 PCBP2 RNPS1 SYMPK RBM10 PAF1 RETREG1 DHX15 NEK2 DHX16 HSP90AA1 WBP11 HNRNPUL1 RPL18 DDX3X DDX46 DDX42 LY96 RBM17 DYNLT1 BUD31 RBM22 DDX23 CSTF2T RIPK1 SMNDC1 TLR4 TAOK1 U2SURP CLP1 SNRPD2 SNRPD1 HNRNPF HNRNPA2B1 SNRPD3 SNRPA1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 ATG14 SF3A3 SF3A1 SF3A2 XAB2 SDC4 CLEC5A SDC2 SDC3 VTN PIK3R4 CHERP PUF60 SNRPB2 AQR NFKBIA C4B_2 CTNNB1 SDC1 PRPF19 PCF11 DAXX ELAVL1 PTBP1 HSPG2 IKBKE HNRNPH1 MAPKAP1 EFTUD2 HNRNPA1 HNRNPM ELAVL2 HSPA8 RPTOR GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 STAT2 TJP1 STING1 RICTOR MMP9 AGRN SNRPG SNRPE SNRPF SNRPB DDX5 H2AC19 H2AC14 MAVS HSP90AB1 NFKBIB MBL2 PRR5 GTF2F1 GTF2F2 MLST8 H4C9 PIK3C3 BECN1 H2AC20 MTOR H2AC17 H2AC12 H3C8 TAL1 NUDT21 PDCD6IP NCBP1 APOA1 NCBP2 H2AC25 FUS H2AC21 ISY1 PABPN1 BCAS2 C1S HNRNPA0 HNRNPA3 GPKOW CDC5L C4A CPSF7 H3C15 POLR2A SF3B1 POLR2B DHX9 POLR2C POLR2D H2BC9 H2BC8 H2BC5 POLR2G SUGP1 H2BC3 POLR2I H2BC1 POLR2J PEX19 PPIE NRBP1 H2AC1 H2AC8 HNRNPU H2AC6 HNRNPR H2AC7 UBE2I HNRNPL HNRNPK HNRNPD WDR33 H2BC18 PHF5A AUP1 PAPOLA IFIH1 TXNL4A SNRPN VIM TRIM25 PLRG1 SKIC8 DNAJC8 FIP1L1 PPIL1 SNRNP40 PPIL3 PPIL4 PPIL6 SRRM2 COG1 CRNKL1 H2BC26 CSTF3 CSTF2 SNW1 H2BC21 CSTF1 HNRNPH2 C1QA H2BC17 H2BC12 CWC25 H2BC13 CWC27 H2BC14 CWC22 H2BC15 PRPF6 H2BC11 PRPF8 RBMX CPSF4 CPSF1 CPSF3 CDC73 CPSF2 CWC15 CGAS EXOC1 LEO1 RBM5 GBF1 C4BPA C4BPB YBX1 CAMK2B POLR2E POLR2F CAMK2D FASN POLR2H CAMK2A POLR2K GRPEL1 POLR2L CAMK2G TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation NFKB1 APP NFKB2 UBE2N TAB3 NFKBIA TAB2 TAB1 TRAF2 ALPK1 NLRX1 CASP8 AGER S100A12 N4BP1 NFKBIB HMGB1 UBA52 NKIRAS1 CHUK NKIRAS2 IKBIP MAP3K7 LRRC14 USP14 TRAF6 NLRC5 IKBKB USP18 TP53 TIFA UBB IKBKG S100B RIPK2 SAA1 NOD1 NOD2 UBC RPS27A UBE2V1 RELA IRAK1 IRAK2 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer ALK STAT3 IRS1 WDCP PIK3R2 PIK3CB ZAP70 PIK3R1 TFG MYH9 MAPK9 MAPK8 ICOS FRS2 BCL11A MDM2 LMO7 PIK3CA DNMT1 PTPN6 TNRC6C ZC3HC1 MOV10 FOXM1 AGO3 GZMB AGO4 AGO1 AGO2 IL10RA PPM1B CARS1 EIF2AK3 BIRC6 SQSTM1 STRN TP53 PRF1 GCC2 JUNB MCL1 PLCG1 CLTC TYK2 EEF1G IRF4 TPR SEC31A ATIC CEBPB STAT5A CDKN1A SKP1 JUN FN1 PPFIBP1 VCL HIP1 KIF5B TWIST1 STAT1 RBX1 BCL2A1 MAPK1 DCTN1 MAPK3 IL10 PRKAR1A RRBP1 FRS3 RNF213 UBA52 NPM1 MSN KLC1 CUL1 CCNB1 RPS6 UBB HDAC1 UBC GRB2 IL22 RPS27A TPM4 RANBP2 TPM3 RB1 EML4 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases ATF1 PPP2R1B ELK1 MAPK7 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 DUSP6 DUSP7 MEF2A FOS MEF2C MAPK9 ATF2 MAPK8 MAPK1 MAPK10 MAPK3 MAPKAPK2 PPP2R1A PPP2R5D MAPK14 PPP2CA JUN MAPK11 PPP2CB RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription TEAD1 RUNX3 TEAD2 TEAD3 TEAD4 WWTR1 YAP1 CCN2 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle CAPZB PIK3R2 PLXNA1 PIK3R1 CAV1 DBN1 MOSPD2 ADD3 PLXNB1 MCAM PGRMC2 SLC4A7 EFHD2 PAK6 PAK5 ARHGAP1 EMD ESYT1 VAMP3 ARHGAP39 ARHGAP5 LMAN1 ARHGAP21 WHAMM LBR RAB7A ARHGAP35 LMNB1 CPNE8 LEMD3 TMPO VANGL1 ACTN1 DEPDC1B ARHGAP17 TOR1AIP1 ARHGAP12 FILIP1 RACGAP1 ARHGAP26 STEAP3 VAPB ARHGAP32 DIAPH1 AKAP12 GOLGA8R HINT2 DIAPH3 STBD1 VRK2 ANKFY1 RHOD DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling NCK1 PTK2 RAC1 TRIO SRC DCC DOCK1 WASL NTN1 ABLIM1 CDC42 ABLIM2 ABLIM3 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste GNAT3 TAS2R50 GRM1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS2R30 TAS1R2 TAS1R1 TAS2R31 TAS1R3 SCN1B TAS2R38 TAS2R39 TAS2R20 TAS2R7 TAS2R8 CALHM1 CALHM3 GNG13 GNB1 TRPM5 SCN3A ITPR3 GNB3 SCN2A TRPM4 SCN2B GRM4 TAS2R1 TAS2R10 TAS2R3 TAS2R13 TAS2R5 TAS2R4 TAS2R14 PLCB2 TAS2R16 SCN9A DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) CP SLC40A1 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements H2AC14 TRIM28 H2BC12L DPF1 DPF2 DPF3 ZNF610 SMARCC1 SMARCC2 ZNF28 ZNF273 ZNF708 ZNF264 ZNF141 H4C9 SETDB1 ZNF382 SS18L1 SMARCA2 SMARCA4 ZNF816 H2AC20 ZNF30 ZNF136 ZNF257 H2AX H3-3B H3C8 SS18 ACTL6A PPHLN1 H2AJ H3C15 ZNF224 MBD3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 GATAD2B GATAD2A ZNF33A ZNF354A MPHOSPH8 ZNF454 ZNF331 H2AB1 MTREX ZNF324 ZNF320 H2AC8 ZNF680 H2AC6 H2AC7 UBE2I SPOCD1 ZNF93 ZNF317 ZCCHC8 SUMO2 TASOR ZNF669 ZNF547 ZNF425 MORC2 CBX5 ZNF418 ZNF778 ZNF534 PIWIL4 CHD4 CHD3 DNMT3L H2BC26 BCL7A ZNF649 H2BC21 BCL7C BCL7B ZNF765 RBM7 DNMT3A ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 ZNF519 H2BC11 C19orf84 SMARCD1 HDAC2 SMARCD2 SMARCD3 HDAC1 MTA1 RBBP4 SMARCB1 RBBP7 MTA2 EHMT2 MTA3 H2AC19 EHMT1 ATF7IP SMARCE1 ACTB H2AZ2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation GALNT3 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP MBD4 H2BC14 SMUG1 H2BC15 NEIL2 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 MPG H2BC1 TDG H2AX H2AC19 NTHL1 H2BC26 NEIL3 H2AB1 H2AZ2 NEIL1 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RPL24 EIF4A3 RPL27 CASC3 RPL26 MAGOH RPL29 RPL28 RPL41 CDC42 RPL3L CUL2 RBM8A UPF3B MAGOHB RNPS1 PRKACA CAP1 CAP2 RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 PAK2 RPS15 CXCL12 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 PSMD12 RPS13 PSMD11 UBB RPS12 PSMD14 PSMD13 UBC RPLP1 PSMA7 RPLP0 PSMB6 RPS27A PSMD8 CLASP1 PSMB7 PSMB4 PSMD6 RPS4Y2 RPLP2 PSMB5 PSMD7 VASP PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ENAH RPS4Y1 FLRT3 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 ABL2 SRGAP3 PSMC3 SRGAP2 PSMA1 SRGAP1 RPS26 PSMA2 RPS25 PSMC4 RPS28 PSMC1 RPS27 PSMC2 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 NRP1 MSI1 HOXA2 ISL1 RPL37A COL4A5 GSPT2 NCK2 GSPT1 UPF3A NCK1 LHX3 LHX2 LHX4 RPL36A LHX9 USP33 PRKCA ROBO1 UPF2 ETF1 RPL35A ZSWIM8 PABPC1 SLIT1 RPL22L1 EVL SOS2 SRC RPS27L RPS15A EIF4G1 GPC1 RPS3 PRKACG PRKACB RPS2 RBX1 FAU PFN1 PFN2 SOS1 RPS9 RPS7 RPS8 RPS5 PRKAR2A RPS6 RPSA RPL39L DAG1 RPL10L RPL10A RPS4X DCC PAK1 LDB1 NTN1 RPS3A AKAP5 RPL23A PAK6 PAK3 PAK5 PAK4 MYO9B ARHGAP39 NELL2 SLIT3 ELOB ELOC NCBP1 RPL27A NCBP2 RPL13A CXCR4 RPL18A RPL36AL PPP3CB CLASP2 ABL1 RAC1 RHOA RPL26L1 RPL4 ROBO2 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL9P9 RPL8 RPL6 RPL7 RPL36 SLIT2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) MSH2 PMS2 MLH1 MSH6 MSH3 PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway PGD RPE PRPS2 TALDO1 PRPS1 G6PD PGM2 RPIA PGLS RPEL1 TKT RBKS DERA SHPK PRPS1L1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling TAB3 TAB2 TAB1 CHUK IKBKE ADAM17 IKBKB TNF IKBKG RACK1 ULK1 MAPKAPK2 SMPD3 SMPD2 UBE2D1 UBE2L3 TRADD TRAF1 TRAF2 RNF31 TNFAIP3 CASP8 XIAP OTUD7B SPATA2 SHARPIN RIPK1 USP4 FADD USP21 STUB1 UBA52 MIB2 UBE2D2 TNFRSF1A TBK1 OPTN CYLD RBCK1 OTUD1 MAP3K7 BIRC2 BIRC3 UBB UBC RPS27A UBE2D3 USP2 TAX1BP1 BAG4 SPPL2B SPPL2A CLIP3 NSMAF OTULIN RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 CCNK CCNT2 CCNT1 GTF2B SUPT16H GTF2F1 GTF2F2 SUPT4H1 GTF2E1 GTF2E2 CDK7 CTR9 SKIC8 RTF1 MNAT1 PAF1 ELOA2 SUPT5H CDK9 TAF4B ELL TAF7L ELOA NELFB ELOB NELFCD NELFA ELOC NELFE TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 EAF1 CDC73 EAF2 TAF9 TAF1L POLR2A POLR2B POLR2C POLR2D LEO1 POLR2G POLR2I TAF9B POLR2J GTF2H1 SUPT6H GTF2H2 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 AFF4 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH SSRP1 TAF8 POLR2K POLR2L TAF7 MLLT1 MLLT3 TCEA1 IWS1 TAF6 TAF5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 BUB1B UBB CDC20 UBC BUB3 MAD2L1 RPS27A NEK2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 ROBO1 SRGAP3 ARHGAP39 RAC1 SLIT2 SRGAP2 CDC42 SRGAP1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora PPP1R3C UBB NHLRC1 GYG1 EPM2A UBA52 GYS1 UBC RPS27A DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription SNW1 HEY2 EP300 MAMLD1 NOTCH1 SMAD3 ACTA2 MAML2 MAML1 RBPJ HES5 MAML3 NOTCH2 KAT2B KAT2A NOTCH4 HES1 FLT4 CREBBP HEY1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions LAMC3 SGCE SGCD SGCA SGCB SGCG SNTA1 LAMA2 SDC1 LAMA4 NRXN1 LAMB2 ITGB3 SGCZ PDGFB NTN4 ITGB5 SNTB1 SNTB2 ITGAV HSPG2 TGFB1 PDGFA PRKCA LAMC2 LAMC1 TRAPPC4 ITGB4 ACTN1 AGRN ITGB1 LAMA1 TTR ITGA6 DTNA DTNB FGF2 SSPN DDR1 CASK LAMA5 LAMA3 ITGA2 DDR2 DRP2 DMD LAMB3 LAMB1 TNC DAG1 SDC4 UTRN SDC2 SDC3 VTN THBS1 SNTG2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation VAV2 CD3G FCGR3A SYK FCGR1A FCGR2A HSP90AB1 NCKAP1L WAS PAK1 CDC42 ARPC1B ARPC1A MYO9B ACTG1 HSP90AA1 CFL1 ABI2 WASL ABI1 IGHV3-23 NCKIPSD IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 NF2 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 LIMK1 BRK1 V1-7 V5-1 ABL1 V1-5 V1-3 IGKV3D-20 NCK1 V5-6 ACTR3 IGLV3-19 IGKV2-30 ACTR2 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 MYH2 V4-6 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 WASF1 WASF2 WASF3 BAIAP2 RAC1 MAPK1 MAPK3 ELMO1 BTK ELMO2 DOCK1 CRK PTK2 CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 VAV3 IGHG3 IGHG4 IGHG1 ACTB IGHG2 VAV1 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling PSMA5 HLA-DQB2 SEM1 CD3G PSMA6 HLA-DRB1 PSMA3 HLA-DQB1 PIK3R2 PSMC5 PIK3CB PSMA4 PIK3R1 PSMC6 PSMC3 PSMA1 PSMA2 UBE2N PSMC4 NFKBIA PSMC1 TAB2 PSMC2 PIK3CA CHUK PDPK1 TRAF6 IKBKB IKBKG PTEN RIPK2 MALT1 LCK TRAT1 BTRC UBE2D1 RELA SKP1 FBXW11 NFKB1 UBA52 UBE2D2 MAP3K7 CD4 CUL1 INPP5D PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC TRAC CDC34 PSMA7 CD3E CD3D PSMB6 RPS27A PSMD8 TRBV12-3 PRKCQ UBE2V1 TRAV29DV5 CARD11 PSMB7 TRBV7-9 TRBC1 PSMB4 PSMD6 HLA-DQA2 PSMB5 HLA-DQA1 PSMD7 HLA-DPA1 PSMB2 PSMB3 TRAV19 PSMD2 BCL10 HLA-DRB5 PSMD3 HLA-DRB4 PSMB1 PSMD1 HLA-DPB1 TRAV8-4 HLA-DRA ADRM1 HLA-DRB3 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs RHOB PPP1R12A MYL6 MYL9 CFL1 MYH9 RHOA PPP1CB PPP1R12B ROCK2 PAK1 LIMK2 ROCK1 LIMK1 MYH14 MYH11 RHOC MYL12B MYH10 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription RHEB ATF2 EGR1 RRAGA SNAI1 RRAGC PPARG RRAGB SNAI2 RRAGD MLST8 TP53 REST BMI1 ATN1 SALL4 MAF1 RING1 HDAC5 RNF2 HDAC7 EZH2 CBX8 CHD4 MTOR CHD3 PHC2 CBX6 PHC1 JUN CBX4 RPTOR CBX2 PHC3 KDM1A EED MAPK1 MAPK3 HDAC2 LAMTOR2 LAMTOR1 HDAC3 LAMTOR4 MECOM LAMTOR3 MBD3 LAMTOR5 HDAC1 SUZ12 MTA1 RBBP4 NR2E1 RCOR1 GATAD2B GATAD2A RBBP7 MTA2 SLC38A9 MTA3 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling MKNK1 SPRY2 MAPK1 FRS2 BRAF MAPK3 FGF1 FGF4 FGF16 UBA52 FGF9 FGF18 FGF20 FGF23 CBL FGF6 FGF2 KLB UBB UBC FGF19 FGFR4 RPS27A PTPN11 PPP2R1A PPP2CA PPP2CB PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNA2 CHRND CHRNB3 CHRNA5 CHRNA4 CHRNG CHRNA6 CHRNE LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling EP300 NCOA1 SCD KDM1A NR1H3 MYLIP ANGPTL3 NR1H2 TBL1XR1 NCOR2 TNRC6C RXRA MOV10 AGO3 AGO4 NCOR1 AGO1 NRIP1 AGO2 KDM3A TNRC6A UGT1A3 TNRC6B KDM4A ABCA1 APOC1 PLIN1 GPS2 APOC4 TBL1X HDAC3 ABCG8 ABCG5 APOD FABP6 RXRB APOC2 KDM1B APOE FASN PCK1 CETP ARL4C EEPD1 ABCG1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs NRAS RALA KIDINS220 MAP2K1 MAP2K2 MAPKAPK3 RAP1A RAPGEF1 MAPK1 SHC3 FRS2 BRAF CRKL MAPK3 SHC2 RALGDS CRK RALB MAPK13 SOS1 YWHAB RIT1 RIT2 SHC1 NTRK1 MAPKAPK2 NGF MAPK12 MAPK14 HRAS MAPK11 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins PCSK6 PCSK5 FURIN NGF HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE GPCPD1 PLA2G4C HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) RMI2 ERCC4 RMI1 ERCC1 TOP3A WRN RAD52 KAT5 RAD9B RAD9A LIG1 RPA1 HUS1 RPA2 EXO1 ABL1 DNA2 RPA3 RHNO1 TOPBP1 RAD1 RFC5 RFC3 RFC4 RFC2 MRE11 ATRIP NBN BARD1 BRIP1 RAD17 RBBP8 ATM ATR BLM RAD50 BRCA1 RAD51 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria BMF DYNLL2 MAPK8 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis NOS2 CORO1A DUSP16 HGS ATP6V1H RAB7A CTSG PGK1 MAPK1 GSK3A SFPQ MAPK3 RNF213 KPNA1 UBA52 ENO1 B2M UBB TRIM27 MRC1 VPS33B UBC RPS27A TLR2 LTF RAB5A KPNB1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation EP300 IFNA21 MAVS IFNB1 TRAF2 IFNA5 IFNA4 IFNA7 IFNA6 TBK1 IFNA1 IFNA2 IRF3 IFNA8 IFNA14 TRIM4 CREBBP TRAF6 IFIH1 IRF7 IKBKE IFNA16 TRIM25 IFNA17 RIGI IFNA10 SIKE1 TANK RNF135 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin STAG1 STAG2 PDS5B MAU2 PDS5A SMC1A WAPL SMC3 RAD21 NIPBL MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility TNS3 LAMC3 RAC1 ITGA3 RAP1A RAPGEF1 LAMA2 LAMA4 CRKL LAMB2 ITGB1 LAMA1 CRK LAMA5 RAP1B HGF DOCK7 LAMA3 GAB1 MET PTK2 ITGA2 LAMB3 LAMB1 SRC LAMC2 LAMC1 TNS4 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins GPC1 LRP2 LRP10 GPC3 LRP12 LRP8 GPC2 GPC5 RETSAT GPC4 GPC6 APOA2 RDH11 APOA1 VKORC1L1 APOA4 SDC1 TTPA AGRN LPL TTR BCO2 UBIAD1 GPIHBP1 HSPG2 BCO1 PNLIP APOB VKORC1 APOC3 PLB1 APOC2 LRAT AKR1C1 AKR1B10 APOM AKR1C3 SDC4 APOE LRP1 SDC2 AKR1C4 SDC3 RBP4 RBP2 RBP1 LDLR CLPS MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle SLC25A13 SLC25A18 GOT1 MDH1 GOT2 SLC25A12 MDH2 SLC25A11 SLC25A22 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle VAV2 BCR PIK3R2 DAAM1 ARHGEF3 PIK3R1 CAV1 ARHGEF4 NGEF ARHGEF1 IQGAP3 ARHGEF2 ARHGEF7 ARHGEF5 ABR STARD13 JUP MCAM DOCK2 PGRMC2 EMC3 ARHGAP9 ARHGAP8 ARHGAP1 BCAP31 ARHGAP6 ARHGAP4 AAAS CAVIN1 MYO9B MYO9A GMIP DLC1 CIT TJP2 RTKN VAMP3 PKN3 ARHGAP39 ARHGAP44 LMAN1 ARHGAP42 ARHGAP40 ACBD5 ARHGDIA ARHGDIB STX5 ARHGEF40 LBR YKT6 FARP1 ARHGAP45 MCF2 IQGAP1 ABCD3 DEF6 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 VMA22 ARHGAP22 ARHGAP20 RHPN1 RHPN2 PKN2 ECT2 PKN1 ARHGAP29 MACO1 ARHGAP28 ARHGAP26 FAM13A ARHGAP24 ARHGAP23 VAPB STK10 ARHGAP32 SLK DIAPH1 ARHGAP31 ARHGAP30 DIAPH3 SOWAHC ARHGEF10L TEX2 MCF2L OBSCN FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ATP6AP1 ARHGEF17 DDRGK1 ARHGEF19 ARAP2 ARHGEF18 ARAP3 ARHGAP10 SRGAP1 STOM ARHGAP11A ARHGAP11B RASGRF2 SNAP23 TAGAP FMNL3 ACTC1 PLEKHG3 PLEKHG4 PLEKHG6 ROCK2 TIAM1 ROCK1 ARHGAP5 ARHGAP21 FLOT2 PCDH7 ERBIN ARHGAP35 PLEKHG5 ARAP1 PLD1 RHOA KTN1 OPHN1 TMPO VANGL1 DEPDC1B HMOX2 TMEM87A KALRN SCFD1 RACGAP1 NET1 ANLN FAF2 TRIO TFRC AKAP13 C1QBP STBD1 PREX2 PREX1 VAV3 STARD8 VAV1 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EP300 PHC3 ACTL6A SMARCC1 SMARCC2 ARID1A ARID1B AUTS2 PBRM1 ACTL6B HIPK2 PCGF5 SMARCD1 CBFB SMARCD2 BMI1 RUNX1 RYBP SMARCD3 SMARCA2 RING1 SMARCA4 RNF2 CSNK2A1 YAF2 CSNK2A2 SMARCB1 ARID2 CBX8 PHC2 CBX6 PHC1 CSNK2B SMARCE1 CBX4 CBX2 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2AC14 RHOB H2BC12L MYL6 H2AC8 MYL9 H2AC6 H2AC7 MYH9 AR YWHAQ YWHAH PAK1 PDPK1 YWHAB KDM4C H4C9 YWHAZ YWHAE KLK2 H2AC20 PPP1CB PPP1R12B H2AX PKN3 YWHAG H2BC26 H2BC21 H3-3B PPP1R12A NCOA2 PPP1R14A H3C8 KDM1A RAC1 RHOA H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 MYH14 MYH11 KLK3 PKN2 MYL12B MYH10 PKN1 H3C15 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CDC25C H2AC19 H2AB1 RHOC H2AZ2 SFN LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization HSD17B13 HILPDA CIDEC FITM1 FITM2 CIDEA ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R2 CYB5R1 RHAG CYB5R4 CA1 CYB5RL AQP1 CA2 CA4 SLC4A1 HBA2 HBB GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling GP9 FLNA GP1BA PIK3R1 YWHAZ VWF GP1BB RAF1 GP5 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall PIK3R2 PIK3CB PIK3R1 IGHA1 IGHA2 SLC16A1 JCHAIN L1CAM GP6 PIK3CA PROS1 PTPN6 ITGB3 THBD PF4V1 CD177 ITGAV TGFB1 F2 MERTK PROCR PECAM1 PLCG1 PROC TNFRSF10B TNFRSF10A MIF IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 ANGPT4 V2-11 ANGPT2 IGHV3-30 ANGPT1 V3-4 SHC1 CEACAM6 V3-3 DOK2 V2-17 GRB14 CEACAM8 V3-2 TEK IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 SLC7A11 IGKV2D-28 JAM2 IGKV4-1 JAM3 IGHV7-81 SLC7A10 V1-11 IGKV2D-30 CD58 V1-16 SDC4 V1-13 IGHV4-59 IGHV1-69 SDC2 SDC3 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 SLC7A6 IGLV1-44 SLC7A7 IGKV3-15 SLC7A8 IGKV3-11 LYN SLC7A9 V2-8 VPREB3 V1-20 VPREB1 IGKV2D-40 PSG1 IGHV3-11 PSG3 IGHV3-13 ITGAX PSG2 CD74 IGKV1D-16 PSG9 IGLV7-43 FCAMR MAG IGKV1D-12 ITGA3 PSG8 PSG5 IGLV1-51 PSG4 IGLV2-23 PSG7 SDC1 IGKV3-20 PSG6 IGHV4-34 GYPA TSPAN7 IGHV1-2 BSG GYPC IGHV1-46 ATP1B3 GYPB IGHV4-39 CD99L2 ATP1B2 IGKV2-29 GLG1 ATP1B1 IGKV2-28 SLC3A2 CD48 IGLC3 PICK1 SELPLG IGLC1 IGLL1 IGLC2 SLC16A8 V1-9 V5-4 SLC16A3 PSG11 V1-7 V5-1 SELE SELP V1-5 ESAM V1-3 SPN IGKV3D-20 V5-6 CD2 CD244 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC LCK IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 ITGAL IGKV5-2 IGKV1-5 IGLC6 ITGA4 CEACAM3 ITGA5 GPC1 MMP1 CXADR GRB7 SOS1 ITGA6 CD44 INPP5D APOB CD84 ITGB2 F11R YES1 HRAS TNFRSF10D NRAS CAV1 FYN CEACAM5 JAML CD99 SELL TREM1 CEACAM1 PTPN11 FN1 SLC7A5 PF4 IGHM CD47 SIRPG SIRPA PPIL2 ITGAM GAS6 EPCAM PPIA OLR1 ITGB1 FCER1G FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes DDIT3 EP300 NFYA NFYB NFYC BBC3 BCL6 FASLG PINK1 CITED2 STK11 FOXO4 FOXO3 FOXO1 CREBBP BCL2L11 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival IKBKB UBB NFKB1 UBC NFKBIA NGFR RPS27A NGF UBA52 RELA IRAK1 SQSTM1 TRAF6 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 EP300 PSMA5 SEM1 BCL2 PSMA6 PSMA3 SOD3 PSMC5 PSMA4 G6PD PSMC6 BCL2L1 PSMC3 PSMA1 PSMA2 PSMC4 MYC PSMC1 PSMC2 TXN SP1 SRXN1 SQSTM1 CCL2 NQO1 CREBBP PGD GCLC PDGFA EGF PRDX1 MAFK AREG TXNRD1 GCLM NFE2L2 GSK3B ABCG2 BTRC RELA SKP1 KEAP1 ABCF2 CDKN2A PRKAA2 NFKB1 GSTA3 RBX1 GSTA1 HMOX1 UBA52 ME1 ABCC3 ABCC1 CUL1 BACH1 PSMD12 CHD6 TALDO1 PSMD11 UBB NOTCH1 PSMD14 PSMD13 UBC SLC7A11 PSMA7 PSMB6 RPS27A PSMD8 IDH1 PSMB7 MAFG PSMB4 PSMD6 ATF4 PSMB5 PSMD7 TKT PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins NUP62 NUP37 PIAS4 NDC1 UBE2I SEC13 NUP133 NUP107 MDM2 NUP188 PIAS1 NUP50 SUMO1 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 TRIM27 NUP42 AAAS NUP160 POM121C VHL NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 PML NUP35 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response FLNA RNASEL PDE12 ABCE1 RIGI OAS2 OASL OAS1 OAS3 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium EXOC4 RAB11FIP3 EXOC3 EXOC6 RAB3IP EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 ARF4 PKD2 RHO PKD1 GBF1 RAB11A CNGA2 CNGA4 EXOC8 EXOC7 RAB8A SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection NLRP3 UVRAG CAV1 MAVS PALS1 GSK3A ST6GALNAC2 PRKCSH RPS4X YWHAQ YWHAH PDPK1 RPS3A IRF3 CHMP4C TRAF3 CHMP4B TRAF6 CHMP4A PIK3C3 ST6GALNAC3 RUNX1 ST6GALNAC4 BECN1 YWHAE GANAB VHL PCBP2 GALNT1 CHMP2B CHMP2A YWHAG RELA NFKB1 RPS15 RPS14 CHMP3 RPS17 UBA52 RPS16 CHMP6 TBK1 CHMP7 RPS19 RPS18 RPS11 RPS10 RPS13 UBB RPS12 BST2 UBC ST6GAL1 MOGS RPS27A ACE2 RPS4Y2 PIK3R4 IFIT1 PPIH RPS4Y1 IFIT3 PPIG IFIT2 ST3GAL4 RCAN3 SFN EP300 ST3GAL1 ST3GAL2 ST3GAL3 RIPK3 PARP16 BCL2L1 PSMC6 PARP14 UBE2I PARP10 RPS26 RPS25 NFKBIA RPS28 PYCARD RPS27 RPS29 RPS20 CASP1 NMI RPS21 RPS24 RPS23 SUMO1 SP1 YWHAB MAP1LC3B PPIA IFIH1 IKBKE TOMM70 TRIM25 PARP6 HNRNPA1 PARP4 RIGI SFTPD YWHAZ EEF1A1 PARP9 GSK3B PARP8 NPIPB3 SIKE1 CANX KPNB1 TLR7 RPS27L TMPRSS2 RPS15A CTSL RPS3 MGAT1 RPS2 STING1 FAU NPM1 KPNA2 RPS9 RPS7 RPS8 PPIB RPS5 RPS6 SMAD4 RPSA SMAD3 ZCRB1 ITCH RB1 VCP FKBP1A DDX5 TKFC IRAK2 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 GYG2 GYS2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence TERT MCM5 LIG1 MCM2 BRCA1 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC NFE2L2 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 GSK3B PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PSMD3 PSMB1 PSMD1 SKP1 ADRM1 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism ST3GAL1 ST3GAL2 ST3GAL3 HEXB GNS B4GALT2 HEXA B4GALT3 GLB1L3 B3GNT7 CHST1 GLB1L2 GLB1L B3GNT4 GLB1 B3GNT3 CHST5 SLC35D2 B3GNT2 CHST2 CHST3 FMOD OGN KERA LUM OMD B4GALT1 ACAN B4GALT6 GALNS B4GAT1 B4GALT4 B4GALT5 PRELP CHST6 ST3GAL6 ST3GAL4 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC47A2 SLC14A1 RUNX1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC22A4 SLC22A5 SLC67A1 SLC22A3 RSC1A1 SLC22A2 SLC22A1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer IRS1 PIK3R2 PIK3CB PIK3R1 FYN ESR1 FRS2 PIK3CA FLT3LG PDGFB CD19 CD28 PDGFRA STRN FLT3 GAB2 FGF6 CD86 HGF KLB CD80 GAB1 MET EGF ERBB2 AREG PDGFRB EGFR FGF19 FGFR4 LCK TRAT1 PIK3AP1 PTPN11 EPGN SRC FGF7 FGF22 FGF3 PIK3R3 NTRK2 FGF10 PIK3R6 BDNF PIK3R5 RAC1 NRG1 NRG2 EREG BTC NRG3 FGF1 NRG4 FGF4 FGF16 FGF9 HBEGF FGF18 FGF20 PIK3CD PIK3CG FGF23 KIT NTRK3 FGF2 ESR2 TGFA IRS2 RAC2 NTF3 RHOG VAV1 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs SBF1 SBF2 ALS2 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TRAPPC2L AKT1 GAPVD1 RAB32 RAB31 RAB5B RAB35 ULK1 YWHAE RAB38 DENND6B RIN3 DENND6A RAB9A RIN1 RIN2 RAB9B RAB6B TRAPPC2 TRAPPC3 TRAPPC1 RAB5A ANKRD27 DENND4B CHM RAB8A RAB6A CCZ1B DENND4A TRAPPC4 DENND4C HPS1 TRAPPC5 RAB39A CCZ1 RAB5C RAB3IP HPS4 RAB27A RAB7A RAB39B RAB27B TRAPPC8 TRAPPC9 MON1A MON1B DENND1C DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D DENND2C DENND2B DENND2A RAB3IL1 TRAPPC6A TRAPPC6B AKT2 AKT3 RAB7B RAB1A RAB1B DENND3 RAB21 ALS2CL RAB14 CHML RIC1 TRAPPC10 RGP1 RAB10 RAB12 RAB13 RAB18 RAB3GAP2 RAB3GAP1 RAB3A EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation FGFR1 SNAI1 EOMES TBXT DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression PTK6 HIF1A PELP1 EPAS1 NR3C1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases PPFIBP1 PTPRS PTPRD PPFIBP2 SLITRK2 SLITRK1 IL1RAPL2 SLITRK4 SLITRK6 LRRC4B PTPRF SLITRK3 PPFIA1 SLITRK5 PPFIA4 NTRK3 IL1RAPL1 PPFIA3 PPFIA2 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition HSP90AB1 FOXM1 MYBL2 WEE1 HMMR HJURP YWHAE CEP57 CETN2 MIS18BP1 CEP164 CCP110 PPP2R2A PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA CEP290 NINL YWHAG RAB8A SKP1 FZR1 CDK5RAP2 OFD1 HSP90AA1 BORA CEP135 PPP1R12A FBXW11 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 SGO1 HAUS5 CSNK1E TUBG1 GTSE1 DYNLL1 FKBPL CKAP5 TUBA4A CENPF HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 UBA52 AJUBA OPTN PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 PSMD12 CCNB1 PSMD11 UBB TUBG2 MZT2B HAUS8 PSMD14 PRKAR2B MZT2A PSMD13 NME7 HAUS7 TUBGCP2 UBC CEP70 MZT1 CEP72 TUBGCP5 FBXL18 CEP192 TUBGCP6 PSMA7 TUBGCP3 PCNT TUBGCP4 PSMB6 RPS27A PSMD8 CEP76 CLASP1 CEP78 PSMB7 OBI1 PLK4 PSMB4 PSMD6 LCMT1 DYNC1H1 PPME1 ODF2 PSMB5 PSMD7 CDK11A CEP152 TICRR PSMB2 NDE1 CDK11B PLK1 PSMB3 PSMD2 TUBB4B PSMD3 TUBB4A PSMB1 NEDD1 PSMD1 ALMS1 CDK1 CEP41 CEP43 ADRM1 EP300 PSMA5 SEM1 PSMA6 PHLDA1 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 CDC25B PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PPP2R3B PKMYT1 XPO1 TP53 CDK7 TPX2 MNAT1 CDKN1A PPP2CA PPP2CB PPP2R1B RBX1 LIN54 LIN37 LIN9 LIN52 FBXL7 CDK2 CCNA2 CCNA1 RBBP4 CDC25C CCNH TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters TFB2M MTERF1 POLRMT TFAM DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass CUL4A POLE4 POLE2 POLE3 CUL4B PCNA RBX1 WDR48 UBA52 RPA1 UBA7 RPA2 RCHY1 UBE2L6 POLD1 REV1 ISG15 MAD2L2 REV3L RPA3 TRIM25 RFC5 UBB RFC3 RFC4 POLK RFC2 UBC POLE RFC1 UBE2B USP1 RPS27A USP10 PCLAF DDB1 USP43 SPRTN POLI POLH NPLOC4 VCP DTL UFD1 POLD3 RAD18 POLD4 POLD2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNA1 CHRNA7 CHRNB2 CHRNA9 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRND CHRNA5 CHRNA4 CHRNA6 CHRNG CHRNE RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions EP300 IFNA21 CX3CR1 MAVS MED1 MAP1B MED4 SDC1 MED6 MED7 IFNA5 IFNA4 CDK19 IFNA7 IFNA6 MED30 IFNA1 MED31 IFNA2 IRF3 CUL5 UBE2L6 IFNA8 ISG15 HSPG2 CREBBP IFIH1 HERC5 JAK1 BCAP31 TRIM25 ARIH1 BECN1 RIGI CDK8 MED19 TYK2 MED15 MED18 MED11 EIF2AK2 TLR2 MED16 MED17 TLR7 MED12 MED14 TLR3 MED13 MED26 MED10 MED29 MED28 GPC1 MED22 ELOB MED25 GPC3 GPC2 ELOC GPC5 MED21 TLR6 GPC4 LY96 GPC6 IFNB1 MED27 RBX1 STAT2 MED23 H2BC15 CD14 AGRN MED24 UBA52 TLR4 MED20 IFNA14 IFNA16 IFNA17 UBB UBC CD209 OAS2 RPS27A CLEC4M SDC4 IFNA10 IFNAR1 SDC2 SDC3 MED8 CCNC MED9 MED13L SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes CATSPER1 CATSPER3 KCNU1 HVCN1 CATSPER2 CATSPERB CATSPER4 CATSPERD CATSPERG ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement RNF19B VAV2 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 JAK2 ARHGEF4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 JUP CDC42 CDH11 CTNNA1 JAK1 CTNND1 CBLL1 TYK2 SRC TIAM1 RELA CTSS CTSL VCL FARP2 NFKB1 IL6 RAC1 CTSB TRAF7 XIAP ELMO1 DOCK1 UBA52 HACE1 BIRC2 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 IL6ST PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 IL6R PSMD3 PSMB1 PSMD1 ADRM1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 F8 TPST2 TPST1 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling LAMTOR2 LAMTOR1 RPS6 LAMTOR4 LAMTOR3 LAMTOR5 AKT1S1 RHEB EIF4EBP1 EIF4E EIF4B MTOR FKBP1A RRAGA SLC38A9 RRAGC RRAGB EEF2K RRAGD RPTOR MLST8 EIF4G1 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling STAT3 PTPN9 PTPN5 PTPN2 PTPN7 SMAD3 PTPN13 PTPN12 PTPN20 PTPN23 PTPN11 CASP1 PTPN14 SIGIRR PTPN6 PTPN4 TBK1 IL37 IL18BP IL18R1 PTPN18 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 EP300 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 HDAC4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 MYC PSMC1 PSMC2 CTNNB1 MDM2 ZFHX3 FOXO3 BRD2 CREBBP TGFB1 CCND1 CBFB KRAS RUNX3 TP53 RUNX1 MAML2 MAML1 SRC MAML3 ITGAL CDKN1A TCF7L1 ITGA4 TEAD1 SNW1 TCF7L2 MAMLD1 TEAD2 TEAD3 CDKN2A TEAD4 KAT2B KAT2A UBA52 CCN2 PSMD12 PSMD11 UBB NOTCH1 TCF7 SMAD4 PSMD14 SMAD3 PSMD13 SMURF2 LEF1 UBC SMURF1 RBPJ SPP1 PSMA7 PSMB6 RPS27A PSMD8 JAG1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 WWTR1 PSMD2 PSMD3 PSMB1 PSMD1 HES1 YAP1 BCL2L11 ADRM1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 CCND3 PSMA1 PSMA2 PSMC4 MYC PSMC1 PSMC2 TNRC6C MOV10 AGO3 PAK1 AGO4 FOXO3 AGO1 FOXO1 CDC42 AGO2 DNAJB1 TNRC6A HSPB1 TNRC6B PAK3 XPO1 CDC42EP5 CDC42EP3 CDC42EP2 PRKACA JUN PRKACG RAC1 PRKACB NCOA3 PAK2 SEPTIN7 CDC14A CDC14B ETV4 UBA52 IGF2BP1 MAPK6 MAPK4 KALRN PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 MAPKAPK5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 RAG2 ADRM1 RAG1 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex PER2 PER1 CSNK1D PER3 CDK5 CSNK1E CRY2 CRY1 PPP1CB CSNK2A1 PPP1CC CSNK2A2 PPP1CA CSNK2B UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle CPS1 ARG1 TP53 NMRAL1 OTC ARG2 SLC25A2 NAGS SLC25A15 ASL ASS1 SIRT5 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones INHA LHB CGA INHBB INHBC INHBA TSHB INHBE CGB8 FSHB PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer IRS1 PIK3R2 PIK3CB PIK3R1 FYN FRS2 MDM2 GSK3A PIK3CA FLT3LG PDGFB CD19 PRR5 PDPK1 CD28 STRN FLT3 GAB2 MLST8 CD86 KLB CD80 EGF ERBB2 PDGFRB FGF19 EGFR FGFR4 AKT1S1 TRAT1 RPS6KB2 PIK3AP1 PTPN11 EPGN PIK3R3 MTOR PIK3R6 PIK3R5 AKT2 AKT3 IRS2 BAD ESR1 FOXO6 FOXO4 CHUK FOXO3 FOXO1 PDGFRA FGF6 AKT1 HGF MAPKAP1 GAB1 MET PTEN AREG LCK SRC FGF7 GSK3B FGF22 FGF3 CDKN1A FGF10 NTRK2 BDNF TSC2 CDKN1B RAC1 NRG1 NRG2 EREG BTC NRG3 FGF1 NRG4 RICTOR FGF4 FGF16 FGF9 FGF18 HBEGF FGF20 PIK3CD FGF23 PIK3CG KIT NTRK3 FGF2 ESR2 NR4A1 TGFA RAC2 NTF3 CASP9 RHOG VAV1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 ITGB3BP H4C9 SMARCA5 HJURP RSF1 MIS18BP1 OIP5 CENPW H2AC20 MIS18A H2AX CENPA CENPC H2BC26 H2BC21 CENPT CENPU H2BC17 H2BC12 KNL1 H2BC13 H2BC14 CENPH H2BC15 CENPI H2AJ NPM1 H2BC11 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 H2BC1 CENPX RUVBL1 RBBP7 H2AC19 H2AB1 H2AZ2 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE PLBD1 PLA2R1 ABHD4 PLA2G3 PLA2G5 PLA2G6 PLA2G2F PLA2G2D PLA2G2E PNPLA8 PLA2G2A MBOAT1 MBOAT2 LPCAT4 LPCAT3 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G10 PLA2G1B DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 NRAS PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 REL PPP3CA NFKBIA PSMC1 PPP3CB PSMC2 NFKBIE NFKBIB CHUK PPIA IKBKB IKBKG MALT1 BTRC RELA SKP1 NFATC2 NFATC1 CALM1 FBXW11 RASGRP3 NFKB1 NFATC3 UBA52 MAP3K7 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 CARD11 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 BCL10 PSMD3 FKBP1A RASGRP1 PSMB1 PSMD1 HRAS PRKCB ADRM1 PPP3R1 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PTPMT1 PLD4 PLD6 PLD1 PLD3 CDS2 PLD2 PGS1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2C9 CYP2C8 CYP2D6 CYP1A2 CYP2E1 CYP3A4 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY MAT1A MAT2B CYP1A2 MTR AS3MT MAT2A TPMT TRMT112 HEMK2 MTRR COMT GSTO1 NNMT ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation BRAF CRK KIDINS220 NTRK1 YWHAB RAP1A NGF EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A CDK4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion GNA14 FFAR1 GNA15 PLCB3 GNA11 PLCB1 PLCB2 ACSL4 ACSL3 GNAQ CD36 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein ST3GAL1 MGAT5 ST3GAL2 ST3GAL3 OST4 EDEM2 MGAT1 OSTC STT3A MGAT2 STT3B ZDHHC5 ZDHHC8 ST6GALNAC2 ZDHHC2 ZDHHC3 ZDHHC9 PRKCSH TUSC3 DDOST MAGT1 DAD1 MAN1B1 GOLGA7 ST6GALNAC3 ST6GALNAC4 GANAB ST6GAL1 TMEM258 MOGS ZDHHC11 MGAT4C MGAT4A MGAT4B RPN2 CANX RPN1 FUT8 ZDHHC20 MAN2A1 ST3GAL4 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation ACOT2 MT-CO2 HSD17B10 SHMT2 MRPL12 DBT NDUFA2 TRIAP1 MT-ATP6 ATP5F1A GLUD1 ATP5F1B ALDH1B1 OGDH ATP5F1C MT-ND6 MT-ND5 MT-ND2 MT-ND1 COX5B COX5A LONP1 PRKACA HSPA9 UQCRC2 HMGCS2 IDH3A TFAM ALDH2 PDHB TWNK SSBP1 CS ACAD8 FECH PDHA1 ARG2 PDK1 BDH1 DLD FH SUCLG2 PCCB NDUFV3 UQCRQ OXCT1 NDUFV1 MDH2 ACO2 ALAS1 PRELID1 SLC25A5 STARD7 SLC25A6 CHCHD2 ATP5PF OXSM ECH1 NDUFS3 ATP5PD CLPX CLPP ACAT1 LDHD ALDH18A1 NDUFS1 OPA1 TIMM17A TIMM22 TIMM9 SPG7 TIMM10 AFG3L2 SMDT1 YME1L1 PMPCA MRPS10 ATP5PO NDUFA13 MICU2 MRPL32 COX4I1 HADH ECI1 NADK2 ME2 IARS2 ATP5MG MT-CO1 MRPS2 OMA1 ACADSB IDH2 STAR NDUFB6 HTRA2 HSPD1 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease STAT3 ERLIN2 BCR NRAS PIK3R1 FRS2 PIK3CA ZMYM2 GTF2F1 GTF2F2 GAB2 FGF6 CUX1 GAB1 PLCG1 FGFR4 FGF7 FGF22 STAT5A FGF3 STAT5B FGF10 FGFR1OP2 LRRFIP1 NCBP1 STAT1 NCBP2 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 CPSF6 TRIM24 FGF2 FGFR3 FGFR2 FGFR1 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F POLR2H BAG4 POLR2K POLR2L HRAS CEP43 MYO18A DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU FMO3 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRF3 TRAF3 LRRC14 TRAF6 USP14 IRF7 NLRC5 USP18 TIFA S100B SAA1 NOD1 NOD2 PTPN11 PPP2R1A BTRC UBE2D1 RELA SKP1 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD UBA52 TLR4 UBE2D2 TBK1 OPTN CUL1 UBB UBC RPS27A UBE2D3 DUSP4 DUSP3 RIPK3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 CHUK IKBKE IKBKB TP53 IKBKG RIPK2 MAPKAPK2 PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 MAPK3 MAP3K7 BIRC2 BIRC3 UBE2V1 TANK MAP2K6 IRAK1 IRAK2 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer PIK3CA MAPK3 PIK3R2 PIK3CB PIK3R1 CLIP1 MAPK1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 CCT6B TUBB6 TUBA4A TUBB3 TUBA3D TUBB1 TUBA3C CCT8 CCT7 CCT5 CCT4 CCT6A TUBA1A TUBB4B TUBB4A TUBA1C ACTB CCT3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 GNAT3 GNG10 GNAI3 GNG12 GNG11 GNG13 P2RY12 GNB2 GNAI1 GNAI2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells EGF AREG TGFA GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling EGF NRAS ERBB2 EGFR NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF SOS1 HRAS IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) MYD88 TLR10 IRAK4 TLR5 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation CAPZB DYNC1LI1 DYNC1LI2 KIF23 KIF22 KIF2A KIF2C KIF2B DYNC1I1 CENPE KIF26A LGMN CAPZA1 SEC23A CAPZA2 DYNLL2 SEC24B SEC24A ACTR1A SEC31A AP1G1 SEC24D AP1S2 SEC24C AP1S1 AP1S3 AP1B1 RAB7A CTSA SEC13 AP1M2 DYNLL1 AP1M1 DCTN1 DYNC1I2 DCTN2 DCTN3 ARF1 HLA-DQA2 DYNC1H1 HLA-DQA1 HLA-DPA1 SAR1B HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DQB2 HLA-DRB1 HLA-DQB1 LAG3 CD74 OSBPL1A CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 CANX CTSV CTSS CTSL CTSK KIF5C KIF5B KIF5A CTSD CTSB KIFAP3 KIF20A IFI30 KLC1 SPTBN2 KLC4 KLC3 KLC2 KIF3A CTSO KIF3B ACTR1B RACGAP1 CTSH CTSF KIF3C CTSE CTSC HLA-DMA HLA-DMB KIF18A CAPZA3 ACTR10 HLA-DOA KIF4B HLA-DOB KIF4A DCTN6 DCTN5 KIF11 DCTN4 KIF15 RILP SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4P1 PIP4K2B PIP4K2C FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins ADAR ADARB1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor GNG10 GNG12 GNAS GNG11 PTGIR GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle VAV2 BCR ARHGEF9 PIK3R2 DAAM1 WDR81 PIK3R1 CAV1 ARHGEF4 NGEF IQGAP2 IQGAP3 ARHGEF7 ARHGEF5 ABR ARHGEF6 WAS STARD13 JUP PAK1 CDC42 PLEKHG4B CDC42SE2 ARHGAP9 PAK6 PAK3 PAK5 ARHGAP1 PAK4 GIT2 ARHGAP4 MYO9B GMIP DLC1 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 ARHGDIG ARHGAP39 FGD1 FGD2 ARHGAP44 FGD3 SYDE1 ARHGAP42 FGD4 ARHGAP40 ARHGDIA CHN1 ARHGDIB LBR YKT6 RALBP1 RAB7A FARP1 KCTD3 ARHGAP45 MCF2 IQGAP1 DEF6 ARHGEF26 ARHGEF25 PAK2 ARHGAP17 SHKBP1 ARHGAP22 WASL ARHGAP20 ECT2 ARHGAP29 ARHGAP27 FAM13B ARHGAP26 ARHGAP24 ARHGAP33 ARHGAP32 GOLGA8R ARHGAP31 DNMBP ARHGAP30 DIAPH3 MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF19 ARAP2 ARAP3 ARHGAP10 SRGAP3 SRGAP2 SRGAP1 GNA13 MAP3K11 STOM ARHGAP11B RASGRF2 SNAP23 TAGAP FMNL3 FMNL1 FMNL2 PLEKHG3 DOCK7 PLEKHG4 PLEKHG1 PLEKHG2 ARFGAP3 ARFGAP2 PARD6A TIAM1 ARHGAP5 ARHGAP21 CDC42BPB CDC42BPA ARHGAP35 BAIAP2 DOCK10 DOCK11 SCRIB CPNE8 ARAP1 PLD1 KTN1 OPHN1 TMPO VANGL1 DEPDC1B SPATA13 RACGAP1 LAMTOR1 STEAP3 TRIO TFRC WIPF1 WIPF2 SH3PXD2A ITSN1 WIPF3 DOCK6 FNBP1L PREX2 DOCK9 GIT1 PREX1 DOCK8 WDR91 VAV3 FNBP1 STARD8 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants SHC1 CDC37 ERBIN EGF NRAS ERBB2 PLCG1 EGFR NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF SOS1 HRAS HSP90AA1 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction NOS1 SCN11A NPPA SCN10A SCN1B SCN1A AHCYL1 CACNG7 KCNK5 KCNK10 KCNK12 KCNK13 SCN3B NKX2-5 KCNJ14 KCNK15 SCN3A KCNK16 SCN2A KCNK17 KCNK18 SCN2B PRKACA SLC8A3 KCNK2 ATP2B4 KCNK4 ATP2A3 ATP2A2 ATP2B3 ATP2A1 ATP2B2 TRPC1 ATP2B1 SCN9A SRI CALM1 SLC8A1 KCND1 SLC8A2 KCNIP1 KCND2 KCNIP2 SCN8A KCND3 KCNIP4 SCN5A AKAP9 KAT2B SCN4A SCN4B STIM1 SCN7A MME ORAI2 NPR1 ORAI1 NPR2 NPPC CORIN CACNB2 CACNA1C ITPR1 ITPR2 ITPR3 KCNK9 KCNK3 SLN KCNJ2 KCNJ4 ATP1B3 ATP1B2 ATP1B1 KCNJ12 KCNQ1 KCNJ11 DMPK ABCC9 KCNA5 CACNG8 KCNH2 CACNB1 CACNG4 FXYD4 KCNIP3 KCNE1 FXYD3 KCNE2 KCNE3 FXYD2 KCNE4 KCNE5 FXYD1 FXYD7 FXYD6 FGF14 RYR1 FGF13 RYR2 FGF12 FGF11 RYR3 CLIC2 TBX5 TRDN ASPH CACNG6 TNNI3 RANGRF ATP1A4 ATP1A3 GATA4 ATP1A2 HIPK1 ATP1A1 HIPK2 PLN KCNK6 KCNK7 KCNK1 CES1 FKBP1B CAMK2B CAMK2D WWTR1 CAMK2A CACNA2D2 CAMK2G CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence H2AC14 CABIN1 H2BC12L RPS6KA3 CXCL8 RPS6KA2 RPS6KA1 ASF1A MAP2K3 MAP2K4 ACD TINF2 MAPKAPK3 MAPK9 TERF1 MAPK8 MAP2K7 TERF2 MDM2 POT1 MAPK10 TERF2IP UBN1 MDM4 CDKN2D ID1 CDKN2C TNRC6C MOV10 ERF AGO3 TNIK AGO4 AGO1 IGFBP7 TNRC6A TNRC6B H4C9 H2AC20 IL1A EZH2 HMGA1 H2AX CEBPB MAP4K4 ANAPC15 ANAPC16 UBE2D1 ANAPC10 RELA RAD50 ANAPC11 FZR1 CDC23 CDC26 CDC27 VENTX H3-3B ANAPC7 UBE2C H3C8 CDKN2A UBE2E1 NFKB1 IL6 UBE2S CDC16 LMNB1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 HIRA H2AJ UBA52 E2F2 CDKN2B CCNE2 CCNE1 H3C15 UBB SUZ12 UBC H2BC9 H2BC8 H2BC5 H2BC3 RPS27A H2BC1 H2AB1 STAT3 H2AC8 EP400 H2AC6 H2AC7 KAT5 TXN KDM6B SP1 CDK6 TP53 BMI1 ETS1 MAPKAPK2 RING1 TFDP1 TFDP2 RNF2 ATM CBX8 CDKN1A E2F1 PHC2 CBX6 E2F3 PHC1 MAPK14 JUN H2BC26 MAPK11 CBX4 CBX2 H2BC21 PHC3 MAPK7 CDKN1B H1-1 FOS H1-0 EED H1-3 H1-2 IFNB1 H1-5 H2BC17 H1-4 MAPK1 H2BC12 H2BC13 H2BC14 MAPK3 H2BC15 H2BC11 MAP3K5 CDK4 CDK2 CCNA2 MRE11 CCNA1 H3-4 NBN RBBP4 MINK1 MAPKAPK5 RB1 RBBP7 ETS2 EHMT2 H2AC19 EHMT1 MAP2K6 HMGA2 H2AZ2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 CHEK1 RAD9B RAD9A RPA1 HUS1 RPA2 EXO1 DNA2 RPA3 RHNO1 TOPBP1 RAD1 RFC5 RFC3 RFC4 RFC2 MRE11 ATRIP NBN BARD1 BRCA2 RAD51AP1 BRIP1 RAD17 RBBP8 ATM ATR BLM XRCC2 XRCC3 PALB2 RAD50 BRCA1 RAD51 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PIK3C3 PI4KB SACM1L PIKFYVE INPP5E PI4K2A ARF3 ARF1 OCRL TPTE2 TPTE FIG4 PI4K2B VAC14 PIK3R4 PIK3C2G PIK3C2A PI4KA DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE MTRR MTR MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins VPS28 TSG101 UBB MVB12B UBC MVB12A RPS27A VPS37C VPS37D VPS37A VPS37B UBA52 UBAP1 NMT2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDKN2A CDK4 CDK6 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSENEN PSEN2 YBX1 NOTCH3 APH1A APH1B PSEN1 NCSTN TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript ELOA ERCC3 NELFB ELOB NELFCD NELFA ELOC ERCC2 NELFE NCBP1 NCBP2 CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E GTF2H5 POLR2F ELOA2 POLR2H SUPT5H CDK9 CCNH SSRP1 POLR2K POLR2L TCEA1 ELL ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers H2AC14 H2BC12L DPF1 DPF2 DPF3 SMARCC1 SMARCC2 TCF4 SUPT16H TCF3 CREBBP NQO1 MYOG H4C9 SS18L1 MYOD1 SMARCA2 SMARCA4 CTR9 RTF1 H2AC20 PAF1 H2AX PWWP2B DHX15 ZMYND8 CHD5 IKZF1 MBD3L2 IKZF2 PHF6 IKZF3 MBD3L1 ADNP2 PWWP2A ZNF687 H3-3B TCF19 ADNP ZNF592 ZNF827 H3C8 CBX1 SS18 NR2F2 TCF12 CDK2AP2 DDX46 CDK2AP1 ZNF532 DDX42 ACTL6A RBM17 H2AJ SMNDC1 U2SURP SNRPD2 DKK2 PBRM1 SNRPD1 ACTL6B SNRPD3 SNRPA1 CHD8 H3C15 CHD7 CHD6 SF3B1 CTCF NKD2 MBD3 FAM124B IGF2 SF3B4 H2BC9 SF3B5 H2BC8 SF3B2 H2BC5 SF3B3 SF3B6 H2BC3 MBD2 SF3A3 H2BC1 SF3A1 SF3A2 GATAD2B GATAD2A ARID2 SSRP1 H2AB1 CHERP EP300 H2AC8 H2AC6 PUF60 H2AC7 UBE2I SNRPB2 CTNNB1 BCL11A FBP1 G6PC1 SUMO1 CHD2 PHF5A SNRPN CBX3 MAFK NFE2L2 CHD9 SKIC8 CHD4 CHD3 H2BC26 BCL7A H2BC21 BCL7C BCL7B BICRAL WDR5 BICRA BRD9 PHF10 BCL11B ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 BRD7 H2BC11 CDC73 SMARCD1 AXIN2 HDAC2 SMARCD2 SMARCD3 HDAC1 LEO1 SNRPG MTA1 RBBP4 SNRPE SNRPF SMARCB1 SNRPB PCK1 RBBP7 NR2C2 MTA2 MTA3 H2AC19 SMARCE1 ACTB H2AZ2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK TSC2 TSC1 PRKAA2 CAB39L RHEB STRADA STRADB PRKAB1 RRAGA RRAGC RRAGB RRAGD MLST8 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKAG2 PRKAA1 STK11 CAB39 PRKAB2 MTOR SLC38A9 PRKAG1 PPM1A PRKAG3 RPTOR VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs H2AC14 PSMA5 SEM1 H2BC12L PSMA6 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SPI1 KMT2A TCF3 LDB1 ABL1 CBFB H4C9 RUNX1 CDK7 H2AC20 MNAT1 H2AX TP73 H2BC26 H2BC21 MYB H3-3B H3C8 TCF12 TAL1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ UBA52 H2BC11 GATA3 GATA2 GATA1 LMO1 LMO2 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC H2BC9 H2BC8 ITCH H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 CCNH PSMD3 PSMB1 H2AC19 PSMD1 YAP1 H2AB1 H2AZ2 ADRM1 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage UPP2 GMPR UPP1 APRT ADA ADK AMPD1 UCK2 HPRT1 UCK1 AMPD2 AMPD3 TK2 TK1 DCK TYMP GMPR2 CDA UCKL1 PUDP PNP DGUOK MAPDA TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI RFC5 RFC3 UBB RFC4 RFC2 UBC RFC1 RPS27A PCNA POLI UBA52 RPA1 RPA2 REV1 MAD2L2 RPA3 REV3L AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus AKT1 FOXO6 FOXO4 FOXO3 FOXO1 NR4A1 AKT2 RPS6KB2 AKT3 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling CALM1 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 KPNA2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A AHCYL1 PRKCD PRKAR2B PRKCA PLCG1 PRKCE CAMKK1 CAMKK2 NBEA ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D PRKX CAMK2A PRKACA PRKCG PDE1C CAMK2G GRK2 PDE1B PDE1A LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis SCD RXRA FASN NR1H3 NRIP1 ANGPTL3 RXRB NR1H2 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis FDX2 STAR STARD3 STARD4 STARD3NL STARD6 CYP11A1 FDXR TSPO AKR1B1 FDX1 TSPOAP1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway PSMA5 SEM1 PSMA6 PSMA3 PSME1 PSMC5 PSMA4 PSMC6 SEC61A2 PSMC3 SEC61A1 PSMA1 SEC61G PSMA2 SEC61B PSMC4 SEC22B PSMC1 PSMB10 PSMC2 PSMB8 PSMB9 S100A1 MYD88 HMGB1 CHUK SNAP23 FGB FGA FGG IKBKB PDIA3 IKBKG TAP2 TAP1 TIRAP TAPBP TLR1 S100A9 S100A8 VAMP3 TLR2 STX4 VAMP8 CD36 TLR6 LY96 BTK CD14 TLR4 UBA52 PSME2 B2M PSMD12 PSMD11 UBB PSMD14 PSMD13 HLA-H UBC HLA-B CALR HLA-C PSMA7 HLA-A PSMB6 RPS27A PSMD8 HLA-F HLA-G PSMB7 HLA-E PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes DDIT3 NFYA NFYB ATF4 HSP90B1 NFYC ATF6 HSPA5 CALR FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling PIK3R2 PIK3CB PIK3R1 MS4A2 MAP2K4 TEC MAPK9 MAPK8 PLCG2 MAP2K7 MAPK10 PIK3CA PLCG1 TXK BTRC UBE2D1 RELA SKP1 FBXW11 NFKB1 PAK2 NFATC3 UBA52 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 CUL1 IGHV3-30 V3-4 V3-3 PSMD12 V2-17 PSMD11 UBB V3-2 IGHV3-33 PSMD14 V2-15 PSMD13 IGKV1D-39 UBC V2-19 ITK IGKV1D-33 CDC34 PSMA7 IGKV2D-28 IGKV4-1 PSMB6 RPS27A PSMD8 IGHV7-81 PRKCQ PSMB7 CARD11 ITPR1 V1-11 PSMB4 ITPR2 PSMD6 IGKV2D-30 V1-16 PSMB5 PSMD7 V1-13 ITPR3 PSMB2 IGHV4-59 IGHV1-69 PSMB3 PSMD2 BCL10 PSMD3 RASGRP2 PSMB1 RASGRP1 PSMD1 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 ADRM1 IGLV2-14 PSMA5 IGLV1-44 IGKV3-15 SEM1 PSMA6 IGKV3-11 LYN PSMA3 PSMC5 V2-8 V1-20 PSMA4 IGKV2D-40 PSMC6 IGHV3-11 IGHV3-13 PSMC3 PSMA1 IGKV1D-16 PSMA2 IGLV7-43 PSMC4 IGKV1D-12 PSMC1 NFKBIA PSMC2 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 MALT1 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 FOS MAPK1 MAPK3 BTK SOS1 MAP3K7 LAT2 UBE2V1 VAV3 HRAS VAV1 VAV2 SYK NRAS FYN UBE2N TAB3 TAB2 TAB1 PAK1 PDPK1 GAB2 TRAF6 AHCYL1 MAP3K1 CALM1 GRAP2 LCP2 PPP3R1 PPP3CA PPP3CB CHUK IKBKB IKBKG JUN NFATC2 NFATC1 RAC1 FCER1A FCER1G TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 S100A1 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 FGB FGA PELI1 LRRC14 FGG TRAF6 USP14 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 TLR1 PPP2R1A S100A9 S100A8 TLR2 BTRC RELA SKP1 CD36 FBXW11 NFKB1 LY96 TRAF2 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT SOCS1 DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 SIGIRR IRAK3 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TIRAP PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 TLR6 FOS MAP2K1 MAPK1 MAPK3 BTK MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism DSEL IDUA HEXB NCAN HEXA CHPF2 BGN GLB1L3 GLB1L2 CHST11 CHST12 VCAN CHST15 GLB1L HYAL1 GLB1 HYAL3 HYAL4 CHST13 IDS CHST14 CHST3 CSPG5 GUSB DCN UST ARSB CSGALNACT1 CSGALNACT2 CHPF DSE CHSY1 BCAN CHSY3 CHST7 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic RAB30 CAPZB RAB36 KIF13B GOSR2 DYNC1LI1 ALPP AGPAT3 DYNC1LI2 KIF1C KIF1B KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIFC2 KIF2A KIFC1 KIF2C KIF2B DYNC1I1 CENPE KDELR1 KIF26A CAPZA1 GCC2 KIF26B CAPZA2 DYNLL2 RAB9A GALNT1 ACTR1A RAB9B M6PR VAMP3 VPS45 COPB1 VAMP4 NAPA STX5 YKT6 TGOLN2 DYNLL1 DCTN1 IGF2R PAFAH1B1 DYNC1I2 DCTN2 DCTN3 SURF4 ARF3 ARF1 DYNC1H1 MAN1A2 MAN1C1 MAN1A1 BICD1 RHOBTB3 BICD2 GALNT2 PAFAH1B3 PAFAH1B2 GOLGA4 SEC22B NSF CUX1 ARFGAP3 TRIP11 ARFGAP2 TMED2 RAB6B COG1 RAB6A RAB39A KIF28P SNAP29 ARF4 KIF5C KIF5B PLA2G6 KIF5A KIF21A KIF21B USP6NL KIFAP3 SCOC SYS1 KIF16B GCC1 ZW10 KIF20A RAB43 KIF20B GOLGA1 ARFIP2 RINT1 KDELR2 RAB33B COPB2 COPA ARL1 KLC1 COPE USE1 RABEPK ARFGAP1 KLC4 TMED3 KLC3 TMED7 KLC2 KIF3A TMED9 RAB1A KIF3B NAA30 RACGAP1 COPZ2 RAB1B COPZ1 KIF3C NAA35 NAA38 ARF5 NBAS TMF1 STX18 STX10 RIC1 KDELR3 KIF18A ARFRP1 CAPZA3 VPS51 GBF1 ACTR10 KIF18B STX16 VPS53 RGP1 KIF4B GOSR1 VPS52 GOLIM4 KIF4A BNIP1 CYTH3 VPS54 PLA2G4A CYTH2 ARCN1 RAB18 RAB41 RAB3GAP2 COPG2 GOLGA5 COPG1 RAB3GAP1 PLIN3 CYTH4 STX6 VTI1A NAPB TMED10 CYTH1 COG8 COG7 DCTN6 COG6 MAN2A2 KIF12 DCTN5 COG5 KIF11 DCTN4 NAPG COG4 COG3 KIF15 COG2 MAN2A1 KIF19 BET1L PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease RPIA TALDO1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF STAT3 PIK3R2 PIK3CB NRAS PIK3R1 PTPN12 PIK3CA PDGFB PDGFRA COL4A5 NCK2 NCK1 PDGFRB PLCG1 PTPN11 SRC COL9A1 STAT6 COL9A3 STAT5A COL9A2 STAT5B STAT1 RAPGEF1 COL4A2 CRKL COL4A1 COL4A4 THBS2 COL6A2 COL4A3 COL6A1 CRK COL6A3 GRB7 SOS1 COL6A6 COL6A5 PLG FURIN BCAR1 SPP1 PLAT THBS4 THBS3 PDGFD THBS1 HRAS RASA1 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle SNAP25 VAMP2 TSPOAP1 UNC13B RAB3A SYT1 STX1A SYN3 SYN2 CPLX1 SYN1 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding APC PPP2R1B PPP2R5E CSNK1A1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling CSF3R IFNL1 JAK1 IL32 SNAP25 CASP3 IL34 VAMP2 PTPRZ1 TYK2 SDC1 STXBP2 IL16 PRTN3 CSF1R IL10RB STX1A CSF3 CSF1 IFNLR1 TXLNA STX4 CD4 STX3 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation CALM1 RPS2 ETFB EEF1A1 EEF2 METTL21A VCP CAMKMT KIN HSPA8 METTL22 EEF2KMT ETFBKMT VCPKMT EEF1AKMT2 PRMT3 EEF1AKMT1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway ADCY9 ADCY4 ADCY3 GNAL ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT1 APC PPP2R1B FZD1 PPP2R5E DVL1 DVL2 FZD2 FZD5 DVL3 CAV1 CTNNB1 LRP5 LRP6 CSNK1G2 CSNK1A1 WNT8A WNT8B PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A WNT3A PPP2R5D PPP2R5C PPP2CA PPP2CB FRAT1 FRAT2 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis GNPAT AGPS DHRS7B PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling PDE3B AKT2 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism LCAT APOBR NR1H3 ALB MYLIP NR1H2 PCSK9 LSR LIPA NCEH1 NPC1 AMN SOAT1 NPC2 SOAT2 LPL HDLBP CLTC CLTA AP2A1 AP2B1 LDLRAP1 AP2A2 A2M PCSK6 AP2S1 PRKACA VLDLR CETP ABCG1 PCSK5 LMF2 PRKACG LMF1 LIPC PRKACB ANGPTL8 ANGPTL3 FGF21 APOA2 APOF APOA1 LPA MBTPS1 APOA4 ZDHHC8 APOA5 MBTPS2 UBA52 GPIHBP1 ANGPTL4 ABCA1 APOC1 MTTP APOC4 P4HB APOB UBB FURIN APOC3 UBC CES3 CREB3L3 RPS27A APOC2 CUBN APOE SAR1B LDLR LIPG ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN SRC DOCK3 NTRK2 RAC1 BDNF GRIN2B RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE ERCC3 ERCC2 GTF2F1 GTF2F2 RNMT RAMAC POLR2A POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 RNGTT GTF2H4 POLR2E GTF2H5 POLR2F POLR2H SUPT5H CCNH POLR2K POLR2L RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing RPL24 RPL27 RPL26 RPL29 RPL28 TRMT10C PRORP ELAC2 RPL41 RPL3L RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 CSNK1D RPL17 RPL19 CSNK1E TFB1M RPS15 RPS14 EXOSC10 RPS17 UBA52 LTV1 RPS16 C1D RRP1 RPS19 MPHOSPH6 FTSJ3 EBNA1BP2 RPS18 ISG20L2 ERI1 LAS1L NOL12 RBM28 RPS11 RIOK2 RIOK1 TEX10 RPS10 SENP3 RPS13 GNL3 NIP7 RPS12 NOL9 PES1 RIOK3 WDR18 WDR12 RPLP1 BYSL RPLP0 BOP1 RPS27A TSR1 TRMT112 RPS4Y2 RPLP2 NCL RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A DIS3 RPL35A RPL22L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS27L RPS15A RPS3 RPS2 FAU RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL39L MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 HSD17B10 RCC1L NGRN MRM1 MRM2 MRM3 MTERF3 RPL10L RPL10A RPS4X RPS3A RPL23A FASTKD2 SNU13 RPL27A RPL13A XRN2 RPL18A RPL36AL MTREX NOP58 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C NOP56 UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 GAR1 DHX37 RRP36 UTP20 DCAF13 UTP6 NOP14 UTP4 UTP3 PNO1 KRR1 RCL1 TBL3 MPHOSPH10 NOL11 NOP10 PELP1 RPP30 RPP38 RPP21 RPP25 RPL26L1 RPL4 RPL5 RPP14 RPL30 RPL3 RPL32 RPP40 RPL31 RPL34 RPL9P9 RPL8 RPL6 NOP2 RPL7 RPL36 RPL35 DDX21 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system H2AC14 H2BC21 H3-3B H2BC12L H2AZ1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PRCP H4C9 H3C15 SERPING1 H2BC9 H2BC8 KNG1 H2BC5 H2BC3 F12 H2AC20 KRT1 H2BC1 A2M C1QBP H2AX PLAUR KLKB1 HRG H2AC19 H2BC26 H2AB1 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F2 PROC BGLAP F7 PROS1 F9 GAS6 PROZ F10 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism CYP24A1 LRP2 CUBN LGMN PIAS4 SUMO2 UBE2I GC VDR CYP27B1 CYP2R1 LDLRAP1 AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy CETN1 DYNC1LI1 DYNC1LI2 UBB UBC PRKN UBE2N DYNLL2 PCNT DYNLL1 RPS27A IFT88 UBE2V1 HDAC6 DYNC1H1 HSF1 UBA52 CFTR PARK7 VCP ARL13B DYNC1I2 HSP90AA1 DYNC1I1 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections HMG20B JAK2 SIGMAR1 PCBP2 TLR1 TLR2 ZBP1 RIPK1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 BRD4 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 RCAN3 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 RIPK3 PSMC6 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 NFKBIA IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 NMI IGHV1-46 SH3KBP1 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 YWHAB IGKV3D-20 AKT1 IGLV3-19 NUP214 HNRNPA1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 YWHAZ IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGHV3-53 S1PR1 IGLC7 IGKV5-2 IGKV1-5 IGLC6 KPNB1 ITGA4 RBX1 NPM1 SOS1 CSNK1A1 ITCH CUL3 NUP107 NUP188 NUP210 NUP93 CHMP4C CHMP4B CHMP4A NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 CHMP2B CHMP2A NUP62 NDC1 SEC13 NUP133 NUP50 CHMP3 NUP54 CHMP6 CHMP7 NUP42 NUP43 RAE1 RANBP2 ARID4A NUP35 BRMS1 NUP37 UBE2I NR3C1 SUMO1 CHUK SP1 ISG15 IFIH1 PPIA IKBKB REST TRIM25 IKBKG RIGI AP2A1 AP2B1 AP2A2 AP2S1 ROCK1 ITGB1 SMAD4 SMAD3 PLCG2 JAK3 PTPN6 RUNX1 YWHAE RELA YWHAG HSP90AA1 TUBB NFKB1 FKBP4 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 UBA52 RPS17 RPS16 TBK1 RPS19 SNRPD2 RPS18 SNRPD1 AKT2 AKT3 SNRPD3 RPS11 B2M GOLGA7 RPS10 RPS13 UBB VPS39 RPS12 VPS18 HLA-H UBC ST6GAL1 HLA-B HLA-C MOGS RPS27A HLA-A ATG14 HLA-F HLA-G HLA-E ACE2 RPS4Y2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 RPS4Y1 IFIT1 LARP1 IFIT3 VPS11 IFIT2 ST3GAL4 SFN ST3GAL1 ST3GAL2 VPS16 ST3GAL3 SRPK2 EDEM2 BCL2L1 PARP16 PARP14 SRPK1 PARP10 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 ATP1B3 RPS23 IFNA5 ATP1B2 NRP1 ATP1B1 IFNA4 IFNA7 IFNGR1 IFNA6 IFNGR2 IFNA1 IFNA2 MAGT1 IFNA8 MAP1LC3B HSPG2 TRIM4 HAVCR1 IKBKE NCK1 JAK1 TOMM70 PARP6 PARP4 PRMT1 RIPK2 SFTPD ANO8 ANO9 ANO6 TYK2 ANO7 IMPDH1 ZDHHC11 IMPDH2 ANO4 PARP9 ANO5 IL17RC ROCK2 ANO2 PARP8 ANO3 IL17RA ANO1 SIKE1 CANX TLR8 TLR7 FXYD4 ZDHHC20 RPS27L FXYD3 TMPRSS2 RNF135 FXYD2 RPS15A GPC1 FXYD1 MGAT5 FXYD7 RPS3 CTSL FXYD6 GPC3 ANO10 GPC2 GPC5 MGAT1 RPS2 GPC4 MGAT2 GPC6 STAT1 IFNB1 STAT2 TJP1 NLRP12 STING1 ZDHHC9 IL17F BTK FAU AGRN CRB3 IL17A ATP1A4 TUSC3 ATP1A3 GEMIN2 KPNA2 ATP1A2 MAP3K7 RPS9 ATP1A1 IFNA14 RPS7 RPS8 PPIB IFNA16 RPS5 VPS33A IFNA17 RPS6 VPS33B FURIN RPSA ZCRB1 TUFM TMEM258 GEMIN4 SNRPG GEMIN5 GEMIN6 SNRPE UBE2V1 GEMIN7 MASP1 SNRPF GEMIN8 ISCU IFNA10 RB1 IFNAR1 SNRPB FKBP1A VCP DDX5 FUT8 TKFC CYSLTR1 IRAK1 IRAK2 MAN2A1 G3BP1 VAV1 SMN2 G3BP2 NLRP3 IFNA21 UVRAG SYK OST4 CAV1 MAVS OSTC STT3A UBE2N TAB3 TAB2 TAB1 STT3B PALS1 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH RPS4X YWHAQ MBL2 YWHAH PDPK1 RPS3A DDOST TLR9 IRF3 DAD1 TRAF3 CREBBP TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB VHL SEC24B SEC24A CNBP GALNT1 PTPN11 MGAT4C MGAT4A MGAT4B VPS41 VPS45 SEC24D SEC24C CRBN FNTA FNTB PDCD1 MBD3 BST2 IGHM IGHD GATAD2B GATAD2A IL6R PPIH PPIG ARID4B EP300 SAP30 PYCARD CASP1 SUDS3 NFE2L2 EEF1A1 GSK3B NPIPB3 CHD4 IL1R1 CHD3 KEAP1 CD79B CD79A PTGES3 KDM1A COMT PHF21A HDAC2 BLNK HDAC1 MTA1 RBBP4 SAP30L RCOR1 SAP18 RBBP7 MTA2 MTA3 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors ING2 EP300 MRTFA TRIM28 NCOA1 PHC3 ZNF131 NCOA2 PIAS4 PIAS3 SAFB UBE2I UHRF2 CASP8AP2 CTBP1 ZNF350 MBD1 PIAS1 NCOR2 SUMO1 DAXX NPM1 SUMO3 SUMO2 NRIP1 PPARGC1A HIPK2 CREBBP PCGF2 BMI1 RING1 RNF2 TOPORS PARK7 CBX8 DDX17 DDX5 PHC2 PHC1 CBX4 CBX2 SIN3A SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions SIRPG PTPN6 PTK2B PTK2 SIRPA FYB1 TYROBP SKAP2 CD47 SIRPB1 PTPN11 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PAN2 CNOT10 PAN3 CNOT4 EIF4A3 SKIC2 CNOT6 CNOT7 CNOT1 CNOT11 HBS1L NT5C3B CNOT2 SKIC3 CNOT3 DCPS CNOT8 CNOT9 DIS3 XRN1 PABPC1 SKIC8 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 EIF4A2 DCP1A EIF4A1 EIF4G1 TUT7 TUT4 TNKS1BP1 CNOT6L EIF4E EIF4B PAIP1 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2R1B PPP2R1A MLXIPL PPP2R5D PPP2CA PFKFB1 PPP2CB DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 TBP GTF2B GTF2A1 GTF2F1 GTF2A2 GTF2F2 TAF9 TAF1L POLR2A POLR2B POLR2C GTF2E1 POLR2D GTF2E2 CDK7 POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH TAF8 POLR2K POLR2L TAF4B TAF7 TAF6 TAF7L TAF5 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins ETV6 NOX4 SPTBN1 NRAS PIK3R1 TRIP11 PIM1 PIK3CA ZMYM2 STAT5A CDKN1A STAT5B GOLGB1 SOS1 HRAS GAB2 MYO18A POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2AC14 EP300 H2BC12L H2AC8 H2AC6 ERCC6 H2AC7 H4C9 CBX3 SMARCA5 H2AC20 H2AX GSK3B CHD4 CHD3 H2BC26 H2BC21 H3-3B H3C8 TBP BAZ1B H2BC17 H2BC12 H2BC13 H2BC14 KAT2B H2BC15 KAT2A H2AJ POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 H3C15 SF3B1 MBD3 HDAC1 H2BC9 DDX21 H2BC8 TAF1D H2BC5 MTA1 TAF1B H2BC3 RBBP4 TAF1C H2BC1 TAF1A POLR2E POLR2F GATAD2B GATAD2A POLR2H RBBP7 MTA2 MYBBP1A EHMT2 MTA3 H2AC19 POLR2K POLR2L H2AB1 ACTB H2AZ2 TTF1 DEK GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) GYG1 GYS1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits KCNJ2 KCNJ3 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 GNG4 KCNJ10 GNG7 GNG8 KCNJ12 KCNJ9 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock CRTC1 CIPC TFEB PER2 PER1 CLOCK RBM4 PER3 MED1 DBP BHLHE40 MEF2C CRY2 CRY1 SIK1 BHLHE41 KLF15 NOCT BMAL2 PPP1CC PPARGC1A CREBBP SREBF1 SERPINE1 F7 BMAL1 PPP1CB BTRC UBE2D1 CRTC2 CRTC3 SKP1 RAI1 MEF2D NCOA1 FBXW11 NCOA2 NCOA6 CSNK1D CSNK1E SIRT1 UBA52 NCOR1 NRIP1 FBXL21P CUL1 PSMD12 TBL1X PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 RORC RORB PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 FBXL3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PPP1CA ADRM1 EP300 PSMA5 SEM1 CPT1A PSMA6 PSMA3 PSMC5 PSMA4 NPAS2 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 RORA PSMC1 PSMC2 ATF2 TBL1XR1 KMT2A HELZ2 RXRA PPARA AVP TGS1 CHD9 CDK5 CARM1 CSNK2A1 CSNK2A2 NAMPT CSNK2B RBX1 NR1D1 HDAC3 SMARCD3 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis AKR1B1 SORD DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 CYP11B1 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors GNAT3 GNAI3 KCNJ2 KCNJ3 ADCY9 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 ADCY4 GNG4 KCNJ10 GNG7 ADCY3 ADCY2 GNG8 KCNJ12 ADCY1 KCNJ9 ADCY8 ADCY7 ADCY6 KCNJ15 ADCY5 KCNJ16 GNG10 GNG12 GNAL GNG11 GNG13 GNB2 GNAI1 GNAI2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation CALM1 PDE1C PDE1B PDE1A REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor CITED2 EP300 EPO ARNT VEGFA HIF1A CA9 HIGD1A EPAS1 CREBBP C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen FGB FGA FGG PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation ING2 EP300 PIN1 TP53 PIP4K2A PIP4P1 PIP4K2B MAP2K6 PIP4K2C BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways DUSP16 SV2C SV2B VAMP1 SV2A CD9 VAMP2 MAP2K4 PGK1 CTNNB1 MAP2K7 GSK3A CDH1 HSP90AB1 SH3KBP1 KPNA1 EPCAM SNAP25 TRIM27 MET CTNND1 TXNRD1 GUCY2C CBLL1 EPS15 UPK1A CASP4 SRC EEF2 CALM3 NHERF4 CALM2 SH3GL2 STX1B STX1A TLR2 LTF HBA2 RAB5A KPNB1 SH3GL3 SH3GL1 HSP90AA1 CALM1 NOS2 CORO1A HGS ATP6V1H RAB7A CTSG MAP2K1 PDCD6IP MAP2K2 STAM2 MAPK1 SFPQ MAPK3 RNF213 UBA52 UBE2D2 HBEGF ENO1 CBL B2M UBB MRC1 VPS33B FURIN STAM UBC GBP2 GBP1 RPS27A GBP4 GBP6 SYT1 HBB SYT2 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 AXIN2 PSMD12 PSMD11 UBB PSMD14 TNKS PSMD13 TNKS2 SMURF2 UBC RNF146 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 AXIN1 PSMD3 PSMB1 PSMD1 ADRM1 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD GPC1 GPC3 GPC2 GPC5 NCAN GPC4 BGN GPC6 VCAN SDC1 SDC4 CSPG5 DCN AGRN SDC2 SDC3 B3GAT3 HSPG2 BCAN DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function RLBP1 RDH5 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance H2AC14 H2BC12L H2AC8 PIF1 H2AC6 SHQ1 PRIM2 H2AC7 PRIM1 ACD POLA1 TINF2 POLA2 ATRX RTEL1 TERF1 TERF2 POT1 TERF2IP DAXX LIG1 POLD1 DNA2 H4C9 RFC5 RFC3 RFC4 RFC2 DKC1 NHP2 H2AC20 H2AX GAR1 H2BC26 FEN1 DSCC1 CHTF18 H2BC21 H3-3B CHTF8 CTC1 STN1 NOP10 TEN1 H2BC17 PCNA WRN H2BC12 H2BC13 H2BC14 H2BC15 H2AJ RPA1 H2BC11 RPA2 RPA3 POLR2A POLR2B TERT POLR2C CDK2 CCNA2 POLR2D CCNA1 H2BC9 RFC1 H2BC8 POLR2G H2BC5 H3-4 POLR2I H2BC3 POLR2J H2BC1 PPP6C PPP6R3 POLR2E RUVBL2 POLR2F RUVBL1 BLM POLR2H WRAP53 H2AC19 POLR2K POLD3 POLR2L H2AB1 POLD4 POLD2 ANKRD28 H2AZ2 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling SYK CDKN1B NRAS PIK3R1 ABL2 HCK PTPRJ GRAP2 FYN PIK3CA FLT3LG GRB10 UBA52 FOXO3 SOS1 SH2B3 FLT3 AKT2 GAB2 CBL AKT3 AKT1 UBB UBC LCK RPS27A PTPN11 SOCS6 SLA2 SOCS2 STAT5A STAT5B CSK HRAS BCL2L11 SLA LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA BCKDHB DLD DBT DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 PROC F5 PROS1 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones DDIT3 NFYA NFYB MBTPS2 ATF4 HSP90B1 NFYC ATF6 HSPA5 CALR MBTPS1 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia EP300 PSMA5 SEM1 PSMA6 PSMA3 VEGFA PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 HIF1A CA9 PSMA2 PSMC4 PSMC1 PSMC2 HIF3A EPO HIF1AN CUL2 CREBBP VHL LIMD1 UBE2D1 ELOB ELOC RBX1 CITED2 EGLN1 EGLN3 EGLN2 UBA52 WTIP UBE2D2 AJUBA EPAS1 PSMD12 ARNT PSMD11 UBB PSMD14 PSMD13 UBC HIGD1A PSMA7 PSMB6 RPS27A UBE2D3 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 DHDDS NUS1 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A CUL2 ZNF598 ASCC2 ASCC3 UBE2D1 RPL10 RPL12 RPL11 ELOB RPL14 RPL13 ELOC RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 RPS17 UBA52 UBE2D2 RPS16 RPS19 RCHY1 RPS18 RPS11 RPS10 PSMD12 RPS13 PSMD11 UBB RPS12 PSMD14 PSMD13 UBC RPLP1 PSMA7 RPLP0 PSMB6 RPS27A UBE2D3 PSMD8 PSMB7 PSMB4 PSMD6 RPS4Y2 RPLP2 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 RPL18A PSMB1 RPL36AL PSMD1 RPS4Y1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 RPS26 PSMA2 RPS25 PSMC4 PELO RPS28 PSMC1 RPS27 PSMC2 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A RPL22L1 RPS27L RPS15A RPS3 ABCE1 RPS2 RBX1 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 ANKZF1 KLHDC10 RPL21 NPLOC4 VCP TCF25 RPL23 UFD1 RPL22 NEMF LTN1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function CDH8 JUP CTNND1 ADAM19 CDH11 CDH24 CTNNA1 ADAM33 CTNNB1 ANGPTL4 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling EIF4A3 JAK2 PIM1 KPNA7 KPNA4 KPNA5 KPNA3 IRF1 PTPN6 IRF2 PPM1B ILF2 IFITM3 PLCG1 IFITM2 IFIT5 ILF3 PPP2R1A EIF2AK2 SKP1 EIF2S3 OASL OAS1 OAS3 EIF2S2 EIF2S1 FLNA GBP3 GBP5 UBE2E1 GBP7 HSPA2 RPS15 RPS14 RNASEL RPS17 UBA52 FLNB RPS16 RPS19 RPS18 IFNG RPS11 CUL1 B2M PTPN2 RPS10 CENPS IFI35 RPS13 UBB RPS12 RSAD2 HLA-H UBC HLA-B HLA-C DNAJC3 HLA-A RPS27A HLA-F HLA-G HLA-E HLA-DQA2 RPS4Y2 HLA-DQA1 HSPA1B HLA-DPA1 HLA-DRB5 HLA-DRB4 MID1 IFIT1 RPS4Y1 HLA-DPB1 ISG20 CDK1 IFIT3 IFIT2 HLA-DRA HLA-DRB3 IRF6 SFN EIF4G3 IRF9 HLA-DQB2 STAT3 EIF4G2 EIF4E3 MX2 HLA-DRB1 MX1 HLA-DQB1 FCGR1BP RPS26 RPS25 RPS28 RPS27 RPS29 PSMB8 RPS20 RPS21 PTAFR RPS24 TRIM8 RPS23 TRIM6 IFNA5 TRIM5 TRIM2 IFNA4 TRIM3 IFNA7 IFNA6 IFNGR1 IFNA1 IFNGR2 IFNA2 IFNA8 RAF1 NCK1 JAK1 NUP214 ADAR PRKCD TYK2 EIF1AX XAF1 EIF3M EIF3K EIF4E2 EIF3L EIF3I EIF3J EIF3G PDE12 EIF3H EIF3E EIF3F EIF3C EIF3D HSPA8 EIF3A KPNB1 EIF3B RPS27L HSPA1A RPS15A EIF4G1 RPS3 ABCE1 RPS2 STAT1 IFNB1 STAT2 MAPK1 MAPK3 IFI30 FAU IFITM1 ICAM1 NPM1 KPNA2 RPS9 IFNA14 RPS7 CD44 RPS8 IFNA16 RPS5 IFNA17 RPS6 FURIN RPSA VCAM1 IFNA10 IFNAR1 IRF8 TARBP2 PRKRA MAP2K6 ACTB FANCC IFNA21 MAVS UBE2N FCGR1A NUP107 NUP188 PIN1 RPS4X KPNA1 NUP210 EGR1 RPS3A IRF3 NUP93 IRF7 NUP205 HSPA1L POM121 USP18 BECN1 AAAS NUP160 POM121C NUP85 TPR NUP88 PTPN11 NUP155 NUP153 ACTG1 PML EIF4A2 EIF4A1 NUP62 SNCA NDC1 SEC13 FNTA FNTB NUP133 NUP50 EIF4E NUP54 DHX9 NUP42 BST2 NUP43 RAE1 RANBP2 SOCS1 NUP35 SPHK1 NUP37 UBE2I SP100 IP6K2 CASP1 PIAS1 IRF5 SUMO1 CHUK UBA7 HSPA5 IFI6 EIF2AK3 UBE2L6 ISG15 IFI44L IFIH1 HERC5 IKBKB IFI27 TP53 TRIM25 ARIH1 IKBKG ATF6 RIGI FKBP5 IRF4 PPP2R5A PPP2CA PPP2CB PPP2R1B CIITA TRIM68 TRIM21 TRIM62 SAMHD1 TRIM46 TRIM48 TRIM45 TRIM35 TRIM38 TRIM31 TRIM34 TRIM29 TRIM26 TRIM22 TRIM17 DUS2 TRIM14 SOCS3 NCAM1 TRIM10 PTPN1 MT2A OAS2 FAAP24 FAAP20 SMAD7 GBP2 GBP1 FAAP100 GBP4 CENPX FANCM FANCL YBX1 FANCA FANCB CAMK2B GBP6 FANCE PGGT1B FANCG CAMK2D NEDD4 FANCF CAMK2A CAMK2G PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L RPL37A RPL23A RPL36A RPL35A RPL22L1 EEF1A1 EEF2 RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A RPL37 RPL39 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal ASCC3 MGMT ALKBH3 ASCC1 ALKBH2 FTO ALKBH5 ASCC2 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions NLRP3 CAV1 MAVS PALS1 RPS4X YWHAQ YWHAH PDPK1 RPS3A IRF3 TRAF3 TRAF6 RUNX1 YWHAE PCBP2 YWHAG RELA NFKB1 RPS15 RPS14 RPS17 UBA52 RPS16 TBK1 RPS19 RPS18 RPS11 RPS10 RPS13 UBB RPS12 BST2 UBC RPS27A RPS4Y2 IFIT1 PPIH RPS4Y1 IFIT3 PPIG IFIT2 RCAN3 SFN EP300 RIPK3 BCL2L1 PSMC6 UBE2I RPS26 RPS25 NFKBIA RPS28 PYCARD RPS27 RPS29 RPS20 CASP1 NMI RPS21 RPS24 RPS23 SP1 YWHAB PPIA IFIH1 IKBKE TOMM70 TRIM25 HNRNPA1 RIGI SFTPD YWHAZ EEF1A1 NPIPB3 SIKE1 KPNB1 TLR7 RPS27L RPS15A RPS3 RPS2 STING1 FAU NPM1 KPNA2 RPS9 RPS7 RPS8 PPIB RPS5 RPS6 SMAD4 RPSA SMAD3 ITCH FKBP1A TKFC IRAK2 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog CUL3 SYVN1 DERL2 IHH OS9 ULK3 DZIP1 SPOPL ARRB1 BTRC PRKACA SKP1 OFD1 SHH HHAT ERLEC1 UBA52 CUL1 PSMD12 PSMD11 UBB PSMD14 PRKAR2B PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 EVC2 IQCE PSMB3 PSMD2 EFCAB7 PSMD3 EVC DRC4 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 ARRB2 PSMC4 PSMC1 PSMC2 ADAM17 DISP2 SCUBE2 NOTUM GSK3B SEL1L SPOP GRK2 IFT172 GLI1 GLI3 GLI2 IFT52 SUFU PRKACG GPC5 IFT57 PRKACB DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 RBX1 IFT88 ADCY9 PRKAR1B SMO PRKAR1A GPR161 NUMB INTU ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 CDC73 ADCY7 ADCY6 ADCY5 KIF3A TTC21B PRKAR2A P4HB HHIP CSNK1A1 PTCH1 BOC GAS1 WDR19 CDON IFT122 SMURF2 FUZ SMURF1 ADCY10 ITCH GNAS MKS1 VCP DHH CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects PDE2A IRAG1 PRKG2 PDE11A PDE10A KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 PDE5A PDE9A ITPR1 PDE1B PDE1A PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection NLRP3 NFKB1 CTSG MEFV C3 NFKB2 P2RX7 PYCARD PSTPIP1 CASP1 HMOX1 TXNIP HSP90AB1 TXN SUGT1 ENTPD1 C3AR1 ENTPD5 IL18 IL1A IL1B P2RX4 GSDMD NT5E RELA PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSMA5 SEM1 PSMA6 PSMA3 PSME1 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMB10 PSMC2 PSMB8 PSMB9 PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 PSME2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors HPR HPX IGHA1 IGHA2 AMBP JCHAIN APOL1 HMGB1 HSPH1 COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO SCGB3A2 SAA1 SSC5D STAB1 CD5L COL1A1 S100A9 COL1A2 FTH1 HBA2 CD36 HSP90AA1 FTL HYOU1 APOA1 IGHV3-23 HP SPARC IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CALR IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 ALB IGHV3-13 CD163 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 SCARF1 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 PRDX1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 COL4A2 COL4A1 APOB COL3A1 MASP1 STAB2 APOE LRP1 HBB LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome KMT2D WDR5 DPY30 ASH2L RBBP5 S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase CDT1 CDC6 ESCO1 ESCO2 MYC LIG1 CCND1 CABLES1 WEE1 RFC5 RFC3 RFC4 RFC2 RBL2 E2F4 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 FEN1 CDC26 CDC27 CDCA5 ANAPC7 PDS5B PDS5A UBE2C WAPL UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 SMC3 ANAPC1 ANAPC2 RAD21 STAG1 STAG2 SMC1A UBA52 AKT2 AKT3 CCNE2 CCNE1 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC POLE RFC1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 POLD3 POLD4 POLD2 ADRM1 PSMA5 SEM1 PSMA6 POLE4 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 CDC25B POLE2 PRIM2 PSMC3 PSMA1 PRIM1 POLE3 PSMA2 POLA1 PSMC4 POLA2 PSMC1 PSMC2 CKS1B SKP2 MAX POLD1 DNA2 AKT1 CDK7 TFDP1 TFDP2 MNAT1 GSK3B CDKN1A E2F1 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 CDKN1B MCM4 MCM5 E2F5 MCM6 MCM2 RBX1 PCNA LIN54 LIN37 LIN9 LIN52 RPA1 RPA2 RPA3 PTK6 CDK4 CDK2 CCNA2 CCNA1 RBBP4 RB1 CCNH GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX BID BAX PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling CUL1 JAK2 RBX1 CSH1 PTPN11 PRL PRLR GHR GH2 STAT5A GH1 BTRC STAT5B SKP1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling PIK3R2 PIK3CB PIK3R1 MAP3K8 THEM4 FYN MAP3K14 PIK3CA RICTOR PRR5 PDPK1 PIK3CD CD28 PIK3CG AKT2 AKT3 MLST8 CD86 AKT1 MAPKAP1 CD80 TRIB3 LCK PIK3R3 MTOR PIK3R6 PIK3R5 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events EP300 CCNB2 WEE1 CCNB1 CDC25A RBBP4 CENPF LIN54 LIN37 CDC25C LIN9 LIN52 PLK1 FOXM1 MYBL2 PKMYT1 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism HNMT UROC1 CARNS1 CARNMT1 AMDHD1 HDC AOC1 HAL FTCD SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases H2AC14 TOMM20 VDAC3 HIF1A VDAC2 MYC TAB1 MDM2 RHOT1 MDM4 USP30 TRAF6 USP14 CLSPN IL33 USP18 BECN1 USP13 TNKS TNKS2 RNF146 USP15 USP17L4 USP17L5 USP17L8 CCP110 USP5 H2AC20 USP3 USP17L30 FKBP8 SNX3 USP37 ARRB1 USP34 USP47 USP48 USP49 USP42 USP44 PTRH2 USP16 USP12 WDR20 USP17L21 TRRAP USP17L20 H2AC17 USP17L22 H2AC12 USP19 USP24 USP17L15 HGS USP25 USP17L18 USP26 USP17L17 USP20 USP17L19 USP9X USP17L10 USP17L12 USP28 STAM2 USP17L3 USP17L11 TADA2B TRAF2 USP17L13 H2AC25 USP17L1 H2AC21 POLB RIPK1 KAT2A UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A TAF9B PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RUVBL1 PSMB2 PSMB3 TAF10 PSMD2 PSMD3 PSMB1 PSMD1 H2AC1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 ATXN7 PSMA4 H2AC8 CDC25A PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 ARRB2 PSMC4 NFKBIA PSMC1 USP11 PSMC2 SKP2 AR WDR48 RNF128 FOXO4 H2BC18 OTUB1 IFIH1 SUDS3 USP22 TP53 TOMM70 USP33 IKBKG PTEN RIGI TADA3 USP10 IDE AXIN1 H2BC26 KEAP1 USP8 H2BC21 MAT2B TGFBR1 DDB2 RNF123 VDAC1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 USP17L2 USP4 USP21 CFTR RCE1 CYLD H2BC11 SIAH2 MAP3K7 MUL1 GATA3 BIRC2 BIRC3 ADRB2 AXIN2 SMAD2 SMAD1 CDC20 SMAD4 SMAD3 SMURF2 CCNA2 CCNA1 SMAD7 USP7 USP2 UFD1 H2AC19 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS MUC16 MUC17 MUC19 C1GALT1 MUC12 MUC5B MUC15 MUC20 MUC21 MUCL1 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 C1GALT1C1 MUC13 MUC6 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events PDE3B AKT2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCA10 PEX3 ABCG4 ABCG8 ABCG5 ABCA2 ABCA5 ABCA9 ABCA6 ABCA7 ABCD3 APOA1 ABCD1 PEX19 ABCA12 ABCA3 ABCD2 ABCG1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation PIK3R2 PIK3CB PIK3R1 TGFB2 TGFB3 PRKCZ PDPN MPIG6B PLCG2 GP6 CLU AHSG PIK3CA PROS1 PTPN6 ITGB3 F13A1 CDC42 FGB LAMP2 FGA GP1BB TGFB1 FGG F2R F2 F5 F8 PECAM1 EGF SERPING1 PPBP KNG1 GP5 GNAI1 STXBP2 GP9 GNAI2 ORM1 ORM2 TRPC7 CAP1 TRPC6 TRPC3 FLNA VCL CFL1 APOOL TUBA4A SPARC SOD1 ABCC4 SHC1 PRKCH IGF2 QSOX1 PRKCQ CD63 ITPR1 ITPR2 SERPINF2 ITPR3 HRG RASGRP2 RASGRP1 PSAP MPL THPO LAT ADRA2B CYB5R1 LYN ALB A1BG SERPINA3 ACTN4 ADRA2C ADRA2A F2RL2 F2RL3 RAF1 SELP DGKG DGKE DGKD AKT1 DGKB DGKA PRKCD PRKCA YWHAZ ABHD12 PRKCE LCK DGKZ A2M SRC DGKQ DGKK DGKI DGKH ABHD6 STXBP3 STX4 MAPK14 CSK DAGLA PCDH7 TIMP1 RAP1A TTN MAPK1 ACTN1 DAGLB MAPK3 PFN1 P2RY1 SOS1 PIK3CG PLG PTK2 RAC2 AAMP VAV3 RHOG VAV1 BRPF3 GNAT3 VAV2 RHOB SYK VEGFA GNAI3 CFD FYN CD109 ALDOA PDGFB PDPK1 SERPINE1 P2RY12 PTPN11 ARRB1 TBXA2R GNA12 PIK3R3 PIK3R6 PIK3R5 CLEC1B FN1 CD36 CALM1 LCP2 APOA1 ISLR HABP4 CHID1 RAPGEF3 GTPBP2 SYTL4 TAGLN2 RAPGEF4 NHLRC2 TEX264 ENDOD1 APOH VTI1B MANF CALU MAGED2 FERMT3 ACTN2 ECM1 OLA1 CTSW SERPINA4 TMSB4X TIMP3 GNG10 ANXA5 TOR4A SPP2 LEFTY2 PF4 IGF1 LY6G6F GNG12 VEGFB GNG11 VEGFC GNG13 VEGFD LHFPL2 ITGA2B PCYOX1L GNB2 POTEKP GNAQ MMRN1 FAM3C GNB1 APLP2 TMX3 SELENOP GNB4 SCG3 GNB3 RARRES2 CYRIB GNB5 SCCPDH LGALS3BP PRKCG WDR1 GNGT1 PLEK PHACTR2 SRGN GNGT2 ITIH4 ITIH3 CLEC3B CDC37L1 CD9 APP ARRB2 GNA14 GNA13 GNG3 GNA15 GNG2 GNG5 APBB1IP GNG4 GAS6 GNG7 HSPA5 GNA11 GNG8 PPIA RAP1B HGF TF TLN1 RAB27B RAC1 RHOA GP1BA CRK PTPN1 BCAR1 VWF FCER1G SERPINA1 PLA2G4A THBS1 MGLL PRKCB DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g ALG12 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) H2AC14 STAT3 H2BC12L RPS6KA3 CXCL8 RPS6KA2 RPS6KA1 H2AC8 H2AC6 H2AC7 CDKN2D CDKN2C IGFBP7 CDK6 H4C9 H2AC20 IL1A H2AX CEBPB ANAPC15 CDKN1A ANAPC16 UBE2D1 ANAPC10 RELA ANAPC11 H2BC26 FZR1 JUN CDC23 CDC26 CDC27 VENTX H2BC21 H3-3B ANAPC7 MAPK7 UBE2C H3C8 CDKN2A CDKN1B UBE2E1 NFKB1 IL6 UBE2S CDC16 FOS ANAPC4 ANAPC5 ANAPC1 ANAPC2 H2BC17 MAPK1 H2BC12 H2BC13 H2BC14 MAPK3 H2BC15 H2AJ UBA52 H2BC11 CDKN2B H3C15 UBB CDK4 CDK2 CCNA2 CCNA1 UBC H2BC9 H2BC8 H2BC5 H2BC3 RPS27A H2BC1 EHMT2 H2AC19 EHMT1 H2AB1 