S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 Glul ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a5 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Acat1 Acat2 Gcdh Echs1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5f Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk Bpnt2 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm1 Dut Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Dtymk Nme7 Nme6 Ntpcr Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Ggt5 Gstm4 Alox12 Gpx4 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Ggps1 Acat1 Hmgcr Acat2 Mvd Hmgcs2 Fdps Idi1 Mvk Pmvk L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Gstz1 Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Tomt Aldh2 Aldh3a2 Adh4 Maoa Pnmt Comt Maob N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda1 Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Amdhd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Plcb2 Ip6k2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Inpp5d Pi4kb Itpka Pi4ka Plch2 Inpp5a Plch1 Plcd1 Synj1 Inpp5b Plcd4 Itpkc Plcd3 Itpkb Itpk1 Ipmk Cdipt Pik3cg Pik3cb Ocrl Pik3cd Pip4p2 Pten Pip4p1 Inpp5k Pik3ca Pi4k2b Plcz1 Synj2 Inppl1 Pik3c2b Minpp1 Plce1 Pik3c2a Pik3c2g Fig4 Pip5kl1 Mtmr3 Ppip5k1 Ppip5k2 Pip5k1c Pip5k1b Pip5k1a L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Aldh4a1 Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Pnpla1 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis Carns1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Cad Umps Dhodh GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh Nt5c2 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Cox6a1 Ndufa10 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufa13 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs8 Coxfa4l2 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cyc1 Ndufb2 Uqcrc2 Ndufb3 Uqcrc1 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Cox6b1 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcrb Uqcr10 mt-Co2 mt-Cytb mt-Co3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 Ndufc2 mt-Co1 Sdhd Sdhc Sdhb mt-Nd1 Sdha mt-Nd2 mt-Nd3 Ndufa12 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dhdds Nus1 Srd5a3 Dolk Dhrsx PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Adss1 Pfas Ak8 Atic Ppat Paics Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Adsl Impdh1 Guk1 Gart Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk2 Nmrk1 Nmnat3 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glul Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls Pgd UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Pdss1 Ubiad1 Coq2 Coq3 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Impdh1 Nme1 Guk1 Gmps Nme7 Nme6 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme3 Nme2 Nme5 Nme4 Guk1 Nme1 Nme7 Nme6 Ak5 Dguok Dck THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Asns Gls2 Gls VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gstz1 Gsta5 Gsta3 Anpep Gstm7 Ggt5 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Mgst3 Gstt2 Mgst2 Gstt1 Mgst1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Ptgs2 Alox5 Lta4h PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Azin2 Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Pcyt2 Cept1 Etnk1 Chkb Selenoi CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis Carns1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox12 Gpx4 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Crym Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Hyal4 Hyal1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b ATP6 Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp5pf Atp6v1c1 Atpaf2 Atp6v1a Atp6v1b2 Atp6v0d1 Vps9d1 Atp5mc3 Atp5mf Atp5me Atp6v0e1 Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Fpgs Shmt2 Shmt1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Mvk Pmvk PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Bdh2 Acat1 Bdh1 Hmgcs2 Hmgcl D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Dcxr Cryl1 Akr1a1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4k2b Plcz1 Plce1 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Plcb4 Plcb3 Plcb2 Plcb1 Pi4k2a Plcg1 Plcg2 Pip4k2b Pip4k2c Pip4k2a Pi4kb Pi4ka Plch2 Plch1 Plcd1 Plcd4 Plcd3 Cdipt ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Aldh3a2 Acss2 Acss1 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Acat1 Acat2 Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Elovl7 Fads1 Fads2 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt1 B3gnt5 B3gnt2 Fut2 Fut1 A4galt B4galt4 B4galt6 B4galnt1 Gbgt1 St3gal6 St3gal4 St3gal5 St3gal2 B4galt1 B4galt2 B4galt3 B3galnt1 St6gal1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B4galt1 B4galt2 B4galt3 St6gal1 St8sia2 St8sia3 Ugcg B3gnt5 B3gnt2 B4galt4 B4galt6 St3gal6 St3gal4 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation Mtap NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt Nadk CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Chdh Aldh7a1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk1 Chkb Selenoi Gnpat Pcyt1b Pcyt1a Agps Far2 Far1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Afmid Haao Got2 Aldh8a1 Kyat3 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Dhtkd1 Aadat Kyat1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Hsd17b1 Hsd17b7 Cyp2a5 Cyp19a1 Hsd17b11 Hsd17b3 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St6gal1 B3galt4 B4galt6 Ugcg B4galnt1 St8sia1 St3gal5 St3gal2 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt1 Abo B3galt5 Fut2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Akr1b10 Cyp2e1 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat2b Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Itpk1 Ipmk GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Cbr1 Ptgs2 Tbxas1 Hpgds Hpgd Akr1c18 Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Ocrl Pip4p2 Pten Pip4p1 Inpp5k Synj2 Sacm1l Inppl1 Inpp5e Mtmr14 Inpp4a Mtmr3 Inpp4b Tpte Inpp5d Inpp5f Synj1 Inpp5b ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcs Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Alox12 Gpx4 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ptgs2 Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ggt5 Gstm4 Ephx3 Alox8 Alox12 Dpep2 Gpx4 Alox5 Cyp4f15 Dpep1 Cyp2j6 Alox15 Cyp4f3 Ltc4s Cyp2d22 Lta4h PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Ocrl Pten Inpp5k Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ppip5k2 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio1 Dio3 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd1 Txnrd3 Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Ptgs2 Alox5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Bdh2 Acat1 Bdh1 Oxct1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Dera Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Maoa Cyp1b1 Cyp2c50 Cyp1a2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Dhtkd1 Aldh8a1 Acmsd GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx1 Gpx3 Gsr Gpx7 Gpx4 Gpx2 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nampt Nmnat1 Nmnat3 Nmnat2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Mboat1 Abhd5 Mboat2 Agpat1 Agpat3 Lclat1 Agpat4 Agpat2 Cds2 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm Minpp1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Fa2h Hacl1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Fbp2 Bpgm Gpi Tpi1 Pcx Mdh1 Mdh2 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc2 G6pc3 EG433182 Pgk1 Pgam2 Pgam1 Pgk2 Fbp1 Pck1 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc2 Aldh2 Aldh3a2 Aoc3 Maoa Maob PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Elovl7 Tecr Elovl1 Hsd17b12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Hsd17b12 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggt5 Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ntpcr Ctps2 Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Pygl Pygm Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Pygb Mgam Hkdc1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Hibch Acad8 Bckdhb Hibadh Bckdha Aldh6a1 Dbt Bcat1 Dld Abat Bcat2 Echs1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Metap2 Ntan1 Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Ptgs2 Alox5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1 Got1l1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Hkdc1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 AI597479 Rtraf Tsen54 Fam98b Zbtb8os Tsen2 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tyms Tk1 Dck PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm1 Dut Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Dtymk Nme7 Nme6 Ntpcr L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Aldh18a1 Pycr2 Pycr1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta5 Gsta3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5c1a Nt5e Nt5c3a Impdh1 Pnp Gda Xdh Nt5c2 Ada L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Ahcy Mat2a Mat2b Mat1a Cbs Cth L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Mtap Mat2a Srm Mat2b Mat1a Enoph1 Adi1 Kyat1 Mri1 Apip D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Impa2 Ocrl Impa1 Inpp5k Inpp1 Synj2 Inppl1 Inpp5f Inpp5a Synj1 Inpp5b Bpnt2 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Bmpr1b Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ggt5 Gstm4 Dpep2 Alox5 Dpep1 Ltc4s Lta4h PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b6 Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp1 Xdh Rbp4 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Aldh3a2 Maoa Comt Maob MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1 Got1l1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis Gal3st1 Ugt8 St3gal5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldha Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Aldh2 Aldh3a2 Aldh1b1 Aldh3b1 Aldh3a1 Maoa Sat2 Sat1 Maob CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckmt2 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Mccc2 Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Mccc1 Auh Hmgcl Ivd GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Got1 Aga Aspg Asrgl1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Sult1a1 Aldh2 Aldh3a2 Maoa ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adss1 Ak8 Adsl Ak1 Ak3 Ak2 Ak5 Adss2 Ak7 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Haao Kmo Tdo2 Kynu Ido2 Ido1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcz1 Plce1 Plaat3 Plaat1 Plaat5 Pla2g2e Pla2g4f Plcb4 Pla2g2d Plcb3 Pla2g2f Pla2g4c Pla2g4e Pla2g4d Pld4 Plcb2 Pla2g4a Pld1 Plcb1 Plb1 Pld3 Pld2 Pla2g12a Pnpla8 Plcg1 Pla2g5 Plcg2 Pla2g3 Pla2g6 Pla2g1b Oc90 Pla2g10 Plch2 Plch1 Plcd1 Plcd4 Plcd3 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Got1 Gclc Gss Gclm COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcs Pank3 Ppcdc Pank2 Coasy Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldob Aldoc Tkfc Aldoa Sis Khk Tpi1 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Tk2 Tyms Tk1 Nme3 Nme2 Nme5 Nme4 Cmpk2 Cda Nme1 Cmpk1 Dtymk Nme7 Nme6 Dck PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chka Cept1 Chkb Pcyt1b Pcyt1a Chpt1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Afmid Haao Akr1a1 Nmnat1 Aldh8a1 Kmo Tdo2 Nmnat3 Nmnat2 Kynu Ido2 Maoa Acmsd Ido1 Maob Dhtkd1 Aldh2 Sult1a1 Aanat Tph2 Ddc Tph1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Gcdh Cyp1a2 Echs1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acox2 Scp2 Hsd17b4 Acaa1a Hadh Hsd17b10 Acsbg1 Ehhadh Slc27a2 Echs1 Acox1 Acsbg2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Ddc Aldh3a2 Akr1a1 Maob TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Vars1 Farsa Farsb Cars2 Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Iars2 Tars1 Ears2 Hars1 Pars2 Mars1 Mars2 Dars2 Yars2 Yars1 Hars2 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage Pdxk Pnpo N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda1 Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Adss1 Ak8 Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Pnp Aprt Hprt1 Ada Adsl Impdh1 Guk1 Adk Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Rrm1 Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Dctd Nme1 Dtymk Nme7 Nme6 Ntpcr UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 Ctps2 Ctps1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Dmgdh Chdh Aldh7a1 Shmt2 Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Ogdh Aco2 Sucla2 Dld Mdh1 Mdh2 Fh Sdhd Idh3a Sdhc Dlst Sdhb Idh3b Sdha Cs Idh3g Suclg1 Suclg2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Scp2 Hadh Hadha Hsd17b10 Hadhb Acaa2 Eci1 Acsbg1 Slc27a2 Echs1 Acsbg2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis B3galt1 B3gnt5 St6gal1 B3galt5 Fut2 B4galt6 Ugcg St3gal5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd2 Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Afmid Haao Aldh8a1 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Rbp1 Aldh1a2 Rdh16f2 Aldh1a1 Aldh1a3 Sdr16c5 Rbp4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide B4galt1 B4galt2 B4galt3 Abo Fut1 St8sia2 Fut9 Chst1 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Dpys Upp1 Dpyd Upp2 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio1 Dio3 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4galt1 B4galt2 B4galt3 B3gnt2 Gcnt3 Gcnt2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pfkm Pfkp Bpgm Gpi Tpi1 Hk3 Hkdc1 Gapdhs Aldob Aldoc Hk2 Eno3 Gck Eno2 Hk1 Aldoa EG433182 Pgk1 Pgam2 Pgam1 Pklr Pgk2 Pfkl Pkm HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4galt1 B4galt2 Lalba St6galnac6 St6gal1 B3gnt2 B3galt5 Fut2 B4galt4 Gcnt3 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh1 Pnp Xdh Nt5c2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 Tyrp1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Oxsm Acsf3 Mcat Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation Faah FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galnt1 B3galt5 Fut2 Fut1 A4galt B4galt6 Ugcg Gbgt1 St3gal2 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk2 Gck Hk1 Treh Hk3 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rpe65 Rbp1 Rbp2 Rbp3 Rdh5 Dhrs9 Lrat Rlbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Srd5a1 Srd5a2 Akr1c18 Cyp17a1 Hsd3b6 Hsd3b1 Hsd17b3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Impdh1 Guk1 Nme1 Nme7 Gmps Nme6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rbp1 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ptgs2 Ephx3 Alox12 Gpx4 Alox5 Alox15 Cyp2d22 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cb Pik3cd Pik3ca Pi4k2b Pik3c2b Pik3c2a Pik3c2g Fig4 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Pikfyve Pik3c3 Sacm1l Pi4k2a Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r3 Pik3r4 Pi4kb Pi4ka Cdipt Pik3cg UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpnat1 Uap1 Gnpda1 Pgm3 Hk2 Gck Gnpda2 Hk1 Gpi Hk3 Gale Hkdc1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis Hkdc1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Elovl7 Elovl6 Acot7 Acsl1 Hsd17b12 Acsbg1 Acot2 Slc27a2 Acot3 Acsbg2 Acot4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Aldh4a1 Got2 Hoga1 Prodh2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f15 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Acsbg1 Ptgr1 Slc27a2 Acsbg2 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Pgm2 Ada PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4p2 Pip4p1 Plcb2 Plcb1 Plcz1 Plce1 Plcg1 Plcg2 Mtmr14 Mtmr3 Pip4k2c Pip4k2a Plch2 Plch1 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c21 Srd5a1 Akr1c6 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Mthfd2l Aldh1l1 Mthfsl Aldh1l2 Mthfd2 Mthfr Shmt2 Shmt1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat2b Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt1 Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx1 Gpx3 Gpx7 Gpx6 Cat Gpx5 Gpx8 Sod3 Gpx2 Sod2 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5c1a Nt5e Nt5c3a Pnp Xdh Nt5c2 Ada ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Akr1b10 Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Bbox1 Aldh9a1 Shmt1 Tmlhe 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Ocrl Inpp5k Synj2 Inppl1 Ippk Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Itpk1 Ipmk LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox8 Alox12 Gpx4 Alox5 Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Daglb Cel Pnliprp2 Pnlip Lipc Pnpla2 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat3 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis Cox10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Elovl7 Fads2 Elovl2 Elovl5 Hsd17b12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4galt1 B4galt2 B4galt3 St6gal1 B3gnt2 St8sia2 Gcnt3 Gcnt2 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Aldh2 Aldh3a2 Cyp2e1 Acss2 Acss1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Aldh3a2 Acss2 Acss1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Mcee Pcca Pccb Mmut LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1 Lct Glb1l3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Fmo3 Fmo2 Fmo5 Cyp2a5 Fmo4 Cyp4x1 Cyp2u1 Cyp2s1 Ugt1a5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Pgm1 Galt Galm Galk1 Pgm2 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk2 Gck Hk1 Gpi Gfpt1 Hk3 Gfpt2 Hkdc1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Atic Adsl Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Dhtkd1 Aadat Aldh7a1 Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sephs1 Sepsecs Sars2 Sars1 Pstk Sephs2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Phyh Acsm1 Aldh3a2 Hacl1 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis Glul TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw1 Lcmt2 Tyw3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Plaat1 Gde1 Enpp2 Plaat5 Pla2g1b VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acat1 Acat2 Acsm1 Acadsb Echs1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Afmid Haao Nmnat1 Kmo Tdo2 Nmnat3 Kynu Nmnat2 Ido2 Qprt Ido1 Nadsyn1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl1 Acsl3 Acsbg1 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Plcb1 Daglb Ddhd1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Trmt112 Aqp9 Slc34a2 Aqp7 Slc2a1 Pnp Hemk2 Slc20a2 Slc20a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp2b10 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation Adh5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Ugp2 Pgm2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Ptgs2 Alox5 Lta4h ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gpi Gmppb Mpi Pmm1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss UREA CYCLE%BIOCYC%PWY-4984 urea cycle Otc Asl Cps1 Ass1 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Dmgdh Shmt2 Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Sqor Suox Tst HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas1 Alas2 Fech Hmbs Cpox Uros Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pcca Pccb Mmut L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Sds Bckdha Dbt Sdsl Dld GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Pnp Hprt1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Nos3 Nos2 Nos1 Asl Ass1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Got1 Bckdhb Bckdha Cbs Dbt Cth Dld Bhmt Mcee Pcca Bhmt2 Mtr Pccb Mmut Suox Cdo1 Ahcy Mat2a Mat2b Mat1a TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas1 Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Acat1 Hmgcr Acat2 Mvd Hmgcs2 Idi1 Mvk Pmvk TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Ppcs Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat1 Plpp4 Plpp2 Plpp3 Plpp1 Mogat1 Dgat2 Plppr4 Dgat1 Plppr2 Gpat4 Plppr3 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Agpat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis Flad1 Rfk D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Minpp1 Itpk1 Ipmk CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh Pnmt 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw1 Tyw3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Cdo1 Fmo1 Csad ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Got1 Mdh1 Mdh2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Fosb Cd44 Runx2 Kat2b Rb1 Mapk14 Tgfbr3 Prkar2a Pml Ski Map2k3 Mef2a Mef2c Brca1 Zfyve9 Rock1 E2f4 Tgfbr1 Cdkn1a E2f5 Tgfbr2 Atf2 Mapk8 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Myc Cdc27 Akt1 Sox9 Cdc23 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d1 Nup153 Trp73 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Vdr Trp53 Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Nup214 Smad3 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Tab1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Xpo4 Ctcf Hdac1 Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Eng Lef1 Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Nfyc Prkar1b Ep300 Strap Map2k6 BDNF%IOB%BDNF BDNF Ptk2b Irs2 Elk1 Gsk3b Ntrk2 Ntrk1 Mapk3 Raf1 Akt1 Mapk9 Mapk8 Shc4 Mapk7 Shc1 Irs1 Mapk1 Foxo3 Plcg1 CCR1%IOB%CCR1 CCR1 Pxn Ptk2b Mapk3 Ccr1 Zap70 Creb3 Mapk14 Src Gna14 Rela Ccl7 Ccl5 Ccl4 Ccl3 Nfkb1 Stat1 Prkcd Ptk2 Mapk1 LEPTIN%IOB%LEPTIN Leptin Stat3 Grb2 Lepr Mapk3 Mapk14 Prkcd Irs1 Irs2 Sp1 Pik3r1 Pik3r2 Pde3a Itgav Socs7 Ncoa3 Ptpn11 Slc2a4 Jak3 Jak2 Egfr Ptk2 Khdrbs1 Itgb5 Mapk1 Lep Prkce THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Map2k1 Stat5b Atxn2l Mpl Mapk3 Gab1 Jak2 Shc1 Mapk1 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Akt1 Mapk14 Prkcb Shc1 Plcg1 Gsk3b Raf1 Src Rela Stat1 Jun Ptpn11 Jak3 Jak2 Grb2 Stat5b Socs1 Mitf Socs5 Socs4 Matk Socs6 Crkl Ptpru Gys1 Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Grb7 Rasa1 Was Eif4ebp1 Cbl Mtor Epor Csf2rb2 Abl1 Fyn Grap Lyn Kitlg Pik3r1 Yes1 Crk Pik3ca Pik3r2 Stat5a Tec Fes Hras Atf2 Mapk8 Ep300 Mapk1 CCR7%IOB%CCR7 CCR7 Ptk2b Foxo1 Gsk3b Mapk3 Mtor Mapk14 Akt1 Rela Cfl1 Ccr7 Adrb2 Mapk8 Mapk1 Foxo3 Plcg1 WNT%IOB%WNT Wnt Ctnnb1 Pi4k2a Map3k7 Rac1 Ppp1ca Nfatc2 Sfrp2 Arrb2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Akt1 Dkk1 Mesd Pax2 Gsk3a Frzb Dixdc1 Chd7 Axin1 Prkcg Ror1 Ror2 Prkcb Gckr Lrp1 Arhgef4 Prkcd Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Gpc3 Dvl3 Wnt7a Wnt2 Wnt1 Gsk3b Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd5 Jup Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Fzd8 Smad1 Bcl9 Apc Jun Pin1 Tcf4 Pip5k1b Ccnd1 Cdk6 Rhoa Prkca Yes1 Lef1 Ilk Mark2 Mapk8 Sox1 Wnt5a Ctbp1 Cdh1 Setdb1 Ywhab FAS%IOB%FAS Fas Bcl2 Rac1 Fas Pkn2 Pkn1 Vim Dffa Mapk3 Cdk11b Cdc27 Akt1 Rock1 Prkcd Csnk1a1 Gsk3b Traf3 Psme3 Faf1 Eif2ak2 Arhgdib Stk24 Map3k5 Xpo5 Parp1 Traf2 Traf1 Dedd2 Plec Csnk2b Map2k1 Prkn Parg Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif3j2 Eif4b Gtf3c3 Lck Tcp1 Daxx Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Max Srf Aifm1 Uso1 Ptpn6 Uba7 Stk4 Stk3 Prkdc Rasa1 Ripk2 Fasl Numa1 Hspb1 Cflar Eif2s1 Bid Pak2 Fyn Ube4b Casp8 Lyn Casp7 Tial1 Mbd4 Tia1 Casp9 Casp4 Casp3 Casp6 Fastk Satb1 Casp2 Casp1 Ripk1 Bmx Map2k2 Wee1 Diablo Mapk1 Pdcd6 Bax ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rac1 Vim Erbb2 Clca1 Rpsa Ywhah Akt1 Ywhae Erbin Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Prkcd Pik3r3 Col17a1 Itga6 Trp73 Ntn1 Ephb2 Pak1 Shc1 Lamb2 Irs1 Lamb3 Pik3cg Sfn Irs2 Lamb1 Pik3cb Pik3cd Rtkn Bad Eif6 Lamc1 Ar Lamc2 Src Ptpn11 Egfr Ptk2 Smad2 Grb2 Plec Smad3 Rhoa Met Prkca Eif4ebp1 Mtor Abl1 Fyn Pik3r1 Yes1 Pik3ca Pik3r2 Casp3 Ywhab NGF%IOB%NGF NGF Elk1 Map2k1 Mapk3 Creb1 Dnaja3 Prkci Frs2 Mapk1 Sp1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ctnnb1 Sap18b Sufu Gas1 Kif27 Arrb2 Prkaca Ywhae Med23 Dhh Ihh Gli1 Gli3 Gli2 Shh Grk2 Ptch2 Ptch1 Dyrk1a Boc Med12 Med1 Hhip Stk36 Med6 Cdk8 Smo GM-CSF%IOB%GM-CSF GM-CSF Bcar1 Mapk3 Akt1 Mapk14 Tgfbr3 Gsk3a Map2k3 Mapk9 Shc1 Plcg1 Pxn Elk1 Gsk3b Bad Raf1 Creb1 Tgfb1 Stat1 Jak2 Stat3 Grb2 Map2k1 Ikbkb Stat5b Pdia3 Csf2ra Slc2a1 Gab1 Prdx3 Stam2 Syk Rack1 Vav1 Sptan1 Crkl Rps6ka2 Ezr Pfn1 Csf2 Ganab Stam Cct5 Dpysl2 Hck Ptprc Sh2b2 Nfkbia Bcl3 Hnrnph1 Park7 Prkca Chuk Ptpn6 Cbl Csf2rb2 Lyn Pik3r1 Yes1 Pik3r2 Stat5a Fes Mapk8 Map2k2 Mapk1 Map2k6 CCR9%IOB%CCR9 CCR9 Cd226 Foxo1 Itgb7 Ccl25 Gsk3b Itga4 Ccr9 Mapk3 Mapk14 Akt1 Ezr Mapk8 Rdx Cdh1 Madcam1 Mapk1 Msn TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Grb7 Elk1 Map2k1 Stat5b Nos3 Tie1 Mapk3 Raf1 Dok2 Tek Nck1 Mapk14 Akt1 Stat5a Fes Bmx Map2k2 Ptk2 Pak1 Shc1 Mapk1 CCR5%IOB%CCR5 CCR5 Stat3 Grb2 Ikbkb Mapk3 Akt1 Mapk14 Syk Nfkbia Chuk Ptpn6 Ptk2b Psma5 C5ar1 Afp Rela Ccl11 Ccl7 Cd4 Ccl5 Ccl12 Ccl4 Pik3r1 Ccl2 Ccr5 Stat5a Stat1 Cfl1 Mapk1 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Stat3 Stat5b Akt1 Vav1 Eif4b Crkl Map2k3 Prkcd Nfkbia Irs1 Foxo1 Irs2 Eif4ebp1 Cbl Mtor Zap70 Crk Stat5a Stat6 Stat1 Stat4 Erbb3 Pla2g4a Ifnar1 Ifnar2 Jak1 Arhgap30 Tyk2 Prkcq Map2k4 Rps6ka5 Stat2 Map2k6 TRAIL%IOB%TRAIL TRAIL H2ax Ctnnb1 Dap3 Map3k7 Bex3 Chek2 Ikbkg Tnfrsf11b Mapk3 Prkaa1 Tradd Bak1 Bcl10 Xiap Akt1 Mcl1 Mapk14 Vdac1 Tnfsf10 Apaf1 Irf5 Atm Fadd Nfkbia Tnfrsf10b Aifm1 Prkdc Cbl Cflar Bid Creb1 Src Casp8 Rela Casp7 Nfkb1 Casp3 Casp2 Casp1 Ripk1 Diablo Mapk1 Parp1 Ctsb Traf2 Bax NOTCH%IOB%NOTCH Notch Mapk3 Kat2b Skp1 App Sin3a Rbx1 Fhl1 Hivep3 Hdac2 Mfng Hey1 Numb Ccn3 Skp2 Sap30 Hes6 Tle1 Maml3 Notch4 Fbxw7 Notch1 Notch2 Notch3 Gsk3b Psen1 Pofut1 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Rela Dll1 Dll3 Dll4 Itch Maml1 Smad1 Nfkb1 Ring1 Maml2 Hes1 Furin Jag2 Jag1 Cirsr Rbpj Yy1 Jak2 Lfng Tcf3 Stat3 Smad3 Smad4 Cul1 Hdac1 Lef1 Ep300 Mapk1 M-CSF%IOB%M-CSF M-CSF Grap2 Stat3 Tfe3 Grb2 Gab3 Pstpip2 Dnm1 Stat5b Vim Csf1 Mitf Akt1 Fadd Prkcd Shc1 Ptk2b Inpp5d Cbl Casp8 Pik3r1 Stat5a Ptpn11 Ripk1 Ets2 Ptk2 Csf1r Myo18a Inppl1 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Trp53 Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Mapk7 Shc1 Plcg1 Ptk2b Irs2 Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Grb7 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Pik3ca Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Erbin Dsp Itgb4 Ywhaz Pik3r3 Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Tyk2 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Myl12b Il17rd Pard3 Mprip Prkd1 Elk4 Eps8 Gja1 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 S100a14 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Garem1 Pik3c2b mt-Co2 Antxr1 Arf4 Braf Shb Clta Pgam1 Cyld Ldha Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl1 Appl2 EG433182 Caskin2 Stx4 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Socs3 Atxn2 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Eps15 Map3k3 Magi1 Map3k2 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp4 Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Serpinb3d Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Acp1 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Sos2 Ctnnal1 Ubash3b Wbp2 Atp1a1 Sri Ephb1 Cebpb Cebpa Ephb3 Ephb4 Ahcyl1 Hnrnpa1 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Sh2b1 Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Rin1 Tln1 Vasp Arhgef7 H3c8 Hnrnpr Sdc4 Sdc3 Insr Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Pdcd6ip Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Ptprk Dcbld2 Ptprf Git1 Rps27l Vav3 Laptm4a Cdv3 Plekha6 Plekha5 Vav2 Mink1 Actn1 Prpf4b Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Wasl Cttn Mpzl1 Axl Ctnnd1 Nedd9 Huwe1 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 Peak1 Afap1l2 Ddx3x Sfpq Pdpk1 Dapp1 Iqgap1 Asap1 Anks1 Asap3 Baiap2 Lsr Epn2 Epn1 Dyrk4 Rps6ka3 Epn3 Dock4 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Egf Spry2 Spry3 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Cdc25b Nono Trim68 Ncoa1 Bag1 Gtf2h1 Psmc3ip Rbak Cdk11b Ccnd3 Runx2 Nelfcd Kat2b Pelp1 Rb1 Cdk9 Xrcc6 Cdk7 Hspa5 Xrcc5 Mdm2 Fhl2 Pias3 Pou2f1 Prmt1 Brca1 Rac3 Rnf14 Calr Nr0b2 Spdef Etv5 Efcab6 Lpxn Svil Ddc Il6st Tmf1 Arnt Hsp90b1 Zmiz2 Zmiz1 Gsk3b Rnf4 Foxa1 Magea13 Ncoa2 Ncoa6 Nsd2 Nsd1 Src Pnrc1 Pak6 Rela Stub1 Tgfb1i1 Slc25a4 Vip Rchy1 Ran Ncoa3 Egfr Stat3 Cebpa Rack1 Pten Park7 Ccne1 Ctnnb1 Ppp1ca Akt1 Sin3a Cdc25a Pxn Ar Ncor2 Sp1 Jun Tcf4 Ccnd1 Cav1 Esr1 Hspa8 Parp1 Smad3 Smad4 Prkd1 Daxx Top1 Tgif1 Hdac1 Hspb1 Brinp1 Nr2c2 Nr2c1 Nrip1 Ahr Hsp90aa1 Casp8 Uxt Casp7 Pias4 Kat5 Pik3r1 Ube2i Kat7 Gtf2f2 Gtf2f1 Casp3 Pias1 Sf1 Appl1 Ccnh Prdx1 Tle5 Casp1 Patz1 Dapk3 Flna Gsn Cdc37 Pa2g4 Ep300 Ranbp9 Senp1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Stat3 Cbl Mapk3 Gab1 Cebpa Creb1 Akt1 Lyn Stat5a Flt3 Jun Cblb Gab2 Atf2 Mapk1 CD40%IOB%CD40 CD40 Stat3 Map2k1 Ikbkb Mapk3 Myc Mapk14 Syk Akt1 Fyn Lyn Lck Pik3r1 Plcg2 Jun Fgr Nfkbia Jak3 Mapk9 Mapk8 Chuk Mapk1 TNFSF3%IOB%TNFSF3 TNFSF3 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Lta Ltb Ltbr Traf2 ID%IOB%ID ID Id2 Id1 Elk1 Id4 Smad3 Id3 Myf5 Tcf7l2 Rbl2 Rb1 Rbl1 Cdk2 Elk4 Hes1 Tcf3 Myod1 Psmd4 Atf3 Pax5 Elk3 G-CSF%IOB%G-CSF G-CSF Stat3 Grb2 Stat5b Il3ra Mapk3 Csf3r Pom121 Fth1 Pla2g1b Socs3 Akt1 Mapk14 Syk Syp Cdk2 Rel Cish Cdkn1b Csf3 Lck Hck Csnk1e Rps6ka1 Shc1 Inpp5d Cbl Prkci Lyn Stat5a Stat1 Gab2 Ptpn11 Jak1 Jak2 Tyk2 Mapk1 EPO%IOB%EPO EPO Stat3 Map2k1 Stat5b Mapk3 Gab1 Akt1 Syk Vav1 Gsk3a Crkl H2bc7 Hcls1 Sgk1 Sh2b2 Foxo4 Foxo3 Foxo1 Irs2 Bad Nos3 Raf1 Mtor Braf Epor Stat5a Jun Ptpn11 Jak2 Map2k2 Rps6ka5 Mapk1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat3 Cebpb Mapk3 Akt1 Mapk14 Crkl Spi1 Plcg2 Ifngr1 Hoxa10 Irf1 Irf2 Irf8 Mapk11 Cbl Raf1 Crk Stat5a Stat6 Stat1 Pla2g4a Jak1 Mapk8 Jak2 Prkcq Egfr Mapk1 TNFSF1%IOB%TNFSF1 TNFSF1 Ikbkg Akt1 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Tnfrsf14 Lta Ltbr TNFALPHA%IOB%TNFALPHA TNFalpha Pkn1 Map3k14 Rb1 Cdk9 Ywhah Mapk14 Ywhae Pml Map3k3 Ywhaz Map3k2 Map3k1 Mapk9 Creb1 Src Rela Nfkb1 Stat1 Traf5 Relb Tnfrsf1b Tnfrsf1a Ptpn11 Nfkb2 Egfr Ikbkb Gab1 Syk Rel Rack1 Dok1 Nfkbia Bcl3 Rpl4 Nkiras1 Nkiras2 Chuk Tbkbp1 Trib3 Map3k8 Nlrp4e Rps11 Tnf Fbl Unc5cl Tbk1 Tnfrsf11a Akt2 Dpf2 Kcnq1 Azi2 Polr1b Ppp1r13l Polr1c Polr1a Usp2 Polr1d Polr1e Stat5a Fbxw11 Txlna Tank Gtf2i Hsp90ab1 Actl6a Smarce1 Tifa Mark2 Mapk8 Cdc34 Rasa3 Nfkbiz Papola Rps6ka5 Mapk1 Glg1 Bag4 Ywhab Sec16a Map3k7 Ripk3 Cradd G3bp2 Dcaf7 Ikbkg Cops3 Mapk3 Nfkbib Nfkbie Tradd Kpna6 Kpna3 Akt1 Ccnt1 Tab3 Tab2 Skp1 Traf7 Traf4 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Hdac2 Psmd12 Ube2d3 Copb2 Map2k5 Prkcd Smarcb1 Psmd13 Alpl Rasal2 Btrc Akap8 Hdac6 Iqgap2 Psmb5 Peg3 Fbxw7 Bcl7a Ppp6c Nupr1 Fkbp5 Smarca4 Mcm5 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Psmd6 Mapkapk2 Jun Fancd2 Cops5 Psmd3 Psmd2 Traf3 Elp1 Psmd1 Cav1 Faf1 Ktn1 Spag9 Usp11 Glb1 Smarcc2 Prc1 Ddx3x Smarcc1 Crebbp Traf2 Rnf25 Traf1 Map3k11 Tnfaip3 Lrpprc Mtif2 Cul1 Tab1 Fadd Hdac1 Prkcz Hspb1 Brinp1 Cflar Nr2c2 Bid Hsp90aa1 Casp8 Casp7 Ube2i Casp3 Casp2 Ripk1 Flna Cdc37 Map2k6 GDNF%IOB%GDNF GDNF Pxn Ptk2b Bcar1 Map2k1 Ret Th Raf1 Cdc25c Gab1 Rps6ka3 Fyn Cdk1 Crk Jun Met Dok1 Nfkbia Map2k2 Ptk2 TNFSF8%IOB%TNFSF8 TNFSF8 Traf1 Nfkb1 Tnfrsf8 Relb Traf3 Nfkb2 Bcl3 Akt1 Rel Rela Mapk1 CXCR4%IOB%CXCR4 CXCR4 Bcar1 Rac1 Arrb2 Mapk3 Vav2 Map2k3 Prkcd Plcg1 Pxn Ptk2b Elk1 Gsk3b Bad Zap70 Creb1 Src Rela Nfkb1 Stat1 Ptpn11 Jak3 Jak2 Egfr Ptk2 Hspa8 Stat3 Map2k1 Ikbkb Stat5b Itk Cxcr4 Itgb2 Icam1 Gnai1 Vav1 Tff2 Lcp2 Crkl Rps6ka2 Cxcl12 Lck Gna13 Grk6 Fyb1 Plcg2 Ackr3 Cblb Esr2 Rhoa Vcam1 Limk1 Ptprc Usp14 Dok1 Nfkbia Chuk Foxo3 Ptpn6 Inpp5d Rasa1 Was Cbl Nck1 Fyn Lyn Pik3r1 Crk Sdc4 Ccr5 Pik3r2 Stat4 Cfl1 Map2k2 Mapk1 Stat2 Ywhab CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 Il4 Cabin1 Pou2f1 Ifng Fasl Cd40lg Akap5 Nfatc1 Csf2 Junb Nfatc3 Ptgs2 Nfatc2 Rcan1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Jun Fos Atf2 Il10 Sin3a Sin3b Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Tgif2 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Tfdp1 Foxo3 Foxo1 Creb1 Sap30 Col1a2 Tfe3 Dcp1a Rbl1 Itgb5 Sap18b Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Ncor1 Dlx1 Nr3c1 Myod1 Max Ep300 Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Cited1 Sp3 Runx3 Runx2 Kat2b Kat2a Cbfb Vdr Rbbp4 Rbbp7 Esr1 Hspa8 Crebbp Ski Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 E2f4 Tcf3 Cdkn1a E2f5 Smad7 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Nfkbia Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il12b Il18 Il18rap Il19 Cd3e Tnf Mpo Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Cxcl3 Jak2 Il12rb1 Pik3ca Tyk2 Nos2 Il24 Il17f Il23a Rela Il17a SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Ranbp2 Hdac4 Ube2i Mdm2 Pias1 Ran Pias2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Jun Pik3r1 Fos Mapk8 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Itgb3 Rock2 Chuk Pip5k1a Map3k14 Nfkb1 Pik3ca Rela ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Fkbp1a Mapk1 Mapk3 Smad4 Smad7 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 Eng SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Jun