LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260910%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 MCCC2 ECHS1 MCCC1 HSD17B10 ACADSB ACSF3 ACAT1 PCCA IVD PCCB DBT MLYCD BCAT1 DLD BCAT2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260910%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 FOSL1 CCND1 EGF MYC ERBB2 HEL113 PGR TIMP1 AREG OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260910%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF CNP CXCL1 ASCL1 FGF2 TNF CXCL2 SHH MBP SOX8 SOX9 SOX6 SOX5 NKX2-2 NKX2-6 MOG LIF OMG OLIG1 OLIG2 IGF1 SOX10 MYT1 BMP4 BMP2 IL1B LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260910%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT LMNA ZMPSTE24 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260910%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis TRADD RIPK1 FADD TICAM1 FTL TNF TNFRSF1A MAPK8 CASP8 RIPK3 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260910%WP100%HOMO SAPIENS Glutathione metabolism HEL-S-64p GSTM2 GPX2 GPX1 GSTM1 GPX4 GPX3 GSTT2 OPLAH HEL-S-26 HEL-75 GCLC GSTA5 GCLM WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260910%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 NEUROD1 FZD3 WNT3A CCND1 WNT7A PROX1 WNT3 NEUROG2 LRP6 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260910%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT3 MTOR DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260910%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR1 AGTR2 ACE2 IL6 SIGNALING%WIKIPATHWAYS_20260910%WP364%HOMO SAPIENS IL6 signaling GRB2 SOS1 VIP IL6ST BCL2L1 TIMP1 CRP GSK3B SHC1 HDAC1 IRF-1 PIK3R2 PIK3R1 NLK SOCS3 MAPK1 RAC1 MAP3K7 JUNB IL6R MAPK3 JAK1 NCOA1 MAP2K4 MAP2K1 CREBBP MAP2K2 STAT1 BAD STAT3 PTPN11 TYK2 VAV1 NR2F6 IL6 RPS6KB1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260910%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL10 TNF CXCL8 CCL11 IFNA2 IL18 TMPRSS2 FURIN MAPK1 HMGB1 IL2 GFAP IL4 IL1A IFNG TLR8 IL12A TLR7 TLR4 TLR3 IL1B IL6 ACE2 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FZD9 SMAD9 FZD8 FGF18 FGFR4 FGFR3 FGFR2 BMPR1A FGF10 FGFR1 WNT2B BMPR2 PIK3CD PIK3C2G GLI3 PIK3C2B HEY2 DKFZp781O1323 WNT9B WNT9A WNT16 MYOD1 PPARG LRP5 WNT8A WNT8B DLL3 DLL4 MAPK9 MAPK7 HES3 MAPK6 HES2 MAPK4 WNT7B MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 FGF2 SOX9 BMP4 BMP2 MAPK8 FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 PIK3R2 PIK3R1 MAPK1 MAPK3 STAT1 IHH FZD10 RBPJ FGF3 FGF4 FGF6 FGF7 FGF8 FGF9 HES6 PRKCI PRKCH WNT5B PRKCB PRKCE PRKCA RUNX2 SMO PRKCQ PRKD1 NOTCH2 NOTCH3 NOTCH1 PRKDC NOTCH4 PIK3R4 PIK3R3 PRKCZ PIK3R5 WNT1 WNT4 JAG2 WNT10B SMAD1 WNT10A SMAD4 FZD2 FZD5 FZD4 FZD7 PTCH1 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response RB1 H2AX CDKN1A CDKN1B HUS1B BBC3 CASP9 TP53AIP1 PIDD1 CCND3 CCND2 CHEK2 CASP3 SESN1 CHEK1 TLK2 TLK1 NBN APAF1 RFC1 SMC1A DDB2 CREB1 CCNE2 RRM2B FANCD2 CCNE1 CCNB3 CCNB2 CCNB1 PMAIP1 SFN ATRIP GADD45B GADD45A MRE11A TNFRSF10B PML CDC2 GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CCNG1 CDK2 CCND1 MDM2 BAX MYC CYCS RAD17 RAD1 ATM RAD9A ATR PRKDC CASP8 FOXA2 PATHWAY%WIKIPATHWAYS_20260910%WP5066%HOMO SAPIENS FOXA2 pathway ABCC3 FOXA1 ABCC2 IRS1 MTTP ACACA FOXO1 GSTM2 INS SLCO1B1 MLXIPL FASN APOB PPARGC1B SLC27A5 FOXA2 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome FANCD2 GOLGA8R ARHGAP11B MTMR10 KLF13 CHRNA7 OTUD7A CREBBP GPR75 GOLGA8O GOLGA8Q TRPM1 KAT2B GRM6 CCL5 GOLGA8H CHRFAM7A FYN FAN1 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260910%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TGFB1 CD80 IRAK4 IL2RG NFKB1 TGFBR2 NFKB2 SOCS1 TRAF6 IL2RA IL2RB CCL2 CTLA4 IL4 PDCD1 TLR8 TLR7 TLR4 STAT3 CCL5 LUNG FIBROSIS%WIKIPATHWAYS_20260910%WP3624%HOMO SAPIENS Lung fibrosis TGFB1 CCL2 CSF3 CSF2 SERPINA1 CTGF MT2A KPG_011 IL12B CCR3 CCR2 EDN1 HGF ELMOD2 SFTPC MMP2 IL13 ATP11A opn MMP9 GREM1 CALCA CEBPB RTEL1 SFTPA2 PDGFA TGFA TERT DPP9 CCL4 CCL3 HMOX1 SKIL STN1 CMA1 MUC5B BMP7 IL5 PTX3 SFTPA1 NFE2L2 IL6 CXCL8 CCL11 IL4 EGF FGF7 TIMP1 FGF2 TNF CXCL2 IGF1 IL1B CCL5 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260910%WP5088%HOMO SAPIENS Prostaglandin signaling IRF7 IL17F TGFB1 KLRD1 IL17A PTGES CXCL8 NFKB1 CCL2 IL1A IFNG IL12A CCR2 AREG MMP9 CXCL1 TNF CCL3 PTGER4 CXCL9 IFNA1 IL1B CSF1 PTGER2 AHR PYCARD NLRP3 IL6 VEGFA PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260910%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGES PTGER1 ALOX15 PTGER3 ADCY3 ALOX12 LTC4S PTGS2 GNAI1 PTGS1 NRAS ALOX5 HRAS PTGIS IGFBP5 SIRT1 ALOX15B PRXL2B ALOX5AP GNAS MAPK11 RB1 CDKN1A PTGER4 PTGER2 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260910%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNLL2 WDR35 DYNC2LI1 DYNC1LI1 IFT22 DYNC1LI2 IFT43 IFT81 IFT27 DYNLRB2 DNCL1 IFT46 DYNC1I1 IFT25 DYNC2H1 DYNC2I2 DYNC1H1 DYNLT1 IFT140 DYNLT3 DYNLT2B IFT80 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260910%WP5572%HOMO SAPIENS Nucleosome remodeling complex SUPT16H PRKDC H4C9 PCNA HIST1H4L XRCC5 SSRP1 CHEK2 CHAF1B CHAF1A RBBP4 NASP HAT1 SMIM40 ASF1A ASF1B MCM2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5049%HOMO SAPIENS Glycolysis in senescence ENO1 HEL-S-68p HEL-S-162eP RB1 PRKAA1 HEL-S-30 HEL-S-133P IL4 SIGNALING%WIKIPATHWAYS_20260910%WP395%HOMO SAPIENS IL4 signaling GRB2 SOS1 CEBPA ATF2 IL2RG CBL RELA NFKB1 IKBKB INPP5D SOCS1 FLNA EP300 JAK3 PIK3CD SOCS5 STAT5B CHUK GAB2 IL4 FOS NFKBIA FES PTPN6 IRS1 MAPK14 CEBPB SHC1 PIK3R2 MAPK11 PIK3R1 SOCS3 MAPK1 MAPK3 JAK1 STAT1 BAD STAT3 PTPN11 TYK2 RPS6KB1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260910%WP5236%HOMO SAPIENS Markers of kidney cell lineage DKFZp781O1323 CITED1 EPO TNC SIX1 TCF21 SALL1 SIX2 HNF4A KDR RSPO3 RSPO1 DACT1 EMX2 FOXD1 OSR1 KCTD1 HNF1A AXIN2 DCN PAX2 ACTA2 SFRP1 ALDH1A2 KIT PECAM1 TSHZ3 NTN1 NT5E EGLN1 EGLN3 EGLN2 BMP7 EYA1 PBX1 TBX18 DES GDNF NPHS1 NPHS2 WT1 TLX1 LHX1 REN FAT4 TCF2 VSX2 FGF7 FGF8 NOTCH2 NOTCH1 WNT4 BMP4 SMAD1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260910%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260910%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling IFITM3 ATF2 IFITM1 IFITM2 RPS6KA2 RPS6KA1 EIF4E MAP2K6 MAP2K3 JUN MAP3K1 BST2 IFI27 DDIT3 FOS BCL2 MAP3K10 RAF1 MAP3K11 