SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors 7341 367 7421 2908 5914 10401 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis 137964 8895 9489 23760 1120 1460 80339 162466 10809 9362 1457 84649 55500 54675 56994 114971 55224 51365 11343 11145 81490 8904 56261 57153 3030 79143 171586 23175 150763 254531 50487 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling 1956 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition 55835 7846 8636 10540 5108 84131 4957 9662 8655 7840 1781 22995 22897 7283 891 1778 54930 84962 1453 8945 11190 9133 23354 80254 121441 55755 10806 10121 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix 5340 6650 176 1215 1511 80781 3818 836 4326 4327 6868 10753 50859 9510 9313 4321 164656 7092 1303 23473 4312 5644 11132 5645 649 4316 80274 1308 4318 1306 4319 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression 23054 6996 6319 60481 10025 133522 113835 7343 5440 5441 23067 3021 3065 9440 79595 7581 63924 91272 10514 2966 892 3018 84649 85236 2167 3014 54934 11168 9439 121536 11343 54815 54737 2967 22822 30827 26147 100170841 79101 51230 23175 79862 7700 10445 84962 9862 6871 285676 1020 8370 2071 55689 26993 51003 2146 197320 8968 5931 404672 8347 4221 8348 22880 3054 25799 79685 84911 8819 123 29115 1024 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides 6278 5068 6037 1511 503618 6280 475 80341 84659 3347 114770 140881 1113 3346 51297 140850 417 5657 51248 5645 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis 5688 5689 2043 5701 10683 5714 343930 5717 5718 134701 1499 5687 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism 686 8884 5091 51248 32 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport 57153 345274 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements 5688 5689 5701 5714 5393 8741 11340 26986 22894 23404 54512 1432 167227 51013 207 7538 118460 5717 5718 5687 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state 51098 5688 55764 5689 5567 5568 5701 9978 5714 8945 374654 5573 9742 5717 5576 5718 83737 6608 80199 5687 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 2218 10559 79147 113829 729920 120071 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 8968 5931 8347 3018 8348 85236 3014 8370 3021 3065 54815 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs 5688 5689 5701 9978 5714 161742 200734 64926 153090 4763 399473 10156 5717 5718 5687 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation 1675 629 HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle 6749 93343 6883 6882 6884 7251 25978 51271 5440 79643 5441 1104 51652 79902 6877 6879 4836 2966 11168 2967 2071 404672 8178 6396 6873 57122 4927 2962 54457 23165 5436 55746 7518 10015 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 10675 3074 8372 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes 23586 7318 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling 160 161 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade 5525 23401 5526 5527 5528 5529 1499 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib 11140 55914 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 6687 5245 9512 11331 10367 90550 55486 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development 182 3172 2668 3207 10736 2138 3237 3214 3203 3400 3975 7849 1499 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK 5295 238 10818 3667 4192 3065 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat 6749 2966 404672 8178 5440 2962 5441 2071 5436 2967 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs 27327 1009 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF 6046 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins 1558 1565 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants 11140 55914 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7341 79047 284252 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX 64682 11065 10393 51343 27327 246184 51529 1499 1029 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection 23118 11218 23193 201595 3105 7341 10000 25978 746 51114 79643 6732 5648 51652 1603 79902 23586 6230 6232 6231 5781 6234 64398 6235 3441 2197 7284 3439 3716 140032 51284 26276 6227 51125 65082 6229 207 8767 4249 7297 221914 6482 9672 6441 6484 6487 30849 7335 64601 6480 2239 3449 29110 256435 196527 3443 208 2719 6636 6635 6637 3605 84061 112744 10392 11282 55741 6396 11320 6205 57122 6207 4927 55823 51304 3654 23165 6209 8487 55746 6185 23479 6184 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome 6749 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 8178 6873 2962 54457 5436 2967 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels 6543 6546 490 491 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors 1141 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 7846 9630 1460 22803 63971 26985 2782 7280 1457 5082 79861 2785 59345 898 2783 6468 8877 10574 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 113835 79862 7700 285676 8370 3021 3065 7581 197320 8968 5931 8347 3018 8348 85236 3014 25799 84911 54815 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing 7027 1871 7029 10046 4854 10402 3725 1999 8370 3021 8968 8347 3018 8348 27327 85236 3014 6484 6487 22938 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 6421 2908 2034 387 1956 1796 1398 1793 55620 5753 867 207 898 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) 7341 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism 5168 79717 55229 2194 8884 51248 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion 2181 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript 6396 9785 199746 57122 4927 7919 9984 79228 23165 79902 84321 55746 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 79054 7225 54795 59341 55503 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation 7099 7186 355 8797 8737 23643 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation 5688 23118 7335 5689 5701 5714 7322 8945 997 5717 5718 5687 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 1020 627 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization 1956 5753 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 6396 57122 4927 2645 23165 79902 55746 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 84515 8318 9837 51659 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 7046 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation 5906 5594 5604 10818 5605 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling 10818 5781 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly 341 338 4547 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase 64682 5688 11065 5689 10393 51343 5701 5714 891 8945 8900 5717 5718 246184 51529 5687 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism 25979 5210 6783 5332 91942 5333 8720 3155 10249 253782 3028 89869 79944 6898 5445 4357 427 5446 549 5447 29090 5207 5208 5209 5464 6555 10690 339983 3161 3038 435 4125 5214 316 5336 6548 4128 6309 5471 3290 4144 5476 80704 23530 389396 25830 3295 23533 51171 51293 51295 443 57834 51179 79602 205 4257 5105 4259 192286 6573 64132 9962 6697 9963 55300 10678 56997 55788 335 336 337 5236 9956 8867 7416 54579 6341 51070 23632 51071 100 10449 344 345 348 9967 10201 326625 5264 4056 11185 79094 64834 337876 231 594 116255 84320 83594 9615 53947 51647 150274 6120 126282 6240 9997 6124 29956 23057 29958 127 4074 6130 125061 9524 5287 4199 28 131669 116228 29920 4190 28958 4191 51302 6128 51422 8789 11046 6129 5294 6141 9651 347411 6146 9415 8566 130589 262 384 1800 51552 84693 347527 7363 9420 47 11261 48 6156 10295 6159 7368 26873 64757 150 6391 271 272 6390 51447 161247 6168 7498 9435 6169 6160 221357 7371 51218 7385 9200 7386 7389 65985 64777 6170 178 25880 51102 51103 8228 1836 347735 9331 9453 64781 23474 23597 3906 54988 51117 1728 10048 7166 9348 9107 191 90161 9583 57226 1733 2821 57107 26275 29785 26035 7296 641371 134526 7298 112950 22928 9110 388931 2952 10825 10948 9108 10941 133688 440957 340075 9481 57128 26251 346606 3930 1638 117283 9256 9255 341392 55190 9495 728568 3705 3707 27232 27233 1528 7086 2744 60678 2864 58478 50512 102157402 2628 2747 92014 130367 619189 377841 9390 79048 2752 1428 96764 373156 2771 79071 94101 4947 4707 4708 1312 2643 574537 51504 4701 3992 2531 51750 4830 4710 4833 4712 3745 2539 3628 4714 1208 2538 7421 137964 8895 9489 23760 1120 1460 80339 162466 10809 9362 1457 84649 55500 54675 56994 114971 55224 51365 11343 11145 81490 8904 56261 57153 3030 79143 171586 23175 150763 254531 50487 176 5644 9862 51003 22880 123 1024 23054 6319 60481 10025 133522 9440 63924 892 2167 9439 51248 5717 5718 5687 5688 5689 5701 5714 686 8884 5091 32 207 5573 5576 5567 5568 6396 57122 4927 23165 55746 79902 4836 8372 10675 3074 5528 5295 1558 1565 6230 6232 6231 6234 6235 2197 140032 6227 6229 221914 6482 9672 6484 6487 30849 2239 2719 6205 6207 6209 9630 2782 2785 59345 2783 8877 10402 5168 79717 55229 2194 2181 2645 5906 338 23729 81849 1581 23600 22874 22876 2548 51084 4728 1337 80765 2542 3630 3631 4720 3633 4722 4967 1339 1350 51091 2678 2799 55331 1468 79642 1345 51099 1585 1584 55217 5825 22977 65263 728294 378884 3420 10998 3417 55586 2327 4508 4509 57761 55347 83930 27068 55349 5834 57407 5836 5837 3418 66002 3790 4520 5730 1374 144193 2583 204219 169355 152926 4519 10768 124872 57412 4758 1384 2350 10855 27165 3313 2101 4522 6948 548596 6947 4540 4541 80306 2597 5501 4534 4538 5507 5641 6609 83733 10955 1158 10715 1036 28234 6723 617 4548 161823 4682 376497 2023 57571 79581 613227 145482 26063 81544 55276 10606 27158 501 57214 10728 10840 26061 10720 5660 5783 4696 2274 154807 51241 873 2026 51000 875 79814 51004 10131 55967 516 759 5538 11224 55969 162417 10380 25994 3376 25874 339896 760 761 54884 765 766 151531 405 166929 284161 113235 5444 3145 2052 2172 644096 2171 2170 8824 54659 51268 6888 79837 89874 8707 9917 9915 10478 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds 54988 11046 6783 55347 373156 191 10249 10720 1312 54579 574537 51504 7363 2952 57412 26873 79094 10941 133688 10380 4144 221357 341392 389396 25830 2678 27233 54659 50512 4548 4257 4259 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis 7166 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes 5027 834 29108 10910 9447 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model 9481 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects 64682 11065 10393 51343 246184 51529 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation 3376 8565 6897 7407 2617 2193 5464 9255 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 5906 3082 85440 2549 1398 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 374 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA 5781 151888 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 1937 6130 6170 6205 6207 6209 6128 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation 2252 27006 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border 5460 83439 7545 4602 1499 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) 7249 10000 207 208 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism 79048 2752 1428 10249 4947 3028 6898 4357 549 339983 435 443 5717 5718 5687 5688 5689 5701 5714 11185 594 4967 6124 51091 29958 1468 6130 125061 55217 131669 65263 29920 6128 6129 6141 55349 6146 57407 262 384 144193 169355 152926 6156 10295 6159 1384 27165 57153 548596 6168 6169 6160 10955 6170 1158 1036 6723 4548 347735 23474 57571 1728 6230 7166 6232 6231 501 191 6234 6235 1733 2197 26275 140032 7296 6227 875 79814 6229 22928 11224 162417 3376 339896 1638 9255 27232 2744 60678 6205 58478 6207 51268 2628 89874 2747 6209 619189 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production 113220 3833 11004 8165 64145 161882 23414 10749 10362 51317 829 3441 3021 9927 3065 3439 5573 5576 5567 5568 3449 1020 3443 85440 1793 3705 8968 4602 23046 55582 23764 23028 64837 10019 81930 2623 29127 998 55669 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion 27159 278 1208 8513 8544 2980 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 8894 1968 8890 1967 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation 26276 51606 11151 7879 4843 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling 3313 6627 6648 829 3716 7297 3181 6888 3595 3594 759 3593 3592 1072 998 27250 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 571 9978 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 23428 9056 10991 23657 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 23054 6319 60481 10025 133522 23067 3021 9440 63924 91272 892 3018 84649 85236 2167 3014 54934 11168 9439 11343 22822 30827 51230 9862 23175 6871 10445 1020 8370 55689 26993 51003 8968 8347 84962 4221 8348 3054 123 1024 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors 9963 9390 55788 686 8884 5091 10840 32 8566 326625 5644 2350 316 4522 83594 6948 6947 80704 113235 23057 5168 51293 79717 1528 55229 2194 4548 51248 6573 92014 9962 79581 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated 5594 5528 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response 6868 1432 4627 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 10000 5440 5441 3065 2966 2539 898 54815 2967 7027 834 7029 51230 3725 7249 355 8797 1432 207 8900 1337 5300 79370 57060 1339 117584 9997 1350 7832 84289 10650 5932 57472 55215 1345 6119 6118 9125 8178 2176 6873 28956 4193 144455 204851 2962 29883 54457 4869 5436 64065 64223 7874 8445 6749 51422 545 5325 6883 25946 6882 7486 6884 5982 5983 133746 79733 27166 55367 5457 835 6877 9156 6879 5111 64769 53632 1460 5984 5985 8738 91875 5883 1457 54971 5875 83695 5371 580 5527 112858 3622 79109 133383 51755 27165 891 27327 613227 55835 2821 7296 1020 208 2071 5931 404672 2744 79837 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism 1158 548596 2628 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes 6883 23067 3065 64769 79595 3018 85236 3014 54934 121536 54815 22992 23522 8295 23326 23569 117143 10856 51230 6944 8607 8464 10445 84193 55693 84159 10902 79723 55818 339287 54496 51780 54859 8242 55193 25855 353238 221656 23028 23030 51111 80854 10765 8518 10362 51317 6871 8370 55689 84289 2146 8968 5931 8347 8348 3054 79685 8819 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 64682 11065 10393 246184 51529 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules 9153 23568 11046 51000 10559 8884 51248 376497 55315 28965 222962 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle 8502 8301 7126 390 29766 9352 22852 57216 1832 10505 253980 5783 23592 3895 10970 5295 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants 3815 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 6550 389015 6548 6549 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 28964 22865 101059918 58504 81624 80776 116984 55114 708 50508 22836 3021 4771 5585 5586 286205 23002 644150 23129 1536 1535 398 3018 6709 29984 85236 5579 3014 4646 157285 898 4649 57551 2631 144402 10574 9826 4810 83540 5747 9828 22899 5361 8476 5880 10152 2010 85440 29843 387 2491 695 84144 6280 1793 613 70 51466 140735 26050 2802 3071 25936 4162 10160 79180 23028 7919 10163 64837 1445 224 81930 55831 10726 29127 128239 998 1499 11135 55669 8239 54509 5924 11004 87 9927 5594 1432 7879 1072 4627 5300 4722 6396 5825 57122 55746 367 79902 5525 5526 5527 5528 5529 11140 55914 182 5501 8655 1781 5295 10818 1778 4548 8502 8301 7126 6232 390 29766 9352 22852 57216 1832 10505 253980 5783 23592 3895 10970 10093 4296 25909 10097 10096 23048 1063 57580 10811 10810 80243 55843 29941 30849 1730 1058 79019 5930 10254 3930 23616 7454 26049 7170 8370 2040 55971 84317 2316 143872 10788 55852 10144 8968 9367 348235 27 8347 4221 57120 220134 8348 57480 4628 23380 11329 57522 4983 537 51306 221178 DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells 7124 10046 8535 3596 4094 3725 80012 10538 6348 6304 51621 3065 648 10014 7528 5931 4221 3595 54815 22938 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration 48 3417 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine 2673 5973 51005 55577 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling 7186 7132 7124 330 142678 8737 29110 329 81858 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex 8295 8607 8370 3021 3065 83439 8968 8347 4221 3018 8348 85236 8313 3014 1499 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins 363 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome 5688 5689 5567 5568 5701 9978 5714 8945 5717 5718 5687 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 7099 29110 23643 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi 11282 6480 11320 4249 9331 4248 6484 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation 23118 7335 3725 5594 10392 5604 1432 8945 8767 3654 5528 1326 4208 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway 10025 133522 113835 5440 5441 23067 3021 3065 9440 7581 2966 892 3018 85236 5579 3014 9439 54815 2967 51230 79862 7700 5105 5717 5718 1499 8239 5687 5688 5689 5701 8535 5714 4094 80012 648 10014 7528 1432 348 207 4208 30818 83737 728957 168374 5816 29028 155061 117581 9978 4605 5275 121274 29959 79088 54487 84671 9997 4852 284443 6910 7582 100289635 1482 163255 23269 6929 388567 8178 814 815 6873 816 817 818 2962 22869 54457 4089 9534 5436 1493 284309 100131980 51422 283337 6749 22835 10172 6883 7004 6882 7005 6884 1021 84914 3558 57541 147741 2103 90594 90233 6877 8463 6879 1030 51333 26974 65988 79230 25888 339327 26053 353274 57209 286075 181 5527 126068 7703 50943 163081 7712 442319 7711 147949 57474 91120 80110 182 390927 221044 3172 4336 5308 23429 1876 84626 51385 23660 171392 7738 7753 441234 23314 144348 7625 7627 114026 27327 84527 6046 4488 7757 8861 90874 79047 284252 162972 246184 148213 51529 148203 1029 148206 64682 7769 11065 80032 10393 374928 51343 148103 126231 1437 140612 5781 10432 3977 349075 163049 163051 2821 463 163050 654254 84775 7549 7296 112950 3930 208 2744 3654 10000 2539 898 2538 22938 7027 834 7029 10046 4854 3725 83439 4602 7249 2623 355 8797 161882 627 2645 5594 8900 1337 6648 3630 5300 79370 57060 1339 117584 1350 7832 84289 10650 5932 57472 55215 1345 6119 6118 9125 2176 28956 4193 144455 204851 29883 4869 64065 64223 7874 8445 545 5325 25946 7486 5982 7341 5983 367 133746 79733 7421 27166 2908 55367 5914 5457 835 9156 5111 64769 53632 1460 5984 5985 8738 91875 5883 1457 54971 5875 83695 5371 580 112858 3622 79109 133383 51755 27165 2101 1956 891 55193 10765 613227 55835 3815 9862 285676 1020 8370 405 2071 51003 2146 197320 8968 5931 404672 8347 4221 8348 25799 79837 84911 9915 1024 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis 4728 3313 91942 4540 4720 4541 150274 4722 57226 4707 4708 4538 4696 4701 51295 25880 4710 51103 4712 55967 4714 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 23373 7942 1407 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion 54931 9692 60528 3028 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway 2244 2239 196527 2719 3818 6609 5197 2243 2161 5657 221914 2160 5270 9672 2159 2147 2158 2266 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling 9481 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle 6749 93343 6883 6882 6884 7251 25978 51271 5440 79643 5441 1104 51652 79902 6877 6879 4836 2966 2967 2071 404672 8178 6396 6873 57122 4927 2962 54457 23165 5436 55746 10015 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins 7341 10401 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 272 100 161823 271 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase 5567 5568 5573 5576 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins 9037 4582 394263 5199 4854 7058 4585 339366 221981 727897 79875 81794 80070 9510 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication 6129 6230 6232 6141 6231 5440 6234 6146 5441 6235 79902 2197 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6396 6205 57122 6207 4927 2962 23165 6209 5436 55746 6128 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures 197342 79728 7486 51750 580 9156 80198 146956 79008 5932 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 246213 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action 3437 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) 93343 84313 10254 7251 25978 51271 79643 51652 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport 476 1179 479 9311 5350 219931 481 483 486 7809 523 495 496 490 1831 491 10110 10396 10312 50617 6340 94015 6588 57130 9296 23678 148229 53373 6339 55515 6338 40 51248 7225 54795 59341 55503 79054 51606 196527 2040 23200 245972 815 1186 816 1185 817 1184 818 374868 1183 1182 1181 537 133308 1180 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 387 7046 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection 917 5567 5336 5568 2771 4627 2678 1800 6868 1432 2782 10768 2785 59345 5573 2783 5576 2781 10800 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function 611 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 867 5295 5594 10818 5781 2549 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 23118 7099 7335 7186 28512 9097 57162 28511 23643 4615 3725 5594 51284 10392 51295 5604 1432 8945 8767 3654 5528 1326 4208 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation 27006 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 116255 5567 5568 346606 23175 150763 5501 2172 51099 2171 2170 84649 2167 8228 11343 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism 2752 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein 7341 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism 65985 3155 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs 4221 128239 1499 998 10788 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste 6340 255022 6339 6338 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation 11282 6480 11320 4249 9331 6484 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly 891 6396 57122 4927 91754 9133 10783 23165 79902 55746 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A 10000 207 208 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry 2239 221914 2719 9672 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 5594 5747 10000 207 208 1956 374 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism 26035 11046 2239 9348 90161 9956 221914 2719 9672 10855 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis 8301 7164 9026 130340 8546 388552 2495 6272 2647 55330 54885 408 9829 5878 THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis 1733 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 653509 729238 1438 6441 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes 55835 7846 8636 10540 5108 84131 4957 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 27229 23354 114791 80254 85378 121441 55755 10806 10121 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling 5294 2782 10000 207 2785 59345 387 208 695 2783 998 23533 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling 5594 6868 3667 5618 8660 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis 51117 56997 51004 57107 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling 144165 5688 8322 5689 7474 8323 5701 8324 5714 5158 5532 2780 81029 57216 23002 2782 160 161 5579 2785 59345 2783 5880 387 83439 27327 815 5717 5718 1499 5145 5687 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation 4646 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) 7124 6348 3595 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease 594 152926 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants 238 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response 5688 5689 25946 5701 51230 5714 64326 57060 4193 8900 898 5717 5718 5687 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport 51098 140735 55764 112752 28981 9742 8655 79989 255758 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants 5525 5526 5527 5528 5529 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha 23054 57761 96764 10025 133522 335 336 9440 2274 4520 7296 3992 1374 892 112950 9967 1581 9439 2101 9862 80306 405 51003 4199 376497 123 9915 1024 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants 238 ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets 5594 1432 5528 4208 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions 8745 10368 4185 55203 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism 686 5091 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation 7318 6468 8945 5717 5718 246184 51529 5687 64682 5688 11065 5689 10393 5701 51343 5714 7322 997 154881 7320 91694 23608 142678 79654 84961 8924 51444 7319 22888 7332 64320 83737 6049 25831 23014 7335 27252 64718 642 5930 9978 57674 25793 11275 55658 54926 4591 51619 64410 55182 26259 51465 144699 9730 25898 84727 146330 92591 140460 80176 54620 55236 53339 6737 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors 1816 1815 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin 4128 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 22803 63971 26985 898 6468 8877 10574 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion 2782 2771 2785 59345 2783 150 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 6648 7186 8737 3725 708 1020 8370 3021 2146 8968 5931 8347 3018 8348 85236 3014 23649 2801 1687 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism 51422 145482 26063 6319 60481 79071 10728 9415 26061 1800 5445 5730 84693 3992 1374 5446 873 641371 10449 134526 47 5264 4056 23600 1384 5538 64834 84320 3030 9200 2678 3295 5444 9524 2194 57834 51102 2181 51179 22880 1558 376497 23597 10478 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors 10368 160 815 5579 816 4193 4646 817 818 9495 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 3178 54845 5781 5440 5441 2549 2252 27006 867 5295 5594 10818 2962 5436 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 6873 2962 54457 5436 2967 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 5688 5689 2060 5701 54971 5714 4193 5717 5718 1499 5687 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis 917 5747 5336 4651 4644 7454 10152 4627 4771 695 1398 1793 644150 5295 5594 3071 10093 10097 10163 10096 10768 10810 1072 998 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope 8502 5493 643394 25818 353134 43847 353133 1832 353135 353137 353139 199834 353141 353140 353143 353142 643414 142910 5317 643418 3713 64065 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response 5594 22900 708 79792 836 1687 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase 4843 10846 27345 5136 50940 3779 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere 54386 546 5440 5441 8370 3021 8347 3018 8348 85236 3014 5436 7014 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling 5295 3082 2549 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint 64682 11065 10393 11004 6232 80776 79902 25909 5525 5526 5527 1063 5528 57551 5529 83540 1058 79019 2491 5501 8655 1781 140735 348235 1778 25936 6396 220134 57122 81930 10726 55746 246184 51529 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals 8633 1630 5781 PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy 2034 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism 6898 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction 64398 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants 2322 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 6129 6230 6232 6141 6231 7322 6234 6146 6235 2197 140032 6227 6229 6156 6159 11224 6168 84164 6169 6160 6124 6130 6170 6205 6207 6209 6128 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 5688 5689 5701 10000 5714 81847 2444 208 1460 23608 1457 207 5717 5718 80243 5687 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs 28964 10645 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection 4651 4644 2771 1800 644150 1535 2782 2785 10768 79792 59345 2783 10910 2781 10800 917 5027 834 5747 29108 5336 3725 10152 5025 719 695 1398 1793 3071 10163 998 7474 8324 1511 6868 5594 1432 10093 10097 10096 5573 10811 5576 10810 5567 5568 7454 4627 2678 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism 6480 10402 10559 256435 5476 81849 10825 6482 10020 4758 6484 6487 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 3065 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) 7004 6732 8370 3021 23405 8106 100288687 26986 503835 57472 55211 1975 8968 678 284355 9125 8347 1977 3018 8348 85236 3014 29883 10765 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 51422 28964 2771 1141 53632 160 2782 5579 2785 4646 59345 2783 10645 3760 2900 2743 55327 200909 2901 200959 3772 2562 2557 116443 57554 1144 5924 116444 3762 3766 9568 2570 2569 55584 4900 8001 5594 10368 5573 5576 5567 5568 9495 814 815 4193 816 817 818 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development 10046 3630 10000 2645 208 3170 4760 3651 390874 256297 389692 4821 207 22938 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 8968 5931 8347 3018 8348 85236 3014 8370 3021 23649 1687 2146 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium 55835 7846 8636 10540 5108 80776 84131 4957 112752 28981 79989 255758 347240 23265 84100 2847 132320 8766 5311 55212 26123 9742 54806 6608 51098 55764 9662 8655 7840 1781 22995 22897 140735 7283 1778 54930 1453 11190 23354 80254 121441 55755 10806 10121 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5688 5689 5701 6129 6168 9978 6141 5714 7322 6169 6146 6160 6124 25898 6130 6170 6156 6159 5717 22980 5718 11224 5687 6128 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 51293 6948 55788 6947 326625 4548 5644 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members 5914 3065 1030 7046 5594 892 9110 5664 4090 22938 23645 7027 7042 657 91 7029 658 9958 659 51107 11171 9350 268 387 55851 5501 3685 4654 4656 867 6929 408 4221 27327 4089 1024 8239 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 4605 4869 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily 7341 8370 3021 3065 114825 23613 125997 23394 8968 6941 5931 10320 8347 170394 3018 8348 85236 3014 5105 54815 2538 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 1558 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression 5440 10728 5441 3021 3065 7528 3018 85236 3014 3725 8370 8968 4602 8347 9126 27327 10735 8348 2288 23028 8204 23030 2962 7031 5436 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 3030 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling 5295 5781 7010 51378 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors 57472 1975 678 9125 1977 29883 23405 26986 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 891 8900 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 10038 10920 1642 5886 5982 5887 7341 5983 7508 10401 5111 7528 5984 5985 2966 2967 9978 8607 10445 2071 6119 404672 6118 5981 64708 50813 57804 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance 160 338 161 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events 1144 55584 1141 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation 5594 3630 3667 8660 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria 3002 4836 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling 7341 5781 3716 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism 130367 55331 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs 5688 5689 6129 5701 6230 6232 5714 6141 6231 2107 6234 65110 6146 9355 6235 4440 6585 2197 3199 1287 2935 26986 140032 6227 6229 6156 6159 11224 9978 6168 6169 6160 6124 6130 6170 6205 6207 8861 5717 6209 5718 6128 5687 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 23054 6319 60481 10025 133522 3021 9440 63924 892 3018 84649 85236 2167 3014 9439 11343 22822 9862 23175 1020 8370 51003 8968 8347 84962 8348 123 1024 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants 3815 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6230 6232 6231 6234 6235 2197 8662 26986 8663 140032 8894 1975 51386 3646 1968 6227 1978 1977 6205 6229 6207 6209 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing 4913 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events 5567 5332 5568 10645 9630 5594 814 815 816 10768 817 818 5573 5136 5576 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus 51447 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane 30849 55300 3631 9110 4534 22876 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin 2147 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation 4316 1308 4318 1306 80781 1287 3691 9313 1286 1293 7092 871 1303 4016 5479 84695 5339 7837 649 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle 22999 10815 8499 9256 55327 8541 8497 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 814 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) 80267 10206 55741 56886 84447 7844 55757 11236 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation 5460 79923 4089 1499 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling 57761 5294 10000 3065 1460 1457 5525 5371 5526 5527 5528 5529 79109 54815 2322 81847 4615 3725 5880 2444 3082 2549 1956 90865 374 8870 9965 2252 152831 27006 23533 6801 1958 5295 23239 84335 10818 6615 7249 3667 27327 23028 5717 5718 8660 5687 5688 5689 5701 8535 5714 5781 80012 627 648 10014 3815 5594 23608 207 80243 3630 208 2146 5931 28956 4193 3654 79837 64223 7874 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis 834 7186 355 8797 57162 8737 3002 25978 79643 51652 836 330 329 79792 7332 11140 83737 1687 10015 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 5924 9828 22899 445328 2782 2785 59345 387 695 2783 57580 9826 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease 3002 549 4913 5479 435 5336 4128 84447 5476 9965 152831 6801 23533 51293 84335 22872 2305 9076 30011 928 3791 57534 81622 1487 283455 10523 10613 3554 712 388585 57794 55788 127833 335 145226 22808 22943 5236 22827 2261 6993 11221 54518 5551 55733 56949 9900 100 56829 6638 6530 10594 6523 10236 7750 326625 53335 79947 30061 23524 553 115004 10465 11314 594 6575 9843 7301 5002 5119 10313 51639 8896 597 51645 3092 6124 24148 9990 4061 51411 11160 8672 6130 9646 10195 57085 4072 85313 9532 10084 11051 9648 10294 6271 10058 51585 6128 10280 23476 57461 84844 6129 56259 5294 83999 6141 22924 116085 9360 6146 29760 1993 1870 130589 1639 79053 9382 1800 3714 51729 26127 9152 2634 9420 4939 2633 3840 80273 6156 29851 10295 6159 26873 6168 6169 6160 6170 1836 191 26275 7296 112950 2771 1312 2538 10910 5027 834 29108 3082 2549 374 1937 2252 27006 7249 23028 998 10362 51317 51606 11151 7879 4843 3181 6627 6648 9056 4627 5932 6119 6118 4193 4869 64223 545 7486 5982 5983 7341 2908 9156 1460 5984 5985 5883 1457 83695 5371 580 79109 1956 8655 1781 891 1778 25855 8945 55315 176 1511 3818 3815 6868 10093 9510 4296 10097 10096 10811 10810 4318 10254 9862 7454 1020 7170 8370 2071 51003 2146 8968 5931 404672 8347 8348 79685 8819 1024 10025 708 5440 5441 3021 3065 9440 644150 2966 1535 892 3018 85236 3014 11168 57551 9439 54815 2967 5747 5880 10152 695 613 6280 140735 3071 10163 1445 5717 5718 1499 5687 5688 5689 5701 5714 686 5091 10014 26986 2673 1432 142678 207 5573 5576 83737 5567 5568 9978 10559 29959 161742 200734 4763 399473 8178 814 6396 815 6873 816 57122 817 4927 818 2962 54457 23165 4089 5436 55746 7518 10015 6749 93343 6883 6882 6884 1021 7251 25978 51271 79643 1104 51652 79902 6877 6879 4836 10675 3074 23586 7318 160 161 5525 5526 5527 5528 5529 11140 55914 5245 182 5295 238 10818 3667 246184 51529 1029 64682 11065 10393 51343 6230 6232 6231 5781 6234 64398 6235 3441 2197 7284 3439 3716 140032 51284 26276 6227 51125 65082 6229 8767 2243 4249 2161 7297 221914 2160 6482 2159 9672 2147 6441 2158 6484 2266 6487 2244 30849 7335 9037 4582 64601 6480 394263 2239 5199 3449 7058 29110 4585 339366 256435 221981 196527 3443 727897 208 79875 81794 2719 6636 80070 6635 6637 3605 84061 79728 112744 10392 246213 3437 11282 55741 84313 11320 6205 6207 1185 55823 51304 3654 6209 8487 6185 23479 6184 476 23118 11218 23193 201595 3105 10000 746 481 483 51114 6732 486 5648 1603 2782 2785 59345 898 2783 2781 22938 10800 917 7027 611 1871 7029 10046 4854 4615 3725 6421 1398 130340 8546 1793 867 408 2194 5878 9785 653509 199746 729238 1438 8660 8322 7099 7474 7186 8323 8324 8737 23643 7322 627 2645 7046 5906 5594 5604 5605 2548 2542 57674 2678 2799 1585 1584 55236 378884 23649 3417 2801 1687 3178 54845 2060 4651 4644 57407 152926 10768 79792 4758 546 6948 2322 80306 5025 719 5501 10020 5507 8106 1977 28234 4548 2023 10728 5664 11224 162417 51107 55851 2288 6888 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery 11218 6230 6232 6231 6234 6235 2197 6636 6635 6637 140032 6227 6205 6229 6207 6209 8487 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 26063 3295 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 5295 3791 51411 6801 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 5295 10818 5781 2549 27006 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor 30849 57761 2322 3630 5781 523 208 2549 9965 2252 152831 27006 10312 50617 5295 5594 10818 3667 51606 245972 9296 5140 537 8660 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis 28 CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly 1992 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis 2172 54659 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs 11051 8106 51585 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation 5579 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 5688 1460 5689 5701 9978 1457 5714 5717 5718 5687 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins 5906 2244 5747 2243 1398 54518 2266 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport 5567 5568 2782 8766 2785 363 59345 5573 4645 2783 5576 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters 9990 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus 6868 408 142678 182 51107 55851 57534 5664 83737 3714 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation 7284 65003 51081 6150 28957 57129 51021 84545 51649 122704 9553 64981 10240 3396 118487 51373 740 51650 51253 54148 55037 9801 219927 51116 29074 10102 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA 5688 5689 5701 5714 5717 5718 5687 26986 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 5984 5985 6119 6118 10459 5982 5983 51455 5981 5111 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 335 348 338 4481 286133 117156 5648 7184 2495 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System 374 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 84335 7249 23608 10000 207 4193 208 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib 11140 55914 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection 11168 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly 3313 57128 4519 617 150274 7385 728568 7386 440957 SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer 5295 1956 2549 11140 55914 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria 79792 1687 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade 2239 221914 2719 9672 2159 2147 2158 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis 834 3002 25978 79643 79792 51652 836 1687 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 427 51606 523 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 3105 7322 5111 9646 7320 8347 3018 8348 85236 5591 7319 9810 7332 92305 220441 9781 5193 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion 11185 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 6129 6230 6232 6141 6231 2107 6234 6146 6235 2197 2935 51504 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling 26873 79094 2678 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling 3716 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation 4072 