Pxn Irs2 Grb10 Gdnf Ptpn11 Prkaca Pik3r1 Gfra1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Mapk8 Dok5 Mapk1 Dok6 Grb2 Prkca Mapk3 Sos1 Rhoa Crk Bcar1 Hras Rac1 Creb1 Pik3ca Ret Grb7 Shank3 Shc1 Src SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Prkaca Mapk1 Mapk3 Fgf15 Col11a1 Col11a2 Cask Ccl5 Bsg Hpse Ppib Col2a1 Mmp9 Sdcbp Col3a1 Mmp7 Col1a1 Col6a1 Col5a2 Col4a3 Tgfb1 Col4a4 Col7a1 Col6a2 Hgf Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Col1a2 Fgf23 Fgfr3 Fgfr4 Mmp1a Lama5 Sdc1 Met REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Plce1 Lgals1 Lgals3 Rasgrf1 Rasgrf2 Nras Prkcb Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Sos2 Grb2 Prkca Sos1 Hras Rasa2 Rasa4 Rabgef1 Camk2b Rasal1 Nf1 Dab2ip Kras Prkcz Syngap1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Aurkb Incenp IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Stat5a Pik3r1 Il4 Cd40lg Socs1 Spi1 Stat6 Alox15 Ets1 Socs5 Myb Il10 Jak3 Aicda Jak1 Il13ra1 Il13ra2 Arg1 Bcl2l1 Fcer2a Mybl1 Dok2 Itgb3 Irf4 Lta Oprm1 Tff3 Inpp5d Akt1 Ptpn6 Thy1 Ccl17 Cbl Mtor Selp Ccl11 Gtf3a Col1a2 Pigr Mapk14 Egr2 Parp14 Il2rg Stat5b Bcl6 Fes Il4ra Hmga1 Retnlg Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Pik3ca IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Tert Lck Bcl2 E2f1 Ugcg Il2ra Ptpn11 Pik3r1 Il2 Grb2 Sos1 Myb Rac1 Jak3 Jak1 Bcl2l1 Myc Akt1 Mtor Foxo3 Il2rg Nfkb1 Pik3ca Smpd1 Il2rb Eif3a Hsp90aa1 Shc1 Sgms1 Prkcz Rela Gab2 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Il2ra Nras Stat1 Prkaca Pik3r1 Il2 Ifng Rhoa Jak3 Jak1 Il2rg Il2rb Shc1 Gab2 Irs1 Lck Bdnf Afdn Ptpn11 Kdr Angpt1 Lmo4 Gab1 Ngf Frs2 Frs3 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Grb2 Ntf4 Sos1 Ntf3 Pdgfrb Ifngr1 Hras Vegfa Pdgfb Pag1 Arhgap35 Nos3 Egf Igf1 Ntrk2 Map2k2 Ntrk1 Map2k1 Il6ra Ntrk3 Tek Igf1r Il6 Jak2 Pik3ca Kras NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Gata1 Ep300 Cdkn1b E2f1 Ar Stat3 Ncoa1 Kdr Runx2 Crebbp Myb Tcf3 Ctbp1 Spen Hdac1 Neurog3 Ncor2 Arnt Ptf1a Camk2d Ghr Hif1a Maml1 Hey2 Cd4 Maml2 Hey1 Parp1 Hes1 Twist1 Ascl1 Rb1 Jak2 Hes6 Tle1 Gaa Rbbp8 Kdm1a Rbpj Ncor1 Yy1 Notch1 Gata6 Rcan1 Myod1 Gata4 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga7 Itga8 Itgax Itga5 Itga6 Itga9 Itgam Itga4 Itga1 Itga2 Itgae Itgal Itga10 Itga11 Itgad Itgb8 Itgav Itgb6 Itgb7 Itgb1 Itga2b Itgb4 Itgb2 Itgb3 Itga3 Itgb5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Rhoa Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Ppp1r12a Fzr1 Pak1 Rock2 Ect2 Tubg1 Bub1 Cdc14b Cdc20 Ppp1cb Ppp2ca Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Wee1 Ppp2r1a Prc1 Cdk1 Bub1b Btrc Ninl Kiz Cdc25c Aurka Cenpe Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ccne1 Cstf1 Bard1 Prkdc Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad51 Rad50 Pcna Fancd2 Ewsr1 Trp53 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Ube2l3 Cdk2 Rbbp8 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Rhoa Gna12 Gnaz Gnao1 Gnai2 Gnai1 S1pr5 Gnai3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Stat5a Nras Pik3r1 Gab1 Ngf Grb2 Sos1 Hras Camk4 Ywhah Ntrk1 Ywhag Ywhae Pdpk1 Camk2a Ywhab Trpc3 Trpv1 Akt1 Agap2 Sfn Egr1 Bad Foxo3 Ccnd1 Plcg1 Creb1 Gsk3b Prkcd Ywhaz Pik3ca Kras Shc1 Src IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Jun Il18r1 Stat3 Il2ra Fos Il2 Ifng Pias2 Mapk8 Crebbp Stat4 Tgfb1 Il18 Il18rap Cd3e Cd4 Mapk9 H2-Eb1 Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Tbx21 Etv5 Irf1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Klhl9 Kif2c Ppp2r5d Smc4 Smc2 Birc5 Evi5 Ncaph Ppp1cc Npm1 Cbx5 Cdca8 Racgap1 Ncapd2 Septin1 Incenp Tacc1 Mylk Aurkb Des Nsun2 Pebp1 Rhoa Klhl13 Cul3 Vim Kif23 Kif20a Bub1 Sgo1 Aurka Psma3 Cenpa Stmn1 Ndc80 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Pik3r1 Nck1 Ptk2 Mapk1 Mapk3 Rhoa Bcar1 Rac1 Ntn1 Dock1 Elmo1 Fyn Yes1 Trio Dcc Map2k2 Map1b Wasl Map2k1 Dapk1 Pak1 Unc5b Camk2a Myo10 Unc5a Unc5c Agap2 Plcg1 Pik3ca Src S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 S1pr4 Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Gna12 Gnaz Gnao1 Gnai2 S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Map2k1 Mapk1 Pde3b Pik3cg Pik3r6 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Gata1 Cdkn1b Nras Ube2i Spi1 Ets1 Ptgs2 Myb Sin3a Pias3 Myc Adora2b Ccna1 Slc25a3 Birc3 Prtn3 Col1a2 Map3k7 Ets2 Clta Tfec Pim1 Iqgap1 Cdkn2a Rag2 Gata3 Ppid Atp2b1 Pax5 Zfpm1 Snd1 Ncor1 Maf Ptcra Kit Myod1 Smarca2 Mcm4 Ep300 Cd34 Bcl2 Lef1 Cebpb Mat2a Trim28 Cebpd Nlk Cebpa Sp1 Elane Csf1r Gstm2 Yeats4 Copa Wnt1 H2az1 Ppp3ca Kitlg Cbx4 Casp6 Anpep Mad1l1 Hspa8 Hras Crebbp Ca1 Ski Zfhx3 Cdk6 Lect2 Myf6 Tab2 Tab1 Hipk2 Ada Cdkn1a Ccnd1 Mpo Cd4 Hes1 Kras EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Pxn Nras Pik3r1 Rras Nck1 Rap1a Ptk2 Mapk1 Grb2 Mapk3 Crk Hras Rac1 Ephb1 Ephb2 Wasl Map2k1 Ephb3 Map4k4 Pak1 Ephb4 Tf Efnb1 Efnb2 Efnb3 Rap1b Synj1 Dnm1 Itsn1 Rock1 Kalrn Efna5 Pik3ca Grb7 Kras Shc1 Src FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Ezr Mapk10 Mapk11 Pik3r1 Fasl Mapk8 Syk Map3k1 Pdpk1 Chuk Akt1 Birc3 Ikbkb Mapk9 Birc2 Mapk14 Ikbkg Map2k7 Map2k6 Cltc Cflar Faim2 Pik3cb Bid Pik3ca Casp8 Smpd1 Rfc1 Casp3 Ripk1 Btk Fas Src Fadd PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Bcl2 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Tnfrsf1a Bag4 Raf1 Mapk8 Tradd Mapk1 Cradd Pdgfa Traf2 Mapk3 Ksr1 Prkra Eif2a Map2k4 Sphk2 Bax Egf Igf1 Map2k2 Map3k1 Map2k1 Map4k4 Myc Akt1 Bad Tnf Birc3 Prkcd Nfkb1 Rb1 Bid Casp8 Smpd1 Ripk1 Prkcz Rela Fadd ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Ppp2r5d Fkbp1a Ube2l3 Blk Pld1 Plcb2 Fyn Syk Klk6 Yes1 Pld2 Ptk2b Grk5 Th Tor1a Sncaip Slc6a3 Lyn Prkn Uchl1 Maob Stub1 Fgr Hck Bad Park7 Snca Prkcd Src ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Nfkbia Lck Pik3r1 Arrb2 Bcl3 Rel Ikbkb Mapk14 Nfkb1 Pik3ca Btrc Syk Rela Src RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Pkn2 Ezr Jun Pkn1 Cdkn1b Sh3gl2 Tln1 Pip5k1c Pip5k1b F2rl2 Fos Vcl Scai Mapk8 Rhoa Itgb1 Map2k4 Atf2 Pld1 Pld2 Ppp1r12a Rock2 Pip5k1a Rock1 Srf Ccn1 Slc9a1 Acta1 Mapk12 Map2k6 Pard6a Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Myl2 Limk1 Prkcz Limk2 Mrtfa SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Stat5a Stat3 Pik3r1 Rhoa Itga2b Bcar1 Blk Fyn Yes1 Itgb3 Lyn Akt1 Fgr Hck Cav1 Stat5b Shc1 Src Irs1 Lck Ins2 Prl Csf1r Ybx1 Prlr Egfr Cdh2 Dok1 Fcgr3 Csn2 Csf1 Insr Grb2 Trpv6 Txn Crk Ptpn1 Pdgfrb Csk Capn1 Pdgfb Spry2 Fer Lep Nox4 Egf Lat Lepr Socs3 Jak2 Pik3ca Tyk2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Ezr Prkaca Itga2 Mapk8 Mapk1 Sdc2 Csf2 Mapk3 Rhoa Itgb1 Hras Fgf15 Bax Cask Mmp2 Fn1 Kng2 Tnfrsf13b Sdcbp Ephb2 Cav2 Trappc4 Rack1 Epb41 Lama1 Lama3 Tgfb1 Prkcd Fgf23 Fgfr3 Fgfr4 Nf1 Casp3 Src RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Map2k1 Nras Ptpn7 Prkcb Braf Fos Map3k8 Elk1 Raf1 Mapk1 Prkca Mapk3 Hras Kras ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Jun Mapk11 Fos Pou2f1 Ifng Mapk8 Mapk1 Mapk3 Junb Cul3 Atf2 Mmp2 Arg1 Bcl2l1 Th Plau Creb1 Mapk14 Atf3 Ep300 Bcl2 Ins2 Cbfb Prkca Esr1 Brca1 Cdk4 Socs3 Hrk Ccna2 Ccnd1 Hbb-bh1 Serpinb5 Kat5 Il6 Ache Mapk9 Macroh2a1 Ddit3 Col24a1 Hes1 Jdp2 Ruvbl2 Csrp2 Rb1 Jund Gadd45a Sele Dusp5 Tgfb2 Nos2 Dusp1 Nf1 Pdgfra Il23a Dusp10 Dusp8 Ppargc1a EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna1 Efna2 Lck Efna3 Arhgef15 Crkl Ngef Epha1 Epha2 Epha3 Vav2 Epha4 Epha5 Epha6 Epha7 Cdk5 Epha8 Rhoa Crk Blk Vav3 Fyn Yes1 Lyn Fgr Pik3cg Hck Cbl Pik3r6 Plcg1 Rock1 Efna5 Src SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Gata1 Nfkbia Stat3 Prkaca Ranbp2 Hdac4 Ube2i Tnfrsf1a Ran Nr2c1 Smg5 Prmt5 Hdac3 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Sin3a Fkbp3 Sin3b Pparg Chd3 Chd4 Sirt3 Sirt2 Hdac2 Sirt1 Smurf1 Wdr77 Sirt7 Gata2 Sirt6 Hdac1 Sirt5 Sirt4 Hdac11 Hdac10 Mta2 Tfcp2 Mbd3 Mbd2 Gatad2a Sap30 Mxd1 Gatad2b Sap18b Btrc Zfpm1 Ncor1 Max Ep300 Kat2b Rbbp4 Rbbp7 Crebbp Smad7 Ncor2 Tnf Nfkb1 Yy1 Rela ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Vamp3 Exoc1 Itga7 Nme1 Itga8 Exoc2 Dnm2 Pip5k1c Itga5 Spag9 Itga6 Avpr2 Itga9 Exoc7 Bin1 Ins2 Itga4 Ctnnd1 Itga1 Mapk8ip3 Itga2 Cpe Arf6 Itga10 Itga11 Itgav Itgb1 Pld1 Pld2 Ctnnb1 Klc1 Tshr Itga3 Cdh1 Asap2 Cltc Agtr1a Slc2a4 Adrb2 Scamp2 Acap1 Rala Exoc3 Exoc4 Ctnna1 Exoc5 Exoc6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ep300 Cdkn1b Mapk10 Csnk1a1 Ran Csnk1g3 Fasl Kat2b Mapk8 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Ralb Mst1 Crebbp Sod2 Usp7 G6pc1 Rbl2 Cat Csnk1d Sgk1 Cdk2 Csnk1e Ywhah Sirt1 Ywhag Ywhae Chuk Ywhab Akt1 Foxo4 Sfn Plk1 Foxo3 Foxo1 Ikbkb Ywhaz Mapk9 Ctnnb1 Bcl6 Gadd45a Rala SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Sgpl1 Gna15 Gna14 Abcc1 Gnaq Sphk1 Gna13 S1pr1 S1pr3 S1pr4 S1pr2 Sgpp1 Gnai1 Gnai3 Sphk2 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1b Prkdc Prkaca Raf1 Bcl2l1 Ywhah Ywhag Ywhae Pdpk1 Cdkn1a Chuk Ywhab Akt1 Foxo4 Sfn Rictor Bad Mtor Map3k5 Foxo3 Akt3 Foxo1 Akt2 Gsk3b Casp9 Tbc1d4 Ywhaz Kpna1 Mapkap1 Gsk3a Mlst8 Slc2a4 Hsp90aa1 Src E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Nme1 Pip5k1c Afdn Pik3r1 Rap1a Vav2 Ctnnd1 Itgae Arf6 Itgb7 Rhoa Crk Rac1 Akt1 Rap1b Ccnd1 Ctnnb1 Cdh1 Tiam1 Nckap1 Iqgap1 Klhl20 Ap1m1 Wasf2 Pik3ca Jup Cttn Tjp1 Dlg1 Ctnna1 Rapgef1 Cyfip2 Src Abi1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Stil Dhh Hhip Ihh Lrp2 Gli2 Hhat Pik3r1 Shh Akt1 Grk2 Lrpap1 Smo Arrb2 Ptch2 Ptch1 Boc Gas1 Pthlh Cdon Pik3ca Tgfb2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk4 Plk2 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Jun Stat5a Stat3 Racgap1 Mapk8 Ncf1 Ncf2 Brk1 Arhgdia Bcar1 Noxa1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Plcb2 Actr3 Arhgap5 Pak2 Wasf1 Map3k1 Arpc3 Noxo1 Arpc2 Pak1 Cyba Abi2 Cybb Pip5k1a Arpc5 Arpc4 Map3k11 Nox1 Ctnnb1 Mapk14 Cdh1 Iqgap1 Cfl1 Map2k3 Ctnna1 Limk1 Pip5k1c Pip5k1b Crk Mapk9 Map2k7 Map2k6 Nckap1 Wasf2 Cyfip2 Abi1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Arr3 Cnga3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Rdh5 Gnb3 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef6 Spata13 Fgd1 Nme1 Arhgef9 Git1 Ngef Dnmbp Mcf2 Arhgap17 Dock10 Dock11 Vav2 Ralbp1 Farp2 Racgap1 Dock6 Bcar3 Arhgef25 Apc Arhgap1 Itsn2 Arhgdia Vav3 Itsn1 Plcg1 Arhgef7 Mcf2l HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Efna1 Ep300 Kdr Sp1 Adora2a Flt1 Epo Eif3e Ets1 Bhlhe40 Vegfa Crebbp Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Sirt1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Arnt Elk1 Twist1 Serpine1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Jun Mdm2 Pou2f1 Mapk8 Nr2c1 Hdac7 Map2k4 Sirt1 Gata2 Hdac1 Foxo1 Rel Mapk14 Hsp90aa1 Nr3c1 Src Smarca2 Ep300 Pkn1 Ar Ncoa2 Ncoa1 Cebpa Kat2b Crebbp Rack1 Hoxb13 Nr2c2 Kat7 Nr0b1 Egr1 Spdef Rxrb Rxra Gsk3b Smarce1 Kat5 Ehmt2 Rxrg Senp1 Carm1 Dnaja1 Zmiz2 Map2k6 Trim24 Appbp2 Pde9a Smarcc1 Tmprss2 Rchy1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jun Crkl Pik3r1 Fos Elk1 Plcg1 Cav1 Srf Grb2 Itgav Sos1 Crk Pik3ca Cav3 Jak1 Shb Shf Pdgfra Rapgef1 Shc1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncan Ptn Mc4r Pomc Psen1 Agrp Egfr Fgf23 Fgfr3 Fgfr4 Fgf15 Cask Cttn Fyn Ncstn Aph1b Src Sdc3 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Jun Mapk11 Cebpb Gdi1 Eif4ebp1 Pla2g4a Mitf Rab5a Elk4 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Trp53 Eif4e Mapkapk5 Mef2a Esr1 Rps6ka4 Rps6ka5 Ptgs2 Hbp1 Atf2 Mknk1 Atf6 Mef2c Creb1 Slc9a1 Mapk14 Ddit3 Nos2 Ppargc1a ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Pxn Tln1 Git1 Prkaca Itga4 Ptk2 Arf6 Itgb1 Crk Bcar1 Spp1 Rac1 Prkar1a Dock1 Prkar1b Mdk Jaml Fn1 Jam2 Ptk2b Cd81 Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Ywhaz Src Abi1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Fzd8 Dkk1 Ror2 Wnt1 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Fzd10 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd7 Fzd6 Kremen1 Fzd9 Rspo1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Fosl1 Jun Cdkn1b Fos Il2 Il4 Ifng Nfatc1 Csf2 Junb Nfatc3 Ets1 Nfatc2 Atf2 Myb Il10 Mmp9 Th Plau Gata2 Myc Tgfb1 Creb1 Ccn1 Col1a2 Ctnnb1 Acta1 Cdkn2a Cdk1 Pten Atf3 Maf Nr3c1 Ep300 Dmp1 Gja1 Edn1 Elf1 Penk Il5 Trip6 Sp1 Dmtf1 Mt2 Nts Mafg Crtc1 Bag1 Fosb Bcl2l11 Tcf7l2 Cbfb Cops5 Trp53 Fabp4 Timp1 Esr1 Agt Nppa Fosl2 H2-Q10 Egr1 Ccnd1 Hif1a Il6 Ccl12 Mmp1a Jund Dusp1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Stat5a Lyn Ptpn11 Pik3r1 Il5 Grb2 Stat5b Pim1 Jak2 Pik3ca Csf2rb2 Il5ra Cish Sdcbp INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Arhgef6 Jun Pxn Ilk Rac1 Myl12a Ilkap Ruvbl1 Rhog Ppp1r14a Ppp1r12a Ppp1r14c Ppp1r14b Elmo2 Nck2 Tns1 Git2 Parvg Akt1 Tacc3 Snai1 Lims2 Rictor Zeb1 Ccnd1 Actn1 Parvb Creb1 Gsk3b Zyx Cdc37 Parva Ctnnb1 Ckap5 Parp1 Ruvbl2 Diaph1 Iqgap1 Aurka Hsp90aa1 Arhgef7 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gja1 Pip5k1c Ptpn11 Pik3r1 Ctnnd1 Cdh2 Mapk8 Rhoa Ptpn1 Rac1 Fer Gsn Lrp5 Plcg1 Rock1 Ctnnb1 Daglb Camk2g Mapre1 Dctn1 Gap43 Kif5b Cnr1 Pik3ca Fgfr1 Jup Gria2 Cttn Dagla Axin1 Myl2 Ctnna1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Rarg Thrb Thra Bcl2 Nr1h4 Nr1h3 Nr1h2 Ncoa1 Ppard Ppara Abca1 Nr4a1 Srebf1 Vdr Pparg Tgfb1 Ncor2 Rxrb Tnf Rxra Rxrg Fam120b Rara Rarb Med1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Jun Stat5a Ctsd Hdac4 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Pdia2 Anp32a Ddx17 Ap1b1 Ddx54 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Trim59 Dscam Pgr Axin2 Ncoa7 Chuk Myc Atp5pf Hdac1 C3 Mta1 Greb1 Hsf2 Ncoa3 Xbp1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Ncor1 Ep300 Cebpb Ncoa2 Ncoa1 Lmo4 Prl Pcna Esr1 Brca1 Smad4 Ncor2 Nr0b1 Ccnd1 Med1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Stat5a Itga5 Pik3r1 Mapk8 Mapk1 Mapk3 Itgb1 Ets1 Rac1 Fyn Mmp2 Pld2 Dok2 Pak1 Akt1 Foxo1 Mapk14 Grb14 Fgf2 Angpt2 Stat5b Angpt4 Agtr1a F2 Fes Elf2 Tnip2 Plg Bmx Grb7 Shc1 Rasa1 Pxn Elf1 Ptpn11 Angpt1 Nck1 Ptk2 Grb2 Crk Nos3 Fn1 Cdkn1a Tek Elk1 Tnf Nfkb1 Pik3ca Rela DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Fosl1 Jun Il2ra Nras Prkcb Fos Prkce Il2 Ifng Fasl Mapk8 Mapk1 Nfatc1 Mapk3 Junb Nfatc3 Nfatc2 Il2rg Tnfrsf4 Il2rb Prkcq Tnfrsf9 Ifna16 B2m Gzmb Ifnar1 Eomes Ifnar2 Egr4 Cd8a Cd8b1 Tnfrsf18 Raf1 Prkca Hras H2-Q10 Map2k2 Map2k1 Stat4 Ptpn7 Braf Elk1 Egr1 Cd3e Tnf Mapk9 Cd3g Cd247 Prf1 Cd3d Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Jun Itga5 Pik3r1 Rras Mapk8 Mapk1 Itgav Rhoa Itgb1 Ets1 Bcar1 Map2k4 Rac1 Dock1 Elmo1 Fyn Yes1 Wasl Pak1 Rock2 Acta1 Itgb5 Bmx Grb7 Arhgef7 Src Rasa1 Pxn Tln1 Vcl Arhgef11 Nck1 Asap1 Rap1a Arhgef28 Mapk8ip3 Sh3gl1 Arhgap26 Ptk2 Capn2 Raf1 Klf8 Ptpn21 Grb2 Sos1 Crk Arhgap35 Map2k1 Nck2 Git2 Braf Rap1b Actn1 Ccnd1 Plcg1 Mapk9 Pik3ca Rapgef1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb2 Lama2 Lamb3 Lama5 Lamb1 Lama1 Lamc2 Lama3 Itgb4 Itga6 Lamc1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 H2ax Ube2t Blm Atm Chek1 Rad9a Top3a Wdr48 Fanci Fancm Usp1 Fancb Palb2 Rfc5 Rfc3 Rfc4 Faap100 Rfc2 Rpa1 Rpa2 Hus1 Rad17 Atrip Brip1 Cenps Fbxw11 Brca2 Xrcc3 Rad1 Faap24 Fan1 Hes1 Btrc VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Rrad Krt14 Wwp1 Rab38 Krt5 Nrg1 Cebpd Mre11a Adrm1 Il1a Axl Fbxw7 Perp Trp63 Top2a Mdm2 Vdr Hbp1 Fosl2 Atm Ada Rack1 Sfn Col5a1 Gsk3b Brca2 Yap1 Itga3 Hes1 Dlx5 Bdkrb2 Ppp2r5a Hells Cdkn2a Igfbp3 Itch Sec14l2 Stxbp4 T Fasn Tcf7l1 Notch1 Pou2f2 Ccnb2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Madd App Arhgdib Tnfrsf1a Slk Tradd Cfl2 Xiap Cradd Sptan1 Traf2 Lmna Apaf1 Gas2 Top1 Tfap2a Vim Numa1 Lmnb1 Bax Lmnb2 Pidd1 Gsn Casp7 Krt18 Casp4 Satb1 Map3k1 Casp2 Casp1 Diablo Dffa Dffb Birc3 Acta1 Limk1 Gzmb Bcl2 Ptk2 Casp6 Tnf Casp9 Birc2 Parp1 Prf1 Bid Casp8 Casp3 Ripk1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Arhgef6 Spata13 Rasgrf1 Rasgrf2 Ngef Mcf2 Arhgap17 Vav2 Ralbp1 Racgap1 Dock6 Arhgef25 Arhgap1 Sos1 Arhgdia Rac1 Dock1 Vav3 Elmo1 Trio Tiam2 Arhgef2 Dock2 Abr Eps8 Def6 Rap1gds1 Prex1 Vav1 Bcr Kalrn Arhgap9 Tiam1 Arhgef7 Abi1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Tln1 Itgam Rap1a Rhoa Mst1 Itgb2 Mmp2 Jam2 Mmp9 Plau Myh2 Thy1 Rap1b Hck Tnf Selp Rock1 Il6 Lrp1 Selplg Ccn2 Jam3 Plat Nfkb1 Ager Icam1 Plaur Mst1r Apob Plg ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pip5k1a Arf6 Kalrn Mapk1 Mapk3 Tiam1 Rhoa Plaur Rac1 Arf1 Pld1 Rab11fip3 Rab11a Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Jun Prkcb Pik3r1 Fos Pla2g4a Mapk8 Mapk1 Mapk3 Nfatc2 Map2k4 Syk Fyn Pld2 Pak2 Map3k1 Lyn Chuk Inpp5d Akt1 Cbl Vav1 Itk Plpp1 Fcer1a Shc1 Klrg1 Gab2 Hcls1 Rasa1 Cblb Wipf1 Pxn Fcer1g Lat2 Lcp2 Ptpn11 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Ptk2 Dok1 Raf1 Grb2 Sos1 Hras Fer Lat Map2k2 Map2k1 Sphk1 S1pr1 Plcg1 Ikbkb Ikbkg Map2k7 Nfkb1 Pik3ca Dusp1 Btk Rela S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Cxcr4 Gnai1 Gnai3 Mapk1 Flt1 Mapk3 Rhoa Pdgfrb Vegfa Pdgfb Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Gna13 Akt1 S1pr3 Akt3 Jak2 Src A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Itgb7 Itgb1 Rhoa Itga4 Madcam1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Rasgrf1 Crkl Stat3 Nras Pik3r1 Mapk1 Mapk3 Rhoa Rac1 Dock1 Elmo1 Shc1 Mcf2l Gab2 Rasa1 Bdnf Ptpn11 Rap1a Gab1 Ngf Frs2 Frs3 Matk Sqstm1 Faim Prkci Maged1 Ngfr Grb2 Dnaja3 Ntf4 Sos1 Shc3 Ntf3 Crk Shc2 Gipc1 Hras Rgs19 Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Ntrk2 Rhog Ntrk1 Map2k1 Ntrk3 Rap1b Dnm1 Ccnd1 Plcg1 Tiam1 Pik3ca Kras Rapgef1 Prkcz CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Nras Pik3r1 Rap1a Arf6 Rhoa Hras Rac1 Blk Fyn Syk Lat Yes1 Cyth2 Sgk1 Zap70 Cyth3 Cyth1 Dapp1 Pdpk1 Inppl1 Lyn Plekha2 Plekha1 Plcg2 Inpp5d Blnk Arap3 Fgr Adap1 Pik3cg Hck Arf5 Pik3r6 Foxo3 Plcg1 Pik3cb Pik3ca Arf1 Pten Itk Hsp90aa1 Kras Btk Src ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Stat5a Wwp1 Nrg1 Pik3r1 Prl Mdm2 Prlr Mapk1 Grb2 Mapk3 Fyn Tab2 Wwox Erbb2 Erbb4 Lrig1 Adam17 Ereg Hbegf Nrg2 Yap1 Btc Cbfa2t3 Stat5b Nrg4 Nrg3 Jak2 Dlg4 Pik3cb Grin2b Itch Pik3ca Ncor1 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Stat5a Stat3 Nras Stat1 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk1 Grb2 Csf2 Mapk3 Sos1 Hras Csf2rb2 Cish Syk Map2k2 Prkacb Map2k1 Lyn Inpp5d Ikbkb Ywhaz Ccl12 Pim1 Stat5b Jak2 Csf2ra Pik3ca Osm Irf8 Kras Shc1 Gab2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Pkn1 Mapk12 Map2k6 Mapk13 Map2k3 Ccnd1 Eef2k Map3k20 Snta1 Stmn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Vasp Efna1 Aqp5 Kifc3 Mgat3 Aqp3 Git1 Pip5k1c Nectin2 Lpp Afdn Myo6 Epha2 Vcl Stx4 Nck1 Plekha7 Ctnnd1 Camsap3 Egfr Arf6 Rhoa Egf Igf1 Igf1r Hgf Actn1 Rock1 Zyx Ctnnb1 Cdh1 Diaph1 Nckap1 Met Exoc3 Exoc4 Myl2 Ctnna1 Cyfip2 Lima1 Abi1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Mapk11 Prkaca Prkcb Pik3r1 Myof Cdh5 Ptprj Camkk2 Akap1 Mapkapk2 Mapk1 Sh2d2a Hsp90ab1 Itgav Hgs Mapk3 Ptpn2 Rhoa Vtn Fyn Pak2 Ptk2b Itgb3 Akt1 Ptpn6 Cbl Fbxw11 Cav1 Ctnnb1 Mapk14 Iqgap1 Fes Arf1 Map2k3 Hsp90aa1 Ctnna1 Src Pxn Grb10 Dnm2 Ptpn11 Kdr Vcl Nck1 Gab1 Ptk2 Raf1 Grb2 Prkca Flt1 Vegfa Nos3 Map2k2 Map2k1 Pdpk1 Nck2 Braf Plcg1 Rock1 Prkcd Map2k6 Pik3ca Shb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Fosl1 Birc5 Npm1 Eif4e Riox2 Peg10 Bmi1 Ndufaf2 Bax Bcat1 Ddx18 Trrap Shmt1 Taf12 Rcc1 Mmp9 Hspd1 Prdx3 Supt3 Cad Nme2 Myc Taf4b Mtdh Actl6a Mta1 Ldha Cdc25a Serpini1 Odc1 Taf9 Eif4g1 Gpam Rpl11 Id2 EG433182 Eif2s1 Supt7l Pfkm Pim1 Lin28b Myct1 Ccnd2 Tfrc Polr3d Hmga1 Pdcd10 Hspa4 Ireb2 Eif4a1 Hsp90aa1 Ubtf E2f3 Tk1 Tert Max Huwe1 Ep300 Nme1 Nbn Kat2a Trp53 Crebbp Smad3 Smad4 Slc2a1 Ruvbl1 Cdk4 Snai1 Kat5 Ruvbl2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp16 Lck Traf6 Mapk11 Pak3 Prkg1 Map3k3 Ccm2 Map3k12 Ralb Map2k4 Rac1 Blk Fyn Yes1 Tab1 Pak2 Pak1 Lyn Fgr Hck Mapk14 Map2k6 Rala Dusp1 Map2k3 Ripk1 Dusp10 Dusp8 Src SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Stat5a Crkl Stat3 Stat1 Pik3r1 Mitf Mapk8 Socs1 Mapk3 Lyn Akt1 Ptpn6 Cbl Foxo3 Vav1 Pten Shc1 Kit Bcl2 Grb10 Ptpn11 Stap1 Ptpro Gab1 Spred1 Spred2 Matk Epor Dok1 Grap2 Raf1 Pik3c2b Snai2 Sh2b2 Kitlg Sh2b3 Grb2 Map4k1 Sos1 Tec Epo Hras Crebbp Fer Map2k2 Map2k1 Pdpk1 Bad Gsk3b Jak2 Pik3ca GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Mapk9 Bmp4 Fgf7 Gpc3 Shh Furin Ptch1 Mapk8 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Pxn Itga9 Csf2 Itgb1 Bcar1 Vegfa Spp1 Rac1 Tnc Adam12 Adam15 Sat1 Vegfd Fn1 Vegfc Tgm2 Paox Adam2 F13a1 Adam8 Vcam1 Kcnj15 Csf2ra Nos2 Src DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Prkdc Pnkp Polm Nhej1 Dntt Aptx Dclre1c Lig4 Aplf Xrcc4 Poll Xrcc6 Xrcc5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Jun Crkl Pik3r1 Eif4ebp1 Rab5a Ptprj Mapk8 Mapk1 Eif4e Hgs Mapk3 Ptpn2 Rhoa Ets1 Bcar1 Map2k4 Rac1 Pak2 Map3k1 Wasl Pak1 Inpp5d Akt1 Cbl Mtor Ctnnb1 Cdh1 Pard6a Ctnna1 Shc1 Gab2 Src Sh3gl2 Pxn Ptpn11 F2rl2 Nck1 Rap1a Gab1 Arf6 Ptk2 Raf1 Prkci Apc Grb2 Sos1 Crk Ptpn1 Hras Map2k2 Map2k1 Pdpk1 Inppl1 Nck2 Rap1b Snai1 Hgf Egr1 Bad Plcg1 Akt2 Rptor Kpnb1 Numb Sh3kbp1 Eps15 Mlst8 Ranbp9 Rin2 Met Arhgef4 Deptor Pak4 Akt1s1 Pik3ca Muc20 Ranbp10 Rapgef1 Prkcz EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Tln1 Stat3 Pip5k1c Nras Stat1 Ptpn11 Pik3r1 Nck1 Gab1 Ptk2 Egfr Gnai1 Gnai3 Mapk1 Grb2 Mapk3 Sos1 Ptpn1 Hras Gsn Egf Wasl Pak1 Nck2 Ptpn6 Plcg1 Pik3cb Pik3ca Kras Shc1 Src PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Vasp Grk3 Snx2 Pkn1 Gng2 Snx1 Arrb1 Dnm2 Akap13 Prkcg Prkcb Pik3r1 F2rl2 Gnb1 Gnai1 Gnai3 Prkca Rhoa Arhgdia Gna12 Gnaz Nos3 Gnao1 Plcb2 Gnai2 Gna11 Gna15 Gna14 Rock2 Gnaq Gna13 Dnm1 Rock1 Zyx Prkcd F2 Pik3ca Plcb3 F2r Myl2 Arhgef1 Plcb1 Trpc6 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Dnm2 Itga5 Cxcl12 Sdc4 Fgf6 Cxcr4 Nudt16l1 Tfpi Ptk2 Prkca Rhoa Itgb1 Gipc1 Rac1 Tnc Adam12 Ccl5 Mdk Fn1 Mmp9 Tnfrsf13b Sdcbp Lama1 Lama3 Thbs1 Actn1 Prkcd Fgf2 F2 Fgfr1 Plg Fzd7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Smyd2 Cse1l Mapk8 Kat8 Fbxo11 Ppp1r13l Prmt5 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Ccng1 Chek2 Setd7 Cop1 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Daxx Akt1 Ppp2ca Rpl11 Mapk14 Nedd8 Cdkn2a Huwe1 Ep300 Trim28 Csnk1a1 Csnk1g3 Kat2b Csnk1g1 Csnk1g2 Trp53 Skp2 Crebbp Atm Usp7 Chek1 Abl1 Csnk1d Hipk2 Csnk1e Cdk2 Ccna2 Gsk3b Kat5 Prkcd Mapk9 Rchy1 Yy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Fosl1 Jun Cblb E2f1 Egr4 Il2ra Il5 Fos Batf3 Il2 Il4 Pou2f1 Ifng Fasl Cd40lg Nfatc1 Csf2 Junb Ptpn1 Nfatc3 Ptgs2 Nfatc2 Pparg Cdk4 Rnf128 Ctla4 Irf4 Ptprk Dgka Slc3a2 Egr3 Ikzf1 Foxp3 Egr1 Tnf Egr2 Gata3 Itch Tbx21 Casp3 Prkcq Maf E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Jun Gna15 Irs1 Gna14 Pak1 Gnaq Gna13 Fos S1pr2 Elk1 Cdh5 Gnai1 Mapk8 Gnai3 Mapk14 Mapk1 Mapk3 Rhoa Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Gng2 Ar Pik3r1 Fos Gnb1 Ptk2 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Rac1 Gnaz Gnao1 Plcb2 Gnai2 Map2k2 Map2k1 Plcg2 Akt1 Gnrh1 Shbg Pelp1 Plcg1 Creb1 Pik3ca Plcb3 Plcb1 Src PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Plk3 Trp53 Chek2 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Fosl1 Ep300 Jun Gja1 Sp1 Dmtf1 Nfatc1 Junb Nfatc3 Nfatc2 Itgb4 Fosl2 Nos3 Mmp2 Mmp9 Plau Lama3 Ccna2 Ccnd1 Hmox1 Txlng Il6 Usf2 Col1a2 Lif Ccl12 Dcn Thbd Mmp1a Mgp Atf4 Jund Cdkn2a Plaur ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Trim28 Mre11a Nbn Mdm2 Rad50 Fancd2 Brca1 H2ax Blm Atm Chek2 Abl1 Rad9a Top3a Cop1 Ctbp1 Ywhab Cdc25a Dclre1c Rad17 Xrcc4 Kat5 Mdc1 Terf2 Smc3 Ube2n Abraxas1 Bid Rbbp8 Uimc1 Trp53bp1 Smc1a Cdc25c HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Nfkbia Bcl2 Tnfrsf1a Bag4 Fasl Mapk8 Tradd Cradd Traf2 Casp6 Apaf1 Casp7 Casp2 Daxx Chuk Map3k14 Map3k5 Tnf Birc3 Casp9 Map2k7 Cd247 Nfkb1 Cflar Bid Casp8 Casp3 Traf1 Ripk1 Rela Fas Fadd ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Sftpa1 Myd88 Ly96 Tlr1 Chuk Vcan Saa2 Cd14 Irak4 Ticam1 Tlr6 Tirap Tlr4 S100a9 S100a8 Tlr3 Tlr2 Ikbkb Ikbkg Rhoa Irak2 Irak1 Bgn Hspd1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Stat5a Il1b Stat3 Stat1 Il2 Ifng Ebi3 Il6st Il12a Il12rb2 Il27 Il27ra Stat2 Jak1 Stat4 Tgfb1 Il12b Il18 Tnf Il6 Jak2 Il12rb1 Gata3 Tyk2 Tbx21 Il17a P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Mapk10 Psen1 Pik3r1 App Mapk8 Xiap Apaf1 Rhoa Arhgdia Rac1 Prkacb Diablo Chuk Akt1 Birc3 Plg Shc1 Irak1 Myd88 Traf6 E2f1 Bdnf Ngf Sqstm1 Prkci Bcl2l11 Maged1 Ngfr Trp53 Ntf4 Ntf3 Casp6 Rhoc Rhob Lingo1 Furin Mmp3 Omg Mag Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Ntrk1 Rtn4 Ywhae Mmp7 Ripk2 Ndn Prdm4 Sort1 Zfp369 Bad Adam17 Casp9 Ikbkb Mapk9 Birc2 Ikbkg Pik3ca Casp3 Ncstn Aph1b Prkcz CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Pip5k1b Nkd2 Ranbp3 Dvl1 Lrp6 Klhl12 Dvl2 Dvl3 Pi4k2a Cav1 Gsk3b Csnk1g1 Apc Wnt3a Ctnnb1 Gsk3a Ppp2r5a Cul3 Fzd5 Axin1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Jun Stat1 Ptpn11 Pik3r1 Fos Ctnnd1 Gab1 Frs2 Cdh2 Runx2 Mapk1 Sdc2 Grb2 Mapk3 Sos1 Fgf15 Spp1 Spry2 Ptk2b Mmp9 Plau Pdpk1 Camk2a Akt1 Cbl Plcg1 Klb Il17rd Fgf1 Fgf23 Ncam1 Fgfr3 Fgfr4 Ssh1 Fgfr2 Cdh1 Rps6ka1 Stat5b Plaur Pak4 Pik3ca Fgfr1 Cttn Shc1 Src ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Tlx2 Smad9 Fkbp1a Amhr2 Amh Bmp7 Smad5 Smad4 Bmpr2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Mak Cmtm2b Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Pawr Snurf Ube2i Appl1 Hnrnpa1 Pias1 Ncoa6 Ccnd3 Nrip1 Kdm3a Tgfb1i1 Tcf4 Vav3 Gsn Pias3 Ptk2b Tgif1 Pias4 Akt1 Pelp1 Srf Ctnnb1 Uba3 Cdkn2a Prkdc Ar Ncoa2 Xrcc6 Brca1 Xrcc5 Cdk6 Ccnd1 Carm1 Ranbp9 Hip1 Lats2 Tmprss2 Fhl2 Casp8 Kdm4c Kdm1a Znf318 Prdx1 Fkbp4 Patz1 Med1 Rps6ka3 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Vasp Pip5k1a Pik3r1 Akt1 Ctnnd1 Plcg1 Egfr Akt2 Zyx Ctnnb1 Casr Ajuba Cdh1 Rhoa Rac1 Pik3ca Jup Fyn Ctnna1 Src IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Jun Mapk11 Cebpb Stat3 Stat1 Cebpd Ptpn11 Pik3r1 Fos Mitf Lmo4 Gab1 Pias1 Il6st Grb2 Crp Timp1 Junb Sos1 Hsp90b1 Lbp Mcl1 Map2k4 Rac1 Ptpre Fgg Tnfsf11 Jak1 A2m Pias3 Bcl2l1 Il6ra Myc Socs3 Akt1 Hck Foxo1 Vav1 Il6 Prkcd Mapk14 Map2k6 Jak2 Pik3ca Tyk2 Irf1 Gab2 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Efna5 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Mdm2 Rad51 Fancd2 Topbp1 Chek1 Rad9a Mcm7 Smarcal1 Ppp2r2b Timeless Cdk2 Cep164 Cdc6 Rfc5 Tipin Rfc3 Mcm2 Rfc4 Ywhab Rfc2 Rpa1 Rpa2 Hus1 Cdc25a Ppp2ca Rad17 Plk1 Atrip Ccna2 Clspn Fbxw11 Brca2 Rad1 Ywhaz Ppp2r1a Btrc Cdc25c DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Cul1 Skp1 Dvl1 Lrp6 Dvl2 Dvl3 Csnk1a1 Gsk3b Apc Wnt3a Ctnnb1 Gsk3a Fzd5 Btrc Axin1 Csnk1d Csnk1e IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Irs2 Grb10 Crkl Ptpn11 Pik3r1 Ptk2 Raf1 Grb2 Sos1 Ptpn1 Crk Bcar1 Hras Igf1 Ywhae Pdpk1 Rack1 Nck2 Igf1r Prkd1 Akt1 Bad Prkcd Ywhaz Pik3ca Shc1 Prkcz CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Casp1 Map2k1 Pgr Vcam1 Il1b Nlrp1a Antxr2 Il18 Antxr1 Tnf Mapk1 Map2k7 Map2k6 Mapk3 Map2k4 Map2k3 Map2k2 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Gnb1 Gngt1 Slc24a1 Rdh12 Pde6a Pde6b Rgs9bp Gnat1 Cnga1 Pde6g Rho Sag Grk1 Gucy2e Rpe65 Rdh5 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccne1 Ep300 Birc5 Fos Sp1 Gas1 Aurkb Skp2 Nfatc3 Esr1 Crebbp Chek2 Mmp2 Cdk4 Cdk2 Map2k1 Myc Plk1 Ccna2 Ccnd1 Brca2 Cenpb Gsk3a Hspa1a Onecut1 Nek2 Rb1 Cdkn2a Foxm1 Cdk1 Cks1b Tgfa Lama4 Xrcc1 Etv5 Cenpf Cenpa Cdc25b Ccnb2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Grk2 Prkce Rab5a Prkca Pld1 Plcb2 Gnai2 Gna15 Gna14 Pdpk1 Lyn Akt1 Fgr Pik3cg Hck Cbl Arrb2 Dnm1 Pik3r6 Plcb3 Cxcr1 Plcb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fgb Fga F10 Tgfbi Itgax F11r Icam4 Icam2 Itgam Itgal Fcgr3 Cd40lg Itgad Itgb2 Fgg Kng2 Plau Vcam1 C3 Thy1 Ccn1 Jam3 Plat Icam1 Plaur Spon2 Proc Gp1ba INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gm14226 Gys1 Stx4 Ppp1cc Ins2 Lnpep Rhoq Trip10 Ppp1r3a Vamp2 Prkci Insr Ywhah Ywhag Ywhae Ywhab Akt1 Sfn Akt2 Gsk3b Tbc1d4 Ywhaz Slc2a4 Stxbp4 Prkcz PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Stat5a Mapk10 Stat3 Stat1 Pik3r1 Eif2ak2 Ptprj Mapk8 Mapk1 Itgav Mapk3 Ksr1 Ptpn2 Brk1 Rhoa Arhgdia Bcar1 Map2k4 Rac1 Baiap2 Arpc1b Blk Actr2 Actr3 Ppp2r2b Arpc3 Arpc2 Itgb3 Pak1 Lyn Arpc5 Arpc4 Fgr Ppp2ca Hck Srf Ppp2r1a Pten Shc1 Src Rasa1 Grb10 Ptpn11 Nck1 Rap1a Gab1 Dok1 Sla Arap1 Rab4a Usp6nl Grb2 Prkca Tagln Myocd Sos1 Dock4 Crk Ptpn1 Actn4 Csk Hras Nherf2 Nherf1 Sipa1 Ywhah Ywhag Ywhae Ywhab Braf Sfn Elk1 Plcg1 Prkcd Ywhaz Mapk9 Jund Kras Jun Nras Fos Prkce Pla2g4a Vav2 Rab5a Fyn Yes1 Pin1 Wasl Myc Eps8 Pik3cg Pik3r6 Cbl Lrp1 Stat5b Iqgap1 Lck Dnm2 Afdn Raf1 Pdgfrb Pdgfb Abl1 Pag1 Arhgap35 Map2k2 Map2k1 Nck2 Sphk1 S1pr1 Rap1b Map2k7 Nckap1 Jak2 Pik3cb Pik3ca Wasf2 Cttn Rapgef1 Cyfip2 Rps6ka3 Abi1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 F11r Pip5k1c Nectin2 Afdn Pik3r1 Rap1a Vav2 Farp2 Ptk2 Itgav Pdgfrb Crk Pdgfb Rac1 Nectin1 Nectin3 Ptprm Cldn1 Itgb3 Rap1b Ctnnb1 Cdh1 Iqgap1 Pik3ca Ctnna1 Rapgef1 Src BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Nfkbia Jun Pik3r1 Fos Vav2 Mapk8 Mapk1 Nfatc1 Mapk3 Ets1 Rac1 Syk Map3k1 Lyn Chuk Inpp5d Akt1 Ptpn6 Map3k7 Mapk14 Pten Shc1 Rasa1 Traf6 Fcgr2b Dok1 Raf1 Ppp3ca Grb2 Map4k1 Sos1 Csk Hras Pag1 Cd72 Cd22 Malt1 Card11 Map2k1 Dapp1 Cd79a Pdpk1 Cd79b Ibtk Bcl10 Plcg2 Ptprc Blnk Nfkbib Ppp3cc Ppp3cb Elk1 Cd19 Bcl2a1d Sh3bp5 Ikbkb Ikbkg Camk2g Nfkb1 Pik3ca Btk Pou2f2 Rela REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Cdkn1b Arhgef15 Ngef Akap13 Mcf2 Arhgef11 Vav2 Arhgef28 Arhgdib Arhgef25 Arap1 Rhoa Arhgdia Vav3 Arhgap35 Arhgap5 Trio Ect2 Arhgef2 Abr Arap3 Def6 Srgap1 Vav1 Arhgef3 Bcr Ophn1 Arhgap9 Arhgef17 Arhgdig Arhgef10 Arhgef12 Myo9b Arhgef18 Plekhg6 Farp1 Arhgap6 Net1 Arhgap4 Arhgef10l Dlc1 Arhgap8 Arhgef1 Mcf2l EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Snap25 Syt1 Stx1a Stxbp1 Vamp2 Unc13b Chrna1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Mark2 Adam10 Neurl1a Notch4 Notch2 Notch3 Fbxw7 Dtx1 Dll1 Il4 Dll3 Dll4 Mycbp Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Dner Lnx1 Ctbp1 Cul1 Myc Skp1 Hdac1 Cbl EG433182 Gata3 Btrc Rab11a Ncor1 Ptcra Ep300 Skp2 Furin Adam12 Cdkn1a Spen Ncor2 Dnm1 Ccnd1 Maml1 Maml2 Numb Eps15 Itch Rbbp8 Kdm1a Rbpj Yy1 Notch1 Ncstn Aph1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Stat5a Lck Bcl2 Il2ra Ptpn11 Elf1 Pik3r1 Sp1 Il2 Il4 Ccnd3 Fasl Grb2 Sos1 Jak3 Cdk6 Jak1 Bcl2l1 Lta Myc Foxp3 Ccna2 Il2rg Stat5b Prf1 Ccnd2 Pik3ca Il2rb Shc1 Gab2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Jun Mapk10 Stat3 Nrg1 Nras Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk8 Mapk1 Grb2 Mapk3 Sos1 Hras Rac1 Erbb3 Nfatc4 Nf2 Chrne Usp8 Rnf41 Map2k2 Dock7 Map2k1 Akt1 Ppp3cb Bad Erbb2 Mtor Mapk9 Nrg2 Jak2 Pik3cb Pik3ca Kras Shc1 Src Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Vasp Gng2 Arrb1 Prkcg Prkcb Gnb1 Rab5a Prkca Elmo1 Plcb2 Gnai2 Pld2 Rab7 Gna15 Cxcr2 Gna14 Pdpk1 Rac2 Lyn Dock2 Akt1 Fgr Pik3cg Ppp2ca Hck Cbl Arrb2 Dnm1 Pik3r6 Ppp2r1a Plcb3 Rab11a Plcb1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc1 Sdc4 Sdc3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Fgb Fga Tgfbi F11r Kdr Sdc4 Itgav Lamb1 Vtn Pdgfrb Itga2b Vegfa Spp1 Pdgfb Tnc Fgg Fn1 Lamc1 Plau Itgb3 Col1a1 Col4a3 Sphk1 L1cam Col4a4 Thbs1 Pecam1 Thy1 Cd47 Edil3 Col4a1 Ibsp Fbn1 Col4a5 Col4a6 Ccn1 Col1a2 Sdc1 Plaur Lama4 Tgfbr2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Jun Stat5a Mapk11 Stat3 Il2ra Nras Stat1 Prkcb Pik3r1 Fos Prkce Il2 Ifng Mapk8 Mapkapk2 Mapk1 Socs1 Mapk3 Rhoa Jak3 Jak1 Syk Fyn Ptk2b Dok2 Myc Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Il2rb Shc1 Gab2 Rasa1 Irs1 Lck Bcl2 Irs2 Ptpn11 Raf1 Grb2 Sos1 Hras Cish Map2k2 Cdk2 Map2k1 Socs3 Mapk9 Pik3ca Kras GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc1 Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Npas2 Nr1d1 Nono Cry1 Cry2 Bhlhe40 Clock Bmal1 Chek1 Per2 Per1 Wdr5 Timeless Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Stat5a Il18r1 Il1b Stat3 Il2ra Stat1 Fos Il2 Il4 Ifng Fasl Socs1 Stat6 Atf2 Sphk2 Rab7 Mtor Mapk14 Il2rg Il2rb Nfkb2 Map2k3 Ccr5 Relb Gadd45g B2m Gzma Gadd45b Gzmb Lck Hlx Eomes Ccl4 Il1r1 Cd8a Cd8b1 Il12a Il12rb2 H2-Q10 Ripk2 Stat4 Il12b Il18 Il18rap Cd3e Cd4 H2-Eb1 Cd3g Map2k6 Nfkb1 Cd247 Jak2 Cd3d Il12rb1 Tyk2 Tbx21 Nos2 Rela BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plau Vcam1 Edil3 Itga4 Madcam1 Fbn1 Ccn1 Itgb8 Itgb6 Itgav Itgb7 Itgb5 Vtn Sdc1 Plaur Tgfbr1 Fn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Vtn Bcar1 Spp1 Rac1 Vav3 Ptk2b Itgb3 Akt1 Edil3 Cbl Col1a2 Fgf2 Tgfbr2 Hsp90aa1 Src Irs1 Pxn Tln1 Angptl3 F11r Mfge8 Adgra2 Ptpn11 Kdr Vcl Pi4kb Pi4ka Pik3c2a Csf1r Ptk2 Csf1 Vegfa Col11a1 Col11a2 Igf1 Fn1 Col2a1 Col3a1 Col1a1 Col6a1 Col5a2 Igf1r Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Rock1 Col6a3 Col4a6 Sdc1 Pik3ca Casp8 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Ep300 Hdac4 Tuba1b Mef2d Acss1 Acss2 Hoxa10 Kat2b Tubb2a H1-4 Trp53 Xrcc6 Crebbp Bax Sirt3 Sirt2 Sirt1 Sirt7 Cdkn1a Foxo4 Foxo3 Foxo1 Fhl2 Myod1 Ppargc1a RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rarg Ep300 Ncoa2 Ncoa1 