MAPK9 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 MAPK1 JUNB MAPK3 MAP2K4 MAP2K1 MAP2K2 MAPK8 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260910%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP1A2 CYP3A4 UGT1A10 TPMT HEL-S-75 Em:AP000351.3 CYP46A1 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 CYP1B1 SULT2A1 HEL-S-166mP UGT2B11 UGT2B15 UGT2B17 SULT2B1 CYP27A1 CYP2U1 CYP2E1 SULT6B1 NNMT HS3ST3A1 MGST3 MGST1 MGST2 CYP2C19 CYP4F22 CYP2C18 SULT1A1 CYP27B1 CYP2B6 CYP4X1 CHST11 CHST12 CYP11A1 CHST10 CHST13 CHST14 SULT1A4 SULT1A2 NAA50 CYP2J2 GSTM4 GATF-C GSTM3 GLYATL2 HEL-S-165mP EPHX2 CYP4F2 HEL-S-64p EPHX1 GSTM2 CYP4F3 CYP4F11 GPX2 CYP4F8 GSTM1 CYP4F12 SULT1B1 GPX4 CYP26A1 GPX3 GSTT2 CYP2C9 CYP27C1 AKR1B10 NAT8 HEL-75 CYP11B2 NAT2 GSTA5 CYP2S1 CYP1A1 NAT9 GSTM5 NAA40 NAT10 AKR1B1 NAT14 LOC51064 HS2ST1 SULT1C3 SULT1C2 CYP26B1 CYP4V2 HYAL3 CYP2R1 UGT2A2 UGT2A1 GAL3ST2 GAL3ST3 GAL3ST4 SULT1C4 CHST8 HS3ST3B1 CHST9 CHST6 CHST7 UGT1A1 HEL-S-21 CYP3A43 KCNAB1 HEL-S-22 KCNAB3 BAAT CYP7B1 INMT CYP2A7 CYP2A6 CYP26C1 CYP21A2 UGT2B4 CHST1 CHST4 NAT8L CHST5 UGT2B7 CHST3 HEL-S-75p NAA20 AKR1D1 UGT2B28 CYP7A1 CYP17A1 CYP3A7 SULT1E1 CYP2A13 UGT1A5 UGT1A4 UGT1A3 UGT1A9 CYP2F1 UGT1A7 AKR1C1 CYP51A1 AKR1C2 HS3ST5 AKR1C4 HS3ST6 FMO4 HS3ST4 CYP8B1 FMO5 HS3ST1 HS3ST2 GSTZ1 CYP2W1 CYP24A1 GSTA4 GSTA3 CYP20A1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260910%WP185%HOMO SAPIENS Integrin mediated cell adhesion SELENOP RAPGEF1 ITGA7 ITGA6 ARHGEF7 TLN1 CRK DOCK1 SHC3 ROCK1 ROCK2 SRC PXN CDC42 PAK1 RAP1A RHO PAK6 CSK MAP2K5 PAK4 VASP GIT2 CAV3 CAV2 BRAF CAPN11 CAPN10 ZYX AKT3 MAPK7 MAPK6 MAPK4 SHC1 MAPK12 MAPK10 PIK3R2 MAPK1 RAC1 MAP2K1 MAP2K2 GRB2 SOS1 MAP2K6 MAP2K3 HRAS RAF1 ITGB1 MYLK2 ITGAM ITGB4 ITGB3 ITGA2B ARAF HEL114 ITGAE MYPN CAPN9 CAPN6 CAPN7 CAPN5 ITGAX ITGB8 CAPN3 RAC3 ITGAV ITGB7 ITGB6 TNS1 VAV3 ITGA4 PDPK1 ITGA2 ITGA1 HEL-S-28 FYN VAV2 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260910%WP530%HOMO SAPIENS Cytokines and inflammatory response IL3 IL7 TGFB1 CXCL1 HLA-DRB1 IL10 TNF CXCL2 PDGFA IL2 IL4 CSF3 IL1A CSF2 IFNG IL5 IL12B IL1B CSF1 IL11 IL15 IL13 IL6 IFNB1 FELBAMATE METABOLISM%WIKIPATHWAYS_20260910%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260910%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome DDC IFNA6 AADAT TNF HAAO GOT2 KMO TDO2 KYNU AFMID KYAT3 KYAT1 IDO2 IDO1 IFNG IL1B AHR IL6 IFNB1 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260910%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming ANKRD13C HDAC2 CADM1 IFITM3 IRS1 TET2 PIP4K2A CREBBP HDAC1 NOL9 EZH2 EP300 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260910%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX15 ZSCAN10 TEAD2 SOX4 H4C9 HIST1H4L WWTR1 YES1 SRRT SOX11 SOX12 FGF4 POU3F1 POU3F2 UTF1 SOX2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260910%WP727%HOMO SAPIENS Monoamine transport and regulation ACHE TPH2 TGFB1I1 TNFRSF11B DBH SLC6A2 SLC6A3 HRH3 UNC13B IL1R1 TSC2 FBXO32 SYN1 RBL2 SLC5A7 ADORA2A TH AMPH STX1A NECTIN2 MAPK14 TNF ITGB3 TDO2 IL1B PROLACTIN SIGNALING%WIKIPATHWAYS_20260910%WP2037%HOMO SAPIENS Prolactin signaling CBL RELA NFKB1 SOCS1 FLNA SRC PXN STAT5B PAK1 GAB2 FOS NFKBIA PTPN6 MAPK9 MTOR GSK3B MAPK14 SHC1 PIK3R2 PIK3R1 SOCS3 MAPK1 RAC1 MAPK3 JAK1 CASP3 MAP2K1 MAP2K2 STAT1 STAT3 PTPN11 VAV1 RPS6KB1 GRB2 SOS1 RPS6KA2 JUN HRAS RAF1 HEL-S-130P PRL HEL-S-69p MYC SIRPA ERBB2 NEK3 YWHAG CISH RPS6 PRLR ZAP70 PPIB ITGB1 IRS1 HEL-S-93 AGAP2 SOCS2 EIF4EBP1 PTPN1 TEC NFKBIB MAPK8 FYN VAV2 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260910%WP1533%HOMO SAPIENS Vitamin B12 metabolism F2 HEL-S-78p F7 TCN2 TCN1 CTH RELA NFKB1 ALB SAA1 NFKB2 SAA2 CCL2 IFNG CRP TNF INS SCARB1 SERPINA3 APOB MTRR SAA4 HBB MTR PLAT PLG HEL-S-51e MPO MCEE CBS APOE LDLR ABCA1 FGA IL1B CUBN CCL5 CBLIF INSR HBA2 MAT1A IL6 HEL-S-44 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260910%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis KLF2 CEBPA CEBPB PPARG EGR2 KLF5 CEBPD CEBPG GATA3 GATA2 DDIT3 KLF15 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260910%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence AADAT TNF HAAO FOXO1 KMO TDO2 CDKN1A KLF5 KYNU AFMID IDO2 IDO1 HEL-S-90n IFNG IL1R2 EIF2AK1 EIF2AK4 TLR4 AHR IFNB1 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260910%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP1A2 NAT2 XDH CYP2A6 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA MECR OXSM HTD2 HSD17B12 MCAT METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260910%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts GLS LOXL2 GLUD1 UGDH ADAMTS2 FGFR4 BMP1 ARHA P4HA1 P4HA2 PSAT1 FGFR1 P4HA3 PHGDH PLCG1 CD36 ALDH18A1 PSPH LPAR1 P3H4 PLOD1 P3H3 HEL-S-133P GCK THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260910%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ATF2 FGFR1 SRC PPARG AKT3 MTOR GSK3B MAPK14 MAPK1 CASP9 THRA KDM1A AQP7 TRH TTF2 MAP2K1 TTF1 RPTOR NPPB MC4R BAD RPS6KA6 NHSL1 DUOXA2 MLST8 AgRP SLC16A2 TSHB RPS6KB1 ACTL6B GRB2 SECISBP2L SOS1 DIO1 FRS2 SIRT6 TSC1 SLCO1C1 CREB3 ADRB3 ADCY3 PAX8 TBC1D4 MAPKAPK3 AKT1S1 ZNF516 TSC2 PLIN1 MGLL HRAS PFKFB2 KDM3B RAF1 UCP1 ITPR2 ADCY8 SLC5A5 NR1A2 TPO RXRA MDM2 NPY PRDM16 PPARGC1A DUOX2 FGF21 DEHAL1 RPS6 SLC16A10 MAFA TSHR POMC TG RHEB SLC26A4 FOXO1 PNPLA2 ITGB3 SHH NOTCH1 ITGAV WNT4 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260910%WP3965%HOMO SAPIENS Lipid metabolism pathway ACACA PNPLA2 PRKAB2 PRKAA2 ACSS2 PDHA1 FASN HILPDA PRKAG1 PRKAG2 ABHD5 PLIN1 PRKAB1 PRKAG3 ACLY LIPE PRKAR1B PRKAR1A PRKACG PRKAA1 AKT3 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260910%WP2267%HOMO SAPIENS Synaptic vesicle pathway CPLX2 CLN8 CPLX1 AP2A2 HEL-S-67p RIMS1 CLTCL1 AP2S1 SLC17A6 SLC17A7 SLC17A8 STX2 SLC18A1 UNC13B SLC18A2 AP2M1 SLC18A3 UNC13C SYN1 SLC38A1 UNC13A SYT1 SLC32A1 SYP SYN2 STX1A DNM3 STX1B STX3A SLC25A4 VAMP2 NAPA SNAP25 SLC22A3 STXBP1 CLTC CACNA1B CLTA SLC1A3 CACNA1A AP2A1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260910%WP3945%HOMO SAPIENS TYROBP causal network in microglia GPX1 CD84 NRROS FKBP15 NCF2 PLEK opn LOXL3 GIMAP2 TCIRG1 PPP1R18 CXCL16 LYL1 RGS1 GAL3ST4 CREB3L2 CD37 IL13RA1 RNASE6 HEL-S-66 TNFRSF1B RUNX3 TGFBR1 LGALS9C APBB1IP SLC7A7 MAF TYROBP BIN2 