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism 653509 729238 1438 6441 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression 4520 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 51072 387 1956 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer 867 5295 1956 2549 11140 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 9900 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA 3178 57461 84844 56259 9360 5440 5441 79902 51729 22803 22938 8106 1977 9785 199746 7919 9984 79228 84321 10523 84081 6631 10929 11066 57794 10772 56339 51691 84950 8899 22827 9129 151903 55660 143884 23759 5411 56949 23398 63932 60625 6638 79622 51634 10594 57819 8559 10236 58509 51759 3181 11017 23524 10465 6627 5930 51639 8896 51645 24148 6636 6635 6637 6396 85313 57122 4927 10084 2962 11051 23165 5436 55746 51585 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 51422 79602 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 4582 394263 4585 727897 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking 10000 51552 207 7879 8766 22878 79090 54453 81876 2664 57465 23163 23682 11345 201627 5872 6764 5873 9230 414918 54662 9909 208 79961 26000 51399 60684 122553 7109 84079 9367 11337 7249 5878 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation 6119 6118 10728 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly 1308 3691 5339 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway 7846 7280 79861 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 11022 4603 5440 5441 5436 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity 3815 5594 7545 3376 7942 7341 4286 10000 257 9255 3065 1499 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin 64682 5688 11065 5689 10393 5701 5714 5717 5718 246184 51529 5687 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins 5747 6709 5317 329 4137 63967 1832 6304 5339 1499 836 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 2645 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 1144 1141 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 22894 23404 54512 1432 167227 51013 207 118460 5393 11340 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 30849 3105 6396 22872 51752 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 51230 10000 207 8900 4193 5527 208 117584 79109 64223 7874 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 7086 6888 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer 84335 7249 10000 207 4193 208 79109 64223 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes 9420 1585 4128 1584 191 26873 2678 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 8968 8347 3018 8348 85236 3014 8370 3021 10765 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation 27327 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 8322 7474 160 161 5579 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 5440 5441 51728 661 11128 10621 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis 27127 54386 545 10734 27030 8370 3021 5932 8968 6119 6118 8347 9126 3018 8348 10735 85236 3014 9985 7014 23353 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway 144165 5688 8322 5689 7474 8323 5701 8324 5714 5880 81029 57216 387 23002 160 161 5579 5717 5718 5687 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants 2322 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 11140 55914 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 3558 50943 1493 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants 5295 2322 5781 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer 4089 7046 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 3030 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands 627 3065 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay 23211 1797 124245 10200 91746 5393 8106 11340 22894 22803 23404 54512 51013 118460 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 5604 8945 1326 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors 1482 4880 204851 6910 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway 2771 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME 5446 28234 54659 5444 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell 867 2060 10254 30011 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD 26873 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle 9367 22836 898 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination 2966 404672 79101 7343 5440 5441 2071 2967 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 22977 4257 4259 2678 1800 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events 5332 4295 5583 129521 2151 23566 56413 2865 1133 9630 8525 6866 5032 94233 2782 885 5028 5029 2785 84432 139189 59345 1902 2783 6375 57121 11343 2922 4828 26575 10800 2520 5997 2846 9170 222545 10887 623 624 747 1607 1956 695 5295 7225 5594 2847 553 2147 2864 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs 51422 10645 53632 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS 254531 51365 11145 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation 5982 5983 84515 8318 5111 9837 51659 5984 5985 6119 6118 5981 23649 57804 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 653509 729238 1438 6441 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation 2782 2864 2695 1045 2922 1499 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization 5295 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress 1021 1029 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins 6866 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance 335 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions 50937 RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle 28964 22865 101059918 58504 81624 116984 55114 708 50508 5585 5586 23002 644150 23129 1536 1535 398 6709 29984 4646 157285 4649 2631 144402 10574 9826 4810 9828 22899 5361 8476 5880 10152 2010 85440 29843 387 84144 1793 613 70 26050 2802 3071 4162 10160 79180 7919 10163 1445 224 55831 10726 29127 128239 998 11135 8239 54509 5924 87 7879 4722 5825 11140 55914 182 5295 10818 4548 8502 8301 7126 390 29766 9352 22852 57216 1832 10505 253980 5783 23592 3895 10970 4296 23048 57580 10811 10810 80243 55843 29941 1730 5930 10254 3930 23616 7454 26049 7170 2040 55971 84317 143872 10788 55852 10144 27 57120 57480 23380 11329 57522 4983 537 51306 221178 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation 5295 3667 387 8660 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 1460 23193 1457 746 1603 6185 9159 1499 6184 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 9424 10089 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 5688 5689 5701 5714 8945 5717 5718 5687 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 161882 23067 8370 3021 3065 8968 8347 3018 8348 27327 85236 3014 2623 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism 231 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 4089 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation 387 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine 54386 8347 3018 8348 85236 3014 8370 7014 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 2782 2864 1045 2922 1499 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR 867 5295 6868 2060 10254 5781 30011 1445 1956 2549 374 998 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling 1956 5753 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 55854 340075 79642 89978 347527 51611 4733 285381 2107 2159 2147 2158 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes 83439 3065 1487 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade 712 719 629 4179 1361 1380 1369 730 713 735 714 2147 715 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation 5440 2962 5441 5436 2252 27006 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function 348262 5688 10009 5689 2060 23193 687 5701 5714 746 1603 3021 3170 3065 1460 5594 1457 3018 54971 85236 3014 7750 54737 117581 11171 8370 9159 2146 8968 5931 6929 6615 8347 27327 8348 4193 23028 5717 5718 6185 1487 1499 5315 93986 6184 5687 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones 10362 51317 8370 3065 8968 5931 8347 25855 3018 8348 85236 23028 79685 8819 54815 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling 23054 7099 571 64784 96764 10743 335 23643 113235 23373 338 8204 4208 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism 5336 51447 5332 5333 3631 9651 3633 117283 8867 55190 89869 79902 3705 3707 6396 57122 4927 3628 23165 9108 55746 55586 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells 4072 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants 5295 1956 2549 11140 55914 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere 54386 5984 5985 5982 5983 79075 79991 5981 23649 5111 7014 57804 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation 27006 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling 5295 5336 695 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 6648 3630 10000 2908 57060 2645 208 4852 3065 207 181 5105 4089 2538 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint 5688 5689 891 5701 5714 9133 5717 5718 5687 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 30849 25978 79643 51652 23479 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) 10038 6996 5982 5983 8505 5423 5111 5984 5985 6119 6118 4913 5981 57804 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation 11160 26127 5295 7750 613 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus 6396 57122 4927 23165 79902 55746 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 1956 374 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 60528 283 23405 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism 3630 4644 5873 1363 1215 2695 290 1511 1045 1360 57393 3626 1359 2028 3479 56605 23265 1636 2782 1361 2864 2922 1499 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling 9244 10148 7297 3716 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation 6996 7486 8535 7341 7508 367 7421 80012 2908 5914 6304 10401 79902 3065 648 5111 197370 79677 8924 51602 5371 7155 54780 3622 7703 29843 8370 23314 6396 9126 4286 10735 57122 4193 4927 8204 23165 4869 55746 1487 7518 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR 51284 7184 10695 81622 5641 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis 7186 355 330 8797 57162 8737 329 7332 11140 83737 10015 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 23118 7099 7186 23643 5594 5604 1432 8767 2243 5528 1326 4208 2266 2244 7335 28512 9097 57162 28511 4615 3725 695 6280 10392 51295 8945 3654 6271 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling 867 5594 10818 5781 27006 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 867 5295 5594 10818 5781 2549 9965 152831 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle 28964 5295 6709 4296 9352 7170 4649 998 8239 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle 23193 80267 10206 55741 5887 56886 84447 7844 55757 11236 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions 56896 9037 1400 1808 5361 4627 1020 387 23129 4628 5362 5365 1809 1072 9826 8482 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 5295 10818 5781 2549 2252 27006 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME 3290 54659 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis 1000 4917 1013 1002 1496 50937 4654 4656 6929 1432 4208 1499 998 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation 7341 6396 25909 57122 1104 23165 79902 55746 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening 781 774 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling 10000 207 4145 208 1956 11140 55914 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 728294 79944 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 5688 5689 5701 8535 1021 1437 5714 161882 5781 3558 80012 3977 23067 3021 3065 648 1460 1457 3018 26053 85236 5579 3014 5371 50943 83737 5275 23429 8370 8968 6929 4602 8347 55193 27327 8348 8861 5717 5718 2623 1493 5687 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 23118 7099 23643 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization 5371 7874 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 7474 83999 22943 6422 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol 84267 54482 348180 83480 51605 112858 93587 115708 113179 51002 51504 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway 545 80198 146956 79008 197342 55215 6119 6118 2176 2187 29089 22909 9937 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state 64682 5688 11065 5689 10393 51343 5701 9978 5714 84515 8900 51053 898 4998 5717 4999 5718 246184 51529 5687 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines 6367 51554 6348 6375 6372 6364 6357 3576 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling 355 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription 3224 3609 6615 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 10046 390874 22938 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases 28964 22865 101059918 58504 81624 80776 116984 55114 708 50508 3021 4771 5585 5586 286205 23002 644150 23129 1536 1535 398 3018 6709 29984 85236 5579 3014 4646 157285 4649 57551 2631 144402 10574 9826 4810 83540 5747 9828 22899 5361 8476 5880 10152 2010 85440 29843 387 2491 695 84144 6280 1793 613 70 51466 140735 26050 2802 3071 25936 4162 10160 79180 23028 7919 10163 64837 1445 224 81930 55831 10726 29127 128239 998 1499 11135 8239 54509 5924 11004 87 5594 1432 7879 1072 4627 5300 4722 6396 5825 57122 55746 367 79902 5525 5526 5527 5528 5529 11140 55914 182 5501 8655 1781 5295 10818 1778 4548 8502 8301 7126 6232 390 29766 9352 22852 57216 1832 10505 253980 5783 23592 3895 10970 10093 4296 25909 10097 10096 23048 1063 57580 10811 10810 80243 55843 29941 30849 1730 1058 79019 5930 10254 3930 23616 7454 26049 7170 8370 2040 55971 84317 2316 143872 10788 55852 10144 8968 348235 27 8347 4221 57120 220134 8348 57480 4628 23380 11329 57522 4983 537 51306 221178 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine 220074 4128 1312 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors 7253 122876 2492 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 3105 160 51606 161 130340 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD 191 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux 344 341 348 27327 221656 80820 23028 1071 55818 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown 23175 91754 2010 10783 255919 79902 23592 891 6396 57122 5579 4927 9133 23165 55746 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling 867 5594 5781 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance 23054 51422 4508 4509 96764 133522 80776 440574 56652 3418 10651 10989 10309 53632 11232 55735 345643 647309 64216 7978 159989 84808 3313 7027 2101 9662 8655 7840 1781 22995 22897 140735 7283 1778 4602 54930 27327 1453 11190 23354 80254 121441 55755 10806 10121 55835 7846 8636 10540 64784 5108 84131 4957 112752 28981 79989 255758 23373 347240 23265 1432 84100 2847 132320 8766 5311 55212 516 26123 9742 54806 4208 6608 51098 55764 6648 814 3054 51053 2747 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily 1728 8370 3021 8968 8347 3018 8348 85236 84181 8313 3014 3481 79843 1499 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis 10606 5471 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation 9630 2782 2785 59345 2783 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway 998 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation 3074 6548 11261 57214 3161 8372 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage 79792 836 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules 917 5336 7454 3115 3113 3702 51466 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation 2244 5688 50489 7099 5689 5701 3105 5714 23643 4615 695 3685 6280 1536 1535 2243 5717 6271 5718 9554 55176 2266 5687 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 9750 3781 129446 9381 27445 161497 10518 4627 55584 2059 5962 64072 829 4647 286262 490 494513 246213 6709 3779 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 7042 6929 408 27327 51107 5914 55851 4089 4654 5664 4656 7046 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade 196527 2160 5270 2159 2147 2158 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) 1958 5594 1432 7166 1020 5528 4208 3400 10221 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 867 7042 9958 11171 9110 5501 4089 3685 7046 23645 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 10000 207 208 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 130589 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids 57834 66002 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 51284 7335 4615 3654 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation 3630 3667 8660 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption 6523 6248 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism 178 5236 5834 5836 378884 5837 5507 2548 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 6480 256435 6482 6484 6487 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins 6749 23054 6883 56259 6882 5982 6884 5983 10200 79733 5440 5441 1870 1639 9156 6877 5111 6879 5984 5985 29851 3115 3113 5476 8655 1781 6830 140735 27125 4068 1778 4602 4300 10459 5429 51455 23308 8832 1380 59067 55860 64837 1512 27301 81930 10673 8722 29127 3111 10121 11004 10540 4094 10538 829 5393 11340 22894 23404 54512 51013 7879 118460 4627 9646 6929 8178 6873 144455 2962 54457 5981 5436 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) 9900 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy 51422 100188893 7335 7419 29110 7322 2034 7416 9927 8655 1781 53632 1460 140735 1778 1457 7332 123 9474 54543 55669 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress 545 7266 51182 27000 57805 9531 22824 116835 10728 79902 5594 3313 84335 6119 6118 6396 815 57122 2288 816 9532 4927 817 818 23165 55746 64223 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 7099 8737 23643 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle 87 29766 9352 7919 4646 11329 11140 10574 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer 7046 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP 7186 355 8797 8737 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling 344 345 335 348 338 336 337 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein 6396 57122 4927 1104 23165 79902 4869 55746 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing 3178 57461 84844 56259 9360 5440 5441 51729 22938 9785 199746 7919 10523 84081 6631 10929 57794 10772 51691 84950 8899 22827 9129 151903 55660 143884 23759 5411 56949 23398 63932 60625 6638 51634 10594 57819 8559 10236 58509 51759 3181 11017 23524 10465 6627 51639 8896 51645 24148 6636 6635 6637 85313 10084 2962 5436 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation 867 2060 10254 30011 1956 374 998 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system 2161 3818 2147 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling 23118 7099 7186 8737 23643 5781 7322 5594 5604 1432 330 329 8767 5528 1326 4208 7335 28512 9097 28511 29110 3725 10392 8945 3654 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis 10613 11160 5688 5689 5701 5714 5717 5718 5687 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly 51750 27158 51647 4682 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism 2023 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia 57407 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere 1058 79019 8607 51773 2491 8370 54069 5931 8347 3018 8348 85236 3014 4869 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation 2261 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis 917 5567 5336 5568 10768 5573 5576 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases 5688 5689 5701 9958 5714 8607 10445 7528 7046 221656 3054 580 5717 5718 5687 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 5295 1956 2549 11140 55914 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling 3449 5781 7297 3443 3441 3439 3716 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO 1630 6586 6585 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors 160 5579 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 55835 7846 8636 10540 5108 84131 4957 3161 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 23354 80254 121441 55755 10806 10121 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) 127833 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding 8301 7164 9026 130340 8906 8546 388552 2799 2495 6272 4074 2647 55330 54885 408 9829 5878 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 9152 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis 8204 5105 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels 30818 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors 81624 80776 367 50508 4771 3021 79902 5585 5586 286205 23002 644150 1536 1535 3018 29984 85236 5525 5579 3014 5526 5527 5528 57551 5529 83540 5747 5880 10152 5501 2491 387 695 8655 6280 1781 51466 140735 1778 3071 25936 23028 10163 64837 81930 10726 128239 1499 998 11004 6232 3895 5594 1432 10093 25909 10097 10096 1063 10811 10810 1072 29941 30849 1058 79019 7454 4627 5300 8370 2316 10788 8968 348235 8347 6396 4221 57120 8348 220134 57122 4628 23380 55746 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family 51422 23476 7004 57761 201595 7005 5294 10000 746 1603 3021 8463 53632 1460 1457 3018 85236 5525 3014 5526 5527 5528 3115 5529 3113 79109 917 3725 2034 151888 23533 83439 5295 23308 27327 8945 1445 5717 5718 1499 998 5687 10613 5688 5689 5701 5714 5781 9020 80380 3716 142678 207 1326 9978 8370 208 2146 11160 84061 8968 5931 8347 8348 6185 64223 1493 6184 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 2864 2695 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway 5688 5689 7186 7124 5701 5714 8741 9020 8744 3604 60401 23495 7132 4049 330 9966 329 8945 5717 10673 5718 5687 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation 5688 5689 5701 5714 5717 5718 5687 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand 2244 7099 51284 338 23643 2243 79792 6271 6280 1687 2266 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins 140881 140850 503618 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions 286 27255 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes 8720 81501 90993 10488 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders 6575 9843 9056 5002 10559 116085 2645 79902 9990 9152 246213 6530 6396 28234 6523 57122 4927 1836 30061 23165 553 55315 55746 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling 4627 4628 387 9826 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 116255 346606 84649 23175 150763 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin 4128 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 7846 7280 25978 79861 79643 51652 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 4121 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 388585 10046 9978 182 51107 55851 3065 10014 3714 6868 892 408 142678 57534 5664 83737 22938 1024 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C 64682 5688 11065 5689 10393 51343 5701 5714 5717 5718 246184 51529 5687 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer 5594 891 9978 2305 3002 29851 597 4869 3065 5551 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 151531 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle 6390 57128 644096 3418 6391 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects 100 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation 6749 8178 5440 2962 5441 5436 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway 127 10170 195814 57665 1381 8608 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching 6585 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 25946 79733 8900 144455 898 57060 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 545 7486 5982 5983 9156 5932 5984 5985 79728 6119 6118 5883 83695 580 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription 1958 7166 1020 3400 10221 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 387 1398 1793 5753 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 6119 6118 9156 5111 57804 RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle 29941 9828 81624 2040 5585 5586 613 70 23002 5295 398 4162 4649 57580 4983 29127 128239 55914 9826 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL 867 5295 29760 1398 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions 696 5493 7498 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation 23649 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death 7186 355 330 8797 57162 8737 329 7332 11140 83737 10015 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling 3313 6627 6648 829 3716 9244 10148 7297 3181 6888 3595 3594 759 3593 3592 1072 998 27250 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway 5594 5604 5605 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade 30849 57761 2322 3630 5781 208 2549 9965 2252 152831 27006 5295 5594 10818 3667 5140 8660 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome 55835 7846 8636 10540 5108 84131 4957 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 23354 80254 121441 55755 10806 10121 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism 9963 1528 9962 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 627 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 5295 10818 5781 2549 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 338 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 6480 256435 6482 6484 6487 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism 79581 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 5875 79370 64065 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism 161823 5105 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling 10148 7297 3595 3592 3716 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells 1499 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 7027 1871 7029 1021 898 1870 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis 10678 11046 10402 9435 176 9331 6482 6484 6487 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1975 1977 8106 26986 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 5264 26061 10478 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle 5930 9352 4646 11329 10574 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin 5688 5689 5701 9978 5714 8900 4998 5717 84515 4999 5718 5687 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 9136 10171 79050 22984 25879 9790 27341 10813 55226 51077 54555 84128 11056 55813 55505 51504 92856 51118 1736 51602 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB 5567 5568 5573 5576 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity 5688 5689 5701 5714 4193 5717 5718 5687 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli 23054 50488 9448 154743 5520 9681 116138 8912 8720 23334 3009 3007 3006 10266 3021 4217 25842 5586 9361 10113 64344 23677 27230 1536 4496 1535 652968 3018 2081 85236 79726 8994 3014 2882 5747 30827 84447 475 140735 84335 22872 3791 5717 5718 1499 5687 5688 5689 5701 8535 5714 335 80012 5393 648 11340 2673 22894 23404 54512 1432 167227 51013 207 118460 5573 79094 4208 5576 5567 5568 9978 6124 6130 6396 4199 815 816 9532 57122 817 4927 818 23165 10294 55746 6128 6129 6141 1021 6146 1870 79902 1639 1030 6156 5526 6159 11331 6168 6169 6160 6170 27327 7184 246184 51529 1029 64682 11065 10393 1728 51343 6230 6232 6231 6234 6235 2197 140032 23373 7296 6227 6229 208 79728 7086 245972 6205 6207 6209 96764 10000 523 10312 2782 9296 5029 2785 59345 2539 898 2783 5027 7027 1871 7029 3725 2034 374 55620 5753 59341 7099 64784 10743 23643 7322 829 8894 5594 1968 51606 338 8900 1337 6648 571 23657 1339 1350 1345 6119 6118 28956 4193 6737 64223 3417 3576 545 57761 367 2908 4520 1460 1457 84181 79109 7014 54386 3313 8655 1781 1778 84962 8945 55860 613227 10121 7266 10540 51182 27000 57805 9531 22824 116835 10728 81501 90993 10488 11224 23645 25994 8370 3685 405 113235 2146 8968 5931 8091 10897 8347 84560 2324 8348 55466 2288 4501 8204 4502 6888 5175 81502 10641 1032 1031 729438 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME 54988 10249 341392 10720 389396 54579 574537 7363 8824 54659 1558 1565 10941 133688 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease 5295 10818 5440 2962 5441 2549 5436 2252 27006 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids 64682 5688 11065 5689 10393 11004 5701 6232 5714 80776 79902 25909 5525 5526 23063 5527 1063 5528 57551 5529 83540 1058 79019 2491 5501 8655 1781 140735 348235 1778 25936 6396 9126 220134 10735 57122 5717 81930 5718 10726 55746 246184 51529 5687 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs 10540 367 10728 2908 829 1639 8655 1781 140735 1778 2288 55466 55860 10294 10121 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines 54496 8968 5931 55193 3014 8370 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins 5317 1832 1499 836 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response 5688 5689 1642 5701 9978 7341 5714 8370 2138 8347 3018 8348 85236 23030 3014 8924 580 2140 5717 322 5718 5687 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation 5532 10768 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage 836 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited 7186 355 8797 8737 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 7186 355 8797 8737 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis 5027 5025 6543 6786 7225 6546 490 80228 491 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins 7341 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER 5984 5985 6119 6118 5982 5983 5981 5111 57804 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport 10613 5688 20 5689 5701 335 5714 11160 8894 1968 5825 5717 5718 10058 23 5687 10351 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry 7099 2239 23643 5878 221914 1956 2719 9672 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease 167227 57819 RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs 4627 4628 4771 2316 998 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) 5027 834 29108 5025 79792 719 1511 10910 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA 150763 254531 137964 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation 55835 7846 8636 10540 5108 84131 4957 728642 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 27229 23354 114791 80254 85378 121441 55755 10806 10121 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm 3170 4089 1499 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se 27232 875 191 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants 2322 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K 154807 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib 11140 55914 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels 3065 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9420 1581 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts 9420 5825 1581 23600 10998 51302 3295 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 836 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) 51305 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 5295 10818 5781 2549 27006 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils 7092 4016 84695 7837 649 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 5906 2244 5747 207 2243 1445 1398 2147 150 54518 2266 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus 6396 57122 4927 23165 79902 55746 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 3479 3481 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA 64682 5688 11065 5689 10393 51343 5701 5982 5983 5714 84515 8318 9837 5111 51659 5984 5985 8900 898 9978 6119 6118 51053 4998 5717 4999 5981 5718 23649 246184 51529 57804 5687 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 8968 8347 3018 367 8348 85236 3014 23028 8370 3021 5585 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 3002 3021 3065 3714 23129 892 3018 85236 3014 22938 7027 1871 7029 23286 10046 4854 2208 182 10402 3725 1999 1956 408 4192 27327 5717 57534 5718 5687 5688 5689 388585 5701 5714 10014 6868 142678 207 5664 83737 6484 6487 9978 51107 8370 55851 8968 8347 8348 2324 1024 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 387 INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling 50615 59067 3716 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions 5295 87 6709 9863 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud 2668 3207 10736 2138 3237 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 3030 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin 3479 3630 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 5688 10920 5689 1642 5701 5714 7322 64326 64344 154881 84961 6468 23014 27252 9978 25879 25793 11275 28952 79016 2034 55884 23363 64410 123879 26094 26259 8883 54939 144699 79269 122416 79728 140825 5931 84727 146330 92591 140460 80176 8945 54620 53339 5717 5718 64708 50813 5687 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 55620 5753 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production 2678 1800 10800 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins 84061 201595 7341 335 3840 746 1603 6185 4836 6184 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport 4508 4509 91942 347411 4707 4708 3418 79944 4701 29090 4710 4519 4712 4714 6391 3313 6390 4540 4541 23530 4538 7385 7386 83733 64777 51295 25880 51103 617 192286 613227 10048 5091 57226 7416 6341 4696 51241 10131 55967 516 55969 440957 4728 1337 25994 9481 57128 25874 4720 150274 4722 4967 1339 9997 1350 728568 1345 644096 4199 116228 728294 4190 3420 28958 4191 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome 834 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes 2673 30827 27230 10897 116138 22872 84447 5526 1639 10113 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade 23118 7335 7186 28512 9097 28511 8737 29110 3725 7322 5594 10392 5604 1432 330 329 8945 8767 3654 5528 1326 4208 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes 344 8720 337 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair 4913 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants 3815 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 5295 10818 5781 2549 9965 152831 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 4781 6741 5440 5441 51728 661 11128 10621 SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism 10955 347735 619189 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 7027 7029 91750 7298 8900 1876 898 4998 8318 3065 5111 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation 3082 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 6530 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis 51422 23054 4508 4509 64784 96764 133522 440574 56652 3418 10651 10989 53632 11232 23373 55735 1432 64216 7978 84808 516 4208 3313 2101 6648 814 3054 2747 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 197342 79728 7486 580 9156 80198 146956 79008 5932 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids 57834 1565 66002 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 5819 917 11314 27036 10288 6614 3105 3820 120425 27180 135250 4068 7087 909 131450 4267 56253 353514 23547 5817 340205 3805 29121 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential 51305 54207 3776 50801 9424 10089 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency 5091 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles 2327 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 2538 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange 545 7486 5982 5983 9156 5932 5984 5985 6119 6118 5883 83695 580 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type 405 66002 29785 9420 5447 57834 1585 1584 1558 1581 1565 51302 9915 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea 9750 129446 9381 27445 161497 10518 4627 2059 5962 64072 829 4647 286262 490 494513 246213 6709 3779 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling 22808 5501 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) 4056 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 64777 25874 10048 4199 347411 5091 7416 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism 8789 5210 11046 5834 5836 5837 130589 79902 8372 10675 3074 11261 5207 5208 5209 124872 2539 10690 5528 3161 3038 2538 10855 4125 5214 6548 10402 9435 2597 5507 178 1836 5105 9331 2023 64132 3906 10678 55276 9348 57214 90161 5236 176 9956 5091 2645 2821 26035 51071 2026 51000 23729 221914 6482 9672 337876 2548 6484 231 51084 6487 5567 2542 5568 2239 6120 2719 2799 7086 6396 28 57122 4927 6888 23165 378884 8707 55746 9917 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes 5984 5985 10459 5982 5429 5983 51455 27301 5981 5111 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex 7027 7029 91750 3065 5111 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants 2322 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D 2799 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine 875 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 5688 5689 5701 9978 5714 8945 5717 5718 5687 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation 23163 3630 335 51107 337 8370 55851 9027 3021 9445 6653 23555 340348 325 8968 54959 8347 3018 348 8348 85236 2243 3014 8239 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling 338 4547 1071 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases 2322 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex 5984 5985 1642 6119 7320 6118 5982 9978 5983 5981 5111 57804 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins 64682 5688 11065 5689 10393 5701 5714 891 8900 5717 5718 246184 51529 5687 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization 1308 1306 1286 1293 1303 80781 1287 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates 7296 7298 4830 4833 205 10201 102157402 6240 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling 57610 10048 3082 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 7027 891 25946 7029 5111 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling 30849 57761 2322 5781 208 2549 9965 2252 152831 27006 5295 10818 3667 5140 8660 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism 9390 83594 92014 23057 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 3611 55742 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication 2060 23193 3224 3609 746 1603 3021 3065 1460 1457 6709 3691 3018 54971 85236 3014 5339 54737 5747 9863 9159 1793 5295 6615 27327 9076 1009 23028 5717 5817 5718 1487 1499 998 5315 93986 5687 5819 348262 5688 10009 5689 687 87 5701 5714 5781 64398 283 3170 3716 5594 3611 55742 81607 5818 329 29780 1012 7750 54751 7297 253559 137075 7016 64403 9075 28513 80149 221935 1308 1010 117581 1000 10326 1006 1013 1004 1002 1001 11171 8370 2316 2146 8968 5931 6929 8347 8348 4193 6185 6184 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A 2159 2147 2158 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins 10195 5476 4758 79053 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 64837 387 998 3895 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 545 7486 5982 5983 9156 5932 5984 5985 6119 6118 5883 83695 580 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium 84100 2847 55212 6608 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs 5747 7454 10152 695 644150 5594 3071 10093 10097 10163 10096 10810 998 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events 93343 7251 5119 25978 51271 79643 8370 51652 79902 8968 8347 84313 6396 3018 8348 85236 57122 4927 23165 55746 