H2AZ2 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders CALM1 NCOR2 GPS2 TBL1X HDAC3 HDAC1 PRKACA NCOR1 CAMK4 TBL1XR1 SIN3A STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines STING1 STAT6 TBK1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation GALNT3 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF2 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins TNS3 HGF MET ITGB1 TNS4 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer SHC1 GAB1 CDC37 UBB EGF NRAS PIK3R1 PLCG1 EGFR UBC RPS27A PIK3CA UBA52 SOS1 HRAS CBL HSP90AA1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane SACM1L MTMR2 SBF1 PI4K2B PI4KA PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling STAT3 FANCC SPHK1 MAVS UBE2I SUMO1 CHUK UBE2L6 ISG15 HERC5 NCK1 ILF2 IKBKB HSPA1L TP53 TRIM25 ADAR ARIH1 IKBKG ILF3 PPP2R1A EIF2AK2 PPP2R5A HSPA8 PPP2CA EIF2S3 PPP2CB HSPA1A EIF2S2 EIF2S1 PPP2R1B SNCA HSPA2 STAT1 NPM1 DUS2 PTPN2 CENPS DHX9 FAAP24 DNAJC3 FAAP20 FAAP100 CENPX FANCM FANCL FANCA FANCB HSPA1B FANCE FANCG FANCF TARBP2 MAP2K6 PRKRA CDK1 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function ZC3H12A CDH19 JUP CTNND1 CTNNA1 SOX10 CTNNB1 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling GNAT3 ZDHHC7 BCL2 ELK1 SPHK1 CAV2 PIK3R2 NRAS PIK3R1 CAV1 GNAI3 PRKCZ ESR1 PIK3CA GNG3 GNG2 GNG5 GNG4 PDPK1 FOXO3 GNG7 GNG8 STRN S1PR3 XPO1 CCND1 AKT1 NOS3 PRMT1 EGF AREG EGFR ZDHHC21 UHMK1 GNAI1 GNAI2 EPGN SRC SRF PIK3R3 HSP90AA1 CALM1 CDKN1B FOS MMP7 EREG BTC MAPK1 MMP2 MMP3 MAPK3 MMP9 HBEGF AKT2 AKT3 GNG10 PTK2 GNG12 ESR2 GNG11 GNG13 TGFA GNB2 GNB1 GNB4 GNB3 IGF1R GNB5 GNGT1 HRAS GNGT2 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL ACVR2A LEFTY1 CRIPTO3 CFC1 NODAL DAND5 LEFTY2 ACVR1B CER1 ACVR1C CRIPTO ACVR2B DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG MTRR MTR MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing EIF4A3 CASC3 MAGOH SRRT THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 SRRM1 THOC6 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 HNRNPC GTF2F1 SLU7 GTF2F2 SRSF7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 U2AF2 CCAR1 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB PCBP1 PCBP2 RNPS1 PPP1CB SYMPK RBM10 DHX15 TCERG1 DDX46 NUDT21 DDX42 RBM17 NCBP1 NCBP2 HTATSF1 FUS CSTF2T PABPN1 PPP1R10 SMNDC1 UBA52 U2SURP PRPF40A HNRNPA3 CLP1 SNRPD2 SNRPD1 HNRNPF TUT1 HNRNPA2B1 SNRPD3 PPP1R8 CPSF7 SNRPA1 SRSF10 XRN2 SRSF12 POLR2A UBB POLR2B SF3B1 PAPOLG DHX9 POLR2C POLR2D UBC SF3B4 SF3B5 SF3B2 POLR2G SUGP1 SF3B3 SF3B6 POLR2I RPS27A POLR2J SF3A3 SNRPC SF3A1 SNRPA SF3A2 SRSF8 PPP1CA CHERP RBM25 SNRNP70 HNRNPU PUF60 HNRNPR SNRPB2 RBM39 HNRNPL HNRNPK HNRNPD TRA2B PCF11 WDR33 PHF5A PTBP1 PAPOLA HNRNPH1 SNRPN HNRNPA1 HNRNPM DNAJC8 FIP1L1 SRRM2 RBBP6 CSTF3 CSTF2 CSTF1 HNRNPH2 RBMX CPSF4 CPSF1 CPSF3 CPSF2 RBM5 SNRPG SNRPE YBX1 SNRPF POLR2E POLR2F POLR2H SNRPB DDX5 POLR2K POLR2L PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport BSG SLC16A7 SLC16A1 SLC16A8 EMB SLC16A3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL PPP2R1B PPP2R5E APOB LRP8 FGR PECAM1 PTPN11 PLA2G4A PPP2R1A PTPN6 PPP2R5B PPP2R5A PPP2R5D PPP2R5C MAPK14 PPP2CA PPP2CB MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing PQBP1 EIF4A3 CASC3 MAGOH SRRT CDC40 SRRM1 SNRNP200 DDX39B SRSF2 SRSF3 SRSF4 CTNNBL1 SRSF5 HNRNPC SRSF6 SLU7 SRSF7 SRSF9 PRCC RBM8A SRSF1 U2AF1 U2AF1L4 U2AF2 CCAR1 DHX38 SRSF11 ALYREF UPF3B MAGOHB PCBP1 PCBP2 RNPS1 RBM10 DHX15 DHX16 WBP11 DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 U2SURP SNRPD2 SNRPD1 HNRNPF HNRNPA2B1 SNRPD3 SNRPA1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 CHERP PUF60 SNRPB2 AQR PRPF19 PTBP1 HNRNPH1 EFTUD2 HNRNPA1 HNRNPM HSPA8 ZCRB1 SNRPG SNRPE SNRPF SNRPB DDX5 GTF2F1 GTF2F2 STEEP1 TCERG1 GPATCH1 PNN ZNF830 SF1 DHX8 PRKRIP1 CWF19L2 NCBP1 SNU13 RNPC3 NCBP2 HTATSF1 FUS WDR70 DHX35 ISY1 ZRSR2 PRPF38A SMU1 BCAS2 NKAP UBL5 PRPF40A HNRNPA3 GCFC2 GPKOW PRPF18 CDC5L SDE2 FAM32A CACTIN PPP1R8 SRSF10 SRSF12 PRPF31 PDCD7 POLR2A SF3B1 RBMX2 POLR2B DHX9 SNIP1 POLR2C SNRNP35 POLR2D IK PRP4K LENG1 POLR2G SUGP1 PRPF4 PRPF3 POLR2I SNRNP27 SNRNP25 POLR2J SNRPC SNRPA SRSF8 ZMAT2 ZMAT5 CCDC12 YJU2 LSM5 LSM4 LSM3 LSM2 PPIE LSM8 PPIH LSM7 PPIG LSM6 RBM25 PPWD1 DDX41 USP39 MTREX SART1 SNRNP70 TFIP11 SYF2 LUC7L3 HNRNPU C9orf78 NSRP1 HNRNPR WBP4 RNF113A RBM39 PPIL2 MFAP1 RBM42 ACIN1 HNRNPL SNRNP48 HNRNPK BUD13 HNRNPD TRA2B FAM50A PHF5A TXNL4A SNRPN PLRG1 DNAJC8 PPIL1 SNRNP40 PPIL3 PPIL4 SRRM2 CRNKL1 SNW1 HNRNPH2 RBM7 CWC25 CWC27 CWC22 PRPF6 PRPF8 RBMX CWC15 RBM5 YBX1 POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase COMT MAOA FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMC3 SGCE SGCD SGCA SGCB SGCG SNTA1 LAMA2 LAMA4 LAMB2 SGCZ AGRN LAMA1 SNTB1 SNTB2 DTNA DTNB HSPG2 SSPN LAMA5 LAMA3 DRP2 DMD LAMB3 LAMB1 DAG1 UTRN LAMC2 LAMC1 SNTG2 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis POMC CYP17A1 LHB HSD17B12 CGA HSD3B2 HSD3B1 HSD17B3 SRD5A2 SRD5A1 SRD5A3 DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells LAMA5 LAMC3 LAMA3 EGF LAMB3 LAMB1 LAMA2 LAMA4 LAMB2 LAMA1 VTN LAMC2 LAMC1 FN1 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants FLT3 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP POLB OGG1 NEIL2 LIG3 NEIL1 XRCC1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP9 GP1BA ADAMTS13 VWF GP1BB GP5 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate PNPO PDXK AOX1 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 NRAS FGF1 FGF7 FGF4 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 TLR10 APP MAP3K8 DUSP6 MAP2K3 DUSP7 MEF2A MAP2K4 NFKB2 UBE2N MEF2C TAB3 MAPKAPK3 NFKBIA TAB2 MAPK9 TAB1 ATF2 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 CHUK NKIRAS2 IKBIP IRAK4 PELI1 LRRC14 TRAF6 USP14 PELI3 PELI2 IKBKB NLRC5 TP53 USP18 TIFA MAP3K1 IKBKG S100B RIPK2 SAA1 NOD1 NOD2 MAPKAPK2 PPP2R1A BTRC PPP2R5D RELA MAPK14 SKP1 PPP2CA JUN MAPK11 PPP2CB PPP2R1B MAPK7 FBXW11 NFKB1 FOS TLR5 MAP2K1 TRAF2 MAPK1 CASP8 MAPK3 UBA52 MAP3K7 CUL1 UBB UBC RPS27A ECSIT UBE2V1 MAP2K6 IRAK1 IRAK2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling NRG3 PIK3CA NRG4 PIK3R1 HBEGF NRG1 NRG2 EREG BTC NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) H2BC12L PIAS4 RNF168 DCLRE1C UBE2N RIF1 POLL MDC1 NHEJ1 POLM TDP2 TDP1 KAT5 PAXIP1 LIG4 UBE2V2 H4C9 BARD1 XRCC6 XRCC4 XRCC5 ATM H2AX PRKDC RAD50 BRCA1 H2BC26 H2BC21 HERC2 BRCC3 BABAM1 BABAM2 UIMC1 H2BC17 ABRAXAS1 RNF8 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 NSD2 MRE11 H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 H2BC1 TP53BP1 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy DUSP16 RAB7A RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 TBP BRF2 BDP1 POLR1C POLR1D CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H POLR3K POLR2H POLR2K ZNF143 POLR2L POU2F1 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHA BCKDHB DLD DBT COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism MTRR MMACHC MMAA MMADHC MMAB MTR MMUT DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins NUP37 PIAS4 RNF168 NSMCE4A UBE2I SP100 MDC1 NUP107 NUP188 PIAS1 RAD52 SUMO1 SUMO3 SUMO2 NUP210 NUP93 NUP205 POM121 BMI1 NUP214 AAAS RING1 NUP160 POM121C CETN2 NUP85 TPR NUP88 XRCC4 RNF2 NUP155 HDAC7 NUP153 CBX8 PHC2 PML PHC1 BRCA1 CBX4 CBX2 NUP62 PHC3 CDKN2A HERC2 NDC1 SEC13 SMC3 NUP133 RAD21 WRN STAG1 PARP1 STAG2 SMC1A NUP50 NUP54 RPA1 PCGF2 NUP42 NUP43 RAE1 TDG RANBP2 SMC5 SMC6 BLM NSMCE3 NSMCE2 XPC NSMCE1 NUP35 EID3 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease ERCC3 ELK1 PQBP1 VAMP1 ERCC2 RNASEK SRRT MAP2K4 KPNA7 KPNA4 KPNA5 MAPK8 KPNA3 MAP2K7 CLU SNRNP200 CTNNBL1 SIGMAR1 PRCC MERTK KDELR1 CCAR1 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 TLR1 SYMPK RBM10 PAF1 CALM3 CALM2 RETREG1 DHX15 TLR2 DHX16 CD33 LTF HBA2 SH3GL3 SH3GL1 ZBP1 WBP11 CD8B HNRNPUL1 RTN3 DDX3X DDX46 DDX42 RBM17 DYNLT1 BUD31 RBM22 DDX23 CSTF2T RRBP1 SMNDC1 U2SURP CLP1 CD4 TYRO3 PSMD12 PSMD11 MRC1 PSMD14 PSMD13 SF3B4 SF3B5 ARF1 SF3B2 RPLP1 PSMA7 SF3B3 RPLP0 SF3B6 PSMB6 BRD4 PSMD8 SF3A3 SF3A1 PSMB7 SF3A2 PSMB4 XAB2 PSMD6 RPLP2 PSMB5 HSPA1B PSMD7 CLEC4M PSMB2 CLEC5A PSMB3 PSMD2 NCL PSMD3 VTN PSMB1 PSMD1 BAG2 CHERP RCAN3 ADRM1 EIF4G3 PSMA5 EIF4G2 EIF4E3 SEM1 PSMA6 DUSP16 PSMA3 PSMC5 CX3CR1 PSMA4 PSMC6 VAMP2 PSMC3 PUF60 PSMA1 SNRPB2 PSMA2 PSMC4 PSMC1 AQR PSMC2 C4B_2 CTNNB1 NMI SH3KBP1 PRPF19 PCF11 PACS1 YWHAB MAPRE3 ELAVL1 XPO1 AKT1 AXL HDLBP NUP214 EFTUD2 PDIA3 YWHAZ CD300A XRN1 DPM1 DPM2 PABPC1 DPM3 RPL22L1 DNAJC10 ELAVL2 UPK1A S1PR1 NHERF4 HSPA8 KPNB1 ITGA4 MAPK14 HSPA1A EIF4G1 PRKACG PRKACB RBX1 ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A CSNK1A1 ITCH GNAS SLC25A4 YES1 CUL3 C3 CCNK CCNT2 NUP107 CCNT1 NUP188 GTF2B RCC1 BANF1 KPNA1 SUPT16H LIG1 NUP210 LIG4 GTF2F1 GTF2F2 RPL23A NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 POM121 TSG101 AHCYL1 SUPT4H1 NEDD4L AAAS GTF2E1 GTF2E2 NUP160 POM121C ENTPD1 NUP85 TPR NUP88 XRCC6 ENTPD5 XRCC4 NUP155 XRCC5 VTA1 HMGA1 ELOA2 STX1A NUP153 SUPT5H CDK9 CHMP2B CHMP2A NMT1 TAF4B NMT2 FEN1 ELL TAF7L NUP62 ELOA NELFB ELOB NELFCD NELFA ELOC CCR5 NELFE TAL1 NDC1 SEC13 PDCD6IP NCBP1 NUP133 RPL27A NCBP2 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 CHMP3 NUP54 WASL CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 TAF1L POLR2A POLR2B NUP42 POLR2C POLR2D MVB12B MVB12A POLR2G NUP43 POLR2I TAF9B POLR2J RAE1 RANBP2 RANBP1 RNGTT TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 UBAP1 PPP1CA TAF7 NRBP1 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 GGT1 RAN TAF2 NUP37 TAF1 DPEP2 DPEP1 CHUK UBA7 HSPA5 UBE2L6 GGT5 ISG15 IFIH1 HERC5 IKBKB TRIM25 ARIH1 IKBKG RIGI CLTC CLTA AP2A1 AP2B1 AP2A2 AP2S1 SH3GL2 PARP1 RPL26L1 RPL4 ITGB1 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 ENO1 RPL8 RPL6 RPL7 SMAD4 RPL36 SMAD3 RPL35 RPL38 RPL37 RPL39 YBX1 CAMK2B CAMK2D RPL21 CAMK2A RPL23 RPL22 MED8 MED9 CAMK2G ACOT2 RPL24 RPL27 PIK3R1 RPL26 RPL29 RPL28 JAK3 PLCG2 PTPN6 PROS1 CDK19 RPL41 RPL3L TGFB1 F2 RUNX1 EIF2AK2 PRKX RELA RPL10 RPL12 RPL11 RPL14 RPL13 NFKB1 RPL15 IL6 RPL18 RPL17 RPL19 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 RPS16 TBK1 RPS19 SNRPD2 RPS18 SNRPD1 AKT2 AKT3 SNRPD3 RPS11 B2M GOLGA7 RPS10 RPS13 VPS39 RPS12 VPS18 HLA-H ST6GAL1 IPO5 HLA-B GRSF1 DNAJC3 HLA-C MOGS HLA-A ATG14 HLA-F ITPR1 HLA-G ITPR2 HLA-E ACE2 RPS4Y2 SDC4 ITPR3 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 RPS4Y1 IFIT1 LARP1 IFIT3 VPS11 IFIT2 VPS36 ST3GAL4 SFN SNF8 VPS25 ST3GAL1 ST3GAL2 VPS16 ST3GAL3 SRPK2 EDEM2 PARP16 PARP14 SRPK1 PARP10 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPL7A RPS20 RPS21 RPS24 ATP1B3 RPS23 IFNA5 ATP1B2 NRP1 ATP1B1 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 MAGT1 RPL37A IFNA8 MAP1LC3B TRIM4 HAVCR1 IKBKE JAK1 TOMM70 RPL36A PARP6 PARP4 PRMT1 RIPK2 SFTPD TXNRD1 ANO8 RPL35A ANO9 ANO6 TYK2 ANO7 IMPDH1 ZDHHC11 ANO4 IMPDH2 PARP9 ANO5 IL17RC ANO2 PARP8 ANO3 IL17RA ANO1 SIKE1 CANX TLR8 TLR7 FXYD4 ZDHHC20 RPS27L FXYD3 TMPRSS2 RNF135 FXYD2 RPS15A GPC1 FXYD1 MGAT5 FXYD7 RPS3 FXYD6 GPC3 ANO10 GPC2 GPC5 MGAT1 RPS2 GPC4 MGAT2 GPC6 STAT1 IFNB1 STAT2 TJP1 NLRP12 STING1 ZDHHC9 IL17F FAU AGRN CRB3 IL17A ATP1A4 TUSC3 ATP1A3 GEMIN2 KPNA2 ATP1A2 MAP3K7 RPS9 ATP1A1 IFNA14 RPS7 RPS8 IFNA16 RPS5 VPS33A IFNA17 RPS6 VPS33B RPSA SCAP ZCRB1 TUFM TMEM258 GEMIN4 RPL39L SNRPG GEMIN5 GEMIN6 SNRPE UBE2V1 GEMIN7 MASP1 SNRPF GEMIN8 ISCU IFNA10 IFNAR1 SNRPB FKBP1A VCP DDX5 FUT8 IGHG3 TKFC IGHG4 IRAK1 CYSLTR1 IRAK2 IGHG1 CYSLTR2 MAN2A1 G3BP1 IGHG2 GNAT3 SMN2 G3BP2 GNAZ CD3G NLRP3 IFNA21 FCGR3A SYK UVRAG OST4 FGR CAV1 HCK ADORA2B MAVS GNAI3 OSTC FYN STT3A FCGR1A UBE2N FCGR2A TAB3 TAB2 TAB1 STT3B PALS1 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH RPS4X YWHAQ NFKBIB MBL2 YWHAH PDPK1 RPS3A DDOST IRF3 TLR9 DAD1 TRAF3 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB VHL SEC24B SEC24A CNBP GALNT1 PTPN11 MGAT4C MGAT4A MGAT4B CLINT1 VPS41 AP1G1 VPS45 SEC24D SEC24C AP1S2 AP1S1 AP1S3 AP1B1 CALM1 RAB5C AP1M2 AP1M1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 WNT5A GNGT2 FZD7 MEFV NFKB2 P2RX7 PYCARD PSTPIP1 CASP1 TXNIP GNG3 SUGT1 GNG2 GNG5 GNG4 GNG7 GNG8 MET NFE2L2 EEF1A1 EEF2 STX1B JUN KEAP1 SNW1 KDM1A RAC1 SFPQ ELMO1 RNF213 ELMO2 DOCK1 ATG7 CRK HBEGF PHF21A CBL RCOR1 FASN HBB HMG20B EIF4A3 JAK2 CDC40 SRRM1 SRSF2 SRSF3 SRSF4 DOCK2 SRSF5 SRSF6 CDC42 SRSF7 CUL5 SRSF9 UBA6 UBA5 UBR4 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 GUCY2C ALYREF RNPS1 UBA3 UBA1 NOS2 CORO1A HGS ATP6V1H RAB7A LY96 PAK2 IL10 RIPK1 CD14 TLR4 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 HNRNPF HNRNPA2B1 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 SNRPA1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 RIPK3 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 CD163 PLK2 MLKL IGLV7-43 IGKV1D-12 RHBDF2 NFKBIA MYH9 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 DAXX IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 PTBP1 V1-5 V1-3 IGKV3D-20 V5-6 HNRNPH1 MAPKAP1 IGLV3-19 HNRNPA1 IGKV2-30 IGHV2-70 HNRNPM IGHV2-5 IGLV3-1 CTNND1 IGHV3-48 IGLV3-25 CBLL1 EPS15 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 V4-6 MYH2 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 RPTOR MAP2K1 MAP2K2 MAPK1 MAPK3 RICTOR NPM1 SOS1 P4HB GSDMD PRR5 MLST8 TRIM27 MED19 MED15 MED18 C3AR1 IL18 IL1A MED11 IL1B P2RX4 MTOR PML TLR3 MED26 EIF4A2 MED29 EIF4A1 H2AC17 MED28 H2AC12 MED22 MED25 MED21 H2AC25 H2AC21 PABPN1 EIF4E ARID4A H2AC1 BRMS1 UBE2I PGK1 NR3C1 SUMO1 H2BC18 SP1 PPIA REST SNAP25 SLC25A5 CSNK2A1 CSNK2A2 SLC25A6 ROCK1 CSNK2B RBMX EXOC1 CYFIP2 CYFIP1 NCKAP1 GBF1 WIPF1 WIPF2 WIPF3 NPLOC4 UFD1 MED13L DYNC1LI1 DYNC1LI2 NCKAP1L HNRNPC NOX1 ARPC1B ARPC1A PLCG1 EGFR YWHAE DYNLL2 PPP1CB GNAI1 GNAI2 NEK2 BTRC PRKACA YWHAG SKP1 HSP90AA1 TUBB CBX1 DYNLL1 FKBP4 ABI2 TAOK1 UBA52 ABI1 DYNC1I2 UBB PRKAR2B UBC RPS27A DYNC1H1 DVL1 DVL2 DVL3 BCL2L1 ARPC4 ARPC5 ARPC2 ARPC3 CDH1 NOXA1 IFNGR1 IFNGR2 BRK1 HSPG2 NCK1 ADAM17 ACTR3 ACTR2 LCK SRC ROCK2 WASF1 WASF2 WASF3 CTSL BAIAP2 CTSG HMOX1 BTK MMP9 PPIB FURIN STAM PTK2 P4HA1 P4HA2 P4HA3 SYT1 RB1 CCNH VAV3 H2AC19 CCNC ACTB VAV1 H2AC14 VAV2 TRIM28 MED1 MED4 MED6 MED7 RPL10L RPL10A WAS NOXO1 PPP1CC CD28 CREBBP DYNC1I1 H4C9 BCAP31 MYO9B H2AC20 CASP4 EZH2 RAB5A MED16 ACTG1 MED17 MED12 MED14 MED13 MED10 HYOU1 PRKG2 H3C8 ATL2 CYBA CRBN NUDT21 FNTA FNTB STAM2 APOA1 MED27 LY6E RPL13A FUS MED23 NACA ISY1 NCOR2 BCAS2 C1S MED24 HNRNPA0 HNRNPA3 NCKIPSD NCOR1 GPKOW CDC5L MED20 PDCD1 C4A CPSF7 GPS2 H3C15 TBL1X SF3B1 DHX9 MBD3 BST2 SUZ12 CD209 H2BC9 H2BC8 CALR H2BC5 SUGP1 IGHM H2BC3 H2BC1 GTF2H1 GTF2H2 GTF2H3 IGHD GTF2H4 PEX19 GTF2H5 GATAD2B GATAD2A IGF1R IL6R DNAJB11 RPL18A PPIE RPL36AL PPIH PPIG SYT2 ARID4B EP300 SUN2 SV2C SV2B SV2A CD9 H2AC8 HNRNPU H2AC6 HNRNPR H2AC7 SAP30 MAP1B TBL1XR1 BTF3 HNRNPL HNRNPK HNRNPD TXN WDR33 MED30 GAS6 MED31 EPCAM PHF5A AUP1 IPO7 ABL1 PAPOLA TXNL4A VIM SNRPN SUDS3 RAB5B CDK8 CDK7 PLRG1 SKIC8 DNAJC8 CEBPD FIP1L1 SEC11A MNAT1 SEC11C PPIL1 SNRNP40 GSK3B DNAJA2 NPIPB3 PPIL3 NT5E PSIP1 PPIL4 PPIL6 CHD4 SRRM2 CHD3 IL1R1 COG1 CRNKL1 H2BC26 CSTF3 CSTF2 H2BC21 CD79B CD79A CSTF1 PTGES3 CHMP1A HNRNPH2 TLR6 TBP EED C1QA EMC4 H2BC17 SPCS3 SPCS2 H2BC12 SPCS1 H2BC13 CWC25 H2BC14 CWC27 H2BC15 CWC22 COMT H2BC11 PRPF6 PRPF8 CPSF4 CPSF1 CDC73 RPL9P9 CPSF3 CPSF2 CWC15 HDAC2 HDAC3 CGAS BLNK LEO1 HDAC1 RBM5 OAS2 MTA1 GBP2 GBP1 RBBP4 GBP4 C4BPA C4BPB SAP30L CLDN1 POLR2E GBP6 POLR2F SAP18 POLR2H RBBP7 MTA2 MTA3 POLR2K GRPEL1 POLR2L SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses NLRP3 RIPK3 NFKB1 MAVS NFKBIA PYCARD CASP1 NMI STING1 UBA52 TBK1 KPNA2 IRF3 TRAF3 TRAF6 IFIH1 PPIB PPIA IKBKE TOMM70 TRIM25 RUNX1 UBB SFTPD BST2 RIGI UBC ITCH PCBP2 RPS27A NPIPB3 SIKE1 FKBP1A RELA TLR7 KPNB1 IFIT1 TKFC PPIH IFIT3 PPIG IFIT2 IRAK2 RCAN3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA NUP62 NUP37 SLBP NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP107 NUP188 EIF4E NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NXF1 NUP42 AAAS NUP160 ALYREF POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate SLC35D2 UGDH UXS1 UGP2 SLC35D1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions YBX1 LYN TSG101 KDELR1 CLINT1 FURIN NCL GBF1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 GPC1 GPC3 GPC2 GPC5 NCAN GPC4 BGN GPC6 VCAN SDC1 B3GALT6 SDC4 CSPG5 DCN AGRN SDC2 SDC3 HSPG2 BCAN ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT TOMT COMT MAOA TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 TGFBR2 TGFB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy DYNC1LI1 CETN1 TOMM20 DYNC1LI2 TOMM22 UVRAG MAP1LC3A FUNDC1 ATG9A ATG12 VDAC3 VDAC2 UBE2N TOMM40 ATG5 RHEB MTERF3 TOMM7 TOMM5 TOMM6 HSP90AB1 NBR1 PEX5 MFN1 USP30 MFN2 LAMP2 SQSTM1 CHMP4C CHMP4B CHMP4A MLST8 DYNC1I1 VPS28 PIK3C3 TSG101 WIPI1 BECN1 MTMR14 PRKAG2 DYNLL2 PRKAA1 CHMP2B MTOR CHMP2A HSP90AA1 MTMR3 DYNLL1 VPS37C VPS37D VPS37A VPS37B CHMP3 UBA52 UBE2D2 CHMP6 TBK1 OPTN CHMP7 DYNC1I2 PLIN2 UBB UBC MVB12B MVB12A PCNT RPS27A UBE2D3 ATG14 DYNC1H1 PARK7 PIK3R4 UBAP1 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 PRKAB1 RNASE1 RRAGA RRAGC ATG101 RRAGB GFAP ATG16L2 RRAGD ATG16L1 MAP1LC3B GABARAPL2 WDR45 MAP1LC3C RB1CC1 WIPI2 TOMM70 ATG4C ATG4B ATG4A ATG4D WDR45B AMBRA1 ULK1 EEF1A1 GABARAP HDAC6 CSNK2A1 ATM CSNK2A2 ARL13B HSPA8 PRKAG1 CSNK2B PRKAG3 RPTOR UBE2L3 TSC2 TSC1 PRKAA2 PINK1 VDAC1 IFT88 CFTR ATG7 EPAS1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKN UBE2V1 PRKAB2 PLIN3 HSF1 VCP SLC38A9 HBB DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFA1B DEFB105B DEFB104B DEFA6 DEFB1 DEFA4 DEFA5 DEFB136 DEFB109B DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 PRSS2 DEFB108B CCR6 DEFB108C CD4 PRSS3 CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SNRPF LSM10 LSM11 SNRPB SLBP SNRPG ZNF473 NCBP1 NCBP2 SNRPE SNRPD3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import TOMM20 TOMM22 TOMM40 TOMM7 ATP5MC1 TOMM5 TOMM6 CYC1 SAMM50 ATP5F1A ATP5F1B ACO2 TOMM70 OTC MTX1 CHCHD4 CHCHD5 CHCHD7 TIMM17B COA6 CMC4 CMC2 PAM16 TIMM23 TIMM21 TIMM13 TIMM50 PITRM1 GRPEL2 DNAJC19 COA4 TIMM8B SLC25A6 TIMM8A CHCHD10 TIMM44 GFER HSPA9 TIMM10B FXN CHCHD2 LDHD TIMM17A TIMM22 TIMM9 TIMM10 VDAC1 PMPCB PMPCA MTX2 HSCB CHCHD3 COX19 IDH3G CS BCS1L COX17 SLC25A12 SLC25A4 SLC25A13 NDUFB8 HSPD1 GRPEL1 COQ2 TAFAZZIN VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport SEC16A CAPZB KIF13B SEC23IP CNIH1 CNIH2 KIF1C FOLR1 KIF1B CNIH3 KIF1A IL7R BET1 KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIFC2 KIF2A KIFC1 SPTB KIF2C KIF2B CENPE KDELR1 KIF26A CAPZA1 GCC2 KIF26B CAPZA2 ANK2 SPTBN4 SPTBN5 SEC31A COL1A1 COL1A2 S100A9 HBA2 COPB1 SH3GL3 SH3GL1 HGS RAB7A RALA SPTA1 DCTN1 IGHV3-23 HP SPARC IGLV VAMP7 IGLV2-8 IGKV1-16 CD4 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 SURF4 ARF3 V2-19 ARF1 IGKV1D-33 IGKV2D-28 IGKV4-1 CD3D IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 GOLGA2 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 VAMP2 CD163 IGKV1D-16 IGLV7-43 IGKV1D-12 GOLGA4 SEC22B MYH9 IGLV1-51 GRIA1 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 SH3KBP1 IGHV4-39 NSF IGKV2-29 IGKV2-28 IGLC3 IGLC1 PRKAB1 IGLC2 V1-9 V5-4 V1-7 YWHAB V5-1 V1-5 AVP V1-3 IGKV3D-20 CUX1 V5-6 AKT1 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 PRDX1 IGLV3-1 IGHV3-48 YWHAZ IGLV3-25 IGLV3-27 EPS15 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 V4-6 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 STXBP3 HSPA8 PRKAG1 STX4 CHM PRKAG3 SPTBN2 KIF3A APOB CTSC CAPZA3 ACTR10 TGFA PRKAB2 LRP1 DCTN6 DCTN5 DCTN4 LRP2 PIP5K1C HSPH1 CHMP4C CHMP4B CHMP4A VPS28 COLEC12 MSR1 COLEC11 SCARA5 TSG101 HSP90B1 MARCO SCGB3A2 PRKAG2 VTA1 CHMP2B CHMP2A AP4M1 AP1G2 DNASE2 CLVS2 AP4S1 CLVS1 SEC13 VPS37C VPS37D VPS37A VPS37B CHMP3 WASL CHMP6 CHMP7 CHMP5 VPS4B VPS4A MVB12B MVB12A ANK1 MAN1A2 MAN1C1 MAN1A1 UBAP1 SBF1 SBF2 SCARF1 DENND5B RABGEF1 RINL TRAPPC12 TBC1D10C TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 TRAPPC2L SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 RAB35 TBC1D24 TBC1D25 ULK1 RAB38 CLTC DENND6B CLTA RIN3 AP2A1 DENND6A RIN1 AP2B1 RIN2 GABARAP AP2A2 TBC1D13 DNM1 TBC1D14 DNM2 TBC1D17 DNM3 AP2S1 RAB6B TBC1D15 SH3GL2 TBC1D16 TRAPPC2 TRAPPC3 TRAPPC1 ANKRD27 DENND4B CCZ1B DENND4A TRAPPC4 DENND4C HPS1 TRAPPC5 RAB39A CCZ1 RAB3IP HPS4 RAB27A RAB39B PRKAA2 RAB27B TRAPPC8 ARF4 TRAPPC9 MON1A MON1B PLA2G6 DENND1C INS DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D DENND2C DENND2B DENND2A CPD RAB3IL1 RAB33A RAB33B EXOC8 TRAPPC6A EXOC7 TBC1D2 RABEP1 PICALM TBC1D3 TRAPPC6B ARFGAP1 TBC1D7 RAB7B ARF6 EXOC4 RAB1A EXOC3 RABGAP1 EXOC6 RAB1B EXOC5 DENND3 EXOC2 RAB21 GGA2 EXOC1 GGA1 ALS2CL GGA3 ITSN2 CHML PREB RIC1 TRAPPC10 KDELR3 GBF1 RAB11B STX16 RGP1 RAB10 RAB11A GOSR1 TFRC GOLIM4 RAB12 RAB13 CYTH3 RAB18 PLA2G4A CYTH2 ITSN1 RAB41 RAB3GAP2 GOLGA5 RAB3GAP1 CYTH4 FNBP1L STX6 APOE VTI1A CYTH1 COG8 COG7 COG6 COG5 COG4 FNBP1 COG3 COG2 BET1L RAB30 RAB36 GOSR2 DYNC1LI1 ALPP AGPAT3 DYNC1LI2 HPR HPX IGHA1 IGHA2 AMBP JCHAIN APOL1 GJC1 GJC2 GJA3 MYO6 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 ARPC1A F5 F8 EGF EGFR YWHAE NEDD8 DYNLL2 LDLRAP1 ACTR1A SCARB2 AGFG1 VAMP3 KIAA0319 TOR1A GPS1 TOR1B SYT9 SYT8 SNAP91 AAK1 YWHAG STON1 RAB8A STON2 LMAN1 SLC2A8 SLC18A3 HSP90AA1 SGIP1 EPN2 VAMP4 STX5 FCHO1 YKT6 FCHO2 UBQLN1 REPS2 UBQLN2 REPS1 NECAP2 CSNK1D SYT11 DYNLL1 GJA1 UBA52 OPTN PAFAH1B1 DYNC1I2 AKT2 DCTN2 AKT3 DCTN3 UBB UBC AGTR1 RPS27A DYNC1H1 SAR1B COPS7B COPS7A BICD1 RHOBTB3 BICD2 GALNT2 PAFAH1B3 VPS36 PAFAH1B2 SFN SNF8 VPS25 DVL2 COPS3 COPS6 COPS5 ALB GJB2 GJB1 ARPC4 ARPC5 COPS8 TACR1 COPS4 ARPC2 ARPC3 COPS2 SNAP23 MAP1LC3B ACTR3 ACTR2 ARFGAP3 ARFGAP2 GRK2 GNS USP6NL TJP1 SCOC COL4A2 SYS1 COL4A1 GCC1 ZW10 RAB43 GOLGA1 ARFIP2 RINT1 CFTR KDELR2 COPB2 COPA ARL1 COPE USE1 CHRM2 RABEPK TMED3 TMED7 SCFD1 TMED9 ADRB2 NAA30 COPZ2 COPZ1 SPTBN1 NAA35 STAM NAA38 ARF5 NBAS TMF1 ANK3 STX18 COL3A1 STX10 ARFRP1 VPS51 VPS53 VPS52 BNIP1 EPS15L1 VPS54 COL7A1 ARCN1 MASP1 EPN1 COPG2 COPG1 PLIN3 RAB3A STAB2 SYT1 SPTAN1 LDLR MAN2A1 CD3G CTTN RHOQ YWHAQ HMGB1 YWHAH DYNC1I1 SEC23A SAA1 SSC5D STAB1 CD59 CD5L CD55 SEC24B TRIP10 SEC24A RAB9A RAB4A OCRL GALNT1 RAB9B EPGN AP4E1 ARRB1 CLINT1 M6PR AP1G1 VPS45 SYNJ2 SEC24D FTH1 AP1S2 SYNJ1 SEC24C AP1S1 AP1S3 RAB5A AP3S1 SH3D19 TPD52 AP1B1 PIK3C2A AP3B1 VAMP8 CD36 GAK DNAJC6 CALM1 HYOU1 FTL NAPA RAB5C BLOC1S4 TGOLN2 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 SNX9 SNX5 AP1M2 STAM2 TXNDC5 APOA1 AP1M1 TBC1D8B SNAPIN SORT1 DTNBP1 HIP1R PUM1 TPD52L1 AP4B1 IGF2R NECAP1 GOLGB1 YIPF6 CTSZ ACBD3 RAB14 CALR GRK3 WNT5A SYT2 FZD4 APP ALS2 CLTB TFG ARRB2 DAB2 CLTCL1 TF RAB5B AREG AVPR2 TRIP11 TMED2 SLC2A4 COG1 RAB6A BIN1 SNX18 RALGAPA2 RALGAPB C2CD5 MIA2 MIA3 TSC2 TSC1 AMPH HIP1 KIF28P PACSIN2 PACSIN3 SNAP29 PACSIN1 RAC1 ASPSCR1 TMEM115 KIF5C TBC1D1 KIF5B TBC1D4 KIF5A KIF21A KIF21B EREG KIFAP3 BTC KIF16B KIF20A KIF20B HBEGF KLC1 LNPEP KLC4 CBL KLC3 KLC2 KIF3B RACGAP1 KIF3C KIF18A MCFD2 KIF18B SERPINA1 KIF4B PPP6C KIF4A PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB TMED10 LMAN2L HBB STX17 USO1 KIF12 MAN2A2 KIF11 NAPG LMAN2 SEC31B KIF15 ANKRD28 SEC16B KIF19 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression EP300 TCF12 MYF6 MYCN TCF4 TNRC6C MYF5 RXRA MOV10 AGO3 TCF3 AGO4 SP1 AGO1 AGO2 RARA TNRC6A TNRC6B MYOG HELLS KLF16 SMAD4 SMAD3 MYOD1 TGFBR3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism GMPR NME2 NME3 AMPD1 HPRT1 NME4 AMPD2 AMPD3 NME1 CAD NME6 DCK AGXT2 TXN UMPS UCKL1 NT5C2 DHODH ADSS1 NT5C1A ADSS2 NT5C1B RRM1 RRM2 APRT GLRX ADA ADK DTYMK TXNRD1 DPYS PFAS ENTPD1 DNPH1 ENTPD2 ENTPD3 IMPDH1 ENTPD4 TYMS IMPDH2 ENTPD5 DCTD ENTPD6 ENTPD7 ENTPD8 TYMP ATIC CMPK1 NT5C CDA NT5E UPB1 XDH RRM2B PUDP NT5M DCTPP1 MAPDA ADPRM GDA ADSL SAMHD1 DPYD PAICS NUDT5 DGUOK UPP2 PPAT ITPA UPP1 CTPS2 UCK2 CTPS1 UCK1 TK2 TK1 AK1 NUDT16 NUDT15 AK2 NUDT13 GMPR2 AK4 AK5 GART AK6 PNP AK7 AK8 GUK1 AK9 GMPS DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA5 SEM1 UBE2M PSMA6 FBXW11 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 MAP3K14 NFKB2 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 CHUK CUL1 PSMD12 PSMD11 UBB PSMD14 RELB PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PSMD3 PSMB1 RELA PSMD1 UBA3 SKP1 ADRM1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres PIF1 SHQ1 PRIM2 PRIM1 ACD POLA1 TINF2 POLA2 RTEL1 TERF1 TERF2 POT1 TERF2IP LIG1 POLD1 DNA2 RFC5 RFC3 RFC4 RFC2 DKC1 NHP2 GAR1 FEN1 DSCC1 CHTF18 CHTF8 CTC1 STN1 NOP10 TEN1 PCNA WRN RPA1 RPA2 RPA3 TERT CDK2 CCNA2 CCNA1 RFC1 PPP6C PPP6R3 RUVBL2 RUVBL1 BLM WRAP53 POLD3 POLD4 POLD2 ANKRD28 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation IGLV1-44 IGKV3-15 IGKV3-11 LYN IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 PTPN6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 IGLC6 CD79B CD79A IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGHM IGKV2D-28 IGKV4-1 IGHV7-81 CD22 IGHD IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer TP53 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane CD274 JAK1 OST4 PDCD1LG2 OSTC TMEM258 STT3A STT3B B3GNT3 RPN2 MIB2 TUSC3 RPN1 DDOST MAGT1 PDCD1 DAD1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation FGF1 ANOS1 FGF4 TGFBR3 FGF9 GIPC1 FGF20 FGF23 FGF6 FGF2 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 GALK1 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers CALM1 SLC8A1 SLC8A2 SLC24A5 SLC24A1 SLC24A4 SLC8A3 SLC24A2 SLC24A3 SLC8B1 SRI TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis CHTF18 CHTF8 CTC1 STN1 TEN1 PRIM2 PRIM1 ACD POLA1 TINF2 POLA2 PCNA TERF1 WRN TERF2 POT1 TERF2IP LIG1 RPA1 RPA2 POLD1 DNA2 RPA3 RFC5 RFC3 RFC4 RFC2 RFC1 BLM POLD3 FEN1 POLD4 POLD2 DSCC1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH RFC5 RFC3 UBB RFC4 RFC2 UBC RFC1 RPS27A PCNA SPRTN UBA52 RPA1 NPLOC4 POLH VCP RPA2 UFD1 RCHY1 RPA3 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion VPS28 TSG101 UBB FURIN MVB12B UBC MVB12A RPS27A VPS37C VPS37D VPS37A VPS37B UBA52 UBAP1 NMT2 PPIA FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface MASP1 FCN1 FCN2 FCN3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling ATP5PD ATP5PB ATP5F1C ATP5MK ATP5MJ ATP5F1D ATP5MG ATP5F1E ATP5MF ATP5ME ATP5MC2 ATP5MC3 ATP5MC1 ATP5PO MT-ATP6 DMAC2L ATP5F1A MT-ATP8 ATP5F1B ATP5PF TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 TLR9 PELI1 LRRC14 TRAF6 USP14 IRF7 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 PPP2R1A BTRC RELA SKP1 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 TASL IRF5 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TLR8 PPP2R5D TLR7 MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 SLC15A4 MAPK3 MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing IL1A CASP1 IL1B GSDMD NFKB1 CTSG RELA NFKB2 IL18 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions CASK PRKCA ITGA2 TNC SDC1 ACTN1 SDC4 ITGB3 ITGB1 SDC2 ITGB5 SDC3 VTN THBS1 ITGA6 ITGAV TRAPPC4 TGFB1 ITGB4 FGF2 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane YWHAE CEP57 CETN2 CEP164 CCP110 B9D2 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL FBF1 YWHAG RAB8A TTBK2 NPHP1 CDK5RAP2 OFD1 NPHP4 HSP90AA1 MARK4 CEP135 RAB3IP TUBB CEP131 AHI1 HAUS4 CEP83 HAUS3 CEP89 CSNK1D C2CD3 HAUS6 HAUS5 RPGRIP1L CSNK1E TCTN3 TUBG1 TCTN2 DYNLL1 TCTN1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CC2D2A CEP63 MAPRE1 SFI1 IQCB1 PAFAH1B1 KIF24 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 TMEM216 DCTN3 HAUS8 PRKAR2B HAUS7 TMEM67 CEP70 CEP72 CEP192 SEPTIN2 MKS1 PCNT SCLT1 CEP76 RAB11A CLASP1 CEP78 PLK4 CEP162 DYNC1H1 B9D1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP97 CEP41 CEP43 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF VAV2 PIK3R2 VEGFA PIK3CB NRAS PIK3R1 CAV1 FYN MAPKAPK3 PRKCZ PIK3CA NCKAP1L ITGB3 CDH5 JUP PRR5 PAK1 PDPK1 CDC42 CTNNA1 ITGAV PAK3 MLST8 AHCYL1 NOS3 PLCG1 PRKACA NRP2 MTOR HSP90AA1 CALM1 CYBB CYBA PAK2 ABI2 ABI1 AKT2 KDR AKT3 NCF1 NCF2 NCF4 VEGFB VEGFC VEGFD ITPR1 ITPR2 ITPR3 SPHK1 CTNNB1 PTK2B NRP1 BRK1 HSPB1 NCK2 NCK1 AKT1 AXL MAPKAP1 PRKCD CTNND1 PRKCA MAPKAPK2 ROCK2 MAPK12 ROCK1 MAPK14 MAPK11 WASF1 WASF2 WASF3 PRKACG BAIAP2 PRKACB THEM4 RAC1 RHOA PGF SH2D2A FLT1 SHB RICTOR ELMO1 ELMO2 SHC2 DOCK1 CRK MAPK13 FLT4 PXN PTK2 BCAR1 CYFIP2 TRIB3 CYFIP1 NCKAP1 AAMP VAV3 HRAS PRKCB VAV1 RASA1 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC4A7 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport ABCG2 SLC22A2 SLC22A3 ABCB1 SLC22A1 SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS PTDSS2 PTDSS1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation VAV2 SYK NRAS MAP2K4 MAPK9 MAPK8 PLCG2 MAP2K7 MAPK10 PAK1 MAP3K1 PLCG1 GRAP2 LCP2 PAK2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 JUN RAC1 FOS MAPK1 MAPK3 SOS1 VAV3 HRAS VAV1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins NUP62 NUP37 PIAS4 NDC1 UBE2I SEC13 NUP133 NUP107 NUP188 NUP50 SUMO1 NUP54 SUMO2 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 TOPORS NUP153 NUP35 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling MKNK1 SPRY2 MAPK1 FRS2 BRAF MAPK3 FGF1 FGF4 FGF16 UBA52 FGF9 FGF18 FGF20 FGF23 CBL FGF6 FGF2 UBB UBC RPS27A PTPN11 PPP2R1A FGF7 FGF22 FGF3 FGF10 PPP2CA PPP2CB CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins DBNL CASP8 PLEC GSN VIM CASP3 GAS2 MAPT SPTAN1 CASP7 CASP6 ADD1 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases GAA UBB NHLRC1 GYG2 GYG1 UBC RPS27A SLC37A4 G6PC1 PPP1R3C EPM2A GYS2 UBA52 GYS1 G6PC3 GBE1 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production GNAT3 GNAZ PRKACG IL6 ADORA2B GNAI3 PRKACB ADCY9 PRKAR1B GNG3 PRKAR1A GNG2 GNG5 ADCY4 GNG4 GNG7 ADCY3 ADCY2 GNG8 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNG10 PRKAR2B GNG12 GNAS GNG11 GNG13 GNB2 GNAI1 GNAI2 GNB1 GNB4 GNB3 PRKX GNB5 PRKACA GNGT1 GNGT2 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse LYN MYL6 MYL9 NGEF FYN MYH9 RHOA ROCK2 YES1 ROCK1 MYH14 MYH11 MYL12B MYH10 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases CASP1 CASP2 CASP10 ATM TP53 TP63 APAF1 TP73 NLRC4 PIDD1 CASP6 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT2 TCP1 CCT8 CCT7 CCT6A CCT5 ACTB CCT4 CCT6B CCT3 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex SMARCD1 BCL7C SMARCD2 BCL7B SS18 SMARCD3 DPF2 ACTL6A SMARCA4 PHF10 SMARCC1 BCL11B SMARCC2 ARID1A BCL11A SMARCB1 SMARCE1 ACTB BCL7A RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling SNW1 EP300 MAMLD1 RUNX3 NOTCH1 MAML2 MAML1 RBPJ JAG1 MAML3 KAT2B KAT2A HES1 CREBBP TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling MCOLN1 ATP6V1H TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6V1B2 ATP6V0C ATP6V1B1 STEAP4 HFE ATP6V0D1 TFR2 ATP6V0D2 ATP6V1A TF ATP6V0E2 ATP6V1G3 STEAP3 ATP6V0A2 ATP6V0A4 ATP6V1D TFRC ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 ATP6AP1 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation GRIN1 CALM1 LRRC7 GRIN2A GRIN2C GRIN2D NRG1 DLG2 DLG3 GRIA1 GRIN2B GRIA2 SRC DLG4 CAMK2B CAMK2D DLG1 CAMK2A NRGN CAMK2G NEFL ACTN2 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E UBB UBA52 UBC RPS27A DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 GFPT1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events GPC1 CTSL GPC3 UVRAG GPC2 GPC5 GPC4 GPC6 SDC1 NRP1 CHMP3 AGRN CHMP6 CHMP7 MAP1LC3B CHMP4C HSPG2 CHMP4B HAVCR1 CHMP4A PIK3C3 BECN1 FURIN ZCRB1 VHL ACE2 SDC4 ISCU RB1 SDC2 VCP SDC3 CHMP2B DDX5 CHMP2A PIK3R4 TMPRSS2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors LRP10 BST1 LRP12 SLC19A3 PNPO SLC19A1 SLC19A2 MTHFR PDXK MTHFS THTPA PRSS3 NMRK2 NMRK1 PDSS2 PDSS1 NOS3 RFK LDLRAP1 LRAT SLC5A8 RBP4 RBP2 RBP1 HSP90AA1 RETSAT PDZD11 NMNAT3 NMNAT2 NMNAT1 CYB5R3 GPIHBP1 UBIAD1 NNMT QPRT SDC4 SDC2 SDC3 PARP16 PRSS1 PARP14 PARP10 MCCC2 SDC1 SLC5A6 PC BTD AMN PCCA HLCS NAXE MCCC1 PCCB ACACB ACACA CTRB2 CTRB1 HSPG2 AKT1 PARP6 PARP4 PARP9 FOLR2 MMACHC PARP8 NAXD SLC46A1 SLC25A51 NAMPT NADSYN1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 TTPA AGRN TCN2 TCN1 NADK2 APOB MOCS2 MOCS3 SLC25A19 CBLIF AKR1B10 GCHFR LRP1 MTHFD1 MTHFD2 LDLR RNLS TPK1 LRP2 MOCOS LRP8 SHMT2 SHMT1 RDH11 COQ8B COQ8A VKORC1L1 CYB5A MMAA MMAB DHFR SLC25A32 DHFR2 MMADHC GSTO2 GSTO1 CALM1 PRKG2 ABCD4 APOA2 SLC2A1 APOA1 SLC2A3 APOA4 NAPRT AOX1 TTR BCO2 CD38 ABCC1 BCO1 VKORC1 ALDH1L1 APOC3 ALDH1L2 HPDL GCH1 APOC2 AKR1C1 MTRR NUDT12 AKR1C3 AKR1C4 FLAD1 MTHFD2L NADK LPL ACO1 CD320 SLC22A13 SLC52A2 SLC52A3 SLC52A1 PLB1 MTR SPR ACP5 GPHN PTS STARD7 NT5E MTHFD1L LMBRD1 SLC23A2 SLC23A1 PNLIP PANK4 PANK2 PANK3 PANK1 MMUT IDH1 DCAKD COASY PPCDC SLC25A16 APOM NUDT8 CUBN VNN1 COQ9 VNN2 COQ7 PPCS APOE COQ6 FASN COQ5 ENPP2 COQ4 ENPP1 COQ3 SLC25A42 ENPP3 AASDHPPT COQ2 CLPS NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway UBE2N TAB3 TAB2 TAB1 TNFAIP3 CASP8 CASP1 CHUK CYLD MAPK13 MAP3K7 BIRC2 CARD9 BIRC3 TRAF6 CASP2 IKBKB IKBKG RIPK2 NOD1 NOD2 ITCH UBE2V1 CASP4 AAMP MAPK12 CASP9 MAP2K6 MAPK14 IRAK1 MAPK11 IRAK2 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB PDPK1 THEM4 TRIB3 AKT2 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines PSMA5 AZIN2 SEM1 PSMA6 PSMA3 PSMC5 AZIN1 PSMA4 PSMC6 PAOX PSMC3 AGMAT PSMA1 SRM PSMA2 PSMC4 PSMC1 PSMC2 OAZ1 OAZ2 OAZ3 ODC1 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMD8 PSMB7 SAT1 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 SMS AMD1 ADRM1 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption SLC2A2 RSC1A1 SLC2A5 ALPI PNLIP SI LCT PNLIPRP1 GUCY2C PNLIPRP2 MGAM CHIA AMY2A AMY1A AMY2B TREH AMY1B AMY1C GUCA2B CEL GUCA2A LIPF CHIT1 PIR PNLIPRP3 SLC5A1 CLPS G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase CDK2 CCNA2 CCNA1 E2F1 E2F3 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins ACAA1 HSD17B4 AGPS PHYH ACOX1 TYSND1 SCP2 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B YWHAE CEP57 CETN2 DYNLL2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG RAB8A CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB MCIDAS CEP131 HAUS4 CCDC78 HAUS3 RFX2 CSNK1D RFX3 HAUS6 HAUS5 CSNK1E CCNO TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 GRHL3 MAPRE1 GRHL2 SFI1 DEUP1 PAFAH1B1 SDCCAG8 GMNC DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 FOXJ1 NOTCH1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 DLL1 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 TNPO1 TP73 ARL13B IFT172 IFT52 E2F5 IFT57 DYNC2H1 IFT140 RPGRIP1L WDR35 IFT88 SMO KIF3A TTC21B INPP5E WDR19 IFT122 MKS1 B9D2 E2F4 CCT3 CCT2 TCP1 DYNC2I2 DYNC2I1 IFT70B IFT70A TRAF3IP1 CCT8 DYNLT2B KIF17 CCT5 DYNC2LI1 CCT4 IFT74 IFT56 DYNLT5 DYNLT2 IFT80 IFT20 IFT22 IFT43 IFT81 IFT27 TRIP11 DYNLRB2 DYNLRB1 IFT46 CLUAP1 IFT25 TFDP1 HDAC6 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 NPHP1 NPHP3 NPHP4 MARK4 RAB11FIP3 MYB BBS2 BBS1 RAB3IP BBIP1 AHI1 CEP83 CEP89 GRHL1 ARF4 C2CD3 PKD2 PKD1 TCTN3 TCTN2 TCTN1 KIFAP3 CNGA2 BBS9 CNGA4 BBS7 CC2D2A BBS5 BBS4 IQCB1 MKKS EXOC8 EXOC7 KIF24 SSTR3 BBS10 RP2 BBS12 TMEM216 EXOC4 EXOC3 KIF3B EXOC6 EXOC5 EXOC2 KIF3C CNGB1 EXOC1 ASAP1 TMEM67 PDE6D RHO SEPTIN2 GBF1 SCLT1 RAB11A ATAT1 TTC8 CEP162 B9D1 GMNN CEP97 RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events NAPEPLD OPN1LW OPN1SW LRAT RLBP1 OPN1MW RBP4 TTR RDH5 STRA6 RBP1 ABCA4 RDH12 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin TUBB2B TUBB2A TUBA3E TUBB6 TUBB3 TUBA3D TUBB1 TUBA3C TTLL10 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 TTLL1 AGBL3 TUBA1A AGBL2 TUBB8 TTLL13 TTLL11 TTLL12 TUBB8B TTLL9 TTLL8 TUBB4B TUBB4A TUBA1C TUBA1B SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease STAT3 ERLIN2 BCR NRAS PIK3R1 LRRFIP1 STAT1 FRS2 PIK3CA FGF1 ZMYM2 FGF4 FGF9 FGF20 SOS1 FGF23 CPSF6 GAB2 FGF6 TRIM24 FGF2 CUX1 FGFR1 GAB1 PLCG1 STAT5A STAT5B BAG4 FGFR1OP2 HRAS CEP43 MYO18A GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis POMC CYP17A1 HSD3B2 CYP11B2 CYP21A2 CYP11B1 HSD3B1 HSD11B1 SERPINA6 HSD11B2 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP9 F8 GGCX F9 GP1BA F10 GP1BB F11 GP5 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 FGF1 FGF4 FGF22 FGF9 PLCG1 FGF3 FGF10 FGF20 FGF23 FGF6 FGF2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition CDH2 CDH1 EDIL3 SERPINE1 PXDN ZEB1 ITGA2 PXN SOX2 STT3B GXYLT2 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events LRRC8D LRRC8A LRRC8B LRRC8E DMTN MMGT1 NIPA1 CTNS NIPA2 AZGP1 PIP ADD3 TUSC3 MAGT1 ADD1 RHCG RHBG RHAG MRS2 SLC66A1 ADD2 NIPAL4 ANKH NIPAL1 NIPAL2 NIPAL3 LRRC8C RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs ACSF3 HACD1 HSD17B12 ACSL6 TECRL ACSL5 ELOVL5 HSD17B3 ACSBG1 ACSL1 HACD3 HACD2 ACSBG2 HACD4 ELOVL1 TECR ELOVL4 ELOVL2 ELOVL3 SLC27A3 ACSL4 ACSL3 ELOVL6 ELOVL7 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs RAB5C TSC2 TSC1 RAB7A RAB8B RABGEF1 RAB33A RAB33B TBC1D10C OPTN TBC1D2 RABEP1 TBC1D3 TBC1D10A MAP1LC3B TBC1D10B TBC1D7 GABARAPL2 RAB7B ARF6 SYTL1 RABGAP1 RAB5B TBC1D20 GGA2 RAB35 GGA1 TBC1D24 TBC1D25 GGA3 ULK1 RAB11B RAB4A RAB11A GABARAP TBC1D13 TBC1D14 TBC1D17 RAB6B TBC1D15 TBC1D16 RAB5A RAB6A RAB8A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding KLB FGF19 FGFR4 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus PSEN2 TACC3 APH1A NEURL1B APH1B WWP2 MIB2 UBA52 ADAM10 PSENEN UBB EGF PSEN1 EGFR UBC DLL1 RPS27A NCSTN JAG1 YBX1 DLL4 NOTCH3 NEURL1 MIB1 JAG2 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOXL ACAA1 CRAT HSD17B4 EHHADH HACL1 SLC25A17 ACOT4 NUDT19 ACOX2 ABCD1 PECR ACOX3 ACOT8 DECR2 CROT PHYH AMACR SLC27A2 NUDT7 HAO2 ACBD5 ACBD4 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation OGDH GCSH AMT DLD GLDC DLST KGD4 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly MT-CO2 TMEM223 CMC1 TACO1 MT-CO3 COA5 COX6A1 COX6A2 SURF1 COX7A2L PET117 COX7B COX4I1 COX6B2 COX4I2 COX7C COX6B1 PET100 COX19 COXFA4 COX8A COX16 COX8C COX15 COX18 COX17 HIGD1A MT-CO1 COX5B COA3 RAB5IF COX5A COX11 COQ10B COX14 COA1 COQ10A TIMM21 TMEM177 COX7A2 HIGD2A COX7A1 COX6C COX20 SCO1 SMIM20 SCO2 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression EIF2S1 NFYA NFYB ASNS CXCL8 NFYC ATF3 HSPA5 EIF2AK3 CCL2 KHSRP DDIT3 DIS3 CEBPG ATF6 DCP2 PARN EXOSC7 HERPUD1 EXOSC6 EXOSC5 EXOSC4 ATF4 EXOSC9 CEBPB EXOSC8 EXOSC3 EXOSC2 IGFBP1 EXOSC1 EIF2S3 EIF2S2 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 CDC37 ERBIN ERBB2 HSP90AA1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins NUP62 PHC3 NUP37 NDC1 UBE2I SEC13 NUP133 NOP58 NUP107 NUP188 HNRNPK NUP50 SUMO1 NUP54 SUMO2 NUP210 HNRNPC NUP93 PCGF2 NUP205 POM121 BMI1 NUP214 NUP42 AAAS NUP160 RING1 POM121C NUP85 NUP43 TPR NUP88 RAE1 RNF2 RANBP2 NUP155 NUP153 CBX8 PHC2 PHC1 NUP35 CBX4 CBX2 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs H2AC14 H2BC21 H3-3B H2BC12L RAN H3C8 H2AC8 H2AC6 H2AC7 IPO8 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ AGO1 H2BC11 AGO2 TNRC6A H4C9 H3C15 POLR2A POLR2B POLR2C POLR2D H2BC9 H2BC8 POLR2G H2BC5 POLR2I H2BC3 H2AC20 POLR2J H2BC1 H2AX POLR2E POLR2F POLR2H H2AC19 POLR2K POLR2L H2BC26 H2AB1 H2AZ2 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism HYKK CRYM ALDH7A1 DHTKD1 AASS GCDH DLD PIPOX PHYKPL DLST SLC25A21 AADAT TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex UBB UBA52 UBC TAB3 MAP3K7 TAB2 TLR3 TAB1 RPS27A TRAF6 TICAM1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation CASP3 H1-1 H1-0 DFFB H1-3 DFFA H1-2 HMGB2 H1-5 H1-4 KPNA1 HMGB1 KPNB1 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction H2AC14 H2BC12L FKBP6 PRDM1 ACD TINF2 PDPN EOMES TERF1 NANOS3 TERF2 RAD51C ADAM2 POT1 ACR TERF2IP NANOG IZUMO3 OVGP1 IZUMO2 IZUMO4 IZUMO1 SPAM1 CBFA2T2 ZP1 ZP3 ZP2 ZP4 ADAM21 ADAM20 ADAM30 H4C9 H2AC20 TFAP2C RBBP8 H2AX SYCP2 SYCP1 SPO11 SYNE2 SYNE1 RAD50 SUN1 TEX12 TEX15 SMC1B MSH4 MSH5 H3-3B DMC1 SYCE3 PSMC3IP SYCE2 H3C8 SYCE1 MND1 HSPA2 REC8 LMNB1 MLH3 STAG3 TET2 SYCP3 SMC3 RAD21 STAG1 STAG2 SMC1A H2AJ CXCR4 H3C15 H2BC9 H2BC8 H2BC5 H2BC3 PRDM9 BRCA2 H2BC1 FIRRM FIGNL1 SOX17 H2AB1 SUN2 H2AC8 CD9 H2AC6 H2AC7 UBE2I B4GALT1 HVCN1 ATM ATR CATSPER1 CATSPER3 KCNU1 CATSPER2 CATSPERB CATSPER4 CATSPERD BRCA1 H2BC26 CATSPERG POU5F1 RAD51 H2BC21 TOP3A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 RPA1 H2BC11 RPA2 MLH1 RPA3 CDK4 CDK2 MRE11 H3-4 NBN BLM BMP4 H2AC19 H2AZ2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling SEMA3A CRMP1 PLXNA1 PLXNA2 PLXNA3 FYN CDK5 FES GSK3B NRP1 PLXNA4 DPYSL4 DPYSL5 CDK5R1 DPYSL2 DPYSL3 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine GLYATL3 GLYATL2 GLYATL1 GLYAT ACSM2A ACSM5 ACSM4 ACSM2B ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG DGAT2 DGAT1 PNPLA2 AWAT2 DGAT2L6 MGLL PNPLA3 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) CP SLC40A1 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding CALM1 NCALD GNG3 GNG2 GNG5 DLG1 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 GNG13 DLG3 GNB2 GNB1 GRIK5 DLG4 GNB4 GRIK3 GNB3 GRIK4 GRIK1 PLCB3 GNB5 GRIK2 GNGT1 PLCB1 PLCB2 GNGT2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling SRC WWP1 UBB NEDD4 UBA52 UBC ITCH RPS27A DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction NAPEPLD OPN1LW OPN1SW LRAT RLBP1 OPN1MW RBP4 TTR RDH5 STRA6 RBP1 ABCA4 RDH12 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins OPN1MW RGR OPN1LW RRH OPN3 OPN5 RHO OPN1SW OPN4 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SKP2 PTTG1 AURKB NEK2 BTRC ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC14A UBA52 CUL1 AURKA PSMD12 CCNB1 BUB1B PSMD11 UBB CDC20 FBXO5 PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 RB1 PSMB3 PLK1 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 TLR9 PELI1 LRRC14 TRAF6 USP14 IRF7 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 PPP2R1A BTRC RELA SKP1 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 PPP2R5D TLR7 MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 MAPK3 MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib CDC37 ERBIN ERBB2 HSP90AA1 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein BID BAK1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex UBB UBA52 UBC TAB3 MAP3K7 TAB2 IRAK2 TAB1 RPS27A TRAF6 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity A2M C1QBP PLAUR KLKB1 SERPING1 HRG KNG1 F12 KRT1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors AKT1 TP53 ZNF385A TP53BP2 BANP PHF20 TP63 TP73 PPP1R13B POU4F1 POU4F2 AKT2 PPP1R13L AKT3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK ARHGEF19 VAV2 ARHGEF18 ARHGEF9 ARHGEF3 TIAM2 ARHGEF4 ARHGEF1 NGEF ARHGEF2 ARHGEF7 ARHGEF5 MAPK8 ABR ARHGEF6 GNA13 RASGRF2 AATF MAGED1 PLEKHG2 NGF SOS2 TIAM1 ARHGEF33 FGD1 ARHGEF35 FGD2 ARHGEF37 ARHGEF38 FGD3 FGD4 ARHGEF40 PLEKHG5 RAC1 MCF2 ARHGEF26 SOS1 KALRN ECT2 ARHGEF39 NET1 NGFR TRIO AKAP13 ITSN1 ARHGEF10L MCF2L PREX1 OBSCN ARHGEF11 VAV3 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 BCL2L11 ARHGEF16 VAV1 BAD GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking GJB2 GJB1 CLTB GJC1 GJC2 GJA3 MYO6 GJA10 GJA5 DAB2 GJA1 CLTCL1 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CLTC CLTA DNM1 DNM2 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER CUL4A ERCC3 POLE4 ERCC4 ERCC2 POLE2 ERCC1 POLE3 ERCC5 DDB2 CUL4B PCNA RBX1 PARP1 UBA52 RPA1 RPA2 POLD1 RPA3 RFC5 UBB RFC3 RFC4 POLK RFC2 UBC POLE RFC1 PARP2 RPS27A GTF2H1 GTF2H2 CHD1L GTF2H3 GTF2H4 DDB1 GTF2H5 XPA POLD3 POLD4 POLD2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints CDC6 DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 KIF2A KIF2C KIF2B UBE2V2 CLSPN CENPE WEE1 NUF2 NUDC YWHAE DYNLL2 INCENP PPP2R1A BTRC ANAPC15 ANAPC16 CENPA UBE2D1 ANAPC10 CENPC YWHAG ANAPC11 SKP1 CDC23 CDC26 CDC27 ANAPC7 FBXW11 UBE2C CDKN2A CENPT UBE2E1 CENPU UBE2S BRCC3 CDC16 ANAPC4 CSNK1E BABAM1 ANAPC5 BABAM2 ANAPC1 UIMC1 DYNLL1 ANAPC2 CKAP5 ABRAXAS1 CENPF RNF8 CENPH MAPRE1 CENPI UBA52 TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CUL1 CENPP CENPQ CCNB2 CENPS PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 CLASP1 PSMB7 PSMB4 PSMD6 DYNC1H1 PSMB5 PSMD7 PSMB2 NDE1 PLK1 PSMB3 PSMD2 CLIP1 PSMD3 PSMB1 PSMD1 MAD1L1 CDK1 ADRM1 SFN PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 CDC25A PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 NDC80 MDC1 RPS27 PSMC2 KAT5 CHEK2 CHEK1 HUS1 YWHAB DNA2 RHNO1 XPO1 SPDL1 PCBP4 YWHAZ ATRIP BARD1 PLK3 RAD17 ATM NSL1 ATR CDKN1A MAPK14 BRCA1 MAPK11 CDC45 MCM7 MCM8 MCM3 RMI2 MCM4 NEK11 MCM5 MCM6 RMI1 MCM2 TOP3A RBX1 WRN KNL1 ZW10 RPA1 RPA2 RPA3 DSN1 RAD1 CSNK1A1 RCC2 BUB1B CDC20 ZWINT CCNA2 MRE11 CCNA1 BUB3 AHCTF1 MAD2L1 NBN CDC25C BLM NDEL1 H2BC12L UBE2N NUP107 MDM2 MIS12 MDM4 PPP1CC RAD9B YWHAQ RAD9A YWHAH EXO1 DYNC1I1 H4C9 TOPBP1 ZNF385A RFC5 RFC3 RFC4 RFC2 NUP160 NUP85 BIRC5 B9D2 SPC24 AURKB SPC25 RBBP8 H2AX ERCC6L PHF20 CDC7 ZWILCH RAD50 KNTC1 SEC13 SGO1 SGO2 GTSE1 NUP133 RANGAP1 PMF1 CCNE2 CCNE1 NSD2 H2BC9 H2BC8 H2BC5 NUP43 H2BC3 H2BC1 RANBP2 TP53BP1 NUP37 PIAS4 RNF168 ITGB3BP MCM10 COP1 DBF4 BUB1 CLASP2 PKMYT1 TP53 GSK3B PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA H2BC26 PPP2CB PPP2R1B H2BC21 PPP2R5E HERC2 CDKN1B H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CDK2 H3-4 KIF18A BRIP1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 PROC F5 PROS1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription H2AC14 ERCC3 H2BC12L RRN3 H2AC8 ERCC2 H2AC6 ERCC6 H2AC7 H4C9 CAVIN1 CBX3 CDK7 H2AC20 MNAT1 H2AX CHD4 CHD3 PHF6 H2BC26 H2BC21 H3-3B H3C8 UBTF TBP H2BC17 H2BC12 H2BC13 H2BC14 MAPK3 KAT2B H2BC15 KAT2A H2AJ POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 H3C15 MBD3 HDAC1 H2BC9 H2BC8 TAF1D H2BC5 MTA1 TAF1B H2BC3 RBBP4 MBD2 TAF1C H2BC1 GTF2H1 GTF2H2 GTF2H3 TAF1A GTF2H4 POLR2E GTF2H5 POLR2F GATAD2B GATAD2A POLR2H RBBP7 CCNH MTA2 EHMT2 MTA3 H2AC19 POLR2K POLR2L H2AB1 H2AZ2 TTF1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors ADRB2 ADRA2B ADRA1D ADRA1B ADRB3 ADRA1A ADRA2C ADRA2A ADRB1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer CUL1 NOTCH1 SKP1 RBX1 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway CALM1 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 KPNA2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A PRKCD PRKAR2B PRKCA CAMKK1 CAMKK2 NBEA CAMK2B CAMK2D PRKX CAMK2A PRKACA PRKCG PDE1C CAMK2G GRK2 PDE1B PDE1A PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion CORO1A HGS UBB VPS33B RAB7A UBA52 UBC RAB5A RPS27A COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF13B KIF1C KIF1B KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 SEC22B KIF9 KIFC2 KIF2A KIFC1 NSF KIF2C KIF2B CENPE KDELR1 KIF26A KIF26B ARFGAP3 ARFGAP2 TMED2 COPB1 NAPA KIF28P ARF4 KIF5C KIF5B KIF5A KIF21A KIF21B KIFAP3 KIF16B ZW10 KIF20A KIF20B RINT1 KDELR2 COPB2 COPA KLC1 COPE USE1 ARFGAP1 TMED3 KLC4 TMED7 KLC3 TMED9 RAB1A KLC2 KIF3A KIF3B COPZ2 RAB1B RACGAP1 COPZ1 KIF3C ARF5 NBAS SURF4 ARF3 STX18 ARF1 KDELR3 KIF18A GBF1 KIF18B KIF4B BNIP1 KIF4A ARCN1 COPG2 COPG1 NAPB TMED10 KIF12 KIF11 NAPG KIF15 KIF19 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MEF2A ALCAM SCN11A MEF2C SCN10A AGAP2 L1CAM LYPLA2 DSCAML1 SHC3 RAP1GAP SPI1 DAB1 PTPRA DCT CNTNAP1 THRAP3 SPTB ITGA9 NTN4 ABLIM1 ABLIM2 ABLIM3 NFASC EPHB6 RPS6KA4 EPHB2 EPHB1 FAM120B EPHB4 KRTAP27-1 SCN1B KRTAP5-10 SCN1A KRTAP5-11 EPHB3 KRTAP16-1 EPHA5 FLI1 EPHA7 KRTAP25-1 EPHA6 KRTAP2-4 EPHA8 KRTAP2-3 ANK2 KRTAP2-2 SHTN1 KRTAP2-1 KCNQ2 KRTAP4-4 KCNQ3 KRTAP4-3 EPHA1 MBP EPHA3 GRIN2B KRTAP4-2 SPTBN4 KRTAP4-1 SPTBN5 ZNF423 EPHA10 KRTAP4-9 MYL12A KRTAP4-8 SCN3B KRTAP4-7 SCN3A KRTAP4-6 SCN2A KRTAP4-5 CD24 ADGRV1 SCN2B KRTAP29-1 NRP2 KRTAP6-2 VLDLR KRTAP6-1 CAP1 KRTAP6-3 RGMB KRTAP8-1 GFRA3 RGMA MPZ RELN KRTAP23-1 HEY1 CAP2 ADGRG6 SCN9A KRTAP12-1 HEY2 KRTAP12-3 NRCAM KRTAP12-2 DSCAM DOK4 KRTAP12-4 DOK5 KRTAP10-1 DOK6 KRTAP21-2 SCN8A KRTAP21-3 HMGCR EFNA5 KRTAP10-3 EFNA4 SPTA1 KRTAP10-2 KRTAP10-5 EFNB2 KRTAP10-4 PI3 EFNB1 KRTAP10-7 EFNB3 KRTAP10-6 EFNA1 KRTAP10-9 EFNA3 KRTAP10-8 EFNA2 BCL2A1 KRTAP21-1 HJV SCN5A KRTAP17-1 KRTAP4-11 GAP43 KRTAP26-1 DCX SCN4A KRTAP1-5 SCN4B KRTAP1-4 SHANK3 KRTAP1-3 LAMA1 KRTAP1-1 SCN7A KRTAP15-1 PDLIM7 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 MESP2 KRTAP5-5 PSMD12 KRTAP5-4 PSMD11 KRTAP19-2 NOTCH1 KRTAP19-1 PSMD14 KRTAP19-4 PSMD13 KRTAP19-3 KRTAP19-6 LEF1 RBPJ KRTAP19-5 KRTAP19-8 DRP2 DLL1 RPLP1 PSMA7 KRTAP19-7 RPLP0 CEBPE DLL3 PSMB6 GFI1 PSMD8 KRT4 LFNG KRT3 PSMB7 KRT2 PSMB4 KRT8 PSMD6 EBF2 RPLP2 PSMB5 KRT7 PSMD7 KRT5 PSMB2 KRT9 PSMB3 UTRN KRTAP20-1 PSMD2 KRTAP20-2 PSMD3 VTN KRTAP10-10 PSMB1 KRTAP10-11 PSMD1 KRTAP10-12 HES7 ELOVL3 KRT33B EPHA4 KRT33A MSGN1 GDF1 BMP7 ADRM1 KRT24 TBX6 KRT23 PSMA5 KRT20 LAMC3 KRT28 SEM1 PSMA6 KRT27 PSMA3 KRT26 PSMC5 KRT25 PSMA4 PRX PSMC6 KRTAP9-7 RIPPLY2 KRTAP9-6 PSMC3 KRTAP9-4 PSMA1 KRTAP9-3 PSMA2 KRTAP9-2 PSMC4 KRTAP9-1 KARS1 PSMC1 KRT35 UCP1 PSMC2 KRT34 KRT32 CTNNB1 LAMA2 KRT31 LAMA4 KRTAP9-9 KRTAP9-8 SH3KBP1 KRT39 LAMB2 KRT38 KRT37 KRT36 KRT13 FOXO4 KRT12 FOXO3 KRT10 FOXO1 KRT19 KRT18 YWHAB KRT17 KRT16 KRT15 KRT14 XPO1 KRTAP24-1 KRT6C AKT1 KRT6B KRT6A KRT71 KRTAP13-2 KRTAP13-1 PRKCA KRTAP13-4 YWHAZ KRTAP13-3 KRT79 KRT78 PABPC1 KRT77 KRT76 MARK3 RPL22L1 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP22-1 KRTAP11-1 KRT82 KRT81 KRT80 KRT86 KRT85 KRT84 HSPA8 NOTO PMP22 MAPK14 MAPK11 HAND2 ITGA5 EIF4G1 PRKACG CNTN1 PRKACB TBX5 RBX1 NUMB TRIM33 PIK3CD PRKAR2A TGFA DAG1 WWTR1 YES1 HNF4G YAP1 HRAS RASA1 NRAS IHH CCND3 IARS1 TCF3 LDB1 LIG1 RPL23A SERPINE1 NKX2-5 STX1A PIK3R3 RARG TEAD1 TEAD2 ELOB TEAD4 ELOC TCF12 TAL1 RARB NCBP1 RPL27A NCBP2 WASL PCGF2 CXCR4 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I ITGA2B POLR2J EBF1 NCAN PLXNA4 CHD9 CLTC CLTA ZNF521 AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 DARS1 KLF4 RAB27A SOX9 INS RPL26L1 RPL4 ROBO2 ITGB1 RPL5 RPL30 RET FOXC2 RPL3 FOXC1 RPL32 SIX1 GATA3 RPL31 RPL34 HOXD11 PCDH19 HOXC11 RPL8 FGF2 WFDC2 HOXA11 RPL6 PLAC8 RPL7 SMAD2 WNT11 SALL1 SMAD1 MECOM SMAD4 RPL36 SMAD3 SIX2 HNF4A SLIT2 RPL35 HOXA6 WNT4 IRX1 RPL38 IRX2 EMX2 JAG1 EYA1 RPL37 OSR1 RPL39 WNT9B GFRA1 HNF1B NPNT POU3F3 PAX2 BMP4 RPL21 GREM1 RPL23 GDNF RPL22 PAX8 WT1 MED8 HES1 MED9 LHX1 ITGA8 HOXB4 ID4 PIK3R2 MC4R RPL24 HINT1 TFEB PIK3CB RPL27 EDNRB TNFSF11 PIK3R1 FOXD3 RPL26 RPL29 EDN1 RPL28 EDN3 TFE3 MITF MYC SOX10 POU3F2 MC3R TFEC FRS2 ALX3 TBX3 PIK3CA MC1R ID1 ITGB3 MC5R TNRC6C MOV10 AGO3 CDK19 AGO4 RPL41 AGO1 AGO2 RPL3L TNRC6A TNRC6B TGFB1 CCND1 CBFB RUNX3 RUNX1 TFAP2A TFAP2B TFAP2C CEBPB SEMA5A RELA ASAH1 RPL10 RPL12 RPL11 TCF7L2 RPL14 CDKN2A RPL13 NFKB1 RPL15 RPL18 RPL17 RPL19 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 AKT2 AKT3 RPS11 RPS10 RPS13 RPS12 CACNB2 CACNB3 RPS4Y2 SDC2 RPS4Y1 SRPK1 RPS26 ATP6V1E1 RPS25 RPS28 ATP6V1G1 RPS27 ATP6V0E1 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 NRP1 GPR143 RPL37A ATP6V0D1 ATP6V1A TYRP1 RPL36A RPL35A ATP6V1C1 RPS27L RPS15A GPC1 PTGDS RPS3 RPS2 ATP6V0B ATP6V1B2 ATP6V0C FAU AGRN RPS9 RPS7 RPS8 RPS5 LEP RPS6 RPSA CDON ANK3 RPL39L CIDEA SOX1 ZIC2 OTX2 POU3F1 QARS1 FYN STT3B WNT10B HSP90AB1 RPS4X YWHAH RPS3A AKAP5 SCD5 RANBP9 PTPN11 ZEB2 ZEB1 COX7A1 MEF2D TREM2 TYROBP SLC2A2 MYRIP MARS1 IRS2 PRL WNT1 POMC CLTB PPP3CB CLTCL1 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D ITGA1 SEMA7A SEMA3A GAB1 CRMP1 MET SEMA3E RRAS PLXNA2 AREG PLXNA3 MAML2 SEMA4A CD72 MAML1 DMRT1 SRY SEMA4D PTPRC FES PLXNB3 NTN3 TFDP1 ADIRF CDH4 TFDP2 SLC2A4 LGI1 ZNF638 CDH2 LGI4 ZNF467 BNIP2 LGI3 MAML3 KLF5 CTNNA2 LGI2 NEO1 ADAM11 FGF7 NOTCH2 ADAM22 SPAG9 MEF2B STX1B MAPK12 CACNG8 ADAM23 CDH15 E2F1 FGF10 CACNB1 CACNG2 CACNB4 CACNG3 TCF7L1 CACNG4 WNT3A DLX5 JUN PAX3 POU5F1 SOX2 PAX7 SNW1 ZIC1 MAMLD1 MYB MSX1 MAPK7 ARHGAP35 RAC1 RHOA DOK1 ZFPM2 GATA6 DOCK1 GATA4 SIAH2 SIAH1 GATA2 EPAS1 PXN CDK4 CDK2 KIF4B KIF4A EIF4A3 CASC3 MAGOH CDC42 CUL2 RBM8A UPF3B MAGOHB RNPS1 KRT1 TRPM1 FOXF1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 ATP6V1H PITPNA CFL1 STAT4 PAK2 IL12RB2 MSN IFNG CTCF PRKCQ VASP ENAH LYN CDC25B MYH9 KAT5 DLG1 CSF3R EZR MYO5A MYO10 TCHH PCSK6 TGM1 LCE1A CASP14 LCE1B RDX CDKN1A TIAM1 LCE5A LIPJ LIPN CDK5R1 LIPM BRCA1 GCK PRSS8 LIPK TGM5 NAB1 RPTN NAB2 CELA2A SPINK6 SPINK5 TNKS1BP1 KAZN LCE1E LCE1F LCE1C MCM5 CNOT6L EGR2 LCE1D LCE2B MCM2 LCE2C FOS LCE2A LCE6A MAP2K1 PKP2 MAP2K2 PKP1 LORICRIN PKP3 MAPK1 SPINK9 DSG3 PERP DSG4 MAPK3 DSC1 DSC2 IVL FGF4 DSC3 FLG FGF9 HOXC4 SPRR2E SPRR2F SOS1 SPTBN2 SPRR3 CSTA SPRR2G KLK5 KLK8 PPL EVPL LCE2D LCE3C LCE3D LCE3A LCE3B LELP1 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK13 KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B MAP2K6 LARS1 CNOT10 CNOT4 CNOT6 CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 PIP5K1C UNC5A CNOT8 UNC5B CNOT9 DCC UNC5C UNC5D NTN1 CEACAM1 MED19 MED15 MED18 MED11 ST8SIA4 NELL2 SLIT3 MED26 EIF4A2 HDAC10 BTG4 MED29 EIF4A1 TUT7 MED28 TUT4 MED22 DUX4 MED25 PABPN1L TPRXL DUXA DUXB MED21 DIS3L2 PRM2 PRM1 STPG4 DICER1 PRDM16 METTL23 DPPA4 DPPA3 DPPA2 ZFP36L2 LEUTX HIRA PABPN1 EIF4E EIF4B PAIP1 NPM2 KDM4E TPRX1 AICDA H1-8 TPRX2 ZSCAN4 RPS6KA6 CNTN6 CHL1 ITGA2 ITGA10 ANK1 DLG3 TPST2 GMPR HDAC4 UBE2I KDM5A KDM5B NR5A1 KDM6B RXRA SUMO1 RARA PPARG PPARA HDAC8 GRIN1 TP53 ONECUT3 ONECUT1 NEUROD1 NKX6-1 NKX2-2 PDX1 PAX4 PAX6 HNF1A MAFA RFX6 IAPP INSM1 PTF1A FOXA3 CSNK2A1 NEUROG3 FOXA2 CSNK2A2 ROCK1 CSNK2B DSP HOXA3 HOXA1 PKNOX1 HOXA4 PIAS2 HOXB3 HOXB2 HOXB1 HOXD1 MEIS1 DSG1 MAFB PKP4 HOXD4 HOXD3 EPHA2 ZNF335 BIRC7 KIT TRIO ITSN1 PCK1 CACNA1H CER1 FOXH1 MED13L AIMP1 PSEN2 MYL6 AIMP2 APH1A APH1B MYL9 NGEF EPRS1 DRAP1 HIF3A MYF6 TCF4 MYF5 JUP ITGAV AMH MYOG ARPC1B ARPC1A PSENEN NOG SREBF2 EEF1E1 EGF MYOD1 ERBB2 PLCG1 EGFR YWHAE ACVR1B PRDM14 CRIPTO ACVR1C ACVR2B LIN28A ZIC3 ACVR2A ZSCAN10 PRKACA YWHAG HSP90AA1 FARP2 NR2F2 FOXA1 GXYLT2 SYTL2 PMEL EDIL3 CXCL12 MLANA TBX2 MLPH UBA52 AJUBA USF1 SHC1 DOK2 CCNB1 PLXND1 UBB CACNA1D CACNA1C UBC RPS27A FGF8 CLASP1 SOX17 PLK1 FLRT3 STAT3 PBX1 BCL2 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 MAG ARPC5 CAPNS1 ARPC2 ARPC3 CDH1 PLXNB1 CAPN1 GRB10 MSI1 HOXA2 ISL1 ADAM10 TGS1 COL4A5 NCK2 GSPT2 GSPT1 NCK1 UPF3A LHX3 ACTR3 LHX2 LHX4 ACTR2 LHX9 USP33 ROBO1 UPF2 ETF1 PSEN1 ZSWIM8 SLIT1 DSG2 EVL NCSTN SOS2 CARM1 SRC ROCK2 SRF COL9A1 COL9A3 COL9A2 LAMC2 LAMC1 COL4A2 MMP2 COL4A1 COL4A4 COL6A2 MMP9 COL4A3 PXDN PFN1 COL6A1 PFN2 GRB7 COL6A3 COL6A6 KALRN COL6A5 MYL12B LAMA5 LAMA3 SPTBN1 FURIN PTK2 LAMB3 LAMB1 SPTAN1 SMARCB1 GIT1 VAV3 H2AC19 CCNC RHOC ACTB H2AC14 VAV2 RHOB H2BC12L DPF1 DPF2 DPF3 MED1 SMARCC1 SMARCC2 ARHGEF7 EOMES MED4 TBXT TBPL2 MED6 MED7 GSC RPL10L NANOG RPL10A MIXL1 PAXIP1 PAK1 SNAI1 RARS1 PPARGC1A PPARGC1B SNAI2 CTNNA1 GAB2 PAK6 CREBBP PAK3 PAK5 H4C9 PAK4 SS18L1 SALL4 SMARCA2 MYO9B SMARCA4 H2AC20 SDCBP EZH2 H2AX ASH2L ARHGAP39 MED16 ACTG1 MED17 MED12 MED14 MED13 MED10 FN1 CD36 H3-3B SHH NCOA1 NCOA2 H3C8 SS18 NCOA6 NCOA3 ACTL6A MED27 RPL13A SIRT1 ARHGEF28 MED23 NCOR2 KAT2B KAT2A H2AJ MED24 NCOR1 TET3 MED20 MYH14 MYH11 ANGPTL4 MYH10 PLIN1 H3C15 TBL1X CYP51A1 MBD3 SUZ12 LEFTY2 H2BC9 H2BC8 H2BC5 H2BC3 DIAPH1 H2BC1 DLG4 GATAD2B GATAD2A RND1 FABP4 IL6R ARHGEF11 RPL18A RPL36AL ARHGEF12 H2AB1 EP300 LEFTY1 CRIPTO3 MEN1 CFC1 NODAL H2AC8 HNRNPU DAND5 MESP1 H2AC6 TBX20 H2AC7 ADIPOQ SMYD1 TBX1 MYOCD HAND1 TBL1XR1 KMT2D KMT2A KMT2C HELZ2 LPL CLASP2 MED30 MED31 TYR LIMK2 LIMK1 ABL1 HDAC11 BMI1 TNF ETS1 YY1 IL4R CDK8 KLF13 RING1 IL13 CDK5 MAF IRF4 HDAC5 CEBPD SATB1 HDAC9 RNF2 HDAC6 HDAC7 GSK3B TBX21 CCL3 STAT6 STAT5A DPY30 CBX8 STAT5B CHD4 CHD3 PHC2 PAGR1 CBX6 PHC1 H2BC26 POU2F1 TLN1 CBX4 BCL7A CBX2 NFATC2 SIN3A NFATC1 H2BC21 POU2F2 BCL7C PHC3 BCL7B BATF IL4 IL5 WDR5 KDM6A EED ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CACNA1G CACNA1I RPL9P9 NRTN CEBPA NCAM1 CACNA1S SMARCD1 PRNP HDAC2 PSPN FGFR1 SMARCD2 GFRA2 HDAC3 GFRA4 ARTN TCF7 SMARCD3 UHRF1 CNTN2 TERT HDAC1 MTA1 RBBP4 RBBP5 POLR2E POLR2F POLR2H RBBP7 DHH MTA2 MTA3 CSF1 POLR2K POLR2L SMARCE1 H2AZ2 ST8SIA2 DEK SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease STAT3 LYN PIK3R2 NRAS PIK3R1 JAK2 FYN LCK STAT1 PIK3CA STAT5A YES1 STAT5B PIK3R3 SOS1 KIT HRAS FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 FGF23 FGF6 FGF2 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis CCND3 MED1 MED4 MED6 MED7 WNT10B THRAP3 CDK19 PPARGC1A PPARGC1B CREBBP TGFB1 FAM120B SREBF2 MED19 MED15 MED18 ZNF423 MED11 CEBPB COX7A1 MED16 MED17 RELA MED12 MED14 MED13 MED26 MED10 CD36 MED29 MED28 MED22 NCOA1 NCOA2 MED25 NR2F2 NFKB1 NCOA6 MED21 NCOA3 PRDM16 MED27 MED23 NCOR2 MED24 NCOR1 MED20 ANGPTL4 PLIN1 TBL1X MBD3 EBF2 GATAD2B GATAD2A FABP4 EBF1 ELOVL3 BMP7 EP300 WNT1 HNRNPU ADIPOQ UCP1 TBL1XR1 HELZ2 RXRA LPL MED30 MED31 PPARG PPARA TGS1 TNF CDK8 CHD9 CEBPD ADIRF SLC2A4 ZNF638 CARM1 ZNF467 KLF5 CHD4 CHD3 KLF4 EGR2 CEBPA LEP HDAC2 SMAD1 HDAC3 SMAD4 CDK4 SMARCD3 HDAC1 MTA1 CIDEA RBBP4 PCK1 RBBP7 MTA2 MTA3 MED8 CCNC MED9 MED13L GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport CAPZB KIF13B DYNC1LI1 AGPAT3 DYNC1LI2 KIF1C KIF1B KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIFC2 KIF2A KIFC1 KIF2C KIF2B DYNC1I1 CENPE KDELR1 KIF26A CAPZA1 KIF26B CAPZA2 DYNLL2 GALNT1 ACTR1A COPB1 NAPA DYNLL1 DCTN1 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 SURF4 ARF3 ARF1 DYNC1H1 BICD1 BICD2 GALNT2 PAFAH1B3 PAFAH1B2 SEC22B NSF ARFGAP3 ARFGAP2 TMED2 RAB6B RAB6A KIF28P ARF4 KIF5C KIF5B PLA2G6 KIF5A KIF21A KIF21B KIFAP3 KIF16B ZW10 KIF20A KIF20B RINT1 KDELR2 COPB2 COPA KLC1 COPE USE1 ARFGAP1 KLC4 TMED3 KLC3 TMED7 KLC2 KIF3A TMED9 RAB1A KIF3B RACGAP1 COPZ2 RAB1B COPZ1 KIF3C ARF5 NBAS STX18 KDELR3 KIF18A CAPZA3 GBF1 ACTR10 KIF18B KIF4B KIF4A BNIP1 PLA2G4A ARCN1 RAB18 RAB3GAP2 COPG2 COPG1 RAB3GAP1 NAPB TMED10 DCTN6 KIF12 DCTN5 KIF11 DCTN4 NAPG KIF15 KIF19 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis AKR1B15 HSD17B1 HSD17B11 HSD17B2 HSD17B14 CYP19A1 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis PDE2A IRAG1 PDE11A PDE10A KCNMB1 FGR KCNMA1 LRP8 KCNMB2 KCNMB3 KCNMB4 NOS1 PDE5A PDE9A PTGIR P2RX7 GNG3 PTPN6 GNG2 GNG5 GNG4 GNG7 GNG8 NOS3 PECAM1 PTPN11 PPP2R1A P2RX4 TRPC7 SLC8A3 PPP2R5B ATP2B4 ATP2A3 PPP2R5A ATP2A2 TRPC6 PPP2R5D TRPC3 PPP2R5C ATP2B3 MAPK14 PAFAH2 ATP2A1 PPP2CA PPP2CB ATP2B2 ATP2B1 SRI CALM1 SLC8A1 PPP2R1B PRKG2 NOS2 SLC8A2 PPP2R5E P2RX6 P2RX5 STIM1 P2RX3 P2RX2 P2RX1 ORAI2 ORAI1 APOB GNG10 GNG12 GNAS GNG11 GNG13 GNB2 ITPR1 GNB1 PLA2G4A ITPR2 GNB4 ITPR3 GNB3 GNB5 GNGT1 GUCY1A2 GUCY1A1 GUCY1B2 GUCY1B1 GNGT2 PDE1B PDE1A DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion GNA14 GNA15 PLCB3 PRKCA GNA11 PLCB1 CHRM3 MARCKS PLCB2 GNAQ MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression DPF1 HINT1 DPF2 DPF3 SMARCC1 SMARCC2 SOX10 POU3F2 STT3B DCT TNRC6C MOV10 AGO3 LIG1 AGO4 AGO1 AGO2 PPARGC1A TNRC6A TNRC6B CCND1 SERPINE1 SS18L1 SMARCA2 CEACAM1 SMARCA4 TFAP2A TRPM1 ZEB1 ASAH1 TCF7L2 ATP6V1H CDKN2A SS18 ACTL6A DICER1 GXYLT2 SIRT1 BCL2A1 SYTL2 PMEL EDIL3 MLANA TBX2 MLPH USF1 AKT2 MYRIP CCNB1 ITGA2 LEF1 DIAPH1 PLK1 GMPR BCL2 CDC25B ATP6V1E1 ATP6V1G1 ATP6V0E1 CTNNB1 CDH1 TYR GPR143 ATP6V0D1 ATP6V1A TYRP1 MET IRF4 MYO5A ATP6V1C1 CDH2 CDKN1A TCF7L1 MAPK14 BRCA1 SOX2 BCL7A SIN3A BCL7C BCL7B RAB27A MCM5 MCM2 ATP6V0B ARID1A ARID1B ATP6V1B2 ATP6V0C PXDN BIRC7 PXN SMARCD1 SMARCD2 TCF7 SMARCD3 TERT CDK2 HDAC1 SMARCB1 SMARCE1 ACTB ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 NTF3 PLCG1 NTRK3 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis GALE DOLK DPM1 GFPT1 DPM2 DPM3 SRD5A3 NUS1 GALM PGM1 GALT DHDDS GALK1 GNE PMM2 MPI BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters TCF7L2 AXIN2 RUNX3 TCF7 LEF1 TCF7L1 MYC CTNNB1 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDKN2A CDK4 CDK6 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease ETV6 NOX4 NRAS PIK3R1 BCL2L1 PIM1 PIK3CA ZMYM2 FLT3LG UBA52 GOLGB1 SOS1 FLT3 GAB2 CBL SPTBN1 UBB UBC TRIP11 GRB2 RPS27A PTPN11 STAT5A CDKN1A STAT5B HRAS MYO18A REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation BCL7C BCL7B DPF1 RAB27A SS18 DPF2 DPF3 ACTL6A SMARCC1 SMARCC2 SOX10 ARID1A CTNNB1 ARID1B SYTL2 PMEL MLANA DCT MLPH TYR GPR143 USF1 AKT2 SMARCD1 TYRP1 MYRIP SMARCD2 SS18L1 SMARCD3 SMARCA2 LEF1 SMARCA4 TFAP2A IRF4 MYO5A SMARCB1 MAPK14 SMARCE1 ACTB BCL7A RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT RHOB PPP1R12A MYL6 CDKN1B MYL9 RAC1 PRC1 KIF14 MYH9 RHOA CIT PPP1CB PPP1R12B DLG4 MYH14 MYH11 RHOC MYL12B MYH10 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACADM ACADS MECR ACSM3 HADHB HADHA HADH ACADL ACSM6 ACADVL ECHS1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains HLA-DQB2 CD3G HLA-DRB1 HLA-DQB1 PTPRJ PTPN22 CD4 TRAC PTPRC LCK CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 PAG1 TRAV19 HLA-DRB5 HLA-DRB4 HLA-DPB1 CSK TRAV8-4 HLA-DRA HLA-DRB3 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed SENP5 SENP1 SUMO1 SENP2 SUMO3 SUMO2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 HDAC2 HDAC3 HDAC1 PRDM4 NGFR NGF APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated APC NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway SNW1 MAMLD1 HDAC4 TBL1XR1 NCOR2 KAT2B KAT2A NCOR1 HDAC8 CREBBP HDAC2 HDAC11 TBL1X HDAC3 NOTCH1 HDAC1 MAML2 MAML1 RBPJ HDAC5 HDAC9 HDAC6 HDAC7 MAML3 NOTCH2 NOTCH3 NOTCH4 HDAC10 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome PSMA5 SEM1 GLI3 PSMA6 PSMA3 PSMC5 SUFU PSMA4 PRKACG PSMC6 PRKACB PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL1 PSMD12 CSNK1A1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 GSK3B PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PRKACA PSMD3 PSMB1 PSMD1 SKP1 ADRM1 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants FLT3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation KLB FGF1 FGF4 FGF16 FGF9 FGF19 FGF18 FGF20 FGFR4 FGF23 FGF6 FGF2 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism FFAR1 AGPAT1 GLP1R AKAP5 AHCYL1 KCNC2 PRKAG2 GNAI1 GNAI2 PPP2R1A STX1A ADIPOR1 PLCB3 PRKACA ADIPOR2 GCG PLCB1 PLCB2 KCNS3 CD36 IQGAP1 SLC2A1 SLC2A2 RAPGEF3 RAPGEF4 CHRM3 MLX KCNB1 ABCC8 KCNG2 GNG10 CACNA1A PRKAR2B CACNB2 CACNA1D CACNB3 CACNA1C GNG12 CACNA1E GNG11 GNG13 GNB2 GNAQ ITPR1 GNB1 ITPR2 GCGR SYT5 GNB4 ITPR3 GNB3 GNB5 ACLY GNGT1 GNGT2 VAMP2 ADIPOQ STXBP1 GNA14 GNG3 GNA15 GNG2 GNG5 ACACB GNG4 ACACA ADRA2C GNG7 ADRA2A GNA11 GNG8 SNAP25 PRKCA KCNJ11 MARCKS STK11 PPP2R5D PFKFB1 PPP2CA PPP2CB PPP2R1B PRKACG PRKAA2 PRKACB INS RAP1A ADCY9 PRKAR1B PRKAR1A MLXIPL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A TALDO1 GNAS PRKAB2 TKT FASN CACNA2D2 ACSL4 ACSL3 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation CALM1 AKT1 NOS3 CAV1 CYGB SPR ZDHHC21 CYB5B DDAH1 LYPLA1 NMT1 NMT2 HSP90AA1 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR4N5 OR2J3 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 LDB1 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR1Q1 OR2S2 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 EBF1 OR52M1 OR10V1 OR4C12 OR2AT4 OR4C11 OR6C6 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR10K2 OR4F4 OR2B2 OR4F3 OR10K1 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP2 OR52J3 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR2G6 OR5M9 OR51F1 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 KCNC2 KCNQ2 KCNQ3 KCNK10 KCNK13 KCNJ14 KCNK16 KCNK17 KCNK18 KCNK2 KCNK4 KCNS3 KCND1 KCND2 KCND3 KCNB1 ABCC8 KCNG2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 KCNK9 GNGT1 KCNK3 GNGT2 KCNJ1 KCNJ8 KCNJ2 KCNJ3 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 GNG4 KCNJ10 GNG7 GNG8 KCNJ12 KCNJ9 KCNJ15 KCNJ16 KCNQ4 KCNQ1 KCNJ11 KCNG1 KCNG3 KCNG4 KCNC1 KCNA1 KCNC3 KCNA2 KCNC4 KCNAB2 KCNA3 ABCC9 KCNA4 KCNN2 KCNA6 KCNA7 KCNV1 KCNA5 KCNV2 KCNH1 KCNF1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNB2 KCNH8 KCNN1 KCNN3 KCNAB1 KCNN4 KCNAB3 HCN4 KCNS1 HCN3 KCNS2 KCNQ5 HCN2 KCNA10 HCN1 KCNK6 KCNK7 KCNK1 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC30A5 SLC39A4 SLC30A3 SLC30A2 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE TLR3 TRAF3 TICAM1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening H2AC14 H2BC21 H3-3B H2BC12L H3C8 UBTF H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 MAPK3 H2BC14 H2BC15 H2AJ H2BC11 H4C9 H3C15 H2BC9 H2BC8 H2BC5 H2BC3 MBD2 H2AC20 H2BC1 H2AX H2AC19 PHF6 H2BC26 H2AB1 H2AZ2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR1 TGFBR2 TGFB1 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade IRS1 PIK3R2 PIK3CB NRAS PIK3R1 THEM4 IRS4 FRS2 PIK3CA FGF1 FGF4 FLT3LG FGF16 FGF9 PDPK1 FGF18 FGF20 SOS1 FGF23 TLR9 FLT3 AKT2 GAB2 FGF6 FGF2 PIK3C3 KLB GAB1 IGF2 FGF19 IGF1 FGFR4 TRIB3 PTPN11 IRS2 FGF7 PDE3B IGF1R FGF22 FGF3 FGF10 PIK3R4 HRAS SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer EP300 PSEN2 APH1A HDAC4 APH1B HEYL MYC TBL1XR1 HDAC8 ADAM10 CREBBP PSENEN ADAM17 HDAC11 MAML2 PSEN1 CDK8 MAML1 HDAC5 NCSTN HDAC9 HDAC6 DLL4 MAML3 HDAC7 NEURL1 MIB1 SKP1 HDAC10 HEY1 JAG2 HEY2 SNW1 MAMLD1 NEURL1B RBX1 NCOR2 KAT2B KAT2A UBA52 MIB2 NCOR1 CUL1 HDAC2 TBL1X HDAC3 UBB NOTCH1 HDAC1 UBC RBPJ DLL1 RPS27A HES5 JAG1 HES1 CCNC CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT NFATC1 CALM1 NFATC3 FKBP1A PPP3CA PPP3CB PPP3R1 NFATC2 PPIA BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 PLCG1 FGF1 FGF7 FGF4 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 FGF23 FGF6 FGF2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling ABL2 ROBO1 CLASP2 SLIT2 CAP1 ABL1 CAP2 CLASP1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency BTD DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors S1PR2 S1PR5 S1PR4 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 S1PR1 LPAR5 S1PR3 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency CPS1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation PELI2 IKBKB IKBKG CHUK UBE2N IRAK1 PELI1 TRAF6 PELI3 UBE2V1 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs ATXN3L RAD23B JOSD2 JOSD1 UBB UBA52 VCP UBC PRKN ATXN3 RAD23A RPS27A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis TSNAX TSN AGO3 AGO4 AGO1 AGO2 TARBP2 PRKRA DICER1 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC7A7 SLC3A2 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling NRAS PTPN11 FRS2 FGF1 FRS3 FGF4 FGF22 FGF3 FGF9 FGF10 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly CASP5 DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A ADAMTS6 ADAMTS8 ADAMTS7 SBSPON ADAMTS9 ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS19 ADAMTS17 SSPOP ADAMTS13 ADAMTS16 ADAMTS18 SEMA5A SPON2 SEMA5B THBS1 SPON1 THSD7B ADAMTSL1 ADAMTS4 ADAMTS2 ADAMTS5 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events ST3GAL1 ST3GAL2 ST3GAL3 SRPK2 OST4 EDEM2 PARP16 PARP14 SRPK1 OSTC UBE2I PARP10 STT3A STT3B GSK3A ST6GALNAC2 PRKCSH SUMO1 DDOST MAGT1 DAD1 MAN1B1 ST6GALNAC3 PARP6 ST6GALNAC4 PARP4 PRMT1 ANO8 ANO9 GANAB ANO6 ANO7 ZDHHC11 ANO4 GALNT1 PARP9 ANO5 MGAT4C MGAT4A ANO2 MGAT4B GSK3B PARP8 ANO3 ANO1 CANX ZDHHC20 TMPRSS2 MGAT5 ANO10 MGAT1 MGAT2 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 ZDHHC9 UBA52 TUSC3 GOLGA7 CSNK1A1 UBB FURIN UBC ST6GAL1 TMEM258 MOGS RPS27A ACE2 RPN2 RPN1 FUT8 MAN2A1 ST3GAL4 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation JMJD7 RCCD1 RPS6 JMJD6 U2AF2 F9 ETF1 ZC3H15 RWDD1 RIOX2 RPL27A ASPH RIOX1 DRG1 DRG2 RPS23 KDM8 OGFOD1 JMJD4 RPL8 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR EIF2AK2 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2AC14 H2BC21 MTREX H3-3B H2BC12L H3C8 H2AC8 RBM7 H2AC6 H2AC7 PPHLN1 H2BC17 ZCCHC8 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 TASOR H4C9 SETDB1 H3C15 MORC2 H2BC9 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX EHMT2 H2AC19 MPHOSPH8 EHMT1 H2BC26 ATF7IP H2AB1 H2AZ2 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UPP2 DCK UPP1 TYMP CDA UCKL1 UCK2 UCK1 PUDP TK2 TK1 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers IRS1 PIK3R2 PIK3CB PIK3R1 FRS2 PIK3CA TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B EGF ERBB2 PLCG1 EGFR PPP2R1A PRKX PRKACA MKRN1 WWP2 UBA52 AKT2 AKT3 PSMD12 PSMD11 UBB PRKAR2B PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 ITPR1 PSMB4 ITPR2 PSMD6 PSMB5 PSMD7 ITPR3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 BAD PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ATF2 INSR FOXO6 