ELF4 NPC2 DPYD HCLS1 SFT2D2 RBM47 IGSF6 PYCARD KCNE3 SAMSN1 ZFP36L2 HLX CYTL1 NCKAP1L SH2B3 IL10RA HEL-S-62p LHFPL2 RPS6KA1 CENTA2 GAPT IL18 C1QC ITGAM ITGAX OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260910%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development HNF1A RUNX2 DMP1 NOTCH2 KLF4 NOTCH3 DKK1 NOTCH1 DSPP ALPL NOTCH4 SP7 SOST BMP7 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 SC5D DHCR24 DHCR7 LBR QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260910%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis NFKB1 IKBKB JUN PTGS2 FOS NFKBIA KEAP1 NFE2L2 MAFG CYP2A6 MAFK COX1 VEGFA BREAST CANCER PATHWAY%WIKIPATHWAYS_20260910%WP4262%HOMO SAPIENS Breast cancer pathway FZD9 FZD8 FGF18 SHC3 FGF10 FGFR1 WNT2B PIK3CD HEY2 FOS WNT16 LRP5 BRAF DLL3 DLL4 WNT7B AXIN2 RB1 CDKN1A KIT NBN DDB2 GADD45B GADD45A JUN MRE11A GADD45G RAD50 RAF1 CDK6 RAD51 CDK4 CCND1 EGF BAX IGF1R MYC FRAT1 ERBB2 FRAT2 TNFSF11 PGR ATM SKP1 CSNK2A1 ATR CSNK2A3 CSNK2A2 SFRP4 NR3A2 FGF2 CSNK2B SHC4 SHC2 DVL1 DVL2 FGF20 DVL3 FGF23 FGF22 FGF17 FGF16 SP1 FGF19 FLT4 CETN3 PTEN IGF1 BRCA2 POLK APC2 AXIN1 SOS2 LEF1 EGFR E2F2 HES1 E2F3 BAK1 HES5 TCF7L2 TCF7L1 CSNK1A1 APC RPS6KB2 CSNK1A1L NFKB2 FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 AKT3 MTOR GSK3B SHC1 PIK3R2 PIK3R1 MAPK1 MAPK3 NCOA1 MAP2K1 MAP2K2 RPS6KB1 GRB2 SOS1 NRAS HRAS FZD10 FGF3 FGF4 FGF6 FGF7 FGF21 FGF8 FGF9 WNT5B ARAF NOTCH2 NOTCH3 NOTCH1 NOTCH4 PIK3R3 WNT1 WNT4 JAG2 WNT10B WNT10A FZD2 FZD5 FZD7 ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP241%HOMO SAPIENS One carbon metabolism TCN2 MTFMT AHCYL2 HEL-S-70p SHMT1 HEL-S-61p AMT MTRR GLRX MTHFS TYMS MTR FTCD DHFR FOLH1 HEL-S-51e MTHFD1L MTHFD1 MTHFD2 CHDH DNMT3B MAT1A INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260910%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL17F TGFB1 IL2RG IL10 NFKB1 IL18 JUN GATA3 IL2 IL4 IL1A IFNG IL12A TLR4 IL22 IL23R RORC RORA NOD2 IL-21 HLA-DMA IL18RAP IL13 TBX21 STAT4 IL21R IL12RB1 SMAD2 IFNGR1 TNF NFATC1 FOXP3 IL23A TLR5 IL5 MAF STAT1 STAT3 IL6 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260910%WP710%HOMO SAPIENS DNA damage response only ATM dependent TCF7L2 TCF7L1 TGFB1 APC NFKB1 NFKB2 WNT2B PIK3CD PIK3C2G CDC42 PIK3C2B WNT16 WNT3A WNT7A WNT3 MAPK9 AKT3 WNT7B GSK3B SHC1 MAPK10 ARHA PIK3R2 PIK3R1 PPP2R5E CDKN1A FOXO3A CDKN1B PPP2R5C MAPK1 RAC1 BCL2L11 BBC3 MAP3K7 PCK2 MLKL BIK CDKN2A CCND3 G6PC1 CCND2 TNFSF6 BCL6 CCNG2 TP73 BAD GRB2 SOS1 PMAIP1 JUN HMGB1 MAP3K1 NRAS HRAS BCL2 RBL2 FOSL1 CCND1 MDM2 BAX MYC FRAT1 ERBB2 ATM IRS1 WNT5B DVL1 DVL2 DVL3 PIK3R4 PIK3R3 PTEN PIK3R5 RAC3 WNT1 WNT4 AXIN1 LDLR WNT10B SOS2 LEF1 WNT10A SMAD4 INSR MAPK8 BAK1 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260910%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation FOXO1 PDGFA INS MAPK1 TGFBR1 MAPK3 IGF1 CDK4 CRTC2 FLT1 CDK2 PDX1 BRAF FOXM1 IGF1R RAB43 MYC RASSF1 INSR AKT3 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260910%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX CYP4A22 PLA2G5 PLA2G6 NR1C2 TBXA2R PTGES PTGDR CYP4F2 PTGIR PLA2G4B CYP4A11 PTGR1 CYP4F12 ACOX1 PTGS2 EHHADH ACOX3 PTGS1 PTGIS PRXL2B PPARG AKR1B1 PTGFR HEL-S-298 HPGD PTGDR2 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260910%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 TTC19 CYB UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCC UQCRC2 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260910%WP2249%HOMO SAPIENS Metastatic brain tumor CDK6 PIK3R1 MYC CDC42 E2F3 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260910%WP4236%HOMO SAPIENS Krebs cycle disorders SUCLG2 HEL-S-281 SUCLG1 GPT DHTKD1 PDHX FH PCK2 SUCLA2 MPC1 HEL-S-133P MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260910%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COMP MATN1 COL9A1 COL9A3 COL9A2 MATN3 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260910%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways NEIL2 RAD51C MSH2 MSH3 PNKP XPA FAAP24 XPC UNG RAD54B POLD3 POLD4 BRIP1 WRN NTHL1 RAP1A TDG POLD2 USP1 PMS2 NHEJ1 MUTYH GTF2H2C_2 MBD4 FANCM CENPX FANCL POLM FANCA RPA1 APEX2 GTF2H2 FANCB GTF2H3 FANCE GTF2H4 PALB2 GTF2H5 FANCG FANCF POLE4 SMUG1 H2AX CUL4A CDK7 POLE2 RPA3 APEX1 ERCC1 POLE3 ERCC2 ERCC5 MNAT1 CENPS CUL4B CHEK1 NBN RFC1 DDB2 FANCD2 MRE11A HMGB1 RAD52 RAD50 RAD51 ATM ATR FEN1 WDR48 CCNH MPG PRKDC OGG1 CETN2 PCNA REV3L POLI XRCC5 POLL BRCA2 POLE POLK RFC3 RFC4 LIG1 RFC2 PARP2 REV1 TERF2 RBX1 MSH6 DDB1 NEIL3 FAN1 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260910%WP4814%HOMO SAPIENS Somatic sex determination SOX8 SOX9 DMRT1 WNT4 DHH GATA4 FOXL2 NR5A1 WT1 SRY AMH RSPO1 FGF9 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260910%WP45%HOMO SAPIENS G1 to S cell cycle control RPA1 RB1 CDKN1A CDK7 CDKN1B POLE2 RPA3 CDKN2A CCND3 CCND2 MNAT1 CCNG2 CDKN1C MCM7 ORC1L CREB1 CREB3L3 CCNE2 CREB3L4 TFDP1 TFDP2 CCNE1 MCM3 MCM5 MCM6 CCNB1 PRIM2 CREB3 ATF6B PRIM1 CDC45 ORC6 GADD45A ORC3 ORC2 CDKN2D CDKN2B CDC2 CDKN2C WEE1 POLA2 CDK6 CDK4 CDK2 CCND1 MDM2 MYC ATM CCNH PCNA POLE MYT1 E2F2 MCM2 E2F3 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260910%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome TGFB1 PXN STAT5B NRROS JUN HEL-S-71 SIRT1 TFRC CEP19 HFE SLC40A1 PIGX DYNC2H1 DYNC2I2 H2BC21 MYC UBXN7 SMCO1 DYNLT1 NCBP1 NCBP2 DYNLT3 FBXW7 DYNLT2B ADAM10 SLC51A DYNLL2 SLC51B FNDC8 DYNC2LI1 RNF168 PIGM MFI2 MYCBP2 RNF8 FBXO45 HIF1A DYNLRB2 ZDHHC19 DNCL1 BRINP1 TM4SF19 CEP350 MCRS1 RABL2B MAD2L1BP PIK3R3 WDR53 ZNF76 TF NF2 HAMP MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma GRB2 RAPGEF1 SOS1 CBL CRK SRC JAK3 JUN PIK3CD CDC42 NRAS PAK1 RAP1A HRAS PAK6 RAF1 PAK4 BRAF HGF KDR AKT3 PIK3R2 PIK3R1 ARAF CDKN1A MAPK1 RAC1 PLCG1 MAPK3 PIK3R3 MAP2K1 ALK MAP2K2 PRCC RPL11 BAD SOS2 CRKL STAT3 ELOA PTPN11 INSL3 C8orf34 MAPK8 STRN VEGFA SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260910%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 CYP4F3 FADS2 ACSL1 ALOX5 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP560%HOMO SAPIENS TGF beta receptor signaling ZFYVE9 SMAD9 TGIF1 TGFB1 LEFTY1 FST NOG FOXH1 NFKB1 TGFBR2 TGFBR3 ZEB2 ENG EP300 LTBP1 THBS1 ZNF423 LEFTY2 INHBA SMAD6 FOS FKBP1A DKFZp781O1323 SKI BAMBI MAPK9 opn SMAD2 RUNX3 SKIL