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins 7341 6396 57122 4927 7155 10401 23165 79902 5111 55746 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis 1482 55897 6899 8861 4089 4208 6910 1499 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 23118 79792 5528 5336 28512 9097 57162 28511 4615 3725 695 6280 5641 51295 8945 7184 81622 7099 7186 64145 8737 23643 5781 7322 51284 5594 5604 1432 330 338 329 8767 2243 10695 1326 4208 2266 30849 2244 7335 29110 3684 80231 9450 3663 10392 3654 6271 1687 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h 79053 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 9420 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 64216 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation 64682 5688 11065 5689 10393 51343 5701 5714 3021 84515 8318 3018 85236 3014 8370 8968 6119 6118 8347 8348 51053 4998 5717 4999 5718 23649 246184 51529 5687 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation 84335 815 2288 816 10728 817 818 64223 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins 23193 6480 201595 7341 746 256435 51114 6732 1603 84061 11282 55741 51125 11320 4249 51304 6482 6185 6484 6487 6184 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 8660 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants 5594 5604 5605 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily 6627 6749 84844 51639 22827 8370 3021 4654 6636 6635 4656 6637 8968 9646 6929 6638 8347 3018 8348 85236 3014 10523 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport 9843 523 94033 113235 2495 10312 50617 51606 48 245972 9296 30061 537 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors 10765 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation 7186 23586 28512 28511 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A 64682 5688 11065 5689 10393 5701 5714 8900 5717 5718 246184 51529 5687 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle 28964 81624 8476 55114 2040 57120 7879 23048 23380 57580 4983 144402 128239 998 11135 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription 10025 133522 113835 5440 5441 23067 3021 3065 9440 7581 2966 892 3018 85236 5579 3014 9439 54815 2967 51230 79862 7700 5105 5717 5718 1499 8239 5687 5688 5689 5701 8535 5714 4094 80012 648 10014 7528 1432 348 207 4208 30818 83737 728957 168374 5816 29028 155061 117581 9978 4605 5275 121274 29959 79088 54487 84671 9997 4852 284443 6910 65123 7582 57508 100289635 1482 23248 163255 54973 9646 23269 25896 6929 6618 388567 6617 8178 814 55726 815 6873 79035 816 817 818 11051 2962 22869 54457 4089 9534 5436 1493 284309 51585 100131980 51422 283337 6749 22835 10172 6883 7004 6882 7005 6884 1021 84914 3558 57541 147741 2103 90594 90233 6877 8463 6879 1030 51333 26974 65988 79230 25888 339327 26053 353274 57209 286075 181 5527 126068 7703 50943 163081 7712 442319 7711 147949 57474 91120 80110 182 390927 221044 3172 4336 5308 23429 1876 84626 51385 23660 171392 7738 7753 441234 23314 144348 7625 7627 114026 27327 84527 6046 4488 7757 8861 90874 79047 284252 162972 246184 148213 51529 148203 1029 148206 64682 7769 11065 80032 10393 374928 51343 148103 126231 1437 140612 5781 10432 3977 349075 163049 163051 2821 463 163050 654254 84775 7549 7296 112950 3930 208 6636 6635 6637 2744 3654 10000 2539 898 2538 22938 7027 834 7029 10046 4854 3725 83439 4602 7249 2623 355 8797 161882 627 2645 5594 8900 1337 6648 3630 5300 79370 57060 1339 117584 1350 7832 84289 10650 5932 57472 55215 1345 6119 6118 9125 2176 28956 4193 144455 204851 29883 4869 64065 64223 7874 8445 545 5325 25946 7486 5982 7341 5983 367 133746 79733 7421 27166 2908 55367 5914 5457 835 9156 5111 64769 53632 1460 5984 5985 8738 91875 5883 1457 54971 5875 83695 5371 580 112858 3622 79109 133383 51755 27165 2101 1956 8106 6830 27125 891 4300 55193 10765 613227 55835 3815 9862 285676 1020 8370 405 2071 51003 2146 197320 8968 5931 404672 8347 4221 8348 25799 79837 84911 9915 1024 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation 2322 5781 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME 27233 6783 2952 2678 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np 55733 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts 1977 6396 57122 4927 23165 79902 55746 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 25946 57060 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 8091 3009 3007 3006 25842 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 93343 7251 51271 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 4913 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 5594 3630 4193 1020 627 405 9915 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation 57761 5294 10000 208 9020 23533 5295 207 5525 5526 5527 5528 1326 5529 79109 64223 1493 998 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis 79048 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 6227 6229 22928 6156 6159 11224 6168 6169 6160 6124 51091 6130 6170 60678 6205 6207 6209 6128 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis 5594 26276 57674 51606 11151 7879 6421 4843 1511 2023 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 3030 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation 7092 649 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle 28964 81624 8476 7454 2040 5295 7879 23048 57580 2631 4983 144402 128239 998 11135 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 5688 5689 5701 51230 5714 4193 64326 5717 5718 5687 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus 79902 6396 60528 79074 57122 10799 4927 51493 79897 23165 11102 10248 55746 10775 51637 10940 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions 5621 8911 1286 8912 2668 1293 1287 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 9965 152831 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling 10312 50617 3630 51606 245972 9296 523 537 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 5295 10818 5781 2549 9965 152831 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 5688 5689 5687 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling 50943 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion 55006 25821 54931 79693 9692 3028 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle 9927 55669 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport 9117 11196 23243 64689 5537 10960 374 51399 122553 10113 7109 6396 22872 1453 79090 81876 9554 2801 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle 898 5753 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase 54386 1736 51750 10856 23243 8900 8607 5537 80119 7014 55505 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) 4615 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate 1468 23474 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 5688 144165 8322 5689 7474 5701 8324 5714 57216 5717 5718 5687 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism 94101 253782 5660 427 3074 347527 2531 2583 204219 388931 81849 7368 10825 4758 8877 6487 340075 53947 5476 166929 29956 6609 55331 4074 79642 10715 9331 64781 130367 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance 28964 8912 2107 65110 9355 4440 6585 3199 1287 2935 23129 6709 1286 1293 9826 5747 5361 2549 387 1796 1793 51466 30011 5717 7225 5718 998 8660 5687 5688 5689 2043 5701 5714 5532 26986 5594 5604 5605 5576 5362 5365 1072 1809 8482 56896 1400 1808 5567 5568 9978 4627 6124 6130 6128 5621 8911 6129 4651 6141 6146 2044 22885 11280 2050 1460 2049 2047 3897 56963 10486 160 1457 220164 161 287 6156 6710 6334 6159 285704 57453 57731 57698 5649 8633 1630 6168 2668 6169 6160 5962 1956 5295 6170 10818 8861 10048 6230 6232 6231 5781 6234 6235 6586 2197 140032 6227 10093 286 6229 27255 10097 10096 5664 11224 9037 4318 51107 1020 55851 3685 9495 27 6205 6207 4628 23380 57522 6209 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins 8535 7341 80012 7703 648 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization 1287 3691 1286 1293 871 4016 5479 84695 5339 7837 3913 6641 6443 6640 6442 4146 6444 63923 8076 10516 2006 2201 2200 6645 1837 8082 780 54221 3908 4038 7087 3791 87 5340 6650 176 1215 1511 80781 3818 836 4326 4327 6868 10753 50859 9510 9313 4321 164656 2243 7092 1303 23473 4312 9672 5644 11132 5645 2266 649 7042 2244 4316 80274 1308 4318 1306 4319 3684 3685 51399 5175 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance 7486 5982 5983 79075 79991 23243 5440 5441 5537 51773 54069 80119 3021 5111 5984 5985 51750 3018 85236 8900 3014 7014 54386 546 1058 79019 10856 8607 2491 8370 55505 5931 1736 6119 6118 8347 8348 4869 5981 5436 23649 57804 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade 23118 7099 7186 8737 23643 5781 7322 5594 5604 1432 330 329 8767 2243 5528 1326 4208 2266 2244 7335 28512 5336 9097 57162 28511 29110 4615 3725 3684 695 9450 6280 10392 51295 8945 3654 6271 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 22894 23404 54512 167227 51013 207 118460 5393 11340 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism 5294 137964 8895 9489 23760 1120 51552 1460 80339 162466 10809 9362 1457 84649 55500 54675 56994 114971 55224 51365 11343 11145 81490 8904 56261 57153 3030 79143 171586 23175 150763 254531 50487 4534 23533 5295 55300 81544 9107 8867 5783 9110 22874 9108 22876 30849 3631 126282 284161 5287 79837 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus 8347 3018 8348 85236 3014 6732 8370 3021 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function 145226 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 147945 11277 197358 29110 5591 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 103 104 403314 339 10930 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 335 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis 2161 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 9355 490 6340 2782 6709 6339 6338 1208 611 255022 54795 5145 5158 335 336 145226 337 829 344 345 338 348 4627 4836 3779 9750 3781 129446 9381 27445 161497 10518 2059 5962 64072 4647 286262 494513 120586 8861 83756 120065 120066 81696 50831 50833 50832 50834 50837 50836 50839 50838 6121 131890 55584 391211 50840 81285 9626 504190 256892 390058 26532 390059 26658 26539 26538 341276 5957 343172 390063 390064 390066 221914 79541 10170 282763 9672 283694 283297 133060 8608 219429 5726 54429 126370 390151 2239 80835 120787 54884 5475 442191 390167 390326 2719 144124 144125 283159 403253 401993 259289 391107 246213 259287 259286 259285 81797 81399 26696 259293 259292 259290 259296 259295 50700 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence 7027 5594 1871 7029 1021 27327 4193 1870 1032 1031 1030 1029 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 5567 5568 5532 5576 9495 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib 11140 55914 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants 3815 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation 5236 176 130589 79053 10675 2673 3074 9510 221914 79947 4758 9672 6487 9037 4582 394263 5199 2239 4854 7058 4585 339366 221981 5476 727897 79875 81794 10020 2719 80070 10195 1836 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production 4843 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins 23479 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot 5328 6281 5271 5340 5270 5269 5327 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic 140735 1778 5049 10540 23299 636 55860 829 1639 8655 1781 10121 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs 27327 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 2239 221914 2719 9672 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism 443 339896 339983 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 57461 10920 1642 9978 5440 5441 2071 56949 404672 2966 5436 64708 7874 50813 2967 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway 5594 5604 5605 5778 5525 5526 5527 5528 5529 11221 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells 867 5295 5336 146433 5781 DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle 57407 435 162417 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 89978 51611 285381 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC 4582 394263 4585 727897 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 571 81502 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants 1487 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 3992 60481 9415 64834 3295 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System 23054 5440 5441 3021 1536 1535 3018 85236 5579 3014 6786 80228 5336 5476 695 6280 51466 23533 140735 22872 7087 909 131450 30011 4267 56253 1445 353514 5717 23547 5817 5718 340205 1499 3805 29121 5687 5819 10613 5688 27036 5689 10288 5701 6614 3820 5714 120425 27180 4094 135250 10538 5393 11340 22894 23404 54512 142678 51013 207 118460 1326 83737 11314 5567 5568 9978 11160 9646 6929 8178 6396 6873 2962 54457 6271 5436 1493 51422 23476 6749 6883 7004 56259 6882 5294 7005 6884 29760 1870 1639 6877 8463 6879 7318 160 161 5525 29851 5526 5527 5528 5529 7498 5295 10459 51455 27327 246184 51529 64682 11065 10393 51343 5781 3716 8767 2243 2266 2244 30849 7335 208 84061 51752 6185 6184 23118 201595 3105 10000 746 10200 6494 5966 26191 1603 23108 4794 5795 6468 917 4615 3725 2034 130340 151888 83439 4602 1380 64837 81930 29127 998 7099 11004 5532 23643 7322 997 829 5906 154881 7320 91694 23608 79654 84961 7879 8924 51444 7319 22888 7332 64320 6049 25831 23014 27252 64718 642 57674 25793 11275 4627 55658 54926 4591 51619 64410 55182 26259 51465 144699 9730 25898 84727 146330 92591 140460 80176 54620 55236 144455 53339 6737 64223 57761 5982 5983 5493 79733 9156 5111 53632 1460 5984 5985 1457 10768 3115 79109 3113 3702 9554 55176 50489 8655 5641 1781 6830 27125 4068 4300 1778 5429 23308 8832 59067 8945 55860 1512 27301 10673 8722 3111 10121 10540 9020 80380 696 5930 7454 8370 3685 2146 8968 5931 8347 8348 5981 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases 55593 10392 23586 8737 8767 387 55611 54764 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement 1401 1675 712 10584 629 5648 713 714 715 MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction 476 8911 5350 29766 481 8912 483 4880 486 54207 3776 50801 6543 6546 490 11280 491 7140 4607 6588 58498 7139 7111 6334 7137 10768 23630 7273 29098 6786 140465 30818 80228 3784 4635 51305 7170 6910 9424 10089 1482 815 816 817 204851 818 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs 7166 5781 1020 627 387 2549 1398 3400 10221 5906 1958 5295 5594 5604 10818 1432 5605 160 3667 161 5528 4208 8660 6014 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery 3178 6230 6232 6231 6234 6235 2197 140032 6227 6205 6229 6207 6209 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events 5594 5567 5568 814 815 816 10645 817 818 5573 5136 5576 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors 9038 1133 3362 3350 1816 1815 150 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate 5460 79923 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors 5688 5689 5701 3105 9978 5714 1104 79902 130340 160 51606 6396 161 57122 8945 4927 11168 5717 23165 4869 5718 55746 5687 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 144233 57510 5440 5441 54487 23405 5436 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins 5604 5605 10015 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response 5594 22900 836 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema 2161 3818 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 79728 7486 580 9156 5932 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription 687 11171 3170 93986 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR 5332 10000 2771 4295 5583 10266 129521 2151 23566 56413 2865 9630 1133 8525 6866 5032 94233 2782 885 5028 5029 5579 2785 84432 139189 59345 1902 2783 6375 57121 2922 9826 4828 2781 10800 26575 9038 2520 3362 611 5997 2846 9828 3350 22899 9170 222545 30817 10887 9340 623 50835 624 53829 747 2832 1607 2831 387 2695 26166 695 10268 1903 10267 84152 23533 338398 2843 85397 7476 408 445328 3792 7478 27115 10888 2852 2696 2859 2870 7225 63940 7480 998 5739 2587 5732 8322 5733 5924 7474 8862 8323 26086 8324 2918 9560 9283 5532 259294 2780 6343 6348 23596 9290 9294 59350 1325 2532 353164 5368 5594 207 5573 5576 553 6608 5567 5568 4852 814 815 816 817 818 1816 6372 1815 6364 6357 3576 6367 51554 5294 7253 122876 2492 5140 10768 10846 5528 5136 11343 150 50940 10645 719 1956 5295 83756 50831 50833 50832 50834 50837 50836 50839 9568 50838 50840 5660 2847 57580 2147 5726 54429 80835 1020 208 259289 259287 259286 259285 2864 259293 259292 259290 259296 259295 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress 8894 1968 11331 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation 5594 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling 5747 10093 10097 10096 387 998 1072 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 23054 6319 60481 10025 133522 3021 9440 63924 892 3018 84649 85236 2167 3014 9439 11343 22822 9862 23175 1020 8370 51003 8968 8347 84962 8348 123 1024 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation 5730 23414 268 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation 3313 4508 55735 4509 516 440574 10651 10989 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 7099 7335 330 8737 329 23643 7322 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs 25888 6636 6635 6637 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA 11168 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry 11314 7301 2239 22924 2719 4061 5295 7318 160 161 9076 55236 221914 9672 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell 6868 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B 64682 11065 891 10393 246184 51529 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) 55211 7004 284355 100288687 503835 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation 23054 7124 96764 10025 9862 80306 9440 51003 688 6517 892 112950 9967 2167 5105 9439 7480 1024 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 51107 55851 5664 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 5567 2172 51099 5568 2171 2170 2167 8228 5501 11343 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) 1536 1535 3685 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response 836 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade 2782 5158 5957 5475 131890 9626 4836 5145 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling 627 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 79728 7486 51750 580 9156 5932 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection 6749 93343 6883 6882 6884 3105 7251 25978 51271 79643 5440 1104 5441 51652 79902 6877 6879 4836 2966 160 161 11168 2967 130340 8945 5717 5718 5687 5688 5689 5701 5714 51606 9978 2071 404672 8178 6396 6873 57122 4927 2962 54457 23165 4869 5436 55746 7518 10015 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System 8662 427 8663 51386 3646 4125 5336 4128 5476 79923 90865 23533 1958 51295 22872 30011 4257 81622 10613 3554 712 5236 6993 51071 115004 11314 51411 11160 8672 9646 6271 51422 23476 56259 5294 29760 8566 1870 1639 51552 2634 4939 47 2633 3840 29851 1992 272 51447 7498 178 10459 51455 7184 5591 2821 5873 51752 51728 661 11128 10621 10200 10910 9447 5027 834 29108 3082 151888 83439 4602 4179 1361 1380 1369 730 64837 713 10019 735 81930 714 29127 715 998 5315 11004 64145 829 290 8894 1968 9244 10148 51606 7879 4843 3181 3595 3594 10695 3593 3592 1072 27250 6627 6648 4627 5300 2176 2187 28956 144455 4869 64223 6364 3576 6367 3609 5982 5983 7341 79733 835 8895 9156 5111 53632 1460 5984 5985 1457 5371 3115 79109 3113 3702 9554 55176 8904 50489 57153 8655 1781 6830 27125 4068 4300 1778 5429 23308 8832 8945 59067 55860 1512 27301 10673 8722 3111 9474 10121 10540 1832 1511 3818 9020 836 80380 10970 8744 3604 6868 60401 23495 4049 9966 10093 10097 10096 4312 10810 5645 696 4318 5930 7454 2040 8370 2316 10788 2146 8968 5931 27 8347 8348 4502 5175 23054 708 5440 5441 4771 3021 644150 1536 1535 6709 3018 85236 5579 3014 6786 80228 5747 2208 50615 5880 10152 6278 5068 695 6037 503618 6280 475 80341 51466 140735 84659 3347 114770 140881 3071 1113 3346 7087 909 51297 140850 131450 417 4267 10163 5657 56253 1445 51248 353514 5717 23547 5817 5718 340205 1499 3805 29121 5687 5819 5688 54509 27036 5689 10288 5701 6614 7124 3820 5714 3596 120425 27180 4094 135250 10538 6348 5393 8741 11340 22894 23404 54512 7132 1432 330 51013 142678 207 329 118460 1326 4208 83737 5567 5568 10326 9978 3684 80231 9450 3663 1675 6929 629 8178 6396 815 6873 816 57122 817 4927 818 2962 54457 23165 5436 1493 55746 6749 6883 6882 7004 6884 7005 3558 79902 6877 6879 8463 3074 23586 7318 160 161 5525 5526 5527 5528 5529 5295 147945 11277 3667 197358 103 27327 246184 51529 64682 11065 10393 51343 6230 6232 1437 6231 5781 6234 3977 6235 3441 2197 3439 3716 140032 51284 6227 51125 6229 8767 2243 2161 7297 2147 2266 2244 30849 7335 4582 394263 5199 3449 29110 4585 196527 3443 727897 208 3605 84061 112744 10392 3437 23200 245972 6205 6207 3654 6209 6185 5269 6184 5328 23118 5049 201595 3105 10000 746 5778 146433 6494 5966 5648 26191 523 1603 23108 4794 5795 10396 55593 10312 50617 1401 10584 9296 6468 8877 917 28512 9097 57162 28511 4615 3725 2034 387 1398 130340 1793 2495 867 5878 1438 5618 8660 7099 7186 8737 5532 23643 7322 997 5906 5594 5604 154881 9180 7320 81603 91694 23608 22875 338 79654 54472 55223 84961 2206 8924 26095 51444 80301 7319 22888 64170 3430 7332 3664 64320 2548 3669 6049 2352 25831 3560 23014 124583 27252 388697 64718 967 642 57674 3575 5771 25793 83716 11275 3588 55658 127829 54926 10493 4591 3240 51619 8809 64410 3597 55182 5896 26259 2799 5897 51465 10379 144699 7850 9730 5787 25898 5547 84727 146330 353189 10475 92591 64109 140460 284266 80176 57826 54620 55236 170482 53339 163702 6737 4033 55313 5005 326624 3417 29949 79097 1687 6590 5273 11074 57761 4651 5036 4644 29952 5493 53832 154664 7006 5834 9545 6041 5836 10394 282618 9342 79132 3916 7294 3920 170506 26253 51719 3600 5317 3608 64806 388646 10768 84418 79792 4758 10855 3313 2322 6947 2444 719 5641 1977 57554 55276 5660 5783 759 3685 2171 6888 5981 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 5825 1581 23600 10998 3295 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint 5688 5689 1432 5701 9978 5714 8945 5717 5718 5687 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer 388585 10046 9978 182 51107 55851 3065 10014 3714 6868 892 142678 57534 5664 22938 1024 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes 1308 1306 1286 1293 871 7092 1303 5479 80781 1287 649 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER 10038 1642 5886 5887 9978 7341 7508 10401 2071 6119 404672 2966 6118 2967 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway 23118 7186 7132 7124 330 8737 329 81858 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity 10368 160 815 5579 816 4193 4646 817 818 9495 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 594 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation 22999 10815 7915 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes 23760 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function 580 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 4056 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate 6119 6118 23649 5111 57804 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF 729238 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling 23118 5688 7335 5689 29108 5336 5701 5714 5532 7322 997 9020 8945 10768 5717 64170 5718 5687 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing 51125 51114 9986 58489 51104 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage 84164 51008 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle 28964 81624 55114 23592 1536 1535 7879 57580 55914 4810 3930 5880 10152 2010 55971 1793 613 143872 26050 5295 3071 4162 10163 4983 29127 998 11135 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 5594 3630 27327 4193 2908 1020 627 405 30818 9915 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules 10380 27233 6783 50512 25830 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions 23118 11218 3105 10000 5648 79902 23586 6230 6232 6231 5781 6234 64398 6235 3441 2197 7284 3439 3716 140032 51284 26276 6227 65082 6229 207 8767 7297 6441 30849 7335 64601 3449 29110 3443 208 6636 6635 6637 3605 112744 10392 6396 6205 57122 6207 4927 55823 3654 23165 6209 8487 55746 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 10352 25973 57505 27068 2617 51067 124454 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 4128 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation 51601 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor 150 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis 30849 8737 57551 79109 64223 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis 2244 196527 2243 2160 2159 2147 2158 2266 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 7027 7029 91750 4605 3065 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 3362 3350 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 6868 142678 182 57534 3714 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism 57407 130589 79053 10675 3074 549 9420 152926 10295 26873 4758 2538 435 6948 4128 4854 5476 10020 5507 51293 653509 729238 1836 4548 1438 55788 191 686 5236 176 5091 26275 2673 100 9510 326625 221914 79947 9672 6441 2548 162417 6487 594 9037 4582 2542 394263 5199 2239 7058 4585 339366 221981 727897 79875 2719 81794 80070 2678 2799 10195 1585 1584 6888 378884 3417 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS 1432 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids 54988 10249 341392 389396 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins 349667 94005 7512 390243 146183 58530 8581 146760 251 80740 4061 2822 55650 1048 51299 54872 6975 7007 10232 84992 10026 360226 2350 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS 4128 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 83733 9152 246213 6530 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors 2846 5032 5028 5029 53829 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 23586 8737 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation 5594 23314 367 221044 4094 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 27230 6227 6229 6156 6159 11224 55176 6168 6169 6160 6124 6130 6170 6205 6207 6730 6726 6209 6128 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection 93343 7251 25978 51271 79643 51652 79902 3018 85236 5371 5119 8370 1956 8655 1781 2146 140735 8968 5931 1778 8347 84313 6396 8348 57122 4927 23165 55746 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres 7042 8076 10516 3685 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 51230 10000 207 8900 4193 5527 208 117584 79109 64223 7874 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism 9615 7498 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 5778 3558 51114 6709 5525 6710 5526 5527 9986 5528 58489 57731 5529 51104 5747 5245 2322 3725 2668 3082 5501 1956 374 9965 2252 152831 27006 5295 10818 408 3667 27327 1438 1445 221002 5717 5596 5718 2118 998 8660 283455 5687 57554 5688 5689 5924 5701 10048 1437 5714 5781 22808 11221 54518 3716 5906 3815 5594 5604 5605 51125 4296 2243 7297 2266 3560 2244 5567 5568 9978 161742 200734 5896 64926 5897 153090 4763 399473 10156 28956 815 816 817 818 7010 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 10000 207 5525 5781 5526 5527 208 5528 5529 1493 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH 7296 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation 54386 79991 23649 7014 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation 55568 117248 10678 50614 57452 64409 79623 23275 84197 9510 6482 6484 6487 9037 4582 394263 6480 5199 7058 2218 10559 4585 339366 79147 256435 221981 113829 729920 727897 120071 79875 81794 80070 9331 2650 192134 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 5460 79923 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 3762 2782 3766 9568 3760 2785 59345 2783 3772 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome 5688 5689 5567 5568 5701 9978 5714 8945 5717 5718 83737 5687 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 6230 6232 6231 6234 6235 2197 8662 8663 140032 8894 1975 51386 3646 1968 6227 1977 6205 6229 6207 6209 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA 57472 1975 9125 1977 29883 26986 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism 3074 6548 11261 57214 3161 3038 8372 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation 6749 23054 6883 56259 6882 5982 6884 5983 10200 79733 5440 5441 1870 1639 9156 6877 5111 6879 5984 5985 29851 3115 3113 5476 8655 1781 6830 140735 27125 4068 1778 4602 4300 10459 5429 51455 23308 8832 1380 59067 55860 64837 1512 27301 81930 10673 8722 29127 3111 10121 11004 10540 4094 10538 829 5393 11340 22894 23404 54512 51013 7879 118460 4627 9646 6929 8178 6873 144455 2962 54457 5981 5436 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 23600 1384 3295 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions 286 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 5778 3558 51114 6709 5525 6710 5526 5527 9986 5528 58489 57731 5529 51104 5747 5245 2322 2668 3082 5501 1956 374 9965 2252 152831 27006 5295 10818 408 3667 1438 1445 221002 5717 5718 8660 283455 5687 57554 5688 5689 5924 5701 10048 1437 5714 22808 11221 54518 3716 5906 3815 5594 5604 5605 51125 4296 2243 2266 3560 2244 9978 161742 200734 64926 153090 4763 399473 10156 28956 815 816 817 818 7010 METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance 220074 4128 1312 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization 5594 891 64689 9133 81876 2801 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling 23118 5688 3554 5689 7186 5701 5714 3596 5778 5781 1511 5783 5604 54472 8767 79792 26095 1326 834 7335 28512 9097 57162 9978 28511 5771 29110 4615 8809 90865 7850 10392 8945 3654 5717 5718 5687 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors 7341 4286 4193 10401 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC 51293 6948 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase 80776 79902 1460 1457 5525 5526 23063 5527 5528 57551 5529 83540 91754 10783 5501 2491 9662 8655 7840 1781 22995 22897 140735 7283 891 1778 54930 25936 1453 11190 9133 27229 23354 81930 114791 80254 85378 121441 10726 55755 10806 10121 55835 7846 11004 8636 10540 5108 6232 84131 4957 64151 25909 1063 1058 79019 348235 6396 9126 10735 220134 57122 55746 NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis 10675 2239 221914 2719 9672 64132 9917 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 23118 5688 5689 5701 5714 5532 7322 997 9020 26253 10768 64170 7335 29108 5336 4582 5567 394263 5568 4585 727897 8945 170482 5717 5718 5687 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 6129 6230 6232 6141 6231 6234 6146 9669 6235 2197 8662 140032 8663 8894 51386 1968 3646 6227 6229 6156 6159 11224 6168 6169 6160 6124 1975 6130 6170 1977 6205 6207 6209 6128 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi 4854 10402 6484 6487 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling 3977 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes 55788 6947 5644 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH 2678 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 3030 51102 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors 2159 2147 2158 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts 80765 2172 28234 6555 10998 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR 3178 54845 5781 5440 5441 53834 2549 161742 200734 9965 2252 152831 27006 867 5295 5594 10818 2962 5436 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex 5525 5526 5527 5528 5529 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases 84164 51008 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors 3604 60401 23495 7132 4049 9966 10673 8741 8744 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 5361 5362 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions 11160 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB 814 815 816 10645 817 818 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition 5688 5689 5520 5701 1021 5714 10000 1870 84515 3065 8318 5111 1030 7298 207 8900 898 7027 1871 7029 4605 1876 208 5753 891 6119 6118 91750 51053 4998 5717 4999 5718 23649 1032 1031 1029 5687 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 2244 5245 54518 5906 5594 5604 5605 408 4296 815 816 2243 817 1445 818 283455 2266 FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct 7849 3214 3203 1499 3400 3975 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing 3178 54845 5440 2962 5441 5436 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses 9646 712 335 115004 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) 5520 6129 6230 6232 6141 6231 2107 6234 65110 6146 6235 23381 2197 23293 2935 26986 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors 51117 56997 48 207 51004 57107 2643 3417 6697 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling 867 5594 10818 5781 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping 2966 404672 5440 2962 5441 2071 5436 2967 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 6648 3725 1020 2801 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane 55300 5294 3631 9107 8867 4534 5783 23533 51552 5295 5287 79837 22874 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism 51293 6948 55788 686 326625 4548 5091 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection 6129 6230 6232 6141 6231 5440 6234 6146 5441 6235 79902 2197 140032 6227 2633 3840 6229 6156 6159 11224 6168 6169 6160 6124 8106 6130 6170 6396 6205 57122 6207 4927 2962 23165 6209 5436 55746 6128 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE 81622 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 23054 23373 64784 96764 10743 8204 4208 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints 545 5688 5689 7486 5701 5982 5983 5714 84515 9156 8318 9088 5984 5985 5883 3018 85236 83695 8900 3014 8924 580 8370 5932 891 6119 6118 8347 8348 63967 9133 4998 5717 4999 5718 5687 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase 5520 80776 3021 7280 3018 85236 5579 79861 3014 23063 57551 83540 91754 2010 10783 2491 140735 25936 27229 5717 81930 114791 85378 5718 10726 5687 5688 5689 11004 5701 5714 5594 6396 57122 4927 23165 55746 2801 7341 25978 64689 79643 1104 51652 255919 79902 1460 1457 5525 5526 5527 5528 5529 23175 5501 9662 8655 7840 1781 22995 22897 7283 891 1778 54930 1453 11190 9133 23354 80254 121441 246184 55755 51529 10806 10121 64682 55835 11065 7846 10393 8636 10540 5108 6232 84131 4957 64151 23592 23383 23310 25909 1063 81876 1058 79019 3930 8370 8968 348235 8347 9126 220134 10735 8348 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels 7881 81033 3755 26251 3788 3746 9196 3745 3784 3790 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination 8968 27030 6119 6118 8347 3018 8348 85236 3014 8370 3021 5932 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose 256281 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function 22808 5501 MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins 1460 1457 5501 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption 6523 6248 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 9900 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events 28964 57554 51422 5924 116444 5567 5568 10645 4900 53632 5594 814 815 816 55327 817 818 5573 5576 116443 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 3313 6627 6648 3181 6888 829 759 998 1072 27250 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression 3105 130340 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants 5525 5526 5527 5528 5529 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells 3781 55584 3779 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport 91942 57226 4707 4708 6341 4696 4701 51241 29090 4710 4519 4712 10131 55967 4714 6391 55969 440957 4728 3313 6390 1337 25994 57128 4720 4540 150274 4541 4722 1339 9997 1350 7385 4538 728568 7386 83733 51295 1345 25880 51103 617 116228 4190 192286 28958 4191 613227 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 545 7486 5982 5983 9156 5111 5984 5985 51750 5883 3018 85236 83695 8900 5531 3014 8924 580 8370 80198 146956 5932 79008 197342 79728 6119 6118 8347 5429 8348 63967 5981 57804 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 23054 5440 5441 5914 3021 3199 7528 3018 85236 3200 3014 3213 3212 3211 7703 3725 8370 3214 2146 57472 8968 5931 9125 8347 84962 8348 5436 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling 238 4192 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions 2244 54845 8546 54518 5906 5594 56829 5604 5605 57085 408 815 816 2243 1185 817 1445 818 283455 2266 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants 8322 8323 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 57554 5594 5924 815 816 817 818 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 23118 5027 7335 834 29108 835 10392 1432 330 329 8767 3654 64170 83737 10910 9447 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs 147945 28512 28511 8737 29110 4615 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis 27327 597 23405 3065 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants 2322 5781 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines 8968 5931 84193 51111 80854 23067 8370 121536 79723 2146 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis 2647 4074 408 9829 130340 8906 2799 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine 10249 389396 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway 8322 7474 8323 5158 5532 2780 83439 2782 27327 815 2785 59345 2783 1499 5145 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation 5688 5689 5336 5701 5714 5532 29760 5966 695 4794 5295 8945 5579 10768 30011 5717 6786 5718 80228 5687 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM 5440 2962 5441 5436 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 5210 5567 5568 5207 5208 5209 5528 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity 5594 4089 3065 22938 8239 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels 51305 54207 3776 50801 9424 10089 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 5594 5605 5781 7297 3716 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions 9076 64398 137075 9075 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases 30849 5594 1536 1535 1432 5880 5579 5300 50508 10811 6280 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability 57761 10000 207 208 79109 64223 1499 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 6480 10402 10559 256435 5476 10020 79053 55577 2673 5973 51005 10195 256281 81849 10825 79947 6482 4758 57171 29926 6484 197258 6487 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism 594 549 152926 10249 10295 3028 1384 26275 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 388585 10046 9978 182 51107 55851 3065 10014 3714 6868 892 142678 57534 5664 22938 1024 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase 2288 10728 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations 84197 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) 10046 8535 3596 4094 3725 80012 10538 6304 51621 3065 648 10014 7528 5931 4221 54815 22938 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 4508 4509 4519 65003 51081 6150 28957 57129 54516 51021 4539 84545 51649 122704 9553 64981 4540 10240 4541 3396 118487 51373 740 51650 