Prkaca Prkcg Nrip1 Kat2b Mapk8 Mapk1 Mnat1 Vdr Ccnh Prkca Mapk3 Hdac3 Cdk7 Rbp1 Crebbp Hdac1 Ncor2 Akt1 Ncoa3 Rxrb Rxra Rxrg Mapk14 Cdk1 Rara Rarb HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Rack1 Eloc Arnt Hif1a Cops5 Trp53 Rbx1 Hif3a Cdkn2a Hif1an Os9 Egln2 Naa10 Egln3 Cul2 Hsp90aa1 Vhl FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Ep300 Jun Cdkn1b Cebpb Ar Nkx3-1 Shh Fos Sp1 Ins2 Col18a1 Pou2f1 Nrip1 Vtn Esr1 Brca1 Crebbp Ap1b1 Pisd Sftpd Cyp2c55 Nfia Nfic Serpina1d Scgb1a1 Dscam Nr2f2 Gcg Foxa1 Atp5pf Foxa2 Foxa3 Ncoa3 Xbp1 Ndufv3 Prdm15 Apob NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Mapk10 Ror2 Nlk Csnk1a1 Mapk8 Rhoa Nfatc2 Rac1 Pparg Tab2 Yes1 Tab1 Camk2a Setdb1 Daam1 Chd7 Flna Dvl1 Dvl2 Arrb2 Dvl3 Wnt5a Rock1 Mapk9 Map3k7 Cthrc1 Fzd2 Fzd5 Fzd7 Fzd6 Prkcz PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gng2 Mapk11 Nras Pik3r1 Gnb1 Gnai1 Gnai3 Grb2 Sos1 Rhoa Esr1 Bcar1 Hras Gnaz Nos3 Gnao1 Plcb2 Mmp2 Igf1 Gnai2 Mmp9 Gna11 Gna15 Gna14 Rock2 Gnaq Igf1r Gna13 Akt1 Strn Pelp1 Esr2 Hbegf Pik3ca Msn Plcb3 Kras Shc1 Plcb1 Src REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Cdx4 Jun Cdx1 Ctnnbip1 Klf4 Pitx2 Bcl9 mt-Co2 Myf5 Mitf Incenp Tcf4 Hbp1 Trrap Mmp2 Mmp9 Hdac2 Axin2 Ctbp1 Cul1 Myc Skp1 Hdac1 Ccn1 Id2 Ctnnb1 Cdh1 Cdkn2a Ccnd2 Btrc Tert Dkk1 Ep300 Lef1 Vcan Ar Ncoa2 Snai2 Apc Tcf7l2 Camk4 Ywhah Ywhag Ywhae Ywhab Neurog1 Sfn Cacna1g Myog Mdfic Dvl3 Ccnd1 Igf2bp1 Cby1 Fgf4 Zcchc12 Ywhaz Tbl1xr1 Kcnip4 Tnik Adcy7 Tle4 Ruvbl2 Med12 Tle2 Tle1 Krt1 Tle5 Dkk4 Chd8 Sall4 T Smarca4 Tcf7 Tcf7l1 Tbl1x Sp5 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Stat5a Bcl2 Irs2 Crkl Stat1 Ptpn11 Pik3r1 Rap1a Vav2 Gab1 Epor Mapk8 Sh2b3 Grb2 Tec Sos1 Epo Hras Bcl2l1 Lyn Socs3 Plcg2 Inpp5d Ptpn6 Cbl Plcg1 Mapk14 Nfkb1 Stat5b Jak2 Rapgef1 Btk Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Gadd45b Traf6 Mapk11 Map3k3 Ccm2 Map3k6 Map3k4 Taok1 Taok3 Map3k10 Traf2 Txn Rac1 Atm Tab2 Tab1 Map3k1 Map3k5 Map3k7 Mapk14 Map2k6 Gadd45a Camk2b Map2k3 Gadd45g C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Max Supt3 Myc Actl6a Ppp2ca Fbxw7 Taf9 Pml Gsk3b Kat5 Kat2a Supt7l Skp2 Ruvbl2 Ppp2r5a Hbp1 Cdkn2a Trrap Axin1 Zbtb17 Pin1 Ruvbl1 Taf12 Pak2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Kdr Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Pdgfrb Ptgs2 Vegfa Pdgfb Rac1 Gnaz Gnao1 Plcb2 Gnai2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Lyn Lama1 Nrg1 Tgfb1 Tgfb3 Fgr Hck App Prnp Slit2 Gpc1 Serpinc1 Flt1 Fgf2 Vegfa Fgfr1 Smad2 Tgfbr1 Blk Tgfbr2 Fyn Yes1 Src ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Jun Prkcg Prkcb Fos Pla2g4a Prkce Mapk8 Mapk1 Ednrb Ednra Mapk3 Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Plcb2 Edn2 Edn3 Prkch Ptk2b Cysltr2 Cysltr1 Akt1 Col1a2 Slc9a1 Mapk14 Slc9a3 Prkcq Src Edn1 Gnai1 Raf1 Gnai3 Prkca Crk Hras Gna12 Gnaz Gnao1 Gnai2 Map2k2 Gna11 Col3a1 Map2k1 Gna15 Gna14 Gnaq Prkcd Mmp1a Adcy7 Jak2 Plcb3 Plcb1 Trpc6 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Flt1 Pgf Vegfb Vegfa Kdr Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Jun Mapk10 Pik3r1 F2rl2 Nck1 Mapk8 Prkci Grb2 Map2k4 Rac1 Fyn Wasl Nck2 Nphs2 Nphs1 Akt1 Cd2ap Kirrel1 Arrb2 Bad Plcg1 Mapk9 Pard6a Pik3cb Pik3ca Tjp1 Prkcz Trpc6 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Nfkbia Jun Gng2 Pik3r1 Fos Gnb1 Prkce Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Mmp2 Pld2 Ptk2b Mmp9 Lyn Prkd1 Gna13 Akt1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Src Pxn Trip6 Gab1 Egfr Ptk2 Gnai1 Gnai3 Crk Hras Nherf2 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Plcg1 Gsk3b Prkcd Hbegf Adcy7 Tiam1 Nfkb1 Pik3cb Plcb3 Casp3 Arhgef1 Rela BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga7 Itga8 Itga5 Itga6 Itga9 Itga4 Itga1 Itga2 Col18a1 Itga10 Itga11 Itgav Itgb1 Vtn Spp1 Fgg Mdk Jam2 Cd81 Plau Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Fbn1 Npnt Col1a2 Nid1 Cspg4 Plaur Lama4 Fgb Fga Tgfbi Lamb2 Lama2 Lamb3 Lamb1 Lamc2 Vegfa Col11a1 Tnc Col11a2 Fn1 Tgm2 Col2a1 Lamc1 Col3a1 F13a1 Col1a1 Col6a1 Col5a2 Lama1 Lama3 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Itga3 Lama5 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fgb Fga Itga5 Itgam Elane Egfr Itgav Vtn Pdgfrb Itgb1 Crk Bcar1 Rac1 Itgb2 Fgg Mmp3 Dock1 Fn1 Mmp9 Plau Itgb3 Tgfb1 Hgf Lrp1 Ctsg Pdgfd Itga3 Fpr1 Itgb5 Klk4 Fpr2 Gpld1 Plaur Fpr-s1 Mmp12 Serpine1 Plg Ctrc Mmp13 Vldlr Src VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Lgals1 Cdkn1b Itga6 Spi1 Hdac3 Itgb1 Ptpa Itgb4 Myc Hdac1 Cdkn2b Foxo3 Wnt5a Creb1 Col1a2 Id2 Rbl1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Max Tmem126a Dkk1 Ep300 Sfrp1 Bcl2 Tbp Csde1 Tsc2 Hmgcs2 Cebpd Nfyb Nfya Cebpa Sp1 Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Mxd4 Pdgfrb Brca1 Smad2 Smad3 Ccl5 Smad4 Zbtb17 Cdkn1a Dntt Erbb2 Ccnd1 Ddit3 Cflar Gadd45a Irf8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg1 Erbb2 Erbb4 Egfr Ereg Hbegf Nrg2 Btc Areg Nrg4 Nrg3 Tgfa Erbb3 Egf Hsp90aa1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Gata1 Gng2 Gnb1 Grk2 Ranbp2 Hdac4 Tuba1b Ube2i Ran Tubb2a Hdac3 Ankra2 Hdac5 Esr1 Bcor Hdac7 Hdac6 Rfxank Hdac9 Mef2c Camk4 Ywhae Gata2 Ywhab Ncor2 Hdac11 Hdac10 Srf Bcl6 Hsp90aa1 Nr3c1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Wwp1 Fkbp1a Pml Xiap Eif2a Smurf1 Daxx Tgfb1 Tgfb3 Ppp2ca Arrb2 Ppp1ca Cav1 Ctnnb1 Map3k7 Ccn2 Pard6a Tgfbr1 Tgfbr2 Shc1 Grb2 Sos1 Dynlrb1 Nedd4l Tgfbrap1 Smad2 Zfyve16 Smad3 Ppp2cb Smurf2 Smad4 Tab2 Strap Tab1 Dab2 Dact2 Tgfbr3 Sptbn1 Ywhae Ppp2r2a Pdpk1 Rnf111 Camk2a Ppp1r15a Zfyve9 Smad7 Bambi Yap1 Itch Axin1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Jun Crkl Lcp2 Prkcb Dbnl Map3k8 Grap2 Mapk8 Map3k7 Map4k1 Crk Map2k4 Lat Map3k1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ep300 Chp1 Bcl2 Rcan2 Fkbp1a Prkaca Prkcg Prkcb Prkce Nr4a1 Mef2d Cabin1 Csnk1a1 Ran Mapk8 Akap5 Nfatc1 Prkca Mapk3 Nfatc3 Nfatc2 Crebbp Bax Prkch Camk4 Bcl2l1 Ywhah Map3k1 Ywhag Ywhae Ywhab Fkbp8 Map3k8 Sfn Nup214 Bad Gsk3b Prkcd Kpnb1 Ywhaz Mapk9 Mapk14 Pim1 Casp3 Prkcq Prkcz Rcan1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Inpp5d Akt1 Ptpn6 Cbl Vav1 Pten Itk Prkcq Shc1 Gab2 Lck Traf6 Lcp2 Ptpn11 Nck1 Rap1a Grap2 Grb2 Prkca Trpv6 Map4k1 Sos1 Csk Hras Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Flna Dbnl Map3k8 Sla2 Orai1 Stim1 Cd3e Plcg1 Stk39 Rassf5 Was Ikbkb Cd4 Fyb1 Sh3bp2 H2-Eb1 Ikbkg Cd3g Cd247 Cd3d Cd28 Cd86 Cd80 Kras VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Prkaca Prkcb Pik3r1 Nck1 Mapk1 Prkca Flt1 Mapk3 Shc2 Vegfa Nos3 Nrp1 Nrp2 Pdpk1 Pgf Vegfb Akt1 Cd2ap Cbl Hif1a Plcg1 Cav1 Pik3ca Hsp90aa1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Grb2 Ednra Sos1 Edn1 Hras Egf Mtor Egfr Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gng2 Lgals3 Gli2 Prkaca Shh Gnb1 Smo Ptch1 Pias1 Csnk1a1 Gnai1 Csnk1g3 Csnk1g1 Gnai3 Csnk1g2 Rbbp4 Rbbp7 Crebbp Sin3a Sin3b Gnaz Gnao1 Gnai2 Csnk1d Csnk1e Hdac2 Map2k1 Foxa2 Hdac1 Akt1 Arrb2 Fbxw11 Gsk3b Sap30 Prkcd Rab23 Gli1 Gli3 Mtss1 Sap18b Ift88 Kif3a Stk36 Ift172 Btrc Sufu Spop INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Exoc1 Exoc2 Grb10 Ptpn11 Pik3r1 F2rl2 Eif4ebp1 Exoc7 Nck1 Ins2 Rhoq Trip10 Dok1 Prkci Sh2b2 Insr Grb2 Sos1 Ptpn1 Crk Hras Sgk1 Ptpra Pdpk1 Nck2 Inpp5d Akt1 Cbl Foxo3 Akt2 Cav1 Grb14 Pard6a Pik3ca Exoc3 Sorbs1 Exoc4 Rapgef1 Shc1 Prkcz Exoc5 Exoc6 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfd Pdgfrb Pdgfb Pdgfc Pdgfra EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Efna1 Pak1 Inppl1 Pik3r1 Epha2 Vav2 Cbl Ptk2 Grb2 Tiam1 Rhoa Bcar1 Rac1 Pik3ca Vav3 Arhgap35 Acp1 Shc1 Src ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Stat3 Stat1 Pik3r1 Mapk8 Mapk1 Sh2d2a Mapk3 Ksr1 Brk1 Map2k4 Rac1 Baiap2 Arpc1b Actr2 Pld1 Actr3 Pld2 Map3k1 Arpc3 Arpc2 Arpc5 Arpc4 Ppp2ca Srf Slc9a1 Smad1 Ppp2r1a Src F2rl2 Gab1 Capn2 Usp6nl Grb2 Prkca Sos1 Hras Ywhah Ywhag Ppp2r2a Ywhae Pdpk1 Ywhab Braf Sfn Elk1 Egr1 Bad Prkcd Ywhaz Mapk9 Dusp1 Kras Mapk7 Prkcz Zfp36 Map3k2 Jun Mylpf Ralgds Arf4 Ppp5c Nras Diaph3 Map2k5 Fos Dusp6 Vav2 Rab5a Rin1 Pebp1 Rps6ka4 Rps6ka5 Atf2 Bcl2l1 Wasl Akt1 Eps8 Mtor Creb1 Iqgap1 Rala Egfr Raf1 Mef2c Egf Map2k2 Map2k1 Rictor Mapkap1 Mlst8 Nckap1 Pik3cb Pik3ca Wasf2 Cyfip2 Rps6ka3 Abi1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Ywhae Ppp2r5d Clip1 Katna1 Lrpap1 Pafah1b3 Pafah1b2 Pafah1b1 Cdk5r2 Dab1 Cdk5 Dync1h1 Cdk5r1 Ndel1 Reln Dcx Rhoa Pla2g7 Iqgap1 Rac1 Abl1 Nudc Vldlr Map1b SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Ccne1 Cdkn1a Egr1 Tuba1b Itga1 Ccna2 Rock1 Mapk1 Mapk3 Rhoa Agt Itgb1 Ptp4a3 Rhoc Bcar1 Ptp4a2 Rabggta Rac1 Rabggtb Atf5 Cdk2 Src EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Ptpn13 Pik3r1 Mapk8 Itga2b Map2k4 Rac1 Blk Rgs3 Fyn Yes1 Ephb1 Ephb2 Itgb3 Ephb4 Nck2 Lyn Efnb1 Efnb2 Fgr Hck Dnm1 Map3k7 Tiam1 Pik3ca Src VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk11 Itga5 Pik3r1 Itga4 Itga1 Itga2 Mapk1 Grb2 Mapk3 Sos1 Itgb1 Crk Map2k4 Vegfd Fn1 Vegfc Flt4 Col1a1 Akt1 Creb1 Col1a2 Mapk14 Rps6ka1 Pik3ca Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Efna1 Pxn Arrb1 Git1 Epha2 Nck1 Egfr Arf6 Itga2b Gulp1 Egf Fbxo8 Cyth2 Ipcef1 Acap2 Gna11 Cyth3 Kif13b Lhcgr Gna15 Itgb3 Iqsec1 Gna14 Arap2 Gnaq Adap1 Hgf Arrb2 Tshr Agtr1a Met Adrb2 Acap1 Src P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Gata1 Mapk11 Trp63 Mdm2 Pml Jag2 Plk3 Bax Jak1 Pin1 Sirt1 Casp2 Prkacb Pfdn5 Fbxo45 Myc Tuba1a Bub1 Ccne2 Pea15 Il1rap Clca2 Ndufs2 Plk1 Hagh Foxo3 Gramd4 Aen Dcp1b Trp73 Rnf43 Mapk14 Dedd Flot2 Afp Hsf1 Wt1 Bak1 Cdk1 Bub3 Il4ra Serpine1 Ube4b Nsg1 Gdf15 Plpp1 Ep300 Bin1 Sp1 Rad51 Bcl2l11 Nedd4l Chek1 Abl1 Cdk6 Cdk2 Ada Serpina1d Ntrk1 Rack1 Cdkn1a Sfn Wwox Ccna2 Brca2 Kat5 Hey2 Yap1 Rb1 Itch Rchy1 Fasn Rela Fas CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Gng2 Mapk11 Arrb1 Nras Pik3r1 Gnb1 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Gnaz Gnao1 Gnai2 Map2k2 Map2k1 Pdpk1 Akt1 Rictor Dnm1 Mtor Ccl11 Mapk14 Cxcl9 Mapkap1 Map2k6 Mlst8 Pik3cb Pik3ca Cxcl11 Map2k3 Cxcl10 Cxcr3 Kras Pf4 Src Cxcl13 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Il3ra Cnksr1 Stat5a Srp9 Cebpb Ptpn11 Prkaca Pik3r1 Grb2 Csf2rb2 Cish Bcl2l1 Ywhag Prkacb Hdac1 Inpp5d Id1 Ywhaz Pim1 Stat5b Jak2 Pik3ca Osm Shc1 Gab2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Grk3 Gng2 Mapk11 Prkaca Prkcg Prkcb Gnb1 Prkce Grk2 Rhoa Rac1 Blk Plcb2 Syk Fyn Yes1 Prkch Lyn Vcam1 Gna13 Akt1 Fgr Hck Pik3cg Pik3r6 Arrb2 Arr3 Mapk14 Icam1 Gnb5 Rab11a Prkcq Src Lck Ptgdr Ptgir Prkg1 Tbxa2r Egfr Prkca Nherf1 Gna12 Nos3 Egf Gnai2 Tgm2 Gna11 Gna15 Gna14 Gnaq Dnm1 Rock1 Prkcd Sele Arhgef1 Prkcz A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Col17a1 Itga6 Pik3r1 Cd9 Il1a Pmp22 Egfr Lamb2 Lama2 Grb2 Lamb3 Prkca Lamb1 Itgb1 Lamc2 Hras Mst1 Itgb4 Rac1 Erbb3 Casp7 Egf Ywhah Lamc1 Ywhag Ywhae Ywhab Lama1 Lama3 Akt1 Sfn Erbb2 Rxrb Rxra Rxrg Ywhaz Cdh1 Lama5 Met Mst1r Pik3ca Lama4 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Nras Eif4ebp1 Clip1 Srebf1 Pml Mapk1 Eif4e Mapk3 Pld1 Pld2 Akt1 Mtor Fbxw11 Btrc Eif4a1 Ccne1 Irs1 Tsc2 Prr5 Rraga Ddit4 Rragb Rragc Rragd Raf1 Tsc1 Eif4b Ulk1 Ulk2 Prkca Rb1cc1 Poldip3 Pdcd4 Hras Atg13 Eef2 Sgk1 Map2k2 Cdk2 Ywhah Ywhag Map2k1 Ywhae Pdpk1 Ywhab Braf Sfn Rictor Rptor Ikbkb Ywhaz Mapkap1 Rps6ka1 Mlst8 Deptor Akt1s1 Eef2k Yy1 Kras Ppargc1a ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Chuk Nfkb1 Map3k14 Btrc Nfkb2 Relb DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Tigar Cebpz Nlrc4 E2f2 Prdm1 Prkab1 Ctsd Ppm1j Trp63 Mdm2 Col18a1 Pml Plk3 Mcl1 Spp1 Bax Pou4f1 Trrap Edn2 Pou4f2 Mmp2 Cd82 Taf9 Cav1 Hspa1a Tgfa Pten E2f3 Tsc2 Nfyb Nfya Nfyc Pcna Snai2 Ndrg1 Apc Trp53 Sfn Hgf Bcl2a1d Serpinb5 Carm1 Bdkrb2 Met Gadd45a Igfbp3 Dusp5 Rchy1 Dusp1 Jun Epha2 Perp Cse1l Apaf1 Ccng1 Pidd1 Cop1 Bcl2l1 Hdac2 Casp1 Foxa1 Tfdp1 Trp73 Lif Afp Bcl6 Bak1 Serpine1 Gdf15 Atf3 Dkk1 Ep300 Bcl2 E2f1 Vcan Sp1 Ddit4 Egfr Kat2a Vdr Casp6 Crebbp Drosha Ccnk Pcbp4 Tap1 Hic1 Ppp1r13b Msh2 Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Map4k4 Cdkn1a Rgcc Steap3 Jmy Fdxr Ddx5 Trp53bp2 Btg2 Rrm2b Ddb2 Prmt1 Bcl2l14 Rps27l Gpx1 Bcl2l2 Bnip3l Rnf144b Trp53inp1 Triap1 Irf5 Rb1 Aifm2 Dgcr8 Htt Bid Scn3b Zfp385a Arid3a Smarca4 Pms2 Cx3cl1 Pycard Fas Mlh1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkaca Prkce Lpar4 Creb1 Adcy3 Adcy7 Adcy4 Rps6ka5 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Adcy9 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Nme1 Snx1 Adam10 Dnm2 Bdnf Gdnf Slit1 Gfra1 Cbll1 Dsp Ctnnd1 Rab5a Cables1 Mep1b Igf2 Egfr Arf6 Cdh2 Robo1 Zbtb33 Hgs Ptpn1 Hras Crebbp Rac1 Abl1 Mmp3 Gna12 Fyn Egf Ntrk2 Rab7 Mmp7 Igf1r Gna13 Ptpn6 Ctnnb1 Cdh1 Tiam1 Rin2 Iqgap1 Met Jup Ret Casp3 Ctnna1 Src AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Ppp2r5d Git1 Birc5 Prkaca Mdm2 Ran Aurkaip1 Tacc1 Oaz1 Aurkb Cpeb1 Trp53 Ndel1 Ajuba Dlgap5 Tdrd7 Brca1 Fzr1 Pak1 Akt1 Tacc3 Gsk3b Tpx2 Ckap5 Gadd45a Aurka Arhgef7 Cenpa Cdc25b CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Jun Cblb Stat5a Mapk10 Traf6 Mapk11 Pik3r1 Il4 Mapk8 Cd40lg Traf2 Fcamr Traf3 Cd40 Map2k4 Tdp2 Jak3 Tnfaip3 Bcl2l1 Map3k1 Myc Map3k14 Akt1 Pik3cg Pik3r6 Birc3 Mapk9 Birc2 Mapk14 Nfkb1 Pik3cb Pik3ca Traf1 Rela VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network C3 Ncoa2 Ncoa1 Nr0b1 Ncoa3 Esr2 Smarce1 Ube2m Uba3 Nedd8 Smarcb1 Ddx54 Zfp709 Smarca4 Nr0b2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Ezr Mark2 Tsc2 Ctsd Prkaca Tsc1 Trp53 Esr1 Stk11ip Smad4 Stk26 Mark4 Crtc2 Ywhah Stradb Ywhag Smarcd3 Ywhae Strada Cab39 Etv4 Myc Ywhab Stk11 Sik3 Sik2 Sik1 Sfn Psen2 Brsk2 Brsk1 Mtor Creb1 Gsk3b Rptor Cdc37 Ywhaz Mlst8 Akt1s1 Hsp90aa1 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb2 Ephb3 Ephb4 Efnb1 Efnb2 Ephb1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map3k2 Nras Map2k5 Fos Rap1a Cdk5 Raf1 Mapkapk2 Mapk1 Cdk5r1 Mapk3 Ntf3 Rps6ka5 Hras Rit1 Mef2c Rit2 Ehd4 Map2k1 Trpv1 Braf Rap1b Elk1 Egr1 Creb1 Srf Prkcd Mapk14 Map2k6 Rps6ka1 Map2k3 Kras Mapk7 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map3k3 Stat1 Nsmaf Madd Tnfrsf1a Sqstm1 Bag4 Tradd Prkci Traf2 Txn Tnfaip3 Tab2 Smpd2 Tab1 Map3k1 Map4k4 Rack1 Chuk Nrk Map3k5 Map4k5 Tnf Map4k3 Cav1 Birc3 Adam17 Tnfrsf1b Ikbkb Cyld Birc2 Map3k7 Map4k2 Ikbkg Rffl Map2k7 Tnik Nfkb1 Casp8 Smpd1 Map2k3 Traf1 Ripk1 Prkcz Rela Fadd FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Cpt1a Bdh1 Foxf1 Cebpb Abcc8 Kcnj11 Alb Cebpd Apoa1 Hnf1a Cebpa Sp1 Cpt1b Ins2 Cpt1c Hadh Dlk1 G6pc1 Hnf4a Foxa1 Foxa2 Foxa3 Akt1 Creb1 Pklr Tat Afp Aldob Nkx2-1 Acadvl F2 Alas1 Tfrc Ttr Igfbp1 Ucp2 Slc2a2 Nf1 Pck1 Pdx1 Nr3c1 Acadm Gck CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Jun Rasgrf1 Diaph3 Pik3r1 Prkce Vav2 Mapk8 Mapk1 Mapk3 Arhgdia Bcar1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Pld1 Actr3 Yes1 Pak2 Map3k1 Arpc3 Wasl Arpc2 Pak1 Arpc5 Arpc4 Map3k11 Eps8 Cbl Mtor Ctnnb1 Mapk14 Cdh1 Pard6a Iqgap1 Cfl1 Map2k3 Myl2 Ctnna1 Limk1 Arhgef7 Limk2 Src Arhgef6 F2rl2 Exoc7 Cdc42bpa Septin2 Pax6 Raf1 Hes5 Tnk2 Apc Hras Braf Gsk3b Mapk9 Map2k7 Map2k6 Tiam1 Pak4 Pik3ca Dlg1 Prkcz CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Stat5a Gng2 Stat3 Stat1 Pik3r1 Gnb1 Cxcl12 Grk2 Hgs Rhoa Bcar1 Rac1 Blk Plcb2 Fyn Yes1 Ptk2b Mmp9 Pak1 Lyn Inpp5d Gna13 Akt1 Ptpn6 Fgr Hck Pik3cg Pik3r6 Arrb2 Mtor Foxo1 Vav1 Arr3 Stat5b Cfl1 Limk1 Src Lck Pxn Ptpn11 Cxcr4 Ptk2 Gnai1 Gnai3 Rgs1 Ubqln1 Vps4a Vps4b Crk Grk6 Stat2 Rhoc Ralb Csk Rhob Pag1 Gnaz Gnao1 Gnai2 Pdpk1 Rack1 Ptprc Rap1b Rictor Dnm1 Bad Cd3e Cd4 H2-Eb1 Ssh1 Mapkap1 Mlst8 Cd3g Cd247 Jak2 Cd3d Pik3cb Itch Pik3ca Plcb3 Plcb1 Prkcz P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Ywhag Ywhae Tcf3 Mapk11 Ywhab Tsc2 Sfn Hspb1 Creb1 Mapkapk3 Srf Raf1 Mapkapk2 Ywhaz Mapk14 Etv1 Lsp1 Cdc25b Ywhah Th PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Jun Dkk1 Ppp2r5d Adam10 Psen1 Ppard Nlk Fos Hnf1a Dtx1 Dll1 Csnk1a1 Wnt1 Apc Mapk1 Mapk3 Crebbp Nkd1 Dkk2 Frat1 Tab1 Ctbp1 Myc Hdac1 Dvl1 Lrp6 Ccnd1 Wif1 Fbxw11 Gsk3b Ctnnb1 Map3k7 Fzd1 Tle1 Kremen2 Tle5 Btrc Rbpj Axin1 Ncstn Notch1 Aph1b VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Ep300 Wwp1 Mfge8 Shh Sp1 Cables1 Perp Trp63 Mdm2 Pml Jag1 Vdr Itgb4 Hbp1 Abl1 Bax Dhrs3 Traf4 Ogg1 Spata18 Tfap2c Ada Nqo1 Smarcd3 Evpl Ssrp1 Dicer1 Cdkn1a Chuk Fdxr Clca2 Plk1 Serpinb5 Aen Prkcd Ikbkb Egr2 Flot2 Itga3 Cdkn2a Gadd45a Igfbp3 Itch Btrc Gdf15 Fas IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ep300 Cebpb Il1b Crkl Stat3 Stat1 Ptpn11 Pik3r1 Rap1a Pias1 Ifng Mapk1 Socs1 Ptpn2 Mapk3 Ifngr1 Crebbp Jak1 Map3k1 Pias4 Casp1 Map2k1 Dapk1 Camk2a Ptges2 Irf9 Smad7 Akt1 Map3k11 Rap1b Cbl Camk2d Mtor Prkcd Camk2g Jak2 Pik3ca Camk2b Irf1 Rapgef1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Pip5k1a Ap2m1 Gbf1 Uso1 Gga3 Kdelr1 Asap1 Ap2a1 Arfip2 Gosr2 Cltb Copa Arfgap1 Cd4 Clta Rac1 Arf1 Cyth2 Pld2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Jun Myd88 Traf6 Il1b Il1r1 Map3k3 Irak4 Pik3r1 Il1a Sqstm1 Mapk8 Prkci Tab2 Tab1 Casp1 Chuk Il1rap Ikbkb Ube2v1 Map3k7 Ticam2 Ikbkg Irak3 Erc1 Map2k6 Tollip Nfkb1 Il1r2 Il1rn Ube2n Pik3ca Prkcz Irak1 Rela GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Pbx1 Jun Krt14 Stat5a Smarcc2 Mapk10 Mapk11 Pomc Ppp5c Krt5 Stat1 Prkaca Fos Nr4a1 Il2 Il4 Mdm2 Pou2f1 Ifng Cdk5 Mapk8 Mapk1 Cdk5r1 Nfatc1 Spi1 Csf2 Mapk3 Fgg Bax Hdac2 Prkacb Hdac1 Akt1 Creb1 Mapk14 Afp Stat5b Icam1 Gata3 Hsp90aa1 Nr3c1 Ep300 Tbp Ncoa2 Ncoa1 Il5 Prl Csn2 Trp53 Crebbp Sgk1 Ywhah Cdkn1a Sfn Egr1 Gsk3b Il6 Mapk9 Il13 Mmp1a Nfkb1 Nr1i3 Tsg101 Smarcc1 Kmt5b Sele Fkbp5 Tbx21 Vipr1 Pou1f1 Irf1 Smarca4 Smarcd1 Fkbp4 Cga Rela Pck2 Krt17 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Cblb Stambp Sh3gl2 Amph Chmp3 Epn1 Nras Pik3r1 Zfyve28 Rab5a Ptk2 Egfr Raf1 Grb2 Hgs Sos1 Ube2d3 Hras Ube2d1 Spry2 Egf Usp8 Synj1 Cbl Dnm1 Itsn1 Lrig1 Sh3kbp1 Eps15 Tsg101 Pik3cb Pik3ca Kras Arhgef7 Shc1 Src E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdkn1b E2f2 Uxt Ces1d Tfdp2 Cdkn2c Cbx5 Tyms Mybl2 Sult2a1 Ccnd3 Ranbp1 Mcm3 Ces2h Ces4a Prmt5 Pola1 Apaf1 Dhfr Rybp Orc1 Mcl1 Ces3b Hbp1 Rrm1 Ces5a Rrm2 E2f6 Trrap Casp7 E2f7 Wasf1 Sirt1 Cdc6 Plau Myc Hdac1 Ccne2 Cdc25a Tfdp1 Trp73 Tfe3 Rbl1 Cdkn2a Cdk1 Serpine1 Xrcc1 E2f3 Tk1 Ccne1 Smarca2 Ep300 E2f1 Trim28 Cebpa Sp1 Kat2b Kat2a Rbbp4 Topbp1 Brca1 Crebbp Atm Rbl2 Hic1 Cdk2 E2f4 Cdkn1a E2f5 Ccna2 Rb1 Rbbp8 Yy1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Ripk2 Traf6 Chuk Bcl10 Tnf Tnfrsf1a Ran Ikbkb Cyld Birc2 Ikbkg Erc1 Prkca Nfkb1 Ube2d3 Atm Btrc Tnfaip3 Nod2 Rela Malt1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Akt1 Ptpn6 Cbl Vav1 Prkcq Shc1 B2m Lck Traf6 Lcp2 Cd8a Cd8b1 Rap1a Grap2 Grb2 Prkca Trpv6 Sos1 Csk Hras H2-Q10 Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Map3k8 Orai1 Stim1 Cd3e Plcg1 Rassf5 Ikbkb Ikbkg Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Kras REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Jun Cdkn1b Ube3a Fos Il2 Ifng Mapk1 Smg5 Mapk3 Sin3a Sin3b Terf1 Smg6 Hdac2 Tinf2 Parp2 Tnks Dkc1 Pot1 Myc Pif1 Hdac1 Wrn Tgfb1 Acd Akt1 Znfx1 Terf2ip Hnrnpc Pinx1 Mtor Sap30 Mxd1 Sap18b Terf2 Wt1 Hsp90aa1 Tert Max Ifnar2 E2f1 Mre11a Nbn Sp1 Sp3 Egfr Rad50 Rbbp4 Rbbp7 Xrcc6 Esr1 Xrcc5 Blm Atm Abl1 Rad9a Smad3 Egf Ywhae Nr2f2 Hus1 Ccnd1 Rad1 Nfkb1 Irf1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Jun Cdkn1b Mapk11 E2f2 Mitf Mdm2 Ccnd3 Spi1 Csf2 Hdac3 Atf2 Smarcb1 Pparg Sirt1 Ctbp1 Hdac1 Ppp2ca Tfdp1 Suv39h1 Brd2 Pax3 Aatf Rbp2 Atf7 Mapk14 Ckm Dnmt1 Taf1 Cdkn2a Ccnd2 Ubtf E2f3 Myod1 Ccne1 Ep300 Tbp Cebpb E2f1 Elf1 Cebpd Cebpa Gsc Runx2 Raf1 Cbx4 Rbbp4 Skp2 Crebbp Abl1 Cdk6 Mef2c Sftpd Cdk4 Cdk2 E2f4 Cdkn1a Ccna2 Ccnd1 Mapk9 Met Rb1 Tgfb2 Smarca4 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Pias4 Ctdsp1 Nup214 Ube2i Kpnb1 Mapk1 Mapk3 Ppm1a Nup153 Ctdspl Smad2 Tgfbrap1 Smad3 Smad4 Map3k1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Jun Fos Cxcl12 Npm1 Ets1 Hdac7 Mcl1 Itgb2 Hnf4a Gata2 Tff3 Akt1 Ldha Hmox1 Creb1 Id2 EG433182 Plin2 Tfrc Adm Serpine1 Cp Igfbp1 Pfkfb3 Eng Nt5e Car9 Pgm1 Fech Pkm Gck Tert Aldoa Ep300 Abcb1a Pfkl Rora Hk2 Edn1 Ncoa2 Hk1 Ncoa1 Bhlhe41 Sp1 Cxcr4 Ndrg1 Cops5 Epo Bhlhe40 Vegfa Crebbp Furin Egln3 Smad3 Lep Cited2 Smad4 Pgk1 Slc2a1 Abcg2 Tf Arnt Hif1a Nos2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Crkl Pik3r1 Grin2a Mapk8ip1 Rap1a Lrpap1 Pafah1b1 Dab1 Cdk5 Mapk8 Cdk5r1 Reln Itgb1 Fyn Map1b Nck2 Arhgef2 Akt1 Map3k11 Cbl Gsk3b Map2k7 Itga3 Grin2b Pik3ca Vldlr Rapgef1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Chuk Pik3r1 Dap3 Tnfsf10 Ikbkb Mapk8 Tradd Mapk1 Ikbkg Traf2 Mapk3 Cflar Map2k4 Pik3cb Pik3ca Casp8 Smpd1 Ripk1 Map3k1 Fadd RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk14 Gng2 Mapk11 Gnb1 Crh Mapk8 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Stat5a Stat3 Stat1 Pik3r1 Kdr Eif2ak2 Ins2 Csf1r Itga1 Gab1 Lman1 Pias1 Egfr Rab4a Csf1 Insr Grb2 Stat6 Ptpn2 Sos1 Ptpn1 Pdgfrb Itgb1 Eif2a Vegfa Crebbp Pdgfb Jak3 Jak1 Egf Hgf Kpnb1 Stat5b Met Pik3cb Pik3ca Shc1 Src BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Ctdsp1 Grem1 Ahsg Sostdc1 Mapk1 Rgmb Xiap Rgma Hjv Chrd Cer1 Bmp4 Fst Nog Bmpr1a Ski Bmp6 Zfyve16 Bmp2 Smad6 Smad4 Smurf2 Tab2 Tab1 Smurf1 Ppp1r15a Smad7 Bambi Nup214 Ppp1ca Gsk3b Bmpr2 Map3k7 Smad1 Smad9 Ppm1a Bmp7 Ctdspl Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna15 Gna14 Gng2 Rock2 Gnaq Gna13 F2rl2 Gnb1 Rock1 Rhoa F2 Plcb2 F2rl3 Myl2 Gna11 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga Appl1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Med23 Med12 Med1 Dhh Hhip Ihh Stk36 Prkaca Ctnnb1 Gli1 Med6 Gli2 Cdk8 Ywhae Grk2 Ptch2 Sap18b Ptch1 Dyrk1a Sufu Boc Arrb2 Gas1 Kif27 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Creb1 Ar Hdac1 Hspb1 Akt1 Pik3r1 Ptk2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Runx2 Rb1 Kat2b Tgfbr3 Prkar2a Trim33 Pml Ski Map2k3 Samd3 Mef2a Mef2c Brca1 Zfyve9 E2f4 Cdkn1a Tgfbr2 Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Ube2i Myc Sox9 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d1 Nup153 Trp73 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Pik3ca Ccnd1 Vdr Trp53 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Nup214 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Tab1 Junb Daxx Smad6 Hnf4a Ing2 Xpo1 Xpo4 Pdpk1 Ctcf Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Eng Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Prkar1b Nfyc Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Fosb Runx3 Cd44 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Pag1 Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Shb Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Pgam1 Jak3 Ptprh Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Card11 Bdh1 Ldha Ldhb Tuba4a Prpf4b Icos Zdhhc17 Golga5 Ctla4 Was Cd3g Actr10 Cd3e Cd3d Dusp3 Def6 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Elp3 Mpzl1 Map2k1 Rapgef1 Hnrnph3 Nedd9 Stat1 Dbnl Mapk7 Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Erbin Cd86 Sdcbp Cd84 Sh2d2a Cd82 Cd80 Snrnp70 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Fcrl5 Stk39 Pkp4 Flnb Anxa2 Raf1 Inpp5d Shc1 Pi4ka Stk4 Acly Ripk2 Elmo1 Abl1 Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Txnrd1 Pecam1 Nfatc1 Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Ddx49 Pkm Lck Evl Sos2 Lcp2 Sos1 Lpxn Ywhaz Eif3m Ubash3b Atp1a1 Src Atp1a3 Ptpn6 Trim25 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh2b3 Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Runx2 Esr1 Akt1 Src Ptk2 Jak3 Mapk1 Shc1 Plcg1 Plcg2 Khdrbs1 Chuk Crp Erbb2 Irs1 Irs4 Eif4ebp1 Pde3a Socs7 Gsk3b Prkaa1 Prkaa2 Gnaq Slc2a4 Fyn Jak1 Nos3 Cfl2 Sh2b1 Egfr Eif4e Stat1 Gsk3a Cdk5 Itgb5 Mapk8 Lep Nfkbia Limk1 Prkce Rps6ka2 Acacb Ncoa1 Igf1r Grb2 Ikbkb KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Matk Socs6 Ptpru Gys1 Akt1 Jak2 Sh3kbp1 Pik3r1 Mad2l1 Atf2 Rela Fgr Hck Prkcb Rps6ka1 Mapk1 Kit Tnfrsf10b Prkca Il7r Spred1 Ezr Raf1 Spred2 Inpp5d Grb7 Ep300 Mtor Crkl Epor Csf2rb2 Mapk12 Yes1 Cblb Abl1 Kitlg Rdx Msn Wipf1 Stat5a Stat5b Fes Cdk2 Hras Rasa1 Grap Jun Pik3ca Sos1 Cltc Src Jak3 Ptpn11 Mapk14 Tec Was Eif4ebp1 Gsk3b Crk Fyn Stat1 Mapk8 Socs1 Mitf Socs5 Socs4 BCR%NETPATH%BCR BCR Rb1 Hck Prkcb Rps6ka1 Prkd1 Crkl Plcg1 Prkcd Cdk2 Cd72 Stap1 Elk1 Sla2 Rasa1 Chst15 Malt1 Prkcq Gtf2i Tcl1 Rasgrp3 Btk Bcl10 Pip4k2b Pip4k2c Pip4k2a Cd79a Lyn Cd79b Pik3cg Cdk7 Bcl6 Btla Hnrnpk Itpr2 Bank1 Nfatc3 Cd22 Plekha2 Plekha1 Grb2 Hcls1 Lat2 Ikbkb Blnk Itk Ptpn18 Ccl4 Casp7 Mapkapk2 Casp9 Sh2b2 Fcgr2b Bax Stat3 Pip5k1c Pip5k1b Pip5k1a Vav1 Card11 Rapgef1 Ctnnb1 Nedd9 Stat1 Creb1 Akt1 Ptk2 Atf2 Rela Dok1 Mapk1 Shc1 Itpr1 Zap70 Nck1 Nfatc2 Jun Lck Sos2 Sos1 Map4k1 Ptpn6 Junb Mapk14 Pdpk1 Sh3bp2 Tec Foxo3 Chuk Fos Eif4ebp1 Gsk3b Crk Fyn Pik3r2 Gsk3a Bcar1 Fosb TNFALPHA%NETPATH%TNFALPHA TNFalpha Prkca Ep300 Stat5a Gtf2i Casp7 Mapkapk2 Bax Nkiras1 Rpl4 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tbk1 Tnfrsf11a Dpf2 Kcnq1 Tax1bp1 Polr1b Polr1c Txnip Polr1a Polr1d Polr1e Actl6a Smarce1 Tifa Cdc37 Cdc34 Rffl Rasa3 Akt2 Nfkbiz Txn Glg1 Sec16a Cradd Dcaf7 Nfkbie Diablo Rel Faf1 Ikbkg Tnfrsf8 Ikbke Mark2 Tnfrsf1b Rfk Akap8 Psmb5 Ywhae Gab1 Bcl2l1 Rack1 Fkbp5 Fbxw7 Fadd Smpd3 Psmc2 Psmc1 Psmc3 Map2k5 Creb1 Itch Bid Hdac1 Commd1 Hspb1 Akt1 Trpc4ap Psmd7 Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Elp1 Psmd1 Mapk1 Ktn1 Pkn1 Map3k11 Lrpprc Mapk9 Brinp1 Mapk3 Nr2c2 Nlrp4e Ube2i Tnf Map3k5 Skp1 Hsp90aa1 Pdk1 Fbl Ppp1r12a Unc5cl Ppp1r13l Usp2 Xiap Fbxw11 Txlna Ube2d3 Tank Relb Map3k3 Map3k2 Btrc Rxra Flna Papola Bag4 Ripk3 G3bp2 Cops3 Kpna6 Kpna3 Cdk9 Zbtb17 Cyba Ccnt1 Trap1 Bcl3 Tab3 Tab2 Traf7 Mcm7 Traf4 Pfdn2 Traf6 Traf5 Birc3 Jun Birc2 Ywhah Ywhag Psmd12 Copb2 Hdac2 Cav1 Smarcb1 Ywhab Psmd13 Alpl Rasal2 Rnf11 Hdac6 Iqgap2 Peg3 Bcl7a Ppp6c Nupr1 Rps6ka5 Mcm5 Smarca4 Cul1 Tnip2 Polr2h Tab1 Pdcd2 Junb Nsmaf Zfand5 Cflar Casp3 Romo1 Casp2 Trim32 Spag9 Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Foxo1 Mtif2 Map2k6 Rb1 Pml Nfkbia Crebbp Grb2 Nfkb1 Pak1 Stat1 Mapk8 Map3k8 Hsp90ab1 Dok1 Ddx3x Sos2 Sos1 Ywhaz Src Ptpn11 Mapk14 Irs1 Egfr ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Lamc1 Ar Lamc2 Vim Akt1 Pik3r1 Ptk2 Mapk1 Prkca Mapk3 Shc1 Mtor Yes1 Abl1 Prkcd Trp73 Pik3cg Jun Ywhah Pik3ca Grb2 Ywhab Ywhaz Src Ptpn11 Mapk14 Casp3 Clca1 Erbb2 Rpsa Irs1 Irs2 Fos Rhoa Pak1 Rac1 Eif4ebp1 Plec Dsp Lama5 Cd151 Itgb4 Lama2 Lama3 Fyn Mst1r Pik3r2 Met Mylk3 Pik3r3 Egfr Col17a1 Eif4e Itga6 Ntn1 Ephb2 Ywhae Lamb2 Gab1 Lamb3 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Erbin Smad2 Smad3 Eif6 WNT%NETPATH%WNT Wnt Map3k7 Sox1 Akt1 Ctbp1 Wnt5a Cdh1 Setdb1 Pi4k2a Prkcb Ppp1ca Sfrp2 Ppp2ca Sfrp1 Prkca Daam1 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Yes1 Lrp1 Arhgef4 Csnk1a1 Nlk Prkcd Lrp5 Gpc3 Dvl3 Wnt2 Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Smad1 Bcl9 Pin1 Tcf4 Nfatc2 Jun Ccnd1 Ywhab Pip5k1b Cdk6 Rhoa Rac1 Prkaca Mark2 Mapk8 Arrb2 IL6%NETPATH%IL6 IL6 Ar Rb1 Hdac1 Map3k7 Hspb1 Akt1 Pik3r1 Fgr Hck Mapk1 Mapk3 Shc1 Ep300 Hsp90aa1 Plcg1 Nlk Stat5a Prkcd Stat5b Btk Cdk9 Lyn Socs3 Map3k4 Pias3 Cd40 Tyk2 Sgk1 Il6st Hnrnpa1 Il6 Crebbp Bmx Jun Eif2a Map2k4 Il6ra Grb2 Nfkb1 Stat3 Cbl Erbb3 Gab2 Vav1 Ptpn11 Daxx Mapk14 Ptk2b Foxo4 Foxo3 Foxo1 Map2k2 Erbb2 Fos Rac1 Eif4ebp1 Gsk3b Fyn Jak1 Pik3r2 Map2k1 Eif4e Stat1 Mapk8 Gab1 Map2k6 Ncoa1 Bad TSH%NETPATH%TSH TSH Creb1 Gnao1 Tshr Hspa5 Canx Atp1a1 Gnai2 Gnai1 Scrib Calr Map2k3 Gnai3 Gnaq Mapk3 Raf1 Lep Map2k6 Igf1r Gna12 Gna11 Ikbkb Gna13 EGFR1%NETPATH%EGFR1 EGFR1 Huwe1 Tjp2 Cavin1 Cavin2 Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Stambp Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Ripk1 Sirpa Ralgds Dlg3 Crim1 Ddx6 Afap1l2 Tgif1 Sfpq Dapp1 Asap1 Iqgap1 Asap3 Anks1 Baiap2 Lsr Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Dock4 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Rgs16 Kras Mta2 Snrpd2 Egf Spry2 Spry3 Spry1 Reps2 Spry4 Pebp1 Ptpn23 Zpr1 Map2k2 Appl1 Dyrk1a Creb1 Hdac1 Pik3r1 Ptk2 Mapk1 Myc Jund Dab2 Sp1 Jun Pik3ca Trp53 Cav1 Stk11 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Gsk3b Crk Pik3r2 Ap2b1 Map2k3 Pard3 Prkd1 Crkl Plcg1 Cblb Plcg2 Prkcd Itsn2 Vasp Arhgef7 Pttg1ip Lyn Tfrc Pik3c2b Kirrel1 Shb Dyrk1b Cltc Nfkb1 Pgam1 Vav1 Vav2 Ldha Prpf4b Pak1 Caskin2 Git2 Mpzl1 Map2k1 Nedd9 Mapk7 Mapk8 Erbin Sdcbp Rela Dok1 Dok2 Pkp4 Flnb Raf1 Abl1 Ptpra Cdk1 Ddx3x Acp1 Nck1 Adam9 Pkm Lck Ywhaz Ubash3b Atp1a1 Ptpn6 Cebpb Ptpn12 Mapk14 Arhgap35 Ptk2b Khdrbs1 Erbb2 Eif4ebp1 Prkaa1 Prkaa2 Fyn Jak1 Nos3 Sh2b1 Egfr Gsk3a Cdk5 Rps6ka2 Socs1 Jak2 Sh3kbp1 Rps6ka1 Kit Prkca Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Pik3cg Ptpn18 Casp9 Erbb3 Gab1 Itch Mapk9 Map3k3 Ywhab Rps6ka5 Irs2 Rhoa Rac1 Plec Dsp Itgb4 Met Pik3r3 Col17a1 Ephb2 Pik3cb Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Prkcg Arhgef4 Jup Socs3 Map3k4 Pias3 Tyk2 Hnrnpa1 Scrib Il17rd Myl12b Mprip Elk4 Gja1 Tfg Ralb Otud6b Araf Frs2 Frs3 Arhgap5 Prkci S100a14 Arap1 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot1 Errfi1 Myo6 Garem1 mt-Co2 Antxr1 Arf4 Braf Clta Cyld Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl2 EG433182 Stx4 Inppl1 Pygb Pdzd11 Gsn Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Ensa Stat2 Pkn2 Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Atxn2 Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Cdh2 Plekhn1 Cfl1 Magi1 Hat1 Pkp2 Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Serpinb3d Abl2 Slc38a2 Ptpre Tnk2 Alb Bcl2 Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Sh3gl3 Epha1 Epha2 Epha4 Itgb1 Dsg2 Ctnnal1 Cd59b Wbp2 Sri Ephb1 Cebpa Ephb3 Ephb4 Ahcyl1 Ptpn1 Slitrk6 Csk Arhgap32 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Arhgap42 App Spart Nectin1 Rps10 Tns4 Scamp3 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Pfn1 Tln1 Rin1 H3c8 Hnrnpr Sdc4 Sdc3 Insr Stam Atp5f1c Usp6nl Slc5a5 Snx5 Tollip Pdcd6ip Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Ptprk Ptprf Dcbld2 Rps27l Git1 Cdv3 Laptm4a Plekha6 Plekha5 Mink1 Actn1 Actn4 Plscr1 Gprc5a Map2k7 Aldoa Ncoa3 Limd1 Cstb Krt18 Krt17 Racgap1 Wasl Cttn Axl Ctnnd1 ID%NETPATH%ID ID Map2k2 Rb1 Psmd4 Fhl2 Tcf7l2 Pax5 Elk1 Elk3 Rbl1 Atf3 Hes1 Id3 Rbl2 Smurf2 Tcf3 Myf5 Mapk1 Elk4 Map2k1 Mapk3 Raf1 Smad3 Cdk2 IL9%NETPATH%IL9 IL9 Mapk3 Tyk2 Kat5 Mapk1 Stat5a Stat6 Stat5b Il9r IL3%NETPATH%IL3 IL3 Creb1 Ywhab Ywhaz Pik3r1 Nfkb1 Ptk2 Ptpn6 Dok1 Prkcb Mapk1 Ppp2ca Prkca Socs2 Bcl2l11 Kcnip3 Gab2 Rara Inpp5d Slc2a1 Shc1 Gata2 Crkl Csf2rb2 Ptprc Fes Foxo1 Hras Rxra Gsk3b Crk Pik3r2 Map2k1 Lyn Prkaca Socs3 Gsk3a Gab1 Bcl2l1 Rack1 Pik3cd Bad IL5%NETPATH%IL5 IL5 Ywhaz Nfkb1 Bax Atf2 Stat3 Hck Cbl Rps6ka1 Syk Raf1 Shc1 Ptpn11 Alox5 Il2rb Crkl Mapk14 Pla2g4a Il5 Sox4 Ptk2b Il5ra Stat5a Stat5b Prkcd Foxo3 Map2k2 Hras Elk1 Unc119 Gsk3b Jak1 Lyn Rapgef1 Ctnnb1 Pik3cg Stat1 Gsk3a Nfkbia Dnm2 Rack1 Jun Socs1 Hcls1 Grb2 Sdcbp Sos1 IL4%NETPATH%IL4 IL4 Akt1 Jak2 Ptk2 Atf2 Mapk1 Ets1 Mapk3 Inpp5d Shc1 Ep300 Plcg2 Prkcd Elk1 Rasa1 Cebpa Cd40 Tyk2 Nfkbia Crebbp Pik3ca Ikbkb Nfkb1 Ptpn6 Stat3 Cbl Cebpb Syk Ptpn11 H3c8 Mapk14 Stam Spi1 Il13 Cxcr4 Il13ra1 Snd1 Chuk Il4 Grk3 Mapk11 Il2rg H3c7 Irs2 Jak1 Mapk8 Ncoa3 Pik3cd Socs1 Bad IL-7%NETPATH%IL-7 IL-7 Akt1 Pik3r1 Stat3 Jak3 Mapk1 Il7r Mapk3 Shc1 Stam Cblb Stat5a Stat5b Foxo3 Foxo1 Map2k2 Il2rg Irs1 Irs2 Il7 Gsk3b Fyn Map2k1 Stat1 Gsk3a Bad NOTCH%NETPATH%NOTCH Notch Kat2b Akt1 Jak2 Pik3r1 Rela Mapk1 Mapk3 Ep300 Skp1 Lef1 Rbx1 Smad1 Hdac2 App Src Nfkb1 Hes1 Stat3 Tcf3 Cul1 Sin3a Fhl1 Mfng Ccn3 Gsk3b Skp2 Sap30 Hes6 Maml3 Notch4 Notch2 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll3 Dll4 Maml1 Ring1 Maml2 Fbxw7 Furin Jag2 Cirsr Rbpj Yy1 Smad3 Lfng IL2%NETPATH%IL2 IL2 Il15 Creb1 Stat4 Il2ra Ybx1 Ets2 Akt1 Plcb1 Pik3r1 Tert Atf2 Rela Nr3c1 Ccne1 Itm2b Eif3b Il2 Mapk1 Prkcz Nmi Vil1 Ets1 Mknk1 Mapk3 Raf1 Shc1 Mtor Crkl Hsp90aa1 Stat5a Stat5b Cdk2 Bcl2 Elk1 Lyn Socs3 Pik3cg Stam2 Sgk1 Jun Lck Pik3ca Grb2 Sos1 Shb Nfkb1 Ptpn6 Jak3 Cbl Gab2 Vav1 Ptpn11 Il2rb Mapk14 Ptk2b Stam Foxo3 Map2k2 Il2rg Irs1 Irs2 Eif4ebp1 Crk Fyn Jak1 Pik3r2 Map2k1 Pik3r3 Eif4e Mapk8 Pik3cb Pik3cd TSLP%NETPATH%TSLP TSLP Relb Stat4 Akt1 Nfkb1 Rela Stat3 Mapk1 Stat6 Map2k1 Nfkb2 Mapk9 Mapk3 Eif4e Stat1 Mapk14 Mapk8 Nfkbia Stat5a Stat5b RANKL%NETPATH%RANKL RANKL Map3k7 Ptk2 Nfkb1 Rel Nfkb2 Traf3 Tnfsf11 Tab1 Atp6v1e1 Tab2 Sqstm1 Tnfrsf11b Mapk14 Trem2 Mapk8 Traf2 Traf6 Traf1 Traf5 Spi1 Mitf Chuk IL1%NETPATH%IL1 IL1 Rb1 Akt1 Pik3r1 Nfkb1 Atf2 Rela Map2k3 Dok1 Ppp6c Elp1 Mapk1 Mapk9 Mapk3 Tab1 Mapk14 Pla2g4a Peli1 Ube2v1 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Chuk Myd88 Il1a Fbxw5 Map3k2 Il1b Peli2 Il1r2 Il1r1 Il1rn Rel Pik3r2 Tab3 Tab2 Mapk8 Traf6 Nfkbia Map2k6 Jun Ikbkb Map3k14 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Hkdc1 Taldo1 Pgd Tkt Hk2 Hk1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Mtr Mthfd2 Dhfr Mthfd1l Tyms FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Gale Galt Aldob Aldoc Hkdc1 Aldoa Khk Hk2 Hk1 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Tab1 Mapk11 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Rac2 