TGFBR1 MAPK3 JAK1 CREBBP STAT1 STAT3 JUN HRAS IFNG EGF TNF RUNX2 LIF WNT1 ITGB6 BMP4 SMAD1 LEF1 SMAD4 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260910%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 SEL1L APOA2 LPL APOA4 APOA5 LDLR LMF1 LIPC APOC2 ANGPTL8 ANGPTL3 ANGPTL4 PLTP GPIHBP1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260910%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 RRM2B ADSL RRM2 NME2 OAZ1 SRM POLA1 IMPDH1 ADSS POLG DHFR MTHFD2 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260910%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects FZD9 FZD8 WNT2B PIK3CD WNT16 LRP5 BRAF MAPK9 WNT7B MAPK10 CASP9 CASP3 APAF1 CDK5 CYCS ADAM10 IRS1 INS CHRNA7 APOE INSR NFKB1 LPL APP CALML6 CALML3 CALML4 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 ATG14 DKK2 DKK4 VDAC3 ULK2 ULK1 CSF1 ATF4 PPP3R1 APH1B PPP3R2 NRBF2 XBP1 EIF2AK2 GRIN2B ATG2A NOX4 CALM1 ATG2B RYR3 hCG_2014051 TUBA1C PPP3CA TUBA1B PTGS2 CASP12 TUBA1A PPP3CC NRAS PSENEN HRAS MME TUBB BACE1 PLCB3 ITPR2 PLCB4 TUBB2A PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PSMA8 PSMB6 TUBA3E PSMB2 PSMB3 TUBB4B TUBB4A GRIN1 PSMC6 PSMC4 PSMC1 CDK5R1 HEL-S-276 IRS4 TUBB8 TUBB6 KIF5A TUBB1 MAP3K5 HEL-S-61 CYBB TUBA4A ERN1 ADAM17 PPIF RTN3 PSMD12 PSMD13 PSEN2 GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 HEL-S-162eP NAE1 CACNA1S SHFM1 EIF2S1 RELA TUBA2 IKBKB TUBA8 ATP2A2 ATP2A1 RB1CC1 TRAF2 WIPI1 WIPI2 CHUK SLC25A5 SLC25A6 TUBAL3 HEL-S-91n BECN2 AMBRA1 SNCA NOS2 ADRM1 SLC25A31 SLC25A4 AXIN2 HSD17B10 DKK1 DDIT3 RAF1 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B TNF DVL1 DVL2 DVL3 APC2 AXIN1 IL1B MAPK8 CASP8 FADD CSNK1A1 APC TNFRSF1A CSNK1A1L FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 AKT3 MTOR GSK3B PIK3R2 PIK3R1 MAPK1 MAPK3 MAP2K1 MAP2K2 BAD IL6 IL1A FZD10 WNT5B ARAF PIK3R4 PIK3R3 WNT1 WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2877%HOMO SAPIENS Vitamin D receptor pathway CEBPA LRP5 STEAP4 LPGAT1 CCNC GXYLT2 CLDN2 SLC8A1 STS SALL4 LGALS9 EPHB4 KRT71 HLA-DRB1 IGFBP1 SLC34A2 HNF1A S100A2 TPM1 MED9 CDKAL1 LCE1F SFRP1 LCE1D CDKN1A LCE2B CDKN1B CDC34 NINJ1 S100A6 S100A4 S100A9 S100A8 TNLG2B ABCB1 COL13A1 CLEC16A ADRB2 EFNA5 KNG1 KLK6 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 CD14 HLA-DQA2 HLA-DQA1 CCNE1 KL CYP3A4 SLC37A2 KRTAP12-2 KRTAP8-1 NFATC2 TNFRSF11B BMP6 TRPV6 TRPV5 GADD45A ID1 PNOC KLF4 ID4 ALPI CDKN2D CLPTM1L CDKN2B MXD1 CDKN2C ALPG ZNF257 SPRR1B CD200 ORM1 CD40 IL25 CDK2 TNFAIP3 CCND1 SLC2A4 ADRA1B MYC ORM2 TREM1 THBD TNFSF11 ADAMTS5 CASP14 SULT2A1 DUSP10 ADGRE5 CASP5 DNER DACT2 TIMP3 SOSTDC1 FOXO1 BDKRB1 KRTAP5-1 CA9 HIF1A ABCD1 CAMP FGF23 KRTAP5-4 KRT34 CEACAM1 KRT38 IRF4 IRF8 DEFB4B CYP27B1 COLEC11 CYP2B6 SATB1 PTH HEL57 CBS SEMA3B ASAP2 TRAK1 CST6 PTHLH IL1RL1 CST1 CLMN BGLAP CREG2 HSD17B2 LRRC25 TGFB1 S100G KRTAP10-2 KRTAP10-4 CDX2 KRTAP10-7 NR1i1 MX2 KRTAP10-9 KRT13 G0S2 MYO9B CYP2C9 ATP2B1 CTLA4 DEFB132 KRT16 CD9 CYP2S1 CYP1A1 SULT1C2 opn JUNB CDKN2A BCL6 PTGER4 NR1C2 CYP7A1 ALOX5 IGFBP5 IL12A RXRA CYP24A1 ITGAM PRKCQ HILPDA CELL CYCLE%WIKIPATHWAYS_20260910%WP179%HOMO SAPIENS Cell cycle EP300 RB1 CDK7 CDKN1A CDKN1B CCND3 HDAC2 CCND2 CHEK2 CHEK1 CDKN1C SMC1A MCM7 ORC1L CCNE2 TFDP1 CCNE1 TFDP2 CCNB3 MCM3 CCNB2 MCM5 CCNB1 MCM6 SFN GADD45B CDC45 ORC6 GADD45A ORC3 ORC2 CDKN2D CDC2 CDKN2B GADD45G CDKN2C WEE1 RBL2 CDK6 CDK4 CDK2 CCND1 MDM2 MYC ATM YWHAG SKP1 ATR HEL-S-93 E2F2 E2F3 TGFB1 HEL2 SMC3 CDC14B CDC20 CDC23 PTTG1 PTTG2 CDC27 SKP2 ANAPC7 CDC25B ANAPC5 MAD1L1 ANAPC1 ANAPC2 ANAPC13 PKMYT1 ANAPC10 ANAPC11 SMAD2 GSK3B RAD21 PLK1 HDAC1 CDC6 STAG1 STAG2 YWHAQ HEL-S-1 SMC1B CCNA2 RBL1 DBF4 ESPL1 TTK CDKN2A FZR1 E2F4 E2F5 MAD2L2 WEE2 CCNH PRKDC PCNA SMAD4 RBX1 MCM2 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260910%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling HRAS MAPK3 RAF1 MAP2K1 MAP2K2 RASGRF1 MAPKAPK2 GATA4 HTR2B HTR2A MAPK1 NRAS VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260910%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ATP2B4 ATP2B3 ATP2B2 GRIN2B KCNQ2 KCNQ3 TPH2 PVALB NR1i1 ATP2B1 HEL-75 BCL2 GCLC ITPR2 RXRA SLC8A1 GRIN1 CYP27A1 KDM1A CYP27B1 NFE2L2 CACNA1C TPH1 KDM3A CHRM1 KDM1B CALB1 KDM6B FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260910%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP1A2 CYP3A4 ADH1C HEL-S-117 CYP2E1 ADH1A CYP4A11 ADH7 ALDH2 HEL-S-53e HEL-S-4 CYP1A1 CYP2A6 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260910%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CRP TNF CCL11 PBR CCL2 GRN GFAP CCL23 BDNF DBI ADM S100B CX3CL1 OLR1 CHI3L1 NEFL IL1B TREM1 CCL5 IL6 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260910%WP4155%HOMO SAPIENS Endometrial cancer TCF7L2 TCF7L1 APC FGFR3 FGFR2 FGFR1 PIK3CD FOS BRAF AKT3 GSK3B AXIN2 PIK3R2 PIK3R1 CDKN1A FOXO3A MAPK1 CASP9 MAPK3 MAP2K1 MAP2K2 BAD DDB2 GRB2 SOS1 GADD45B GADD45A NRAS GADD45G HRAS RAF1 CCND1 CTNNA1 CTNNA3 EGF BAX MYC CTNNA2 ERBB2 FGF2 ARAF PIK3R3 PTEN POLK APC2 AXIN1 SOS2 LEF1 EGFR PDPK1 HEL-S-28 BAK1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260910%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IFIT1 PSMB8 IFIT3 PIAS1 IFITM1 IFNGR1 IRF9 IFNAR1 IRF-1 SOCS1 IFNG JAK1 STAT1 IFNAR2 TYK2 STAT2 IFNGR2 MX1 IFI35 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260910%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCD4 INPP5D PIK3CD PIK3C2G PIK3C2B PLCB3 PLCB4 PLCB1 PLCB2 MTMR1 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 PLCG1 MTMR4 STM7 MTMR6 PIK3R4 MTM1 MTMR10 PIP4P2 PIP4P1 PTEN PLCG2 PIP4K2A PIP5K1A PLCE1 PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE PLCH1 PLCH2 PLCD3 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260910%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition CDH6 CDH2 SMAD2 SNAI1 SNAI2 CDH16 RUNX2 ID1 MAPK1 MAPK3 TNC SMAD4 HEL113 AKT3 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260910%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MIPEP UFD1L UBXN1 CLPB MICOS13 PARK2 TXN2 OPA1 AIFM1 C1QBP OPA3 GDAP1L1 SACS LONP1 PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP TMEM126A YME1L1 MICU1 VCP PLEK HTRA2 SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 MFN2 MCL1 MARCHF5 DNAJC19 TIMM8A TIMMDC1 TXNRD2 AGK USP9X PYCR2 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 