51253 4538 54148 55037 9801 219927 51116 29074 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia 7027 345643 4602 647309 159989 27327 51053 10309 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes 57060 4089 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE 162466 23175 55500 55224 1120 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic 51272 57511 27128 84342 22796 9609 4121 9342 9382 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs 836 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion 9126 10735 23063 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling 10818 5781 2252 27006 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm 79902 1977 6396 9785 57122 199746 4927 7919 9984 79228 23165 84321 55746 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency 8894 1968 57761 79094 23645 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs 6396 57122 4927 11168 23165 79902 55746 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants 3815 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation 815 816 6334 817 818 29098 11280 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia 2159 2158 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape 79101 7343 54700 5440 5441 8370 3021 2071 8968 404672 2966 8347 3018 8348 85236 3014 2967 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 1021 1029 IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex 7335 57162 3654 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers 6749 84844 1728 7341 22827 3021 3065 6638 3018 85236 84181 8313 3014 3481 79843 54815 2538 6627 51639 8370 4654 6636 4656 6635 114825 6637 23613 125997 8968 23394 9646 6941 5931 6929 10320 8347 170394 8348 5105 1499 10523 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 335 3250 3240 HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC 56261 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 9978 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 6129 6230 6232 6141 6231 6234 6146 9669 6235 2197 8662 26986 140032 8663 8894 51386 1968 3646 8890 6227 1978 1967 6229 6156 6159 11224 6168 6169 6160 6124 1975 6130 6170 1977 6205 6207 6209 6128 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification 10613 5688 51422 5689 201595 5701 9978 5714 746 1603 80380 3716 53632 11160 84061 1460 1457 142678 8945 5717 5718 6185 6184 5687 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration 387 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K 5295 627 2549 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins 3897 286 6709 287 6710 6334 57731 11280 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle 28964 5295 6709 10254 9352 4646 23380 998 8239 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis 476 5350 481 483 486 6543 6546 490 491 6588 815 816 7137 10768 817 818 6786 80228 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling 55593 23586 7318 29110 7322 5300 83737 9474 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation 2244 2243 5270 2147 2266 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 84693 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis 10675 337876 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation 3082 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 891 51343 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery 6749 8178 5440 2962 5441 5436 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 7027 1871 7029 1021 898 1870 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade 5295 5336 5294 5880 5781 10630 387 80739 998 23533 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) 50833 50832 50834 50837 50836 2918 9568 50839 50838 259294 50840 353164 5726 54429 222545 80835 50835 338398 259289 259287 259286 259285 259293 259292 259290 83756 259296 259295 50831 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation 4646 81025 127534 57165 2703 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex 64682 5688 11065 5689 10393 51343 5701 5714 3021 84515 3018 85236 3014 8370 8968 8347 8348 51053 4998 5717 4999 5718 246184 51529 5687 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 7027 5594 7029 892 4221 4089 3065 1030 1024 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 5604 5781 7297 3716 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat 5440 2962 5441 5436 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 1029 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events 1432 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere 54386 6119 7486 6118 5111 7014 57804 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency 6948 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication 11232 56652 92667 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation 160 161 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis 917 5747 4651 4644 7454 10152 4627 695 1398 1793 644150 5594 3071 10093 10097 10163 10096 10810 998 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 1558 1565 4056 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants 238 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA 28512 28511 8737 29110 4615 5440 5441 170506 147945 11277 197358 5591 51728 6737 661 11128 10621 1499 115004 9447 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors 2782 2785 59345 2783 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins 7027 140735 7029 10000 207 208 8655 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 627 SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1021 1029 TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation 2107 2935 8662 51504 8663 51386 3646 27230 1978 5464 8565 6897 7407 2617 2193 1937 5717 5718 5687 5688 5689 5701 5714 7322 26986 8894 1968 8890 1967 9978 6124 25898 6130 6128 4508 4509 6129 6141 27068 6146 4519 6156 6159 65003 51081 6150 28957 51067 55176 57129 124454 51021 10352 25973 84545 57505 51649 122704 9553 6168 84164 64981 10240 4540 3396 4541 6169 118487 6160 51373 740 51650 51253 4538 54148 55037 9801 219927 1975 51116 29074 6170 10102 1977 6730 6726 6230 6232 6231 6234 9669 6235 2197 7284 140032 6227 6229 22980 11224 54516 4539 3376 9255 6205 6207 6209 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants 2322 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling 54845 22808 11221 54518 5906 5594 56829 5604 5605 4296 2243 2266 2244 5245 5501 161742 200734 8546 4763 399473 57085 408 815 816 1185 817 818 1445 283455 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 23118 3105 5781 5648 3441 79902 3439 3716 51284 23586 8767 7297 6441 30849 7335 3449 29110 3443 3605 112744 10392 6396 57122 4927 3654 23165 55746 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate 79947 57171 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 2261 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes 4199 3417 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin 5594 91 4089 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer 4089 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1482 7004 7005 204851 8463 6910 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling 3560 3558 3716 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28234 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis 10606 5471 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport 57127 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer 4089 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 5460 55211 64344 6997 2034 79923 4089 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization 5819 81607 5818 5817 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans 3908 7042 4038 4146 63923 176 3685 3913 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis 917 8322 10920 7474 2060 8301 3575 127833 10254 1956 374 867 4074 6572 29978 160 143425 408 161 338 30011 64708 50813 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression 891 MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation 10128 25996 87178 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors 5732 5733 5739 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis 1585 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 2634 2633 4072 7322 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development 201595 4644 7341 10000 523 3065 3815 427 5594 7942 1432 51606 7837 3376 1000 1638 5873 597 9255 208 23405 83439 7545 891 4286 27327 257 6490 10085 1499 1029 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling 8797 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 2252 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants 83999 22943 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS 476 23476 3554 8737 481 483 29760 2908 486 10728 10362 51317 3065 1312 3716 51284 160 161 7297 54815 10800 5336 9978 29110 695 5931 25855 2288 23028 30011 79685 8819 10280 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly 7341 8370 3021 3065 114825 23613 125997 8968 6941 5931 10320 8347 170394 3018 8348 85236 3014 5105 54815 2538 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants 11140 55914 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation 6129 6230 6232 6141 6231 6234 6146 9669 6235 2197 8662 26986 140032 8663 8894 51386 1968 3646 8890 6227 1978 1967 6229 6156 6159 11224 6168 6169 6160 6124 1975 6130 6170 1977 6205 6207 6209 6128 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes 7086 6888 2539 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 3815 29028 1956 7528 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification 51606 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol 6129 6141 10200 6146 22803 6156 6159 6168 6169 6160 6170 1453 6230 6232 6231 6234 6235 2197 5393 11340 140032 22894 23404 54512 6227 51013 6229 51602 118460 11224 9136 10171 79050 22984 25879 9790 27341 10813 51077 54555 84128 6124 11056 55813 92856 51118 6130 6205 6207 10799 79897 26354 11102 81875 6209 55781 51388 10969 6128 705 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling 5747 8633 4651 1630 5781 6586 6585 22885 1793 56963 285704 57453 7225 998 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants 2322 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding 7846 9630 1460 22803 63971 26985 2782 7280 1457 5082 79861 2785 59345 898 2783 6468 8877 10574 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes 55835 7846 8636 10540 5108 84131 4957 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 23354 80254 121441 55755 10806 10121 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 57461 1642 5982 9978 5983 5440 5441 2071 5111 5984 56949 5985 6119 404672 2966 6118 5981 5436 7874 57804 2967 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions 1808 10048 5962 1956 3685 11280 1460 5594 3897 5604 5605 160 161 286 1457 6709 287 27255 6710 6334 57731 57698 DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME 9153 54988 6783 10249 10720 54579 574537 100 5446 7363 4830 2952 10941 133688 7498 3290 341392 389396 2678 5444 27233 28234 8824 54659 1558 161823 5105 1565 55315 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 11004 6232 80776 79902 25909 5525 5526 5527 1063 5528 57551 5529 83540 1058 79019 2491 5501 8655 1781 140735 348235 1778 25936 6396 220134 57122 81930 10726 55746 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 7846 7280 79861 10574 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression 8968 79101 8347 3018 8348 85236 3014 8370 3021 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer 867 5295 1956 2549 374 11140 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants 238 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 3815 5295 CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic 51451 5520 80776 10000 3021 3065 7280 3018 85236 5579 79861 3014 23063 898 57551 3161 83540 7027 22822 1871 728642 7029 91754 2010 10783 2491 5753 140735 91750 25936 2305 27229 5717 81930 114791 85378 5718 10726 5687 5688 5689 11004 5701 5714 84515 8318 9837 51659 5594 207 8900 9978 4605 6119 6118 6396 57122 4927 51053 4998 23165 4999 55746 23649 2801 5982 7341 5983 1021 25978 64689 79643 1104 51652 1870 255919 79902 5111 1030 1460 5984 5985 1457 5525 5526 5527 5528 5529 23175 1876 5501 9662 8655 7840 1781 22995 22897 7283 891 1778 54930 84962 1453 8945 11190 9133 23354 80254 121441 246184 55755 51529 10806 10121 1029 64682 55835 11065 7846 10393 8636 10540 51343 5108 6232 84131 4957 64151 9088 23592 23383 23310 7298 25909 1063 81876 1058 79019 3930 8370 208 8968 348235 8347 9126 220134 10735 8348 5981 1032 1031 57804 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA 1977 6396 57122 4927 23165 79902 55746 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema 2161 3818 2147 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing 6421 5753 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) 5295 10818 5781 1020 627 2549 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 64682 5688 11065 5689 10393 51343 5701 5714 8900 898 5717 5718 246184 51529 5687 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 87 55742 29780 7016 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) 545 7486 5982 5983 9156 5111 80198 146956 79008 5932 5984 197342 5985 79728 6119 51750 6118 5883 5429 83695 580 5981 57804 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 23054 6319 60481 10025 133522 3021 9440 63924 892 3018 84649 85236 2167 3014 9439 11343 22822 9862 23175 1020 8370 51003 8968 8347 84962 8348 123 1024 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 867 3560 5295 1437 3558 5781 7006 29760 1438 1398 3716 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling 1956 374 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1499 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle 28964 58504 81624 116984 55114 50508 5585 5586 644150 1536 1535 55914 9826 4810 22899 8476 182 10152 2010 85440 84144 1793 613 5295 3071 4162 10160 10163 29127 128239 998 11135 5924 23592 3895 7879 57580 10811 10810 80243 55843 3930 23616 7454 55971 143872 10788 10144 27 57480 23380 57522 4983 51306 221178 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping 7474 1535 8324 3725 10811 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO 408 50937 6608 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis 4582 394263 6480 4585 256435 727897 6482 6484 6487 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions 3178 57461 84844 56259 6141 5440 5441 1993 9382 51729 3018 80273 85236 57551 79109 22938 8106 2194 9785 199746 1499 10523 7099 712 57794 8737 335 23643 22827 6993 56949 6638 10594 10236 3181 221914 23524 9672 2147 115004 6627 30849 4318 2239 51639 29959 8896 8370 51645 2719 24148 6636 6635 6637 8968 9646 8347 8348 85313 815 816 817 10084 2962 818 11051 5436 64223 51585 10015 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation 23118 7335 7186 10392 28512 9097 28511 8767 3654 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer 3002 1639 3065 5551 5594 29851 7297 53335 5573 9978 57674 3725 4627 597 7170 3092 1937 6801 5295 891 238 10818 3667 22872 2305 4193 9648 4869 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases 5594 1432 3725 5528 4208 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription 7004 7005 8463 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle 101059918 87 5361 81624 3930 55114 2010 23592 5295 4162 29984 79180 7879 29127 144402 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling 5747 1630 1793 22885 998 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste 50833 50832 50834 50837 50836 50839 50838 50840 2782 5726 54429 80835 255022 259289 259287 259286 259285 259293 259292 259290 83756 259296 259295 54795 50831 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 30061 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements 113835 79862 7700 285676 8370 3021 3065 7581 197320 8968 5931 8347 3018 8348 85236 22880 3014 25799 84911 54815 54737 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation 54386 6996 8347 4913 3018 8348 85236 3014 8370 7014 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors 6129 6141 2107 65110 6146 9355 4440 6585 3199 1287 2935 10486 6156 6159 1630 6168 6169 6160 387 51466 6170 8861 5717 5718 998 5687 5688 5689 5701 6230 6232 5714 6231 5532 6234 6235 6586 2197 26986 140032 6227 6229 5576 11224 5567 5568 9978 6124 9495 6130 27 6205 6207 23380 57522 6209 6128 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway 51071 55276 7086 6120 23729 6888 2539 TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling 23118 90268 7186 84888 7124 8439 56928 8737 29110 7322 6868 7132 330 142678 329 81858 7332 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 6749 6883 6882 6884 5440 5441 2071 6877 6879 6830 27125 9646 404672 4300 2966 8178 6873 2962 54457 5436 2967 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A 64682 11065 10393 246184 51529 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 23380 57522 998 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora 378884 5507 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 388585 10046 2324 22938 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions 6443 6640 6442 87 6444 3685 6645 1837 8082 51399 780 54221 3908 3691 9672 3913 6641 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation 917 5747 4651 4644 7454 10152 4627 4771 695 1398 1793 644150 5594 3071 10093 10097 10163 10096 10810 1072 998 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 23118 5688 917 7335 5689 5701 5714 7322 997 5295 8945 8767 5717 3115 5718 3113 5687 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs 4627 4628 387 1072 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions 221935 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 8535 3725 80012 3065 648 10014 2146 1958 5594 5931 6615 28956 23028 64223 54815 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling 867 5594 10818 5781 9965 152831 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors 1144 1141 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling 6319 80820 1071 55818 2172 344 2194 341 348 27327 221656 54659 8204 23028 5105 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs 5906 5594 5604 1432 10818 5605 1398 6014 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 56261 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) 545 7486 5982 5983 9156 5932 5984 5985 6119 6118 5883 83695 580 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria 140735 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis 5594 26276 57674 51606 11151 7879 6421 4843 1511 2023 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation 7186 23586 3449 29110 3443 3441 3439 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin 9126 10735 23063 23383 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility 5906 3908 5747 3082 85440 2549 1398 3913 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins 2239 335 336 54884 337 2719 154807 344 345 348 338 221914 9672 1208 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle 83733 4190 4191 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins 9583 377841 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle 5924 58504 81624 116984 708 5585 5586 3895 23002 4649 57580 55914 80243 9826 29941 9828 22899 3930 2040 387 84317 613 70 143872 55852 5295 10144 4162 10160 5825 57522 55831 4983 29127 537 128239 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 1460 8535 55193 1457 26053 80012 23429 648 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs 29941 367 4627 8370 387 3021 5585 5586 8968 8347 3018 8348 85236 23028 4628 3014 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization 63924 161247 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen 51706 760 51700 759 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling 5295 2316 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 8797 120425 481 5680 5781 483 9123 6693 6403 51744 914 5670 23759 5671 5673 2993 5669 3897 338 5197 4312 9672 2147 23428 9056 23657 3684 3685 1048 5295 4072 8832 4267 7010 5175 51378 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival 3654 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 5688 5689 571 1728 5701 9978 5714 23657 374 7296 7086 4199 8945 84181 6888 2539 5717 5718 3417 5687 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins 7341 6396 57122 4193 5371 4927 23165 79902 55746 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response 23586 4939 6041 2316 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium 23265 8766 5311 SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection 3178 23193 6230 7341 6232 6231 25978 9360 6234 79643 64398 6235 51652 2197 140032 51284 23586 6227 6229 5479 6482 6441 83737 6484 6487 10465 30849 834 29108 6480 29110 256435 3437 6205 6207 6209 4869 4089 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 5688 5689 5701 9978 5714 8945 5717 5718 5687 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism 3074 10678 11046 10402 9435 176 9331 6482 2799 6484 6487 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport 55244 115286 146802 5002 6248 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 5294 2322 5880 5781 3082 627 1956 2549 374 9965 2252 152831 27006 23533 6801 3815 5295 10818 3667 8660 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs 10000 51552 207 7879 22878 79090 54453 81876 2664 23682 201627 5872 6764 5873 414918 9909 208 79961 51399 60684 122553 7109 84079 9367 5878 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 6615 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression 2908 2034 5753 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases 26050 22865 8499 84631 94030 5789 84189 8541 8497 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition 51451 5520 3161 22822 728642 9662 8655 7840 1781 22995 22897 7283 891 1778 91750 54930 84962 2305 1453 8945 11190 9133 27229 23354 114791 5717 80254 85378 5718 121441 55755 10806 10121 5687 5688 55835 7846 5689 8636 10540 5701 51343 5108 5714 84131 4957 9088 8900 1063 9978 4605 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters 64216 7978 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass 1642 5982 9978 5983 5111 5984 25898 5985 6119 7320 7318 6118 10459 5429 51455 9100 5981 57804 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors 1144 55584 1141 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions 7099 10025 23643 3441 9440 3439 3716 51284 23586 4939 892 112950 7297 221914 9439 9672 9978 2239 3449 9862 80306 3443 2719 51003 1024 SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes 378807 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement 5688 5689 5701 5714 1793 3716 329 1009 7297 5717 5718 1499 998 5687 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling 1975 84335 1978 1977 28956 64223 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling 834 5771 29110 5778 5781 26095 8809 5783 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 5688 5689 7004 10046 5701 7005 182 5714 463 8463 83439 4193 6046 4089 5717 5718 1499 22938 5687 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 5688 5689 5567 5568 5701 5714 3725 5896 5897 27327 5717 5596 5718 2118 998 5687 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1460 1407 1457 1453 1020 5501 UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle 57407 384 435 162417 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 1836 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones 3626 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer 5294 10000 5781 627 3815 207 79109 2322 5880 3082 1956 2549 208 374 9965 2252 152831 27006 6801 23533 5295 84335 10818 7249 3667 4193 64223 8660 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly 1058 79019 8607 51773 2491 8370 54069 5931 8347 3018 8348 85236 3014 4869 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE 254531 50487 11145 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) 5688 5689 5701 5714 5532 8945 5579 5966 5717 5718 4794 5687 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG 114971 9489 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 1558 1565 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity METHYLATION%REACTOME%R-HSA-156581.6 Methylation 191 4144 4548 57412 1312 51504 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation 5906 1398 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 1029 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion 9630 2181 2864 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein 23193 6480 201595 746 256435 51114 1603 84061 11282 55741 51125 11320 4249 51304 6482 6185 6484 6487 6184 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation 6687 3313 4508 4540 4541 27166 4722 4967 3028 7385 56652 3418 384 9361 51116 4712 10440 4191 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease 5440 5441 2261 2549 613 2252 27006 11160 26127 5295 10818 7750 2962 5436 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade 23118 7099 7186 8737 23643 5781 7322 5594 5604 1432 330 329 8767 5528 1326 4208 7335 28512 9097 28511 29110 3725 10392 8945 3654 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer 5295 5594 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 7846 7280 10574 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 2782 2771 2785 59345 2783 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 374 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 1956 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) 4615 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation 11004 10540 829 1639 160 161 7879 3115 3113 5476 8655 130340 5641 1781 140735 1778 6396 22872 55860 64837 1512 81930 8722 29127 3111 10121 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus 79837 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins 103 104 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor 2782 2785 59345 2783 5739 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle 28964 5924 101059918 58504 81624 116984 55114 3895 23002 644150 398 4296 7879 23048 57580 144402 80243 9826 22899 8476 3930 7454 85440 2040 613 143872 10788 5295 10160 57480 23380 57522 4983 29127 128239 998 51306 11135 221178 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants 1956 11140 55914 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction 476 5350 481 483 4880 486 54207 3776 50801 6543 6546 490 11280 491 6588 6334 7137 10768 23630 29098 6786 30818 80228 3784 51305 6910 9424 10089 1482 815 816 817 204851 818 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence 64682 50488 9448 11065 10393 51343 8535 1021 80012 3009 3007 1870 3006 3021 648 4217 25842 1030 5594 1432 3018 85236 8900 3014 898 7014 7027 54386 1871 7029 3725 8370 2146 8968 5931 8091 8347 27327 8348 4193 1032 246184 51529 1031 3576 1029 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange 545 7486 5982 5983 9156 5932 5984 5985 79728 6119 6118 5883 83695 580 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane 30849 55300 DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE 4548 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins 93343 7251 51271 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 1021 1029 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 4854 51107 55851 5664 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript 6749 2966 404672 8178 5440 2962 5441 2071 5436 2967 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers 6749 84844 1728 7341 22827 3021 3065 6638 3018 85236 84181 8313 3014 3481 53335 79843 55274 54815 2538 6627 51639 8370 4654 6636 4656 6635 114825 6637 23613 125997 8968 23394 9646 6941 5931 6929 10320 8347 55193 170394 8348 5105 1499 10523 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK 51422 51719 7249 28956 64223 92335 81617 53632 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 5688 5689 5701 5714 8370 3021 8968 6929 4602 8347 3018 8348 85236 3014 8861 5717 5718 2623 83737 5687 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage 272 100 161823 151531 7371 271 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI 5984 5985 6119 6118 10459 5982 5983 51455 5981 5111 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus 10000 207 208 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling 5567 5568 814 815 816 10645 10768 817 818 5573 5136 5576 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 6319 2194 8204 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis 83930 9256 10948 231 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway 2244 5688 7099 5689 5701 3105 5714 23643 4615 695 6280 2243 5717 6271 5718 9554 55176 2266 5687 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol 6396 57122 4927 23165 79902 55746 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 2322 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 7184 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling 23118 5688 7335 5689 5336 5701 5714 5532 3725 7322 7006 997 695 7294 5295 5594 8945 2206 10768 5717 5718 3702 5687 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 23118 7099 7186 23643 5594 5604 1432 8767 2243 5528 1326 4208 2266 2244 7335 28512 9097 57162 28511 4615 3725 695 6280 10392 51295 8945 3654 6271 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism 10675 3074 337876 8372 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic 113220 3833 11004 5049 10540 23299 636 10749 22836 829 1639 9342 9382 4121 81876 9554 23647 339122 6293 51272 54732 57511 27128 55850 84342 122830 22796 84316 51014 9609 60561 11014 8655 1781 140735 4074 9367 1778 23046 55582 55860 64837 9648 81930 29127 10121 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease 6888 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF 5295 7058 1286 5340 5781 1293 7060 1398 1287 5327 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle 22999 10815 8499 9256 8541 8497 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding 5525 5526 5527 5528 5529 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling 146433 3588 7297 163702 5657 282618 836 3716 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation 22944 221143 79091 399818 196483 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane 7478 5525 23401 5526 5527 5528 5529 1499 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 25979 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling 5140 208 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism 5567 5568 335 8720 336 337 1071 55911 344 160 341 345 161 348 338 4547 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN 627 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 2966 404672 5440 2962 5441 2071 5436 2967 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing 6129 6141 10200 6146 3028 51504 22803 6156 6159 6168 6169 6160 51335 6170 1453 6230 6232 6231 6234 6235 2197 5393 11340 140032 22894 23404 54512 6227 54931 51013 9692 6229 60528 51602 118460 11224 9136 10171 79050 22984 25879 9790 27341 10813 55226 51077 54555 84128 6124 11056 55813 55505 92856 51118 1736 6130 6205 6207 10799 79897 26354 11102 81875 6209 55781 51388 10969 6128 705 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system 8968 5547 8347 3018 8348 85236 3014 708 2161 8370 3021 3818 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 2159 2147 2158 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism 7421 5641 AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy 140735 7335 1778 8655 1781 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections 476 23118 11218 23193 201595 3105 10000 481 746 483 51114 486 6732 5648 1603 3065 1312 5479 54815 10800 834 29108 5336 695 30011 23028 3554 8737 10362 51317 207 83737 10465 9978 6396 57122 4927 23165 4869 4089 55746 10280 3178 23476 7341 25978 9360 79643 29760 2908 51652 79902 23586 160 161 25855 6230 6232 6231 5781 6234 10728 64398 6235 3441 2197 7284 3439 3716 140032 51284 26276 6227 51125 65082 6229 8767 4249 7297 221914 6482 9672 6441 6484 6487 30849 7335 64601 6480 2239 3449 29110 256435 196527 3443 208 2719 6636 6635 6637 3605 84061 112744 5931 10392 11282 3437 55741 11320 6205 2288 6207 55823 51304 3654 79685 6209 8819 8487 6185 23479 6184 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors 8535 7341 80012 8204 10401 3622 7703 4869 648 1487 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions 5747 10326 5781 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 5393 11340 26986 57472 22894 23404 1975 54512 9125 167227 1977 51013 57819 118460 29883 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors 5207 5528 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding 4913 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 6873 2962 54457 5436 2967 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins 5295 7750 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 79101 5440 5441 8370 3021 3065 8968 10514 5931 8347 3018 8348 85236 3014 54815 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 3762 2782 3766 9568 3760 2785 59345 2783 3772 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock 23054 5688 5689 64784 5701 96764 10743 5714 1460 1374 23373 7942 1407 1457 4208 9978 1020 5501 56938 1453 8945 8204 5717 5718 5687 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 231 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 1584 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors 3762 2782 3766 9568 3760 2771 2785 59345 2783 3772 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation 5136 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor 25994 2034 405 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine 103 104 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen 2244 2243 2266 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation 5300 79837 3622 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways 2060 127833 7322 1511 7296 5594 9900 26276 2634 5604 5605 2633 51606 11151 7879 4843 57674 10254 6421 867 4072 30011 928 2023 1499 10015 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN 5688 5689 5701 5714 81847 8313 5717 5718 5687 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD 10675 2239 221914 2719 9672 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance 7486 5982 5983 79075 79991 23243 5440 5441 5537 80119 3021 5111 5984 5985 51750 3018 85236 8900 3014 7014 54386 546 10856 8607 8370 55505 1736 6119 6118 8347 8348 5981 5436 23649 57804 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling 867 5295 27 2322 10000 207 5781 1445 10019 208 5795 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD 594 DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 8720 7184 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia 5688 25994 5689 5701 9978 5714 7322 2034 405 64344 84962 8994 5717 5718 5687 DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 79947 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control 5688 5689 6129 5701 6230 6232 5714 6141 6231 7322 6234 6146 6235 2197 140032 6227 6229 6156 6159 22980 11224 9978 6168 84164 6169 6160 6124 25898 6130 6170 6205 6207 5717 6209 5718 6128 5687 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function 1006 1009 64403 1499 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling 11074 3609 3105 7341 6041 79902 8662 8663 51386 2634 3646 23586 7318 4939 2633 3840 3608 5525 388646 5371 3115 3113 8877 834 51447 1958 1977 103 6230 6232 6231 5781 6234 6235 3441 2197 3439 3716 140032 8894 5594 1968 6227 81603 6229 55223 7297 3430 3664 3669 3449 5771 5300 3443 3663 2316 10379 8672 3437 10475 6396 2176 2187 6205 815 57122 6207 816 4927 817 4502 818 6737 23165 6209 4869 55746 79097 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal 4255 84164 51008 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions 3178 6230 6232 6231 9360 6234 64398 6235 2197 140032 51284 23586 6227 6229 5479 6441 83737 10465 834 29108 29110 3437 6205 6207 6209 4869 4089 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog 5688 5689 5701 5714 55733 6868 374654 5573 9742 5576 83737 6608 80199 51098 55764 5567 5568 9978 84447 50937 22873 408 8945 5717 5718 5687 CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects 10846 27345 5136 50940 3779 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection 5027 834 29108 5025 79792 719 1511 10910 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly 5688 5689 5701 51371 5714 5715 5716 5717 5718 5687 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors 335 3250 5648 3240 6280 2495 348 338 4481 286133 922 117156 7184 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase 64682 5688 11065 5689 10393 51343 5701 5982 5983 5714 10000 84515 8318 9837 5111 51659 5984 5985 207 8900 23063 898 7027 7029 9978 208 5753 6119 6118 91750 9126 10735 51053 4998 5717 4999 5981 5718 23649 246184 51529 57804 5687 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling 9978 5781 8945 5618 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling 5295 57761 5294 10000 207 208 1326 79109 64223 9020 23533 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events 891 91750 4605 2305 9133 1063 9088 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism 144193 131669 57571 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants 3815 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases 367 55611 23586 3018 85236 9100 9986 8295 23326 9097 81847 8607 90865 408 401447 728386 392188 219333 5717 10868 5718 10869 51651 91833 5687 8239 29761 5688 57646 7419 5689 7186 84101 5701 100287327 23358 8737 5714 57695 5423 7416 7046 330 329 8900 8313 9958 10254 8347 8348 4193 63967 4089 7874 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS 4582 394263 4585 727897 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events 5140 208 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis 20 335 5825 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation 5294 51706 2771 5583 6403 2151 9630 3920 8525 2782 5028 5579 2785 3481 139189 59345 7273 2783 150 11343 5747 5336 5880 3082 747 1607 387 1398 23533 5295 408 928 1445 7225 998 87 335 7044 7123 5340 5781 29789 350 94121 3959 5660 23052 54518 9948 813 7873 5906 374354 3479 5594 1432 207 2243 2147 1072 2266 7042 2244 967 10630 80739 2316 1675 5175 5005 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) 64682 11065 10393 51343 1021 3725 8370 3021 1030 5594 8968 8347 3018 8348 85236 8900 3014 1032 246184 51529 1031 1029 3576 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders 814 3065 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines 29110 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 6888 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins 3082 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 867 5295 1956 2549 11140 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane 55300 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling 8894 1968 3609 7341 5771 103 2176 2187 3608 5525 4869 8877 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function 80149 1499 28513 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling 4316 5747 4318 10000 2771 208 1956 374 1903 6801 5295 5594 858 2782 207 2785 59345 2783 8877 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL 6997 4838 91 199699 7044 9350 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG 4548 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing 3178 6631 84844 10929 57794 10772 5440 5441 22827 55660 22803 6638 10236 3181 23524 6627 5930 51639 6636 8106 6635 6637 9785 199746 7919 9984 2962 11051 79228 84321 5436 51585 10523 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport 133418 9123 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL 1432 338 5525 5781 5526 5527 5175 5528 5529 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing 3178 57461 84844 56259 9360 5440 5441 51729 22938 