Kdr Akt1 Rac3 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3ca Nos3 Il10 Ikbkb Il11 Mapk7 Spi1 Irs1 Cxcr1 Stat6 Il15 Cxcr2 Stat4 Il13 Il18 Il2ra Il2rb Irs2 Il15ra Mapk6 Sla2 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Il20ra Fos Il23a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos2 Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Mtor Srf Il2 Il4 Elk1 Il6 Il5 Il7 Il9 Il21 Il12rb1 Mapk15 Il12rb2 Spic Mapkapk2 Il1a Stat5a Stat5b Il6ra Il4ra Stat3 Stat2 Mknk2 Stat1 Mknk1 Chuk Cdkn1a Cdkn1b Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 Pik3cb FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Rfk Flad1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Qars1 Hmbs Rsad1 Fech Eprs1 Cpox Urod Cox10 Ppox Ears2 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Gng2 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Gnb1 Chrna4 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per2 Per1 Per3 Cry1 Cry2 Clock Csnk1d Csnk1e Bmal1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Mvk Pmvk Ggps1 Hmgcr Mvd Pdss1 Fdft1 Lss Sqle Fdps IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm3 Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Gria1 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Stx11 Grin2b PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Cinp Ccnd2 Ccnd3 Ccne1 Rpa3 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pik3cd Mapk12 Trp73 Pik3ca Atm Mapk13 Mapk14 Pik3c2b Pik3c2a Hras Cdkn1a Mapk11 Pik3c3 Pdpk1 Akt1 Akt3 Akt2 Nras Ccne1 Ccng1 Ctnnb1 Trp63 Kras Pik3r1 Ppp2cb Pik3r2 Rb1 Pik3r3 Ppp2ca Trp53 Tpte Pten Pik3c2g Rbl1 Pik3cg Cdk2 Pik3r5 Pik3cb Siah1a THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Hrh1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Prkce Prkca Prkcz METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Prkx Prkacb Grina Grm1 Grik1 Plcb4 Grm5 Homer1 Gna11 Grin2d Grin2c Grin2a Grin2b Prkaca Prkcb Grin1 Gnaq Itpr1 Prkar1a Prkar1b Grik5 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Mapk12 Mapk13 Myc Mapk14 Eef2k Mapk9 Jun Map2k4 Mapk8 Max Ddit3 Mef2c Txn Mknk2 Stat1 Map2k3 Mknk1 Bcl2 Mapk11 Pla2g4a Elk1 Map2k6 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Gng2 Adcy2 Prkaca Kcnk9 Gnao1 Adcy7 Prkar2a Prkar2b Gnb1 Htr1d Htr1f Gnai2 Gnai1 Htr1b Htr1a Gng11 Gnai3 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Prkce Prkca Oxtr Prkcz 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gng2 Gng10 Adcy2 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Htr4 Gnal Gng12 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Uba7 Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2e1 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2v2 Ube2k Uba6 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb2 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Kat5 Wnt5a Cdh1 Trpc1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Fzd10 Wnt10a Bace2 Wnt10b Bace1 Acta1 Acta2 Gsk3b Actb Actr2 Notch4 Ern1 Notch1 Ctnnb1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Fstl1 Lrp1b Wnt16 Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Cd44 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Trim3 Jup Fzd5 Trim2 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Rbpj Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh4a1 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Il4i1 Aldh1l1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Trp73 Trp63 Mdm2 Mdm4 Cop1 Trp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank2 Pank4 Ppcs Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Pik3cd Pik3ca Nfkbil1 Cd22 Vav3 Syk Vav1 Vav2 Map2k2 Map3k3 Map3k2 Map2k1 Blnk Hras Btk Ikbkb Cd79a Cd79b Ptpn6 Lyn Ptprc Ppp3ca Ppp3cb Nfkbia Cd19 Grb2 Mapk10 Fos Sos2 Sos1 Mapk12 Mapk13 Mapk14 Chuk Mapk11 Mapk1 Itpr3 Mapk3 Itpr2 Itpr1 Rac2 Rac1 Araf Mapk9 Plcg2 Jun Mapk8 Nras Prkcb Prkcd Raf1 Pik3cg Pik3cb P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt1 Trp73 Prkag1 Akt3 Akt2 Trp63 Ppp2cb Ppp2ca Tsc2 Trp53 Eif4ebp1 Tsc1 Igbp1 Prkaa1 Prkab2 Prkaa2 Rps6kb2 Prkab1 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Liph Dagla Lpl Pla1a Plcb3 Plcb2 Plcb1 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Gmds Pmm2 Gmppb Pmm1 Mpi MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Akt1 Akt3 Akt2 Txn Rorc Arnt Txn2 Crebbp Egln2 Egln3 Vhl Mtor Hif1a THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Creb3l4 Polr2e Creb3l1 Polr2f Ttf2 Creb3l2 Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2h4 Psmc3ip Gtf2f2 Gtf2h3 Gtf2f1 Brf2 Tbp Brf1 Tbpl2 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Prkar1a Taf4 Prkar1b Taf2 Gtf2e2 Prkar2a Prkar2b Crebbp Gtf2a1l Polr2c Taf1c Taf9 Ep300 Creb3l3 Polr2h OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 Glul UNTITLED%PANTHER PATHWAY%P00019 untitled Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Mapk1 Pla2g4a Itpr3 Mapk3 Itpr2 Itpr1 Prkar1a Prkar1b Akt1 Prkacb Araf Prkcq Adcy2 Prkcg Prkch Ednrb Prkci Ednra Prkaca Adcy3 Prkcb Adcy4 Adcy1 Adcy7 Adcy8 Prkcd Adcy5 Prkar2a Adcy6 Prkce Prkar2b Adcy9 Prkca Edn1 Raf1 Edn2 Edn3 Adcy10 Gucy1b1 Prkg2 Prkg1 Gucy1a1 Gnal Gucy1a2 Prkcz HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Gch1 Fpgs Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Htr2c Htr2b Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Gnb1 Prkce Prkca Gng11 Prkcz Htr2a INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Braf Pik3c3 Mapk3 Rac2 Rac1 Araf Mapk9 Mapk8 Nras Map2k3 Raf1 Pik3r1 Pik3r2 Pik3r3 Pxn Pik3cg Pik3cb Pik3cd Pik3ca Col14a1 Map3k5 Itgbl1 Pik3c2b Crkl Pik3c2a Arfgap1 Ptk2 Col10a1 Map2k2 Col1a2 Col5a2 Map2k1 Col5a3 Hras Dmbt1 Col5a1 Col9a2 Col9a3 Col9a1 Lama5 Arpc1b Arpc1a Lama1 Lama2 Lama3 Lama4 Flnb Tln1 Vcl Vasp Col17a1 Mapk6 Col13a1 Fn1 Itga7 Arl1 Itga8 Itga5 Itga6 Itga9 Itga3 Itga4 Elmo2 Itga1 Itga2 Elmo1 Itga10 Itga11 Col4a3 Actb Col4a4 Arpc3 Col4a1 Cav1 Arpc2 Sos2 Col4a2 Sos1 Col8a1 Shc1 Col4a5 Col8a2 Col4a6 Arpc5 Parvb Parva Rap2b Col16a1 Rap2a Arf1 Rap2c Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rhob Rnd1 Itgam Asap1 Itgae Itgal Arhgap10 Rap1a Col3a1 Rap1b Actg1 Itgad Itgb8 Itgb6 Itgb7 Itgb1 Actbl2 Itga2b Itgb4 Rras Actn2 Itgb5 Itgb2 Actn1 Col20a1 Actn4 Crk Arf6 Arpc5l Arhgap26 Col15a1 Col11a1 Col11a2 Src Ntn4 Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Flna Col6a1 Col6a2 Ptk2b Col6a3 Lims2 Lamc3 Rapgef1 Lamc1 Lamc2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap6 Arhgap5 Arhgap4 Erf Erg Vav3 Arhgap9 Shc3 Vav1 Rasa2 Vav2 Rasa1 Map3k2 Rasa4 Pdgfrb Pdgfra Pdgfa Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Grb2 Jak2 Jak1 Mapk10 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Rps6kb2 Elf1 Elf2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Mycbp Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Srf Elk1 Map3k4 Pik3r5 Mapkapk2 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Mapk1 Braf Ets1 Itpr3 Pik3c3 Mapk3 Itpr2 Itpr1 Plcg1 Araf Plcg2 Jun Mapk8 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Mapk7 Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Mapk15 Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Arhgap10 Arhgap26 Ehf Srgap1 Srgap3 Rab11b NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Acta1 Acta2 Actb Slc44a3 Actr1a Myo3a Actr1b Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh1 Myh2 Myh3 Myh15 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myh14 Myh13 Myo1g Myo1f Plekhh3 Myh10 Myo18a Myo6 Actg1 Myo18b Myo5a Myo9a Slc5a7 Actbl2 Chrnd Actc1 Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Myo15a Myo16 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Jak3 Stat5a Stat4 Jak2 Stat5b Jak1 Stat3 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Phgdh Psph Psat1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3cd Pik3ca Pik3c2b Pik3c2a Vasp Rac2 Ntn1 Rac1 Ntn3 Nfatc4 Plcg1 Rhou Nfatc3 Ntn4 Nfatc2 Plcg2 Ablim1 Dcc Ntng1 Unc5b Unc5d Unc5c Pik3r1 Pik3r2 Pik3r3 Pik3cg Pik3r5 Pik3cb ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a15 Slc6a17 Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc18a2 Slc6a3 Slc6a19 Slc6a18 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Fmo3 Ugt1a2 Cyp2a5 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat2a Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Pak4 Arpc1b Tubb5 Arpc1a Tubb6 Tubb3 Tubb1 Wasl Mylk Limk1 Arpc4 Rock2 Tubb4b Rock1 Tubb4a Acta1 Acta2 Actb Arpc3 Myo3a Arpc2 Myo3b Arpc5 Myh1 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Rhoc Myh11 Myh14 Myh13 Myh10 Actg1 Actbl2 Actc1 Rac2 Rac1 Rhou Diaph2 Diaph1 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Map2k2 Rasa1 Rps6ka4 Rps6ka5 Map2k1 Irs1 Mapk1 Irs2 Mapk3 Ins2 Insr Rps6kb2 Irs4 Igf2r Igf2 Igf1 Insrr Igf1r Fos Rps6ka3 Map2k3 Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Raf1 Elk1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Jak2 Ifng Jak1 Ifngr1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Nme4 Uck1 Uck2 Adat2 Uckl1 Upp1 Uprt Upp2 Nme3 Nme2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Grin2a Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Gria1 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Cacna1e Cacna1a Cacna1b Grm4 Grm7 Grm8 Vti1a Stx1b Cacnb1 Stx1a Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Grm1 Grm5 Prkaca Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Adcy10 Gnai3 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Pik3cd Pik3ca Casp9 Map3k5 Ikbkb Nfkbia Mapk10 Igf2r Akt3 Akt2 Fos Trp53 Atf2 Eif2ak2 Birc3 Birc2 Tnf Madd Bcl2l11 Tnfrsf1b Tnfrsf1a Map2k4 Tradd Nfkb2 Nfkb1 Traf2 Bcl2l1 Chuk Xiap Endog Tnfsf10 Rela Relb Map3k1 Apaf1 Mapk1 Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Atf4 Mapk3 Atf3 Jdp2 Aifm1 Gzmb Map2k7 Akt1 Gzmf Map4k4 Map4k3 Fasl Atf6b Cradd Mapk9 Prkcq Bak1 Eif2s1 Jun Mapk8 Prkcg Casp8 Prkch Casp7 Prkra Casp3 Prkcb Bik Map2k3 Ripk1 Bcl2 Map4k2 Prkcd Diablo Bax Prkce Rel Prkca Fas Daxx Map3k14 Pik3cg Pik3cb LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Pik3cd Pik3ca Map2k2 Map2k1 Pak1 Hras Pak3 Pak2 Grb2 Mapk10 Pdpk1 Gsk3a Akt3 Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Kras Srf Elk1 Map2k6 Map3k4 Atf2 Mapk12 Mapkapk3 Mapk13 Mapk14 Rhoc Mapkapk2 Rhoa Rhob Map2k4 Stat3 Stat1 Mapk11 Map3k1 Mapk1 Braf Ets1 Pik3c3 Mapk3 Rac2 Map2k7 Akt1 Rac3 Rac1 Araf Mapk9 Jun Mapk8 Nras Map2k3 Raf1 Tiam1 Rala Ralb Exoc2 Pld1 Pld2 Ralgds Rgl1 Pik3cg Pik3cb ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Arrb2 Arrb1 Egr1 Agt Plcb3 Gng10 Map2k2 Map2k1 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Mapk1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Mapk3 Itpr2 Itpr1 Gnb1 Prkca Raf1 Gng11 Elk1 Grk3 Grk2 Agtr1a GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2h4 Gtf2f2 Gtf2h3 Gtf2f1 Brf2 Brf1 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf4 Taf2 Gtf2e2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Trp73 Pik3ca Atm Gadd45g Sin3a Sumo3 Chek2 Gadd45b Gadd45a Wrn Hdac1 Traf2 Sfn Cdkn2a Cdkn1a Mta2 Kat2b Gtse1 Pml Cdk1 Sirt1 Cdc25c Pdpk1 Akt1 Akt3 Akt2 Ccne1 Trp63 Crebbp Mdm2 Mdm4 Trp53 Tpte Pten Ep300 Cdk2 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Trh Vamp8 Trhr Vamp1 Stx3 Vamp3 Cga Cacnb3 Vamp2 Cacnb4 Cacnb2 Snap29 Tshb Snap25 Snap23 Cacna1e Cacna1a Cacna1b Cacnb1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca Prkcz ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b3 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 Hsd17b7 Hsd17b6 Soat2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Ctnnb1 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Ctnnd2 Pcdhga1 Ctnnd1 Pcdhga2 Pcdhga3 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Acta1 Acta2 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Actg1 Tcf7l2 Wnt3 Fzd1 Actbl2 Fzd3 Actc1 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b UNTITLED%PANTHER PATHWAY%P06664 untitled Skil Rela Tgif1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc2 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Cs Fh Pdha1 Pdha2 Suclg1 Mdh1 Ogdh Aco2 Sdhc Pdk2 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin2 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 Mmut LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Abat Dpysl2 Cda Dpysl3 Upb1 Dpysl5 Nt5e Dpys Aldh6a1 Dpyd ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Prkx Prkacb Adrb1 Gng2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Gsk3a Pdpk1 Igf2r Pik3ca Igf2 Igf1 Foxo1 Insrr Igf1r Foxo3 Gsk3b Irs1 Mdm2 Mdm4 Tsc2 Tsc1 Tpte Irs2 Pten Ins2 Insr Irs4 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Prkx Prkacb Hrh2 Gng2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Adrb3 Gng2 Gng10 Adcy2 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Ampd3 Gda Xdh Nt5e METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gng2 Gna11 Gng10 Gna14 Pomc Crh Crhr2 Crhr1 Gng3 Gng4 Gng7 Gnaq Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Mapk12 Mapk15 Mapk13 Mapk14 Mapk7 Mapk11 App Mapk1 Mapk10 Mapk3 Cacnb2 Mapk6 Cacna1c Kat5 Mapk9 Prkcq Mapk8 Bace2 Prkcg Prkch Bace1 Prkci Pkn2 Cacna1f Prkcb Cacna1d Pkn3 Klc1 Prkcd Adam17 Mapk4 Prkce Klc4 Prkca Klc3 Klc2 Psen1 Cacna1s Apba1 Apba2 Psen2 Apba3 Pkn1 Ncstn Cacnb1 Aph1b Prkcz CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Cxcr4 Abl1 Ntn1 Rac1 Ntn3 Rhoc Ntn4 Dcc Ntng1 Cxcl12 Slit1 Srgap1 Slit2 Slit3 Rac2 Robo1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Nme4 Dscaml1 Dhodh Cad Ctps2 Cps1 Ctps1 Nme1 Nme3 Nme2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Pik3cd Pik3ca Map3k5 Pik3c2b Pik3c2a Shc3 Rasa2 Map2k2 Map3k3 Rasa1 Map3k2 Rasa4 Map2k1 Hras Grap Stat6 Erbb4 Stat4 Mapk10 Gab1 Gab2 Akt3 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Pik3r5 Mapk12 Mapk13 Mapk14 Stat5a Stat5b Map2k4 Erbb2 Stat3 Erbb3 Stat2 Mras Stat1 Rasal2 Gab3 Egfr Phldb2 Nf1 Rras2 Mapk11 Dab2ip Prkd3 Pebp4 Mapk1 Spry2 Spry1 Prkd1 Spry4 Braf Pebp1 Prkd2 Rras Pik3c3 Mapk3 Rac2 Map2k7 Akt1 Rac1 Plcg1 Araf Mapk9 Prkcq Plcg2 Mapk8 Prkcg Prkch Prkci Nras Prkcb Map2k3 Prkcd Prkce Prkca Raf1 Shc2 Pik3cg Prkcz Pik3cb PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Mmp1a Plau Serpine1 Serpinf2 Plaur Serpinb2 Fgb Fga Mmp13 Mmp3 Fgg Plat Plg Mmp9 PNAT%PANTHER PATHWAY%P05912 PNAT Gng3 Gng4 Gng8 Vamp8 Vamp1 Gnb2 Stx3 Gnb4 Vamp3 Gnb3 Vamp2 Snap29 Epb41l2 Snap25 Clic6 Prkx Snap23 Ppp1r1b Prkacb Kcnk3 Epb41l3 Slc18a2 Adcy2 Drd1 Drd2 Drd5 Drd4 Ppp1cc Ppp1ca Gnaz Prkaca Kcnk9 Epb41 Adcy7 Prkar2a Prkar2b Gnb1 Flna Gnai2 Gnai1 Slc6a3 Gng11 Gnai3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Fbxw11 Gli1 Btrc Crebbp Gli3 Shh Smo Ptch1 Sufu Stk36 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Slc5a7 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Prkaca Gnao1 Prkar2a Prkar2b Gnb1 Kcnj9 Gnai2 Gnai1 Kcnj6 Slc18a3 Adcy10 Kcnj5 Chrm2 Slc6a8 Gng11 Chrm4 Gnai3 Gnat2 Gnat1 Kcnj3 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gfpt1 Gfpt2 Gnpda1 Amdhd2 Gnpda2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Bmp10 Skil Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Jund Acvr1c Hras Snip1 Lefty1 Tgfb2 Tgfb3 Gdnf Acvrl1 Cited1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Mapk10 Gdf2 Bmpr1a Bmpr1b Gdf3 Gdf6 Bmp7 Gdf5 Bmp6 Bmp5 Gdf7 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Bmp1 Smad4 Smad9 Acvr2a Tll2 Tll1 Gdf15 Inhba Inhbb Crebbp Acvr2b Junb Inhbc Tgfbr1 Smad5 Tgfbr2 Smad6 Gdf11 Inhbe Map3k7 Smad7 Ep300 Gdf10 Atf2 Mapk12 Mapk13 Mapk14 Tab1 Mapk11 Mapk1 Rras Mapk3 Mapk9 Jun Mapk8 Nras BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Kng2 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz F2 Tfpi F3 Serpina10 Thbd F7 F8 F9 Pros1 F2rl3 Itga2b Fgb Fga Fgg Plat Plg Plau Plaur F2r Klkb1 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Pik3ca Casp9 Nos3 Gna11 Gna14 Irs1 Gnaq Gngt2 Ptger1 Gnb2 Foxo4 Gnb4 Gngt1 Gnb3 Gnb5 Ywhaz Insr Rps6kb2 Pdpk1 Akt1 Akt3 Foxo1 Akt2 Foxo3 Nras Gsk3b Gnb1 Sos2 Sos1 Gnai2 Gnai1 Pik3r1 Pik3r2 Pik3r3 Gnai3 Gnat2 Pik3r5 Pik3cb HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Grm3 Grm2 Gsk3a Crebbp Ep300 Creb3l3 Creb3l4 Creb3l1 Creb3l2 Gng10 Hrh1 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gngt1 Adora2b Adora2a Gng12 Adra2c Adra2b Htr6 Prkar1a Htr7 Prkar1b Oprd1 Oprl1 Prkacb Phka1 Phka2 Grm1 Adrb2 Grm5 Adra1b Adra1a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Adcy3 Oprm1 Adcy4 Htr5a Adcy1 Phkb Adcy7 Adcy8 Chrm1 Adcy5 Prkar2a Chrm3 Adcy6 Prkar2b Chrm5 Adcy9 Htr1d Hrh4 Htr1f Hrh3 Gnai2 Adora1 Htr1b Adora3 Htr1a Gnrhr Gys1 Gnai3 Gys2 Htr4 Clta Gnal Cltb Cltc Mtnr1a Creb1 Htr2a Creb3 Htr2c Phkg1 Htr2b Phkg2 Mtnr1b Pygb Pygl Pygm Gpr50 Oprk1 Adrb1 Hrh2 Adrb3 Gsk3b Grm4 Grm7 Grm8 Rap1a Rap1b Gng2 Drd1 Adcy2 Drd2 Drd5 Drd4 Prkaca Gnb1 Gnai1 Kcnj9 Kcnj6 Kcnj5 Chrm2 Chrm4 Kcnj3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Pik3cd Pik3ca Map3k5 Pik3c2b Pik3c2a Shc3 Rasa2 Map2k2 Map3k6 Map3k3 Rasa1 Frs2 Map3k2 Rasa4 Map2k1 Frs3 Hras Fgfr3 Fgfr4 Fgfr1 Ptpn6 Fgfr2 Grap Mapk10 Akt3 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Mapk11 Mapk1 Spry2 Spry1 Spry4 Pebp1 Pik3c3 Mapk3 Rac2 Map2k7 Akt1 Rac1 Plcg1 Araf Mapk9 Prkcq Plcg2 Mapk8 Prkcg Prkch Prkci Nras Prkcb Map2k3 Prkcd Prkce Prkca Raf1 Pik3cg Prkcz Pik3cb ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gng10 Gng3 Cnga3 Gng4 Pdc Gng7 Cnga1 Grk1 Gng8 Pde6g Gngt2 Rho Calml3 Rgs9 Gnb2 Pde6a Gnb4 Gngt1 Pde6b Cngb3 Gnb5 Rcvrn Gng12 Gng13 Gng2 Gnb1 Gnat1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Mapk12 Mapk15 Mapk14 Sfn Mapk7 Mapk1 Mapk10 Ywhaz Mapk3 Psma4 Psma3 Psma6 Psma5 Ccne2 Psma2 Psma1 Cask Ywhah Ywhag Mapk9 Ywhae Th Mapk8 Ywhab Psmb10 Sncaip Psmb7 Prkn Psmb1 Ccne1 Gpr37l1 Septin5 Septin4 Psmb3 Stx7 Septin2 Septin1 Stx12 Slc6a3 Gpr37 Ndufv2 Psma7 Snca Pld2 Elk1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Plcb4 Gna11 Gng10 Grin2a Gna14 Gng3 Gng4 Gng7 Grin1 Gnaq Gng8 Gngt2 Slc5a7 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Prkcq Grin2d Grin2c Prkcg Prkch Grin2b Prkci Pkn2 Prkcb Pkn3 Prkcd Chrm1 Chrm3 Gnb1 Prkce Prkca Slc18a3 Gng11 Pkn1 Prkcz OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Pcna Rfc1 Rfc2 Pola1 Rpa2 Top2b Prim1 Top2a Top1 Dna2 H3-3b Rfc5 Pold2 H3c8 Pold1 Rfc3 Rfc4 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Pccb Mmut Mcee Pcca DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Dscaml1 Nme1 Rrm1 Adsl Nme3 Rrm2 Nme2 Rrm2b Nme4 Ak1 Gmps Ak3 Ak2 Nme5 Ak5 Adss2 Adss1 Ak8 Atic Nme7 Ppat Nme6 Guk1 Gart VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra Vdr Rara Gc F13b HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Oprk1 Grm3 Grm2 Gng13 Cacna1e Cacna1a Cacna1b Grm4 Grm7 Grm8 Plcb4 Plcb3 Rhoa Gna11 Gng10 Gna14 Plcb2 Plcb1 Rap1a Gng3 Gng4 Rap1b Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gngt1 Gnb3 Adora2b Itpr3 Adora2a Gng12 Itpr2 Itpr1 Oprd1 Oprl1 Grm1 Rap1gap Grm5 Rasgrp3 Gng2 Prkcq Rasgrp4 Rasgrp1 Drd1 Sstr5 Prkcg Rasgrp2 Drd2 Drd5 Sstr4 Prkch Arhgef1 Drd4 Sstr3 Prkci Garnl3 Dnajc27 Sstr2 Bdkrb2 Prkcb Sstr1 Bdkrb1 Oprm1 Gpr45 Gnao1 Prkcd Chrm1 Prkce Chrm3 Gnb1 Prkca Chrm5 Adora1 Adora3 Gnrhr Chrm2 Chrm4 Clta Cltb Cltc Prkcz ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Apc2 Epha3 Ephb1 Dll1 Ephb2 Ephb3 Dll3 Dll4 Rasa1 Dlk1 Apc Pdgfrb Tek Pdgfra Pdgfa Pdgfb Grap Nck2 Jak1 Nck1 Ctnnb1 F2r Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Kdr Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Jun Mapk8 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Crkl Pik3c2a Ptk2 Map2k2 Tgfb1i1 Frs2 Map2k1 Frs3 Pak1 Hras Fgfr1 Pak3 Pak2 Wnt5a Akt3 Wnt5b Akt2 Wnt10a Wnt10b Fos Gsk3b Notch4 Notch1 Sos2 Notch2 Sos1 Shc1 Rhoc Rbpjl Rhoa Wnt7b Rhob Dvl1 Dvl2 Stat3 Dvl3 Wnt7a Stat1 Wnt2 Wnt1 Map3k1 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Crk Rbpj Wnt2b Src Grb14 Fgf1 Dok1 Dok2 Dok3 Axin1 Grb7 Pdgfc Tcf7 Pdgfd Efnb1 Pld1 Jag2 Pld2 Efnb2 Jag1 Pla2g4c Pla2g4d Birc5 Angpt1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Rrm2b Nme4 Dscaml1 Adat2 Nme1 Dut Dtymk Rrm1 Nme3 Rrm2 Tyms Nme2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt5 Syt3 Syt2 Syt1 Syt11 Syt12 Syt7 Syt6 Rab3a Vamp1 Stxbp1 Unc13c Unc13b Syt15 Stx2 Unc13d Stx1b Stx1a Snap25 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Arrb2 Egr1 Lyn Ppp3ca Nfkbia Grb2 Jak2 Mapk10 Eif4ebp1 Nr2c2 Clu Ier3 Sp1 Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Ryr2 Ryr1 Hbegf Ryr3 Nos1 Hdac7 Akap1 Cckbr Pparg Gucy2e Arhgef28 Cd38 Ctnnb1 Ptgs2 Camk4 Map2k5 Ptpn11 Tpcn1 Tpcn2 Traf6 Bad Srf Cck Mef2d Gast Elk1 Map3k11 Map2k6 Hspb1 Mapk14 Eif4e Map2k4 Mef2c Mapk1 Pla2g4a Prkd1 Braf Prkd2 Mapk3 Itpr1 Akt1 Prkacb Rac1 Plcg1 Araf Mapk9 Prkcq Jun Nfatc2 Mapk8 Prkch Prkcb Bcl2 Adcy1 Prkcd Prkce Prkca Raf1 Pik3r1 Prkg1 Pxn Creb1 Pik3cb Ptk2 Map2k2 Map2k1 Pak1 Mapk7 Irs1 Odc1 Rock1 Elk4 Cdh1 Pdpk1 Foxo1 Foxo3 Ywhab Fos Rps6ka3 Gsk3b Rps6ka1 Sos1 Shc1 Atf2 Itgav Rhoa Stat3 Bcl2l1 Itgb1 Mmp3 Crk Plau Gng2 Slc18a2 Src Bcar1 Prkaca Casp3 Bax Gnb1 Map3k14 Ptk2b GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Pfkl Pkm EG433182 Pgk1 Pgam2 Gpi Pfkm Hkdc1 Hk2 Hk1 Aldoa Tpi1 Pklr Bpgm Eno2 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Rbpj Rbpjl Ncor2 Dll3 Cirsr Dll4 Dlk1 Maml1 Numb Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Abat Csad Gad1 Aldh5a1 Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Map3k5 Map2k4 Faf1 Parp4 Parp3 Parp2 Parp1 Cflar Apaf1 Lmnb1 Lmnb2 Gsn Fadd Mapk10 Casp6 Capg Lmna Scin Dffb Fasl Mapk9 Jun Mapk8 Casp8 Casp7 Casp3 Fas Daxx INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Vav1 Jund Grap Jak2 Myo3a Myo3b Junb Kras Myh1 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Plcb4 Plcb3 Gna11 Gng10 Vwf Gna14 Myh11 Plcd1 Myh14 Plcb2 Myh13 Plcd4 Plcb1 Gng3 Myh10 Gng4 Gng7 Gnaq Gng8 Mapk1 Plcz1 Plce1 Gnb3 Itpr3 Mapk3 Gng12 Cxcr3 Itpr2 Cxcr5 Itpr1 Cxcr6 Rac2 Cxcl10 Akt1 Prkx C5ar1 Fpr1 Prkacb Ccr10 Rac1 Ccr1 Plcg1 Xcr1 Nfatc4 Araf Ccrl2 Ltb4r2 Nfatc3 Plcg2 Jun Rhog Nfatc2 Fpr-s1 Ccr9 Ccr8 Nras Ccr7 Prkcb Ccr6 Nfatc1 Gnao1 Ccr5 Ccr4 Adcy5 Ccr3 Prkce Adcy6 Ccr2 Cx3cr1 Raf1 Ifnar1 Gnai2 Camk2d Ccl11 Ccl12 Ccl7 Gnai3 Camk2a Ccl5 Ccl4 Ccl3 Ccl2 Pik3cg Pf4 Prkcz Prex1 Pik3cb Cx3cl1 Pik3cd Nfat5 Pik3ca Ccl22 Col14a1 Ccl20 Mylk2 Mylk3 Pak1 Pak6 Ikbkb Pak3 Pak2 Pak5 Pak4 Cxcr1 Arpc1b Arpc1a Cxcr2 Mylk Arpc4 Rock1 Pdpk1 Akt3 Akt2 Cask Ifng Acta1 Acta2 Actb Arpc3 Arpc2 Sos1 Shc1 Arpc5 Il2 Col12a1 Cxcr4 Rhoc Rhoa Nfkb2 Stat3 Itgal Chuk Rela Relb Actg1 Itgb7 Itgb1 Actbl2 Actc1 Rras Col20a1 Arpc5l Gng2 Adcy2 Prkaca Col6a1 Gnai1 Col6a2 Ptk2b Col6a3 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Pnp Hprt1 Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Tubb2b Tubb2a Hip1 Bdnf Ift57 Dync1h1 Grin2a Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Ap2a1 Grin1 Arpc1b Hap1 Tubb5 Arpc1a Hip1r Tubb6 Kalrn Tubb3 Htt Tubb1 Gapdhs Dync1li2 Dync2h1 Dync1li1 Dnai2 Dynll1 Tubb4b Dynll2 Capn9 Tubb4a Capn5 Cyc1 Sp1 Capn7 Grik5 Capn6 Capn1 Capn3 Grik2 Capn2 Grik1 Dnah3 Grik4 Dlg4 Grik3 Dnah5 Grin2d Dnah8 Grin2c Cyfip2 Fos Cyfip1 Grin2b Capns1 Acta1 Capn10 Acta2 Capns2 Actb Capn11 Actr2 Trp63 Crebbp Arpc5 Trp53 Ep300 Trp73 Map2k4 Map3k10 Tbp Actg1 Apaf1 Actbl2 Actc1 Rac2 Taf4 Map2k7 Arpc5l Rac1 Mapk9 Rhog Jun Casp8 Casp3 Cltb ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pcx Pkm Me1 Clybl Pck1 Cs Pdha1 Pdha2 Pklr Acly T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Pik3cd Pik3ca Vav3 Vav1 Vav2 Map2k2 Map2k1 Pak1 Hras Ikbkb Pak3 Pak2 Ptprc Ppp3ca Ppp3cb Nfkbia Nck2 Nck1 Akt3 Akt2 Grap2 Fos Sos2 Sos1 Zap70 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Chuk Map3k1 Mapk1 Braf Pik3c3 Mapk3 Itpr1 Akt1 Rac1 Plcg1 Araf Mapk9 Prkcq Jun Mapk8 Nras Raf1 Pik3r1 Pik3r2 Pik3r3 Pik3cg Pik3cb TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Map3k8 Ikbke Tbk1 Ticam2 Mapk14 Irak4 Ticam1 Ecsit Nfkbie Map2k2 Tollip Irak1 Map2k1 Myd88 Tank Ikbkb Irf3 Chuk Tlr9 Tlr8 Tlr7 Tab1 Tlr6 Tirap Tlr4 Nfkbia Tlr3 Tlr2 Mapk3 Mapk9 Jun Mapk8 Map2k3 Traf6 Elk1 Map3k7 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Pdxk Psat1 Pnpo WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Smarca2 Sag Smarca1 Smarca4 Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Smad1 Smad4 Ctnnb1 Ppp2cb Ppp2ca Smad5 Siah1a Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Nfatc4 Nfatc3 Nfatc2 Gng13 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Tcf7l1 Wnt2 Wnt1 Wnt4 Tcf7l2 Wnt3 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Axin1 Arrb2 Arrb1 Hdac1 Ppp3ca Ppp3cb Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Crebbp Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Ep300 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Prkcq Pcdha12 Pcdh1 Prkcg Cdh19 Prkch Pcdh11x Prkci Cdh17 Cdh16 Prkcb Cdh15 Nfatc1 Cdh13 Cdh12 Prkcd Cdh11 Cdh10 Prkce Prkca Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Prkcz Pcdhga3 Gsk3b Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Gng2 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Tle3 Fbxw11 Tle2 Gnb1 Btrc Tle1 Ctnna3 Ctnna2 Ctnna1 Tle6 Bcl9 Csnk1g3 Hdac3 Csnk1g2 Hdac2 Csnk1d Tbl1xr1 Csnk1e Smarcb1 Hdac8 Csnk2b ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Pnp Hprt1 Xdh Aprt Ada TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gng10 Grm3 Grm2 Gng3 Gng4 Gng7 Gng8 Gngt2 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Gnb5 Vamp2 Snap29 Prkar1a Snap25 Prkar1b Prkx Snap23 Prkacb Prkaca Gnao1 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Cacna1e Adcy10 Cacna1a Cacna1b Gng11 Gnai3 Gnat2 Stx1b Cacnb1 Stx1a UNTITLED%PANTHER PATHWAY%P05916 untitled Gng2 Avp Oxt Gng10 Oprk1 Adcy2 Gnao1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Pdyn Gng8 Gngt2 Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 Gng12 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Rac1 Rhoa Arhgef1 Pak1 Fyn Nrp1 Dpysl4 Plxnb1 Sema3a Dpysl2 Sema4d Cdk5 Fes Crmp1 Dpysl5 Frk Dpys Rac2 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Grm1 Grm5 Plcb3 Plcb2 Plcb1 Gnao1 Gng3 Gng4 Gng7 Gnb1 Gng8 Gngt2 Gnai1 Cacna1a Gnb2 Cacna1b Gnb4 Gng11 Gnb3 Gnai3 Cacna1g Cnr1 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Taf1b Polr1d Polr2k Cavin1 Ubtf Ttf1 Psmc3ip Tbp Tbpl2 Tbpl1 Taf8 Taf1c Rrn3 Taf1a Polr1b PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pdxk Pnpo SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Adat2 Tk1 Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Prkx Prkacb Adrb2 Gng2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gnal Gng12 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gng10 Gng3 Gng4 Gng7 Pdyn Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Oprd1 Prkx Prkacb Gng2 Penk Adcy2 Prkaca Oprm1 Gnao1 Adcy7 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gnai3 Gnal Creb1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb4 Plcb3 Adra1b Gna11 Adra1a Adra2a Prkcg Plcb2 Plcb1 Prkcd Prkce Prkca Plce1 Adra2c Adra2b Itpr1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ace Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Egln2 Pdha1 Egln3 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway P2ry2 Plcg1 Ptk2b Prkca Prkcb THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Cmpk1 Cant1 Galt Slc35a2 Nme2 Slc2a1 Lalba Ugp2 B4galt1 G6pc1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Mapk14 Cd40 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Dusp1 Cd40lg Nfkb1 Chuk Tnfaip3 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Mtor Isyna1 Vac14 Becn1 Sacm1l Inpp1 Pik3cb Pik3r4 Plcb4 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ace Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Akr1b1 Pdhb Grhpr Pklr Dlat Mdh1 Dld Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Hagh Pcx Acyp1 Acot12 Pck1 Acat1 Pdha1 Acaca CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Cyp2c65 Cyp3a16 Aldh1a1 Gstm2 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh D2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Hras Lat Prkcb Plcg1 Prkca Mapk8 Shc1 Ptpn7 Cd3g Cd247 Elk1 Map2k7 Cd3d Mapk3 Calm1 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfkbia Nfat5 Map3k1 Map2k1 Lck Nfkb1 Grb2 Rasgrp1 Pik3r1 Raf1 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Cbr1 Nos3 Abcb1a Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Akr1a1 Ndufs7 Xdh Cbr3 Akr1c18 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Hal Sds Gldc Aqp8 Asrgl1 Asns Amt Cps1 Glul Dld Gls2 Glud1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Hras Prkca Mapk3 Cacna1c Itpr1 Plcb1 Rela Nfkbia Map2k1 Cacna1f Nfkb1 Cacna1d Mapk1 Cacna1s Prkcb Raf1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacna1a Ins2 Cacnb1 Slc2a2 Cacna2d2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Chit1 Gnpda1 Hexa Hk1 Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pip5k1a Pip4k2a Pi4ka Pikfyve Vac14 Becn1 Pik3r4 Inpp5d Inpp5e Erbb2 Synj1 Inpp4b Plcb1 Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Pik3r1 Pik3cd PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mpc1 Gpi Tpi1 Mdh2 Aldoa Hk2 Pank4 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Pck1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Aldoa Fbp1 Rpe Taldo1 Prps1l1 Pgd Rpia Dera Pfkl G6pdx Pgls Tkt Rbks Pgm1 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2b Mat2a Srm Odc1 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ace Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Ldhd Hagh Glo1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmds Tpi1 Aldoa Akr1b1 Fbp1 Pfkl Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkfb1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Tyms Rrm2b Dck Nme1 Dctd Nt5c Slc28a3 Slc29a1 Ctps1 Slc28a1 Cmpk1 Rrm1 Rrm2 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Cyp3a16 Cyp2c50 Nqo1 Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Comt Kcna5 Atp1b2 Cyp2e1 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Pdia2 Kcnj3 Sdf2l1 Kcnj2 Hyou1 Dlg1 Pdia6 Abcc8 Pdia4 Kcnj11 Ppib Abcc9 Dnajb11 Cacna2d2 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Cmpk1 Cant1 Galt Slc35a2 Nme2 Slc2a1 Lalba Ugp2 B4galt1 G6pc1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cant1 Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cad Nme6 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Hadh Echs1 Acadl Acads Acat1 Acaa2 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp2d22 Sult1a1 Fmo1 Ugt1a9 Fmo3 Cyp3a16 Esr1 Ugt1a5 Cyp2b10 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl4 Rps14 Rps16 Qars1 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc1 Abcc2 Abcc3 Tuba1b Trp53 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat Cyp3a16 Aldh1a1 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ace Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cant1 Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cad Nme6 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Tyr Dct PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Fah Il4i1 Gstz1 Tat Yars1 Hpd Got1 Farsa Hgd Farsb NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Fbp2 H6pd Prpsap1 Tktl1 Pfkm Rpe Taldo1 Pgd Rpia Dera Rbks Aldob FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Aldoa Hk2 EG433182 Pgam2 Pfkm Galm Pklr G6pc1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmds Tpi1 Aldoa Akr1b1 Fbp1 Pfkl Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkfb1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ace Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Creb1 Gngt1 Fshr Gnb1 Prkacb Cga Gng12 Ppp1ca Adcy2 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Th Ddc Pnmt GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Ptpmt1 Gpam Gpd1 Crls1 Cds2 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Mpc1 Gpi Tpi1 Mdh2 Aldoa Hk2 Pank4 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Pck1 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp2d22 Slc22a1 Ugt1a9 Cyp3a16 Abcc2 Cyp2b10 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79b Hras Lyn Orai1 Blnk Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Mapk3 Calm1 Rac1 Ppp3ca Jun Ppp3cb Syk Fos Nfat5 Map3k1 Map2k1 Lck Grb2 Raf1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Chrm1 Gngt1 Gnaq Tub Gnb1 Htr2c Plcb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl4 Eprs1 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a Farsa Farsb LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ace Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Bpgm Gpi Slc2a2 Pgam1 Aldoa Hk2 EG433182 Pgk1 Pgam2 Pfkm Galm Pklr G6pc1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Abcb1a Abcg2 Abcc1 Sult1e1 Sult2a1 Abcc4 Abcc5 Ugt2b36 Gstt1 Cyp2d22 Sult1a1 Cyp3a16 Cyp2a5 Cyp2e1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Sds Bckdhb Pcca Bckdha Pccb Dbt Dld Mmut METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Aldh1l1 Mthfsl Fpgs Mthfd1 Mthfd2 Ftcd CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Cyp2d22 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp3a16 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl4 Aars1 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc1 Abcc2 Abcc3 Tuba1b Trp53 