FOXO4 FOXO3 RRAGA FOXO1 RRAGC RRAGB PDGFRA RRAGD FGF6 AKT1 MAPKAP1 PRKCD PRKCA PRKCE LCK SRC CDKN1A NTRK2 BDNF PDE1C GRK2 RPTOR PRKACG PRKACB THEM4 SGK1 MAPK1 ADCY9 PRKAR1B MAPK3 PRKAR1A RICTOR FGF1 FGF4 STUB1 FGF16 ADCY4 FGF9 FGF18 ADCY3 FGF20 ADCY2 KPNA2 PIK3CD ADCY1 FGF23 PIK3CG ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 TGFA USP7 RAC2 CASP9 SLC38A9 RHOG IRAK1 PDE1B PDE1A VAV1 FYN RHEB PIP5K1A MDM2 GSK3A PIP5K1B PIP5K1C IER3 MYD88 FLT3LG PDGFB CD19 PRR5 EGR1 PDPK1 SNAI1 CD28 IRAK4 SNAI2 STRN GAB2 FLT3 PHLPP2 TRAF6 PHLPP1 MLST8 IL33 CD86 KLB CD80 AHCYL1 TRIM27 ATN1 SALL4 USP13 MAF1 TNKS PDGFRB TNKS2 RNF146 FGF19 FRK FGFR4 AKT1S1 OTUD3 IL1RL1 CAMKK1 TRAT1 CAMKK2 RPS6KB2 PIK3AP1 PTPN11 EPGN EZH2 PIK3R3 MTOR PIK3R6 PML PIK3R5 CALM1 MBD3 SUZ12 NBEA IRS2 GATAD2B GATAD2A PRKCG ESR1 CHUK PPARG HGF TP53 REST BMI1 GAB1 MET PTEN AREG RING1 HDAC5 RNF2 CSNK2A1 HDAC7 FGF7 GSK3B CSNK2A2 FGF22 FGF3 CBX8 FGF10 CHD4 PPP2R5B PHC2 CHD3 PPP2R5A CBX6 PPP2R5D PHC1 PPP2R5C CSNK2B JUN PPP2CA PPP2CB CBX4 CBX2 PPP2R1B PHC3 PPP2R5E TSC2 CDKN1B KDM1A RAC1 NRG1 EED INS NRG2 EREG BTC XIAP NRG3 NRG4 HBEGF CAMK4 KIT NTRK3 FGF2 HDAC2 HDAC3 MECOM PIP4K2A HDAC1 TRIB3 ESR2 PIP4K2B MTA1 NR4A1 PIP4K2C RBBP4 NR2E1 RCOR1 CAMK2B NTF3 CAMK2D NEDD4 PREX2 CAMK2A RBBP7 MTA2 MTA3 CAMK2G INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 SH3PXD2A ADAM12 ADAM19 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death CASP8 RIPK1 RIPK3 FADD TLR3 TICAM1 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm SHH FOXF1 BMP4 IHH GATA4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin MMP3 NRAS PRKCA EGFR HBEGF SOS1 HRAS INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 FBP1 G6PC1 H4C9 H2AC20 H2AX ZMYND8 CHD5 CHD4 IKZF1 CHD3 IKZF2 PHF6 IKZF3 H2BC26 ZNF687 H2BC21 H3-3B TCF19 ZNF592 H3C8 ZNF827 NR2F2 CDK2AP2 CDK2AP1 ZNF532 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 HDAC2 H3C15 MBD3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 MBD2 H2BC1 GATAD2B GATAD2A RBBP7 PCK1 NR2C2 MTA2 MTA3 H2AC19 H2AB1 H2AZ2 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion FASTKD2 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM1 MRM2 MRM3 MTERF3 TFB1M PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase KCNE4 KCNE5 KCNQ1 CACNG7 CACNB2 CACNA1C CACNG6 AKAP9 CACNG8 CACNA2D2 CACNB1 CACNG4 KCNE1 KCNE2 KCNE3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane ATF1 ELK1 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 TLR10 APP MAP3K8 DUSP6 MAP2K3 DUSP7 MEF2A MAP2K4 NFKB2 UBE2N MEF2C TAB3 MAPKAPK3 NFKBIA TAB2 MAPK9 TAB1 ATF2 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 CHUK NKIRAS2 IKBIP IRAK4 PELI1 LRRC14 TRAF6 USP14 PELI3 PELI2 IKBKB NLRC5 TP53 USP18 TIFA MAP3K1 IKBKG S100B RIPK2 SAA1 NOD1 NOD2 MAPKAPK2 PPP2R1A BTRC PPP2R5D RELA MAPK14 SKP1 PPP2CA JUN MAPK11 PPP2CB PPP2R1B MAPK7 FBXW11 NFKB1 FOS TLR5 MAP2K1 TRAF2 MAPK1 CASP8 MAPK3 UBA52 MAP3K7 CUL1 UBB UBC RPS27A ECSIT UBE2V1 MAP2K6 IRAK1 IRAK2 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat ELOA ERCC3 NELFB ELOB NELFCD NELFA ELOC ERCC2 NELFE NCBP1 NCBP2 CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E GTF2H5 POLR2F ELOA2 POLR2H SUPT5H CDK9 CCNH SSRP1 POLR2K POLR2L TCEA1 ELL ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes NOS2 ATP6V1H CYBB CYBA TCIRG1 NOS1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6V1B2 ATP6V0C ATP6V1B1 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0E2 NOS3 SLC11A1 NCF1 ATP6V1G3 NCF2 HVCN1 NCF4 ATP6V0A2 ATP6V0A4 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RAC2 ATP6V0A1 MPO LPO DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis CASP8 RIPK1 RIPK3 MLKL SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants CALM1 VCL NRAS PHB1 JAK2 ARRB2 MAP2K1 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 ITGB3 MAP3K11 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG BRAP RAP1B KRAS VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 CAMK2B CAMK2D PEBP1 CAMK2A CSK HRAS CAMK2G TLN1 FN1 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome KMT2D WDR5 DPY30 ASH2L RBBP5 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes TP53 ZNF385A PCBP4 CDKN1A GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation PRKACG PRKACB ADCY9 PRKAR1B GNG3 PRKAR1A GNG2 GNG5 ADCY4 GNG4 GNG7 ADCY3 ADCY2 GNG8 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNG10 PRKAR2B GNG12 GNAS GNG11 GNG13 GNB2 GNB1 GCGR GNB4 GNB3 PRKACA GCG SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants DUSP16 DUSP10 DUSP8 DUSP9 DUSP6 DUSP7 MAPK1 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT DAAM1 MYC PORCN TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B LRP5 LRP6 RUNX3 PPP2R1A BTRC PLCB3 PLCB1 PLCB2 SKP1 TCF7L2 CSNK1E UBA52 DKK1 DKK2 DKK4 AKT2 CUL1 CHD8 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC LEF1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 ITPR1 PSMB4 ITPR2 PSMD6 PSMB5 PSMD7 ITPR3 PSMB2 SOX17 PSMB3 RNF43 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 DVL1 PSMA3 DVL2 PSMC5 PSMA4 DVL3 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 KAT5 ZRANB1 KREMEN1 KREMEN2 XPO1 AKT1 PRKCA YWHAZ PARD6A RBX1 PFN1 VPS29 SOX3 VPS35 SOX6 SOX7 SOX4 MAP3K7 WLS SOX13 HECW1 VPS26A CCDC88C RSPO2 RSPO1 RSPO4 CSNK1A1 TMED5 LGR6 LGR5 LGR4 CTNNBIP1 KLHL12 CBY1 DACT1 CXXC4 ZNRF3 RAC2 RAC3 H2AC19 H2AC14 CUL3 H2BC12L CAV1 PIP5K1B WNT10B WNT10A TLE5 CREBBP H4C9 CSNK1G2 TNKS TNKS2 RNF146 SMARCA4 WNT8A WNT8B H2AC20 WNT7B SNX3 H2AX WNT7A USP34 ASH2L TRRAP RSPO3 CALM1 H3-3B PRKG2 H3C8 H2AJ H3C15 GNG10 H2BC9 H2BC8 GNG12 H2BC5 GNG11 GNG13 H2BC3 H2BC1 GNB2 GNB1 WNT6 GNB4 GNB3 RUVBL1 WNT2 WNT3 GNB5 GNAT2 PRKCG GNGT1 WNT5B WNT5A ROR1 GNGT2 H2AB1 ROR2 NLK WNT2B PPP3R1 EP300 WNT1 FZD1 FZD3 FZD2 FZD5 MEN1 FZD4 FZD7 H2AC8 FZD6 FZD8 H2AC6 H2AC7 GNAO1 CLTB ARRB2 PPP3CA CTBP2 PPP3CB CTBP1 PRKG1 PRICKLE1 PDE6B PDE6A WNT16 GNG3 PDE6G RYK KMT2B GNG2 GNG5 GNG4 GNG7 GNG8 CLTC SRY CLTA AP2A1 AP2B1 AP2A2 CSNK2A1 AP2S1 GSK3B CSNK2A2 AMER1 DPY30 AXIN1 PPP2R5B PPP2R5A TCF7L1 WNT3A PPP2R5D PPP2R5C CSNK2B PPP2CA H2BC26 PPP2CB SOX2 FRAT1 USP8 FRAT2 NFATC1 WNT9A APC PPP2R1B SFRP1 H2BC21 SFRP2 PPP2R5E WIF1 SOST WDR5 SOX9 RAC1 SCRIB RHOA H2BC17 XIAP H2BC12 H2BC13 VANGL2 H2BC14 H2BC15 H2BC11 CDC73 TLE4 TLE3 TLE2 TLE1 AXIN2 PYGO1 WNT11 PYGO2 TCF7 TERT LEO1 SMURF2 HDAC1 BCL9L SMURF1 BCL9 WNT4 H3-4 RBBP5 WNT9B CAMK2A PRKCB H2AZ2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol ITPK1 IPPK NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K1 NUDT3 IP6K3 NUDT4 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling IL33 IL1RL1 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) SLC6A19 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC MAGED1 DAPK3 APPL1 UNC5A UNC5B CASP3 DCC CASP9 DAPK1 DAPK2 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events GNAT3 PDE2A GNAZ RXFP1 PDE11A RXFP2 MC4R PDE10A GLP1R GPR176 ADORA2B GNAI3 GHRHR ADM MC3R MC1R GPR15 MC5R CALCRL GPR27 GPR25 GPR20 PTH1R GPR32 PTH2R GPR45 GPR150 GNAI1 GNAI2 ARRB1 SCTR ADM2 LHCGR PRKACA GPR83 TSHR GPR84 FSHR RLN2 GPHA2 GCG RLN3 GPHB5 CALCA INSL3 PTH2 VIPR1 VIPR2 PTGDR GIPR CRHR1 PDE3A GPBAR1 PTGER4 TSHB RAMP3 PTH FSHB PTGER2 GNG10 GHRH CRHR2 MC2R PRKAR2B RAMP1 PDE8B GNG12 PDE8A GNG11 GNG13 GNB2 CALCB GNB1 GCGR GRK3 CALCR GNB4 GRK6 GNB3 GNB5 ADCYAP1 ADCYAP1R1 GNGT1 GNGT2 DRD1 POMC DRD5 GPR39 GPER1 PDE4A ARRB2 PTGIR PDE4D NPSR1 GLP2R PDE4C LHB NPS GNG3 GNG2 GNG5 GNG4 P2RY11 ADORA2A GNG7 PTHLH GNG8 AVP PDE7B VIP AVPR2 PDE7A IAPP SRC CRH PDE3B GRK5 GRK2 ITGA5 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A CGA ITGB1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADRB1 GIP ADCY5 ADRB2 HTR4 HTR6 PRKAR2A TAAR3P HTR7 HRH2 TAAR8 GNAS TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADRB3 RAMP2 SCT CYSLTR2 PDE1B PDE1A SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis PRKD2 CERS1 PRKD1 SPHK1 CERS2 KDSR CYB5B SAMD8 SPTLC1 SPTLC2 FA2H SPTLC3 ABCC1 CSNK1G2 MFSD2B VAPA VAPB SPNS2 ORMDL2 CERS3 OSBP ORMDL3 CERS4 ABCG2 CERS5 CERS6 SGMS1 SPTSSB ORMDL1 PPM1L SGMS2 DEGS1 SPTSSA DEGS2 SPHK2 PRKD3 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 TREX1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades NFKB1 TLR10 UNC93B1 TLR6 LY96 NFKB2 TLR5 NFKBIA TICAM1 S100A1 CD14 BTK MYD88 HMGB1 TLR4 CHUK IRAK4 FGB FGA TRAF3 FGG IKBKB IKBKG TIRAP TLR1 S100A9 S100A8 TLR2 RELA TLR7 TLR3 CD36 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2A1 CLOCK BMAL1 CDK5 CSNK2B ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AB1 HSP90AA1 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD4 SMAD3 FOXO3 BCL2L11 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction STAT3 PIK3R2 PIK3CB NRAS PIK3R1 STAT1 RAPGEF1 CRKL PIK3CA PDGFB CRK GRB7 SOS1 PDGFRA NCK2 NCK1 PLCG1 PDGFRB BCAR1 PTPN11 SRC STAT6 STAT5A STAT5B HRAS RASA1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling TCF7L2 RUNX3 TCF7 LEF1 TCF7L1 MYC CTNNB1 CCND1 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis SLC37A1 PGK1 PGK2 SLC37A4 PC FBP1 ALDOC FBP2 ALDOB G6PC1 ALDOA G6PC2 G6PC3 ENO1 ENO2 ENO3 ENO4 GPI GAPDHS TPI1 PCK1 PGAM1 PCK2 PGAM2 GAPDH DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 AMN CUBN CBLIF TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins ST3GAL1 ST3GAL2 ST3GAL3 PARP16 MGAT1 PARP14 UBE2I PARP10 GSK3A ST6GALNAC2 PRKCSH SUMO1 UBA52 ST6GALNAC3 PARP6 ST6GALNAC4 UBB PARP4 UBC GANAB ST6GAL1 MOGS RPS27A GALNT1 PARP9 GSK3B PARP8 CANX ST3GAL4 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle WDR6 FAM83B PIK3R2 ANKRD26 DST PIK3R1 CAV1 ARHGAP35 KIDINS220 TXNL1 SCRIB ALDH3A2 GOLGA3 LEMD3 CKAP4 KTN1 NISCH VANGL1 FRS2 DEPDC1B VANGL2 UBXN11 FRS3 DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 ARHGAP1 PLXND1 LRRC1 NUDC PTPN13 KIF14 TFRC BLTP3B PRAG1 RND2 TNFAIP1 ARHGAP5 FNBP1 MUC13 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol ISYNA1 INPP5J INPP1 INPP4A MTMR9 INPP4B IMPA1 IMPA2 OCRL MIOX MTMR7 SYNJ1 INPP5B INPP5A REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation TAF4 TAF3 TAF2 TAF1 TP53RK NOC2L MDM2 PIN1 KAT5 MDM4 CHEK2 CHEK1 RAD9B SUPT16H RAD9A HUS1 PRKAB1 DYRK2 EXO1 DNA2 RHNO1 TOPBP1 TP53 RFC5 RFC3 NUAK1 RFC4 RFC2 ATRIP PRKAG2 CDK5 BARD1 PLK3 PRKAA1 AURKB TPX2 TP53INP1 RAD17 STK11 CSNK2A1 RBBP8 ATM ATR CSNK2A2 PRKAG1 RAD50 CDK5R1 MAPK14 TAF4B BRCA1 CSNK2B MAPK11 PRKAG3 TAF7L RMI2 PRKAA2 RMI1 TOP3A TBP WRN UBA52 RPA1 RPA2 HIPK1 HIPK2 TAF9 RPA3 AURKA RAD1 TAF1L UBB CDK2 CCNA2 MRE11 CCNA1 UBC NBN RPS27A TAF9B BRIP1 TAF15 PRKAB2 TAF12 MAPKAPK5 TAF13 BLM TAF10 TAF11 SSRP1 TAF8 TAF7 TAF6 TAF5 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols FDX2 POMC NCOA1 NCOA2 CYP21A2 NR1H4 CYP27A1 RXRA CYP11A1 CYP4V2 AHR ARNT2 CYP7B1 ARNT FDXR CYP51A1 CYP11B2 CYP39A1 CYP11B1 CYP1B1 CYP7A1 AHRR CYP8B1 CYP46A1 CYP19A1 FDX1 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 TOP2A CDC6 E2F5 CDC25A MYC PCNA LIN54 DYRK1A LIN37 LIN9 LIN52 MAX MYBL2 CCNE2 CCNE1 CDK2 HDAC1 CCNA2 CCNA1 RBL2 RBL1 RBBP4 TFDP1 TFDP2 E2F4 E2F1 CDK1 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHOB RTKN TAX1BP3 ROPN1 RHPN1 LIN7B RHPN2 RHOC RHOA REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 CTBP2 CTBP1 ZMYM2 TCF3 SP1 SNAI1 SNAI2 TGIF2 H4C9 STRAP SMARCA4 TFAP2A H2AC20 FOXQ1 DNTTIP1 ZBTB33 EZH2 H2AX FOXP2 FOXA2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 H2BC26 KLF4 H2BC21 H3-3B H3C8 KDM1A TCF12 EED TWIST2 TWIST1 ARID1A H2BC17 SIRT1 MAPK1 H2BC12 H2BC13 H2BC14 MAPK3 H2BC15 H2AJ H2BC11 ZNF217 TLE1 HDAC2 H3C15 HDAC1 SUZ12 H2BC9 H2BC8 H2BC5 KMT5A H2BC3 RBBP4 H2BC1 RB1 RBBP7 H2AC19 MPHOSPH8 WT1 H2AB1 H2AZ2 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP62 RAN NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 XPO1 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors HRH3 HRH2 HRH4 HRH1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization RNF19B JAK2 HEYL MYC SOX10 MYCN TNRC6C JUP MOV10 CDH5 AGO3 AGO4 AGO1 AGO2 CDC42 CDH11 TNRC6A TNRC6B CLDN5 STRAP TFAP2A PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 POMT2 RELA POMT1 FARP2 VCL NFKB1 IL6 TRAF7 PATJ UBA52 ZNF217 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 MOGS PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 RPN1 PSMB1 PSMD1 ADRM1 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 ZMYM2 JAK1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 TYK2 SRC PCSK6 PARD6B PARD6A TIAM1 CANX CTSS CTSL CTSB MAPK1 MAPK3 CRB3 FURIN PCSK7 CSNK2A3 ANK3 TMEM258 KMT5A RB1 F11R PARD3 H2AC19 H2AC14 VAV2 H2BC12L OST4 ARHGEF4 OSTC STT3A PVR PALS1 MDM2 PIP5K1C PRKCSH TCF3 SNAI1 DDOST SNAI2 CTNNA1 TGIF2 DAD1 H4C9 SMARCA4 GANAB H2AC20 NECTIN2 FOXQ1 DNTTIP1 EZH2 ZBTB33 H2AX FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 H3-3B H3C8 TCF12 SIRT1 CLDN2 ZC3H12A CLDN6 CLDN4 H2AJ CLDN3 CLDN9 ANG CLDN8 CLDN7 CADM3 CADM1 CADM2 ANGPTL4 CLDN22 CLDN20 CLDN23 H3C15 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 SUZ12 CLDN19 H2BC9 CLDN18 H2BC8 CLDN17 H2BC5 CLDN16 ARHGAP32 H2BC3 ADAM33 H2BC1 CDH9 IL6ST CDH8 CDH7 CDH6 CDH3 IL6R ADAM19 MPHOSPH8 CDH24 SDK1 SDK2 H2AB1 CDH10 CDH12 CDH13 CDH17 CDH18 CDH19 PARD6G NECTIN4 H2AC8 NECTIN3 NECTIN1 H2AC6 H2AC7 CTBP2 CTBP1 SP1 PRKCI CDH4 SEC11A CDH2 SEC11C DNM2 CSNK2A1 FOXA2 CSNK2A2 CDH15 CSNK2B H2BC26 KLF4 H2BC21 KDM1A RAC1 TWIST2 EED TWIST1 ARID1A SPCS3 H2BC17 SPCS2 XIAP SPCS1 H2BC12 H2BC13 H2BC14 H2BC15 ELMO1 DOCK1 HACE1 H2BC11 BIRC2 TLE1 HDAC2 HDAC1 RBBP4 CLDN1 RBBP7 WT1 H2AZ2 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism PM20D1 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP3 IGF2BP2 IGF2BP1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer SMAD2 SMAD4 SMAD3 TGFBR1 TGFBR2 TGFB1 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria ASL NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription EP300 MAMLD1 MAML3 NOTCH2 FCER2 GZMB MAML2 MAML1 RBPJ HES1 HES5 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 BRCA2 RAD51AP1 BRIP1 RBBP8 ATM BLM XRCC2 PALB2 RAD50 BRCA1 RAD51 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation VCL NRAS ARRB2 MAP2K1 WDR83 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF IL17RD MAPK3 ITGB3 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG RAP1B LAMTOR2 LAMTOR3 VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 PEBP1 CSK HRAS TLN1 FN1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis FUOM GMDS FCSK SLC35C1 FPGT GFUS SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 KLB NRAS FGF19 FGFR4 FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses GJC1 GJA10 PANX2 GJD2 PANX1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases MMP25 MMP24 CTSK TIMP2 PRSS1 CTSG TIMP1 TPSAB1 MMP7 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 PRSS2 MMP11 MMP14 CTRB2 MMP13 CTRB1 MMP16 MMP15 MMP17 PLG FURIN SPOCK3 KLK2 CMA1 ELANE KLKB1 COL18A1 CTSV AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOB PAOX MAOA CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC7 UBE2C UBE2E1 CDC20 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC14A ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing RAB27A VAMP2 KIF5C INS KIF5B KIF5A PCSK2 EXOC8 EXOC7 ERO1B PCSK1 SLC30A8 SLC30A5 EXOC4 EXOC3 MYRIP EXOC6 P4HB EXOC5 EXOC2 EXOC1 CLTRN MYO5A CPE STX1A DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A5 SLC30A3 SLC30A2 SLC30A1 SLC30A8 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 AGO3 PTEN AGO4 AGO1 AGO2 TNRC6A TNRC6B TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC28A2 SLC25A5 SLC29A1 SLC28A1 ARL2 SLC29A3 SLC29A2 SLC28A3 SLC25A6 ARL2BP SLC29A4 SLC25A4 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin STAT3 IRS2 LEP IRS1 STAT5A JAK2 STAT5B SOCS3 PTPN11 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 GAB1 CDC37 UBB EGF NRAS PIK3R1 PLCG1 EGFR UBC RPS27A PIK3CA UBA52 SOS1 HRAS CBL HSP90AA1 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation HBA2 HBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity ROBO1 MYO9B SLIT2 RHOA DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine SQOR ADO CSAD SUOX TXN2 MPST CTH SLC25A10 GOT2 GADL1 FMO1 CDO1 TST TSTD1 ETHE1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response NUP37 NUP107 NUP188 HIKESHI CCAR2 DNAJC2 DNAJC7 RPS19BP1 NUP210 HSPA4L HSPA14 HSPA5 HSPA13 DNAJB1 NUP93 HSPH1 BAG5 DNAJB6 BAG3 BAG1 NUP205 HSPA1L POM121 HSPA4 NUP214 ST13 HSPA7 HSPA6 AAAS HSPA12A HSPA12B YWHAE MAPKAPK2 NUP160 POM121C NUP85 TPR NUP88 NUP155 ATM GSK3B NUP153 ATR HSPA8 HSPA9 HSPA1A NUP62 HSPA2 NDC1 SEC13 NUP133 SIRT1 MAPK1 MAPK3 NUP50 NUP54 RPA1 RPA2 RPA3 NUP42 NUP43 RAE1 RANBP2 HSPA1B HSF1 BAG4 BAG2 NUP35 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways EP300 SMAD4 SMAD3 CAV1 PSMC6 YWHAZ YWHAE UBE2I YWHAQ YWHAH PDPK1 SP1 YWHAG YWHAB SFN SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane PIK3C3 PIKFYVE MTMR2 MTMR7 FIG4 VAC14 MTM1 PIK3R4 MTMR9 PIK3C2A MTMR4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK MAPK7 RPS6KA3 NRAS RPS6KA2 GAST PRKCA RPS6KA1 EGFR CCKBR MAPK1 MMP3 MAPK3 HBEGF SOS1 HRAS CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism SLC37A1 GNPDA1 GNPDA2 NUP37 HK2 HK1 PGK1 HK3 PGK2 NUP107 NUP188 SLC37A4 FBP1 PC ALDOC FBP2 ALDOB ALDOA G6PC1 G6PC2 G6PC3 NUP210 NUP93 NUP205 POM121 NUP214 AAAS NUP160 POM121C NUP85 TPR PFKL NUP88 NUP155 PFKM PPP2R1A PFKP NUP153 PRKACA ADPGK PPP2R5D GAPDH PFKFB2 GCKR PFKFB1 PPP2CA GCK PFKFB4 PPP2CB PGM2L1 PFKFB3 NUP62 PPP2R1B PRKACG PRKACB NDC1 SEC13 NUP133 BPGM NUP50 NUP54 ENO1 ENO2 ENO3 ENO4 GPI GAPDHS NUP42 HKDC1 NUP43 TPI1 RAE1 RANBP2 PCK1 PGAM1 PGAM2 PCK2 NUP35 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy VPS33A VPS16 VPS41 UVRAG VPS45 VPS33B VPS39 VPS18 TUFM MAP1LC3B VPS11 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization HMG20B KANSL1 KANSL2 KANSL3 JAK2 TCF4 MYOG CCND1 MYOD1 CTR9 RTF1 PAF1 PWWP2B DHX15 ZMYND8 CHD5 IKZF1 MBD3L2 IKZF2 RELA PHF6 IKZF3 MBD3L1 ADNP2 PWWP2A ZNF687 TCF19 ADNP ZNF592 ZNF827 CBX1 NR2F2 NFKB1 CDK2AP2 DDX46 CDK2AP1 ZNF532 DDX42 RBM17 SMNDC1 U2SURP SNRPD2 DKK2 SNRPD1 SNRPD3 SNRPA1 CHD8 CHD7 CHD6 CTCF NKD2 FAM124B IGF2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 CHERP PUF60 SNRPB2 ATF2 CTNNB1 BCL11A FBP1 KAT5 MEAF6 PRMT1 CARM1 ING5 PRMT5 BRD1 RPS2 PHF10 BCL11B BRD7 SNRPG KMT5A SNRPE SNRPF KAT6A SMARCB1 SNRPB SMYD2 EHMT2 H2AC19 EHMT1 ACTB BRPF1 BRPF3 H2AC14 H2BC12L SAP130 DPF1 DPF2 KAT8 CLOCK DPF3 SMARCC1 SMARCC2 HCFC1 SUPT16H TCF3 KAT14 CREBBP NQO1 H4C9 SETDB1 SETD1B SS18L1 SETD1A SMARCA2 SMARCA4 TADA2A ZZZ3 H2AC20 EZH2 H2AX PHF20 SUV39H1 ASH2L SGF29 HDAC10 TRRAP H2AC17 H2AC12 EPC1 H3-3B KAT7 NCOA1 SUPT20H NCOA2 ATXN7L3 H3C8 JMJD6 SS18 WDR77 TCF12 PADI3 PADI2 PADI4 ACTL6A PADI1 PADI6 PRDM16 SETDB2 TADA2B H2AC25 H2AC21 PHF2 NCOR2 SUV39H2 SETD2 KAT2B SETD3 KAT2A SETD6 H2AJ SETD7 PHF8 ING4 NCOR1 ING3 AEBP2 PRMT6 PBRM1 PRMT7 ACTL6B PRMT3 ASH1L TAF9 SUPT3H TAF6L GPS2 DOT1L H3C15 NSD3 TBL1X NSD1 SF3B1 NSD2 BRD8 MBD3 SUZ12 ELP1 H2BC9 ELP2 H2BC8 ELP3 H2BC5 ELP4 MCRS1 ELP5 H2BC3 ELP6 MBD2 PRDM9 H2BC1 KDM1B JADE1 ARID4A YEATS4 JADE3 JADE2 GATAD2B RUVBL2 TAF12 GATAD2A RUVBL1 KMT5B TAF10 ARID2 KDM2A SSRP1 KDM2B KMT5C ARID5B H2AC1 H2AB1 SUPT7L ARID4B MORF4L1 BRMS1 EP300 KAT6B MORF4L2 HAT1 ENY2 TAF5L ATXN7 H2AC8 EP400 SMYD3 H2AC6 DMAP1 H2AC7 UBE2I COPRS NFKB2 MRGBP SAP30 RIOX2 TADA1 BRWD1 TBL1XR1 KDM5A KDM5B KDM5C KMT2D KDM5D VPS72 KMT2A UTY KMT2C G6PC1 KDM6B KMT2B MSL2 SUMO1 MSL3 H2BC18 MSL1 CHD2 KDM7A KDM3A PHF5A MBIP KDM3B HDAC8 KDM4A KDM4B KDM4C KDM4D SNRPN SUDS3 USP22 REST DR1 CBX3 MAFK NFE2L2 CHD9 YEATS2 SKIC8 TADA3 OGT DPY30 CHD4 CHD3 PAX3 H2BC26 BCL7A H2BC21 BCL7C BCL7B KDM1A BICRAL WDR5 BICRA BRD9 KDM6A EED DNMT3A ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PHF21A CDC73 SMARCD1 AXIN2 HDAC2 SMARCD2 HDAC3 MECOM CDK4 SMARCD3 LEO1 HDAC1 MTA1 RBBP4 RBBP5 SAP30L RCOR1 SAP18 PCK1 RBBP7 NR2C2 MTA2 MTA3 ATF7IP SMARCE1 H2AZ2 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling LCAT APOE APOC3 ALB CETP APOC2 APOA1 ABCG1 LIPG AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 KICS2 SEH1L ATP6V1E1 WDR59 ATP6V1E2 RHEB ATP6V1G1 ATP6V0E1 ATP6V1G2 MIOS WDR24 RRAGA RRAGC RRAGB ATP6V0D1 RRAGD ATP6V0D2 MLST8 ATP6V1A FNIP1 FNIP2 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ITFG2 KPTN SZT2 MTOR RPTOR FLCN ATP6V1H SAMTOR NPRL2 TCIRG1 NPRL3 SEC13 ATP6V0B ATP6V1B2 ATP6V0C ATP6V1B1 CASTOR1 CASTOR2 SESN1 SH3BP4 LAMTOR2 LAMTOR1 ATP6V0E2 LAMTOR4 ATP6V1G3 LAMTOR3 LAMTOR5 SESN2 DEPDC5 SLC38A9 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 TBP SSB NFIX NFIA NFIB NFIC BRF2 BDP1 POLR1C POLR1D CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H GTF3C1 POLR3K GTF3C2 POLR2H GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR2K ZNF143 POLR2L BRF1 POU2F1 GTF3A RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling RAP1B PRKACG YWHAZ PRKACB RAP1A SIPA1 RAP1GAP2 RAP1GAP RAPGEF3 RAPGEF4 PRKACA RASGRP2 RASGRP1 YWHAB RAF1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 MEF2C PIM1 KPNA7 MAPKAPK3 KPNA4 MAPK9 KPNA5 MAPK8 KPNA3 MAP2K7 MAPK10 TNIP2 PPM1B CCR2 PRTN3 COL1A2 CD4 LCN2 PSMD12 PSMD11 PSMD14 PSMD13 ARF1 PSMA7 RPLP0 PSMB6 PSMD8 UBE2D3 RORC PSMB7 PSMB4 PSMD6 PSMB5 HSPA1B PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 EIF4G3 PSMA5 EIF4G2 EIF4E3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 VAMP2 PSMC3 ITGAX PSMA1 PSMA2 PTPN12 PSMC4 PSMC1 PSMC2 PTGS2 FOXO3 FOXO1 AKT1 NUP214 ADAR PRKCD YWHAZ MAPKAPK2 S1PR1 HSPA8 STX4 KPNB1 TNFSF13 TNFRSF18 MAPK14 MAPK11 HSPA1A EIF4G1 RBX1 IL2RA PTPN4 PIK3CD YES1 HRAS VEGFA NRAS NUP107 NUP188 IL2 IL3 KPNA1 NUP210 NUP93 NUP205 POM121 HSP90B1 JUNB AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 STX1A NUP153 PIK3R3 IL9 IL9R NUP62 ELOB ELOC CCR5 NDC1 SEC13 NUP133 NUP50 NUP54 NUP42 NUP43 CSF2 RAE1 RANBP2 NUP35 NUP37 CHUK UBA7 HSPA5 IFI6 EIF2AK3 UBE2L6 ISG15 IFI44L IFIH1 HERC5 IKBKB IFI27 TRIM25 ARIH1 IKBKG ATF6 RIGI FKBP5 PPP2R5A PPP2R5D PPP2CA PPP2CB PPP2R1B SAMHD1 TWIST1 ITGB1 GATA3 FGF2 LIFR SMAD3 SMAD7 YBX1 OPRM1 CAMK2B CAMK2D CAMK2A CAMK2G IRS1 PIK3R2 PIK3CB TNFSF11 PIK3R1 IL2RG HIF1A PTPRZ1 MYC JAK3 PLCG2 PIK3CA PTPN6 F13A1 TGFB1 CCND1 KRAS ALOX5 EIF2AK2 CSF1R UBE2D1 RELA UBE2E1 NFKB1 IL6 HSPA2 RPS15 RPS14 RPS17 RPS16 TBK1 RPS19 MUC1 RPS18 AKT2 AKT3 RPS11 B2M RPS10 RPS13 AIP RPS12 HLA-H HLA-B DNAJC3 HLA-C HLA-A HLA-F HLA-G HLA-E RPS4Y2 RPS4Y1 IFIT1 IFIT3 IFIT2 SFN PTPN7 IL34 GAB3 PTPRJ ANXA1 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPS20 PTAFR RPS21 RPS24 RPS23 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 RAF1 JAK1 RIPK2 PTPN13 TYK2 IL17RC IL17RA CANX RPS27L RPS15A RPS3 RPS2 STAT1 IFNB1 STAT2 IL17F FAU IL17A MAOA KPNA2 MAP3K7 RPS9 IFNA14 RPS7 RPS8 IFNA16 RPS5 INPP5D IFNA17 RPS6 RPSA UBE2V1 IFNA10 IFNAR1 TARBP2 IGHG4 PRKRA IRAK1 IRAK2 IGHG1 IFNA21 SYK HCK MAVS FPR1 FYN FCGR1A UBE2N TAB3 TAB2 TAB1 ALPK1 NLRX1 AGER S100A12 N4BP1 MYD88 RPS4X NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP RPS3A IRAK4 IRF3 PELI1 LRRC14 TRAF3 TRAF6 USP14 PELI3 IRF7 PELI2 NLRC5 USP18 TIFA BECN1 S100B SAA1 NOD1 NOD2 PTPN11 ZEB1 HSPA9 GRAP2 OPRD1 CSF2RB CSF2RA CISH CSH1 IRS2 EBI3 IL27 PRL IL6ST PRLR CRLF1 GHR IL27RA GH2 SOCS2 GH1 SOCS1 POMC SPHK1 TCP1 APP NFKB2 SP100 CASP1 SIGIRR IRAK3 RAP1B HGF TNFRSF14 SLA2 TSLP IL31RA IL18BP JUN STX3 PTPN18 CRLF2 SOX2 SLA MAPK7 CIITA TRIM68 CDKN1B TRIM62 TRIM21 TRIM46 TRIM48 TRIM45 IL2RB TRIM35 TRIM38 TRIM31 TRIM34 IL36A IL36B TRIM29 CRK TRIM26 LGALS9 TRIM22 TRIM17 DUS2 CBL SOCS3 TRIM14 TRIM10 PTPN1 IL36G IL1F10 IL20 IL25 IL26 IL24 FAAP24 FAAP20 IL11 FAAP100 IL15 CENPX IL19 IL16 FANCM FANCL FANCA FANCB FANCE PGGT1B FANCG MAP3K3 NEDD4 FANCF IL31 IL37 OSM IL18R1 RAG2 RAG1 IL36RN CXCL8 EIF4A3 IL7R CXCL1 JAK2 CXCL2 IL1RL2 TEC THOC5 CNTF TOLLIP IRF1 CCL11 CCL3L3 IRF2 IL10RB CLCF1 CSF3 CDC42 CCL5 IL5RA CCL4 CUL5 SH2B3 CCL2 IL13RA2 IL13RA1 CCL19 ILF2 CCR1 CAPZA1 CCL22 CCL20 IFITM3 IL1RN CXCL10 IFITM2 IFIT5 IL15RA IL1R2 STXBP2 ILF3 LIF IL11RA UBA3 EIF2S3 OASL OAS1 OAS3 EIF2S2 EIF2S1 IFNL2 UBE2M IFNL1 NOS2 IFNL3 GBP3 GBP5 GBP7 RALA PITPNA BOLA2B LMNB1 IL20RA CNN2 IL20RB HNRNPDL IL22RA2 FASLG CFL1 STAT4 IL12B TRAF2 IL22RA1 IL12A IL12RB1 CASP8 PAK2 IL12RB2 IL10 RNASEL SERPINB2 CTF1 ANXA2 FLNB MSN UBE2D2 MIF RNF7 SOD2 SOD1 VAMP7 TXLNA FSCN1 IFNG HNRNPF HNRNPA2B1 IL1RAPL1 PDCD4 PSME2 PTPN9 SNRPA1 LCP1 PTPN5 PTPN2 IFI35 RSAD2 OSMR HLA-DQA2 HLA-DQA1 HLA-DPA1 IL17C HLA-DRB5 HLA-DRB4 MID1 HLA-DPB1 ISG20 IL7 HLA-DRA HLA-DRB3 IRF6 IRF9 HLA-DQB2 MX2 HLA-DRB1 MX1 LYN HLA-DQB1 DUSP4 DUSP3 CNTFR VRK3 FCGR1BP DUSP6 DUSP7 NFKBIA ATF2 PSMB8 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 HAVCR2 CSF3R IGHE NDN XAF1 PTPN20 PTPN23 IL3RA EIF4E2 PTPN14 PDE12 CDKN1A IFNLR1 IL17RE IL17RB IL18RAP ABCE1 FOS MAP2K1 RAPGEF1 MAPK1 CRKL MAPK3 IFI30 ICAM1 NPM1 SOS1 IL21 TNFRSF13C P4HB RELB CD40LG VCAM1 ITGB2 GSDMD TNFSF13B IRF8 MAP2K6 FANCC BCL6 PIN1 SQSTM1 FLT3 HSPA1L BIRC5 IL18 IL1A IL1B PML GSTO1 EIF4A2 EIF4A1 MAP3K14 TNFRSF6B EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF12A TNFRSF1B EDAR EIF4E LTA TNFRSF25 LTB TNFRSF11B TNFRSF11A TNFRSF17 TNFSF18 TNFSF14 TNFSF15 CD70 TNFSF12 TNFRSF9 TNFSF6 TNFSF4 TNFSF9 CD27 TNFSF8 LTBR UBE2I RORA BRWD1 IL23R IP6K2 IL23A PIAS1 SUMO1 PPIA TP53 SNAP25 MT2A TALDO1 LBP PLCG1 PPP2R1A BTRC PRKACA SKP1 HSP90AA1 FLNA FBXW11 INPPL1 UBA52 CUL1 SHC1 CENPS UBB UBC RPS27A CDK1 BCL2L11 STAT3 BCL2 FCER2 CA1 ABL2 BCL2L1 IL21R GRB10 IFNGR1 IFNGR2 NCK1 ADAM17 EIF1AX LCK EIF3M EIF3K SOS2 EIF3L SRC EIF3I EIF3J SOCS6 EIF3G EIF3H SOCS5 EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B CSK MTAP CASP3 CTSG TIMP1 MMP1 MMP2 HMOX1 MMP3 MMP9 IFITM1 CD44 LAMA5 FURIN ACTB VAV1 RHOU NANOG FLT3LG EGR1 GAB2 IL33 CD86 IL32 CD80 SMARCA4 IL1RL1 ACTG1 FN1 CD36 SNCA H3C8 FNTA FNTB H3C15 DHX9 BST2 GRB2 IL22 IL6R ITGAM IRF5 PTK2B IL10RA VIM TNF MCL1 IL4R IL13 IRF4 CEBPD CCL3 STAT6 STAT5A STAT5B IL1R1 POU2F1 BATF IL4 IL5 GSTA2 TNFRSF1A BIRC2 BIRC3 NCAM1 ALOX15 BLNK OAS2 GBP2 GBP1 GBP4 GBP6 CSF1 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation GSTT2 GSTT1 GGT1 GSS OPLAH GSTA5 GSTA4 GSTA3 GSTA2 GSTA1 GGCT GSTZ1 CNDP2 GSTM4 MGST3 GSTP1 GSTM3 MGST1 GSTM2 MGST2 GSTM1 GGT5 GGT7 GGT6 GSTM5 GCLC AKR1A1 GCLM GSTT2B GGT3P HPGDS GSTK1 GSTO2 GSTO1 ESD CHAC2 CHAC1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation PIK3CA PIK3R2 PIK3CB PIK3R1 ICOSLG PIK3R3 PIK3R6 PIK3CD PIK3R5 PIK3CG DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors CHRM1 CHRM5 CHRM3 CHRM2 CHRM4 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development RPS6KA3 RPS6KA5 EIF4A3 RPS6KA2 CASC3 RPS6KA1 MAGOH ALCAM SCN11A SCN10A AGAP2 L1CAM LYPLA2 DSCAML1 SHC3 RAP1GAP DAB1 PTPRA CNTNAP1 SPTB ITGA9 NTN4 ABLIM1 CDC42 ABLIM2 ABLIM3 NFASC EPHB6 RPS6KA4 CUL2 EPHB2 EPHB1 RBM8A EPHB4 SCN1B SCN1A EPHB3 EPHA5 EPHA7 EPHA6 EPHA8 ANK2 SHTN1 UPF3B KCNQ2 MAGOHB KCNQ3 EPHA1 MBP EPHA3 RNPS1 GRIN2B SPTBN4 SPTBN5 EPHA10 MYL12A SCN3B SCN3A SCN2A CD24 ADGRV1 SCN2B TRPC7 NRP2 TRPC5 VLDLR CAP1 TRPC6 RGMB TRPC3 GFRA3 RGMA MPZ TRPC4 RELN TRPC1 CAP2 ADGRG6 SCN9A NRCAM DSCAM DOK4 DOK5 DOK6 SCN8A EFNA5 HMGCR PITPNA EFNA4 SPTA1 EFNB2 EFNB1 EFNB3 CFL1 EFNA1 EFNA3 EFNA2 HJV SCN5A PAK2 GAP43 DCX SCN4A SCN4B SHANK3 MSN LAMA1 SCN7A PDLIM7 PSMD12 PSMD11 PSMD14 PSMD13 DRP2 RPLP1 PSMA7 RPLP0 PSMB6 PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 RPLP2 PSMB5 PSMD7 PSMB2 VASP PSMB3 UTRN PSMD2 PSMD3 PSMB1 PSMD1 ENAH EPHA4 ADRM1 PSMA5 SEM1 PSMA6 LYN PSMA3 PSMC5 PSMA4 PRX PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 MYH9 PSMC2 LAMA2 SH3KBP1 DLG1 EZR PRKCA PABPC1 RPL22L1 MYO10 RDX TIAM1 HSPA8 CDK5R1 PMP22 NAB1 EIF4G1 ITGA5 NAB2 PRKACG EGR2 CNTN1 PRKACB MAP2K1 MAP2K2 RBX1 MAPK1 MAPK3 NUMB PIK3CD SOS1 SPTBN2 PRKAR2A DAG1 WWTR1 YES1 HRAS YAP1 RASA1 NRAS PIP5K1C UNC5A UNC5B DCC UNC5C UNC5D LDB1 NTN1 RPL23A PIK3R3 ST8SIA4 NELL2 SLIT3 TEAD1 ELOB ELOC NCBP1 RPL27A NCBP2 WASL RPS6KA6 CXCR4 CNTN6 CHL1 ITGA2 ITGA10 ANK1 ITGA2B DLG3 NCAN PLXNA4 GRIN1 CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 CSNK2A1 DNM3 AP2S1 SH3GL2 CSNK2A2 ROCK1 CSNK2B RPL26L1 RPL4 ROBO2 RPL5 ITGB1 RPL30 RET RPL3 RPL32 EPHA2 RPL31 RPL34 RPL8 RPL6 RPL7 RPL36 SLIT2 RPL35 RPL38 TRIO RPL37 RPL39 ITSN1 GFRA1 RPL21 RPL23 GDNF RPL22 CACNA1H PSEN2 RPL24 PIK3R2 MYL6 RPL27 PIK3CB APH1A PIK3R1 APH1B RPL26 MYL9 RPL29 NGEF RPL28 SOX10 POU3F2 FRS2 PIK3CA ITGB3 RPL41 RPL3L ITGAV ARPC1B ARPC1A PSENEN SREBF2 ERBB2 PLCG1 EGFR SEMA5A PRKACA RPL10 HSP90AA1 RPL12 RPL11 RPL14 FARP2 RPL13 RPL15 RPL18 RPL17 RPL19 CXCL12 RPS15 RPS14 UBA52 RPS17 RPS16 RPS19 RPS18 RPS11 SHC1 RPS10 DOK2 PLXND1 RPS13 UBB RPS12 CACNB2 CACNA1D CACNB3 CACNA1C UBC RPS27A CLASP1 RPS4Y2 SDC2 RPS4Y1 FLRT3 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 RPS26 MAG ARPC5 RPS25 RPS28 RPS27 RPS29 ARPC2 RPL7A ARPC3 RPS20 RPS21 RPS24 PLXNB1 RPS23 NRP1 GRB10 MSI1 HOXA2 ISL1 RPL37A ADAM10 COL4A5 NCK2 GSPT2 GSPT1 UPF3A NCK1 LHX3 LHX2 ACTR3 LHX4 RPL36A LHX9 ACTR2 USP33 ROBO1 UPF2 ETF1 RPL35A PSEN1 ZSWIM8 SLIT1 EVL NCSTN SOS2 SRC ROCK2 COL9A1 COL9A3 COL9A2 LAMC1 RPS27L RPS15A GPC1 RPS3 RPS2 COL4A2 COL4A1 MMP2 COL4A4 COL6A2 FAU COL4A3 MMP9 AGRN PFN1 COL6A1 PFN2 GRB7 COL6A3 RPS9 COL6A6 RPS7 KALRN COL6A5 RPS8 MYL12B RPS5 SPTBN1 RPS6 RPSA PTK2 ANK3 RPL39L LAMB1 SPTAN1 GIT1 POU3F1 VAV3 RHOC ACTB VAV2 RHOB FYN ARHGEF7 RPL10L RPL10A HSP90AB1 RPS4X PAK1 RPS3A AKAP5 GAB2 PAK6 PAK3 PAK5 PAK4 SCD5 RANBP9 MYO9B SMARCA4 PTPN11 SDCBP ARHGAP39 ACTG1 TREM2 TYROBP RPL13A ARHGEF28 MYH14 MYH11 MYH10 CYP51A1 IRS2 DLG4 RND1 RPL18A ARHGEF11 RPL36AL ARHGEF12 CLTB PPP3CB CLTCL1 CLASP2 DPYSL4 LIMK2 DPYSL5 LIMK1 DPYSL2 DPYSL3 PLXNC1 ABL1 SEMA6A SEMA6D ITGA1 SEMA7A SEMA3A GAB1 CRMP1 MET SEMA3E RRAS PLXNA2 PLXNA3 SEMA4A CD72 CDK5 SEMA4D PTPRC FES PLXNB3 NEO1 GSK3B CACNB1 CACNB4 TLN1 MAPK7 ARHGAP35 RAC1 RHOA DOK1 DOCK1 SIAH2 SIAH1 CACNA1G RPL9P9 CACNA1I NRTN NCAM1 CACNA1S PRNP HDAC2 PSPN GFRA2 GFRA4 ARTN CNTN2 KIF4B KIF4A ST8SIA2 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes CYB5R2 CYB5R1 RHAG CYB5R4 CA1 CYB5RL AQP1 CA2 CA4 SLC4A1 HBA2 HBB DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system NAPEPLD OPN1LW OPN1SW LRAT RLBP1 OPN1MW RBP4 TTR RDH5 STRA6 RBP1 ABCA4 RDH12 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling MX2 MX1 IFNA21 PSMB8 IP6K2 IRF1 IRF5 PTPN6 IFNA5 IRF2 KPNA1 IFNA4 IFNA7 IFNA6 EGR1 IFNA1 IFNA2 IFI6 IRF3 IFNA8 ISG15 IRF7 JAK1 IFI27 USP18 ADAR IFITM3 IFITM2 IFIT5 TYK2 XAF1 IRF4 PTPN11 EIF2AK2 KPNB1 OASL OAS1 OAS3 ABCE1 SAMHD1 STAT1 IFNB1 STAT2 RNASEL IFITM1 UBA52 IFNA14 SOCS3 IFNA16 PTPN1 IFNA17 IFI35 UBB RSAD2 BST2 HLA-H UBC OAS2 HLA-B HLA-C GBP2 HLA-A RPS27A HLA-F HLA-G HLA-E IFNA10 IFNAR1 SOCS1 IRF8 IFIT1 ISG20 IFIT3 IFIT2 IRF6 IRF9 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation ADCYAP1 NTRK2 ADCYAP1R1 ADORA2A NTRK1 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation FGF23 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication H2AC14 H2BC21 H3-3B H2BC12L H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 KPNA6 KPNA1 H2AJ H2BC11 H4C9 H3C15 H2BC9 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX H2AC19 ORC5 KPNB1 ORC4 H2BC26 ORC6 H2AB1 ORC1 ORC3 H2AZ2 ORC2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling BLK CBFB RUNX1 PAX5 ELF1 ELF2 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids PI4KB SCD DBI THRSP CYP2R1 LSS THRAP3 VAC14 FAM120B NSDHL ABCD1 STARD3 STARD4 STARD5 STARD6 RUFY1 MTMR1 HACD1 MTMR2 MTMR3 ABCB4 MTMR8 MTMR9 HACD3 MTMR4 HACD2 MTMR6 HACD4 MTMR7 HSD11B1 UGT8 HSD11B2 HAO2 ABCA1 B3GALNT1 ARF3 ARF1 AACS ELOVL1 ELOVL4 ELOVL2 ELOVL3 ELOVL6 ELOVL7 PTGR1 PTGR2 SUMF2 SUMF1 BDH2 BDH1 PTGS2 PTGS1 PCCA PCCB ACACB ACACA GC GK FABP9 FABP1 FABP2 FABP3 FABP5 FABP6 MAPKAPK2 FABP7 PECR HPGDS OSBP KPNB1 CYP19A1 ACAT2 ACAT1 SLCO1B1 PMVK PRKACG SLCO1B3 THEM5 PRKACB THEM4 HACL1 SRD5A2 SRD5A1 SRD5A3 B3GALT4 SLCO1A2 FHL2 PIK3CD PIK3CG ME1 ARNT SLC25A17 SCP2 ST6GALNAC5 ST6GALNAC6 PRKAB2 PPM1L CH25H HSD17B14 HSD17B13 LRP2 FAR1 HSD17B12 HSD17B11 FAR2 CLOCK SLC25A20 AGMO PIP5K1A CYB5B PIP5K1B PIP5K1C LTA4H MMAA GSTM4 CYP4F2 CYP4F3 CYP4F8 PRXL2B ACOT7L LGMN MTMR10 MTMR12 ACAD11 MTMR14 ACAD10 PRKAG2 ARSA MED19 MED15 MED18 SMPD3 SMPD2 MED11 SMPD4 SMPD1 TSPO PIK3R3 PIK3R6 PIK3R5 ARSL SPHK2 ARSJ MED26 ARSK ARSH MED29 ARSI MED28 ST8SIA5 MED22 ARSF ARSG MED25 ARSD CYP21A2 HMGCLL1 MED21 CTSA AGPS ACER2 ACSBG1 ACER1 ACSBG2 ACER3 RGL1 MOGAT3 MOGAT2 MOGAT1 PPARD TECR AKR1B1 SAMD8 ARV1 SPTLC1 ACADL ABCB11 SPTLC2 SPTLC3 ACADM ACADS CRAT STARD3NL SLC27A1 FADS2 AKR1D1 RXRB NUDT19 PLEKHA1 PLEKHA2 FADS1 AKR1C1 PLEKHA5 AKR1C3 AKR1C2 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 ACLY PLEKHA8 PPP1CA SLC27A3 SLC27A2 SLC27A5 ACAA2 CYP46A1 GGT1 RAN NRF1 ACAA1 CYP2C19 SBF1 PIAS4 SBF2 NPAS2 HEXB DPEP2 HEXA DPEP1 UBE2I VDR NR1H2 GLB1L3 RORA GLB1L2 KDSR FUT2 FUT1 GLB1L GLB1 BMX EBP RXRA CYP11A1 ARSB SP1 SUMO2 PPARG TBXAS1 PPARA GGT5 FDPS ECHS1 OSBPL1A LPGAT1 ALAS1 PITPNB CYP11B2 PTEN CPNE7 CYP11B1 CPNE6 LCLAT1 PLB1 CHD9 LIPI LIPH CPNE1 CPNE3 MFSD2A MIGA2 CPT2 DGAT2 PCYT2 A4GALT CSNK2A1 DGAT1 CERS3 CERS4 MIGA1 STARD7 CERS5 CSNK2A2 CERS6 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 CSNK2B GPD1 PLA2G10 PGP TNFRSF21 PLBD1 CERS1 PLA2R1 CERS2 PLA1A CDS1 MVD ABHD4 ABHD3 PRKAA2 CHAT PLA2G3 MVK PLD4 PLD6 PLA2G5 PLA2G6 PLD1 HMGCL AWAT1 PLD3 PLD2 MBTPS1 TSPOAP1 PGS1 PTDSS2 MID1IP1 PTDSS1 CYP24A1 PTPMT1 CYP4B1 MBTPS2 OSBPL8 TMEM86B CHKB CHKA OSBPL5 STARD10 CERK DGAT2L6 ECI1 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE STS SLC44A3 SLC44A4 MFSD2B SLC44A1 SLC44A2 LPCAT1 FDXR PCTP OSBPL10 CYP39A1 PIP4K2A ACP6 PLA2G4F PLA2G12A CYP1B1 TRIB3 PCYT1B PIP4K2B PCYT1A PLA2G4D PIP4K2C PLA2G4E MMUT PLA2G4B NEU2 PLA2G4C NEU3 PLAAT1 SULT2A1 PLA2G4A ACOT9 PLAAT3 CUBN NEU1 PLAAT2 ACOT8 B4GALNT1 GPCPD1 MECR PLAAT5 ACOT7 DECR2 PLAAT4 HADHB HADHA DECR1 PITPNM1 PITPNM3 MED8 PITPNM2 MED9 MGLL SLC10A1 SLC10A2 AGPAT5 MED13L TAFAZZIN FDX1 PLA2G1B FDX2 AGPAT1 ACOT2 AGPAT2 ACOT1 AGPAT3 PIK3R2 SELENOI AGPAT4 PIK3CB AWAT2 GPAT4 PIK3R1 GPAT3 GPAT2 CEPT1 ACOT4 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PIK3CA PLA2G2A DDHD2 MBOAT1 MBOAT2 CDK19 DDHD1 CROT ETNPPL GPAM LPCAT4 ETNK2 FA2H LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 SREBF1 GPD1L CYP1A1 LPIN1 LPIN2 SREBF2 LPIN3 CYP2C9 PNPLA2 CYP2C8 CYP2D6 SERPINA6 HSD17B3 EPHX2 ALOX5 HSD17B4 CYP1A2 FITM1 CYP2E1 PIP4P1 FITM2 CYP3A4 HSD17B7 HSD17B8 LDLRAP1 PPP1CB CYP17A1 BAAT ORMDL2 HSD17B1 ORMDL3 HSD17B2 PRKACA PNPLA7 ORMDL1 CYP8B1 ASAH1 NUDT7 ASAH2 NDUFAB1 PNPLA4 PNPLA5 PNPLA6 SC5D INPPL1 MSMO1 ENPP6 ENPP7 TPTE2 ACOT11 ACOT12 ACOT13 AGT FIG4 AHR FABP12 DHRS7B SAR1B ABHD5 CYP4F22 DEGS1 PIK3R4 DEGS2 PSAP TNFAIP8 ESRRA CYP4A22 ST3GAL2 ACOXL ST3GAL3 DHCR24 TECRL CYP4F11 ALB DHCR7 CYP4A11 ACOX2 ACOX3 GM2A GPX2 GPX1 GPX4 GK3 GK2 OXCT1 TGS1 OXCT2 HSD3B7 HSD3B2 HSD3B1 TXNRD1 PTPN13 GALC CARM1 GLA FAAH PI4K2B ACSM3 GDE1 ACSM6 PRKD3 PRKD2 PTGDS PRKD1 SACM1L PI4K2A ACSL6 ACSL5 CYP27A1 INPP4A INPP4B PLPP6 PLPP3 PLPP2 ST3GAL5 PLPP1 CGA PTGES FDFT1 NR1D1 MCAT SQLE CYP27B1 PPT1 SGPL1 PPT2 INPP5F INPP5D INPP5E INPP5J INPP5K SCAP HTD2 MCEE CIDEA ALOX15B STAR MTF1 AKR1B15 AHRR HILPDA PLIN3 SGMS1 GLIPR1 SGMS2 CCNC ANKRD1 TNFAIP8L1 LIPE TNFAIP8L3 TNFAIP8L2 NR1H4 CAV1 NR1H3 G0S2 MED1 ACSL1 B3GNT5 MED4 MED6 MED7 TM7SF2 PPP1CC PEX11A ALOX12B PPARGC1A PPARGC1B CREBBP OLAH PIK3C3 ARNT2 CSNK1G2 SCD5 INSIG2 SEC23A INSIG1 MTM1 CIDEC BMAL1 OSBPL9 SEC24B SEC24A OSBPL7 SPNS2 RAB4A OCRL OSBPL6 OSBPL3 OSBPL2 M6PR ABCG2 SYNJ2 SEC24D SYNJ1 SEC24C RAB5A MED16 GAL3ST1 ALDH3B2 MED17 ALDH3B1 MED12 ACBD7 MED14 PIK3C2G MED13 PIK3C2A ACBD6 MED10 ACBD5 PIK3C2B CD36 ACBD4 HMGCS2 NCOA1 ACSF3 LBR NCOA2 ACSF2 ELOVL5 NCOA6 GGPS1 NCOA3 HMGCS1 APOA2 ACADVL FAAH2 GBA1 ABCD3 APOA1 MED27 MED23 NCOR2 APOA5 TPTE MED24 NCOR1 MED20 PLIN2 UGT1A9 ABCC3 ANGPTL4 ABCC1 PLIN1 ALOXE3 GPS2 PTGIS TBL1X CYP51A1 RAB14 VAPA EHHADH VAPB B4GALT6 B4GALT5 PON3 HPGD GBA3 PON2 GBA2 PON1 FABP4 LTC4S SGPP2 EP300 SGPP1 POMC SPHK1 CPT1A PIKFYVE SLC51A SLC51B CPT1B ALOX5AP TIAM2 CYP2U1 SLC22A5 TBL1XR1 LHB HELZ2 UGCG MED30 MED31 CBR1 MORC2 CYP7B1 CDK8 GDPD1 GDPD3 GDPD5 CYP7A1 SPTSSB SPTSSA CBR4 SIN3A NFYA NFYB PTGES2 NFYC PTGES3 GRHL1 HADH PHYH IDI1 ACSS3 IDI2 ALOX15 HDAC3 ALOX12 SMARCD3 CYP2J2 FASN ACSL4 AMACR ACSL3 PI4KA SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions SLCO2B1 SLC16A2 SLC13A5 SLCO1B1 SLC13A2 SLC13A3 SLCO1C1 SLC22A12 SLCO1B3 SLCO4A1 SLC16A7 EMB SLC16A1 BSG SLCO1A2 SLC16A8 SLC5A7 SLC16A3 SLC10A6 AVP SLC44A5 SLCO4C1 SLC44A3 SLC44A4 SLC44A1 SLCO2A1 SLC44A2 SLC25A10 SLC25A11 SLC22A8 SLC5A8 SLC17A5 SLC25A1 SLC22A6 SLC5A12 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs FLT3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD PSMA5 SEM1 SHH PSMA6 SYVN1 PSMA3 DERL2 PSMC5 PSMA4 PSMC6 OS9 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ERLEC1 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 SEL1L PSMB3 PSMD2 VCP PSMD3 PSMB1 PSMD1 ADRM1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis RFC5 RFC3 RFC4 RFC2 PRIM2 RFC1 PRIM1 POLA1 POLA2 PCNA POLD3 POLD1 POLD4 POLD2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport LETM1 STOML2 PHB1 MCUB SPG7 PHB2 VDAC3 MAIP1 VDAC2 PARL AFG3L2 SMDT1 SLC8B1 YME1L1 VDAC1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU SLC8A3 AKAP1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway RXRG ESRRA THRB MED1 RARB VDR NR1H2 RORA ESR1 NR2C1 NCOR2 NR5A1 NR4A2 AR PPARD RXRA NR1D1 NCOR1 RARA PPARG ESRRB PGR ESRRG PPARA HNF4A RXRB ESR2 NR2F1 NR4A1 THRA RORC NR0B2 NR2E1 RORB NR2F6 NR2C2AP NR1D2 NR2C2 HNF4G NRBP1 RARG PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria PAH DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o DPM1 DPM2 DPM3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes KANSL1 MEN1 KANSL2 KANSL3 WDR5 KAT8 NCOA6 KDM6A HCFC2 KMT2D HCFC1 PHF20L1 KMT2A KAT2B WDR82 KMT2C KAT2A PAXIP1 KMT2B BOD1L1 MBIP KAT14 TASP1 DR1 SETD1B BOD1 SETD1A CXXC1 TADA2A MCRS1 ZZZ3 YEATS2 TADA3 RBBP5 OGT PHF20 AKAP8L PSIP1 DPY30 ASH2L SGF29 PAGR1 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis CHST14 DSEL CSPG5 UST DCN NCAN BGN VCAN DSE CHST15 BCAN RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB APEX1 LIG3 XRCC1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation DYNC1LI1 DYNC1LI2 NUP37 CDCA8 ITGB3BP NDC80 SKA1 RPS27 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B BUB1 CLASP2 XPO1 SPDL1 DYNC1I1 CENPE NUF2 NUDC NUP160 DYNLL2 NUP85 BIRC5 NEK9 NEK6 NEK7 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L NSL1 ZWILCH CENPA PPP2R5B PPP2R5A PPP2R5D CENPC PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E KNTC1 CENPT CENPU SEC13 SGO1 SGO2 NUP133 DYNLL1 CKAP5 CENPF KNL1 ZW10 CENPH RANGAP1 MAPRE1 PMF1 CENPI TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO DSN1 CENPP CENPQ CENPS BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 NUP43 KIF18A CLASP1 RANBP2 DYNC1H1 NDE1 EML4 PLK1 CLIP1 NDEL1 MAD1L1 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly MTTP P4HB APOB APOE SAR1B APOC3 APOA2 APOC2 APOA1 APOA4 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 FGF1 NRAS FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF2 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs H2AC12 H2AC14 EP300 NLRP3 H2AC8 ABRAXAS2 MYSM1 H2AC6 BRCC3 STAMBPL1 H2AC7 STAMBP BABAM1 BABAM2 UIMC1 ABRAXAS1 H2AC25 H2AC21 KAT2B UBA52 UBB STAM PSMD14 UBC BARD1 RPS27A H2AC20 H2AC19 BRCA1 H2AC1 H2AC17 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis MYB MCIDAS E2F5 CCDC78 GRHL1 RFX2 RFX3 CCNO GRHL3 GRHL2 TNRC6C DEUP1 MOV10 AGO3 AGO4 AGO1 AGO2 GMNC TNRC6A TNRC6B FOXJ1 NOTCH1 DLL1 TFDP1 E2F4 TP73 GMNN BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism NCOA1 SLCO1B1 NCOA2 SLC51A SLC51B SLCO1B3 NR1H4 ALB CYP27A1 ABCD3 ACOX2 SLCO1A2 RXRA ABCB11 ABCC3 HSD3B7 OSBPL1A CYP7B1 CYP39A1 HSD17B4 AKR1D1 FABP6 OSBPL9 OSBPL7 OSBPL6 CYP7A1 AKR1C1 OSBPL3 OSBPL2 BAAT AKR1C3 OSBP ACOT8 STARD5 AKR1C2 AKR1C4 CYP8B1 CH25H SLC10A1 AMACR SLC27A2 SLC10A2 SLC27A5 CYP46A1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions RNF19B JAK2 HEYL MYC SOX10 MYCN TNRC6C JUP MOV10 CDH5 AGO3 AGO4 AGO1 AGO2 CDC42 CDH11 TNRC6A TNRC6B STRAP TFAP2A PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 POMT2 RELA POMT1 FARP2 VCL NFKB1 IL6 TRAF7 UBA52 ZNF217 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 MOGS PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 RPN1 PSMB1 PSMD1 ADRM1 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 ZMYM2 JAK1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 TYK2 SRC PCSK6 TIAM1 CANX CTSS CTSL CTSB MAPK1 MAPK3 FURIN PCSK7 CSNK2A3 ANK3 TMEM258 KMT5A RB1 H2AC19 H2AC14 VAV2 H2BC12L OST4 ARHGEF4 OSTC STT3A PVR MDM2 PIP5K1C PRKCSH TCF3 SNAI1 DDOST SNAI2 CTNNA1 TGIF2 DAD1 H4C9 SMARCA4 GANAB H2AC20 NECTIN2 FOXQ1 DNTTIP1 EZH2 ZBTB33 H2AX FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 H3-3B H3C8 TCF12 SIRT1 ZC3H12A H2AJ ANG CADM3 CADM1 CADM2 ANGPTL4 H3C15 SUZ12 H2BC9 H2BC8 H2BC5 ARHGAP32 H2BC3 ADAM33 H2BC1 CDH9 IL6ST CDH8 CDH7 CDH6 CDH3 IL6R ADAM19 MPHOSPH8 CDH24 H2AB1 CDH10 CDH12 CDH13 CDH17 CDH18 CDH19 NECTIN4 H2AC8 NECTIN3 NECTIN1 H2AC6 H2AC7 CTBP2 CTBP1 SP1 CDH4 SEC11A CDH2 SEC11C DNM2 CSNK2A1 FOXA2 CSNK2A2 CDH15 CSNK2B H2BC26 KLF4 H2BC21 KDM1A RAC1 TWIST2 EED TWIST1 ARID1A SPCS3 H2BC17 SPCS2 XIAP SPCS1 H2BC12 H2BC13 H2BC14 H2BC15 ELMO1 DOCK1 HACE1 H2BC11 BIRC2 TLE1 HDAC2 HDAC1 RBBP4 RBBP7 WT1 H2AZ2 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis PPCDC PPCS PANK2 PANK3 PANK1 DCAKD COASY AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PSMA5 ERLIN2 CD274 SEM1 PSMA6 PSMA3 DERL2 PSMC5 PSMA4 RNF5 PSMC6 OS9 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 RNF185 PSMC2 PRKAB1 PRKAG2 PRKAA1 SEL1L DERL3 PRKAG1 DERL1 PRKAG3 PRKAA2 ERLEC1 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PRKAB2 PSMB2 PSMB3 PSMD2 PSMD3 VCP PSMB1 PSMD1 ADRM1 ERLIN1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 CTBP2 PSMC2 CTBP1 CTNNB1 TLE5 ZRANB1 PPP2R1A GSK3B BTRC AMER1 AXIN1 PPP2R5B PPP2R5A TCF7L1 PPP2R5D PPP2R5C SKP1 PPP2CA PPP2CB FRAT1 FRAT2 APC PPP2R1B TCF7L2 PPP2R5E RBX1 UBA52 TLE4 TLE3 TLE2 CUL1 TLE1 PSMD12 CSNK1A1 PSMD11 UBB TCF7 PSMD14 HDAC1 PSMD13 LEF1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) DAXX ATRX SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT KIT G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events GNAT3 ADRA2B GNAZ GNAI3 ADCY9 RGS17 GNG3 RGS19 RGS16 GNG2 GNG5 ADCY4 GNG4 GNG7 ADRA2C ADCY3 ADRA2A ADCY2 GNG8 ADCY1 ADCY8 ADCY7 RGS20 ADCY6 ADCY5 RGSL1 GNG10 PRKCD PRKCA PRKCH RGS4 GNG12 GNAS PRKCE GNG11 GNG13 GNB2 GNAI1 PRKCQ GNAI2 GNB1 GNB4 GNB3 GNB5 PRKCG GNGT1 GNGT2 PRKCB CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) EBP DHCR24 SC5D DHCR7 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors LTB4R2 GPR17 LTB4R CYSLTR1 CYSLTR2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol CALM1 INPPL1 PLD4 PLCG2 PLCZ1 PLCD3 PLCD4 PLCD1 INPP5B INPP5D PLCH1 INPP5J PLCH2 PTEN PLCG1 PLCE1 OCRL ITPK1 ITPKB ITPKC PLCB3 SYNJ1 PLCB4 ITPKA PLCB1 PLCB2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity HGF PTPN1 PTPN2 HGS UBB MET STAM PTPRJ UBC EPS15 STAM2 RPS27A SH3KBP1 LRIG1 SH3GL2 UBA52 SH3GL3 USP8 CBL SH3GL1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation ALDH2 ALDH1A1 ACSS1 ADH1C ADH7 ADH1B ADH1A ADH5 ADH6 ADH4 ALDH1B1 ACSS2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions DSCAM DCC NTN1 DSCAML1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking CFTR GOPC RHOQ VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins PRKACG PRKACB ADCY9 PRKAR1B GNG3 PRKAR1A GNG2 GNG5 ADCY4 GNG4 GNG7 ADCY3 ADCY2 GNG8 ADCY1 ADCY8 ADCY7 AVP ADCY6 ADCY5 PRKAR2A GNG10 PRKAR2B AVPR2 GNG12 GNAS GNG11 GNG13 RAB11A GNB2 GNB1 AQP4 AQP2 GNB4 AQP3 GNB3 AQP1 GNB5 PRKACA GNGT1 RAB11FIP2 GNGT2 MYO5B ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins DEFA5 DEFA3 ART1 PRSS2 CD4 DEFA1B PRSS3 DEFA6 DEFA4 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP H2BC14 H2BC15 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 MPG H2BC1 H2AX H2AC19 H2BC26 NEIL3 H2AB1 H2AZ2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway EP300 IKBKE TRIM25 MAVS RIGI IFNB1 SIKE1 TBK1 IRF3 TRAF3 CREBBP RNF135 TRIM4 IFIH1 IRF7 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants NRAS NF1 SPRED3 SPRED2 SPRED1 HRAS SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation SLC15A4 IKBKB TASL IRF5 IKBKG CHUK SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) PTPRS IRS1 NELFB NRAS PIK3R1 PLCG1 SRC PIK3CA NTF3 PTPRO SOS1 BAX HRAS NTRK3 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin SHC1 LYN GAB1 PIK3CB NRAS PIK3R1 JAK2 PLCG1 RAPGEF1 PLCG2 IRS2 CRKL PIK3CA EPO STAT5A STAT5B EPOR PIK3CD PIK3R5 SOS1 PIK3CG HRAS VAV1 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII SHC1 GAB1 CDC37 EGF NRAS PIK3R1 PLCG1 EGFR PIK3CA SOS1 HRAS CBL HSP90AA1 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network GOLGA4 NSF GCC2 RAB9A RAB9B RAB6B M6PR VAMP3 COG1 RAB6A VAMP4 NAPA TGOLN2 USP6NL SCOC SYS1 GCC1 RAB43 GOLGA1 ARFIP2 IGF2R ARL1 RABEPK NAA30 NAA35 NAA38 TMF1 STX10 RIC1 ARFRP1 VPS51 STX16 VPS53 RGP1 VPS52 VPS54 PLIN3 STX6 NAPB VTI1A COG8 COG7 COG6 COG5 RHOBTB3 NAPG COG4 COG3 COG2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling TGFBR1 TGFBR2 MTMR4 BAMBI PPP1CC STUB1 UBA52 PMEPA1 TGFB1 XPO1 SMAD2 UBB UCHL5 NEDD4L SMAD3 SMURF2 STRAP PPP1R15A UBC SMURF1 USP15 SMAD7 RPS27A PPP1CB PPP1CA GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) CALM1 GAA PYGB GYG2 GYG1 PYGM PYGL PHKG1 AGL PHKG2 PGM1 PHKB AKR1E2 PHKA1 PHKA2 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation NPAS4 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose PMM1 HK1 GMPPB GMPPA PMM2 MPI DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity CDK4 CCND3 CCND2 CDK6 CCND1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins ATP6AP2 ENPEP CPB1 CTSG ACE CMA1 CTSD GZMH CES1 REN ACE2 AGT CPB2 MME CTSZ ANPEP CPA3 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development HEY2 GLI3 GLI2 HDAC4 IHH MAPK1 BGLAP MAPK3 AR RBM14 ABL1 CBFB HDAC3 SMAD1 SMAD4 SMAD6 ZNF521 MAF SRC HDAC6 COL1A1 SP7 RB1 WWTR1 YES1 UCMA HES1 YAP1 SATB2 HEY1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry ACE2 CTSL VCP TMPRSS2 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells PTF1A ONECUT3 HNF1B ONECUT1 NKX6-1 PDX1 FGF10 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses RPS6KA3 RPS6KA2 RPS6KA1 BCHE MYO6 GRIN2A GRIN2B GNAI1 GNAI2 PRKX TOMT PLCB3 PRKACA PLCB1 PLCB2 SLC18A3 SLC6A3 PRKAR2B SLC1A1 CACNA1A CACNB2 SLC1A2 CACNB3 SLC1A3 CACNA1E SLC1A6 SLC1A7 SLC38A2 SLC38A1 LIN7B SLC6A4 VAMP2 GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA2 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 PRKAB1 SLC5A7 RASGRF2 DNAJC5 GLS2 PRKCA SRC GLS HSPA8 PRKAG1 PRKAG3 GLUL PRKACG SLC6A12 SLC6A11 PRKACB SLC32A1 SLC6A13 ABAT SLC6A1 ALDH5A1 MAPK1 ADCY9 PRKAR1B MAPK3 PRKAR1A MAOA ADCY4 ADCY3 ADCY2 KPNA2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A UNC13B PRKAB2 RAB3A SYT1 SYN3 GIT1 SYN2 CACNA2D2 CPLX1 SYN1 RIMS1 PPFIA1 HRAS PPFIA4 SLC18A2 PPFIA3 PPFIA2 GNAT3 ARHGEF9 GAD1 GAD2 NRAS GNAI3 ARL6IP5 NAAA MDM2 PDPK1 AKAP5 PRKAG2 CAMK1 CAMKK1 CAMKK2 PRKAA1 STX1A SLC22A2 SLC22A1 CALM1 SLC17A7 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRNA5 CHRNA4 CHRNA6 ALDH2 RPS6KA6 ACTN2 CASK GABRG3 GABRG2 CHRNA7 CHRNA9 GNG10 LIN7A LIN7C GRIN2C GRIN2D GRIN3B GNG12 GNAL GNG11 DLG2 GNG13 GRIN3A DLG3 NBEA GNB2 GABRB3 GABRB2 GNB1 GABRB1 GRIK5 DLG4 GNB4 RASGRF1 GRIK3 GNB3 GRIK4 GRIK1 GNB5 GRIK2 NRGN PRKCG GABRR3 GNGT1 GABRR2 GABRR1 NPTN GNGT2 NEFL HTR3E HTR3C HTR3D HTR3A HTR3B LRRC7 PPM1E NCALD PPM1F GLRA1 CHRND GLRA2 GLRA3 CHRNG CHRNE KCNJ2 KCNJ3 GABRA2 GABRQ KCNJ4 GABRA1 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GABBR1 GNG5 GNG4 KCNJ10 GABRA6 GNG7 GABRA5 GNG8 KCNJ12 KCNJ9 GABRA4 KIF17 GABRA3 KCNJ15 KCNJ16 GRIN1 GLRB APBA1 SNAP25 AP2A1 CACNG8 CACNB1 CACNG2 CACNB4 CACNG3 CACNA2D1 CACNG4 CACNA2D3 CACNA1B CHAT PRKAA2 RAC1 NRG1 TSPOAP1 COMT CAMK4 ACHE CAMK2B CAMK2D CAMK2A CAMK2G PRKCB RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation FURIN PPP1CB SPCS3 SPCS2 SEC11A SPCS1 SEC11C HSP90AB1 CSNK2A1 PPP1CC CSNK2A2 HSPA8 PPP1CA KPNB1 CSNK2B HSP90AA1 XPO1 SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste OTOP1 KCNJ2 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 GCKR GCK NUP35 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis ESRRA CRTC1 NRF1 SIRT3 MED1 MEF2C ATF2 TBL1XR1 HCFC1 HELZ2 RXRA PPARGC1A PPARGC1B PPARA ATP5F1B GLUD1 TGS1 GLUD2 CREBBP ACSS2 ALAS1 CYCS CHD9 CARM1 CRTC2 CRTC3 MEF2D CALM1 NCOA1 NCOA2 MTERF1 NCOA6 TFAM TFB1M GABPA TFB2M PPRC1 NR1D1 POLRMT NCOR1 SOD2 POLG2 CAMK4 TWNK PERM1 SSBP1 TBL1X HDAC3 SMARCD3 IDH2 SIRT4 SIRT5 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 TBP GTF2B GTF2A1 GTF2F1 GTF2A2 GTF2F2 TAF9 TAF1L POLR2A POLR2B POLR2C GTF2E1 POLR2D GTF2E2 CDK7 POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH TAF8 POLR2K POLR2L TAF4B TAF7 TAF6 TAF7L TAF5 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs HPGD ALOX15 LTA4H ALOX5 PTGS2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 L1CAM MAPK1 NUMB MSN DPYSL2 RPS6KA4 RPS6KA6 EZR SHTN1 CLTC CLTA AP2A1 AP2B1 KIF4B AP2A2 KIF4A DNM1 DNM2 DNM3 AP2S1 SH3GL2 RDX COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport CAPZB GOSR2 DYNC1LI1 DYNC1LI2 GOLGA2 FOLR1 BET1 NSF SPTB DYNC1I1 KDELR1 CAPZA1 CAPZA2 ANK2 ARFGAP3 CD59 CD55 ARFGAP2 TMED2 DYNLL2 SPTBN4 ACTR1A SPTBN5 COG1 COPB1 NAPA STX5 YKT6 ARF4 SPTA1 TMEM115 INS DYNLL1 DCTN1 KDELR2 COPB2 COPA GOLGB1 SPTBN2 DYNC1I2 COPE ARFGAP1 DCTN2 TMED3 TMED7 DCTN3 TMED9 RAB1A COPZ2 RAB1B COPZ1 SPTBN1 ARF5 ARF3 ANK3 ARF1 ANK1 KDELR3 CAPZA3 GBF1 ACTR10 GOSR1 ARCN1 DYNC1H1 COPG2 GORASP1 COPG1 SPTAN1 NAPB TMED10 COG8 COG7 DCTN6 COG6 DCTN5 USO1 COG5 DCTN4 NAPG COG4 COG3 COG2 BET1L DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade F2 F5 F8 F9 VWF ANO6 F10 F11 GP5 GP9 PROC PROS1 GGCX GP1BA TPST2 TPST1 FGB FGA GP1BB FGG KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization JUP KRTAP27-1 KRTAP5-10 KRTAP5-11 KRTAP16-1 KRTAP25-1 KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRTAP4-4 KRTAP4-3 KRT1 KRTAP4-2 KRTAP4-1 KRTAP4-9 KRTAP4-8 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP29-1 KRTAP6-2 KRTAP6-1 KRTAP6-3 KRTAP8-1 KRTAP23-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP12-4 KRTAP10-1 KRTAP21-2 KRTAP21-3 KRTAP10-3 KRTAP10-2 KRTAP10-5 PI3 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP21-1 KRTAP17-1 KRTAP4-11 KRTAP26-1 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP15-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 KRT4 KRT3 KRT2 KRT8 KRT7 KRT5 KRT9 KRTAP20-1 KRTAP20-2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRT33B KRT33A KRT24 KRT23 KRT20 KRT28 KRT27 KRT26 KRT25 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP9-2 KRTAP9-1 KRT35 KRT34 CAPNS1 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 KRT13 CAPN1 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 KRT14 KRTAP24-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 KRT78 KRT77 KRT76 KRT75 DSG2 KRT74 KRT73 KRT72 KRT40 KRTAP22-1 TCHH KRTAP11-1 PCSK6 KRT82 TGM1 KRT81 LCE1A KRT80 CASP14 KRT86 LCE1B KRT85 LCE5A KRT84 LIPJ LIPN LIPM PRSS8 LIPK TGM5 RPTN CELA2A SPINK6 SPINK5 KAZN LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A LCE6A PKP2 PKP1 LORICRIN PKP3 SPINK9 PERP DSG3 DSG4 DSC1 DSC2 IVL DSC3 FLG SPRR2E SPRR2F SPRR3 CSTA SPRR2G KLK5 KLK8 PPL EVPL LCE2D LCE3C LCE3D LCE3A LCE3B FURIN LELP1 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK13 KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B DSP DSG1 PKP4 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds FDX2 CYP26A1 NR1H4 CYP2R1 CYP3A43 CYB5B HSP90AB1 ALDH1A1 CYP4F2 CYP4F3 CYP4F8 ALDH1B1 ARNT2 CYP1A1 NQO2 CYP2C9 CYP2C8 CYP2D6 CYP1A2 CYP2E1 CYP3A4 ALDH3A1 CYP8B1 EPHX1 NCOA1 NCOA2 CYP21A2 AOC3 AOC1 AOC2 FMO1 FMO2 ALDH2 FMO3 CYP4V2 BPHL CYP3A5 CYP3A7 CYB5R3 CYP2B6 AHR PTGIS CYP51A1 AIP CYP2A13 CYP4F22 CYP46A1 CYP4A22 POMC CYP26B1 CYP2C19 CYP2C18 CYP4F11 CYP4F12 POR CYP2U1 CYP4A11 CYP26C1 PTGS1 CYP11A1 RXRA CYP2F1 TBXAS1 CYP2S1 ACSS2 CYP7B1 CYP11B2 ACSS1 CYP11B1 ADH1C AADAC ADH1B ADH1A CYP7A1 CBR3 CYP19A1 ADH7 PAOX PTGES3 CMBL CYP27A1 ADH5 CYP2W1 ADH6 ADH4 CYP24A1 CYP4B1 MTARC2 MAOB MTARC1 MAOA CYP27B1 ARNT FDXR CYP39A1 CYP2A7 CYP2A6 CYP1B1 CES3 CYP2J2 CES2 CES1 AHRR FDX1 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants CALM1 VCL NRAS JAK2 ARRB2 MAP2K1 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 ITGB3 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG RAP1B VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 CAMK2B CAMK2D CAMK2A CSK HRAS CAMK2G TLN1 FN1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma RHOA GNG3 GNG2 GNG5 GNG4 GNG7 PDPK1 GNG8 PIK3CG AKT2 AKT3 AKT1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 PIK3R6 PIK3R5 GNGT1 GNGT2 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation ELOA ERCC3 NELFB ELOB NELFCD NELFA ELOC ERCC2 NELFE NCBP1 NCBP2 CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E GTF2H5 POLR2F ELOA2 POLR2H SUPT5H CDK9 CCNH SSRP1 POLR2K POLR2L TCEA1 ELL CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators MBL2 COLEC11 C1QB C1R C1QC C1S IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 FCN1 V5-4 FCN2 V1-7 FCN3 V5-1 V1-5 CRP V1-3 COLEC10 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1QA MASP1 IGHG3 IGHG4 IGHG1 IGHG2 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER GOSR2 MIA2 STX5 CNIH1 MIA3 CNIH2 FOLR1 CNIH3 SEC22B GRIA1 CTSZ F5 SEC23A CTSC F8 AREG CD59 PREB TMED2 SEC24B SEC24A MCFD2 TGFA SERPINA1 COL7A1 LMAN1L SEC24D SAR1B SEC24C TMED10 LMAN2L LMAN1 LMAN2 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation MRPL18 MRPS33 MT-CO2 MRPL19 MRPS34 MT-CO3 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MT-ATP6 MRPL22 MRPL30 MALSU1 MT-ND6 MIEF1 MT-ND4 MTFMT MT-ND5 MTIF2 MTIF3 MT-ND2 MTRFR MT-ND3 MTRES1 MT-ND1 OXA1L MT-ATP8 NDUFAB1 KGD4 MT-CYB MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MT-ND4L TUFM MRPS23 MTRF1 MRPL49 MRPS18B GFM2 MT-CO1 MRPS18A MRRF MRPS21 MTRF1L MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome CALM1 NCOR2 GPS2 TBL1X HDAC3 HDAC1 PRKACA NCOR1 CAMK4 TBL1XR1 SIN3A DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) STAT3 ELOB LYN SYK ELOC JAK2 HCK STAT1 CSF3 UBA52 UBE2D2 RNF7 CUL5 GAB2 SOCS3 CSF3R JAK1 KRAS SHC1 UBB UBC GRB2 TYK2 RPS27A UBE2D3 PTPN11 STAT5A SOCS1 UBE2D1 STAT5B FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation CEACAM6 CEACAM8 ITGB1 CEACAM1 FN1 ITGA5 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids FDX2 LRP2 HSD17B12 SCD HSD17B11 NR1H4 MED1 CYP2R1 LSS TM7SF2 GPAM CREBBP SREBF1 SREBF2 LGMN INSIG2 SEC23A INSIG1 SERPINA6 HSD17B3 HSD17B4 OSBPL9 HSD17B7 SEC24B SEC24A OSBPL7 NSDHL LDLRAP1 OSBPL6 OSBPL3 CYP17A1 STARD3 OSBPL2 BAAT STARD4 HSD17B1 STARD5 STARD6 TSPO HSD17B2 SEC24D SEC24C CYP8B1 NCOA1 LBR NCOA2 SC5D CYP21A2 MSMO1 NCOA6 GGPS1 HMGCS1 ABCD3 AKR1B1 HSD11B1 ARV1 HSD11B2 ABCB11 ABCC3 TBL1X STARD3NL CYP51A1 AKR1D1 AKR1C1 AKR1C3 AKR1C2 SAR1B AKR1C4 SLC27A2 SLC27A5 ELOVL6 CYP46A1 POMC RAN SLC51A DHCR24 SLC51B PIAS4 ALB UBE2I DHCR7 VDR TBL1XR1 ACOX2 LHB EBP HELZ2 CYP11A1 RXRA ACACB ACACA SP1 SUMO2 GC PPARA FDPS TGS1 OSBPL1A HSD3B7 CYP7B1 CYP11B2 HSD3B2 CYP11B1 HSD3B1 CHD9 FABP6 CYP7A1 CARM1 OSBP KPNB1 CYP19A1 ACAT2 NFYA NFYB SLCO1B1 MVD PMVK NFYC SLCO1B3 MVK CYP27A1 SRD5A2 PLPP6 SRD5A1 SRD5A3 MBTPS1 TSPOAP1 CYP24A1 MBTPS2 CGA SLCO1A2 FDFT1 SQLE CYP27B1 STS IDI1 IDI2 FDXR SMARCD3 CYP39A1 SCAP STAR AKR1B15 MTF1 CUBN ACOT8 FASN CH25H SLC10A1 AMACR SLC10A2 FDX1 HSD17B14 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SKP2 PTTG1 AURKB NEK2 BTRC ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC14A UBA52 CUL1 AURKA PSMD12 CCNB1 BUB1B PSMD11 UBB CDC20 FBXO5 PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 RB1 PSMB3 PLK1 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 ARHGEF6 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 PAK1 GNG4 GNG7 CDC42 GNGT1 GNG8 GNGT2 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism GLS2 GLUL RIMKLA RIMKLB GOT2 KYAT1 PYCR1 OAT PYCR2 PYCR3 GLS GLUD1 GLUD2 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines SLC25A32 DHFR2 ALDH1L1 ALDH1L2 SHMT2 SHMT1 MTHFD2L FOLR2 SLC46A1 SLC19A1 MTHFD1L MTHFR MTHFS MTHFD1 DHFR MTHFD2 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism ADA APRT HPRT1 PNP DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 LUM OMD PRELP ACAN FMOD CHST6 OGN KERA MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system B2M UBB MRC1 TLR2 UBA52 UBC RPS27A TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC26A2 SLC26A1 SLC26A11 PAPSS2 PAPSS1 SLC35B3 SLC35B2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP1A1 CYP2C9 CYP2C19 CYP2C8 EPHX2 CYP1A2 CYP1B1 CYP2J2 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins MRTFA RHOB DYNC1LI1 DYNC1LI2 DAAM1 CDCA8 SKA1 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B CDC42 DYNC1I1 CENPE NUF2 NUDC NUP160 NUP85 DYNLL2 BIRC5 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L ZWILCH CENPA ACTG1 CENPC KNTC1 CENPT CENPU SGO1 SEC13 SGO2 NUP133 DYNLL1 CKAP5 CENPF CENPH RANGAP1 PMF1 MAPRE1 CENPI TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CENPP CENPQ CENPS NUP43 DIAPH1 CLASP1 RANBP2 DIAPH3 DYNC1H1 NDE1 PLK1 CLIP1 MAD1L1 DVL1 DVL2 NUP37 DVL3 SRGAP2 ITGB3BP NDC80 RPS27 BUB1 CLASP2 FMNL3 FMNL1 XPO1 SPDL1 FMNL2 EVL SRF NSL1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E RAC1 RHOA KNL1 ZW10 PFN1 ITGB1 PFN2 DSN1 SCAI BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 KIF18A NDEL1 RHOC ACTB RHOD RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes YWHAE CEP57 CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA CEP290 NINL YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 TUBA4A HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 TUBG2 MZT2B HAUS8 MZT2A PRKAR2B NME7 HAUS7 TUBGCP2 CEP70 MZT1 CEP72 TUBGCP5 CEP192 TUBGCP6 PCNT TUBGCP3 TUBGCP4 CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CDK11A CEP152 NDE1 CDK11B PLK1 TUBB4B TUBB4A NEDD1 ALMS1 CDK1 CEP41 CEP43 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) CUL4A ERCC3 POLE4 COPS3 COPS6 COPS5 ERCC4 ERCC2 POLE2 ERCC1 ERCC6 POLE3 ERCC5 COPS8 AQR CUL4B COPS4 COPS2 PRPF19 LIG1 POLD1 RFC5 RFC3 RFC4 RFC2 CDK7 MNAT1 GPS1 ELL ERCC8 ZNF830 RBX1 PCNA ISY1 UBA52 RPA1 RPA2 RPA3 POLR2A UBB POLR2B POLK POLR2C POLR2D POLE UBC RFC1 POLR2G POLR2I RPS27A USP7 LIG3 POLR2J GTF2H1 GTF2H2 GTF2H3 XAB2 DDB1 GTF2H4 POLR2E GTF2H5 POLR2F POLR2H XPA CCNH COPS7B COPS7A PPIE POLR2K POLD3 POLR2L POLD4 TCEA1 POLD2 XRCC1 UVSSA RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport GPC1 LRP2 LRP10 GPC3 LRP12 LRP8 GPC2 GPC5 RETSAT GPC4 GPC6 APOA2 RDH11 APOA1 APOA4 SDC1 AGRN LPL TTR BCO2 GPIHBP1 HSPG2 BCO1 PNLIP APOB APOC3 PLB1 APOC2 LRAT AKR1C1 AKR1B10 APOM AKR1C3 SDC4 APOE LRP1 SDC2 AKR1C4 SDC3 RBP4 RBP2 RBP1 LDLR CLPS DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations B3GALNT2 SLC35A1 POMGNT2 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 MGAT5B LARGE1 LARGE2 POMGNT1 POMT2 FKTN POMT1 POMK RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle VAV2 ARAP2 BCR ARAP3 PIK3R2 PIK3R1 ABL2 CAV1 SRGAP2 ABR AMIGO2 NOXA1 NCKAP1L NOXO1 MCAM PAK1 NOX3 CDC42 PGRMC2 SNAP23 FERMT2 BRK1 NOX1 ARHGAP1 PAK4 ARHGAP6 IL32 GIT2 EMD MPP7 DSG2 ESYT1 OCRL CDC42EP1 VAMP3 TIAM1 ARHGAP39 SLITRK3 NHS SLITRK5 ARHGAP5 SYDE1 LMAN1 ARHGAP42 ARHGAP21 WASF1 WASF2 ARHGDIB LBR YKT6 ERBIN CYBB RAB7A CYBA ARHGAP35 BAIAP2 DOCK10 MCF2 LEMD3 BAIAP2L1 OPHN1 RAPGEF1 TMPO VANGL1 TAOK3 DEPDC1B PAK2 ABI2 ARHGAP17 ARHGAP15 ITGB1 ABI1 EPHA2 GARRE1 RACGAP1 LAMTOR1 NCF1 ARHGAP26 NCF2 NCF4 CYFIP1 ARHGAP32 NCKAP1 SLC1A5 TRIO JAG1 TFRC DIAPH3 SWAP70 STBD1 VRK2 RAC3 GIT1 PREX1 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL PIP5K1B CSNK2A1 DVL1 DVL2 DVL3 CSNK2A2 CSNK1E CSNK2B DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis TP53 PRDX2 CDKN2A GOLGA2 CDC25A PRDX1 APP CDC25B YWHAE LMNB1 CDK5 FASLG CAPNS1 CAPNS2 CDC25C C1QBP CAPN2 CAPN1 CAST FOXO3 SOD2 CDK5R1 JUN BCL2L11 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway LTBR TNFSF11 MAP3K14 CD40LG TRAF2 TNFRSF12A LTA TNFSF13B LTB TNFRSF11A TNFSF14 BIRC2 BIRC3 TRAF3 TNFSF12 TNFRSF13C DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production SMPD2 TNF TNFRSF1A RACK1 NSMAF SMPD3 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway TIFA UBB UBA52 UBC TAB3 MAP3K7 TAB2 TAB1 RPS27A TRAF6 ALPK1 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization RNF19B JAK2 HEYL MYC SOX10 MYCN TNRC6C JUP MOV10 CDH5 AGO3 AGO4 AGO1 AGO2 CDC42 FERMT2 CDH11 TNRC6A TNRC6B CLDN5 STRAP TFAP2A PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 POMT2 RELA POMT1 FLNA FARP2 VCL NFKB1 IL6 TRAF7 PATJ UBA52 ZNF217 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 MOGS PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 VASP PSMB2 PSMB3 PSMD2 PSMD3 RPN1 PSMB1 PSMD1 ADRM1 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 ZMYM2 JAK1 COL17A1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 TYK2 SRC PCSK6 PARD6B PARD6A TIAM1 CANX LAMC2 CTSS ITGB4 CTSL CTSB MAPK1 ACTN1 MAPK3 CRB3 ITGA6 PLEC CD151 LAMA3 FURIN PCSK7 CSNK2A3 ANK3 TMEM258 LAMB3 KMT5A RB1 F11R PARD3 H2AC19 H2AC14 VAV2 H2BC12L OST4 ARHGEF4 OSTC STT3A PVR PALS1 ARHGEF6 MDM2 PIP5K1C PRKCSH TCF3 SNAI1 DDOST SNAI2 CTNNA1 TGIF2 DAD1 H4C9 SMARCA4 GANAB H2AC20 NECTIN2 FOXQ1 DNTTIP1 EZH2 ZBTB33 H2AX FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 H3-3B H3C8 TCF12 SIRT1 ILK PARVA TESK1 CLDN2 ZC3H12A CLDN6 CLDN4 H2AJ CLDN3 CLDN9 ANG CLDN8 CLDN7 RSU1 CADM3 CADM1 CADM2 PARVB ANGPTL4 CLDN22 CLDN20 CLDN23 H3C15 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 SUZ12 CLDN19 H2BC9 CLDN18 H2BC8 CLDN17 H2BC5 CLDN16 ARHGAP32 H2BC3 FLNC ADAM33 H2BC1 LIMS2 LIMS1 CDH9 IL6ST CDH8 CDH7 CDH6 CDH3 IL6R ADAM19 FBLIM1 MPHOSPH8 CDH24 SDK1 SDK2 H2AB1 CDH10 CDH12 CDH13 CDH17 CDH18 CDH19 PARD6G NECTIN4 H2AC8 NECTIN3 NECTIN1 H2AC6 H2AC7 CTBP2 CTBP1 SP1 PRKCI CDH4 SEC11A CDH2 SEC11C DNM2 CSNK2A1 FOXA2 CSNK2A2 CDH15 CSNK2B H2BC26 KLF4 H2BC21 DST KDM1A RAC1 TWIST2 EED TWIST1 ARID1A SPCS3 H2BC17 SPCS2 XIAP SPCS1 H2BC12 H2BC13 H2BC14 H2BC15 ELMO1 ITGB1 DOCK1 HACE1 H2BC11 BIRC2 PXN TLE1 HDAC2 HDAC1 RBBP4 CLDN1 RBBP7 WT1 H2AZ2 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A1 SLC26A4 SLC26A11 SLC26A3 SLC26A7 SLC26A9 SLC26A6 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission GRIN1 CALM1 LRRC7 PPM1E PPM1F GRIN2A GRIN2C GRIN2D DLG2 CAMK1 DLG3 GRIN2B DLG4 CAMK2B CAMK2D DLG1 CAMK2A CAMK4 CAMK2G NEFL ACTN2 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA ABAT ALDH5A1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling STAT3 FCER2 CXCL8 CXCL1 CCR5 IL6 CXCL2 TIMP1 FPR1 PTGS2 IL12B IL12A PTAFR TNFRSF1B IL10 CCL3L3 IL10RB CSF3 ICAM1 TNFRSF1A CCL5 IL10RA CCL4 CCL2 CCR2 CCL19 CD86 JAK1 CD80 TNF CCR1 CCL22 CCL20 IL1RN CXCL10 CSF2 TYK2 IL1R2 IL18 IL1A IL1B LIF CCL3 CSF1 IL1R1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer EP300 PSEN2 APH1A HDAC4 APH1B HEYL MYC TBL1XR1 HDAC8 ADAM10 CREBBP PSENEN ADAM17 HDAC11 MAML2 PSEN1 CDK8 MAML1 HDAC5 NCSTN HDAC9 HDAC6 DLL4 MAML3 HDAC7 NEURL1 MIB1 SKP1 HDAC10 HEY1 JAG2 HEY2 SNW1 MAMLD1 NEURL1B RBX1 NCOR2 KAT2B KAT2A UBA52 MIB2 NCOR1 CUL1 HDAC2 TBL1X HDAC3 UBB NOTCH1 HDAC1 UBC RBPJ DLL1 RPS27A HES5 JAG1 HES1 CCNC NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism ADPRM GDA SAMHD1 DPYD AGXT2 NT5C2 NUDT5 UPP2 NT5C1A NT5C1B ITPA UPP1 DPYS ENTPD1 DNPH1 ENTPD2 ENTPD3 NUDT16 ENTPD4 NUDT15 ENTPD5 ENTPD6 ENTPD7 TYMP ENTPD8 NT5C NT5E XDH UPB1 PNP NT5M PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways MAPK8 PLCG2 NCKAP1L CDC42 NOX1 ARPC1B ARPC1A PLCG1 GNAI1 GNAI2 PRKX PRKACA RELA NFKB1 IL6 ABI2 IL10 ABI1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 PRKAR2B V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 ITPR1 V1-11 ITPR2 IGKV2D-30 V1-16 V1-13 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 DVL1 IGKV3-11 LYN DVL2 V2-8 V1-20 DVL3 IGKV2D-40 IGHV3-11 IGHV3-13 CD163 IGKV1D-16 PLK2 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 RHBDF2 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 NOXA1 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 BRK1 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 ADAM17 NCK1 IGLV3-19 ACTR3 IGKV2-30 ACTR2 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 V4-6 MYH2 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAPK14 WASF1 WASF2 WASF3 PRKACG CTSG BAIAP2 PRKACB MAPK1 ADCY9 PRKAR1B HMOX1 MAPK3 PRKAR1A BTK ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A FURIN PTK2 GNAS GSDMD YES1 VAV3 IGHG3 IGHG4 CYSLTR1 IGHG1 ACTB CYSLTR2 VAV1 IGHG2 GNAT3 VAV2 GNAZ CD3G NLRP3 FCGR3A SYK FGR HCK ADORA2B GNAI3 FYN C3 FCGR1A FCGR2A HSP90AB1 WAS NOXO1 AHCYL1 MYO9B ENTPD1 C3AR1 ENTPD5 IL18 IL1A IL1B P2RX4 ACTG1 CALM1 CYBA WASL NCKIPSD GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 WNT5A GNGT2 GGT1 FZD7 DPEP2 MEFV DPEP1 NFKB2 P2RX7 PYCARD PSTPIP1 CASP1 TXNIP GNG3 TXN SUGT1 GNG2 GNG5 GNG4 GNG7 GNG8 GGT5 ABL1 NT5E JUN RAC1 ELMO1 ELMO2 DOCK1 CRK CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) AKT1 NRF1 SIRT3 ATF5 DNAJA1 ESR1 LONP1 DEFA5 HSPA1B HSF1 FOXO3 SOD2 HTRA2 HSPD1 HSPE1 HSPA9 HSPA1A CAT TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK RFC5 RFC3 UBB RFC4 POLK RFC2 UBC RFC1 RPS27A PCNA UBA52 RPA1 RPA2 REV1 MAD2L2 RPA3 REV3L CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis ACAT2 LBR DHCR24 MVD SC5D PMVK MSMO1 MVK GGPS1 HMGCS1 DHCR7 PLPP6 LSS TM7SF2 EBP FDFT1 ARV1 SQLE FDPS IDI1 SREBF1 IDI2 SREBF2 CYP51A1 HSD17B7 NSDHL CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PEX3 SLC25A17 ABCD3 PEX2 ABCD1 ATAD1 PEX16 FIS1 PEX19 PEX11B GDAP1 PEX26 PXMP4 PEX12 PEX13 PEX14 ABCD2 ACBD5 PXMP2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions NRCAM SDCBP DCX CNTNAP1 CNTN1 ANK1 NFASC CELL DIVISION%REACTOME%R-HSA-68884.6 cell division PDS5B PDS5A MAU2 WAPL KIF23 SMC3 RAD21 STAG1 STAG2 KIF20A SMC1A PLK1 NIPBL METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se TXNRD1 PAPSS2 PAPSS1 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) ATF1 IRS1 ELK1 RPS6KA3 PIK3R2 RPS6KA5 RPS6KA2 PIK3CB NRAS RPS6KA1 PIK3R1 MEF2A MEF2C MAPKAPK3 FRS2 SHC3 PIK3CA ID1 EGR1 F3 JUNB PLCG1 PPP2R1A SH3GL3 MEF2D TCF12 RALA KIDINS220 JUND FOSB SHC1 IRS2 ADCYAP1 ADCYAP1R1 EP300 STAT3 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 ADORA2A YWHAB REST MAPKAPK2 NTRK1 CDK5 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 SRF AP2S1 DNAL4 SH3GL2 MAPK12 CHD4 NTRK2 PPP2R5D CDK5R1 MAPK14 PPP2CA MAPK11 PPP2CB NAB1 NAB2 PPP2R1B LYL1 ARC MAPK7 MAP2K5 VGF TRIB1 TPH1 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 FOS MAP2K1 ID2 MAP2K2 ID3 RAP1A RHOA SGK1 CDK5R2 RAPGEF1 MAPK1 BRAF CRKL MAPK3 SHC2 RALGDS CRK RALB SOS1 MAPK13 RIT1 RIT2 HRAS ID4 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling H2AC14 ERLIN2 CD274 CUL3 H2BC12L CD3G DERL2 OST4 RNF5 OSTC OS9 HIF1A STT3A MYC RNF185 STT3B B3GNT3 MYCN IRF1 PTPN6 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 DDOST TNRC6A DAD1 TNRC6B CREBBP CCND1 H4C9 PRKAG2 H2AC20 PRKAA1 PTPN11 EZH2 H2AX NEK2 BTRC ASH2L DERL3 YWHAG DERL1 RELA SKP1 TEAD1 H3-3B TCF7L2 TEAD2 TEAD3 H3C8 TEAD4 NFKB1 ATF3 PDCD1LG2 JUND ERLEC1 H2AJ UBA52 CD4 PDCD1 FOSB CUL1 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 SUZ12 UBC LEF1 H2BC9 H2BC8 H2BC5 TRAC PSMA7 CD3E H2BC3 CD3D PSMB6 RPS27A BRD4 PSMD8 TRBV12-3 H2BC1 TRAV29DV5 PSMB7 TRBV7-9 TRBC1 PSMB4 PSMD6 HLA-DQA2 HLA-DQA1 PSMB5 PSMD7 HLA-DPA1 RPN2 PSMB2 TRAV19 PSMB3 PSMD2 HLA-DRB5 PSMD3 HLA-DRB4 RPN1 PSMB1 PSMD1 HLA-DPB1 TRAV8-4 H2AB1 HLA-DRA HLA-DRB3 ADRM1 EP300 PSMA5 HLA-DQB2 STAT3 SEM1 HLA-DRB1 PSMA6 PSMA3 HLA-DQB1 PSMC5 COPS5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 NFKB2 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 KMT2A KMT2C PRKAB1 MAGT1 JAK1 NFE2L2 LCK CSNK2A1 GSK3B CSNK2A2 SEL1L DPY30 TCF7L1 PRKAG1 SPOP