9785 199746 7919 10523 84081 6631 10929 11066 57794 10772 51691 84950 8899 22827 9129 151903 55660 143884 23759 5411 56949 23398 63932 60625 6638 79622 51634 10594 57819 8559 10236 58509 51759 3181 11017 23524 10465 6627 51639 8896 51645 24148 6636 6635 6637 85313 10084 2962 5436 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase 4128 1312 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 6443 3908 6640 6442 6444 6645 1837 8082 3913 54221 6641 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells 3908 3913 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants 2322 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 5423 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate 316 8566 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 2252 27006 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade 23118 7335 7186 28512 9097 57162 28511 4615 3725 5594 10392 51295 5604 1432 8945 8767 3654 5528 1326 4208 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling 5295 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 8370 8347 64421 3018 8348 79840 85236 27343 3014 8924 51567 580 5591 7518 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 7879 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 6618 6617 5440 5441 55290 51728 661 11128 10621 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 594 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism 326625 4548 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins 6996 7486 8535 7341 7508 80012 79902 648 6396 9126 197370 10735 57122 79677 5371 4927 8924 54780 23165 7703 55746 7518 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease 10025 5440 5441 3065 9440 644150 2966 1535 892 3018 85236 11168 5479 57551 9439 54815 2967 5747 5336 10152 695 140735 3071 9076 30011 10163 928 5717 5718 1499 10523 5687 5688 3554 5689 712 5701 57794 5714 127833 335 22827 6993 26986 56949 9900 6638 1432 10594 207 10236 5573 5576 23524 83737 115004 10465 11314 5567 5568 7301 9978 5119 10313 51639 29959 8896 51645 6124 24148 4061 8672 6130 9646 8178 4072 6396 85313 815 6873 816 9532 57122 817 10084 4927 818 11051 2962 54457 23165 4089 10294 5436 55746 51585 7518 6128 10280 10015 23476 6749 57461 93343 84844 6883 6129 56259 6882 6884 6141 7251 22924 25978 9360 51271 79643 6146 29760 1104 1993 51652 79902 6877 6879 9382 1800 4836 51729 23586 2634 7318 4939 160 2633 161 3840 80273 6156 6159 6168 6169 6160 5295 6170 6230 6232 6231 5781 6234 64398 6235 3441 2197 7284 3439 3716 140032 7296 51284 26276 6227 51125 65082 112950 6229 8767 4249 7297 221914 6482 9672 2147 6441 6484 6487 30849 7335 64601 6480 2239 3449 29110 256435 196527 3443 208 2719 6636 6635 6637 3605 84061 112744 10392 11282 3437 84313 55741 11320 6205 6207 55823 51304 3654 6209 8487 6185 23479 6184 476 23118 11218 23193 201595 3105 10000 481 746 2771 483 51114 486 6732 5648 1603 1312 2782 2785 59345 2783 10910 2781 22938 10800 917 5027 834 29108 3725 6421 130340 1398 1793 867 2194 9785 5878 199746 23028 998 7099 7474 8324 8737 23643 7322 10362 51317 5594 5604 5605 51606 11151 7879 4843 3181 6627 57674 4627 2678 55236 4869 64223 3178 2060 4651 4644 7341 2908 1460 1457 10768 5371 79792 79109 80306 5025 719 5501 1956 8655 8106 1781 1778 1977 25855 8945 2023 10728 1511 6868 10093 10097 10096 10811 10810 11224 4318 10254 9862 7454 8370 2071 51003 2146 8968 5931 404672 8347 8348 2288 79685 8819 1024 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses 51284 834 29108 23586 3437 29110 9360 5479 6441 83737 10465 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA 1977 6396 57122 4927 23165 79902 55746 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate 11046 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions 7251 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 10675 2239 221914 2719 9672 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT 220074 4128 1312 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer 7046 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy 51422 100188893 7419 93343 7251 25978 7322 51271 79643 51652 7416 9927 53632 1460 3920 1457 115201 60673 7332 9776 64422 84971 30849 7335 11345 29110 2034 8655 1781 140735 11337 1778 7249 28956 64223 123 9474 55669 54543 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins 140881 140850 417 503618 5645 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 25888 6636 6635 6637 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import 3313 51025 100188893 10245 9512 400916 150274 7416 10651 29090 80273 617 516 10440 4714 51287 54543 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 10920 5049 23299 636 10000 5648 22836 10113 6709 4646 23647 917 339122 6293 54732 55850 122830 84316 51014 60561 11014 7164 374 9026 130340 8546 6280 388552 2495 6272 140735 867 2647 55330 54885 408 7249 23046 22872 9829 55582 5878 922 30011 64837 81930 29127 113220 8322 3833 7474 11004 335 127833 10749 829 8867 6517 338 348 207 7879 9882 3630 4253 3575 273 79058 4627 9847 3240 3092 2799 4074 6396 9648 2801 51422 93343 2060 4644 9117 7251 11196 25978 51271 23243 64689 79643 5537 51652 10960 1639 9342 9382 51552 53632 160 161 287 6710 57731 9554 1956 8655 1781 1778 1453 4481 286133 55860 117156 7184 10121 8301 10540 8906 23265 10093 286 10097 8766 10096 23048 22878 4121 79090 54453 81876 2664 57465 23163 23682 51272 11345 57511 27128 201627 84342 5872 10254 6764 22796 5873 9609 9230 3250 414918 54662 9909 208 79961 81025 127534 26000 51399 57165 2703 60684 122553 7109 84079 9367 11337 6572 29978 84313 143425 64708 50813 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression 6929 27327 5914 4089 4654 4656 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism 272 10606 9615 7498 5471 9583 6240 7371 151531 7296 100 7298 4830 4833 205 10201 161823 102157402 377841 271 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling 5688 5689 5701 5714 8945 5717 5718 9020 5687 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres 54386 7486 5982 5983 79075 10856 79991 23243 8607 5537 80119 5111 55505 5984 5985 6119 1736 51750 6118 8900 5981 23649 7014 57804 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 84061 201595 142678 746 1603 6185 80380 3716 6184 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers 80024 6543 6546 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis 54386 7486 5982 5983 79075 79991 5111 5984 5985 6119 6118 5981 23649 7014 57804 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH 5984 5985 25898 6119 6118 5982 5429 5983 5981 5111 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion 93343 7251 51271 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 5648 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling 4508 4509 516 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade 23118 7099 7186 23643 51284 5594 5604 1432 8767 5528 1326 4208 7335 28512 9097 57162 28511 4615 3725 80231 3663 10392 51295 8945 3654 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing 834 79792 1511 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions 87 3691 3685 9672 51399 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane 55835 7846 8636 10540 5108 80776 84131 4957 347240 132320 8766 26123 54806 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 23354 80254 121441 55755 10806 10121 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 57761 10000 1536 1535 1432 207 5579 10768 79109 10810 8877 5747 5567 5568 10152 9047 387 208 3685 1398 1793 5295 3071 2324 10163 3791 64223 1499 998 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters 6508 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS 81490 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation 5594 5336 3725 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins 7341 6396 57122 4927 23165 79902 55746 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling 867 5594 10818 5781 2252 27006 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins 6709 4137 5339 836 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases 2542 378884 5507 2538 2548 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production 5567 5568 2782 2771 2785 59345 5573 2783 5576 2781 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse 4627 4628 387 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 834 8738 55367 835 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 10574 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 53335 55274 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling 10046 182 22938 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling 10312 50617 51606 245972 9296 523 537 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation 57554 815 816 817 4900 818 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 2673 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events 30849 2239 25978 79643 221914 51652 2719 9672 23479 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors 9390 8566 2643 48 1208 2350 316 4522 6948 6947 80704 51293 5168 79717 55229 2194 4548 51248 6573 9962 79581 6697 9963 51117 56997 55788 335 336 686 337 8884 5091 10840 32 57107 154807 344 345 338 348 207 51004 326625 221914 9672 5644 83594 2239 54884 2719 23057 113235 1528 92014 3417 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway 23118 7335 834 10392 1432 330 329 8767 3654 835 64170 83737 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB 57761 208 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines 5688 5689 1728 5701 5714 79814 6723 4947 5717 5718 262 5687 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption 27159 6523 278 1208 8513 8544 2980 6248 G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase 1871 8900 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins 5264 3295 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly 80776 10309 345643 647309 159989 7027 9662 8655 7840 1781 22995 22897 140735 7283 1778 4602 54930 27327 1453 11190 23354 80254 121441 55755 10806 10121 55835 7846 8636 10540 5108 84131 4957 112752 28981 79989 255758 347240 23265 84100 2847 132320 8766 5311 55212 26123 9742 54806 6608 51098 55764 51053 RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events 611 145226 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin 60509 7846 284076 7280 123624 23093 22846 23287 79805 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease 11160 26127 5295 10818 7750 2549 613 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis 1585 1584 3290 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 2160 2159 2158 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 27006 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking 51070 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 201595 1000 10085 7837 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events 57127 84061 152519 563 123606 57380 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs 60481 9524 2181 79071 9200 64834 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs 23163 11345 11337 7249 5878 8766 7879 9230 54662 26000 57465 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding 9965 152831 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus 4854 142678 182 51107 55851 1956 57534 5664 3714 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 26063 51179 5264 26061 23600 1384 3295 10478 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation 4967 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly 25994 1337 1339 9997 1350 6341 51241 1345 29090 116228 192286 28958 55969 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression 22894 8894 23404 54512 1968 167227 51013 118460 5393 11340 3576 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 11140 55914 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins 8535 7341 6396 80012 57122 4927 51602 23165 79902 7703 648 55746 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs 8968 8347 3018 8348 85236 27327 5440 3014 5441 8370 3021 5436 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism 1428 501 51268 89874 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex 23118 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation 3009 3007 3006 836 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction 27127 545 10734 27030 3021 3018 85236 3014 378807 7014 54386 10630 8370 79923 5932 5460 8968 6119 6118 8347 9126 7784 10735 8348 9139 928 9985 23353 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling 56896 1400 1808 5361 1020 5362 1809 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine 54988 10249 341392 389396 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 80339 84649 11343 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) 30061 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants 5525 5526 5527 5528 5529 1499 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 26275 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding 2782 2900 2785 59345 2901 2783 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling 83737 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction 611 145226 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins 611 94233 23596 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle 64682 5688 11065 5689 10393 51343 5701 5714 891 8945 8900 5717 5718 246184 51529 5687 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome 23118 7099 7335 7186 28512 9097 57162 28511 23643 4615 3725 5594 51284 10392 51295 5604 1432 8945 8767 3654 5528 1326 4208 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib 11140 55914 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex 23118 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity 708 2161 3818 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors 25946 51230 54971 10000 207 5457 208 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK 5924 9828 22899 445328 57580 9826 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking 4646 81025 127534 57165 2703 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER 10038 1642 5982 9978 5983 2071 5111 5984 5985 6119 404672 2966 6118 5981 57804 2967 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints 545 25946 7486 5982 5983 80776 79902 9156 5984 5985 5883 3018 85236 5525 83695 3014 5526 580 5527 898 5528 57551 5529 83540 51230 5501 2491 8655 1781 140735 891 1778 25936 8945 9133 81930 5717 5718 10726 246184 51529 5687 64682 5688 11065 5689 10393 11004 5701 6232 5714 64326 84515 8318 9088 1432 25909 8900 8924 1063 1058 79019 9978 57060 8370 5932 6119 6118 348235 8347 6396 8348 220134 57122 4193 63967 4998 4999 55746 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription 79101 7343 54700 5440 5441 8370 3021 2071 3065 8968 5931 404672 2966 8347 3018 8348 85236 3014 54815 2967 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors 150 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer 9978 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway 5567 5568 814 815 816 10645 817 818 5573 5136 5576 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion 26276 11151 7879 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic 113220 3833 54732 11004 55850 51014 10749 60561 11014 23046 55582 64837 81930 81876 29127 9554 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology 23054 28964 10025 133522 8912 2107 5440 65110 9355 5441 4440 3021 6585 3065 3199 9440 1287 2935 64344 427 23129 892 6709 3018 1286 85236 1293 2167 3014 9439 54815 7837 9826 5747 5361 79923 51466 6615 30011 5105 5717 5718 134701 1499 5687 5688 5689 2043 5701 7124 8535 10683 5714 3596 4094 343930 7044 80012 10538 6348 6304 51621 648 10014 7528 26986 4838 1432 199699 207 9967 4208 5576 5567 5568 9978 55897 6899 597 6124 6910 1482 6130 6929 2672 353323 54474 81851 4089 3875 5436 3891 353332 121391 6128 2313 5621 100505753 8911 51350 6129 7004 57211 85294 6141 3849 23090 4155 6146 3850 3851 3856 3857 2044 5376 22885 8463 2657 11280 3866 2050 3868 2049 2047 3897 56963 160 10486 220164 161 287 6156 6710 6334 6159 285704 57453 7703 57731 57698 5649 3913 6168 182 3172 2668 6169 6160 3207 10736 2138 3237 3214 3203 3400 3975 3908 7849 5295 6170 10818 27327 8861 1029 10048 6230 6232 6231 5781 6234 6235 2197 140032 7942 6227 112950 6229 9037 5873 1638 9255 208 9495 4286 257 6205 6207 6209 201595 96764 10000 6732 523 22938 7027 7029 10046 3725 2034 2549 387 374 1796 50937 1793 2252 5460 83439 7545 4602 7225 7480 8660 998 5532 23414 2645 4185 55203 8745 10368 5594 688 5604 6517 5605 51606 3595 5362 5365 1809 1072 8482 56896 1400 1808 1000 3630 4917 1013 1002 4627 1496 57472 9125 29883 64065 4651 4644 7341 5493 643394 25818 353134 43847 5914 353133 353135 353137 353139 199834 353141 1460 5730 353140 353143 353142 643414 142910 1457 5317 643418 3713 8633 1630 80306 5962 1956 23405 8106 100288687 503835 55211 1975 891 678 284355 1977 84962 10765 8502 1832 3170 6586 4760 3651 390874 256297 389692 3815 4821 10093 286 27255 10097 10096 3200 3213 3212 3211 5664 11224 91 3376 4318 9862 51107 9350 268 1020 8370 55851 3685 4654 4656 51003 2146 6997 8968 5931 27 8347 4221 8348 6490 4628 23380 10085 57522 1024 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 3815 5295 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis 23054 7124 96764 10025 133522 9862 23090 80306 3065 9440 51003 688 5931 6517 892 112950 9967 2167 5105 4089 9439 7480 54815 1024 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport 113220 3833 11004 5049 10540 23299 636 10749 829 1639 81876 9554 54732 55850 51014 60561 11014 8655 1781 140735 1778 23046 55582 55860 64837 81930 29127 10121 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis 51171 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis 5781 6543 6546 490 491 1432 2782 338 5525 2785 4843 5526 59345 5527 10846 5528 27345 2783 5529 6786 5136 80228 50940 3779 5027 5025 5175 7225 5739 DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants 238 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion 9630 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression 1000 201595 4644 5873 1638 597 523 208 23405 3065 427 83439 891 1432 51606 27327 6490 10085 7837 1499 1029 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis 2673 5236 79947 10020 130589 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters 83439 8313 1499 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated 5525 5526 5527 5528 5529 1499 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence 1021 1029 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease 867 5295 2322 5781 7750 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation 1432 4644 5873 1638 6490 208 1499 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT 4627 4628 387 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids 3030 51102 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains 917 1445 26191 3115 3113 5795 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed 7341 29843 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 3065 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway 10046 4854 3065 10014 22938 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome 5688 5689 5567 5568 5701 9978 5714 8945 5717 5718 5687 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants 2322 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation 9965 152831 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 51422 2771 32 3790 9630 5906 47 2782 5207 2785 10768 3745 59345 5573 5528 2783 5576 150 5567 26251 5568 3630 9495 7086 2194 2181 2864 79602 6888 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation 207 4836 6697 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 9355 391211 81285 504190 256892 390058 26532 390059 26658 26539 26538 341276 343172 390063 390064 390066 79541 282763 283694 283297 219429 126370 390151 120787 442191 390167 390326 144124 144125 283159 403253 401993 391107 81797 81399 26696 120586 8861 120065 120066 81696 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels 3762 3766 9568 54207 3776 50801 3790 7881 3782 81033 3755 3788 2782 3746 9196 2785 3745 59345 27345 2783 3784 3779 3781 51305 26251 9424 10089 3760 3772 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters 7781 7780 283375 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening 8968 8347 3018 8348 85236 7343 3014 8370 3021 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer 7046 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade 30849 57761 2322 5781 208 2549 9965 2252 152831 27006 5295 3479 10818 3667 5140 3481 8660 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 388585 10046 9978 182 51107 55851 3065 10014 3714 6868 892 142678 57534 5664 22938 1024 CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT 5532 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 4056 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 2252 27006 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling 27 10486 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency 686 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors 9170 1902 9294 57121 1903 23566 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 7335 57162 3654 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs 5886 5887 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis 7257 23405 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) 9056 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling 10818 5781 27006 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS 9037 9510 5199 7058 339366 221981 79875 81794 80070 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events 23193 6480 201595 7341 746 256435 51114 196527 6732 1603 84061 11282 55741 51125 11320 4249 51304 6482 6185 6484 6487 6184 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation 55854 4733 2107 2158 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 8968 8347 3018 8348 85236 22880 3014 8370 3021 54737 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 151531 7371 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers 57761 5294 10000 3065 1460 1457 5525 5371 10768 5526 5527 5528 5529 5136 79109 54815 2322 81847 4615 3725 5880 2444 3082 10645 2549 1956 90865 374 8870 9965 2252 152831 27006 23533 6801 1958 5295 23239 84335 10818 6615 7249 3667 27327 23028 5717 5718 8660 5687 5688 5689 5701 8535 5714 5781 80012 627 648 10014 3815 5594 23608 207 5573 5576 80243 5567 5568 3630 208 2146 5931 814 28956 815 4193 816 817 818 3654 79837 64223 7874 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death 8737 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 1956 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors 8370 3021 3065 23613 8968 6941 5931 10320 8347 3018 8348 85236 3014 5105 54815 2538 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion 51335 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase 23630 3784 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane 23118 7335 7186 28512 9097 57162 28511 4615 3725 5594 10392 51295 5604 1432 8945 8767 3654 5528 1326 4208 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 6749 2966 404672 8178 5440 2962 5441 2071 5436 2967 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes 10312 50617 1536 1535 51606 5880 245972 9296 4843 523 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis 8737 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants 2244 5245 54518 5906 5594 5604 5605 408 4296 815 816 2243 817 1445 818 283455 2266 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes 25946 57060 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 5567 5568 2782 2785 59345 5573 2783 5576 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants 5594 11221 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT 83999 3021 3065 23002 54764 1460 160 2782 1457 284654 161 3018 50999 85236 5525 23401 5579 51339 2785 3014 8549 5526 59345 9559 5527 59352 5528 2783 84133 5529 6658 8295 81847 5880 8607 387 83439 7476 7478 27327 8945 5717 5718 7480 1487 1499 5145 5687 144165 5688 8322 5689 7474 5701 8323 8324 5158 5714 5532 2780 22943 81029 57216 207 8313 9978 8370 208 6422 8968 8347 4221 8348 815 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol 117283 55190 3705 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling 90865 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC 1630 836 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events 5732 7253 2771 122876 2492 6343 10266 59350 5032 2782 5140 2785 59345 5573 10846 2783 5576 5136 50940 2781 9038 3362 5567 5568 9340 2695 10268 10267 2843 408 27115 10888 2852 2696 2870 1816 5739 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis 2531 10715 204219 388931 94101 253782 166929 29956 8877 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 11277 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades 2244 7099 51284 23643 4615 2243 695 81622 6271 6280 2266 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 1460 1457 1020 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription 4089 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction 5295 5781 1398 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling 83439 1499 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis 8789 2026 2542 2597 5105 5091 2821 2023 2538 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins 23193 6480 7341 256435 6482 6484 6487 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle 8502 7126 9352 22852 57216 253980 5783 23592 3895 10970 5295 23129 2802 10818 23048 157285 224 10726 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol 3631 3633 8867 3628 9108 55586 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 51422 6749 545 6883 7486 6882 5982 6884 5983 9156 6877 6879 53632 1460 5984 5985 1432 5883 1457 83695 8900 580 112858 5300 1020 5932 6119 6118 6873 4193 204851 54457 8445 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 9420 1585 1584 1581 405 51302 9915 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 7027 7029 91750 4605 8900 898 3065 5111 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins 387 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription 348262 10009 687 3021 3170 3065 5594 3018 85236 3014 7750 54737 117581 11171 8370 2146 8968 5931 6929 6615 8347 8348 23028 1487 5315 93986 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery 6396 57122 4927 23165 79902 55746 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization 2060 23193 3224 3609 746 1603 3021 3065 1460 1457 3018 54971 85236 3014 54737 9159 1793 6615 27327 9076 1009 23028 5717 5817 5718 1487 1499 998 5315 93986 5687 5819 348262 5688 10009 5689 687 5701 5714 64398 283 3170 3716 5594 81607 5818 329 1012 7750 7297 253559 137075 64403 9075 28513 80149 221935 1010 117581 1000 1006 1013 1004 1002 1001 11171 8370 2146 8968 5931 6929 8347 8348 4193 6185 6184 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer 4089 7046 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria 435 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription 388585 10046 2208 3002 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function 79728 7486 580 9156 5932 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation 5906 2244 5594 5604 5605 408 28956 2243 1445 54518 283455 2266 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis 197258 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 9965 152831 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases 4316 4318 4319 5340 1215 1511 80781 3818 4326 50859 4312 5644 5645 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions 4128 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 64682 11065 10393 51343 246184 51529 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing 56605 23265 3630 4644 5873 1363 57393 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 5002 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 7781 7780 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 27327 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 9153 23568 55315 222962 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin 3667 5781 8660 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 867 5295 1956 2549 11140 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity 387 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine 1468 1036 339896 23474 4357 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response 3313 545 7266 51182 27000 57805 9531 22824 116835 79902 5594 6119 6118 6396 9532 57122 4927 23165 55746 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 4089 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 30849 9110 4534 9108 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK 2520 5594 1956 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism 5214 5210 8789 5567 2542 5568 5091 2597 2645 79902 2821 2026 6396 5207 5208 57122 5209 4927 5105 5528 23165 2023 55746 2538 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy 26276 64601 65082 55823 7284 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates 4056 CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization 6749 84844 6883 7341 23067 3021 3065 64769 79595 3018 85236 84181 3014 3481 54934 79843 121536 55274 54815 2538 22992 23522 8295 23326 23569 117143 10856 51230 6944 8607 8464 10445 84193 55693 84159 10902 79723 55818 339287 54496 51780 54859 8242 55193 25855 353238 221656 23028 23030 5105 51111 80854 10765 8518 1499 10523 1728 10362 22827 51317 6638 8313 53335 6627 51639 6871 8370 55689 4654 6636 84289 4656 6635 114825 6637 2146 23613 125997 8968 23394 6941 5931 9646 6929 10320 8347 170394 8348 3054 79685 8819 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 344 345 335 348 1071 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 154743 9681 23334 523 10312 23677 652968 51606 6396 245972 9296 28956 79726 10641 64223 729438 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 5440 5441 4781 6741 6618 6617 55290 51728 661 11128 2976 10621 2971 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling 5906 5567 5568 6494 23108 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system 8662 8663 51386 3646 5336 2208 4128 50615 79923 90865 1958 5657 1445 5717 5718 5687 5688 3554 5689 5701 7124 5714 3596 10538 6348 8741 7132 1432 330 207 329 1326 4208 9978 3684 3663 8672 6396 815 816 57122 817 4927 818 23165 55746 3558 29760 79902 23586 2634 7318 4939 2633 3840 5525 5528 51447 5295 3667 103 7184 6230 6232 1437 6231 5781 6234 3977 6235 3441 2197 3439 3716 140032 6227 6229 8767 7297 7335 4582 3449 29110 3443 208 3605 112744 10392 3437 6205 6207 3654 6209 23118 3105 10000 5778 146433 5795 8877 834 28512 9097 57162 28511 4615 3725 3082 1398 867 1438 10019 5618 8660 998 7186 7322 829 8894 5594 5604 1968 9180 81603 9244 10148 54472 55223 4843 26095 3181 3595 3594 3430 3593 3664 3592 3669 1072 27250 3560 6627 6648 3575 5771 3588 5300 8809 3597 5896 5897 10379 7850 10475 2176 2187 64109 163702 6737 4869 6364 29949 79097 3576 6367 11074 3609 53832 7341 7006 6041 282618 3600 3608 64806 388646 5371 79792 3115 3113 3313 2322 1977 59067 8945 10673 1511 5783 9020 836 8744 3604 6868 60401 23495 4049 9966 4312 759 4318 2316 8968 27 4502 6888 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation 373156 4257 2952 221357 4259 26873 79094 2678 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation 5295 5294 23308 23533 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors 1133 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development 28964 8912 2107 65110 9355 4440 6585 3199 1287 2935 23129 6709 1286 1293 9826 5747 5361 2549 387 1796 1793 51466 30011 5717 7225 5718 998 8660 5687 5688 5689 2043 5701 5714 5532 26986 5594 5604 5605 5576 5362 5365 1072 1809 8482 56896 1400 1808 5567 5568 9978 4627 6124 6130 6128 5621 8911 6129 4651 57211 6141 4155 6146 2044 5376 22885 11280 2050 1460 2049 2047 3897 56963 10486 160 1457 220164 161 287 6156 6710 6334 6159 285704 57453 57731 57698 5649 8633 1630 6168 2668 6169 6160 5962 1956 3908 5295 6170 10818 8861 10048 6230 6232 6231 5781 6234 6235 6586 2197 140032 6227 10093 286 6229 27255 10097 10096 5664 11224 9037 4318 51107 1020 55851 3685 9495 27 6205 6207 4628 23380 57522 6209 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes 51706 760 51700 759 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system 611 145226 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling 51447 3105 3449 5781 6041 3443 3441 3663 3439 3716 10379 1958 2634 3437 4939 103 7297 3430 3664 3669 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication 8968 8347 3018 8348 85236 3014 4998 8370 3021 4999 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids 23054 25979 6319 60481 10025 96764 133522 8720 3155 79071 94101 253782 9440 5445 63924 427 5446 3992 2531 892 2167 6555 9439 8877 6309 3290 5476 3295 23533 51171 2194 57834 2181 51179 55300 335 336 32 8867 10449 9967 5264 81849 4056 1581 23600 22874 64834 22876 231 116255 80765 84320 5567 5568 3631 53947 126282 29956 2678 55331 79642 4074 51099 1585 9524 1584 5287 4199 5825 10998 51302 51422 57761 5294 83930 7421 9415 137964 8895 9489 1800 23760 1120 4520 51552 1460 5730 84693 1374 347527 80339 3074 162466 10809 2583 9420 9362 204219 47 1457 84649 55500 54675 56994 114971 7368 55224 4758 51365 1384 11343 11145 81490 8904 56261 2101 57153 3030 161247 79143 171586 23175 150763 254531 80306 50487 5501 4534 9200 5641 6609 65985 5295 10715 51102 28234 8228 1558 9331 1565 9453 376497 64781 23597 145482 26063 81544 9107 10728 26061 5660 5783 2274 7296 873 641371 134526 112950 9110 388931 10825 10948 5538 9108 6487 340075 30849 346606 3930 9862 9256 405 166929 284161 51003 5444 2172 2171 2170 22880 79837 123 130367 9915 10478 1024 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions 28231 11309 57153 6567 284111 116085 9123 345274 1468 353189 133418 28234 53919 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs 2322 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD 5688 5689 5701 5714 84447 5717 5718 5687 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis 5984 5985 5982 5983 5981 23649 5111 57804 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport 6687 5245 7419 9512 8165 11331 10367 80024 7416 90550 55486 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway 2101 367 3172 7421 29959 5914 2103 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 23054 30827 51230 6871 10445 23067 55689 26993 91272 4221 3054 54934 11168 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis 10675 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway 5423 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation 11004 6232 80776 79902 25909 5525 5526 5527 1063 5528 57551 5529 83540 1058 79019 91754 10783 2491 5501 8655 1781 140735 348235 1778 25936 6396 220134 57122 81930 10726 55746 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly 344 345 335 348 338 336 4547 337 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs 580 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis 7027 345643 4602 647309 159989 27327 51053 10309 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism 80765 2172 9420 28234 5825 6555 1581 23600 10998 51302 3295 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions 2060 23193 3224 3609 746 1603 3021 3065 1460 1457 3018 54971 85236 3014 54737 9159 1793 6615 27327 1009 23028 5717 5817 5718 1487 1499 998 5315 93986 5687 5819 348262 5688 10009 5689 687 5701 5714 283 3170 3716 5594 81607 5818 329 1012 7750 7297 253559 64403 28513 80149 1010 117581 1000 1006 1013 1004 1002 1001 11171 8370 2146 8968 5931 6929 8347 8348 4193 6185 6184 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 79717 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 10613 11160 5688 51422 5689 5701 5714 5717 5718 53632 5687 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 5688 5689 5701 9978 5714 3065 54764 83439 5525 23401 8945 5526 5527 5528 5717 5529 5718 1487 1499 5687 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) 546 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT 3815 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events 2782 2771 5579 2785 59345 5583 2783 150 2781 26575 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 6309 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors 56413 10800 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol 5336 5332 5333 9651 3633 8867 89869 3705 3707 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity 867 2060 5771 10254 3082 30011 5795 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation 127 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions 1630 57453 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking 57120 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins 5567 5568 2782 8766 2785 59345 5573 4645 2783 5576 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins 417 5645 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination 54386 8347 3018 8348 85236 3014 8370 7014 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway 23586 29110 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants 399473 161742 200734 4763 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 80231 3663 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) 5295 3667 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin 5295 5336 5294 2549 8660 23533 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII 867 5295 1956 2549 11140 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network 339122 6293 57511 122830 84342 22796 84316 22836 9382 4074 9367 9648 23647 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling 9958 11171 9110 5501 7046 23645 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 178 5236 5834 5836 5837 2548 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 27327 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose 29926 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity 1021 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins 2028 1636 1361 1215 1511 290 1360 1359 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development 5594 23314 367 221044 4094 10432 4089 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells 3651 390874 256297 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses 51422 28964 2752 220074 2771 1312 1141 53632 160 2782 5579 2785 4646 7915 59345 2783 8541 8497 27165 22999 10815 8499 4128 10645 3760 2900 2743 55327 200909 2901 200959 3772 2562 2557 116443 57554 1144 5924 116444 3762 3766 9568 2570 2569 55584 4900 8001 5594 10368 5573 5576 5567 5568 9256 781 774 9495 6572 2744 814 815 4193 816 817 818 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 1460 1457 5501 SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste 133060 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein 6396 57122 4927 2645 23165 79902 55746 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 23054 2101 6648 64784 96764 133522 56652 3418 11232 23373 64216 7978 814 84808 3054 2747 4208 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 6873 2962 54457 5436 2967 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 5594 1808 3897 160 161 5962 57698 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport 10540 64689 829 1639 9382 6709 286 287 6710 57731 81876 51272 54732 57511 3630 84342 22796 51014 11014 8655 1781 140735 1778 55860 2801 10121 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade 2244 196527 2243 2160 2159 2147 2158 2266 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization 100505753 8502 51350 85294 5493 3849 643394 25818 3850 353134 3851 43847 1832 3856 353133 3857 353135 353137 353139 199834 3866 353141 3868 353140 353143 353142 643414 142910 5317 643418 3713 353323 54474 81851 3875 64065 3891 353332 121391 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds 2327 4128 10728 405 66002 29785 127 2052 9420 5447 57834 