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Ndufa1 mt-Co1 ATP6 Sdhd Atp5f1d Uqcrc1 Sdhc Atp5pb Sdhb Atp5f1c Sdha Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Nqo1 Ggcx Vkorc1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp1a2 Scn1b Cyp3a16 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Hlcs Acacb Spcs1 Btd CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Asl Otc Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Cps1 Ass1 Gls2 Glud1 Slc25a15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ace Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Hk1 Gale Akr1b1 Pgm1 Galt Glb1 Gaa Lct Gla Ugp2 B4galt1 G6pc1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Cyp3a16 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Hadh Echs1 Acsm1 Hmgcl Acads Acat1 Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Gclc Gclm Nagk Gnpnat1 Gfpt1 Got2 Gpt Abat Aldh4a1 Gmps Cps1 Glul Qars1 Gad1 Gss Cad Gls2 Gsr Ppat Glud1 Ears2 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Mvk Fdft1 Lss Sqle Pmvk Fdps Hmgcr Acat1 Idi1 Mvd BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Tpi1 Pfkp GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pgs1 Ptpmt1 Gpam Gpd1 Cds1 Crls1 Pla2g2d Ptdss1 Ptdss2 Gde1 Pisd Phospho1 Pld2 Plpp1 Pcyt1a Pla2g15 Lypla1 Chat Dgka Pemt Chka Agpat1 Gpd2 Cdipt FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfd C3 C5 C6 C9 Cfp C8a Cfb NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp2d22 Cyp3a16 Cyp2c50 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sptlc2 Degs2 Enpp1 Gba1 Ugt8 Samd8 B4galt2 Sphk2 Ugcg Sdr16c5 Gla Acer2 Sptlc1 Cerk HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Mpc1 Gpi Tpi1 Mdh2 Aldoa Hk2 Pank4 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Pck1 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Tyrp1 Cat Sod3 Sod2 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Abcb1a Abcg2 Abcc1 Abcc2 Bche Pdia2 Sdf2l1 Ces2h Hyou1 Ces1d Top1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Cyp3a16 Ugt1a1 Hspa5 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg Serpinc1 F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ace Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc1 Cyp3a16 Abcc2 Abcc3 Tuba1b Trp53 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Hras Ins2 Plcg1 Prkca Shc1 Mapk3 Socs1 Irs1 Insr Ptpn6 Ghr Stat5a Stat5b Rps6ka1 Map2k1 Slc2a4 Sos1 Grb2 Jak2 Mapk1 Raf1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Slc4a1 Atp1b1 Atp1b3 Atp1b2 Scnn1a Scnn1b Scnn1g Ca1 Atp1a2 Atp1a1 Atp1a3 Slc14a2 Aqp3 Aqp2 Atp6v1b1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Akr1b1 Pdhb Grhpr Pklr Dlat Mdh1 Dld Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Hagh Pcx Acyp1 Acot12 Pck1 Acat1 Pdha1 Acaca DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Ptpmt1 Vac14 Pik3c3 Prex1 Inpp5f Plce1 Inppl1 Zfyve16 Pik3cd Pik3r4 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Vars1 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Casp7 Casp3 Casp6 Sptan1 Map2k4 Lmna Fas Fadd Dffa Daxx Dffb Mapk8 Faf1 Arhgdib Map3k7 Pak1 Jun Ripk2 Prkdc Fasl Parp1 Cflar Map3k1 Pak2 Ptpn13 Lmnb1 Lmnb2 Casp8 Rb1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Tubb1 Abcb1a Abcg2 Abcc1 Abcc2 Slco1b2 Tuba1b PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Mpc1 Agxt Gpt Pcx Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Nrg2 Adam17 Prkca Erbb4 Erbb3 Psen1 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ace Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Fgb Fga Col1a1 F10 F12 Fgg Serpinc1 F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Ugt1a2 Cyp2u1 Ugt2b1 Alox5 Slc22a8 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp3a16 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2c50 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Slc22a6 Alox12b Ptgs2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc22a2 Slc22a6 Ca1 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Slc4a4 Slc9a1 Slc7a8 Slc7a9 Slc6a20a Aqp1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Hras Plcg1 Mapk8 Shc1 Elk1 Mapk3 Jun Ptpn6 Epo Fos Stat5a Epor Map2k1 Sos1 Grb2 Jak2 Raf1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Oprm1 Cyp2d22 Cyp3a16 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Casp7 Gclc Oplah Gclm Gpx1 Ggt6 Gss Gsto2 Gsr Anpep GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sptlc2 Acer1 Degs2 Arsa Sgpl1 Gba1 Ugt8 Gal3st1 Acer3 Enpp7 Sphk2 Galc Ugcg Neu3 B4galt6 Sgms1 Kdsr Plpp1 Sgpp2 Glb1 Gla Sptlc1 Cerk GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Aldh6a1 Abat Upb1 Dpys Gad1 Aoc3 Aldh2 Cndp1 Dpyd PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Cacna1a Cacnb1 Slc2a2 Prkca Chrm3 Adcy10 Vamp2 Abcc8 Rab3a Rapgef4 Gng2 Glp1r Cacna2d2 Gnaq Camkk1 Gnb1 Itpr3 Plcb1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Creb1 Gngt1 Gnb1 Htr6 Prkacb Ppp1ca METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp3a13 Oprm1 Cyp2d22 Grin2a Cyp2c65 Cyp3a16 Cyp2c50 Grin1 Cyp2b10 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Mat2b Mat2a Ahcy Mettl6 Scly Sephs2 Slc39a8 Cbs Papss1 Mars1 Cth Ggt1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gngt1 Gnb1 Prkacb Ptgdr Adcy2 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gpi Hk1 Gys1 Ganab Hkdc1 Pgm2 Gbe1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Fah Il4i1 Gstz1 Tat Yars1 Hpd Got1 Farsa Hgd Farsb FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Gng2 Gnb1 Itpr1 Plcb1 Srf Akt1 Adcy1 Rock1 Lpar4 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Chit1 Gnpda1 Hexa Hk1 Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Crot Acsl1 Pex11g Slc25a20 Abcd2 Abcd1 Cpt2 Pex14 Crat Pex13 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sptlc2 Acer1 Degs2 Arsa Sgpl1 Gba1 Ugt8 Gal3st1 Acer3 Enpp7 Sphk2 Galc Ugcg Neu3 B4galt6 Sgms1 Kdsr Plpp1 Sgpp2 Glb1 Gla Sptlc1 Cerk 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Akr1d1 Hsd17b1 Cyp19a1 Sult1e1 Cyp17a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Asl Otc Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Cps1 Ass1 Gls2 Glud1 Slc25a15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Adsl Asl Il4i1 Nars1 Adss1 Ddo Aspa Dars1 Abat Asrgl1 Asns Ass1 Gad1 Cad CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Hras Prkca Itpr1 Plcb1 Rela Nfkbia Map2k1 Nfkb1 Mapk1 Mapk3 Prkcb Raf1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Haao Mif Dbh Tyr Fah Comt Dct Cyp2e1 Cat Aldh1b1 Aldh2 Acss2 Acss1 Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Hras Ins2 Plcg1 Prkca Shc1 Mapk3 Gh Irs1 Ptpn6 Ghr Stat5a Stat5b Rps6ka1 Map2k1 Slc2a4 Grb2 Jak2 Mapk1 Raf1 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Mpc1 Agxt Gpt Pcx Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Galk1 Gck Ugdh Gale Pgm1 Galt Uxs1 Ugp2 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Plcg1 Pik3cg Pik3r6 Prkca Vav1 Plcb1 Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nqo1 Nmnat1 Nampt Ppargc1a Rora Npr1 Sirt1 Nmnat3 Clock Nmnat2 Nadk CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Ppox Cox10 Flvcr2 Alad Cox15 Gusb Hmbs Ftmt Cpox Urod Alas1 Fech Uros Hmox1 Blvra EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Creb1 Gngt1 Gnb1 Prkacb Htr7 Ppp1ca PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Asl Otc Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Cps1 Ass1 Gls2 Glud1 Slc25a15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Cyp2c65 Ptgs1 Slc22a6 Ptgs2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ugt1a2 Ppib Dnajb11 Ugt2b1 Slc22a8 Ugt1a9 Erp29 Cyp3a16 Ugt1a1 Hspa5 Cyp2c50 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Gpi Pkm Tpi1 Pgam1 Pfkp Hk1 EG433182 Pgam2 Galm Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp2d22 Cyp1a2 Cyp3a16 Slc6a2 Cyp2c50 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cyp2d22 Cyp3a16 Cyp2c50 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Cyp1a2 Htr1a KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna4 Ugt1a9 Fmo3 Chrnb2 Ugt1a5 Chrna3 Aox1 Cyp2b10 Cyp2a5 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Bbox1 Aldh9a1 Shmt1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Lpl Plpp2 Gpam Gpd1 Agpat1 Akr1b1 Aldh3a1 Gpd2 Plpp1 Glyctk Lipc ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Gclc Gclm Nagk Gnpnat1 Gfpt1 Got2 Gpt Abat Aldh4a1 Gmps Cps1 Glul Qars1 Gad1 Gss Cad Gls2 Gsr Ppat Glud1 Ears2 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Abcc4 Nudt2 Abcc5 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Adk Dguok Rrm1 Tpmt Rrm2 Slc29a2 Ak1 Slc28a2 Gmps Gmpr Adss2 Pfas Atad1 Atic Aox1 Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Slc28a3 Slc29a1 Prps1l1 Rac1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak1 Ak2 Nme1 Nme2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Abcc4 Nudt2 Abcc5 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Adk Dguok Rrm1 Tpmt Rrm2 Slc29a2 Ak1 Slc28a2 Gmps Gmpr Adss2 Pfas Atad1 Atic Aox1 Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Slc28a3 Slc29a1 Prps1l1 Rac1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Gclc Gclm Ldha Mpst Ctns Cdo1 Cars1 Got1 Cth MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Hras Map2k4 Srf Rasa1 Egfr Sos1 Stat6 Jak1 Egf Prkcb Stat3 Stat2 Plcg1 Stat1 Prkca Mapk8 Shc1 Elk1 Mapk3 Jun Fos Map3k1 Map2k1 Grb2 Raf1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Aldh1l1 Mthfsl Fpgs Mthfd1 Mthfd2 Ftcd FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Pdxk Alpl Pdxp Pnpo Aox1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Hk1 Ugdh Galk2 Gale Pgm1 Galt Uxs1 Ugp2 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ace Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Casp7 Gclc Oplah Gclm Gpx1 Ggt6 Gss Gsto2 Gsr Anpep PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Mars1 Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tyms Tymp Cda Slc28a1 Ces1d DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Enpp1 Tyr Flad1 Rfk ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Cacna1a Ugt2b36 Atp1a2 Atp1a1 Ugt1a2 Ugt2b1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Pdia2 Slc6a4 Sdf2l1 Slc6a3 Hyou1 Adra1a Pdia6 Scn10a Pdia4 Pcsk2 Ppib Chrna4 Dnajb11 Oprm1 Cacna2d2 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Hadh Echs1 Acadl Acads Acat1 Acaa2 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Asl Otc Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Cps1 Ass1 Gls2 Glud1 Slc25a15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Agpat1 Gnpat Cept1 Agps Plpp1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult2b1 Sult1a1 Chst11 Bpnt1 Suox Papss2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ace Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2d22 Ugt1a9 Cyp3a16 Ptgs1 Ptgs2 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak1 Ak2 Nme1 Nme2 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Treh Atp1a2 Slc5a1 Atp1a1 Slc2a2 Gck Atp1b1 Atp1b3 Atp1a3 Atp1b2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Akr1b1 Pdhb Grhpr Pklr Dlat Mdh1 Dld Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Hagh Pcx Acyp1 Acot12 Pck1 Acat1 Pdha1 Acaca HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Cyp3a13 Maob Cyp2d22 Maoa Aox1 Cyp2c50 Slc6a4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc2a2 Gpt2 Gpt Slc25a22 Slc1a4 Slc2a4 Glud1 Slc38a4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Tyms Rrm2b Dck Nme1 Dctd Nt5c Slc28a3 Slc29a1 Ctps1 Slc28a1 Cmpk1 Rrm1 Rrm2 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Suclg1 Mpc1 Suclg2 Slc2a2 Fh Idh1 Idh3a Dlst Pgk1 Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc1a5 Gls2 Glud1 Gpi Pkm Hk2 EG433182 Pgam2 Pklr Taldo1 Mdh1 Pgd Rpia Pfkl Ldha G6pdx Pgls Pcx Slc16a1 Tkt Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Aldob Pdha1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Chit1 Gnpda1 Hexa Hk1 Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Suclg1 Mpc1 Suclg2 Fh Idh1 Idh3a Pgk1 Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 Gpi Pkm Pfkp Hk2 EG433182 Slc2a1 Taldo1 Mdh1 Pgd Rpia G6pdx Pcx Tktl2 Pdha2 Sdhb Slc16a4 Sdha Slc1a2 Cs Dhtkd1 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Chit1 Gnpda1 Hexa Hk1 Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Msmo1 Nsdhl Dhcr24 Ebp Dhcr7 Lbr Sc5d Cyp51a1 Hsd17b7 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Mtor Tyk2 Jak1 Mapk1 Stat3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Oprm1 Bche Ces2h Ces1d INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Ptpmt1 Ipmk Synj1 Impa1 Isyna1 Vac14 Pik3c3 Becn1 Cct3 Pik3ca Plcb4 Bpnt2 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Vav3 Hras Rala Bad Casp9 Bcl2l1 Pld1 Rhoa Ralgds Ralbp1 Smad3 Smad4 Apaf1 Foxo4 Elk1 Akt1 Mapk3 Rac1 Map2k1 Chuk Pik3ca Raf1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Gng2 Hsd3b6 Gnaq Gnb1 Cyp21a1 Agtr1a Cyp11a1 Cyp11b2 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Gpi Aldoa Fbp1 Rpe Taldo1 Prps1l1 Pgd Rpia Dera Pfkl G6pdx Pgls Tkt Rbks Pgm1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Th Ddc Pnmt ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Gclc Gclm Ldha Mpst Ctns Cdo1 Cars1 Got1 Cth ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b Itgb3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Gng2 Gnb1 Itpr1 Plcb1 Srf Lpar5 Akt1 Adcy1 Rock1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Cyp2c65 Cyp3a16 Aldh1a1 Aldh3a1 Cyp2b10 Cyp2a5 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Hras Ins2 Mapk8 Shc1 Akt1 Irs2 Map2k2 Pdpk1 Pik3cg Pik3r6 Foxo1 Irs1 Insr Map2k1 Slc2a4 Sos1 Grb2 Mapk1 Raf1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Akr1b1 Pdhb Grhpr Pklr Dlat Mdh1 Dld Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Hagh Pcx Acyp1 Acot12 Pck1 Acat1 Pdha1 Acaca PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Lars1 Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ppip5k1 Ipmk Ip6k1 Synj1 Nudt3 Impa1 Isyna1 Bpnt2 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Crot Acsl1 Pex11g Slc25a20 Abcd2 Abcd1 Cpt2 Pex14 Crat Pex13 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Synj1 Impa1 Plcd4 Vac14 Pik3c3 Becn1 Pik3r4 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b Itgb3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Casp7 Gclc Oplah Gclm Gpx1 Ggt6 Gss Gsto2 Gsr Anpep TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a13 Cyp2c65 Cyp3a16 Ephx1 Cyp2c50 Cyp2b10 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Cdk1 E2f1 Cdkn1a Bax Apaf1 Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Rb1 Bcl2 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C1qb C1qa C1rb Serping1 Masp2 C2 C4a C1s2 C1qc Mbl2 Cfd C3 C5 C6 C9 C8a Cfb MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 Psmc6 Psma4 Psmc5 Psma3 Ubc Psma6 Psma5 Psmc2 Psmc1 Psmc4 Psma2 Psmc3 Psma1 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Lpl Plpp2 Gpam Gpd1 Agpat1 Akr1b1 Aldh3a1 Gpd2 Plpp1 Glyctk Lipc GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Hras Pld1 Gna11 Src Fshb Lhb Gnrh1 Gnrhr Erbb4 Hbegf Camk2a Adcy5 Cdc42 Egr1 Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Itpr1 Plcb1 Cga Prkcb Prkca Mapk8 Elk1 Map2k7 Calm1 Jun Map3k1 Map2k1 Grb2 Mapk1 Raf1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Cyp1a2 Cyp2c65 Cyp2e1 Nat1 Cyp3a16 Cyp2a5 Xdh ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cyp2d22 Cyp3a16 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmds Tpi1 Aldoa Hk1 Akr1b1 Fbp1 Pfkl Gmppb Phpt1 Pmm1 Fcsk Mpi Fpgt Sord Gfus Aldob Khk Pfkfb1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Pkm Pfkp Hk2 EG433182 Slc2a1 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Cd79b Hras Lyn Orai1 Blnk Sos1 Cd79a Nfatc4 Nfatc1 Prkcb Nfatc3 Nfatc2 Plcg1 Ppp3cc Btk Prkca Mapk8 Shc1 Elk1 Mapk3 Rac1 Ppp3ca Vav1 Jun Ppp3cb Syk Fos Map3k1 Map2k1 Grb2 Raf1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Gng2 Lpar1 Gnb1 Itpr1 Plcb1 Srf Akt1 Adcy1 Rock1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Bdh1 Hmgcl Acat1 Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Adsl Asl Il4i1 Nars1 Adss1 Ddo Aspa Dars1 Abat Asrgl1 Asns Ass1 Gad1 Cad LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Top2a Mpo Cyp3a16 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pemt Chka Pcyt2 Pisd Cept1 Pcyt1a HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp7 Casp3 Top2a Dffa Gzmb Hmgb2 Endog Cad GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b Itgb3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1a Gngt1 Gnb1 Prkacb Prkaca Prkar2a Prkar2b Prkar1b Adcy10 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Kars1 Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Rpia Prps1 Dera Gpi G6pdx Pfkp Tktl2 Rbks Pgm1 Fbp1 Rpe Taldo1 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1qb C1qa C1rb C3 C5 C6 C2 C4a C9 C1s2 C8a C1qc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Aldoa Hk1 Fbp1 Sord CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacna1a Ins2 Cacnb1 Slc2a2 Cacna2d2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Nt5c2 Enpp1 Pnp Nudt12 Nnmt Qprt Nampt Nmrk1 Bst1 Nnt Nadsyn1 Nmnat2 Nadk Aox1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Ppox Cox10 Flvcr2 Alad Cox15 Gusb Hmbs Ftmt Cpox Urod Alas1 Fech Uros Hmox1 Blvra PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Ppox Cox10 Flvcr2 Alad Cox15 Gusb Hmbs Ftmt Cpox Urod Alas1 Fech Uros Hmox1 Blvra ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Gpi Hk1 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Abcb1a Top2a Mpo Ptgs1 Ptgs2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Cyp3a16 Ugt1a1 Top2b Hspa5 Abcc3 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Abcb1a Crkl Slc22a1 Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Chit1 Gnpda1 Hexa Hk1 Amdhd2 Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Haao Wars1 Tdo2 Aadat Cyp1a1 Kynu Acmsd Ido1 Cat Aldh2 Afmid Aanat Ddc Tph1 Kmo Inmt Wars2 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Pfkp Slc25a1 Myd88 Ly96 Acly Cd14 Tirap Tlr4 Mdh1 Ikbkb Me1 Traf6 Sdhd Ikbkg Sdhc Sdhb Rela Nfkbia Sdha Cs Nfkb1 Chuk Acaca HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Gngt1 Fshr Gnb1 Prkacb Gng12 Avpr2 Adcy2 COAGULATION%SMPDB%SMP0000586 Coagulation Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Acss2 Acss1 Cyp2e1 Cat Aldh1b1 Aldh2 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Lpl Plpp2 Gpam Gpd1 Agpat1 Akr1b1 Aldh3a1 Gpd2 Plpp1 Glyctk Lipc PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Gars1 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Hk1 Gale Akr1b1 Pgm1 Galt Glb1 Gaa Lct Gla Ugp2 B4galt1 G6pc1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Msmo1 Nsdhl Dhcr24 Ebp Dhcr7 Lbr Sc5d Cyp51a1 Hsd17b7 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Fah Il4i1 Gstz1 Tat Yars1 Hpd Got1 Farsa Hgd Farsb VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Tubb1 Abcb1a Abcg2 Abcc1 Abcc2 Slco1b2 Tuba1b SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nqo1 Nmnat1 Nampt Sirt1 Nmnat3 Nmnat2 Nadk Aifm2 Trp53 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Dlst Pdhb Acly Idh3b Aco2 Dlat Dld Mycbp Slc38a5 Got2 Slc1a5 Slc1a4 Gls2 Glud1 Ldha Me1 Slc7a7 Pcx Slc16a1 Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Slc12a6 Atp1a2 Atp1a1 Slc12a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Clcnkb FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Aldh1l1 Mthfsl Fpgs Mthfd1 Mthfd2 Ftcd GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Asl Otc Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Cps1 Ass1 Gls2 Glud1 Slc25a15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl4 Eprs1 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Th Ddc Pnmt SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Agl Pygl Gpi Gck Ugt2b1 Amy2a5 Gusb Hk2 Ugdh Pgm2l1 Ugp2 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Hras Plcg1 Ptk2b Crk Mapk3 Cxcl12 Pxn Gngt1 Pik3c2g Gnaq Ptk2 Gnb1 Bcar1 Cxcr4 Nfkbia Gnai1 Map2k1 Nfkb1 Mapk1 Raf1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Agl Pygl Gpi Gck Ugt2b1 Amy2a5 Gusb Hk2 Ugdh Pgm2l1 Ugp2 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agtr1a Ace Agt DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Cacna1a Cyp3a13 Atp1a2 Atp1a1 Atp1a3 Cyp2d22 Maoa Aox1 Cyp2c50 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Maob Chrna4 Oprm1 Cacna2d2 Htr1a TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Gclc Gclm Nagk Gnpnat1 Gfpt1 Got2 Gpt Abat Aldh4a1 Gmps Cps1 Glul Qars1 Gad1 Gss Cad Gls2 Gsr Ppat Glud1 Ears2 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Hk1 Fbp2 Aldoc Pfkm Aldob LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Cyp3a16 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cyp1a2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Mpc1 Agxt Gpt Pcx Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Map2k3 Tradd Cradd Traf2 Map2k4 Mapk8 Map2k7 Ikbkb Mapk14 Jun Ikbkg Nfkbia Map3k1 Casp2 Ripk1 Tank Nfkb1 Tnf Chuk Map2k6 Map4k2 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Pik3r6 Prkca Plcb1 Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Cpt1a Acsl1 Slc25a20 Hadh Echs1 Hadha Hadhb Acadl Cpt2 Acaa2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Itpka Inpp4a Ppip5k1 Nudt4 Ipmk Ip6k2 Impa1 Isyna1 Inpp1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Cacna1a Chrna3 Atp1a2 Atp1a1 Atp1a3 Fmo3 Aox1 Cyp2b10 Cyp2a5 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Ugt1a9 Ugt1a5 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Ppox Cox10 Flvcr2 Alad Cox15 Gusb Hmbs Ftmt Cpox Urod Alas1 Fech Uros Hmox1 Blvra GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sptlc2 Acer1 Degs2 Arsa Sgpl1 Gba1 Ugt8 Gal3st1 Acer3 Enpp7 Sphk2 Galc Ugcg Neu3 B4galt6 Sgms1 Kdsr Plpp1 Sgpp2 Glb1 Gla Sptlc1 Cerk LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Aldh2 Cndp1 Carns1 Hars2 Hal Ftcd Maoa Aldh3a1 Aoc1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Iars1 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Got2 Mdh2 Slc25a12 Slc25a11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cant1 Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cad Nme6 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Aldh7a1 Mat2a Chdh Gnmt Bhmt Dmgdh Shmt2 Shmt1 Sardh Mat2b Slc44a1 Slc44a2 Mtr PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C3 C5 Masp2 C6 C2 C4a C9 C8a Mbl2 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Fasn Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tyms Tymp Cda Slc28a1 Ces1d L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rars1 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Aldh6a1 Abat Upb1 Dpys Gad1 Aoc3 Aldh2 Cndp1 Dpyd TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Top2a Mpo Cyp3a16 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Mpc1 Me1 Pcx Pdhb Acly Slc25a11 Mdh1 Pdha1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Cyp1a2 Abcb1a Pon1 Cyp3a16 P2ry12 Cyp2c50 Cyp2b10 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacna1a Ins2 Cacnb1 Slc2a2 Cacna2d2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Gclc Gclm Nagk Gnpnat1 Gfpt1 Got2 Gpt Abat Aldh4a1 Gmps Cps1 Glul Qars1 Gad1 Gss Cad Gls2 Gsr Ppat Glud1 Ears2 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hsd17b10 Echs1 Mecr Hadha Ppt1 Hadhb Acaa2 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cant1 Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cad Nme6 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Vav3 Ms4a2 Hras Lyn Nras Lat Fcer1g Csf2 Map2k4 Lcp2 Akt1 Map2k2 Inpp5d Sos1 Tnf Map2k6 Map2k3 Plcg1 Gab2 Btk Prkca Mapk8 Map2k7 Fyn Rac1 Mapk14 Syk Il13 Pla2g4a Map2k1 Fcer1a Il4 Grb2 Il5 Mapk1 Kras Pik3ca Pik3r1 Pdk1 Raf1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi Fbp2 H6pd Prpsap1 Tktl1 Pfkm Rpe Taldo1 Pgd Rpia Dera Rbks Aldob THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Gpi Pfkp Prps2 Fbp1 Rpe Taldo1 Rpia Dera G6pdx Pgls Tktl2 Rbks Pgm1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Ikbkb Creb1 Nos3 Prkca Ikbkg Plcb1 Nfkb1 Mapk1 Mapk3 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Hlcs Acacb Spcs1 Btd LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Adsl Asl Il4i1 Nars1 Adss1 Ddo Aspa Dars1 Abat Asrgl1 Asns Ass1 Gad1 Cad ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Csad Ado Cdo1 Gad1 Ggt6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Abcc4 Nudt2 Abcc5 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Adk Dguok Rrm1 Tpmt Rrm2 Slc29a2 Ak1 Slc28a2 Gmps Gmpr Adss2 Pfas Atad1 Atic Aox1 Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Slc28a3 Slc29a1 Prps1l1 Rac1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Btg2 Hoxb9 Btg1 Ccnd1 Prmt1 Ngf Fgf1 Rb1 Trp53 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacna1a Ins2 Cacnb1 Slc2a2 Cacna2d2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Nos3 Gucy1b1 Adcy10 Trpv4 Prkg2 Prkg1 Gucy1a1 Trpc7 Kcnq5 Trpc4 Kcnq4 Kcnq3 Trpc3 Kcnq2 Gucy1a2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2d22 Cyp1a2 Cyp3a16 Cyp2c50 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Abcb1a Dck Abcg2 Slc22a1 Nme1 Slc22a2 Nt5c Pcyt2 Abcc1 Pgk1 Abcc2 Abcc4 Pcyt1a Cmpk1 Sult1a1 Slc22a3 Chpt1 Abcc3 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Cyp2d22 Abcb1a Cyp3a16 Slc6a2 Cyp2c50 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Galk1 Gck Ugdh Gale Pgm1 Galt Uxs1 Ugp2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Abcb1a Top2a Mpo Ptgs1 Ptgs2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Cyp3a16 Ugt1a1 Top2b Hspa5 Abcc3 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Gclc Gclm Nagk Gnpnat1 Gfpt1 Got2 Gpt Abat Aldh4a1 Gmps Cps1 Glul Qars1 Gad1 Gss Cad Gls2 Gsr Ppat Glud1 Ears2 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Pnp Slc2a4 Slc2a1 As3mt Gsto1 Aqp9 Aqp7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Fah Il4i1 Gstz1 Tat Yars1 Hpd Got1 Farsa Hgd Farsb HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Sars1 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Lpar2 Gng2 Gnb1 Itpr1 Plcb1 Srf Akt1 Adcy1 Rock1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Bpgm G6pc3 Pgk2 Gpi Tpi1 Pkm Pgam1 Pfkp Hk1 EG433182 Galm Slc2a13 Aldob Gapdhs PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Abcc8 Cacna1a Cacnb1 Slc2a2 Gcg Cacna2d2 Scn5a Snta1 Sntb2 Sntb1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmds Tpi1 Aldoa Hk1 Akr1b1 Fbp1 Pfkl Gmppb Phpt1 Pmm1 Fcsk Mpi Fpgt Sord Gfus Aldob Khk Pfkfb1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Crot Acsl1 Pex11g Slc25a20 Abcd2 Abcd1 Cpt2 Pex14 Crat Pex13 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Ptgir Gngt1 Myl3 Gnb1 Mylk Prkacb Adcy2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Map2k4 Myd88 Ly96 Cd14 Tirap Tlr4 Mapk8 Ecsit Tollip Irak1 Tlr1 Tlr9 Tab3 Tlr8 Tlr7 Tab2 Tab1 Tlr6 Ikbkb Tlr5 Mapk14 Tlr3 Map3k7 Tlr2 Traf6 Ikbkg Rela Nfkbia Map3k1 Nfkb1 Chuk GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Abcb1a Abcg2 Abcc1 Abcc2 Bche Pdia2 Sdf2l1 Ces2h Hyou1 Ces1d Top1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Cyp3a16 Ugt1a1 Hspa5 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi Fbp2 H6pd Prpsap1 Tktl1 Pfkm Rpe Taldo1 Pgd Rpia Dera Rbks Aldob QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Enpp1 Vnn1 Ppcs Ppcdc Coasy Pank1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Gpi Aldoa Fbp1 Rpe Taldo1 Prps1l1 Pgd Rpia Dera Pfkl G6pdx Pgls Tkt Rbks Pgm1 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ace Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Pard6a Hras Rapgef3 Rapgef2 Mapk11 Akt1 Map2k2 Pdpk1 Creb1 Gngt1 Gnb1 Prkacb Rps6ka1 Map2k6 Bad Mapk8 Elk1 Map2k7 Ikbkb Pak1 Jun Atf2 Nfkbia Arhgef7 Map3k1 Adora2a Braf Map3k4 Nfkb1 Nfkb2 Chuk Mapk1 Prkcz Pik3ca Rap1a ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mthfr Dhfr Mtfmt Aldh1l1 Mthfsl Fpgs Mthfd1 Mthfd2 Ftcd SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hsd17b10 Echs1 Mecr Hadha Ppt1 Hadhb Acaa2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Tars1 Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg1 Mpc1 Fh Idh1 Gls Slc1a3 Idh3a Dlst Pgk1 Pdhb Idh3b Aco2 Aco1 Dlat Dld Glud1 Gpi Pkm Hk2 EG433182 Pgam2 Pklr Taldo1 Mdh1 Rpia Pfkl G6pdx Slc16a1 Tkt Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Galk1 Gck Ugdh Gale Pgm1 Galt Uxs1 Ugp2 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Rpl4 Aars1 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc1 Cyp3a16 Abcc2 Abcc3 Tuba1b Trp53 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ace Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Nudt11 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq7 Coq2 Coq3 Coq5 Coq6 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Mpc1 Gpi Tpi1 Mdh2 Aldoa Hk2 Pank4 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Pck1 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Mpc1 Gpi Tpi1 Mdh2 Aldoa Hk2 Pank4 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Pck1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Agl Pygl Gpi Gck Ugt2b1 Amy2a5 Gusb Hk2 Ugdh Pgm2l1 Ugp2 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Mdh1 Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Aldh2 Cndp1 Carns1 Hars2 Hal Ftcd Maoa Aldh3a1 Aoc1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a16 Pde4d Cyp2c50 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Acadm Slc25a20 Hadh Echs1 Hadha Hadhb Acsm1 Acaa2 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult2b1 Sult1a1 Chst11 Bpnt1 Suox Papss2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Srd5a1 Hsd17b3 Akr1d1 Cyp19a1 Pdia2 Akr1c6 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp11b1 Erp29 Ugt1a1 Hspa5 Hsd11b1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Cyp2c65 Cyp3a16 Aldh1a1 Gstm2 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Egln2 Pdha1 Egln3 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Flt1 Vegfa Kdr NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Pdia2 Ugt2b36 Sdf2l1 Hyou1 Pdia6 Pdia4 Ugt1a2 Ppib Dnajb11 Ugt2b1 Oprm1 Ugt1a9 Erp29 Ugt1a1 Hspa5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi Fbp2 H6pd Prpsap1 Tktl1 Pfkm Rpe Taldo1 Pgd Rpia Dera Rbks Aldob KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cyp3a16 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Cyp1a2 Htr1a PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Chka Ptdss1 Pcyt2 Pisd Cept1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a Yars1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Bpgm G6pc3 Pgk2 Gpi Tpi1 Pkm Pgam1 Pfkp Hk1 EG433182 Galm Slc2a13 Aldob Gapdhs LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Isyna1 Vac14 Becn1 Inpp1 Pik3r4 Ippk Plcd3 Itpk1 Minpp1 Pik3c3 Fig4 Pik3ca Ambra1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hsd17b10 Ivd Ugt1a2 Acadsb Hadha Hadhb Ehhadh Acsm1 Cyp2b10 Cyp2a5 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Dars1 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1a2 Slc5a1 Atp1a1 Slc2a2 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Lct CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ace Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Scn5a Snta1 Sntb2 Sntb1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Abcc10 Cyp2d22 Ugt1a9 Cyp3a16 Aldh1a1 Cyp2b10 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Nrg2 Adam17 Prkca Egfr Erbb4 Erbb3 Psen1 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Vav3 Cdk5 Myl2 Cdkn1a Limk1 Pld1 Arfip2 Pdgfra Mylk Ralbp1 Rac1 Pak1 Pcna Map3k1 Cap1 Ccnd3 Ccnd1 Wasf1 Cfl1 Ppp1r12b Actb D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Bpgm Gpi Slc2a2 Pgam1 Aldoa Hk2 EG433182 Pgk1 Pgam2 Pfkm Galm Pklr G6pc1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sptlc2 Acer1 Degs2 Arsa Sgpl1 Gba1 Ugt8 Gal3st1 Acer3 Enpp7 Sphk2 Galc Ugcg Neu3 B4galt6 Sgms1 Kdsr Plpp1 Sgpp2 Glb1 Gla Sptlc1 Cerk GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Myd88 Fadd Tlr4 Ripk1 Tnf Tradd Tnfrsf1b Tnfrsf1a Ncoa3 Camkk2 Irak1 Il1a Il1r1 Map3k14 Tab1 Ubc Ikbkb Map3k7 Camkk1 Traf6 Ikbkg Rela Nfkbia Map3k1 Nfkb1 Chuk METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cacna1a Cyp3a13 Atp1a2 Atp1a1 Atp1a3 Cyp2d22 Cyp3a16 Cyp2c50 Cyp2b10 Cacnb1 Atp1b1 Atp1b3 Grin2a Cyp2c65 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Casp7 Gclc Oplah Gclm Gpx1 Ggt6 Gss Gsto2 Gsr Anpep KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sptlc2 Acer1 Degs2 Arsa Sgpl1 Gba1 Ugt8 Gal3st1 Acer3 Enpp7 Sphk2 Galc Ugcg Neu3 B4galt6 Sgms1 Kdsr Plpp1 Sgpp2 Glb1 Gla Sptlc1 Cerk PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Ppox Cox10 Flvcr2 Alad Cox15 Gusb Hmbs Ftmt Cpox Urod Alas1 Fech Uros Hmox1 Blvra ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Akr1d1 Hsd17b1 Cyp19a1 Sult1e1 Cyp17a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Mat2b Aldh7a1 Pemt Mat2a Mtr Chdh Ahcy Bhmt BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Hlcs Acacb Spcs1 Btd FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ace Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl4 Rps14 Cars1 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Mtor Skp2 Cdkn1b Crk Stat5a Sos1 Grb2 Jak2 Pik3r1 Trp53 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Mpc1 Agxt Gpt Pcx Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Impdh1 Abcb1a Cyp2c65 Abcg2 Ugt1a9 Cyp3a16 Abcc2 Slco1b2 Ces2h Ces1d RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat Cyp3a16 Aldh1a1 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Maoa Ddc Aldh3a1 Pnmt Aoc1 Got1 Hgd CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway Cyp1a2 Abcb1a Pon1 Cyp3a16 P2ry12 Cyp2c50 Cyp2b10 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Tpo Duox1 Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Pard6a Hras Rapgef3 Rapgef2 Mapk11 Akt1 Adcy2 Map2k2 Pdpk1 Creb1 Gngt1 Gnb1 Prkacb Rps6ka1 Map2k6 Bad Mapk8 Elk1 Map2k7 Ikbkb Pak1 Jun Atf2 Nfkbia Adora2b Arhgef7 Map3k1 Braf Map3k4 Nfkb1 Nfkb2 Chuk Mapk1 Prkcz Pik3ca Rap1a FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Bpgm Gpi Slc2a2 Pgam1 Aldoa Hk2 EG433182 Pgk1 Pgam2 Pfkm Galm Pklr G6pc1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Abcc8 Cacna1a Cacnb1 Slc2a2 Cacna2d2 Sst LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Ins2 Mtor Akt1 Irs2 Pik3cg Pik3r6 Irs1 Insr Slc7a5 Tsc2 Eif4ebp1 Tsc1 Eif4e HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Bdh1 Hmgcl Acat1 Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Sirt3 Nlrp3 Tlr4 Hif1a Il1b GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Mpc1 Gpi Tpi1 Mdh2 Aldoa Hk2 Pank4 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Pck1 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Ugt1a9 Cyp3a16 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Akr1b1 Pdhb Grhpr Pklr Dlat Mdh1 Dld Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Hagh Pcx Acyp1 Acot12 Pck1 Acat1 Pdha1 Acaca REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Cacna1a Oprk1 Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Htr4 Gngt1 Gnb1 Prkacb Ppp1ca ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Comt Hsd17b1 Sult1e1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Hras Pld1 Map3k2 Gna11 Src Fshb Lhb Gnrh1 Gnrhr Hbegf Adcy1 Camk2a Cacna1c Egr1 Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Itpr1 Plcb1 Cga Egfr Sos1 Prkcb Map2k3 Cacnb1 Prkca Mapk8 Prkaca Elk1 Map2k7 Mapk14 Cacna2d2 Jun Map3k1 Map2k1 Cacna1f Grb2 Cacna1d Mapk1 Cacna1s Raf1 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acat1 Acadvl Acaa2 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Map2k4 Eif2ak2 Ppara Myd88 Ly96 Cd14 Tirap Tlr4 Map2k6 Map2k3 Mapk8 Ecsit Tollip Irak1 Tlr9 Elk1 Tlr7 Tab2 Tab1 Ikbkb Mapk14 Tlr3 Map3k7 Tlr2 Jun Traf6 Ikbkg Fos Rela Nfkbia Map3k1 Nfkb1 Chuk CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Ptpmt1 Gpam Gpd1 Crls1 Cds2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Hras Lat Map2k4 Zap70 Cd3e Sos1 Nfatc4 Nfatc1 Prkcb Nfatc3 Nfatc2 Plcg1 Ppp3cc Prkca Mapk8 Shc1 Ptpn7 Cd3g Cd247 Elk1 Cd3d Mapk3 Ubc Pik3cg Fyn Rac1 Ppp3ca Vav1 Jun Ppp3cb Fos Rela Nfkbia Map3k1 Map2k1 Lck Nfkb1 Grb2 Rasgrp1 Pik3ca Pik3r1 Raf1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Impdh1 Hprt1 Slc28a3 Slc29a1 Abcc4 Abcc5 Xdh Adk Rac1 Tpmt Slc29a2 Slc28a2 Gmps Aox1 Ppat FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway P2ry2 Plcg1 Ptk2b Prkca Prkcb MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Il4i1 Srm Msrb2 Dnmt1 Bhmt Mtap Cbs Mars1 Cth Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cant1 Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cad Nme6 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Nos1 Ppp3ca Prkca Grin2a Prkacb Itpr1 Dlg4 Grin1 Aldh2 Xdh METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Suclg1 Mpc1 Suclg2 Fh Idh1 Gls Idh3a Dlst Pgk1 Pdhb Aco1 Dlat Dld Glud1 Gpi Pkm Pfkp Hk1 EG433182 Pgam2 Slc2a1 Taldo1 Mdh1 Pgd Rpia G6pdx Pgls Pcx Sdhd Tktl2 Sdhc Sdhb Slc16a4 Sdha Cs Dhtkd1 Pdha1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Pdxk Alpl Pdxp Pnpo Aox1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Gclc Gclm Nagk Gnpnat1 Gfpt1 Got2 Gpt Abat Aldh4a1 Gmps Cps1 Glul Qars1 Gad1 Gss Cad Gls2 Gsr Ppat Glud1 Ears2 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pip5k1a Pip4k2a Pi4ka Pikfyve Vac14 Becn1 Pik3r4 Inpp5d Inpp5e Erbb2 Synj1 Inpp4b Plcb1 Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Pik3r1 Pik3cd ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cyp2d22 Cyp3a16 Cyp2c50 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Gclc Gclm Ldha Mpst Ctns Cdo1 Cars1 Got1 Cth BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Abcc4 Slco1a4 Slc10a2 Gpbar1 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Acsl1 Slc25a20 Phyh Abcd2 Hacl1 Abcd1 Cpt2 Pex14 Crat Aldh2 Pex13 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg Serpinc1 F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Cmpk1 Cant1 Galt Slc35a2 Nme2 Slc2a1 Lalba Ugp2 B4galt1 G6pc1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Cacna1a Atp1a2 Atp1a1 Atp1a3 Cacnb1 Atp1b1 Atp1b3 Grin2a Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Cyp2c65 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Cyp3a16 Ugt1a1 Hspa5 Cyp2b10 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Akr1b1 Pdhb Grhpr Pklr Dlat Mdh1 Dld Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Hagh Pcx Acyp1 Acot12 Pck1 Acat1 Pdha1 Acaca TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Acadsb Dld Hibch Aldh6a1 Hsd17b10 Acadm Abat Bckdhb Echs1 Pcca Bcat1 Bckdha Auh Pccb Dbt Aox1 Acat1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Acads Acaa2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sptlc2 Acer1 Degs2 Arsa Sgpl1 Gba1 Ugt8 Gal3st1 Acer3 Enpp7 Sphk2 Galc Ugcg Neu3 B4galt6 Sgms1 Kdsr Plpp1 Sgpp2 Glb1 Gla Sptlc1 Cerk 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Hsd3b6 Cyp11b1 Cyp21a1 Akr1d1 Hsd3b1 Cyp11a1 Cyp11b2 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c6 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Dld Aldh2 Shmt2 Cth Shmt1 Sardh Psph Sds Sars1 Gldc Agxt Gamt Amt Maoa Gatm GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gngt1 Gnb1 Prkacb Pomc Mc2r GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Cyp2c65 Cyp3a16 Aldh1a1 Aldh3a1 Cyp2b10 Cyp2a5 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Nos1 Ppp3ca Prkca Grin2a Prkacb Dlg4 Grin1 Calm1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Hsp90aa1 Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Hras Plcg1 Prkca Mapk8 Shc1 Elk1 Map2k7 Erbb4 Mapk3 Jun Fos Stat5a Srf Map3k1 Map2k1 Rasa1 Grb2 Jak2 Egf Prkcb Stat3 Raf1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Gng2 Gnb1 Srf Akt1 Adcy1 Rock1 Lpar6 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmds Tpi1 Aldoa Hk1 Akr1b1 Fbp1 Pfkl Gmppb Phpt1 Pmm1 Fcsk Mpi Fpgt Sord Gfus Aldob Khk Pfkfb1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) P4ha3 Nos1 Ckb Asl Otc Gamt Oat Aldh4a1 Arg1 Cps1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Got1 Rars2 Glud1 Slc25a15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp46a1 Cyp27a1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Lipa Ch25h Amacr ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Casp7 Gclc Oplah Gclm Gpx1 Ggt6 Gss Gsto2 Gsr Anpep CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d22 Cyp1a2 Cyp3a16 Cyp2c50 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Hk1 Fbp2 Aldoc Pfkm Aldob PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Hars1 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Gpi Aldoa Fbp1 Rpe Taldo1 Prps1l1 Pgd Rpia Dera Pfkl G6pdx Pgls Tkt Rbks Pgm1 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d22 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a7 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhcgr Creb1 Gngt1 Gnb1 Prkacb Cga Ppp1ca Lhb Adcy2 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1a2 Slc5a1 Atp1a1 Slc2a2 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Lct FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Bpgm Mpc1 Gpi Tpi1 Slc2a2 Mdh2 Pgam1 Aldoa Hk2 EG433182 Pgam2 Slc25a11 Galm Fbp1 G6pc1 Ldha Pcx Pck1 Pgm1 Pank1 Slc37a4 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Lpl Plpp2 Gpam Gpd1 Agpat1 Akr1b1 Aldh3a1 Gpd2 Plpp1 Glyctk Lipc ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Tpi1 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Agl Pygl Gpi Gck Gys2 Amy2a5 Gusb Hk2 Sis Ugdh Ugp2 Pgm1 Pgm2l1 Mgam Gbe1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Dgat1 Lpin1 Gpam Gpd1 Agpat1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Gng2 Gnaq Gnb1 Agtr1a Ace Agt CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Aldh6a1 Abat Upb1 Dpys Gad1 Aoc3 Aldh2 Cndp1 Dpyd GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Aldh8a1 Acmsd Dlst Dhtkd1 Dld BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Wars1 Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp1 Ppip5k1 Ippk Ip6k1 Nudt3 Inpp4b Itpk1 Minpp1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg Serpinc1 F11 F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Slc25a2 Aldh7a1 Aadat Pipox Slc7a2 Aass Dlst Dld Hadh Echs1 Gcdh Dhtkd1 Acat1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Hrh1 Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Akr1d1 Hsd17b1 Cyp19a1 Sult1e1 Cyp17a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Bpgm G6pc3 Mpc1 Gpi Tpi1 Slc25a18 Mdh2 Pgam1 Pck2 Hk1 Fbp2 Pank4 EG433182 Galm Slc2a13 Cad Aldob Gapdhs KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Slc8a1 Atp1b1 Atp1b3 Atp1b2 Atp4a Atp4b Atp1a2 Atp1a1 Trpv5 Atp1a3 Slc12a3 Clcnkb Aqp3 Aqp2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Asl Otc Got2 Gpt Slc25a12 Slc1a5 Slc1a4 Arg1 Cps1 Ass1 Gls2 Glud1 Slc25a15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Ryr2 Cacna1g Cacna1h Hcn4 Cacna1c Atp1a2 Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Kcnk1 Chrm2 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Kcna5 Atp1b2 Tpm2 Prkaca Sntb2 Kcne2 Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Ms4a2 Hras Lyn Nras Lat Blnk Csf2 Akt1 Map2k2 Inpp5d Tnf Plcg1 Gab2 Prkca Mapk8 Map2k7 Fyn Rac1 Syk Il13 Map2k1 Fcer1a Lck Il4 Grb2 Mapk1 Kras Pik3r1 Raf1 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Nos3 Prkca Mapk11 Ptgs1 Mapk3 Ikbkb Creb1 Sucnr1 Ikbkg Plcb1 Nfkb1 Chuk Mapk1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp2d22 Sult1a1 Fmo1 Ugt1a9 Fmo3 Cyp3a16 Esr1 Ugt1a5 Cyp2b10 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Adcy2 Entpd8 Xdh Gart Itpa Nudt5 Dguok Rrm1 Rrm2 Ak1 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Nt5c2 Ada Hprt1 Prps1l1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Casp9 Arhgdib Jun Arhgap5 Casp1 Prf1 Apaf1 Parp1 Arhgap32 Gzmb Casp8 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Hk1 Fbp2 Aldoc Pfkm Aldob ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Casp7 Gclc Oplah Gclm Gpx1 Ggt6 Gss Gsto2 Gsr Anpep ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl4 Rps14 Rps16 Rps18 Rps15a Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Nars1 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps27 Rps9 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rpl23 Rplp1 Rpl13a FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Bpgm G6pc3 Pgk2 Gpi Tpi1 Pkm Pgam1 Pfkp Hk1 EG433182 Galm Slc2a13 Aldob Gapdhs INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Creb1 Gngt1 Gnb1 Prkacb Ppp1ca Adcy2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Msmo1 Acat2 Fdps Idi1 Hsd17b7 Mvk Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gng2 Gnb1 Itpr1 Plcb1 Lpar3 Akt1 Adcy1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Gls2 Pdha1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) ADIPOGENESIS GENES%WIKIPATHWAYS_20260910%WP447%MUS MUSCULUS Adipogenesis genes Frzb Mbnl1 Cntfr Serpine1 Gata3 Gata4 Rxrg Gata2 Cfd Nr3c1 Lpl Tgfb1 Hif1a Il6 Sp1 Dvl1 Ndn Id3 Cisd1 Pck1 Wnt1 Pck2 Fzd1 Egr2 Lif Nsg1 Rora Igf1 Bmp4 Bmp3 Stat5a Smad3 Wwtr1 Bmp2 Stat5b Bmp1 Lipe Hnf1a Hmga1 Stat6 Plin1 Plin2 Adipoq Epas1 Rara Slc2a4 Scd1 Foxo1 Creb1 Sfrp4 Nr2f1 Ppard Ppara Pparg Ptgis Rbl2 Rbl1 Klf15 Ncor1 Il6st Ncor2 Ucp1 Gadd45b Gadd45a Pnpla3 Cebpd Mef2d Cebpb Cebpa Ncoa2 Ncoa1 Zmpste24 Rb1 Fabp4 Osm Ppargc1a Lpin3 Celf1 Lpin2 Lpin1 Dlk1 Agt Mixl1 Mef2a Klf7 Klf6 Mef2b Mef2c Klf5 Lep Spock1 Stat3 E2f1 Fas Stat2 Stat1 E2f4 Srebf1 Agpat2 Gdf10 Socs1 Ins1 Gh Socs3 Irs1 Nampt Nrip1 Ins2 Irs4 Trib3 Irs2 Ahr Irs3 Ctnnb1 Lifr Tnf Prlr Bscl2 Cyp26b1 Foxc2 Wnt5b Agrp Wnt10b Twist1 Tle3 Ddit3 Nr1h3 Ebf1 Mif Retn Lmna Rxra Cyp26a1 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260910%WP544%MUS MUSCULUS Exercise induced circadian regulation Ppp1r3c Sf3a3 Nckap1 Vapa Ncoa4 Ucp3 Ugp2 Dazap2 H2bc7 Cbx3 Qki Per2 Hspa8 Per1 Klf9 Rbpms Myf6 Tab2 Tubb4a Azin1 Cebpb Psma4 Btg1 Cry1 Cry2 G0s2 Clock Herpud1 Gfra1 Pigf Erc2 Cldn5 Ppp2cb Nr1d2 Nr1d1 H2-DMa Zfr Etv6 Pura Gstp2 Idi1 Sumo1 Dnaja1 Sumo3 Eif4g2 Stbd1 Tob1 Bmal1 Gstm3 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260910%WP4265%MUS MUSCULUS Ethanol metabolism resulting in production of ROS by CYP2E1 Maff Mafg Map2k2 Mapk8 Map2k1 Cyp2e1 Prkcd Nfe2l2 Mafk Sp1 TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP113%MUS MUSCULUS TGF beta signaling pathway Serpine1 Tgfb1 Wnt1 Lif Bmp4 Mapk9 Fkbp1a Mapk3 Smad3 Tgif1 Ifng Nfkb1 Ltbp1 Jak1 Fst Tfe3 Nog Itgb6 Fos Zeb2 Zfp423 Foxh1 Thbs1 Skil Eng Lef1 Ep300 Spp1 Runx3 Runx2 Jun Tgfbr3 Egf Crebbp Smad1 Smad2 Smad4 Zfyve9 Smad9 Bambi Inhba Tgfbr1 Smad5 Tgfbr2 Smad6 Smad7 Hras Stat3 Stat1 Ctnnb1 Tnf WNT SIGNALING%WIKIPATHWAYS_20260910%WP403%MUS MUSCULUS Wnt signaling Dvl1 Wnt1 Fzd1 Prkcd Mapk9 Sfrp4 Jun Prkd1 Pafah1b1 Rhoa Wnt5a Myc Rac1 Fzd10 Wnt10a Prkcq Gsk3b Prkcg Prkch Prkci Prkcb Prkce Axin1 Ldlr Prkca Csnk1e Fbxw2 Wnt16 Wnt11 Ppp2r5c Wnt6 Wnt7b Wnt3a Dvl2 Dvl3 Wnt7a Wnt2 Prkcz Wnt4 Wnt3 Fosl1 Fzd3 Ccnd2 Fzd2 Ccnd3 Ctnnb1 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Ppp2r5e Plau Wnt10b Apc Frat1 Mapk10 MRNA PROCESSING%WIKIPATHWAYS_20260910%WP310%MUS MUSCULUS mRNA processing Rpl38 Rpl8 Rpl39 Rpl9 Rpl7 Znf830 Rpl32 Abcb4 U2surp Lsm11 Vmn1r26 Trmt2a Clp1 Rpl26 Snrpb2 Trmt1l Rpl22 Snu13 Fdx2 Raly Cfb Dcaf1 Rad21 Snrpa1 Bard1 Mettl3 Ptbp1 Cpeb1 Cpeb3 Cpeb4 Rpl39l Eif4a3 Rnpc3 Eif4a2 Mcts2 Wdr55 Scaf8 Pabpc1 Pabpc2 Nelfe Tmed10 Zfp638 Csad Srp68 Pabpc4 Pabpc5 Pabpc6 Stau1 Rbm12b1 Rbm12b2 Slbp Zfp740 Srp9 Dazl Tert Rbm8a Tut1 Nip7 Gatc Rpl19 Sf3a1 Sf3a2 Rpl11 Rpl12 Dazap1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Dnajc17 Sf3b5 Sf3b6 Akap17b Srp54 Adat1 Atxn1 Fmr1 Rnpepl1 Msi1 Msi2 Alyref2 Rbm31y Hnrnpa2b1 Supt5h Rps9 Rps7 Rnmt Snrnp70 Rps6 Ilf3 Ncl Hnrnpdl Spop Zcrb1 Virma Htatsf1 Tmem163 Oasl2 Snrnp40 Prpf18 Eftud2 Snrpf Snrpe Snrpg Snrpb Snrpa Snrpc Snrpn Alyref Ppp1r14b Ggcx G3bp1 Smn1 Elmod3 Mrpl23 Tia1 Col4a3 Fus Cnot4 Lsm2 Lsm4 Secisbp2 Lsm1 Cdk9 Son Lsm7 Lsm8 Safb2 Eral1 Synj2 Aco1 Sbno1 Hnrnpab Ilkap Mrpl11 Traf6 Rnpep Clasrp Srsf1 Ptbp3 Ptbp2 Ddx19b Srsf9 Srsf7 Ddx19a Srsf6 Srsf5 Adam5 Srsf4 Dis3 Srsf3 Srsf2 Ankar Srek1 Eif4h Tsn Eif4e Snrnp35 Hnrnpa3 Pcolce Sart3 Puf60 Wbp4 U2af1 Ppil4 Eif3g Eif3b Mrm3 Hnrnpa1 Hnrnpa0 Zfp385a U2af2 Bicc1 Cstf2t Ciz1 Ssb Celf6 Celf5 Celf4 Celf3 Celf2 Eif2d Pabpn1 Pskh1 Ro60 Sfswap Mak16 Park7 Ppm1g Dicer1 Slc25a4 Rngtt Smc1a Enox1 Enox2 Rps14 Rnps1 Ltv1 Rps11 Rps13 Rbfox1 Myef2 Rbfox2 Prpf40a Prpf40b Cirbp Uhmk1 Cdc40 Ddx39a Hnrnpll Esrp2 Pcbp2 Imp3 Pcbp1 Ddx39b Pcbp4 Esrp1 Pcbp3 Imp4 Xrn2 Alkbh8 Hnrnpr Dhx8 Dhx9 Hnrnpu Rbms1 Rbm11 Rbms3 Rbm10 Rbms2 Rbm12 Fxr1 Oas1g Fxr2 Oas1b Oas1a Dhx38 Dnd1 Elavl4 Elavl2 Adarb2 Elavl3 Elavl1 Tial1 Rps27 Rps28 Aimp1 Rps29 Rps20 Pum2 Pum3 Sugp1 Rps23 Sugp2 Pum1 Rps24 Srpk1 Zrsr2 Hnrnpc Hnrnpd Hnrnpf Hnrnpk Hnrnpl Srpk2 Hnrnpm Adad1 Cstf1 Nudt21 Prmt1 Auh Sltm Prmt2 Dhx16 Cstf2 Cstf3 Dhx15 Rsrc2 Rnasel Akap1 Slc6a8 Csde1 Rbpms2 Srsf11 Srsf12 Srsf10 Srrm1 Boll Prpf4b Slu7 Tlr5 Raver1 Nol8 Rae1 Npm1 Bclaf1 Ppargc1b Ergic2 Tardbp Znf346 Brca1 Rnaset2b Hnrnph2 Hnrnph1 Prpf4 Prpf6 Rbmxl2 Rbmxl1 Pspc1 Prpf3 Zmat4 Zmat2 Rdm1 Fbl Ppie Tarbp2 Syncrip Zbp1 Rbmx2 Matr3 Mrps28 Rbm4b Prpf8 D1Pas1 Brwd1 Papolg Ppp1r8 Nono Papolb Papola Grsf1 Nop9 Clk1 Clk2 Clk3 Clk4 Ralyl Cpsf4 Cpsf7 Srp14 Cpsf1 Cpsf2 Cpsf3 Ddx1 Tdrd7 Ddx4 Ddx5 Srp19 Ddx6 Eif4e2 Slirp Ybx1 Rbm33 Dnajc8 Dis3l2 Rbm34 Taf15 Rbm26 Rbm3 Ddx3x Rbm4 Nufip1 Rbm25 Rbm28 Sfpq Lingo1 Ddx56 Rbm7 Rbm5 Rbm6 Ewsr1 Txnl4a Adar Naa38 Rbm22 Rbm14 Rbm17 Rbm19 Oas2 Rbm18 Ankrd33b Oas3 Ddx41 Spen Nifk Polr2a Polr2g Poldip3 Eif4g3 Rpp14 Trim21 Nxf1 Rbm47 Ncbp2 Cyp4f3 Rbmy Cd2bp2 Rbmx Nxf7 Rps4x Snrpd2 Tnrc6c Snrpd1 Tra2b Acin1 Rbm42 Rbm41 Rbm43 Snrpd3 Rbm45 Rbm39 Rbm38 Ttc14 Znf622 Eif4e3 Ddx25 Naa12 Rnaseh2a Ddx24 Ddx21 Ddx20 Ttc39a Mbnl1 Ppargc1a Celf1 Eif4g2 Sf3a3 Qki Rbpms Afg3l2 Afg3l1 Phf5a Igf2bp3 Rbm15b Igf2bp1 Eif2ak2 Rpl37 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260910%WP318%MUS MUSCULUS Eicosanoid synthesis Tbxas1 Alox8 Alox5ap Pla2g2a Alox12 Alox5 Dpep1 Lta4h Alox15 Ptges Ptgds Ptges2 Ptgis Pnpla8 Ptgs1 Ggt1 Pla2g6 Ptgs2 Ltc4s OXIDATIVE STRESS AND REDOX PATHWAY%WIKIPATHWAYS_20260910%WP4466%MUS MUSCULUS Oxidative stress and redox pathway Cd44 Ggt5 Ggt7 Ggt6 Gss Idh1 Idh2 Gsr Anpep Sod3 Sod2 Sod1 Cyba Cybb Keap1 Oplah Nfe2l2 Alox5 Ptgs1 Ggt1 Ptgs2 Ncf1 Ncf2 Ncf4 Slco1a1 G6pd2 Gls Gstk1 Txnrd1 Grxcr2 Txnrd3 Txnrd2 Grxcr1 Gsto1 Mgst3 Gsto2 Mgst2 Rac1 Mgst1 Prdx2 Slc6a5 Prdx3 Gpx2 Prdx4 Gpx1 Prdx5 Gpx4 Gpx3 Slc6a9 Hpgds Gpx6 Gpx5 Prdx1 Gpx8 Gpx7 Pgd Abcc2 Abcc5 Gstp1 Gstt2 Gstt3 Gstt1 Foxp3 Lap3 Gsta3 Gsta4 Gsta1 Gsta2 Ctla4 Nrf1 Slc7a11 Txn Slco2a1 Gstm7 Gstm5 Gstm6 Ggct Gstm4 Gclc Gstm1 Gstp2 Gstm2 Cbs G6pdx Slc1a2 Slc1a5 Prdx6b Prdx6 Gclm S100a9 Gstm3 S100a8 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP539%MUS MUSCULUS Wnt signaling pathway Dvl1 Mapk1 Map3k7 Pias4 Sox1 Cdh1 Wnt1 Myb Akt1 Fzd1 Sox9 Tax1bp3 Cxxc4 Skp1 Ppp2ca Daam1 Dkk1 Magi3 Axin2 Smad3 Ror2 Crybb2 Btrc Sall1 Raf1 Cdc25c Senp2 Vangl2 Ruvbl1 Nlk Dab2 Tfap2a Jup Fzd4 Bcl9 Dlg1 Dlg2 Dlg4 Cul1 Cdk1 Pin1 Tcf4 Tcf3 Csnk2a2 Fhl2 Csnk2a1 Mark2 Ctbp1 Ctbp2 Sfrp2 Sfrp1 Csnk2b Tbp Pax2 Csnk1d Lrp1 Lrp6 Csnk1a1 Lrp5 Camk2g Nkd1 Camk2d Camk2b Camk2a Arrb2 Arrb1 Brd7 Map1b Ctnnbip1 Ankrd6 Mapk8ip1 Frat2 Hipk2 Nr5a1 Sumo1 Mapk8 Mapk9 Mapk3 Lef1 Ep300 Runx2 Jun Smad4 Rhoa Wnt5a Rac1 Gsk3b Prkcb Axin1 Prkca Csnk1e Wnt3a Dvl2 Dvl3 Wnt7a Wnt2 Wnt4 Wnt3 Fzd2 Ctnnb1 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Apc Frat1 BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260910%WP3663%MUS MUSCULUS BMP signaling pathway in eyelid development Inhbb Smad5 Foxc2 Jun Tgfa Pitx2 Fgf10 Dkk2 Smad1 Egfr Fgfr2 Smad4 Bmp4 Shh Mapk9 Map3k1 Sfrp1 Foxc1 Mapk3 Notch1 ELECTRON TRANSPORT CHAIN%WIKIPATHWAYS_20260910%WP295%MUS MUSCULUS Electron transport chain Ucp1 Sdhd Sdhc Sdhb Sdha Cox7a2l Cox6a1 Cox6a2 Uqcrfs1 Sco1 Uqcrq Coxfa4 ATP6 Atp5f1e Atp5f1d Atp5f1c mt-Atp8 Atp5mf Atp5me Cox8a Cox6b1 Ndufv2 Dmac2l Atp5mg Ndufv1 Surf1 Atp5f1b Cox15 Ndufv3 Atp5f1a Uqcrb Cox17 mt-Co2 mt-Co3 mt-Cytb Uqcrh mt-Nd4 mt-Nd5 Ucp3 mt-Nd6 Ndufab1 Ndufc1 mt-Co1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa12 Ndufa10 Cox7b Ndufs1 Slc25a27 Ndufs3 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Slc25a14 Cox6c Ndufa1 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Cox7a1 Cox7a2 Atp5po Ucp2 Cox5a Cox5b Ndufb2 Ndufb4 Uqcrc2 Ndufb3 Ndufb6 Uqcrc1 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Atp5if1 Uqcr10 Uqcr11 Slc25a5 Slc25a4 MISMATCH REPAIR%WIKIPATHWAYS_20260910%WP1257%MUS MUSCULUS Mismatch repair Pold1 Pcna Lig1 Msh2 Rfc1 Exo1 Rpa1 Mlh1 Msh6 GPCRS NON ODORANT %WIKIPATHWAYS_20260910%WP1396%MUS MUSCULUS GPCRs non odorant Fzd4 Adora2b Adora2a Ednrb Ednra Rrh Htr4 Ptgdr Trhr Htr6 Htr7 Oprd1 C3ar1 Gpr174 Galr2 Galr1 Sstr5 Avpr2 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp2 Rxfp1 Htr5b Rxfp4 Htr5a Ghrhr Tbxa2r Fpr1 Nmbr Ccr10 Vipr2 Vipr1 Ptgfr Tas2r16 Tas2r13 Agtr1a Agtr1b Tas2r137 Ccr1 Adgrb1 Lpar6 Oxtr Adgrb2 Xcr1 Adgrb3 Lpar5 Npy6r Gpr18 Grpr Gpr15 Gpr17 Tas2r140 Cckar Npbwr1 Gpbar1 Nmur2 Gnrhr Nmur1 Ntsr2 Tas2r4 Ntsr1 Ptger4 Tas2r7 Mc2r Ptger2 Gabbr1 Ptger3 Fshr Ptger1 Gabbr2 Ccr9 Ccr8 Mchr1 Ccr6 Fzd1 Crhr2 Ccr4 Crhr1 Ccr3 Ccr2 Mtnr1a Gpr132 Gipr Cckbr Mtnr1b Adgrl2 Adgrl3 Agtr2 Adgrl4 Adgrl1 Calcrl Mc1r Pth1r Rgr Taar1 Gprc5b Gpr143 Gprc5a Gcgr Kiss1r Sctr Gprc5d Mc4r Ptafr Npffr2 Pth2r Gprc6a Cysltr2 Cysltr1 Gpr6 Npsr1 Mc3r P2ry10 P2ry13 P2ry12 P2ry14 Mas1 Gpr50 F2rl1 Tas2r40 Tas2r41 F2rl2 F2rl3 Adra2a Prokr2 Ghsr Adra2c Hcar2 Prokr1 Adra2b Adgrg1 Adgrg2 Cxcr1 Cxcr2 Npy1r Cxcr3 Gpr65 Gpr68 Cxcr4 Cxcr5 Cxcr6 Adrb2 Adrb1 Adra1b Adra1a Adrb3 Adra1d Lhcgr Smo Mc5r Tacr1 Oprm1 Tacr3 Tacr2 Calcr Casr C5ar2 C5ar1 F2r Ffar3 Ffar4 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Chrm1 Hrh1 Chrm3 Chrm2 Hrh4 Chrm5 Chrm4 Hrh2 Hrh3 Drd1 Celsr3 Drd2 Drd3 Celsr1 Drd4 Drd5 Celsr2 Opn4 Opn3 Ccrl2 Gper1 Adcyap1r1 Oxgr1 Opn5 Gpr119 Adora1 Adora3 Ltb4r2 Tas2r119 Prlhr Npy5r Tmigd3 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Tas2r110 Lpar4 Ltb4r Lpar3 Lpar2 Lpar1 Npy4r Cx3cr1 Qrfpr Ptgir Htr1d Htr1f Glp1r Htr1b Htr1a Tas2r123 Adgre4 Adgre5 Adgre1 Tshr Glp2r P2ry6 P2ry4 P2ry2 P2ry1 S1pr1 Hcrtr2 Hcrtr1 S1pr3 S1pr2 S1pr5 S1pr4 Tas2r105 Ackr3 Npy2r Ackr1 Cnr1 Ackr2 Cnr2 Uts2r Ccr1l1 Oprk1 Mrgprd Tas2r103 Fzd3 Fzd2 Fzd5 Fzd7 Fzd6 Fzd9 Fzd8 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP458%MUS MUSCULUS Inflammatory response pathway Zap70 Fn1 Il2ra Il2rb Il2 Tnfrsf1b Il4 Vtn Tnfrsf1a Il5 Lamb2 Cd40lg Cd28 Lamb1 Cd86 Col1a2 Col3a1 Cd40 Col1a1 Cd80 Lama5 Il2rg Lck Il4ra Il5ra Ifng Lamc1 Lamc2 Thbs3 Thbs1 MIRNAS AND TFS IN IPS CELL GENERATION%WIKIPATHWAYS_20260910%WP2375%MUS MUSCULUS miRNAs and TFs in iPS Cell Generation Sf3a3 Prpf4 Sox2 Pou5f1 Phf5a Ddx39b Snrpa CELL CYCLE%WIKIPATHWAYS_20260910%WP190%MUS MUSCULUS Cell cycle Mcm3 Bub1b Mcm4 Mcm5 Mcm6 Cdc25b Mcm2 Cdc25a Chek1 Chek2 Orc5 Orc4 Tgfb1 Orc6 Prkdc Orc1 Orc3 Orc2 Abl1 Bub3 Cdc45 Cdh1 Mpeg1 Bub1 Cdc14b Cdc14a Plk1 Trp53 Pttg1 Cdc7 Cdc6 Mad1l1 Wee1 Smad3 Cdk6 Cdk4 Cdk2 Mdm2 E2f2 Tbc1d8 Cdc25c E2f3 Atm Cdkn1a E2f5 Cdkn1b E2f6 Atr Smc1b Ep300 Cdk1 Rbl1 Smad4 Gadd45a Pcna Rb1 Gsk3b E2f1 E2f4 Ccna1 Ccna2 Mcm7 Ccne1 Ccnd2 Ccne2 Dbf4 Ccnd3 Ywhag Hdac3 Hdac2 Hdac5 Hdac4 Hdac1 Cdkn2a Hdac7 Tfdp1 Skp2 Hdac6 Pkmyt1 Cdc20 Ccnb2 Ccnb3 Mad2l2 Ccnb1 Ccnh Espl1 Mad2l1 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP1560%MUS MUSCULUS MicroRNAs in cardiomyocyte hypertrophy Cdk9 Gata4 Tgfb1 Dvl1 Mapk1 Akt1 Fzd1 Map2k2 Mapk8 Lif Map2k1 Igf1 Mapk3 Nfkb1 Raf1 Ikbkb Pla2g2a Rcan1 Mapk7 Ikbkg Fgf2 Ikbke Plcb2 Mapk4 Pdpk1 Akt2 Nfatc4 Egf Hdac9 Edn1 Nrg1 Pik3r1 Il6st Pik3r2 Mylk3 Pik3r3 Map2k7 Mtor Map2k6 Calm1 Map2k5 Lrp6 Eif2b5 Pik3cg Lrp5 Pik3cb Pik3cd Rhoa Ppp3ca Wnt5a Camk2d Mapk14 Pik3ca Rac1 Ppp3cb Prkg1 Mylk Myef2 Map2k4 Gsk3b Map2k3 Nppb Agt Cdk7 Nppa Prkcb Rock2 Chuk Rock1 Cish Tab1 Igf1r Ctf1 Map3k14 Fgfr2 Stat3 Wnt3a Fzd2 Ctnnb1 Tnf Hdac5 Hdac4 Hdac7 NA K ATPASE SRC SIGNALING%WIKIPATHWAYS_20260910%WP5051%MUS MUSCULUS Na K ATPase Src signaling Bcar1 Pak1 Pdgfrb Pdgfra Pak6 Fyn Pak3 Pak2 Pak5 Pak4 Mapk12 Atp1b1 Casp9 Bad Cav3 Casp3 Mapk1 Cav2 Tnk2 Tesk2 Cav1 Tnk1 Ptk6 Akt1 Pten Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Styk1 Bcl2 Grb2 Mapk9 Raf1 Mapk7 Mapk4 Jun Akt2 Pik3r1 Pik3r2 Mtor Map2k6 Map2k5 Pik3cg Hras Pik3cb Pik3cd Pik3ca Rac1 Gsk3b Map2k3 Igf1r Egfr Flt1 Erbb2 Birc3 Ilk Birc2 Braf Elk1 Mapk6 Crkl Akt3 Rac2 Kdr Rac3 Rap1a Rap1b Ccnd2 Selenop Cycs Ccnd3 Ctnnb1 Cyct Xiap Ccnd1 Araf Vav1 Fgr Hck Apaf1 Pik3r5 Crk Met Sos1 Pik3r4 Blk Srms Shc3 Shc1 Atp1a1 Src Txk Dock1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260910%WP6%MUS MUSCULUS Integrin mediated cell adhesion Mapk1 Akt1 Raf1 Mapk7 Mapk4 Pdpk1 Akt2 Pik3r2 Map2k6 Map2k5 Map2k3 Rock2 Rock1 Ilk Braf Mapk6 Akt3 Rac2 Rac3 Rap1a Rap1b Selenop Araf Crk Sos1 Shc3 Shc1 Src Dock1 Bcar1 Pak1 Pak6 Fyn Pak3 Pak2 Pak4 Mapk12 Cav3 Cav2 Cav1 Map2k2 Ptk2 Map2k1 Rapgef1 Grb2 Tns1 Mylk2 Sorbs1 Tln1 Vcl Vasp Arhgef7 Pxn Itga7 Itga8 Itga5 Itga6 Itga9 Itgb6 Itga3 Itga4 Itga1 Itga2 Capn9 Itga10 Itga11 Capn5 Capn7 Capn6 Capn1 Capn3 Capn2 Itgax Itgav Itgam Itgae Itgal Vav3 Itgad Itgb8 Itgb7 Vav2 Itgb1 Itga2b Itgb4 Itgb5 Itgb2 Actn1 Hras Itgb3 Rho Csk Cdc42 Git2 Rac1 Zyx Capns1 Capn10 Capn11 Mapk10 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP450%MUS MUSCULUS IL 2 signaling pathway Fyn Nr3c1 Mapk1 Akt1 Map2k2 Mapk8 Map2k1 Bcl2 Grb2 Mapk9 Stat5a Mapk3 Eif4e Nfkb1 Stat5b Jak1 Raf1 Eif3b Creb1 Tert Pik3r1 Pik3r2 Mtor Pik3cg Pik3cb Pik3cd Mapk14 Il2ra Pik3ca Il2rb Il2 Ets1 Shb Ets2 Plcb1 Hsp90aa1 Jak3 Chuk Foxo3 Jak2 Cish Stam2 Syk Gab2 Rack1 Rela Stat3 Ifna1 Icam1 Il2rg Lck Cd53 Socs1 Ptpn6 Stat1 Itm2b Stam Socs3 Cbl Irs1 Ybx1 Crkl Rps6kb1 Ptpn11 Prkcz Kras Lyn Mapkapk2 Ptk2b Irs2 Nmi Mknk1 Vav1 Crk Sos1 Shc1 IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP93%MUS MUSCULUS IL 4 signaling pathway Fyn Bad Mapk1 Akt1 Ptk2 Prkcd Grb2 Stat5a Mapk3 Nfkb1 Jak1 Hmga1 Stat6 Ep300 Crebbp Pik3r1 Ncf1 Pik3r2 Pik3cd Mapk14 Pik3ca Il4 Ets1 Prkci Jak3 Cxcr4 Jak2 Rela Il2rg Lck Socs1 Ptpn6 Il4ra Stat1 Elk1 Stam Socs3 Cbl Irs1 Rps6kb1 Ptpn11 Prkcz Irs2 Atf2 Spi1 Prkd3 Pawr Socs5 Il13ra1 Tyk2 Bcl2l1 Plcg1 Dok2 Inpp5d Sos1 Rasa1 Grk3 Fes Mapk11 Shc1 Src FATTY ACID OXIDATION%WIKIPATHWAYS_20260910%WP2318%MUS MUSCULUS Fatty acid oxidation Acadm Cpt2 Acads Hadh Acadvl Echs1 Acaa2 Cpt1a Mttp Slc25a29 ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP435%MUS MUSCULUS One carbon metabolism Mthfd1l Mtr Ahcyl2 Dhfr Bhmt Shmt2 Dnmt3a Mtfmt Shmt1 Mat2b Gart Folh1 Ahcy Mtrr Tyms Amt Dnmt3b Mthfd1 Mthfd2 Ftcd Dnmt1 Atic Tcn2 Ehmt2 Aldh1l1 Mat1a Ehmt1 Mthfs Mthfr ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP252%MUS MUSCULUS Androgen receptor signaling pathway Cdc25b Nr3c1 Il6 Sp1 Mapk1 Prmt1 Pias4 Akt1 Trp53 Igf1 Smad3 Nr2c2 Pias3 Mdm2 Uxt Ctdp1 Raf1 Kat5 Ube2i Kat7 Gtf2f2 Gtf2f1 Pias1 Pias2 Tle5 Patz1 Flna Cdc37 Pa2g4 Brca1 Ranbp9 Senp1 Ube3a Cdk1 Rad54l2 Ar Bag1 Hmgb2 Gtf2h1 Fhl2 Psmc3ip Esr1 Esr2 Il6st Mmp1a Ncor2 Sin3a Ywhah Ghr Pou2f1 Rnf14 Calr Pou2f2 Nr0b2 Nr0b1 Ncoa2 Plagl1 Ncoa1 Spdef Etv5 Rb1 Svil Tmf1 Hspa1a Rnf4 Appl1 Ncoa3 Nsd1 Pnrc1 Cdk7 Sry Runx1 Casp8 Casp7 Casp1 Nr5a1 Stub1 Tgfb1i1 Rchy1 Ran Egfr Hipk3 Stat3 Rac3 Src Cdk9 Ncoa4 Pak6 Casp3 Cav1 Pten Map2k1 Tgif1 Pxn Cox5b Ep300 Runx2 Jun Crebbp Smad4 Slc25a4 Rela Nrip1 Ccne1 Atf2 Ctnnb1 Ccnd1 Hdac1 Ccnh BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260910%WP522%MUS MUSCULUS Biogenic amine synthesis Pnmt Hdc Asmt Gad1 Gad2 Dbh Comt Th Pah Chat Aanat Ache Tph1 Maoa Ddc MACROPHAGE MARKERS%WIKIPATHWAYS_20260910%WP2271%MUS MUSCULUS Macrophage markers Cd68 F3 Rac2 Cd86 Cd74 Cd52 Lyz2 Cd163 Cd83 Cd14 MIR 1 IN CARDIAC DEVELOPMENT%WIKIPATHWAYS_20260910%WP608%MUS MUSCULUS miR 1 in cardiac development Irx5 Hand2 Kcnd2 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260910%WP2928%MUS MUSCULUS miR 222 in exercise induced cardiac growth Hipk2 Hmbox1 Hipk1 Cdkn1b G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP298%MUS MUSCULUS G13 signaling pathway Ppp1cb Rtkn Calm1 Diaph1 Cfl1 Cfl2 Wasl Pak3 Pik3cb Rhpn2 Pik3cd Sh3rf1 Rhoa Cit Cdc42 Myl1 Pik3ca Limk1 Rac1 Mybph Pkn1 Pfn1 Pip4k2a Tnk2 Rock2 Rock1 Rps6kb1 Gna13 Mapk10 Arhgef1 Sra1 Was Arhgdib Map3k4 Pik3r2 Arhgdig Iqgap1 Iqgap2 OXYLIPINS PATHWAYS%WIKIPATHWAYS_20260910%WP5140%MUS MUSCULUS Oxylipins pathways Tbxas1 Alox8 Alox12 Fads2 Alox5 Cbr1 Dpep1 Prxl2b Lta4h Gpx1 Hpgd Alox15 Ptges Fads1 Ptgds Ephx2 Ptgis Hpgds Ggt1 Ptgs2 Ltc4s ALPHA 6 BETA 4 INTEGRIN SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP488%MUS MUSCULUS Alpha 6 beta 4 integrin signaling pathway Pak1 Rtkn Fyn Bad Casp3 Abl1 Clca1 Clca2 Akt1 Rpsa Ptk2 Ywhae Ywhab Erbin Prkcd Plec Grb2 Dsp Mmp7 Dst Cd151 Smad3 Lama1 Eif4e Lama2 Lama3 Trp73 Mst1r Ywhaz Col17a1 Eif4ebp1 Itga6 Cdkn1a Ntn1 Lamb3 Sfn Yes1 Eif6 Vim Ar Smad2 Pik3r1 Pik3r2 Ywhah Pik3r3 Mtor Itgb4 Pik3cg Pik3cb Pik3cd Rhoa Pik3ca Rac1 Lamb2 Lamb1 Prkca Egfr Erbb2 Lama5 Lamc1 Lamc2 Irs1 Irs2 Met Shc1 Src FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260910%WP3675%MUS MUSCULUS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling Mtor Itgb1 Ppargc1a Tnfrsf1a Akt1 Pten Igf1r Igf1 Ilk Smad3 Nfkb1 Irs1 Rps6kb1 Jkamp Tnf Pld1 Foxo1 Igfbp3 Igfbp2 Igfbp5 Igfbp4 Igfbp1 Pdk1 Mstn Igfbp7 Igfbp6 Tnfsf9 Smad2 Trim63 Prkab1 Acvr2b NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260910%WP431%MUS MUSCULUS Nuclear receptors in lipid metabolism and toxicity Abcd2 Cyp27b1 Abcd3 Cyp2b10 Cyp4b1 Rarb Cyp8b1 Abcb4 Rarg Vdr Nr1h4 Abcg1 Abca1 Abcc3 Cyp24a1 Abcg5 Cyp1a2 Cyp7a1 Abcb11 Cyp2e1 Abcc2 Rara Ppard Ppara Pparg Nr1h3 Nr1i3 Nr1i2 Abcb1a Cyp26a1 TRANSLATION FACTORS%WIKIPATHWAYS_20260910%WP307%MUS MUSCULUS Translation factors Eif4g3 Eif4h Eif4e Eif4a2 Pabpc1 Pabpc2 Eif4ebp1 Eif3g Eif3b Eif6 Eif2b5 Eef1a2 Eef1d Eef1a1 Eef1g Eif2ak1 Eif2ak3 Eef1b Eif1a Eif5a Paip1 Eif4b Eif3j1 Etf1 Eif3i Eif4ebp2 Eif3f Eif3e Eif4g1 Eif3h Eif4ebp3 Eif3a Eif3d Eif3c Eif2b3 Eif2b2 Eif2b4 Eif2s2 Eif2s1 Eef2k Eif2b1 Eef2 Eif1 Eif5 Eif4a1 Eif2s3x Eif2s3y Eif4g2 Eif2ak2 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260910%WP1250%MUS MUSCULUS Arachidonate epoxygenase epoxide hydrolase Cox8a Ephx2 Cox5a GPCRS PEPTIDE%WIKIPATHWAYS_20260910%WP234%MUS MUSCULUS GPCRs peptide Cckar Gnrhr Ntsr2 Ntsr1 Mc2r Npy5r Fshr Ccr9 Ccr8 Ccr6 Ccr4 Ccr3 Ccr2 Cckbr Npy4r Agtr2 Cx3cr1 Mc1r Tshr Mc4r Mc3r Npy2r Ccr1l1 Oprk1 Ghsr Ednrb Ednra Trhr Cxcr2 Npy1r Cxcr3 Oprd1 C3ar1 Cxcr4 Galr2 Cxcr5 Galr1 Cxcr6 Sstr5 Avpr2 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Lhcgr Avpr1a Mc5r Tacr1 Oprm1 Tacr3 Tacr2 Fpr1 C5ar1 Nmbr Ccr10 Bdkrb2 Bdkrb1 Agtr1a Agtr1b Ccr1 Oxtr Brs3 Fpr-s1 Oprl1 Ccr5 Galr3 Npy6r Grpr ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260910%WP2075%MUS MUSCULUS Alzheimer 39 s disease Atp2a1 Cacna1d Atp2a3 Atp2a2 Apbb1 Ide Adam17 Ryr3 Hsd17b10 Cacna1s Adam10 Lpl Nos1 Mapt Casp9 Bace1 Bad Mme Chp1 Casp3 Mapk1 Chp2 Cdk5r1 Ern1 Psenen Psen1 Fadd Psen2 Atf6 Snca Grin2a Trp53 Ncstn Aph1a Ppp3r2 Ppp3r1 Calm4 Mapk3 Calm2 Gnaq Calml3 Nae1 Bid Grin1 Casp12 Ppp3cc Cdk5 Il1b Apoe Grin2d Itpr3 Grin2c Itpr2 Grin2b Itpr1 Plcb2 Capn1 Capn2 Lrp1 Ppp3ca Ppp3cb Gsk3b Tnfrsf1a Plcb1 Casp8 Casp7 Eif2ak3 Fas Tnf Apaf1 Plcb4 App Plcb3 Cacna1f Cacna1c FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP336%MUS MUSCULUS Fatty acid biosynthesis Acacb Acaca Hadh Scd1 Pecr Mecr Pcx Ech1 Echdc3 Echdc1 Echdc2 Decr1 Acly Acss2 Acsl1 Echs1 Fasn Acaa2 Acsl5 Acsl6 Acsl3 Acsl4 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP1249%MUS MUSCULUS EPO receptor signaling Epo Epor Ptpru Pik3cg Ptprc Mapk1 Akt1 Jak2 Map2k2 Cish Map2k1 Stat3 Grb2 Stat5a Socs1 Mapk3 Stat1 Stat5b Irs1 Raf1 Irs2 Pdk1 Rasa1 Sos1 Shc1 Src G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260910%WP413%MUS MUSCULUS G1 to S cell cycle control Mcm3 Mcm4 Mcm5 Mcm6 Mcm2 Cdc25a Orc5 Orc4 Orc6 Orc1 Orc3 Orc2 Cdc45 Trp53 Wee1 Cdk6 Cdk4 Cdk2 Mdm2 E2f2 E2f3 Atm Cdkn1a E2f5 Cdkn1b E2f6 Cdk1 Rbl1 Gadd45a Pcna Mnat1 Rpa1 Tfdp2 Cdkn2b Rb1 Cdkn2c Myc Cdkn2d Prim2 Prim1 Pole2 Pola2 Ccng2 Rpa2 Cdk7 Rpa3 Cdkn1c Pole E2f1 E2f4 Ccna1 Mcm7 Ccne1 Ccnd2 Ccne2 Ccnd3 Ccnd1 Cdkn2a Tfdp1 Pkmyt1 Ccnh NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2074%MUS MUSCULUS Neural crest differentiation Dvl1 Cdh1 Wnt1 Myb Sox9 Bmp4 Axin2 Tfap2a Fgf2 Tcf4 Hdac9 Ctbp2 Neurog1 Mitf Cdh7 Cdh6 Fgf8 Cdh2 Mpz Sox5 Fgfr2 Mia Msx2 Msx3 Hoxb1 Notch1 Isl1 Foxd3 Prtg Olig3 Olig2 Olig1 Phox2b Dlx5 Gfap Tfap2b Hdac11 Hdac10 Id1 Mbp Tcf7l1 Sox10 Snai2 Snai1 Rbpj Fgfr3 Bmp7 Fgfr1 Lhx1 Lhx2 Gjb1 Tlx2 Lhx5 Fgf15 Rhob Hey2 Zic1 Nfkb2 Hdac8 Ascl1 Dmbx1 Hand1 Pax3 Notch4 Dct Pax7 Notch2 Notch3 Wnt8a Col11a2 Hoxa1 Dll1 Dll3 Dll4 Gbx2 Hes1 Hes5 Col2a1 Pmp22 Zic5 Tbx6 Nfkb1 Smad1 Itgb1 Ets1 Gsk3b Axin1 Wnt3a Dvl2 Dvl3 Fzd3 Ctnnb1 Hdac3 Hdac2 Hdac5 Hdac4 Hdac1 Hdac7 Twist1 Hdac6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260910%WP509%MUS MUSCULUS Nuclear Receptors Rarb Nr0b1 Rxrg Rarg Vdr Nr3c1 Nr5a1 Nr2e1 Hnf4a Esrra Esrrb Rora Nr2f6 Thrb Thra Nr2f2 Rorc Nr1h2 Nr2c2 Rxrb Ror1 Pgr Nr5a2 Nr4a2 Nr4a1 Rara Nr1d2 Nr2f1 Ppard Ppara Ar Pparg Nr1h3 Esr1 Esr2 Nr1i3 Nr1i2 Rxra GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260910%WP164%MUS MUSCULUS Glutathione metabolism Ggt5 Gstt2 Gstt1 Gss Idh1 Gsr Chac2 Gsta1 Anpep Gstm7 Oplah Gpx2 Dpep1 Gpx1 Ggct Gpx4 Gclc Gpx3 Gstm2 G6pdx Ggt1 Gclm HEME BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP18%MUS MUSCULUS Heme biosynthesis Ppox Alad Alas1 Alas2 Hmbs Fech Cpox Uros Urod NOVEL JUN DMP1 PATHWAY%WIKIPATHWAYS_20260910%WP3654%MUS MUSCULUS Novel Jun Dmp1 pathway Hras Rb1 Myc Ets1 Mapk1 Ets2 Map2k2 Map2k1 Trp53 E2f1 Mapk3 Braf Cdk4 Mdm2 Raf1 Kras Fos Ccnd1 Araf Arf1 Dmp1 Cdkn2a Nras Rras Jun Junb FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260910%WP33%MUS MUSCULUS Fatty acid omega oxidation Adh4 Aldh1a1 Adh1 Cyp2e1 Aldh2 Cyp1a1 Adh7 Cyp1a2 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260910%WP108%MUS MUSCULUS Selenium metabolism