CSNK2B JUN H2BC26 CSK PRKAG3 H2BC21 WDR5 PRKAA2 FOS EED STAT1 RBX1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 MIB2 TUSC3 H2BC11 EPAS1 TCF7 CDK4 TMEM258 RBBP4 RBBP5 PRKAB2 WWTR1 RBBP7 VCP H2AC19 YAP1 H2AZ2 ERLIN1 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body LRP2 ABCD4 LMBRD1 TCN2 TCN1 LDLRAP1 CD320 ABCC1 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation XRCC5 HMGA1 BANF1 PSIP1 LIG4 XRCC6 XRCC4 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a MGAT2 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade APP SDC1 SERPINE2 PROS1 SERPINA10 SERPINA5 THBD PF4V1 CD177 GP1BB HSPG2 F2R F2 F3 F5 SERPINE1 F7 PROCR F8 F9 SERPING1 SERPINC1 PROZ ANO6 KNG1 F10 SERPIND1 F12 F11 GP5 ANO5 PRTN3 GP9 PROC SMPD1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN GP1BA ADAMTS13 VWF PF4 SDC4 KLKB1 SDC2 SDC3 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules GRIN1 PTPRS FLOT2 RTN3 GRIN2A GRIN2C GRIN2D PTPRD DLG3 GRIA1 GRIN2B DLG4 GRIA3 GRIA4 DLG1 PTPRF LRFN3 LRFN2 FLOT1 LRFN4 LRFN1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes EIF4A3 PIM1 KPNA7 KPNA4 KPNA5 KPNA3 PPM1B ILF2 PLCG1 IFIT5 ILF3 PPP2R1A EIF2AK2 SKP1 EIF2S3 OASL OAS1 OAS3 EIF2S2 EIF2S1 FLNA GBP3 GBP5 UBE2E1 HSPA2 RPS15 RPS14 RNASEL RPS17 UBA52 FLNB RPS16 RPS19 RPS18 RPS11 CUL1 PTPN2 RPS10 CENPS RPS13 UBB RPS12 UBC DNAJC3 RPS27A RPS4Y2 HSPA1B IFIT1 RPS4Y1 CDK1 IFIT3 IFIT2 SFN EIF4G3 STAT3 EIF4G2 EIF4E3 MX2 MX1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 NCK1 JAK1 NUP214 ADAR EIF1AX EIF3M EIF3K EIF4E2 EIF3L EIF3I EIF3J EIF3G PDE12 EIF3H EIF3E EIF3F EIF3C EIF3D HSPA8 EIF3A KPNB1 EIF3B RPS27L HSPA1A RPS15A EIF4G1 RPS3 ABCE1 RPS2 STAT1 MAPK3 FAU NPM1 KPNA2 RPS9 RPS7 RPS8 RPS5 RPS6 FURIN RPSA TARBP2 PRKRA MAP2K6 ACTB FANCC MAVS UBE2N NUP107 NUP188 PIN1 RPS4X KPNA1 NUP210 RPS3A IRF3 NUP93 NUP205 HSPA1L POM121 USP18 BECN1 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 ACTG1 EIF4A2 EIF4A1 NUP62 SNCA NDC1 SEC13 FNTA FNTB NUP133 NUP50 EIF4E NUP54 DHX9 NUP42 NUP43 RAE1 RANBP2 NUP35 SPHK1 NUP37 UBE2I CASP1 SUMO1 CHUK UBA7 UBE2L6 ISG15 HERC5 IKBKB TP53 TRIM25 ARIH1 IKBKG RIGI PPP2R5A PPP2CA PPP2CB PPP2R1B DUS2 OAS2 FAAP24 FAAP20 GBP2 GBP1 FAAP100 GBP4 CENPX FANCM FANCL FANCA FANCB FANCE PGGT1B FANCG NEDD4 FANCF OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 HIF1A PSMA2 PSMC4 PSMC1 PSMC2 HIF3A CUL2 VHL LIMD1 UBE2D1 ELOB ELOC RBX1 EGLN1 EGLN3 EGLN2 UBA52 WTIP UBE2D2 AJUBA EPAS1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A UBE2D3 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC MMACHC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation ERCC3 ERCC2 CCNK CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 SUPT4H1 CDK7 CTR9 SKIC8 RTF1 MNAT1 PAF1 ELOA2 SUPT5H CDK9 ELL ELOA NELFB ELOB NELFCD NELFA ELOC NELFE NCBP1 NCBP2 CTDP1 EAF1 CDC73 EAF2 POLR2A POLR2B POLR2C POLR2D LEO1 POLR2G POLR2I POLR2J GTF2H1 SUPT6H GTF2H2 GTF2H3 GTF2H4 POLR2E GTF2H5 AFF4 POLR2F POLR2H CCNH SSRP1 POLR2K POLR2L MLLT1 MLLT3 TCEA1 IWS1 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN TNKS TNKS2 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation CALM1 PRKAR2A PRKAR2B PRKACG PRKACB NBEA ADCY9 PRKAR1B PRKAR1A ADCY4 PRKACA ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events RPS6KA3 LRRC7 RPS6KA2 NRAS RPS6KA1 GRIA1 GRIA2 DLG1 PDPK1 PRKAB1 RASGRF2 GRIN1 GRIN2A PRKAG2 CAMK1 CAMKK1 CAMKK2 PRKAA1 GRIN2B SRC PRKX PRKACA PRKAG1 PRKAG3 CALM1 PRKACG PRKAA2 RAC1 PRKACB NRG1 MAPK1 PRKAR1B MAPK3 PRKAR1A KPNA2 CAMK4 ADCY1 ADCY8 RPS6KA6 ACTN2 PRKAR2A PRKAR2B GRIN2C GRIN2D DLG2 DLG3 DLG4 RASGRF1 CAMK2B PRKAB2 CAMK2D GIT1 CAMK2A NRGN HRAS CAMK2G NEFL G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint H2BC12L PIAS4 RNF168 UBE2N MDC1 KAT5 CHEK2 CHEK1 RAD9B YWHAQ RAD9A YWHAH HUS1 UBE2V2 YWHAB EXO1 DNA2 RHNO1 H4C9 TOPBP1 TP53 WEE1 RFC5 RFC3 RFC4 RFC2 YWHAZ ATRIP YWHAE BARD1 RAD17 RBBP8 ATM H2AX ATR YWHAG RAD50 BRCA1 H2BC26 H2BC21 HERC2 RMI2 RMI1 TOP3A BRCC3 BABAM1 BABAM2 UIMC1 H2BC17 ABRAXAS1 RNF8 WRN H2BC12 H2BC13 H2BC14 H2BC15 RPA1 H2BC11 RPA2 RPA3 RAD1 CCNB1 NSD2 CCNA2 MRE11 CCNA1 H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 H2BC1 CDC25C BRIP1 BLM CDK1 SFN TP53BP1 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway MRI1 ENOPH1 APIP GOT1 ADI1 MTAP THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis CD8B ATP6V1H HCK RAC1 FYN AP1M2 AP1M1 PAK2 ELMO1 DOCK2 PACS1 CD28 CD4 B2M ARF1 LCK AP2A1 HLA-A AP2B1 AP2A2 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 AP1B1 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks H2BC12L PIAS4 RNF168 UBE2I UBE2N MDC1 MAPK8 KAT5 CHEK2 UBXN1 SUMO1 UBE2V2 ABL1 KDM4A KDM4B H4C9 TP53 SMARCA5 BARD1 ATM H2AX BAP1 RAD50 PHF6 BRCA1 H2BC26 H2BC21 HERC2 BRCC3 PPP5C BABAM1 BABAM2 UIMC1 BAZ1B H2BC17 ABRAXAS1 RNF8 H2BC12 APBB1 H2BC13 EYA2 H2BC14 EYA3 H2BC15 EYA4 UBA52 H2BC11 UBB NSD2 MRE11 UBC H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 RPS27A H2BC1 EYA1 TP53BP1 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) OPN1MW RLBP1 OPN1LW AWAT2 RBP3 DHRS3 OPN1SW FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm OSR1 PAX2 BMP4 FOXC2 FOXC1 PAX8 LHX1 FGF2 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy TOMM20 TOMM22 MAP1LC3A FUNDC1 ATG9A ATG12 VDAC3 UBE2N VDAC2 TOMM40 ATG5 PINK1 MTERF3 TOMM7 VDAC1 TOMM5 TOMM6 UBA52 UBE2D2 TBK1 OPTN MFN1 MFN2 SQSTM1 MAP1LC3B TOMM70 UBB UBC ULK1 PRKN RPS27A UBE2D3 UBE2V1 CSNK2A1 CSNK2A2 CSNK2B UBE2L3 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling CXCL6 RPS6KA3 CXCL9 GLP1R CXCL8 RPS6KA2 CXCL1 CXCL13 RPS6KA1 CXCL3 CXCL2 CX3CL1 CXCL5 CXCL16 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CXCR5 CXCR6 CXCR1 CDC42 CCL5 CCR6 CXCR3 CCL4 CXCR2 CCL1 CCR2 CCL19 CCL16 CCR10 CCL25 CCR1 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR3 CCL28 CCL27 LHCGR TRPC7 TSHR FSHR GPHA2 GPHB5 TRPC6 TRPC3 OPN1LW PDYN PRKCQ RASGRP2 RASGRP1 DRD1 DRD3 DRD4 DRD5 CX3CR1 AVPR1B ADORA2A AVPR1A ADORA3 ADORA1 AVP AKT1 PRKCD PRKCA PRKCE PDE3B TIAM1 GNAT1 ITGA5 PRKACG PRKACB SST MAPK1 ADCY9 PRKAR1B MAPK3 PRKAR1A ADCY4 ADCY3 ADCY2 SOS1 ADCY1 PIK3CG ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNAS HRAS PDE1B PDE1A PDE2A PDE11A PDE10A NRAS C3 OPN1MW AHCYL1 CAMKK1 CAMKK2 C3AR1 PIK3R3 PIK3R6 PIK3R5 CCR5 CXCR4 TAS2R20 PF4 GNAL NBEA GCGR TAS2R10 TAS2R13 PPP1CA TAS2R14 TAS2R16 TAS2R40 TAS2R41 TAS2R43 GABBR2 TAS2R46 GABBR1 TAS2R30 TAS2R31 TAS2R38 TAS2R39 IAPP CRH ROCK1 MCHR1 PPP2R5D PPP2CA PPP2CB TAS2R50 PPP2R1B PLEKHG5 ITGB1 NPY CAMK4 SSTR3 RHO TRIO PLA2G4A ITSN1 OPRM1 CAMK2B RAMP2 CAMK2D CAMK2A PREX1 MGLL CAMK2G PRKCB OPRK1 PIK3R2 MC4R EDNRB PIK3R1 NGEF EDN1 EDN3 ADM MC3R ABR PIK3CA MC1R MC5R NPFFR2 NPFFR1 CALCRL NPFF QRFPR HCRT QRFP HCRTR2 HCRTR1 F2R F2 TAS2R7 EGFR TAS2R8 KNG1 GNAI1 GNAI2 PPP2R1A HCAR2 HCAR3 HCAR1 PRKX PLCB3 PRKACA PLCB4 GRM4 FGD1 TAS2R1 FGD2 GCG TAS2R3 PLCB1 TAS2R5 PLCB2 FGD3 TAS2R4 FGD4 MCF2 CXCL12 AGT CHRM3 AKT2 AKT3 TAS1R2 OXTR TAS1R1 RGSL1 TAS1R3 GRPR EDNRA PROK2 PROK1 PRKAR2B UTS2R PRKCH TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 ITPR1 LPAR4 ITPR2 NTSR1 NTSR2 GPR17 ITPR3 NMB XCR1 NMBR ADCYAP1 LPAR5 OBSCN ADCYAP1R1 LPAR6 NMS NMU GNRH2 GNRH1 PSAP MLN BRS3 GPRC6A GPR132 ADRA2B CCKAR GNRHR FFAR4 FFAR3 GAST FFAR2 GPR39 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PLXNB1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 ADRA2C GPR143 RASGRF2 ADRA2A MT-RNR2 F2RL1 F2RL2 F2RL3 DGKG DGKE DGKD CHRM1 DGKB GPR68 DGKA GPR65 PLEKHG2 PMCH CHRM5 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR SOS2 CASR DGKZ LTB4R2 SRC DGKQ ROCK2 UTS2 DGKK DGKI DGKH ABHD6 NTS MCHR2 HRH1 GRK5 PDE1C TAC3 GRK2 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2C OXT HTR2A TRH GRM1 LTB4R GRM5 BDKRB2 BDKRB1 GNRHR2 XCL2 XCL1 DAGLB RGS18 MMP3 RGS17 CGA RGS19 BTK RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 KPNA2 CCK KISS1 CHRM2 CHRM4 KALRN ADRB1 GIP ADRB2 HTR4 HTR6 TAAR3P HTR7 HRH2 HRH4 HTR1E NET1 TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1B AKAP13 TAAR5 TAAR2 HTR5A TAAR1 ADRB3 VAV3 CYSLTR1 RHOC SCT CYSLTR2 RXFP4 VAV1 GNAT3 FFAR1 VAV2 RHOB GNAZ RXFP1 ARHGEF9 RXFP2 RXFP3 ARHGEF3 GPR176 ARHGEF4 ADORA2B AGTR2 ARHGEF1 GNAI3 FPR1 FPR3 GHRHR ARHGEF2 GALR3 ARHGEF7 OPN1SW GALR2 GALR1 ARHGEF5 NPBWR1 NPBWR2 ARHGEF6 GPR15 GPR183 PNOC GPR18 PAK1 GPR27 C5AR1 PDPK1 GPR25 GPR20 C5 PTH1R GPR37 GPR32 GPR31 PTH2R RGR GPR45 SAA1 GPR150 P2RY12 P2RY13 P2RY14 GPR55 SCTR ADRA1D ARRB1 ADRA1B ADM2 ADRA1A MTNR1A TBXA2R MTNR1B GNA12 GPR83 ARHGEF33 GPR84 ARHGEF35 RLN2 ARHGEF37 RLN3 ARHGEF38 INSL3 CALCA INSL5 PTH2 CALM1 P2RY4 APLN VIPR1 ARHGEF40 VIPR2 RRH OXER1 PTGDR GPR37L1 TAS2R19 TAS2R42 GIPR TAS2R45 ARHGEF26 CRHR1 ARHGEF25 PENK PPY PPP1R1B PDE3A TAS2R60 PTGDR2 RGS9 PPP3CC RGS6 OXGR1 RGS7 GPBAR1 GAL PTGER4 OPRD1 NPB TSHB RAMP3 PTH ECT2 FSHB PTGER2 PTGER3 NPW ARHGEF39 GNG10 GHRH CRHR2 MC2R RAMP1 CCL4L2 NPY2R RGS8 GNG12 PDE8B GNG11 PDE8A GNG13 NPY1R PCP2 APLNR GNB2 CALCB GNAQ SUCNR1 GNB1 GRK3 CALCR GNB4 GRK6 GNB3 ARHGEF10L GNB5 OPN3 MCF2L GNAT2 PRKCG OPN5 ARHGEF11 GNGT1 PYY ARHGEF10 GPSM1 ARHGEF12 GPSM2 ARHGEF15 GNGT2 TAS2R9 ARHGEF17 PPP3R1 ARHGEF16 GRM3 ARHGEF19 HEBP1 POMC ARHGEF18 GRM2 GRM7 TIAM2 GRM6 APP GPER1 GRM8 PDE4A ARRB2 GPSM3 PPP3CA PTGIR PPP3CB NPY5R PDE4D GLP2R PDE4C GNA14 SSTR1 LHB GNA13 GNG3 SSTR2 GNA15 SSTR4 SSTR5 GNG2 CORT GNG5 RGS14 GNG4 NPY4R GNG7 OPRL1 GNA11 PTHLH GNG8 CNR2 CNR1 RGS20 S1PR3 RGS22 S1PR2 S1PR5 RGS11 S1PR4 RGS10 RGS12 PDE7B VIP AVPR2 PDE7A CDK5 MAPK7 RHOA HBEGF LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis B4GALT1 LALBA SLC2A1 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway FUT3 CHST10 LHB CGA FUT8 MAN2A2 MGAT2 CHST8 MAN2A1 FUCA1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation UGT2B7 UGT1A1 UGT2B28 SLC35D1 SLC35D2 UGT1A5 UGP2 UGT1A3 UGT1A9 ABHD10 UGT1A8 UGT1A4 UGT1A7 UGT1A6 UGDH UXS1 UGT1A10 UGT2A3 UGT2A2 UGT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B4 UGT3A2 UGT3A1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation RHEB TNRC6C MOV10 AGO3 AGO4 EGR1 AGO1 AGO2 SNAI1 SNAI2 TNRC6A TNRC6B MLST8 ATN1 TRIM27 SALL4 USP13 MAF1 TNKS TNKS2 RNF146 FRK OTUD3 EZH2 MKRN1 MTOR PML WWP2 UBA52 AKT2 AKT3 PSMD12 PSMD11 UBB PSMD14 MBD3 PSMD13 SUZ12 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 GATAD2B PSMB2 GATAD2A PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ATF2 RRAGA RRAGC PPARG RRAGB RRAGD AKT1 TP53 REST BMI1 PTEN RING1 HDAC5 RNF2 CSNK2A1 HDAC7 CSNK2A2 CBX8 CHD4 PHC2 CHD3 CBX6 PHC1 CSNK2B JUN CBX4 CBX2 RPTOR PHC3 KDM1A EED MAPK1 XIAP MAPK3 STUB1 HDAC2 LAMTOR2 LAMTOR1 HDAC3 LAMTOR4 MECOM LAMTOR3 LAMTOR5 HDAC1 MTA1 RBBP4 USP7 NR2E1 RCOR1 NEDD4 PREX2 RBBP7 MTA2 SLC38A9 MTA3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation VEGFA TGFB2 TGFB3 CFD CD109 CLU AHSG PROS1 ITGB3 ALDOA F13A1 PDGFB FGB LAMP2 FGA TGFB1 FGG F5 SERPINE1 F8 PECAM1 EGF SERPING1 PPBP KNG1 STXBP2 ORM1 ORM2 CAP1 FN1 CD36 CALM1 FLNA VCL CFL1 APOOL APOA1 TUBA4A ISLR HABP4 CHID1 GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 ENDOD1 SPARC APOH SOD1 VTI1B MANF CALU MAGED2 FERMT3 ACTN2 ECM1 OLA1 ABCC4 CTSW SERPINA4 TMSB4X TIMP3 ANXA5 TOR4A SPP2 IGF2 LEFTY2 PF4 IGF1 LY6G6F VEGFB VEGFC QSOX1 VEGFD ITGA2B LHFPL2 PCYOX1L POTEKP MMRN1 CD63 FAM3C APLP2 SERPINF2 TMX3 SELENOP SCG3 RARRES2 CYRIB SCCPDH HRG LGALS3BP WDR1 PLEK PHACTR2 SRGN PSAP ITIH4 ITIH3 CLEC3B CDC37L1 CYB5R1 CD9 APP ALB A1BG SERPINA3 ACTN4 GAS6 HSPA5 SELP PPIA HGF TF A2M TLN1 PCDH7 RAB27B TIMP1 TTN ACTN1 PFN1 PLG VWF SERPINA1 THBS1 BRPF3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production MYD88 DHX9 NFKB1 DHX36 RELA NFKB2 IRF7 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus XRCC5 HMGA1 BANF1 KPNA1 PSIP1 LIG4 XRCC6 XRCC4 PPIA NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling NTF3 NTRK3 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK PIK3CA IRS1 PIK3R2 PIK3CB PIK3R1 GRB2 SOS1 LTK TNK2 ALKAL2 ALKAL1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM SLC34A2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy CETN1 UBB UBC PCNT EEF1A1 RPS27A IFT88 HDAC6 HSP90AB1 PLIN3 UBA52 CFTR PARK7 ARL13B HSPA8 HBB RNASE1 GFAP LAMP2 PLIN2 HSP90AA1 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels KCNN2 KCNMB1 KCNMA1 KCNMB2 KCNMB3 KCNMB4 KCNN1 KCNN3 KCNN4 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes EP300 ABCF2 ABCG2 MAFK NFE2L2 ABCC3 CREBBP ABCC1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K SRC PIK3CA IRS1 NTF3 PIK3R1 NTRK3 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling CXCL8 VEGFA PIK3R1 JAK2 IL2RG HIF1A BCL6 RHOU PIM1 MYC JAK3 NANOG CCL11 F13A1 IL13RA2 CCL2 IL13RA1 TGFB1 CCND1 HSP90B1 JUNB CCL22 SAA1 ALOX5 BIRC5 IL18 IL1A IL1B LIF COL1A2 ZEB1 FN1 CD36 HSP90AA1 NOS2 IL6 FASLG IL12B IL12A TNFRSF1B IL10 MUC1 FSCN1 OPRD1 LCN2 RORC IL6R SOCS1 STAT3 BCL2 POMC FCER2 BCL2L1 ITGAX ANXA1 RORA PTGS2 IL23R IL23A ITGAM FOXO3 FOXO1 AKT1 HGF JAK1 IGHE VIM TP53 TNF MCL1 IL4R NDN IL13 TYK2 IRF4 CEBPD S1PR1 SOCS5 STAT6 CDKN1A HSPA8 POU2F1 SOX2 BATF IL4 TIMP1 FOS TWIST1 STAT1 MMP1 HMOX1 MMP2 MMP3 IL17F MMP9 ICAM1 ITGB1 MAOA IL17A GATA3 FGF2 SOCS3 LAMA5 ALOX15 LBP VCAM1 OPRM1 ITGB2 OSM IGHG4 IGHG1 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides SLC15A4 CTNS SLC15A1 SLC15A3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions FLNA FLNC ILK LIMS2 ACTN1 PARVA LIMS1 ARHGEF6 TESK1 VASP ITGB1 FBLIM1 FERMT2 RSU1 PXN PARVB ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases ATP8A2 ATP8A1 ATP12A SLN ATP11C ATP11B ATP1B3 ATP11A ATP1B2 ATP1B1 ATP7A ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP2B4 ATP2A3 ATP4B ATP2A2 ATP4A ATP2B3 FXYD4 ATP2A1 ATP2B2 FXYD3 ATP2B1 SRI FXYD2 CALM1 FXYD1 FXYD7 FXYD6 CUTC PDZD11 ATP7B ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 PLN ATP9B ATP9A ATP13A1 ATP13A4 CAMK2B ATP13A5 ATP13A2 CAMK2D CAMK2A CAMK2G REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation EP300 TXNIP KAT2B TXN SIRT3 FOXO4 FOXO3 FOXO1 CREBBP SIRT1 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors AKT1 YWHAQ FOXO6 FOXO4 YWHAZ FOXO3 FOXO1 YWHAG YWHAB AKT2 AKT3 SFN REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA ZBP1 DTX4 UBB UBC TRIM21 TRIM56 RPS27A STING1 UBA52 TBK1 TREX1 IRF3 TRIM32 NLRP4 DDX41 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNA14 GNB1 GNA13 GNG3 GNA15 GNB4 GNB3 GNG2 TBXA2R AAMP GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 GNGT2 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 DOK1 AKT1 UBB PTK6 UBA52 UBC ARAP1 RPS27A CBL NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR FLT1 NRP1 NRP2 KDR DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification FASTKD2 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN TRMT61B SLIRP MTERF3 MTPAP LRPPRC ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia IVD SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH DLD DLST KGD4 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones H3C8 JMJD6 KDM1A KDM6A RIOX2 KDM5A KDM5B KDM5C PHF2 KDM5D UTY KDM6B PHF8 KDM7A KDM3A KDM3B KDM4A KDM4B KDM4C H4C9 KDM4D H3C15 KDM1B KDM2A KDM2B ARID5B TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 RBSN MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 TLR9 PELI1 LRRC14 TRAF6 USP14 IRF7 PELI3 PIK3C3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 PPP2R1A BTRC RELA SKP1 FBXW11 NFKB1 TICAM2 LY96 TRAF2 TICAM1 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT PIK3R4 DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 EEA1 TASL IRF5 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 PPP2R5D TLR7 MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 FOS MAP2K1 MAPK1 SLC15A4 MAPK3 MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors VIPR1 GLP1R VIPR2 GHRHR GIPR GLP2R GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GIP GNG10 GHRH VIP GNG12 GNAS GNG11 GNG13 GNB2 GNB1 GCGR SCTR GNB4 GNB3 GNB5 ADCYAP1 ADCYAP1R1 GCG GNGT1 GNGT2 SCT INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC7 UBE2C BUB1B UBE2E1 CDC20 UBE2S CDC16 BUB3 ANAPC4 MAD2L1 ANAPC5 ANAPC1 ANAPC2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis DFFB DFFA HMGB2 MAPK8 UNC5A UNC5B KPNA1 YWHAQ DCC HMGB1 YWHAH PPP1R13B CASP6 DNM1L ADD1 CLSPN MAGED1 DBNL GSN STK24 BCAP31 STK26 GAS2 MAPT APAF1 YWHAE DYNLL2 TJP2 NMT1 YWHAG BAX CDKN2A TICAM2 TRADD LMNB1 FNTA LY96 TNFRSF10B FASLG TNFRSF10A DYNLL1 TRAF2 TICAM1 CASP8 TNFSF10 PAK2 FAS RIPK1 CD14 FADD UBA52 PPP3CC TLR4 AKT2 AKT3 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BCL2L11 ADRM1 PPP3R1 SFN BAD PSMA5 STAT3 SEM1 BCL2 PMAIP1 PSMA6 BMF PSMA3 BID PSMC5 BBC3 ARHGAP10 PSMA4 BCL2L1 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 GSDME PSMC2 CTNNB1 CDH1 ACIN1 UACA BMX TP63 GZMB YWHAB AKT1 VIM TP53 PRKCD TP53BP2 CYCS APIP YWHAZ DSG2 TFDP1 SATB1 TFDP2 TP73 E2F1 KPNB1 ROCK1 APC DSP CASP3 OPA1 H1-1 H1-0 H1-3 PKP1 H1-2 H1-5 OCLN H1-4 MAPK1 TJP1 XIAP DSG3 MAPK3 DSG1 BIRC2 PLEC PTK2 DAPK1 OMA1 DAPK2 DAPK3 APPL1 C1QBP AVEN GSDMD DIABLO SPTAN1 CARD8 CASP9 CASP7 BAK1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis MOCS2 MOCOS MOCS3 GPHN FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes POMC SIRT3 INS NR3C1 G6PC1 FOXO6 PLXNA4 FOXO4 FOXO3 SOD2 FOXO1 NPY PPARGC1A ATXN3 CAT RETN SREBF1 HDAC2 SMAD2 AGRP SMAD4 SMAD3 HDAC1 ABCA6 FBXO32 PCK1 IGFBP1 TRIM63 GCK SIN3A NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development WNT9B HNF1B POU3F3 HNF4A DLL1 WNT4 IRX1 WT1 IRX2 LHX1 JAG1 LFNG ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria TP53 TP63 BBC3 TP73 TP53BP2 PPP1R13B E2F1 TFDP1 TFDP2 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas LAMA5 LAMC3 LAMA3 EGF LAMB3 LAMB1 LAMA2 LAMA4 LAMB2 FGF7 FGF4 LAMA1 VTN FGF10 LAMC2 LAMC1 FN1 FGF2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants EP300 PSEN2 APH1A HDAC4 APH1B HEYL MYC TBL1XR1 HDAC8 ADAM10 CREBBP PSENEN ADAM17 HDAC11 MAML2 PSEN1 CDK8 MAML1 HDAC5 NCSTN HDAC9 HDAC6 DLL4 MAML3 HDAC7 NEURL1 MIB1 SKP1 HDAC10 HEY1 JAG2 HEY2 SNW1 MAMLD1 NEURL1B RBX1 NCOR2 KAT2B KAT2A UBA52 MIB2 NCOR1 CUL1 HDAC2 TBL1X HDAC3 UBB NOTCH1 HDAC1 UBC RBPJ DLL1 RPS27A HES5 JAG1 HES1 CCNC ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SNAP25 CHAT VAMP2 TSPOAP1 UNC13B RAB3A SYT1 STX1A CPLX1 SLC5A7 RIMS1 PPFIA1 PPFIA4 PPFIA3 SLC18A3 PPFIA2 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid RXRG PDK1 ALDH1A2 RDH10 PDHX CYP26A1 CYP26B1 RDH16 DLAT RDH14 RDH13 PDK4 ALDH8A1 DLD RARB ADH4 RDH11 CYP26C1 PPARD RXRA ALDH1A1 PDHB RARA RDH5 CRABP2 ADH1C FABP5 ADH1A RXRB AKR1C3 PDHA2 PDHA1 CRABP1 DHRS3 PDK3 DHRS4 RARG ALDH1A3 SDR16C5 PDK2 DHRS9 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis FAR1 AWAT2 FAR2 GNPAT AGPS AWAT1 DHRS7B DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 RAD9B RAD9A RPA1 HUS1 RPA2 EXO1 DNA2 RPA3 RHNO1 TOPBP1 RAD1 RFC5 RFC3 RFC4 RFC2 MRE11 ATRIP NBN BARD1 BRCA2 RAD51AP1 BRIP1 RAD17 RBBP8 ATM ATR BLM XRCC2 PALB2 RAD50 BRCA1 RAD51 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling FGF4 FGF22 FGF3 FGF18 FGF10 SPRED2 SPRED1 FGF23 FGFRL1 FGF2 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 CRB3 PATJ TJP1 PALS1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling GAB1 EGF PIK3R1 ERBB2 EGFR NRG1 NRG2 EREG BTC NRG3 PIK3CA NRG4 HBEGF SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling SHC1 EGF PRKCD NRAS PRKCA ERBB2 EGFR NRG1 PTPN12 PRKCE NRG2 EREG BTC NRG3 NRG4 HBEGF SOS1 HRAS HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones H2AC14 KANSL1 SAP130 KANSL2 KANSL3 KAT8 CLOCK HCFC1 KAT14 CREBBP H4C9 TADA2A ZZZ3 H2AC20 PHF20 SGF29 TRRAP H2AC17 H2AC12 EPC1 KAT7 NCOA1 SUPT20H NCOA2 ATXN7L3 H3C8 ACTL6A TADA2B H2AC25 H2AC21 KAT2B KAT2A ING4 ING3 TAF9 SUPT3H TAF6L H3C15 BRD8 ELP1 H2BC9 ELP2 H2BC8 ELP3 H2BC5 ELP4 MCRS1 ELP5 H2BC3 ELP6 H2BC1 JADE1 YEATS4 JADE3 JADE2 RUVBL2 TAF12 RUVBL1 TAF10 H2AC1 SUPT7L MORF4L1 EP300 KAT6B MORF4L2 HAT1 ENY2 TAF5L ATXN7 H2AC8 EP400 H2AC6 DMAP1 H2AC7 MRGBP TADA1 ATF2 KAT5 VPS72 MSL2 MSL3 H2BC18 MSL1 MBIP MEAF6 USP22 DR1 YEATS2 TADA3 OGT H2BC26 PAX3 ING5 H2BC21 WDR5 BRD1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 KAT6A RBBP7 H2AC19 ACTB BRPF1 BRPF3 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion PSMA5 SEM1 SHH PSMA6 SYVN1 PSMA3 DERL2 PSMC5 PSMA4 PSMC6 IHH OS9 PSMC3 HHAT PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ERLEC1 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 SEL1L PSMB3 PSMD2 VCP DHH PSMD3 PSMB1 PSMD1 ADRM1 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands TNFRSF10C FAS TP53 TNFRSF10D TP63 TP73 TP53BP2 PPP1R13B TNFRSF10B TMEM219 TNFRSF10A IGFBP3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis STAT3 BCL2 PMAIP1 BMF BID BBC3 BCL2L1 GSDME MAPK8 UACA YWHAQ TP63 YWHAH GZMB PPP1R13B YWHAB AKT1 TP53 APAF1 APIP YWHAZ TP53BP2 CYCS YWHAE DYNLL2 TFDP1 TFDP2 TP73 E2F1 YWHAG NMT1 BAX CASP3 CDKN2A DYNLL1 MAPK1 CASP8 XIAP MAPK3 PPP3CC AKT2 AKT3 C1QBP AVEN GSDMD DIABLO CARD8 CASP9 CASP7 BAK1 BCL2L11 PPP3R1 SFN BAD JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IKBKG RIPK2 NOD1 NOD2 MAP2K4 UBE2N TAB3 TAB2 MAPK9 TAB1 MAPK8 UBE2V1 MAP2K7 MAPK10 MAP3K7 IRAK1 IRAK2 TRAF6 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells GLUL SLC1A2 SLC1A3 SLC38A1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration CBFB AKT1 ITGBL1 MMP13 AKT2 AKT3 ITGA5 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies ACSS3 HMGCS2 ACAT1 BDH2 HMGCLL1 BDH1 HMGCL AACS INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR EPGN EGF AREG EGFR HBEGF TGFA EREG BTC RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 TBP GTF2B GTF2A1 GTF2F1 GTF2A2 GTF2F2 TAF9 TAF1L POLR2A POLR2B POLR2C GTF2E1 POLR2D GTF2E2 CDK7 POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH TAF8 POLR2K POLR2L TAF4B TAF7 TAF6 TAF7L TAF5 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SREBF1 EP300 NCOA1 CPT1A NCOA2 TBL1X HDAC3 SMARCD3 NCOA6 MED1 CHD9 RORA TBL1XR1 RORC CARM1 HELZ2 RXRA NR1D1 NCOR1 NRIP1 PPARGC1A PPARA TGS1 CREBBP SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants CALM1 VCL NRAS PHB1 JAK2 ARRB2 MAP2K1 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 ITGB3 MAP3K11 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG BRAP RAP1B KRAS VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 CAMK2B CAMK2D PEBP1 CAMK2A CSK HRAS CAMK2G TLN1 FN1 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain F8 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism ABCD4 MTR CBLIF MMUT AMN MTRR MMACHC CUBN MMAA MMADHC MMAB LMBRD1 TCN2 CD320 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal MGMT ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) IRS2 LYN EPO JAK2 PLCG1 EPOR PLCG2 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP GDF2 SMAD9 INHBA SMAD5 BMPR1B BMPR1A ACVRL1 BMP2 BMP10 BMPR2 CHRDL1 AMH SKI NOG SMAD1 SMAD4 GREM2 SMURF2 TGFBR3 SMURF1 SMAD6 SMAD7 FSTL1 UBE2D3 ACVR2B ACVR2A INHA UBE2D1 AMHR2 CER1 ZFYVE16 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal DYNC1LI1 DYNC1LI2 NUP37 CDCA8 ITGB3BP NDC80 SKA1 RPS27 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B BUB1 CLASP2 XPO1 SPDL1 DYNC1I1 CENPE NUF2 NUDC NUP160 DYNLL2 NUP85 BIRC5 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L NSL1 ZWILCH CENPA PPP2R5B PPP2R5A PPP2R5D CENPC PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E KNTC1 CENPT CENPU SEC13 SGO1 SGO2 NUP133 DYNLL1 CKAP5 CENPF KNL1 ZW10 CENPH RANGAP1 MAPRE1 PMF1 CENPI TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO DSN1 CENPP CENPQ CENPS BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 NUP43 KIF18A CLASP1 RANBP2 DYNC1H1 NDE1 PLK1 CLIP1 NDEL1 MAD1L1 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism PPM1K ACAT1 BCKDK DLD DBT MCCC2 BCKDHA MCCC1 BCKDHB IVD AUH HIBCH ECHS1 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy CSNK2A1 MAP1LC3A FUNDC1 CSNK2A2 ULK1 ATG12 CSNK2B ATG5 MAP1LC3B SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants CALM1 VCL NRAS PHB1 JAK2 ARRB2 MAP2K1 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 ITGB3 MAP3K11 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG BRAP RAP1B KRAS VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 CAMK2B CAMK2D PEBP1 CAMK2A CSK HRAS CAMK2G TLN1 FN1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair H2AC14 H2BC12L POLE4 H2AC8 POLE2 H2AC6 H2AC7 POLE3 ACD TINF2 TERF1 TERF2 POT1 TERF2IP LIG1 POLD1 H4C9 RFC5 RFC3 RFC4 RFC2 H2AC20 H2AX NTHL1 H2BC26 NEIL3 FEN1 NEIL1 H2BC21 H2BC17 PCNA PARG H2BC12 PNKP POLB H2BC13 PARP1 H2BC14 MBD4 H2BC15 SMUG1 NEIL2 H2AJ APEX1 ADPRS RPA1 H2BC11 RPA2 RPA3 OGG1 POLE H2BC9 RFC1 H2BC8 PARP2 H2BC5 H3-4 H2BC3 MPG LIG3 H2BC1 TDG H2AC19 POLD3 H2AB1 POLD4 POLD2 H2AZ2 XRCC1 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction PAK2 ELMO1 HCK DOCK2 RAC1 FYN LCK IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones GOSR2 EDEM1 SYVN1 TSPYL2 DDX11 SSR1 GSK3A EXTL2 SULT1A3 HSPA5 CUL7 EXTL3 WFS1 TPP1 ATP6V0D1 ADD1 WIPI1 CTDSP2 DNAJB9 SEC31A SERP1 TATDN2 PPP2R5B PDIA6 PDIA5 KLHDC3 SRPRA TLN1 SRPRB HYOU1 GFPT1 ACADVL LMNA DCTN1 EXTL1 ARFGAP1 SHC1 CXXC1 PREB DNAJC3 KDELR3 PLA2G4B FKBP14 ZBTB17 MYDGF YIF1A HDGF ERN1 DNAJB11 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB8 ABCB6 ABCB7 ABCB10 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules ERLIN2 LRRC8D CP LRRC8A LRRC8B LRRC8E DMTN MMGT1 NIPA1 CTNS NIPA2 MYLIP SLC16A1 AZGP1 PIP AKAP1 ATP7A SLC12A3 SLC12A1 SLC11A1 SLC12A6 ABCA6 ABCD1 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 SLC5A8 TRPC5 VLDLR HBA2 MCOLN3 DERL3 TRPC6 DERL1 TRPC3 CETP TRPA1 EIF2S3 TRPC4 TRPC1 ABCG1 TRPV2 EIF2S2 TRPV3 EIF2S1 TRPV1 MCOLN1 MCOLN2 TRPC4AP ATP6V1H TRPV6 TRPV4 PDZD11 TRPV5 ABCB7 ABCB4 ERLEC1 SLC5A5 ABCA12 GPIHBP1 ABCA1 SLC6A5 LCN2 SLC6A2 SLC6A3 PSMD12 SLC43A2 PSMD11 SLC43A1 SLC2A10 PSMD14 SLC1A1 PSMD13 SLC1A2 SLC1A3 SLC3A1 ARF1 SLC1A4 PSMA7 SLC7A11 SLC1A5 PSMB6 SLC6A20 PSMD8 SLC7A10 SLC1A6 PSMB7 SLC1A7 SLC7A1 PSMB4 PSMD6 SLC7A3 RHAG PSMB5 SLC25A29 PSMD7 SLC38A3 PSMB2 SLC38A2 PSMB3 SLC38A5 PSMD2 SLC38A4 PSMD3 SLC36A1 PSMB1 SLC38A1 PSMD1 SLC6A19 SLC36A2 SLC6A15 SLC6A14 SLC16A10 ADRM1 SLC6A6 PSMA5 SLC7A6 SLC7A7 SEM1 PSMA6 SLC7A8 SLC6A4 PSMA3 SLC7A9 PSMC5 PSMA4 SLC24A1 PSMC6 SLC24A4 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SLC11A2 SLC5A6 SLC5A7 SLC10A6 AVP SLCO4C1 SLC20A2 LETM1 HDLBP ABCG8 ABCG5 ABCC6 ABCC9 PCSK6 RAB11FIP2 MYO5B SLC12A2 SLC12A4 SLC12A5 SLC9A1 SLC12A7 SLCO1B1 SLC30A3 SLC30A2 PRKACG SLC39A10 SLCO1B3 SLC2A13 SLC30A1 PRKACB SLC39A14 SLC5A11 SLC5A3 SLC39A6 SLC39A5 SLC39A8 SLC32A1 SLC39A7 SLC6A13 SLC39A2 SGK1 SLC6A1 SLC39A1 SLC15A1 SLC39A3 SLC15A3 ADCY9 SLC15A4 MB PRKAR1B NGB RSC1A1 PRKAR1A SLCO1A2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 SLC34A3 ADCY7 SLC34A2 ADCY6 SLC34A1 ADCY5 APOC1 MTTP APOC4 PRKAR2A P4HB APOB STEAP3 SLC25A18 GNAS SLC25A10 SLC35A1 SLC25A4 SLC25A11 SLC25A1 SLC22A6 SLC5A12 SLCO2B1 SLC16A2 SLC13A5 SLC13A2 SLC13A3 SLCO1C1 SLCO4A1 VDAC3 VDAC2 SLC26A7 SLC26A9 SLC26A6 SLC25A22 SLC5A9 SLC60A2 SLC30A10 SLC5A4 SLC2A14 NEDD4L SLC2A11 SLC2A12 SLC17A1 SLC13A1 SLC13A4 SLC5A10 GLTP SLC45A3 SLC20A1 SLC31A1 ESYT3 ESYT2 SLC41A2 SLC41A1 SLC2A6 SLC2A7 CPTP CLN3 SLC50A1 SLC22A2 SLC22A1 SLC6A9 SLC17A6 SLC7A5 SLC17A7 WWP1 SLC27A1 CREB3L3 PLEKHA8 NR1H2 ACO1 LCN9 SLC35B4 LCN15 LCN12 APOD SLC35A2 SLC35A3 CLTC SLC33A1 CLTA SLC35C1 ARL2BP AP2A1 LCN1 AP2B1 SLC29A4 SLC27A6 AP2A2 SLC28A2 SLC25A5 SLC29A1 AP2S1 SLC28A1 SLC29A3 SLC27A4 SLC29A2 SLC28A3 SLC25A6 STOML2 PHB1 MCUB SPG7 PHB2 MAIP1 CYGB PARL AFG3L2 SMDT1 YME1L1 MBTPS1 PMPCB PMPCA SLC36A4 MICU3 MICU2 MBTPS2 MICU1 MCU SLC9A2 SLC44A5 SLC9A3 SLC9A4 SLC44A3 SLC9A5 SLC44A4 SLC9A6 SLC44A1 SLC9A7 SLC44A2 SLC9A8 SLC9A9 CES3 RAB11A TFRC CUBN CAMK2B APOE CAMK2D CAMK2A CAMK2G SLC6A7 ADD1 RUNX1 NEDD8 RHCG RHBG LDLRAP1 PRKACA SKP1 SLC2A8 SLC2A9 ZDHHC8 UBA52 ABCD2 ABCC10 ABCB1 ABCC11 CUL1 ABCC4 ABCA10 PEX3 ABCG4 ABCB5 UBB ABCB8 ABCB9 PRKAR2B ABCF1 ABCA2 UBC ABCA5 ABCA9 ABCA7 ABCA8 RPS27A ABCB10 SLC22A3 SLC22A8 SAR1B SLC17A8 CYB5R2 ATP8A2 CYB5R1 ATP8A1 CYB5R4 ATP12A CYB5RL BEST2 CA1 SLC9C1 BEST3 CA2 SLC9C2 ALB CA4 BEST1 BEST4 SLN ATP6V1E1 ATP6V1E2 ATP6V1G1 PCSK9 ATP6V0E1 LSR LIPA ATP6V1G2 ATP11C NCEH1 ATP11B NPC1 AMN BSG SOAT1 ATP1B3 ATP11A NPC2 SOAT2 ATP1B2 ATP1B1 SLC3A2 SLC9B1 SLC9B2 SCNN1G SLC16A8 SCNN1D SLC16A3 SCNN1B MAGT1 SCNN1A ATP6V0D1 RAF1 ATP6V0D2 ATP6V1A TTYH3 TTYH2 CLCNKB SLC47A2 SLC14A1 WNK4 CLCNKA SLC14A2 SLC47A1 NALCN SLC25A26 KCNJ11 ASIC4 SLC22A15 ASIC5 CLCA2 SLC22A16 ANO8 ATP6V0A2 ANO9 CLCA1 ANO6 ATP6V0A4 ANO7 ASIC2 ASIC3 ANO4 ATP6V1D ATP6V1C1 CLCA4 ANO5 A2M ATP6V1F ATP6V1C2 ANO2 ASIC1 SLC46A1 ATP6V0A1 ANO3 ATP8B4 ATP8B3 ANO1 ATP8B2 ATP8B1 ATP4B ATP4A FXYD4 WNK1 CAND1 FXYD3 WNK2 FXYD2 WNK3 FXYD1 FXYD7 FXYD6 ANO10 CUTC PCSK5 LMF2 RYR1 LMF1 SLC6A12 RYR2 LIPC TCIRG1 SLC6A11 ANGPTL8 RYR3 ANGPTL3 UNC80 ATP7B FGF21 CLIC2 ATP6V0B TSC22D3 VDAC1 TRDN ASPH ATP6V1B2 HMOX1 SGK3 SGK2 ATP6V0C HMOX2 ATP6V1B1 STOML3 ATP10D CFTR ATP1A4 TUSC3 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ATP6V0E2 FURIN ATP6V1G3 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 VCP SLC17A5 LDLR LIPG LCAT APOBR DERL2 RNF5 NR1H3 OS9 RNF185 SLC26A11 SLC26A2 SLC26A1 ESYT1 ABCG2 FTH1 SLC8A3 ATP2B4 ATP2A3 ATP2A2 ATP2B3 ATP2A1 ATP2B2 ATP2B1 SRI CALM1 SLC8A1 FTL SLC8A2 APOA2 APOF ABCD3 APOA1 LPA SLC2A1 SLC2A2 APOA4 SLC2A3 APOA5 SLC30A8 ABCC3 ANGPTL4 ABCC1 SLC30A5 ABCC2 ABCC5 ARL2 GNG10 APOC3 GNG12 GNG11 GNG13 APOC2 SLC35B3 SLC67A1 GNB2 SLC35B2 GNB1 PEX19 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 ATP6AP1 SLC4A1 SLC16A7 EMB SLC4A4 SLC22A4 SLC22A5 SLC35D1 ADD3 SLC35D2 GNG3 GNG2 STOM GNG5 LPL GNG4 GNG7 STEAP4 GNG8 HFE SLC22A17 SLC4A7 GLRX3 TFR2 IREB2 SLC39A4 FTMT CYBRD1 SLCO2A1 TF SLC26A4 SLC26A3 AVPR2 SLC2A4 SEL1L SLC24A5 SLC22A12 SLC24A2 SLC24A3 SLC8B1 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLC40A1 HEPH AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP ABCB6 MRS2 AQP11 SLC66A1 SLC5A1 HBB ADD2 SLC5A2 NIPAL4 ANKH ABCA3 NIPAL1 ABCA4 NIPAL2 NIPAL3 ERLIN1 LRRC8C U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing SNRNP200 SNRNP48 SRSF2 SRSF6 GTF2F1 GTF2F2 SRSF7 TXNL4A SRSF1 EFTUD2 SNRNP40 DDX42 NCBP1 NCBP2 RNPC3 DDX23 ZRSR2 PRPF6 PRPF8 SNRPD2 SNRPD1 SNRPD3 PDCD7 POLR2A POLR2B SF3B1 POLR2C SNRNP35 ZCRB1 POLR2D SF3B4 SF3B5 SF3B2 POLR2G SNRPG SF3B3 SF3B6 POLR2I SNRPE SNRNP25 POLR2J YBX1 SNRPF ZMAT5 POLR2E POLR2F POLR2H SNRPB POLR2K POLR2L PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation H2AC14 EP300 H2BC12L H2AC8 H2AC6 H2AC7 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B CREBBP CCND1 H4C9 TP53 RUNX1 MAML2 MAML1 PRKCI SIRT6 H2AC20 TFDP1 TFDP2 ELF3 MAML3 ELANE H2AX NOTCH2 NOTCH3 NOTCH4 E2F1 E2F3 H2BC26 JUN NOTCH2NLA NOTCH2NLC NOTCH2NLB SNW1 H2BC21 H3-3B MAMLD1 H3C8 H2BC17 H2BC12 H2BC13 H2BC14 KAT2B H2BC15 KAT2A H2AJ H2BC11 H3C15 NOTCH1 H2BC9 RBPJ H2BC8 H2BC5 H2BC3 H2BC1 H2AC19 H2AB1 H2AZ2 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription H2AC14 H2BC12L H2AC8 H2AC6 H2AC7 CTBP2 CTBP1 ZMYM2 TCF3 SNAI1 SNAI2 TGIF2 H4C9 SMARCA4 H2AC20 FOXQ1 DNTTIP1 ZBTB33 EZH2 H2AX ZEB2 PKM ZEB1 MCRIP1 H2BC26 H2BC21 H3-3B H3C8 KDM1A TCF12 EED TWIST2 TWIST1 H2BC17 SIRT1 MAPK1 H2BC12 H2BC13 H2BC14 MAPK3 H2BC15 H2AJ H2BC11 ZNF217 TLE1 HDAC2 H3C15 HDAC1 SUZ12 H2BC9 H2BC8 H2BC5 KMT5A H2BC3 RBBP4 H2BC1 RBBP7 H2AC19 MPHOSPH8 WT1 H2AB1 H2AZ2 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AB1 HSP90AA1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids PON3 GPX2 GPX1 PON2 GPX4 ALOX5AP PON1 LTC4S ALOX5 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase PPP2R1B LYN CDKN2A CDKN1B JAK2 E2F5 CCND3 CCND2 CKS1B CDKN2D PPP2R3B CDKN2C CDKN1C SKP2 E2F2 UBA52 ABL1 CDKN2B CDK6 CCND1 CCNE2 CUL1 CCNE1 UBB PTK6 CDK4 CDK2 UBC CDK7 RBL2 RBL1 RPS27A PPP2R2A TFDP1 TFDP2 MNAT1 PPP2R1A E2F4 RB1 CDKN1A CCNH E2F1 E2F3 PPP2CA SKP1 PPP2CB BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis RHD ST3GAL3 RHCE ABO FUT2 FUT1 FUT4 B3GALT4 FUT3 B3GALT5 FUT6 B3GALT2 FUT5 B3GALT1 ST6GALNAC6 FUT7 FUT9 B4GALNT2 ST3GAL6 ST3GAL4 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) WNT1 FZD10 FZD1 ADGRE2 FZD3 FZD2 GLP1R ADGRE5 FZD5 CRHBP FZD4 FZD7 ADGRE3 FZD6 IHH FZD8 GHRHR ADM GLP2R WNT10B WNT16 GNG3 WNT10A FZD9 GNG2 GNG5 GNG4 CALCRL GNG7 PTHLH GNG8 PTH1R UCN3 UCN2 PTH2R VIP CD55 WNT8A WNT8B IAPP WNT7B CRH SCTR WNT7A ADM2 GCG WNT3A CALCA WNT9A PTH2 SHH VIPR1 VIPR2 GIPR CRHR1 SMO UCN RAMP3 PTH GIP WNT11 PTCH1 GNG10 GHRH RAMP1 WNT4 GNG12 GNAS GNG11 GNG13 GNB2 CALCB GNB1 WNT9B WNT6 GCGR CALCR GNB4 GNB3 RAMP2 WNT2 WNT3 GNB5 ADCYAP1 ADCYAP1R1 DHH PTCH2 GNGT1 WNT5A GNGT2 WNT2B SCT ADGRE1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation ST8SIA3 SEC16A CAPZB SEC23IP GOSR2 DYNC1LI1 CNIH1 DYNC1LI2 CNIH2 FOLR1 CNIH3 BET1 HK1 SPTB F5 KDELR1 CAPZA1 F8 CAPZA2 ANK2 DYNLL2 SPTBN4 SPTBN5 ACTR1A SEC31A DERL1 COPB1 LMAN1 DPAGT1 MPI STX5 YKT6 DOLK CSNK1D SPTA1 DYNLL1 DCTN1 UBA52 DYNC1I2 DCTN2 DCTN3 UBB UBC ST6GAL1 ARF3 ARF1 MOGS RPS27A RAD23B DYNC1H1 RPN2 SAR1B RPN1 MPDU1 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 GOLGA2 EDEM2 PSMC1 SEC22B GRIA1 NUS1 NSF MAGT1 PDIA3 DPM1 ARFGAP3 DPM2 DPM3 ARFGAP2 CANX MGAT5 MGAT1 MGAT2 SRD5A3 ST3GAL5 CGA KDELR2 TUSC3 COPB2 COPA SPTBN2 COPE TMED3 TMED7 SCFD1 TMED9 COPZ2 SPTBN1 COPZ1 CTSC ARF5 ANK3 TMEM258 CAPZA3 ACTR10 SLC35A1 TGFA COL7A1 CHST10 ARCN1 ST6GALNAC5 COPG2 COPG1 ST6GALNAC6 SPTAN1 VCP DCTN6 FUT8 DCTN5 DCTN4 SLC17A5 MAN2A1 EDEM3 EDEM1 AMFR SYVN1 DERL2 OST4 RNF5 RNF103 RNF139 OS9 OSTC TRIM13 STT3A UGGT2 UGGT1 RNF185 MARCHF6 STT3B ST6GALNAC2 PRKCSH DDOST DAD1 DYNC1I1 MAN1B1 ST6GALNAC3 ST6GALNAC4 SEC23A CD59 CD55 GANAB SEC24B SEC24A MGAT4C MGAT4A MGAT4B ST6GALNAC1 CMAS NPL SEC24D NANP SEC24C NEU4 UMOD ST8SIA4 ASGR1 NANS ST6GAL2 ASGR2 ST8SIA1 MANEA GNE ST8SIA5 NAPA CTSA B4GALT2 SEC13 B4GALT3 GOLGB1 CTSZ ALG8 ALG9 ALG6 ALG2 ALG3 ALG1 ANK1 CALR B4GALT6 B4GALT4 B4GALT5 MAN1A2 DHDDS MAN1C1 MAN1A1 TFG FUT3 GLB1 LHB UBXN1 NGLY1 MLEC ENGASE TRAPPC2L TBC1D20 B4GALT1 AREG SLC35C1 TMED2 SEL1L TRAPPC2 TRAPPC3 TRAPPC1 ST3GAL6 COG1 TRAPPC4 TRAPPC5 MIA2 MIA3 MVD ALG5 NUDT14 NAGK GFPT2 ARF4 AMDHD2 TRAPPC9 GFPT1 TMEM115 PGM3 GNPNAT1 INS UAP1 RENBP ALG14 ALG13 ALG12 ALG11 TRAPPC6A GMPPB TRAPPC6B FPGT ARFGAP1 GMPPA GFUS ALG10 RAB1A ALG10B FUOM RAB1B DHRSX GMDS PMM1 FCSK DOLPP1 PREB RFT1 KDELR3 TRAPPC10 GBF1 MCFD2 SERPINA1 GOSR1 NEU2 PPP6C NEU3 PPP6R1 PPP6R3 LMAN1L NEU1 GORASP1 SEC22A SEC22C NAPB TMED10 COG8 LMAN2L B4GALNT2 COG7 STX17 COG6 USO1 MAN2A2 COG5 NAPG MGAT3 COG4 ST8SIA6 LMAN2 COG3 SEC31B CHST8 COG2 FUCA1 PMM2 ANKRD28 ST8SIA2 SEC16B BET1L DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex APC TCF7L2 MEN1 WDR5 SOX9 CTBP1 CTNNB1 XIAP KMT2B UBA52 SOX3 SOX6 SOX7 SOX4 AKT2 SOX13 TLE4 XPO1 TLE3 TLE2 AKT1 TLE1 CHD8 PYGO1 UBB PYGO2 TCF7 HDAC1 YWHAZ LEF1 UBC BCL9L CTNNBIP1 BCL9 CBY1 SRY RPS27A RBBP5 SOX17 BTRC DPY30 ASH2L TCF7L1 SOX2 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions LIFR JAK1 CNTFR JAK2 TYK2 IL11 CNTF OSMR LIF IL6ST CRLF1 CTF1 CLCF1 IL31 IL11RA IL31RA OSM SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways ATF1 ELK1 RPS6KA3 SCD RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MEF2C MAPKAPK3 MAPK8 SHC3 PTPRA SPTB CCR6 CCR2 SPTBN4 GRIN2B SPTBN5 COL1A2 S100A9 S100A8 NRP2 GFRA3 HEY1 HEY2 SPTA1 LAMA1 SPARC SKI PTPRS PSMD12 PSMD11 NOTCH1 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMB6 PSMD8 UBE2D3 LFNG PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 LAMC3 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 ITGA3 PSMC4 PSMC1 PSMC2 CTNNB1 LAMA2 LAMA4 LAMB2 FOXO6 FOXO4 FOXO3 FOXO1 YWHAB HSPB1 XPO1 AKT1 PRKCD PRKCA YWHAZ MAPKAPK2 GNAT1 MAPK14 PPM1A MAPK11 ITGA5 EIF4G1 IFT172 GLI1 GLI3 GLI2 IFT52 SUFU PRKACG E2F5 IFT57 PRKACB DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 SST RBX1 IL2RA IFT88 ADCY9 PRKAR1B SMO PRKAR1A GPR161 STUB1 NUMB INTU ADCY4 TRIM33 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 WDR19 IFT122 FUZ ADCY10 ITCH GNAS MKS1 TGFA WWTR1 YES1 SPRED3 SPRED2 SPRED1 SYNGAP1 YAP1 HRAS RASA3 RASA4 RASA1 RASA2 RXRG CUL3 RASAL1 RASAL2 VEGFA RASAL3 NRAS DAB2IP NF1 KBTBD7 IHH CCND3 C3 CCNK CCNT2 NUP107 CCNT1 IL2 IL3 BMP2 TCF3 TGIF1 GTF2F1 GTF2F2 TGIF2 SERPINE1 JUNB NEDD4L AAAS RNF111 NUP160 NUP85 CDK9 RARG RSPO3 NELFB TCF12 CCR5 RARB SEC13 NCBP1 NUP133 NCBP2 RANGAP1 GTF2A1 GTF2A2 CDKN2B WWP1 CXCR4 POLR2A POLR2B TAS2R20 POLR2C POLR2D PF4 POLR2G CSF2 NUP43 POLR2I ITGA2B POLR2J RANBP2 TAS2R10 TAS2R13 TAS2R14 TAS2R16 NUP37 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SKIL CHUK TAS2R30 TAS2R31 IKBKB TAS2R38 TAS2R39 IKBKG FKBP5 NTRK1 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 CRH DNM3 AP2S1 DNAL4 SH3GL2 AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB FRAT1 FRAT2 TAS2R50 APC PPP2R1B PPP2R5E CDC37 ERBIN PHB1 SOX9 CITED1 PARP1 ITGB1 RET NPY CAMK4 GATA3 FGF2 ATP1B4 KCTD6 WNT11 SMAD2 SMAD1 MECOM SMAD4 SMAD3 SMURF2 SMURF1 SMAD6 WNT4 ESR2 SMAD7 NR4A1 JAG1 NR2E1 WNT9B YBX1 GFRA1 OPRM1 CAMK2B CAMK2D CAMK2A THBS1 GDNF HES1 CAMK2G ITGA8 ID4 ALK CD274 OPRK1 IRS1 PIK3R2 PTN PIK3CB PIK3R1 PRDM1 IL2RG HIF1A PTPRZ1 MDK MYC ALKAL2 ALKAL1 JAK3 FRS2 MYCN PIK3CA PTPN6 ITGB3 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A FGB TNRC6B FGA TGFB1 FGG CCND1 F2R CBFB F2 KRAS F3 RUNX3 RUNX1 TAS2R7 TAS2R8 KNG1 WWOX PRKX GRM4 UBE2D1 TAS2R1 TAS2R3 RELA TAS2R5 TAS2R4 TCF7L2 NFKB1 IL6 THBS2 GJA1 TBK1 AKT2 AKT3 TAS1R2 TAS1R1 TAS1R3 GALNT3 GOLGA7 MUC20 PLAT PIK3R4 ST3GAL4 SFN DUSP5 DUSP2 DUSP1 ST3GAL3 PAQR3 PTPN7 PTPRJ ATP6V1E1 ATP6V1E2 ATP6V1G1 RPS27 ATP6V0E1 ATP6V1G2 ZRANB1 NRP1 ATP6V0D1 RAF1 ATP6V0D2 ATP6V1A IKBKE JAK1 PRMT1 RIPK2 ATP6V0A2 ATP6V0A4 TYK2 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 GPC5 TCIRG1 STAT1 ATP6V0B TJP1 ATP6V1B2 ZDHHC9 ATP6V0C ATP6V1B1 SHC2 RALGDS PTPRO RALB KPNA2 MAPK13 MAP3K7 RIT1 RIT2 CHRM2 CHRM4 ADRB1 ADRB2 HTR4 HTR6 TAAR3P HTR7 ATP6V0E2 RPS6 ATP6V1G3 HRH3 HRH2 HRH4 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A HTR1B TAAR5 TAAR2 HTR5A TAAR1 ADRB3 CGN F11R FKBP1A VCP DDX5 PARD3 IRAK1 CYSLTR1 SCT CYSLTR2 RXFP4 MRGPRD GNAT3 GNAZ FZD10 RXFP1 RXFP2 SYK RXFP3 CRHBP CAV1 GPR176 ADORA2B CMKLR1 AGTR2 GNAI3 FYN FPR1 FPR3 GHRHR TAB3 OPN1SW TAB2 GALR3 MKNK1 TAB1 GALR2 GALR1 SPRY2 NPBWR1 NPBWR2 GSK3A WNT10B HSP90AB1 WNT10A GPR15 MYD88 FZD9 YWHAQ GPR183 PNOC GPR18 YWHAH PDPK1 GPR27 GPR25 IRAK4 GPR20 TLR9 PTH1R UCN3 UCN2 GPR37 TRAF6 GPR35 GPR32 PIK3C3 GPR31 PTH2R RGR PLPPR1 GPR45 S100B SAA1 PLPPR2 PLPPR3 TGFBR3 GIPC1 PLPPR4 PLPPR5 WNT8A VHL WNT8B GPR150 P2RY12 P2RY13 WNT7B UHMK1 PTPN11 EPGN P2RY14 GPR55 SCTR ARRB1 WNT7A ADM2 MTNR1A MTNR1B GPR83 GPR84 ATP2A3 RLN2 ATP2A2 RLN3 ECE1 ECE2 ATP2A1 PRLHR INSL3 INSL5 PTH2 CALM1 P2RY4 APLN VIPR1 VIPR2 RRH OXER1 PTGDR GPR37L1 TAS2R19 KEL TAS2R42 GIPR TAS2R45 CRHR1 NLN PENK PPY PPP1R1B PDE3A TAS2R60 PTGDR2 RGS9 PPP3CC RGS6 OXGR1 RGS7 GPBAR1 GAL PTGER4 OPRD1 NPB RAMP3 PTH PTGER2 PTGER3 CCNE1 CSF2RB NPW PRLH CSF2RA MAS1 ARL2 XK GNG10 GHRH RAMP1 CCL4L2 NPY2R RGS8 GNG12 PDE8B GNG11 PDE8A GNG13 NPY1R PCP2 CCT6A GNB2 APLNR GNAQ CALCB GNB1 IRS2 SUCNR1 WNT6 GRK3 GNB4 CALCR GRK6 GNB3 WNT2 GNB5 WNT3 SOCS1 OPN3 GNAT2 PTCH2 PRKCG OPN5 WNT5B PYY GNGT1 WNT5A GPSM1 GPSM2 TUBA1B ROR1 ROR2 GNGT2 TAS2R9 WNT2B NLK ADGRE1 PPP3R1 GRM3 CCT2 WNT1 FZD1 HEBP1 SPHK1 ADGRE2 FZD3 GRM2 FZD2 ADGRE5 FZD5 GRM7 FZD4 GRM6 FZD7 ADGRE3 FZD6 GPER1 FZD8 GNAO1 GRM8 CLTB PDE4A GPSM3 ARRB2 PPP3CA PTGIR PPP3CB NPY5R PRKG1 PDE4D PRICKLE1 GLP2R GNA14 PDE4C PDE6B SSTR1 PDE6A GNG3 WNT16 PDE6G GNA15 SSTR2 RYK SSTR4 GNG2 SSTR5 GNG5 CORT GNG4 RGS14 GNG7 NPY4R GNA11 OPRL1 GNG8 PTHLH CNR2 CNR1 CCT7 RGS20 S1PR3 RGS22 S1PR2 S1PR5 RGS11 S1PR4 RGS10 RGS12 PDE7B ACKR1 B4GALT1 POGLUT1 VIP MAML2 PDE7A MAML1 POFUT1 SRY TMED2 DISP2 PRKCI SCUBE2 SIRT6 NOTUM TFDP1 TFDP2 ELF3 MFNG MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 ST3GAL6 E2F3 RAB6A JUN NOTCH2NLA NOTCH2NLC UBE2L3 NOTCH2NLB SNW1 MAMLD1 MAPK7 MAP2K5 CDKN1B LRRK2 ARHGAP35 RAC1 PELP1 NRG1 ARAP1 NRG2 RHOA EREG BTC IL2RB DOK1 SFPQ NRG3 NRG4 ELMO1 ELMO2 DOCK1 CRK HBEGF KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN CBL SOCS3 GPNMB STAP2 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 TAX1BP1 CAB39 FASN NEDD4 RAG2 RAG1 MYLIP TEC SRRM1 DDX39B RNF41 IL5RA CUL5 RAB4B TRPC7 MKRN1 TRPC6 TRPC3 UBE2M TRADD TNFRSF10B FASLG TNFRSF10A TRAF2 CASP8 TNFSF10 FAS RIPK1 FADD UBE2D2 PTPN2 PRKCQ RASGRP2 RASGRP1 RASGRP4 DRD1 DRD2 DRD3 DRD4 DRD5 LYN NFKBIA DLG1 ADORA2A ADORA3 ADORA1 PDGFRA TIAL1 PTBP1 FGF6 RBFOX2 HNRNPH1 ESRP2 ESRP1 HNRNPA1 TIA1 HNRNPM CTNND1 RACK1 EPS15 PRKCE IL3RA PCSK6 TIAM1 NTRK2 BDNF CDK5R1 TGFBR1 TRAF1 TGFBR2 MAP2K1 MAP2K2 RAP1A RAPGEF1 MAPK1 BRAF CRKL MAPK3 ABHD17C FGF1 USP17L2 FRS3 ABHD17B FGF4 ABHD17A FGF16 RCE1 FGF9 FGF18 FGF20 SOS1 FGF23 APOC1 APOC4 P4HB BUB1B CDC20 BUB3 MAD2L1 PRKAB2 CASP9 PDE1B PDE1A PDE2A PDE11A PDE10A SHMT2 RDH11 PIP5K1A PIP5K1B PIP5K1C OPN1MW SQSTM1 FLT3 TRIM27 USP13 TNKS TNKS2 RNF146 FRK PRKAG2 OTUD3 CAMKK1 CAMKK2 C3AR1 SMPD3 SMPD2 WDR83 RGL3 RGL2 PEA15 IL17RD RAPGEF2 RAPGEF3 SEPTIN7 CDC14A PPARD EIF4E CDC14B RAPGEF4 EIF4B RASGEF1A ETV4 IGF2BP1 MAPK6 MAPK4 ACTN2 GABRG3 GABRG2 GRIN2D GNAL DLG2 DLG3 NBEA GABRB3 GABRB2 GABRB1 RASGRF1 NEFL LRRC7 PGK1 FGFRL1 GABRQ GABRA1 GABBR2 GABBR1 SP1 GRIN1 PTEN IAPP MCHR1 NPHP4 PRKAA2 SSTR3 PDE6D TRIB3 RHO NTF3 APOE PCK1 AMHR2 CER1 FST FOXH1 ZFYVE16 LTBP4 CYP26A1 PSEN2 LTBP2 LTBP3 LTBP1 APH1A APH1B TGFB2 TGFB3 GDF2 SMAD9 INHBB INHBA SMAD5 DRAP1 BAMBI MYF6 TCF4 BMPR1B BMPR1A MYF5 ACVRL1 BMP10 BMPR2 ITGB5 CHRDL1 ITGB8 PMEPA1 ITGAV ITGB6 AMH MYOG PSENEN HELLS NOG KLF16 UCHL5 GREM2 MYOD1 STRAP PPP1R15A USP15 NEDD8 ACVR1B FSTL1 FSTL3 ACVR1C GNAI1 ACVR2B GNAI2 ACVR2A INHA HCAR2 HCAR3 HCAR1 GCG FOXA1 SMC3 FKBP4 RAD21 JUND GREB1 STAG1 STAG2 CXCL12 SMC1A TFF3 CFLAR TFF1 KANK1 CXXC5 NRIP1 USF2 USF1 ZNF217 FOSB EBAG9 ANGPT1 SHC1 TEK PDHA2 PDHA1 EVC2 IQCE EFCAB7 EVC DRC4 SPPL2B SPPL2A CLIP3 NSMAF OTULIN TNS4 TNS3 CYP26B1 CYP26C1 INSR GRB10 GZMB COL4A5 EIF4EBP1 CARM1 PDE1C GRK2 EEF2K TPH1 CAB39L ADH4 STRADA STRADB COL4A2 COL4A1 COL4A4 CGA COL6A2 HMOX2 COL4A3 COL6A1 COL6A3 COL6A6 COL6A5 PLIN3 THBS4 THBS3 PDGFD CKB SYVN1 DERL2 NR1H3 OS9 PPP1CC IER3 FLT3LG ULK3 PDGFB DZIP1 CD19 SPOPL EGR1 SNAI1 CD28 SNAI2 STRN GAB2 PHLPP2 PHLPP1 IL33 CSNK1G2 CD86 KLB CD80 ATN1 SALL4 MAF1 PDGFRB FGF19 FGFR4 AKT1S1 IL1RL1 TRAT1 RPS6KB2 PIK3AP1 RAB4A SNX3 ADRA1D ADRA1B USP34 ADRA1A TBXA2R GNA12 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 JAG2 FN1 PRKG2 SHH DUSP8 LBR DUSP9 NEURL1B HHAT FNTA FNTB PDHB UGT1A3 KDR MC2R GRB2 VEGFB VAPB VEGFC VEGFD APOC2 CNKSR2 CNKSR1 PEBP1 IGF1R IL6R PDK3 PDK2 PDK1 PDHX ZDHHC7 CAV2 TIAM2 CTBP2 CTBP1 LHB APBB1IP GFAP ADH1C AVPR2 ADH1A ZDHHC21 TLN1 PTGES3 PGF SH2D2A FLT1 SHB HES5 ARAF DHH GLP1R HEYL DBT PORCN ALDH1A1 KSR1 KSR2 LRP5 LRP6 AATF MAGED1 NOS3 MIB1 SH3GL3 SH3GL1 MTMR1 VCL IQGAP1 MTMR4 ERLEC1 DKK1 DKK2 DKK4 ABCA1 BRAP OPN1LW MRAS LYPLA1 RNF43 BAG4 DUSP16 DUSP10 CX3CR1 DLD PTPN12 SH3KBP1 AVPR1B KREMEN1 AVPR1A KREMEN2 RDH5 AVP SHOC2 AXL LETM1 ABCG8 ABCG5 FABP5 FABP6 FABP7 MARK3 DLL4 STK11 S1PR1 NEURL1 PDE3B IDE PTPRF SPOP PRDM4 DTX1 DTX2 DTX4 DNER DLK1 CNTN1 THEM4 IRS4 VPS29 SOX3 VPS35 SOX6 PIK3CD SOX7 PIK3CG SOX4 WLS SOX13 HECW1 VPS26A CCDC88C RSPO2 RSPO1 RSPO4 TMED5 LGR6 LGR5 LGR4 CTNNBIP1 KLHL12 CBY1 DACT1 CXXC4 ZNRF3 LTK TNK2 CRABP2 AHCYL1 SPINT1 MST1 HPN SPINT2 MST1R PIK3R3 PIK3R6 PIK3R5 CILP GRAP PPID AMOTL2 AMOTL1 MXD4 MEMO1 CSN2 SAV1 PTPRU STMN1 ADAP1 MOB1B MOB1A BEX3 STK4 STK3 FER LATS1 LATS2 RGL1 WASL RXRB GCGR AKR1C3 PPP1CA ULK1 MTR NDUFS3 INS ARF6 PIP4K2A GGA3 PIP4K2B PIP4K2C MC4R EDNRB EDN1 EDN3 MC3R PLCG2 MC1R ID1 MC5R NPFFR2 NPFFR1 NPFF QRFPR HCRT QRFP HCRTR2 HCRTR1 PLCB3 PLCB4 PLCB1 PLCB2 AGT CHRM3 OXTR RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R PRKCH TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 ITPR1 ITPR2 NTSR1 NTSR2 GPR17 ITPR3 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 MLN PSAP BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 GAST FFAR2 GPR39 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 ADRA2C GPR143 ADRA2A MT-RNR2 F2RL1 F2RL2 F2RL3 DGKG DGKE DGKD CHRM1 DGKB GPR68 DGKA GPR65 PMCH CHRM5 ABHD12 RGS4 PTPN13 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ LTB4R2 DGKQ UTS2 DGKK DGKI DGKH ABHD6 NTS MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2C OXT HTR2A TRH GRM1 LTB4R GRM5 BDKRB2 BDKRB1 GNRHR2 XCL2 XCL1 DAGLB RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK KISS1 GIP LEP HHIP BOC GAS1 CDON NGFR PTPRK EPS15L1 EPN1 ADAM12 LRIG1 FAM83D AAMP PAG1 FAM83A SPRY1 PTPN3 FFAR1 DLAT ICMT TLE5 SORCS3 C5AR2 C5AR1 C5 RANBP9 CD55 OCRL MEF2D ACBD5 ANOS1 GRAP2 ABCD3 UCN TSHB FSHB CRHR2 IGF1 POMC APP RAP1B HGF DOCK7 GAB1 MET AREG FES FGFBP1 FGF7 FGFBP2 FGFBP3 FGF22 MAPK12 FGF3 FGF10 TCF7L1 WNT3A PTPN18 USP8 SOX2 MATK WNT9A SFRP1 MYB SFRP2 WIF1 TSC2 SOST TSC1 KDM1A DOCK10 DOCK11 KIF5B KIF5A KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF18A RCOR1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CAPZB CXCL6 CXCL9 CXCL8 CXCL1 JAK2 CXCL13 CXCL3 CXCL2 CX3CL1 CXCL5 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 KIF2A CCL13 CCL11 CCL3L3 KIF2C CXCR5 KIF2B CXCR6 CCL7 DOCK2 CXCR1 CDC42 CCL5 MFN1 CXCR3 MFN2 CCL4 SH2B3 CXCR2 CCL2 SH2B2 CCL1 CCL19 CCL17 CENPE CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 CCL27 LHCGR TSHR FSHR GPHA2 GPHB5 CETP ARL4C EEPD1 ABCG1 HGS ATP6V1H RAB7A RALA LMNB1 CFL1 PAK2 HNRNPF CHD8 IGF2 PDYN SLC1A5 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 KAT5 CHEK1 PRKAB1 RRAGA RRAGC RRAGB RRAGD MAPKAP1 CDKN1A PRKAG1 PRKAG3 RPTOR NAB1 NAB2 LYL1 CASP10 ARC VGF TRIB1 RRAD ASCL1 EGR2 EGR3 EGR4 FOS FOSL1 ID2 ID3 SGK1 CDK5R2 RICTOR SPTBN2 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 USP7 USP2 CDC25C MAPKAPK5 SLC38A9 TNFRSF10D RHEB MDM2 PIN1 PRR5 DNAJB1 MLST8 CASP2 RBL1 BIRC5 PRKAA1 AURKB E2F4 MTOR PML BAX HDAC10 TRRAP ITGA2 KDM1B RUVBL1 CRABP1 DHRS3 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH16 RDH14 RDH13 ALDH8A1 HDAC4 NR1H2 NR3C1 ESR1 AR RXRA RARA PPARG KDM3A PGR HDAC8 KDM4A KDM4B KDM4C TP53 REST APOD CSNK2A1 CSNK2A2 DDX4 ROCK1 TNFAIP1 ARHGAP5 CSNK2B RND3 ARHGAP21 MUC13 WDR6 FLOT2 FAM83B DSP ANKRD26 DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 PLD1 CKAP4 KTN1 PLD2 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM KIT FLT4 NTRK3 VWF ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 TRIO TFRC WIPF1 WIPF2 PLA2G4A ITSN1 WIPF3 STMN2 RAMP2 FNBP1L MYLK PREX2 PREX1 WDR91 EPSTI1 ANKFY1 CEP97 MGLL FNBP1 PRKCB STARD8 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 DAAM1 WDR81 MYL9 NGEF CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 ADM SKA2 ABR RHOT2 RHOT1 MYO6 NCKAP1L STARD13 EPO JUP CDH5 MCAM FAM135A NOX3 GPAM CALCRL HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARHGAP8 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 EGF NUF2 ERBB2 PLCG1 EMD EGFR NUDC RRAS2 YWHAE GMIP DYNLL2 LRRC41 CCP110 CIT PPP1CB CDC42EP5 INCENP CDC42EP4 CDC42EP3 PPP2R1A CDC42EP2 CDC42EP1 VAMP3 PKN3 BTRC GPS1 PRKACA CENPA FGD1 FGD2 CENPC YWHAG FGD3 LMAN1 SKP1 FGD4 FGD5 OFD1 HSP90AA1 CHN2 CHN1 FLNA STX5 PPP1R12A YKT6 FARP2 CENPT FARP1 RASGRP3 CENPU KIDINS220 USP9X MCF2 PPP5C CSNK1E WWP2 DEF6 WDR11 DYNLL1 TMEM59 CKAP5 CENPF TAOK3 ABI2 CENPH VMA22 CENPI MAPRE1 SHKBP1 TAOK1 UBA52 ABI1 OPTN CENPK PAFAH1B1 CENPL CENPM DYNC1I2 GOPC FILIP1 PKN2 CENPN PKN1 CENPO CUL1 CENPP CENPQ CENPS PLXND1 UBB NCF1 PRKAR2B FAM13B NCF2 UBC FAM13A NCF4 MSI2 STK10 SLK POTEE RPS27A GOLGA8R TPM4 CLASP1 RALGAPA1 TPM3 DYNC1H1 SWAP70 VRK2 FAM91A1 NDE1 TEX2 PLK1 SOX17 ARMCX3 ADCYAP1 CLIP1 ADCYAP1R1 OBSCN PHIP MAD1L1 FLRT2 RHOBTB3 CDK1 LIN7B FLRT3 FLRT1 RHOBTB1 BCL2L11 RHOBTB2 STIP1 BAD DDRGK1 STAT3 ADRA2B PBX1 BCL2 STK38 DLGAP5 DVL1 DVL2 FCER2 TACC3 PLXNA1 DVL3 WWC1 BCL2L1 PTCRA ABL2 ACTA2 SRGAP3 SRGAP2 SRGAP1 ARPC4 LINGO1 ARPC5 MAG NDC80 OMG COPS4 RTN4 NSFL1C ARPC2 ARPC3 CDH1 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ARHGAP11A ZNF512B ARHGAP11B RASGRF2 SNAP23 BRK1 TAGAP ADAM10 EFHD2 NCK2 SPDL1 ADAM17 NCK1 PLEKHG3 ACTR3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 PSEN1 NIPSNAP2 KLK2 ARFGAP2 LCK DSG2 EVL NCSTN PPP1R12B SOS2 BLTP3B SRC ROCK2 ELANE SRF SOCS6 NSL1 COL9A1 PARD6B COL9A3 PARD6A COL9A2 SH3BP1 ARL13B SLITRK3 LAMC2 NHS SLITRK5 LAMC1 CSK RBBP6 WHAMM WASF1 WASF2 WASF3 RNF20 PPP1R14A PCDH7 CASP3 PCSK5 CDC42BPB TIMP2 CDC42BPA BAIAP2 MYO19 TIMP1 ANGPTL3 PRC1 CPNE8 GOLGA3 BAIAP2L2 CTSD BAIAP2L1 OPHN1 MMP7 TMPO ACTN1 KNL1 MMP2 ZW10 MMP3 SPATA13 BTK HGFAC MMP9 PFN1 CFTR ROPN1 PFN2 MMP14 GRB7 TMEM87A MMP16 GARRE1 TWF1 KLK3 KALRN MYL12B SCFD1 LAMA5 DSN1 SCAI SPTBN1 LAMA3 PLG RCC2 FURIN STAM PTK2 ZWINT NET1 SPP1 ANLN AHCTF1 LAMB3 FAF2 KIF14 CMA1 SH3RF1 LAMB1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC2 RAC3 SPTAN1 GIT1 NDEL1 VAV3 H2AC19 RHOG RHOH CCNC RHOF RHOC ACTB RHOD VAV1 VAV2 H2AC14 RHOB H2BC12L ARHGEF9 CTTN RHOJ ARHGEF3 PDK4 ARHGEF4 TAX1BP3 ARHGEF1 MED1 RHOU RHOV ARHGEF2 ARHGEF7 DBN1 ARHGEF5 RHOQ ARHGEF6 AMIGO2 MIS12 WAS NOXO1 TRAK1 TRAK2 PAK1 SAMM50 PGRMC2 PLEKHG4B CTNNA1 EMC3 PAK6 CREBBP PAK3 DYNC1I1 H4C9 PAK5 PAK4 BCAP31 IL32 GIT2 MTX1 CAVIN1 MYO9B MYO9A SMARCA4 MPP7 DLC1 TRIP10 RAB9A ESYT1 H2AC20 B9D2 RAB9B SPC24 TJP2 EZH2 SPC25 ERCC6L H2AX RTKN PRAG1 ZWILCH ASH2L ARHGDIG ARHGAP39 ACTG1 SYDE2 ARHGAP44 SYDE1 ARHGAP42 CALCA ARHGAP40 BASP1 ARHGDIA ARHGDIB H3-3B NCOA1 KNTC1 NCOA2 ARHGEF40 H3C8 RALBP1 CYBB CYBA KCTD3 NCOA3 ARHGAP45 ALDH3A2 SGO1 SGO2 STAM2 ARHGEF26 RANBP10 ARHGEF25 ARHGEF28 ARHGAP19 NCOR2 ARHGAP18 ARHGAP17 KAT2B ARHGAP15 KAT2A PMF1 TOR1AIP1 H2AJ ARHGAP12 NR5A2 ARHGAP22 NCKIPSD NCOR1 ARHGAP20 RHPN1 MYH14 MYH11 RHPN2 ECT2 MYH10 PLIN1 CPSF7 ARHGEF39 GPS2 H3C15 ARHGAP29 MACO1 TBL1X ARHGAP28 ARHGAP27 MBD3 ARHGAP26 SUZ12 ARHGAP25 H2BC9 ARHGAP24 H2BC8 ARHGAP23 H2BC5 ARHGAP33 ARHGAP32 H2BC3 DIAPH1 DIAPH2 H2BC1 ARHGAP31 DNMBP ARHGAP30 DIAPH3 DLG4 SOWAHC GATAD2B ARHGEF10L RND2 GATAD2A RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ATP6AP1 H2AB1 ARHGEF17 ARHGEF16 EP300 ARHGEF19 ARAP2 ARHGEF18 ARAP3 MEN1 SENP1 ARHGAP10 H2AC8 ZAP70 GFOD1 ALS2 H2AC6 H2AC7 PEAK1 PDE5A ITGB3BP CCDC187 RAP1GDS1 TBL1XR1 MOSPD2 FAM169A ADD3 UACA GNA13 DNMT1 TRA2B PTK2B KMT2B STOM BUB1 CLASP2 EPOR SPEN LIMK2 LIMK1 HSPE1 SLC4A7 ABL1 FMNL3 FMNL1 ACTC1 FMNL2 VIM HDAC11 BMI1 TNF YY1 CDK8 RING1 CDK5 HDAC5 HDAC9 RNF2 HDAC6 HDAC7 GSK3B CCL3 STAT6 STAT5A DPY30 CBX8 STAT5B CHD4 PHC2 CHD3 CBX6 PHC1 POU2F1 H2BC26 CBX4 CBX2 SIN3A NFATC1 H2BC21 PHC3 IL5 WDR5 TBP EED H2BC17 RNF31 TNFAIP3 XIAP H2BC12 OTUD7B H2BC13 SPATA2 H2BC14 SHARPIN H2BC15 USP4 USP21 MIB2 TNFRSF1A H2BC11 CYLD RBCK1 OTUD1 BIRC2 BIRC3 CDC73 NRTN TLE4 TLE3 NCAM1 TLE2 TLE1 HDAC2 AXIN2 PSPN PYGO1 GFRA2 PYGO2 HDAC3 GFRA4 TCF7 ARTN TERT HDAC1 LEO1 BCL9L BCL9 H3-4 MTA1 RBBP4 RBBP5 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L H2AZ2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma EPGN EGF PLCG1 AREG EGFR HBEGF TGFA EREG BTC GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense GBP3 GBP5 FURIN FNTA FNTB PIM1 GBP2 GBP1 GBP4 CASP1 PGGT1B ACTG1 ACTB SFN OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency OTC SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination NAB2 TEAD1 PRX HMGCR EGR2 MAG SOX10 POU3F2 LAMA2 HDAC2 SCD5 SREBF2 CYP51A1 SMARCA4 DRP2 MBP LAMB1 DAG1 WWTR1 ADGRV1 UTRN POU3F1 PMP22 LAMC1 YAP1 MPZ ADGRG6 NAB1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins NUP62 RAN NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 RCC1 RANGAP1 NUP50 NPM1 NUP54 NUP210 NUP93 XPO1 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 RANBP1 NUP153 KPNB1 NUP35 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ10 KCNJ1 KCNJ16 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance DAXX ATRX TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PPP2R1B VCL NFKB1 STAT1 NFKBIA CAPNS1 CAPNS2 ITGB3 CAPN2 ANXA2 ITGB1 CHUK GNA11 ITGAV ABL1 IKBKE IKBKB PTPN1 PIEZO1 IKBKG PTK2 PPP2R2A GNAQ PPP2R1A RELA YAP1 PPP2CA ITGA5 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR4N5 OR2J3 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 ADCY3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 LDB1 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR1Q1 OR2S2 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 GNAL OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 EBF1 OR52M1 OR10V1 OR4C12 OR2AT4 OR4C11 OR6C6 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 CNGA2 OR8K1 CNGA4 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR10K2 OR4F4 OR2B2 OR4F3 OR10K1 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP2 OR52J3 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR2G6 OR5M9 OR51F1 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 ANO2 GNG13 GNB1 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling GNAT3 POMC GNAI3 PDE4A PPP3CA PPP3CB PDE4D PDE4C GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 AHCYL1 PRKCD PRKCA CDK5 CAMKK1 CAMKK2 GNAI1 GNAI2 PPP2R1A PRKX PLCB3 PRKACA PLCB4 PPP2R5D PLCB1 PLCB2 PDE1C PPP2CA PPP2CB GRK2 CALM1 PPP2R1B PRKACG PRKACB MAPK1 ADCY9 PRKAR1B PPP1R1B PRKAR1A PPP3CC ADCY4 ADCY3 KPNA2 ADCY2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNG10 PRKAR2B PDYN GNG12 GNAL GNG11 GNG13 NBEA GNB2 GNAQ ITPR1 GNB1 PLA2G4A ITPR2 OPRM1 CAMK2B GNB4 ITPR3 GNB3 CAMK2D GNB5 CAMK2A PRKCG GNGT1 PPP1CA CAMK2G GNGT2 PDE1B PDE1A PPP3R1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation RNF19B UBE3A UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 S100A1 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 TRAIP RNF41 KLHL42 ITGB5 UBE2V2 CUL7 CUL5 FGB UBA6 ITGAV FGA UBA5 CUL2 FGG UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 ERAP2 BTBD1 ERAP1 TAP2 LONRF1 TAP1 UBE2F UBE2H TAPBP UBE2B LRRC41 KLHL25 TLR1 ZBTB16 GLMN KLHL21 SEC31A KLHL22 UBE2A S100A9 BTBD6 FBXO30 VAMP3 S100A8 KLHL20 TLR2 FBXO31 BTRC UBE2W UBOX5 UBE2D1 MKRN1 ANAPC10 UBE2U RNF182 ANAPC11 UBA3 SKP1 UBE2O FZR1 CDC23 TPP2 CDC26 BLMH CDC27 UBA1 UBE2K UBE2M ANAPC7 TRIM71 FBXW11 UBE2C RNF14 KBTBD13 UBE2E1 UFL1 UBE2Q1 UBE2Q2 UBE2S TRIM69 CDC16 UNKL ANAPC4 LY96 DTX3L ANAPC5 PJA2 ANAPC1 PJA1 ANAPC2 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 ASB13 ASB14 CD14 RNF6 ASB11 UBA52 TLR4 ASB12 UBE2D2 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P PSME2 ASB16 CUL1 FBXL20 B2M ZNRF1 ZNRF2 PSMD12 HECTD1 PSMD11 UBB HECTD2 MRC1 NCF1 HECTD3 PSMD14 ASB10 NCF2 PSMD13 TRIM41 HLA-H UBC RNF25 NCF4 FBXL19 HLA-B FBXL18 HLA-C CDC34 PSMA7 FBXL15 FBXL16 HLA-A PSMB6 RPS27A FBXL13 PSMD8 ATG14 UBE2D3 FBXL14 HLA-F FBXL12 HLA-G PSMB7 TRIM39 HLA-E PSMB4 ASB8 PSMD6 ASB9 PSMB5 LNX1 PSMD7 ASB6 PSMB2 ASB7 SAR1B PSMB3 TRIM36 PSMD2 ASB4 PSMD3 TRIM37 PSMB1 ASB5 PSMD1 PIK3R4 ASB2 ASB3 TRIM32 ASB1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSME1 PSMC5 CD207 PSMA4 PSMC6 FCGR1BP SEC61A2 MRC2 PSMC3 PSMA1 SEC61A1 SEC61G PSMA2 SEC61B PSMC4 PSMC1 SEC22B PSMC2 PSMB10 PSMB8 PSMB9 SNAP23 TRIM4 PDIA3 FBXO32 CANX TRIM63 CTSV STX4 CTSS RBBP6 CTSL RBX1 BTK STUB1 CDC20 ITCH SH3RF1 UBE2V1 CUL3 KBTBD7 UBE2N FCGR1A MYD88 HMGB1 PIK3C3 BECN1 NEDD4L SEC23A RNF111 VHL SEC24B SEC24A RNF34 SEC24D SEC24C VAMP8 CD36 ELOB CYBB ELOC CYBA SEC13 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 WWP1 CALR FBXL3 FBXL5 SOCS1 SKP2 CHUK UBA7 HSPA5 UBE2L6 HERC5 IKBKB IKBKG TIRAP LRR1 CCNF KEAP1 CBLB UBE2L3 DCAF1 HERC4 RNF115 HERC3 RNF114 HERC2 HERC1 FBXO7 TRIM21 HERC6 TLR6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 MIB2 ATG7 HACE1 RBCK1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 SOCS3 DZIP3 FBXL7 KCTD6 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B SMURF2 GAN SMURF1 PRKN RNF138 RNF130 HUWE1 KLHL2 UBE2G1 KLHL3 UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 LTN1 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD CHST3 CSPG5 DCN NCAN BGN VCAN BCAN NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA5 SEM1 UBE2M PSMA6 FBXW11 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 MAP3K14 NFKB2 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 CHUK CUL1 PSMD12 PSMD11 UBB PSMD14 RELB PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PSMD3 PSMB1 PSMD1 UBA3 SKP1 ADRM1 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair H2BC12L UBE2N RAD51B RAD51C RAD9B RAD9A LIG1 UBE2V2 EXO1 CLSPN H4C9 TOPBP1 RFC5 RFC3 RFC4 RFC2 RBBP8 H2AX RAD50 FEN1 BRCC3 BABAM1 BABAM2 UIMC1 ABRAXAS1 RNF8 POLQ UBA52 RNF4 UBB NSD2 POLK UBC POLE H2BC9 RFC1 H2BC8 PARP2 H2BC5 MUS81 H2BC3 BRCA2 RPS27A LIG3 RAD51AP1 H2BC1 SLX4 EME1 EME2 FIRRM FIGNL1 GEN1 SLX1B XRCC2 XRCC3 PALB2 SPIDR POLD3 POLD4 POLD2 TP53BP1 XRCC1 SEM1 POLE4 PIAS4 ERCC4 POLE2 RNF168 ERCC1 UBE2I POLE3 MDC1 RTEL1 RAD52 KAT5 CHEK1 HUS1 SUMO2 POLD1 ABL1 DNA2 RHNO1 ATRIP BARD1 SIRT6 RAD17 ATM ATR BRCA1 H2BC26 RAD51 H2BC21 HERC2 RMI2 RMI1 PPP4R2 TOP3A TIPIN TIMELESS PPP4C RAD51D H2BC17 PCNA WRN H2BC12 H2BC13 PARP1 H2BC14 H2BC15 RPA1 H2BC11 RPA2 RPA3 RAD1 CDK2 CCNA2 MRE11 CCNA1 H3-4 NBN BRIP1 BLM POLH GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism GALM PGM1 GALE GALT AKR1B1 GALK1 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism QDPR ASRGL1 PCBD1 IL4I1 PAH KYAT1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways AKT1 YWHAQ CAV1 YWHAZ YWHAH PDPK1 YWHAE YWHAG YWHAB AKT2 AKT3 SFN INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases NHERF4 GUCY2C DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP MBD4 H2BC14 SMUG1 H2BC15 NEIL2 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 H2BC1 TDG H2AX H2AC19 NTHL1 H2BC26 NEIL3 H2AB1 H2AZ2 NEIL1 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME SLC28A2 ITPA SLC29A1 NME2 SLC29A3 ADA ADK NT5C2 SLC28A3 PNP NME1 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport ESYT2 CPTP CLN3 PLEKHA8 ARF1 GLTP ESYT1 ESYT3 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment IKBKB UBB RIPK3 IKBKG UBC UBE2N RPS27A UBE2D3 TICAM1 UBE2V1 RIPK1 UBA52 CHUK UBE2D2 UBE2D1 BIRC2 TLR3 BIRC3 TRAF6 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion PPIA ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 FRS2 FRS3 NRAS NTRK2 BDNF SOS1 HRAS PTPN11 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 TLR10 RPS6KA1 MAP3K8 MAP2K3 MEF2A PGLYRP4 MAP2K4 PGLYRP3 MEF2C HK3 MAPKAPK3 DEFB105B PGLYRP2 MAPK9 LEAP2 MAPK8 DEFB1 MAP2K7 S100A1 MAPK10 CLU TNIP2 HTN1 DEFB109B HTN3 S100A7A BPIFA1 GNLY BPIFA2 EPPIN PDXK CCR6 PGLYRP1 ATP7A NFASC PRSS3 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 SLC11A1 NOS3 DEFB116 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 PCBP2 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 CALM3 CALM2 DEFB4B S100A8 TLR2 S100A7 CD33 LTF DEFB103B REG3A CAP1 DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ZBP1 ITLN1 DEFB124 DEFB123 REG3G DEFB121 VCL DEFB107B ART1 PDZD11 DDX3X RNASE8 RNASE7 LRRFIP1 PI3 DEFA1B IQGAP1 DYNLT1 CHGA DEFB104B DEFA6 DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CYB5R3 ATOX1 CD4 BPIFB2 BPIFB1 BIN2 BPIFB4 BPIFB6 SEMG1 LCN2 PSMD12 CEACAM6 PSMD11 CEACAM8 PSMD14 PSMD13 PSMA7 PSMB6 PSMD8 ECSIT UBE2D3 PSMB7 PSMB4 PSMD6 PSMB5 HSPA1B PSMD7 PSMB2 CLEC5A PSMB3 PSMD2 PSMD3 VTN PGAM1 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 UNC93B1 PSMC3 ITGAX PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 C4B_2 CTNNB1 TREX1 NLRC3 IFI16 NLRP4 PRKCD FABP5 CD300A MAPKAPK2 ITGAL SERPINB1 HSPA8 KPNB1 MAPK14 MAPK11 HSPA1A DTX4 PRKACG PRKACB PTPN4 LGALS3 NDUFC2 ITCH YES1 HRAS NRAS CFD C3 GZMM CFB CAT RETN COLEC11 HSP90B1 AHCYL1 ARSA XRCC6 XRCC5 PRKDC APEH CTSA WASL DDX41 ACAA1 HEXB GLB1 GUSB ARSB CHUK UBA7 TBC1D10C UBE2L6 ISG15 IFIH1 HERC5 IKBKB TRIM25 RAB31 IKBKG RIGI CR1 AP2A2 DNM1 DNM2 DNM3 TRAPPC1 PPP2R5D PPP2CA PPP2CB PPP2R1B RAB27A GDI2 PLAC8 RAB10 RAB18 PIK3R2 PIK3CB PIK3R1 PLCG2 PIK3CA PTPN6 PROS1 CD177 FGB FGA FGG F2 DBNL GSN SERPING1 ALOX5 KNG1 CRCP POLR3GL F12 POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K UBE2D1 RELA ASAH1 MUC12 NFKB1 MUC15 AOC1 MUCL1 MUC3A MUC5AC MUC3B AGL CFP TBK1 MUC1 MME MUC2 MUC7 MUC4 MUC6 MUC16 B2M MUC17 GOLGA7 MUC19 GYG1 MUC5B MUC20 MUC21 HLA-H HLA-B DNAJC3 HLA-C FPR2 ITPR1 ITPR2 HLA-E PLAUR ITPR3 SERPINB6 PLAU HRG PIK3R4 PSAP PAFAH1B2 ATP8A1 PTPRJ ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0E1 ATP6V1G2 GM2A PTAFR ATP11B OTUD5 ATP11A IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 FCN1 MAGT1 FCN2 ATP6V0D1 IFNA8 FCN3 RAF1 CRP TRIM4 ATP6V0D2 COLEC10 ATP6V1A IKBKE TOMM70 RIPK2 ATP6V0A2 ANO6 ATP6V0A4 PFKL IMPDH1 IMPDH2 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 ATP8B4 SIKE1 TLR8 TLR7 RNF135 TCIRG1 ATP6V0B IFNB1 ATP6V1B2 STING1 ATP6V0C ATP6V1B1 MGST1 MAPK13 MAP3K7 IFNA14 IFNA16 LAT2 IFNA17 ATP6V0E2 ATP6V1G3 UBE2V1 MASP1 IFNA10 AAMP VCP GLIPR1 IGHG3 TKFC IGHG4 IRAK1 IRAK2 IGHG1 IGHG2 CD3G NLRP3 IFNA21 FCGR3A MANBA SYK NME2 FGR HCK MAVS FPR1 FYN AMPD3 FCGR1A UBE2N FCGR2A TAB3 TAB2 TAB1 ALPK1 NLRX1 AGER HSP90AB1 S100A12 ALDOC N4BP1 PRKCSH MYD88 CD81 ALDOA CPB2 NFKBIB MBL2 HMGB1 CFH NKIRAS1 C5AR2 PDPK1 NKIRAS2 C5AR1 IKBIP CFI C2 DDOST IRAK4 C5 IRF3 TLR9 C6 PELI1 C7 LRRC14 TRAF3 C9 TRAF6 USP14 PELI3 C8B IRF7 PELI2 PIK3C3 C8A C8G NLRC5 CR2 USP18 TIFA CD46 MAP3K1 C1QB C1R S100B CPN2 SAA1 CPN1 NOD1 CD59 NOD2 CD55 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 PTPN11 C1QC PKM FTH1 GPR84 ALDH3B1 VAMP8 CALM1 FTL RAB5C CHRNB4 TREM2 KLRK1 MAN2B1 GRAP2 KLRC2 TYROBP KLRD1 LCP2 TXNDC5 AP1M1 SLC2A3 IGF2R NAPRT CTSZ ANPEP ATP6AP2 SOCS1 PPP3R1 CCT2 ADGRE5 ADGRE3 APP NLRC4 MEFV NFKB2 PANX1 PPP3CA P2RX7 PPP3CB PYCARD PSTPIP1 AIM2 CASP1 TXNIP CNPY3 NLRP1 SIGIRR SUGT1 IRAK3 MLEC CCT8 RAP1B B4GALT1 PTPRC EEF1A1 EEF2 GMFG MCEMP1 RNF216 MAPK12 FUCA2 OLR1 RAB6A JUN YPEL5 TOM1 ARL8A NIT2 MAPK7 KIR3DS1 ACP3 SNAP29 TRIM21 RAC1 RNASET2 TMBIM1 TRIM56 CANT1 RHOA ELMO1 ELMO2 DOCK1 ATG7 CRK C6orf120 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 NBEAL2 FCER1A HUWE1 FCER1G RAP2C RAP2B TAX1BP1 VNN1 CAB39 GCA HBB SRP14 ENPP4 IRAG2 ADGRG3 GGH ADA2 CXCL1 MS4A3 TNFAIP6 CHI3L1 MS4A2 RBSN TEC PTX3 FRMPD3 CLEC10A TOLLIP AHSG PLEKHO2 GRN TMEM179B DOCK2 RAB3D CXCR1 CDC42 RAB44 LAMP1 LAMP2 CXCR2 KCMF1 UBR4 ILF2 RAB37 RAB4B FCAR FGL2 CAPZA1 RAB24 CPPED1 CAPZA2 PPBP MGAM CALML5 KRT1 TXK TRPM2 VAT1 ORM1 ORM2 CSTB CHIT1 SVIP QPCT COTL1 COPB1 UBA3 LPO CLEC12A UBE2K UBE2M NOS2 ATP6V1H TMEM30A RAB7A SCAMP1 RNASE2 TICAM2 FLG2 LY96 CNN2 CFL1 AZU1 HRNR TRAF2 TICAM1 PIGR CASP8 TMC6 PAK2 SERPINB10 SERPINB12 RIPK1 CD14 ANXA2 FADD TLR4 LRG1 UBE2D2 MIF IGHV3-23 HP OLFM4 IGLV IGLV2-8 IGKV1-16 PTPRB IGKV1-17 FCGR3B IGKV1-12 IGHV3-7 IGHV3-9 PRCP V2-11 IGHV3-30 V3-4 VPS35L V3-3 V2-17 DHX58 V3-2 IGHV3-33 V2-15 DHX36 IGKV1D-39 SURF4 V2-19 PRG2 IGKV1D-33 PRG3 ITK CDC34 CYSTM1 QSOX1 IGKV2D-28 CD53 IGKV4-1 IGHV7-81 CD63 PRKCQ PGRMC1 CARD11 CREG1 V1-11 CD58 IGKV2D-30 CD68 V1-16 V1-13 MPO IGHV4-59 IGHV1-69 OSTF1 CD93 BCL10 ATAD3B RASGRP2 RASGRP1 DOK3 RASGRP4 IGLV2-11 TRIM32 IGLV1-40 TARM1 IGLV1-47 IGLV6-57 IGLV2-14 MVP IGLV1-44 IGKV3-15 IGKV3-11 LYN PDAP1 DUSP4 V2-8 S100P DUSP3 RIPK3 V1-20 ABCA13 VRK3 IGKV2D-40 IGHV3-11 DUSP6 NHLRC3 IGHV3-13 DUSP7 UNC13D IGKV1D-16 RNF125 A1BG IGLV7-43 IGKV1D-12 CRACR2A PRDX4 NFKBIA MYH9 S100A11 GSDME IGLV1-51 ATF2 IGLV2-23 KIR2DS4 IGKV3-20 KIR2DS5 PA2G4 IGHV4-34 IGHV1-2 SERPINA3 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 SERPINB3 NFAM1 V1-9 V5-4 TMT1A AGA V1-7 V5-1 CARD9 ERP44 V1-5 SLCO4C1 V1-3 GHDC IGKV3D-20 DNAJC5 V5-6 IGHE EPX IGLV3-19 CLEC4A CLEC4C IGKV2-30 CLEC4D IGHV2-70 CLEC4E IGHV2-5 IGLV3-1 BRI3 IGHV3-48 HVCN1 MALT1 CLEC7A IGLV3-25 IGLV3-27 CLEC6A IGKC PRKCE IGKV1-39 PLPP5 IGLV3-21 PLPP4 MYO5A IGKV1-33 KCNAB2 V4-6 MYH2 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 MNDA V4-1 FOLR3 IGKV5-2 CDK13 IGKV1-5 SIGLEC16 IGLC6 SIGLEC15 PTPRN2 SIGLEC14 STK11IP CEACAM3 DNASE1L1 DPP7 DNAJC13 CASP10 CRISP3 HEBP2 CMTM6 FOS MAP2K1 PKP1 RAP1A MAPK1 SLC15A4 SLC2A5 MAPK3 DSC1 ICAM2 SOS1 ACTR1B CTSH LAMTOR2 APOB LAMTOR1 CTSC LAMTOR3 RELB MRE11 ACTR10 ITGB2 GSDMD CASP9 MAP2K6 ATG12 NOS1 ATG5 PIN1 LTA4H CASP2 LGMN HSPA6 APAF1 CEACAM1 FRK C3AR1 IL18 IL1B TLR3 PADI2 MAP3K14 TNFRSF1B GSTP1 IST1 ACLY SLC27A2 LRRC7 HPSE PPIA ARG1 TP53 SNAP25 ALAD PGM2 CPNE1 CPNE3 PGM1 DGAT1 ROCK1 CSNK2B MUC13 DSP PLD4 PLA2G6 PLD1 CKAP4 PLD3 PLD2 DSG1 SLC44A2 LPCAT1 LBP CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 NEU1 WIPF3 AGPAT2 DYNC1LI1 BST1 IQGAP2 PRDX6 PLA2G2A NCKAP1L JUP ITGAV ARHGAP9 ARPC1B ARPC1A GAA APRT PECAM1 PLCG1 PPP2R1A ORMDL3 BTRC PRKACA CEP290 SKP1 HSP90AA1 FBXW11 TUBB DYNLL1 ABI2 NFATC3 UBA52 ABI1 OPTN P2RX1 CUL1 UBB NCF1 NCF2 UBC NCF4 STK10 RPS27A DYNC1H1 TUBB4B DEGS1 BCL2 BCL2L1 ARPC4 ARPC5 ARPC2 ARPC3 NPC2 NF2 CAPN1 PRSS2 SNAP23 BRK1 ADAM10 NCK1 ACTR3 COMMD9 ACTR2 ADAM8 COMMD3 PSEN1 LCK GALNS NCSTN A2M ELANE GLA CDA CTSV CTSS CAND1 ARMC8 WASF1 MMP25 WASF2 WASF3 CTSL CASP3 CTSK TIMP2 BAIAP2 CTSG GNS CTSD CTSB HMOX1 MMP8 BTK MMP9 HMOX2 ICAM3 TCN1 CD44 DSN1 KIR2DS2 GPI PYGB PTK2 PYGL FAF2 SIGLEC9 NCR2 C1QBP STBD1 RAC2 RAB3A KLKB1 SPTAN1 LILRA3 VAV3 H2AC19 RHOG RHOF ACTB LAIR1 VAV1 H2AC14 VAV2 H2BC12L LILRB2 LILRB3 SIGLEC5 OSCAR WAS CD300E CD19 PAK1 CD300LB GAB2 CREBBP PAK3 H4C9 SELL MYO9B TREM1 H2AC20 RAB9B CASP5 CASP4 SDCBP H2AX ACTG1 CD36 CST3 H3-3B H2AZ1 H3C8 CYBB CYBA TSPAN14 ARHGAP45 C1S NCKIPSD TTR C4A H3C15 DHX9 BST2 CD209 H2BC9 RAB14 H2BC8 VAPA H2BC5 CD47 H2BC3 DIAPH1 H2BC1 SIRPA PNP PPIE SIRPB1 H2AB1 EP300 H2AC8 H2AC6 H2AC7 CD180 MOSPD2 LY86 ITGAM EEA1 TASL IRF5 TXN STOM DERA LIMK1 ABL1 RAB5B TIRAP STAT6 H2BC26 NFATC2 NFATC1 H2BC21 PTGES2 TLR6 TLR5 C1QA H2BC17 TNFAIP3 H2BC12 H2BC13 H2BC14 H2BC15 POLR1C H2BC11 CYLD POLR1D BIRC2 BIRC3 CGAS HGSNAT SERPINA1 IDH1 C4BPA C4BPB POLR2E POLR2F POLR2H TANK POLR2K POLR2L FUCA1 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism PNPLA6 PNPLA7 GDE1 GDPD1 GDPD3 ENPP6 GDPD5 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs NEIL3 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism NHLRC1 IDUA GNS HYAL1 SGSH RPIA GLB1 SLC37A4 IDS ALDOB G6PC1 GUSB ARSB UBA52 G6PC3 KHK GBE1 NAGLU GAA UBB SI GYG2 DCXR TALDO1 GYG1 LCT UBC HGSNAT RPS27A GALNS PPP1R3C GYS2 EPM2A GYS1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions DNM1 DNM2 DAB2 GJA1 CLTCL1 CLTC CLTB CLTA SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 VEGFA VEGFB VEGFC FLT4 VEGFD KDR PGF GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism ARSF ARSG SUMF2 ARSD SUMF1 HEXB CTSA HEXA GLB1L3 GBA1 GLB1L2 GLB1L ENPP7 GM2A GLB1 ARSB STS ARSA SMPD3 NEU2 GALC SMPD2 NEU3 SMPD4 GBA3 NEU1 M6PR SMPD1 GLA GBA2 ARSL ARSJ ASAH1 ARSK PSAP ASAH2 ARSH ARSI NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPL24 EIF4A3 RPL27 CASC3 RPL26 MAGOH RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A RBM8A UPF3B MAGOHB RNPS1 PPP2R2A PPP2R1A RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 NCBP1 RPL27A NCBP2 RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF1 PNRC2 RPL37A GSPT2 GSPT1 UPF3A RPL36A UPF2 ETF1 RPL35A PABPC1 RPL22L1 RPS27L PPP2CA DCP1A EIF4G1 RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 EP300 PSMA5 PSEN2 SEM1 PSMA6 PSMA3 PSMC5 TACC3 PSMA4 APH1A APH1B PSMC6 ACTA2 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ADAM10 CREBBP PSENEN AKT1 YWHAZ MAML2 PSEN1 MAML1 NCSTN DLL4 MAML3 NOTCH2 NOTCH4 SKP1 HEY1 HEY2 SNW1 MAMLD1 RBX1 KAT2B KAT2A UBA52 FLT4 CUL1 PSMD12 PSMD11 UBB NOTCH1 PSMD14 SMAD3 PSMD13 UBC RBPJ PSMA7 PSMB6 RPS27A HES5 PSMD8 JAG1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES1 ADRM1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP MBD4 H2BC14 SMUG1 H2BC15 NEIL2 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 H2BC1 TDG H2AX H2AC19 NTHL1 H2BC26 NEIL3 H2AB1 H2AZ2 NEIL1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A EIF2S3 EIF4A2 EIF4A1 EIF2S2 RPL10 EIF2S1 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 EIF4E EIF4B RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A PABPC1 EIF1AX RPL22L1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF4G1 RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage IL1B GSDMD CASP3 CASP5 IL18 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling ARRB1 TGFBR3 TGFB2 GIPC1 TGFBR1 TGFBR2 ARRB2 TGFB1 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I VWF ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism FADS1 ACAA1 ELOVL1 ACOT8 ELOVL5 ELOVL2 HSD17B4 FADS2 ELOVL3 ACSL1 SCP2 ABCD1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN DLL4 PSEN2 APH1A NOTCH4 APH1B YWHAZ PSEN1 ADAM10 NCSTN JAG1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling STAT3 ELOB LYN SYK ELOC JAK2 HCK STAT1 CSF3 UBA52 UBE2D2 RNF7 CUL5 SOCS3 CSF3R JAK1 UBB UBC TYK2 RPS27A UBE2D3 STAT5A SOCS1 UBE2D1 STAT5B SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS1 PIK3R2 PIK3CB NRAS PIK3R1 THEM4 IRS4 FRS2 PIK3CA FGF1 FGF4 FLT3LG FGF16 FGF9 PDPK1 FGF18 FGF20 SOS1 FGF23 TLR9 FLT3 AKT2 GAB2 FGF6 FGF2 PIK3C3 KLB GAB1 IGF2 FGF19 IGF1 FGFR4 TRIB3 PTPN11 IRS2 FGF7 PDE3B IGF1R FGF22 FGF3 FGF10 PIK3R4 HRAS CILP REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins F2 PROC BGLAP F7 PROS1 FURIN F9 GAS6 PROZ F10 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors RBFOX1 PPARG MEF2C GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism EXT2 HS2ST1 B3GNT7 CHST11 CHST12 CHST15 B3GNT4 FAM20B B3GNT3 B3GNT2 CHST13 CHST14 SPAM1 SLC26A11 CSGALNACT1 CSGALNACT2 CHSY1 KERA CHSY3 SLC26A2 LUM SLC26A1 LYVE1 HMMR UXS1 CHST6 CHST7 HS3ST3A1 B4GALT2 B4GALT3 CHPF2 CHST1 SGSH CHST5 CHST2 CHST3 FMOD CHPF HYAL2 NAGLU CHP1 ABCC5 CEMIP PXYLP1 B4GALT6 SLC35B3 B4GALT7 SLC35B2 B4GALT4 B4GALT5 HS6ST1 SDC4 HS6ST2 PRELP HS6ST3 SDC2 SDC3 B3GAT3 B3GAT2 ST3GAL4 B3GAT1 ST3GAL1 ST3GAL2 ST3GAL3 IDUA HEXB NCAN HEXA BGN GLB1L3 GLB1L2 VCAN GLB1L SDC1 HYAL1 GLB1 SLC35D2 HYAL3 EXTL2 HYAL4 HAS1 IDS CSPG5 GUSB ARSB HAS3 HAS2 OGN EXTL3 HSPG2 HPSE BCAN B4GALT1 HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 GALNS HS3ST3B1 HPSE2 XYLT2 XYLT1 ST3GAL6 GPC1 SLC9A1 CTSL GPC3 DSEL GPC2 GPC5 GNS GPC4 GPC6 B3GALT6 UST DCN AGRN DSE CD44 OMD ACAN NDST2 NDST1 NDST4 B4GAT1 NDST3 STAB2 GLCE PAPSS2 PAPSS1 SLC17A5 EXT1 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 UBB ABL2 PTPRJ UBC RPS27A SOCS6 SLA2 FLT3LG SOCS2 UBA52 CSK SH2B3 FLT3 CBL SLA POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair POLB PARP1 APEX1 ADPRS LIG1 PARP2 FEN1 PARG REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity CBFB RUNX1 CCND3 CCND2 PTPN11 SRC TNRC6C MOV10 AGO3 AGO4 AGO1 PML AGO2 TNRC6A TNRC6B CDK6 CCND1 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair POLE4 RFC5 RFC3 RFC4 RFC2 POLE2 POLE RFC1 POLE3 PCNA POLB APEX1 LIG1 RPA1 RPA2 POLD3 POLD1 FEN1 POLD4 POLD2 RPA3 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex EP300 LTBP4 ARHGEF18 LTBP2 LTBP3 MEN1 LTBP1 TGFB2 TGFB3 MYC PRKCZ CCNK CCNT2 BAMBI CCNT1 ITGB3 PPP1CC SKIL ITGB5 SP1 TGIF1 ITGB8 PMEPA1 ITGAV TGIF2 ITGB6 TGFB1 XPO1 SERPINE1 UCHL5 JUNB NEDD4L RNF111 TGFBR3 STRAP PPP1R15A CDK8 USP15 NEDD8 RBL1 PPP1CB TFDP1 TFDP2 COL1A2 E2F4 PARD6A CDK9 UBE2D1 PPM1A SNW1 UBE2M E2F5 TGFBR1 USP9X TGFBR2 RHOA MTMR4 MAPK1 NCOR2 PARP1 MAPK3 STUB1 ITGB1 UBA52 NCOR1 TRIM33 CBL CDKN2B ATP1B4 SKI SMAD2 UBB FURIN SMAD4 SMAD3 HDAC1 SMURF2 UBC SMURF1 SMAD7 RPS27A UBE2D3 YBX1 WWTR1 CGN F11R FKBP1A PARD3 PPP1CA CCNC ITGA8 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis IDI1 ACAT2 IDI2 MVD PMVK MVK GGPS1 HMGCS1 PLPP6 LSS FDFT1 SQLE FDPS KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs ALK BCL11A PRKAR1A HIP1 EML4 NPM1 CLTC PPM1B EIF2AK3 STRN BIRC6 FN1 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA NUP214 PRKCD PRKCA TNFSF13 SET ANP32A ELAVL1 XPO1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse RHOB MYL6 ERBB2 MYL9 SEMA4D MYH9 RHOA ROCK2 PLXNB1 RND1 ARHGEF11 LIMK2 ROCK1 LIMK1 ARHGEF12 MYH14 MYH11 RHOC MYL12B MYH10 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 C3 C2 C5 C4A CFB C4B_2 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells HGS UBB MET STAM CTNND1 UBC CBLL1 EPS15 STAM2 RPS27A CTNNB1 CDH1 SRC SH3KBP1 SH3GL2 UBA52 SH3GL3 CBL SH3GL1 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism PDK1 PDHX DLAT PDK4 DLD PDP1 MKLN1 PDP2 LDHA GSTZ1 PDHB UBA52 ME1 MAEA GID4 GID8 RANBP9 UBB UBC NEK1 RPS27A PDHA2 PDHA1 PDPR WDR26 RMND5B RMND5A PDK3 SIRT4 ARMC8 PDK2 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane CCT2 TCP1 CCT8 CCT5 CCT4 HDAC6 CYS1 LZTFL1 UNC119B ARL6 ARL3 ARL13B MCHR1 RAB8A NPHP3 RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 ARF4 PKD2 PKD1 CNGA2 BBS9 CNGA4 BBS7 SMO BBS5 BBS4 MKKS EXOC8 EXOC7 SSTR3 BBS10 RP2 BBS12 EXOC4 EXOC3 EXOC6 INPP5E EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 PDE6D RHO GBF1 RAB11A ATAT1 TTC8 CCT3 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions CBFB RUNX1 CLDN5 OCLN TJP1 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance APOB APOE LIPC LDLRAP1 LDLR PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import ACOT2 ACAA1 ACOT4 ACOX2 ACOX3 PEX26 CROT DDO CAT EPHX2 HSD17B4 PEX2 PECR BAAT IDE PEX10 PEX12 UBE2D1 PIPOX PEX13 GNPAT AGXT PEX14 NUDT7 ECH1 NOS2 PAOX AGPS HACL1 USP9X HMGCL ZFAND6 MPV17 PEX1 LONP2 PEX7 PEX6 UBA52 UBE2D2 PHYH ACOX1 TYSND1 HAO1 HAO2 CRAT UBB UBC EHHADH NUDT19 RPS27A UBE2D3 SCP2 IDH1 GSTK1 ACOT8 DECR2 SLC27A2 DHRS4 AMACR DAO TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT10 TP53 TNKS1BP1 CNOT4 CNOT6 RGCC CNOT6L CNOT7 PLK2 CNOT1 CNOT11 PLK3 CNOT2 CNOT3 PLAGL1 CDC25C CNOT8 CNOT9 NPM1 BTG2 CPAP TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) SV2C SV2B SV2A VAMP1 VAMP2 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP1 VAMP2 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation AP2S1 ATP6V1H ARF1 CD4 LCK AP2A1 AP2B1 AP2A2 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 STAT3 HGF MET BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs ALOX15 ALOX12 ALOX5 PTGS2 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation CALM1 GCHFR AKT1 PRKG2 PTS NOS3 SPR GCH1 DHFR HSP90AA1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes H2AC14 H2BC21 H3-3B H2BC12L H3C8 SMC4 H2AC8 SMC2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 NCAPH2 NCAPG2 H4C9 H3C15 NCAPD3 CCNB1 MCPH1 H2BC9 H2BC8 H2BC5 H3-4 SET KMT5A H2BC3 H2AC20 H2BC1 H2AX RB1 PLK1 H2AC19 CDK1 H2BC26 H2AB1 H2AZ2 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis PSMA5 SEM1 PSMA6 PSMA3 SYVN1 DERL2 PSMC5 PSMA4 PSMC6 IHH OS9 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ADAM17 DISP2 SCUBE2 NOTUM SEL1L SHH GPC5 HHAT ERLEC1 UBA52 P4HB PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 VCP DHH PSMB1 PSMD1 ADRM1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant ADAM17 DLL4 NOTCH1 DLL1 ADAM10 JAG2 JAG1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis RFC5 RFC3 RFC4 RFC2 PRIM2 RFC1 PRIM1 POLA1 POLA2 PCNA LIG1 RPA1 RPA2 POLD3 POLD1 FEN1 POLD4 POLD2 DNA2 RPA3 SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes MCM3AP DPF1 DPF2 DPF3 BCL6 SMARCC1 SMARCC2 CCNK CCNT2 CCNT1 PAXIP1 SUPT16H TCF3 CTNNBL1 GTF2F1 GTF2F2 EXO1 REV1 CREBBP MAD2L2 REV3L RFC5 SUPT4H1 SS18L1 RFC3 RFC4 SMARCA2 RFC2 SMARCA4 CTR9 RTF1 PAF1 ELOA2 E2F7 SUPT5H E2F8 CDK9 ASH2L RELA TAF4B ELL TAF7L ELOA NELFB ELOB NELFCD NELFA SS18 NFKB1 ELOC NCOA6 PAX5 NELFE ACTL6A MSH6 JUND EXOSC10 UBA52 E2F2 C1D MPHOSPH6 AICDA CTDP1 FOSB TAF9 TAF1L POLR2A UBB POLR2B POLR2C POLR2D UBC RFC1 POLR2G POLR2I RPS27A TAF9B POLR2J TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 POLD3 TAF7 TCEA1 POLD2 TAF6 TAF5 STAT3 TAF4 TAF3 TAF2 TAF1 NFKB2 KMT2D KMT2C DIS3 MAFK SKIC8 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 MEF2B EXOSC8 STAT6 EXOSC3 DPY30 EXOSC2 EXOSC1 PAGR1 BCL7A MYB BCL7C BCL7B BATF WDR5 E2F5 KDM6A TBP ARID1A PCNA ARID1B PMS2 BACH2 HOXC4 MLH1 EAF1 EAF2 CDC73 CEBPA SMARCD1 SMARCD2 SMARCD3 RELB LEO1 APEX2 RBBP5 SUPT6H ZBTB17 MSH2 POLR2E AFF4 POLR2F POLI POLR2H SMARCB1 POLH IRF8 POLR2K POLR2L MLLT1 MLLT3 SMARCE1 ACTB IWS1 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis UBB NHLRC1 GYG2 GYG1 UBC RPS27A PGM1 PPP1R3C EPM2A GYS2 UBA52 GYS1 UGP2 GBE1 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 BANF1 NUP50 KPNA1 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 SLC25A4 RAE1 RANBP2 NUP155 SLC25A5 HMGA1 NUP153 PSIP1 SLC25A6 NUP35 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis H2AC14 EP300 STAT3 H2BC12L H2AC8 H2AC6 H2AC7 MYC SPI1 KMT2A RXRA RARA CSF3R CBFB H4C9 RUNX1 FLI1 H2AC20 TFDP1 TFDP2 KLF5 H2AX CEBPB CDKN1A E2F1 H2BC26 H2BC21 MYB H3-3B H3C8 TAL1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 GATA2 CEBPA H3C15 CDK4 CDK2 LEF1 H2BC9 H2BC8 H2BC5 CEBPE H2BC3 GFI1 H2BC1 IL6R H2AC19 H2AB1 H2AZ2 DEK NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking DNM2 NOS3 CAV1 WASL NOSTRIN KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation LUM OMD HEXB ACAN GNS HEXA GLB1L3 GLB1L2 GALNS GLB1L GLB1 PRELP FMOD OGN KERA EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle CXCR4 CCR5 XRCC6 XRCC4 XRCC5 HMGA1 BANF1 KPNA1 PSIP1 LIG1 LIG4 CD4 FEN1 PPIA CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle EDEM3 EDEM1 AMFR SYVN1 DERL2 RNF5 EDEM2 RNF103 RNF139 OS9 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 PRKCSH UBA52 MAN1B1 UBB PDIA3 UBC GANAB CALR RPS27A SEL1L CANX REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense CASP1 PIM1 GBP1 SFN CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism CYP4A22 PTGR1 PTGR2 GGT1 CYP2C19 CYP4F11 ALOX5AP CYP2U1 DPEP2 DPEP1 CYP4A11 PTGS2 PTGS1 GPX2 LTA4H GPX1 GPX4 ALOX12B CYP4F2 TBXAS1 GGT5 CYP4F3 CYP4F8 PRXL2B CBR1 CYP1A1 CYP2C9 CYP2C8 EPHX2 ALOX5 MAPKAPK2 CYP1A2 HPGDS FAAH CYP8B1 PTGDS PTGES2 PTGES3 FAAH2 AWAT1 CYP4B1 PTGES ABCC1 ALOXE3 PTGIS ALOX15 ALOX12 SLC27A1 CYP1B1 CYP2J2 ALOX15B PLA2G4A PON3 HPGD AKR1C3 PON2 PON1 LTC4S CYP4F22 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors CALCR ADM2 RAMP2 RAMP1 CALCRL RAMP3 ADM CALCA IAPP CALCB REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions FBN1 ITGAE COL16A1 ITGAX ITGA3 ITGAD ITGA7 ITGAM CDH1 BSG ITGB3 ITGA9 ITGB5 ITGB8 FGB ITGAV FGA COL23A1 ITGB6 FGG HSPG2 ITGA1 LUM PECAM1 COL13A1 ITGB7 ITGAL COL9A1 COL9A3 COL9A2 COL18A1 ITGA4 ITGA5 FN1 COL4A2 COL4A1 COL4A4 ICAM2 COL4A3 AGRN ITGB1 ICAM3 ICAM1 ICAM4 ICAM5 ITGA6 KDR CD44 ITGA2 SPP1 ITGA10 CD47 JAM2 ITGA2B JAM3 TNC COMP VCAM1 ITGB2 IBSP F11R VTN THBS1 ITGA8 ITGA11 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 CRP V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 C1QB IGHV2-5 C1R IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 C1QC IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1QA C1S IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGHG3 IGHG4 IGLV2-11 IGLV1-40 IGHG1 IGLV1-47 IGLV6-57 IGHG2 IGLV2-14 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO SENP5 SENP1 SUMO1 SENP2 SUMO3 SUMO2 UBA2 UBE2I SAE1 RWDD3 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters CALM1 SLC8A1 SLC9A1 CP SLC8A2 SLC30A3 SLC24A5 SLC24A1 SLC30A2 SLC24A4 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC24A2 SLC39A7 SLC24A3 SLC39A2 SLC11A2 SLC39A1 SLC8B1 SLC39A3 SLC30A8 SLC9A2 SLC9A3 SLC39A4 SLC30A5 SLC9A4 SLC9A5 SLC30A10 SLC9A6 SLC40A1 SLC9A7 SLC11A1 SLC9A8 HEPH SLC9A9 SLC31A1 SLC41A2 SLC41A1 SLC8A3 SRI RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter TBP BDP1 POLR1C POLR1D CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H GTF3C1 POLR3K GTF3C2 POLR2H GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR2K POLR2L BRF1 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNG3 GNB4 BTK GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion APOBEC1 APOBEC2 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC3C CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle CDT1 CDC6 JAK2 PIF1 KIF23 SHQ1 RAD51C KIF2A KIF2C FOXM1 KIF2B UBE2V2 CABLES1 CENPE WEE1 VRK1 LEMD2 CTDNEP1 CNEP1R1 LMNB1 PSMD12 PSMD11 PSMD14 PSMD13 FBXL18 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 LYN PSMA3 PSMC5 GOLGA2 PSMA4 PSMC6 CDC25A CDC25B PSMC3 PRIM2 PSMA1 PRIM1 PSMA2 PSMC4 POLA1 PSMC1 POLA2 MDC1 PSMC2 KAT5 CHEK2 MAX CHEK1 DAXX HUS1 YWHAB DNA2 RHNO1 XPO1 AKT1 TNPO1 NUP214 PCBP4 PRKCA YWHAZ ATRIP BARD1 SET PLK3 TPX2 RAD17 ATM ATR CDKN1A KPNB1 MAPK14 BRCA1 MAPK11 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 RMI2 MCM4 MCM5 E2F5 NEK11 MCM6 RMI1 MCM2 E2F6 TOP3A RBX1 PCNA WRN MAPK1 NPM1 RPA1 RPA2 MLH1 RPA3 RAD1 CSNK1A1 BUB1B CDC20 FBXO5 CCNA2 MRE11 CCNA1 BUB3 MAD2L1 NBN KMT5A CDC25C BLM CCND3 CCND2 ACD TINF2 ATRX TERF1 NUP107 TERF2 POT1 MDM2 NUP188 TERF2IP MDM4 RCC1 RAD9B BANF1 RAD9A LIG1 NUP210 MYBL2 NUP93 EXO1 CHMP4C DHFR CHMP4B CHMP4A NUP205 TOPBP1 POM121 ZNF385A RFC5 RFC3 RFC4 AAAS RFC2 HJURP NUP160 POM121C RSF1 RBL2 NUP85 MIS18BP1 RBL1 OIP5 TPR BIRC5 NUP88 CENPW MIS18A NUP155 AURKB RBBP8 E2F4 NUP153 CDC7 CHMP2B CHMP2A RAD50 FEN1 NUP62 NDC1 SEC13 NUP133 CDC14A RANGAP1 NUP50 CHMP3 NUP54 CHMP6 CHMP7 CDKN2B VPS4A POLR2A POLR2B NSD2 NUP42 POLR2C POLR2D POLR2G NUP43 POLR2I PRDM9 POLR2J RAE1 RANBP2 TUBB8 SPAST RUVBL2 IST1 RUVBL1 TUBB8B CC2D1B NUP35 RAN RAB2A GORASP2 NUP37 PIAS4 BLZF1 SMC4 SMC2 NCAPG NCAPH UBE2I NCAPD2 DYRK1A CKS1B PPP2R3B SUMO1 PKMYT1 ARPP19 NCAPH2 NCAPG2 CDK6 NIPBL ENSA SIRT2 NCAPD3 TP53 MAU2 MASTL MCPH1 PPP2R2D DKC1 NHP2 CSNK2A1 GAR1 CSNK2A2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C CSNK2B PPP2CA PPP2CB RAD51 PPP2R1B PPP2R5E NOP10 LEMD3 RAB1A RAB1B ANKLE2 BRIP1 PRKCB DYNC1LI1 FKBP6 DYNC1LI2 ESCO1 ESCO2 CDCA8 MYC SKA1 SKA2 CDKN2D CDKN2C PTTG1 CCND1 CLSPN LPIN1 LPIN2 LPIN3 NUF2 EMD NUDC YWHAE CEP57 DYNLL2 CETN2 CEP164 CCP110 PPP1CB PPP2R2A INCENP ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 ANAPC15 SYCP2 BTRC PRKACA ANAPC16 CENPA SYCP1 UBE2D1 CEP290 SPO11 ANAPC10 NINL SYNE2 CENPC SYNE1 YWHAG ANAPC11 RAB8A SUN1 TEX12 FZR1 SKP1 CDK5RAP2 TEX15 CDC23 OFD1 SMC1B CDC26 MSH4 HSP90AA1 CDC27 MSH5 BORA CDCA5 CEP135 DMC1 ANAPC7 PPP1R12A PDS5B SYCE3 PSMC3IP FBXW11 PDS5A UBE2C CDKN2A WAPL TUBB SYCE2 CENPT CEP131 UBE2E1 ESPL1 SYCE1 HAUS4 MND1 CENPU HAUS3 HSPA2 REC8 CSNK1D UBE2S HAUS6 BRCC3 CDC16 MLH3 ANAPC4 HAUS5 STAG3 ANAPC5 SYCP3 CSNK1E BABAM1 SMC3 ANAPC1 BABAM2 TUBG1 DYNLL1 ANAPC2 UIMC1 RAD21 CKAP5 ABRAXAS1 CENPF TUBA4A RNF8 HAUS2 HAUS1 STAG1 CENPH AKAP9 STAG2 CEP63 CENPI SMC1A MAPRE1 SFI1 UBA52 TAOK1 AJUBA OPTN CENPK PAFAH1B1 CENPL CENPM SDCCAG8 DYNC1I2 CPAP AKT2 DCTN2 AKT3 CENPN SSNA1 DCTN3 CENPO CUL1 CENPP AURKA CENPQ CCNB2 CENPS CCNB1 UBB HAUS8 PRKAR2B HAUS7 UBC POLE CEP70 RFC1 CEP72 CEP192 PCNT RPS27A BRCA2 CEP76 CLASP1 CEP78 PLK4 OBI1 FIRRM LCMT1 DYNC1H1 FIGNL1 ODF2 PPME1 CEP152 CDK11A TICRR NDE1 CDK11B PLK1 TUBB4B CLIP1 TUBB4A NEDD1 ALMS1 MAD1L1 CDK1 POLD3 CEP41 CEP43 POLD4 POLD2 SFN POLE4 POLE2 POLE3 NDC80 RPS27 POLD1 SPDL1 RRM2 NSL1 LIN54 LIN37 KNL1 ZW10 LIN9 LIN52 DSN1 RCC2 ZWINT AHCTF1 TK1 RB1 CCNH NDEL1 H2AC19 H2AC14 H2BC12L UBE2N HSP90AB1 MIS12 PPP1CC YWHAQ YWHAH DYNC1I1 H4C9 SMARCA5 HMMR NEK9 H2AC20 NEK6 NEK7 B9D2 SPC24 SPC25 H2AX ERCC6L PHF20 ZWILCH DSCC1 CHTF18 CHTF8 H3-3B CTC1 KNTC1 LBR STN1 H3C8 TEN1 SGO1 SGO2 GTSE1 FKBPL TUBB6 TUBB3 TUBB1 PMF1 H2AJ E2F2 TUBA4B CCNE2 CCNE1 H3C15 NUMA1 TUBG2 MZT2B MZT2A NME7 TUBGCP2 H2BC9 MZT1 H2BC8 TUBGCP5 H2BC5 TUBGCP6 TUBGCP3 H2BC3 TUBGCP4 H2BC1 TUBA8 WRAP53 TUBA1C TUBA1B H2AB1 TP53BP1 EP300 SUN2 TOP2A TUBB2B PHLDA1 TUBB2A H2AC8 RNF168 H2AC6 H2AC7 ITGB3BP TUBAL3 RTEL1 TUBA3E TUBA3D CDKN1C TUBA3C SKP2 MCM10 DBF4 COP1 BUB1 RPA4 CLASP2 ABL1 CDK7 TFDP1 TYMS TFDP2 MNAT1 GSK3B E2F1 E2F3 H2BC26 H2BC21 CDKN1B HERC2 H2BC17 H2BC12 H2BC13 KIF20A H2BC14 H2BC15 H2BC11 FBXL7 PTK6 CDK4 TERT CDK2 HDAC1 H3-4 KIF18A RBBP4 CENPX PPP6C PPP6R3 POLR2E GORASP1 POLR2F EML4 POLR2H RBBP7 GMNN USO1 ORC5 POLR2K ORC4 POLR2L ORC6 ORC1 ORC3 ANKRD28 H2AZ2 ORC2 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants ADAM17 UBB NOTCH1 NEURL1B UBC DLL1 RPS27A JAG1 DLL4 NEURL1 MIB2 UBA52 MIB1 ADAM10 JAG2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle VAV2 BCR DAAM1 PIK3R1 CAV1 ARHGEF1 IQGAP3 CCDC187 ARHGEF5 ABR STARD13 STOM JUP MCAM FMNL3 FMNL2 ARHGAP1 CAVIN1 MYO9B DLC1 CIT TJP2 ROCK2 RTKN VAMP3 PKN3 ARHGAP39 ROCK1 ARHGAP5 LMAN1 ARHGAP21 ACBD5 ARHGDIA FLOT2 STX5 ARHGEF40 LBR ERBIN ARHGAP35 MCF2 ABCD3 IQGAP1 RHOA OPHN1 ARHGEF25 TMPO ARHGEF28 VANGL1 DEPDC1B ARHGAP18 PKN2 PKN1 RACGAP1 MACO1 ARHGAP26 ANLN VAPB STK10 ARHGAP32 SLK DIAPH1 TFRC AKAP13 DIAPH3 C1QBP ARHGEF10L MCF2L PREX1 FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 RHOC ARHGEF17 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP CP LTBP1 C3 APOL1 AHSG PRKCSH SERPINA10 IGFBP7 CHRDL1 WFS1 FGA FGG F2 F5 HSP90B1 PNPLA2 SERPINC1 KNG1 FSTL1 SERPIND1 FSTL3 PROC MGAT4A MELTF PDIA6 MFGE8 FN1 CST3 TGOLN2 IL6 APOA2 APOA1 PENK APOA5 LGALS1 EVA1A CCN1 CHGB IGFBP5 DMP1 IGFBP4 IGFBP2 C4A SHISA5 BPIFB2 CALU PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 IGFBP6 AMELX AMBN TMEM132A MATN3 SPP2 IGF2 HRC IGF1 PRSS23 BMP15 MEPE DNAJC3 QSOX1 RCN1 ENAM GZMH AMTN TNC FAM20C VWA1 APLP2 FAM20A PAPPA2 ITIH2 SCG3 AFP GOLM1 NUCB1 IGFBP1 SDC2 FBN1 MEN1 APP ALB PCSK9 VCAN LAMB2 GAS6 ADAM10 TF ANO8 KLK2 NOTUM CDH2 FUCA2 LAMC1 MIA3 VGF GPC3 CTSG TIMP1 CKAP4 KTN1 MBTPS1 MMP1 MMP2 FGF23 KLK3 P4HB APOB PLG SPP1 KLK13 LAMB1 SERPINA1 IGFBP3 APOE BMP4 CSF1 MSLN DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina LEMD2 CTDNEP1 LPIN1 CNEP1R1 LPIN2 CCNB1 LPIN3 PRKCA EMD LMNB1 LEMD3 CDK1 PRKCB XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics ARNT2 CYP1A1 ARNT CYP2C19 CYP2C9 CYP2C18 CYP2C8 CYP2A7 CYP2D6 CYP2A6 CYP2W1 CYP1A2 CYP2E1 CYP2J2 CYP3A4 CYP2A13 CYP3A43 AHRR CYP3A5 CYP2F1 CYP3A7 CYP2B6 AHR CYP2S1 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA BCKDHB DLD DBT NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus PSENEN PSEN2 UBB APH1A APH1B PSEN1 UBC ITGB3BP NGFR RPS27A NGF MAPK8 NCSTN UBA52 SQSTM1 TRAF6 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA ACADM HADHB HADHA HADH ECHS1 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B ABCA12 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) RAN SCD MED1 DHCR7 TBL1XR1 LSS TM7SF2 HELZ2 RXRA ACACB ACACA GPAM SP1 PPARA TGS1 FDPS CREBBP SREBF2 SEC23A INSIG2 INSIG1 CHD9 SEC24B SEC24A CARM1 SEC24D SEC24C KPNB1 NFYA NCOA1 NFYB NCOA2 MVD SC5D PMVK NFYC NCOA6 MVK GGPS1 HMGCS1 MBTPS1 MBTPS2 FDFT1 SQLE IDI1 TBL1X SMARCD3 CYP51A1 SCAP MTF1 SAR1B FASN ELOVL6 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome XIAP UACA MAPK3 AVEN DIABLO APAF1 CARD8 CASP9 APIP CYCS MAPK1 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors MLXIPL PRKACG PRKACA PRKACB PFKFB1 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis GSK3A SFPQ MAPK3 TRIM27 RNF213 CTSG MAPK1 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein PARP6 CSNK1A1 SRPK2 PARP4 PRMT1 PARP16 PARP14 SRPK1 UBE2I PARP10 PARP9 GSK3A GSK3B PARP8 SUMO1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) RAD52 PARP1 RBBP8 MRE11 RAD50 PARP2 NBN FEN1 BRCA2 LIG3 POLQ XRCC1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer SMAD2 SMAD3 TGFBR1 TGFBR2 TGFB1 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair SEM1 RAD51B RAD51C KAT5 RAD9B RAD9A HUS1 EXO1 DNA2 RHNO1 TOPBP1 RFC5 RFC3 RFC4 RFC2 ATRIP BARD1 RAD17 RBBP8 ATM ATR RAD50 NTHL1 BRCA1 NEIL3 NEIL1 RAD51 RMI2 RMI1 TOP3A MSH6 RAD51D MSH3 WRN PMS2 RPA1 RPA2 MLH1 RPA3 OGG1 RAD1 MRE11 NBN BRCA2 RAD51AP1 BRIP1 MSH2 BLM XRCC2 PALB2 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion H2AC14 H2BC12L OST4 OSTC STT3A HEYL MYC SOX10 MDM2 MYCN PIP5K1C PRKCSH TNRC6C JUP MOV10 AGO3 TCF3 AGO4 AGO1 AGO2 SNAI1 DDOST CDH11 SNAI2 CTNNA1 TNRC6A TGIF2 DAD1 TNRC6B H4C9 STRAP SMARCA4 GANAB TFAP2A H2AC20 PRDM8 FOXQ1 DNTTIP1 ILF3 ZBTB33 FOXF1 EZH2 FOXP2 BHLHE22 H2AX HOXC8 ZEB2 PKM ZEB1 POMT2 MCRIP1 FOXJ2 KLF9 POMT1 H3-3B VCL H3C8 TCF12 SIRT1 ZC3H12A H2AJ UBA52 ZNF217 ANGPTL4 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 SUZ12 UBC H2BC9 H2BC8 H2BC5 ARHGAP32 PSMA7 MOGS H2BC3 PSMB6 RPS27A PSMD8 ADAM33 H2BC1 PSMB7 PSMB4 PSMD6 CDH8 PSMB5 PSMD7 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 ADAM19 RPN1 PSMB1 PSMD1 CDH24 MPHOSPH8 H2AB1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 CDH19 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 CTBP2 PSMC2 CTBP1 CTNNB1 CDH1 ZMYM2 SP1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 SEC11A SEC11C DNM2 SRC CSNK2A1 PCSK6 FOXA2 CSNK2A2 CANX CSNK2B CTSS H2BC26 KLF4 H2BC21 CTSL KDM1A TWIST2 EED TWIST1 CTSB ARID1A H2BC17 SPCS3 MAPK1 SPCS2 H2BC12 SPCS1 H2BC13 H2BC14 MAPK3 H2BC15 H2BC11 TLE1 HDAC2 FURIN PCSK7 HDAC1 CSNK2A3 ANK3 TMEM258 KMT5A RBBP4 RB1 RBBP7 H2AC19 WT1 H2AZ2 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation CALM1 SPHK1 AHCYL1 PRKCD NRAS PRKCA PLCG1 PRKCZ ITPR1 ITPR2 ITPR3 PDPK1 HRAS KDR PRKCB RASA1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 VAV2 EGFR RAC1 MAP2K1 MAP2K2 ITGA2B L1CAM MAPK1 CSNK2A1 MAPK3 ITGB3 NRP1 ITGB1 CSNK2A2 ITGA9 PAK1 CSNK2B ITGAV NCAM1 ITGA5 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35D2 SLC35B4 SLC35A2 SLC35A3 SLC35C1 SLC35A1 SLC35B3 SLC35B2 SLC35D1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance APOBR LIPC NR1H3 MYLIP NR1H2 PCSK9 APOA1 LSR LIPA NCEH1 NPC1 AMN SOAT1 NPC2 SOAT2 UBA52 APOC1 APOC4 HDLBP APOB UBB UBC CLTC CLTA CES3 AP2A1 RPS27A AP2B1 LDLRAP1 AP2A2 AP2S1 CUBN APOE VLDLR LDLR ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG DAGLB DAGLA ABHD6 ABHD12 MGLL METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins LCN2 S100A9 S100A7A S100A8 S100A7 LTF LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism MANBA MAN2B2 MAN2B1 MAN2C1 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions CYP2C9 CYP2C19 CYP2C8 CYP2A7 CYP2D6 CYP2A6 CYP2F1 CYP2E1 CYP2B6 CYP2A13 CYP2S1 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) GUSB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis ST3GAL1 ST8SIA3 ST3GAL2 ST3GAL3 HK1 NUS1 GLB1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 DPM1 DPM2 DPM3 SLC35C1 ST6GALNAC1 CMAS NPL NANP NEU4 ST8SIA4 NANS ST3GAL6 ST6GAL2 ST8SIA1 GNE MPI ST8SIA5 MVD ALG5 NUDT14 DOLK NAGK CTSA GFPT2 AMDHD2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP SRD5A3 ST3GAL5 GMPPB FPGT GMPPA GFUS FUOM DHRSX GMDS PMM1 FCSK DOLPP1 ST6GAL1 SLC35A1 NEU2 NEU3 ST6GALNAC5 ST6GALNAC6 NEU1 DHDDS SLC17A5 ST8SIA6 ST3GAL4 PMM2 ST8SIA2 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling KLB NRAS FGF19 FGFR4 PTPN11 FRS2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB IKBKB UBB RIPK2 NFKB1 UBC PRKCI NFKBIA NGFR RPS27A NGF MYD88 UBA52 RELA IRAK1 SQSTM1 TRAF6 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 JAK2 RPS6KA1 MEF2A MEF2C TEC MAPKAPK3 SHC3 RNF41 CDC42 CUL5 SH2B3 SH2B2 RAB4B NOS3 GRIN2B NRP2 SH3GL3 SH3GL1 HGS ATP6V1H RALA PAK2 LAMA1 SPARC HNRNPF PTPRS PTPN2 IGF2 LAMC3 LYN DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PTPN12 ITGA3 ATF2 CTNNB1 LAMA2 LAMA4 SH3KBP1 LAMB2 CHEK1 ADORA2A PDGFRA YWHAB TIAL1 HSPB1 PTBP1 FGF6 RBFOX2 HNRNPH1 AKT1 ESRP2 AXL MAPKAP1 ESRP1 HNRNPA1 TIA1 PRKCD HNRNPM PRKCA CTNND1 MAPKAPK2 EPS15 PRKCE PCSK6 PDE3B IDE TIAM1 PTPRF NTRK2 BDNF CDK5R1 MAPK14 MAPK11 NAB1 NAB2 LYL1 ARC VGF TRIB1 RRAD PRKACG ASCL1 EGR2 PRKACB THEM4 EGR3 EGR4 FOSL1 FOS MAP2K1 ID2 MAP2K2 ID3 RAP1A SGK1 CDK5R2 RAPGEF1 MAPK1 BRAF IRS4 CRKL MAPK3 RICTOR FGF1 FRS3 FGF4 STUB1 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 ITCH TGFA YES1 SPRED2 SPRED1 HRAS YAP1 RASA1 VEGFA NRAS PRR5 GTF2F1 GTF2F2 LTK TNK2 FLT3 MLST8 AHCYL1 JUNB SPINT1 MST1 HPN SPINT2 MST1R MTOR PIK3R3 BAX CILP GRAP MEMO1 MXD4 NELFB CSN2 PTPRU STMN1 TCF12 ADAP1 FER NCBP1 NCBP2 GABRG3 WWP1 GABRG2 POLR2A POLR2B POLR2C POLR2D ITGA2 POLR2G POLR2I POLR2J GABRB3 GABRB2 GABRB1 FGFRL1 ESR1 GABRQ GABRA1 PGR REST NTRK1 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 AP2S1 DNAL4 SH3GL2 ROCK1 PPP2R5D PPP2CA PPP2CB PPP2R1B FAM83B CDC37 ERBIN INS ITGB1 FLT4 KIT NTRK3 ARF6 FGF2 GGA3 CYFIP2 TRIB3 CYFIP1 NCKAP1 NTF3 APOE THBS1 PRKCB ID4 ALK CD274 PSEN2 IRS1 PIK3R2 PTN PIK3CB APH1A PIK3R1 APH1B PRDM1 IL2RG HIF1A PTPRZ1 MDK MYC PRKCZ ALKAL2 ALKAL1 JAK3 FRS2 MYCN PIK3CA NCKAP1L PTPN6 ID1 ITGB3 JUP CDH5 ITGAV PSENEN F3 EGF ERBB2 PLCG1 EGFR WWOX PPP2R1A PRKACA HSP90AA1 KIDINS220 JUND ABI2 THBS2 CXCL12 UBA52 ABI1 AKT2 FOSB AKT3 GALNT3 SHC1 UBB NCF1 NCF2 MUC20 UBC NCF4 RPS27A ITPR1 ITPR2 ITPR3 PLAT ADCYAP1 ADCYAP1R1 PIK3R4 FLRT2 FLRT3 FLRT1 TNS4 STAT3 TNS3 PTPRJ ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0E1 ATP6V1G2 INSR NRP1 GRB10 BRK1 ATP6V0D1 ADAM10 COL4A5 NCK2 ATP6V0D2 ATP6V1A NCK1 ADAM17 PSEN1 ATP6V0A2 LCK ATP6V0A4 NCSTN ATP6V1D ATP6V1C1 SRC ATP6V1F ROCK2 ATP6V1C2 SOCS6 SRF ATP6V0A1 COL9A1 COL9A3 COL9A2 LAMC2 LAMC1 CSK WASF1 WASF2 WASF3 PCSK5 TPH1 TCIRG1 BAIAP2 STAT1 CTSD ATP6V0B COL4A2 ATP6V1B2 COL4A1 COL4A4 ATP6V0C COL6A2 HGFAC COL4A3 MMP9 ATP6V1B1 SHC2 COL6A1 RALGDS PTPRO GRB7 COL6A3 RALB MAPK13 RIT1 RIT2 COL6A6 COL6A5 LAMA5 LAMA3 PLG ATP6V0E2 FURIN STAM ATP6V1G3 PTK2 SPP1 LAMB3 CMA1 LAMB1 PTPRK EPS15L1 EPN1 ADAM12 LRIG1 FAM83D THBS4 AAMP THBS3 PDGFD PAG1 FAM83A SPRY1 PTPN3 VAV3 VAV1 VAV2 CAV1 FYN ARHGEF7 TAB2 MKNK1 SPRY2 FLT3LG PDGFB PAK1 EGR1 PDPK1 TLR9 CTNNA1 GAB2 PAK3 PIK3C3 KLB RANBP9 S100B PDGFRB TGFBR3 GIPC1 FGF19 FGFR4 RAB4A PTPN11 EPGN MEF2D CALM1 ANOS1 CYBB CYBA GRAP2 STAM2 RANBP10 NCOR1 KDR IGF1 GRB2 VEGFB VEGFC VEGFD DIAPH1 IRS2 DLG4 IGF1R SOCS1 ATP6AP1 EP300 SPHK1 DNMT1 PTK2B GFAP RAP1B HGF DOCK7 GAB1 MET AREG CDK5 FES FGFBP1 FGF7 FGFBP2 FGFBP3 STAT6 STAT5A FGF22 MAPK12 FGF3 STAT5B FGF10 CHD4 PTPN18 USP8 SIN3A MATK MAPK7 MAP2K5 RAC1 NRG1 NRG2 RHOA EREG PGF BTC SH2D2A FLT1 SHB NRG3 NRG4 ELMO1 ELMO2 DOCK1 CRK HBEGF PXN CBL HDAC2 PTPN1 HDAC3 PTK6 HDAC1 BCAR1 POLR2E POLR2F POLR2H NEDD4 DOCK3 POLR2K POLR2L SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET TNS3 STAT3 LAMC3 NRAS PIK3R1 PTPRJ ITGA3 LAMA2 LAMA4 SH3KBP1 PIK3CA LAMB2 RAP1B HGF DOCK7 RAB4B GAB1 RANBP9 MET SPINT1 HPN SPINT2 EPS15 RAB4A PTPN11 SRC SH3GL2 LAMC2 LAMC1 SH3GL3 USP8 SH3GL1 HGS RAC1 STAM2 RAP1A RAPGEF1 RANBP10 CRKL HGFAC ITGB1 UBA52 LAMA1 CRK SOS1 CBL ARF6 LAMA5 PTPN1 PTPN2 LAMA3 UBB STAM PTK2 MUC20 ITGA2 GGA3 UBC LAMB3 RPS27A LAMB1 LRIG1 HRAS TNS4 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane PRNP STX5 APP EMD VAMP2 VAPA SEC61G SEC61B OTOF SERP1 HMOX1 STX1A UBL4A CAMLG SGTA BAG6 GET1 GET3 GET4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 COP1 UBA52 TP53 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 ATM PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion PDCD6IP VPS37C VPS37D VPS37A VPS37B CHMP3 UBA52 CHMP6 CHMP7 CHMP5 CHMP4C VPS4B CHMP4B CHMP4A PPIA VPS4A VPS28 TSG101 UBB NEDD4L UBC MVB12B MVB12A RPS27A VTA1 CHMP2B CHMP2A UBAP1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 CCND1 PSMD12 PSMD11 UBB CDK4 PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 GSK3B PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 RMI2 MRE11 RMI1 TOP3A BARD1 NBN RAD51D BRCA2 RAD51B RAD51AP1 WRN RAD51C BRIP1 KAT5 RBBP8 ATM BLM XRCC2 PALB2 RAD50 BRCA1 EXO1 RAD51 DNA2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA1 CA5B CA3 CA5A CA2 CA4 CA7 CA6 CA9 CA14 CA13 CA12 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation ELOA NELFB ELOB NELFCD NELFA ELOC NELFE CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F ELOA2 POLR2H SUPT5H CDK9 SSRP1 POLR2K POLR2L TCEA1 ELL ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes RFC5 RFC3 UBB RFC4 RFC2 UBC RFC1 MSH6 RPS27A PCNA MSH2 PMS2 POLI UBA52 POLH MLH1 POLD3 EXO1 REV1 MAD2L2 POLD2 REV3L OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence H2AC14 H2BC12L H2AC8 MAP2K3 H2AC6 H2AC7 MAP2K4 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 MDM2 CDKN2D MDM4 TXN CDKN2C KDM6B TNRC6C MOV10 AGO3 TNIK AGO4 AGO1 TNRC6A TNRC6B CDK6 H4C9 TP53 BMI1 RING1 MAPKAPK2 H2AC20 TFDP1 TFDP2 RNF2 EZH2 H2AX MAP4K4 CBX8 E2F1 PHC2 E2F3 CBX6 PHC1 MAPK14 H2BC26 JUN MAPK11 CBX4 CBX2 H2BC21 H3-3B PHC3 H3C8 CDKN2A FOS EED IFNB1 H2BC17 MAPK1 H2BC12 H2BC13 H2BC14 MAPK3 H2BC15 H2AJ UBA52 E2F2 H2BC11 MAP3K5 CDKN2B H3C15 UBB CDK4 SUZ12 UBC H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 RPS27A H2BC1 MINK1 MAPKAPK5 RBBP7 H2AC19 MAP2K6 H2AB1 H2AZ2 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins CCNT1 CDK9 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription SNW1 HEY2 EP300 PBX1 MAMLD1 DLGAP5 PLXND1 NOTCH1 WWC1 PTCRA MAML2 MAML1 RBPJ HEYL FABP7 STAT1 HES5 MAML3 KAT2B NOTCH3 KAT2A HES1 CREBBP HEY1 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria PMAIP1 TP53 E2F1 TFDP1 TFDP2 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBB TICAM2 UBC LY96 TAB3 TAB2 TAB1 RPS27A TICAM1 CD14 TLR4 UBA52 MAP3K7 IRAK2 TRAF6 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway VAV2 SPHK1 PIK3R2 PIK3CB NRAS PIK3R1 CAV1 FYN MAPKAPK3 PRKCZ CTNNB1 PIK3CA NCKAP1L ITGB3 PTK2B CDH5 JUP PRR5 PAK1 PDPK1 CDC42 BRK1 CTNNA1 HSPB1 ITGAV NCK2 PAK3 MLST8 NCK1 AKT1 AXL MAPKAP1 AHCYL1 NOS3 PRKCD CTNND1 PRKCA PLCG1 MAPKAPK2 ROCK2 MAPK12 PRKACA MTOR ROCK1 MAPK14 MAPK11 HSP90AA1 WASF1 WASF2 CALM1 WASF3 CYBB PRKACG CYBA BAIAP2 RAC1 PRKACB THEM4 RHOA SH2D2A PAK2 ABI2 SHB RICTOR ELMO1 ELMO2 DOCK1 SHC2 CRK ABI1 MAPK13 AKT2 KDR PXN AKT3 NCF1 PTK2 NCF2 BCAR1 NCF4 CYFIP2 TRIB3 CYFIP1 NCKAP1 ITPR1 ITPR2 ITPR3 VAV3 HRAS PRKCB VAV1 RASA1 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 LUM OMD ST3GAL3 PRELP ACAN FMOD OGN KERA COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation CTSL CTSK COL16A1 COL12A1 CTSD CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 MMP10 PRSS2 MMP12 MMP11 PHYKPL MMP14 MMP13 COL23A1 MMP15 ADAM10 MMP19 ADAM17 COL15A1 TMPRSS6 ADAM9 COL17A1 FURIN COL13A1 COL19A1 COL26A1 ELANE COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 MMP20 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex PDK1 PDHX DLAT PDK4 DLD PDP1 PDP2 GSTZ1 PDHA2 PDHA1 PDHB PDPR SIRT4 PDK3 PDK2 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle MID1IP1 CPT1A PRKAB2 PPARD RXRA CPT1B PRKAA2 THRSP PRKAG2 SLC25A20 SLC22A5 CPT2 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin EEF2 HSP90AB1 CD9 TXNRD1 HBEGF HSP90AA1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade IRS1 PIK3R2 PIK3CB PIK3R1 THEM4 FRS2 PIK3CA FGF1 FGF4 FLT3LG FGF16 FGF9 PDPK1 FGF18 FGF20 FGF23 TLR9 FLT3 AKT2 GAB2 FGF6 FGF2 PIK3C3 KLB GAB1 FGF19 FGFR4 TRIB3 PTPN11 IRS2 FGF7 PDE3B FGF22 FGF3 FGF10 PIK3R4 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events RBP4 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A EIF1AX RPL22L1 EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling ACVR2A INHA TGFBR3 INHBA TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 TLR10 APP MAP3K8 DUSP6 MAP2K3 DUSP7 MEF2A MAP2K4 NFKB2 UBE2N MEF2C TAB3 MAPKAPK3 NFKBIA TAB2 MAPK9 TAB1 ATF2 MAPK8 ALPK1 MAP2K7 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 CHUK NKIRAS2 IKBIP IRAK4 PELI1 LRRC14 TRAF6 USP14 PELI3 PELI2 IKBKB NLRC5 TP53 USP18 TIFA MAP3K1 IKBKG S100B RIPK2 SAA1 NOD1 NOD2 MAPKAPK2 PPP2R1A BTRC PPP2R5D RELA MAPK14 SKP1 PPP2CA JUN MAPK11 PPP2CB PPP2R1B MAPK7 FBXW11 NFKB1 FOS TLR5 MAP2K1 TRAF2 MAPK1 CASP8 MAPK3 UBA52 MAP3K7 CUL1 UBB UBC RPS27A ECSIT UBE2V1 MAP2K6 IRAK1 IRAK2 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis LHPP PPA2 PPA1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 TBP SSB NFIX NFIA NFIB NFIC BRF2 BDP1 POLR1C POLR1D CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H GTF3C1 POLR3K GTF3C2 POLR2H GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR2K ZNF143 POLR2L BRF1 POU2F1 GTF3A SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants STAT3 BCR PIK3R1 LRRFIP1 STAT1 PIK3CA ZMYM2 STAT5A STAT5B CPSF6 FGFR1OP2 GAB2 CEP43 TRIM24 CUX1 MYO18A INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 CPSF4 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD MAT1A VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways ERCC3 ELK1 PQBP1 ERCC2 RNASEK SRRT KPNA7 KPNA4 KPNA5 KPNA3 CLU SNRNP200 CTNNBL1 SIGMAR1 PRCC MERTK KDELR1 CCAR1 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 TLR1 SYMPK RBM10 PAF1 RETREG1 DHX15 TLR2 DHX16 CD33 ZBP1 WBP11 CD8B HNRNPUL1 RTN3 DDX3X DDX46 DDX42 RBM17 DYNLT1 BUD31 RBM22 DDX23 CSTF2T RRBP1 SMNDC1 U2SURP CLP1 CD4 TYRO3 PSMD12 PSMD11 MRC1 PSMD14 PSMD13 SF3B4 SF3B5 ARF1 SF3B2 RPLP1 PSMA7 SF3B3 RPLP0 SF3B6 PSMB6 BRD4 PSMD8 SF3A3 SF3A1 PSMB7 SF3A2 PSMB4 XAB2 PSMD6 RPLP2 PSMB5 HSPA1B PSMD7 CLEC4M PSMB2 CLEC5A PSMB3 PSMD2 NCL PSMD3 VTN PSMB1 PSMD1 BAG2 CHERP RCAN3 ADRM1 EIF4G3 PSMA5 EIF4G2 EIF4E3 SEM1 PSMA6 PSMA3 PSMC5 CX3CR1 PSMA4 PSMC6 PSMC3 PUF60 PSMA1 SNRPB2 PSMA2 PSMC4 PSMC1 AQR PSMC2 C4B_2 CTNNB1 NMI SH3KBP1 PRPF19 PCF11 PACS1 YWHAB MAPRE3 ELAVL1 XPO1 AKT1 AXL HDLBP NUP214 EFTUD2 PDIA3 YWHAZ CD300A XRN1 DPM1 DPM2 PABPC1 DPM3 RPL22L1 DNAJC10 ELAVL2 S1PR1 HSPA8 KPNB1 ITGA4 HSPA1A EIF4G1 RBX1 CSNK1A1 ITCH SLC25A4 CUL3 CCNK CCNT2 NUP107 CCNT1 NUP188 GTF2B RCC1 BANF1 KPNA1 SUPT16H LIG1 NUP210 LIG4 GTF2F1 GTF2F2 RPL23A NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 POM121 TSG101 SUPT4H1 NEDD4L AAAS GTF2E1 GTF2E2 NUP160 POM121C NUP85 TPR NUP88 XRCC6 XRCC4 NUP155 XRCC5 VTA1 HMGA1 ELOA2 NUP153 SUPT5H CDK9 CHMP2B CHMP2A NMT1 TAF4B NMT2 FEN1 ELL TAF7L NUP62 ELOA NELFB ELOB NELFCD NELFA ELOC CCR5 NELFE TAL1 NDC1 SEC13 PDCD6IP NCBP1 NUP133 RPL27A NCBP2 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 TAF1L POLR2A POLR2B NUP42 POLR2C POLR2D MVB12B MVB12A POLR2G NUP43 POLR2I TAF9B POLR2J RAE1 RANBP2 RANBP1 RNGTT TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 UBAP1 PPP1CA TAF7 NRBP1 NUP35 TCEA1 TAF6 TAF5 TAF4 TAF3 RAN TAF2 NUP37 TAF1 CHUK UBA7 HSPA5 UBE2L6 ISG15 IFIH1 HERC5 IKBKB TRIM25 ARIH1 IKBKG RIGI CLTC CLTA AP2A1 AP2B1 AP2A2 AP2S1 PARP1 RPL26L1 RPL4 ITGB1 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL6 RPL7 SMAD4 RPL36 SMAD3 RPL35 RPL38 RPL37 RPL39 YBX1 CAMK2B CAMK2D RPL21 CAMK2A RPL23 RPL22 MED8 MED9 CAMK2G ACOT2 RPL24 RPL27 PIK3R1 RPL26 RPL29 RPL28 JAK3 PLCG2 PTPN6 PROS1 CDK19 RPL41 RPL3L TGFB1 F2 RUNX1 EIF2AK2 RELA RPL10 RPL12 RPL11 RPL14 RPL13 NFKB1 RPL15 RPL18 RPL17 RPL19 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 RPS16 TBK1 RPS19 SNRPD2 RPS18 SNRPD1 AKT2 AKT3 SNRPD3 RPS11 B2M GOLGA7 RPS10 RPS13 VPS39 RPS12 VPS18 HLA-H ST6GAL1 IPO5 HLA-B GRSF1 DNAJC3 HLA-C MOGS HLA-A ATG14 HLA-F HLA-G HLA-E ACE2 RPS4Y2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 RPS4Y1 IFIT1 LARP1 IFIT3 VPS11 IFIT2 VPS36 ST3GAL4 SFN SNF8 VPS25 ST3GAL1 ST3GAL2 VPS16 ST3GAL3 SRPK2 EDEM2 PARP16 PARP14 SRPK1 PARP10 RPS26 RPS25 RPS28 RPS27 RPS29 SDC1 RPL7A RPS20 RPS21 RPS24 ATP1B3 RPS23 IFNA5 ATP1B2 NRP1 ATP1B1 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 MAGT1 RPL37A IFNA8 MAP1LC3B TRIM4 HAVCR1 IKBKE JAK1 TOMM70 RPL36A PARP6 PARP4 PRMT1 RIPK2 SFTPD ANO8 RPL35A ANO9 ANO6 TYK2 ANO7 IMPDH1 ZDHHC11 ANO4 IMPDH2 PARP9 ANO5 IL17RC ANO2 PARP8 ANO3 IL17RA ANO1 SIKE1 CANX TLR8 TLR7 FXYD4 ZDHHC20 RPS27L FXYD3 TMPRSS2 RNF135 FXYD2 RPS15A GPC1 FXYD1 MGAT5 FXYD7 RPS3 FXYD6 GPC3 ANO10 GPC2 GPC5 MGAT1 RPS2 GPC4 MGAT2 GPC6 STAT1 IFNB1 STAT2 TJP1 NLRP12 STING1 ZDHHC9 IL17F FAU AGRN CRB3 IL17A ATP1A4 TUSC3 ATP1A3 GEMIN2 KPNA2 ATP1A2 MAP3K7 RPS9 ATP1A1 IFNA14 RPS7 RPS8 IFNA16 RPS5 VPS33A IFNA17 RPS6 VPS33B RPSA SCAP ZCRB1 TUFM TMEM258 GEMIN4 RPL39L SNRPG GEMIN5 GEMIN6 SNRPE UBE2V1 GEMIN7 MASP1 SNRPF GEMIN8 ISCU IFNA10 IFNAR1 SNRPB FKBP1A VCP DDX5 FUT8 TKFC IRAK1 CYSLTR1 IRAK2 MAN2A1 G3BP1 SMN2 G3BP2 NLRP3 IFNA21 SYK UVRAG OST4 CAV1 HCK MAVS OSTC FYN STT3A UBE2N TAB3 TAB2 TAB1 STT3B PALS1 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH RPS4X YWHAQ NFKBIB MBL2 YWHAH PDPK1 RPS3A DDOST IRF3 TLR9 DAD1 TRAF3 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB VHL SEC24B SEC24A CNBP GALNT1 PTPN11 MGAT4C MGAT4A MGAT4B CLINT1 VPS41 AP1G1 VPS45 SEC24D SEC24C AP1S2 AP1S1 AP1S3 AP1B1 RAB5C AP1M2 AP1M1 PYCARD CASP1 NFE2L2 EEF1A1 KEAP1 SNW1 KDM1A RAC1 ELMO1 ATG7 PHF21A RCOR1 FASN HMG20B EIF4A3 JAK2 CDC40 SRRM1 SRSF2 SRSF3 SRSF4 DOCK2 SRSF5 SRSF6 SRSF7 CUL5 SRSF9 UBA6 UBA5 UBR4 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 UBA3 UBA1 ATP6V1H LY96 PAK2 RIPK1 CD14 TLR4 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 HNRNPF HNRNPA2B1 IGKV1-12 IGHV3-7 IGHV3-9 SNRPA1 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN RIPK3 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 MLKL IGLV7-43 IGKV1D-12 NFKBIA IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 DAXX IGLC3 IGLC1 IGLC2 PTBP1 IGKV3D-20 HNRNPH1 MAPKAP1 IGLV3-19 HNRNPA1 IGKV2-30 IGHV2-70 HNRNPM IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 IGLC6 RPTOR RICTOR NPM1 SOS1 P4HB PRR5 MLST8 MED19 MED15 MED18 MED11 MTOR PML TLR3 MED26 EIF4A2 MED29 EIF4A1 H2AC17 MED28 H2AC12 MED22 MED25 MED21 H2AC25 H2AC21 PABPN1 EIF4E ARID4A H2AC1 BRMS1 UBE2I NR3C1 SUMO1 H2BC18 SP1 PPIA REST SLC25A5 CSNK2A1 CSNK2A2 SLC25A6 ROCK1 CSNK2B RBMX EXOC1 GBF1 NPLOC4 UFD1 MED13L DYNC1LI1 DYNC1LI2 HNRNPC EGFR YWHAE DYNLL2 PPP1CB NEK2 BTRC YWHAG SKP1 HSP90AA1 TUBB CBX1 DYNLL1 FKBP4 TAOK1 UBA52 DYNC1I2 UBB UBC RPS27A DYNC1H1 BCL2L1 IFNGR1 IFNGR2 HSPG2 NCK1 LCK ROCK2 CTSL BTK MMP9 PPIB FURIN P4HA1 P4HA2 P4HA3 RB1 CCNH H2AC19 CCNC VAV1 H2AC14 TRIM28 MED1 MED4 MED6 MED7 RPL10L RPL10A PPP1CC CD28 CREBBP DYNC1I1 H4C9 BCAP31 H2AC20 EZH2 RAB5A MED16 MED17 MED12 MED14 MED13 MED10 HYOU1 PRKG2 H3C8 ATL2 CRBN NUDT21 FNTA FNTB APOA1 MED27 LY6E RPL13A FUS MED23 NACA ISY1 NCOR2 BCAS2 C1S MED24 HNRNPA0 HNRNPA3 NCOR1 GPKOW CDC5L MED20 PDCD1 C4A CPSF7 GPS2 H3C15 TBL1X SF3B1 DHX9 MBD3 BST2 SUZ12 CD209 H2BC9 H2BC8 CALR H2BC5 SUGP1 IGHM H2BC3 H2BC1 GTF2H1 GTF2H2 GTF2H3 IGHD GTF2H4 PEX19 GTF2H5 GATAD2B GATAD2A IGF1R IL6R DNAJB11 RPL18A PPIE RPL36AL PPIH PPIG ARID4B EP300 SUN2 H2AC8 HNRNPU H2AC6 HNRNPR H2AC7 SAP30 MAP1B TBL1XR1 BTF3 HNRNPL HNRNPK HNRNPD WDR33 MED30 GAS6 MED31 PHF5A AUP1 IPO7 PAPOLA TXNL4A VIM SNRPN SUDS3 RAB5B CDK8 CDK7 PLRG1 SKIC8 DNAJC8 CEBPD FIP1L1 SEC11A MNAT1 SEC11C PPIL1 SNRNP40 GSK3B DNAJA2 NPIPB3 PPIL3 PSIP1 PPIL4 PPIL6 CHD4 SRRM2 CHD3 IL1R1 COG1 CRNKL1 H2BC26 CSTF3 CSTF2 H2BC21 CD79B CD79A CSTF1 PTGES3 CHMP1A HNRNPH2 TLR6 TBP EED C1QA EMC4 H2BC17 SPCS3 SPCS2 H2BC12 SPCS1 H2BC13 CWC25 H2BC14 CWC27 H2BC15 CWC22 COMT H2BC11 PRPF6 PRPF8 CPSF4 CPSF1 CDC73 RPL9P9 CPSF3 CPSF2 CWC15 HDAC2 HDAC3 CGAS BLNK LEO1 HDAC1 RBM5 OAS2 MTA1 GBP1 RBBP4 C4BPA C4BPB SAP30L CLDN1 POLR2E POLR2F SAP18 POLR2H RBBP7 MTA2 MTA3 POLR2K GRPEL1 POLR2L DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM MMAA MMUT POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation ZIC3 STAT3 NANOG SALL1 SALL4 FOXD3 EPHA1 DPPA4 POU5F1 SOX2 CRIPTO FGF2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication H2AC14 CDT1 CDC6 H2BC12L KPNA1 LIG1 H4C9 MGME1 RNASEH1 EXOG POLG RFC5 RFC3 RFC4 RFC2 H2AC20 H2AX ANAPC15 CDC7 ANAPC16 UBE2D1 ANAPC10 ANAPC11 SKP1 FZR1 CDC23 FEN1 CDC26 CDC27 H3-3B ANAPC7 UBE2C H3C8 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 H2AJ UBA52 POLRMT POLG2 TWNK CCNE2 CCNE1 CUL1 SSBP1 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC POLE H2BC9 RFC1 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 POLD3 H2AB1 POLD4 POLD2 ADRM1 PSMA5 SEM1 PSMA6 POLE4 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 POLE2 H2AC6 PRIM2 PSMC3 H2AC7 PSMA1 PRIM1 POLE3 PSMA2 POLA1 PSMC4 POLA2 PSMC1 PSMC2 KPNA6 SKP2 MCM10 DBF4 RPA4 POLD1 DNA2 KPNB1 H2BC26 GINS1 GINS2 CDC45 MCM7 MCM8 H2BC21 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 TOP3A RBX1 H2BC17 PCNA H2BC12 H2BC13 H2BC14 H2BC15 RPA1 H2BC11 RPA2 RPA3 CDK2 CCNA2 CCNA1 GMNN H2AC19 ORC5 ORC4 ORC6 ORC1 ORC3 H2AZ2 ORC2 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling STAT3 LIFR JAK1 CNTFR JAK2 IL6 TYK2 IL11 STAT1 CNTF OSMR PTPN11 LIF IL6ST CRLF1 CTF1 CLCF1 IL31 IL6R IL11RA IL31RA OSM CBL SOCS3 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway CASP8 IL1B NFKB1 MALT1 RELA PYCARD PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis POMC INHA LHB CGA INHBB INHBC PCSK1 INHBA TSHB INHBE CGB8 FSHB BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization ACOT2 TOMM20 TOMM22 ACOT4 TOMM40 TOMM7 TOMM5 ATAD1 TOMM6 PEX16 FIS1 PEX11B GDAP1 PEX26 PXMP4 CROT SAMM50 DDO ATP5F1A ATP5F1B CAT MTX1 EPHX2 EMD HSD17B4 ABCD1 PEX2 SERP1 TIMM21 BAAT STX1A PEX10 PEX12 UBE2D1 PEX13 PEX14 HSPA9 NUDT7 ACBD5 NOS2 STX5 AGPS USP9X ABCD3 ZFAND6 MPV17 PEX1 MTX2 LONP2 PEX7 PEX6 CHCHD3 UBA52 HSCB UBE2D2 HAO1 COX19 HAO2 ABCD2 PEX3 CRAT UBB CS IDH3G COX17 UBC EHHADH VAPA NUDT19 RPS27A UBE2D3 PEX19 UBL4A CAMLG SGTA BAG6 GET1 SLC27A2 GET3 DHRS4 GET4 ACAA1 APP VAMP2 SEC61G SEC61B ACOX2 ATP5MC1 ACOX3 CYC1 ACO2 TOMM70 OTC CHCHD4 CHCHD5 CHCHD7 TIMM17B COA6 CMC4 CMC2 PECR PAM16 OTOF TIMM23 TIMM13 TIMM50 PITRM1 GRPEL2 DNAJC19 COA4 IDE TIMM8B PIPOX SLC25A6 TIMM8A GNPAT CHCHD10 AGXT TIMM44 GFER TIMM10B FXN CHCHD2 ECH1 LDHD TIMM17A PAOX TIMM22 TIMM9 HACL1 TIMM10 HMGCL VDAC1 PMPCB PMPCA HMOX1 PHYH ACOX1 TYSND1 PRNP BCS1L SLC25A17 SLC25A12 SCP2 IDH1 SLC25A4 SLC25A13 GSTK1 ACOT8 NDUFB8 DECR2 HSPD1 GRPEL1 COQ2 AMACR DAO PXMP2 TAFAZZIN SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway DAB1 SH3KBP1 VLDLR FYN RELN SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer SMAD2 SMAD3 TGFBR1 TGFBR2 TGFB1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome CASP1 PYCARD AIM2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor CALM1 DLG4 GRIK5 GRIK3 GRIK4 NCALD DLG1 GRIK1 GRIK2 DLG3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis DAGLA DAGLB DGKG DGKE DGKD DGKB DGKA PRKCD PRKCH ABHD12 PRKCE PRKCQ ITPR1 DGKZ ITPR2 DGKQ ITPR3 DGKK DGKI DGKH ABHD6 TRPC7 RASGRP2 RASGRP1 TRPC6 TRPC3 MGLL LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis ST3GAL3 FUT2 FUT4 B3GALT4 FUT3 B3GALT5 FUT6 B3GALT2 FUT5 B3GALT1 ST6GALNAC6 FUT7 FUT9 B4GALNT2 ST3GAL6 ST3GAL4 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins RAP1B PTK2 VWF ITGA2B RAP1A SRC ITGB3 APBB1IP SOS1 FGB FGA TLN1 FGG FN1 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism FADS1 ELOVL1 ELOVL5 ELOVL2 FADS2 ELOVL3 ACSL1 ABCD1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein PRKCSH MGAT1 CANX GANAB MOGS RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SRRT CCNK CCNT2 CCNT1 GTF2B PCF11 SP1 GTF2F1 GTF2F2 SUPT4H1 INTS1 GTF2E1 INTS3 GTF2E2 INTS2 CDK7 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 SUPT5H CDK9 NABP2 NABP1 PHAX ZNF143 ELL2 POU2F1 ELL3 ZC3H8 ELL RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 TBP NCBP1 NCBP2 GTF2A1 GTF2A2 TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F TAF13 POLR2H TAF11 TAF8 POLR2K POLR2L TAF6 TAF5 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism NAPSA CCDC59 PGA3 PGA5 ADA2 PGA4 ADGRF5 ADORA2B CKAP4 ZDHHC2 GATA6 P2RY2 ADRA2C ADORA2A ADRA2A SFTPB SFTA3 SLC34A2 SFTPA2 SLC34A1 SFTPC CSF2RB SFTPA1 CSF2RA CTSH SFTPD ABCA3 DMBT1 TTF1 LMCD1 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses SIPA1L1 LRRTM3 LRRTM4 LRRTM1 LRRTM2 HOMER3 DLGAP1 DLGAP3 DLGAP2 GRIA1 DLGAP4 SHANK2 STXBP1 EPB41L1 SHANK1 NRXN1 NLGN3 GRIA3 NLGN1 GRIA4 NLGN2 EPB41 NRXN3 DLG1 NRXN2 LRFN3 BEGAIN LRFN2 EPB41L5 LRFN4 EPB41L2 LRFN1 PDLIM5 NLGN4Y NLGN4X HOMER1 HOMER2 DBNL SYT7 GRIN1 SYT12 APBA1 APBA3 APBA2 GRIN2A PTPRD PPFIBP2 SLITRK2 EPB41L3 SLITRK1 IL1RAPL2 SLITRK4 GRIN2B SLITRK6 LRRC4B STX1A PTPRF SYT9 SLITRK3 SLITRK5 PPFIBP1 FLOT2 RTN3 GRM1 GRM5 SYT10 SHARPIN SHANK3 NTRK3 IL1RAPL1 CASK PTPRS LIN7A LIN7C GRIN2C GRIN2D DLG2 DLG3 DLG4 SYT1 FLOT1 PPFIA1 PPFIA4 LIN7B SYT2 PPFIA3 PPFIA2 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 MDM2 JUP CTNNA1 CTNND1 MTBP RACK1 CBLL1 EPS15 BANP DNM2 SRC CTSS CTSL VCL CTSB UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway IFNA21 MAVS MED1 MED4 MED6 MED7 HSP90AB1 PPP1CC CDK19 CUL5 IRF3 CREBBP BCAP31 BECN1 EGFR MED19 MED15 MED18 PPP1CB MED11 EIF2AK2 TLR2 RAB5A MED16 MED17 MED12 MED14 TLR3 MED13 MED26 MED10 HSP90AA1 MED29 MED28 MED22 RAB5C ELOB MED25 ELOC MED21 LY96 MED27 MED23 CD14 UBA52 MED24 TLR4 MED20 UBB UBC CD209 RPS27A CLEC4M SDC4 IGF1R NCL SDC2 SDC3 PPP1CA EP300 CX3CR1 MAP1B SDC1 IFNA5 IFNA4 IFNA7 MED30 IFNA6 MED31 IFNA1 IFNA2 UBE2L6 IFNA8 ISG15 HSPG2 IFIH1 XPO1 HERC5 JAK1 TRIM25 RAB5B ARIH1 RIGI CDK8 TYK2 SEC11A SEC11C CSNK2A1 CSNK2A2 HSPA8 KPNB1 TLR7 CSNK2B GPC1 GPC3 GPC2 GPC5 TLR6 GPC4 GPC6 IFNB1 RBX1 STAT2 SPCS3 SPCS2 SPCS1 H2BC15 AGRN IFNA14 IFNA16 IFNA17 FURIN OAS2 IFNA10 IFNAR1 MED8 CCNC MED9 MED13L DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type CHST14 CSPG5 DCN NCAN BGN VCAN BCAN REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion FFAR1 GLP1R VAMP2 STXBP1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 ADRA2C GNG7 ADRA2A GNA11 AKAP5 GNG8 SNAP25 AHCYL1 PRKCA KCNJ11 KCNC2 MARCKS GNAI1 GNAI2 STX1A PLCB3 PRKACA GCG PLCB1 PLCB2 KCNS3 CD36 PRKACG PRKACB INS IQGAP1 SLC2A1 RAP1A SLC2A2 PRKAR1B RAPGEF3 PRKAR1A RAPGEF4 CHRM3 ADCY8 ADCY6 KCNB1 ADCY5 ABCC8 PRKAR2A KCNG2 GNG10 CACNA1A PRKAR2B CACNB2 CACNA1D CACNB3 CACNA1C GNG12 GNAS CACNA1E GNG11 GNG13 GNB2 GNAQ ITPR1 GNB1 ITPR2 SYT5 GNB4 ITPR3 GNB3 GNB5 CACNA2D2 GNGT1 ACSL4 GNGT2 ACSL3 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity XIAP UACA MAPK3 AVEN DIABLO APAF1 CARD8 CASP9 APIP CYCS MAPK1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery ELOA NELFB ELOB NELFCD NELFA ELOC NELFE CCNT1 SUPT16H GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J POLR2E POLR2F ELOA2 POLR2H SUPT5H CDK9 SSRP1 POLR2K POLR2L TCEA1 ELL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation AIMP1 LARS1 AIMP2 EPRS1 KARS1 IARS1 AARS1 HARS1 YARS1 WARS1 RARS2 RARS1 GARS1 AARS2 NARS1 PARS2 SARS1 CARS1 MARS2 FARSA DARS2 TARS1 YARS2 VARS1 HARS2 FARSB FARS2 WARS2 LARS2 SARS2 NARS2 MARS1 TARS2 EEF1E1 IARS2 VARS2 PPA2 CARS2 EARS2 PPA1 DARS1 QARS1 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome ABCC9 KCNJ11 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling HLA-DQB2 HLA-DRB1 HLA-DQB1 FCGR1BP JAK2 FCGR1A SP100 PIAS1 PTAFR TRIM8 TRIM6 IRF1 IRF5 PTPN6 TRIM5 IRF2 TRIM2 SUMO1 TRIM3 IFNGR1 IFNGR2 IRF3 RAF1 IRF7 JAK1 TRIM25 PRKCD IRF4 PTPN11 PML OASL OAS1 OAS3 CIITA GBP3 TRIM68 GBP5 GBP7 TRIM21 TRIM62 TRIM46 TRIM48 MAPK1 TRIM45 TRIM35 MAPK3 TRIM38 TRIM31 IFI30 TRIM34 ICAM1 TRIM29 TRIM26 TRIM22 IFNG TRIM17 TRIM14 CD44 SOCS3 NCAM1 TRIM10 B2M PTPN1 MT2A HLA-H OAS2 HLA-B HLA-C GBP2 SMAD7 GBP1 HLA-A GBP4 HLA-F HLA-G YBX1 HLA-E HLA-DQA2 VCAM1 CAMK2B HLA-DQA1 HLA-DPA1 GBP6 CAMK2D CAMK2A SOCS1 HLA-DRB5 IRF8 HLA-DRB4 MID1 HLA-DPB1 CAMK2G HLA-DRA IRF6 HLA-DRB3 IRF9 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones MBTPS2 HSPA5 MBTPS1 ATF6B TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification SEC16A ST8SIA3 CAPZB GOSR2 SEC23IP DYNC1LI1 CNIH1 DYNC1LI2 CNIH2 FOLR1 CNIH3 BET1 SPTB DYNC1I1 F5 KDELR1 CAPZA1 F8 SEC23A CAPZA2 ANK2 CD59 CD55 DYNLL2 SEC24B SEC24A SPTBN4 SPTBN5 ACTR1A SEC31A MGAT4C MGAT4A MGAT4B SEC24D SEC24C COPB1 MANEA LMAN1 NAPA STX5 YKT6 CSNK1D SPTA1 B4GALT2 B4GALT3 SEC13 DYNLL1 DCTN1 GOLGB1 CTSZ DYNC1I2 DCTN2 DCTN3 ST6GAL1 ARF3 ANK1 ARF1 B4GALT6 B4GALT4 B4GALT5 DYNC1H1 SAR1B MAN1A2 MAN1C1 MAN1A1 ST3GAL4 GOLGA2 TFG SEC22B GRIA1 FUT3 LHB NSF TRAPPC2L TBC1D20 B4GALT1 AREG ARFGAP3 ARFGAP2 TMED2 TRAPPC2 TRAPPC3 TRAPPC1 COG1 TRAPPC4 TRAPPC5 MGAT5 MIA2 MIA3 MGAT1 TRAPPC9 ARF4 TMEM115 MGAT2 INS CGA KDELR2 COPB2 TRAPPC6A COPA SPTBN2 COPE TRAPPC6B ARFGAP1 TMED3 TMED7 SCFD1 TMED9 RAB1A COPZ2 RAB1B SPTBN1 COPZ1 CTSC ARF5 ANK3 PREB KDELR3 TRAPPC10 CAPZA3 GBF1 ACTR10 TGFA MCFD2 SERPINA1 GOSR1 PPP6C PPP6R1 COL7A1 CHST10 PPP6R3 ARCN1 LMAN1L COPG2 GORASP1 COPG1 SEC22A SEC22C SPTAN1 NAPB TMED10 COG8 LMAN2L COG7 DCTN6 STX17 COG6 FUT8 MAN2A2 DCTN5 USO1 COG5 DCTN4 NAPG MGAT3 COG4 ST8SIA6 LMAN2 COG3 SEC31B CHST8 COG2 MAN2A1 ANKRD28 FUCA1 SEC16B ST8SIA2 BET1L CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events CALM1 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 KPNA2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A PRKCD PRKAR2B PRKCA CAMKK1 CAMKK2 NBEA CAMK2B CAMK2D PRKX CAMK2A PRKACA PRKCG PDE1C CAMK2G GRK2 PDE1B PDE1A CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants ALK LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy CETN1 VPS37C IFT88 VPS37D VPS37A VPS37B CHMP3 UBA52 CFTR CHMP6 CHMP7 RNASE1 CHMP4C CHMP4B PLIN2 CHMP4A VPS28 TSG101 UBB UBC MVB12B MVB12A PCNT RPS27A HDAC6 PLIN3 PARK7 ARL13B CHMP2B HBB HSPA8 CHMP2A UBAP1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSF SUMF2 ARSG SUMF1 ARSD ARSA ARSB ARSL ARSJ ARSK ARSH STS ARSI CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism SARDH ALDH7A1 SLC44A1 SLC44A2 BHMT DMGDH SLC22A4 CHDH DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 GAB1 NRAS PIK3R1 PLCG1 PTPN11 FRS2 PIK3CA FGF1 FGF7 FRS3 FGF4 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants PDGFRA DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations DAG1 MGAT5B POMGNT1 POMT2 POMT1 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling TGFBR3 GIPC1 FGF2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC17A1 SLC34A3 SLC34A2 SLC20A1 SLC20A2 SLC34A1 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen GP9 GP1BA VWF GP1BB GP5 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation IKBKG RIPK2 NOD1 MAP2K3 NOD2 MAPKAPK2 UBE2N TAB3 MAPKAPK3 TAB2 TAB1 UBE2V1 MAPK14 MAP3K7 MAP2K6 MAPK11 IRAK1 IRAK2 TRAF6 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 HEY2 EP300 SNW1 PSEN2 PBX1 MAMLD1 DLGAP5 TACC3 WWC1 APH1A NEURL1B APH1B PTCRA HEYL WWP2 STAT1 KAT2B KAT2A MIB2 UBA52 ADAM10 CREBBP PSENEN PLXND1 UBB NOTCH1 EGF MAML2 PSEN1 EGFR UBC MAML1 RBPJ DLL1 FABP7 RPS27A HES5 NCSTN JAG1 YBX1 DLL4 MAML3 NOTCH3 NEURL1 HES1 MIB1 HEY1 JAG2 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A DDIT3 CEBPG CEBPB EIF2S3 EIF2S2 RPL10 EIF2S1 RPL12 RPL11 RPL14 RPL13 RPL15 ATF3 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 ASNS RPS26 RPS25 RPS28 RPS27 ATF2 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A RPL36A RPL35A RPL22L1 RPS27L RPS15A RPS3 RPS2 EIF2AK4 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 IMPACT RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 TRIB3 RPL39L RPL38 RPL37 RPL39 ATF4 RPL21 RPL23 RPL22 GCN1 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events CALM1 PPP2R1B PRKAR2A PRKAR2B PRKACG PRKACB CDK5 PDE4A PPP3CA PPP3CB PDE4D PDE4C PRKAR1B PPP2R1A PPP1R1B PRKAR1A PPP3CC PRKACA PPP2R5D PPP1CA PPP2CA PPP2CB PPP3R1 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 HGF GAB1 MET PTPN11 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes AKT1 PIEZO1 CACNG7 CACNB2 CACNB3 SPP1 PANX1 P2RX7 ITGB3 GJA1 ITGB1 CACNB1 CACNA2D1 CACNA1H ITGAV HSPG2 ITGA5 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling PGK1 RHEB TNRC6C MOV10 AGO3 AGO4 PRKAB1 AGO1 RRAGA AGO2 RRAGC YWHAB RRAGB TNRC6A TNRC6B RRAGD MLST8 AKT1 PRKAG2 AKT1S1 EIF4EBP1 PRKAA1 STK11 MTOR PRKAG1 PPM1A PRKAG3 EEF2K RPTOR EIF4G1 TSC2 TSC1 PRKAA2 CAB39L STRADA STRADB EIF4E EIF4B AKT2 AKT3 LAMTOR2 LAMTOR1 RPS6 LAMTOR4 LAMTOR3 LAMTOR5 PRKAB2 CAB39 FKBP1A SLC38A9 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CALM1 CAMK2B CAMK4 KPNA2 CAMK2G CAMKK1 CAMKK2 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling EPGN NRAS EGF AREG EGFR HBEGF SOS1 HRAS TGFA EREG BTC DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization CD9 ADAM2 ACR IZUMO3 OVGP1 IZUMO2 IZUMO4 IZUMO1 SPAM1 ZP1 ZP3 ZP2 ZP4 ADAM21 ADAM20 ADAM30 B4GALT1 HVCN1 CATSPER1 CATSPER3 KCNU1 CATSPER2 CATSPERB CATSPER4 CATSPERD CATSPERG DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT GALT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) CYP4A22 PTGR1 GGT1 ALOX15 CYP4F11 ALOX5AP ALOX5 DPEP2 MAPKAPK2 DPEP1 CYP4A11 CYP4B1 LTA4H LTC4S CYP4F22 CYP4F2 GGT5 CYP4F3 CYP4F8 ABCC1 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL1 AURKA FBXL7 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC FBXL18 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 SKP1 ADRM1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex SMARCD1 BCL7C SMARCD2 BCL7B SMARCD3 SMARCA2 ACTL6A SMARCA4 PHF10 SMARCC1 SMARCC2 BRD7 SMARCB1 ARID2 PBRM1 SMARCE1 ACTB BCL7A THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome BCL2 NLRP1 BCL2L1 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland PRL EGF AREG FGF10 TGFA MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease DIS3 SKIC2 SKIC8 HBS1L NT5C3B SKIC3 DCPS EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PTTG1 NEK2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 PSMD12 CCNB1 BUB1B PSMD11 UBB CDC20 PSMD14 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PLK1 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events KIDINS220 NTRK1 MAP2K1 MAP2K2 RAP1A NGF RAPGEF1 MAPK1 FRS2 BRAF CRKL MAPK3 CRK YWHAB SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism SQOR MAT1A TXN2 GOT1 GOT2 GADL1 FMO1 TST CBS ADI1 BHMT2 BHMT AHCY ADO APIP CSAD SUOX MPST MTR CTH SLC25A10 CDO1 MTRR MRI1 ENOPH1 TSTD1 ETHE1 MTAP RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle RHOT2 TRAK1 TRAK2 MYO19 MFN1 MFN2 RAP1GDS1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense CALM1 UBB UBC GBP2 GBP1 RPS27A GBP4 CASP4 CALM3 CALM2 GBP6 UBA52 UBE2D2 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition CDT1 CDC6 MYC DHFR CCND1 CABLES1 WEE1 RBL2 RBL1 PPP2R1A E2F4 CDC7 SKP1 UBA52 AKT2 AKT3 CCNE2 CCNE1 CUL1 PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC POLE PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 PSMA5 SEM1 PSMA6 POLE4 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 POLE2 PRIM2 PSMC3 PSMA1 PRIM1 POLE3 PSMA2 POLA1 PSMC4 POLA2 PSMC1 PSMC2 CKS1B PPP2R3B SKP2 MAX MCM10 DBF4 RPA4 AKT1 RRM2 CDK7 TFDP1 TYMS TFDP2 MNAT1 CDKN1A E2F1 PPP2CA PPP2CB CDC45 MCM7 PPP2R1B MCM8 MCM3 CDKN1B MCM4 MCM5 E2F5 MCM6 MCM2 E2F6 PCNA LIN54 LIN37 LIN9 LIN52 RPA1 RPA2 RPA3 PTK6 CDK4 FBXO5 CDK2 CCNA2 HDAC1 CCNA1 TK1 RBBP4 RB1 CCNH GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) NFYA NCOA1 NFYB NCOA2 SCD MVD SC5D PMVK NFYC MVK NCOA6 GGPS1 MED1 HMGCS1 DHCR7 TBL1XR1 LSS TM7SF2 HELZ2 RXRA FDFT1 ACACB ACACA GPAM SP1 SQLE PPARA TGS1 FDPS CREBBP IDI1 TBL1X SREBF2 SMARCD3 CYP51A1 CHD9 CARM1 MTF1 FASN ELOVL6 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription RB1 ZCRB1 DDX5 VHL MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance APOC4 APOBR APOB VLDLR LSR APOC1 MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase H2AC14 H2BC12L NUP107 NUP188 BANF1 NUP210 NUP93 H4C9 NUP205 LPIN1 POM121 LPIN2 LPIN3 AAAS EMD NUP160 POM121C NUP85 TPR NEK9 NUP88 NEK6 H2AC20 NEK7 NUP155 PPP2R1A H2AX NUP153 VRK1 LEMD2 NUP62 CTDNEP1 H3-3B CNEP1R1 H3C8 LMNB1 NDC1 SEC13 NUP133 NUP50 H2AJ NUP54 CCNB2 H3C15 CCNB1 NUMA1 NUP42 H2BC9 H2BC8 H2BC5 NUP43 H2BC3 H2BC1 RAE1 RANBP2 PLK1 CDK1 NUP35 H2AB1 RAB2A GOLGA2 GORASP2 NUP37 BLZF1 SMC4 H2AC8 SMC2 H2AC6 H2AC7 ARPP19 NCAPH2 NCAPG2 ENSA NCAPD3 NUP214 MASTL MCPH1 PRKCA PPP2R2D SET H2BC26 PPP2CA PPP2CB PPP2R1B H2BC21 LEMD3 H2BC17 MAPK1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RAB1A RAB1B H3-4 KMT5A GORASP1 RB1 H2AC19 USO1 PRKCB H2AZ2 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes EP300 CNOT10 CNOT4 CNOT6 RGCC CNOT7 PLK2 CNOT1 CNOT11 CNOT2 CNOT3 CNOT8 CNOT9 ZNF385A TP53 PRMT1 PCBP4 RBL2 RBL1 PLK3 TFDP1 TFDP2 GADD45A CARM1 E2F4 E2F7 E2F8 CDKN1A ARID3A BTG2 E2F1 BAX TNKS1BP1 CDKN1B CNOT6L PCNA PLAGL1 NPM1 CPAP CCNE2 CCNE1 AURKA CCNB1 CDK2 CCNA2 CCNA1 CDC25C CDK1 SFN CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex MCM8 CDC6 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation ATF1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPKAPK2 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 STAT3 MT-CO2 NLRP3 MT-CO3 ALB MED1 TBL1XR1 TXNIP COX7B HELZ2 RXRA COX7C PPARA TGS1 CREBBP COX8A COX8C FABP1 MAFK CYCS NFE2L2 CHD9 COX5B COX5A CARM1 COX7A2 HBA2 COX7A1 COX6C SIN3A BLVRB NCOA1 NCOA2 BLVRA COX6A1 NCOA6 COX6A2 COX7A2L NCOR2 HMOX1 HMOX2 COX4I1 COX6B2 COX4I2 NCOR1 COX6B1 COXFA4 ABCC1 HM13 STAP2 BACH1 TBL1X HDAC3 PTK6 SMARCD3 MT-CO1 HIGD1C HBB RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle RHOT1 TRAK1 TRAK2 MYO19 RAP1GDS1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation CBFB GLI2 HDAC4 IHH REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function HEYL CTNNB1 TNRC6C JUP MOV10 AGO3 AGO4 SP1 AGO1 AGO2 SNAI1 CDH11 CTNNA1 TNRC6A TNRC6B ANGPTL4 CTNND1 ADAM33 PRDM8 ILF3 FOXF1 BHLHE22 CDH8 HOXC8 ZEB2 ADAM19 CDH24 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity PRDM1 JMY MDM2 PIN1 MDM4 RAD9B SUPT16H RAD9A PRR5 PPP1R13B PDPK1 DYRK2 EXO1 PPP1R13L MLST8 TOPBP1 ZNF385A RFC5 RFC3 RFC4 RFC2 PRKAG2 PIP4P1 PRKAA1 RNF34 AURKB TP53INP1 PPP2R1A RBBP8 PHF20 RFFL MTOR PML RAD50 TAF4B TAF7L CDKN2A UBA52 AKT2 AKT3 TAF9 AURKA TAF1L UBB MBD3 UBC RPS27A TAF9B TAF15 TAF12 GATAD2B TAF13 GATAD2A TAF10 TAF11 SSRP1 TAF8 CDK1 TAF7 TAF6 TAF5 EP300 TAF4 TAF3 TAF2 TAF1 TP53RK NOC2L KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 DNA2 RHNO1 L3MBTL1 AKT1 MEAF6 TP53 MAPKAP1 NUAK1 TP53BP2 ATRIP BANP CDK5 BARD1 PLK3 TPX2 RAD17 STK11 CSNK2A1 ATM ATR CSNK2A2 TP73 CHD4 SETD9 CHD3 PRKAG1 CDK5R1 PPP2R5C MAPK14 CSNK2B BRCA1 PPP2CA MAPK11 PRKAG3 PPP2CB ING5 ING2 PPP2R1B PRMT5 RMI2 BRD1 PRKAA2 RMI1 TOP3A TBP SGK1 WRN RICTOR BRD7 RPA1 RPA2 HIPK1 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 HDAC2 CDK2 PIP4K2A CCNA2 HDAC1 MRE11 CCNA1 PIP4K2B NBN KMT5A PIP4K2C RBBP4 USP7 USP2 BRIP1 PRKAB2 KAT6A MAPKAPK5 BLM RBBP7 SMYD2 MTA2 EHMT2 EHMT1 MAP2K6 BRPF1 BRPF3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion GLP1R PRKACG PRKACB IQGAP1 RAP1A PRKAR1B GNG3 RAPGEF3 PRKAR1A GNG2 RAPGEF4 GNG5 GNG4 GNG7 AKAP5 GNG8 ADCY8 ADCY6 KCNB1 ADCY5 PRKAR2A KCNG2 GNG10 PRKAR2B KCNC2 GNG12 GNAS GNG11 GNG13 GNB2 ITPR1 GNB1 ITPR2 GNB4 ITPR3 GNB3 GNB5 PRKACA GCG GNGT1 GNGT2 KCNS3 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination UBE2Z UBE2N UBE2E3 RRAGA UBE2V2 UBA6 CTR9 UBE2H SKIC8 RTF1 UBE2B RNF152 SHPRH USP5 PEX2 RNF40 RNF144A UCHL3 SELENOS UBE2A PAF1 WAC PRKDC TMEM129 HLTF PEX10 UBE2W PEX12 UBE2D1 PEX13 PEX14 DERL1 RNF181 RAD18 UBE2L3 UBA1 UBE2K RNF20 UBE2C UBE2E1 UBE2Q2 UBE2S USP9X H2BC17 UBE2R2 PCNA H2BC12 H2BC13 H2BC14 H2BC15 UBE2J2 UBA52 UBE2D2 H2BC11 CDC73 UBB LEO1 UBC H2BC9 H2BC8 H2BC5 CDC34 H2BC3 HLA-A RPS27A UBE2D3 USP7 H2BC1 UBE2G1 UBE2G2 BCL10 UBE2T VCP OTULIN RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CBFB RUNX1 LGALS3 CSF2 CREBBP PRKCB DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis CASP8 RIPK1 RIPK3 FADD TRADD MLKL TRAF2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMC3 LAMA3 LAMB3 LAMB1 LAMA2 LAMA4 LAMB2 LAMA1 VTN LAMC2 LAMC1 FN1 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing TYW3 TYW2 TYW1 LCMT2 HSD17B10 EPRS1 TRMT10C NUP107 PRORP ELAC2 NUP188 TRNT1 NUP210 NUP93 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 NUP133 NUP50 NUP54 CLP1 NUP42 NUP43 RAE1 TRMT112 RANBP2 NUP35 RAN NUP37 TP53RK NUP214 CSTF2 QNG1 URM1 POP5 WDR4 POP7 THADA TSEN15 LAGE3 POP1 OSGEP POP4 THG1L RPP30 ALKBH8 RTCB TRMT44 ZBTB8OS TRDMT1 TSEN2 PUS3 TSEN54 TRMT10A RPP38 METTL1 RPP21 NSUN2 RPP25 TPRKB TSEN34 ADAT1 DDX1 NSUN6 RPP14 TRMT1 CDKAL1 C2orf49 PUS7 RTRAF FTSJ1 RPP40 CPSF4 TRIT1 XPOT ADAT3 FAM98B CPSF1 ADAT2 DUS2 TRMT9B QTRT1 GON7 QTRT2 CTU2 CTU1 TRMT6 TRMT13 TRMT11 YRDC TRMT61A TRMU OSGEPL1 MTO1 TRMT61B GTPBP3 TYW5 TRMT5 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly ZDHHC8 A2M PRKACG PRKACA PRKACB APOA1 ABCA1 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency OTC IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis ALDH9A1 SHMT1 TMLHE BBOX1 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects PNP IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A IFIT5 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B SKP1 RPS27L RPS15A RPS3 RPS2 RPS15 RPS14 FAU RPS17 RPS16 RPS19 RPS18 RPS9 RPS7 RPS8 RPS11 CUL1 RPS5 RPS10 RPS13 RPS6 RPS12 RPSA RPS27A RPS4Y2 IFIT1 RPS4Y1 IFIT3 IFIT2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling IRS1 PIK3R2 PIK3CB PIK3R1 FYN FRS2 PIP5K1A PIP5K1B PIP5K1C PIK3CA IER3 MYD88 FLT3LG PDGFB CD19 CD28 IRAK4 STRN FLT3 GAB2 TRAF6 IL33 CD86 KLB CD80 EGF ERBB2 PDGFRB FGF19 EGFR FGFR4 IL1RL1 TRAT1 PIK3AP1 PTPN11 EPGN PPP2R1A PIK3R3 PIK3R6 PIK3R5 IRS2 ESR1 INSR PDGFRA FGF6 AKT1 HGF GAB1 MET AREG LCK SRC FGF7 FGF22 FGF3 FGF10 PPP2R5B NTRK2 BDNF PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E RAC1 NRG1 INS NRG2 EREG BTC MAPK1 NRG3 MAPK3 FGF1 NRG4 FGF4 FGF16 FGF9 FGF18 HBEGF FGF20 PIK3CD FGF23 PIK3CG KIT NTRK3 FGF2 PIP4K2A ESR2 PIP4K2B PIP4K2C TGFA RAC2 NTF3 RHOG IRAK1 VAV1 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes TNFRSF10C AIFM2 CASP10 PMAIP1 TNFRSF10D BID BBC3 NLRC4 TP53I3 BCL6 TNFRSF10B TNFRSF10A CASP1 TP53AIP1 PERP FAS TP63 PPP1R13B TRIAP1 PIDD1 CASP6 CREBBP CASP2 TP53 APAF1 STEAP3 TP53BP2 RABGGTB PRELID3A RABGGTA BIRC5 BNIP3L PRELID1 TMEM219 CRADD IGFBP3 TP53INP1 ATM TP73 NDRG1 BCL2L14 CHM BAX ZNF420 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism SDS SDSL RIDA DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism GPC1 EXT2 GPC3 ST3GAL3 GPC2 GPC5 HEXB NCAN HEXA GPC4 BGN GPC6 VCAN SDC1 B3GALT6 CHST14 CHST3 CSPG5 DCN AGRN FMOD OGN CHSY1 HSPG2 KERA BCAN SLC26A2 LUM OMD B4GALT1 ACAN B4GALT7 SDC4 PRELP SDC2 SDC3 CHST6 PAPSS2 B3GAT3 EXT1 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME SLC22A8 SLCO1A2 ABCG2 ALB SLC22A1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters ERLIN2 CP DERL2 RNF5 OS9 SLC16A1 HK1 RNF185 NUP107 NUP188 NUP210 NUP93 SLC12A3 NUP205 SLC12A1 POM121 SLC26A2 AAAS SLC12A6 NUP160 POM121C NUP85 TPR NUP88 ABCD1 NUP155 NUP153 DERL3 DERL1 NUP62 ABCD4 ABCB4 NDC1 SLC2A9 SEC13 SLC2A1 NUP133 APOA1 SLC2A2 NUP50 ERLEC1 SLC5A5 UBA52 NUP54 ABCA12 ABCB11 ABCA1 SLC6A5 ABCC2 SLC6A2 ABCC8 PSMD12 SLC6A3 PSMD11 UBB NUP42 PSMD14 SLC1A1 SLC2A10 PSMD13 SLC1A3 UBC SLC3A1 PSMA7 NUP43 SLC6A20 PSMB6 RPS27A PSMD8 SLC67A1 RAE1 PSMB7 RANBP2 PSMB4 PSMD6 RHAG PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 SLC6A19 SLC17A8 SLC36A2 NUP35 SLC6A14 ADRM1 PSMA5 SEM1 SLC7A7 PSMA6 PSMA3 SLC7A9 PSMC5 NUP37 PSMA4 SLC24A1 SLC24A4 PSMC6 SLC4A1 PSMC3 PSMA1 SLC4A4 PSMA2 PSMC4 PSMC1 SLC11A2 PSMC2 SLC22A5 BSG SLC3A2 AVPR1B AVPR1A SLC5A7 AVP SLC20A2 SLC39A4 SLCO2A1 NUP214 ABCG8 ABCG5 SLC26A4 KCNJ11 SLC26A3 AVPR2 SLC35A2 SLC35A3 SLC33A1 SLC35C1 ABCC6 ABCC9 SLC29A3 SLC27A4 SEL1L LMBRD1 GCKR GCK SLCO1B1 SLC24A5 SLCO1B3 SLC22A12 CFTR SLC34A3 SLC34A2 SLC34A1 SLC9A6 SLC40A1 SLC9A9 HEPH SLC35A1 ABCB6 VCP SLC5A1 SLC5A2 ABCA3 SLC17A5 ERLIN1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ VEGFA TGFB2 TGFB3 CFD CD109 CLU AHSG PROS1 ITGB3 ALDOA F13A1 PDGFB FGB LAMP2 FGA TGFB1 FGG F5 SERPINE1 F8 PECAM1 EGF SERPING1 PPBP KNG1 STXBP2 ORM1 ORM2 CAP1 FN1 CD36 CALM1 FLNA VCL CFL1 APOOL APOA1 TUBA4A ISLR HABP4 CHID1 GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 ENDOD1 SPARC APOH SOD1 VTI1B MANF CALU MAGED2 FERMT3 ACTN2 ECM1 OLA1 ABCC4 CTSW SERPINA4 TMSB4X TIMP3 ANXA5 TOR4A SPP2 IGF2 LEFTY2 PF4 IGF1 LY6G6F VEGFB VEGFC QSOX1 VEGFD ITGA2B LHFPL2 PCYOX1L POTEKP MMRN1 CD63 FAM3C APLP2 SERPINF2 TMX3 SELENOP SCG3 RARRES2 CYRIB SCCPDH HRG LGALS3BP PRKCG WDR1 PLEK PHACTR2 SRGN PSAP ITIH4 ITIH3 CLEC3B CDC37L1 CYB5R1 CD9 APP ALB A1BG SERPINA3 ACTN4 GAS6 HSPA5 SELP PPIA HGF TF PRKCA A2M STXBP3 STX4 TLN1 PCDH7 RAB27B TIMP1 TTN ACTN1 PFN1 PLG VWF SERPINA1 THBS1 PRKCB BRPF3 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding OGG1 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling VAV2 PSEN2 ARHGEF9 TNFRSF10D APH1A ARHGEF3 APH1B ARHGEF4 NGEF ARHGEF1 TAB3 ARHGEF2 TAB2 ARHGEF7 TAB1 ARHGEF5 MAPK8 ABR ARHGEF6 SORCS3 MYD88 SQSTM1 TRAF6 AATF MAGED1 CASP2 PSENEN YWHAE SMPD3 SMPD2 ARHGEF33 UBE2D1 ARHGEF35 FGD1 ARHGEF37 FGD2 ARHGEF38 RELA FGD3 FGD4 ARHGDIA ARHGEF40 NFKB1 BEX3 TRADD MCF2 TNFRSF10B FASLG ARHGEF26 TNFRSF10A TRAF2 CASP8 TNFSF10 FAS RIPK1 FADD UBA52 CFLAR UBE2D2 TBK1 OPTN ECT2 ARHGEF39 UBB UBC RPS27A UBE2D3 ARHGEF10L MCF2L OBSCN BAG4 ARHGEF11 SPPL2B ARHGEF10 SPPL2A ARHGEF12 CLIP3 ARHGEF15 NSMAF BCL2L11 ARHGEF17 OTULIN ARHGEF16 BAD ARHGEF19 ARHGEF18 TIAM2 LINGO1 MAG ITGB3BP OMG NFKBIA RTN4 GNA13 CHUK RASGRF2 ADAM17 IKBKE IKBKB TNF IKBKG PLEKHG2 RIPK2 ULK1 PSEN1 RACK1 MAPKAPK2 PRKCI NCSTN NGF SOS2 TIAM1 PRDM4 UBE2L3 CASP10 CASP3 PLEKHG5 RAC1 TRAF1 RHOA RNF31 TNFAIP3 XIAP OTUD7B SPATA2 SHARPIN USP4 USP21 STUB1 MIB2 TNFRSF1A CYLD RBCK1 SOS1 OTUD1 MAP3K7 BIRC2 BIRC3 KALRN HDAC2 HDAC3 HDAC1 NET1 NGFR TRIO AKAP13 USP2 ITSN1 TAX1BP1 PREX1 VAV3 IRAK1 VAV1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication MCM8 PPP2R1B CCNB1 PRIM2 PRIM1 POLA1 POLA2 TFDP1 TFDP2 PPP2R3B PPP2R1A RB1 E2F1 ORC5 ORC4 CDK1 PPP2CA ORC6 PPP2CB ORC1 ORC3 ORC2 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression NR1H4 CLOCK NR1H3 G0S2 MED1 ACSL1 MED4 MED6 MED7 THRAP3 CDK19 PEX11A PPARGC1A PPARGC1B CREBBP FAM120B ARNT2 CYP1A1 SREBF2 BMAL1 MED19 MED15 MED18 MED11 MED16 MED17 MED12 MED14 MED13 MED26 MED10 CD36 MED29 MED28 MED22 HMGCS2 NCOA1 NCOA2 MED25 NCOA6 MED21 NCOA3 ABCB4 HMGCS1 APOA2 APOA1 MED27 RGL1 MED23 APOA5 NCOR2 AGT MED24 NCOR1 MED20 AHR PLIN2 UGT1A9 ABCA1 ANGPTL4 ACADM GPS2 TBL1X SLC27A1 RXRB FADS1 EP300 ESRRA CPT1A NRF1 TIAM2 NPAS2 NR1H2 RORA CYP4A11 TBL1XR1 HELZ2 RXRA MED30 SP1 MED31 PPARG PPARA TGS1 FABP1 ALAS1 TXNRD1 CDK8 CHD9 CPT2 CYP7A1 CARM1 TNFRSF21 NFYA NFYB NFYC GRHL1 FDFT1 NR1D1 FHL2 ME1 ARNT HDAC3 SMARCD3 TRIB3 SULT2A1 MTF1 AHRR GLIPR1 MED8 CCNC MED9 ANKRD1 MED13L FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors FFAR1 GPR31 FFAR4 FFAR3 FFAR2 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 BRCA2 RAD51AP1 BRIP1 RBBP8 ATM BLM XRCC2 PALB2 RAD50 BRCA1 RAD51 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle WDR6 FLOT2 FAM83B PIK3R2 RASAL2 DSP PLXNA1 ANKRD26 DST PIK3R1 CAV1 ARHGAP35 PLEKHG5 KIDINS220 TXNL1 ALDH3A2 LEMD3 TMEM59 VANGL1 FRS2 CCDC88A DEPDC1B VANGL2 UBXN11 FRS3 CPD DLG5 FAM135A PKP4 GRB7 RBMX EPHA2 RRAS2 PTPN13 KIF14 TFRC STMN2 RND1 EPSTI1 ARHGAP5 STIP1 MUC13 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome GAB1 EGF PIK3R1 AREG EGFR TGFA EREG PTPN11 BTC EPGN SRC PIK3CA PAG1 HBEGF CSK PXN DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication SUN2 EIF4G2 EIF4E3 ACOT2 EIF4A3 OST4 OSTC UBE2I STT3A KPNA7 KPNA4 KPNA5 STT3B KPNA3 BTF3 KPNA1 SUMO1 HSPA5 DDOST MAGT1 DAD1 IPO7 MAP1LC3B XPO1 VIM HDLBP PDIA3 DPM1 XRN1 DPM2 DPM3 PABPC1 DNAJC10 SEC11A SEC11C DNAJA2 CANX HSPA8 KPNB1 NMT1 EIF4A2 HSPA1A EIF4A1 EIF4G1 PRKG2 HYOU1 RTN3 ATL2 APOA1 SPCS3 SPCS2 SPCS1 NACA RRBP1 EIF4E UBA52 TUSC3 KPNA2 P4HB UBB SCAP UBC TMEM258 CALR DNAJC3 P4HA1 RPS27A P4HA2 P4HA3 YBX1 HSPA1B RPN2 FASN NPLOC4 VCP UFD1 DNAJB11 RPN1 BAG2 EIF4G3 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2K UBE2C UBE2Z UBE2E1 UBE2Q2 UBE2S USP9X UBE2E3 UBE2R2 UBA52 UBE2D2 UBA6 UBB UBC UBE2H UBE2B CDC34 RPS27A USP5 USP7 UBE2G1 UBE2G2 UBE2A UCHL3 UBE2W UBE2T UBE2D1 OTULIN UBE2L3 UBA1 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling STAT3 IRS1 PIK3R2 H3C8 IL7R PIK3R1 IL2RG BRWD1 JAK3 JAK1 HGF H3C15 SMARCA4 CISH IRS2 SOCS2 STAT5A SOCS1 TSLP PIK3R3 STAT5B IL7 RAG2 CRLF2 RAG1 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants FLT3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis TYRP1 DCT TYR OCA2 SLC45A2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation CD8B AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint CCNB2 WEE1 CCNB1 CCNA2 CCNA1 CDK1 PKMYT1 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling CD3G PIK3R2 PIK3CB PIK3R1 UBE2N TAB2 PLCG2 PIK3CA WAS PAK1 PDPK1 TRAF6 PAK3 PLCG1 TRAT1 BTRC UBE2D1 RELA SKP1 FBXW11 NFKB1 GRAP2 LCP2 PAK2 UBA52 UBE2D2 CD4 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC ITK TRAC CDC34 PSMA7 CD3E CD3D PSMB6 RPS27A PSMD8 TRBV12-3 PRKCQ TRAV29DV5 CARD11 PSMB7 TRBV7-9 TRBC1 PSMB4 PSMD6 HLA-DQA2 HLA-DQA1 PSMB5 PSMD7 HLA-DPA1 VASP PSMB2 TRAV19 PSMB3 PSMD2 BCL10 HLA-DRB5 PSMD3 HLA-DRB4 FYB1 PSMB1 PSMD1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 ADRM1 LAT PSMA5 HLA-DQB2 CD101 SEM1 HLA-DRB1 PSMA6 PSMA3 HLA-DQB1 PSMC5 PSMA4 ZAP70 PSMC6 PTPRJ PSMC3 PSMA1 PSMA2 PSMC4 NFKBIA PTPN22 PSMC1 PSMC2 CHUK NCK1 IKBKB IKBKG PTEN RIPK2 MALT1 PTPRC LCK EVL CSK MAP3K7 INPP5D UBE2V1 PAG1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 GTF2F1 GTF2F2 NUP93 NUP205 POM121 POLR2A NUP214 POLR2B NUP42 AAAS POLR2C POLR2D NUP160 POM121C POLR2G NUP85 NUP43 TPR POLR2I NUP88 POLR2J RAE1 RANBP2 NUP155 POLR2E POLR2F NUP153 POLR2H POLR2K POLR2L NUP35 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate CRYL1 XYLB DCXR SORD