1585 1584 8824 1558 1581 1565 64757 51302 9915 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants 2244 54518 5906 5594 5604 5605 408 815 816 2243 817 1445 818 283455 2266 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma 5294 2782 10000 207 2785 59345 387 208 2783 23533 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation 6749 2966 404672 8178 5440 2962 5441 2071 5436 2967 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators 1401 712 10584 5648 713 714 715 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER 4253 10960 374 9554 10113 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation 4508 4509 7284 4519 65003 51081 6150 28957 57129 54516 51021 4539 84545 51649 122704 9553 64981 4540 10240 4541 3396 118487 51373 740 51650 51253 4538 54148 55037 9801 219927 51116 29074 10102 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome 814 3065 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere 546 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) 5781 7322 7297 3716 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 3417 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids 23054 6319 96764 83930 8720 7421 79071 32 4520 9420 6555 1581 23600 10948 231 80765 3930 6309 3290 9256 5641 3295 51171 2172 2194 1585 28234 1584 5825 9453 10998 51302 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins 64682 5688 11065 5689 10393 51343 5701 5714 891 8945 8900 5717 5718 246184 51529 5687 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 2782 2785 59345 2783 998 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism 2752 2744 65263 29920 2747 27165 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines 4522 10840 6573 2350 113235 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism 100 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 176 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 51000 1836 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 1558 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins 11004 81624 6232 80776 79902 286205 23002 25909 29984 5525 5526 5527 1063 5528 57551 5529 83540 1058 79019 2491 387 5501 8655 1781 51466 140735 348235 1778 25936 6396 220134 57122 23380 81930 10726 55746 998 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes 55835 7846 8636 10540 5108 84131 4957 728642 9662 8655 7840 1781 22995 22897 7283 1778 54930 1453 11190 27229 23354 114791 80254 85378 121441 55755 10806 10121 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 57461 10920 1642 5982 5983 5440 5441 5111 5984 56949 5985 2966 2967 9978 2071 6119 404672 6118 8178 5981 5436 64708 50813 7874 57804 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 2239 335 336 54884 337 2719 344 345 348 338 221914 9672 1208 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations 2218 10559 79147 84197 113829 729920 120071 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle 28964 22865 81624 116984 55114 50508 23592 1536 1535 7879 57580 10811 55914 55843 4810 3930 182 10152 2010 55971 613 143872 26050 5295 3071 27 4162 10163 23380 4983 29127 998 11135 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL 1460 1457 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis 6648 3725 708 1020 2801 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 7186 4049 330 329 10673 9020 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 546 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production 7132 7124 8439 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway 23118 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization 2060 23193 3224 3609 746 1603 3021 3065 1460 1457 3691 3018 54971 85236 3014 5339 54737 9159 1793 6615 27327 9076 1009 23028 5717 5817 5718 1487 1499 998 5315 93986 5687 5819 348262 5688 10009 5689 687 87 5701 5714 64398 283 3170 3716 5594 3611 55742 81607 5818 329 29780 1012 7750 54751 7297 253559 137075 7016 64403 9075 28513 80149 221935 1308 1010 117581 1000 1006 1013 1004 1002 1001 11171 8370 2316 2146 8968 5931 6929 8347 8348 4193 6185 6184 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters 115019 1836 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 57554 814 815 816 817 818 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA 7915 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling 6367 3554 7124 2208 1437 3588 6348 3716 7850 7132 7297 3593 6364 3592 3576 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 388585 10046 9978 182 51107 55851 3065 10014 3714 6868 892 142678 57534 5664 22938 1024 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism 9615 7498 9583 151531 377841 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways 4651 4644 2771 1800 644150 1535 2782 2785 10768 79792 59345 2783 10910 2781 10800 917 5027 834 5747 29108 5336 3725 10152 5025 719 695 1398 1793 3071 10163 998 7474 8324 1511 6868 5594 1432 10093 10097 10096 5573 10811 5576 10810 5567 5568 7454 4627 2678 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) 3313 6648 207 9361 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK 5984 5985 6119 6118 10459 5982 5983 51455 5981 5111 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis 3930 6309 9453 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import 51024 5825 5193 10478 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions 286 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division 9126 10735 23063 23383 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 7296 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) 7166 1020 387 1398 3400 10221 5906 1958 5295 5594 5604 10818 1432 5605 160 3667 161 5528 4208 8660 6014 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling 10613 51422 23476 5688 5689 7004 201595 5701 7005 5714 746 5781 1603 3021 8463 80380 3716 53632 1460 1457 3018 142678 85236 3014 3115 3113 917 9978 3725 2034 8370 2146 11160 84061 83439 8968 5931 8347 27327 8348 8945 1445 5717 5718 6185 1499 6184 5687 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body 51293 6948 55788 6947 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation 11168 7518 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade 2239 196527 2719 3818 6609 5197 2161 5657 221914 2160 5270 9672 2159 2147 2158 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules 10313 5789 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes 3609 6230 7341 6232 6231 6234 6041 6235 79902 2197 3716 8662 140032 8663 8894 51386 23586 2634 1968 3646 6227 7318 4939 2633 3840 3608 6229 5525 8877 834 5771 5300 2316 8672 3437 1977 6396 2176 2187 103 6205 57122 6207 4927 23165 6209 4869 55746 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5688 5689 5701 9978 5714 7322 2034 64344 84962 8994 5717 5718 5687 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 6749 5440 5441 2071 6830 27125 9646 404672 4300 2966 8178 2962 5436 2967 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation 5567 5568 5573 5576 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events 28964 57554 51422 5924 5567 5568 10645 4900 53632 5594 814 815 816 817 818 5573 5576 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint 545 7486 5982 5983 8370 9156 5932 5984 5985 891 6119 6118 8347 5883 3018 8348 85236 83695 8900 3014 8924 580 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway 58478 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis 3105 160 51606 161 130340 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 7341 8370 2138 8347 3018 8348 85236 23030 3014 8924 580 2140 322 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) 611 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm 7849 3975 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy 100188893 7335 7419 29110 7322 7416 9927 1460 1457 7332 9474 54543 55669 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling 5332 10000 2771 4295 5583 10266 129521 2151 23566 56413 2865 9630 1133 8525 6866 5032 94233 2782 885 5028 5029 5579 2785 84432 139189 59345 1902 2783 6375 57121 2922 9826 4828 2781 10800 26575 9038 2520 3362 611 5997 2846 9828 22899 9170 222545 10887 9340 623 50835 624 53829 747 2832 1607 2831 387 2695 26166 695 10268 1903 10267 84152 23533 338398 2843 85397 408 445328 27115 10888 2852 2696 2870 7225 63940 998 5739 2587 5732 5733 5924 8862 26086 2918 9560 9283 5532 259294 2780 6343 23596 9290 9294 59350 1325 353164 5368 5594 207 5573 5576 553 5567 5568 4852 814 815 816 817 818 1816 6372 1815 6364 6357 3576 5294 7253 122876 2492 5140 10768 10846 5528 5136 11343 150 50940 10645 719 1956 5295 83756 50831 50833 50832 50834 50837 50836 50839 9568 50838 50840 5660 2847 57580 2147 5726 54429 80835 1020 208 259289 259287 259286 259285 2864 259293 259292 259290 259296 259295 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis 3906 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation 7363 11046 55347 54659 10720 54579 10941 133688 574537 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 5688 5689 5701 8535 5714 10000 80012 3065 648 10014 1460 5594 23608 1457 207 5371 54815 80243 81847 3725 2444 208 2146 1958 5931 6615 27327 28956 23028 5717 5718 64223 7874 5687 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation 87 335 51706 7044 7123 5340 29789 350 94121 6403 3959 5660 23052 9948 813 7873 374354 3920 3479 2243 3481 7273 1072 2266 7042 2244 967 3082 2316 1675 928 5175 5005 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production 170506 4615 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus 11168 7518 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK 5295 3667 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy 3920 123 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated 5525 5526 5527 5528 5529 1499 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels 3782 3781 27345 3779 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K 5295 3667 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling 6367 4582 7124 4318 4128 2208 3596 3082 10538 3684 79923 3597 3716 3605 5295 112744 207 4843 7297 7184 4312 3593 3592 3576 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions 87 3611 55742 29780 54751 7016 2316 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases 476 479 5350 481 483 486 495 496 490 491 10396 6588 57130 23200 815 816 148229 817 818 374868 51248 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors 10000 207 208 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA 147945 11277 29110 6737 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor 9630 2782 2785 59345 2783 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 867 207 1796 5753 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR 3791 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification 51335 55006 10128 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis 4967 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones 51780 8968 8242 221656 23030 23028 55693 8370 84159 10765 55818 22992 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade 23118 7099 7186 64145 23643 51284 5594 5604 1432 8767 5528 1326 4208 30849 7335 28512 9097 57162 28511 4615 3725 80231 3663 10392 51295 8945 3654 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors 2782 9340 2785 6343 59345 2696 2695 2783 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 64682 11065 10393 246184 51529 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis 5688 7099 5689 7186 355 5701 8797 5714 10000 8737 3002 23643 3009 708 3007 1832 6304 3006 836 4836 5594 6709 5317 207 329 22900 79792 5339 7027 5747 7029 1630 208 8655 140735 4137 63967 5717 5718 1499 1687 5687 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 6648 3630 2908 5105 181 2645 4089 4852 3065 2538 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development 182 3172 3975 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria 7027 7029 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas 3908 3913 2252 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 388585 10046 9978 182 51107 55851 3065 10014 3714 6868 892 142678 57534 5664 22938 1024 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle 22999 10815 6572 8499 9256 8541 8497 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid 127 2171 5914 10170 195814 57665 1381 8608 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 25979 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair 545 7486 5982 5983 9156 5932 5984 5985 79728 6119 6118 5883 83695 580 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling 53834 161742 200734 27006 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 64398 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling 5295 1956 2549 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling 1956 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones 6883 79595 64769 3018 85236 54934 23522 8295 23326 117143 10856 51230 6944 6871 8607 8464 10445 8370 55689 10902 84289 339287 8968 5931 54859 8347 8348 3054 8518 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion 5688 5689 5701 5714 84447 5717 5718 55733 5687 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands 355 8797 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis 7027 7029 10000 3002 708 208 8655 836 4836 140735 5594 207 22900 79792 1687 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 23118 7335 10392 8767 3654 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells 2752 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration 10000 207 208 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 65985 3155 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR 1956 374 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 6873 2962 54457 5436 2967 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 23054 1374 96764 8204 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants 2244 5245 54518 5906 5594 5604 5605 408 4296 815 816 2243 817 1445 818 283455 2266 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism 51293 6948 55788 326625 4548 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal 4255 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) 5336 8660 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP 657 658 659 9350 268 4089 4090 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 11004 6232 80776 79902 25909 5525 5526 5527 1063 5528 57551 5529 83540 1058 79019 2491 5501 8655 1781 140735 348235 1778 25936 6396 220134 57122 81930 10726 55746 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism 594 549 152926 10295 26275 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy 1460 1457 9474 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants 2244 5245 54518 5906 5594 5604 5605 408 4296 815 816 2243 817 1445 818 283455 2266 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair 54386 10038 6996 5982 5983 8505 5423 8370 5111 5984 5985 6119 6118 8347 4913 3018 8348 85236 3014 5981 7014 57804 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones 2673 30827 27230 10897 2081 116138 22872 84447 5526 1639 10113 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 10058 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules 476 1179 479 9311 5350 219931 51706 481 51700 8720 483 486 9123 7809 523 495 6543 496 6546 490 1831 491 10110 10396 10312 50617 55244 6340 115286 94015 146802 6588 2782 57130 9296 23678 2785 148229 59345 53373 6339 2783 55515 6338 40 23 10351 20 6548 55911 2495 51248 5717 7225 5718 54795 59341 55503 5687 5688 79054 10613 5689 5701 8165 5714 335 336 337 8884 7416 345274 8894 6517 1968 344 6530 133418 341 345 51606 338 348 6523 4547 363 5573 30061 5576 6575 5567 9843 23428 5568 5002 9056 10991 23657 10559 80024 6508 9990 94033 1468 11160 152519 353189 563 123606 57380 815 5825 816 817 818 10058 11046 116085 1071 9152 7781 7780 283375 160 161 48 4645 90550 55486 53919 6687 28231 11309 5245 9512 57153 6567 11331 284111 115019 10367 154091 6527 80772 6561 6574 1317 6248 83733 28234 1836 376497 55315 28965 222962 9153 23568 7419 6550 389015 6549 51000 8766 759 760 196527 2040 113235 84061 57127 246213 23200 245972 1186 1185 1184 374868 1183 1182 1181 537 133308 1180 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing 79622 11066 10594 51639 5440 2962 5441 6636 5436 24148 6635 6637 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation 7027 1871 7029 10046 4854 3725 1999 8370 3021 8968 8347 3018 8348 27327 85236 3014 22938 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription 348262 10009 117581 8370 3021 3065 2146 5594 8968 5931 6929 6615 8347 3018 8348 85236 7750 23028 3014 1487 5315 54737 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 708 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids 5446 4056 5445 5444 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase 7027 1871 7029 5520 1021 898 1870 1032 1031 1030 1029 5753 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 10402 28 124872 10690 8707 6484 6487 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) 8322 7474 8323 8324 30817 9340 6343 2695 10266 10268 10267 7476 2782 7478 2785 59345 2696 2783 7480 6608 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation 23193 201595 5887 9117 11196 746 23243 64689 5537 10960 1603 1639 79053 9382 10113 6709 287 6710 124872 57731 4758 9554 54732 80267 10206 56886 10402 84447 51014 7844 55757 11014 5476 11236 10020 374 8655 1781 140735 1778 22872 1453 55860 9331 10121 10540 829 55577 2673 5973 51005 286 256281 4249 81849 4248 10825 4121 79947 79090 6482 57171 29926 81876 6484 197258 6487 51272 57511 6480 4253 3630 84342 22796 10559 256435 51399 122553 84061 7109 11282 10195 55741 6396 11320 6185 2801 6184 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex 83439 4221 207 8945 208 6658 3065 1487 1499 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 9180 9244 3977 7297 3716 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 90268 84888 5332 8439 56928 3002 1287 1978 1286 1293 92335 81617 5336 84447 7060 90865 8870 9965 152831 6801 23533 1958 23239 84335 22873 6615 445328 30011 5105 3791 57534 1487 283455 388585 22808 22943 11221 54518 55733 858 344 348 553 9047 127 51422 5294 83999 3714 284654 50999 51339 5140 8549 9559 59352 84133 6658 150 10750 5481 8483 9113 27018 51072 10048 7166 9110 23163 3930 2864 2771 4295 5583 129521 2151 23566 56413 2865 1133 8525 6866 5032 94233 885 5028 5029 84432 139189 1902 6375 57121 2922 4828 26575 2520 5997 2846 9170 222545 10887 623 624 747 3082 85440 1607 2549 2695 374 50937 2252 27006 83439 4602 7249 23028 64837 10019 81930 29127 998 55669 11004 9927 3479 51606 7879 1072 4627 5300 4145 6422 28956 4193 6372 64223 6364 7874 6357 3576 6367 51554 7253 367 122876 2492 80820 2908 1071 5914 835 53632 1460 1457 5371 3481 79109 11343 8295 8607 1956 8655 10221 55818 1781 1778 8945 221656 23030 8502 8301 7126 390 29766 5340 9352 22852 57216 1215 1832 10505 253980 23592 3895 836 10970 3815 6868 10093 4296 25909 10097 10096 23048 1063 10170 57580 195814 10811 57665 10810 1381 80243 55843 8608 4316 29941 1730 1058 4318 79019 5930 10254 23616 7454 26049 1020 7170 2040 8370 55971 84317 2316 143872 10788 2146 55852 10144 8968 5931 9367 348235 27 8347 4221 57120 2324 220134 8348 57480 4628 23380 11329 57522 4983 537 51306 1024 221178 28964 22865 101059918 6319 58504 81624 80776 116984 55114 708 5440 5441 50508 22836 4771 10266 3021 5585 3065 5586 286205 23002 644150 23129 1536 1535 892 398 6709 3018 85236 29984 5579 4646 3014 157285 4649 57551 2631 54815 144402 9826 4810 83540 5747 9828 22899 23286 2208 5361 8476 5880 10152 2010 29843 2491 695 84144 613 6280 70 51466 140735 26050 2802 3071 25936 4162 10160 79180 10163 1445 224 5717 55831 5718 10726 128239 1499 11135 5687 8239 5688 54509 5689 5924 87 5701 7124 8535 5714 80012 6348 648 10014 7528 57610 7132 1432 330 142678 207 329 81858 8313 374654 5573 9742 4208 5576 83737 6608 80199 51098 55764 5567 5568 9978 4852 161742 200734 64926 153090 4763 399473 10156 6929 814 6396 815 816 57122 817 818 2962 4089 5436 55746 3558 79902 1030 160 161 5525 6710 23401 5526 5527 5528 5529 57731 11140 55914 3913 5245 182 2668 3400 3908 5295 238 10818 3667 4192 27327 83756 50831 50833 50832 50834 50837 50836 6232 50839 1437 50838 5781 50840 3716 51125 8767 2243 7297 2147 6484 2266 6487 2244 30849 5726 54429 80835 7058 29110 208 259289 259287 259286 259285 245972 259293 259292 3654 259290 259296 259295 5327 23118 10000 5778 51114 523 5795 54764 10312 9630 50617 2782 9296 2785 59345 898 2783 8877 10574 2781 22938 6014 10800 7027 9038 611 3362 1871 3350 7029 10046 4854 10402 30817 4615 9340 3725 50835 1999 6421 53829 2034 2832 387 2831 26166 1796 1398 10268 1903 1793 10267 55620 5753 84152 338398 867 2843 85397 7476 3792 408 2194 7478 27115 10888 7919 2852 2696 1438 2859 2870 7225 63940 7480 5739 8660 2587 5145 144165 5732 5733 8322 8862 7474 7186 26086 355 8323 8797 8324 2918 8737 5158 9560 5532 9283 259294 7322 2780 6343 81029 627 23596 9290 9294 59350 1325 2532 353164 7046 5368 5906 5594 5604 5605 341 23608 7332 3560 3630 5771 4722 5896 5897 5825 1816 1815 3178 54845 2060 57761 7006 51719 10768 10846 9986 58489 5136 51104 50940 2322 81847 2444 10645 719 5501 1975 1977 4548 221002 5596 2562 2118 57554 9568 10728 53834 5660 5783 2847 5664 4090 23645 7042 657 91 658 9958 659 51107 11171 9350 268 55851 3685 4654 4656 2172 2171 9126 10735 2288 54659 8204 7031 79837 7010 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma 1956 374 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense 834 2634 2633 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination 3908 57211 4155 5376 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins 6396 57122 4927 1104 23165 79902 4869 55746 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 3766 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance 546 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 5747 5520 3685 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway 9355 391211 81285 504190 256892 390058 26532 390059 26658 26539 26538 2782 341276 343172 390063 390064 390066 79541 282763 283694 283297 219429 126370 390151 120787 442191 390167 390326 144124 144125 283159 403253 401993 391107 81797 81399 26696 120586 8861 120065 120066 81696 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling 5567 5332 5568 5532 2771 10645 1020 84152 9630 5594 2782 814 815 816 10768 2785 817 59345 818 5573 5528 2783 5136 5576 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation 3105 1536 1535 7318 6468 9554 55176 50489 4615 695 6280 22872 8945 5717 5718 246184 51529 5687 64682 5688 11065 7099 5689 10393 5701 51343 5714 23643 7322 997 154881 7320 91694 23608 142678 79654 84961 8924 2243 51444 7319 22888 7332 64320 83737 6049 2266 25831 30849 23014 2244 7335 27252 64718 642 5930 9978 57674 25793 11275 55658 54926 4591 51619 3685 64410 55182 26259 51465 144699 9730 25898 84727 146330 92591 6396 140460 80176 54620 55236 53339 51752 6737 6271 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD 10675 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling 5688 5689 5701 5714 8945 5717 5718 9020 5687 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair 10038 545 7486 5982 5983 9156 5111 5984 5985 51750 5883 3018 85236 83695 8900 5531 3014 8924 580 8370 80198 146956 5932 79008 197342 79728 10721 6119 6118 8347 5429 8348 63967 5981 57804 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism 5236 130589 231 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 10000 207 208 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination 54386 6996 8347 4913 3018 8348 85236 3014 8370 7014 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME 9153 100 4830 55315 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport 80772 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment 7335 330 8737 329 7322 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 10818 5781 627 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System 708 5440 5441 4771 3021 644150 427 1536 1535 6709 3018 85236 3014 4125 5747 5336 5880 10152 6278 5476 5068 6037 695 503618 6280 475 80341 84659 3347 114770 51295 140881 3071 1113 3346 51297 140850 10163 417 4257 5657 51248 5717 5718 81622 1499 5687 54509 5688 5689 712 10288 5701 5714 27180 5236 6993 51071 1432 330 329 1326 4208 83737 115004 11314 5567 5568 10326 3684 80231 9450 3663 51411 1675 629 6271 8566 51552 3074 23586 7318 47 161 1992 5528 272 5295 147945 11277 178 197358 7184 5591 5781 3441 2821 3439 51284 51125 8767 2243 2161 2147 2266 2244 30849 7335 4582 394263 5199 3449 5873 29110 4585 196527 3443 727897 84061 10392 23200 245972 3654 51728 661 11128 10621 5269 23118 5328 5049 5648 523 5795 10396 55593 10312 50617 1401 10584 9296 10910 9447 917 5027 834 29108 28512 9097 57162 28511 4615 3725 387 1398 1793 2495 4179 1361 5878 1380 1369 730 713 735 714 715 998 5315 7099 7186 64145 8737 5532 23643 7322 997 829 290 5906 5594 5604 22875 51606 338 54472 7879 4843 2206 80301 64170 10695 2548 1072 2352 124583 388697 967 83716 4627 127829 5300 10493 3240 2799 5787 5547 353189 28956 284266 57826 170482 6737 4033 55313 5005 326624 3417 1687 6590 5273 5036 4651 29952 4644 154664 7006 5834 9545 5836 10394 835 8895 9342 79132 3916 7294 1460 3920 170506 26253 51719 5317 3608 10768 84418 79792 4758 3702 10855 8904 57153 6947 2444 719 8655 5641 1778 8945 55860 1512 9474 57554 55276 1832 1511 5660 3818 9020 836 10970 10093 10097 10096 10810 5645 4318 7454 8370 2040 3685 10788 8968 8347 2171 8348 5175 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism 81544 284161 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 2542 6888 378884 5507 2538 2548 2799 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 54675 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 2324 3791 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism 340075 427 4074 79642 347527 3074 5476 10825 4758 5660 6609 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5520 6129 6230 6232 6141 6231 2107 6234 65110 6146 6235 23381 2197 23293 2935 26986 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 5688 5689 388585 10046 5701 9978 182 5714 51107 55851 2324 207 5717 5718 5664 22938 5687 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine 54386 6996 8347 4913 3018 8348 85236 3014 8370 7014 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 6129 6230 6232 6141 6231 6234 6146 6235 2197 8662 26986 140032 8663 8894 51386 1968 3646 6227 6229 6156 6159 11224 6168 6169 6160 6124 1975 6130 6170 1977 6205 6207 6209 6128 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage 79792 836 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 7042 408 7046 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism 3992 60481 9415 64834 3295 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 182 51107 55851 5664 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling 7322 7297 3716 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 30849 57761 2322 5781 208 2549 9965 2252 8483 152831 27006 5295 3479 10818 3667 5140 3481 8660 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins 2159 2147 2158 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors 4208 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism 10678 11046 9348 57214 90161 176 9956 8372 26035 10675 3074 51000 11261 221914 6482 3161 9672 3038 337876 10855 6484 6487 6548 2239 10402 9435 2719 2799 1836 9331 64132 9917 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 867 27 2322 1445 10019 5795 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair 10038 8505 5423 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity 1021 27327 5781 5371 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair 5984 5985 6119 6118 5982 5983 5423 5981 5111 57804 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH 2678 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex 7027 7042 7029 9958 11171 387 5501 3685 3065 1030 7046 867 5594 892 4221 9110 4089 22938 23645 1024 8239 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis 9453 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs 3815 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs 238 53335 5573 3092 4869 6801 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA 8741 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse 4627 4628 387 9826 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 629 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells 867 2060 10254 30011 1499 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism 64777 10048 4199 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane 23265 84100 2847 8766 5311 55212 6608 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance 348 338 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import 26063 373156 7322 3155 26061 3295 5191 54469 51179 51268 4843 5264 23600 1384 3417 5193 8239 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 55835 57472 5325 9125 29883 4869 7832 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) 9900 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation 160 51606 161 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 3082 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 6888 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 207 2643 6697 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes 8968 891 8347 3018 8348 85236 3014 8370 3021 23310 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis 5688 5689 6868 5701 5714 84447 5717 5718 55733 5687 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 6868 182 3714 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis 5984 5985 6119 6118 5982 5983 5981 23649 5111 57804 SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes 6749 23054 6883 56259 6882 5982 6884 5983 10200 79733 5440 10538 5441 1870 5393 9156 6877 5111 6879 11340 22894 5984 23404 5985 54512 51013 118460 6830 27125 9646 6929 4602 4300 8178 10459 5429 51455 6873 144455 2962 54457 27301 5981 5436 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis 5236 378884 5507 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins 6396 57122 4927 11168 23165 79902 55746 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis 7027 2313 7029 5914 8370 3021 688 8968 4602 8347 3018 8348 85236 2672 3014 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 3074 176 2799 EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle 11168 7518 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle 23193 80267 10206 55741 56886 84447 7844 55757 11236 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense 834 2633 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants 238 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism 145482 10728 2678 1800 5445 5444 5730 5446 873 57834 1558 4056 376497 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors 10266 10268 10267 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity 1733 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions 2244 7087 1286 2243 3684 5175 3791 2200 3685 80781 2266 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation 1401 712 713 714 715 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO 7341 29843 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters 9843 6548 80024 6543 1317 6546 7781 6550 7780 389015 283375 6549 30061 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter 5440 5441 51728 661 11128 2976 10621 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK 2782 2785 59345 695 2783 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters 6561 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion 403314 339 10930 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle 27127 51451 10734 27030 5520 80776 10000 5440 5441 3021 3065 51750 7280 3018 85236 5579 79861 3014 23063 898 57551 3161 83540 7027 22822 1871 728642 7029 51230 91754 2010 10783 2491 5753 140735 91750 25936 2305 27229 5717 81930 114791 85378 5718 10726 5687 5688 5689 11004 5701 5714 79075 79991 64326 84515 8318 9837 51659 5594 1432 207 8900 8924 9978 4605 57060 5932 6119 6118 6396 57122 4193 4927 51053 4998 23165 4869 4999 5436 55746 23649 2801 545 25946 7486 5982 7341 5983 1021 25978 23243 64689 79643 5537 1104 51652 1870 255919 80119 79902 9156 5111 1030 1460 5984 5985 5883 1457 5525 83695 5526 580 5527 5528 5529 7014 54386 546 10856 23175 8607 1876 5501 9662 8655 7840 1781 22995 22897 7283 891 1778 54930 84962 1453 8945 11190 9133 23354 80254 121441 246184 55755 51529 10806 10121 1029 64682 55835 11065 7846 10393 8636 10540 51343 5108 6232 84131 4957 64151 51773 54069 9088 23592 23383 23310 7298 25909 1063 81876 1058 79019 3930 8370 208 55505 8968 5931 1736 348235 8347 9126 220134 10735 8348 63967 5981 1032 9985 1031 57804 23353 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 6868 142678 182 57534 3714 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle 29941 9828 81624 3930 708 2040 387 5585 5586 613 23002 5295 4162 5825 57580 4983 29127 128239 55914 9826 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP 335 336 8720 5340 1511 3895 813 10970 3479 338 348 2243 3481 4312 2147 3913 2266 1000 2200 2719 80341 64856 11320 54757 10232 4221 11098 3491 3489 7184 54587 3488 3487 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina 891 23175 5579 2010 255919 23592 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics 1558 1565 405 9915 29785 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD 594 152926 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus 51107 55851 5664 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 3030 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 23054 6319 96764 2194 6309 8720 79071 32 9453 4520 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome 5594 22900 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors 5567 5568 5207 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 9990 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis 5594 57674 6421 1511 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein 7341 6732 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) 10038 10721 5932 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer 7046 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair 545 7486 5982 5983 9156 5932 5984 5985 79728 6119 6118 5883 4913 83695 580 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion 2060 23193 3224 3609 746 1603 3021 3065 1460 1457 3018 54971 85236 3014 54737 9159 6615 27327 1009 23028 5717 5718 1487 1499 5315 93986 5687 348262 5688 10009 5689 687 5701 5714 3170 5594 7750 64403 28513 80149 117581 1006 11171 8370 2146 8968 5931 6929 8347 8348 4193 6185 6184 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation 5579 10768 3791 8877 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 1460 5594 3897 5604 5605 1457 1956 3685 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 11046 51000 10559 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance 341 160 335 348 338 161 55911 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG 747 11343 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 6278 6280 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism 4125 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions 1558 1565 29785 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis 6480 10402 10559 256435 5476 10020 55577 2673 5973 51005 256281 81849 10825 79947 6482 4758 57171 29926 6484 197258 6487 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling 10818 5781 9965 152831 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB 4615 8767 3654 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases 23118 10000 5440 5441 523 3065 5795 1287 10312 50617 1536 1535 1286 9296 5579 1293 8877 6014 5747 10152 3082 7060 85440 2549 387 374 1398 9965 1793 2252 152831 27006 5753 1958 867 3071 30011 10163 1445 10019 3791 998 8660 1499 627 5906 3479 5594 5604 57610 5605 1432 51606 348 207 4208 83737 5567 5568 3630 5771 9047 4145 161742 200734 2962 5436 64223 3178 54845 2060 57761 7006 160 161 5140 10768 3481 5528 11140 79109 55914 3913 2322 1956 10750 3400 10221 8483 3908 5295 238 10818 3667 4192 2562 51072 10048 7166 5781 5340 1215 53834 3815 6868 5664 10810 23163 30849 4318 10254 7058 51107 1020 55851 208 3685 2324 245972 537 5327 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET 23163 5747 2060 10048 5771 10254 5781 3082 85440 2549 1398 5795 5906 3908 867 5295 57610 30011 3913 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 5621 27230 9381 2010 7485 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 5688 5689 5701 5714 64326 5717 5718 5687 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion 93343 7251 25978 51271 79643 51652 10015 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D 5688 5689 5701 5714 5717 5718 5687 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 79728 7486 580 9156 5932 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide 760 761 765 766 759 23632 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation 6749 8178 5440 2962 5441 5436 ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes 5984 5985 10459 5982 5429 5983 51455 9156 5981 5111 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence 50488 9448 8535 1021 80012 1870 3021 648 4217 1030 5594 1432 3018 85236 3014 7027 1871 7029 3725 8370 2146 8968 5931 8347 27327 8348 4193 1032 1031 1029 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription 23129 23286 388585 10046 4854 22938 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria 7027 7029 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 6523 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 23118 7099 23643 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway 57761 10000 1536 1535 1432 207 5579 10768 79109 10810 8877 5747 5567 5568 10152 9047 387 208 3685 1398 1793 5295 3071 10163 3791 64223 1499 998 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 176 6487 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation 4316 1308 4318 1306 4319 80781 4327 6868 9313 4321 164656 1303 4312 5645 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle 51422 1374 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin 7296 928 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade 30849 57761 2322 5781 208 2549 9965 2252 152831 27006 5295 10818 3667 5140 8660 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits 6129 6230 6232 6141 6231 6234 6146 6235 2197 8662 140032 8663 51386 3646 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade 23118 7335 7186 28512 9097 57162 28511 4615 3725 5594 10392 51295 5604 1432 8945 8767 3654 5528 1326 4208 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated 5525 5526 5527 5528 5529 1499 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis 27068 5464 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation 5440 5441 4781 6741 6618 6617 55290 51728 661 11128 2976 10621 2971 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants 26127 5295 7750 613 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing 8106 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 10025 5440 5441 3065 9440 2966 892 3018 85236 11168 5479 57551 9439 54815 2967 5336 695 140735 9076 30011 5717 5718 1499 10523 5687 5688 3554 5689 712 5701 57794 5714 335 22827 6993 26986 56949 6638 10594 207 10236 23524 83737 115004 10465 11314 7301 9978 5119 10313 51639 29959 8896 51645 6124 24148 4061 8672 6130 9646 8178 6396 85313 815 6873 816 9532 57122 817 10084 4927 818 11051 2962 54457 23165 4089 10294 5436 55746 51585 7518 6128 10280 10015 23476 6749 57461 93343 84844 6883 6129 56259 6882 6884 6141 7251 22924 25978 9360 51271 79643 6146 29760 1104 1993 51652 79902 6877 6879 9382 4836 51729 23586 7318 4939 160 2633 161 3840 80273 6156 6159 6168 6169 6160 5295 6170 6230 6232 6231 5781 6234 64398 6235 3441 2197 7284 3439 3716 140032 51284 26276 6227 51125 65082 112950 6229 