selenoproteins Pou2f1 Eefsec Sp3 Crem Txnrd1 Scly Sars2 Txnrd3 Selenoh Txnrd2 Selenoi Sars1 Sepsecs Selenok Fabp1 Selenom Selenon Selenoo Sp1 Dio1 Selenos Gpx2 Selenot Dio2 Gpx1 Dio3 Selenov Gpx4 Selenow Gpx3 Sephs2 Sephs1 Cth Gpx6 Trnau1ap Pstk Nfe2l2 Rela Nfkb1 Fos Selenop Jun Selenbp2 Selenbp1 Msrb1 Secisbp2 Rpl30 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260910%WP1248%MUS MUSCULUS Oxidative phosphorylation mt-Nd4 mt-Nd5 mt-Nd6 Ndufc1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa10 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufb2 Ndufb6 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Ndufa11 Coxfa4l2 Atp5mc1 Atp6ap2 Atp6ap1 Gzmb Ndufb8 Coxfa4 ATP6 Atp5f1e Atp5f1d mt-Atp8 Atp5mf Atp5me Ndufv2 Dmac2l Atp5mg Ndufv1 Atp5f1b Ndufv3 Atp5f1a ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260910%WP175%MUS MUSCULUS Acetylcholine synthesis Pcyt1a Pdha1 Pdha2 Pemt Chka Chat Ache ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260910%WP240%MUS MUSCULUS Alanine and aspartate metabolism Gad1 Gad2 Crat Adsl Got1 Got2 Gpt Abat Ass1 Carns1 Asl Aspa Agxt Dars1 Pcx BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260910%WP460%MUS MUSCULUS Blood clotting cascade F9 Serpinf2 F13b Serpine1 Serpinb2 Fgb Fga F8a1 Plau F10 Vwf F12 Fgg F11 Plat Plg F2 F5 F7 F8 LIPIDS MEASURED IN LIVER METASTASIS FROM BREAST CANCER%WIKIPATHWAYS_20260910%WP4627%MUS MUSCULUS Lipids measured in liver metastasis from breast cancer Lrat GPCRS ODORANT%WIKIPATHWAYS_20260910%WP1397%MUS MUSCULUS GPCRs odorant Adgrg5 Hcar1 Adgrg6 Gpr165 Gpr162 Adgrg7 Gpr160 Gpr161 Adgrg3 Mrgpra6 Tpra1 Tas2r39 Or5p52 Tas2r38 Gpr61 Gpr63 Mrgpra1 Or10d3 Wls Mrgpra4 Gpr176 Gpr173 Gpr171 Slc52a2 Or8g17 Vmn2r1 Or7e178 Cmklr1 Gpr179 Cmklr2 Or4c3d Or8u9 Or5g25 Or5g26 Gpr75 Or5ap2 Adgra2 Gpr183 Gpr180 Tas1r2 Or2a7 Tas1r1 Or5g9 Gpr107 Or10n1 Or10d1b Gpr101 Tas1r3 Or9s13 Or10p22 Or5p76 Or10h28 Gpr88 Gpr87 Gpr108 Gpr84 Gpr83 Or5p4 Gpr85 Tas2r135 Tas2r134 Gpr82 Or7d11 Tas2r136 Or5ar1 Or5b21 Or6b9 Gpr19 Or2b6 Or5p58 Or5p57 Or2c1 Mrgprb8 Gpr12 Mrgprb1 Tas2r143 Mrgprb2 Adgra3 Mrgprb3 Mrgprb4 Mrgprb5 Tas2r117 Tas2r116 Opn1sw Or8a1b Gpr26 Or5h19 Gpr25 Or5h17 Or5h18 Gpr27 Gpr22 Gpr21 Or5j3 Or1j1 Gpr20 Tas2r113 Or3a10 Tas2r114 Tas2r129 Or7a40 Adgrd1 Gpr139 Gpr137 Gpr135 Or5p79 Gpr37 ADGRF3 Gpr33 Taar6 Or2y1b Gpr35 Taar9 Gpr34 Taar3 Tas2r120 Or5p80 Taar2 Taar5 Gpr31 Taar4 Tas2r124 V1ra8 Tas2r125 Gpr142 Gpr141 Opn1mw Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Or1e16 Mrgprx1 Taar7e Ptgdr2 Or5t7 Or5t9 Adgrf4 Gpr153 Gpr137b Tas2r106 Adgrf5 Gpr137c Vmn1r48 Tas2r107 Gpr152 Vmn1r46 Gpr150 Vmn1r47 Gpr37l1 Adgrf1 Tas2r109 Adgrf2 Or8b8 Vmn1r45 Or5t17 Vmn1r42 Or5t15 Vmn1r43 Gpr4 Gpr3 Or8b3 Gpr157 Gpr158 Ackr5 Gpr155 Gpr156 Gphr Or5m5 Mrgprh Lgr4 Lgr5 Lgr6 Tas2r102 Or4b13 Mrgpre Tas2r104 Mrgprf Or1m1 Mrgprg Rho Brs3 Oprl1 FOCAL ADHESION%WIKIPATHWAYS_20260910%WP85%MUS MUSCULUS Focal adhesion Mapk1 Akt1 Igf1 Raf1 Flna Mapk7 Mapk4 Pdpk1 Akt2 Pik3r1 Pik3r2 Map2k6 Map2k5 Pik3cg Pik3cb Pik3cd Pik3ca Mylk Map2k3 Rock2 Rock1 Egfr Flt1 Erbb2 Birc3 Ilk Birc2 Braf Elk1 Mapk6 Crkl Akt3 Rac2 Rac3 Rap1a Rap1b Selenop Araf Vav1 Fgr Hck Pik3r5 Crk Met Sos1 Pik3r4 Blk Srms Shc3 Shc1 Rhob Src Txk Dock1 Bcar1 Pak1 Pdgfrb Diaph1 Pdgfra Pak6 Fyn Pak3 Pak2 Pak5 Pak4 Mapk12 Col11a2 Bad Cav3 Cav2 Tnk2 Tesk2 Cav1 Col2a1 Tnk1 Ptk6 Pten Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Styk1 Bcl2 Grb2 Mapk9 Mylk2 Tln1 Lama1 Vcl Lama2 Vasp Lama3 Pxn Itga7 Itga8 Itga5 Itga6 Itga9 Itgb6 Itga3 Lamb3 Itga4 Itga2 Thbs1 Itga10 Itga11 Spp1 Capn1 Jun Itgax Itgav Egf Itgam Itgae Tnc Itgal Ppp1r12a Tnn Itgad Tnr Itgb8 Tnxb Itgb7 Col5a2 Col5a3 Itgb1 Hgf Itga2b Col5a1 Itgb4 Pgf Itgb5 Actb Itgb2 Arhgap5 Actn1 Myl6 Itgb3 Reln Lama4 Rhoa Thbs2 Fn1 Cdc42 Thbs4 Pdgfc Rac1 Zyx Pdgfd Chad Pdgfa Vtn Pdgfb Gsk3b Actg1 Col4a4 Col4a1 Lamb2 Col4a2 Col4a6 Ibsp Lamb1 Parvb Col1a2 Pelo Col3a1 Col11a1 Vegfa Col1a1 Vegfd Vegfc Lama5 Vegfb Col6a2 Farp2 Lamc3 Pip5k1c Lamc1 Lamc2 Thbs3 Ccnd2 Ccnd3 Ccnd1 Vwf TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260910%WP1253%MUS MUSCULUS Type II interferon signaling IFNG Cybb Jak2 Prkcd Icam1 Stat2 Socs1 Stat1 Cxcl10 Ifng Socs3 Cxcl9 Gbp2b Ifnb1 Ptpn11 Jak1 Ifngr2 H4c14 Ifngr1 Reg1 Il1b Psmb9 Nos2 Tap1 Spi1 Ciita Irf4 Irf1 Irf2 Irf8 Isg15 Irf9 Ifit2 Eif2ak2 COMPLEMENT ACTIVATION CLASSICAL PATHWAY%WIKIPATHWAYS_20260910%WP200%MUS MUSCULUS Complement activation classical pathway C6 C7 C9 Cd55 C1qc C1qb C1qa C1ra Masp1 C8b C8a C2 C4b C3 C4a C5 C1s1 REGULATION OF PGC1A EXPRESSION BY A GSK3B TFEB SIGNALING AXIS IN SKELETAL MUSCLE%WIKIPATHWAYS_20260910%WP4763%MUS MUSCULUS Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle Tfeb Ppargc1a Gsk3b G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260910%WP232%MUS MUSCULUS G protein signaling pathways Pde7b Pde7a Adcy3 Akap7 Adcy4 Akap8 Adcy1 Akap5 Adcy2 Akap6 Adcy7 Akap3 Adcy8 Akap4 Adcy5 Adcy6 Gnaz Adcy9 Akap10 Akap11 Akap12 Prkcd Akap1 Akap9 Akap13 Pde4a Pde4b Prkaca Prkacb Gnaq Pde8a Pde8b Kcnj3 Gnai2 Gnai1 Gnai3 Ppp3cc Gna12 Gna11 Gng10 Gna15 Gna14 Prkar1a Prkar1b Gnao1 Gng3 Itpr1 Gnal Gng5 Gng4 Nras Pde4c Rras Gng7 Pde4d Gnas Gng8 Slc9a1 Gngt1 Gngt2 Prkar2a Prkar2b Pde1b Pde1c Gnb2 Pde1a Gnb1 Calm1 Gnb3 Gnb5 Gng11 Gng12 Hras Prkd1 Gng13 Rhoa Ppp3ca Prkcq Prkcg Prkch Prkci Prkcb Prkce Prkca Prkcz Kras Prkd3 Gna13 Arhgef1 Plcb3 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260910%WP1243%MUS MUSCULUS EBV LMP1 signaling Nfkb1 Ifnb1 Irak1 Pdlim7 Map3k3 Ccl20 Tradd Traf6 Ccl5 Ikbkb Traf1 Tnf Mapk1 Ikbkg Map3k7 Hsp90aa1 Chuk Mapk8 Map3k14 Rela Nfkb2 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP201%MUS MUSCULUS Ptf1a related regulatory pathway Pdx1 Hes1 Prox1 Nkx6-1 Rbpj Ptf1a Fgf10 Ctnnb1 Kat2b Rbpjl Notch1 DEREGULATION OF RENIN ANGIOTENSIN SYSTEM BY SARS COV INFECTION%WIKIPATHWAYS_20260910%WP4965%MUS MUSCULUS Deregulation of renin angiotensin system by SARS CoV infection Agtr2 Ace2 Ace Agtr1a SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260910%WP2141%MUS MUSCULUS Serotonin and anxiety Ppp3ca Fos Camk2b Htr1a Eef2 Fmr1 Grm1 Prkcb Plek Plcd4 Pomc Arc Htr2a Gabra1 Htr2c Adra1a Crh Trpv1 DELTA NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP265%MUS MUSCULUS Delta Notch signaling pathway Ascl1 Cntfr Spen Notch4 Adam17 Notch2 Notch3 Adam10 Dll1 Dll4 Mapk1 Hes1 Hes5 Psenen Psen1 Akt1 Psen2 Trp53 Skp1 Ncstn Mapk3 Smad3 Cdk2 Lef1 Ep300 Cul1 Jun Tcf3 Egf Smad1 Ncor1 Pik3r1 Smad4 Pik3r2 Ncor2 Sin3a Gsk3b Jak2 Mef2c Egfr Rela Stat3 Fhl1 Hivep3 Lck Mfng Notch1 Hey1 Numb Ccn3 Cntf Sap30 Hes6 Tle1 Maml3 Zfpm1 Numbl Fbxw7 Pofut1 Aph1b Dtx1 Hdac2 Itch Maml1 Maml2 Hdac1 Ring1 Furin Rbpj Jag2 Jag1 Skp2 Cirsr Nfkbia Magea1 Cntn1 Yy1 Snw1 Lfng App Wdr12 Hey2 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260910%WP3592%MUS MUSCULUS ApoE and miR 146 in inflammation and atherosclerosis Irak1 Apoe Rela Spi1 Traf6 Tlr4 Tlr2 Nfkb2 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260910%WP396%MUS MUSCULUS ACE inhibitor pathway Ren2 Nos3 Agt Agtr2 Kng1 Ace Bdkrb2 Ren1 Agtr1a TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260910%WP1245%MUS MUSCULUS Transcriptional activation by Nfe2l2 in response to phytochemicals Nqo1 Cebpb Aimp2 Hmox1 Ephb2 Maf Gsta2 Pik3ca Keap1 Gclc Mapk8 Prkca Nfe2l2 Gclm AMINO ACID METABOLISM%WIKIPATHWAYS_20260910%WP662%MUS MUSCULUS Amino acid metabolism Acadm Hadh Gss Idh1 Gsr Lars2 Bhmt Pdhx Tat Asns Aldh7a1 Vars1 Acss1 Bcat1 Farsb Cs Wars1 Auh Tdo2 Pck1 Suclg1 Pdk4 Hibch Sds Ftcd Arg2 Arg1 Aldh18a1 Gpt2 Cad Ehhadh Dlst Hmgcs2 Mccc1 Pkm Ldha Mars2 Sms Acaa1a Dld Mpst Oat Glud1 Pycr1 Odc1 Cps1 Prodh Adh5 Srm Rars1 Tpo Pcx Ogdh Aoc3 Fh Hmgcl Adh4 Mdh1 Aldh1a1 Mdh2 Acly Adh1 Eprs1 Iars1 Fah Adh7 Hnmt Hal G6pc2 Ppm1l P4ha2 Hibadh Gls Aco2 Mmut Glul Otc Cth Tph1 Maoa Ddc Pnmt Sdhd Hdc Pdha1 Sdha Dbh Th Gsta4 Got1 Got2 Ass1 Asl Cbs Gclm FOLIC ACID NETWORK%WIKIPATHWAYS_20260910%WP1273%MUS MUSCULUS Folic acid network Mthfr Txnrd1 Mtr Kmo Txnrd2 Cat Gsr Pnpo Xdh Selenok Fads2 Alox5 Gpx2 Gpx1 Ptges Gpx4 Selenow Ptgds Gpx3 Ptgis Cbs Gpx6 Msrb1 PURINE METABOLISM%WIKIPATHWAYS_20260910%WP2185%MUS MUSCULUS Purine metabolism Rrm2b Urad Adk Pde3a Urah Nudt16l2 Pde7b Guk1 Pde7a Pde2a Adcy3 Pgm2 Pgm1 Adcy4 Pold2 Nudt16 Adcy1 Pold4 Pold3 Adcy2 Gart Nme3 Gmps Adcy7 Prps1l3 Nme2 Adcy8 Gmpr Nme5 Adcy5 Prps1l1 Adcy6 Nme4 Fhit Adcy9 Dck Nme1 Prps1 Atic Gucy2e Gucy2d Prps2 Pde4a Gmpr2 Pde4b Gucy2c Nme7 Nme6 Pde8a Pde3b Pde8b Gucy2f Pole3 Impdh2 Pklr Polr2c Polr2d Impdh1 Polr2b Taf9 Pole4 Enpp1 Polr2h Enpp3 Polr2e Polr2f Pde5a Polr2l Polr2i Pde4c Aprt Polr2j Pde4d Polr3gl Nudt2 Hddc3 Nudt5 Polr3a Rrm1 Nudt9 Pde1b Pde11a Pde1c Rrm2 Polr3d Pde1a Polr3e Polr3b Prune1 Polr3c Pde6c Polr3h Pde6d Pde6a Polr3f Pde6b Polr3g Prim2 Pfas Prim1 Polr3k Pole2 Papss2 Pola2 Papss1 Nt5c2 Uox Pole Polr2a Polr2g Pkm Pold1 Xdh Gda Entpd1 Nt5c Entpd2 Nt5c1a Pnp Nt5e Nt5c1b Entpd5 Pde6g Entpd6 Pde6h Entpd3 Entpd4 Entpd8 Nt5m Allc Polr1b Polr1c Ak1 Polr1a Ak2 Ak5 Polr1d Ak4 Polr1e Hprt1 Ak7 Ak6 Polr1h Ak8 Adsl Cant1 Ampd3 Ampd2 Ampd1 Adcy10 Npr1 Pnp2 Pola1 Npr2 Adprm Pde9a Gucy1b1 Gucy1b2 Nt5c3a Pnpt1 Itpa Dguok Adss2 Adss1 Gucy1a2 Ppat Paics Ada Pde10a STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260910%WP216%MUS MUSCULUS Striated muscle contraction Myl1 Actg1 Tnnt3 Tnnt2 Tnnt1 Casq2 Ttn Tnnc2 Tmod1 Tnnc1 Tcap Dmd Acta1 Acta2 Jsrp1 Actc1 Tpm4 Smpx Tpm3 Tpm2 Tpm1 Neb Tnni3 Tnni2 Tnni1 Myl4 Myh1 Myom1 Des Myh3 Actn2 Vim Mybpc1 Actn3 Mybpc2 Myl2 Mybpc3 Myl3 Myh8 Actn4 Myh4 Myl9 Myom2 Myh6 Myh7 GLUTATHIONE AND ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP730%MUS MUSCULUS Glutathione and one carbon metabolism Ggt5 Gss Mtr Idh1 Ahcyl2 Gsr Bhmt Anpep Shmt2 Dnmt3a Shmt1 Mat2b Oplah Ahcy Gpx2 Mtrr Gpx1 Amt Gpx4 Dnmt3b Gpx3 Cth Dnmt1 Mat1a Mthfr Gclc Cbs G6pdx Ggt1 Chdh Gclm ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1261%MUS MUSCULUS ErbB signaling pathway Hbegf Mtor Nck1 Gab1 Cblc Nrg2 Areg Hras Btc Nrg4 Nrg3 Pak4 Myc Camk2a Bad Gsk3b Mapk1 Abl1 Tgfa Mapk8 Ptk2 Prkca Map2k1 Egfr Grb2 Erbb2 Stat5a Elk1 Akt3 Eif4ebp1 Cdkn1a Cdkn1b Araf Plcg1 Pik3r5 Crk Jun Sos1 Egf Nrg1 Shc2 Src Erbb4 Erbb3 Map2k7 Ereg OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260910%WP1274%MUS MUSCULUS Oxidation by cytochrome P450 Cyp27b1 Cyp4b1 Cyp8b1 Cyb5r4 Cyb5r3 Cyb5r2 Cyp2w1 Cyb5r1 Cyp24a1 Cyp2u1 Cyp4f3 Cyp2s1 Cyp1a2 Cyp17a1 Cyp7a1 Cyp4f39 Cyp39a1 Cyp19a1 Cyp2f2 Cyp1b1 Cyp11a1 Cyp51a1 Cyp7b1 Cyp4x1 Cyp2e1 Cyp2r1 Cyp4v3 Cyb5a Cyp26c1 Cyb5b Cyp46a1 Cyp27a1 Por Cyp11b1 Cyp21a1 Cyp20a1 Cyp11b2 Cyp26b1 Cyp1a1 Cyp26a1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260910%WP385%MUS MUSCULUS Myometrial relaxation and contraction pathways Atp2a3 Atp2a2 Ryr3 Adcy3 Adcy4 Nos1 Adcy1 Il6 Sp1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Crhr1 Pde4b Gnaq Prkacb Il1b Itpr3 Prkar1a Itpr2 Prkar1b Itpr1 Gng3 Creb1 Gng5 Gng4 Gng7 Pde4d Gnas Gng8 Gngt1 Prkar2a Prkar2b Ywhah Gnb2 Gnb1 Gnb3 Gnb5 Gng11 Gng12 Gng13 Camk2g Camk2d Camk2b Camk2a Arrb2 Arrb1 Acta1 Crh Actc1 Myl4 Myl2 Nos3 Maff Ywhae Ywhab Prkcd Mylk2 Lpar1 Nfkb1 Ywhaz Atf1 Rgs4 Rgs5 Gja1 Fos Rgs2 Sfn Ackr5 Rgs3 Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Igfbp3 Rgs7 Igfbp2 Plcg2 Igfbp5 Atf5 Igfbp4 Atf4 Igfbp1 Atf3 Jun Calm3 Pkib Calca Igfbp6 Grk5 Atf6b Grk4 Pkia Grk6 Ackr3 Pkig Cnn1 Dgkz Gnb4 Gabpb1 Rln1 Actb Ryr2 Ryr1 Prkd1 Ywhaq Oxt Adm Gsto1 Ramp1 Gabpa Guca2b Guca2a Creb3 Prkcq Cald1 Rgs20 Prkcg Actg1 Plcd1 Ets2 Prkch Rgs17 Rgs18 Prkcb Rgs19 Prkce Gng2 Rgs14 Rgs16 Prkca Cacnb3 Rgs10 Rgs11 Corin Ramp3 Ramp2 Rxfp2 Rxfp1 Prkcz Atf2 Ywhag Plcg1 Oxtr Plcb3 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260910%WP1242%MUS MUSCULUS Non homologous end joining Xrcc4 Nhej1 Mre11a Rad50 Prkdc Xrcc6 Xrcc5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP193%MUS MUSCULUS Hepatocyte growth factor receptor signaling Itgb1 Pak1 Hgf Gab1 Hras Pik3ca Mapk1 Pten Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Stat3 Grb2 Mapk3 Elk1 Pxn Crkl Map4k1 Ptpn11 Raf1 Rap1a Ptk2b Rap1b Fos Itga1 Crk Jun Met Rasa1 Sos1 Src Dock1 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2872%MUS MUSCULUS White fat cell differentiation Cebpd Cebpb Cebpa Gata3 Gata2 Nr3c1 Egr2 Klf5 Rora Nr2f2 Stat5a Ins1 Srebf1 Stat5b Mecom Ctnna1 Klf4 Klf2 Irf3 Zfp423 Rara Irf4 Tcf7l1 Foxo1 Creb1 Wnt10b Pparg Tle3 Ddit3 Nr1h3 Klf15 Ebf1 KENNEDY PATHWAY%WIKIPATHWAYS_20260910%WP1771%MUS MUSCULUS Kennedy pathway Pcyt1a Pemt Chka Sgpl1 Ptdss1 Etnk2 Ptdss2 Etnk1 Chpt1 Pisd Pcyt1b Pcyt2 Cept1 Chkb CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260910%WP553%MUS MUSCULUS Calcium regulation in cardiac cells Gjb4 Cacna1d Gjb3 Gjb6 Atp2a3 Gjb5 Atp2a2 Casq1 Atp2b2 Atp2b1 Ryr3 Atp2b3 Adcy3 Gjd2 Cacna1s Camk4 Adcy4 Atp1a4 Anxa6 Adcy1 Camk1 Kcnb1 Adcy2 Kcnj5 Pln Adcy7 Cacnb1 Atp1b3 Adcy8 Atp1b2 Adcy5 Adcy6 Gnaz Adcy9 Gnaq Prkacb Kcnj3 Gnai2 Gnai1 Gnai3 Gna11 Itpr3 Prkar1a Itpr2 Prkar1b Gnao1 Itpr1 Gng3 Gng5 Gng4 Gng7 Gnas Gng8 Gngt1 Prkar2a Prkar2b Ywhah Gnb2 Gnb1 Gnb3 Calr Gnb5 Gng11 Gng12 Gng13 Camk2g Camk2d Camk2b Camk2a Arrb2 Arrb1 Casq2 Adrb2 Adrb1 Adra1b Adra1a Adrb3 Adra1d Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Gjb1 Atp1b1 Ywhae Ywhab Prkcd Fkbp1a Ywhaz Rgs4 Rgs5 Gja1 Rgs2 Sfn Rgs3 Rgs1 Slc8a1 Rgs9 Rgs6 Rgs7 Calm3 Pkib Grk5 Grk4 Pkia Grk6 Pkig Gnb4 Ryr2 Ryr1 Prkd1 Ywhaq Prkcq Rgs20 Prkcg Prkch Rgs17 Rgs18 Prkcb Rgs19 Prkce Gng2 Rgs14 Rgs16 Prkca Cacnb3 Rgs10 Rgs11 Prkcz Ywhag Cacna1e Cacna1a Cacna1b Gja3 Gja5 Gja4 Gja8 Slc8a3 Fxyd2 Gjc1 Plcb3 Gjc2 Cacna1c Gjb2 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP407%MUS MUSCULUS Kit receptor signaling pathway Fyn Bad Mapk1 Abl1 Stap1 Grb10 Socs4 Socs6 Akt1 Matk Csf2rb Map2k1 Cltc Sh3kbp1 Cblb Grb2 Dok1 Rps6ka1 Tnfrsf10b Stat5a Kit Btk Spred1 Mpdz Stat5b Spred2 Raf1 Grb7 Grap Kitlg Plce1 Sh2b2 Tec Yes1 Ep300 Pik3r1 Pik3r2 Vav2 Epor Ptpru Pik3cg Hras Prkcb Mitf Jak2 Cish Prkca Stat3 Socs1 Ptpn6 Stat1 Cbl Crkl Ptpn11 Lyn Socs5 Vav1 Fgr Hck Plcg1 Crk Inpp5d Sos1 Rasa1 Fes Shc1 Src PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260910%WP63%MUS MUSCULUS Pentose phosphate pathway G6pdx Rpia Rpe Taldo1 Pgls Pgd Tkt PARKINSON 39 S DISEASE%WIKIPATHWAYS_20260910%WP3638%MUS MUSCULUS Parkinson 39 s disease Uba1 Park7 Ube2l6 Ube2j2 Ube2l3 Ube2j1 Mapk14 Mapk12 Casp9 Casp3 Casp7 Snca Ddc Th Ccne1 Ccne2 Cycs Atxn2 Gpr37 Pink1 Syt11 Uba7 Apaf1 Ubb Lrrk2 Htra2 Ube2g2 Ube2g1 Sncaip Eprs1 Slc6a3 Mapk11 Mapk13 Uchl1 Prkn Septin5 Casp6 Casp2 COMPREHENSIVE IL 17A SIGNALING%WIKIPATHWAYS_20260910%WP5242%MUS MUSCULUS Comprehensive IL 17A signaling Mcm3 C7 Mcm4 Mcm5 Mcm6 Mcm2 Sod2 Tgfb1 Anxa6 Il6 Orc1 Orc2 Akt1 Trp53 Igf1 Smad3 Prkacb Il1b Npm1 Mtor Mki67 Gng12 Serbp1 Sqstm1 Zmpste24 Hyou1 Cacybp Hbb-b1 Ccn2 Uggt1 Ccl5 Becn1 Mylk Cxcl12 Plch1 Cpne1 Nasp Nucks1 Rras2 Hmgb1 Arpc3 Arpc2 Arpc5 Cxcl15 Fbn1 Egfr Pik3c3 Acta1 Hbb-bh1 Stat3 Acta2 Blmh Angpt1 Tnfsf13b Gap43 Stat1 Mmp14 Mmp3 Mmp9 Upf1 Samhd1 Plaur Psmc6 Map1lc3a Map1lc3b Pon3 Atrx Hspa1b Ccl4 Ccl3 Hbb-bs Cxcl1 Snai2 Cxcl2 Snai1 Cxcl5 Ppp1r14b Rab10 Rbbp4 Tjp1 Pura Atox1 Pak3 Casp3 Bcl2 Adh1 Smad2 Ptgs2 Pcna Smad6 Smad7 Rhoa Fn1 Cdc42 Rac1 Pdgfa Pdgfb Jak2 Col1a1 Rela Mcm7 Plau C3 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP10%MUS MUSCULUS IL 9 signaling pathway Socs3 Stat5b Irs1 Ptpn11 Jak1 Kat5 Irs2 Mapk1 Tyk2 Jak3 Vcp Map2k2 Akt1 Il9 Map2k1 Il9r Shc1 Stat3 Grb2 Pik3r1 Il2rg Stat5a Mapk3 Stat1 GPCRS OTHER%WIKIPATHWAYS_20260910%WP41%MUS MUSCULUS GPCRs other Gpr165 Gpr162 Gabbr1 Fzd1 Gpr132 Or7e178 Mtnr1b Or5g26 Gpr143 Or2a7 Tas1r1 Mc4r Pth2r Or9s13 Or10p22 Cysltr1 Gpr88 Gpr84 Gpr83 Or6b9 Ghsr Or2b6 Prokr1 Adgrg1 Adrb2 Adrb1 Smo Oprm1 Tacr3 Or1j1 Calcr Casr Or7a40 Or2y1b Gpr34 Or8g20 Or1e1f Drd1 Or8c9 Celsr3 Vmn2r104 Drd2 Or1a1b Or1ad8 Celsr1 Or3a1 V1ra8 Or1e35 Drd5 Or1e34 Celsr2 Vmn1r148 Vmn1r29 Vmn1r25 Vmn1r53 Or8g19 Vmn1r54 Or4b1d Vmn1r51 Or8d1 Vmn1r52 Or8u8 Gpr146 Or1e23 Or1e16 Vmn2r107 Adora1 Or4c58 Adora3 Or51a5 Ltb4r2 Vmn1r15 Or1p1 Vmn1r13 Adgrf4 Or1x2 Tmigd3 Vmn1r14 Grm1 Vmn1r11 Or6a2 Vmn1r10 Or2z2 Vmn1r48 Or6z7 Or7a37 Or13p10 Vmn1r46 Or1a1 Or7e165 Vmn1r47 Or2n1e Gpr37l1 Or2t1 Or51a10 Or13a18 Or13a17 Or7a42 Vmn1r45 Or7a41 Or2ag2b Vmn1r42 Vmn2r32 Vmn1r65 Vmn1r43 Vmn1r62 Vmn1r63 Htr1d Gpr39 Or13a28 Or13a27 Htr1a Vmn1r58 Or2v1 Vmn1r56 Adgre5 Vmn1r50 Or3a1c Or1e17 Mrgprh Or1d2 Trhr2 Or51a39 Vmn1r49 Or2w1 S1pr1 Irx6 Vmn1r44 Vmn1r40 Vmn1r41 Or1m1 S1pr2 Or1f19 S1pr5 Or1j21 Or2a57 Vmn1r171 Vmn1r172 Ackr1 Cnr1 Oprk1 Ednra Rrh Sstr5 Ccr10 Fzd2 Vipr1 Fzd5 Fzd7 Fzd9 Xcr1 Oprl1 BDNF PATHWAY%WIKIPATHWAYS_20260910%WP2152%MUS MUSCULUS BDNF pathway Frs2 Ntrk2 Bax Serpine1 Cdc42 Rac1 Creb1 Mapk4 Trp53 Plat Bcl2 Shc1 Plg Ngfr Bdnf MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP493%MUS MUSCULUS Mapk signaling pathway Map3k13 Cdc25b Tgfb1 Mapt Mapk1 Map3k7 Akt1 Trp53 Ppp3r2 Ppp3r1 Prkaca Raf1 Ppp3cc Gna12 Il1b Nlk Ikbkb Flna Mapk7 Ikbkg Mapk4 Akt2 Mapk13 Casp6 Gadd45a Map2k7 Casp2 Map2k6 Map2k5 Ppp3ca Mapk14 Ppp3cb Hspa1a Arrb2 Arrb1 Map2k4 Casp8 Casp7 Casp1 Tab1 Mef2c Egfr Map3k14 Map3k1 Fas Braf Elk1 Mapk6 Crkl Akt3 Rac2 Rap1a Rap1b Cd14 Crk Map3k4 Pak1 Pdgfrb Pak2 Mapk12 Hspa8 Traf6 Casp9 Casp3 Tab2 Map2k2 Mapk8 Map2k1 Prkcd Grb2 Mapk9 Mapk3 Nfkb1 Nr4a1 Fos Nras Atf4 Jun Egf Bdnf Tgfbr1 Tgfbr2 Map3k8 Map3k6 Fgf4 Map3k5 Map3k20 Pla2g10 Rasgrp4 Cdc42 Myc Rasgrp1 Jund Rac1 Rasa2 Max Stmn1 Stk3 Pdgfb Prkcg Map4k4 Prkch Map4k3 Tgfb2 Prkcb Tgfb3 Fasl Nf1 Hspb1 Hspb2 Rasgrf2 Hspa5 Daxx Ppp5c Ptprr Mras Traf2 Ecsit Tmem37 Ngf Rps6ka3 Map4k1 Mink1 Prkcz Sos2 Ppm1b Kras Acvr1c Ppm1a Mapkapk2 Srf Ptpn7 Ptpn5 Atf2 Ntf4 Dusp5 Dusp4 Tnf Dusp1 Pla2g5 Acvr1b Dusp7 Dusp10 Dusp6 Taok2 Taok1 Rasa1 Gck Mapkapk5 Mapk10 Ddit3 Mos Il1a Ntrk1 Mapk8ip3 Il1r2 Il1r1 Map3k11 Map3k12 ECTODYSPLASIN A SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260910%WP3652%MUS MUSCULUS Ectodysplasin A signaling in hair follicle development Eda Sostdc1 Nfkb1 Gli1 Edaradd Relb Edar Dkk4 Ptch1 Ltb Rela Shh Dkk1 Nfkb2 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP55%MUS MUSCULUS Steroid biosynthesis F13b Hsd17b7 Hsd17b3 Hsd17b4 Hsd3b6 Hsd3b5 Hsd3b4 Cyp17a1 Hsd3b3 Hsd3b2 Hsd3b1 Hsd17b1 Hsd17b2 DYSREGULATED MIRNA TARGETING IN INSULIN PI3K AKT SIGNALING%WIKIPATHWAYS_20260910%WP3855%MUS MUSCULUS Dysregulated miRNA targeting in insulin PI3K AKT signaling Mtor Col5a3 Acaca Bad Col4a2 Flot2 Bcl2l11 Rheb Col1a2 Col3a1 Prkx Exoc7 Col1a1 Bcl2 Socs1 Mapk3 Eif4e2 Crkl Raf1 Ccnd2 Cdkn1b Sos1 Fasn Prkar2a Pik3r1 Pik3r3 ELONGATION OF VERY LONG CHAIN FATTY ACIDS%WIKIPATHWAYS_20260910%WP4491%MUS MUSCULUS Elongation of very long chain fatty acids Scd3 Scd2 Elovl6 Elovl7 Scd1 Fads2 Fads1 Scd4 Elovl2 Fasn Elovl3 Elovl4 Elovl5 Elovl1 HYPOXIA DEPENDENT SELF RENEWAL OF MYOBLASTS%WIKIPATHWAYS_20260910%WP5023%MUS MUSCULUS Hypoxia dependent self renewal of myoblasts Hey1 Myog Myod1 Hsp90b1 Pax7 Cdkn1a Myf5 Myh1 Hif1a Foxo1 Hes1 Hey2 Notch1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260910%WP2573%MUS MUSCULUS Primary focal segmental glomerulosclerosis FSGS Nck1 Fyn Tgfb1 Mme Akt1 Ptk2 Dkk1 Cd151 Tln1 Vcl Plce1 Cdkn1a Ctsl Cr1l Itga3 Cdkn1b Trpc6 Utrn Ptpro Nphs2 Vim Nphs1 Agrn Cd2ap Dag1 Krt8 Dnm1 Scarb2 Inf2 Myh9 Itgav Irf6 Podxl Myo1e Smarcal1 Wt1 Cldn1 Lmx1b Col4a5 Synpo Itgb1 Lims1 Pcna Pax2 Kirrel2 Itgb4 Kirrel3 Fat1 Lrp6 Parva Mki67 Ywhaq Itgb3 Lrp5 Camk2b Vtn Col4a4 Lamb2 Cdkn1c Cdh2 Cd80 Lama5 Ilk Notch1 Plaur Ctnnb1 Plcg1 Jag1 Actn4 Col4a3 Tlr4 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP387%MUS MUSCULUS IL 6 signaling pathway Mapt Il6 Mapk1 Map3k7 Cdk5r1 Akt1 Ppp2ca Stat5a Btk Stat5b Raf1 Hnf1a Cdk5 Nlk Tec Foxo1 Ar Pik3r1 Il6st Pik3r2 Map2k6 Cebpb Ppp2r3a Ppp2r2c Ncoa1 Ppp2r2b Ptpa Rb1 Bmx Mapk14 Ppp2r2a Ppp2r1b Ppp2r1a Foxo4 Rps6ka2 Map2k4 Sgk1 Ppp2r5d Ppp2r5b Ppp2r5a Inppl1 Eif2a Il6ra Stat3 Erbb2 Stat1 Ppp2cb Vav1 Fgr Hck Sos1 Shc1 Map3k4 Erbb3 Cdk9 Gab1 Fyn Casp9 Bad Casp3 Map2k2 Mapk8 Ptk2 Map2k1 Prkcd Grb2 Mapk3 Eif4e Nfkb1 Pxn Jak1 Eif4ebp1 Fos Ep300 Jun Crebbp Hras Rac1 Gsk3b Hsp90aa1 Foxo3 Hspb1 Jak2 Cd40 Gab2 Daxx Ppp2r5c Socs3 Rps6kb1 Ptpn11 Lyn Mapkapk2 Ptk2b Hdac1 Tyk2 Plcg1 Ppp2r5e Inpp5d Fes OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1496%MUS MUSCULUS Oxidative damage response Pcna C1qc Cdc42 Traf6 Casp9 Tnfrsf1b Traf1 Bad Map2k4 Casp3 Tnk2 Cdkn1c C3ar1 Cr2 Traf3 Map3k9 Bag4 Bak1 Bcl2 Nfkbie Tdp2 Map3k1 Traf2 Nfkb1 Cdkn1a C5ar1 Cdkn1b Cycs Cyct Tnf Apaf1 C1qb C1qa C1ra Mapk10 C2 Mapk13 C4b C5 Gadd45a C1s1 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP116%MUS MUSCULUS Hedgehog signaling pathway Igf2 Ihh Stk36 Gli1 Gli3 Gli2 Ptch2 Sap18 Sufu Ptch1 Dyrk1a Gas1 Cdk1 Crebbp Ccnb1 Shh Sin3a Rab23 Dhh Hhip Smo GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20260910%WP2852%MUS MUSCULUS Gene regulatory network modelling somitogenesis Hes1 Tbx6 Fgf8 Epha4 Mesp2 Lfng Hes7 Ripply2 Dll1 Notch1 Wnt3a GLYCOGEN METABOLISM%WIKIPATHWAYS_20260910%WP317%MUS MUSCULUS Glycogen metabolism Calm1 Ppp2r3a Ppp2r2c Ugp2 Ppp2r2b Ptpa Pgm1 Ppp2r2a Ppp2r1b Ppp2r1a Gsk3b Ppp2r5d Ppp2r5b Ppp2r5a Ppp2ca Ppp2r5c Calm2 Gbe1 Phkb Ppp2cb Gys1 Gys2 Phka1 Phka2 Ppp2r5e Gyg1 Pygb Calm3 Phkg1 Phkg2 Agl Pygl Pygm Gsk3a ESTROGEN METABOLISM%WIKIPATHWAYS_20260910%WP1264%MUS MUSCULUS Estrogen metabolism Ugt1a2 Ugt1a1 Nqo1 Comt Gsta1 Cyp1a2 Gstm1 Cyp1b1 Cyp1a1 Sult1e1 Sult1a1 Ugt1a6 Ugt1a9 IL 7 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP297%MUS MUSCULUS IL 7 signaling pathway Muc1 Bax Mcl1 Il7r Fyn Hras Rb1 Bad Gsk3b Mapk1 Jak3 Foxo3 Bcl2l11 Akt1 Map2k2 Stam2 Map2k1 Cltc Cblb Stat3 Grb2 Il2rg Stat5a Mapk3 Stat1 Cdk4 Stam Cdk2 Cbl Stat5b Irs1 Jak1 Raf1 Lyn Ccna2 Ptk2b Irs2 Ccnd2 Irf1 Foxo1 Sos1 Blk Shc1 Pik3r1 ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260910%WP1770%MUS MUSCULUS One carbon metabolism and related pathways Gss Mtr Bcat2 Dmgdh Bhmt2 Dhfr Gsr Bhmt Mat2a Shmt2 Baat Sod3 Gnmt Dnmt3a Sod2 Ahcyl1 Sod1 Shmt1 Agxt2 Sardh Cdo1 Bcat1 Tyms Mat1a Mthfr Csad Pld1 Dnm1 Gpx2 Gpx1 Gpx4 Gpx3 Cth Gpx6 Gpx5 Gpx7 Pcyt1a Gad1 Pemt Gad2 Chka Etnk2 Etnk1 Chpt1 Pcyt1b Pcyt2 Cept1 Chkb Gclc Cbs Chdh Gclm MIR302 367 PROMOTING CARDIOMYOCYTE PROLIFERATION%WIKIPATHWAYS_20260910%WP2904%MUS MUSCULUS miR302 367 promoting cardiomyocyte proliferation Mob1b Lats2 Mst1 Yap1 MIR 193A AND MVP IN COLON CANCER METASTASIS%WIKIPATHWAYS_20260910%WP3979%MUS MUSCULUS mir 193a and MVP in colon cancer metastasis Mvp G3bp1 Caprin1 Ccnd2 Myc Ccnd1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP449%MUS MUSCULUS Complement and coagulation cascades F9 C6 Serpinf2 C7 Kng1 C9 F13b Serpine1 Cd55 C1qc Cfd Cfb Serping1 Mbl1 C4bpa Masp2 Tfpi Serpina5 C8g Cd59a Cfh Cfi Klkb1 Proc Serpind1 Cd46 Thbd Pros1 Serpinc1 A2m Cpb2 Cd55b Cr1l C3ar1 Cr2 Plaur C5ar1 F2r Bdkrb1 F3 Fgb C1qb Plau C1qa F10 Vwf C1ra Masp1 F12 F11 C2 Plat C4b Plg F2 C3 F5 F7 C5 F8 C1s1 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP373%MUS MUSCULUS IL 3 signaling pathway Gata2 Chek1 Mapk1 Akt1 Bcl2l11 Matk Csf2rb Ppp2ca Stat5a Prkaca Stat5b Raf1 Stat6 Tec Rara Mapk7 Foxo1 Creb1 Dnm1 Pik3r1 Pik3r2 Pik3cd Bmx Mapk14 Pik3ca Cish Stat3 Stat1 Mmp9 Crkl Rac2 Rap1a Id1 Vav1 Hck Crk Sos1 Shc1 Gsk3a Src Pak1 Gab1 Fyn Bad Mapk8 Ptk2 Map2k1 Rapgef1 Ywhab Bcl2 Grb2 Mapk9 Mapk3 Vcl Nfkb1 Pxn Jak1 Ywhaz Atf1 Socs2 Fcer2a Gata1 Il3ra Selp Il3 Rps6kb2 Birc5 Kcnip3 Slc2a1 Mmp2 Bax Hras Cdc42 Rac1 Tnfrsf1b Gsk3b Prkcb Hspb1 Jak2 Prkca Syk Gab2 Rack1 Mras Lck Ptpn6 Socs3 Cbl Ptpn11 Kras Lyn Mapkapk2 Atf2 Spi1 Tyk2 Bcl2l1 Inpp5d Fes Rxra TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP88%MUS MUSCULUS Toll like receptor signaling Mxd3 Map2k6 Irak1 Mapk14 Traf6 Casp3 Tab2 Casp8 Chuk Fadd Traf3 Nr2c2 Nfkb1 Irf3 Ikbkb Ikbkg Ikbke Tbk1 Ticam2 Irak4 Irak3 Ticam1 Irak2 Myd88 Ralbp1 Abi1 Mal Tlr4 Eif2ak2 Tirap Tlr2 Nfkb2 Tlr3 PDGFR ALPHA AND STMN1 COOPERATE TO EXACERBATE CYTOTOXIC EFFECTS OF VINBLASTINE%WIKIPATHWAYS_20260910%WP4398%MUS MUSCULUS PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine Pdgfra Stmn1 GPCRS ORPHAN%WIKIPATHWAYS_20260910%WP1398%MUS MUSCULUS GPCRs orphan Gpr179 Gpr4 Gpr165 Gpr180 Gpr155 Gpr161 Gpr137 Gphr Tpra1 Gpr107 Gpr137b Adgrf5 Gpr137c Wls Gpr108 Slc52a2 Gpr31 Adgrf2 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP350%MUS MUSCULUS p38 Mapk signaling pathway Tgfbr1 Pla2g4a Map2k6 Hmgn1 Mef2d Ripk1 Rasgrf1 Rps6ka5 Hras Map3k5 Cdc42 Mapk14 Myc Tradd Rac1 Max Map2k4 Map3k7 Tgfb2 Hspb1 Map3k9 Daxx Grb2 Map3k1 Traf2 Stat1 Elk1 Mapkapk2 Mknk1 Atf2 Creb1 Ddit3 Shc1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260910%WP543%MUS MUSCULUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Acat1 Hmgcs2 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260910%WP2084%MUS MUSCULUS SREBF and miR33 in cholesterol and lipid homeostasis Mtor Srebf1 Ppara Ldlr Srebf2 Nr1h3 Hmgcr Ppargc1a Sirt1 Med15 Sirt6 CIRCULATING MONOCYTES AND CARDIAC MACROPHAGES IN DIASTOLIC DYSFUNCTION%WIKIPATHWAYS_20260910%WP4474%MUS MUSCULUS Circulating monocytes and cardiac macrophages in diastolic dysfunction Spp1 Ccr2 Il10 Ccl2 HYPOXIA DEPENDENT PROLIFERATION OF MYOBLASTS%WIKIPATHWAYS_20260910%WP5024%MUS MUSCULUS Hypoxia dependent proliferation of myoblasts Mtor Hgf Myog Myod1 Myf5 Fbxo32 Ddit4 Tsc2 Tsc1 Fgf1 Mstn Akt1 Rheb Calca Vegfa Smad2 Trim63 Igf1 Smad3 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260910%WP3857%MUS MUSCULUS Wnt signaling in kidney disease Csnk1a1 Lrp5 Rhoa Wnt5a Wnt10a Dvl1 Gsk3b Wnt1 Lrp4 Axin1 Wnt9b Fzd1 Mapk8 Invs Nlrp3 Wnt16 Wnt11 Mapk9 Wnt6 Wnt7b Wnt3a Dvl2 Dvl3 Wnt7a Btrc Wnt2 Wnt4 Wnt3 Kitlg Fzd3 Fzd2 Ctnnb1 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Wnt10b Apc Mapk10 SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20260910%WP2079%MUS MUSCULUS Serotonin receptor 2 and STAT3 signaling Gnaq Jak2 Htr2a Stat3 GLOBO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5305%MUS MUSCULUS Globo series sphingolipid metabolism B3galnt1 B3galt5 Fut2 Gbgt1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260910%WP3626%MUS MUSCULUS Microglia pathogen phagocytosis pathway Itgb2 C1qc Pik3cg Pik3cb Pik3cd Pik3ca Rac1 Cyba Cybb Syk Pik3c3 Tyrobp Siglec12 Ptpn6 Fcgr1 Nckap1l Pik3c2a Arpc1b Fcer1g Trem3 Rac2 Trem2 Lyn Pik3r6 Rac3 Trem1 Lat Vav1 Hck Plcg2 C1qb C1qa Itgam Vav3 Pik3r1 Ncf1 Pik3r2 Ncf2 Ncf4 Pik3r3 Vav2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260910%WP4345%MUS MUSCULUS Glycerolipids and glycerophospholipids Pnpla3 Dgkz Pcyt1a Pemt Cds1 Ptdss1 Gpat4 Pla2g1b Ptdss2 Pnpla2 Etnk1 Plpp1 Chpt1 Dgat2 Pld1 Pisd Cdipt Gpam Pcyt2 Dgat1 Agpat4 Chkb Crls1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260910%WP454%MUS MUSCULUS Osteoclast signaling Ifnb1 Itgb3 Pdgfb Spp1 Trpv5 Gpr68 Ctsk Tnfsf11 Ifnar1 Atp6v1g1 Slc9a1 Tnfrsf11b Tnfrsf11a Acp5 GPCRS SMALL LIGAND%WIKIPATHWAYS_20260910%WP353%MUS MUSCULUS GPCRs small ligand Cnr1 Lpar1 Cnr2 Ptgir Tbxa2r Ptger4 Ptgfr Ptger2 Ptgdr Ptger3 Ptger1 Ptafr S1pr1 S1pr3 S1pr2 Mtnr1a S1pr4 Mtnr1b SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20260910%WP57%MUS MUSCULUS Signal transduction of S1P receptor Sphk2 Sphk1 Mapk6 Akt3 Gnai2 Gnai1 Gnai3 Mapk12 Mapk7 Mapk1 S1pr1 Akt2 Akt1 S1pr3 S1pr2 S1pr5 Smpd2 Plcb3 Racgap1 Pik3c2g Mapk3 Asah2 GLUCURONIDATION%WIKIPATHWAYS_20260910%WP1241%MUS MUSCULUS Glucuronidation Ugt1a2 Ugt1a1 Ugt1a8 Ugt2a1 Ugt2a2 Ugt2a3 Hk1 Ugp2 Ugt1a5 Ugt2b1 Pgm2 Pgm3 Pgm1 Pgm5 Ugt2b34 Ugdh Ugt1a10 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260910%WP1270%MUS MUSCULUS Endochondral ossification Frzb Ptch1 Tgfb1 Ddr2 Chst11 Fgf18 Hmgcs1 Alpl Col10a1 Col2a1 Sox6 Adamts1 Akt1 Mmp13 Sox9 Ift88 Adamts5 Adamts4 Scin Pth Igf1 Nkx3-2 Cab39 Thra Slc38a2 Prkaca Pthlh Kif3a Serpinh1 Bmpr1a Stat5b Timp3 Bmp6 Acan Cst5 Pth1r Mgp Ctsl Enpp1 Fgf2 Spp1 Runx3 Runx2 Ghr Calm1 Tgfb2 Cdkn1c Mef2c Igf1r Vegfa Sox5 Stat1 Igf2 Ihh Mmp9 Gli3 Hdac4 Fgfr3 Bmp7 Plau Fgfr1 Plat SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260910%WP1983%MUS MUSCULUS Splicing factor NOVA regulated synaptic proteins Csn3 Aplp2 Grik2 Ncdn Efna5 Atp2b1 Camk2g Cav2 Gabbr2 Cdh2 Mapk9 Grin1 Prkcz Rap1gap Kcnma1 Clasp1 Cask Dab1 Kcnj6 Epb41l2 Grin2b Clstn1 Agrn Stxbp2 Epb41l3 Cadm3 Epb41l1 Mapk4 Cadm1 Gabrg2 Kcnq2 Stx2 Map4 Neo1 Chl1 Snw1 Plcb4 Ank3 Gphn Terf2ip Ntng1 Epb41 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4351%MUS MUSCULUS Omega 9 fatty acid synthesis Scd2 Elovl6 Acot1 Acot2 Fads2 Fads1 Acsl1 Elovl2 Fasn Elovl3 Elovl5 Acsl3 Elovl1 Acsl4 DRAVET SYNDROME SCN1A A1783V POINT MUTATION MODEL%WIKIPATHWAYS_20260910%WP5298%MUS MUSCULUS Dravet syndrome Scn1a A1783V point mutation model Gabbr1 Cacnb1 Gabbr2 Grm3 Akt1 Grin2a Nfkb1 Ldha Kcnj3 Grin1 Epb41l3 Slc2a1 Mtor Gls Glul Rasgrf1 Prr5 Rictor Fgf13 Scn1a Pik3ca Scn1b Camk2a Stxbp1 Gabra4 Ppp1r1b Gabra3 Stxbp3 Gabra2 Pcdh19 Slc2a3 Slc6a1 Slc16a7 Maob Slc16a1 Cacnb3 Slc12a5 Stx8 Gabra1 Kcna2 Gria4 Gria3 Scn2b Maoa Gria1 Chd2 Stx16 Ldhb Mlst8 Ctps2 Gad1 Cacna2d3 Gad2 Kcnj9 Kdr Scn3a Scn3b Gfap Slc1a3 Slc38a3 Slc17a7 Cacnb4 Scn4b Mapkap1 Tnf Kcnj10 Gabrb1 Gabrb3 Prr5l Cacna1a Cacna1b Slc1a2 Mapk11 EICOSANOID LIPID SYNTHESIS MAP%WIKIPATHWAYS_20260910%WP4335%MUS MUSCULUS Eicosanoid lipid synthesis map Pla2g4a Pgs1 Pla2g4b Ptges Ptgds Pla2g6 Ptgs2 Alox5 Pla2g5 BURN WOUND HEALING%WIKIPATHWAYS_20260910%WP5056%MUS MUSCULUS Burn wound healing Hbegf Lama1 Nos3 Gja1 Nos2 Tgfb1 Tnf Flii Tgfbrap1 Pecam1 Prodh2 Nlrp3 Vegfa Col1a1 Acta1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260910%WP3673%MUS MUSCULUS Hfe effect on hepcidin production Bmp6 Smad7 Tmprss6 Hjv Hfe Hamp Id1 EGFR1 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP572%MUS MUSCULUS EGFR1 signaling pathway Sp1 Mapk1 Grb10 Akt1 Snca Sh3kbp1 Cblb Rps6ka1 Stat5a Smad3 Stat5b Raf1 Grb7 Prkar1a Mapk7 Foxo1 Creb1 Krt8 Dnm1 Pik3r1 Pik3r2 Sin3a Pik3r3 Map2k7 Cebpb Map2k5 Cebpa Pik3cg Pik3cb Pik3cd Map3k3 Mapk14 Pik3ca Camk2a Stxbp1 Appl1 Rps6ka2 Map2k3 Inppl1 Egfr Map3k14 Stat3 Map3k1 Stat2 Stat1 Elk1 Crkl Araf Itch Vav1 Crk Sos1 Shc1 Sh2d3c Map3k4 Grb14 Src Elk4 Eps8 Ralb Bcar1 Krt7 Nck1 Pak1 Eps15 Gab1 Cblc Map3k2 Ap2a1 Hat1 Wasl Pitpna Rab5a Pld2 Errfi1 Usp6nl Pik3c2b Ralgds Casp9 Wnk1 Rfxank Arf4 Cav2 Hip1 Tnk2 Sh3bgrl Shoc2 Cav1 Ndufa13 H3f4 Snrpd2 Ptk6 Nck2 Asap1 Map2k2 Mapk8 Git1 Sh3gl3 Map2k1 Ywhab Epn1 Elf3 Grb2 Plec Klf11 Sh3gl2 Plscr1 Ceacam1 Mapk3 Tnip1 Tgif1 Htt Appl2 Ptpn12 Pxn Mta2 Jak1 Krt18 Krt17 Atf1 Mcf2 Reps1 Spry2 Gja1 Fos Rbbp7 Eps15l1 Reps2 Ctnnd1 Pebp1 Pkn2 Pld1 Zpr1 Plcg2 Nras Jun Egf Smad2 Vav3 Ralbp1 Abi1 Vav2 Ripk1 Rps6ka5 Hras Prkd1 Csk Cdc42 Myc Jund Rac1 Prkci Prkcb Eef1a1 Jak2 Rgs16 Prkca Gab2 Ptprr Socs1 Ptpn6 Socs3 Rps6ka3 Cbl Prkcz Sos2 Ptpn11 Kras Ptk2b Ptpn5 Dusp1 Hdac1 Plcg1 Dok2 Rasa1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260910%WP519%MUS MUSCULUS Proteasome degradation Ifng H2ax Psma3 Psma6 Uba7 Psma5 Ubb Psme3 Psma2 Psma1 Psme2 Psme1 Psmd12 Psmd11 Psmd10 Uchl1 Ube2b Psmd13 Psmb10 Uchl4 Psmb5 Uba1 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ube2d3 Ube2d1 Psma7 Psmc5 Psmc2 Rpn2 Psmc1 Psmc4 Psmc3 Rpn1 Ubc Psmb8 Psmd7 H2az1 Psmd6 Psmd9 Psmd8 Psmd3 Psmd2 Psmd5 Psmd4 Ube2d2a Hist1h2an H2-Q10 Psma4 Psmc6 Psmb9 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260910%WP723%MUS MUSCULUS Wnt signaling pathway and pluripotency Cd44 Dvl1 Map3k7 Wnt1 Fzd1 Trp53 Ppp2ca Axin2 Hnf1a Nlk Fzd4 Ppard Tcf4 Ctbp1 Ctbp2 Lrp6 Ppp2r2c Lrp5 Ppp2r2b Ptpa Nkd1 Ppp2r2a Ppp2r1b Ppp2r1a Foxd3 Tcf7l1 Ppp2cb Prkcd Mapk9 Mmp7 Ctnnd1 Lef1 Ep300 Jun Crebbp Prkd1 Pafah1b1 Rhoa Wnt5a Myc Wnt10a Prkcq Gsk3b Prkcg Prkch Prkci Prkcb Prkce Axin1 Ldlr Wnt9b Prkca Csnk1e Fbxw2 Wnt16 Wnt11 Ppp2r5c Wnt6 Wnt7b Ppp2r2d Wnt3a Dvl2 Nanog Dvl3 Hnf1b Zbtb33 Wnt7a Wnt2 Nfya Sox2 Prkcz Nkd2 Wnt4 Pou5f1 Ppm1j Wnt3 Fosl1 Fzd3 Ccnd2 Fzd2 Ccnd3 Ctnnb1 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Ppp2r5e Plau Wnt10b Apc Frat1 Mapk10 Racgap1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260910%WP166%MUS MUSCULUS Apoptosis modulation by HSP70 Nfkb1 Ripk1 Bid Aifm1 Hspa1a Casp9 Casp3 Tnfrsf1a Apaf1 Casp8 Casp7 Fadd Mapk10 Map3k1 Fas Casp6 Casp2 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260910%WP1258%MUS MUSCULUS Homologous recombination Pold1 Mre11a Rpa1 Atm Rad51 Rad52 Brca2 Pold2 Nbn Rad54b Pold4 Pold3 Rad50 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260910%WP4347%MUS MUSCULUS Eicosanoid metabolism via cyclooxygenases COX Pla2g4a Ptgdr2 Ptgdr Cyp4f3 Prxl2b Hpgd Ehhadh Ptgir Acaa1a Tbxa2r Tbxas1 Cyp4a12a Ptgfr Cyp4f14 Cyp4a12b Pla2g5 Cyp4a10 Akr1b1 Ptgr2 Ptgr1 Pla2g4b Acox1 Ppard Ptges Ptgds Acox2 Acox3 Ptgis Ptgs1 Pla2g6 Ptgs2 HEART DEVELOPMENT%WIKIPATHWAYS_20260910%WP2067%MUS MUSCULUS Heart development Tbx5 Foxa2 Tbx2 Hand1 Bmpr2 Gata6 Gata4 Mapk1 Pitx2 Mef2c Fgf10 Fgf8 Vegfa Vegfc Shh Vegfb Bmp4 Foxc1 Notch1 Hey1 Isl1 Bmp2 Bmpr1a Ptpn11 Srf Ctnnb1 Foxh1 Foxc2 Hand2 Tbx10 Smyd1 Nfatc4 Nkx2-5 Bhlhe40 Smad1 Bmp10 Nfatc1 Smad4 Nfatc3 Hey2 Nfatc2 Erbb3 Tbx20 Irx4 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260910%WP1272%MUS MUSCULUS Selenium micronutrient network mt-Co2 Mthfr Mtr Kmo Cat Gsr Pnpo Xdh mt-Co1 Selenok Tbxas1 Selenop Fads2 Alox5 Gpx2 Gpx1 Ptges Fads1 Gpx4 Ptgds