AKR1A1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 PPP2R1B LYN CDKN2A CDKN1B JAK2 E2F5 CCND3 CCND2 CKS1B CDKN2D PPP2R3B CDKN2C CDKN1C SKP2 E2F2 UBA52 ABL1 CDKN2B CDK6 CCND1 CCNE2 CUL1 CCNE1 UBB PTK6 CDK4 CDK2 UBC CDK7 RBL2 RBL1 RPS27A PPP2R2A TFDP1 TFDP2 MNAT1 PPP2R1A E2F4 RB1 CDKN1A CCNH E2F1 E2F3 PPP2CA SKP1 PPP2CB SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases STAT3 NRAS HIF1A NR3C1 CCND1 AKT1 EGF ERBB2 EGFR CDKN1B LRRK2 ARHGAP35 RAC1 PELP1 NRG1 ARAP1 NRG2 RHOA EREG BTC DOK1 SFPQ NRG3 NRG4 ELMO1 ELMO2 DOCK1 UBA52 CRK HBEGF KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN CBL SOCS3 CCNE1 GPNMB STAP2 PTPN1 SRMS UBB PTK6 CDK4 CDK2 BCAR1 UBC RPS27A HRAS RASA1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template POLE4 POLE2 POLE3 PCNA UBA52 RPA1 UBA7 RPA2 RCHY1 UBE2L6 POLD1 REV1 ISG15 MAD2L2 REV3L RPA3 TRIM25 RFC5 UBB RFC3 RFC4 POLK RFC2 UBC POLE RFC1 RPS27A USP10 PCLAF USP43 SPRTN POLI POLH NPLOC4 VCP UFD1 POLD3 POLD4 POLD2 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions GJC1 GJA10 PANX2 GJD2 PANX1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis GNPDA1 GNPDA2 NUP37 HK2 HK1 PGK1 HK3 PGK2 NUP107 NUP188 ALDOC ALDOB ALDOA NUP210 NUP93 NUP205 POM121 NUP214 AAAS NUP160 POM121C NUP85 TPR PFKL NUP88 NUP155 PFKM PPP2R1A PFKP NUP153 PRKACA ADPGK PPP2R5D GAPDH PFKFB2 GCKR PFKFB1 PPP2CA GCK PFKFB4 PPP2CB PGM2L1 PFKFB3 NUP62 PPP2R1B PRKACG PRKACB NDC1 SEC13 NUP133 BPGM NUP50 NUP54 ENO1 ENO2 ENO3 ENO4 GPI GAPDHS NUP42 HKDC1 NUP43 TPI1 RAE1 RANBP2 PGAM1 PGAM2 NUP35 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT2 TUBB2B TUBB2A TCP1 TUBAL3 CCT6B TUBA3E TUBB6 TUBA4A TUBB3 TUBA3D TUBB1 TUBA3C CCT8 CCT7 CCT5 TUBA4B CCT4 CCT6A TUBA1A TUBB4B TUBB4A TUBA8 TUBA1C TUBA1B CCT3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures COL4A5 COL1A1 COL1A2 BMP1 COL9A1 COL9A3 COL9A2 COL18A1 LAMC2 CTSV CTSS MMP20 ITGB4 LOXL3 LOXL4 CTSL LOXL1 LOXL2 COL10A1 COL27A1 PCOLCE CTSB MMP7 COL2A1 LOX COL4A2 COL4A1 MMP3 COL4A4 COL6A2 MMP9 COL4A3 PXDN COL6A1 COL8A2 COL6A3 MMP13 COL8A1 ITGA6 COL6A6 COL6A5 PLEC COL15A1 CD151 COL11A1 LAMA3 COL11A2 COL24A1 COL3A1 LAMB3 COL5A1 COL5A3 COL7A1 COL5A2 TLL2 TLL1 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 IKBKE UBB UBC RPS27A TICAM1 UBA52 TANK TBK1 OPTN IRF3 TLR3 TRAF3 IRF7 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway HLA-G B2M HLA-E CTSL HLA-H HLA-B CTSV HLA-C LNPEP CTSS HLA-A HLA-F PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis UMPS CAD DHODH DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels P2RX7 ITPR1 ITPR2 P2RX4 ITPR3 P2RX6 P2RX5 TRPC7 STIM1 P2RX3 P2RX2 TRPC6 P2RX1 TRPC3 ORAI2 ORAI1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors P2RY14 LPAR4 P2RY4 GPR17 P2RY10 P2RY6 P2RY11 P2RY2 LPAR6 P2RY1 P2RY12 P2RY13 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste GNAT3 TAS2R50 GRM1 KCNJ2 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B SCNN1G SCNN1D SCNN1B SCNN1A OTOP1 TAS2R30 TAS1R2 TAS1R1 TAS2R31 TAS1R3 SCN1B TAS2R38 TAS2R39 TAS2R20 TAS2R7 TAS2R8 CALHM1 CALHM3 GNG13 GNB1 TRPM5 SCN3A ITPR3 GNB3 SCN2A TRPM4 SCN2B GRM4 TAS2R1 TAS2R10 TAS2R3 TAS2R13 TAS2R5 TAS2R4 TAS2R14 PLCB2 TAS2R16 SCN9A SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant ADAM17 DLL4 NOTCH1 DLL1 ADAM10 JAG2 JAG1 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type MMAB DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis GLB1 NEU1 CTSA MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling LAMA5 LAMC3 HGF LAMA3 MET PTK2 ITGA2 LAMB3 ITGA3 LAMB1 LAMA2 LAMA4 SRC LAMB2 ITGB1 LAMA1 LAMC2 LAMC1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand ACD TINF2 PCNA TERF1 TERF2 WRN POT1 TERF2IP RPA1 RPA2 POLD3 POLD1 FEN1 POLD4 POLD2 DNA2 RPA3 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling EPHB4 EPHB3 RAC1 EFNB2 FYN EFNB1 EFNB3 ARHGEF7 MYL12A SDCBP PAK2 PAK1 GIT1 EPHB6 NCK2 EPHB2 PAK3 EPHB1 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling STAT3 JAK1 IL6ST JAK2 IL6 IL6R TYK2 STAT1 CBL SOCS3 PTPN11 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency OTC SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2 LEFTY1 CRIPTO3 SMAD4 FURIN CFC1 SMAD3 NODAL DAND5 LEFTY2 ACVR1B CRIPTO DRAP1 ACVR1C ACVR2B MAPK1 ACVR2A MAPK3 PCSK6 FOXO3 CER1 GDF1 FOXH1 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation H2AC14 H2BC21 H3-3B H2BC12L DNMT3B H3C8 H2AC8 H2AC6 H2AC7 DNMT3A H2BC17 H2BC12 H2BC13 DNMT1 H2BC14 H2BC15 H2AJ H2BC11 H4C9 H3C15 UHRF1 H2BC9 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX H2AC19 DNMT3L H2BC26 H2AB1 H2AZ2 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism EIF4G2 EIF4E3 MX2 MX1 NUP37 EIF4A3 UBE2N KPNA7 KPNA4 KPNA5 NUP107 KPNA3 NUP188 PIN1 KPNA1 NUP210 UBA7 PPM1B IRF3 UBE2L6 NUP93 ISG15 HERC5 JAK1 NUP205 POM121 USP18 TRIM25 NUP214 ARIH1 BECN1 AAAS PLCG1 RIGI NUP160 POM121C NUP85 TPR NUP88 EIF4E2 NUP155 EIF2AK2 NUP153 KPNB1 EIF4A2 EIF4A1 EIF4G1 NUP62 UBE2E1 NDC1 SEC13 STAT1 NUP133 MAPK3 NUP50 EIF4E NUP54 UBA52 FLNB KPNA2 UBB NUP42 UBC NUP43 RPS27A RAE1 RANBP2 NEDD4 IFIT1 NUP35 EIF4G3 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions SNCB MT1M MT1X MT2A MT1A MT1F MT1G MT1H MT1B MT1E MTF1 MT4 MT3 CSRP1 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) ARRB2 MAPK1 GNA14 GNA13 GNG3 MAPK3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 F2RL2 F2RL3 F2R F2 GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 ARRB1 GNB4 GNB3 GNA12 GNB5 GNGT1 GNGT2 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines SAT1 PAOX ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling CAPZA1 S100B CAPZA2 SAA1 APP MAPK1 AGER S100A12 MAPK3 PRKCSH HMGB1 DDOST LGALS3 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) LUM OMD B4GALT1 PRELP ACAN FMOD OGN KERA INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling STAT3 PIK3R2 SYK INPPL1 PIK3CB IL5 PIK3R1 JAK2 IL2RG STAT1 STAT4 IL21R JAK3 IL2RA IL2RB PIK3CA IL2 PTPN6 PTK2B IL3 HAVCR2 IL5RA LGALS9 PIK3CD SOS1 GAB2 IL21 CSF2RB INPP5D JAK1 SHC1 CSF2RA GRB2 CSF2 LCK IL15RA IL15 IL3RA SOS2 STAT5A PIK3R3 STAT5B IL9 IL9R DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC7A6 SLC7A7 SLC7A5 SLC7A8 SLC7A9 SLC6A12 SLC36A4 SLC3A2 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC38A1 SLC6A19 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP H2BC14 H2BC15 H2AJ H2BC11 H4C9 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 H2BC1 H2AX H2AC19 H2BC26 H2AB1 H2AZ2 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP MBD4 H2BC14 SMUG1 H2BC15 NEIL2 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 H2BC1 TDG H2AX H2AC19 NTHL1 H2BC26 NEIL3 H2AB1 H2AZ2 NEIL1 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t PGM1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters SLC22A8 SLC22A12 SLC22A6 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE ARHGEF19 VAV2 PSEN2 ARHGEF18 ARHGEF9 ARHGEF3 APH1A TIAM2 ARHGEF4 APH1B ARHGEF1 NGEF ARHGEF2 ITGB3BP ARHGEF7 ARHGEF5 MAPK8 ABR ARHGEF6 GNA13 RASGRF2 SQSTM1 TRAF6 AATF CASP2 PSENEN MAGED1 PLEKHG2 PSEN1 YWHAE NGF NCSTN SOS2 TIAM1 ARHGEF33 FGD1 ARHGEF35 FGD2 ARHGEF37 ARHGEF38 FGD3 FGD4 ARHGEF40 CASP3 PLEKHG5 RAC1 BEX3 MCF2 ARHGEF26 UBA52 SOS1 KALRN ECT2 ARHGEF39 UBB UBC NET1 RPS27A NGFR TRIO AKAP13 ITSN1 ARHGEF10L MCF2L PREX1 OBSCN ARHGEF11 VAV3 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 BCL2L11 ARHGEF16 VAV1 BAD RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 ZBP1 IKBKB RIPK3 DHX9 IKBKG NFKB1 NFKB2 NFKBIA TICAM1 RIPK1 MYD88 NFKBIB CHUK NKIRAS1 NKIRAS2 RELA TLR3 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLBD1 PLA2R1 PLA2G3 PLA2G5 PLA2G6 PLA2G2F PLA2G2D PLA2G2E PNPLA8 PLA2G2A TMEM86B MBOAT2 LPCAT4 LPCAT3 LPCAT2 LPCAT1 PLA2G4F PLB1 PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLA2G10 PLA2G1B DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p ALG11 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly RAN TUBB2B TUBB2A NUP37 UBE2I TUBAL3 NUP107 TUBA3E NUP188 TUBA3D RCC1 BANF1 TUBA3C SUMO1 NUP93 CHMP4C CHMP4B CHMP4A SIRT2 NUP205 TNPO1 POM121 EMD NUP160 NUP85 PPP2R2A NUP155 TUBA1A PPP2R1A CHMP2B CHMP2A KPNB1 PPP2CA VRK1 NUP62 LEMD2 LBR LMNB1 NDC1 SEC13 LEMD3 NUP133 TUBB6 TUBA4A TUBB3 TUBB1 RANGAP1 CHMP3 NUP54 CHMP6 CHMP7 TUBA4B VPS4A CCNB2 CCNB1 AHCTF1 NUP43 ANKLE2 TUBB8 SPAST IST1 TUBB8B CC2D1B TUBB4B TUBB4A TUBA8 TUBA1C CDK1 TUBA1B NUP35 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family LYN SYK MUC12 MUC15 FYN MUCL1 MUC3A MUC5AC MUC3B CLEC10A PLCG2 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 CLEC4A MUC19 CLEC4C CLEC4D CLEC4E MUC5B MUC20 MUC21 CLEC6A FCER1G MUC13 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 FGFR2 FGF1 FGF7 FGF4 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 FGF23 FGF6 FGF2 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease FRS2 PIK3CA GAB1 NRAS PIK3R1 PLCG1 FGFR4 SOS1 HRAS GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV GYG1 GYS1 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins SIPA1L1 LRRTM3 LRRTM4 LRRTM1 LRRTM2 HOMER3 DLGAP1 DLGAP3 DLGAP2 DLGAP4 SHANK2 STXBP1 EPB41L1 SHANK1 NRXN1 NLGN3 NLGN1 NLGN2 EPB41 NRXN3 NRXN2 BEGAIN EPB41L5 EPB41L2 PDLIM5 NLGN4Y NLGN4X HOMER1 HOMER2 DBNL SYT7 GRIN1 SYT12 APBA1 APBA3 APBA2 GRIN2A EPB41L3 GRIN2B STX1A SYT9 GRM1 GRM5 SYT10 SHARPIN SHANK3 CASK LIN7A LIN7C GRIN2C GRIN2D DLG2 DLG3 DLG4 SYT1 LIN7B SYT2 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation MASP1 COLEC11 MBL2 FCN1 FCN2 FCN3 COLEC10 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) VAV2 CTSL FARP2 UBB CTNND1 ARHGEF4 UBC RAC1 CBLL1 RPS27A CTSB CTNNB1 CDH1 SRC ELMO1 JUP DOCK1 UBA52 TIAM1 CDC42 CDH11 CTNNA1 CTSS ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IRS2 PIK3CA LYN GAB1 EPO PIK3CB PIK3R1 JAK2 EPOR PIK3CD PIK3R5 PIK3CG FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis VAV2 CD3G FCGR3A SYK FGR HCK FYN NCKAP1L WAS CDC42 ARPC1B ARPC1A MYO9B ACTG1 ABI2 WASL ABI1 IGHV3-23 NCKIPSD IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 BRK1 V1-7 V5-1 ABL1 V1-5 V1-3 IGKV3D-20 NCK1 V5-6 ACTR3 IGLV3-19 IGKV2-30 ACTR2 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 MYH2 V4-6 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 WASF1 WASF2 WASF3 BAIAP2 RAC1 MAPK1 MAPK3 ELMO1 BTK ELMO2 DOCK1 CRK PTK2 CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 YES1 VAV3 IGHG3 IGHG4 IGHG1 ACTB IGHG2 VAV1 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification ST8SIA3 SEC16A CP SEC23IP CNIH1 CNIH2 FOLR1 CNIH3 BET1 HK1 DBT TNIP2 GGCX SPTB KDELR1 ANK2 CTR9 RTF1 SPTBN4 SPTBN5 SEC31A PAF1 DERL1 DPAGT1 MPI DOLK SPTA1 DCTN1 BGLAP DMP1 BPIFB2 GPIHBP1 PSMD12 PSMD11 PSMD14 PSMD13 MATN3 ARF3 ARF1 PSMA7 PSMB6 PSMD8 UBE2D3 TNC PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MPDU1 ADRM1 PSMA5 FBN1 SEM1 SUMF2 PSMA6 SUMF1 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 NUS1 LAMB2 FOXO4 ATXN3 NUP214 PDIA3 DPM1 DPM2 DPM3 FBXO32 IDE HSPA8 RBX1 SRD5A3 ATXN3L JOSD2 JOSD1 L3MBTL2 SLC35A1 TGFA SLC35A4 FKRP B4GAT1 CRPPA ST6GALNAC5 CHST10 DAG1 ST6GALNAC6 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN SATB2 CUL3 ABRAXAS2 MYSM1 KBTBD7 STAMBPL1 C3 STAMBP NUP107 NUP188 NUP210 NUP93 NUP205 POM121 HSP90B1 AAAS NUP160 ARSA POM121C NUP85 RNF152 TPR NUP88 SHPRH PEX2 XRCC4 RNF40 RNF144A NUP155 SELENOS WAC PRKDC TMEM129 HLTF NUP153 PEX10 PEX12 PEX13 UMOD PEX14 ASGR1 ASGR2 RNF181 ARSL RAD18 MANEA ARSJ ARSK ARSH ARSI ST8SIA5 NUP62 ARSF ARSG ARSD ELOB ELOC CTSA NDC1 SEC13 NUP133 RPL27A ZNF350 RANGAP1 NUP50 LGALS1 NUP54 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 MXRA8 SPARCL1 PCGF2 SCG2 STC2 NUP42 AMELX AMBN TMEM132A HRC PRSS23 BMP15 NUP43 MEPE RCN1 ENAM TAF9B AMTN RAE1 FAM20C VWA1 RANBP2 FAM20A ITIH2 AFP GOLM1 TAF10 NUCB1 IGFBP1 NUP35 NUP37 VCAN FUT3 GLB1 ARSB IFIH1 TRAPPC2L RAB32 TRIM25 RAB31 RAB22A TBC1D20 IKBKG RAB40A RAB35 RAB40B RIGI RAB40C RAB3B RAB3C RAB38 RAB42 RAB2B RAB34 PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB29 RAB6B RAB15 RAB19 RAB17 TRAPPC2 AMER1 TRAPPC3 AXIN1 TRAPPC1 TRAPPC4 TRAPPC5 APC RAB39A MVD RAB27A RAB39B RAB27B MAT2B TRAPPC9 INS MBTPS1 RAB8B PARP1 RAB33A RAB33B TRAPPC6A GATA3 TRAPPC6B RAB7B RPL8 RAB1A KCTD6 RAB1B SMAD2 GCSH RAB21 SMAD1 SMAD4 SMAD3 SMURF2 CHML TRAPPC10 SMAD7 RAB11B RAB10 RAB12 RAB13 RAB18 BMP4 CAMKMT THBS1 FDX1 HIF1A MITF MYC PROS1 SERPINA10 FGA TGFB1 FGG CLSPN F2 F5 F7 F8 F9 SERPINC1 PROZ KNG1 F10 SERPIND1 TFAP2B TFAP2C PROC EIF2AK2 TOPORS SEMA5A POMT2 UBE2D1 SPON2 SEMA5B SPON1 RELA THSD7B POMT1 ADAMTSL1 ADAMTS2 C1GALT1C1 ADAMTS3 ADAMTSL5 ADAMTSL4 UBE2C ADAMTSL3 ADAMTSL2 CDKN2A UBE2E1 MUC12 MUC15 THSD7A IL6 UBE2S ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 MUC19 C1GALT1 SSPOP MUC5B MUC20 MUC21 ST6GAL1 DNAJC3 MOGS HLA-A PLAUR RPN2 SAR1B SDC2 PALB2 RPN1 GALNT2 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 EDEM2 ALB OTUB2 OTUD5 OTUD7A VCPIP1 RPS23 ZRANB1 YOD1 TNIP1 RNF128 TNIP3 OTUB1 MAGT1 TRIM4 IKBKE TOMM70 RIPK2 ANO8 FOLR2 CANX RNF135 MGAT5 GPC3 MGAT1 RPS2 MGAT2 VDAC1 ASPH TUSC3 MAP3K7 ADRB2 RPS6 ANK3 TMEM258 VCP DDX5 KDM8 FUT8 OGFOD1 EIF5A JMJD4 DHPS MAN2A1 FN3KRP JMJD7 RCCD1 EIF5A2 DLAT NLRP3 DNAJC24 DPH1 OST4 DPH2 DPH3 DPH5 MAVS OSTC DPH6 STT3A DPH7 UBE2N ZC3H15 B3GNT7 RWDD1 FN3K TAB1 ICMT B3GNT5 DOHH STT3B B3GNT4 RIOX1 DRG1 B3GNT3 ST6GALNAC2 DRG2 B3GNT2 PRKCSH DDOST DAD1 TRAF3 TRAF6 USP14 MAN1B1 ST6GALNAC3 USP18 ST6GALNAC4 BECN1 SEC23A NOD1 CD59 NOD2 GANAB CD55 VHL SEC24B SEC24A GALNT1 MGAT4C MGAT4A ARRB1 MGAT4B SEC24D SEC24C CALM1 NAPA RAB5C TGOLN2 B4GALT2 B4GALT3 DCAF7 TUBB6 PENK TUBB3 TUBB1 POLB FBXO4 FBXO6 FBXW4 FBXW5 GOLGB1 FBXW10 FBXW7 CTSZ FBXW9 FBXW2 B4GALT6 CISH B4GALT4 B4GALT5 SOCS2 FBXL3 SMC5 SMC6 FBXL5 PARK7 DDX17 NSMCE3 NSMCE2 TUBA1C NSMCE1 TUBA1B HIC1 EID3 ZBED1 TP53BP1 SP3 TOP2A TOP2B ZNF131 TUBB2B TUBB2A SENP5 FOXL2 SENP2 APP SAFB RNF168 NSMCE4A NFKB2 TOP1 ARRB2 SP100 UHRF2 CASP8AP2 USP11 NOP58 TUBA3E RWDD3 MBD1 TUBA3D RAD52 TUBA3C SKP2 UBXN1 NGLY1 COP1 MLEC ENGASE B4GALT1 AREG NFE2L2 TMED2 EEF1A1 NOTUM CDH2 EEF2 SEL1L FUCA2 ST3GAL6 LRR1 RAB6A CCNF KEAP1 USP8 UBE2L3 HERC2 FBXO7 FBXO9 WSB1 FBXO2 RNF123 RHOA UBE2J2 SIAH2 EPAS1 FBXL8 SOCS3 FBXL4 FBXL7 GAN UBA2 PRKN SAE1 KLHL2 UBE2G1 KLHL3 UBE2G2 KLHL9 SPSB2 SPSB1 VNN1 VNN2 KBTBD6 KLHL5 UBE2T KBTBD8 SPSB4 FBXO27 CAPZB FBXO21 UBE2Z FBXO22 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 AHSG LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 RAB3D UBE2V2 RAB44 CUL7 CUL5 UBA6 CUL2 KLHL11 RAB37 RAB4B KLHL13 FBXO44 CAPZA1 FBXO41 U2AF2 RAB24 FBXO40 CAPZA2 BTBD1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W COPB1 UBA3 UBA1 UBE2K UBE2M HGS KBTBD13 RAB7A UBE2Q2 UBE2R2 TRAF2 ASB13 ASB14 RIPK1 ASB11 ASB12 UBE2D2 RNF7 ASB17 ASB18 FBXL22 FCGR3B ASB15 FBXL21P PSME2 ASB16 FBXL20 ASB10 FBXL19 FBXL18 CDC34 FBXL15 QSOX1 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 BCL10 ASB5 ASB2 ASB3 ASB1 PSME1 GOLGA2 CDC25A SEC22B NFKBIA MDC1 PSMB10 PSMB8 GRIA1 PSMB9 NSF DAXX RRAGA BARD1 CDKN1A CHM BRCA1 ING2 VGF TGFBR1 TGFBR2 DDB2 PCNA WRN USP17L2 RCE1 NPM1 RPA1 SPTBN2 FGF23 HIPK2 P4HB APOB CDC20 CTSC CCNA2 CCNA1 NFU1 LIPT2 CAPZA3 ACTR10 LIPT1 LIAS PIGS USP7 IGFBP3 CPM LY6K USP2 PIGU PGAP1 PIGT PIGO PSCA BLM GPAA1 PIGN PIGP PIGZ DCTN6 PIGW DCTN5 MSLN DCTN4 PIGV PIGY PIGX PRSS21 PRND TECTA TECTB CD52 TOMM20 RTN4RL2 IZUMO1R PIGC PIGB CEACAM7 VDAC3 NRN1L RTN4RL1 VDAC2 PIGA CEACAM5 CD109 PIGK LY6D PIGM MDM2 SPACA4 PIGL MDM4 PIGG LY6H PIGF GPLD1 PIGH NRN1 NTM TEX101 LYPD1 USP30 LYPD2 SQSTM1 LYPD3 THY1 LYPD4 LYPD5 ART3 ART4 LYPD8 TRIM27 OTOA LY6G6C USP13 TNKS LY6G6D TNKS2 OPCML RABGGTB NTNG1 RNF146 RABGGTA NTNG2 OTUD3 NEGR1 CNTN5 BIRC5 GP2 LSAMP PLET1 PRSS41 UCHL1 AURKB SENP8 XPNPEP2 RAET1G UCHL3 LYPD6B FOXK2 ST6GALNAC1 FOXK1 RAET1L MBD5 ALPL CMAS MBD6 CNTN3 NPL NANP CNTN4 ASXL1 NEU4 MELTF ASXL2 ST8SIA4 ALPG BAP1 MDGA2 NANS PML ST6GAL2 ULBP2 MDGA1 ST8SIA1 RECK GNE SPRN TRRAP H2AC17 H2AC12 JMJD6 TADA2B H2AC25 H2AC21 DLST GALNT11 GALNT14 GALNT13 GALNT16 PRMT3 GALNT15 GALNT18 GALNT17 GALNT10 POFUT4 POFUT2 POFUT3 QTGAL EMID1 B3GALNT2 GALNTL5 GALNTL6 ANK1 GALNT9 GALNT8 POMGNT2 B3GNT9 B3GNT8 KDM1B MMRN1 B3GNT6 MMRN2 CHST4 TUBB8 GCNT1 MGAT5B RUVBL1 GCNT3 TUBB8B GCNT4 TPST2 MAN1A2 GCNT7 TPST1 MAN1C1 GALNT7 MAN1A1 GALNT6 GALNT5 GALNT4 A4GNT H2AC1 POMK RAB2A PIAS4 ATXN7 HDAC4 PIAS3 THRB UBE2I VDR NR1H2 RIOX2 RORA NR3C1 ESR1 NR2C1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 H2BC18 SUMO2 RARA PPARG PGR PPARA USP22 TP53 PTEN ETFB SLC35C1 DCAF13 MUC13 ALG5 NUDT14 ARF4 CKAP4 KTN1 MUL1 ALPI GMPPB ARFGAP1 FPGT GMPPA STS GFUS ALG10 ALG10B FUOM DHRSX GMDS PMM1 FCSK ADAMTS13 DOLPP1 PREB KDELR3 GBF1 GOSR1 RAB11A NEU2 NEU3 RAB41 NEU1 APOE NPLOC4 B4GALNT2 COG8 UFD1 COG7 COG6 COG5 COG4 COG3 COG2 BET1L MRTFA RAB30 GOSR2 RAB36 DYNC1LI1 BST1 DYNC1LI2 LTBP1 CDCA8 APOL1 HIF3A RHOT1 CHRDL1 HNRNPC IGFBP7 WFS1 PNPLA2 UCHL5 USP15 NEDD8 DYNLL2 CETN2 LRRC41 FSTL1 FSTL3 CCP110 INCENP ACTR1A TUBA1A UBXN7 GPS1 BTRC PDIA6 DPP3 RAB8A LMAN1 SKP1 NDUFAB1 STX5 YKT6 FBXW11 CSNK1D USP9X BRCC3 BABAM1 BABAM2 SMC3 DYNLL1 UIMC1 RAD21 ABRAXAS1 STAG1 STAG2 SMC1A UBA52 NRIP1 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA UBB NFRKB UBC ACTR5 RPS27A RAD23A ACTR8 RAD23B DDB1 DYNC1H1 INO80C INO80B INO80E INO80D TUBB4B COPS7B TUBB4A COPS7A XPC CDK1 TFPT OTULIN INO80 CUL4A COPS3 COPS6 COPS5 COPS8 CUL4B PCSK9 COPS4 COPS2 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 ADAM10 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 COMMD9 PUM2 DDA1 USP33 ANKRD9 COMMD2 ARFGAP3 ETF1 COMMD3 COMMD1 ARFGAP2 COMMD6 COMMD7 ADAMTS16 COMMD4 COMMD5 SPSB3 CCDC8 ADAMTS18 CUL9 UBD USP10 NAE1 SOCS6 WDTC1 SOCS5 CCDC22 COMMD10 DTL TULP4 DCAF16 LAMC1 DCAF17 CAND1 FEM1C ADAMTS4 DCAF10 ADAMTS5 DCAF11 FEM1A FEM1B RNF20 NEURL2 ERCC8 ADAMTS1 TIMP1 ADAMTS8 ADAMTS9 ST3GAL5 CGA RAB43 CFTR KDELR2 COPB2 COPA COPE TMED3 TMED7 SCFD1 TMED9 COPZ2 COPZ1 SPTBN1 FURIN STAM ARF5 SPP1 LAMB1 COL7A1 ARCN1 COPG2 COPG1 RAB3A SPTAN1 METTL21A KIN METTL22 H2AC19 EEF2KMT ETFBKMT VCPKMT SLC17A5 EEF1AKMT2 ACTB EEF1AKMT1 EDEM3 H2AC14 EDEM1 TRIM28 AMFR SYVN1 DERL2 RNF5 RNF103 RNF139 OS9 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 HCFC1 PSMD9 PSMD4 PSMD5 PPARGC1A PAAF1 PSME3 PSME4 CREBBP PSMD10 DYNC1I1 PSMB11 IL33 H4C9 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 USP17L4 USP17L5 USP17L8 RAB9A H2AC20 USP5 USP3 RAB4A USP17L30 RAB9B FKBP8 SNX3 USP37 USP34 USP47 USP48 USP49 USP42 RAB5A USP44 PTRH2 USP16 USP12 MFGE8 WDR20 USP17L21 USP17L20 FN1 USP17L22 CST3 USP19 USP24 NCOA1 USP17L15 NCOA2 USP25 USP17L18 USP26 USP17L17 USP20 USP17L19 ACTL6A USP17L10 USP17L12 APOA2 USP28 USP17L3 STAM2 APOA1 USP17L11 LY6E USP17L13 USP17L1 NCOR2 APOA5 KAT2B KAT2A C4A CALU ALG8 ALG9 ALG6 ALG2 ALG3 ALG1 SPP2 SUZ12 H2BC9 RAB14 H2BC8 CALR H2BC5 MCRS1 H2BC3 H2BC1 APLP2 SCG3 DHDDS EP300 MEN1 SENP1 H2AC8 H2AC6 H2AC7 TFG CTBP1 HNRNPK DNMT1 LHB WDR48 GAS6 SUDS3 TF BMI1 RAB5B CBX5 YY1 RING1 SKIC8 TADA3 SATB1 RNF2 OGT HDAC7 CBX8 CHD3 PHC2 COG1 PHC1 H2BC26 CBX4 CBX2 SIN3A H2BC21 MIA2 PHC3 MIA3 DNMT3B NAGK WDR5 GFPT2 AMDHD2 GFPT1 TMEM115 PGM3 GNPNAT1 UAP1 DNMT3A RENBP H2BC17 TNFAIP3 H2BC12 OTUD7B H2BC13 H2BC14 H2BC15 USP4 ALG14 ALG13 USP21 ALG12 ALG11 H2BC11 CYLD BIRC2 BIRC3 TTLL10 CDC73 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 HDAC2 AXIN2 NICN1 VASH2 VASH1 TTLL7 LEO1 AGBL5 HDAC1 AGBL4 TTLL6 TTLL5 RFT1 TTLL4 MTA1 AGBL1 TTLL3 MCFD2 TTLL2 SERPINA1 TTLL1 PPP6C RBBP5 PPP6R1 TDG AGBL3 PPP6R3 AGBL2 LMAN1L TTLL13 GORASP1 TTLL11 SEC22A TTLL12 TTLL9 SEC22C TTLL8 NAPB TMED10 RBBP7 LMAN2L STX17 CSF1 USO1 MAN2A2 NAPG MGAT3 ST8SIA6 LMAN2 CHST8 SEC31B FUCA1 PMM2 ANKRD28 ST8SIA2 SEC16B REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation ING2 EP300 BRD1 PIN1 BRD7 AKT2 AKT3 MEAF6 AKT1 HDAC2 TP53 MBD3 HDAC1 PIP4K2A PIP4P1 PIP4K2B RBBP4 PIP4K2C GATAD2B KAT6A GATAD2A RBBP7 CHD4 MTA2 CHD3 PML MAP2K6 BRPF1 ING5 BRPF3 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway CASP3 TICAM2 TRADD LY96 TNFRSF10B FASLG TNFRSF10A TRAF2 TICAM1 CASP8 TNFSF10 FAS RIPK1 UNC5A CD14 UNC5B FADD DCC TLR4 MAGED1 DAPK1 DAPK2 DAPK3 APPL1 CASP9 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS IRS2 CRKL SHC1 LYN EPO NRAS JAK2 EPOR SOS1 HRAS RAPGEF1 VAV1 PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair TXN PCMT1 MSRA MSRB3 MSRB1 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 AMN CUBN CBLIF BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency ACAT1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation CALM1 PPP2R1B PPP2R5E NRAS PHB1 JAK2 MAP2K1 MAP2K2 BRAF PPP1CC MAP3K11 KSR1 YWHAB RAF1 BRAP SHOC2 MRAS MARK3 PPP1CB ARAF SRC PPP2R1A CAMK2B CAMK2D CAMK2A PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA HRAS CAMK2G PPP2CB SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors S100A9 APOB PRDX1 SAA1 HMGB1 SSC5D CD5L APOA1 CD36 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors APOB STAB2 STAB1 SPARC ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR IZUMO3 IZUMO2 IZUMO4 IZUMO1 CD9 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders PSMA5 ERLIN2 SEM1 PSMA6 PSMA3 DERL2 PSMC5 PSMA4 RNF5 PSMC6 OS9 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 RNF185 PSMC2 ABCG8 ABCG5 KCNJ11 ABCD1 ABCC6 ABCC9 SEL1L LMBRD1 DERL3 DERL1 ABCD4 ABCB4 APOA1 ERLEC1 UBA52 CFTR ABCA12 ABCB11 ABCA1 ABCC2 ABCC8 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 ABCB6 PSMD3 VCP PSMB1 PSMD1 ABCA3 ADRM1 ERLIN1 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) TLR6 LY96 TIRAP TLR1 S100A1 S100A9 BTK CD14 S100A8 MYD88 TLR2 HMGB1 TLR4 IRAK4 FGB FGA FGG CD36 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 S100A1 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 FGB FGA PELI1 LRRC14 FGG TRAF6 USP14 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 TLR1 PPP2R1A S100A9 S100A8 TLR2 BTRC RELA SKP1 CD36 FBXW11 NFKB1 LY96 TRAF2 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT SOCS1 DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 SIGIRR IRAK3 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TIRAP PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 TLR6 FOS MAP2K1 MAPK1 MAPK3 BTK MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes CBFB CTSL RUNX1 CTSK SOCS4 CTSV SOCS3 SERPINB13 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer EP300 MEN1 MYC CCNK CCNT2 CCNT1 SKIL SP1 TGIF1 TGIF2 SERPINE1 JUNB NEDD4L RNF111 CDK8 RBL1 TFDP1 TFDP2 COL1A2 E2F4 CDK9 UBE2D1 PPM1A SNW1 E2F5 USP9X MAPK1 NCOR2 PARP1 MAPK3 UBA52 NCOR1 TRIM33 CDKN2B ATP1B4 SKI SMAD2 UBB FURIN SMAD4 SMAD3 HDAC1 SMURF2 UBC SMAD7 RPS27A UBE2D3 YBX1 WWTR1 CCNC CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation KICS2 RPL24 RPL27 RPL26 RPL29 SEH1L RPL28 WDR59 RHEB MIOS WDR24 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A MLST8 DDIT3 CEBPG FNIP1 FNIP2 ITFG2 KPTN CEBPB SZT2 MTOR EIF2S3 FLCN EIF2S2 RPL10 EIF2S1 RPL12 RPL11 RPL14 ATP6V1H RPL13 RPL15 ATF3 RPL18 RPL17 RPL19 SEC13 RPL27A RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPLP1 RPLP0 RPS27A RPS4Y2 RPLP2 RPL18A RPL36AL RPS4Y1 ASNS RPS26 ATP6V1E1 RPS25 ATP6V1E2 RPS28 ATP6V1G1 RPS27 ATF2 ATP6V0E1 RPS29 ATP6V1G2 RPL7A RPS20 RPS21 RPS24 RPS23 RRAGA RRAGC RRAGB ATP6V0D1 RPL37A RRAGD ATP6V0D2 ATP6V1A RPL36A RPL35A RPL22L1 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPS27L RPTOR RPS15A RPS3 SAMTOR NPRL2 NPRL3 TCIRG1 RPS2 EIF2AK4 ATP6V0B ATP6V1B2 ATP6V0C RPL26L1 ATP6V1B1 FAU RPL4 CASTOR1 RPL5 RPL30 CASTOR2 RPL3 RPL32 SESN1 RPL31 RPL34 RPS9 RPL9P9 RPS7 IMPACT RPL8 RPS8 SH3BP4 RPS5 RPL6 LAMTOR2 RPL7 LAMTOR1 RPS6 ATP6V0E2 LAMTOR4 ATP6V1G3 LAMTOR3 RPL36 RPSA LAMTOR5 RPL35 SESN2 TRIB3 RPL39L RPL38 RPL37 RPL39 ATF4 DEPDC5 RPL21 RPL23 SLC38A9 RPL22 GCN1 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling ATF1 ELK1 RPS6KA3 RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 MAP3K8 DUSP6 MAP2K3 DUSP7 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 MAPK9 TAB1 ATF2 MAPK8 MAP2K7 MAPK10 TNIP2 CHUK TRAF6 IKBKB IKBKG RIPK2 NOD1 NOD2 MAPKAPK2 IL17RC PPP2R1A IL17RA BTRC PPP2R5D IL17RE MAPK14 SKP1 IL17RB PPP2CA JUN MAPK11 PPP2CB PPP2R1B MAPK7 FBXW11 NFKB1 FOS MAP2K1 MAPK1 MAPK3 IL17F UBA52 IL17A MAP3K7 CUL1 UBB IL25 UBC RPS27A UBE2V1 IL17C MAP2K6 IRAK1 IRAK2 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination HIF1A MYC RHOT1 TNIP2 TGFB1 CLSPN UCHL5 USP15 NEDD8 CCP110 UBE2D1 HGS BRCC3 USP9X BABAM1 BABAM2 UIMC1 TRAF2 ABRAXAS1 RIPK1 UBA52 PSMD12 PSMD11 UBB PSMD14 NFRKB PSMD13 UBC PSMA7 ACTR5 PSMB6 RPS27A RAD23A PSMD8 ACTR8 PSMB7 PSMB4 RAD23B PSMD6 PSMB5 INO80C PSMD7 INO80B PSMB2 INO80E PSMB3 INO80D PSMD2 PSMD3 PSMB1 PSMD1 CDK1 TFPT ADRM1 INO80 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 CDC25A PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 NFKBIA PSMC2 OTUB2 OTUD5 OTUD7A VCPIP1 ZRANB1 YOD1 TNIP1 RNF128 FOXO4 TNIP3 OTUB1 ATXN3 TRIM4 TOMM70 USP33 RIPK2 BARD1 USP10 IDE BRCA1 RNF135 TGFBR1 TGFBR2 DDB2 VDAC1 ATXN3L JOSD2 JOSD1 USP17L2 CFTR RCE1 MAP3K7 ADRB2 CDC20 STAM CCNA2 CCNA1 USP7 USP2 VCP H2AC19 ACTB H2AC14 NLRP3 TOMM20 MAVS ABRAXAS2 MYSM1 VDAC3 STAMBPL1 VDAC2 STAMBP TAB1 MDM2 HCFC1 MDM4 USP30 TRAF3 TRAF6 USP14 IL33 USP18 BECN1 USP13 TNKS NOD1 TNKS2 RNF146 NOD2 USP17L4 OTUD3 USP17L5 USP17L8 H2AC20 USP5 USP3 USP17L30 UCHL1 FKBP8 SENP8 SNX3 UCHL3 USP37 ARRB1 FOXK2 USP34 FOXK1 MBD5 USP47 MBD6 USP48 USP49 ASXL1 USP42 ASXL2 BAP1 USP44 PTRH2 USP16 USP12 WDR20 USP17L21 TRRAP USP17L20 H2AC17 USP17L22 H2AC12 USP19 USP24 USP17L15 USP25 USP17L18 USP26 USP17L17 USP20 USP17L19 ACTL6A USP17L10 USP17L12 USP28 USP17L3 STAM2 USP17L11 TADA2B USP17L13 H2AC25 USP17L1 H2AC21 POLB KAT2B KAT2A H2BC9 H2BC8 H2BC5 MCRS1 H2BC3 TAF9B H2BC1 KDM1B RUVBL1 TAF10 H2AC1 EP300 ATXN7 H2AC8 H2AC6 H2AC7 ARRB2 USP11 ESR1 SKP2 AR WDR48 H2BC18 IFIH1 SUDS3 USP22 TP53 TRIM25 IKBKG YY1 PTEN RIGI TADA3 OGT AXIN1 H2BC26 KEAP1 USP8 APC H2BC21 MAT2B RNF123 RHOA H2BC17 TNFAIP3 H2BC12 OTUD7B H2BC13 H2BC14 H2BC15 USP4 USP21 CYLD H2BC11 SIAH2 GATA3 MUL1 BIRC2 BIRC3 AXIN2 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 PRKN SMAD7 UFD1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 SKP2 PTTG1 AURKB ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 AURKA PSMD12 PSMD11 UBB CDC20 PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 RB1 PSMB3 PLK1 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events GNAT3 GNAI3 GNA14 GNA15 GNA11 AHCYL1 PRKCD PRKCA CAMKK1 CAMKK2 GNAI1 GNAI2 PRKX PLCB3 PRKACA PLCB4 PLCB1 PLCB2 PDE1C GRK2 CALM1 PRKACG PRKACB MAPK1 ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 KPNA2 ADCY2 CAMK4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A PRKAR2B GNAL NBEA GNAQ ITPR1 PLA2G4A ITPR2 CAMK2B ITPR3 CAMK2D CAMK2A PRKCG CAMK2G PDE1B PDE1A TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA TNPO1 DIS3 XRN1 MAPKAPK2 DCP2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A ZFP36 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction CALM1 CALD1 CAV3 MYL6 VCL MYL9 ANXA1 TRIM72 DYSF PDE5A LMOD1 PAK2 ALDH2 ANXA2 PAK1 ITGB5 CACNA1G MYH11 PXN CACNA1I MYL12B MYL11 ITGA1 MYL5 MYL7 MYL10 MYL6B ANXA6 TPM4 MYL12A TPM3 SORBS1 SORBS3 MYLK GUCY1A2 TPM2 CACNA1H GUCY1A1 TPM1 GUCY1B2 GUCY1B1 TLN1 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling H2AC14 GNAT3 ELK1 H2BC12L PIK3R2 NRAS PIK3R1 CAV1 GNAI3 MED1 MYC PRKCZ CCNT1 HSP90AB1 PIK3CA TNRC6C MOV10 AGO3 AGO4 AGO1 PDPK1 GPAM AGO2 GTF2F1 GTF2F2 TNRC6A STRN TNRC6B CREBBP CCND1 CBFB H4C9 RUNX1 NOS3 EGF EGFR H2AC20 UHMK1 GNAI1 GNAI2 EPGN H2AX CDK9 PIK3R3 PPID HSP90AA1 CALM1 H3-3B NCOA1 NCOA2 H3C8 NCOA3 PPP5C FOXA1 SMC3 FKBP4 RAD21 JUND GREB1 STAG1 STAG2 CXCL12 KAT2B SMC1A H2AJ TFF3 TFF1 NR5A2 KANK1 CXXC5 NRIP1 GTF2A1 USF2 GTF2A2 USF1 ZNF217 AKT2 FOSB AKT3 EBAG9 H3C15 POLR2A POLR2B GNG10 POLR2C POLR2D H2BC9 H2BC8 GNG12 POLR2G H2BC5 GNG11 GNG13 POLR2I H2BC3 GNB2 POLR2J H2BC1 GNB1 GNB4 GNB3 IGF1R GNB5 GNGT1 H2AB1 GNGT2 EP300 ZDHHC7 BCL2 CAV2 SPHK1 H2AC8 H2AC6 H2AC7 ATF2 ESR1 KAT5 GNG3 GNG2 GNG5 GNG4 FOXO3 SP1 GNG7 GNG8 PGR S1PR3 KDM4B XPO1 AKT1 PRMT1 YY1 AREG FKBP5 ZDHHC21 CARM1 SRC SRF AXIN1 JUN POU2F1 H2BC26 MYB H2BC21 CDKN1B KDM1A PTGES3 TBP FOS CTSD EREG MMP7 H2BC17 BTC CITED1 MAPK1 H2BC12 MMP2 H2BC13 MMP3 H2BC14 MAPK3 H2BC15 MMP9 H2BC11 HBEGF KPNA2 GATA3 TLE3 KCTD6 PTK2 HDAC1 ESR2 TGFA POLR2E POLR2F POLR2H DDX5 H2AC19 POLR2K POLR2L HRAS H2AZ2 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 GAB1 NRAS PIK3R1 PLCG1 PTPN11 FRS2 PIK3CA FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF2 GSD II%REACTOME%R-HSA-5357609.5 GSD II GAA GYG1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism IDO1 SLC7A5 HAAO ACMSD KYAT3 TDO2 AFMID KYAT1 SLC36A4 SLC3A2 KMO KYNU AADAT IDO2 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus NUP62 RAN NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 NUP54 NUP210 NUP93 XPO1 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 HSPA1A SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants VCL NRAS ARRB2 MAP2K1 IQGAP1 MAP2K2 RAP1A MAPK1 BRAF MAPK3 ITGB3 APBB1IP KSR1 KSR2 YWHAB FGB FGA RAF1 FGG RAP1B VWF MARK3 ITGA2B ARAF CNKSR2 SRC CNKSR1 ARRB1 PEBP1 CSK HRAS TLN1 FN1 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling IL1F10 IL1RL2 MAPK8 IL1RAPL1 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling ARNT2 HSP90AB1 AHRR ARNT PTGES3 AIP AHR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination CSTF2 CSTF1 NUDT21 SLBP ZNF473 NCBP1 NCBP2 CSTF2T PABPN1 PCF11 WDR33 CLP1 CPSF4 CPSF1 CPSF3 PAPOLA CPSF2 SNRPD3 CPSF7 LSM10 LSM11 SNRPG FIP1L1 SYMPK SNRPE SNRPF SNRPB CSTF3 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels NEDD4L TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 SRI TRPV3 CALM1 TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 UBA52 WWP1 UBB UBC RPS27A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 STOM SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A RAF1 TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 ANO8 ANO9 CLCA1 ANO6 ASIC2 ANO7 ASIC3 ANO4 CLCA4 ANO5 ANO2 ASIC1 ANO3 ANO1 WNK1 WNK2 WNK3 ANO10 RYR1 RYR2 RYR3 UNC80 CLIC2 TSC22D3 SGK1 TRDN ASPH SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND SLC17A3 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions ITGA1 SEMA7A PLXND1 SEMA3E PLXNA1 TREM2 PLXNA2 SEMA4A CD72 SEMA4D TYROBP PTPRC PLXNB3 SEMA5A ITGB1 PLXNA4 PLXNC1 SEMA6A SEMA6D OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TDG TET3 TET2 TET1 CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis PNMT DBH DDC TH REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) PSMA5 SEM1 PSMA6 PSMA3 PSMC5 AZIN1 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 OAZ1 OAZ2 OAZ3 ODC1 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA LINGO1 MCF2 MAG OMG NGFR RHOA RTN4 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle GAD1 GAD2 VAMP2 ARL6IP5 NAAA SLC5A7 DNAJC5 GLS2 APBA1 SNAP25 STX1A GLS HSPA8 SLC18A3 SLC22A2 SLC22A1 SLC17A7 SLC6A12 CHAT SLC6A11 SLC32A1 SLC6A13 ABAT SLC6A1 ALDH5A1 TSPOAP1 MAOA CASK LIN7A SLC1A1 LIN7C SLC1A2 SLC1A3 SLC1A6 SLC1A7 UNC13B RAB3A SLC38A2 SYT1 SYN3 SYN2 CPLX1 SYN1 RIMS1 PPFIA1 PPFIA4 LIN7B SLC18A2 PPFIA3 PPFIA2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation ERCC3 RRN3 UBTF ERCC2 ERCC6 TBP KAT2B KAT2A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 MBD3 HDAC1 CDK7 TAF1D MTA1 TAF1B RBBP4 TAF1C GTF2H1 GTF2H2 MNAT1 GTF2H3 TAF1A GTF2H4 POLR2E GTF2H5 POLR2F GATAD2B GATAD2A POLR2H RBBP7 CCNH CHD4 MTA2 EHMT2 CHD3 MTA3 POLR2K POLR2L TTF1 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion FASTKD2 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 HSD17B10 RCC1L NGRN MRM1 MRM2 MRM3 MTERF3 TRMT10C TFB1M PRORP ELAC2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide RHAG CA1 AQP1 CA2 CA4 SLC4A1 HBA2 HBB NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling CASP2 CASP3 YWHAE BEX3 NGFR NGF DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants FLT3 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair ERCC3 ERCC2 ERCC6 RAD51B MAPK8 RAD51C UBE2V2 CLSPN CETN2 UBE2B GPS1 PHF6 DCAF8L1 DCAF8L2 BRCC3 PPP5C BABAM1 BABAM2 UIMC1 ABRAXAS1 RNF8 APBB1 EYA2 EYA3 EYA4 UBA52 RNF4 RCHY1 OGG1 CENPS PSMD12 PSMD11 UBB PSMD14 POLK NFRKB PSMD13 UBC POLE RFC1 PARP2 PSMA7 ACTR5 MUS81 USP45 BRCA2 PSMB6 RPS27A RAD23A PSMD8 LIG3 RAD51AP1 SLX4 ACTR8 PSMB7 EME1 CHD1L PSMB4 XAB2 EME2 RAD23B PSMD6 DDB1 FIRRM FIGNL1 PSMB5 INO80C PSMD7 GEN1 INO80B PSMB2 SLX1B INO80E XRCC2 PSMB3 INO80D PSMD2 XPA XRCC3 PSMD3 COPS7B PALB2 COPS7A PSMB1 SPIDR PSMD1 XPC POLD3 TFPT POLD4 POLD2 ADRM1 XRCC1 UVSSA INO80 PSMA5 SEM1 CUL4A PSMA6 POLE4 PSMA3 COPS3 PSMC5 COPS6 PSMA4 COPS5 PSMC6 ERCC4 POLE2 PSMC3 ERCC1 PSMA1 POLE3 PSMA2 ERCC5 PSMC4 COPS8 AQR PSMC1 CUL4B MDC1 PSMC2 COPS4 COPS2 KAT5 CHEK2 PRPF19 CHEK1 HUS1 POLD1 DNA2 RHNO1 ATRIP BARD1 RAD17 USP10 PCLAF ATM USP43 SPRTN ATR DTL NTHL1 BRCA1 ERCC8 RMI2 RMI1 TOP3A DDB2 RAD51D PCNA RBX1 WRN PMS2 ALKBH3 RPA1 RPA2 ASCC1 MLH1 KPNA2 RPA3 RAD1 CCNA2 MRE11 CCNA1 NBN MPG USP7 MSH2 FANCD2 BLM POLI POLH CCNH VCP H2AC19 FANCI ACTB H2AC14 FANCC H2BC12L UBE2N ACD TINF2 TERF1 TERF2 POT1 TERF2IP MGMT RAD9B PAXIP1 RAD9A LIG1 LIG4 EXO1 REV1 MAD2L2 REV3L ASCC2 H4C9 ASCC3 TOPBP1 RFC5 RFC3 RFC4 SMARCA5 RNF111 RFC2 ALKBH2 H2AC20 XRCC6 XRCC4 XRCC5 RBBP8 PRKDC H2AX BAP1 RAD50 RAD18 FEN1 ELL ZNF830 ACTL6A MSH6 BAZ1B MSH3 PARG POLQ PNKP ISY1 POLB MBD4 SMUG1 NEIL2 H2AJ APEX1 ADPRS POLR2A POLR2B NSD2 POLR2C POLR2D H2BC9 H2BC8 H2BC5 POLR2G MCRS1 H2BC3 POLR2I H2BC1 POLR2J GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 RUVBL1 PPIE TCEA1 H2AB1 TP53BP1 PIAS4 H2AC8 PIAS3 RNF168 H2AC6 H2AC7 UBE2I DCLRE1C RIF1 POLL RTEL1 NHEJ1 FTO POLM ALKBH5 TDP2 TDP1 PIAS1 RAD52 WDR48 UBXN1 SUMO1 SUMO3 UBA7 SUMO2 UBE2L6 ABL1 ISG15 KDM4A KDM4B TP53 TRIM25 YY1 CDK7 SIRT6 MNAT1 NEIL3 H2BC26 NEIL1 RAD51 H2BC21 HERC2 PPP4R2 TIPIN TIMELESS PPP4C H2BC17 H2BC12 H2BC13 PARP1 H2BC14 H2BC15 H2BC11 CDK2 DCLRE1B DCLRE1A FAAP24 H3-4 FAAP20 USP1 FAAP100 POLN CENPX EYA1 FANCM TDG BRIP1 FANCL FANCA FANCB POLR2E FANCE POLR2F FANCG FANCF POLR2H NPLOC4 UBE2T FAN1 UFD1 POLR2K POLR2L H2AZ2 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB ETV6 KANK1 GOLGA4 BIN2 KDR SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 PSEN2 APH1A NRAS PIK3R1 APH1B TAB2 ESR1 GABRQ PIK3CA GABRA1 PGR GFAP PSENEN ADAM17 EGF S100B PSEN1 EGFR NCSTN WWOX SRC STAT5A MXD4 CSN2 STMN1 ADAP1 NRG1 NRG2 EREG BTC NRG3 NRG4 CXCL12 UBA52 NCOR1 HBEGF SPARC SOS1 GABRG3 WWP1 GABRG2 SHC1 UBB UBC ITCH RPS27A GABRB3 GABRB2 GABRB1 DLG4 APOE NEDD4 HRAS YAP1 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GAD1 GAD2 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism ST3GAL2 SUMF2 SUMF1 ST3GAL3 HEXB HEXA GLB1L3 FUT2 GLB1L2 B3GNT5 FUT1 GLB1L GM2A GLB1 UGCG ARSB ARSA SMPD3 GALC SMPD2 A4GALT SMPD4 M6PR SMPD1 GLA GAL3ST1 ARSL ARSJ ASAH1 ARSK ASAH2 ARSH ARSI ST8SIA5 ARSF ARSG ARSD CTSA GBA1 ENPP7 B3GALT4 ST3GAL5 UGT8 CERK STS B3GALNT1 B4GALT6 NEU2 B4GALT5 NEU3 ST6GALNAC5 GBA3 ST6GALNAC6 NEU1 B4GALNT1 GBA2 PSAP PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death DFFB DFFA HMGB2 MAPK8 IRF1 IRF2 ADD1 CLSPN MAGED1 DBNL GSN STK24 STK26 GAS2 MAPT YWHAE DYNLL2 YWHAG HSP90AA1 CDKN2A TICAM2 TRADD LMNB1 LY96 TNFRSF10B FASLG DYNLL1 TNFRSF10A TRAF2 TICAM1 CASP8 TNFSF10 PAK2 FAS RIPK1 CD14 FADD UBA52 TLR4 AKT2 AKT3 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BCL2L11 ADRM1 SFN BAD PSMA5 STAT3 SEM1 BCL2 PSMA6 PMAIP1 PSMA3 BMF BID PSMC5 BBC3 RIPK3 PSMA4 PSMC6 BCL2L1 PSMC3 PSMA1 PSMA2 MLKL PSMC4 PSMC1 GSDME PSMC2 CTNNB1 CDH1 TP63 GZMB YWHAB AKT1 PRKCD TP53BP2 YWHAZ DSG2 ELANE TP73 KPNB1 CASP3 OPA1 PKP1 TJP1 MAPK1 DSG3 MAPK3 STUB1 PLEC PTK2 ITCH DAPK1 DAPK2 DAPK3 APPL1 C1QBP AVEN GSDMD DIABLO SPTAN1 CARD8 CASP9 CASP7 BAK1 UNC5A UNC5B KPNA1 YWHAQ DCC HMGB1 YWHAH PPP1R13B PELI1 CHMP4C CASP6 CHMP4B DNM1L CHMP4A BCAP31 APAF1 IL18 CASP5 IL1A CASP4 IL1B TJP2 SDCBP CHMP2B CHMP2A NMT1 BAX FNTA PDCD6IP CHMP3 PPP3CC CHMP6 CHMP7 FLOT1 PPP3R1 ARHGAP10 CASP1 ACIN1 UACA BMX VIM TP53 CYCS APIP SATB1 TFDP1 TFDP2 OGT E2F1 ROCK1 UBE2L3 APC FLOT2 CDC37 DSP H1-1 H1-0 H1-3 H1-2 H1-5 OCLN H1-4 XIAP DSG1 BIRC2 BIRC3 PRKN OMA1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB HADHA HADH ACADL ECHS1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins CYP1A1 ALOX15 LTA4H CYP1A2 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling LYN PRKCA FYN LCK PTPN6 SOCS6 YES1 SOCS1 SOS1 KIT SH2B3 SH2B2 CBL SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CASP3 DIABLO APAF1 CASP9 CYCS CASP7 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 MYC PSMC1 PSMC2 CKS1B SKP2 MAX CCND1 CABLES1 AKT1 WEE1 CDK7 RBL2 TFDP1 TFDP2 MNAT1 E2F4 CDKN1A E2F1 SKP1 CDKN1B E2F5 LIN54 LIN37 LIN9 LIN52 UBA52 AKT2 AKT3 CCNE2 CCNE1 CUL1 PSMD12 PSMD11 UBB PTK6 CDK4 PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RBBP4 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 RB1 PSMB3 PSMD2 CCNH PSMD3 PSMB1 PSMD1 ADRM1 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G PSMA5 SEM1 PSMA6 ELOB PSMA3 PSMC5 PSMA4 ELOC PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL5 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors OXTR OXT AVPR1B AVPR2 AVPR1A AVP DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CEL LIPF PNLIPRP1 PNLIPRP3 PNLIPRP2 CLPS PNLIP DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species SOD3 NOX4 CCS CYBB CYBA TXN2 PRDX3 PRDX6 NOX5 TXN GPX2 GPX1 ERO1A GSTP1 SOD2 SOD1 ATOX1 ATP7A GPX3 GPX6 CAT GPX5 GPX8 NUDT2 GPX7 P4HB PRDX2 NCF1 PRDX1 NCF2 TXNRD1 CYCS NCF4 TXNRD2 AQP8 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex MCM7 CDT1 MCM8 CDC6 POLE4 MCM3 MCM4 MCM5 POLE2 MCM6 PRIM2 MCM2 PRIM1 POLE3 POLA1 POLA2 MCM10 DBF4 RPA1 RPA4 RPA2 RPA3 CDK2 POLE CDC7 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 CDC45 ORC2 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants STAT3 PIK3CA PIK3R2 NRAS PIK3CB PIK3R1 SOS1 PDGFRA STAT1 HRAS EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes ELANE NOTCH2NLA NOTCH2NLC NOTCH2NLB PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly MTTP APOC4 P4HB APOB APOC3 PRKACG PRKACB APOA2 APOA1 APOC2 APOA4 ZDHHC8 A2M APOE SAR1B PRKACA ABCA1 APOC1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA CSTF2 CSTF1 NUDT21 SLBP ZNF473 NCBP1 NCBP2 CSTF2T PABPN1 PCF11 WDR33 CLP1 CPSF4 CPSF1 CPSF3 PAPOLA CPSF2 SNRPD3 CPSF7 LSM10 LSM11 SNRPG FIP1L1 SYMPK SNRPE SNRPF SNRPB CSTF3 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL PLA2G4A HADHB HADHA LCLAT1 PLA2G6 TAFAZZIN HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation ABCC2 FABP1 BLVRB UGT1A4 SLCO1B1 BLVRA SLCO1B3 UGT1A1 ALB GSTA1 HMOX1 HMOX2 ABCG2 ABCC1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones FDX2 POMC HSD17B12 HSD17B11 CYP21A2 SRD5A2 SRD5A1 SRD5A3 TSPOAP1 LHB CGA AKR1B1 CYP11A1 HSD11B1 HSD11B2 STS FDXR HSD3B2 STARD3NL CYP11B2 HSD3B1 CYP11B1 HSD17B3 SERPINA6 CYP17A1 STAR STARD3 AKR1B15 HSD17B1 STARD4 HSD17B2 TSPO STARD6 HSD17B14 CYP19A1 FDX1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 NRAS ANOS1 PIK3R1 FGFRL1 MKNK1 SPRY2 MAPK1 BRAF FRS2 MAPK3 PIK3CA FGF1 FRS3 FGF4 UBA52 FGF9 FGF18 FGF20 SOS1 FGF23 CBL FGF6 FGF2 GAB1 UBB PLCG1 TGFBR3 UBC GIPC1 RPS27A PTPN11 PPP2R1A FGF22 FGF3 FGF10 SPRED2 SPRED1 FLRT2 PPP2CA FLRT3 HRAS PPP2CB FLRT1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER CUL4A ERCC3 POLE4 ERCC4 ERCC2 POLE2 ERCC1 ERCC6 POLE3 ERCC5 AQR CUL4B PRPF19 POLD1 RFC5 RFC3 RFC4 RFC2 CDK7 MNAT1 ERCC8 ZNF830 RBX1 PCNA ISY1 UBA52 RPA1 RPA2 RPA3 POLR2A UBB POLR2B POLK POLR2C POLR2D POLE UBC RFC1 POLR2G POLR2I RPS27A USP7 POLR2J GTF2H1 GTF2H2 GTF2H3 XAB2 DDB1 GTF2H4 POLR2E GTF2H5 POLR2F POLR2H XPA CCNH PPIE POLR2K POLD3 POLR2L POLD4 TCEA1 POLD2 UVSSA SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants ALK STAT3 IRS1 WDCP PIK3R2 PIK3CB ZAP70 PIK3R1 TFG MYH9 MAPK9 MAPK8 ICOS FRS2 BCL11A MDM2 LMO7 PIK3CA DNMT1 PTPN6 TNRC6C ZC3HC1 MOV10 FOXM1 AGO3 GZMB AGO4 AGO1 AGO2 IL10RA PPM1B CARS1 EIF2AK3 BIRC6 SQSTM1 STRN TP53 PRF1 GCC2 JUNB MCL1 PLCG1 CLTC TYK2 EEF1G IRF4 TPR SEC31A ATIC CEBPB STAT5A CDKN1A SKP1 JUN FN1 PPFIBP1 VCL HIP1 KIF5B TWIST1 STAT1 RBX1 BCL2A1 MAPK1 DCTN1 MAPK3 IL10 PRKAR1A RRBP1 FRS3 RNF213 UBA52 NPM1 MSN KLC1 CUL1 CCNB1 RPS6 UBB HDAC1 UBC GRB2 IL22 RPS27A TPM4 RANBP2 TPM3 RB1 EML4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels KCNJ2 KCNJ3 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 GNG4 KCNJ10 GNG7 GNG8 KCNJ12 KCNJ9 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A4 SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 ABCA3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation TCF7L2 CCNB1 CDKN2A HINT1 MET TCF7 CDK2 HDAC1 CDC25B LEF1 CTNNB1 TBX2 PLK1 CDKN1A TCF7L1 CCND1 SIN3A ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport SEC16A CAPZB GOSR2 SEC23IP DYNC1LI1 CNIH1 DYNC1LI2 CNIH2 FOLR1 CNIH3 BET1 SPTB DYNC1I1 F5 KDELR1 CAPZA1 F8 SEC23A CAPZA2 ANK2 CD59 CD55 DYNLL2 SEC24B SEC24A SPTBN4 SPTBN5 ACTR1A SEC31A SEC24D SEC24C COPB1 LMAN1 NAPA STX5 YKT6 CSNK1D SPTA1 SEC13 DYNLL1 DCTN1 GOLGB1 CTSZ DYNC1I2 DCTN2 DCTN3 ARF3 ANK1 ARF1 DYNC1H1 SAR1B GOLGA2 TFG SEC22B GRIA1 NSF TRAPPC2L TBC1D20 AREG ARFGAP3 ARFGAP2 TMED2 TRAPPC2 TRAPPC3 TRAPPC1 COG1 TRAPPC4 TRAPPC5 MIA2 MIA3 TRAPPC9 ARF4 TMEM115 INS KDELR2 COPB2 TRAPPC6A COPA SPTBN2 COPE TRAPPC6B ARFGAP1 TMED3 TMED7 SCFD1 TMED9 RAB1A COPZ2 RAB1B SPTBN1 COPZ1 CTSC ARF5 ANK3 PREB KDELR3 TRAPPC10 CAPZA3 GBF1 ACTR10 TGFA MCFD2 SERPINA1 GOSR1 PPP6C PPP6R1 COL7A1 PPP6R3 ARCN1 LMAN1L COPG2 GORASP1 COPG1 SEC22A SEC22C SPTAN1 NAPB TMED10 COG8 LMAN2L COG7 DCTN6 STX17 COG6 DCTN5 USO1 COG5 DCTN4 NAPG COG4 LMAN2 COG3 SEC31B COG2 ANKRD28 SEC16B BET1L PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA H2AC14 JARID2 EPOP H2BC21 H3-3B H2BC12L DNMT3B H3C8 H2AC8 H2AC6 H2AC7 EED DNMT3A H2BC17 H2BC12 H2BC13 DNMT1 H2BC14 H2BC15 H2AJ H2BC11 AEBP2 MTF2 H4C9 H3C15 SUZ12 EZHIP H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 H2AC20 H2BC1 EZH1 PHF19 EZH2 H2AX PHF1 RBBP7 H2AC19 H2BC26 H2AB1 H2AZ2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth RPS6KA5 NRAS NCAN FYN PTPRA SPTB COL4A5 SPTBN4 SPTBN5 COL9A1 COL9A3 COL9A2 CACNB1 ST8SIA4 CACNB4 SPTA1 MAPK1 COL4A2 COL4A1 COL4A4 MAPK3 COL6A2 COL4A3 AGRN COL6A1 COL6A3 SOS1 SPTBN2 CACNA1G COL6A6 CACNA1I NRTN COL6A5 NCAM1 CACNA1S PRNP PSPN GFRA2 SPTBN1 GFRA4 ARTN PTK2 CNTN2 CACNB2 CACNA1D CACNB3 CACNA1C GFRA1 SPTAN1 GDNF CACNA1H HRAS ST8SIA2 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site CANX CALR ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels ABCC9 ABCC8 KCNJ11 KCNJ8 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP5 DUSP2 JAK1 DUSP1 DUSP16 DUSP8 DUSP10 DUSP4 DUSP9 JAK2 DUSP6 IL6 DUSP7 MAP2K1 TYK2 MAP2K2 PTPN11 PEA15 MAPK1 MAPK3 IL6R CDK1 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors RXFP1 RXFP2 RXFP3 RLN2 RLN3 INSL3 RXFP4 INSL5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex ERCC3 ERCC2 CCNK CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 SUPT4H1 CDK7 CTR9 SKIC8 RTF1 MNAT1 PAF1 ELOA2 SUPT5H CDK9 ELL ELOA NELFB ELOB NELFCD NELFA ELOC NELFE NCBP1 NCBP2 CTDP1 EAF1 CDC73 EAF2 POLR2A POLR2B POLR2C POLR2D LEO1 POLR2G POLR2I POLR2J GTF2H1 SUPT6H GTF2H2 GTF2H3 GTF2H4 POLR2E GTF2H5 AFF4 POLR2F POLR2H CCNH SSRP1 POLR2K POLR2L MLLT1 MLLT3 TCEA1 IWS1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis ACSF3 HACD1 HSD17B12 SCD ACSL6 TECRL ACSL5 ELOVL5 ACSBG1 HACD3 ACSL1 HACD2 ACSBG2 HACD4 TECR ACACA PPT1 OLAH PPT2 MORC2 SCD5 HSD17B3 HTD2 HSD17B8 ELOVL1 FASN ELOVL4 ELOVL2 ACLY CBR4 ELOVL3 SLC27A3 ACSL4 SLC27A2 ACSL3 ELOVL6 ELOVL7 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC19A3 TPK1 SLC19A2 THTPA SLC25A19 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA2 GRIA3 GRIA4 GRIA1 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends H2BC12L PIAS4 RNF168 UBE2I UBE2N MDC1 KAT5 CHEK1 RAD9B RAD9A HUS1 SUMO2 UBE2V2 EXO1 DNA2 RHNO1 CLSPN H4C9 TOPBP1 RFC5 RFC3 RFC4 RFC2 ATRIP BARD1 SIRT6 RAD17 RBBP8 ATM H2AX ATR RAD50 BRCA1 H2BC26 H2BC21 HERC2 RMI2 RMI1 PPP4R2 TOP3A BRCC3 TIPIN BABAM1 TIMELESS BABAM2 PPP4C UIMC1 H2BC17 ABRAXAS1 RNF8 WRN H2BC12 H2BC13 H2BC14 H2BC15 UBA52 RPA1 H2BC11 RNF4 RPA2 RPA3 RAD1 UBB NSD2 CDK2 CCNA2 MRE11 CCNA1 UBC H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 RPS27A H2BC1 BRIP1 BLM TP53BP1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors PTGER3 OXER1 PTGDR LTB4R PTGFR PTGIR PTGER1 LTB4R2 GPR17 PTGDR2 TBXA2R PTGER4 CYSLTR1 CYSLTR2 PTGER2 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy TOMM20 TOMM22 MAP1LC3A ATG9A ATG12 VDAC3 UBE2N VDAC2 TOMM40 ATG5 PINK1 MTERF3 TOMM7 VDAC1 TOMM5 TOMM6 UBA52 UBE2D2 TBK1 OPTN MFN1 MFN2 SQSTM1 MAP1LC3B TOMM70 UBB UBC PRKN RPS27A UBE2D3 UBE2V1 UBE2L3 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization FLT1 VEGFA VEGFB VEGFC FLT4 VEGFD KDR PGF DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells EGF AREG TGFA NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency NAGS WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 AP2S1 FZD5 CLTC CLTB WNT5A CLTA ROR1 AP2A1 ROR2 AP2B1 AP2A2 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E INPP5E ARL13B PDE6D DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) GOSR2 EDEM1 ASNS SYVN1 CXCL8 TSPYL2 DDX11 SSR1 GSK3A EXTL2 SULT1A3 HSPA5 CUL7 EXTL3 WFS1 EIF2AK3 TPP1 ATP6V0D1 CCL2 ADD1 KHSRP DDIT3 WIPI1 DIS3 CTDSP2 HSP90B1 ATF6 CEBPG DNAJB9 DCP2 PARN EXOSC7 SEC31A SERP1 EXOSC6 EXOSC5 EXOSC4 EXOSC9 CEBPB EXOSC8 TATDN2 EXOSC3 EXOSC2 PPP2R5B PDIA6 EXOSC1 PDIA5 KLHDC3 EIF2S3 SRPRA TLN1 SRPRB ATF6B EIF2S2 EIF2S1 NFYA HYOU1 NFYB NFYC ATF3 GFPT1 ACADVL LMNA MBTPS1 DCTN1 EXTL1 MBTPS2 ARFGAP1 SHC1 CXXC1 PREB CALR DNAJC3 CREB3 KDELR3 DCSTAMP CREB3L3 CREB3L4 PLA2G4B CREB3L1 FKBP14 CREB3L2 HERPUD1 ZBTB17 CREBRF MYDGF ATF4 YIF1A IGFBP1 HDGF ERN1 DNAJB11 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state PSMA5 CUL3 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 IHH PSMC3 PSMA1 PSMA2 ARRB2 PSMC4 PSMC1 PSMC2 ULK3 DZIP1 SPOPL ARRB1 SPOP GRK2 GLI1 GLI3 SHH GLI2 SUFU KIF7 RBX1 SMO GPR161 NUMB UBA52 CDC73 KIF3A HHIP PSMD12 CSNK1A1 BOC PSMD11 UBB PTCH1 GAS1 CDON PSMD14 PSMD13 SMURF2 UBC SMURF1 ITCH PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 EVC2 IQCE PSMB3 EFCAB7 PSMD2 PSMD3 EVC DHH PSMB1 DRC4 PSMD1 ADRM1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 GNE NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways NUP62 NUP37 NDC1 SEC13 MLKL KPNA7 KPNA4 NUP133 KPNA5 NUP107 KPNA3 NUP188 PABPN1 NUP50 KPNA1 NUP54 NUP210 KPNA2 CPSF4 NUP93 ISG15 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR GBP1 NUP88 RAE1 RANBP2 NUP155 EIF2AK2 NUP153 KPNB1 NUP35 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle CCT2 CUL3 STK38 RNF20 CDC37 TMOD3 TXNL1 PDE5A COPS4 DBN1 SRRM1 ACTN1 COPS2 HSP90AB1 MYO6 DDX39B TRA2B SPEN HNRNPC RBMX TWF1 CCT7 CPSF7 VIM MSI2 CCT6A ROCK2 GPS1 ACTG1 PHIP ROCK1 RHOBTB1 RBBP6 RHOBTB2 HSP90AA1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) SNAP25 STX1B STX1A DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK4 KCNK10 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 MAN1B1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway POLE4 POLE2 POLE3 PCNA PARG POLB PARP1 APEX1 ADPRS LIG1 RPA1 RPA2 POLD1 RPA3 RFC5 RFC3 RFC4 RFC2 POLE RFC1 PARP2 POLD3 FEN1 POLD4 POLD2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant F8 F9 F10 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation MCM8 CCNB1 ORC5 ORC4 CDK1 ORC6 ORC1 ORC3 ORC2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA1 CHRNA7 CHRNB2 CHRNA9 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRNA5 CHRNA4 CHRNA6 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT STAT3 PIK3R2 LYN PTPRU NRAS PIK3R1 JAK2 GRAP2 RAC1 FYN TEC STAT1 FER PIK3CA PTPN6 CHEK1 MMP9 GRB10 GRB7 SOS1 SH2B3 KIT SH2B2 GAB2 CBL PRKCA LCK CMA1 FES PTPN11 SOCS6 STAT5A SOCS1 YES1 PIK3R3 STAT5B HRAS GRAP VAV1 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC1 APOBEC2 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC3C RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor GRIN1 CALM1 LRRC7 NRAS GRIN2D DLG2 DLG3 GRIN2B DLG4 CAMK2B RASGRF1 CAMK2D DLG1 CAMK2A RASGRF2 HRAS CAMK2G NEFL ACTN2 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription REST SRF KCNIP3 NR3C1 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type GPC1 GPC3 GPC2 GPC5 NCAN GPC4 BGN GPC6 VCAN B4GALT7 SDC1 SDC4 CSPG5 DCN AGRN SDC2 SDC3 HSPG2 BCAN INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling STAT3 JAK1 SHC1 IL2RG GRB2 IL15RA IL15 SOS2 JAK3 IL2RB STAT5A STAT5B SOS1 GAB2 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins MRTFA TRIM28 CDCA8 MITF NUP107 MDM2 NUP188 NUP210 HNRNPC PPARGC1A NUP93 CREBBP H4C9 NUP205 POM121 TRIM27 AAAS NUP160 POM121C VHL NUP85 CETN2 TPR BIRC5 NUP88 TFAP2B TFAP2C XRCC4 INCENP NUP155 AURKB EIF2AK2 TOPORS NUP153 PML RELA NUP62 NCOA1 NCOA2 CDKN2A NDC1 SEC13 SMC3 NUP133 RAD21 ZNF350 STAG1 NCOR2 STAG2 RANGAP1 SMC1A NUP50 NUP54 NRIP1 PCGF2 AURKA NUP42 SUZ12 NUP43 RAE1 RANBP2 SMC5 SMC6 PARK7 DDX17 NSMCE3 NSMCE2 XPC NSMCE1 HIC1 NUP35 EID3 ZBED1 TP53BP1 EP300 SP3 TOP2A TOP2B ZNF131 NUP37 PIAS4 FOXL2 HDAC4 PIAS3 SAFB THRB RNF168 UBE2I NSMCE4A VDR NFKB2 TOP1 SP100 NR1H2 RORA NFKBIA UHRF2 MDC1 NR3C1 CASP8AP2 CTBP1 ESR1 NOP58 NR2C1 NR3C2 MBD1 PIAS1 RAD52 DNMT1 HNRNPK NR5A1 NR4A2 AR RXRA DAXX SUMO1 SUMO3 SUMO2 RARA PPARG PGR PPARA IKBKE TP53 NUP214 BMI1 CBX5 IKBKG RING1 SATB1 RNF2 HDAC7 CBX8 PHC2 CHD3 PHC1 BRCA1 CBX4 CBX2 SIN3A ING2 PHC3 DNMT3B HERC2 DNMT3A PCNA WRN PARP1 NPM1 RPA1 HIPK2 HDAC2 HDAC1 L3MBTL2 MTA1 TDG BLM DDX5 SATB2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes IKBKB UBB RIPK2 UBC PRKCI NGFR RPS27A NGF MYD88 UBA52 IRAK1 SQSTM1 TRAF6 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol RPL24 RPL27 RPL26 RPL29 RPL28 RPL10L RPL10A RPS4X RPL41 RPS3A RPL3L RPL23A RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 CSNK1D RPL17 RPL19 CSNK1E SNU13 RPL27A RPL13A RPS15 RPS14 EXOSC10 RPS17 UBA52 LTV1 RPS16 C1D RRP1 RPS19 FTSJ3 MPHOSPH6 EBNA1BP2 RPS18 ISG20L2 ERI1 LAS1L NOL12 RBM28 RPS11 RIOK2 XRN2 RIOK1 TEX10 RPS10 SENP3 RPS13 GNL3 NIP7 RPS12 NOL9 PES1 RIOK3 WDR18 WDR12 RPLP1 BYSL RPLP0 BOP1 RPS27A TSR1 TRMT112 RPS4Y2 RPLP2 NCL RPL18A RPL36AL RPS4Y1 MTREX RPS26 RPS25 RPS28 RPS27 RPS29 NOP58 RPL7A RPS20 RPS21 RPS24 DDX49 RPS23 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL RPL37A BUD23 UTP14A UTP14C NOP56 UTP15 WDR36 UTP11 IMP3 RPL36A DIMT1 DIS3 WDR75 IMP4 DDX52 UTP18 RPL35A DKC1 NHP2 UTP25 HEATR1 RPL22L1 TSR3 NOC4L NOL6 RRP7A EXOSC7 EMG1 EXOSC6 PDCD11 EXOSC5 EXOSC4 BMS1 GAR1 EXOSC9 DHX37 EXOSC8 RRP36 EXOSC3 UTP20 EXOSC2 EXOSC1 DCAF13 UTP6 NOP14 UTP4 RPS27L UTP3 PNO1 KRR1 RCL1 RPS15A TBL3 MPHOSPH10 NOL11 RPS3 NOP10 RPS2 PELP1 RPP30 RPP38 RPP21 RPP25 RPL26L1 FAU RPL4 RPL5 RPP14 RPL30 RPL3 RPL32 RPP40 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 NOP2 RPL7 RPS6 RPL36 RPSA RPL35 DDX21 RPL39L RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u DPM1 DPM2 DPM3 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling PLCG1 NTRK1 NGF REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression REST NPAS4 NR3C1 SRF TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A KCNIP3 TNRC6B CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) IDH3B ACAT1 IDH3A SIRT3 SDHAF2 SDHAF3 DLD SDHAF1 FH SUCLG2 SUCLG1 SDHAF4 SDHC SUCLA2 SDHD SDHA CSKMT SDHB DLST MDH2 ACO2 OGDH IDH3G CS LYRM4 TRAP1 ISCA2 IDH2 ISCA1 KGD4 NNT FXN GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis B3GALNT1 ST8SIA5 ST3GAL2 ST3GAL3 FUT2 FUT1 B3GNT5 B4GALT6 B3GALT4 B4GALT5 A4GALT ST6GALNAC5 ST3GAL5 ST6GALNAC6 B4GALNT1 UGCG UGT8 GAL3ST1 CERK FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants UBB FLT3LG UBA52 UBC FLT3 RPS27A CBL DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 CYP4F22 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation CALM1 AKT1 NOS3 CAV1 NOSTRIN CYGB SPR ZDHHC21 CYB5B DNM2 DDAH1 LYPLA1 WASL NMT1 NOSIP NMT2 HSP90AA1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation IRAG2 ADGRG3 GGH ADA2 CXCL1 MS4A3 TNFAIP6 CHI3L1 HK3 PTX3 FRMPD3 TOLLIP AHSG PLEKHO2 GRN TMEM179B DOCK2 RAB3D CXCR1 PDXK PGLYRP1 RAB44 LAMP1 NFASC PRSS3 LAMP2 CXCR2 CAMP KCMF1 UBR4 ILF2 RAB37 RAB4B FCAR FGL2 SLC11A1 RAB24 CPPED1 PPBP CALML5 MGAM RNASE3 KRT1 BPI TRPM2 PRTN3 VAT1 S100A9 ORM1 S100A8 ORM2 TLR2 CSTB S100A7 CHIT1 SVIP CD33 QPCT LTF COTL1 CAP1 COPB1 CLEC12A VCL TMEM30A RAB7A SCAMP1 DDX3X RNASE2 TICAM2 FLG2 CNN2 DEFA1B IQGAP1 DYNLT1 AZU1 HRNR DEFA4 PIGR TMC6 SERPINB10 SERPINB12 CD14 ANXA2 LYZ LRG1 MIF HP OLFM4 CYB5R3 PTPRB BIN2 FCGR3B PRCP LCN2 VPS35L CEACAM6 PSMD12 PSMD11 CEACAM8 PSMD14 PSMD13 SURF4 PRG2 PRG3 CYSTM1 QSOX1 CD53 CD63 PSMB7 PGRMC1 CREG1 PSMD6 CD58 HSPA1B CD68 PSMD7 CLEC5A MPO OSTF1 PSMD2 CD93 PSMD3 ATAD3B PGAM1 PSMB1 PSMD1 DOK3 TARM1 PSMA5 MVP PDAP1 S100P ABCA13 NHLRC3 UNC13D PSMC3 ITGAX A1BG PSMA2 CRACR2A PRDX4 S100A11 PSMC2 PA2G4 SERPINA3 SERPINB3 NFAM1 TMT1A AGA ERP44 SLCO4C1 GHDC DNAJC5 EPX CLEC4C CLEC4D PRKCD BRI3 FABP5 HVCN1 CD300A KCNAB2 MNDA FOLR3 CDK13 ITGAL PTPRN2 SERPINB1 SIGLEC14 STK11IP HSPA8 KPNB1 MAPK14 CEACAM3 HSPA1A DNASE1L1 DPP7 DNAJC13 CRISP3 HEBP2 CMTM6 PKP1 RAP1A MAPK1 SLC15A4 SLC2A5 DSC1 LGALS3 ACTR1B LAMTOR2 CTSH LAMTOR1 NDUFC2 LAMTOR3 CTSC ACTR10 ITGB2 GSDMD NRAS CFD C3 LTA4H CAT RETN HSPA6 APAF1 CEACAM1 FRK ARSA C3AR1 XRCC6 XRCC5 APEH CTSA PADI2 TNFRSF1B GSTP1 IST1 ACLY SLC27A2 LRRC7 ACAA1 HEXB GLB1 GUSB ARSB TBC1D10C HPSE PPIA ARG1 RAB31 SNAP25 ALAD PGM2 CPNE1 CR1 CPNE3 AP2A2 PGM1 DGAT1 TRAPPC1 ROCK1 CSNK2B DSP RAB27A PLD1 CKAP4 GDI2 DSG1 PLAC8 SLC44A2 LPCAT1 CYFIP1 RAB10 RAB18 NEU1 AGPAT2 DYNC1LI1 BST1 IQGAP2 PRDX6 NCKAP1L PTPN6 JUP CD177 ITGAV ARHGAP9 DBNL GSN GAA APRT PECAM1 ALOX5 ORMDL3 CEP290 ASAH1 HSP90AA1 TUBB NFKB1 AOC1 DYNLL1 AGL CFP P2RX1 MME B2M GOLGA7 GYG1 HLA-H HLA-B STK10 DNAJC3 HLA-C FPR2 DYNC1H1 PLAUR SERPINB6 TUBB4B PLAU DEGS1 PSAP PAFAH1B2 ATP8A1 PTPRJ ARPC5 GM2A PTAFR ATP11B ATP11A NPC2 CAPN1 PRSS2 SNAP23 FCN1 MAGT1 ADAM10 COMMD9 ADAM8 ACTR2 COMMD3 PSEN1 ANO6 PFKL IMPDH1 NCSTN IMPDH2 ATP6V1D GALNS ELANE ATP6V0A1 GLA CDA ATP8B4 ARMC8 CTSS CAND1 MMP25 TIMP2 TCIRG1 CTSG GNS CTSD CTSB STING1 ATP6V0C MMP8 HMOX2 MMP9 MGST1 TCN1 CD44 DSN1 GPI PYGB PYGL FAF2 SIGLEC9 STBD1 RAB3A SPTAN1 GLIPR1 LILRA3 VCP RHOG RHOF LAIR1 MANBA NME2 LILRB2 FGR LILRB3 FPR1 AMPD3 FCGR2A SIGLEC5 OSCAR S100A12 HSP90AB1 ALDOC ALDOA HMGB1 C5AR1 DDOST SELL CD59 CD55 RAB9B SDCBP PKM FTH1 GPR84 ALDH3B1 VAMP8 CD36 CST3 FTL RAB5C CHRNB4 CYBB CYBA MAN2B1 TSPAN14 ARHGAP45 TYROBP TXNDC5 AP1M1 SLC2A3 IGF2R NAPRT TTR CTSZ ANPEP ATP6AP2 BST2 RAB14 VAPA CD47 DIAPH1 SIRPA PNP PPIE SIRPB1 CCT2 ADGRE5 ADGRE3 PYCARD MOSPD2 ITGAM STOM MLEC DERA CCT8 RAP1B RAB5B B4GALT1 PTPRC EEF1A1 EEF2 GMFG MCEMP1 FUCA2 OLR1 RAB6A YPEL5 TOM1 ARL8A NIT2 PTGES2 ACP3 SNAP29 RAC1 RNASET2 TMBIM1 CANT1 RHOA ATG7 C6orf120 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 NBEAL2 HGSNAT HUWE1 FCER1G SERPINA1 IDH1 RAP2C RAP2B VNN1 CAB39 GCA HBB SRP14 ENPP4 FUCA1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 FFAR1 GNA15 PLCB3 GNA11 PLCB1 PLCB2 GNAQ APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 NEK2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 PSMD12 BUB1B PSMD11 UBB CDC20 PSMD14 CCNA2 PSMD13 CCNA1 UBC BUB3 MAD2L1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 FGF1 FGF4 FGF16 FGF9 PLCG1 FGF18 FGF20 FGF23 FGF2 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJB2 GJB1 GJC1 GJC2 GJA3 GJA10 GJA5 GJA1 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants FLT3 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN ZBP1 DTX4 TBK1 IRF3 NLRP4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus PSEN2 APH1A NEURL1B APH1B CNTN1 MDK MIB2 UBA52 ADAM10 PSENEN UBB PSEN1 UBC DLL1 RPS27A NCSTN JAG1 DLL4 NOTCH2 NEURL1 MIB1 NOTCH2NLA JAG2 NOTCH2NLC NOTCH2NLB DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea KCNMB1 KCNMA1 MYH9 CLIC5 EPB41L1 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A TMC2 MYO3B MYO3A KCNQ4 GSN FSCN2 EZR TWF2 PCDH15 USH1C ESPNL EPB41L3 OTOG CDH23 CHRNA10 XIRP2 KCNN2 MYO1C EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 MSN TWF1 CASK SPTBN1 CHRNA9 SPTAN1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression H2AC14 EP300 H2BC12L H2AC8 H2AC6 ERCC6 H2AC7 H4C9 SMARCA5 H2AC20 H2AX GSK3B H2BC26 H2BC21 H3-3B H3C8 TBP BAZ1B H2BC17 H2BC12 H2BC13 H2BC14 KAT2B H2BC15 KAT2A H2AJ POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SF3B1 H2BC9 DDX21 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A POLR2E POLR2F POLR2H MYBBP1A H2AC19 POLR2K POLR2L H2AB1 ACTB H2AZ2 DEK DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function SEM1 RMI2 RMI1 TOP3A RAD51D RAD51B WRN RAD51C KAT5 EXO1 DNA2 MRE11 NBN BARD1 BRCA2 RAD51AP1 BRIP1 RBBP8 ATM BLM XRCC2 PALB2 RAD50 BRCA1 RAD51 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy DYNC1LI1 CETN1 TOMM20 DYNC1LI2 TOMM22 UVRAG MAP1LC3A FUNDC1 ATG9A ATG12 VDAC3 VDAC2 UBE2N TOMM40 ATG5 RHEB MTERF3 TOMM7 TOMM5 TOMM6 NBR1 PEX5 MFN1 USP30 MFN2 SQSTM1 CHMP4C CHMP4B CHMP4A MLST8 DYNC1I1 PIK3C3 WIPI1 BECN1 MTMR14 PRKAG2 DYNLL2 PRKAA1 CHMP2B MTOR CHMP2A HSP90AA1 MTMR3 DYNLL1 CHMP3 UBA52 UBE2D2 CHMP6 TBK1 OPTN CHMP7 DYNC1I2 PLIN2 UBB UBC PCNT RPS27A UBE2D3 ATG14 DYNC1H1 PARK7 PIK3R4 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 PRKAB1 RRAGA RRAGC ATG101 RRAGB ATG16L2 RRAGD ATG16L1 MAP1LC3B GABARAPL2 WDR45 MAP1LC3C RB1CC1 WIPI2 TOMM70 ATG4C ATG4B ATG4A ATG4D WDR45B AMBRA1 ULK1 GABARAP HDAC6 CSNK2A1 ATM CSNK2A2 ARL13B HSPA8 PRKAG1 CSNK2B PRKAG3 RPTOR UBE2L3 TSC2 TSC1 PRKAA2 PINK1 VDAC1 IFT88 CFTR ATG7 EPAS1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKN UBE2V1 PRKAB2 PLIN3 HSF1 VCP SLC38A9 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A12 SLC6A11 SLC6A13 SLC6A1 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors LRRC7 DLG1 KIF17 ACTN2 CASK GRIN1 APBA1 LIN7A LIN7C GRIN2A GRIN2C GRIN2D GRIN3B DLG2 GRIN3A DLG3 GRIN2B NBEA DLG4 CAMK2B CAMK2D CAMK2A LIN7B CAMK2G NEFL REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity CALM1 LBR TBL1XR1 HTT NCOR2 TNRC6C MOV10 AGO3 AGO4 NCOR1 AGO1 AGO2 CAMK4 TNRC6A TNRC6B HIPK2 GPS2 HDAC2 TBL1X HDAC3 HDAC1 FOXG1 AURKB CAMK2B CAMK2D CAMK2A PRKACA CAMK2G SIN3A ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases CASP4 CALM1 IL1B CALM3 CALM2 GSDMD CASP3 SERPINB1 CASP5 IL18 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA52 CUL1 PSMD12 PSMD11 UBB CDC20 PSMD14 FBXO5 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 BTRC PSMD2 PSMD3 PSMB1 PSMD1 FZR1 SKP1 ADRM1 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants ALK ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters SLC5A8 SLC17A5 SLC25A10 SLC25A1 SLC5A12 SLC25A11 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System NFKB1 TLR10 UNC93B1 TLR6 LY96 NFKB2 TLR5 NFKBIA TICAM1 S100A1 CD14 BTK MYD88 HMGB1 TLR4 CHUK IRAK4 FGB FGA TRAF3 FGG F2 IKBKB IKBKG SERPING1 TIRAP F12 TLR1 S100A9 S100A8 KLKB1 TLR2 RELA TLR7 TLR3 CD36 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity PSMA5 ESRRA SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 MSX2 PSMC1 NR3C1 PSMC2 ESR1 SKP2 DLX6 BMP2 PPARGC1A PPARGC1B CBFB GSK3B NKX3-2 DLX5 SKP1 TWIST1 STAT1 RBX1 STUB1 UBA52 CUL1 WWP1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC SMURF1 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 HIVEP3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 NUP107 KIF2A MIS12 PPP1CC KIF2C KIF2B DYNC1I1 CENPE NUF2 NUDC NUP160 NUP85 DYNLL2 BIRC5 B9D2 INCENP AURKB SPC24 PPP2R1A SPC25 ERCC6L ZWILCH CENPA CENPC CDCA5 KNTC1 PDS5B PDS5A WAPL CENPT CENPU SGO1 SEC13 SGO2 SMC3 NUP133 DYNLL1 RAD21 CKAP5 CENPF STAG1 STAG2 CENPH RANGAP1 PMF1 SMC1A MAPRE1 CENPI TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CENPP CCNB2 CENPQ CCNB1 CENPS NUP43 CLASP1 RANBP2 FIRRM DYNC1H1 NDE1 PLK1 CLIP1 MAD1L1 CDK1 NUP37 ITGB3BP NDC80 RPS27 BUB1 CLASP2 XPO1 SPDL1 NSL1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E KNL1 ZW10 DSN1 BUB1B RCC2 CDC20 ZWINT BUB3 AHCTF1 MAD2L1 KIF18A NDEL1 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME ABCC4 VAV2 ABCC5 NME2 HPRT1 RAC1 NME1 IMPDH1 GSTA2 IMPDH2 GSTA1 NUDT15 TPMT SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 VAV3 GSTM1 GUK1 GMPS VAV1 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins WDR48 STRN FIP1L1 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 KIF2A KIF2C PTTG1 KIF2B CENPE NUF2 EMD NUDC DYNLL2 PPP2R2A INCENP TUBA1A PPP2R1A ANAPC15 ANAPC16 CENPA UBE2D1 ANAPC10 CENPC ANAPC11 CDC23 CDC26 CDC27 VRK1 LEMD2 CDCA5 ANAPC7 PDS5B PDS5A UBE2C WAPL CENPT UBE2E1 ESPL1 CENPU UBE2S CDC16 LMNB1 ANAPC4 ANAPC5 SMC3 ANAPC1 DYNLL1 ANAPC2 RAD21 CKAP5 CENPF TUBA4A STAG1 STAG2 CENPH MAPRE1 CENPI SMC1A UBA52 TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CENPP CENPQ CCNB2 CENPS PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 CLASP1 PSMB7 PSMB4 PSMD6 DYNC1H1 PSMB5 PSMD7 PSMB2 NDE1 PLK1 PSMB3 PSMD2 TUBB4B CLIP1 PSMD3 TUBB4A PSMB1 PSMD1 MAD1L1 CDK1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 NDC80 RPS27 PSMC2 XPO1 SPDL1 TNPO1 NSL1 KPNB1 KNL1 ZW10 DSN1 RCC2 BUB1B CDC20 FBXO5 ZWINT BUB3 AHCTF1 MAD2L1 NDEL1 NUP107 NUP188 MIS12 RCC1 PPP1CC BANF1 NUP93 CHMP4C CHMP4B DYNC1I1 CHMP4A NUP205 POM121 NUP160 NUP85 BIRC5 B9D2 SPC24 NUP155 AURKB SPC25 ERCC6L ZWILCH CHMP2B CHMP2A NUP62 KNTC1 LBR NDC1 SEC13 SGO1 SGO2 NUP133 TUBB6 TUBB3 TUBB1 RANGAP1 PMF1 CHMP3 NUP54 CHMP6 CHMP7 TUBA4B VPS4A NUP43 RANBP2 TUBB8 SPAST IST1 TUBB8B CC2D1B TUBA8 TUBA1C TUBA1B NUP35 RAN TUBB2B TUBB2A NUP37 UBE2I ITGB3BP TUBAL3 TUBA3E TUBA3D TUBA3C SUMO1 BUB1 CLASP2 SIRT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E LEMD3 KIF18A ANKLE2 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA DHTKD1 DLD DLST ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress NFYA NFYB ASNS CXCL8 NFYC ATF3 CCL2 KHSRP DDIT3 DIS3 CEBPG ATF6 DCP2 PARN EXOSC7 HERPUD1 EXOSC6 EXOSC5 EXOSC4 ATF4 EXOSC9 CEBPB EXOSC8 EXOSC3 EXOSC2 IGFBP1 EXOSC1 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation GRIN1 CALM1 LRRC7 GRIN2A GRIN2C GRIN2D DLG2 DLG3 GRIA1 GRIN2B GRIA2 DLG4 GRIA3 CAMK2B GRIA4 CAMK2D DLG1 CAMK2A CAMK2G NEFL ACTN2 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f MPDU1 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVPR1A AVP IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB IKBKG CHUK CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling EP300 LYN RPS6KA5 NRAS NFKB1 RELB PRKACG CD209 PRKACB FYN PAK2 ICAM2 ICAM3 PAK1 PRKACA RELA HRAS RAF1 CREBBP PAK3 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane VAMP2 MYH9 RHOQ YWHAQ YWHAH PRKAB1 SNAP23 YWHAB AKT1 YWHAZ YWHAE PRKAG2 RAB4A MYO5A SLC2A4 MYO1C STXBP3 PRKAG1 YWHAG STX4 RAB8A PRKAG3 RALGAPA2 RALGAPB CALM1 C2CD5 RALA PRKAA2 RAC1 ASPSCR1 TBC1D1 TBC1D4 KIFAP3 EXOC8 EXOC7 LNPEP AKT2 EXOC4 KIF3A EXOC3 KIF3B EXOC6 EXOC5 EXOC2 EXOC1 RAB14 RAB11A RAB10 RAB13 PRKAB2 SFN TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex PIK3C3 UVRAG BECN1 CHMP3 CHMP6 CHMP2B CHMP7 CHMP2A PIK3R4 MAP1LC3B CHMP4C CHMP4B CHMP4A SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants STAT3 PIK3CA PIK3R2 NRAS PIK3CB PIK3R1 SOS1 PDGFRA STAT1 HRAS BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX15 LTA4H ALOX5 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress MCM7 MCM8 CDC6 MCM3 MCM4 CDC25A MCM5 MCM6 MCM2 CHEK1 RAD9B MCM10 DBF4 RAD9A RPA1 HUS1 RPA2 CLSPN RPA3 RAD1 RFC5 RFC3 RFC4 CDK2 RFC2 ATRIP CDC25C RAD17 ATR CDC7 ORC5 ORC4 ORC6 ORC1 ORC3 CDC45 ORC2 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors EP300 VEGFA UBE2I MYC ESR1 KDM5B CITED1 CITED2 CITED4 CGA SUMO1 NPM1 MYBL2 ATAD2 KIT CREBBP NOP2 YY1 ERBB2 EGFR TFAP2A TGFA TFAP2B WWOX CGB8 TFAP2C TFAP2D YEATS4 TFAP2E KCTD1 KCTD15 APOE CDKN1A PITX2 HSPD1 DEK RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 TBP GTF2B GTF2A1 GTF2F1 GTF2A2 GTF2F2 TAF9 TAF1L POLR2A POLR2B POLR2C GTF2E1 POLR2D GTF2E2 CDK7 POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH TAF8 POLR2K POLR2L TAF4B TAF7 TAF6 TAF7L TAF5 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence CABIN1 H2AC14 H2BC12L H2AC8 EP400 ASF1A H2AC6 H2AC7 ACD TINF2 TERF1 TERF2 POT1 TERF2IP UBN1 KAT5 H4C9 TP53 H2AC20 ATM H2AX HMGA1 CDKN1A RAD50 H2BC26 H2BC21 CDKN1B LMNB1 H1-1 H1-0 H1-3 H1-2 H2BC17 H1-5 H1-4 H2BC12 H2BC13 H2BC14 HIRA H2BC15 H2AJ H2BC11 CCNE2 CCNE1 CDK2 CCNA2 MRE11 CCNA1 H2BC9 H2BC8 H2BC5 H3-4 NBN H2BC3 H2BC1 RB1 H2AC19 H2AB1 HMGA2 H2AZ2 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair H2BC12L UBE2N RAD51B MAPK8 RAD51C RAD9B PAXIP1 RAD9A LIG1 LIG4 UBE2V2 EXO1 CLSPN H4C9 TOPBP1 RFC5 RFC3 RFC4 SMARCA5 RFC2 XRCC6 XRCC4 XRCC5 RBBP8 PRKDC H2AX BAP1 RAD50 PHF6 FEN1 DCAF8L1 DCAF8L2 BRCC3 PPP5C BABAM1 BABAM2 UIMC1 BAZ1B ABRAXAS1 RNF8 POLQ APBB1 EYA2 EYA3 EYA4 UBA52 RNF4 PSMD12 PSMD11 UBB NSD2 PSMD14 POLK PSMD13 UBC POLE H2BC9 RFC1 H2BC8 PARP2 H2BC5 PSMA7 MUS81 H2BC3 BRCA2 PSMB6 RPS27A PSMD8 LIG3 RAD51AP1 H2BC1 SLX4 EME1 PSMB7 EME2 PSMB4 PSMD6 FIRRM DDB1 FIGNL1 PSMB5 PSMD7 GEN1 SLX1B PSMB2 XRCC2 PSMB3 PSMD2 XRCC3 PSMD3 PALB2 SPIDR PSMB1 PSMD1 POLD3 POLD4 POLD2 ADRM1 TP53BP1 XRCC1 PSMA5 SEM1 CUL4A PSMA6 POLE4 PSMA3 PSMC5 PIAS4 PSMA4 PSMC6 ERCC4 POLE2 RNF168 PSMC3 ERCC1 UBE2I PSMA1 POLE3 DCLRE1C PSMA2 RIF1 PSMC4 POLL PSMC1 CUL4B MDC1 RTEL1 NHEJ1 PSMC2 POLM TDP2 TDP1 RAD52 KAT5 CHEK2 CHEK1 UBXN1 SUMO1 HUS1 SUMO2 POLD1 ABL1 KDM4A DNA2 KDM4B RHNO1 TP53 ATRIP BARD1 SIRT6 RAD17 ATM ATR BRCA1 H2BC26 RAD51 H2BC21 HERC2 RMI2 RMI1 PPP4R2 TOP3A TIPIN TIMELESS PPP4C RAD51D RBX1 H2BC17 PCNA WRN H2BC12 H2BC13 PARP1 H2BC14 H2BC15 RPA1 H2BC11 RPA2 KPNA2 RPA3 RAD1 CDK2 CCNA2 MRE11 CCNA1 H3-4 NBN EYA1 BRIP1 BLM POLH NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle SNAP25 VAMP2 TSPOAP1 UNC13B RAB3A SYT1 STX1A MAOA CPLX1 RIMS1 PPFIA1 PPFIA4 SLC18A2 SLC22A2 PPFIA3 SLC22A1 PPFIA2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling PRKAR2A PRKAR2B PRKACG PRKACB GNAS ADCY9 PRKAR1B PRKAR1A ADCY4 PRKACA ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C ANAPC7 UBE2C CCNB1 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 PLK1 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDK1 CDC23 CDC26 CDC27 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells CXCR4 NANOG SOX17 BMP4 PRDM1 CBFA2T2 TET2 PDPN POU5F1 EOMES TFAP2C NANOS3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSME1 PSMA4 CD207 FCGR1BP PSMC6 MRC2 PSMC3 PSMA1 FCGR1A PSMA2 PSMC4 PSMC1 PSMB10 PSMC2 PSMB8 PSMB9 PSME2 PSMD12 PSMD11 MRC1 PSMD14 PSMD13 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism BLVRB SLCO1B1 BLVRA SLCO1B3 UGT1A1 ALB GSTA1 HMOX1 UROS HMOX2 PPOX ABCC1 ABCC2 FABP1 COX15 UGT1A4 ALAS2 ALAS1 ALAD FECH UROD COX10 ABCG2 CPOX HMBS REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2AC14 H2BC12L DPF1 DPF2 H2AC8 DPF3 H2AC6 H2AC7 SMARCC1 SMARCC2 SPOCD1 H4C9 SS18L1 SMARCA2 SMARCA4 H2AC20 H2AX PIWIL4 CHD4 CHD3 DNMT3L H2BC26 BCL7A H2BC21 H3-3B BCL7C BCL7B H3C8 SS18 ACTL6A DNMT3A ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 C19orf84 SMARCD1 HDAC2 H3C15 SMARCD2 SMARCD3 MBD3 HDAC1 H2BC9 H2BC8 H2BC5 MTA1 H2BC3 RBBP4 H2BC1 GATAD2B GATAD2A SMARCB1 RBBP7 MTA2 MTA3 H2AC19 H2AB1 SMARCE1 ACTB H2AZ2 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair ERCC3 ERCC2 ERCC6 UBE2N LIG1 UBE2V2 RFC5 RFC3 RFC4 RNF111 RFC2 CETN2 GPS1 ELL ZNF830 ACTL6A ISY1 UBA52 POLR2A UBB POLR2B POLK POLR2C NFRKB POLR2D UBC POLE RFC1 PARP2 POLR2G ACTR5 MCRS1 USP45 POLR2I RAD23A RPS27A LIG3 POLR2J ACTR8 GTF2H1 CHD1L GTF2H2 RAD23B GTF2H3 XAB2 DDB1 GTF2H4 INO80C GTF2H5 INO80B RUVBL1 INO80E INO80D XPA COPS7B COPS7A PPIE XPC POLD3 TFPT POLD4 TCEA1 POLD2 XRCC1 UVSSA INO80 CUL4A POLE4 COPS3 COPS6 COPS5 ERCC4 PIAS3 POLE2 ERCC1 UBE2I POLE3 ERCC5 COPS8 AQR CUL4B COPS4 PIAS1 COPS2 PRPF19 SUMO1 SUMO3 SUMO2 POLD1 YY1 CDK7 MNAT1 ERCC8 DDB2 RBX1 PCNA PARP1 RPA1 RPA2 RPA3 USP7 POLR2E POLR2F POLR2H CCNH POLR2K POLR2L ACTB FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation FGFBP1 FGF1 FGF7 FGFBP2 FGF4 FGFBP3 FGF16 FGF22 FGF3 FGF9 FGF18 FGF10 FGF20 FGF23 FGF6 FGF2 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription H2AC14 EP300 STAT3 H2BC12L H2AC8 H2AC6 H2AC7 HIF1A NFKB2 MYC CTNNB1 MYCN IRF1 KMT2A KMT2C CREBBP H4C9 NFE2L2 H2AC20 EZH2 H2AX DPY30 ASH2L TCF7L1 RELA H2BC26 JUN TEAD1 H2BC21 H3-3B TCF7L2 TEAD2 TEAD3 H3C8 TEAD4 WDR5 NFKB1 ATF3 FOS EED STAT1 H2BC17 JUND H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 EPAS1 FOSB H3C15 TCF7 SUZ12 LEF1 H2BC9 H2BC8 H2BC5 H2BC3 RBBP4 BRD4 H2BC1 RBBP5 WWTR1 RBBP7 H2AC19 YAP1 H2AB1 H2AZ2 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GP9 F9 GP1BA GP1BB F11 GP5 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling GNAT3 GNAZ PRKACG GNAI3 GPER1 PRKACB ADCY9 PRKAR1B GNG3 PRKAR1A GNG2 ITGB1 GNG5 ADCY4 GNG4 GNG7 ADCY3 ADCY2 GNG8 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A GNG10 PRKAR2B GNG12 GNAS GNG11 GNG13 GNB2 GNAI1 GNAI2 GNB1 SRC GNB4 GNB3 GNB5 PRKACA GNGT1 GNGT2 ITGA5 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis POLE4 POLE2 POLE3 PCNA UBA52 RPA1 UBA7 RPA2 UBE2L6 POLD1 REV1 ISG15 RPA3 TRIM25 RFC5 UBB RFC3 RFC4 POLK RFC2 UBC POLE RFC1 RPS27A USP10 PCLAF USP43 POLI POLH POLD3 POLD4 POLD2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGC PIGB DPM2 PIGA PIGM PIGL PIGG PIGO PIGF PIGN PIGH PIGP PIGZ PIGW PIGV PIGY PIGX TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP62 NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 NUP50 KPNA1 NUP54 NUP210 NUP93 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 NUP153 KPNB1 NUP35 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 GPC1 EXT2 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 SDC4 AGRN SDC2 SDC3 HSPG2 EXT1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release AIFM2 PMAIP1 TP53 BID BBC3 STEAP3 TP53BP2 PRELID3A BNIP3L PRELID1 TP53AIP1 TP53INP1 ATM TP63 TP73 PPP1R13B TRIAP1 BAX ZNF420 CREBBP DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER INO80 CUL4A COPS3 COPS6 COPS5 ACTL6A DDB2 COPS8 CUL4B COPS4 RBX1 COPS2 PARP1 UBA52 UBB YY1 NFRKB UBC PARP2 CETN2 ACTR5 MCRS1 RPS27A RAD23A ACTR8 RAD23B DDB1 INO80C INO80B INO80E RUVBL1 INO80D GPS1 COPS7B COPS7A XPC TFPT ACTB METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA TYW3 TYW2 ERCC3 TYW1 LCMT2 PQBP1 NXT1 EIF4A3 CASC3 ERCC2 GLE1 SRRT MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 SRRM1 THOC6 DDX39A SNRNP200 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 CTNNBL1 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 PRCC FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 CCAR1 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB PCBP1 NXF2B PCBP2 RNPS1 SYMPK RBM10 DHX15 DHX16 WBP11 DDX46 DDX42 RBM17 ZNF473 BUD31 TFB1M RBM22 DDX23 CSTF2T SMNDC1 U2SURP CLP1 HNRNPF HNRNPA2B1 SNRPA1 PSMD12 PSMD11 PSMD14 PSMD13 SF3B4 SF3B5 SF3B2 RPLP1 SF3B3 PSMA7 RPLP0 SF3B6 PSMB6 PSMD8 SF3A3 SF3A1 TRMT112 PSMB7 SF3A2 PSMB4 XAB2 PSMD6 RPLP2 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 NCL PSMD3 PSMB1 PSMD1 CHERP ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PUF60 PSMA1 SNRPB2 PSMA2 PSMC4 PSMC1 AQR PSMC2 TP53RK PRPF19 PCF11 YWHAB HSPB1 PTBP1 ELAVL1 ZFP36 APOBEC3C XPO1 APOBEC1 HNRNPH1 KHSRP AKT1 APOBEC2 TNPO1 APOBEC3H NUP214 HNRNPA1 APOBEC4 EFTUD2 DIS3 ADAR ADARB1 PRKCD HNRNPM PRKCA A1CF APOBEC3A YWHAZ XRN1 APOBEC3B MAPKAPK2 PABPC1 DCP2 SET RPL22L1 ANP32A PARN ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 MAPK14 MAPK11 DCP1A HSPA1A EIF4G1 TNKS1BP1 PRMT5 CNOT6L IGF2BP3 IGF2BP2 CNOT10 CNOT4 CNOT6 HSD17B10 CNOT7 CNOT1 CNOT11 MTERF3 CNOT2 CNOT3 NUP107 NUP188 CNOT8 CNOT9 NUP210 GTF2F1 GTF2F2 NUP93 RPL23A MTPAP NUP205 FASTKD2 POM121 FASTKD5 TBRG4 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 SUPT5H EIF4A2 EIF4A1 TUT7 NUP62 TUT4 STEEP1 TCERG1 GPATCH1 PNN WDR77 METTL3 ZNF830 SF1 SLBP NDC1 DHX8 SEC13 PRKRIP1 CWF19L2 NCBP1 SNU13 NUP133 RNPC3 RPL27A NCBP2 HTATSF1 WDR70 DHX35 ZRSR2 PRPF38A PABPN1 EIF4E SMU1 NUP50 EIF4B PPP1R10 PAIP1 NKAP NUP54 UBL5 IGF2BP1 PRPF40A GCFC2 PRPF18 SDE2 TUT1 RNMT FAM32A CACTIN PPP1R8 SRSF10 SRSF12 PRPF31 PDCD7 POLR2A POLR2B RBMX2 PAPOLG NUP42 POLR2C SNIP1 SNRNP35 POLR2D IK PRP4K LENG1 POLR2G PRPF4 NUP43 POLR2I PRPF3 SNRNP27 SNRNP25 POLR2J SNRPC RAE1 SNRPA RANBP2 SRSF8 RNGTT ZMAT2 ZMAT5 CCDC12 YJU2 LSM5 LSM4 LSM3 LSM2 LSM8 PPP1CA LSM7 LSM6 NUP35 RBM25 PPWD1 DDX41 USP39 SART1 PAN2 METTL14 PAN3 RAN SNRNP70 TFIP11 NUP37 SYF2 LUC7L3 C9orf78 NSRP1 WBP4 RNF113A RBM39 PPIL2 WTAP MFAP1 RBM42 ACIN1 SNRNP48 DDX49 BUD13 SMG1 DDX47 FAM50A SMG9 WDR3 SMG7 FCF1 SMG8 NAT10 SMG5 THUMPD1 SMG6 PWP2 WDR46 UPF1 WDR43 PNRC2 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 GAR1 DHX37 RRP36 UTP20 DCAF13 UTP6 CLNS1A NOP14 SNUPN UTP4 UTP3 PPP2CA PNO1 KRR1 RCL1 TBL3 MPHOSPH10 NOL11 NOP10 RPL26L1 RPL4 RPL5 RPL30 RPL3 RPL32 RBMX RPL31 RPL34 RPL8 RPL6 NOP2 RPL7 RPL36 RPL35 RPL38 RPL37 RPL39 YBX1 RPL21 RPL23 RPL22 RPL24 RPL27 RPL26 RPL29 EPRS1 RPL28 TRMT10C PRORP ELAC2 TRNT1 RPL41 HNRNPC RPL3L PPP1CB PPP2R2A PPP2R1A RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 CSNK1D RPL19 SUPV3L1 CSNK1E PNPT1 RBM27 SLIRP REXO2 ZCCHC7 LRPPRC RBM26 YTHDC1 ZC3H4 YTHDC2 ZC3H3 RPS15 TENT4B EXOSC10 RPS14 ZC3H18 UBA52 RPS17 ZFC3H1 C1D LTV1 RPS16 RRP1 DXO FTSJ3 RPS19 MPHOSPH6 EBNA1BP2 SNRPD2 ISG20L2 RPS18 SNRPD1 ERI1 LAS1L NOL12 SNRPD3 RBM28 RIOK2 RPS11 RIOK1 TEX10 RPS10 SENP3 GNL3 RPS13 UBB NIP7 RPS12 NOL9 PES1 RIOK3 UBC WDR18 WDR12 GRSF1 BYSL BOP1 RPS27A TSR1 DDX6 LSM1 PATL1 EDC3 EDC4 RPS4Y2 DCP1B RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 RPL37A TGS1 GSPT2 GSPT1 UPF3A RPL36A UPF2 ETF1 RPL35A RPS27L RBBP6 RPS15A RPS3 RPS2 FAU GEMIN2 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA ZCRB1 RPL39L GEMIN4 SNRPG GEMIN5 GEMIN6 SNRPE GEMIN7 SNRPF GEMIN8 SNRPB CCNH DDX5 SMN2 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM1 MRM2 MRM3 HBS1L NT5C3B SKIC3 DCPS RPL10L RPL10A WDR82 RPS4X RPS3A DDX20 NUDT21 RPL13A FUS ISY1 BCAS2 HNRNPA3 GPKOW CDC5L CPSF7 XRN2 SF3B1 DHX9 SUGP1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 RPL18A RPL36AL PPIE PPIH PPIG TENT4A MTREX SKIC2 HNRNPU HNRNPR NOP58 ZCCHC8 HNRNPL HNRNPK HNRNPD TRA2B WDR33 PHF5A PAPOLA TXNL4A NOP56 SNRPN RAMAC LSM10 LSM11 CDK7 PLRG1 SKIC8 DNAJC8 FIP1L1 MNAT1 PPIL1 SNRNP40 PPIL3 PPIL4 SRRM2 PHAX CRNKL1 CSTF3 CSTF2 SNW1 CSTF1 QNG1 URM1 POP5 WDR4 POP7 THADA HNRNPH2 RBM7 PELP1 LAGE3 TSEN15 POP1 OSGEP POP4 THG1L ALKBH8 RPP30 RTCB TRMT44 ZBTB8OS TRDMT1 TSEN2 PUS3 TSEN54 TRMT10A METTL1 CWC25 RPP38 NSUN2 CWC27 RPP21 TPRKB CWC22 RPP25 ADAT1 TSEN34 NSUN6 DDX1 TRMT1 RPP14 C2orf49 CDKAL1 RTRAF PUS7 PRPF6 FTSJ1 PRPF8 RPP40 TRIT1 XPOT CPSF4 ADAT3 FAM98B ADAT2 CPSF1 DUS2 RPL9P9 CPSF3 TRMT9B CPSF2 QTRT1 CWC15 GON7 QTRT2 CTU2 CTU1 TRMT6 TRMT13 TRMT11 YRDC TRMT61A RBM5 TRMU OSGEPL1 DDX21 MTO1 TRMT61B GTPBP3 POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L TYW5 TRMT5 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab CDC37 ERBIN ERBB2 HSP90AA1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants FLT3 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm SHH TEAD2 SMAD2 TEAD4 TCF7 SMAD3 LEF1 FOXA1 CTNNB1 TBXT FOXA2 NOTO YAP1 FOXH1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria BCL2 AKT1 BID YWHAZ YWHAE YWHAQ PPP3CC YWHAH YWHAG YWHAB AKT2 AKT3 BAD PPP3R1 SFN SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 EP300 PSEN2 MAMLD1 FCER2 APH1A NEURL1B APH1B CNTN1 MDK MIB2 UBA52 GZMB ADAM10 PSENEN UBB MAML2 PSEN1 UBC MAML1 RBPJ DLL1 RPS27A HES5 NCSTN JAG1 DLL4 MAML3 NOTCH2 NEURL1 HES1 MIB1 NOTCH2NLA JAG2 NOTCH2NLC NOTCH2NLB PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand PRIM2 PRIM1 POLA1 POLA2 PCNA LIG1 RPA1 RPA2 POLD3 POLD1 FEN1 POLD4 POLD2 DNA2 RPA3 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids LCN9 LCN15 SLC27A4 SLC27A1 LCN12 APOD LCN1 SLC27A6 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity SNAP25 SV2C SV2B STX1B SYT1 SV2A VAMP1 STX1A VAMP2 SYT2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection ERCC3 ERCC2 GTF2F1 GTF2F2 RNMT POLR2A POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 RNGTT GTF2H4 POLR2E GTF2H5 POLR2F POLR2H SUPT5H CCNH POLR2K POLR2L HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation GPC1 NAGLU CTSL GPC3 GPC2 IDUA GPC5 GPC4 GPC6 SDC1 SGSH IDS SDC4 AGRN HPSE2 SDC2 SDC3 HSPG2 HPSE DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d ALG3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation CP LTBP1 C3 APOL1 AHSG PRKCSH SERPINA10 IGFBP7 CHRDL1 WFS1 FGA FGG F5 HSP90B1 PNPLA2 SERPINC1 KNG1 FSTL1 SERPIND1 FSTL3 PROC MGAT4A MELTF PDIA6 MFGE8 FN1 CST3 TGOLN2 IL6 APOA2 APOA1 PENK APOA5 LGALS1 EVA1A CCN1 CHGB IGFBP5 DMP1 IGFBP4 C4A SHISA5 BPIFB2 CALU MXRA8 SPARCL1 SCG2 STC2 AMELX AMBN TMEM132A MATN3 SPP2 HRC PRSS23 BMP15 MEPE DNAJC3 QSOX1 RCN1 ENAM AMTN TNC FAM20C VWA1 APLP2 FAM20A ITIH2 SCG3 AFP GOLM1 NUCB1 IGFBP1 SDC2 FBN1 MEN1 APP ALB PCSK9 VCAN LAMB2 GAS6 ADAM10 TF ANO8 NOTUM CDH2 FUCA2 LAMC1 MIA3 VGF GPC3 TIMP1 CKAP4 KTN1 MBTPS1 FGF23 P4HB APOB SPP1 LAMB1 SERPINA1 IGFBP3 APOE BMP4 CSF1 MSLN CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions CDH8 JUP CTNND1 CDH11 CDH24 CTNNA1 CTNNB1 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase DFFB DFFA HMGB2 CTNNB1 CDH1 ACIN1 BMX KPNA1 HMGB1 CASP6 DNM1L ADD1 CLSPN DBNL GSN VIM BCAP31 STK24 STK26 GAS2 PRKCD MAPT DSG2 SATB1 TJP2 KPNB1 ROCK1 APC DSP CASP3 LMNB1 FNTA H1-1 H1-0 H1-3 PKP1 H1-2 H1-5 OCLN TJP1 H1-4 CASP8 DSG3 PAK2 DSG1 BIRC2 PLEC PTK2 PRKCQ SPTAN1 CASP7 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression NCOA1 NCOA2 NPAS2 NCOA6 CLOCK MED1 BHLHE40 TBL1XR1 BHLHE41 KLF15 NOCT BMAL2 HELZ2 RXRA PPARA TGS1 AVP CREBBP SERPINE1 TBL1X F7 SMARCD3 CHD9 BMAL1 CARM1 NAMPT INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling MAP3K8 MAP2K4 UBE2N TAB3 TAB2 TAB1 ALPK1 NLRX1 TOLLIP AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 SQSTM1 PELI1 LRRC14 TRAF6 USP14 PELI3 PELI2 NLRC5 USP18 TIFA S100B SAA1 NOD1 IL1RN NOD2 IL1R2 IL1A IL1B BTRC RELA SKP1 FBXW11 NFKB1 TRAF2 CASP8 UBA52 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 APP PSMC3 PSMA1 NFKB2 PSMA2 PSMC4 NFKBIA PSMC1 PSMC2 IRAK3 CHUK IKBKB TP53 IKBKG RIPK2 IL1R1 MAP2K1 RBX1 MAP3K7 UBE2V1 MAP3K3 MAP2K6 IRAK1 IRAK2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression H2AC14 ERCC3 H2BC12L SAP130 H2AC8 ERCC2 H2AC6 H2AC7 SAP30BP SAP30 DNMT1 BAZ2A H4C9 SUDS3 SMARCA5 CDK7 H2AC20 MNAT1 H2AX SUV39H1 H2BC26 SIN3B SIN3A H2BC21 H3-3B DNMT3B H3C8 UBTF TBP H2BC17 SIRT1 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 H3C15 HDAC1 H2BC9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 MBD2 TAF1C H2BC1 GTF2H1 GTF2H2 SAP30L GTF2H3 TAF1A GTF2H4 POLR2E GTF2H5 POLR2F SAP18 POLR2H CCNH H2AC19 POLR2K POLR2L H2AB1 RRP8 ARID4B H2AZ2 TTF1 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins CDH19 HEYL SOX10 CTNNB1 ZC3H12A TNRC6C JUP MOV10 AGO3 AGO4 SP1 AGO1 AGO2 SNAI1 CDH11 CTNNA1 TNRC6A TNRC6B ANGPTL4 CTNND1 ADAM33 PRDM8 ILF3 FOXF1 BHLHE22 CDH8 HOXC8 ZEB2 ADAM19 CDH24 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers ERLIN2 NOX4 JAK2 HEYL PIM1 MAPK9 MAPK8 LMO7 PORCN QKI ZC3HC1 FOXM1 KSR1 KSR2 PPM1B BIRC6 LRP5 LRP6 PRF1 GCC2 SEC31A MIB1 HEY1 HEY2 VCL LRRFIP1 IQGAP1 BCL2A1 DCTN1 IL10 RRBP1 ERLEC1 MSN FAM131B DKK1 DKK2 DKK4 BIN2 BRAP PSMD12 PSMD11 NOTCH1 PSMD14 MRAS PSMD13 RBPJ DLL1 PSMA7 PSMB6 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 RNF43 PSMD2 PSMD3 PSMB1 BAG4 PSMD1 ADRM1 PSMA5 SEM1 PSMA6 DUSP16 LYN PSMA3 DUSP10 PSMC5 PSMA4 PSMC6 DUSP6 DUSP7 PSMC3 PSMA1 PSMA2 PTPN12 PSMC4 GOLGA4 PSMC1 MYH9 PSMC2 CTNNB1 BCL11A ZMYM2 FOXO6 FOXO4 KREMEN1 FOXO3 FOXO1 KREMEN2 PDGFRA YWHAB FGF6 CUX1 SHOC2 AKT1 MAPKAP1 ESRP1 MARK3 DLL4 NEURL1 CDKN1A NTRK2 BDNF TGFBR1 TGFBR2 MAP2K1 MAP2K2 RAP1A RBX1 MAPK1 BRAF MAPK3 PRKAR1A RICTOR FGF1 FRS3 FGF4 NPM1 FGF16 FGF9 FGF18 FGF20 PIK3CD SOS1 PIK3CG FGF23 CSNK1A1 TGFA YES1 CASP9 SPRED3 SPRED2 SPRED1 HRAS NRAS NF1 IHH MDM2 PRR5 GTF2F1 GTF2F2 SQSTM1 FLT3 MLST8 JUNB TNKS TNKS2 TPR ATIC MTOR PIK3R3 PIK3R6 PIK3R5 HDAC10 NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I ITGA2B POLR2J RANBP2 HDAC4 ESR1 CHUK KDM7A EIF2AK3 HDAC8 TP53 PTEN CLTC AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB APC PPP2R1B PPP2R5E CDC37 ERBIN PHB1 TWIST1 KIT NTRK3 FGF2 SMAD2 SMAD4 SMAD3 VWF ESR2 NR4A1 JAG1 CAMK2B NTF3 CAMK2D CAMK2A HES1 CAMK2G ALK BCR PSEN2 IRS1 PIK3R2 PIK3CB APH1A PIK3R1 APH1B MYC AGK FRS2 PIK3CA PTPN6 ITGB3 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 FGB FGA TGFB1 FGG PSENEN KRAS EGF ERBB2 PLCG1 EGFR PPP1CB PPP2R1A CEBPB SKP1 HSP90AA1 TCF7L2 AKAP9 UBA52 KANK1 AKT2 AKT3 CUL1 SHC1 CCNB1 UBB UBC RPS27A TPM4 TPM3 CLIP1 CEP43 BCL2L11 BAD STAT3 BCL2L1 MAP3K11 GZMB ADAM10 RAF1 ADAM17 PSEN1 LCK TYK2 NCSTN SRC CSK STAT1 SPTBN1 RPS6 CLCN6 RAC2 RB1 FKBP1A VCP RHOG PAPSS1 CCNC VAV1 SYVN1 DERL2 OS9 FYN GSK3A PPP1CC FLT3LG TRAK1 PDGFB CD19 PDPK1 CD28 STRN GAB2 CREBBP CD86 KLB CD80 PDGFRB FGF19 FGFR4 AKT1S1 TRAT1 RPS6KB2 PIK3AP1 PTPN11 EPGN ARRB1 FGFR1OP2 ZC3HAV1 AP3B1 JAG2 FN1 PPFIBP1 CALM1 SHH DUSP8 DUSP9 NEURL1B HHAT NCOR2 KAT2B KIAA1549 KAT2A NCOR1 GOLGB1 KDR TRIM24 TBL1X GRB2 IL22 AGTRAP IRS2 CNKSR2 CNKSR1 AGGF1 PEBP1 TENT4A MYO18A EP300 ETV6 WDCP FZD5 FZD4 ZAP70 FZD6 FZD8 TFG ARRB2 CTBP2 CTBP1 TBL1XR1 ICOS DNMT1 WDR48 APBB1IP IL10RA CARS1 RAP1B HGF HDAC11 GAB1 FAM114A2 MET MCL1 AREG MAML2 CDK8 MAML1 TRIP11 EEF1G IRF4 HDAC5 FIP1L1 HDAC9 HDAC6 MAML3 HDAC7 FGF7 GSK3B STAT5A SEL1L FGF22 FGF3 STAT5B FGF10 WNT3A JUN TLN1 SNW1 MAMLD1 FXR1 TSC2 CDKN1B HIP1 RAC1 NRG1 KIF5B NRG2 LMNA EREG BTC NRG3 NRG4 RNF213 MIB2 ATG7 HBEGF KLC1 CPSF6 CBL FGFR3 FGFR2 HDAC2 FGFR1 HDAC3 HDAC1 HES5 ARAF MPRIP POLR2E POLR2F SND1 EML4 POLR2H DHH POLR2K POLR2L ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin INHBB INHBA FST FSTL3 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding CCT2 TCP1 CCT6B GNA14 GNG3 GNA15 GNG2 RGS9 GNG5 RGS6 GNG4 RGS7 GNG7 GNA11 GNG8 CCT8 CCT7 CCT5 CCT4 RGS11 GNG10 GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 CSNK2A1 PDCL GNB4 GNB3 CSNK2A2 GNB5 GNGT1 CSNK2B GNGT2 CCT3 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo AMOTL1 SAV1 DVL2 CASP3 WWC1 MOB1B MOB1A YWHAE STK4 STK3 LATS1 LATS2 TJP1 TJP2 WWTR1 YWHAB YAP1 NPHP4 AMOTL2 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation LOXL3 LTBP4 FBN1 LOXL4 LTBP2 LTBP3 LTBP1 LOXL1 LOXL2 TGFB2 TGFB3 LOX ITGB3 MFAP5 BMP2 ITGB1 BMP10 MFAP4 MFAP3 ITGB5 MFAP2 ITGB8 ITGAV ITGB6 TGFB1 GDF5 ELN FURIN EFEMP2 EFEMP1 FBN2 BMP4 FBN3 VTN FBLN1 FBLN2 FBLN5 ITGA8 BMP7 ITGA5 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis ISCA2 FDX2 ISCA1 GLRX5 FDXR HSCB LYRM4 SLC25A28 FXN SLC25A37 FDX1 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 PSEN2 MXD4 CSN2 APH1A STMN1 APH1B ADAP1 NRG1 NRG2 TAB2 ESR1 EREG BTC NRG3 CXCL12 NRG4 NCOR1 HBEGF SPARC GFAP PGR PSENEN ADAM17 S100B PSEN1 NCSTN WWOX SRC APOE STAT5A YAP1 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration CBFB RUNX3 ITGAL SPP1 ITGA4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression AGPAT1 MLXIPL FASN ACACB ACACA ACLY MLX REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling NLRC5 IKBKB USP18 TP53 UBB IKBKG UBC RPS27A TRAF2 NLRX1 CASP8 N4BP1 UBA52 CHUK IKBIP LRRC14 USP14 TRAF6 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors MAPK10 MAPK3 FOS MAPK14 MAPK11 JUN MAPK9 ATF2 MAPK8 MAPK1 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PER2 PER1 PSMC6 PER3 PSMC3 PSMA1 PSMA2 CRY2 PSMC4 CRY1 PSMC1 PSMC2 BTRC UBE2D1 SKP1 FBXW11 RBX1 UBA52 FBXL21P CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 FBXL3 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells VAV2 PSEN2 LYN APH1A EFNA5 APH1B EFNA4 RAC1 EFNB2 FYN CLTB EFNB1 EFNB3 EFNA1 EFNA3 EFNA2 MMP2 MMP9 CLTCL1 EPHA2 EPHB6 ADAM10 EPHB2 EPHB1 EPHB4 PSENEN EPHB3 EPHA5 EPHA7 EPHA6 EPHA8 PSEN1 CLTC CLTA AP2A1 EPHA1 AP2B1 EPHA3 NCSTN AP2A2 EPHA10 DNM1 AP2S1 YES1 TIAM1 VAV3 EPHA4 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PRXL2B PTGDS CBR1 PTGIS PTGR2 PTGES2 PTGES3 PTGS2 PTGS1 HPGD AKR1C3 HPGDS PTGES CYP8B1 TBXAS1 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation SRRT CDC40 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 HNRNPC GTF2F1 GTF2F2 SRSF7 SRSF9 SRSF1 U2AF1 U2AF1L4 U2AF2 CCAR1 SRSF11 PCBP1 PCBP2 PPP1CB SYMPK RBM10 DHX15 TCERG1 DDX46 NUDT21 DDX42 RBM17 NCBP1 NCBP2 HTATSF1 FUS CSTF2T PABPN1 PPP1R10 SMNDC1 UBA52 U2SURP PRPF40A HNRNPA3 CLP1 SNRPD2 SNRPD1 HNRNPF TUT1 HNRNPA2B1 SNRPD3 PPP1R8 CPSF7 SNRPA1 SRSF10 XRN2 SRSF12 POLR2A UBB POLR2B SF3B1 PAPOLG DHX9 POLR2C POLR2D UBC SF3B4 SF3B5 SF3B2 POLR2G SUGP1 SF3B3 SF3B6 POLR2I RPS27A POLR2J SF3A3 SNRPC SF3A1 SNRPA SF3A2 SRSF8 PPP1CA CHERP RBM25 SNRNP70 HNRNPU PUF60 HNRNPR SNRPB2 RBM39 HNRNPL HNRNPK HNRNPD TRA2B PCF11 WDR33 PHF5A PTBP1 PAPOLA HNRNPH1 SNRPN HNRNPA1 HNRNPM DNAJC8 FIP1L1 SRRM2 RBBP6 CSTF3 CSTF2 CSTF1 HNRNPH2 RBMX CPSF4 CPSF1 CPSF3 CPSF2 RBM5 SNRPG SNRPE YBX1 SNRPF POLR2E POLR2F POLR2H SNRPB DDX5 POLR2K POLR2L HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2AC14 TRIM28 ELK1 DYNC1LI1 DYNC1LI2 NUP37 H2AC8 H2AC6 H2AC7 TBL1XR1 NUP107 NUP188 DAXX H2BC18 NUP210 NUP93 DYNC1I1 H4C9 NUP205 POM121 NUP214 AAAS EGFR NUP160 POM121C DYNLL2 NUP85 TPR NUP88 H2AC20 NUP155 EZH2 NUP153 PML H2BC26 H2AC17 H2AC12 NUP62 H2BC21 H3C8 CBX1 NFKB1 NDC1 SEC13 EED NUP133 DYNLL1 H2BC17 H2AC25 H2BC12 H2AC21 NCOR2 H2BC13 H2BC14 H2BC15 NUP50 ITGB1 NUP54 NCOR1 H2BC11 DYNC1I2 GPS2 H3C15 TBL1X HDAC3 NUP42 SUZ12 H2BC9 H2BC8 H2BC5 NUP43 H2BC3 RBBP4 H2BC1 RAE1 RANBP2 DYNC1H1 RBBP7 H2AC19 H2AC1 NUP35 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib CDC37 ERBIN ERBB2 HSP90AA1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions INPP5D LYN PTPN6 ITGB3 PECAM1 YES1 PLCG1 FYN LCK ITGAV PTPN11 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle GLS2 SLC17A7 SNAP25 SLC1A1 SLC1A2 SLC1A3 VAMP2 ARL6IP5 SLC1A6 TSPOAP1 SLC1A7 UNC13B RAB3A SYT1 SLC38A2 STX1A CPLX1 GLS RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 GGCX F9 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation CD3G FCGR3A SYK FGR HCK FYN FCGR1A FCGR2A IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YES1 IGHG3 IGHG4 IGHG1 IGHG2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism HPD GSTZ1 QDPR ASRGL1 FAH HGD PCBD1 IL4I1 PAH TAT KYAT1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification GNAT3 GNAI3 GNA14 GNA13 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 P2RY1 GNA11 GNG8 GNG10 GNG12 GNG11 GNG13 P2RY12 GNB2 GNAI1 GNAQ GNAI2 GNB1 PLA2G4A GNB4 GNB3 TBXA2R AAMP GNB5 GNGT1 MAPK14 GNGT2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate AMY1B AMY1C SI LCT CHIT1 MGAM CHIA AMY2A AMY1A AMY2B TREH GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation GNAT3 GNAI3 KCNJ2 KCNJ3 ADCY9 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 ADCY4 GNG4 KCNJ10 GNG7 ADCY3 ADCY2 GNG8 KCNJ12 ADCY1 KCNJ9 ADCY8 ADCY7 ADCY6 KCNJ15 ADCY5 KCNJ16 GNG10 GNG12 GNAL GNG11 GNG13 GNB2 GNAI1 GNAI2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA BCKDHB DBT MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling HGF CRKL RAB4B GAB1 MET CRK GGA3 RAB4A ARF6 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription ZFHX3 RUNX3 TP53 SMAD4 SMAD3 CDKN1A TGFB1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking SEC16A CAPZB KIF13B SEC23IP CNIH1 CNIH2 KIF1C FOLR1 KIF1B CNIH3 KIF1A IL7R BET1 KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIFC2 KIF2A KIFC1 SPTB KIF2C KIF2B CENPE KDELR1 KIF26A CAPZA1 GCC2 KIF26B CAPZA2 ANK2 SPTBN4 SPTBN5 SEC31A COPB1 SH3GL3 SH3GL1 HGS RAB7A RALA SPTA1 DCTN1 VAMP7 CD4 SURF4 ARF3 ARF1 CD3D GOLGA2 VAMP2 GOLGA4 SEC22B MYH9 GRIA1 SH3KBP1 NSF PRKAB1 YWHAB AVP CUX1 AKT1 YWHAZ EPS15 MYO5A MYO1C STXBP3 HSPA8 PRKAG1 STX4 CHM PRKAG3 SPTBN2 KIF3A APOB CTSC CAPZA3 ACTR10 TGFA PRKAB2 DCTN6 DCTN5 DCTN4 LRP2 PIP5K1C CHMP4C CHMP4B CHMP4A VPS28 TSG101 PRKAG2 VTA1 CHMP2B CHMP2A AP4M1 AP1G2 DNASE2 CLVS2 AP4S1 CLVS1 SEC13 VPS37C VPS37D VPS37A VPS37B CHMP3 WASL CHMP6 CHMP7 CHMP5 VPS4B VPS4A MVB12B MVB12A ANK1 MAN1A2 MAN1C1 MAN1A1 UBAP1 SBF1 SBF2 DENND5B RABGEF1 RINL TRAPPC12 TBC1D10C TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 TRAPPC2L SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 RAB35 TBC1D24 TBC1D25 ULK1 RAB38 CLTC DENND6B CLTA RIN3 AP2A1 DENND6A RIN1 AP2B1 RIN2 GABARAP AP2A2 TBC1D13 DNM1 TBC1D14 DNM2 TBC1D17 DNM3 AP2S1 RAB6B TBC1D15 SH3GL2 TBC1D16 TRAPPC2 TRAPPC3 TRAPPC1 ANKRD27 DENND4B CCZ1B DENND4A TRAPPC4 DENND4C HPS1 TRAPPC5 RAB39A CCZ1 RAB3IP HPS4 RAB27A RAB39B PRKAA2 RAB27B TRAPPC8 ARF4 TRAPPC9 MON1A MON1B PLA2G6 DENND1C INS DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D DENND2C DENND2B DENND2A CPD RAB3IL1 RAB33A RAB33B EXOC8 TRAPPC6A EXOC7 TBC1D2 RABEP1 PICALM TBC1D3 TRAPPC6B ARFGAP1 TBC1D7 RAB7B ARF6 EXOC4 RAB1A EXOC3 RABGAP1 EXOC6 RAB1B EXOC5 DENND3 EXOC2 RAB21 GGA2 EXOC1 GGA1 ALS2CL GGA3 ITSN2 CHML PREB RIC1 TRAPPC10 KDELR3 GBF1 RAB11B STX16 RGP1 RAB10 RAB11A GOSR1 TFRC GOLIM4 RAB12 RAB13 CYTH3 RAB18 PLA2G4A CYTH2 ITSN1 RAB41 RAB3GAP2 GOLGA5 RAB3GAP1 CYTH4 FNBP1L STX6 VTI1A CYTH1 COG8 COG7 COG6 COG5 COG4 FNBP1 COG3 COG2 BET1L RAB30 RAB36 GOSR2 DYNC1LI1 ALPP AGPAT3 DYNC1LI2 GJC1 GJC2 GJA3 MYO6 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 ARPC1A F5 F8 EGF EGFR YWHAE NEDD8 DYNLL2 LDLRAP1 ACTR1A SCARB2 AGFG1 VAMP3 KIAA0319 TOR1A GPS1 TOR1B SYT9 SYT8 SNAP91 AAK1 YWHAG STON1 RAB8A STON2 LMAN1 SLC2A8 SLC18A3 SGIP1 EPN2 VAMP4 STX5 FCHO1 YKT6 FCHO2 UBQLN1 REPS2 UBQLN2 REPS1 NECAP2 CSNK1D SYT11 DYNLL1 GJA1 UBA52 OPTN PAFAH1B1 DYNC1I2 AKT2 DCTN2 AKT3 DCTN3 UBB UBC AGTR1 RPS27A DYNC1H1 SAR1B COPS7B COPS7A BICD1 RHOBTB3 BICD2 GALNT2 PAFAH1B3 VPS36 PAFAH1B2 SFN SNF8 VPS25 DVL2 COPS3 COPS6 COPS5 GJB2 GJB1 ARPC4 ARPC5 COPS8 TACR1 COPS4 ARPC2 ARPC3 COPS2 SNAP23 MAP1LC3B ACTR3 ACTR2 ARFGAP3 ARFGAP2 GRK2 GNS USP6NL TJP1 SCOC SYS1 GCC1 ZW10 RAB43 GOLGA1 ARFIP2 RINT1 CFTR KDELR2 COPB2 COPA ARL1 COPE USE1 CHRM2 RABEPK TMED3 TMED7 SCFD1 TMED9 ADRB2 NAA30 COPZ2 COPZ1 SPTBN1 NAA35 STAM NAA38 ARF5 NBAS TMF1 ANK3 STX18 STX10 ARFRP1 VPS51 VPS53 VPS52 BNIP1 EPS15L1 VPS54 COL7A1 ARCN1 EPN1 COPG2 COPG1 PLIN3 RAB3A SYT1 SPTAN1 LDLR MAN2A1 CD3G CTTN RHOQ YWHAQ YWHAH DYNC1I1 SEC23A CD59 CD55 SEC24B TRIP10 SEC24A RAB9A RAB4A OCRL GALNT1 RAB9B EPGN AP4E1 ARRB1 CLINT1 M6PR AP1G1 VPS45 SYNJ2 SEC24D FTH1 AP1S2 SYNJ1 SEC24C AP1S1 AP1S3 RAB5A AP3S1 SH3D19 TPD52 AP1B1 PIK3C2A AP3B1 VAMP8 GAK DNAJC6 CALM1 FTL NAPA RAB5C BLOC1S4 TGOLN2 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 SNX9 SNX5 AP1M2 STAM2 TXNDC5 AP1M1 TBC1D8B SNAPIN SORT1 DTNBP1 HIP1R PUM1 TPD52L1 AP4B1 IGF2R NECAP1 GOLGB1 YIPF6 CTSZ ACBD3 RAB14 GRK3 WNT5A SYT2 FZD4 APP ALS2 CLTB TFG ARRB2 DAB2 CLTCL1 TF RAB5B AREG AVPR2 TRIP11 TMED2 SLC2A4 COG1 RAB6A BIN1 SNX18 RALGAPA2 RALGAPB C2CD5 MIA2 MIA3 TSC2 TSC1 AMPH HIP1 KIF28P PACSIN2 PACSIN3 SNAP29 PACSIN1 RAC1 ASPSCR1 TMEM115 KIF5C TBC1D1 KIF5B TBC1D4 KIF5A KIF21A KIF21B EREG KIFAP3 BTC KIF16B KIF20A KIF20B HBEGF KLC1 LNPEP KLC4 CBL KLC3 KLC2 KIF3B RACGAP1 KIF3C KIF18A MCFD2 KIF18B SERPINA1 KIF4B PPP6C KIF4A PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB TMED10 LMAN2L STX17 USO1 KIF12 MAN2A2 KIF11 NAPG LMAN2 SEC31B KIF15 ANKRD28 SEC16B KIF19 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins ATF1 ELK1 IL36RN RPS6KA3 RPS6KA5 CXCL8 RPS6KA2 IL7R CXCL1 JAK2 RPS6KA1 MAP3K8 MAP2K3 CXCL2 MEF2A MAP2K4 IL1RL2 MEF2C PIM1 TEC MAPKAPK3 CNTF MAPK9 MAPK8 MAP2K7 TOLLIP MAPK10 TNIP2 CCL11 IL10RB CCL3L3 CLCF1 CSF3 IL5RA CDC42 CCL5 CCL4 IL13RA2 CCL2 IL13RA1 CCR2 CCL19 CCR1 CAPZA1 CCL22 CCL20 IL1RN CXCL10 IL15RA IL1R2 STXBP2 PRTN3 COL1A2 LIF IL11RA IFNL2 IFNL1 NOS2 IFNL3 RALA PITPNA BOLA2B LMNB1 IL20RA CNN2 IL20RB HNRNPDL IL22RA2 CFL1 FASLG STAT4 TRAF2 IL12B IL22RA1 IL12A IL12RB1 CASP8 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 CTF1 MSN MIF SOD2 SOD1 VAMP7 TXLNA FSCN1 IFNG CD4 HNRNPF HNRNPA2B1 IL1RAPL1 PDCD4 PSME2 SNRPA1 PTPN9 LCN2 LCP1 PTPN5 PTPN2 PSMD12 PSMD11 PSMD14 PSMD13 ARF1 PSMA7 RPLP0 PSMB6 PSMD8 OSMR RORC PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 IL17C PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 IL7 ADRM1 PSMA5 SEM1 PSMA6 LYN PSMA3 DUSP4 PSMC5 CNTFR DUSP3 PSMA4 PSMC6 VRK3 DUSP6 DUSP7 VAMP2 PSMC3 ITGAX PSMA1 PSMA2 PTPN12 PSMC4 PSMC1 NFKBIA PSMC2 ATF2 PTGS2 HAVCR2 FOXO3 FOXO1 CSF3R AKT1 IGHE YWHAZ MAPKAPK2 NDN PTPN20 PTPN23 IL3RA PTPN14 S1PR1 CDKN1A HSPA8 STX4 IFNLR1 IL17RE MAPK14 IL17RB MAPK11 IL18RAP FOS MAP2K1 RAPGEF1 RBX1 IL2RA MAPK1 CRKL MAPK3 ICAM1 PTPN4 PIK3CD SOS1 IL21 P4HB VCAM1 ITGB2 GSDMD YES1 MAP2K6 VEGFA BCL6 IL2 IL3 SQSTM1 HSP90B1 JUNB BIRC5 IL18 IL1A IL1B STX1A PIK3R3 GSTO1 IL9 IL9R CCR5 TNFRSF1B CSF2 RORA BRWD1 IL23R IL23A CHUK PPIA IKBKB TP53 SNAP25 IKBKG PPP2R5D PPP2CA PPP2CB PPP2R1B TWIST1 ITGB1 GATA3 FGF2 LIFR TALDO1 LBP SMAD3 OPRM1 IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG HIF1A PTPRZ1 MYC JAK3 PIK3CA PTPN6 F13A1 TGFB1 CCND1 ALOX5 PPP2R1A CSF1R BTRC PRKACA RELA SKP1 HSP90AA1 FBXW11 INPPL1 NFKB1 IL6 UBA52 TBK1 MUC1 CUL1 SHC1 UBB AIP UBC RPS27A STAT3 BCL2 FCER2 PTPN7 CA1 IL34 BCL2L1 ANXA1 IL21R SDC1 PTAFR JAK1 RIPK2 PTPN13 LCK TYK2 SOS2 IL17RC SOCS5 IL17RA CANX MTAP CASP3 CTSG TIMP1 STAT1 STAT2 MMP1 HMOX1 MMP2 MMP3 IL17F MMP9 MAOA IL17A MAP3K7 LAMA5 INPP5D UBE2V1 IGHG4 IRAK1 IGHG1 IRAK2 VAV1 SYK HCK FPR1 FYN RHOU UBE2N TAB3 TAB2 TAB1 ALPK1 NLRX1 AGER S100A12 NANOG N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 PELI1 LRRC14 GAB2 TRAF6 USP14 PELI3 PELI2 IL33 NLRC5 CD86 USP18 TIFA IL32 CD80 S100B SAA1 NOD1 NOD2 SMARCA4 IL1RL1 PTPN11 ZEB1 HSPA9 FN1 CD36 H3C8 OPRD1 CSF2RB H3C15 CSF2RA GRB2 IL22 CISH IRS2 EBI3 IL27 IL6ST CRLF1 IL27RA SOCS2 SOCS1 IL6R POMC TCP1 APP NFKB2 ITGAM CASP1 SIGIRR IRAK3 PTK2B IL10RA RAP1B HGF VIM TNF MCL1 IL4R IL13 IRF4 CEBPD CCL3 STAT6 STAT5A TSLP STAT5B IL31RA IL1R1 IL18BP JUN STX3 POU2F1 PTPN18 CRLF2 SOX2 MAPK7 BATF IL4 IL5 GSTA2 IL2RB IL36A IL36B TNFRSF1A CRK LGALS9 CBL SOCS3 ALOX15 IL36G IL1F10 BLNK IL20 IL25 IL26 IL24 IL11 IL15 IL19 IL16 MAP3K3 IL31 CSF1 IL37 OSM IL18R1 RAG2 RAG1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 PITX2 TFAP2A TFAP2C LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC7 UBE2C CDKN1B UBE2E1 UBE2S CCND3 CDC16 CCND2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDKN1C SKP2 E2F2 CDK6 CCND1 CCNE2 CCNE1 CDK4 CDK2 TFDP1 TFDP2 RB1 ANAPC15 CDKN1A ANAPC16 UBE2D1 E2F1 ANAPC10 E2F3 ANAPC11 FZR1 CDC23 CDC26 CDC27 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi MAN1A2 MGAT1 MAN1C1 MAN1A1 MANEA REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression H2AC14 ERLIN2 CD274 CUL3 H2BC12L DERL2 OST4 RNF5 OSTC OS9 HIF1A STT3A MYC RNF185 STT3B B3GNT3 MYCN IRF1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 DDOST TNRC6A DAD1 TNRC6B CREBBP CCND1 H4C9 PRKAG2 H2AC20 PRKAA1 EZH2 H2AX NEK2 BTRC ASH2L DERL3 YWHAG DERL1 RELA SKP1 TEAD1 H3-3B TCF7L2 TEAD2 TEAD3 H3C8 TEAD4 NFKB1 ATF3 PDCD1LG2 JUND ERLEC1 H2AJ UBA52 PDCD1 FOSB CUL1 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 SUZ12 UBC LEF1 H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A BRD4 PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 RPN1 PSMB1 PSMD1 H2AB1 ADRM1 EP300 PSMA5 STAT3 SEM1 PSMA6 PSMA3 PSMC5 COPS5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 NFKB2 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 KMT2A KMT2C PRKAB1 MAGT1 JAK1 NFE2L2 CSNK2A1 GSK3B CSNK2A2 SEL1L DPY30 TCF7L1 PRKAG1 SPOP CSNK2B JUN H2BC26 PRKAG3 H2BC21 WDR5 PRKAA2 FOS EED STAT1 RBX1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 MIB2 TUSC3 H2BC11 EPAS1 TCF7 CDK4 TMEM258 RBBP4 RBBP5 PRKAB2 WWTR1 RBBP7 VCP H2AC19 YAP1 H2AZ2 ERLIN1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 MTFMT MTIF2 MTIF3 OXA1L MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 MRPL50 MRPS9 KGD4 MRPL51 AURKAIP1 DAP3 MRPS35 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation FGFR4 INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling IL23A STAT3 IL12RB1 P4HB JAK2 TYK2 STAT4 IL12B IL23R MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) MSH3 PCNA MSH2 PMS2 LIG1 RPA1 RPA2 MLH1 POLD3 EXO1 POLD1 POLD4 POLD2 RPA3 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling SYK RAP1A RAPGEF3 ITGB3 RAPGEF4 APBB1IP CRK PDPK1 SOS1 FGB FGA FGG RAP1B AKT1 SHC1 PTPN1 PTK2 BCAR1 VWF ITGA2B SRC RASGRP2 RASGRP1 CSK TLN1 FN1 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 TBP BRF2 BDP1 POLR1C POLR1D CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H GTF3C1 POLR3K GTF3C2 POLR2H GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR2K ZNF143 POLR2L BRF1 POU2F1 GTF3A NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism SMN2 NUP37 NUP107 NUP188 NUP210 NUP93 TGS1 NUP205 POM121 NUP214 DDX20 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 PHAX CLNS1A SNUPN NUP62 PRMT5 WDR77 NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP50 NUP54 GEMIN2 SNRPD2 SNRPD1 SNRPD3 NUP42 GEMIN4 SNRPG NUP43 GEMIN5 GEMIN6 SNRPE RAE1 GEMIN7 RANBP2 SNRPF GEMIN8 SNRPB NUP35 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism TNFAIP8L2 PI4KB PIKFYVE PIK3R2 SBF1 PIK3CB SBF2 PIK3R1 PIP5K1A PIP5K1B PIK3CA PIP5K1C BMX VAC14 PIK3C3 MTMR10 PITPNB MTMR12 PTEN MTM1 MTMR14 PTPN13 PIP4P1 GDPD1 GDPD3 OCRL RAB4A GDPD5 SYNJ2 PI4K2B SYNJ1 RUFY1 PNPLA7 PIK3R3 RAB5A GDE1 PIK3R6 PIK3R5 PIK3C2G PIK3C2A PIK3C2B SACM1L MTMR1 PNPLA6 PI4K2A MTMR2 INPPL1 MTMR3 INPP4A MTMR8 INPP4B MTMR9 ENPP6 MTMR4 TPTE2 MTMR6 MTMR7 TPTE FIG4 PIK3CD PIK3CG INPP5F INPP5D INPP5E INPP5J INPP5K PIP4K2A RAB14 ARF3 ARF1 PIP4K2B PIP4K2C PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 PIK3R4 TNFAIP8 TNFAIP8L1 TNFAIP8L3 PI4KA P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling VAV2 PSEN2 ARHGEF9 APH1A ARHGEF3 APH1B ARHGEF4 NGEF ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 MAPK8 ABR ARHGEF6 SORCS3 MYD88 SQSTM1 TRAF6 AATF MAGED1 CASP2 PSENEN YWHAE SMPD2 ARHGEF33 ARHGEF35 FGD1 ARHGEF37 FGD2 ARHGEF38 RELA FGD3 FGD4 ARHGDIA ARHGEF40 NFKB1 BEX3 MCF2 ARHGEF26 UBA52 ECT2 ARHGEF39 UBB UBC RPS27A ARHGEF10L MCF2L OBSCN ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 BCL2L11 ARHGEF17 ARHGEF16 BAD ARHGEF19 ARHGEF18 TIAM2 LINGO1 MAG ITGB3BP OMG NFKBIA RTN4 GNA13 RASGRF2 ADAM17 IKBKB PLEKHG2 RIPK2 PSEN1 PRKCI NCSTN NGF SOS2 TIAM1 PRDM4 CASP3 PLEKHG5 RAC1 RHOA SOS1 KALRN HDAC2 HDAC3 HDAC1 NET1 NGFR TRIO AKAP13 ITSN1 PREX1 VAV3 IRAK1 VAV1 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers BCL7C BCL7B DPF1 SS18 DPF2 BICRAL BICRA DPF3 BRD9 ACTL6A PHF10 SMARCC1 BCL11B SMARCC2 ARID1A ARID1B BCL11A BRD7 PBRM1 ACTL6B SMARCD1 SMARCD2 SS18L1 SMARCD3 SMARCA2 SMARCA4 SMARCB1 ARID2 PHF6 SMARCE1 ACTB BCL7A TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes MT-CO2 MT-CO3 G6PD RHEB COX7B GPX2 TXN TNRC6C YWHAQ TP63 MOV10 AGO3 YWHAH AGO4 COX7C PRKAB1 AGO1 RRAGA AGO2 RRAGC YWHAB RRAGB TNRC6A DDIT4 TNRC6B RRAGD MLST8 COX8A GLS2 AKT1 COX8C TP53 PRDX2 PTEN PRDX1 YWHAZ TXNRD1 CYCS YWHAE PRKAG2 COX5B PRKAA1 COX5A COX7A2 RRM2B COX7A1 MTOR GLS PRKAG1 YWHAG COX6C PRKAG3 RPTOR TSC2 TSC1 PRKAA2 COX6A1 COX6A2 COX7A2L TIGAR COX4I1 COX6B2 COX4I2 COX6B1 AKT2 AKT3 COXFA4 GPI LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SESN3 SESN2 MT-CO1 HIGD1C PRKAB2 SLC38A9 SCO2 SFN CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition BORA PPP2R1B CDC25A CDC25B SGO1 PPP2R3B FOXM1 PKMYT1 XPO1 CCNB2 WEE1 CCNB1 CDK2 CCNA2 CCNA1 HJURP CDK7 MIS18BP1 PPP2R2A MNAT1 CDC25C OBI1 PPP2R1A LCMT1 PPME1 TICRR PLK1 CCNH CDK1 PPP2CA FZR1 PPP2CB METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals MT1M MT1X MT2A MT1A MT1F MT1G MT1H MT1B MT1E MT4 MT3 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle VAV2 PIK3R1 CAV1 SHMT2 IQGAP2 ARHGEF5 MAP3K11 MCAM DOCK2 CDC42 PGRMC2 HSPE1 ARHGAP1 PLEKHG3 PAK4 LETM1 EMD ARFGAP3 MPP7 DSG2 ESYT1 CDC42EP1 VAMP3 ARHGDIG ARHGAP39 ARHGAP5 LMAN1 ARHGAP21 ARHGDIA NDUFS3 ARHGDIB STX5 LBR YKT6 ERBIN RAB7A ARHGAP35 MCF2 LEMD3 PLD1 ARHGEF26 KTN1 OPHN1 TMPO VANGL1 DEPDC1B PAK2 ELMO2 ITGB1 DOCK1 EPHA2 GARRE1 KALRN LAMTOR1 VAPB CYFIP1 ARHGAP32 ANKLE2 TRIO TFRC DIAPH3 ITSN1 STBD1 VRK2 DOCK5 DOCK4 DOCK3 MCF2L PREX1 VAV3 RHOG ARHGEF16 VAV1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism PRODH2 PRODH ALDH4A1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 MALSU1 MIEF1 MTRFR MTRES1 OXA1L NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 MRPL50 MRPS9 KGD4 MRPL51 AURKAIP1 DAP3 MRPS35 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins CALM1 SV2C SV2B SV2A VAMP1 CD9 VAMP2 MAP2K4 MAP2K1 PDCD6IP MAP2K2 MAP2K7 HSP90AB1 HBEGF SNAP25 FURIN TXNRD1 GUCY2C EEF2 NHERF4 SYT1 STX1B STX1A SYT2 HSP90AA1 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL PSMA5 CUL3 SEM1 DVL1 PSMA6 DVL2 PSMA3 PSMC5 DVL3 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 HECW1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC KLHL12 PSMA7 DACT1 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) OPRK1 CXCL6 MC4R CXCL9 CXCL8 EDNRB CXCL1 CXCL13 CXCL3 EDN1 CXCL2 CX3CL1 EDN3 CXCL5 CXCL16 CCRL2 CCR9 CCR8 MC3R CCR7 CCR4 CCR3 MC1R CCL13 CCL11 MC5R CCL3L3 CXCR5 NPFFR2 CXCR6 NPFFR1 CCL7 NPFF CXCR1 CCR6 QRFPR CCL5 HCRT CXCR3 QRFP CCL4 CXCR2 HCRTR2 CCL2 HCRTR1 CCR2 CCL1 CCL19 F2R F2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 PPBP CXCL10 KNG1 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 CCL27 HCAR2 HCAR3 HCAR1 LHCGR TSHR FSHR GPHA2 GPHB5 CXCL12 AGT CHRM3 OXTR GRPR EDNRA PROK2 OPN1LW PROK1 UTS2R TRHR PDYN UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 NTSR1 NTSR2 GPR17 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 MLN PSAP BRS3 DRD1 DRD2 GPR132 DRD3 ADRA2B CCKAR DRD4 GNRHR DRD5 FFAR4 FFAR3 CX3CR1 FFAR2 GPR39 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R AVPR1B P2RY10 P2RY11 AVPR1A GPR4 ADRA2C ADORA2A GPR143 ADORA3 ADRA2A MT-RNR2 ADORA1 F2RL1 F2RL2 AVP F2RL3 CHRM1 GPR68 GPR65 PMCH CHRM5 GHSR LTB4R2 S1PR1 UTS2 NTS MCHR2 HRH1 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR HTR2B HTR2C OXT HTR2A TRH LTB4R BDKRB2 BDKRB1 GNRHR2 XCL2 SST XCL1 CGA P2RY6 P2RY2 P2RY1 CCK KISS1 CHRM2 CHRM4 ADRB1 ADRB2 HTR4 HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A HTR1B TAAR5 TAAR2 HTR5A TAAR1 ADRB3 CYSLTR1 CYSLTR2 RXFP4 MRGPRD FFAR1 RXFP1 RXFP2 RXFP3 CMKLR1 ADORA2B AGTR2 FPR1 FPR3 C3 GALR3 OPN1SW GALR2 GALR1 NPBWR1 NPBWR2 OPN1MW GPR183 PNOC GPR18 C5AR2 C5AR1 C5 GPR37 GPR35 GPR31 RGR PLPPR1 PLPPR2 SAA1 PLPPR3 PLPPR4 PLPPR5 P2RY12 C3AR1 P2RY13 P2RY14 GPR55 ADRA1D ADRA1B ADRA1A MTNR1A TBXA2R MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 P2RY4 APLN RRH OXER1 PTGDR CCR5 GPR37L1 KEL NLN PENK PPY PTGDR2 OXGR1 GPBAR1 GAL PTGER4 OPRD1 NPB TSHB FSHB PTGER2 PTGER3 CXCR4 NPW PRLH MAS1 XK MC2R PF4 NPY2R NPY1R APLNR SUCNR1 OPN3 OPN5 PYY HEBP1 POMC APP GPER1 PTGIR NPY5R SSTR1 LHB SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 CNR2 CNR1 S1PR3 S1PR2 S1PR5 S1PR4 ACKR1 AVPR2 CCL3 MCHR1 NPY SSTR3 RHO OPRM1 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses GLB1 SGSH NAGLU IDS GUSB IDUA ARSB HGSNAT GNS GALNS HYAL1 NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response PSMA5 CUL4A SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 DCAF8L1 DCAF8L2 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 CUL4B PSMC2 RBX1 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 BARD1 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 DDB1 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BRCA1 ADRM1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants BRAF SHOC2 PPP1CC MRAS YWHAB RAF1 PPP1CB ARAF MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement CLU C8A C8G C5 C6 C7 C9 C8B DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) EPOP ERCC3 KANSL1 SCD KANSL2 KANSL3 ERCC2 THRSP SRRT ERCC6 ZNF610 MEF2C IPO8 SPI1 ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 ZNF705EP DDIT3 ZNF274 ZNF20 ZNF23 ZNF25 ZNF26 GRIN2A ZNF268 ZNF267 ZNF266 ZNF263 CTR9 ABCA6 RTF1 NR2F1 ZNF34 GRIN2B SYMPK NR0B2 NR2F6 COL1A1 PAF1 COL1A2 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 HEY1 ZNF41 HEY2 CTLA4 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 ZNF480 ZNF479 ZNF235 ZNF234 ZNF233 ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT BGLAP CSTF2T ZNF227 ZNF468 ZNF226 ZNF225 ZNF223 ZNF222 ZNF221 CLP1 ZNF461 ZNF460 ATAD2 ZNF77 ZNF79 SKI ZNF70 ZNF71 ZNF74 AGRP PSMD12 ZNF699 PSMD11 ZNF215 NOTCH1 ZNF214 PSMD14 ZNF213 PSMD13 ZNF697 LEF1 RBPJ ZNF696 ZNF212 DLL1 PSMA7 ZNF211 ZNF692 PSMB6 ZNF691 PSMD8 UBE2D3 RORC PSMB7 RORB PSMB4 ZNF208 PSMD6 ZNF205 PSMB5 ZNF689 PSMD7 ZNF688 PSMB2 ZNF446 PSMB3 ZNF445 PSMD2 PITX2 PSMD3 ZNF202 PSMB1 ZNF443 PSMD1 ZNF200 ZNF684 ZNF442 ZNF441 ZNF682 ADRM1 ZNF440 PSMA5 ZNF681 ZFP69B SEM1 PSMA6 FOXP3 PSMA3 NPAS4 SIRT3 PSMC5 ZNF439 PSMA4 ZNF679 PSMC6 ZNF678 ZNF436 PSMC3 ZNF677 PSMA1 ZNF676 PSMA2 ZNF433 PSMC4 ZNF675 PSMC1 ZNF432 PSMC2 PVALB ZNF431 CTNNB1 ZNF430 BLK GRIA2 ZNF671 ZNF670 MAX DLX6 PCF11 FOXO6 FOXO4 FOXO3 FOXO1 ZNF840P ATXN3 YWHAB MOBP ZKSCAN7 ZNF429 ZKSCAN8 XPO1 ZKSCAN3 AKT1 ZNF668 ZNF426 ZNF667 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 YWHAZ ZKSCAN1 SOCS4 ZNF662 ZNF660 FBXO32 ZNF419 ZNF417 ZNF658 ZNF416 ZNF415 STK11 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 MAPK14 PPM1A MAPK11 HAND2 ZNF875 ITGA5 PPM1D ZNF627 ZNF626 GLI3 ZNF625 GLI2 ZNF624 ZNF621 E2F5 ZNF620 E2F6 ZNF860 MGA TBX5 PINK1 ZNF619 RBX1 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 TSNAX STUB1 TSN ZNF611 COX4I1 PTPN4 COX4I2 TRIM33 UXT LGALS3 ZNF729 ZNF727 ZNF726 ZNF724 CCN2 ZNF721 ZFP1 ZFP2 ZNF718 ARNT ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 ITCH ZNF324B L3MBTL2 FOXG1 TGFA ZNF709 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 GTF3C1 ZNF700 GTF3C2 WWTR1 GTF3C3 YES1 GTF3C4 IQSEC3 GTF3C5 ITGBL1 GTF3C6 MSTN HNF4G BRF1 YAP1 GTF3A SATB2 ZFP14 ZNF585B RXRG ZNF585A GAD1 GAD2 VEGFA CCNG2 ZFP28 PRDM7 IHH CCND3 CCND2 NPPA MSX2 CCNK ZNF99 CCNT2 GEM ZNF92 CCNT1 GPRIN1 ZFHX3 AUTS2 GTF2B IL2 IL3 BMP2 TCF3 SUPT16H LDB1 MYBL2 TGIF1 ZNF75CP GTF2F1 RBM14 GTF2F2 TGIF2 ELF1 ELF2 CAT RETN ZNF804B ZNF175 SERPINE1 SUPT4H1 ZSCAN32 JUNB NEDD4L ZNF169 RNF111 GTF2E1 ZNF705G GTF2E2 ZNF705D ZNF160 ZNF705A ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 NKX2-5 NR2C2AP ELOA2 ZNF383 ZNF140 SUPT5H CDC7 NR1D2 CDK9 ZNF37A ZNF702P ZNF138 TAF4B ZNF135 ZNF133 RARG BTG1 ELL TAF7L RSPO3 TEAD1 ELOA ZNF124 NELFB TEAD2 ELOB ZIK1 NELFCD TEAD3 NELFA TEAD4 ELOC TCF12 PAX5 NELFE TAL1 SLBP RARB ZNF599 ZNF114 NCBP1 ZNF597 ZNF596 NCBP2 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 GTF2A1 ZNF583 GTF2A2 CTDP1 ZNF582 RNMT PCGF6 CDKN2B TAF9 PCGF5 PCGF2 WWP1 TAF1L ZNF33B RYBP POLR2A ZNF337 POLR2B ZNF577 ZNF334 POLR2C ZNF333 POLR2D PF4 ZNF573 RXRB ZNF571 POLR2G CSF2 ZNF570 POLR2I TAF9B ITGA2B ZFP30 POLR2J ZNF569 ZNF568 ZNF567 ZNF566 RNGTT TAF15 ZNF565 TAF12 ZFP37 TAF13 ZNF564 TAF10 ZNF563 TAF11 IGFBP1 SSRP1 ZNF562 TAF8 ZNF561 ZNF560 TAF7 NRBP1 ZNF559 TCEA1 ZNF558 TAF6 ZNF557 TAF5 ZNF799 TAF4 ZNF556 TAF3 ZNF555 RAN ZNF554 TAF2 ZNF311 ZNF552 TAF1 ZNF793 G6PD ZNF551 ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL PLXNA4 ZNF300 ZNF782 ZNF540 ZNF658B ESRRB ESRRG ZFP69 CDK6 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 CYCS ZNF770 FKBP5 ZNF529 ZNF528 ZNF764 ZNF521 ZNF761 CR1 ZNF75D ZFP90 ZNF75A ZNF517 CRH ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 AXIN1 ZNF747 ZNF746 ZNF500 ZNF740 PPP2R5C KCNIP3 PPP2CA KLF4 PPP2CB RAD51 ZNF738 ZNF737 ZNF736 PPP2R1B ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 ZNF605 SOX9 ZNF600 ZNF839 INS TWIST2 TWIST1 ZNF726P1 OCLN CITED1 CITED2 CITED4 PARP1 KRABD5 KRABD4 KRABD3 GP1BA RET ZNF2 ZNF3 NPY CAMK4 GATA3 ZNF354C ZNF354B LMO1 LMO2 ATP1B4 LIFR KCTD6 NOP2 SMAD2 SMAD1 SMAD4 SMAD3 HNF4A PIP4K2A SMURF2 SMURF1 SMAD6 ESR2 PIP4K2B SMAD7 NR4A1 PIP4K2C NR4A3 JAG1 THRA CGB8 NR2E1 YBX1 OPRM1 CAMK2B ZNF197 CAMK2D TDRKH ZNF195 PIWIL2 CAMK2A PIWIL1 NR2C2 HENMT1 THBS1 ASZ1 HSPD1 MED8 MAEL HES1 MOV10L1 CAMK2G MYBL1 ZNF189 TDRD9 ZNF286A TDRD6 ZNF184 TDRD1 ZNF180 TDRD12 OPRK1 FKBP6 PRDM1 MYC ELAC2 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 PIP4P1 CRCP TFAP2A POLR3GL TFAP2B POLR3A WWOX POLR3B TFAP2C POLR3C TFAP2D POLR3D TFAP2E POLR3E POLR3F KCTD1 KCTD15 POLR3G CSF1R POLR3H CEBPB POLR3K ANAPC15 ANAPC16 UBE2D1 ANAPC10 RELA ANAPC11 FZR1 CDC23 CDC26 CDC27 VENTX TCF7L2 ANAPC7 UBE2C CDKN2A UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 AKT2 AKT3 SNRPD3 SFN ESRRA GPX2 GLS2 PRMT1 TXNRD1 STAT1 COX7A2L TJP1 SNRPG SNRPE SNRPF SNRPB BCDIN3D TARBP2 PRKRA IRAK1 XPO5 DROSHA CAV1 YWHAQ YWHAH PDPK1 ARNT2 BMAL1 PTPN11 COX7A2 COX7A1 CALM1 SLC2A3 ANG CCNE2 CCNE1 POMC NLRC4 CASP1 TXNIP SKP2 MET MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 E2F1 TCF7L1 DLX5 JUN SOX2 SNW1 MAMLD1 MYB TSC2 TSC1 CDKN1B ZFPM1 GATA4 GATA2 GATA1 SOCS3 PTPN1 NFE2 CDK4 CDK2 TRPC3 MTERF1 TFAM TNFRSF10B FASLG TNFRSF10A TFB2M FAS POLRMT SOD2 IFNG PRKCQ PLK2 MDC1 ATF2 TP53RK NOC2L TP53AIP1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 RHNO1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 NUAK1 PCBP4 PRDX1 TP53BP2 ATRIP PRELID3A BANP BARD1 PLK3 PRELID1 CRADD GADD45A TPX2 RAD17 ATM CDK12 CDK13 ATR TP73 CDKN1A BTG2 BDNF SETD9 PRKAG1 CDK5R1 CHM BRCA1 GCK PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 RMI2 BRD1 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D SGK1 PCNA WRN MAPK1 PLAGL1 PERP PMS2 MAPK3 RICTOR BRD7 TIGAR NPM1 RPA1 RPA2 MLH1 HIPK1 POU4F1 EAF1 POU4F2 EAF2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CCNA2 STEAP3 CCNA1 MRE11 SESN3 SESN2 MT-CO1 NBN KMT5A BNIP3L USP7 IGFBP3 SUPT6H USP2 CDC25C MSH2 FANCD2 PRKAB2 AFF4 KAT6A MAPKAPK5 BLM NDRG1 SMYD2 SLC38A9 BCL2L14 MAP2K6 ZNF420 MLLT1 MLLT3 FANCI BRPF1 IWS1 SCO2 BRPF3 TNFRSF10C FANCC MT-CO2 CNOT10 TNFRSF10D MT-CO3 CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 RHEB CNOT2 CNOT3 JMY MDM2 PIN1 MDM4 CNOT8 RAD9B CNOT9 RAD9A PRR5 PPP1R13B DYRK2 TRIAP1 PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA PRKAG2 RBL2 RBL1 MED15 BIRC5 TMEM219 PRKAA1 RNF34 AURKB TP53INP1 RBBP8 E2F4 RFFL E2F7 E2F8 ARID3A MTOR PML RAD50 BAX MED26 HDAC10 EPC1 MED25 DICER1 PABPN1 PPARD PRMT6 PBRM1 ACTL6B YEATS4 ARID2 HDAC4 THRB UBE2I VDR NR1H2 RORA NR3C1 ESR1 KDM5B NR2C1 NR5A1 NR4A2 AR G6PC1 RXRA SUMO1 SP1 SUMO2 RARA PPARG PGR PPARA HDAC8 TP53 REST PTEN DGAT2 CSNK2A1 CSNK2A2 RRM2B DDX4 CSNK2B PRKAA2 PLD6 KIT BRIP1 APOE PCK1 MGLL PRKCB AGPAT2 RRN3 MYL9 COX7B COX7C GPAM COX8A SREBF1 COX8C LPIN1 PNPLA2 ERBB2 EGFR YWHAE COX5B COX5A PPP2R1A PRKACA COX6C YWHAG PHF6 SKP1 HSP90AA1 COX6A1 COX6A2 USP9X UBA52 AJUBA COX6B2 COX6B1 CPAP CUL1 AURKA CCNB1 UBB UBC HIGD1C RPS27A CDK1 BCL2L11 PMAIP1 BID BBC3 RRM2 CARM1 SRC SRF GLS CTSV NAMPT GAMT CTSL CTSK SSB NFIX NFIA NFIB NFIC CGA NR1D1 MMP13 GPI FURIN SPP1 RB1 SMARCB1 CCNH EHMT2 H2AC19 EHMT1 CCNC RRP8 ACTB LIPE H2AC14 TRIM28 H2BC12L SAP130 DPF1 PDK4 DPF2 KAT8 DPF3 MED1 SAP30BP SMARCC1 SMARCC2 ACSL1 MED4 HCFC2 MED6 MED7 HCFC1 WDR82 ZNF28 PAXIP1 ZNF273 PEX11A BAZ2A ZNF708 PPARGC1A PPARGC1B KAT14 ZNF264 CREBBP ZNF141 H4C9 SETDB1 ZNF382 SETD1B SS18L1 SETD1A SMARCA5 CAVIN1 SMARCA2 CIDEC SMARCA4 TADA2A ZZZ3 ZNF816 H2AC20 ZNF30 ZNF136 ZNF257 EZH1 EZH2 H2AX PHF20 SUV39H1 PHF1 ASH2L SGF29 MED16 MED17 MED12 MED14 MED13 MED10 CD36 JARID2 H3-3B NCOA1 NCOA2 LBR H3C8 SS18 ELOVL5 NCOA6 NUDT21 NCOA3 ACTL6A TET2 TET1 PPHLN1 BAZ1B MED27 SIRT1 MED23 NCOR2 PHF20L1 KAT2B KAT2A H2AJ MED24 NR5A2 NCOR1 AEBP2 TET3 MED20 MTF2 PLIN4 PLIN2 ANGPTL4 PLIN1 CPSF7 GPS2 H3C15 TBL1X SF3B1 ZNF224 MBD3 SUZ12 H2BC9 H2BC8 H2BC5 MCRS1 H2BC3 MBD2 H2BC1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GATAD2B GATAD2A ZNF33A FABP4 MYBBP1A ZNF354A MPHOSPH8 ZNF454 ZNF331 H2AB1 ARID4B TTF1 EP300 MTREX ZNF324 PHLDA1 MEN1 ZNF320 H2AC8 ZNF680 H2AC6 H2AC7 ADIPOQ SAP30 SPOCD1 ZNF93 TBL1XR1 ZNF317 ZCCHC8 KMT2D BRF2 BDP1 DNMT1 KMT2A TXN KMT2C KMT2B BOD1L1 WDR33 LPL MED30 MED31 TASOR MBIP ZNF669 ABL1 PAPOLA TASP1 ZNF547 ZNF425 SUDS3 MORC2 HDAC11 RAMAC DR1 BMI1 LSM10 CBX5 LSM11 BOD1 YY1 INTS1 CBX3 INTS3 EZHIP INTS2 CDK8 RING1 INTS5 CDK7 INTS4 CDK5 MAF INTS7 YEATS2 SKIC8 ZNF418 INTS6 INTS9 TADA3 HDAC5 INTS8 ZNF778 FIP1L1 INTS11 ZNF534 HDAC9 MNAT1 INTS12 RNF2 OGT INTS13 HDAC6 INTS14 PHF19 HDAC7 INTS10 GSK3B PIWIL4 ICE1 AKAP8L ICE2 SSU72 PSIP1 NABP2 DPY30 CBX8 NABP1 CHD4 CHD3 PHAX PHC2 ZNF143 PAGR1 CBX6 PHC1 ELL2 DNMT3L H2BC26 ELL3 POU2F1 ZC3H8 SIN3B CBX4 BCL7A RPRD2 CBX2 NFATC2 SIN3A CSTF3 RPAP2 ZNF649 CSTF2 RPRD1B H2BC21 NFYA RPRD1A POU2F2 BCL7C PHC3 NFYB SNAPC5 BCL7B SNAPC1 DNMT3B CSTF1 SNAPC2 UBTF NFYC SNAPC3 WDR5 SNAPC4 ZNF765 RBM7 KDM6A TBP EED DNMT3A ARID1A H2BC17 ARID1B H2BC12 H2BC13 H2BC14 H2BC15 ZNF519 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E CPSF4 POLR1F POLR1G CPSF1 CDC73 POLR1H CPSF3 CEBPA COXFA4 CPSF2 C19orf84 SMARCD1 ACSS3 HDAC2 SMARCD2 HDAC3 TCF7 SMARCD3 UHRF1 LEO1 HDAC1 CXXC1 DDX21 TAF1D MTA1 TAF1B RBBP4 TAF1C RBBP5 TDG SAP30L TAF1A POLR2E POLR2F SAP18 POLR2H RBBP7 MTA2 MTA3 POLR2K POLR2L ATF7IP SMARCE1 H2AZ2 DEK ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria DYNLL1 MAPK8 BCL2L11 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling IRS2 IRS1 NRAS SOS1 HRAS AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation GLYATL3 GLYATL2 GLYATL1 ACSM1 GLYAT ACSM2A ACSM5 ACSM4 ACSM2B BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDHA BCKDHB BCKDK DLD DBT REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation IKBKE UBB UBA52 TBK1 UBC TANK OPTN TLR3 TRAF3 RPS27A TICAM1 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms NOXA1 DVL1 DVL2 NOXO1 DVL3 FZD7 CYBA RAC1 WNT5A NOX1 JUN MAPK8 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants FLT3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 OVGP1 B4GALT1 SPAM1 ZP1 ZP3 ZP2 ZP4 ADAM21 ADAM20 ADAM30 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR MSH6 MSH3 PCNA MSH2 PMS2 LIG1 RPA1 RPA2 MLH1 POLD3 EXO1 POLD1 POLD4 POLD2 RPA3 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) PTGR1 CYP1A1 ALOX15 ALOX12 CYP2C9 CYP2C8 ALOX5AP CYP2D6 EPHX2 ALOX5 CYP1A2 CYP2E1 CYP3A4 PTGS2 HPGD LTA4H GSTM4 LTC4S MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) TLR6 LY96 TIRAP TLR1 S100A1 S100A9 BTK CD14 S100A8 MYD88 TLR2 HMGB1 TLR4 FGB FGA FGG CD36 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) BCL7C BCL7B DPF1 SS18 DPF2 DPF3 ACTL6A PHF10 SMARCC1 BCL11B SMARCC2 ARID1A ARID1B BCL11A ACTL6B SMARCD1 SMARCD2 SS18L1 SMARCD3 SMARCA2 SMARCA4 SMARCB1 SMARCE1 ACTB BCL7A RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling MAPK7 DOK4 PIK3R2 DOK5 DOK6 PIK3CB PIK3R1 PRKACG PRKACB SHC3 FRS2 DOK1 RAP1GAP PIK3CA SHANK3 GRB10 RET PDLIM7 GRB7 PIK3CD SOS1 GAB2 NRTN SHC1 PSPN GAB1 GFRA2 DOK2 GFRA4 ARTN PRKCA PLCG1 PTPN11 IRS2 GFRA1 PRKACA PIK3R3 GDNF GFRA3 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis FAR1 AWAT2 FAR2 AWAT1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins ST3GAL1 ST3GAL2 ST3GAL3 B3GNT7 B3GNT5 B3GNT4 B3GNT3 ST6GALNAC2 B3GNT2 ST6GALNAC3 ST6GALNAC4 GALNT1 C1GALT1C1 MUC13 MUC12 MUC15 MUCL1 MUC3A MUC5AC MUC3B MUC1 GALNT11 MUC2 GALNT14 GALNT13 GALNT16 MUC7 GALNT15 MUC4 GALNT18 MUC6 GALNT17 MUC16 GALNT10 GALNT3 MUC17 MUC19 C1GALT1 QTGAL MUC5B MUC20 GALNTL5 MUC21 ST6GAL1 GALNTL6 GALNT9 GALNT8 B3GNT9 B4GALT6 B3GNT8 B3GNT6 B4GALT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT ST3GAL4 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation KCNE4 KCNE5 AKAP9 KCNA5 KCNQ1 KCNH2 KCNE1 KCNE2 KCNE3 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses EP300 ELOB IFNA21 ELOC MAVS IFNB1 STAT2 RBX1 IFNA5 IFNA4 UBA52 IFNA7 IFNA6 IFNA1 IFNA2 CUL5 IRF3 IFNA8 IFNA14 CREBBP IFIH1 IFNA16 JAK1 TRIM25 IFNA17 UBB RIGI UBC TYK2 RPS27A EIF2AK2 IFNA10 IFNAR1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors TFAP2D CITED2 EP300 TFAP2E CITED4 YEATS4 TFAP2A TFAP2B WWOX CREBBP TFAP2C CITED1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria AUH DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 LFNG FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization VAV2 SYK TEC PLCG2 AHCYL1 PLCG1 TXK CALM1 GRAP2 LCP2 NFATC3 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 ITK IGKV2D-28 IGKV4-1 IGHV7-81 ITPR1 V1-11 ITPR2 IGKV2D-30 V1-16 V1-13 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 PPP3R1 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 PPP3CA IGLV1-51 PPP3CB IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 NFATC2 NFATC1 BTK SOS1 VAV3 VAV1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands HEBP1 SAA1 APP ANXA1 FPR1 MT-RNR2 FPR3 FPR2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA AURKA PHLDA1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACOT2 ACOT1 ACSF2 DBI THEM5 THEM4 ACADVL ACOT11 ACOT12 ACOT13 PCCA MMAA PCCB MCAT HADH ECI1 ACADL ECHS1 ACADM ACADS ACOT7L PCTP ACAD11 ACAD10 MCEE MMUT ACOT9 MECR ACSM3 ACOT7 HADHB HADHA DECR1 ACSM6 ACBD7 ACAA2 ACBD6 NDUFAB1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 REL NFKBIA PSMC1 PSMC2 NFKBIE NFKBIB CHUK IKBKB IKBKG MALT1 BTRC RELA SKP1 FBXW11 NFKB1 UBA52 MAP3K7 CUL1 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 CARD11 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 BCL10 PSMD3 PSMB1 PSMD1 PRKCB ADRM1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2AC14 TDRD1 TDRD12 H2BC12L FKBP6 RAN H2AC8 H2AC6 H2AC7 IPO8 ELAC2 TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B H4C9 H2AC20 H2AX PIWIL4 DGCR8 DDX4 H2BC26 HSP90AA1 H2BC21 H3-3B H3C8 PLD6 DICER1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TSNAX TSN H2AJ ANG H2BC11 H3C15 POLR2A POLR2B POLR2C POLR2D H2BC9 H2BC8 POLR2G H2BC5 POLR2I H2BC3 POLR2J H2BC1 POLR2E POLR2F TDRKH POLR2H PIWIL2 PIWIL1 HENMT1 BCDIN3D H2AC19 ASZ1 POLR2K TARBP2 MAEL POLR2L PRKRA XPO5 MOV10L1 H2AB1 MYBL1 DROSHA H2AZ2 TDRD9 TDRD6 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m DOLK ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI PLBD1 PLA2R1 PLA2G4F PLA2G12A PLA2G5 PLA2G2F PLA2G4D PLA2G2D PLA2G4E PLA2G2E PLA2G4C MBOAT7 PLA2G4A PLA2G2A PLAAT3 PLA2G10 PLA2G1B IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs JAK1 MAPK3 JAK2 IFNGR1 IFNGR2 IFNG RAF1 MAPK1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction NEB TMOD3 MYH3 MYH8 MYH6 TTN TNNI1 TNNI2 ACTN3 TNNI3 DES ACTN2 MYL4 VIM MYL1 MYL2 MYL3 DMD MYBPC3 MYBPC1 MYBPC2 TNNC1 TPM4 TNNC2 TNNT1 TPM3 TNNT2 TNNT3 TCAP TMOD1 TMOD4 TPM2 TPM1 TMOD2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 MSH2 MSH6 MSH3 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV GYG2 GYS2 GBE1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR PIGU PGAP1 PIGT PLAUR GPAA1 PIGS PIGK CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC5A9 SLC60A2 SLC5A4 SLC2A14 SLC2A11 SLC2A10 SLC2A12 SLC5A10 SLC2A9 FGF21 SLC45A3 SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A6 SLC2A7 SLC50A1 SLC5A1 SLC5A2 SLC2A8 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling LCAT PCSK5 LMF2 LMF1 LIPC ALB ANGPTL8 ANGPTL3 FGF21 APOA2 APOF APOA1 LPA MBTPS1 APOA4 APOA5 MBTPS2 LPL GPIHBP1 ANGPTL4 MTTP P4HB APOB FURIN APOC3 CREB3L3 APOC2 PCSK6 APOE CETP ABCG1 LIPG MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase DYNC1LI1 DYNC1LI2 CDCA8 SKA1 SKA2 KIF2A KIF2C PTTG1 KIF2B CENPE NUF2 EMD NUDC DYNLL2 PPP2R2A INCENP TUBA1A PPP2R1A ANAPC15 ANAPC16 CENPA UBE2D1 ANAPC10 CENPC ANAPC11 CDC23 CDC26 CDC27 VRK1 LEMD2 CDCA5 ANAPC7 PDS5B PDS5A UBE2C WAPL CENPT UBE2E1 ESPL1 CENPU UBE2S CDC16 LMNB1 ANAPC4 ANAPC5 SMC3 ANAPC1 DYNLL1 ANAPC2 RAD21 CKAP5 CENPF TUBA4A STAG1 STAG2 CENPH MAPRE1 CENPI SMC1A UBA52 TAOK1 CENPK PAFAH1B1 CENPL CENPM DYNC1I2 CENPN CENPO CENPP CENPQ CCNB2 CENPS PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 CLASP1 PSMB7 PSMB4 PSMD6 DYNC1H1 PSMB5 PSMD7 PSMB2 NDE1 PLK1 PSMB3 PSMD2 TUBB4B CLIP1 PSMD3 TUBB4A PSMB1 PSMD1 MAD1L1 CDK1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 NDC80 RPS27 PSMC2 XPO1 SPDL1 TNPO1 NSL1 KPNB1 KNL1 ZW10 DSN1 RCC2 BUB1B CDC20 ZWINT BUB3 AHCTF1 MAD2L1 NDEL1 NUP107 NUP188 MIS12 RCC1 PPP1CC BANF1 NUP93 CHMP4C CHMP4B DYNC1I1 CHMP4A NUP205 POM121 NUP160 NUP85 BIRC5 B9D2 SPC24 NUP155 AURKB SPC25 ERCC6L ZWILCH CHMP2B CHMP2A NUP62 KNTC1 LBR NDC1 SEC13 SGO1 SGO2 NUP133 TUBB6 TUBB3 TUBB1 RANGAP1 PMF1 CHMP3 NUP54 CHMP6 CHMP7 TUBA4B VPS4A NUP43 RANBP2 TUBB8 SPAST IST1 TUBB8B CC2D1B TUBA8 TUBA1C TUBA1B NUP35 RAN TUBB2B TUBB2A NUP37 UBE2I ITGB3BP TUBAL3 TUBA3E TUBA3D TUBA3C SUMO1 BUB1 CLASP2 SIRT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E LEMD3 KIF18A ANKLE2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 UPF1 RPS3A RPL3L RPL37A RPL23A GSPT2 GSPT1 RPL36A ETF1 RPL35A PABPC1 RPL22L1 RPS27L RPL10 RPS15A EIF4G1 RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 NCBP1 NCBP2 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L RPLP1 RPLP0 RPL38 RPS27A RPL37 RPL39 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors OPRK1 CXCL6 MC4R CXCL9 CXCL8 EDNRB CXCL1 CXCL13 CXCL3 EDN1 CXCL2 CX3CL1 EDN3 CXCL5 CXCL16 CCRL2 CCR9 CCR8 MC3R CCR7 CCR4 CCR3 MC1R CCL13 CCL11 MC5R CCL3L3 CXCR5 NPFFR2 CXCR6 NPFFR1 CCL7 NPFF CXCR1 CCR6 QRFPR CCL5 HCRT CXCR3 QRFP CCL4 CXCR2 HCRTR2 CCL2 HCRTR1 CCR2 CCL1 CCL19 F2R F2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 PPBP CXCL10 KNG1 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 CCL27 CXCL12 AGT OXTR GRPR EDNRA PROK2 PROK1 UTS2R TRHR PDYN UTS2B AGTR1 FPR2 NTSR1 NTSR2 NMB XCR1 NMBR NMS NMU MLN PSAP BRS3 CCKAR CX3CR1 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R AVPR1B AVPR1A MT-RNR2 F2RL1 F2RL2 AVP F2RL3 PMCH GHSR UTS2 NTS MCHR2 TAC3 TAC1 NMUR2 NMUR1 MLNR OXT TRH BDKRB2 BDKRB1 XCL2 SST XCL1 CCK KISS1 RXFP4 MRGPRD RXFP1 RXFP2 RXFP3 AGTR2 FPR1 FPR3 C3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 PNOC C5AR2 C5AR1 C5 GPR37 SAA1 C3AR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 APLN CCR5 GPR37L1 KEL NLN PENK PPY GAL OPRD1 NPB CXCR4 NPW PRLH MAS1 XK MC2R PF4 NPY2R NPY1R APLNR PYY HEBP1 POMC APP GPER1 NPY5R SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 ACKR1 AVPR2 CCL3 MCHR1 NPY SSTR3 OPRM1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses CGAS DTX4 MRE11 TRIM21 XRCC6 XRCC5 STING1 PRKDC STAT6 TBK1 TREX1 IRF3 NLRC3 IFI16 NLRP4 DDX41 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins NUP37 HDAC4 UBE2I NUP107 NUP188 PIAS1 SUMO1 SUMO3 SUMO2 NUP210 NUP93 H4C9 NUP205 POM121 BMI1 NUP214 CBX5 AAAS RING1 NUP160 POM121C NUP85 TPR NUP88 SATB1 RNF2 NUP155 NUP153 CBX8 CHD3 PHC2 PHC1 CBX4 CBX2 NUP62 PHC3 NDC1 SEC13 NUP133 NUP50 NUP54 PCGF2 HDAC2 NUP42 HDAC1 SUZ12 L3MBTL2 NUP43 RAE1 RANBP2 NUP35 SATB2 ZBED1 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome NLRP3 NFKB1 APP MEFV NFKB2 PANX1 P2RX7 PYCARD PSTPIP1 CASP1 HMOX1 TXNIP HSP90AB1 TXN SUGT1 RELA MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A GALNS TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 NCOA1 HNRNPU PRDM16 UCP1 RXRA PPARGC1A PPARG PPARGC1B PPARA HDAC2 SMAD1 SMAD4 MBD3 HDAC1 MTA1 RBBP4 CIDEA ZNF423 EBF2 GATAD2B GATAD2A RBBP7 CHD4 COX7A1 MTA2 CHD3 MTA3 ELOVL3 BMP7 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex ERCC3 NELFB NELFCD NELFA ERCC2 NELFE NCBP1 NCBP2 GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E GTF2H5 POLR2F POLR2H SUPT5H CCNH POLR2K POLR2L SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression CD28 VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction LRP2 RDH10 RDH16 LRP10 LRP12 SLC24A1 LRP8 AWAT2 GUCA1B GUCA1A GUCA1C GRK1 OPN1SW RDH11 GRK7 SDC1 PDE6B PDE6A OPN1MW PDE6G LPL RDH5 MYO7A HSPG2 PPEF1 PRKCA RPE65 PLB1 LRAT HSD17B1 CNGA1 RDH8 GNAT1 RBP4 RBP2 NMT1 RBP1 NMT2 RDH12 GPC1 CALM1 GPC3 GPC2 RBP3 SAG GPC5 RETSAT GPC4 FNTA FNTB APOA2 GPC6 APOA1 APOA4 GUCY2D HSD17B6 RLBP1 GUCY2F AGRN CYP4V2 RCVRN TTR BCO2 GPIHBP1 PNLIP BCO1 METAP1 METAP2 APOB OPN1LW CNGB1 APOC3 SDR9C7 RHO APOC2 PRKCQ AKR1C1 AKR1B10 GNB1 APOM AKR1C3 SDC4 APOE LRP1 SDC2 AKR1C4 CAMKMT SDC3 GNGT1 RGS9BP STRA6 DHRS3 ABCA4 CLPS LDLR DHRS9 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle CAPZB MTMR1 PIK3R2 SENP1 RAB7A PIK3R1 FARP1 CAV1 SRGAP2 LMNB1 BAIAP2L2 BAIAP2L1 FAM169A TMPO VANGL1 ADD3 ACTN1 DEPDC1B TOR1AIP1 ARHGAP12 MCAM SNAP23 SLC4A7 ARHGAP1 STEAP3 MYO9B ARHGAP32 DIAPH1 POTEE DIAPH2 ESYT1 AKAP12 DIAPH3 SOWAHC VAMP3 ARHGAP39 ARHGAP5 SYDE1 RHOF ACTB ARHGAP21 BASP1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation NCOA1 HNRNPU PRDM16 UCP1 RXRA PPARGC1A PPARG PPARGC1B PPARA HDAC2 SMAD1 SMAD4 MBD3 HDAC1 MTA1 RBBP4 CIDEA ZNF423 EBF2 GATAD2B GATAD2A RBBP7 CHD4 COX7A1 MTA2 CHD3 MTA3 ELOVL3 BMP7 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases HSP90AB1 FOXM1 MYBL2 WEE1 HMMR HJURP YWHAE CEP57 CETN2 MIS18BP1 CEP164 CCP110 PPP2R2A PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA CEP290 NINL YWHAG RAB8A SKP1 FZR1 CDK5RAP2 OFD1 HSP90AA1 BORA CEP135 PPP1R12A FBXW11 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 SGO1 HAUS5 CSNK1E TUBG1 GTSE1 DYNLL1 FKBPL CKAP5 TUBA4A CENPF HAUS2 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 UBA52 AJUBA OPTN PAFAH1B1 SDCCAG8 DYNC1I2 CPAP DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 PSMD12 CCNB1 PSMD11 UBB TUBG2 MZT2B HAUS8 PSMD14 PRKAR2B MZT2A PSMD13 NME7 HAUS7 TUBGCP2 UBC CEP70 MZT1 CEP72 TUBGCP5 FBXL18 CEP192 TUBGCP6 PSMA7 TUBGCP3 PCNT TUBGCP4 PSMB6 RPS27A PSMD8 CEP76 CLASP1 CEP78 PSMB7 OBI1 PLK4 PSMB4 PSMD6 LCMT1 DYNC1H1 PPME1 ODF2 PSMB5 PSMD7 CDK11A CEP152 TICRR PSMB2 NDE1 CDK11B PLK1 PSMB3 PSMD2 TUBB4B PSMD3 TUBB4A PSMB1 NEDD1 PSMD1 ALMS1 CDK1 CEP41 CEP43 ADRM1 EP300 PSMA5 SEM1 PSMA6 PHLDA1 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 CDC25B PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PPP2R3B PKMYT1 XPO1 TP53 CDK7 TPX2 MNAT1 CDKN1A E2F1 E2F3 PPP2CA PPP2CB PPP2R1B RBX1 LIN54 LIN37 LIN9 LIN52 FBXL7 CDK2 CCNA2 CCNA1 RBBP4 CDC25C CCNH PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway PLA2G4A MAPK1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade CALM1 GUCA1B SAG GUCA1A GUCA1C FNTA GRK1 FNTB GRK7 GUCY2D PDE6B PDE6A GUCY2F PDE6G RCVRN METAP1 METAP2 PPEF1 CNGB1 PRKCA RHO PRKCQ GNB1 CNGA1 CAMKMT GNAT1 GNGT1 RGS9BP NMT1 NMT2 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions SLC7A6 SLC7A7 SLC7A5 SLC7A8 SLC7A9 CAV1 SLC16A1 ITGA3 MAG PPIL2 L1CAM MMP1 BSG ATP1B3 ATP1B2 SLC3A2 ATP1B1 ITGB1 SLC16A8 SLC16A3 ITGA6 SPN PPIA SLC7A11 SLC7A10 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX15 ALAS2 ALAS1 ALB ALAD FECH UROD COX10 UROS ABCG2 PPOX CPOX HMBS HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells PIK3R2 PIK3CB FYN PANX1 ADM CAPNS1 CTNNB1 CAPNS2 PIK3CA GNG3 CAPN2 CDH5 GNG2 GNG5 PRR5 GNG4 PDPK1 CALCRL GNG7 GNA11 GNG8 MLST8 AKT1 MAPKAP1 NOS3 PECAM1 PRKACA MTOR TLN1 CALM1 VCL PRKACG TRPV4 PRKACB ADCY9 PRKAR1B PRKAR1A RICTOR ADCY4 P2RY2 MMP14 ADCY3 PIK3CD ADCY2 ADCY1 FLT4 ADCY8 KDR ADCY7 PKN2 ADCY6 ADCY5 PRKAR2A PIEZO1 GNG10 PRKAR2B GNG12 GNAS GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 RAMP2 GNB5 GNGT1 GNGT2 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation OGDH GCSH DLD GNMT GOT2 PRODH2 AGXT2 AMT AGXT GLDC DLST GRHPR DDO KGD4 ALDH4A1 HAO1 HOGA1 DAO PXMP2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis LRP2 CD3G CTTN IL7R PIP5K1C ARPC1A EGF EGFR NEDD8 TRIP10 OCRL LDLRAP1 EPGN SCARB2 ARRB1 AGFG1 M6PR KIAA0319 VAMP3 TOR1A SYNJ2 TOR1B SYNJ1 GPS1 SYT9 SYT8 RAB5A SNAP91 AAK1 STON1 STON2 SH3GL3 PIK3C2A SLC2A8 SLC18A3 VAMP8 SH3GL1 SGIP1 GAK EPN2 DNAJC6 VAMP4 FCHO1 HGS RAB5C FCHO2 UBQLN1 TGOLN2 REPS2 UBQLN2 REPS1 NECAP2 SYT11 SNX9 STAM2 HIP1R UBA52 IGF2R WASL NECAP1 VAMP7 CD4 UBB UBC AGTR1 CD3D RPS27A GRK3 COPS7B COPS7A WNT5A SYT2 DVL2 COPS3 COPS6 FZD4 COPS5 VAMP2 ARPC4 CLTB ARPC5 COPS8 ARRB2 TACR1 COPS4 ARPC2 ARPC3 COPS2 SH3KBP1 DAB2 CLTCL1 AVP GAPVD1 TF ACTR3 RAB5B ACTR2 AREG AVPR2 CLTC EPS15 CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 HSPA8 BIN1 GRK2 SNX18 AMPH PACSIN2 HIP1 PACSIN3 PACSIN1 EREG BTC CFTR HBEGF PICALM CHRM2 ARFGAP1 CBL ARF6 ADRB2 APOB STAM ITSN2 TGFA TFRC EPS15L1 EPN1 ITSN1 FNBP1L SYT1 FNBP1 LDLR TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 OPRK1 GAD1 GAD2 MEF2C PVALB TBL1XR1 GPRIN1 GRIA2 TNRC6C MOV10 AGO3 AGO4 RBFOX1 AGO1 AGO2 PPARG TNRC6A MOBP TNRC6B MET PTEN GRIN2A FKBP5 GRIN2B AURKB CRH DGCR8 PRKACA BDNF GAMT TRPC3 SOX2 SIN3A CALM1 LBR SGK1 SST SLC2A3 NCOR2 HTT PTPN4 NCOR1 CAMK4 HIPK2 GPS2 HDAC2 PTPN1 TBL1X HDAC3 HDAC1 DLL1 FOXG1 OPRM1 CAMK2B CAMK2D CAMK2A IRAK1 CAMK2G ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAB2 PRKAA2 MAPK12 PRKAB1 PRKAG1 PRKAG2 PPARGC1A MAPK14 MAPK11 PRKAG3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System RPS6KA3 RPS6KA2 RPS6KA1 BCHE GJC1 MYO6 GJA10 GJD2 DBNL GRIN2A KCNQ2 KCNQ3 GRIN2B GNAI1 GNAI2 PRKX TOMT PLCB3 PRKACA SYT9 PLCB1 PLCB2 SLC18A3 KCNS3 RTN3 SHANK3 IL1RAPL1 PTPRS SLC6A3 PRKAR2B SLC1A1 CACNA1A CACNB2 SLC1A2 CACNB3 SLC1A3 CACNA1E SLC1A6 SLC1A7 SLC38A2 SLC38A1 KCNK9 KCNK3 LIN7B SLC6A4 VAMP2 GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA2 NRXN1 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 PRKAB1 SLC5A7 RASGRF2 DNAJC5 GLS2 KCNQ4 KCNQ1 PRKCA KCNJ11 PTPRD PPFIBP2 EPB41L3 SLITRK2 SLITRK1 IL1RAPL2 KCNAB2 SLITRK4 SLITRK6 LRRC4B ABCC9 KCNN2 SRC KCNA5 PTPRF KCNH2 GLS HSPA8 SLITRK3 PRKAG1 SLITRK5 KCNN1 PRKAG3 KCNN3 KCNN4 HCN4 GLUL HCN3 HCN2 HCN1 PRKACG SLC6A12 SLC6A11 PRKACB GRM1 GRM5 SLC32A1 SLC6A13 ABAT SLC6A1 ALDH5A1 MAPK1 ADCY9 PRKAR1B SYT10 MAPK3 PRKAR1A MAOA ADCY4 ADCY3 ADCY2 KPNA2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A KCNK6 KCNK7 KCNK1 UNC13B PRKAB2 PANX2 RAB3A SYT1 SYN3 GIT1 SYN2 CACNA2D2 CPLX1 SYN1 RIMS1 PPFIA1 HRAS PPFIA4 SLC18A2 PPFIA3 PPFIA2 GNAT3 ARHGEF9 GAD1 GAD2 KCNMB1 KCNMA1 NRAS KCNMB2 KCNMB3 KCNMB4 GNAI3 ARL6IP5 NAAA MDM2 LRFN3 LRFN2 PDPK1 LRFN4 AKAP5 LRFN1 KCNC2 PRKAG2 CAMK1 CAMKK1 CAMKK2 PRKAA1 KCNK10 KCNK13 KCNJ14 KCNK16 KCNK17 STX1A KCNK18 KCNK2 KCNK4 SLC22A2 SLC22A1 PPFIBP1 CALM1 KCND1 SLC17A7 KCND2 CHRNA1 CHRNB2 KCND3 CHRNB4 CHRNA3 CHRNA2 CHRNB3 CHRNA5 CHRNA4 CHRNA6 ALDH2 RPS6KA6 KCNB1 ACTN2 CASK GABRG3 GABRG2 ABCC8 CHRNA7 KCNG2 CHRNA9 GNG10 LIN7A LIN7C GRIN2C GRIN2D GRIN3B GNG12 GNAL GNG11 DLG2 GNG13 GRIN3A DLG3 NBEA GNB2 GABRB3 GABRB2 GNB1 GABRB1 GRIK5 DLG4 GNB4 RASGRF1 GRIK3 GNB3 GRIK4 GRIK1 GNB5 GRIK2 NRGN FLOT1 PRKCG GABRR3 GNGT1 GABRR2 GABRR1 NPTN GNGT2 NEFL SYT2 HTR3E KCNJ1 HTR3C KCNJ8 HTR3D HTR3A HTR3B LRRC7 PPM1E NCALD SIPA1L1 PPM1F GLRA1 LRRTM3 CHRND LRRTM4 GLRA2 LRRTM1 GLRA3 LRRTM2 HOMER3 PANX1 CHRNG DLGAP1 CHRNE DLGAP3 KCNJ2 DLGAP2 KCNJ3 DLGAP4 GABRA2 STXBP1 GABRQ SHANK2 SHANK1 KCNJ4 GABRA1 NLGN3 GNG3 GABBR2 NLGN1 NLGN2 KCNJ5 EPB41 GNG2 KCNJ6 GABBR1 NRXN3 GNG5 NRXN2 GNG4 KCNJ10 BEGAIN GABRA6 GNG7 EPB41L5 GABRA5 EPB41L2 GNG8 KCNJ12 PDLIM5 KCNJ9 GABRA4 NLGN4Y KIF17 GABRA3 NLGN4X HOMER1 KCNJ15 HOMER2 KCNJ16 GRIN1 SYT7 SYT12 GLRB APBA1 APBA3 APBA2 SNAP25 KCNG1 KCNG3 KCNG4 KCNC1 KCNA1 KCNC3 AP2A1 KCNA2 KCNC4 KCNA3 KCNA4 KCNA6 KCNA7 KCNV1 KCNV2 KCNH1 KCNF1 CACNG8 KCNH3 KCNH4 CACNB1 CACNG2 KCNH5 CACNB4 CACNG3 CACNA2D1 KCNH6 CACNG4 CACNA2D3 KCNH7 KCNB2 CACNA1B KCNH8 KCNAB1 KCNAB3 KCNS1 KCNS2 FLOT2 KCNQ5 KCNA10 CHAT PRKAA2 RAC1 NRG1 TSPOAP1 SHARPIN COMT CAMK4 NTRK3 ACHE CAMK2B CAMK2D CAMK2A CAMK2G PRKCB TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse HLA-DQB2 CD3G HLA-DRB1 HLA-DQB1 ZAP70 PTPN22 CD4 TRAC LCK CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 TRAV19 HLA-DRB5 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 TDG OGG1 MBD4 SMUG1 APEX1 NTHL1 MPG RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine H2AC14 H2BC21 H2BC12L H2AC8 H2AC6 H2AC7 ACD TINF2 TERF1 H2BC17 TERF2 H2BC12 POT1 H2BC13 TERF2IP H2BC14 H2BC15 H2AJ H2BC11 H4C9 OGG1 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2AC20 MPG H2BC1 H2AX H2AC19 H2BC26 NEIL3 H2AB1 H2AZ2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR PSENEN ADAM17 PSEN2 APH1A APH1B NFKB1 PSEN1 RELA NGFR NCSTN TRAF6 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination RSPO2 RSPO1 RSPO4 FZD5 UBB FZD4 LGR6 LGR5 FZD6 LGR4 FZD8 UBC ZNRF3 RPS27A RNF43 UBA52 WNT3A USP8 LRP5 LRP6 RSPO3 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC12A5 SLC12A7 SLC4A1 SLC4A4 SLC26A7 SLC26A9 SLC26A6 SLC4A8 AHCYL2 SLC5A5 SLC4A9 SLC4A10 SLC4A2 SLC26A11 SLC4A3 SLC4A5 SLC34A3 SLC4A7 SLC34A2 SLC20A2 SLC34A1 SLC12A3 SLC12A1 SLC26A2 SLC26A1 SLC26A4 SLC17A1 SLC12A6 SLC26A3 SLC13A1 SLC13A4 SLC20A1 SLC5A8 SLC12A2 SLC12A4 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors CYP26A1 ELK1 PIK3R2 SCD PIK3R1 MYLIP MYC PRKCZ PIK3CA TNRC6C MOV10 ALDH1A1 AGO3 AGO4 AGO1 GPAM AGO2 TNRC6A TNRC6B CCND1 CBFB RUNX1 NOS3 EGF EGFR GNAI1 GNAI2 CETP ARL4C EEPD1 ABCG1 HSP90AA1 PPP5C FOXA1 SMC3 FKBP4 RAD21 JUND GREB1 STAG1 STAG2 CXCL12 SMC1A TFF3 TFF1 KANK1 CXXC5 NRIP1 USF2 USF1 ZNF217 AKT2 FOSB AKT3 EBAG9 ABCA1 PDHA2 PDHA1 BCL2 CYP26B1 DLD CYP26C1 ATF2 KAT5 FOXO3 RDH5 XPO1 AKT1 PRMT1 ABCG8 ABCG5 FABP5 FABP6 CARM1 SRC SRF ANGPTL3 FOS CTSD ADH4 MMP7 MAPK1 MMP2 MMP3 MAPK3 MMP9 KPNA2 APOC1 APOC4 PTK2 TGFA DDX5 H2AC19 HRAS H2AC14 GNAT3 RXRG H2BC12L DLAT PDK4 NRAS CAV1 NR1H3 GNAI3 MED1 RDH11 CCNT1 HSP90AB1 PDPK1 GTF2F1 GTF2F2 STRN CREBBP CRABP2 H4C9 H2AC20 UHMK1 EPGN H2AX CDK9 PIK3R3 RARG PPID CALM1 H3-3B NCOA1 NCOA2 H3C8 NCOA3 RARB NCOR2 KAT2B PPARD H2AJ PDHB NR5A2 NCOR1 GTF2A1 GTF2A2 UGT1A3 PLIN1 GPS2 H3C15 TBL1X POLR2A POLR2B GNG10 POLR2C POLR2D H2BC9 H2BC8 GNG12 RXRB H2BC5 POLR2G GNG11 GNG13 H2BC3 POLR2I APOC2 H2BC1 KDM1B GNB2 POLR2J GNB1 AKR1C3 GNB4 GNB3 IGF1R GNB5 CRABP1 GNGT1 DHRS3 PDK3 DHRS4 GNGT2 H2AB1 ALDH1A3 SDR16C5 PDK2 DHRS9 PDK1 EP300 ALDH1A2 ZDHHC7 PDHX RDH10 RDH16 SPHK1 CAV2 RDH14 RDH13 ALDH8A1 H2AC8 H2AC6 H2AC7 NR1H2 TBL1XR1 ESR1 GNG3 RXRA GNG2 GNG5 GNG4 SP1 GNG7 RARA KDM3A GNG8 PGR KDM4A S1PR3 KDM4B ADH1C YY1 APOD AREG ADH1A FKBP5 ZDHHC21 AXIN1 JUN POU2F1 H2BC26 MYB H2BC21 CDKN1B PTGES3 KDM1A TBP EREG H2BC17 BTC CITED1 H2BC12 H2BC13 H2BC14 H2BC15 HBEGF H2BC11 GATA3 TLE3 KCTD6 HDAC3 HDAC1 ESR2 POLR2E POLR2F APOE FASN POLR2H PCK1 POLR2K POLR2L H2AZ2 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events OPRK1 CXCL6 CXCL9 CXCL8 CXCL1 CXCL13 CXCL3 CXCL2 CX3CL1 CXCL5 CXCL16 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CXCR5 CXCR6 CXCR1 CCR6 CCL5 CXCR3 CCL4 CXCR2 CCR2 CCL1 CCL19 CCL16 CCR10 CCL25 CCR1 CCL21 TAS2R7 CCL20 PPBP CXCL10 TAS2R8 KNG1 CXCL11 ACKR3 CCL28 GNAI1 CCL27 GNAI2 PPP2R1A HCAR2 HCAR3 HCAR1 PRKX PLCB3 PRKACA PLCB4 GRM4 TAS2R1 TAS2R3 PLCB1 TAS2R5 PLCB2 TAS2R4 CXCL12 AGT TAS1R2 TAS1R1 RGSL1 TAS1R3 OPN1LW PRKAR2B PDYN LPAR1 LPAR2 LPAR3 FPR2 ITPR1 ITPR2 GPR17 ITPR3 LPAR5 NMS NMU PSAP DRD3 ADRA2B DRD4 CX3CR1 ANXA1 ADRA2C ADORA3 ADRA2A MT-RNR2 ADORA1 PRKCD PRKCA PMCH RGS4 RGS5 RGS3 RGS1 CASR SRC GNAT1 MCHR2 PDE1C GRK2 NMUR2 NMUR1 PRKACG PRKACB BDKRB2 BDKRB1 SST MAPK1 ADCY9 PRKAR1B RGS18 RGS17 PRKAR1A RGS19 RGS13 RGS16 ADCY4 ADCY3 RGS21 ADCY2 KPNA2 ADCY1 ADCY8 ADCY7 CHRM2 ADCY6 CHRM4 ADCY5 PRKAR2A HRH4 HTR1E HTR1F GNAS HTR1D HTR1B HTR5A PDE1B RXFP4 PDE1A GNAT3 GNAZ RXFP3 AGTR2 GNAI3 FPR1 FPR3 C3 GALR3 OPN1SW GALR2 GALR1 NPBWR1 NPBWR2 OPN1MW GPR183 PNOC GPR18 C5AR1 C5 GPR37 GPR31 RGR AHCYL1 SAA1 CAMKK1 CAMKK2 P2RY12 C3AR1 P2RY13 P2RY14 GPR55 MTNR1A MTNR1B RLN3 INSL5 CALM1 P2RY4 APLN RRH OXER1 CCR5 GPR37L1 TAS2R19 TAS2R42 TAS2R45 PENK PPY PPP1R1B TAS2R60 PTGDR2 RGS9 PPP3CC RGS6 OXGR1 RGS7 GAL OPRD1 NPB PTGER3 CXCR4 NPW TAS2R20 GNG10 CCL4L2 PF4 NPY2R RGS8 GNG12 GNAL GNG11 GNG13 NPY1R PCP2 APLNR NBEA GNB2 GNAQ SUCNR1 GNB1 GNB4 GNB3 GNB5 OPN3 GNAT2 TAS2R10 PRKCG TAS2R13 OPN5 GNGT1 PPP1CA PYY TAS2R14 GPSM1 TAS2R16 GPSM2 GNGT2 TAS2R9 PPP3R1 GRM3 HEBP1 POMC GRM2 GRM7 GRM6 APP GPER1 GRM8 PDE4A GPSM3 PPP3CA PPP3CB NPY5R PDE4D PDE4C GNA14 TAS2R40 SSTR1 TAS2R41 GNG3 TAS2R43 GABBR2 SSTR2 GNA15 TAS2R46 SSTR4 SSTR5 GNG2 GABBR1 CORT GNG5 RGS14 GNG4 NPY4R GNG7 OPRL1 GNA11 GNG8 CNR2 CNR1 RGS20 TAS2R30 S1PR3 RGS22 TAS2R31 S1PR2 S1PR5 RGS11 TAS2R38 S1PR4 TAS2R39 RGS10 RGS12 CDK5 MCHR1 PPP2R5D PPP2CA PPP2CB TAS2R50 PPP2R1B NPY CAMK4 SSTR3 RHO PLA2G4A OPRM1 CAMK2B CAMK2D CAMK2A CAMK2G SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription RB1 ZCRB1 DDX5 VHL ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME ABCG2 NT5C2 PCK1 ADH1A SLC22A2 SLC22A3 MAPDA ABCB1 SLC22A1 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle ANAPC7 UBE2C CDKN1B UBE2E1 UBE2S CCND3 CDC16 CCND2 ANAPC4 ANAPC5 ANAPC1 ATRX ANAPC2 