8767 4249 7297 221914 6482 9672 2147 6441 6484 6487 30849 7335 64601 6480 2239 3449 29110 256435 196527 3443 208 2719 6636 6635 6637 3605 84061 112744 10392 11282 3437 84313 55741 11320 6205 6207 55823 51304 3654 6209 8487 6185 23479 6184 476 23118 11218 23193 201595 3105 10000 481 746 483 51114 486 6732 5648 1603 1312 22938 10800 834 29108 130340 2194 9785 5878 199746 23028 7099 8737 23643 10362 51317 51606 3181 6627 55236 4869 64223 3178 7341 2908 1460 1457 5371 79109 80306 5501 1956 8655 8106 1781 1778 1977 25855 8945 10728 11224 4318 9862 8370 2071 51003 2146 8968 5931 404672 8347 8348 2288 79685 8819 1024 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 5460 55211 6997 79923 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication 64682 5688 11065 5689 10393 51343 5701 5982 5983 5714 3021 84515 56652 8318 9837 5111 51659 5984 11232 5985 3018 85236 8900 3014 898 9978 8370 92667 8968 6119 6118 8347 8348 51053 4998 5717 4999 5981 5718 23649 246184 51529 57804 5687 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 867 9180 9244 5781 3977 7297 3716 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway 29108 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis 3626 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 3074 PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization 5621 100188893 26063 373156 7322 3155 26061 7416 10651 27230 29090 80273 4843 5264 516 23600 10440 4714 1384 51287 3313 51025 10245 400916 9512 9381 51024 150274 2010 3295 5191 54469 51179 617 5825 51268 7485 3417 10478 5193 54543 8239 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway 30011 5649 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 7046 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome 834 29108 9447 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor 2900 2901 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis 8525 747 1607 139189 5583 7225 11343 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis 10402 124872 10690 8707 6484 6487 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins 5906 2244 5747 2243 54518 2266 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism 3992 60481 9415 64834 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein 23193 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes 6882 6884 5440 5441 6877 65123 57508 23248 54973 25896 6618 8178 6617 55726 79035 2962 5436 51585 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism 653509 5029 729238 1512 1438 1755 6441 150 10970 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses 9456 22839 22865 8499 9369 22941 57502 54413 127833 80059 10313 26050 143425 84631 94030 81858 5789 84189 55327 8541 347731 8497 347730 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function 5688 5689 2060 5701 54971 5714 4193 5717 5718 1499 5687 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway 7099 10025 23643 3441 9440 3439 3716 1460 51284 23586 4939 892 1457 112950 7297 221914 9439 9672 9978 2239 3449 9862 80306 3443 1956 5501 2719 51003 5878 1024 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type 10675 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 5567 26251 5568 3630 2771 9495 3790 9630 5906 2782 2181 2864 10768 2785 3745 59345 5573 2783 5576 150 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity 5594 22900 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery 6749 8178 5440 2962 5441 5436 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation 10352 25973 3376 57505 8565 6897 7407 27068 2617 2193 9255 5464 51067 124454 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling 11074 3105 7341 5781 3716 5594 2634 4939 81603 2633 55223 388646 5371 3115 3113 3664 3663 10379 10475 815 816 817 4502 818 6737 79097 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones 8720 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification 9117 11196 23243 64689 5537 10960 1639 9382 10113 6709 287 6710 57731 9554 54732 51014 11014 374 8655 1781 140735 1778 22872 1453 55860 9331 10121 10540 829 286 4249 4248 4121 79090 81876 6484 51272 57511 6480 4253 3630 84342 22796 51399 122553 7109 11282 6396 11320 2801 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events 5567 5568 814 815 816 10645 817 818 5573 5136 5576 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants 238 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy 93343 7251 25978 51271 79643 51652 123 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases 340075 79642 347527 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism 57153 501 55349 29958 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 5295 10818 5781 2549 2252 27006 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters 6575 6574 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation 23118 7335 10392 1432 8767 3654 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 388585 23286 10046 4854 182 51107 55851 1956 3714 23129 142678 57534 5664 22938 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 57761 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 8894 1968 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events 5567 5568 5532 1020 5573 5528 5576 84152 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 5781 3082 2549 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 5027 8912 207 3685 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling 51422 10000 208 53632 1975 84335 51719 1978 7249 1977 27327 28956 207 64223 92335 81617 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 814 816 10645 818 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 79814 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 1956 374 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization 7784 928 378807 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 57834 4056 2678 1800 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 5688 5689 5701 9978 5714 5717 5718 5687 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 55193 55274 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland 374 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease 22894 23404 54512 51013 118460 5393 11340 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 64682 5688 11065 5689 10393 5701 5714 891 8900 5717 5718 246184 51529 5687 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events 5906 5594 5604 10818 5605 1398 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism 1468 1036 339896 875 58478 191 4548 23474 4357 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle 9927 55669 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense 2634 2633 7322 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition 5688 5689 5701 5714 10000 84515 3065 8318 5111 7298 207 8900 898 7027 7029 1876 208 5753 891 6119 6118 91750 51053 4998 5717 4999 5718 23649 5687 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) 23054 6319 96764 2194 6309 79071 32 9453 4520 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated 5525 5526 5527 5528 5529 1499 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 7978 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance 341 338 55911 MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase 64689 255919 3021 79902 23592 23310 5594 3018 85236 5579 3014 81876 23175 91754 2010 10783 8370 8968 891 8347 6396 8348 57122 4927 9133 23165 55746 2801 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 7027 55835 5325 25946 7029 79733 57060 7832 5111 57472 891 9125 8900 144455 29883 898 4869 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex 4998 84515 4999 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 23054 1337 1345 571 96764 1339 81502 1350 55620 5753 613227 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function 3224 3609 6615 1006 27327 1009 64403 1499 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity 6749 51422 545 25946 6883 7486 6882 5982 6884 5983 10000 133746 5457 9156 6877 3065 6879 64769 53632 1460 5984 5985 91875 5883 1457 54971 83695 5371 580 5527 112858 3622 79109 54815 133383 51230 1432 207 8900 5300 1020 208 117584 84289 5932 5931 6119 6118 6873 4193 204851 54457 79837 64223 7874 8445 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 5567 26251 5568 9495 3790 5906 2782 2785 3745 59345 5573 2783 5576 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 90268 11065 3105 7322 997 5111 7320 3018 85236 7319 7332 54926 9646 8347 29089 8348 55236 5591 9810 92305 220441 9781 7874 5193 8239 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 1437 5579 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis 7186 8737 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells 3908 3913 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing 55006 25821 79693 3028 79902 51504 54931 9692 60528 112858 93587 115708 113179 51002 84267 54482 348180 83480 51605 6396 79074 57122 10799 4927 51493 79897 23165 11102 10248 55746 10775 51637 10940 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly 5567 5568 335 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 3815 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis 55217 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response 6230 6232 6231 6234 6235 2197 8662 8663 140032 51386 3646 3437 6227 6205 6229 6207 6209 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 2261 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 5294 5781 627 3815 5594 207 5525 5526 5527 5528 5529 2322 3630 5880 4615 3082 1956 2549 374 90865 8870 9965 2252 152831 27006 6801 23533 5295 10818 3667 3654 79837 8660 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes 834 8738 355 8797 5875 27166 55367 79370 835 64065 10650 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism 10675 3074 2239 1836 176 221914 2719 9672 6487 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters 10613 5688 5689 5701 55788 335 5714 116085 2645 79902 9152 6530 6523 30061 553 6575 9843 5002 9056 10559 9990 11160 246213 6396 28234 57122 4927 1836 5717 23165 5718 55746 10058 55315 5687 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ 87 335 51706 7044 7123 5340 29789 350 94121 6403 3959 5660 23052 9948 813 7873 374354 3920 3479 5579 2243 3481 7273 1072 2266 7042 2244 967 3082 2316 1675 928 5175 5005 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling 23118 90268 5924 7186 84888 7124 355 8439 8797 56928 8737 7322 835 3065 836 6868 7132 330 142678 329 8767 81858 57580 7332 5664 9826 9828 22899 51107 29110 4615 387 55851 27018 445328 3654 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication 7027 891 7029 4998 84515 4999 23649 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression 23054 57761 96764 10025 133522 335 336 9440 2274 4520 7296 3992 1374 892 112950 9967 1581 9439 2101 9862 80306 405 51003 4199 376497 123 9915 1024 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors 2864 2865 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 79728 7486 580 9156 5932 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle 5295 8502 10818 5361 9352 22852 57216 1832 224 23592 5783 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome 5295 5781 1445 1956 2549 374 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication 201595 7341 335 746 10313 1603 4836 26986 84061 8672 2194 1977 3840 9532 10294 6185 6184 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 90268 11065 7320 29089 7322 55236 997 54926 7319 7332 7874 8239 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling 5295 8968 3575 3667 64109 3082 5896 8660 5897 3716 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants 2322 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis 1638 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation 160 51606 161 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint 891 8900 9133 9088 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling 23118 5688 917 7335 5689 5336 5701 5714 7454 7322 997 26191 5795 51466 5295 8945 8767 1445 5717 3115 5718 3113 3702 5687 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis 6396 57122 4927 5440 2962 5441 23165 79902 5436 55746 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate 51084 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 7027 1871 7029 5520 1021 898 1870 1032 1031 1030 1029 5753 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases 6421 2908 2034 387 1956 1796 1398 1793 55620 5753 867 207 898 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 5982 5983 5111 5984 25898 5985 6119 7318 6118 10459 5429 51455 9100 5981 57804 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants 3815 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis 5214 5210 5567 5568 2597 2645 79902 2821 2026 6396 5207 5208 57122 5209 4927 5528 23165 2023 55746 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 7846 7280 79861 10574 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures 4316 4318 1306 80781 1287 3691 9313 1286 1293 7092 4016 84695 5339 7837 649 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 29110 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway 3105 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels 5027 5025 6786 7225 80228 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors 2846 5032 5028 5029 53829 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste 50833 50832 50834 50837 50836 50839 50838 50840 6340 2782 6339 6338 133060 5726 54429 80835 255022 259289 259287 259286 259285 259293 259292 259290 83756 259296 259295 54795 50831 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 6868 182 3714 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type 326625 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis 5476 4758 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling 3908 5747 3082 3913 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand 54386 6119 7486 6118 5111 7014 57804 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling 2049 28964 2047 2050 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 867 5781 7297 3716 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 5594 6997 4838 91 199699 7044 9350 4089 2657 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation 8968 8347 3018 8348 85236 3014 8370 3021 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism 5300 79902 3716 8672 23586 7318 1977 6396 3840 57122 4927 23165 55746 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions 4496 84560 4501 4502 4520 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) 9630 5594 2782 408 2785 59345 2783 2151 2147 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling 5594 829 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 176 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling 3560 5295 3600 1437 50615 3558 59067 1438 3716 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane 23428 9056 10991 23657 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends 54386 8347 3018 8348 85236 3014 8370 7014 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 54386 6996 8347 4913 3018 8348 85236 3014 8370 7014 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway 4248 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t 5236 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters 116085 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 27018 5924 9828 22899 445328 51107 55851 835 57580 5664 9826 836 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 28512 28511 8737 4615 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC 254531 50487 11145 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly 7846 5520 7341 3930 25978 2010 79643 1104 51652 79902 23592 891 6396 7280 25909 57122 79861 9133 23165 55746 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family 4582 26253 5336 394263 4585 170482 727897 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 2252 27006 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease 5295 10818 2549 GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 9456 22839 9369 22941 57502 54413 127833 80059 143425 81858 55327 347731 347730 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 6575 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation 10584 5648 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 1009 1793 1499 998 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 5295 5294 2549 8660 23533 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis 917 5747 4651 4644 7454 10152 4627 695 1398 1793 644150 5594 3071 10093 10097 10163 10096 10810 998 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function 580 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane 196527 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification 90268 6996 10920 1642 5886 5887 7508 8720 2107 3065 10113 64344 6709 3018 85236 9100 339122 54732 80267 10206 56886 84447 51014 28952 7844 11014 79016 55757 10445 11236 55884 5476 29843 23363 22944 221143 90865 123879 79091 26094 399818 8883 54939 196483 80341 79269 140735 122416 140825 51371 22872 5715 5716 401447 728386 392188 5717 219333 5718 10868 1487 10869 51651 8239 5687 91833 29761 5688 57646 5689 84101 10678 5701 100287327 8535 23358 5714 57695 335 336 80012 6304 7416 648 813 7528 55577 2673 5973 51005 330 348 329 8313 79947 4248 9978 4253 2218 10559 79147 113829 729920 120071 123624 23093 22846 23287 4061 79805 60509 284076 9646 10195 6396 57122 4927 23165 4089 55746 7518 9117 11196 23243 64689 5537 10960 79902 1639 79053 9382 51552 347527 23586 287 6710 7703 57731 3913 2200 23314 64856 54757 11098 3491 7184 54587 9331 3488 5591 3487 9810 92305 220441 9781 5193 11065 64284 84932 57111 8767 2243 4249 10825 79090 6482 2159 81876 2147 6484 2158 6487 2266 340075 23682 9037 4582 6480 394263 5199 5872 7058 5873 4585 256435 339366 9230 221981 727897 79875 81794 2719 80070 51399 122553 7109 84061 79728 10392 11282 55741 11320 4286 63967 6185 6184 23193 201595 3105 746 1603 55611 54764 55593 7280 6468 9097 10402 2034 387 374 55854 89978 51611 4733 408 285381 5878 7186 8737 7322 997 5423 64326 829 7046 154881 7320 338 197370 79677 8900 84961 7879 8924 51602 81849 7155 7319 54780 7332 23014 27252 1000 3630 25793 11275 54926 64410 26259 144699 79642 84727 146330 92591 140460 29089 80176 4193 54620 55236 53339 4869 326624 2801 7874 7486 7341 367 7421 9545 2908 5914 10401 5111 5875 5371 124872 580 9986 4758 3622 2350 9554 8295 23326 51601 349667 94005 81847 7512 390243 8607 146183 58530 8581 10020 146760 8655 251 80740 2822 1781 55650 1048 51299 54872 6975 1778 7007 10232 1453 84992 10026 8945 221656 360226 55860 2650 10121 192134 55568 117248 7846 7419 50614 10540 57452 64409 79623 23275 84197 3895 10970 9510 286 256281 8766 4121 57171 29926 197258 51272 57511 84342 9958 10254 25879 22796 9609 8370 5931 9367 8347 4221 9126 10735 8348 8204 3054 64708 50813 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation 5931 10000 207 5371 5300 208 79837 3622 3065 84289 54815 64769 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway 7099 7186 355 1630 8797 8737 23643 836 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 8660 PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair 4482 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 5245 22808 5501 5604 5605 4296 5525 815 816 5526 817 5527 818 5528 5529 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors 335 338 922 6280 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors 338 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 928 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 10613 11160 5688 5689 5701 55788 335 5714 5717 5718 10058 5687 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) 2244 7099 23643 4615 2243 695 6271 6280 2266 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 23118 7099 7186 23643 5594 5604 1432 8767 2243 5528 1326 4208 2266 2244 7335 28512 9097 57162 28511 4615 3725 695 6280 10392 51295 8945 3654 6271 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 5275 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 7027 5594 7029 892 4221 4089 3065 1030 1024 22938 8239 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation 154743 57761 6129 6230 9681 6232 6141 6231 23334 6234 6146 6235 523 2197 140032 10312 8894 23677 1968 6227 652968 51606 6229 9296 79726 6156 6159 11224 6168 6169 6160 6124 6130 6170 6396 245972 28956 6205 6207 6209 10641 64223 6128 729438 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling 23118 7335 3725 3605 112744 5594 10392 5604 1432 64806 8945 8767 3654 5528 1326 4208 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination 5886 5887 367 55611 54764 55593 23586 3018 85236 9100 580 9986 8295 23326 9097 81847 8607 10445 387 90865 408 221656 401447 728386 392188 219333 5717 10868 5718 10869 51651 91833 5687 8239 29761 5688 57646 7419 5689 7186 84101 5701 100287327 23358 8737 5714 57695 5423 7416 7528 7046 330 329 8767 8900 8313 9958 10254 10392 8347 8348 4193 3054 63967 4089 7874 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 64682 5688 11065 5689 10393 51343 5701 5714 5717 5718 246184 51529 5687 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events 5567 5332 5568 2771 10645 9630 5594 814 815 816 10768 817 818 5573 5136 5576 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 22894 23404 54512 167227 51013 7538 118460 5393 11340 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction 8911 58498 8912 7170 140465 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling 10000 2771 5440 10728 5441 3021 3065 7528 858 5594 2782 3018 85236 207 2785 3014 59345 2783 8877 4316 5747 4318 3725 8370 1956 208 374 5481 1903 6801 8968 5295 4602 8347 9126 27327 10735 8348 2288 23028 8204 23030 2962 7031 5436 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 5295 10818 5781 2549 GSD II%REACTOME%R-HSA-5357609.5 GSD II 2548 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism 125061 169355 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus 6396 57122 4927 23165 79902 55746 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants 5906 2244 5594 5604 5605 408 2243 1445 54518 283455 2266 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling 10728 405 9915 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination 25888 11051 6636 8106 6635 51585 6637 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels 79054 1179 9311 219931 7809 1831 10110 6340 94015 23678 53373 6339 55515 6338 40 196527 2040 1186 1185 1184 1183 7225 1182 1181 54795 59341 133308 1180 55503 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions 9037 23129 5361 5362 5365 8482 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA 6996 CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) 5688 5689 1728 5701 5714 4947 5717 5718 5687 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 387 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 5423 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle 22999 10815 6572 8499 2744 4128 9256 55327 7915 8541 8497 27165 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation 5931 2966 404672 79101 7343 54700 5440 5441 2071 3065 54815 2967 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion 51335 54931 9692 60528 3028 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide 760 759 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling 27018 835 836 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants 2322 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 10038 6996 10920 1642 5886 5887 7508 5440 5441 2966 51750 4913 3018 85236 3014 9100 2140 322 2967 10445 4255 5717 5718 5687 5688 5689 5701 5714 8505 5423 7528 56949 7320 64421 79840 27343 8900 8924 51567 9978 5932 55215 25898 6119 6118 8178 2176 2187 29089 22909 9937 5436 7874 7518 545 57461 7486 5982 7341 5983 10401 9156 5111 5984 5985 7318 5883 83695 580 51008 7014 54386 84164 8607 2138 10721 5429 10459 51455 23030 5591 5531 8370 2071 80198 146956 79008 197342 79728 404672 8347 8348 63967 5981 64708 50813 57804 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 3791 51411 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 23118 5295 6868 348 51107 55851 1956 5664 2562 83737 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism 340075 53947 5476 5660 6609 427 4074 3074 79642 347527 2583 81849 9331 7368 10825 4758 64781 6487 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death 10000 3002 25978 3009 79643 708 3007 3006 51652 4836 6709 5317 22900 79792 11140 5339 7027 834 5747 7029 1630 57162 8655 140735 5717 5718 1499 5687 5688 7099 5689 7186 355 5701 8797 8737 5714 23643 6304 1832 836 5594 330 207 329 7332 83737 208 4137 63967 10015 1687 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 3030 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling 3815 867 10019 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 836 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 7027 5688 5689 7029 5701 10000 5714 208 5753 91750 207 8900 898 5717 5718 5687 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G 5688 5689 5701 9978 5714 5717 5718 5687 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors 553 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 1208 8513 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 7296 6648 1536 1535 2882 475 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex 6119 6118 51053 4998 84515 4999 8318 23649 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 10559 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 5295 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly 5567 344 5568 341 345 335 348 338 336 4547 337 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA 25888 11051 6636 8106 6635 51585 6637 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL 3030 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 28234 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 51171 1585 83930 1584 3290 9256 10948 231 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 867 5295 5594 10818 5781 53834 2549 161742 200734 27006 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 57461 1642 5982 9978 5983 5440 5441 2071 5111 5984 56949 5985 6119 404672 2966 6118 5981 5436 7874 57804 2967 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants 3002 1639 3065 5551 5594 29851 7297 53335 5573 9978 57674 3725 4627 597 7170 3092 1937 6801 5295 891 238 10818 3667 22872 2305 4193 9648 4869 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels 3762 2782 3766 9568 3760 2785 59345 2783 3772 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 283375 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 83439 891 3065 1499 1029 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 10540 9117 11196 23243 64689 5537 10960 829 1639 9382 10113 6709 286 287 6710 79090 57731 81876 9554 51272 54732 57511 4253 3630 84342 22796 51014 11014 374 8655 51399 1781 122553 140735 7109 1778 6396 22872 1453 55860 2801 10121 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA 26147 100170841 8370 3021 2146 8968 5931 8347 3018 8348 85236 3014 121536 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth 5621 5594 8911 5747 6709 1286 8912 2668 6710 1293 57731 1287 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 5594 5604 5605 5781 7297 11221 3716 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors 59350 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex 6749 5440 5441 2071 6830 27125 9646 404672 4300 2966 8178 2962 5436 2967 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis 6319 60481 47 9524 2194 2181 22880 79071 5538 9200 64834 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism 80704 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends 545 7486 5982 5983 8370 9156 5932 5984 5985 6119 6118 8347 5883 3018 8348 85236 5531 83695 8900 63967 3014 8924 580 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors 5732 5733 5739 56413 10800 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy 100188893 7335 7419 29110 7322 7416 9927 7332 9474 54543 55669 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization 2324 3791 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion 2158 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 374 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency 162417 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 7474 160 161 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination 100 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) 116138 8720 1639 5393 11340 10113 22894 2673 8894 23404 54512 27230 1968 167227 2081 51013 81501 90993 118460 5526 10488 30827 84447 10897 22872 7184 3576 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 5688 5689 5701 9978 5714 50937 22873 408 374654 5717 5718 83737 6608 5687 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 10020 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways 2633 6396 3840 57122 4927 23165 79902 8106 55746 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle 87 5930 29766 9352 7919 4646 11329 11140 10574 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 54207 3776 50801 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 5984 10038 5985 6119 6118 5982 5983 8505 5423 5981 5111 57804 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant 2159 2158 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation 891 4998 84515 4999 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 55584 1141 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT 3815 867 5295 4318 5781 7006 10019 1215 10750 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome 403314 339 10930 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor 57554 5924 815 816 817 818 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription 2908 30818 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type 10675 2239 221914 2719 9672 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling 3560 3600 3716 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins 6996 7486 8535 7341 7508 367 7421 80012 2908 5914 6304 10401 79902 3065 648 5111 197370 79677 8924 51602 5371 7155 54780 3622 7703 8370 23314 6396 9126 4286 10735 57122 4193 4927 8204 23165 4869 55746 1487 7518 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes 4615 8767 3654 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol 6129 6141 10200 6146 51504 22803 6156 6159 6168 6169 6160 6170 1453 6230 6232 6231 6234 6235 2197 5393 11340 140032 22894 23404 54512 6227 51013 6229 51602 118460 11224 9136 10171 79050 22984 25879 9790 27341 10813 55226 51077 54555 84128 6124 11056 55813 55505 92856 51118 1736 6130 6205 6207 10799 79897 26354 11102 81875 6209 55781 51388 10969 6128 705 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression 27327 2908 30818 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) 6390 57128 644096 10131 4967 23530 3420 3418 4191 6391 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis 2583 53947 81849 9331 7368 64781 6487 FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants 867 2322 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation 207 51070 4836 6697 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation 5328 5049 5795 10396 427 10312 1536 1535 6709 4125 29108 6278 5476 387 6037 6280 2495 3071 5878 4257 5657 5717 5718 5315 54509 5689 10288 5701 27180 5236 6993 290 5906 51071 5594 1432 22875 54472 7879 80301 2548 2352 11314 124583 388697 967 10326 83716 127829 10493 3684 3240 2799 51411 5787 5547 1675 353189 28956 57826 170482 4033 55313 5005 326624 3417 6590 5273 5036 29952 154664 5834 9545 5836 8566 10394 9342 8895 3916 51552 1460 3920 3074 51719 47 5317 161 3608 84418 79792 1992 4758 10855 272 8904 57153 6947 2444 719 8655 1778 178 55860 1512 57554 55276 1832 1511 5660 2821 10970 51125 10097 5645 4318 5199 5873 196527 2040 3685 10788 84061 2171 23200 5175 5269 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 9630 2864 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 64682 5688 11065 5689 10393 5701 5714 8900 5717 5718 246184 51529 5687 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 10058 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 3815 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly 81025 127534 57165 2703 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants 2322 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN 147945 29110 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 142678 182 4192 51107 55851 57534 5664 3714 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 116085 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea 9750 3781 129446 161497 10518 4627 55584 2059 5962 64072 4647 286262 494513 6709 3779 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression 8968 10514 79101 8347 3018 8348 85236 5440 3014 5441 8370 3021 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 79728 7486 580 9156 5932 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy 51422 100188893 7419 25978 7322 79643 51652 7416 9927 53632 1460 1457 115201 60673 7332 9776 64422 84971 30849 7335 11345 29110 2034 8655 1781 140735 11337 1778 7249 28956 64223 123 9474 55669 54543 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors 57554 116444 815 816 55327 817 818 116443 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity 814 3930 27327 815 816 817 818 3065 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases 1992 79792 836 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 5688 5689 51343 5701 5714 8945 5717 5718 5687 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants 238 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters 1468 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System 2244 7099 23643 4615 695 6280 3818 51284 2243 2161 6271 81622 2147 2266 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity 5688 2101 5689 5701 9978 133522 5714 2908 4488 5717 5718 5687 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion 11004 6232 80776 79902 25909 5525 5526 23063 5527 1063 5528 57551 5529 83540 1058 79019 2491 5501 8655 1781 140735 891 348235 1778 25936 6396 9126 220134 10735 57122 9133 81930 10726 55746 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME 9153 4830 7498 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 6801 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase 5520 7341 80776 25978 79643 1104 51652 79902 7280 5525 79861 5526 23063 5527 5528 57551 5529 83540 2010 5501 2491 8655 1781 140735 891 1778 25936 9133 81930 5717 5718 10726 246184 51529 5687 64682 5688 11065 7846 5689 10393 11004 5701 6232 5714 23592 25909 1063 1058 79019 3930 348235 6396 9126 10735 220134 57122 23165 55746 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress 22894 23404 54512 167227 51013 118460 5393 11340 3576 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation 57554 815 816 817 818 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 553 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling 5567 5568 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 51422 9882 5872 4644 79058 9847 4627 208 53632 51552 6517 23265 207 8766 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex 30849 25978 79643 51652 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 5295 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress 545 5982 5983 84515 8318 5984 5985 6119 6118 5883 63967 4998 4999 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3815 29028 4605 7341 348 5308 1956 79047 10765 4869 284252 7528 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 6873 2962 54457 5436 2967 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence 54386 3009 3007 8370 3006 25842 8091 8347 3018 8348 85236 8900 3014 898 7014 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair 10038 545 1642 7486 5982 5983 7341 9156 5111 5984 5985 51750 5883 3018 85236 83695 3014 580 2140 322 2138 10721 5429 23030 5591 5717 5718 5687 5688 5689 5701 5714 64421 79840 27343 8900 5531 8924 51567 9978 8370 80198 146956 5932 79008 197342 79728 6119 6118 8347 8348 63967 5981 7518 57804 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle 22999 10815 8499 4128 9256 8541 8497 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling 5567 5568 5573 5576 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C 64682 11065 891 10393 246184 51529 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells 5460 9139 10630 79923 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) 5688 50489 5689 5701 5714 5717 5718 5687 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism 3145 28234 7389 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 8968 5931 8347 3018 8348 85236 3014 8370 3021 3065 54815 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 10038 57461 10920 1642 5886 5982 5887 7341 5983 7508 5440 5441 10401 5111 7528 5984 56949 5985 2966 2967 9978 8607 10445 2071 6119 404672 6118 8178 5981 5436 64708 50813 7874 57804 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation 2252 27006 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 23476 7004 7005 3725 2034 8370 3021 8463 2146 83439 8968 5931 8347 3018 8348 85236 3014 1499 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation 2160 2158 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling 5567 5568 2782 2771 2852 2785 59345 5573 2783 5576 2781 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis 5982 5983 5111 5984 5985 6119 7318 6118 5429 51455 9100 5981 57804 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 54872 84992 55650 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus 6396 57122 4927 23165 79902 55746 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 2239 221914 2719 9672 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 27166 10650 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER 10038 10920 1642 5886 5887 9978 7508 8607 10445 64708 7528 50813 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA 5520 2107 5440 65110 5441 3028 2935 2966 2967 51335 5717 5718 10523 5687 5688 5689 5701 57794 5714 22827 5393 8741 11340 26986 56949 22894 23404 54512 6638 1432 167227 51013 10594 207 10236 7538 118460 23524 10465 51639 8896 51645 6124 24148 6130 6396 85313 57122 79074 10084 4927 10799 11051 51493 2962 79897 23165 11102 5436 10248 10775 55746 51585 51637 6128 10940 57461 55006 84844 6129 56259 25821 79693 6141 9360 6146 79902 51729 25888 6156 6159 6168 6169 6160 6170 103 104 403314 339 10930 84081 6631 10929 6230 11066 6232 10772 6231 56339 51691 6234 84950 8899 6235 9129 10073 151903 2197 55660 143884 23759 5411 23398 140032 63932 60625 6227 79622 54931 51634 9692 57819 6229 8559 60528 58509 51759 11017 6636 6635 6637 6205 6207 6209 8487 11218 23211 96764 1797 124245 10200 91746 51504 22803 22938 9785 199746 7919 9984 79228 84321 51602 3181 6627 93587 115708 113179 51002 84267 57472 54482 348180 83480 9125 51605 29883 3178 112858 8106 1975 1977 1453 23381 23293 11224 9136 10171 79050 5930 22984 25879 9790 27341 10813 55226 51077 2071 54555 84128 11056 55813 55505 92856 51118 1736 404672 10128 25996 87178 26354 81875 55781 51388 10969 705 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab 11140 55914 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants 2322 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm 7004 3170 8463 1499 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria 10000 207 208 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 388585 10046 2208 142678 182 4192 3002 51107 55851 57534 5664 3714 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand 6119 6118 23649 5111 57804 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 376497 28965 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity 9900 127833 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 2966 404672 5440 2962 5441 2071 5436 2967 HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation 2239 221914 2719 9672 10855 