Gpx3 Ptgis Gpx6 MECHANISMS ASSOCIATED WITH PLURIPOTENCY%WIKIPATHWAYS_20260910%WP1763%MUS MUSCULUS Mechanisms associated with pluripotency Cd44 Tfeb Mapk1 Pias4 Cdh1 Psen1 Akt1 Trp53 Dkk1 Prkaca Cdk2 Mdm2 Sall1 Raf1 Cdkn1a Tfap2a Pin1 Dazl Tert Ctbp1 Ctbp2 Mtor Lrp5 Pik3cd Nkd1 Nppb Rock2 Mitf Rock1 Shh Ncl Notch1 Inhbb Foxd3 Atrx Id1 Tcf7l1 Hck Rbpj Rbbp4 Fgfr1 Sos1 Yy1 Casp3 Gbx2 Pten Esrrb Grb2 Nr2f6 Cad Nr2f2 Mta2 Nr5a2 Rbbp7 Tpo Rras Itgb1 Sp3 Fgf4 Rela Icam1 Ins1 Nanog Irs1 Dhx9 Ptpn11 Hnrnpu Acvr1c Atf2 Ctnnb1 Lifr Npr1 Acvr1b Twist1 Bmpr2 Gata6 Znf281 Relb Rcor2 Thap11 Cer1 Sf1 Skic8 Dnmt3a Tcl1 Tgfb1 Uhrf1 Hif1a Nobox Hcfc1 Sp1 Insr Dvl1 Zmym2 Znf143 Nme2 Kdm6b Lefty1 Cabin1 Dnmt3b Bcam Ocln Fzd1 T T2 Lif Dnmt1 Dnmt3l Phc1 Ehmt2 Nodal Gdf9 Bmp4 Rel Ehmt1 Ctr9 Paf1 Smad3 Gatad2a Gatad2b Cubn Ezh2 Ezh1 Kat5 Terf2 Myod1 Ep400 Ube2i Ddb1 Ptprs Hells Suz12 Pbrm1 Pias2 Ctcf Tle5 Xpo4 Parp1 Med12 Tet1 Brca1 Creb1 Zfx Acvr1 Nr2f1 Rtn4r Mtf2 Lyar H3-3b Stk40 Rbl2 Rybp Leo1 Mbd3 Il6st Dpysl2 Cdx2 Mbd2 Sin3a Satb2 Satb1 Gadd45a Pou2f1 Elp4 Wwp2 Mef2d Zscan10 Dffa Nr2c1 Rif1 Nr0b1 Ncoa1 Zfp42 Mpl Ipo7 Etv5 Kpnb1 Fgf5 Mycn Ppp2r1a Ipo9 Pim1 Dgka Grsf1 Sgk1 Pim3 Tle4 Tle2 Fbxo15 Kdm1a Usp7 Hira Perp Mef2c Sall4 Sall3 Klf5 Tcf7 Jarid2 Stat3 Tfap2c Niban1 Nedd4l Tfcp2l1 Smo Jade1 Otx2 Plet1 Zfp57 Nacc1 Kpna2 Kmt2d P4ha1 Ogt Cdc73 Kdm4c Cers2 Zic2 Zic3 Gadd45gip1 Cdk2ap1 Eras Utf1 Eed Mybl2 Hand2 Kdm5c Kdm6a Rcn2 Ewsr1 Chd4 Smarca2 Smarca4 Sumo1 Smarca5 Dppa4 Trim28 Trim24 Epop Rnf2 Rest Zfp219 Mta1 Gab1 Smarcad1 Arid3b Ercc5 Trim33 Kdm3a Tbx3 Pml Ssrp1 Smarcc1 Map2k1 Mapk3 Nfkb1 Jak1 Tfe3 Fos Socs2 Lef1 Igfbp3 Ep300 Spp1 Crebbp Smad1 Smad2 Smad4 Tgfbr1 Smad7 Hras Wnt5a Myc Gsk3b Prkcg Axin1 Wnt3a Sox2 Pou5f1 Klf4 Klf2 Ccnd1 Hdac2 Hdac4 Hdac1 Cdkn2a Apc GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260910%WP456%MUS MUSCULUS GPCRs class B secretin like Adgrl2 Adgrl3 Adgrl4 Adgrl1 Calcr Ghrhr Calcrl Adcyap1r1 Pth1r Glp1r Vipr2 Vipr1 Adgre5 Gcgr Adgrg2 Adgre1 Sctr Glp2r Pth2r Crhr2 Crhr1 Gipr MONOAMINE GPCRS%WIKIPATHWAYS_20260910%WP570%MUS MUSCULUS Monoamine GPCRs Drd5 Adra2a Adra2c Adra2b Htr4 Htr6 Htr7 Adrb2 Htr2a Adrb1 Htr2c Adra1b Htr2b Adra1a Adrb3 Adra1d Htr5b Htr5a Htr1d Htr1f Htr1b Htr1a Chrm1 Hrh1 Chrm3 Chrm2 Chrm5 Chrm4 Hrh2 Drd1 Drd2 Drd3 Drd4 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260910%WP1498%MUS MUSCULUS Dopaminergic neurogenesis Ascl1 Foxa2 Gli1 Ret Tgfb1 Neurog2 En2 En1 Nkx2-2 Gbx2 Slc18a2 Msx1 Nkx6-1 Lmx1a Cdkn1c Neurod1 Wnt1 Pitx3 Fgf8 Stat3 Shh Ddc Otx2 Gli2 Sox2 Nr4a2 Th Aldh1a1 Slc6a3 Lmx1b MIR 127 IN MESENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP3991%MUS MUSCULUS miR 127 in mesendoderm differentiation Foxa2 Acvr1 Acvr2a Cfc1 T Lefty2 T2 Smad2 Nodal Smad4 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260910%WP238%MUS MUSCULUS Osteoblast signaling Pdgfrb Pdgfra Tnfsf11 Pth1r Bglap2 Tnfrsf11b Slc17a2 Col1a1 Fgf23 Pth PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260910%WP4835%MUS MUSCULUS Peroxiredoxin 2 induced ovarian failure Hsd3b3 Bax Cyp11a1 Star Cycs Prdx2 Casp3 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260910%WP1252%MUS MUSCULUS Amino acid conjugation of benzoic acid Acss2 Glyat CHOLESTEROL BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP103%MUS MUSCULUS Cholesterol biosynthesis Dhcr7 Fdft1 Lss Sqle Pmvk Sc5d Mvd Msmo1 Hmgcr Hmgcs1 Idi1 Cyp51a1 Fdps Nsdhl Mvk NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1256%MUS MUSCULUS Nod like receptor NLR signaling pathway Ikbkg Map3k7 Chuk Ephb2 Mapk8 Cd40 Erbin Rela Ikbkb DISTAL CONVOLUTED TUBULE 1 DCT1 CELL%WIKIPATHWAYS_20260910%WP4183%MUS MUSCULUS Distal convoluted tubule 1 DCT1 cell Stk39 Slc12a3 Wnk4 Kcnj16 Clcnkb Wnk1 Cab39 B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP274%MUS MUSCULUS B cell receptor signaling pathway Hnrnpk Mapk1 Map3k7 Stap1 Akt1 Bcl2l11 Cblb Dok1 Rel Rps6ka1 Ppp3r1 Cdk6 Btk Cdk4 Cdk2 Raf1 Sh2b2 Tec Itpr2 Ikbkb Itpr1 Foxo1 Ikbkg Creb1 Mapk4 Pdpk1 Pik3r1 Pik3r2 Pik3cg Ptprc Ppp3ca Rb1 Mapk14 Ppp3cb Cdk7 Casp7 Chuk Arpc3 Arpc2 Cr2 Arpc5 Stat3 Rps6 Stat1 Braf Elk1 Crkl Vav1 Hck Crk Nfkbia Sos1 Blk Was Shc1 Gsk3a Bcar1 Nck1 Gab1 Fyn Casp9 Pip4k2a Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Prkcd Bcl2 Grb2 Mapk3 Cd72 Sla2 Chst15 Pdk2 Cd81 Plcg2 Gtf2i Actr2 Actr3 Dok3 Jun Rasgrp3 Pip4k2b Pip4k2c Cd79a Cd79b Bcl10 Pik3ap1 Bcl6 Cd19 Arpc4 Vav2 Itk Rap2a Dapp1 Bax Bank1 Cd22 Atp2b4 Prkd1 Plekha2 Plekha1 Zap70 Rhoa Hcls1 Csk Card11 Lat2 Blnk Lime1 Lcp2 Prkcq Ptpn18 Gsk3b Cd5 Fcgr2b Sh3bp2 Cmtm3 Prkcb Nedd9 Prkce Pip5k1b Pip5k1a Syk Gab2 Rela Lck Ptpn6 Pip5k1c Arpc1b Cbl Rps6kb1 Map4k1 Sos2 Ptpn11 Lyn Ccna2 Mapkapk2 Ptk2b Ccne1 Ccnd2 Atf2 Ccnd3 Ctnnb1 Dusp4 Hdac5 Plcg1 Hdac7 Dusp6 Inpp5d Rasa1 Nfatc1 Nfatc3 Nfatc2 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260910%WP3625%MUS MUSCULUS Tyrobp causal network in microglia C1qc Maf Rbm47 Rps6ka1 Stat5a Rgs1 Spp1 Runx3 Itgax Itgam Ncf2 Tgfbr1 Itgb2 Hcls1 Tnfrsf1b Gpx1 Adap2 Plek Il18 Sft2d2 Cytl1 Tmem106a Lyl1 Dpyd Cd84 Tyrobp Kcne3 Abcc4 Nckap1l Bin2 Npc2 Elf4 Lhfpl2 Cd37 Samsn1 Creb3l2 Ppp1r18 Il10ra Zfp36l2 Apbb1ip Cd4 Fkbp15 Hlx Rnase6 Tcirg1 Il13ra1 Loxl3 Gapt Slc7a7 Pycard Capg Sh2b3 Igsf6 Nrros Gal3st4 Cxcl16 Slc1a5 C3 INSULIN SIGNALING%WIKIPATHWAYS_20260910%WP65%MUS MUSCULUS Insulin signaling Map4k5 Map3k13 Rab4a Egr1 Xbp1 Tbc1d4 Ehd1 Map4k2 Ehd2 Snap25 Snap23 Rhoj Ptprf Rhoq Cap1 Rrad Insr Inpp4a Mapk1 Vamp2 Map3k7 Rps6ka4 Rps6ka6 Sgk3 Grb10 Sgk2 Flot2 Arf6 Akt1 Myo1c Rheb Ptpn1 Pfkl Stx4 Arhgap33 Cblb Pfkm Ppp1cc Rps6ka1 Map3k10 Kif3a Raf1 Lipe Sh2b2 Enpp1 Ikbkb Slc2a4 Mapk7 Foxo1 Stxbp2 Mapk4 Pdpk1 Akt2 Mapk13 Pik3r1 Pik3r2 Pik3r3 Map2k7 Mtor Map2k6 Map2k5 Pik3cg Pik3cb Pik3cd Map3k3 Mapk14 Pik3ca Stxbp1 Rps6ka2 Map2k4 Sgk1 Map2k3 Stxbp3 Inppl1 Map3k9 Igf1r Pik3c3 Map3k14 Map3k1 Elk1 Mapk6 Rac2 Gys1 Gys2 Gyg1 Crk Sos1 Pik3r4 Shc3 Shc1 Map3k4 Shc2 Grb14 Gab1 Cblc Map3k2 Mapk12 Pten Map2k2 Mapk8 Map2k1 Rapgef1 Prkcd Grb2 Mapk9 Sorbs1 Mapk3 Eif4e Eif4ebp1 Fos Rps6kb2 Arf1 Slc2a1 Jun Map3k8 Map3k6 Rps6ka5 Hras Map3k5 Rac1 Prkcq Gsk3b Map4k4 Prkch Map4k3 Tsc2 Prkci Tsc1 Prkcb Foxo3 Prkca Socs1 Pik3c2a Socs3 Rps6ka3 Cbl Irs1 Rps6kb1 Map4k1 Mink1 Prkcz Sos2 Ptpn11 Irs4 Trib3 Srf Irs3 Mapk10 Mapk11 Cyth3 Stxbp4 Prkaa1 Prkaa2 Kif5b Pik3c2g Map3k11 Flot1 Map3k12 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260910%WP4346%MUS MUSCULUS Cholesterol metabolism with Bloch and Kandutsch Russell pathways Hsd17b7 Fads2 Hmgcs1 Fads1 Cyp51a1 Elovl2 Elovl3 Fdps Elovl4 Ch25h Elovl5 Nsdhl Ggps1 Hmgcs2 Mvk Cyp46a1 Lbr Nr1h2 Dhcr7 Cyp27a1 Fdft1 Scd2 Acat2 Soat2 Lss Soat1 Sqle Tm7sf2 Pmvk Sc5d Mylip Mvd Idi2 Msmo1 Ebp Dhcr24 Scd1 Acsl1 Fasn Acsl3 Acsl4 Acot1 Acot2 Acat1 Srebf2 Abcg1 Hmgcr Abca1 Cyp7a1 Srebf1 Idi1 Nr1h3 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260910%WP4344%MUS MUSCULUS Sphingolipid metabolism overview Sphk2 Sphk1 Sgpl1 Smpd1 Cers6 Cers2 Plpp3 Cers4 Cers3 Plpp1 Asah1 Cers1 Sgms1 Sgms2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Degs1 Gdf1 Kdsr Sgpp2 Ugcg Sgpp1 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260910%WP374%MUS MUSCULUS Prostaglandin synthesis and regulation Scgb1a1 Pla2g4a Hsd11b1 Hsd11b2 Anxa5 Anxa4 Anxa3 Anxa2 Anxa1 S100a10 Ptger4 Ednrb Ednra Anxa6 Ptger2 Ptgdr Ptger3 Ptger1 Hpgd Cyp11a1 Ptgir Tbxas1 Ptgfr Ptgds Ptgis Ptgs1 Edn1 Ptgs2 Anxa8 Prl S100a6 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260910%WP1251%MUS MUSCULUS Metapathway biotransformation Ugt2a2 Gss Ugt2a3 Ugt1a5 Gsr Ugt1a10 Chst11 Chst10 Akr7a2 Chst12 Chst13 Chst14 Naa80 Ndst1 Ndst2 Sult1c2 Ndst3 Ndst4 Sult4a1 Sult1b1 Hs3st3b1 Gstcd Hs2st1 Tpmt Naa50 Nat8 Nat2 Ephx1 Akr1a1 Nat9 Sult2b1 Sult6b1 Nat8l Inmt Naa40 Nat10 Comt Nat14 Nnmt Hs3st3a1 Chst1 Sult2a1 Chst3 Chst2 Chst5 Chst4 Chst7 Chst9 Naa30 Chst8 Gstz1 Hs3st4 Hs3st1 Hs3st2 Hs3st5 Hs3st6 Naa20 Akr1d1 Kcnab1 Kcnab2 Sult1e1 Sult1a1 Kcnab3 Ugt1a6 Gal3st1 Ugt1a9 Fmo1 Ugt1a2 Fmo3 Ugt1a1 Fmo2 Fmo5 Hs6st3 Hs6st2 Fmo4 Hs6st1 Akr1b10 Gal3st3 Baat Gal3st2 Cyp2w1 Cyp2u1 Cyp4f3 Cyp2s1 Cyp17a1 Cyp4f39 Cyp39a1 Cyp19a1 Cyp2f2 Ephx2 Cyp1b1 Cyp11a1 Cyp51a1 Cyp7b1 Cyp4x1 Cyp2e1 Cyp2r1 Cyp4v3 Glyat Cyp26c1 Cyp46a1 Cyp27a1 Cyp11b1 Cyp21a1 Cyp20a1 Cyp11b2 Cyp1a1 Hnmt Cyp27b1 Gstk1 Cyp4b1 Cyp8b1 Gsto1 Mgst3 Gsto2 Mgst2 Mgst1 Cyp24a1 Cyp1a2 Gpx2 Cyp7a1 Gpx1 Gpx4 Gpx3 Gpx5 Gstp1 Gstt2 Gstt1 Gsta3 Gsta4 Gsta1 Gsta2 Gstm7 Gstm5 Akr1b1 Cyp26b1 Gstm4 Gstm1 Gal3st4 Cyp26a1 T CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP480%MUS MUSCULUS T cell receptor signaling pathway Mapk1 Abl1 Cabin1 Akt1 Cblb Stat5a Stat5b Grap Mapk7 Dlg1 Itpr1 Cd2ap Creb1 Pik3r1 Pik3r2 Cebpb Ptprc Ppp3cb Cish Map3k1 Ncl Stat1 Braf Crkl Rac2 Rap1a Dtx1 Vav1 Crk Sos1 Was Shc1 Arhgdib Sh2d3c Src Txk Nck1 Pak1 Muc1 Fyn Sla Prkd2 Sit1 Sh2d2a Lax1 Wipf1 Fcrl5 Rasgrp2 Arhgef6 Unc119 Ripk2 Pag1 Tubb5 Map2k2 Fyb1 Ptk2 Homer3 Map2k1 Rapgef1 Pstpip1 Cd8a Grb2 Enah Ptprj Acp1 Ptprh Mapk3 Skap2 Skap1 Vasp Dnm2 Arhgef7 Tuba4a Ptpn12 Pxn Evl Cd247 Cd3g Cd3e Ptpn3 Stk39 Dock2 Fos Cd3d Cd2 Dusp3 Def6 Trat1 Sla2 Nfam1 Wasf2 Grap2 Khdrbs1 Ptpn22 Dbnl Jun Crebbp Bcl10 Vav3 Abi1 Vav2 Itk Zap70 Card11 Cdc42 Git2 Lime1 Lcp2 Prkcq Cd5 Shb Sh3bp2 Nedd9 Jak3 Syk Gab2 Lck Ptpn6 Cbl Map4k1 Sos2 Ptpn11 Lyn Lat Ptk2b Cd4 Ctnnb1 Plcg1 Hdac7 Sh2b3 Rasa1 Nfatc2 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP29%MUS MUSCULUS Notch signaling pathway Notch4 Adam17 Notch2 Notch3 Dll1 Dll3 Kat2b Dll4 Rbpjl Dvl1 Hes1 Hes5 Psen1 Psen2 Ncstn Aph1a Mfng Notch1 Dvl2 Numb Dvl3 Maml3 Numbl Aph1b Dtx1 Tnf Hdac2 Maml1 Hdac1 Rbpj Jag2 Dtx2 Jag1 Dtx3 Cirsr Dtx4 Dtx3l Kat2a Crebbp Rfng Snw1 Ptcra Ctbp1 Lfng Ncor2 Ctbp2 FOCAL ADHESION PI3K AKT MTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2841%MUS MUSCULUS Focal adhesion PI3K Akt mTOR signaling pathway Nos1 Fgf18 Mapk1 Akt1 Ppp2ca Cab39 Kit Mdm2 Raf1 Kitlg Cdkn1a Gng10 Cdkn1b Ikbkb Gng3 Ikbkg Fgf2 Gng5 Gng4 Gng7 Pdpk1 Akt2 Gng8 Gngt1 Gngt2 Pik3r1 Pik3r2 Prl Gnb2 Mtor Acaca Gnb1 Epo Gnb3 Epor Gng11 Efna5 Gng12 Pik3cg Gng13 Pik3cb Pik3cd Fgf13 Pik3ca Slc2a3 Fgf10 Fgf8 Igf1r Egfr Fgfr2 Flt1 Rps6 Angpt1 Mlst8 Akt3 Kdr Rab10 Fgfr3 Pik3r5 Fgfr1 Met Sos1 Pik3r4 Fgf15 Nos3 Pdgfrb Pdgfra Pik3c2b Col11a2 Casp9 Bad Col2a1 Pten Ptk2 Grb2 Eif4e Itga7 Itga8 Itga5 Itga6 Itga9 Itga3 Itga4 Itga2 Itga10 Itga11 Nras Itgax Itgav Itgam Itgae Itgal Rab11b Phlpp1 Itgad Phlpp2 Itgb8 Ppp2r3d Ngfr Itgb7 Ppp2r3c Ulk1 Itgb1 Mtcp1 Itga2b Pik3ip1 Itgb4 Tbc1d1 Itgb5 Fgfr4 Itgb2 Gng14 Fgf4 Fgf16 Itgb3 Rptor Fgf17 Fgf14 Ifnab Osmr Fgf12 Fgf11 Hif3a Fgf20 Fgf21 Fgf22 Ifna4 Ifna5 Hsp90aa1 Jak3 Ifna6 Foxo3 Ifna7 Jak2 Ifna2 Ifna9 Foxa1 Strada Rab8a Comp Ifna1 Fgf3 Csf3r Fgf6 Ppp2r2d Rab2a Ins1 Fgf7 Gh Eif4e1b Ngf Fgf9 Rps6kb1 Irs1 Hsp90ab1 Csf1 Csf3 Kras Ins2 Creb3l3 Irs4 Creb3l4 Creb3l1 Irs2 Crtc2 Csf1r Atf2 Irs3 Akt1s1 Stk11 Cab39l Efna4 Prlr Efna1 Efna2 Efna3 Flt4 Pfkfb4 Lpar6 Pfkfb3 Pfkfb2 Pfkfb1 Vwf Elavl1 Slc2a2 Angpt2 Lpar5 Angpt4 Creb5 Epha2 Ifna13 Ifna14 Ifna11 Ifnar2 Tcl1b4 Tcl1b1 Rab14 Tek Tcl1 Hif1a Insr Rheb Igf1 Lipe Hsp90b1 Epas1 Slc2a4 Cdc37 Foxo1 Creb1 Ghr Ppp2r3a Ppp2r2c Ppp2r2b Osm Ppp2r1b Ppargc1a Ppp2r1a Ppp2r5d Ppp2r5b Ppp2r5a Il6ra Srebf1 Eif4e2 F2r Ppp2cb Gys1 Gys2 Chrm1 Chrm2 Il7r Map2k2 Map2k1 Lpar4 Mapk3 Lpar3 Lama1 Lpar2 Lama2 Lpar1 Lama3 Jak1 Eif4ebp1 Itgb6 Lamb3 Il3ra Thbs1 Rps6kb2 Spp1 Slc2a1 Atf4 Egf Tnc Atf6b Tnn Tnr Tnxb Col5a2 Col5a3 Hgf Gnb4 Col5a1 Pgf Hras Reln Lama4 Thbs2 Fn1 Thbs4 Il2ra Pdgfc Il2rb Pdgfd Il2 Chad Creb3 Pdgfa Pdgfb Vtn Gsk3b Ddit4 Col4a4 Tsc2 Col4a1 Lamb2 Tsc1 Col4a2 Fgf1 Col4a6 Gng2 Ibsp Lamb1 Col1a2 Pelo Col3a1 Col11a1 Vegfa Col1a1 Vegfd Vegfc Ppp2r5c Vegfb Lama5 Eif4b Col6a2 Il2rg Il4ra Lamc3 Pik3c2a Lamc1 Lamc2 Thbs3 Ifnb1 Creb3l2 Nos2 Ppp2r5e Ifnar1 Prkaa1 Prkaa2 Pik3c2g PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2316%MUS MUSCULUS PPAR signaling pathway Acadm Cpt2 Slc27a1 Gk Aqp7 Rxrg Dbi Angptl4 Scp2 Cyp4a30b Lpl Cyp4a32 Olr1 Cyp4a31 Gk2 Cyp4a29 Fads2 Apoa1 Acaa1b Apoa2 Cd36 Pck1 Apoa5 Pltp Pck2 Cyp4a14 Fabp2 Fabp3 Fabp5 Fabp6 Scd4 Acadl Fabp7 Ehhadh Acsbg1 Sorbs1 Acsbg2 Hmgcs2 Mmp1b Scd3 Cyp27a1 Apoc3 Scd2 Rxrb Me1 Slc27a5 Slc27a4 Slc27a2 Acaa1a Cpt1b Cpt1c Slc27a6 Plin1 Adipoq Scd1 Ppard Ppara Pdpk1 Pparg Acsl1 Acsl5 Mmp1a Acsl6 Ucp1 Acsl3 Acsl4 Cyp8b1 Fabp4 Fabp1 Cyp7a1 Ubc Ilk Cyp4a12a Cyp4a12b Cyp4a10 Acox1 Acox2 Acox3 Nr1h3 Cpt1a Rxra TGF BETA RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP258%MUS MUSCULUS TGF beta receptor signaling pathway Cd44 Cdc25a Tgfb1 Sp1 Dvl1 Map3k7 Trp53 Skp1 Axin2 Smad3 Cdk6 Cdk4 Cdk2 Btrc Cdkn1a Pard3 E2f5 Stambpl1 Cdc27 Pias1 Dab2 Cdc23 Pias2 Dcp1a Ctcf Rbx1 Prkar1b Eid2 Hgs Foxo1 Nup153 Gipc1 Sdc2 Cul1 Anapc5 Cdk1 Snip1 Anapc4 Ar Anapc1 Anapc2 Rbl2 Snx4 Rbl1 Trap1 Snx2 Esr1 Snx1 Pik3r1 Prkar2a Anapc7 Pik3r2 Cited1 Snx6 Cops5 Nup214 Sparc Map2k6 Fnta Cdc16 Xpo1 Foxg1 Zeb1 Ncoa1 Tfdp2 Anapc10 Camk2g Smurf2 Rb1 Kpnb1 Stk11ip Camk2d Mapk14 Ppp2r2a Hoxa9 Camk2b Nfyb Camk2a Nfyc Arrb2 Foxo4 Strap Fzr1 Kat2b Ap2b1 Map2k3 Acvrl1 Fosb Mef2a Rock1 Tab1 Mef2c E2f4 Sumo1 Snw1 Hspa8 Yap1 Cav1 Mapk8 Hnf4a Erbin Prkcd Fkbp1a Tgif1 Trp73 Fos Zeb2 Foxh1 Skil Eng Lef1 Ep300 Runx2 Atf3 Jun Junb Tgfbr3 Crebbp Smad2 Smad4 Zfyve9 Tgfbr1 Tgfbr2 Smad6 Smad7 Ube2d3 Ube2d1 Vdr Myc Jund Ets1 Tgfb2 Prkcb Tgfb3 Axin1 Foxo3 Daxx Ube2d2a Eif3i Nfya Ccne1 Atf2 Ctnnb1 Stk11 Ccnd1 Hdac1 Tfdp1 Ccnb2 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260910%WP567%MUS MUSCULUS Eukaryotic transcription initiation Tbp Polr3e Polr3b Polr2a Polr3h Polr2g Mnat1 Polr3k Cdk7 Polr2k Taf13 Taf12 Gtf2h2 Gtf2h4 Gtf2h3 Ercc2 Ercc3 Polr1b Gtf2a2 Polr1c Gtf2b Taf7 Polr1a Taf6 Ilk Taf5 Gtf2e1 Polr1d Gtf2e2 Ak6 Polr2c Gtf2f2 Polr2b Taf9 Polr2h Polr2e Polr2i Polr2j Gtf2h1 Ccnh Polr3d TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP246%MUS MUSCULUS TNF alpha NF kB signaling pathway Rpl8 Mcm5 Relb Akap8 Alpl Fadd Akt1 Skp1 Ppp2ca Rel Eif4a3 Prkaca Nr2c2 Pias3 Btrc Ube2i Ikbkb Polr2h Flna Cdc37 Ikbkg Cul1 Ikbke Akt2 Csnk2a2 Csnk2a1 Mark2 Fbl Ywhah Csnk2b Casp2 Map2k5 Map3k3 Tradd Papola Traf1 Casp8 Casp7 Chuk Tab1 Traf3 Bag4 Map3k14 Nfkbie Map3k1 Birc3 Birc2 Stat1 Nkiras1 Rpl4 Nkiras2 Nlrp4e Kpna2 Rpl6 Unc5cl Dpf2 Kcnq1 Azi2 Ppp1r13l Rnf216 Ddx3x Usp2 Polr1g Fbxw11 Casp8ap2 Txlna Tank Actl6a Smarce1 Tifa Cdc34 Traip Nfkbia Nfkbiz Glg1 Smarca4 Sumo1 Ripk3 Cradd G3bp2 Dcaf7 Cops3 Src Nfkbib Kpna6 Nfkb2 Iqgap2 Mcc Kpna3 Dap Gab1 Map3k2 Bcl3 Tab3 Ccar2 Traf4 Pfdn2 Traf5 Pml Faf1 Tnfrsf8 Smarcc1 Smarcb1 Traf6 Rasal2 Pkn1 Peg3 Bcl7a Cyld Casp3 Fkbp5 Tab2 Tnip2 Pdcd2 Cav1 Nsmaf Ripk2 Zfand5 Cflar Commd1 Ptk2 Trpc4ap Ywhae Fancd2 Ywhab Elp1 Psmd1 Ktn1 Usp11 Smarcc2 Rnf25 Tnip1 Tnfaip3 Lrpprc Mtif2 Nfkb1 Ywhaz Pebp1 Gtf2i Tbk1 Capn3 Crebbp Psmd12 Psmd13 Rpl30 Psmb5 Map3k8 Ripk1 Rps6ka5 Rps11 Psmc2 Rps13 Tnfrsf1b Psmc1 Gsk3b Psmc3 Tnfrsf1a Hsp90aa1 Psmd7 Psmd6 Hspb1 Psmd3 Polr1b Rack1 Polr1c Rela Polr1a Traf2 Polr1d Polr1e Hsp90ab1 Rps6kb1 Prkcz Ptpn11 Mcm7 Ywhag Tnf Hdac2 Hdac1 Hdac6 Tnfrsf11a CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2292%MUS MUSCULUS Chemokine signaling pathway Adcy3 Adcy4 Adcy1 Adcy2 Mapk1 Adcy7 Ccr9 Adcy8 Ccr8 Adcy5 Ccr6 Adcy6 Akt1 Ccr4 Adcy9 Prkx Ccr3 Ccr2 Prkaca Prkacb Stat5b Raf1 Gnai2 Gnai1 Gnai3 Pard3 Gng10 Ikbkb Gng3 Ikbkg Gng5 Gng4 Plcb2 Gng7 Akt2 Gng8 Gngt1 Gngt2 Pik3r1 Pik3r2 Pik3r3 Gnb2 Gnb1 Gnb3 Gnb5 Gng11 Pik3cg Gng12 Pik3cb Gng13 Pik3cd Pik3ca Ccl20 Ccl5 Arrb2 Arrb1 Cxcl12 Cxcr1 Cxcr2 Cxcr3 Rock2 Chuk Cxcr4 Rock1 Cxcr5 Cxcr6 Cxcl15 Stat3 Stat2 Stat1 Braf Crkl Akt3 Rac2 Rap1a Rap1b Ccl4 Ccl3 Vav1 Cxcl1 Fgr Cxcl2 Hck Cxcl5 Pik3r5 Crk Nfkbia Sos1 Shc3 Was Shc1 Gsk3a Shc2 Nfkbib Bcar1 Pak1 Wasl Rasgrp2 Ptk2 Map2k1 Prkcd Grb2 Mapk3 Tiam1 Nfkb1 Tiam2 Pxn Cx3cr1 Shc4 Ppbp Grk1 Grk2 Elmo1 Dock2 Ccl21a Cxcl13 Cxcl14 Ccl27a Xcl1 Ccl19 Ccl17 Ccl9 Ccl11 Ccl8 Nras Ccl12 Ccl7 Ccl6 Ccl1 Pf4 Prex1 Grk5 Cx3cl1 Ccl28 Grk4 Vav3 Ccl26 Ncf1 Ccl24 Grk6 Ccl25 Ccl22 Vav2 Itk Gnb4 Ccr1l1 Gng14 Hras Rhoa Csk Cdc42 Rac1 Gsk3b Ccl2 Plcb1 Prkcb Jak3 Gng2 Foxo3 Jak2 Rela Cxcl10 Cxcl9 Prkcz Sos2 Kras Lyn Ptk2b Ccr10 Ccr1 Xcr1 Cxcl16 Ccr5 Plcb4 Plcb3 HYPOXIA DEPENDENT DIFFERENTIATION OF MYOBLASTS%WIKIPATHWAYS_20260910%WP5025%MUS MUSCULUS Hypoxia dependent differentiation of myoblasts Egln1 Myog Cdkn1a Myf5 Mapk14 Myh1 Cdkn1b Hif1a Myf6 Bhlhe40 Vegfa Hif1an Notch1 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP151%MUS MUSCULUS IL 5 signaling pathway Mapk1 Unc119 Akt1 Map2k2 Csf2rb Rapgef1 Prkcd Grb2 Mapk9 Rps6ka1 Stat5a Mapk3 Btk Dnm2 Nfkb1 Stat5b Jak1 Raf1 Ywhaz Rap1gap Sh2b2 Cdkn1b Alox5ap Alox5 Jun Itgam Pik3r1 Pik3r2 Pla2g4a Sox4 Sdcbp Bax Itgb2 Pik3cg Hras Hcls1 Mapk14 Il2rb Rac1 Pim1 Gsk3b Il5 Prkcb Foxo3 Jak2 Syk Stat3 Icam1 Socs1 Ptpn6 Stat1 Il5ra Elk1 Cbl Crkl Ptpn11 Kras Lyn Ptk2b Atf2 Ccnd3 Ctnnb1 Vav1 Hck Nfkbia Gsk3a Shc1 Shc2 FATTY ACID BETA OXIDATION STREAMLINED %WIKIPATHWAYS_20260910%WP3588%MUS MUSCULUS Fatty acid beta oxidation streamlined Acadm Cpt2 Acads Hadha Hadh Hadhb Slc27a1 Eci1 Slc25a20 Slc27a3 Acat1 Fabp4 Fabp1 Cd36 Fabp2 Fabp3 Acadl Fabp7 Slc27a5 Slc27a4 Slc27a2 Cpt1b Slc27a6 Decr1 Acadvl Acsl1 Echs1 Acsl5 Cpt1a Acsl6 Acsl3 Acsl4 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260910%WP207%MUS MUSCULUS Nucleotide GPCRs Tmigd3 P2ry6 P2ry4 P2ry2 Lpar6 P2ry1 Adora2b Adora2a Adora1 Adora3 Lpar4 Ltb4r TCA CYCLE%WIKIPATHWAYS_20260910%WP434%MUS MUSCULUS TCA cycle Aco2 Idh2 Idh3g Pdhx Suclg2 Pdk3 Sucla2 Idh3a Pdhb Idh3b Pdp1 Pdp2 Cs Dlat Suclg1 Pdk4 Dlst Sdhd Sdhc Pdha1 Sdhb Pdha2 Sdha Dld Pdk2 Pcx Ogdh Fh Pdk1 Mdh1 Mdh2 ID SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP512%MUS MUSCULUS ID signaling pathway Bmpr2 Myf6 Id3 Hes1 Igf1 Smad3 Tgif1 Bmp2 Cdk2 Nfkb1 Myog Bmp6 Myod1 Myf5 Atf3 Tert Tcf3 Rbl2 Egf Rbl1 Smad1 Smad4 Pax2 Smad5 Rb1 Acvrl1 Elk3 Cd40lg Pax5 Pax8 Id2 Tcf12 Id4 Msc Igf1r Vegfa Tcf7l2 Flt1 Rela Psmd4 Lck Elk1 Ngf Srebf1 Irs1 Kdr Ccna2 Ccne1 Ctnnb1 Id1 Elk4 OVARIAN INFERTILITY%WIKIPATHWAYS_20260910%WP273%MUS MUSCULUS Ovarian infertility Tbp Egr1 Cebpb Mlh1 Vdr Ptger2 Fshr Cyp19a1 Nr5a1 Zp3 Inha Zp2 Gdf9 Syne2 Bmpr1b Lhcgr Smad3 Dmc1 Cdk4 Msh5 Pgr Nrip1 Atm Smpd1 Ccnd2 Cdkn1b Prlr Dazl Gja4 Ncor1 Esr2 SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260910%WP1266%MUS MUSCULUS SIDS susceptibility pathways Ascl1 Gata3 Adcyap1r1 Gata2 Nr3c1 Ret Il6 En1 Sp1 Cav3 Nkx2-2 Hes1 Hes5 Htr2a Rora Nfkb1 Htr1a Ctcf Ppargc1b Creb1 Ep300 Ar Lmx1b Gnb3 Ryr2 Ppargc1a Il10 Il6ra Tph1 Maoa Ddc Deaf1 Scn5a Ece1 Ybx1 Nfya Adcyap1 Kcnh2 Chrnb4 Phox2b Chrnb2 Kcnq1 Slc6a4 Hspd1 Cc2d1a Vipr2 Avp Vipr1 Tph2 Phox2a Tnf Nkx3-1 Pou3f2 Foxm1 Cdca7l Tlx3 Fev Chrna4 C4b C4a Rest FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP1269%MUS MUSCULUS Fatty acid beta oxidation Acadm Cpt2 Acads Hadha Hadh Hadhb Gk Eci1 Slc25a20 Acat1 Lpl Gk2 Acadl Lipe Cpt1b Crat Dld Pnpla2 Chkb Gcdh Tpi1 Decr1 Lipc Gpd2 Acss2 Lipf Acadvl Acsl1 Echs1 Acsl5 Cpt1a Acsl6 Acsl3 Acsl4 SPINAL CORD INJURY%WIKIPATHWAYS_20260910%WP2432%MUS MUSCULUS Spinal cord injury Mag Prb1a Klk8 Egr1 Rtn4 Bcan Gdnf Efnb2 Ptpra Cspg4 Nox4 Ltb Btg2 Tgfb1 Ptprz1 Nos1 Slit1 Il6 Slit2 Slit3 Chst11 Rhoc Mapk1 Rgma Vcan Sema6a Mmp12 Ccng1 Tnfsf13 Cd47 Sox9 Ncan Xylt1 Trp53 Ccr2 Cdk4 Cdk2 Grin1 Acan Il1b E2f5 Cdk1 Rtn4r Gadd45a Anxa1 Ppp3ca Rb1 Rock2 E2f1 Tnfsf13b Gap43 Tacr1 Mmp9 Gfap Epha4 Mbp Cxcl1 Cxcl2 Rhob Tlr4 Casp3 Col2a1 Arg1 Fkbp1a Ltb4r Mapk3 Ifng Nr4a1 Ntn1 Gja1 Fos Pla2g2a Selp Vim Pla2g6 Ngfr Bdnf Rhoa Myc Il2 Il4 Ccl2 Fcgr2b Col4a1 Prkca Icam1 Cxcl10 Nos2 Ccnd1 Tnf Pla2g5 Il1a Aqp4 Pdyn Zfp36 Omg Il1r1 Pirb C5 Plxna2 ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260910%WP339%MUS MUSCULUS ESC pluripotency pathways Bmpr2 Dvl1 Mapk1 Fgf18 Wnt1 Akt1 Fzd1 Lif Bmp4 Bmpr1a Mdm2 Raf1 Hnf1a Fzd4 Mapk7 Fgf2 Acvr1 Mapk4 Akt2 Il6st Pik3r2 Mtor Map2k6 Map2k5 Lrp6 Lrp5 Pik3cd Fgf13 Fgf5 Map2k3 Fgf8 Fgf10 Egfr Fgfr2 Stat3 Braf Elk1 Mapk6 Akt3 Selenop Araf Eras Fgfr3 Fgfr1 Sos1 Fgf15 Pdgfrb Gab1 Pdgfra Mapk12 Pten Map2k2 Map2k1 Fgf23 Grb2 Jak1 Nog Fos Actr2 Jun Egf Smad1 Smad4 Smad9 Smad5 Smad6 Fgfr4 Smad7 Fgf4 Hras Fgf16 Fgf17 Wnt5a Fgf14 Myc Fgf12 Wnt10a Fgf11 Pdgfa Pdgfb Fgf20 Gsk3b Fgf21 Fgf22 Fgf1 Axin1 Wnt9b Wnt16 Wnt11 Fgf3 Wnt6 Fgf6 Bmpr1b Wnt7b Wnt3a Fgf7 Dvl2 Dvl3 Fgf9 Wnt7a Wnt2 Ptpn11 Wnt4 Wnt3 Fzd3 Fzd2 Ctnnb1 Fzd5 Lifr Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Wnt10b Apc POLYOL PATHWAY%WIKIPATHWAYS_20260910%WP1265%MUS MUSCULUS Polyol pathway Akr1b1 Sord Aldob Khk MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260910%WP2910%MUS MUSCULUS Mecp2 and associated Rett syndrome Mag Cebpd Sp3 Fgf4 Oprk1 Hnrnpf Rbfox1 Sp1 Nf1 Mef2c Gamt Fgf3 E2f1 Mecp2 Cnp Gprin1 Csrp1 Smc3 Fut8 Ybx1 Pou4f1 Gad1 Ezh2 Grin1 Apoc2 Gabrr2 Nrep Dlx5 Myt1 Arhgef26 Sst Taf1 Tap1 Cdon Ctcf Mbp Pou3f2 Creb1 Tet1 Fgf2 Hnrnph1 Prpf3 Ncor1 Sin3a Bcl6 Bdnf Rest FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5128%MUS MUSCULUS Fibrin complement receptor 3 signaling pathway Itgb2 Irak1 Rhoa Pik3ca Traf6 Il6 Ccl2 Chuk Akt1 Syk Cblb Rela Tyrobp Rel Cxcl10 Nfkb1 Fcer1g Ifnb1 Irf3 Nos2 Rassf5 Ikbkb Il12b Tnf Lbp Cxcl3 Cd14 Ikbkg Ly96 Fgb Fga Ticam2 Irak4 Itgam Ticam1 Fgg Irak2 Plat Myd88 Plg Src Tlr4 Tirap Tlr3 LAC PHE PATHWAY%WIKIPATHWAYS_20260910%WP5240%MUS MUSCULUS Lac Phe pathway Cndp2 Abcc5 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260910%WP79%MUS MUSCULUS Tryptophan metabolism Hadh Cat Hsd17b10 Acat1 Cyp1a2 Prmt1 Wars1 Cyp19a1 Tdo2 Cyp2f2 Cyp1b1 Maob Cyp7b1 Cyp2e1 Aanat Tph1 Rnf25 Ddc Asmt Mdm2 Inmt Dhcr24 Cyp4f14 Aldh1a2 Ogdh Aldh3a2 Ube3a Aldh9a1 Cyp2j6 Gcdh Cyp2c55 Aldh1a1 Aadat Ubr5 Aldh2 Aox1 Afmid Cyp1a1 Aoc1 Echs1 Haao Kynu Acmsd Ido1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260910%WP578%MUS MUSCULUS Leptin insulin signaling overlap Ins1 Dgkz Lepr Socs3 Irs1 Pik3cg Irs4 Socs2 Irs2 Irs3 Insr Pdpk1 Akt1 Jak2 Lep Stat3 Pik3r3 Socs1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP300%MUS MUSCULUS Histone modifications Hdac1 Hat1 Ehmt2 Hdac2 Ehmt1 ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20260910%WP3864%MUS MUSCULUS Robo4 and VEGF signaling pathways crosstalk Robo4 Kdr Vegfa Rac1 Src Slit2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260910%WP412%MUS MUSCULUS Oxidative stress response Ugt1a1 Mt1 Gabpb1 Txn2 Txnrd1 Nqo1 Nfix Hmox1 Txnrd2 Cat Gsr Mapk14 Sod3 Sod2 Sod1 Mgst1 Cyba Sp1 Gpx1 Gpx3 Maoa Gstt2 Nfkb1 Fos Gclc Junb Mapk10 Cyp1a1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260910%WP189%MUS MUSCULUS GPCRs class A rhodopsin like Or13j1 Or8b12c Or10d1 Or8b12i Or8c15 Or8c16 Or2d3b Or8d2b Or8d1b Tcp10b Or11h4 Fpr2 Or8b12 Or8b40 Or8b39 Or8b101 Or6e1 Or10j5 Gpr45 Or2ag2 Or2ag1 Or8g23 Or8g24 Or8g26 Or8g27 Or8c8 Or8g28 Or8g18 Or10d4b Or10d4c Or10d1c Or8g2b Or2ag19 Or8g32 Or8g34 Or8g35 Or8g36 Or8g37 Or6b6 Or2ag20 Or13c7d Or13c7 Or13c7b Or8g30 Or2d2 Or2d4 Or2d3 Or8g53 Or8g55 Or13e8 Or8d23 Or8a1 Or8g20 Fpr-rs4 Fpr-rs3 Or8b4 Or2d36 Or10a4 Or10a5 Or10a2 Or8g19 Or6a2 Or2ag2b Trhr2 Rho Adora2b Adora2a Ednrb Rrh Htr4 Ptgdr Trhr Htr6 Htr7 Oprd1 C3ar1 Galr2 Galr1 Sstr5 Avpr2 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Avpr1a Htr5b Htr5a Tbxa2r Fpr1 Nmbr Ptgfr Agtr1a Agtr1b Ccr1 Oxtr Npy6r Grpr Cckar Nmur1 Ntsr2 Ntsr1 Ptger4 Mc2r Ptger2 Gabbr1 Ptger3 Fshr Ptger1 Ccr9 Ccr8 Gpr63 Ccr6 Ccr4 Ccr3 Ccr2 Mtnr1a Or8g17 Cckbr Cmklr1 Agtr2 Mc1r Rgr Mc4r Or10n1 Ptafr Cysltr1 Mc3r Gpr87 P2ry13 P2ry12 Gpr83 P2ry14 Mas1 Gpr50 F2rl1 F2rl2 F2rl3 Adra2a Or6b9 Gpr19 Adra2c Hcar2 Or5p57 Or2c1 Adra2b Gpr12 Cxcr2 Npy1r Cxcr3 Gpr65 Cxcr4 Cxcr5 Adrb2 Opn1sw Or8a1b Adrb1 Adra1b Adra1a Adrb3 Adra1d Lhcgr Gpr27 Mc5r Oprm1 C5ar1 Or7a40 F2r Aplnr Bdkrb2 Gpr37 Bdkrb1 Gpr33 Chrm1 Hrh1 Chrm3 Gpr35 Chrm2 Gpr34 Chrm4 Hrh2 Drd3 Drd4 Opn4 Opn1mw Opn3 Ccrl2 Gper1 Adora3 Ptgdr2 Npy5r Tmigd3 Htr2a Htr2c Htr2b Gpr37l1 Ltb4r Or8b8 Npy4r Cx3cr1 Ptgir Gpr3 Htr1d Htr1f Htr1b Htr1a Tshr P2ry6 P2ry4 P2ry2 P2ry1 Ackr3 Npy2r Cnr1 Ackr2 Cnr2 Ccr1l1 Oprk1 Oxt Avp Brs3 Fpr-s1 Oprl1 Ccr5 Galr3 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260910%WP1263%MUS MUSCULUS Mitochondrial gene expression Tfb1m Tfb2m Mterf1a Gabpb2 Mterf3 Tfam Pprc1 Polrmt Ppp3ca Camk4 Gabpa Ppargc1a Nrf1 Ppargc1b Myef2 Sp1 Hcfc1 Creb1 Esrra SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260910%WP2140%MUS MUSCULUS Serotonin and anxiety related events Ppp3ca Nlgn1 Fos Htr1a Grin2d Prkcb Plek Plcd4 Crhr1 Arc Htr2a Htr2c Crh IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP37%MUS MUSCULUS IL 1 signaling pathway Sqstm1 Irak1 Il1rap Peli1 Tollip Traf6 Sirpa Capns1 Il1rn Mapk1 Map3k7 Tab2 Chuk Casp1 Akt1 Mapk8 Tab1 Map2k1 Elp1 Map3k14 Rela Mapk3 Nfkb1 Ptpn11 Prkcz Il1b Capn1 Plcg1 Irak4 Nfkbia Irak3 Irak2 Il1a Myd88 Il1r2 Il1r1 Nfkbib ESTROGEN SIGNALING%WIKIPATHWAYS_20260910%WP1244%MUS MUSCULUS Estrogen signaling Hdac8 Polr2a Gper1 Polr2g Sp1 Mapk1 Akt1 Map2k1 Bcl2 Grb2 Mapk9 Prkaca Nfkb1 Polr2c Gtf2f2 Fos Polr2b Taf9 Ikbkb Polr2h Polr2e Ikbkg Creb1 Polr2f Brca1 Ep300 Polr2i Polr2j Jun Gnas Gtf2h1 Crebbp Gngt1 Ncor1 Esr1 Sin3a Tbp Gnb1 Hras Mnat1 Mapk14 Pik3ca Cdk7 Polr2k Taf13 Taf12 Chuk Gtf2h2 Gtf2h4 Gtf2h3 Ercc2 Ercc3 Gtf2a2 Gtf2b Taf7 Taf6 Ilk Taf5 Gtf2e1 Braf Gtf2e2 Elk1 Ak6 Hdac3 Ccnd1 Hdac2 Hdac5 Hdac4 Hdac1 Hdac7 Hdac6 Sos1 Shc2 Ccnh Src GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260910%WP157%MUS MUSCULUS Glycolysis and gluconeogenesis Hk1 Pdhx Gpi Eno3 Eno2 Mpc1 Mpc2 Pgam2 Pck1 Pgam1 Slc2a5 Gapdh Ldhc Fbp1 Pfkl Fbp2 Ldhal6b Aldob Gapdhs Pfkm Aldoc Aldoa EG433182 Pgk1 Pgk2 Pkm Pfkp Ldha G6pc1 Hk2 Hk3 Pklr Dld Slc2a4 Slc2a1 Pcx Mdh1 Mdh2 Pdhb Dlat Slc2a3 Ldhb Pdha1 Pdha2 Got1 Got2 Tpi1 Gck Slc2a2 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY %WIKIPATHWAYS_20260910%WP4690%MUS MUSCULUS Sphingolipid metabolism integrated pathway Sphk2 Sphk1 Cers5 Sgpl1 Smpd1 Cers6 Cers2 Plpp3 Cers4 Cers3 Plpp1 Asah1 Cers1 Sgms1 Sgms2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Degs1 Gdf1 Kdsr Sgpp2 Ugcg Sgpp1 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260910%WP222%MUS MUSCULUS Cytokines and inflammatory response Tgfb1 Il2 Il6 Il10 Il4 Pdgfa Il5 Ifna1 Ifng Ifnb1 Csf1 Csf3 Il11 H2-Eb1 Il15 Il1b Il13 Il12a Cd4 Il7 Csf2 Il12b Tnf Il3 Cxcl1 Cxcl3 Il1a LUNG FIBROSIS%WIKIPATHWAYS_20260910%WP3632%MUS MUSCULUS Lung fibrosis Hmox1 Tgfb1 Il6 Ccr3 Ccr2 Nfe2l2 Igf1 Dsp Mecp2 Il1b Il13 Csf2 Grem1 Il12b Eln Skil Atp11a Parn Fgf2 Sftpa1 Ccl11 Fam13a Spp1 Mmp2 Mt2 Elmod2 Dpp9 Tert Sftpc Cysltr2 Cma1 Egf Calca Muc5b Edn1 Stn1 Timp1 Rtel1 Ptx3 Hgf Cebpb Smad7 Ccn2 Ccl5 Il4 Pdgfa Ccl2 Pdgfb Il5 Fgf1 Tgfa Cxcl15 Fgf7 Mmp9 Csf3 Ccl4 Ccl3 Tnf Cxcl2 Bmp7 Plau GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260910%WP4820%MUS MUSCULUS GDNF RET signaling axis Spry1 Pax2 Ift25 Agtr2 Sox11 Gli3 Fat4 Sall1 Gata3 Robo2 Gdnf Ret Gfra1 Ctnnb1 Grem1 Slit2 Foxc2 Lhx1 Bmp4 Eya1 Sox17 Foxc1 Ift27 STATIN PATHWAY%WIKIPATHWAYS_20260910%WP1%MUS MUSCULUS Statin pathway Apoc3 Lrp1 Soat1 Apoc2 Apoc1 Lcat Scarb1 Apoa4 Apoe Lpl Hmgcr Abca1 Apoa1 Cyp7a1 Dgat1 Pltp Ldlr Lipc Mttp EICOSANOID METABOLISM VIA LIPOXYGENASES LOX %WIKIPATHWAYS_20260910%WP4348%MUS MUSCULUS Eicosanoid metabolism via lipoxygenases LOX Ggt5 Dpep2 Mgst3 Mgst2 Cyp4f3 Gpx1 Hpgd Gpx4 Ephx2 Ehhadh Acaa1a Cyp4a12a Cyp4f14 Alox12 Cyp4a12b Alox5 Cyp4a10 Dpep1 Lta4h Ptgr2 Alox15 Ptgr1 Acox1 Acox2 Acox3 Ggt1 Ltc4s FAS PATHWAY AND STRESS INDUCTION OF HSP REGULATION%WIKIPATHWAYS_20260910%WP571%MUS MUSCULUS FAS pathway and stress induction of HSP regulation Pak1 Dffa Pak2 Rb1 Faf1 Lmnb1 Ptpn13 Lmnb2 Casp9 Prkdc Mapkapk3 Sptan1 Map2k4 Casp3 Dffb Map3k7 Casp8 Ripk2 Fasl Casp7 Cflar Fadd Hspb1 Mapk8 Bcl2 Daxx Map3k1 Fas Mapkapk2 Tnf Parp1 Apaf1 Jun Il1a Arhgdib Lmna Casp6 MAPK CASCADE%WIKIPATHWAYS_20260910%WP251%MUS MUSCULUS Mapk cascade Map2k6 Map3k2 Hras Mapk14 Map3k3 Mapk12 Map2k4 Map2k3 Rasa3 Mapk1 Map2 Sipa1 Map2k2 Map2k1 Map3k1 Mapk3 Braf Elk1 Raf1 Kras Mbp Araf Nras Rras Jun Mapk10 Plcb3 Map3k12 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260910%WP683%MUS MUSCULUS Leptin and adiponectin Lepr Acaca Adipor2 Adipor1 Prkag1 Lep Adipoq Prkab1 Prkaa1 Cpt1a IRON HOMEOSTASIS%WIKIPATHWAYS_20260910%WP1596%MUS MUSCULUS Iron homeostasis Il6 Tnf Il6ra Slc40a1 Ftl1 Hamp2 Il1a Tf Hjv Hfe Tfr2 Ireb2 Hamp Fth1 APOPTOSIS%WIKIPATHWAYS_20260910%WP1254%MUS MUSCULUS Apoptosis Mcl1 Casp9 Bad Casp3 Fadd Cflar Bcl2l11 Akt1 Trp53 Bcl2 Igf1 Tnfrsf10b Nfkb1 Mdm2 Trp73 Bid Hells Ikbkb Ikbkg Birc5 Jun Irf6 Pik3r1 Casp6 Casp2 Bax Ripk1 Dffa Myc Tradd Tnfrsf1b Traf1 Map2k4 Dffb Tnfrsf1a Casp8 Fasl Casp7 Chuk Casp1 Traf3 Igf1r Bak1 Rela Nfkbie Hrk Birc3 Map3k1 Fas Prf1 Traf2 Birc2 Trp63 Bok Igf2 Bcl2l2 Tnfsf10 Bnip3l Scaf11 Pmaip1 Lta Irf7 Irf3 Irf5 Gzmc Tnfrsf21 Casp4 Tnfrsf25 Xiap Irf4 Diablo Tnf Irf1 Irf2 Bcl2l1 Apaf1 Nfkbia Mapk10 Cradd Nfkbib MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP401%MUS MUSCULUS Mitochondrial long chain fatty acid beta oxidation Acadm Cpt2 Acads Hadha Hadh Eci1 Slc25a20 Scp2 Pecr Acadvl Acsl1 Acadl Ehhadh Cpt1a Acsl3 Acsl4 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4350%MUS MUSCULUS Omega 3 omega 6 fatty acid synthesis Pla2g4a Acot1 Acot2 Fads2 Pla2g5 Acox1 Pla2g4b Fads1 Acox3 Pla2g6 Acsl1 Elovl2 Elovl5 Acsl3 Acsl4 RETINOL METABOLISM%WIKIPATHWAYS_20260910%WP1259%MUS MUSCULUS Retinol metabolism Rlbp1 Lrat Rarb Rxrg Rarg Scarb1 Lpl Abcg5 Cd36 Cyp2e1 Sult2b1 Rxrb Rara Dhrs3 Rdh8 Rdh12 Aldh1a3 Cyp26b1 Aldh1a2 Rdh10 Bco2 Bco1 Npc1l1 Adh4 Rbp7 Aldh1a1 Abcg8 Adh1 Rpe65 Rbp4 Rbp2 Retsat Rbp1 Sult1a1 Rdh5 Rxra Crabp1 Cyp26a1 Crabp2 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260910%WP327%MUS MUSCULUS GPCRs class C metabotropic glutamate pheromone Gprc5c Casr Gprc5b Gprc5a Gabbr1 Gprc5d Grm1 Gabbr2 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260910%WP523%MUS MUSCULUS Regulation of actin cytoskeleton Ezr Arhgef4 Myh10 Rdx Msn Ssh3 Ssh2 Ssh1 Vil1 Cyfip2 Brk1 Baiap2 Diaph3 Apc2 Mapk1 Fgf18 Rassf7 Fgd1 Tmsb4x Arhgap35 Gsn Wasf1 Pip5kl1 Abi2 Raf1 Gna12 Fgf2 Mapk4 Slc9a1 Pik3r1 Pik3r2 Pik3r3 Pik3cg Gng12 Pik3cb Pik3cd Fgf13 Fgf5 Pik3ca Mylk Rras2 Rock2 Rock1 Arpc5 Fgf8 Fgf10 Egfr Pik3c3 Fgfr2 Braf Mapk6 Rac2 Rac3 F2r Bdkrb2 Bdkrb1 Cd14 Vav1 Chrm1 Myl3 Chrm3 Fgfr3 Pik3r5 Chrm2 Crk Fgfr1 Chrm5 Sos1 Chrm4 Pik3r4 Gna13 Arhgef1 Was Fgf15 Iqgap1 Dock1 Bcar1 Pak1 Nckap1 Pdgfrb Diaph1 Cfl1 Pdgfra Cfl2 Pak6 Pak3 Pak2 Pak5 Myl1 Pak4 Limk1 Pik3c2b Pfn1 Pip4k2a Arhgef6 Map2k2 Ptk2 Git1 Map2k1 Fgf23 Enah Mapk3 Vcl Arhgef7 Pxn Itga1 Wasf2 Nras Rras Pip4k2b Egf Pip4k2c Ppp1r12a Actb Fgfr4 Fgf4 Actn1 Fgf16 Fgf17 Rhoa Csk Fn1 Fgf14 Cdc42 Rac1 Fgf12 Fgf11 Pdgfa Pdgfb Fgf20 Actg1 Fgf21 Fgf22 Fgf1 Pip5k1b Pip5k1a Fgf3 Mras Fgf6 Ins1 Fgf7 Pip5k1c Pik3c2a Fgf9 Sos2 Kras Ins2 Apc Mos F2 Pik3c2g MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260910%WP441%MUS MUSCULUS Matrix metalloproteinases Mmp12 Mmp13 Mmp23 Mmp24 Mmp25 Mmp27 Mmp28 Bsg Mmp7 Mmp20 Mmp21 Mmp11 Mmp14 Mmp15 Mmp3 Mmp16 Mmp9 Mmp17 Timp3 Mmp19 Timp2 Mmp8 Timp4 Tcf20 Mmp10 Tnf Mmp2 Timp1 Mmp1a EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES%WIKIPATHWAYS_20260910%WP4349%MUS MUSCULUS Eicosanoid metabolism via cytochrome P450 monooxygenases Cyp2c29 Cyp2c38 Cyp2c39 Cyp4a12a Cyp4f14 Cyp2c37 Cyp2c23 Cyp4a12b Cyp4f3 Cyp2j5 Cyp4a10 Cyp2c54 Cyp2c40 Ppara Ephx2 Cyp2c55 METHYLATION%WIKIPATHWAYS_20260910%WP1247%MUS MUSCULUS Methylation Pnmt Inmt Comt Nnmt Mat2a Tpmt Hnmt Mat1a Mat2b CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260910%WP163%MUS MUSCULUS Cytoplasmic ribosomal proteins Rpl38 Rpl8 Rps23 Rpl39 Rpl9 Rpl7 Rps24 Rpl32 Rpl26 Rpl22 Rps4x Rpsa Rps6ka1 Rps6kb2 Rps15 Rps16 Rpl3 Rps17 Rps18 Rps15a Rps19 Rpl35 Rpl36 Rps27a Rpl19 Rps10 Rps12 Rpl31 Rpl11 Rpl30 Rpl34 Rpl12 Rpl36a Rps3a1 Rps8 Rps5 Rpl37a Rplp2 Rpl24 Rpl27 Rps14 Rpl28 Rpl29 Rpl21 Rps11 Rplp0 Rps13 Rplp1 Rpl13a Rps6ka2 Rpl18a Rpl13 Rpl15 Rpl17 Rpl18 Rpl10 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps26 Rps7 Rpl27a Rps21 Rpl41 Rps6 Rpl35a Fau Rpl23a Rpl4 Rps6ka3 Rpl6 Rps27 Rps28 Rps29 Rps20 Rpl37 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260910%WP386%MUS MUSCULUS Triacylglyceride synthesis Gnpat Mogat1 Mogat2 Agpat2 Plpp2 Agpat5 Lipe Gk Agps Gpd1 Agpat3 Agpat1 Lpl Plpp3 Pnpla2 Plpp1 Gk2 Dgat2 Gpam Dgat1 Agpat4 Lipc Lipf AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260910%WP1262%MUS MUSCULUS Aflatoxin B1 metabolism Gstt1 Gstm1 Akr7a2 Ephx1 Cyp1a2 REGULATION OF CARDIAC HYPERTROPHY BY MIR 208%WIKIPATHWAYS_20260910%WP1526%MUS MUSCULUS Regulation of cardiac hypertrophy by miR 208 Gata4 Mstn Gja5 Med13 Hopx Myh7 HYPERTROPHY MODEL%WIKIPATHWAYS_20260910%WP202%MUS MUSCULUS Hypertrophy model Hbegf Eif4e Ifng Myog Zeb1 Eif4ebp1 Adam10 Dusp14 Jund Wdr1 Ankrd1 Ifrd1 Ccn1 Nr4a3 Atf3 Mstn Il18 Il1a Vegfa Il1r1 P53 SIGNALING%WIKIPATHWAYS_20260910%WP2902%MUS MUSCULUS p53 signaling Rrm2b Pidd1 Gtse1 Cop1 Serpine1 Mdm4 Ppm1d Chek1 Chek2 Casp9 Casp3 Ccng1 Pten Trp53 Igf1 Cdk6 Cdk4 Cdk2 Mdm2 Trp73 Bid Atm Cdkn1a Sfn Atr Thbs1 Igfbp3 Cdk1 Gadd45b Rrm2 Gadd45a Bax Ccng2 Tsc2 Casp8 Perp Rchy1 Fas Pmaip1 Ccne1 Ccnd2 Ccne2 Cycs Ccnd3 Cyct Ccnd1 Zmat3 Bbc3 Cdkn2a Apaf1 Ddb2 Adgrb1 Serpinb5 Shisa5 Cd82 Ei24 Siah1b Ccnb2 Siah1a Ccnb3 Rprm Gadd45g Ccnb1 Sesn2 Sesn1 Sesn3 Steap3}