CDKN1C SKP2 E2F2 DAXX CDK6 CCND1 CCNE2 CCNE1 CDK4 CDK2 TFDP1 TFDP2 RB1 ANAPC15 CDKN1A ANAPC16 UBE2D1 E2F1 ANAPC10 E2F3 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT H2AC14 CUL3 H2BC12L CAV1 MYC PIP5K1B CREBBP LRP5 LRP6 H4C9 CSNK1G2 RUNX3 TNKS TNKS2 RNF146 SMARCA4 WNT8A WNT8B H2AC20 PPP2R1A H2AX USP34 BTRC ASH2L TRRAP RSPO3 H3-3B TCF7L2 H3C8 CSNK1E H2AJ UBA52 DKK1 DKK2 DKK4 AKT2 CHD8 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC LEF1 H2BC9 H2BC8 H2BC5 PSMA7 H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RUVBL1 PSMB2 SOX17 RNF43 WNT3 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 WNT5A H2AB1 ADRM1 EP300 WNT1 PSMA5 FZD1 SEM1 DVL1 PSMA6 DVL2 FZD2 PSMA3 MEN1 FZD5 PSMC5 DVL3 FZD4 PSMA4 H2AC8 PSMC6 FZD6 H2AC6 FZD8 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTBP1 CTNNB1 KAT5 RYK KMT2B KREMEN1 KREMEN2 XPO1 AKT1 YWHAZ SRY CSNK2A1 GSK3B CSNK2A2 AMER1 DPY30 AXIN1 PPP2R5B PPP2R5A TCF7L1 WNT3A PPP2R5D PPP2R5C CSNK2B H2BC26 PPP2CA PPP2CB SOX2 FRAT1 USP8 FRAT2 WNT9A APC PPP2R1B SFRP1 H2BC21 SFRP2 PPP2R5E WIF1 SOST WDR5 SOX9 RBX1 H2BC17 H2BC12 XIAP H2BC13 H2BC14 H2BC15 SOX3 H2BC11 SOX6 SOX7 SOX4 SOX13 CDC73 TLE4 HECW1 TLE3 TLE2 CCDC88C TLE1 RSPO2 RSPO1 AXIN2 PYGO1 RSPO4 CSNK1A1 PYGO2 TCF7 LGR6 TERT LGR5 SMURF2 HDAC1 LEO1 LGR4 CTNNBIP1 BCL9L KLHL12 BCL9 WNT4 CBY1 H3-4 DACT1 CXXC4 ZNRF3 RBBP5 H2AC19 H2AZ2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 CCNB2 CCNB1 PLK1 CDK1 NEK9 NEK6 NEK7 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 CDC25B PSMC3 PSMA1 PSMA2 PSMC4 MYC PSMC1 PSMC2 CKS1B SKP2 MAX CCND1 CABLES1 AKT1 WEE1 CDK7 RBL2 TFDP1 TFDP2 MNAT1 E2F4 CDKN1A E2F1 SKP1 FZR1 CDKN1B E2F5 LIN54 LIN37 LIN9 LIN52 UBA52 AKT2 AKT3 CCNE2 CCNE1 CUL1 PSMD12 PSMD11 UBB PTK6 CDK4 PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RBBP4 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 RB1 PSMB3 PSMD2 CCNH PSMD3 PSMB1 PSMD1 ADRM1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGLV1-44 IGKV3-15 IGKV3-11 LYN SYK PIK3R1 IGKV2D-40 IGHV3-11 IGHV3-13 FYN IGKV1D-16 DAPP1 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 PLCG2 IGKV3-20 IGHV4-34 BLK IGHV1-2 SH3KBP1 IGHV1-46 IGHV4-39 PTPN6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 CD19 IGLC2 IGKV3D-20 NCK1 IGLV3-19 IGKV2-30 AHCYL1 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 PIK3AP1 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 IGLC6 TRPC1 CALM1 CD79B CD79A BTK STIM1 IGHV3-23 IGLV PIK3CD IGLV2-8 SOS1 IGKV1-16 ORAI2 IGKV1-17 ORAI1 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 BLNK IGHV3-33 IGKV1D-39 IGKV1D-33 IGHM IGKV2D-28 IGKV4-1 IGHV7-81 CD22 ITPR1 ITPR2 IGHD IGKV2D-30 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 VAV1 IGLV2-14 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants APC PPP2R1B PPP2R5E CSNK1A1 CTNNB1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib SLC37A4 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO2B1 SLC16A2 SLCO2A1 SLCO1B1 SLCO1A2 SLCO1C1 SLCO4A1 SLCO1B3 AVP SLCO4C1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs ALOX15 ALOX12 ALOX5 PTGS2 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis CAPZB KIF13B HMG20B KIF1C KIF1B KIF1A JAK2 KIF25 KIF23 SLC16A1 KIF22 KIF6 RBSN KIF27 L1CAM RAD51B KIF9 RAD51C KIFC2 CLU AHSG KIF2A KIFC1 IRF1 IRF2 KIF2C KIF2B DOCK2 AKAP1 CDC42 MFN1 MFN2 LAMP2 SH2B3 SH2B2 SH2B1 CABLES1 CABLES2 CENPE MERTK WEE1 KIF26A CAPZA1 NOS3 KIF26B CAPZA2 PPBP STXBP2 PRTN3 ORM1 ORM2 TRPC7 CAP1 TRPC6 TRPC3 NOS2 VCL TNFRSF10B CFL1 APOOL TNFRSF10A SERPINB2 ANXA2 MIF IGHV3-23 SPARC IGLV SOD1 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 CEACAM6 V2-17 V3-2 CEACAM8 IGHV3-33 V2-15 IGKV1D-39 IGF2 V2-19 IGKV1D-33 SLC7A11 JAM2 IGKV2D-28 QSOX1 JAM3 IGKV4-1 IGHV7-81 SLC7A10 PRKCQ CD63 V1-11 IGKV2D-30 CD58 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 LAT SLC7A6 IGLV1-44 SLC7A7 IGKV3-15 SLC7A8 IGKV3-11 LYN SLC7A9 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 ITGAX IGKV1D-16 A1BG IGLV7-43 IGKV1D-12 ITGA3 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 SERPINA3 IGHV1-2 TSPAN7 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 PICK1 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 AKT1 IGLV3-19 IGKV2-30 IGHV2-70 PRKCD IGHV2-5 PRKCA IGLV3-1 IGHV3-48 YWHAZ IGLV3-25 IGLV3-27 PRKCE IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 ITGAL IGKV5-2 IGKV1-5 IGLC6 STXBP3 STX4 ITGA4 PAFAH2 MAPK14 CEACAM3 ITGA5 PRKACG PRKACB RAP1A MAPK1 PRKAR1B MAPK3 PRKAR1A SOS1 PIK3CG KIF3A PRKAR2A APOB GNAS CD84 ITGB2 YES1 GUCY1A2 GUCY1A1 HRAS GUCY1B2 GUCY1B1 PDE1B BRPF3 PDE1A PDE2A IRAG1 PDE11A TNFRSF10D PDE10A KCNMB1 VEGFA KCNMA1 NRAS LRP8 KCNMB2 KCNMB3 KCNMB4 CFD NOS1 PDE9A CEACAM5 CD109 SERPINE1 CEACAM1 P2RX4 SMPD1 PIK3R3 PIK3R6 PIK3R5 SLC7A5 RAPGEF3 RAPGEF4 ACTN2 PF4 ITGA2 ITGA10 ITGA2B MMRN1 PPIL2 HSPA5 PPIA TP53 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E RAB27B ITGB1 GP1BA GATA3 ADAMTS13 VWF PLA2G4A THBS1 MGLL PRKCB PIK3R2 PIK3CB PIK3R1 TGFB2 IGHA1 TGFB3 IGHA2 JCHAIN PRKCZ PDPN MPIG6B PLCG2 GP6 SERPINE2 PIK3CA PROS1 PTPN6 ITGB3 SERPINA10 F13A1 SERPINA5 THBD PF4V1 CD177 FGB ITGAV FGA GP1BB TGFB1 FGG F2R F2 F3 F5 F7 PROCR F8 PECAM1 EGF F9 SERPING1 PLCG1 SERPINC1 PROZ KNG1 F10 SERPIND1 F12 F11 GP5 GNAI1 GP9 ITPK1 GNAI2 PROC F13B PPP2R1A PRKACA FLNA TUBA4A P2RX6 P2RX5 STIM1 P2RX3 P2RX2 P2RX1 ORAI2 ORAI1 ANGPT4 ANGPT2 ABCC4 ANGPT1 SHC1 DOK2 GRB14 TEK PRKAR2B PRKCH ITPR1 ITPR2 SERPINF2 PLAUR ITPR3 SDC4 PLAT SERPINB8 SERPINB6 SDC2 PLAU HRG SDC3 S100A10 PSAP MPL THPO ADRA2B CYB5R1 VPREB3 VPREB1 ALB PSG1 PSG3 PSG2 CD74 PSG9 FCAMR MAG PSG8 PSG5 PSG4 PSG7 SDC1 PSG6 GYPA BSG GYPC ATP1B3 GYPB ACTN4 CD99L2 IFNA5 ATP1B2 GLG1 ATP1B1 SLC3A2 IFNA4 CD48 IFNA7 SELPLG IGLL1 ADRA2C IFNA6 SLC16A8 ADRA2A IFNA1 SLC16A3 IFNA2 PSG11 IFNA8 F2RL2 SELE F2RL3 RAF1 SELP HSPG2 DGKG ESAM DGKE SPN DGKD CD2 CD244 DGKB DGKA ABHD12 ANO6 LCK DGKZ ANO5 SRC A2M DGKQ DGKK DGKI DGKH ABHD6 CSK GPC1 DAGLA GPC3 PCDH7 GPC2 GPC5 TIMP1 GPC4 GPC6 IFNB1 TTN MMP1 DAGLB ACTN1 AGRN PFN1 P2RY1 CXADR GRB7 ITGA6 IFNA14 CD44 IFNA16 INPP5D IFNA17 PLG PTK2 RAC2 KLKB1 IFNA10 AAMP F11R VAV3 RHOG VAV1 GNAT3 VAV2 RHOB IFNA21 SYK FGR CAV1 GNAI3 FYN JAML ALDOA PDGFB PDPK1 CD99 SELL TREM1 P2RY12 PTPN11 ARRB1 VPS45 TBXA2R GNA12 SLC8A3 RAB5A ATP2B4 ATP2A3 ATP2A2 ATP2B3 ATP2A1 CLEC1B ATP2B2 ATP2B1 FN1 SRI CD36 CALM1 SLC8A1 PRKG2 H3-3B SLC8A2 H3C8 LCP2 APOA1 ISLR HABP4 CHID1 GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 ENDOD1 APOH VTI1B MANF CALU MAGED2 FERMT3 ECM1 OLA1 CTSW SERPINA4 H3C15 TMSB4X TIMP3 ANXA5 GNG10 TOR4A SPP2 LEFTY2 IGF1 LY6G6F GNG12 VEGFB GNG11 VEGFC GNG13 IGHM CD47 VEGFD LHFPL2 PCYOX1L GNB2 POTEKP GNAQ FAM3C GNB1 SIRPG APLP2 TMX3 SELENOP GNB4 SCG3 GNB3 RARRES2 CYRIB GNB5 SCCPDH SIRPA LGALS3BP PRKCG WDR1 GNGT1 PLEK PHACTR2 SRGN ITIH4 GNGT2 ITIH3 CLEC3B CDC37L1 CD9 APP PDE5A ARRB2 P2RX7 PTGIR ITGAM GNA14 GNA13 GNG3 GNA15 GNG2 GNG5 APBB1IP GNG4 GAS6 GNG7 EPCAM GNA11 GNG8 ABL1 RAP1B ITGA1 HGF TF DOCK7 CBX5 MAFK CDK5 OLR1 TLN1 SIN3A MYB KIF28P KDM1A JMJD1C RAC1 DOCK10 DOCK11 KIF5C KIF5B KIF5A KIF21A RHOA KIF21B KIFAP3 HBE1 KIF16B KIF20A KIF20B ZFPM2 ZFPM1 GATA6 DOCK1 GATA5 CRK AK3 GATA4 KLC1 GATA2 GATA1 PHF21A KLC4 KLC3 KLC2 KIF3B HDAC2 PTPN1 RACGAP1 MICAL1 KIF3C NFE2 CDK2 CARMIL1 HDAC1 BCAR1 HBG2 HBG1 EHD1 EHD2 KIF18A EHD3 FCER1G KIF18B SERPINA1 KIF4B KIF4A MAFG MAFF RCOR1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 HBB KIF12 KIF11 HBD KIF15 AKAP10 KIF19 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex APC PPP2R1B PPP2R5E CSNK1A1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels HCN4 HCN3 HCN2 HCN1 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress CAPZB NOX4 RPS6KA3 CXCL8 RPS6KA2 RPS6KA1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 CUL7 ATP7A CCL2 CUL2 DDIT3 CAPZA1 CAPZA2 SEC31A HBA2 EIF2S3 EIF2S2 EIF2S1 ATP6V1H LMNB1 LY96 DEFA5 DCTN1 TLR4 UBE2D2 SOD2 SOD1 ATOX1 FBXL17 BACH1 PSMD12 PSMD11 CHD6 NOTCH1 PSMD14 PSMD13 RPLP1 PSMA7 SLC7A11 RPLP0 PSMB6 PSMD8 UBE2D3 PSMB7 PSMB4 PSMD6 RPLP2 PSMB5 HSPA1B PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 BAG4 PSMD1 BAG2 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 SIRT3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 ATF2 EXTL2 KAT5 FOXO3 RRAGA EXTL3 RRAGC RRAGB RRAGD XPO1 KHSRP AKT1 FABP1 NUP214 PRDX2 DIS3 PRKCD PRDX1 MAPKAPK2 DCP2 RPL22L1 PARN EXOSC7 EXOSC6 ATM EXOSC5 EXOSC4 EXOSC9 ATR EXOSC8 EXOSC3 CDKN1A EXOSC2 EXOSC1 HSPA8 MAPK14 BRCA1 MAPK11 HSPA1A RPTOR FOS RBX1 MAPK1 MAPK3 COX4I1 RPA1 COX4I2 RPA2 ME1 RPA3 LAMTOR2 P4HB LAMTOR1 APOB LAMTOR4 ARNT LAMTOR3 LAMTOR5 CCNA2 MRE11 CCNA1 SESN2 MT-CO1 NBN CAPZA3 ACTR10 ZBTB17 MAPKAPK5 SLC38A9 DCTN6 DCTN5 MAP2K6 DCTN4 CUL3 MT-CO2 MT-CO3 VEGFA CLOCK ACD RHEB TINF2 TERF1 NUP107 TERF2 POT1 MDM2 NUP188 HSPB8 TERF2IP HIKESHI MDM4 CCAR2 DNAJC2 SULT1A3 DNAJC7 CRYAB RPS19BP1 NUP210 HSPA4L HSPA14 HSPA13 DNAJB1 NUP93 HSPH1 SQSTM1 RPL23A BAG5 DNAJB6 BAG3 MLST8 CAT BAG1 NUP205 HSPA1L POM121 HSPA4 ST13 HSP90B1 HSPA7 HSPA6 AAAS HSPA12A HSPA12B NUP160 POM121C NUP85 TPR NUP88 IL1A NUP155 HMGA1 NUP153 MTOR RAD50 NUP62 ELOB ELOC ATF3 NDC1 SEC13 NUP133 RPL27A HIRA NUP50 NUP54 GSTP1 CDKN2B NUP42 CREB3 NUP43 DCSTAMP CREB3L3 CREB3L4 CREB3L1 RAE1 CREB3L2 RANBP2 CREBRF IGFBP1 NUP35 NRF1 NUP37 NPAS2 G6PD EP400 RORA NR3C1 ESR1 NR3C2 AR KDM6B RXRA SP1 HSPA5 EIF2AK3 PGR PPARA CDK6 TP53 GCLC ATF6 CYCS FKBP5 GCLM CHD9 CSNK2A1 CSNK2A2 AMER1 PPP2R5B CSNK2B BLVRB ATF5 SAMTOR BLVRA STOML2 NPRL2 PRKAA2 NPRL3 EIF2AK1 PHB2 EIF2AK4 H1-1 H1-0 H1-3 H1-2 YME1L1 H1-5 MBTPS1 H1-4 NOX5 CITED2 EXTL1 EGLN1 MBTPS2 EGLN3 RPL26L1 EGLN2 RPL4 CASTOR1 RPL5 WTIP RPL30 CASTOR2 RPL3 ERO1A RPL32 SESN1 MAP3K5 RPL31 MUL1 RPL34 ARFGAP1 IMPACT RPL8 HM13 SH3BP4 RPL6 NUDT2 RPL7 TALDO1 RPL36 RPL35 PREB TRIB3 KDELR3 RPL38 OMA1 PLA2G4B RPL37 DELE1 RPL39 FKBP14 HERPUD1 MYDGF ATF4 MINK1 CAMK2B HSBP1 DEPDC5 HSF1 CAMK2D YIF1A RPL21 NPLOC4 HDGF CAMK2A ETS2 RPL23 UFD1 ERN1 RPL22 HTRA2 HSPD1 GCN1 CAMK2G HMGA2 CABIN1 GOSR2 DYNC1LI1 CRTC1 KICS2 DYNC1LI2 RPL24 SOD3 CCS TSPYL2 RPL27 DDX11 RPL26 ASF1A RPL29 SEH1L RPL28 HIF1A PRDX3 SSR1 WDR59 MYC PRDX6 HIF3A MIOS WDR24 UBN1 CDKN2D CDKN2C ID1 COX7B EPO TNRC6C MOV10 AGO3 ERF RPL41 AGO4 TNIK AGO1 COX7C IGFBP7 RPL3L WFS1 TPP1 TNRC6A SRXN1 TNRC6B HIF1AN GPX3 ADD1 GPX6 COX8A GPX5 GPX8 COX8C GPX7 WIPI1 CTDSP2 EGF CEBPG PPP1R15A DNAJB9 FNIP1 YWHAE FNIP2 DYNLL2 TXNRD2 DNAJA1 COX5B DNAJA4 COX5A LONP1 ACTR1A LIMD1 SERP1 UBXN7 ITFG2 KPTN CEBPB MAP4K4 ANAPC15 BTRC TATDN2 ANAPC16 SZT2 UBE2D1 PDIA6 ANAPC10 PDIA5 RELA COX6C DPP3 ANAPC11 KLHDC3 FZR1 SKP1 SRPRA CDC23 SRPRB CDC26 FLCN RPL10 HSP90AA1 CDC27 ATF6B RPL12 VENTX ABCF2 RPL11 ANAPC7 RPL14 UBE2C CDKN2A RPL13 UBE2E1 RPL15 NFKB1 RPL18 COX6A1 HSPA2 IL6 RPL17 COX6A2 UBE2S RPL19 CDC16 TXN2 ANAPC4 ANAPC5 ANAPC1 DYNLL1 FKBP4 ANAPC2 RPS15 RPS14 UBA52 RPS17 AJUBA RPS16 COX6B2 RPS19 NRIP1 COX6B1 RPS18 DYNC1I2 AKT2 DCTN2 AKT3 DCTN3 CUL1 RPS11 SHC1 RPS10 RPS13 UBB NCF1 RPS12 NCF2 UBC NCF4 HIGD1A DNAJC3 HIGD1C RPS27A DYNC1H1 RPS4Y2 PALB2 RPS4Y1 STIP1 STAT3 BCL2 ASNS BCL2L1 ALB RPS26 CA9 ATP6V1E1 RPS25 ATP6V1E2 RPS28 ATP6V1G1 RPS27 ATP6V0E1 RPS29 RPL7A ATP6V1G2 RPS20 RPS21 RPS24 GPX2 RPS23 GPX1 GRB10 RPL37A ATP6V0D1 MAP1LC3B TGS1 ATP6V0D2 ATP6V1A RPL36A TXNRD1 RPL35A ATP6V1D ATP6V1C1 CARM1 ATP6V1F ATP6V1C2 SLC46A1 RPS27L RPS15A CHAC1 RPS3 TCIRG1 RPS2 ATP6V0B COX7A2L IFNB1 ATP6V1B2 HMOX1 ATP6V0C HMOX2 FAU ATP6V1B1 NR1D1 RPS9 RPS7 RPS8 RPS5 RPS6 ATP6V0E2 ATP6V1G3 RPSA RPL39L TKT RB1 VCP EHMT2 H2AC19 EHMT1 H2AC14 EDEM1 H2BC12L NLRP3 SYVN1 MED1 GSK3A RPL10L RPL10A HSP90AB1 RPS4X PGRMC2 RPS3A PPARGC1A CREBBP NQO1 DYNC1I1 PGD H4C9 BMAL1 AKT1S1 VHL H2AC20 EZH2 H2AX ABCG2 COX7A2 COX7A1 CRTC2 CRTC3 RAI1 HSPA9 CLEC1B MEF2D HYOU1 H3-3B NCOA1 NCOA2 H3C8 CYBB CYBA NCOA6 ACADVL APOA1 RPL13A SIRT1 NCOR2 H2AJ E2F2 NCOR1 ABCC3 CCNE2 ABCC1 CCNE1 H3C15 TBL1X SUZ12 H2BC9 H2BC8 CALR H2BC5 H2BC3 H2BC1 RPL18A DNAJB11 RPL36AL H2AB1 EP300 H2AC8 H2AC6 H2AC7 TBL1XR1 TXNIP TXN SKP2 HELZ2 HSPE1 BMI1 PDGFA ETS1 MAFK AREG NFE2L2 RING1 PRKCI EEF1A1 TFDP1 TFDP2 RNF2 HDAC6 DNAJA2 GSK3B CBX8 E2F1 PHC2 E2F3 CBX6 PHC1 JUN H2BC26 KEAP1 TLN1 CBX4 CBX2 SIN3A NFYA H2BC21 PHC3 NFYB MAPK7 CDKN1B NFYC PTGES3 TRIM21 GFPT1 EED LMNA GSTA3 H2BC17 GSTA1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 EPAS1 RPL9P9 COXFA4 STAP2 HDAC3 PTK6 CDK4 SMARCD3 CDK2 CXXC1 H3-4 RBBP4 AQP8 IDH1 MAFG RBBP7 HBB H2AZ2 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen ITGA1 LYN ADAMTS13 VWF ITGA2 ITGA10 FYN FCER1G GP6 GP5 GP9 ITGB1 GP1BA GP1BB DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection ACOT2 PQBP1 EIF4A3 PIK3R1 RNASEK SRRT KPNA7 KPNA4 CDC40 KPNA5 SRRM1 KPNA3 CLU SNRNP200 PROS1 SRSF2 SRSF3 SRSF4 CTNNBL1 SRSF5 HNRNPC SRSF6 SRSF7 SRSF9 UBA6 UBA5 PRCC UBR4 F2 SRSF1 U2AF1 MERTK KDELR1 U2AF1L4 U2AF2 CCAR1 DHX38 SRSF11 TIMD4 CD2BP2 ALYREF CTR9 RTF1 PCBP1 PCBP2 RNPS1 SYMPK RBM10 PAF1 RETREG1 DHX15 NEK2 DHX16 CD33 UBA3 UBA1 HSP90AA1 WBP11 HNRNPUL1 RTN3 RPL18 DDX3X DDX46 DDX42 LY96 RBM17 DYNLT1 BUD31 RBM22 DDX23 CSTF2T RIPK1 RRBP1 CD14 SMNDC1 UBA52 TLR4 TAOK1 U2SURP CLP1 SNRPD2 SNRPD1 HNRNPF HNRNPA2B1 TYRO3 SNRPD3 SNRPA1 UBB MRC1 SF3B4 UBC SF3B5 SF3B2 SF3B3 DNAJC3 SF3B6 RPS27A ATG14 SF3A3 SF3A1 SF3A2 XAB2 HSPA1B SDC4 RPN2 CLEC5A SDC2 NCL SDC3 VTN RPN1 PIK3R4 BAG2 CHERP EIF4G3 EIF4G2 EIF4E3 LYN PUF60 SNRPB2 AQR NFKBIA C4B_2 CTNNB1 SDC1 PRPF19 PCF11 DAXX MAGT1 MAPRE3 MAP1LC3B ELAVL1 PTBP1 HSPG2 XPO1 HAVCR1 IKBKE HNRNPH1 AXL MAPKAP1 HDLBP EFTUD2 HNRNPA1 PDIA3 HNRNPM CD300A XRN1 DPM1 DPM2 PABPC1 DPM3 DNAJC10 ELAVL2 CANX HSPA8 KPNB1 RPTOR HSPA1A EIF4G1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 STAT2 TJP1 STING1 RICTOR MMP9 AGRN TUSC3 KPNA2 P4HB FURIN SCAP RPSA TMEM258 SNRPG P4HA1 P4HA2 SNRPE P4HA3 SNRPF SNRPB VCP DDX5 H2AC19 H2AC14 OST4 MAVS OSTC STT3A STT3B HSP90AB1 KPNA1 NFKBIB MBL2 PRR5 GTF2F1 DDOST GTF2F2 DAD1 MLST8 H4C9 PIK3C3 TSG101 BECN1 H2AC20 CLINT1 MTOR NMT1 EIF4A2 EIF4A1 H2AC17 H2AC12 HYOU1 PRKG2 H3C8 ATL2 TAL1 NUDT21 PDCD6IP NCBP1 APOA1 LY6E NCBP2 H2AC25 FUS H2AC21 NACA ISY1 PABPN1 BCAS2 EIF4E C1S HNRNPA0 HNRNPA3 GPKOW CDC5L C4A CPSF7 H3C15 POLR2A SF3B1 POLR2B DHX9 POLR2C POLR2D CD209 H2BC9 H2BC8 CALR H2BC5 POLR2G SUGP1 H2BC3 POLR2I H2BC1 POLR2J PEX19 DNAJB11 PPIE NRBP1 H2AC1 SUN2 H2AC8 HNRNPU H2AC6 HNRNPR H2AC7 UBE2I BTF3 HNRNPL HNRNPK HNRNPD WDR33 SUMO1 H2BC18 GAS6 UBA7 HSPA5 PHF5A AUP1 IPO7 PAPOLA IFIH1 TXNL4A SNRPN VIM TRIM25 PLRG1 SKIC8 AP2A1 DNAJC8 AP2B1 FIP1L1 AP2A2 SEC11A SEC11C PPIL1 SNRNP40 AP2S1 DNAJA2 PPIL3 PPIL4 PPIL6 SRRM2 COG1 CRNKL1 H2BC26 CSTF3 CSTF2 SNW1 H2BC21 CSTF1 HNRNPH2 C1QA EMC4 SPCS3 H2BC17 SPCS2 SPCS1 H2BC12 CWC25 H2BC13 CWC27 H2BC14 CWC22 H2BC15 ATG7 PRPF6 H2BC11 PRPF8 RBMX CPSF4 CPSF1 CPSF3 CDC73 CPSF2 CWC15 CGAS EXOC1 LEO1 RBM5 GBF1 C4BPA C4BPB YBX1 CLDN1 CAMK2B POLR2E POLR2F CAMK2D FASN POLR2H NPLOC4 CAMK2A UFD1 POLR2K GRPEL1 POLR2L CAMK2G SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN BRAF NTRK1 RIT1 RIT2 NGF RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress PIK3R2 PIK3CB FYN PANX1 NFKBIA ADM CAPNS1 CTNNB1 CAPNS2 PIK3CA GNG3 ITGB3 CAPN2 CDH5 GNG2 GNG5 PRR5 CHUK GNG4 PDPK1 CALCRL GNG7 GNA11 GNG8 ITGAV ABL1 MLST8 IKBKE IKBKB AKT1 MAPKAP1 NOS3 IKBKG PECAM1 PPP2R2A PPP2R1A PRKACA MTOR RELA PPP2CA TLN1 ITGA5 CALM1 PPP2R1B VCL PRKACG NFKB1 TRPV4 PRKACB STAT1 ADCY9 PRKAR1B PRKAR1A RICTOR ANXA2 ITGB1 ADCY4 P2RY2 MMP14 ADCY3 PIK3CD ADCY2 ADCY1 FLT4 ADCY8 KDR ADCY7 PKN2 ADCY6 ADCY5 PRKAR2A PTPN1 PIEZO1 GNG10 PRKAR2B PTK2 GNG12 GNAS GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 RAMP2 GNB5 GNGT1 YAP1 GNGT2 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology CALM1 GPS2 TBL1X HDAC3 WDR5 HDAC1 TBL1XR1 RBBP5 KMT2D NCOR2 DPY30 ASH2L PRKACA NCOR1 CAMK4 SIN3A DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F8 F9 F10 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism LARS1 AIMP1 RPL24 AIMP2 RPL27 RPL26 RPL29 EPRS1 RPL28 GNMT IARS1 RPL10L RPL10A RPS4X RPL41 RARS1 RPS3A RPL3L RPL23A EEF1E1 AHCY RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL27A RPL13A RPS15 RPS14 RPS17 UBA52 RPS16 RPS19 RPS18 PSTK NNMT RPS11 RPS10 RPS13 MARS1 RPS12 RPLP1 RPLP0 CTH RPS27A RPS4Y2 EEFSEC RPLP2 RPL18A RPL36AL RPS4Y1 SEPHS2 SCLY MAT1A RPS26 RPS25 RPS28 KARS1 RPS27 RPS29 RPL7A RPS20 RPS21 RPS24 RPS23 INMT SARS1 CBS RPL37A RPL36A TXNRD1 RPL35A RPL22L1 HNMT DARS1 RPS27L RPS15A RPS3 RPS2 RPL26L1 FAU RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS5 RPL6 RPL7 RPS6 RPL36 RPSA RPL35 RPL39L RPL38 RPL37 RPL39 RPL21 SECISBP2 RPL23 SEPSECS RPL22 QARS1 PAPSS2 PAPSS1 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS NRAS NTRK2 BDNF SOS1 HRAS DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages LAMA5 LAMC3 LAMA3 EGF AREG LAMB3 TGFA LAMB1 LAMA2 LAMA4 PRL LAMB2 FGF7 FGF4 LAMA1 VTN FGF10 CSF1 LAMC2 LAMC1 IFNG FN1 FGF2 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli PIK3R2 PIK3CB FYN ADM PIK3CA ITGB3 CDH5 PRR5 CALCRL PDPK1 ITGAV MLST8 NOS3 PECAM1 CACNG7 PPP2R2A PPP2R1A PRKACA MTOR RELA CALM1 VCL NFKB1 TRPV4 GJA1 ANXA2 KDR PKN2 GNG10 PRKAR2B CACNB2 CACNB3 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 PANX1 NFKBIA P2RX7 CAPNS1 CTNNB1 CAPNS2 GNG3 CAPN2 GNG2 GNG5 CHUK GNG4 GNG7 GNA11 GNG8 ABL1 HSPG2 IKBKE AKT1 IKBKB MAPKAP1 IKBKG CACNB1 CACNA2D1 PPP2CA TLN1 ITGA5 PPP2R1B PRKACG PRKACB STAT1 ADCY9 PRKAR1B PRKAR1A RICTOR ITGB1 ADCY4 P2RY2 MMP14 ADCY3 PIK3CD ADCY2 ADCY1 FLT4 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A PTPN1 PIEZO1 PTK2 SPP1 GNAS RAMP2 CACNA1H YAP1 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching RFC5 RFC3 RFC4 RFC2 PRIM2 RFC1 PRIM1 POLA1 POLA2 PCNA POLD3 POLD1 POLD4 POLD2 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling TRADD TRAF1 RNF31 TRAF2 TNFAIP3 XIAP CASP8 OTUD7B SPATA2 SHARPIN RIPK1 USP4 FADD USP21 STUB1 MIB2 UBA52 UBE2D2 CHUK TNFRSF1A TBK1 CYLD OPTN RBCK1 OTUD1 BIRC2 BIRC3 IKBKE IKBKB TNF UBB IKBKG UBC RACK1 ULK1 MAPKAPK2 RPS27A UBE2D3 USP2 TAX1BP1 UBE2D1 SPPL2B SPPL2A CLIP3 OTULIN UBE2L3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex ERCC3 NELFB NELFCD NELFA ERCC2 NELFE NCBP1 NCBP2 GTF2F1 GTF2F2 CTDP1 POLR2A SUPT4H1 POLR2B POLR2C POLR2D CDK7 POLR2G POLR2I POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E GTF2H5 POLR2F POLR2H SUPT5H CCNH POLR2K POLR2L SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion SEMA3A PLXNA1 PLXNA2 PLXNA3 RAC1 FYN FES CFL1 PAK2 HSP90AB1 NRP1 PLXNA4 PAK1 LIMK1 PAK3 HSP90AA1 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly H2AC14 H2BC21 H2BC12L ADNP H3C8 CBX1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ H2BC11 H4C9 H3C15 CBX3 H2BC9 H2BC8 H2BC5 H2BC3 H2AC20 H2BC1 H2AX CHD4 H2AC19 H2BC26 H2AB1 ADNP2 H2AZ2 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 MEMO1 CDC37 ERBIN NRAS PIK3R1 FYN NRG1 PTPN12 NRG2 RHOA EREG BTC PIK3CA NRG3 NRG4 STUB1 UBA52 RNF41 HBEGF GRB7 SOS1 CUL5 AKT2 AKT3 AKT1 SHC1 GAB1 UBB PTK6 EGF PRKCD ERBB2 PRKCA PLCG1 EGFR UBC PRKCE DIAPH1 RPS27A SRC YES1 HRAS PTPN18 USP8 HSP90AA1 MATK COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATOX1 ATP7A THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH10 RDH16 RBP3 RPE65 SDR9C7 RHO RDH11 LRAT HSD17B6 RLBP1 HSD17B1 RDH8 CYP4V2 RBP4 TTR RDH5 STRA6 MYO7A RBP1 ABCA4 RDH12 DHRS9 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2R1B PRIM2 PRIM1 POLA1 POLA2 TFDP1 TFDP2 PPP2R3B PPP2R1A RB1 E2F1 PPP2CA PPP2CB CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes CCNB2 CSNK2A1 CCNB1 CSNK2A2 SMC4 SMC2 NCAPG NCAPH NCAPD2 CDK1 CSNK2B DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions VAV2 PIK3R2 KIR3DS1 SYK PIK3CB NRAS TREM2 PIK3R1 KLRK1 GRAP2 RAC1 FYN KLRC2 TYROBP KLRD1 LCP2 KIR2DS4 PLCG2 KIR2DS5 PIK3CA BTK CD300E SOS1 CD300LB B2M KIR2DS2 TREM1 PLCG1 HLA-B HLA-C LCK HLA-E NCR2 CLEC5A SIGLEC16 SIGLEC15 SIGLEC14 VAV3 HRAS SIRPB1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAF4 ERCC3 TAF3 TAF2 TAF1 ERCC2 TBP GTF2B GTF2A1 GTF2F1 GTF2A2 GTF2F2 TAF9 TAF1L POLR2A POLR2B POLR2C GTF2E1 POLR2D GTF2E2 CDK7 POLR2G POLR2I TAF9B POLR2J GTF2H1 GTF2H2 MNAT1 GTF2H3 GTF2H4 POLR2E TAF15 GTF2H5 POLR2F TAF12 TAF13 POLR2H TAF10 TAF11 CCNH TAF8 POLR2K POLR2L TAF4B TAF7 TAF6 TAF7L TAF5 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism PPARGC1A SIRT1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO1 SUMO3 SUMO2 UBA2 UBE2I SAE1 RWDD3 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling CDC37 ERBIN ERBB2 HSP90AA1 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway IRS1 PIK3R2 PIK3CB PIK3R1 JAK2 IL2RG JAK3 FRS2 SHC3 PIK3CA PTPRA ITGB3 SPTB KSR1 IL5RA KSR2 FGB FGA FGG KRAS EGF ERBB2 EGFR SPTBN4 GRIN2B PPP1CB SPTBN5 PPP2R1A GFRA3 VCL RASGRP3 IL6 SPTA1 PPP5C IQGAP1 UBA52 BRAP ANGPT1 GOLGA7 SHC1 PSMD12 PSMD11 UBB TEK PSMD14 MRAS PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PRKCQ PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 LYPLA1 PSMB3 PSMD2 PSMD3 PSMB1 RASGRP1 PSMD1 RASGRP4 CDK1 ADRM1 DUSP5 PSMA5 DUSP2 SEM1 DUSP1 PSMA6 DUSP16 PAQR3 PSMA3 DUSP10 DUSP4 PSMC5 PTPN7 PSMA4 PSMC6 BCL2L1 DUSP6 DUSP7 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MAP3K11 DLG1 RASGRF2 PDGFRA YWHAB RAF1 FGF6 SHOC2 JAK1 TYK2 MARK3 IL3RA SRC CSK MAP2K1 MAP2K2 RAP1A RBX1 MAPK1 IL2RA BRAF ZDHHC9 ABHD17C MAPK3 USP17L2 FGF1 FRS3 ABHD17B FGF4 ABHD17A RCE1 SHC2 FGF16 RALGDS FGF9 FGF18 FGF20 SPTBN2 SOS1 FGF23 LAMTOR2 SPTBN1 LAMTOR3 PTK2 TGFA SPTAN1 SPRED3 SPRED2 PTPN3 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 FYN ICMT IL2 PPP1CC IL3 FLT3LG PDGFB FLT3 KLB RANBP9 PDGFRB FGF19 FGFR4 PTPN11 EPGN ARRB1 FN1 CALM1 PRKG2 DUSP8 DUSP9 FNTA FNTB WDR83 RGL3 RGL2 PEA15 RGL1 IL17RD RAPGEF2 RASGEF1A ACTN2 CSF2RB CSF2RA ARL2 GRIN2D CSF2 DLG2 ITGA2B DLG3 CNKSR2 IRS2 CNKSR1 DLG4 RASGRF1 PEBP1 IL6R NEFL LRRC7 ARRB2 APBB1IP GRIN1 RAP1B HGF MET AREG FGF7 FGF22 MAPK12 FGF3 FGF10 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA TLN1 PPP2CB PPP2R1B PPP2R5E IL5 PHB1 NRG1 NRG2 EREG BTC IL2RB NRG3 NRG4 RET HBEGF KIT NRTN FGF2 NCAM1 PSPN GFRA2 GFRA4 ARTN VWF PDE6D ARAF GFRA1 CAMK2B CAMK2D CAMK2A GDNF CAMK2G KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway CUL3 SOD3 MYC SQSTM1 SRXN1 CCL2 CREBBP NQO1 PGD EGF UBXN7 ABCG2 BTRC DPP3 RELA SKP1 ABCF2 CDKN2A NFKB1 UBA52 AKT2 AKT3 ABCC3 ABCC1 CUL1 FBXL17 BACH1 PSMD12 PSMD11 UBB CHD6 NOTCH1 PSMD14 PSMD13 UBC SLC7A11 PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PALB2 PSMB1 PSMD1 ADRM1 EP300 PSMA5 SEM1 BCL2 PSMA6 PSMA3 PSMC5 PSMA4 G6PD BCL2L1 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 TXN SKP2 SP1 EIF2AK3 MAP1LC3B AKT1 GCLC PRKCD PDGFA PRDX1 MAFK AREG TXNRD1 GCLM NFE2L2 PRKCI CSNK2A1 GSK3B CSNK2A2 AMER1 CDKN1A CSNK2B BRCA1 KEAP1 PRKAA2 TRIM21 GSTA3 RBX1 GSTA1 HMOX1 SESN1 MUL1 ME1 TALDO1 SESN2 IDH1 MAFG ATF4 TKT NPLOC4 VCP UFD1 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells CAPZB HLA-DQB2 DYNC1LI1 HLA-DRB1 DYNC1LI2 HLA-DQB1 KIF23 KIF22 KIF2A KIF2C KIF2B DYNC1I1 CENPE OSBPL1A KIF26A CAPZA1 CAPZA2 DYNLL2 ACTR1A CTSV CTSS CTSL CTSK RAB7A CTSA KIF5C KIF5B KIF5A CTSD CTSB DYNLL1 KIFAP3 DCTN1 KIF20A IFI30 KLC1 SPTBN2 DYNC1I2 DCTN2 KLC4 DCTN3 KLC3 CTSO KLC2 KIF3A ACTR1B KIF3B CTSH RACGAP1 CTSF CTSE KIF3C CTSC HLA-DMA HLA-DMB KIF18A CAPZA3 ACTR10 HLA-DOA KIF4B HLA-DOB KIF4A HLA-DQA2 DYNC1H1 HLA-DQA1 HLA-DPA1 HLA-DRB5 HLA-DRB4 DCTN6 DCTN5 KIF11 DCTN4 HLA-DPB1 KIF15 HLA-DRA HLA-DRB3 RILP REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NEUROG3 NEUROD1 NKX2-2 PAX4 INSM1 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex KMT2A PER2 PER1 NPAS2 CLOCK PER3 CSNK1D BMAL1 CRY2 CSNK1E CRY1 CREBBP NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression H2AC14 ERCC3 H2BC12L SAP130 H2AC8 ERCC2 H2AC6 H2AC7 SAP30BP SAP30 DNMT1 BAZ2A H4C9 SUDS3 SMARCA5 CDK7 H2AC20 MNAT1 H2AX H2BC26 SIN3B SIN3A H2BC21 H3-3B DNMT3B H3C8 UBTF TBP H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2AJ POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 H3C15 HDAC1 H2BC9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 MBD2 TAF1C H2BC1 GTF2H1 GTF2H2 SAP30L GTF2H3 TAF1A GTF2H4 POLR2E GTF2H5 POLR2F SAP18 POLR2H CCNH H2AC19 POLR2K POLR2L H2AB1 ARID4B H2AZ2 TTF1 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle ARHGDIA ARHGDIB RAB7A CAV1 ZAP70 DBT WDR11 DBN1 TMEM59 NSFL1C VANGL1 UACA PAK2 STOM JUP PAK1 SLC4A7 PAK6 PAK5 PAK4 OSBPL11 LAMTOR1 NIPSNAP2 MTR LCK SLC1A5 TFRC RALGAPA1 ROCK2 FAM91A1 VAMP3 ARHGDIG VCP ROCK1 RHOH TUBA1B CSK GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation IHH EOMES TBXT TBPL2 GSC NANOG MIXL1 SNAI1 CREBBP NOG TFAP2A TFAP2B TFAP2C FOXF1 ZEB2 TCF7L2 SHH TEAD2 TEAD4 FOXA1 KAT2B KAT2A CXCR4 MESP2 PSMD12 PSMD11 NOTCH1 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 PSMB6 PSMD8 FGF8 LFNG PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 SOX17 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES7 EPHA4 MSGN1 ADRM1 TBX6 EP300 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 RIPPLY2 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 CDH1 MAML2 MAML1 PAX6 ZNF521 MAML3 FOXA2 NOTO TCF7L1 WNT3A DLX5 PAX3 POU5F1 SOX2 PAX7 SNW1 ZIC1 MYB MAMLD1 MSX1 FGF4 GATA6 FOXC2 TRIM33 GATA4 FOXC1 FGF2 FGFR1 SMAD2 TCF7 SMAD4 SMAD3 OSR1 SOX1 ZIC2 PAX2 OTX2 BMP4 POU3F1 PAX8 LHX1 YAP1 FOXH1 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MOGS MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport CP CTNS SLC16A1 SLC6A7 SLC12A3 SLC12A1 RUNX1 SLC11A1 SLC12A6 SLC5A8 SLC2A8 PDZD11 SLC2A9 SLC5A5 SLC6A5 SLC6A2 SLC6A3 SLC43A2 SLC43A1 SLC2A10 SLC1A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC22A3 SLC1A6 SLC22A8 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC38A1 SLC6A19 SLC17A8 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC6A4 SLC7A9 SLC24A1 SLC24A4 SLC11A2 SLC5A6 BSG SLC3A2 SLC5A7 SLC16A8 SLC10A6 SLC16A3 AVP SLC20A2 SLCO4C1 SLC47A2 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC9A1 SLCO1B1 SLC30A3 SLC30A2 SLC6A12 SLC39A10 SLCO1B3 SLC6A11 SLC2A13 SLC30A1 SLC39A14 SLC5A11 SLC5A3 SLC39A6 SLC39A5 FGF21 SLC32A1 SLC39A8 SLC6A13 SLC39A7 SLC39A2 SLC6A1 SLC39A1 SLC15A1 SLC39A3 SLC15A3 SLC15A4 RSC1A1 SLCO1A2 SLC34A3 SLC34A2 SLC34A1 SLC25A18 SLC25A10 SLC35A1 SLC25A4 SLC25A11 SLC17A5 SLC25A1 SLC22A6 SLC5A12 SLCO2B1 SLC16A2 SLC13A5 SLC13A2 SLC13A3 SLCO1C1 SLCO4A1 SLC26A7 SLC26A9 SLC26A6 SLC25A22 SLC26A11 SLC5A9 SLC60A2 SLC30A10 SLC5A4 SLC26A2 SLC2A14 SLC26A1 SLC2A11 SLC2A12 SLC17A1 SLC13A1 SLC13A4 SLC5A10 SLC45A3 SLC20A1 SLC31A1 SLC41A2 SLC41A1 SLC2A6 SLC2A7 SLC8A3 SLC50A1 SLC22A2 SLC22A1 SRI SLC6A9 CALM1 SLC17A6 SLC8A1 SLC7A5 SLC17A7 SLC8A2 SLC2A1 SLC2A2 SLC2A3 SLC30A8 SLC30A5 ARL2 SLC27A1 SLC35B3 SLC67A1 SLC35B2 SLC4A1 SLC16A7 EMB SLC4A4 SLC22A4 SLC22A5 SLC35D1 SLC35D2 SLC4A7 SLC39A4 SLCO2A1 LCN9 SLC35B4 LCN15 LCN12 SLC26A4 APOD SLC26A3 SLC35A2 SLC35A3 SLC33A1 SLC35C1 ARL2BP LCN1 SLC29A4 SLC27A6 SLC2A4 SLC28A2 SLC25A5 SLC29A1 SLC28A1 SLC29A3 SLC27A4 SLC29A2 SLC28A3 SLC25A6 SLC24A5 SLC22A12 SLC24A2 SLC24A3 SLC8B1 SLC36A4 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLC44A5 SLC9A2 SLC9A3 SLC44A3 SLC9A4 SLC44A4 SLC9A5 SLC44A1 SLC9A6 SLC44A2 SLC9A7 SLC40A1 SLC9A8 SLC9A9 HEPH SLC5A1 SLC5A2 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling VAV2 PSEN2 LYN MYL6 APH1A APH1B MYL9 NGEF FYN CLTB ARPC4 ARPC5 MYH9 ARHGEF7 ARPC2 ARPC3 CLTCL1 PAK1 CDC42 LIMK2 LIMK1 EPHB6 ADAM10 NCK2 EPHB2 PAK3 ARPC1B EPHB1 ARPC1A EPHB4 PSENEN GRIN1 ACTR3 EPHB3 EPHA5 ACTR2 EPHA7 EPHA6 EPHA8 PSEN1 CLTC CLTA AP2A1 EPHA1 EPHA3 AP2B1 NCSTN GRIN2B AP2A2 DNM1 EPHA10 MYL12A SDCBP ROCK2 AP2S1 TIAM1 ACTG1 ROCK1 EFNA5 EFNA4 RAC1 EFNB2 EFNB1 EFNB3 CFL1 EFNA1 RHOA EFNA3 EFNA2 ARHGEF28 MMP2 PAK2 MMP9 WASL EPHA2 MYH14 MYH11 KALRN MYL12B MYH10 PTK2 ITSN1 GIT1 SDC2 YES1 VAV3 HRAS EPHA4 ACTB RASA1 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 ABCA3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation L3MBTL1 EP300 TP53 PRMT5 UBB UBC KMT5A RPS27A JMY MDM2 ATM MDM4 CHEK2 UBA52 SMYD2 SETD9 EHMT2 EHMT1 TTC5 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE1 RB1 CDK2 CCNE2 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells CBFB RUNX1 LGALS3 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins H2AC14 H2BC12L OST4 OSTC STT3A MYC MDM2 MYCN PIP5K1C PRKCSH TNRC6C JUP MOV10 AGO3 TCF3 AGO4 AGO1 AGO2 SNAI1 DDOST SNAI2 CTNNA1 TNRC6A TGIF2 DAD1 TNRC6B H4C9 STRAP SMARCA4 GANAB TFAP2A H2AC20 FOXQ1 DNTTIP1 ZBTB33 EZH2 FOXP2 H2AX ZEB2 PKM ZEB1 POMT2 MCRIP1 FOXJ2 KLF9 POMT1 H3-3B VCL H3C8 TCF12 SIRT1 H2AJ UBA52 ZNF217 H3C15 PSMD12 PSMD11 UBB PSMD14 PSMD13 SUZ12 UBC H2BC9 H2BC8 H2BC5 ARHGAP32 PSMA7 MOGS H2BC3 PSMB6 RPS27A PSMD8 H2BC1 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 RPN2 PSMB2 PSMB3 PSMD2 PSMD3 RPN1 PSMB1 PSMD1 MPHOSPH8 H2AB1 ADRM1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 H2AC8 PSMC6 H2AC6 PSMC3 H2AC7 PSMA1 PSMA2 PSMC4 PSMC1 CTBP2 PSMC2 CTBP1 CTNNB1 CDH1 ZMYM2 SP1 CTNND1 MTBP RACK1 CBLL1 BANP EPS15 SEC11A SEC11C DNM2 SRC CSNK2A1 PCSK6 FOXA2 CSNK2A2 CANX CSNK2B CTSS H2BC26 KLF4 H2BC21 CTSL KDM1A TWIST2 EED TWIST1 CTSB ARID1A H2BC17 SPCS3 MAPK1 SPCS2 H2BC12 SPCS1 H2BC13 H2BC14 MAPK3 H2BC15 H2BC11 TLE1 HDAC2 FURIN PCSK7 HDAC1 CSNK2A3 ANK3 TMEM258 KMT5A RBBP4 RB1 RBBP7 H2AC19 WT1 H2AZ2 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA NUP62 RAN NUP37 NDC1 SEC13 NUP133 NUP107 NUP188 RCC1 RANGAP1 NUP50 NUP54 NUP210 NUP93 XPO1 NUP205 POM121 NUP214 NUP42 AAAS NUP160 POM121C NUP85 NUP43 TPR NUP88 RAE1 RANBP2 NUP155 RANBP1 NUP153 NUP35 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) EBP DHCR24 LBR TM7SF2 SC5D CYP51A1 MSMO1 DHCR7 HSD17B7 NSDHL TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EPC1 PHC3 E2F6 MGA EED MAX CHEK1 UXT PCGF6 PCGF2 BMI1 RRM2 RYBP CBX5 APAF1 CBX3 SUZ12 RING1 L3MBTL2 RBBP4 TFDP1 TFDP2 RNF2 RBBP8 EZH2 YAF2 CDC7 RBBP7 E2F1 EHMT2 EHMT1 PHC1 BRCA1 RAD51 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling DCC TRPC7 PITPNA PLCG1 TRPC5 NTN1 TRPC6 TRPC3 TRPC4 TRPC1 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CHEK2 CHEK1 PLK3 GSK3B BTRC MAPK14 SKP1 MAPK11 FBXW11 NEK11 CSNK1E RBX1 UBA52 CUL1 PSMD12 CSNK1A1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations DAG1 POMGNT1 POMT2 POMT1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development CALM1 NCOR2 GPS2 TBL1X HDAC3 HDAC1 PRKACA NCOR1 CAMK4 TBL1XR1 SIN3A FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm EP300 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 RIPPLY2 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 TBXT CREBBP NOG MAML2 MAML1 MAML3 WNT3A SNW1 MAMLD1 KAT2B KAT2A MESP2 FGFR1 PSMD12 PSMD11 NOTCH1 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 PSMB6 PSMD8 LFNG PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 BMP4 PSMD3 PSMB1 PSMD1 HES7 EPHA4 MSGN1 ADRM1 TBX6 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins SEC16A ST8SIA3 SEC23IP CNIH1 CNIH2 FOLR1 CNIH3 BET1 TNIP2 SPTB ANK2 SPTBN4 SPTBN5 LTF SPTA1 BGLAP LYZ DMP1 BPIFB2 SEMG1 PSMD12 PSMD11 PSMD14 MATN3 PSMD13 PSMA7 PSMB6 PSMD8 UBE2D3 TNC PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 FBN1 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CTNNB1 LAMB2 PCCB FOXO4 ATXN3 NUP214 PABPC1 FBXO32 HSPA8 EIF4G1 RBX1 L3MBTL2 SLC35A1 TGFA SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN SATB2 CUL3 KBTBD7 C3 NPPA NUP107 NUP188 NUP210 NUP93 NUP205 POM121 AAAS NUP160 POM121C NUP85 TPR NUP88 XRCC4 NUP155 NUP153 NUP62 ELOB ELOC NDC1 SEC13 NUP133 ZNF350 RANGAP1 NUP50 NUP54 PCGF2 NUP42 NUP43 TAF9B RAE1 RANBP2 TAF10 IGFBP1 NUP35 NUP37 VCAN GLB1 ARSB UBE2L6 IFIH1 TRIM25 IKBKG RIGI AMER1 AXIN1 KLF4 APC SPG7 AFG3L2 SMDT1 YME1L1 PMPCA MICU2 PARP1 GATA3 KCTD6 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMAD7 CGB8 BMP4 CAMKMT THBS1 HSPD1 HIF1A MYC PROS1 SERPINA10 FGA TGFB1 FGG F2 F5 F7 F8 F9 SERPINC1 PROZ KNG1 F10 SERPIND1 TFAP2B TFAP2C PROC EIF2AK2 TOPORS SEMA5A POMT2 UBE2D1 SPON2 SEMA5B RELA SPON1 THSD7B POMT1 ADAMTSL1 ADAMTS2 C1GALT1C1 ADAMTS3 ADAMTSL5 TCF7L2 ADAMTSL4 UBE2C ADAMTSL3 ADAMTSL2 CDKN2A MUC12 UBE2E1 MUC15 THSD7A IL6 UBE2S ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP ZDHHC2 THBS2 ADAMTS12 RPS15 THSD1 RPS14 THSD4 ADAMTS10 RPS17 ADAMTS15 RPS16 ADAMTS14 RPS19 MUC1 MUC2 ADAMTS19 RPS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 RPS11 GALNT3 B2M MUC17 MUC19 RPS10 RPS13 C1GALT1 SSPOP MUC5B RPS12 MUC20 MUC21 ST6GAL1 DNAJC3 MOGS HLA-A ACE2 RPS4Y2 PLAUR RPN2 SAR1B SDC2 PALB2 RPN1 RPS4Y1 GALNT2 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 EDEM2 RPS26 RPS25 RPS28 RPS27 RPS29 OTUB2 RPS20 OTUD5 RPS21 OTUD7A RPS24 VCPIP1 RPS23 ZRANB1 YOD1 TNIP1 RNF128 TNIP3 OTUB1 MAGT1 TRIM4 IKBKE TOMM70 RIPK2 SFTPD ANO8 CANX RPS27L RNF135 RPS15A MGAT5 RPS3 GPC3 MGAT1 RPS2 MGAT2 ASPH FAU TUSC3 MAP3K7 RPS9 RPS7 RPS8 ADRB2 RPS5 RPS6 RPSA TUFM TMEM258 VCP DDX5 FUT8 MAN2A1 GNAT3 NLRP3 OST4 ADORA2B MAVS OSTC STT3A UBE2N TAB1 STT3B ST6GALNAC2 PRKCSH RPS4X RPS3A DDOST DAD1 TRAF3 TRAF6 USP14 MAN1B1 ST6GALNAC3 USP18 ST6GALNAC4 BECN1 SEC23A SAA1 NOD1 NOD2 GANAB VHL SEC24B SEC24A GALNT1 MGAT4C MGAT4A ARRB1 MGAT4B SEC24D SEC24C CALM1 NAPA RAB5C TGOLN2 GBA1 DCAF7 CCT6B TUBB6 PENK TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 GOLGB1 FBXW10 FBXW7 FBXW9 SFTPB SFTA3 TUBA4B FBXW2 SFTPA2 SFTPC CCNE2 CCNE1 CSF2RB SFTPA1 XRN2 GAPDHS CSF2RA FKBP9 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A CISH GNB2 GNAQ GNB1 PRL TBCE PDCL GNB4 GNB3 FBXL3 SOCS2 GH1 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 KIF13A CCT3 CCT2 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 ARRB2 TUBAL3 USP11 AP3M1 TUBA3E GNA14 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 COP1 GNG4 GNG7 GNA11 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 RGS11 B4GALT1 TMED2 NOTUM SEL1L FUCA2 ST3GAL6 RAB6A LRR1 CCNF KEAP1 UBE2L3 HERC2 FBXO7 FBXO9 WSB1 FBXO2 RNF123 RHOA UBE2J2 SIAH2 SIAH1 EPAS1 FBXL8 FBXL4 SOCS3 FBXL7 GAN UBA2 SAE1 PRKN KLHL2 UBE2G1 KLHL3 UBE2G2 KLHL9 SPSB2 VNN1 SPSB1 VNN2 KBTBD6 KLHL5 KBTBD8 SPSB4 SRP14 FBXO27 LTN1 FBXO21 UBE2Z ADA2 FBXO22 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 AHSG LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB3D KLHL42 UBE2V2 RAB44 CUL7 CUL5 UBA6 CUL2 KLHL11 RAB37 RAB4B KLHL13 FBXO44 FBXO41 U2AF2 RAB24 FBXO40 BTBD1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 KLHL20 FBXO31 UBE2W COPB1 UBA3 UBA1 UBE2K UBE2M KBTBD13 UBE2Q2 UBE2R2 TRAF2 ASB13 ASB14 RIPK1 ASB11 ASB12 RNF7 UBE2D2 ASB17 RCHY1 ASB18 FBXL22 ASB15 FCGR3B FBXL21P ASB16 FBXL20 ASB10 FBXL19 FBXL18 CDC34 FBXL15 FBXL16 QSOX1 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 BCL10 ASB4 ASB5 ASB2 ASB3 ASB1 GOLGA2 CDC25A NFKBIA GRIA1 NSF ADORA2A MYO5A ABCE1 TGFBR1 TGFBR2 USP17L2 RCE1 RARS2 AARS2 FGF23 PARS2 MARS2 SLC34A2 DARS2 YARS2 SLC34A1 HARS2 FARS2 WARS2 LARS2 P4HB APOB SARS2 NARS2 CDC20 TARS2 IARS2 VARS2 CCNA2 CARS2 CCNA1 EARS2 NFU1 MT-CO1 LIPT2 LIPT1 KLK13 LIAS PIGS CPM LY6K PIGU HEMK2 PGAP1 PIGT PIGO PSCA GPAA1 PIGN PIGP PIGZ PIGW MSLN PIGV PIGY PIGX PRSS21 LARS1 PRND TECTA MT-CO2 TECTB CD52 MT-CO3 RTN4RL2 IZUMO1R PIGC PIGB SHMT2 CEACAM7 NRN1L RTN4RL1 PIGA CEACAM5 CD109 PIGK LY6D PIGM SPACA4 PIGL PIGG LY6H PIGF GPLD1 PIGH NRN1 NTM TEX101 LYPD1 USP30 LYPD2 SQSTM1 LYPD3 THY1 ZNF598 LYPD4 ASCC2 LYPD5 ASCC3 ART3 ART4 LYPD8 TRIM27 OTOA LY6G6C USP13 TNKS LY6G6D OPCML TNKS2 NTNG1 RNF146 NTNG2 OTUD3 NEGR1 CNTN5 GP2 LSAMP PLET1 PRSS41 XPNPEP2 RAET1G LYPD6B RAET1L ST6GALNAC1 ALPL CMAS CNTN3 NPL NANP CNTN4 NEU4 MELTF ALPG ST8SIA4 NANS MDGA2 ST6GAL2 ULBP2 MDGA1 ST8SIA1 RECK GNE SPRN EIF4A2 EIF4A1 SRP19 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 EIF4E EIF4B DLST GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 POFUT4 POFUT2 POFUT3 QTGAL EMID1 B3GALNT2 GALNTL5 GALNTL6 GALNT9 GALNT8 POMGNT2 B3GNT9 B3GNT8 MMRN1 B3GNT6 MMRN2 CHST4 GCNT1 MGAT5B GCNT3 GCNT4 TPST2 GCNT7 TPST1 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT POMK EIF5 RAB2A EIF5B PELO UQCRQ ACO2 MT-CYB ALAS1 PTEN ETFB PAX6 IAPP ALG5 NUDT14 ARF4 EXOC8 EXOC7 ECI1 GMPPB FPGT GMPPA STS GFUS EXOC4 ALG10 EXOC3 ALG10B EXOC6 FUOM EXOC5 DHRSX EXOC2 GMDS PMM1 EXOC1 FCSK DOLPP1 PPA2 MT-ND4L PPA1 MTRF1 GFM2 MRRF GBF1 MTRF1L CES1 RAB11A GOSR1 NEU2 NEU3 RAB41 NEU1 APOE ANKZF1 KLHDC10 NPLOC4 B4GALNT2 COG8 TCF25 UFD1 COG7 NEMF COG6 COG5 COG4 COG3 COG2 BET1L AIMP1 RAB30 RAB36 BST1 AIMP2 LTBP1 APH1A APH1B EPRS1 INHBB APOL1 INHBA CHRDL1 MT-ATP6 PSENEN MALSU1 UCHL5 EEF1E1 MIEF1 MTFMT MTIF2 MTIF3 MTRFR USP15 MTRES1 NEDD8 COX5B FSTL1 FSTL3 COX5A INHA GCG MT-ATP8 NDUFAB1 SMC3 RAD21 STAG1 STAG2 SMC1A NRIP1 NFRKB ACTR5 RAD23A ACTR8 RAD23B DDB1 INO80C INO80B INO80E PDHA1 INO80D COPS7B COPS7A XPC TFPT OTULIN INO80 CUL4A COPS3 COPS6 COPS5 COPS8 CUL4B PCSK9 OXCT1 ISL1 GSPT2 GSPT1 USP33 ETF1 EIF1AX EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I USP10 EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B CHCHD2 OXSM ECH1 CLPX CLPP LDHD ALDH18A1 OPA1 TIMM17A TIMM22 TIMM9 TIMM10 ST3GAL5 CGA RAB43 KDELR2 COPB2 COPA COPE TMED3 TMED7 TMED9 COPZ2 COPZ1 ARF5 COL7A1 ARCN1 COPG2 COPG1 RAB3A METTL21A KIN METTL22 EEF2KMT ETFBKMT SLC17A5 VCPKMT EEF1AKMT2 EEF1AKMT1 EDEM3 EDEM1 AMFR SYVN1 DERL2 RNF5 RNF103 RNF139 OS9 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 RPL10L RPL10A PSMD9 RARS1 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSMD10 PSMB11 IL33 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 USP17L4 USP17L5 USP17L8 USP5 USP3 RAB4A USP17L30 FKBP8 SNX3 USP37 USP34 USP47 USP48 USP49 USP42 RAB5A USP44 PTRH2 USP16 USP12 WDR20 USP17L21 USP17L20 FN1 USP17L22 USP19 USP24 HMGCS2 USP17L15 USP25 IDH3A USP17L18 USP26 USP17L17 USP20 USP17L19 USP17L10 USP17L12 APOA2 USP28 USP17L3 APOA1 USP17L11 LY6E RPL13A USP17L13 APOA4 USP17L1 APOA5 PDHB TTR C4A CALU ALG8 ALG9 ALG6 ALG2 ALG3 ALG1 SPP2 RAB14 CALR APLP2 SCG3 DHDDS RPL18A RPL36AL PDK1 SUCLG2 TFG CTBP1 HNRNPK LHB TXN WDR48 GAS6 RAB5B SKIC8 SEC11A SEC11C COG1 ATP5PF ATP5PD MIA2 MIA3 TMEM115 SPCS3 SPCS2 SPCS1 ATP5PO NDUFA13 ALG14 ALG13 ALG12 ALG11 HADH TTLL10 RPL9P9 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 NICN1 VASH2 VASH1 TTLL7 ATP5MG AGBL5 AGBL4 TTLL6 RFT1 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 TTLL1 IDH2 AGBL3 AGBL2 TTLL13 TTLL11 TTLL12 TTLL9 TTLL8 ABCA3 PMM2 CP HK1 DBT GGCX ALDH1B1 KDELR1 MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 CTR9 MT-ND1 RTF1 SEC31A PAF1 DERL1 DPAGT1 UQCRC2 MPI DOLK DCTN1 GPIHBP1 CS ARF3 ARF1 RPLP1 RPLP0 TRMT112 RPLP2 ARG2 MPDU1 SUMF2 SUMF1 BDH1 DLD VAMP2 FH KARS1 NUS1 MDH2 PDIA3 DPM1 DPM2 DPM3 RPL22L1 IDE ACAT1 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 SRD5A3 MRPL38 MRPS10 ATXN3L MRPL39 JOSD2 MRPL36 JOSD1 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 COX4I1 MRPL4 MRPL41 MRPL42 MRPL3 NADK2 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 ME2 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 ST6GALNAC5 MRPL46 ST6GALNAC6 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 NDUFB6 MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 HSD17B10 ABRAXAS2 MRPL58 MYSM1 MRPL14 MRPS30 STAMBPL1 STAMBP MRPL15 MRPL12 MRPL13 MRPL57 MRPL10 IARS1 MRPL54 MRPL55 MRPL11 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 NDUFA2 MRPL21 MRPL22 MRPL30 RPL23A HSP90B1 ARSA RNF152 SHPRH PEX2 RNF40 RNF144A SELENOS WAC PRKDC TMEM129 HLTF STX1A PEX10 PEX12 PEX13 UMOD PEX14 ASGR1 ASGR2 RNF181 ARSL RAD18 MANEA APEH ARSJ ARSK ARSH ARSI ST8SIA5 ARSF ARSG ARSD CTSA RPL27A LGALS1 EVA1A CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 ACAD8 IGFBP6 AMELX AMBN TMEM132A HRC PRSS23 BMP15 MEPE RCN1 ENAM AMTN FAM20C VWA1 FAM20A PAPPA2 ITIH2 AFP GOLM1 NUCB1 KGD4 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 FUT3 NDUFV3 NDUFV1 TRAPPC2L RAB32 RAB31 RAB22A TBC1D20 RAB35 RAB40A RAB40B RAB40C RAB3B RAB3C RAB38 RAB42 RAB2B RAB34 PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB29 RAB6B RAB15 RAB19 RAB17 TRAPPC2 PCMT1 MSRA TRAPPC3 TRAPPC1 DARS1 MSRB3 MSRB1 TRAPPC4 TRAPPC5 NDUFS3 RAB39A MVD RAB27A NDUFS1 RAB39B RAB27B TRAPPC9 MAT2B INS MBTPS1 RAB8B RPL26L1 RPL4 RPL5 RAB33A RPL30 RAB33B TRAPPC6A RPL3 RPL32 RPL31 TRAPPC6B RPL34 RAB7B RPL8 RAB1A RAB1B RPL6 RPL7 RAB21 GCSH GGA2 GGA1 RPL36 GGA3 RPL35 CHML TRAPPC10 RAB11B RPL38 RAB10 RAB12 RPL37 RAB13 RPL39 RAB18 RPL21 RPL23 RPL22 FDX1 ACOT2 RPL24 RPL27 RPL26 RPL29 RPL28 MITF RPL41 RPL3L GLUD1 CLSPN OGDH GSN RPL10 RPL12 RPL11 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 AGT MME FECH FFAR4 ALB GRP RPL7A ADRA2C ADRA2A SARS1 RPL37A RPL36A RPL35A FOLR2 VDAC1 P2RY2 PCSK1 CDX2 GPR119 GIP DPP4 LEP ANK3 RPL39L ACADSB STAR KDM8 QARS1 OGFOD1 EIF5A JMJD4 DHPS FN3KRP JMJD7 FFAR1 RCCD1 EIF5A2 DLAT DNAJC24 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 ZC3H15 B3GNT7 RWDD1 FN3K ICMT B3GNT5 DOHH B3GNT4 RIOX1 DRG1 B3GNT3 DRG2 B3GNT2 CPB2 ATP5F1A ATP5F1B ATP5F1C CD59 CD55 OXA1L HSPA9 B4GALT2 B4GALT3 POLB ALDH2 PCSK2 UCN ERO1B CTSZ ANPEP TSHB CPA3 SLC30A8 FSHB SLC30A5 ATP6AP2 MYRIP ENPEP CPB1 PLA2G7 MARS1 CRHR2 CLTRN ACE IGF1 MBOAT4 INHBC INHBE GZMH B4GALT6 CPE REN B4GALT4 B4GALT5 SMC5 SMC6 PARK7 DDX17 NSMCE3 NSMCE2 NSMCE1 HIC1 EID3 ZBED1 TP53BP1 SP3 TOP2A POMC TOP2B ZNF131 SENP5 FOXL2 SENP2 SAFB APP RNF168 NSMCE4A TOP1 NFKB2 SP100 UHRF2 CASP8AP2 NOP58 RWDD3 MBD1 RAD52 SKP2 AARS1 UBXN1 HARS1 NGLY1 YARS1 MLEC WARS1 ENGASE GARS1 NARS1 CARS1 FARSA TARS1 VARS1 FARSB AREG NFE2L2 EEF1B2 EEF1G EEF1A1 EEF1D EEF1A2 EEF1A1P5 CDH2 EEF2 USP8 KIF5C KIF5B KIF5A GATA6 GATA4 UBE2T CAPZB CAPZA1 CAPZA2 EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 HGS RAB7A TFAM TWNK PSME2 SSBP1 IGF2 PSME1 SEC61A2 SEC61A1 SEC61G SEC61B SEC22B PSMB10 MDC1 PSMB8 PSMB9 DAXX RRAGA BARD1 PRELID1 CDKN1A CHM BRCA1 ING2 VGF DDB2 PCNA WRN NPM1 RPA1 SPTBN2 HIPK2 CTSH CTSC CAPZA3 ACTR10 USP7 IGFBP3 USP2 BLM DCTN6 DCTN5 DCTN4 TOMM20 VDAC3 VDAC2 MDM2 MDM4 TRIAP1 RABGGTB RABGGTA BIRC5 UCHL1 AURKB SENP8 UCHL3 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 BAP1 PML TRRAP H2AC17 H2AC12 JMJD6 TADA2B H2AC25 H2AC21 PRMT3 ANK1 KDM1B TUBB8 TUBB8B RUVBL1 MAN1A2 MAN1C1 MAN1A1 H2AC1 PIAS4 ATXN7 HDAC4 PIAS3 THRB UBE2I VDR NR1H2 RIOX2 RORA NR3C1 ESR1 NR2C1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 H2BC18 SUMO2 RARA PPARG PGR PPARA USP22 TP53 SLC35C1 SLC25A5 CSNK2A1 STARD7 CSNK2A2 SLC25A6 DCAF13 CSNK2B MUC13 CKAP4 KTN1 MUL1 ALPI ARFGAP1 ACHE ADAMTS13 PREB KDELR3 OMA1 HTRA2 MRTFA GOSR2 DYNC1LI1 DYNC1LI2 CDCA8 SSR1 BCHE HIF3A RHOT1 HNRNPC IGFBP7 WFS1 PNPLA2 DYNLL2 CETN2 LRRC41 CCP110 INCENP ACTR1A LONP1 TUBA1A SERP1 UBXN7 BTRC GPS1 PRKACA PDIA6 DPP3 RAB8A LMAN1 SKP1 SRPRA SRPRB STX5 FBXW11 YKT6 CSNK1D USP9X BRCC3 BABAM1 BABAM2 UIMC1 DYNLL1 ABRAXAS1 TUBA4A UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA UBB UBC RPS27A DYNC1H1 TUBB4B TUBB4A CDK1 STAT3 COPS4 COPS2 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 ADAM10 DCUN1D5 DCUN1D3 HSPG2 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 COMMD9 PUM2 DDA1 ANKRD9 COMMD2 ARFGAP3 COMMD3 COMMD1 KLK2 ARFGAP2 COMMD6 COMMD7 ADAMTS16 COMMD4 COMMD5 NCSTN SPSB3 CCDC8 ADAMTS18 CUL9 UBD NAE1 SOCS6 WDTC1 SOCS5 CCDC22 COMMD10 DTL TULP4 DCAF16 LAMC1 DCAF17 CAND1 FEM1C ADAMTS4 DCAF10 ADAMTS5 DCAF11 FEM1A FEM1B RNF20 NEURL2 ERCC8 ADAMTS1 CTSG TIMP1 ADAMTS8 ADAMTS9 CTSD MMP1 MMP2 CFTR KLK3 SCFD1 SPTBN1 PLG FURIN STAM SPP1 CMA1 LAMB1 SPTAN1 H2AC19 ACTB H2AC14 TRIM28 H2BC12L HCFC1 PPARGC1A CREBBP DYNC1I1 H4C9 RAB9A H2AC20 RAB9B H2AX CALB1 NAT8B BACE1 MFGE8 APCS CALCA TSPAN33 CST3 TSPAN5 H3-3B SNCA NCOA1 H2AZ1 NCOA2 ODAM H3C8 SNCAIP SORL1 TSPAN15 TSPAN14 NAT8 ACTL6A TGFBI ITM2B STAM2 NCOR2 KAT2B KAT2A H3C15 SUZ12 H2BC9 H2BC8 H2BC5 MCRS1 H2BC3 H2BC1 H2AB1 TTF1 EP300 MEN1 SENP1 H2AC8 H2AC6 H2AC7 DNMT1 SUDS3 TF BMI1 CBX5 YY1 RING1 TADA3 SATB1 RNF2 OGT HDAC7 CBX8 PHC2 CHD3 PHC1 H2BC26 CBX4 CBX2 SIN3A H2BC21 PHC3 DNMT3B NAGK WDR5 GFPT2 AMDHD2 GFPT1 PGM3 GNPNAT1 UAP1 DNMT3A RENBP H2BC17 TNFAIP3 H2BC12 OTUD7B H2BC13 H2BC14 H2BC15 USP4 USP21 H2BC11 CYLD BIRC2 BIRC3 CDC73 HDAC2 AXIN2 HDAC3 HDAC1 LEO1 MTA1 MCFD2 SERPINA1 PPP6C RBBP5 PPP6R1 TDG PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB TMED10 RBBP7 LMAN2L CSF1 STX17 USO1 MAN2A2 NAPG MGAT3 ST8SIA6 LMAN2 CHST8 SEC31B FUCA1 ANKRD28 SEC16B ST8SIA2 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 IHH MSX2 BMP2 PPARGC1A PPARGC1B RBM14 CCND1 CBFB RUNX1 COL1A1 UCMA BAX SKP1 HEY1 HEY2 BGLAP UBA52 AKT2 AKT3 CUL1 WWP1 PSMD12 CCNB1 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 CDK1 ADRM1 ESRRA PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 HDAC4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 NR3C1 PSMC2 ESR1 SKP2 AR DLX6 ABL1 AKT1 MAF ZNF521 SRC HDAC6 SP7 GSK3B CDKN1A NKX3-2 DLX5 HAND2 ITGA5 PPM1D GLI3 GLI2 SOX9 TWIST2 TWIST1 STAT1 RBX1 MAPK1 MAPK3 STUB1 LGALS3 MMP13 SMAD1 HDAC3 SMAD4 CDK4 SMURF1 SMAD6 HIVEP3 RB1 WWTR1 YES1 ITGBL1 HES1 YAP1 SATB2 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress NOX4 SOD3 CCS PRDX3 MYC PRDX6 COX7B COX7C ATP7A SRXN1 CCL2 GPX3 COX8A GPX6 GPX5 COX8C GPX8 GPX7 EGF TXNRD2 COX5B COX5A UBXN7 BTRC HBA2 RELA COX6C DPP3 SKP1 ABCF2 CDKN2A NFKB1 COX6A1 COX6A2 TXN2 UBA52 COX6B2 SOD2 SOD1 COX6B1 ATOX1 AKT2 AKT3 CUL1 FBXL17 BACH1 PSMD12 PSMD11 UBB CHD6 NCF1 NOTCH1 PSMD14 NCF2 PSMD13 UBC NCF4 SLC7A11 PSMA7 HIGD1C PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PALB2 PSMB1 PSMD1 ADRM1 PSMA5 STAT3 SEM1 BCL2 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 BCL2L1 ALB PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 GPX2 GPX1 MAP1LC3B TGS1 AKT1 FABP1 PRDX2 PRKCD PRDX1 TXNRD1 CARM1 CDKN1A BRCA1 COX7A2L RBX1 HMOX1 HMOX2 COX4I1 COX4I2 ME1 P4HB SESN2 MT-CO1 TKT VCP CUL3 MT-CO2 NLRP3 MT-CO3 MED1 SQSTM1 CREBBP NQO1 CAT PGD ABCG2 COX7A2 COX7A1 NCOA1 NCOA2 CYBB CYBA NCOA6 NCOR2 NCOR1 GSTP1 ABCC3 ABCC1 TBL1X EP300 G6PD TBL1XR1 TXNIP TXN SKP2 HELZ2 RXRA SP1 EIF2AK3 PPARA GCLC PDGFA MAFK AREG CYCS GCLM NFE2L2 CHD9 PRKCI CSNK2A1 GSK3B CSNK2A2 AMER1 CSNK2B KEAP1 SIN3A BLVRB BLVRA PRKAA2 TRIM21 GSTA3 GSTA1 NOX5 ERO1A SESN1 MUL1 COXFA4 HM13 STAP2 NUDT2 TALDO1 PTK6 HDAC3 SMARCD3 AQP8 IDH1 MAFG ATF4 NPLOC4 HBB UFD1 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling IFNL2 STAT3 IFNL1 IFNL3 JAK2 IL20RA IL20RB IL22RA2 STAT1 STAT4 STAT2 JAK3 IL22RA1 IL10RB JAK1 IL20 IL26 IL24 TYK2 IL22 IL19 PTPN11 STAT5A STAT5B IFNLR1 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles HMGA1 BANF1 PSIP1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly SMN2 NUP37 NUP107 NUP188 NUP210 NUP93 TGS1 NUP205 POM121 NUP214 DDX20 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 PHAX CLNS1A SNUPN NUP62 PRMT5 WDR77 NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP50 NUP54 GEMIN2 SNRPD2 SNRPD1 SNRPD3 NUP42 GEMIN4 SNRPG NUP43 GEMIN5 GEMIN6 SNRPE RAE1 GEMIN7 RANBP2 SNRPF GEMIN8 SNRPB NUP35 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors GP9 KLKB1 F9 GP1BA KNG1 GP1BB F12 F11 GP5 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling IL4 ALOX5 IL37 IL13 IL18BP IL18R1 IL18RAP IL18 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A ADAMTS6 ADAMTS8 ADAMTS7 SBSPON ADAMTS9 ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS19 ADAMTS17 POFUT2 SSPOP ADAMTS13 ADAMTS16 ADAMTS18 SEMA5A SPON2 SEMA5B THBS1 SPON1 THSD7B ADAMTSL1 ADAMTS4 ADAMTS2 ADAMTS5 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis PSMA5 SEM1 PSMA6 PSMA3 PSMC5 OPA1 ARHGAP10 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 PAK2 UBA52 PSMD12 PSMD11 UBB PSMD14 PSMD13 UBC PSMA7 PSMB6 RPS27A OMA1 PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2R1 LPGAT1 LPCAT1 PLA2G3 PLA2G4F PLA2G12A PLA2G5 PLA2G2F PLA2G4D PLA2G2D PLA2G2E PLA2G4B PLA2G4A PLA2G2A LPCAT4 CRLS1 PLA2G10 PLA2G1B RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter TBP BDP1 POLR1C POLR1D CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR2E POLR3G POLR2F POLR3H GTF3C1 POLR3K GTF3C2 POLR2H GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR2K POLR2L BRF1 GTF3A INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion ANO10 FURIN ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ACE2 ANO3 ANO1 TMPRSS2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network IRS1 PIK3R2 PIK3CB PIK3R1 FYN FRS2 PIP5K1A PIP5K1B PIP5K1C PIK3CA IER3 MYD88 FLT3LG PDGFB CD19 CD28 IRAK4 STRN FLT3 GAB2 TRAF6 PHLPP2 PHLPP1 IL33 CD86 KLB CD80 EGF ERBB2 PDGFRB FGF19 EGFR FGFR4 IL1RL1 TRAT1 PIK3AP1 PTPN11 EPGN PPP2R1A PIK3R3 PIK3R6 PIK3R5 AKT2 AKT3 IRS2 ESR1 INSR PDGFRA FGF6 AKT1 HGF GAB1 MET PTEN AREG LCK SRC FGF7 FGF22 FGF3 FGF10 PPP2R5B NTRK2 BDNF PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB PPP2R1B PPP2R5E THEM4 RAC1 NRG1 INS NRG2 EREG BTC MAPK1 NRG3 MAPK3 FGF1 NRG4 FGF4 FGF16 FGF9 FGF18 HBEGF FGF20 PIK3CD FGF23 PIK3CG KIT NTRK3 FGF2 PIP4K2A TRIB3 ESR2 PIP4K2B PIP4K2C TGFA RAC2 NTF3 RHOG IRAK1 VAV1 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation PTPN1 SRMS PTK6 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation RPL24 RPL27 RPL26 RPL29 RPL28 RPS26 RPS25 RPS28 RPS27 RPS29 RPL7A RPS20 RPL10L RPS21 RPL10A RPS24 RPS23 RPS4X RPL41 RPS3A RPL3L RPL37A RPL23A RPL36A RPL35A RPL22L1 RPS27L RPL10 RPS15A RPL12 RPL11 RPS3 RPL14 RPL13 RPL15 RPL18 RPS2 RPL17 RPL19 RPL13A RPL27A RPS15 RPL26L1 RPS14 FAU RPL4 RPL5 RPS17 UBA52 RPL30 RPS16 RPL3 RPL32 RPS19 RPL31 RPS18 RPL34 RPS9 RPL9P9 RPS7 RPL8 RPS8 RPS11 RPS5 RPL6 RPL7 RPS10 RPS13 RPS6 RPL36 RPS12 RPSA RPL35 RPL39L GRSF1 RPLP1 DNAJC3 RPLP0 RPL38 RPS27A RPL37 RPL39 RPLP2 RPS4Y2 RPL21 RPL18A RPL23 RPL36AL RPL22 RPS4Y1 KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF13B KIF1C KIF1B KIF28P KIF1A KIF25 KIF23 KIF22 KIF5C KIF6 KIF5B KIF5A KIF27 KIF21A KIF21B KIF9 KIFAP3 KIFC2 KIF2A KIF16B KIFC1 KIF20A KIF20B KIF2C KIF2B KLC1 KLC4 KLC3 KLC2 KIF3A KIF3B CENPE RACGAP1 KIF26A KIF3C KIF26B KIF18A KIF18B KIF4B KIF4A KIF12 KIF11 KIF15 KIF19 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes EP300 BACH1 SOD3 CHD6 GCLC PRDX1 MAFK TXNRD1 GCLM NFE2L2 SLC7A11 GSTA3 GSTA1 HMOX1 TXN ATF4 SRXN1 NQO1 CREBBP PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH2 NOTCH3 NOTCH1 NOTCH4 POGLUT1 POFUT1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R IRS1 PIK3R2 PIK3CB NRAS PIK3R1 THEM4 IRS4 FRS2 PIK3CA FGF1 FGF4 FLT3LG FGF16 FGF9 PDPK1 FGF18 FGF20 SOS1 FGF23 TLR9 FLT3 AKT2 GAB2 FGF6 FGF2 PIK3C3 KLB GAB1 IGF2 FGF19 IGF1 FGFR4 TRIB3 PTPN11 IRS2 FGF7 PDE3B IGF1R FGF22 FGF3 FGF10 PIK3R4 HRAS BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations FDX2 CYP26A1 OPLAH CYP2R1 CYP3A43 ACY3 ACY1 ALDH1A1 UGP2 ALDH1B1 CYP1A1 CYP2C9 CYP2C8 CYP2D6 AHCY UXS1 CYP1A2 CYP2E1 CYP3A4 AS3MT CYP8B1 AOC3 AKR7A2 AOC1 AKR7A3 AOC2 FMO1 FMO2 FMO3 CYB5R3 CYP2B6 SULT6B1 AHR ABHD10 NNMT GLYATL3 GLYATL2 GLYATL1 AIP GLYAT TRMT112 NAT1 CYP4F22 NAT2 ESD UGT3A2 PODXL2 UGT3A1 CYP4A22 CYP26B1 CYP4F11 CYP4F12 CYP4A11 CYP26C1 PTGS1 CYP2F1 ACSS2 ACSS1 AADAC GGT3P UGT1A10 HPGDS ACSM1 ACSM5 ACSM4 CHAC2 CHAC1 CYP19A1 ADH7 CMBL CYP27A1 ADH5 ADH6 ADH4 GGCT MTARC2 MAOB MTARC1 MAOA MGST3 MGST1 MGST2 CYP27B1 ARNT CYP2A7 CYP2A6 GSTT2B HEMK2 GSTK1 AHRR GSS NR1H4 SULT1A1 TPMT CYB5B HSP90AB1 SULT1A4 SULT1A3 SULT1A2 GSTM4 GSTM3 GSTM2 GSTM1 CYP4F2 AKR7L CYP4F3 CYP4F8 SULT1B1 ARNT2 NQO2 GSTM5 SULT1C2 ALDH3A1 SULT1C4 GSTO2 GSTO1 EPHX1 NCOA1 NCOA2 CYP21A2 UGT1A1 ALDH2 CYP4V2 BPHL GSTP1 CYP3A5 CYP3A7 UGT1A5 UGT1A3 SULT1E1 UGT1A9 PTGIS UGT1A8 UGT1A7 UGT1A6 CYP51A1 AKR1A1 CYP2A13 MTRR UGT2B10 UGT2B11 UGT2B15 UGT2B17 TPST2 TPST1 BPNT2 BPNT1 CYP46A1 GSTT2 POMC GGT1 GSTT1 CYP2C19 CYP2C18 POR MAT1A CYP2U1 DPEP2 DPEP1 SLC35D1 SLC35D2 RXRA CYP11A1 TBXAS1 GGT5 CYP2S1 GGT7 GGT6 UGT1A4 CYP7B1 UGDH GCLC CYP11B2 ADH1C CYP11B1 ADH1B ADH1A GCLM ACSM2A MTR ACSM2B UGT2A3 UGT2A2 CYP7A1 UGT2A1 SULT4A1 ABHD14B UGT2B4 CBR3 UGT2B7 PTGES3 PAOX UGT2B28 MAT2B CYP2W1 GSTA5 GSTA4 GSTA3 MAT2A GSTA2 GSTA1 CYP24A1 CYP4B1 GSTZ1 COMT CNDP2 FDXR CYP39A1 CYP1B1 CES3 CYP2J2 CES2 CES1 SULT2A1 FDX1 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMA5 SEM1 PSMA6 PSMA3 PSMC5 TACC3 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 RBX1 UBA52 CUL1 AKT1 PSMD12 PSMD11 UBB PSMD14 PSMD13 YWHAZ UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 NOTCH4 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 SKP1 ADRM1 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC ABHD3 CHAT CEPT1 BCHE CHKB CHKA STARD10 PEMT SLC44A5 ACHE CHPT1 SLC44A3 SLC44A4 LPIN1 SLC44A1 LPIN2 SLC44A2 LPIN3 LPCAT1 PCTP PCYT1B PCYT1A MFSD2A CSNK2A1 STARD7 CSNK2A2 PHOSPHO1 CSNK2B LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival GNAT3 GNAZ CD3G FCGR3A SYK FGR HCK ADORA2B GNAI3 FYN FCGR1A FCGR2A PLCG2 AHCYL1 PLCG1 GNAI1 GNAI2 PRKX PRKACA CALM1 IL6 IL10 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 GNG10 IGHV3-33 PRKAR2B V2-15 IGKV1D-39 V2-19 IGKV1D-33 GNG12 GNG11 IGKV2D-28 GNG13 IGKV4-1 IGHV7-81 GNB2 ITPR1 GNB1 V1-11 ITPR2 IGKV2D-30 V1-16 GNB4 V1-13 ITPR3 GNB3 IGHV4-59 IGHV1-69 GNB5 GNGT1 IGLV2-11 IGLV1-40 IGLV1-47 GNGT2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 GGT1 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 DPEP2 IGHV3-13 DPEP1 CD163 IGKV1D-16 PLK2 IGLV7-43 IGKV1D-12 RHBDF2 MYH9 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 GNG3 IGHV4-39 IGKV2-29 IGKV2-28 GNG2 IGLC3 GNG5 IGLC1 GNG4 IGLC2 GNG7 V1-9 V5-4 GNG8 V1-7 GGT5 V5-1 V1-5 V1-3 IGKV3D-20 ADAM17 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAPK14 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAR2A FURIN GNAS YES1 IGHG3 IGHG4 CYSLTR1 IGHG1 CYSLTR2 IGHG2 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta EP300 IFNA21 APP MAVS ATG12 RNF125 NFKB2 ATG5 NFKBIA NLRX1 OTUD5 AGER PIN1 HSP90AB1 S100A12 IFNA5 NFKBIB IFNA4 HMGB1 IFNA7 NKIRAS1 CHUK IFNA6 NKIRAS2 UBA7 IFNA1 IFNA2 IRF3 UBE2L6 IFNA8 TRAF3 ISG15 TRIM4 TRAF6 CREBBP IFIH1 IRF7 HERC5 IKBKE IKBKB NLRC5 TOMM70 TRIM25 MAP3K1 IKBKG S100B SAA1 RIGI PCBP2 RNF216 SIKE1 UBE2D1 RELA RNF135 HSP90AA1 UBE2K CASP10 NFKB1 IFNB1 TRAF2 TNFAIP3 CASP8 RIPK1 FADD UBA52 UBE2D2 TBK1 CYLD IFNA14 IFNA16 IFNA17 UBB DHX58 UBC ITCH RPS27A UBE2D3 TAX1BP1 IFNA10 TANK TKFC G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 CDC25A PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MDM2 MDM4 CHEK2 CHEK1 COP1 ZNF385A TP53 PCBP4 PLK3 ATM GSK3B PHF20 BTRC CDKN1A MAPK14 SKP1 MAPK11 FBXW11 CDKN2A CDKN1B NEK11 CSNK1E RBX1 UBA52 CCNE2 CCNE1 CUL1 PSMD12 CSNK1A1 PSMD11 UBB PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade GNB1 PDE6B PDE6A PDE6G CNGA1 SLC24A1 CNGB1 SAG GNAT1 GNGT1 RHO P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 MDM2 MDM4 CHEK2 COP1 ZNF385A TP53 PCBP4 ATM PHF20 CDKN1A CDKN2A CDKN1B UBA52 CCNE2 CCNE1 PSMD12 PSMD11 UBB PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNA14 GNB1 PLA2G4A GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 P2RY1 GNA11 GNGT1 GNG8 MAPK14 GNGT2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol HSD3B7 CYP39A1 AKR1D1 CYP27A1 ABCD3 AKR1C1 AKR1C3 AKR1C2 AKR1C4 AMACR SLC27A2 SLC27A5 CYP46A1 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy PRKAB2 PLIN3 PRKAA2 PRKAB1 HSPA8 PRKAG1 PRKAG2 PRKAG3 PLIN2 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS CSPG5 DCN NCAN BGN VCAN CHSY1 BCAN GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation GNAT3 ARHGEF9 GNAI3 KCNJ2 KCNJ3 GABRA2 GABRQ KCNJ4 GNG3 GABRA1 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 GNG4 KCNJ10 GNG7 GABRA6 GABRA5 GNG8 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GNAI1 GNAI2 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GABRG3 GABRG2 GNG10 GNG12 GNAL GNG11 GNG13 GNB2 GABRB3 GABRB2 GNB1 GABRB1 GNB4 GNB3 GNB5 GABRR3 GNGT1 GABRR2 GABRR1 NPTN GNGT2 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKBKE UBB TICAM2 UBC LY96 RPS27A PTPN11 TICAM1 CD14 TLR4 UBA52 TANK TBK1 OPTN IRF3 TRAF3 IRF7 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription HEY2 EP300 SNW1 MAMLD1 HDAC4 HIF1A HEYL MYC RBX1 TBL1XR1 NCOR2 KAT2B KAT2A UBA52 NCOR1 HDAC8 TLE4 CREBBP CUL1 TLE2 TLE1 HDAC2 HDAC11 TBL1X HDAC3 UBB NOTCH1 HDAC1 MAML2 UBC CDK8 MAML1 RBPJ HDAC5 RPS27A HES5 NBEA HDAC9 HDAC6 HDAC7 MAML3 HES1 CCNC SKP1 HDAC10 HEY1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes FANCC ERCC3 ERCC2 MDC1 CCNK ATF2 CCNT2 CCNT1 CHEK1 SUPT16H GTF2F1 GTF2F2 TP53 SUPT4H1 CDK7 MNAT1 ATM CDK12 ELOA2 CDK13 ATR SUPT5H CDK9 BRCA1 JUN ELL ELOA NELFB ELOB NELFCD NELFA ELOC NELFE FOS DDB2 RAD51D PMS2 MLH1 CTDP1 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J GTF2H1 GTF2H2 GTF2H3 MSH2 GTF2H4 FANCD2 POLR2E GTF2H5 POLR2F POLR2H CCNH SSRP1 POLR2K POLR2L FANCI TCEA1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors CALM1 DLG4 GRIK5 GRIK3 GRIK4 NCALD DLG1 GRIK1 GRIK2 DLG3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF2S3 RPS15A EIF2S2 EIF2S1 RPS3 RPS2 RPS15 RPS14 FAU RPS17 RPS16 RPS19 RPS18 RPS9 RPS7 RPS8 RPS11 RPS5 RPS10 RPS13 RPS6 RPS12 RPSA RPS27A RPS4Y2 RPS4Y1 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer APC PPP2R1B TCF7L2 PPP2R5E FZD5 FZD4 FZD6 FZD8 CTBP2 CTBP1 CTNNB1 PORCN KREMEN1 KREMEN2 DKK1 DKK2 DKK4 LRP5 LRP6 CSNK1A1 TNKS TNKS2 PPP2R1A GSK3B AMER1 RNF43 AXIN1 PPP2R5B PPP2R5A WNT3A PPP2R5D PPP2R5C PPP2CA PPP2CB G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels KCNJ2 KCNJ3 KCNJ4 GNG3 GABBR2 KCNJ5 GNG2 KCNJ6 GNG5 GABBR1 GNG4 KCNJ10 GNG7 GNG8 KCNJ12 KCNJ9 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 PSMA5 SEM1 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 CKS1B SKP2 CCND1 CDKN1A SKP1 CDKN1B UBA52 CCNE2 CCNE1 CUL1 PSMD12 PSMD11 UBB PTK6 CDK4 PSMD14 CDK2 CCNA2 PSMD13 CCNA1 UBC PSMA7 PSMB6 RPS27A PSMD8 PSMB7 PSMB4 PSMD6 PSMB5 PSMD7 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB30 RAB36 RAB2A RAB3D RAB44 RAB37 RAB32 RAB4B RAB31 RAB5B RAB22A RAB35 RAB40A RAB24 RAB40B RAB40C RAB3B RABGGTB RAB3C RABGGTA RAB38 RAB42 RAB2B RAB34 RAB9A PTP4A2 RAB20 RAB4A RAB25 RAB9B RAB26 RAB23 RAB29 RAB6B RAB15 RAB19 RAB17 RAB5A CHM RAB8A RAB6A RAB39A RAB5C RAB27A RAB7A RAB39B RAB27B RAB8B RAB43 RAB33A RAB33B RAB7B RAB1A RAB1B RAB21 RAB14 CHML RAB11B RAB11A RAB10 RAB12 RAB13 RAB18 RAB41 RAB3A COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade CFD C3 GZMM CFB CLU PROS1 CD81 CPB2 CFH MBL2 C5AR2 CD19 C5AR1 CFI C2 C5 C6 C7 C9 C8B C8A F2 C8G CR2 COLEC11 CD46 C1QB C1R CPN2 SERPING1 CPN1 CD59 CD55 CFHR2 CFHR1 CFHR4 CFHR3 C3AR1 CFHR5 C1QC C1S IGHV3-23 IGLV IGLV2-8 IGKV1-16 C4A IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 VTN IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 C4B_2 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 FCN1 V5-4 FCN2 V1-7 FCN3 V5-1 V1-5 CRP V1-3 COLEC10 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CR1 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 ELANE IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1QA C4BPA C4BPB MASP1 IGHG3 IGHG4 IGHG1 IGHG2 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants APC PPP2R1B PPP2R5E CSNK1A1 PPP2R1A GSK3B AMER1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2CA PPP2CB DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP4A22 CYP4B1 CYP4F11 CYP2D6 CYP2U1 CYP4F22 CYP2W1 CYP4F2 CYP4A11 CYP4F3 CYP2S1 CYP3A43 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A PABPC1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS27L EIF2S3 EIF4A2 EIF4A1 RPS15A EIF2S2 EIF4G1 EIF2S1 RPS3 RPS2 RPS15 RPS14 EIF4E FAU EIF4B RPS17 RPS16 RPS19 RPS18 RPS9 RPS7 RPS8 RPS11 RPS5 RPS10 RPS13 RPS6 RPS12 RPSA RPS27A RPS4Y2 RPS4Y1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells AKT1 NEUROD1 NKX6-1 NKX2-2 PDX1 PAX6 HNF1A INS MAFA RFX6 SLC2A2 IAPP FOXA3 FOXA2 FOXO1 HNF4G GCK AKT2 AKT3 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease FGFR3 GAB1 NRAS PIK3R1 PLCG1 FRS2 PIK3CA FGF1 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 HRAS FGF2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins CCDC88C DVL1 DVL2 DVL3 CXXC4 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription CBFB RUNX3 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis H2AC14 SUN2 H2BC12L FKBP6 H2AC8 H2AC6 H2AC7 UBE2I ACD TINF2 TERF1 TERF2 POT1 TERF2IP H4C9 H2AC20 H2AX ATR SYCP2 SYCP1 SYNE2 SYNE1 SUN1 BRCA1 H2BC26 TEX12 SMC1B H2BC21 SYCE3 SYCE2 SYCE1 HSPA2 REC8 LMNB1 STAG3 SYCP3 SMC3 H2BC17 RAD21 H2BC12 H2BC13 STAG1 H2BC14 STAG2 H2BC15 SMC1A H2AJ H2BC11 H2BC9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC19 H2AB1 H2AZ2 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity GJA1 TJP1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ NRAS PDPK1 HRAS PRKCZ MAPK1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 MSH2 MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 PLCB3 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 PLCB1 PLCB2 GNGT2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding CXCL6 CXCL9 GLP1R CXCL8 CXCL1 CXCL13 CXCL3 CXCL2 CX3CL1 CXCL5 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CXCR1 CCL5 CCR6 CXCR3 CCL4 CXCR2 CCL2 CCL1 CCR2 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR3 ACKR2 CCL28 CCL27 LHCGR TSHR FSHR GPHA2 GPHB5 OPN1LW PDYN DRD1 DRD2 DRD3 DRD4 DRD5 CX3CR1 AVPR1B ADORA2A AVPR1A ADORA3 ADORA1 AVP S1PR1 SST SMO PTCH1 GNAS IHH C3 OPN1MW C3AR1 CCR5 CXCR4 TAS2R20 PF4 GCGR TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R40 TAS2R41 TAS2R43 GABBR2 TAS2R46 GABBR1 TAS2R30 TAS2R31 TAS2R38 TAS2R39 IAPP CRH MCHR1 TAS2R50 NPY SSTR3 WNT11 RHO WNT4 WNT9B OPRM1 RAMP2 OPRK1 MC4R EDNRB EDN1 EDN3 ADM MC3R MC1R MC5R NPFFR2 NPFFR1 CALCRL NPFF QRFPR HCRT QRFP HCRTR2 HCRTR1 F2R F2 TAS2R7 TAS2R8 KNG1 HCAR2 HCAR3 HCAR1 GRM4 TAS2R1 GCG TAS2R3 TAS2R5 TAS2R4 CXCL12 AGT CHRM3 TAS1R2 OXTR TAS1R1 TAS1R3 GRPR EDNRA PROK2 PROK1 UTS2R TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 NTSR1 NTSR2 GPR17 NMB XCR1 NMBR ADCYAP1 LPAR5 ADCYAP1R1 LPAR6 NMS NMU GNRH2 GNRH1 PSAP MLN BRS3 GPRC6A GPR132 ADRA2B CCKAR GNRHR FFAR4 FFAR3 FFAR2 GPR39 ANXA1 EDN2 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 ADRA2C GPR143 ADRA2A MT-RNR2 F2RL1 F2RL2 F2RL3 CHRM1 GPR68 GPR65 PMCH CHRM5 GHSR CASR LTB4R2 UTS2 NTS MCHR2 HRH1 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR HTR2B HTR2C OXT HTR2A TRH GRM1 LTB4R GRM5 BDKRB2 BDKRB1 GNRHR2 XCL2 XCL1 CGA P2RY6 P2RY2 P2RY1 CCK KISS1 CHRM2 CHRM4 ADRB1 GIP ADRB2 HTR4 HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A HTR1B TAAR5 TAAR2 HTR5A TAAR1 ADRB3 CYSLTR1 SCT CYSLTR2 RXFP4 MRGPRD FFAR1 FZD10 RXFP1 RXFP2 RXFP3 CRHBP CMKLR1 ADORA2B AGTR2 FPR1 FPR3 GHRHR GALR3 OPN1SW GALR2 GALR1 NPBWR1 NPBWR2 WNT10B WNT10A FZD9 GPR183 PNOC GPR18 C5AR2 C5AR1 C5 PTH1R UCN3 UCN2 GPR37 GPR35 GPR31 PTH2R RGR PLPPR1 PLPPR2 SAA1 PLPPR3 PLPPR4 PLPPR5 CD55 WNT8A WNT8B P2RY12 P2RY13 WNT7B P2RY14 GPR55 SCTR ADRA1D WNT7A ADRA1B ADM2 ADRA1A MTNR1A TBXA2R MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 CALCA INSL5 PTH2 P2RY4 SHH APLN VIPR1 VIPR2 RRH OXER1 PTGDR GPR37L1 TAS2R19 KEL TAS2R42 GIPR TAS2R45 CRHR1 NLN PENK PPY TAS2R60 PTGDR2 OXGR1 GPBAR1 GAL UCN PTGER4 OPRD1 NPB TSHB RAMP3 PTH FSHB PTGER2 PTGER3 NPW PRLH MAS1 XK GNG10 GHRH MC2R RAMP1 NPY2R GNG12 GNG11 GNG13 NPY1R APLNR GNB2 CALCB SUCNR1 GNB1 WNT6 CALCR GNB4 GNB3 WNT2 WNT3 GNB5 OPN3 PTCH2 OPN5 GNGT1 PYY WNT5A GNGT2 TAS2R9 WNT2B ADGRE1 WNT1 GRM3 FZD1 HEBP1 POMC FZD3 ADGRE2 FZD2 GRM2 FZD5 ADGRE5 FZD4 GRM7 FZD7 GRM6 FZD6 APP ADGRE3 FZD8 GPER1 GRM8 PTGIR NPY5R GLP2R SSTR1 LHB WNT16 GNG3 SSTR2 SSTR4 SSTR5 GNG2 CORT GNG5 GNG4 NPY4R GNG7 OPRL1 PTHLH GNG8 CNR2 CNR1 S1PR3 S1PR2 S1PR5 S1PR4 ACKR1 VIP AVPR2 CCL3 WNT3A WNT9A DHH HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis GPC1 EXT2 GPC3 HS3ST3A1 GPC2 GPC5 HS2ST1 GPC4 GPC6 SDC1 SLC35D2 EXTL2 AGRN EXTL3 HSPG2 HS3ST5 HS3ST6 HS3ST4 NDST2 HS3ST1 NDST1 HS3ST2 NDST4 NDST3 HS3ST3B1 SDC4 HS6ST1 HS6ST2 SDC2 HS6ST3 SDC3 GLCE EXT1 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation LEMD2 SIRT2 CCNB2 CCNB1 LBR EMD LMNB1 LEMD3 ANKLE2 PPP2R2A PPP2R1A BANF1 KPNB1 CDK1 PPP2CA VRK1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking WNT1 WNT9A WNT10B PORCN WNT10A WNT16 VPS29 VPS35 WLS VPS26A WNT11 TMED5 WNT8A WNT4 WNT8B WNT7B SNX3 WNT6 WNT9B WNT7A WNT2 WNT3 WNT5B WNT3A WNT5A WNT2B ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS NTF3 NRAS SOS1 HRAS NTRK3 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection VAV2 CD3G FCGR3A SYK FGR HCK FYN NCKAP1L WAS CDC42 ARPC1B ARPC1A MYO9B ACTG1 ABI2 WASL ABI1 IGHV3-23 NCKIPSD IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ARPC4 IGLV7-43 ARPC5 IGKV1D-12 MYH9 IGLV1-51 IGLV2-23 ARPC2 IGKV3-20 ARPC3 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 BRK1 V1-7 V5-1 ABL1 V1-5 V1-3 IGKV3D-20 NCK1 V5-6 ACTR3 IGLV3-19 IGKV2-30 ACTR2 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MYO5A IGKV1-33 MYH2 V4-6 MYO10 IGHV3-53 V4-2 MYO1C IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 WASF1 WASF2 WASF3 BAIAP2 RAC1 MAPK1 MAPK3 ELMO1 BTK ELMO2 DOCK1 CRK PTK2 CYFIP2 CYFIP1 NCKAP1 WIPF1 WIPF2 WIPF3 YES1 VAV3 IGHG3 IGHG4 IGHG1 ACTB IGHG2 VAV1 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b MPI ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis CD3G PIK3R2 FCGR3A SYK PIK3CB PIK3R1 FCGR1A FCGR2A PLCG2 PIK3CA AHCYL1 PLCG1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 ITPR1 V1-11 ITPR2 IGKV2D-30 V1-16 V1-13 ITPR3 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 PRKCD IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 PRKCE IGKC PLPP5 IGKV1-39 PLPP4 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PLD4 PLA2G6 PLD1 PLD3 PLD2 IGHG3 IGHG4 IGHG1 IGHG2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDKN2A CDK4 CDK6 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F2 PROC BGLAP F7 PROS1 GGCX FURIN F9 GAS6 PROZ F10 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones DUOXA1 DUOXA2 IYD TPH2 TPH1 TXNDC11 CAV1 DBH TPO AANAT TH ASMT CGA PNMT DUOX1 SLC5A5 DDC DIO1 DUOX2 TSHB DIO2 DIO3 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases PRDX2 GOLGA2 CDC25A PRDX1 APP CDC25B YWHAE LMNB1 CDK5 FASLG CAPNS1 CAPNS2 CDC25C CAPN2 CAPN1 CAST FOXO3 SOD2 CDK5R1 JUN BCL2L11 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 NRAS FGF1 FGF4 FGF22 FGF3 FGF9 FGF10 FGF20 SOS1 FGF23 HRAS FGF6 FGF2 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis H2AC14 EP300 PBX1 H2BC12L CNOT6 H2AC8 H2AC6 H2AC7 KMT2D KMT2C PAXIP1 RXRA CNOT9 RARA HOXA2 CREBBP H4C9 YY1 PAX6 H2AC20 EZH2 H2AX DPY30 ASH2L PAGR1 H2BC26 JUN RARG H2BC21 H3-3B H3C8 WDR5 NCOA6 EGR2 NCOA3 KDM6A RARB EED HOXA3 HOXA1 H2BC17 PKNOX1 HOXA4 H2BC12 PIAS2 H2BC13 H2BC14 HOXB3 H2BC15 HOXB2 HOXB1 H2AJ HOXD1 MEIS1 AJUBA MAFB NCOR1 H2BC11 HOXC4 HOXD4 HOXD3 ZNF335 PCGF2 H3C15 POLR2A HDAC3 POLR2B CTCF POLR2C POLR2D SUZ12 H2BC9 H2BC8 POLR2G H2BC5 POLR2I H2BC3 RBBP4 POLR2J H2BC1 RBBP5 POLR2E POLR2F POLR2H RBBP7 H2AC19 POLR2K POLR2L H2AB1 HOXB4 H2AZ2 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing OGG1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade ATF1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAP3K8 MAP2K3 MEF2A MAP2K4 UBE2N MEF2C TAB3 MAPKAPK3 TAB2 TAB1 MAPK9 MAPK8 ALPK1 MAP2K7 S100A1 NLRX1 MAPK10 AGER TNIP2 S100A12 N4BP1 MYD88 NFKBIB HMGB1 NKIRAS1 NKIRAS2 IKBIP IRAK4 FGB FGA PELI1 LRRC14 FGG TRAF6 USP14 PELI3 PELI2 NLRC5 USP18 TIFA MAP3K1 S100B SAA1 NOD1 NOD2 TLR1 PPP2R1A S100A9 S100A8 TLR2 BTRC RELA SKP1 CD36 FBXW11 NFKB1 LY96 TRAF2 CASP8 CD14 UBA52 TLR4 CUL1 UBB UBC RPS27A ECSIT SOCS1 DUSP4 DUSP3 VRK3 APP DUSP6 DUSP7 NFKB2 NFKBIA ATF2 SIGIRR IRAK3 CHUK IKBKB TP53 IKBKG RIPK2 MAPKAPK2 TIRAP PPP2R5D MAPK14 JUN PPP2CA MAPK11 PPP2CB PPP2R1B MAPK7 TLR6 FOS MAP2K1 MAPK1 MAPK3 BTK MAP3K7 UBE2V1 MAP2K6 IRAK1 IRAK2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling PIK3R2 INPPL1 PIK3CB IL5 PIK3R1 JAK2 IL2RG JAK3 IL2RA IL2RB PIK3CA IL2 PTPN6 IL3 IL5RA PIK3CD SOS1 GAB2 CSF2RB INPP5D JAK1 SHC1 CSF2RA CSF2 IL3RA PIK3R3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript NUP62 NUP37 NDC1 SEC13 NCBP1 NUP133 NCBP2 NUP107 NUP188 EIF4E NUP50 WDR33 NUP54 NUP210 CPSF4 CPSF1 NUP93 CPSF3 CPSF2 NUP205 POM121 NUP214 NXF1 NUP42 AAAS NUP160 ALYREF POM121C NUP85 NUP43 TPR NUP88 FIP1L1 SYMPK RAE1 RANBP2 NUP155 NUP153 NUP35 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions LAMA5 ITGA1 LAMC3 LAMA3 ITGA2 NID1 LAMB3 ITGA3 LAMB1 ITGA7 LAMA2 LAMA4 LAMB2 ITGB1 LAMA1 COL18A1 LAMC2 LAMC1 NID2 ITGA6 ITGAV HSPG2 ITGB4