STAT2 TRAK1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260910%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGN GPAA1 PGAP3 PIGP PIGW PIGM PIGV PIGY PIGC DPM2 PIGB PIGA PIGK MPPE1 PIGL PIGF PIGH PIGX PIGS PIGU PIGT PGAP1 PIGO PGAP2 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260910%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway TGFB1 DDR1 NQO1 SUV39H1 LOXL4 SIRT1 NRF1 ECSIT PKD1 NFE2L2 COL2A1 BMP2 CDC37 EXOC6 IGFBP7 HEL-S-7 FGF7 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260910%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface KIR2DL4 FCGR3A TGFB1 KLRK1 SMAD2 NCAM1 CXCL8 FOXP3 TGFBR2 ITGAE IL2RA TGFBR1 CD9 IFNG SMAD4 ANGPT2 ANGPT1 ITGA1 SMURF2 VEGFC CD14 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260910%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups GLUD1 ARG2 ARG1 SRM HEL-S-20 HEL-S-29 ASS1 SMS ASL NAGS HEL-S-5 OTC ALDH18A1 FOLATE METABOLISM%WIKIPATHWAYS_20260910%WP176%HOMO SAPIENS Folate metabolism F2 HEL-S-78p F7 CTH RELA NFKB1 ALB SAA1 GPX2 NFKB2 SAA2 GPX1 SHMT1 GPX4 GPX3 CCL2 MTHFS DHFR MTHFD1 MTHFD2 CRP CSF1 IL6 IL2 IL4 IFNG TNF INS SCARB1 SERPINA3 APOB MTRR SAA4 SLC46A1 HBB MTR FLAD1 PLAT GPX6 IZUMO1R PLG HEL-S-51e SLC19A1 MPO FOLR3 FOLR2 CBS FOLR1 LDLR ABCA1 FGA IL1B INSR HBA2 MAT1A HEL-S-44 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260910%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF3E EIF3F EIF3D EIF3A EIF3B EIF2S1 EIF1AX EIF2S2 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders HPD GSTZ1 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260910%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells TGFB1 SELPLG VCAM1 SELE SELP CD40LG PF4 CCL2 TLR7 CD40 TLR4 IL1B CCL5 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260910%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway MAP2K6 MAP2K3 MAPKAPK3 GNAI3 GNAI1 MAP3K1 RPS6KA5 HTR1E RAP1A HTR1F HTR1D FOS HTR1A HTR1B GNAO1 BRAF MAPK14 ARHA MAPK1 MAPK3 MAP2K1 RASGRF1 MAP2K2 MAPKAPK2 HTR2A STAT3 PDPK1 CREB1 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260910%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRF7 ATF2 IRAK4 RELA NFKB1 IKBKB EIF4E MAP2K6 MAP2K3 TRAF6 MAP3K1 RPS6KA5 IL1R1 CHUK FOS IL1A NFKBIA TANK IRAK1 IRAK2 MAP3K8 SAFB MAP3K7IP1 MYC TAB3 MAP3K14 MAPK9 MYD88 MAPK14 MAPK10 MAPK11 MBP NFKBIB MAPK1 MAP3K7 MAPK3 MAP2K4 MAP2K1 MAP2K2 MAPKAPK2 MAPK8 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260910%WP4157%HOMO SAPIENS GABA metabolism aka GHB HEL-S-166mP ADHFE1 GLS GAD1 GAD2 ABAT PON3 ALDH5A1 GLS2 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma JAK1 IL6ST SOX4 IL11RA NFKB1 RELA STAT3 JAK3 IL11 IL6 IL6R CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260910%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260910%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP23B SCN8A MMP17 MMP19 HEL-S-62p BDNF NOS2 MMP2 PRKCI MMP9 PRKCH PRKCB PRKCE PRKCA PRKCQ SLC2A3 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 PRKCZ SCN9A MMP7 TRPA1 MMP3 SORD SNAP25 TRPV1 MMP10 MMP12 MMP11 SCN10A AGER MMP14 MMP16 PRKD3 MMP15 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260910%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260910%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A NAD METABOLISM%WIKIPATHWAYS_20260910%WP3644%HOMO SAPIENS NAD metabolism NRK SIRT6 SIRT4 SIRT5 NMNAT3 NMNAT2 SIRT7 SIRT2 SIRT3 NMNAT1 NAMPT NADK NT5E SIRT1 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260910%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling ITGA7 FGF18 ITGA6 FGFR4 FGFR3 FGFR2 FGF10 FGFR1 PIK3CD PIK3C2B IFNB1 CDKN1A CDKN1B CASP9 CREB1 CREB3L3 CREB3L4 ATF6B TSC2 COL2A1 CDC37 MDM2 PRL ANGPT2 ANGPT1 VEGFC RPS6 PRLR FOXA1 IRS1 ACACA FOXO1 EIF4EBP1 INS HIF1A INSR IL2RG THBS1 IL2RA IL2RB CSF3 HGF LPAR1 opn PDGFA SLC2A3 RPTOR ULK1 CSF1 ATF4 MLST8 VEGFA TSC1 CREB3 AKT1S1 NRAS HEL-S-125m TCL1B HRAS PFKFB2 TCL1A PPP2R1B PPP2R1A KPG_010 PELO DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 PPARGC1A PDGFD PDGFC FGF21 NGFR GNG12 GNG11 GNG13 COL1A1 COL1A2 IFNA7 RHEB HIF3A GNGT1 GYS2 GYS1 IRS4 PRKAA2 GNGT2 IKBKG RAB8A STRADA OSMR PHLPP2 PHLPP1 CAB39 COL11A2 LIPE PPP2CA RELN VEGFB OSM VEGFD XB CSHL1 RAB11B COL3A1 KITLG GHB3 CHRM2 PRKAA1 CSF3R STK11 IBSP TNR RAB2A PDGFRA ATF2 F2R COL4A2 COL4A1 IKBKB EIF4E1B COL4A4 COL4A6 PFKFB1 JAK3 CSF1R PFKFB4 EFNA4 VTN CHAD EFNA1 EFNA3 FGF14 EFNA2 COL5A3 EPO GNB2 NOS2 TNC COL5A2 GNB1 GNB4 GNB3 IL7R FGF13 KDR FGF12 HSP90AB1 SLC2A2 LAMC2 LAMC1 ELAVL1 GHR VWF PPP2R5B PPP2R5A PPP2R5D NGF CREB3L2 IL3RA CREB5 LAMA5 KIT LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 GNG3 GNG2 GNG5 GNG4 PPP2R3C GNG7 EFNA5 GNG8 EIF4B ANGPT4 LAMB3 LAMB2 LAMB1 PPP2R3A EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PPP2R2B PPP2R2D EIF4E RAF1 SLC2A4 EGF IGF1R FGF2 FGF20 FGF22 FGF17 FGF16 FGF19 FLT4 PTEN IGF1 EGFR RPS6KB2 AKT3 MTOR GSK3B PIK3R2 PIK3R1 PPP2R5E FOXO3A PPP2R5C MAPK1 IL6R MAPK3 JAK1 MAP2K1 CRTC2 MAP2K2 FLT1 BAD CHRM1 RPS6KB1 GRB2 SOS1 IL2 FGF3 FGF4 IFNAR2 FGF6 FGF7 FGF8 FGF9 ITGB1 COMP IFNAR1 ITGAM ITGB4 ITGB3 ITGA2B ITGAE PIK3R4 ITGAX ITGB8 PIK3R5 ITGAV ITGB7 ITGB6 ITGA4 PDPK1 ITGA2 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260910%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer SOS1 SHC1 KSR1 GAREM2 JUN FOS MAPK3 RAF1 MAP2K1 ALK MAP2K2 SOS2 BRAF MYC INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260910%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases BDNF BACE1 CEBPB SNCA SRPK2 STAT1 NTRK2 SET APP TARDBP AKT3 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260910%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway SRM SMS HEL-S-61p AMD1 APIP MRI1 TXN MTR IL4I1 MSRA MTAP ADI1 MSRB2 MSRB3 CHDH ENOPH1 MAT1A CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260910%WP3594%HOMO SAPIENS Circadian rhythm genes EP300 ROCK2 NOS2 PPARG MAPK9 DDC MAPK10 HDAC2 EZH2 CREB1 TCF2 TPH2 JUN ID4 PML SUV39H1 ADORA2A TH CDK4 C1orf51 CRTC1 NPY2R PRF1 UBE3A RORB CCAR2 PPP1CC GIG8 SKP1 HTR7 PROK2 HEL-S-80p BTRC PROK1 CHRNB2 MTTP UTS2R CPT1A FBXW11 KCNH7 USP2 METTL3 DYRK1A SOX14 CSNK1D CARTPT SLC9A3 MTNR1A CLDN4 MTNR1B PSPC1 PTEN TIMELESS UTS2 SIK1 ATF5 DDX5 MAGEL2 KMT2A MAGED1 BHLHB2 CREM MAPK8 TNFRSF11A NPAS2 RAI1 AANAT UBC F7 NKX2-1 DRD1 DRD2 