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d 10195 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation 335 336 8720 3895 813 10970 338 348 2243 3913 2266 1000 2200 2719 80341 64856 11320 54757 10232 4221 11098 3491 7184 54587 3488 3487 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions 1006 1009 64403 1499 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase 5747 3009 3007 1832 3006 6304 836 6709 5317 329 4137 63967 5339 1499 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 23054 56938 96764 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling 23118 5688 3554 5689 7186 5701 5714 5604 54472 8767 1326 7335 28512 9097 57162 9978 28511 4615 7850 10392 8945 3654 5717 5718 5687 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression 79101 7343 5440 5441 8370 3021 2071 3065 79595 8968 404672 2966 8347 3018 8348 85236 3014 79685 8819 29115 2967 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins 80149 3224 3609 6615 1006 27327 1009 64403 1499 28513 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers 10000 3002 5440 5441 3065 892 22938 10046 84447 3725 5880 3082 2549 374 8546 1937 9965 613 2252 152831 27006 6801 23533 867 84335 408 7249 22872 2305 1445 3791 5717 57534 5718 1487 8660 283455 1499 5687 5688 8322 5689 5701 8323 388585 5714 22808 22943 627 2261 11221 10014 54518 5551 7046 55733 5906 5594 56829 5604 5605 142678 207 7750 53335 5573 9978 57674 4627 597 3092 161742 200734 51411 4763 11160 399473 57085 815 4193 816 817 2962 818 9648 4869 4089 5436 64223 54845 83999 5294 1639 3714 26127 5525 29851 5526 5527 5528 5529 11140 79109 55914 5245 2322 182 5501 1956 5295 238 891 10818 3667 5781 3815 6868 4296 2243 7297 5664 2266 2244 51107 7170 55851 208 1185 1024 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 9630 1460 2782 1457 5082 2785 59345 2783 10574 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo 23286 836 9113 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation 7042 8076 10516 2006 2201 4016 2200 3685 84695 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis 57128 150274 51218 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 23118 6868 348 51107 55851 5664 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression 47 2194 32 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling 7186 9097 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors 5594 1432 3725 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins 5688 5689 5701 1407 9978 5714 8945 5717 5718 5687 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 2049 2047 2043 4318 160 161 51107 55851 2044 5664 2050 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 5730 145482 873 10728 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation 3178 6631 84844 10929 57794 10772 5440 5441 22827 55660 22803 6638 10236 3181 23524 6627 5930 51639 6636 8106 6635 6637 199746 2962 11051 5436 51585 10523 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 8370 1956 79902 8655 1781 2146 140735 8968 5931 1778 8347 6396 3018 8348 85236 57122 5371 4927 23165 55746 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib 11140 55914 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions 5781 5175 3685 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 22999 10815 8499 2744 9256 8541 8497 27165 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 2158 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency 1585 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 917 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism 6898 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification 9630 1432 2782 2771 5028 2785 59345 2783 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate 27159 278 GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation 3762 2782 3766 9568 3760 2771 2785 59345 2783 3772 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 594 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling 23163 3082 2549 1398 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription 4089 463 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking 10920 5049 23299 636 10000 22836 10113 6709 4646 23647 917 339122 6293 54732 55850 122830 84316 51014 60561 11014 7164 374 9026 130340 8546 388552 2495 6272 140735 867 2647 55330 54885 408 7249 23046 22872 9829 55582 5878 30011 64837 81930 29127 113220 8322 3833 7474 11004 127833 10749 829 8867 6517 338 207 7879 9882 3630 4253 3575 273 79058 4627 9847 3092 2799 4074 6396 9648 2801 51422 93343 2060 4644 9117 7251 11196 25978 51271 23243 64689 79643 5537 51652 10960 1639 9342 9382 51552 53632 160 161 287 6710 57731 9554 1956 8655 1781 1778 1453 55860 10121 8301 10540 8906 23265 10093 286 10097 8766 10096 23048 22878 4121 79090 54453 81876 2664 57465 23163 23682 51272 11345 57511 27128 201627 84342 5872 10254 6764 22796 5873 9609 9230 414918 54662 9909 208 79961 81025 127534 26000 51399 57165 2703 60684 122553 7109 84079 9367 11337 6572 29978 84313 143425 64708 50813 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins 23118 5778 146433 834 28512 9097 2208 4128 57162 50615 28511 4615 3725 3082 79923 90865 1398 867 5657 1438 5717 5718 998 8660 5687 5688 5689 3554 7186 5701 7124 5714 3596 10538 6348 829 5594 5604 9180 7132 1432 9244 10148 54472 207 4843 26095 3181 3595 3594 1326 4208 3593 3592 1072 27250 6627 3560 6648 9978 3575 5771 3588 3684 8809 3597 5896 5897 7850 64109 163702 6364 29949 3576 6367 53832 7006 3558 29760 282618 3600 64806 79792 5528 3313 5295 3667 8945 59067 7184 1437 5781 3977 1511 5783 836 3716 8767 7297 759 4312 7335 4582 4318 29110 3605 8968 112744 10392 6888 3654 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 5308 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects 64682 7027 11065 1871 10393 7029 51343 1021 898 1870 246184 51529 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi 4121 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 10613 51422 23476 5688 5689 7004 201595 5701 7005 5714 746 1603 3021 8463 80380 3716 53632 1460 1457 3018 142678 85236 3014 9978 3725 2034 8370 2146 11160 84061 83439 8968 5931 8347 27327 8348 8945 5717 5718 6185 1499 6184 5687 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation 51021 84545 51649 122704 9553 64981 10240 3396 118487 51373 740 51650 51253 54148 55037 9801 219927 51116 29074 65003 51081 6150 28957 57129 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling 7297 3594 3593 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 6119 6118 9156 5111 57804 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling 5906 2244 5747 207 2243 1445 1398 54518 2266 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation 6618 6617 5440 5441 55290 51728 661 11128 2976 10621 2971 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism 11218 96764 10073 79902 6636 6635 6637 6396 57122 4927 23165 8487 55746 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism 30849 55300 81544 5294 3631 9107 126282 8867 4534 284161 5783 23760 23533 51552 5295 5287 9110 79837 22874 9108 22876 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling 5924 9828 22899 51107 4615 387 55851 835 3065 836 27018 6868 445328 8767 3654 57580 5664 9826 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers 55193 53335 55274 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 51422 1337 10000 208 1339 9997 1350 2821 53632 7296 1345 2744 7249 27327 28956 207 2539 64223 613227 27165 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition 51451 891 5520 51343 2305 8900 9133 9088 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals 4496 84560 4501 4502 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle 81624 3930 2010 4722 23592 1793 3895 10788 5295 398 4162 4296 7879 57580 4983 55914 998 11135 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control 51021 84545 51649 122704 9553 64981 10240 3396 118487 51373 740 51650 51253 54148 55037 9801 219927 51116 29074 65003 51081 6150 28957 57129 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins 7296 9900 5604 5605 127833 928 10015 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL 5688 5689 5701 9978 5714 51339 5717 5718 5687 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) 6367 51554 7253 122876 2492 4295 129521 2151 23566 56413 2865 1133 6866 5032 94233 885 5028 5029 84432 1902 6375 57121 150 2922 4828 10800 9038 3362 611 2846 3350 9170 10887 623 624 53829 2832 719 2831 1903 3792 2852 2859 5739 2587 5732 5733 8862 9283 6348 23596 9290 9294 5660 59350 1325 2532 5368 2847 553 2147 4852 2864 1816 1815 6372 6364 6357 3576 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) 10559 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses 2799 NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response 5688 5689 1642 5701 9978 5714 580 5717 5718 5687 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants 22808 5501 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion 103 104 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement 730 735 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 55315 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) 5105 348 55290 9997 9646 11051 51585 51422 7257 2976 2971 2821 7296 112950 3930 11022 4603 2744 51728 661 11128 10621 2539 2538 834 83439 4602 7249 2623 161882 283 6648 5300 79370 57060 117584 7832 84289 10650 5932 57472 55215 6119 6118 9125 2176 28956 4193 144455 204851 29883 4869 64065 64223 7874 8445 545 5325 25946 7486 5982 5983 7341 367 133746 79733 7421 27166 2908 55367 5914 5457 835 9156 5111 64769 53632 1460 5984 5985 8738 91875 5883 64216 1457 7978 54971 5875 84649 83695 5371 580 112858 3622 79109 133383 11343 51755 23175 1956 6830 27125 891 4300 55193 84962 10765 55835 3815 9862 6871 285676 1020 8370 2071 55689 26993 51003 2146 197320 8968 5931 404672 8347 4221 8348 22880 3054 25799 79685 84911 8819 123 29115 1024 23054 6996 6319 60481 10025 133522 113835 7343 5440 5441 23067 3021 3065 9440 79595 7581 63924 91272 10514 2966 892 3018 85236 2167 5579 3014 54934 11168 9439 121536 54815 54737 2967 22822 30827 26147 100170841 79101 51230 79862 7700 10445 4781 6741 5717 5718 1499 5687 8239 5688 5689 5701 8535 5714 4094 80012 648 10014 7528 1432 207 4208 30818 83737 728957 168374 5816 29028 155061 117581 4605 9978 5275 121274 29959 79088 54487 84671 4852 284443 6910 65123 7582 57508 100289635 1482 23248 163255 54973 23269 25896 6929 6618 388567 6617 8178 814 55726 815 6873 79035 816 817 818 2962 22869 54457 4089 5436 9534 1493 284309 100131980 283337 6749 22835 6883 10172 6882 7004 6884 7005 1021 84914 3558 57541 147741 2103 90594 90233 6877 6879 8463 1030 51333 26974 65988 79230 25888 339327 26053 353274 57209 286075 5527 181 126068 7703 50943 163081 7712 442319 7711 147949 57474 91120 80110 182 390927 3172 221044 4336 5308 23429 1876 84626 51385 23660 171392 7738 7753 441234 23314 144348 7625 7627 114026 27327 84527 4488 6046 7757 8861 90874 79047 284252 162972 246184 148213 148203 51529 1029 148206 64682 7769 11065 80032 374928 10393 148103 51343 126231 1437 140612 5781 10432 3977 349075 163049 163051 463 163050 654254 84775 7549 60528 208 6636 6635 6637 3654 10000 898 22938 7027 7029 144233 10046 57510 4854 3725 355 8797 627 2645 5594 8900 1337 3630 1339 1350 1345 27165 2101 23405 8106 613227 54700 405 79837 9915 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria 8655 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling 3667 8660 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation 54988 10249 341392 389396 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency 594 10295 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 29110 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms 7474 1535 8324 3725 10811 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants 2322 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 7784 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR 6119 6118 9156 5111 57804 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 1558 1565 4056 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) 2244 7099 23643 4615 2243 695 6271 6280 2266 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand 51284 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 53335 55274 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling 5295 5567 10818 5568 220164 2668 5781 2549 1796 8660 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins 55568 117248 4582 10678 50614 394263 57452 6480 64409 79623 4585 256435 727897 9331 6482 6484 2650 6487 192134 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation 23630 3784 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses 23586 9978 3449 7297 3443 3441 3439 3716 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria 549 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 4854 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization 5336 5532 7006 10768 695 3702 7294 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA 22822 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation 84693 10449 641371 84320 134526 3030 51102 23597 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells 5688 5689 5701 5714 8945 5579 5966 5717 5718 4794 5687 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 144233 57510 5440 5441 283 54487 8370 3021 23405 8968 11022 7257 8347 4603 3018 8348 27327 60528 85236 3014 5436 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI 79143 11145 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs 5594 3716 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction 7140 4607 7139 29766 7111 7137 7170 7273 4635 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR 94005 10026 CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport 6517 154091 6523 6527 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 344 345 335 348 338 336 8720 4547 337 1071 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase 5520 7341 80776 25978 79643 1104 51652 79902 7280 5525 79861 5526 23063 5527 5528 57551 5529 83540 2010 5501 2491 8655 1781 140735 891 1778 25936 9133 81930 5717 5718 10726 246184 51529 5687 64682 5688 11065 7846 5689 10393 11004 5701 6232 5714 23592 25909 1063 1058 79019 3930 348235 6396 9126 10735 220134 57122 23165 55746 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6129 6230 6232 6141 6231 2107 6234 6146 6235 2197 2935 26986 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors 6367 51554 8862 9283 4295 6348 129521 5660 2151 59350 1325 2532 5368 6866 2847 885 84432 6375 2922 553 2147 4828 10887 623 624 2832 719 2831 4852 3792 2852 6372 6364 6357 2587 3576 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses 147945 11277 197358 29110 5591 6737 115004 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins 8535 7341 80012 8370 6304 79902 3065 648 23314 6396 57122 4927 23165 7703 55746 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome 5027 834 29108 10910 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 5931 133522 23090 4089 3065 54815 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 9843 30061 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex 2966 404672 5440 2962 5441 2071 5436 2967 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 3815 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction 335 5158 336 145226 337 6121 131890 9626 4836 344 2782 345 338 348 5957 221914 10170 9672 1208 8608 611 2239 5475 54884 4647 2719 50700 5145 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 55788 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle 54509 5295 1730 87 81624 4162 10160 7879 26049 23380 29843 55971 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA 3065 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation 5931 133522 23090 4089 3065 54815 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases 51451 5520 3161 22822 1871 728642 9662 8655 7840 1781 22995 22897 7283 891 1778 91750 54930 84962 2305 1453 8945 11190 9133 27229 23354 114791 5717 80254 85378 5718 121441 55755 10806 10121 5687 5688 55835 7846 5689 8636 10540 5701 51343 5108 5714 84131 4957 9088 8900 1063 9978 4605 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway 5594 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade 2782 5158 5957 5475 131890 9626 4836 5145 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions 3897 23428 9056 481 23657 483 9123 6693 4312 23759 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis 3145 7389 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 5567 5568 10266 5586 2782 2324 207 5029 2785 59345 5175 3791 5573 2783 5576 79109 64223 59341 1499 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation 27232 4967 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis 8322 10920 7474 2060 8301 127833 8867 10093 160 338 161 10097 10096 23048 917 3575 273 10254 1956 9026 374 3092 867 4074 6572 29978 143425 408 9829 5878 30011 64708 50813 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 5816 3930 4336 54487 627 3065 814 27327 815 816 817 818 3654 4208 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 51422 1432 53632 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System 28964 22865 2752 2771 1312 1141 2782 84631 94030 5789 5579 2785 84189 4646 3745 59345 2783 3784 8541 8497 22999 10815 8499 51305 4128 9424 10089 26050 5924 127833 54207 3776 50801 10368 5594 81858 5573 5576 5567 5568 10313 781 774 814 815 4193 816 817 818 51422 220074 3790 53632 3782 160 7915 27345 3779 27165 3781 10645 3760 2900 2743 55327 200909 2901 200959 3772 2562 2557 347731 116443 347730 57554 9456 22839 1144 9369 116444 3762 22941 57502 3766 54413 9568 2570 80059 2569 55584 4900 8001 7881 81033 3755 3788 3746 9196 26251 9256 9495 6572 2744 143425 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse 917 26191 3115 3113 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 6996 4913 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine 54386 8347 3018 8348 85236 3014 8370 7014 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR 6868 51107 55851 5664 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination 8322 8323 284654 8549 59352 84133 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 6575 115019 1836 6561 6574 6508 9990 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors 6319 10000 2771 5440 80820 1071 5441 5914 3021 3065 2782 3018 85236 2785 3014 59345 2783 8877 5747 3725 1956 374 1903 5481 55818 6801 5295 4602 2194 27327 221656 23028 23030 5105 10728 7528 5594 858 344 341 348 207 10170 195814 57665 1381 8608 4316 4318 8370 208 127 8968 2172 8347 2171 9126 10735 8348 2288 54659 8204 2962 7031 5436 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events 5332 2771 129521 23566 9630 2782 2785 10768 59345 1902 5528 2783 57121 5136 150 2781 26575 611 9170 623 50835 624 53829 10645 2832 719 2831 26166 1903 84152 338398 85397 2852 83756 63940 2587 50831 50833 5733 50832 50834 8862 50837 26086 50836 2918 50839 9568 9560 50838 9283 5532 259294 2780 23596 50840 9290 9294 5660 1325 353164 5368 5594 2847 5573 5576 5726 5567 54429 5568 80835 1020 4852 259289 259287 259286 259285 814 815 816 817 259293 818 259292 259290 259296 1815 6372 259295 6364 6357 3576 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME 161823 5105 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle 64682 7027 11065 1871 546 10393 7029 51343 1021 1870 898 246184 51529 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT 83999 3021 3065 1460 1457 284654 3018 85236 5525 23401 51339 3014 8549 5526 5527 59352 5528 84133 5529 6658 8295 81847 8607 83439 7478 8945 5717 5718 1487 1499 5687 5688 8322 5689 7474 5701 8323 5714 22943 207 8313 9978 8370 208 6422 8968 8347 4221 8348 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 891 91754 9133 10783 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry 7027 5688 5689 7029 51343 5701 10000 5714 208 5753 91750 207 8900 898 5717 5718 5687 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 5295 5336 29760 10768 30011 695 6786 80228 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants 5525 5526 5527 5528 5529 1499 GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib 2542 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions 28231 11309 6567 353189 28234 53919 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis 5328 6281 5271 51706 481 2771 483 5680 9123 6693 6403 5583 3021 6543 51744 2151 914 6546 3065 5670 490 5671 491 5673 9630 2993 8525 5669 2782 5028 5579 2785 139189 59345 7273 2783 6786 80228 5027 5747 5336 5880 3082 747 85440 1607 387 1398 1793 23533 4602 408 23046 55582 23764 23028 4267 64837 5657 928 1445 10019 81930 7225 2623 29127 998 5739 55669 113220 3833 11004 87 8165 8797 64145 120425 161882 335 7044 23414 7123 10749 29789 10362 350 51317 94121 829 9927 3959 23052 54518 9948 813 7873 5906 374354 3479 5594 1432 338 207 4843 5573 5576 1072 5567 23428 5568 967 9056 23657 3684 1675 4072 5005 5294 3920 3897 5525 5526 3481 5527 10846 5528 27345 5529 5136 11343 150 50940 3779 5025 6609 1048 5295 8832 5781 5340 3441 5660 3818 3439 23759 5197 2243 2161 2160 221914 5270 4312 2159 9672 2147 2158 2266 7042 2244 2239 3449 196527 10630 1020 3443 80739 2719 3685 2316 3705 8968 5175 7010 51378 5269 5327 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex 5525 5526 5527 5528 5529 HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 23054 50488 9448 154743 9681 116138 8720 23334 3009 3007 3006 3021 4217 25842 9361 10113 64344 23677 27230 1536 1535 652968 3018 2081 85236 79726 8994 3014 2882 30827 84447 475 140735 84335 22872 5717 5718 5687 5688 5689 5701 8535 5714 335 80012 5393 648 11340 2673 22894 23404 54512 1432 167227 51013 207 118460 79094 4208 9978 6124 6130 6396 4199 815 816 9532 57122 817 4927 818 23165 10294 55746 6128 6129 6141 1021 6146 1870 79902 1639 1030 6156 5526 6159 11331 6168 6169 6160 6170 27327 7184 246184 51529 1029 64682 11065 10393 1728 51343 6230 6232 6231 6234 6235 2197 140032 23373 7296 6227 6229 208 79728 7086 245972 6205 6207 6209 96764 10000 523 10312 9296 2539 898 7027 1871 7029 3725 2034 374 55620 5753 7099 64784 10743 23643 7322 829 8894 5594 1968 51606 338 8900 1337 6648 571 23657 1339 1350 1345 6119 6118 28956 4193 6737 64223 3417 3576 545 57761 367 2908 1460 1457 84181 7014 54386 3313 8655 1781 1778 84962 8945 55860 613227 10121 7266 10540 51182 27000 57805 9531 22824 116835 10728 81501 90993 10488 11224 23645 25994 8370 405 113235 2146 8968 5931 8091 10897 8347 8348 55466 2288 8204 6888 81502 10641 1032 1031 729438 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants 2322 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection 3178 57461 84844 56259 201595 22924 7251 7341 6141 746 5440 5441 1993 1603 9382 4836 51729 7318 160 161 3840 3018 80273 85236 57551 79109 22938 8106 5295 2194 1977 9785 199746 9076 1499 10523 7099 712 57794 8737 335 23643 22827 6993 26986 56949 6638 10594 10236 3181 221914 23524 9672 2147 115004 6627 30849 11314 7301 4318 2239 10313 51639 29959 8896 8370 51645 2719 24148 6636 6635 4061 6637 84061 8968 8672 9646 8347 8348 85313 815 816 9532 817 10084 55236 2962 818 11051 10294 5436 6185 64223 51585 10015 6184 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN 6014 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress 5747 5567 5520 5568 3685 10266 5586 2782 2324 207 5029 2785 59345 5175 3791 5573 2783 5576 79109 64223 59341 1499 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology 814 3065 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX 2159 2158 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism 79048 6129 6230 6232 6141 6231 191 6234 6146 6235 2197 140032 7296 6227 875 6229 22928 6156 6159 11185 11224 3376 6168 6169 6160 9255 6124 51091 27232 6130 6170 60678 6205 6207 6209 6128 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS 627 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages 3908 374 3913 2252 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli 5027 5747 5567 5520 5568 8912 3685 10266 5586 2782 2324 207 5029 2785 59345 5175 3791 5573 2783 5576 79109 64223 59341 1499 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching 5984 5985 5982 5983 5981 23649 5111 57804 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling 90268 7186 84888 7124 56928 8737 29110 7322 7132 330 142678 329 81858 7332 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 2966 404672 5440 2962 5441 2071 5436 2967 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion 5361 5362 1072 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly 23394 8968 8347 3018 8348 85236 3014 8370 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 51072 5295 10000 207 387 4145 208 1956 2549 11140 55914 5753 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 27327 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface 51248 475 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 145226 6121 10170 4647 50700 8608 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 7027 7029 23649 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes 1460 891 1457 64151 9133 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions 5295 5336 10326 284266 695 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 6883 6882 6884 5440 5441 2071 6877 6879 404672 2966 6873 2962 54457 5436 2967 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 7341 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling 11140 55914 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway 5778 3558 51114 6709 5525 6710 5526 5527 9986 5528 58489 57731 5529 51104 5747 5245 2322 2668 3082 5501 1956 374 9965 2252 152831 27006 5295 10818 408 3667 1438 1445 221002 5717 5718 8660 283455 5687 57554 5688 5689 5924 5701 10048 1437 5714 5781 22808 11221 54518 3716 5906 3815 5594 5604 5605 51125 4296 2243 7297 2266 3560 2244 9978 161742 200734 64926 153090 4763 399473 10156 28956 815 816 817 818 7010 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 5688 5689 1728 5701 5714 10000 1460 7296 1457 207 84181 2539 571 9978 23657 208 374 79728 7086 4199 8945 6888 6737 5717 5718 3417 5687 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells 11004 10540 5476 829 1639 8655 1781 140735 1778 7879 55860 64837 1512 81930 3115 8722 3113 3111 29127 10121 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 4821 4760 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 1407 1453 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression 79101 7343 5440 5441 8370 3021 2071 3065 79595 8968 404672 2966 8347 3018 8348 85236 3014 79685 8819 29115 2967 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 398 7879 4548 1445 2040 2631 GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation 5688 5689 2043 7004 5701 10683 5714 343930 3170 8463 22938 10046 79923 3975 5460 7849 83439 7545 4602 6615 5717 4089 5718 134701 1499 5687 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport 11046 116085 9123 6543 6546 9152 7781 55244 7780 115286 283375 146802 53919 28231 11309 57153 6567 6548 284111 115019 154091 6527 6561 6574 1317 6248 83733 28234 1836 51248 376497 55315 28965 222962 9153 23568 8884 345274 6550 6517 389015 6549 51000 6530 133418 6523 30061 6575 9843 23428 5002 9056 10991 23657 10559 80024 6508 9990 1468 246213 353189 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling 28964 5747 2043 4318 51107 4627 387 55851 2044 2050 2049 2047 10093 160 161 10097 10096 4628 5664 1072 998 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation 91875 133746 4193 133383 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 898 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins 348262 5688 10009 5689 2060 23193 687 5701 5714 746 1603 3021 3170 3065 1460 5594 1457 3018 54971 85236 3014 7750 54737 117581 11171 8370 9159 2146 8968 5931 6929 6615 8347 27327 8348 4193 23028 5717 5718 6185 1487 1499 5315 93986 6184 5687 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA 6396 57122 4927 1104 23165 79902 55746 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) 3930 6309 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 7027 7029 5931 23269 80012 23429 1876 7703 648 2146 5932 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling 1630 7225 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 5688 5689 1432 5701 9978 5714 8945 5717 5718 5687 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development 814 3065 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm 5688 5689 2043 10046 5701 10683 5714 343930 5717 5718 134701 1499 22938 5687 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 90268 10920 1642 5886 5887 7508 8720 2107 3028 2935 8662 8663 51386 3646 1978 5464 9100 10440 339122 54732 80267 10206 56886 51014 84447 7844 55757 11014 11236 5476 22944 90865 221143 79091 399818 196483 51371 22872 5715 5716 401447 728386 392188 219333 10868 1487 10869 51651 91833 29761 57646 10678 84101 100287327 23358 57695 335 336 337 7416 813 348 79947 4253 123624 6124 23093 22846 23287 4061 79805 60509 284076 6130 9646 10195 4191 6128 6129 6141 6146 1639 79053 384 9382 51552 347527 6156 6159 65003 51081 150 6150 28957 57129 51021 84545 51649 122704 9553 6168 64981 10240 3396 6169 6160 118487 51373 740 51650 51253 7385 54148 55037 9801 219927 51116 29074 6170 10102 64856 54757 11098 3491 3489 54587 7184 3488 5591 9331 3487 9810 92305 220441 1755 9781 5193 64284 84932 57111 4482 10825 79090 81876 23163 340075 23682 5872 5873 9230 9255 51399 122553 7109 4286 2864 63967 51504 5029 4712 2922 8565 6897 7407 2617 2193 2695 1045 374 1937 55854 89978 51611 4733 285381 1361 5423 1363 829 290 1360 57393 3626 1359 2028 3479 8894 56605 1968 8890 1636 1967 197370 79677 7879 51602 7155 54780 1000 29089 4193 4869 7874 7486 7341 367 7421 27166 2908 5914 10401 56652 5111 1460 1457 5875 5371 3481 580 3622 9554 55176 8295 23326 8607 8655 1781 1778 1453 8945 221656 55860 1512 10121 7846 7419 10540 5340 1215 1511 3895 10970 9510 286 4121 4312 10254 25879 8370 8968 5931 9367 8347 4221 8348 3054 6996 3021 3065 9361 10113 64344 27230 6709 3018 85236 3014 28952 10445 79016 55884 29843 23363 123879 26094 8883 54939 80341 79269 140735 122416 140825 5717 5718 1499 5687 8239 5688 5689 5701 8535 5714 80012 6304 9027 648 9445 6653 23555 7528 55577 340348 26986 2673 325 5973 54959 51005 330 329 8313 4248 9978 2218 10559 79147 113829 729920 120071 6396 57122 4927 23165 4089 55746 7518 9117 11196 23243 64689 5537 10960 79902 23586 287 6710 7703 57731 3913 6687 2200 23314 11065 6230 6232 6231 6234 6235 2197 7284 140032 6227 6229 8767 2243 4249 6482 2159 2147 6441 2158 6484 2266 6487 9037 4582 6480 394263 5199 7058 4585 339366 256435 221981 727897 79875 81794 2719 80070 84061 79728 10392 11282 55741 11320 6205 6207 6209 6185 6184 23193 201595 3105 746 1603 55611 54764 55593 9630 22803 63971 26985 2782 7280 5082 79861 2785 59345 898 2783 6468 8877 10574 9097 10402 2034 387 408 5878 653509 729238 1438 7186 8737 7322 997 64326 7046 154881 7320 338 8900 84961 8924 81849 7319 7332 23014 27252 3630 25793 11275 4722 54926 4967 64410 26259 144699 79642 25898 84727 146330 92591 140460 80176 54620 55236 53339 326624 2801 4508 4509 4644 27068 9545 3418 4519 124872 9986 4758 2350 51067 124454 3313 10352 25973 57505 51601 349667 84164 94005 81847 4540 7512 4541 390243 146183 58530 8581 10020 146760 4538 251 80740 2822 55650 1048 51299 1975 54872 6975 7007 1977 10232 84992 10026 360226 6730 6726 2650 192134 55568 117248 50614 57452 64409 79623 23275 84197 9669 23265 256281 8766 22980 57171 11224 29926 197258 54516 4539 51272 57511 3376 9958 84342 22796 9609 51107 55851 9126 10735 8204 64708 50813 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 5688 2101 5689 5701 117581 9978 133522 10000 5714 4094 367 221044 10432 2908 208 5594 23314 891 207 4488 4089 5717 5718 5687 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress 23054 5688 5689 1728 5701 96764 5714 10000 1460 7296 1536 1535 1457 207 84181 2882 2539 1337 6648 571 9978 23657 1339 208 374 1350 475 55620 5753 79728 1345 7086 4199 8945 6888 6737 5717 81502 5718 3417 613227 5687 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling 53832 5781 3588 7297 163702 282618 29949 3716 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles 11168 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly 11218 96764 10073 79902 6636 6635 6637 6396 57122 4927 23165 8487 55746 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs 27327 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors 2161 2160 3818 2158 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling 3596 8809 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins 9037 9510 5199 7058 23275 339366 221981 79875 81794 80070 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 546 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis 5688 5689 5701 5714 5717 5718 5687 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG 54675 254531 50487 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter 5440 5441 51728 661 11128 2976 10621 2971 INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion 196527 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network 57761 5294 10000 5781 627 3815 5594 207 5525 5526 5527 5528 5529 2322 3630 5880 4615 3082 1956 2549 208 374 90865 8870 9965 2252 152831 27006 6801 23533 5295 23239 10818 3667 3654 79837 8660 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation 5753 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation 6129 6230 6232 6141 6231 6234 6146 6235 2197 140032 6227 6229 6156 6159 11224 6168 6169 6160 6124 6130 6170 6205 6207 6209 6128 KINESINS%REACTOME%R-HSA-983189.5 Kinesins 113220 3833 11004 23046 55582 10749 64837 81930 29127 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 7296 1728 571 23657 84181 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum 4854 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R 30849 57761 2322 5781 208 2549 9965 2252 152831 27006 5295 3479 10818 3667 5140 3481 8660 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations 2327 11046 6783 55347 373156 10249 1312 66002 574537 1800 51504 7363 9420 5447 57412 26873 64757 4128 4144 221357 389396 25830 57834 4257 4548 1558 4259 1565 54988 191 10728 10720 54579 29785 2952 1581 79094 10941 133688 10380 341392 405 2678 127 2052 27233 1585 1584 8824 54659 50512 22977 51302 9915 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling 5688 5689 5701 9978 5714 207 5717 5718 5687 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC 1460 57153 162466 10809 1457 171586 23175 56994 1120 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival 917 5567 5336 5568 2771 4627 2678 1800 6868 1432 2782 10768 2785 59345 5573 2783 5576 2781 10800 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta 7186 28512 3449 28511 8737 29110 7322 5300 3443 3441 79132 3439 55593 23586 7318 83737 9474 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints 5688 5689 25946 5701 9978 51230 5714 64326 57060 1432 4193 8945 8900 898 5717 5718 5687 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade 2782 5158 5145 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint 5688 5689 25946 5701 51230 5714 64326 57060 4193 8900 898 5717 5718 5687 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 9630 1432 2782 5028 2785 59345 2783 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 5825 23600 10998 51302 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy 51422 123 53632 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS 10675 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation 3762 3766 9568 2771 2570 2569 2782 3760 2785 59345 200959 2783 3772 2562 2557 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 7099 29110 23643 5781 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription 388585 10046 892 9978 3065 10014 1024 22938 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 545 6749 3725 5440 5441 2071 55215 404672 2966 8178 2176 2962 5436 51755 2967 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors 2900 2901 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 6230 6232 6231 6234 6235 2197 8662 8663 140032 8894 51386 3646 1968 6227 6205 6229 6207 6209 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer 8322 8323 83999 5525 22943 5526 5527 5528 5529 1487 1499 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels 3762 2782 3766 9568 3760 2785 59345 2783 3772 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 5688 5689 5701 5714 8900 898 5717 5718 5687 5753 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation 339122 23682 5872 5873 9609 64284 9230 9545 84932 57111 51552 9367 5875 5878 8766 7879 326624 81876 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade 712 5648 719 1401 1675 10584 629 4179 1361 1380 1369 730 713 735 714 2147 715 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants 5525 5526 5527 5528 5529 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 57834 1565 29785 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation 6230 6232 6231 6234 6235 2197 8662 26986 8663 140032 8894 1975 51386 3646 1968 6227 1977 6205 6229 6207 6209 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells 389692 4821 3630 10000 207 2645 208 3170 4760 3651 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 2261 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease 5295 10818 2261 2549 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis 27127 54386 545 10734 8370 8347 9126 3018 8348 10735 85236 3014 9985 7014 23353 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ 5594 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 2782 2785 59345 2783 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding 4295 10266 129521 2151 23566 56413 2865 1133 6866 5032 94233 2782 885 5028 5029 2785 84432 59345 1902 2783 6375 57121 2922 4828 10800 9038 3362 611 2846 3350 9170 222545 30817 10887 9340 623 50835 624 53829 2832 2831 2695 10268 1903 10267 338398 7476 3792 7478 2852 2696 2859 7480 5739 2587 5732 8322 5733 7474 8862 8323 8324 2918 9283 259294 6343 6348 23596 9290 9294 59350 1325 2532 353164 5368 553 6608 4852 1816 6372 1815 6364 6357 3576 6367 51554 7253 122876 2492 150 719 83756 50831 50833 50832 50834 50837 50836 50839 9568 50838 50840 5660 2847 2147 5726 54429 80835 259289 259287 259286 259285 2864 259293 259292 259290 259296 259295 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis 26035 11046 2239 9348 90161 9956 221914 2719 9672 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation 891 5520 3930 2010 9133 23592 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking 7474 7476 7478 50999 81029 9559 7480 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 917 5747 4651 4644 7454 10152 4627 695 1398 1793 644150 5594 3071 10093 10097 10163 10096 10810 998 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis 917 5295 5336 10768 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1021 1029 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 2159 2147 2158 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones 7166 1733 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases 6648 3725 1020 2801 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 27006 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis 23054 5440 5441 5914 3021 3199 7528 3018 85236 3200 3014 3213 3212 3211 7703 3725 8370 3214 2146 57472 8968 5931 9125 8347 84962 8348 5436 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade 23118 7099 7186 23643 5594 5604 1432 8767 2243 5528 1326 4208 2266 2244 7335 28512 9097 57162 28511 4615 3725 695 6280 10392 51295 8945 3654 6271 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling 3560 5295 1437 3558 1438 3716 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript 1977 6396 57122 4927 23165 79902 55746 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions 3908 3691 3685 80781 3913