DRD3 DRD4 EGR1 ZFHX3 OPN4 JUND OPN3 HOMER1 NONO TYMS GFPT1 NR1D2 NR1D1 BTBD9 SETX STAR HNRNPD ID3 FBXL3 OGT RORC ADA PROX1 RORA TOP2A KDM5A SUV39H2 SFTPC BHLHE41 NR1C1 HEBP1 RBM4 DBP SIN3A GSK3B SIX3 HEL-S-2 KLF10 HDAC1 KCND2 PAX4 MC3R SFPQ NCOR1 THRAP3 CRY2 KCNMA1 CRY1 CRH AVP NLGN1 HDAC3 CIPC CRX RBM4B ADCY1 RELB NPS ATOH7 TPH1 PROKR1 ATF4 NFIL3 CHRM1 AHR GNA11 AgRP NR2F6 NOCT IL6 RPS27A NTRK1 ARNT2 NTRK3 CAVIN3 NR1H3 PASD1 HCRTR2 HCRTR1 PER2 hCG_2014051 PER1 PER3 MYBBP1A GHRH LEP NAMPT KLF9 GHRL BMAL2 SIRT1 PPARGC1A HS3ST2 NGFR PRKAA2 PRKDC PHLPP1 PRKAA1 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP5094%HOMO SAPIENS Orexin receptor pathway BMPR1A DKFZp781O1323 STAR MAPK9 MAPK7 MTOR MAPK14 PIK3R2 PIK3R1 MAPK1 CASP9 MAPK3 BMP7 CASP3 MAP2K1 MAP2K2 NFE2L2 EIF4B STAT3 PTPN11 GNA11 CREB1 IL6 RPS6KB1 NOX4 IL10 HCRTR2 CXCL8 HCRTR1 RPS6KA1 GNAI1 LEP GHRL IL4 NPFFR1 DAGLA DKFZp686L0365 FSHB SGK1 TH LHB SLC1A2 CAMKK2 GNAS SLC2A4 NPVF NPY VHL CGA DYNLT1 HCRT OPRK1 DYNLT3 GCG CCK RPS6 GH1 IL9 GNRH1 POMC PRKCB TNF PRKCE CXCL2 PRKCA FOXO1 EIF4EBP1 RUNX2 HIF1A PRKD1 PRKCZ SMAD1 IL1B PDPK1 PRKAA1 MAPK8 BGLAP EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260910%WP5443%HOMO SAPIENS Effects of MFN2 mutation RAB3B DCTN1 ATAT1 DYNC1LI2 RHOT1 SYPL1 MAP2 MFN2 KIF1B RABAC1 RAB7A DYNC1I1 CASP3 SNCA DYNC2H1 TRAK1 DYNC2I2 BAX DYNC1H1 CASP8 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260910%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR RELA NFATC2 NFKB1 PPP3CA EP300 PPP3CC NFKBIA HDAC1 NFATC1 HDAC5 SUPT4H1 HDAC8 HDAC7 NELFB SP1 NELFCD HDAC2 NELFA HDAC3 NELFE HEXIM1 NFATC3 CREBBP SUPT5H NFATC4 CDK9 PPP3R1 PPP3R2 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260910%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TSHR TG PRKCA NFKB1 PRKAA2 MAPK1 HEL-S-5 RAP1A MAPK3 RAF1 TRH MAP2K1 SLC5A5 MAP2K2 TPO DUOX1 CLCN5 CGA DUOX2 PRKAA1 CREB1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260910%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV FMR1 CAMK2A NRXN3 GRIN2B NRXN2 RPH3A SYNGAP1 DLGAP1 CAMK2G TJP1 ARC DLG2 SHANK1 HOMER1 STX1A YWHAG GRIN1 MAPK1 MAPK3 NLGN1 NLGN3 CYFIP1 RYR2 CAMK2D NLGN2 NRXN1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260910%WP5089%HOMO SAPIENS Kinin Kallikrein pathway BDKRB1 KNG1 BDKRB2 SERPING1 KLKB1 CPN1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2881%HOMO SAPIENS Estrogen receptor pathway GPAM CYP1A2 PDK4 PCK1 NR0B2 CYP1A1 STAT3 ACOX1 JUN CYP1B1 NR1C1 SP1 SARS COV 2 ENVELOPE LIPID COMPOSITION AND HUMAN CELL BINDING%WIKIPATHWAYS_20260910%WP5255%HOMO SAPIENS SARS CoV 2 envelope lipid composition and human cell binding AXL CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260910%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism CYP17A1 CYP11B2 STAR H6PD HSD3B2 SRD5A2 CYP11A1 HSD3B1 HSD17B3 HSD11B1 CYP21A2 HSD11B2 POR OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260910%WP5574%HOMO SAPIENS Oligodendrocyte development TCF7L2 PDGFRA NFATC2 ZEB2 EGR2 ID4 MYRF CHD8 GIG8 PTN ZNF24 DUSP15 NKX6-1 ASCL1 ZNF488 FGF2 LGI1 OPALIN BMP1 PRKCA ZBTB33 SHH TMEM98 MBP NFIA SOX8 CNTN1 SOX9 CSPG4 SOX6 SOX5 NKX2-2 NKX2-6 OLIG1 RELN OLIG2 SOX10 MYT1 BMP4 SMAD1 WNT10A SOX11 SOX2 HES5 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260910%WP661%HOMO SAPIENS Glucose homeostasis INS GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260910%WP2363%HOMO SAPIENS Gastric cancer network 2 LBR TOP2A MYC RAD17 COL9A1 COL9A3 OTUD5 DGIC AHCTF1 DSCC1 S100A6 CHTF18 LMNB2 MTDH CHTF8 BRIX1 UBE2C RFC3 ATAD2 RFC4 CACYBP FAM91A1 RNF144B UBE2T EGFR SNURF CD48 CEBPZ ESTROGEN SIGNALING%WIKIPATHWAYS_20260910%WP712%HOMO SAPIENS Estrogen signaling MAPK14 NFKB1 GNGT1 IKBKB IKBKG JUN MAPK1 CHUK SP1 FOS BCL2 MAP2K1 GNB1 GNAS BRAF MAPK9 GPER CREB1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260910%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance ABCB1 BCL2L1 HIF1A CDKN1A BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260910%WP3927%HOMO SAPIENS BMP signaling in eyelid development INHBB PITX2 FGFR2 SHH TGFA FGF10 SFRP1 JUN MAP3K1 NOTCH1 MAPK3 DKFZp781O1323 DKK2 BMP4 SMAD1 SMAD4 EGFR MAPK9 FOXC2 FOXC1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades F2 HEL-S-78p F7 F2R SERPING1 KLKB1 SERPINA1 APOA2 VWF KNG1 PROS1 CLU C8G C3AR1 HEL-S-62p CR2 CR1 SERPINF2 PLAUR C1QC F3 F5 F8 F9 MASP2 MASP1 CD46 CFB CFD C1QB C1QA CPB2 C1S CFH SERPINC1 CFI C5AR1 C4B_2 THBD TFPI LMAN1 C6 C7 C9 CD55 F10 SERPIND1 PROC F13B BDKRB1 PLAT PLG CLTC NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260910%WP4220%HOMO SAPIENS Neurotransmitter disorders DDC TH TPH2 PNMT MAOA DBH TPH1 SLC6A3 SLC18A2 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260910%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC3 UGT2B7 ABCC2 CYP3A4 ABCB1 UGT1A10 SLCO1B1 UGT1A8 UGT2B4 UGT1A3 UGT1A1 UGT1A9 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260910%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders PIGV HEL-S-302 PLPBP HEL-S-1a ALDH7A1 ALPI ALPL WNT SIGNALING NETPATH%WIKIPATHWAYS_20260910%WP363%HOMO SAPIENS Wnt signaling NetPath TCF7L2 CSNK1A1 APC TSC1 NFATC2 hCG_2014051 TSC2 DKFZp686L0365 CDK6 PPARG LRP5 CCND1 FRAT1 LRP6 MAPK9 MTOR GSK3B PRKCB PRKCA ARHA DVL1 DVL2 NLK DVL3 MAPK1 RAC1 GSK3A MAP3K7 CSNK1D CTBP1 STM7 SOX1 GCKR RYK BCL9 TCF4 ROR1 ROR2 TCF3 AXIN1 PI4K2A CSNK1G1 LEF1 MAPK8 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260910%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 IL10 STAT3 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260910%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway CEPT1 CDIPT CHKB PCYT2 IPMK PLA2G2A CRLS1 GNPAT GPD1 PEMT CHPT1 LPIN1 PIK3CD LPIN2 CDS2 GPAM PIP5K1A PI4K2A MOGAT3 PGS1 HMFN0839 PTDSS1 GPAT4 PTPMT1 GPAT2 PPAR SIGNALING%WIKIPATHWAYS_20260910%WP3942%HOMO SAPIENS PPAR signaling UBC NR1C2 NR1H3 CYP7A1 CYP4A11 ACOX1 EHHADH SLC27A1 PLIN1 RXRB CPT2 DBI ME1 UCP1 PCK1 RXRG HEL-S-104 APOA2 APOC3 LPL OLR1 CPT1C FABP1 PPARG APOA5 SCD RXRA SLC27A4 CYP8B1 ANGPTL4 NR1C1 PLTP CYP27A1 CD36 PCK2 SLC27A5 AQP7 PDPK1 FADS2 HEL-S-28 ACSL1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260910%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation GRK1 FPR2 EPHB2 PIK3CD LTB4R CMKLR1 MTOR ID SIGNALING%WIKIPATHWAYS_20260910%WP53%HOMO SAPIENS ID signaling CCNE1 PAX2 RB1 PAX8 ID1 RBL1 RBL2 MYOD1 ID3 CDK2 PAX5 GIG8 ELK3 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260910%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia TNFRSF1A RELA NFKB1 IKBKB NFKB2 EP300 AKT1S1 IL1R1 CHUK FBXO32 IL1A NFKBIA IGF1R MTOR MSTN MAP1LC3A TRIM63 SMAD2 TNFRSF12A CEBPB TNFSF12 TNF ACVR2A REL MAPK11 FOXO3A IKBKG IL6R JAK1 IGF1 RPTOR RELB STAT3 IL1B SMAD4 MLST8 IL6 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260910%WP550%HOMO SAPIENS Biogenic amine synthesis GAD1 AANAT GAD2 DDC ACHE PNMT MAOA HDC ASMT DBH PAH ChAT TH TPH1 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP138%HOMO SAPIENS Androgen receptor signaling TGIF1 HEL-S-67p RELA ROCK1 FLNA EP300 ROCK2 SRC CDC42 PAK6 NR0B2 SIN3A GSK3B HDAC1 ARHA PIK3R2 RB1 PIK3R1 NCOR1 FHL2 EFCAB6 RAC1 SUMO1 KAT5 ZMIZ1 HEL32 KDM1A KAT7 NCOA1 ETV5 PIAS2 RHOB TLE5 CREBBP NCOR2 ZNF318 FKBP4 RNF6 STAT3 NR2C2 HEL-S-99n RNF4 PSMC3IP CREB1 BAG1 PATZ1 SMARCE1 UBE2I CCNE1 LIMK2 CARM1 STUB1 RLN1 TGFB1I1 RAN JUN SIRT1 CCND1 MDM2 UBE3A RAD9A PIAS1 FOXO1 RUNX2 SP1 PTEN KAT2B SMIM40 EGFR SMAD4 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260910%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology GRB2 SOS1 TGFB1 SYNE4 ADCY3 SYNE3 ADCY6 SYNE2 SYNE1 ADCY5 HEL-S-15 HEL-S-7a NRAS TMEM43 BANF1 HRAS EMD SUN1 CTGF LEMD3 ADCY8 YY1AP1 LBR ADCY9 PLEC SMAD2 ARHA MAPK1 HEL-S-61 MAPK3 MAP2K1 ADCY1 MAP2K2 WWTR1 SOS2 SMAD4 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5393%HOMO SAPIENS Androgen biosynthesis HSD17B2 CYP3A4 AKR1D1 CYP17A1 CYP3A7 AKR1C1 AKR1C2 AKR1C4 HSD3B2 SRD5A2 HSD17B4 HSD3B1 HSD17B1 HSD17B3 HSD11B1 HSD11B2 POR SULT2A1 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma CS MDH2 NMRK2 SLC19A2 FH NONO GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP4159%HOMO SAPIENS GABA receptor signaling AP2A2 AP2S1 AP2M1 SLC32A1 GABRB3 GABRB2 GABRB1 GPHN GABRE GAD1 GABRQ GAD2 ABAT GABRA2 GABRP GABBR2 GABBR1 GABRA6 GABRA5 GABRA4 GABRA3 SLC6A11 GABRG3 GABRG1 ALDH9A1 AP2A1 SIGNALING LIPIDS%WIKIPATHWAYS_20260910%WP5584%HOMO SAPIENS Signaling lipids EPHX2 PTGES CYP4F2 CYP27A1 ALOX15 CYP7A1 ALOX12 LTC4S GPX4 PTGS2 CYP2C9 PLA2G1B ALOX5 PLA1A CYP2B6 CYP7B1 PRXL2B PLCB1 CYP8B1 COX1 HPGD FADS2 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1A2 MSRB2 MSRB3 CYP1B1 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260910%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CAMK2A GRIN2B CALM1 RELA NFKB1 CAMK2G PBR BCL2 NFKBIA IFNG NOS2 NEFL CYCS GRIN1 TNF CASP9 GUCY1B1 NPPA CNGA1 CNGA3 CNGA4 GUCY1A2 NPPB ACTN2 BAD PDE2A DLG4 IL1B AKAP9 PDE3A CNGB3 CAMK2D CNGB1 CREB1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260910%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC5A1 ALDOB G6PC1 FBP1 HEL-S-49 KHK SORD HEL-S-53e PFKL SLC2A2 GLYCTK IL11 SIGNALING%WIKIPATHWAYS_20260910%WP2332%HOMO SAPIENS IL11 signaling IBSP GRB2 TGFB1 IL6ST ATF1 RELA PTPA IKBKB RPS6KA1 BIRC5 SRC CHUK HRAS BCL2 FES RAF1 IL11 RPS6 PIAS1 IL11RA PIK3R2 RUNX2 PIK3R1 SOCS3 MAPK1 MAPK3 JAK1 MAP2K1 MAP2K2 STAT1 YES1 STAT3 PTPN11 PDPK1 TYK2 ITGA2 BGLAP FYN CREB1 RPS6KB1 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260910%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids CDIPT CHKB PCYT2 CRLS1 PNPLA2 CDS1 DGAT2 PEMT DGAT1 CHPT1 DGKZ PISD AGPAT4 PTDSS2 PLA2G1B PNPLA3 GPAM PTDSS1 GPAT4 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260910%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260910%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCD4 CXCL8 RELA NFKB1 IKBKB PIK3CD CHUK NFKBIA RETN IL12A PLCB3 PLCB4 IL12B PLCB1 PLCB2 AKT3 MAPK14 TNF IKBKG MAPK1 PLCG1 MAPK3 PLCG2 PLCE1 IL6 PLCD3 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2858%HOMO SAPIENS Ectoderm differentiation CDH6 FZD8 FGFR2 BMPR1A GLI3 HDAC10 CTNND2 SNCA ARHGDIG CELSR2 CDH8 PIM1 KRT6A CDON KCNK10 MZF1 ASTN1 LY6E ARX GATA6 STC1 ARHGAP15 ZBTB2 TRPM2 SDCBP PLXNA2 RHPN1 ST8SIA4 HESX1 ZBTB7B GAS2L1 TFAP2A TFAP2C JUP SMURF1 ZBTB16 GREB1 NR2F2 POU2F2 ZFHX4 PAN2 PTPRB PPFIBP2 MAFB MKS1 NUMA1 SCHIP1 LHX1 HMGB2 LDB2 WDR44 SOX2 SIX6 AHI-1 BOC UBTF RAB8B BCAS3 ELOVL4 ELOVL2 TNFRSF11B PAX3 SORCS1 BAZ1A FOXL1 RGMA SERPINB6 CLDN11 TOX3 ARHGAP10 KIFC3 RUTBC3 STX16 RRBP1 DMD TBL1X CLVS1 CAP2 H2BC9 TTC14 MYC TNLG7C C1GALT1 PTPN13 VAX2 RIT1 GLB1 ZNF219 SPRY2 BCOR PDE7A MYORG SOCS2 SHH CTBP1 FOXA2 NF2 ROR2 TCF3 BMP4 FYN TCF7L1 CCL2 OGT NFATC1 NLK FHL2 SKIL NLGN1 TLE5 NR1C2 CTNNA2 PRKAG2 WNT1 SMAD4 FZD5 FZD4 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases MTTP ANXA2 PCSK9 LIPG SCARB1 APOB APOA2 LPL APOE LDLR ABCA1 LIPC APOC2 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260910%WP1403%HOMO SAPIENS AMP activated protein kinase signaling RPS6KB2 PIK3CD HMGCR CPT1C HNF4A MTOR ELAVL1 PIK3R2 PIK3R1 CDKN1A CCNA2 CRTC2 RPTOR RPS6KB1 TSC1 CCNB1 LEP TSC2 CAMKK2 SLC2A4 PLCB1 ADRA1B ACACA CPT1A EIF4EBP1 GYS2 PRKAB2 ADRA1A GYS1 PRKAA2 EEF2K LEPR FASN STRADB PRKAG1 STRADA ADIPOR1 PPARGC1B PRKAG2 ACACB ADIPOR2 PRKAB1 CAMKK1 PRKAG3 CAB39 EEF2 PIK3R3 INS-IGF2 LIPE SLC2A4RG PRKACG INSR PRKAA1 STK11 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260910%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NLRP12 COPS6 ACAP1 AIM2 NLRP10 NAIP RELA IKBKB IL18 CHUK NFKBIA NOD2 DUOX2 CASP5 IKBKG RAC1 CASP9 NDUFA13 NOD1 NLRC4 MEFV NLRP7 NLRP2 NLRP1 IL1B AAMP RIPK2 CARD8 PYCARD CARD9 CASP8 NLRP3 ERBIN CARD6 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260910%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response XBP1 PPP1R15A EDEM1 UBE2E1 ASNS SULT1E1 HEL-S-89n DNAJC3 BCL2L11 NARS1 BBC3 DNAJB11 DNAJB9 HEL-S-125m DDIT3 ERP27 TRIB3 ERN1 ATF3 EIF2A NFE2L2 HEL-S-99n ATF4 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC3 ABCC2 MAPK14 MAPK12 MAPK13 EPHX1 MAPK11 JUN HMOX1 FOS NQO1 GCLC HEL-S-22 NQO2 GCLM SRXN1 ABCC6 KEAP1 NFE2L2 ABCG2 CES1 MAPK8 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260910%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS BCL2L1 TNFRSF1A MAP2K6 GPX1 PPP3CA CASP12 PPP3CC BCL2 SLC1A2 NEFL NEF3 TOMM40 BAX DERL1 NEFH CCS RAB5A MAPK14 HEL-S-2 TNF RAC1 MAP3K5 CASP9 CASP3 MAP2K2 BAD SMIM40 APAF1 HEL-S-44 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL FNTA TGFB1 SPRTN SMAD2 FFAR3 FBN1 INS WRN LMNB2 BANF1 PPARG SMAD4 ICMT LMNA ZMPSTE24 KCNJ6 MUCL3 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260910%WP694%HOMO SAPIENS Arylamine metabolism SULT1A1 CYP1A2 NAT2 UGT1A4 SULT1A2 UGT1A9 RETINOL METABOLISM%WIKIPATHWAYS_20260910%WP5188%HOMO SAPIENS Retinol metabolism RPE65 DHRS4 SDR16C5 ADH1A CYP3A7 RDH12 DHRS9 AWAT2 HEL-S-53e PNPLA4 AOX1 LRAT BCO1 CYP1A1 CYP2A6 CYP2W1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260910%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX5 IRX3 UCP1 ARID5B PRDM16 PPARGC1A TBX1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260910%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R3 PPP2CA HLA-DRB1 CD80 PTPN6 PIK3R2 PIK3R1 PTPN11 PIK3CD CTLA4 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism hCG_1998026 B3GALT2 B3GNT5 B3GALT1 FUT1 FUT3 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260910%WP615%HOMO SAPIENS Senescence and autophagy in cancer TGFB1 RB1CC1 SRC THBS1 VTN INHBA AMBRA1 BRAF CDC25B MTOR IFNB1 IL3 MAP1LC3A GSK3B MAPK14 CEBPB IRF-1 RB1 CDKN1A CDKN1B MAPK1 CCL3 IL6R CDKN2A MAP2K1 ATG14 SPARC IL24 ULK1 BMI1 CXCL14 MLST8 MMP14 ING1 DKFZp686F0183 IL6 MAP1LC3C LAMP2 IRF7 COL10A1 SLC39A2 SLC39A1 IL6ST SLC39A3 SH3GLB1 CXCL8 GABARAPL2 ATG3 GABARAPL1 SERPINB2 MAP2K3 TNLG1B ATG10 JUN ATG12 AKT1S1 DKFZp762B153 SQSTM1 CD44 HRAS IL1A RNASEL BCL2 IFNG GABARAP IGFBP5 RAF1 IFI16 CREG1 UVRAG HMGA1 RSL1D1 ATG16L1 MDM2 IGF1R IGFBP7 CXCL1 COL1A1 INS PLAT PCNA PTEN IGF1 BMP2 IL1B KMT2A SMAD4 COL3A1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260910%WP26%HOMO SAPIENS S1P receptor signal transduction MAPK4 MAPK12 MAPK1 GNAI3 GNAI1 PIK3C2B MAPK3 PLCB3 SPHK2 PLCB1 SPHK1 PLCB2 SMPD2 S1PR1 S1PR3 MAPK7 AKT3 S1PR2 S1PR5 MAPK6 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260910%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation NTRK3 APC NTRK2 ROCK1 SRC CDC42 PAK1 CDC2 RHO WNT3A EPHB2 TRIO AURKB SPRED1 PARD6A GSK3B CFL2 FREP1 CLASP1 MARK1 PRKCA DVL1 LIMK1 TIAM1 TAOK1 CAMK4 MAP1B RAC1 MAPRE1 PHLDB2 F2RL2 PTEN MAPKAPK2 STAT3 NTRK1 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260910%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB3B MTMR2 MFN2 KIF1B EGR2 RABAC1 RAB7A HEL-S-102 LRSAM1 RAB4A RAB4B HSPB8 LITAF RAB11A FIG4 FGD4 NEFL SH3TC2 RAB11B RAB25 SBF2 MPZ PMP22 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260910%WP5145%HOMO SAPIENS COVID 19 structural coverage map AQR NLRP12 IGHMBP2 ISG15 UBC MACROH2A2 PARP14 GDAP2 UBB MACROD1 HEL97 MACROD2 CMTR1 PAIP1 PALS1 MAP3K7IP1 TOMM70 UPF2 NRP1 SLC6A19 ACE2 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260910%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy TCF7L2 TCF7L1 CDH2 ITGA7 ITGA6 CACNA1S ATP2A2 ACTG1 GJA1 SGCD SGCA PS1TP5BP1 SGCB DAG1 SGCG ACTN1 CACNA2D1 CACNA2D3 CACNA2D2 ACTN4 CACNA2D4 CACNB1 CACNB3 SLC8A1 CACNB4 PKP2 DSG2 DSC2 CACNG6 CACNG7 CACNG8 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 JUP DES EMD DMD CTNNA1 CTNNA3 CTNNA2 ITGB1 ITGB4 ITGB3 ITGA2B ITGB8 ITGAV ITGB7 ITGB6 ACTN2 LEF1 CACNA1C ITGA4 CACNA1F LMNA RYR2 ITGA2 ITGA1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CCNE1 HEL-S-67p UBB SLC6A3 PARK2 SNCA TH CYCS HTRA2 DDC MAPK14 MAPK12 MAPK13 MAPK11 UBA7 LRRK2 UBE2L6 UBE2J2 UBE2J1 UBE2L3 CASP9 ATXN2 CASP6 CASP2 GPR37 UBE2G1 CASP3 UBE2G2 SNCAIP PINK1 SEPT5 EPRS1 SYT11 HEL-117 APAF1 CCNE2 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260910%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine DHFR AANAT TH PNMT MAOA ASMT DBH PAH SPR JDP1 PTS MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260910%WP2006%HOMO SAPIENS miR targeted genes in squamous cell ATP2A2 PISD POLD2 SLC38A1 AXL LAMC1 SDCBP TPM1 GAS2L1 UBE2J1 CUL4B CPNE8 VEZT PWP1 PNP DHX57 CIAO2A HOXA7 POGLUT3 GOLGA7 RARS1 ATP6V0E1 TPM3 FNDC3B FNDC3A NCL RAI14 TNFRSF10B SRSF9 POM121 TMED10 CBFB MRPL20 COMMD9 ATP6V1C1 ATP6V1F SLC4A10 TBCA PEDS1-UBE2V1 MOV10 CHMP2A SRPRB ANP32B DKFZp761E1322 RNP24 PICALM ARF4 TRAM1 ADAR MAGT1 MRC2 FGF2 SPTLC1 SH3BGRL3 ANXA2 TMED7 FBXW11 ELOVL5 PRPF40A CTDSP1 CSDE1 PXDN PTMA SEC23A ADIPOR2 MRPS33 AKAP8 DNAJB1 POLR2C PPP1R7 SH3BP4 NF2 PDLIM7 MPZL1 SLC12A2 GALNT7 GALNT1 AP3D1 ARCN1 TMEM59 HES1 SPCS3 E2F3 FMNL2 NEDD4 LAMTOR5 BET1 VCAM1 TGFBR2 THBS1 GFPT1 HEL-S-26 MAP3K8 HSD17B12 P4HA2 YWHAQ HMOX1 SYNE2 TUBA1A TMEM43 HMGA1 RHEB GYS1 SMAD1 RTN4 NRP1 HEL-S-30 AP2A1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260910%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway AGTR1 MAS1 TGFB1 COL1A1 RRAS COL1A2 IL6ST IL11RA NOX4 TGFBR2 ACTA2 HIF1A MAP2K6 JUND MAPK1 TGFBR1 SP1 RAF1 CTGF SMAD4 PTPN11 PDGFD IL11 ACE2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260910%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 GHR USF1 EPHX2 APOA2 LPL PCSK9 APOA4 LDLR LIPC APOB PLTP GPIHBP1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260910%WP4917%HOMO SAPIENS Proximal tubule transport SLC5A1 SLC47A2 ATP6V1A SLC22A6 SLC47A1 ATP6V0E1 SLC1A1 SLC3A1 SLC3A2 ATP1A1 SLC5A2 SLC6A20 SLC4A4 AQP1 CLTRN CA4 ATP6V0A4 ATP6V1E1 ATP6V1C1 ATP6V1D ATP6V1F SLC5A5 SLC22A11 SLC34A3 ABCG2 ATP6V1G1 ATP6V0B SLC6A18 SLC36A2 SLC34A1 ATP1B1 HEL-76 SLC2A2 SLC5A8 SLC16A10 SLC7A9 FXYD2 ATP6V0D2 ABCC2 ATP6V0C SLC22A7 ATP6V1B1 SLC9A3 SLC7A7 ABCB1 SLC6A19 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260910%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies TCF7L2 TCF7L1 TGFB1 CSNK1A1 CEBPA APC CSNK1A1L TNFRSF11B CEBPD PS1TP5BP1 EMD LEMD3 CDK4 MYOD1 PPARG MSTN opn FNTA WNT7B GSK3B SMAD2 CEBPB HDAC1 CTSK HMGA2 MAOA DICER1 RUNX2 RB1 TARBP2 AGO2 CDKN1A NOTCH1 JUNB CREBBP WNT10B AXIN1 BMP2 LEF1 KAT2B ICMT LMNA ZMPSTE24 HES1 HES5 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260910%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GNRH1 IGF1 SST GHRH GH1 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260910%WP1434%HOMO SAPIENS Osteopontin signaling opn MAPK3 MMP9 MAP2K1 ITGAV NFKB1 RELA IKBKB ITGB3 MAPK1 MAP3K14 CHUK MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260910%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms TEAD2 SRC ACTG1 PAK1 PS1TP5BP1 PAK6 PAK4 CTNNA1 MAPK9 ITGB1 ITGB4 MAPK10 ITGB3 ACTA2 YWHAQ YAP1 SGMS1 HEL-S-31 LIMD1 ACTG2 MAP4K3 TEAD3 ITGB8 TEAD4 MAP4K1 MAP4K2 NF2 LATS1 ITGB7 ACTA1 ITGB6 WWTR1 MAPK8 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260910%WP4331%HOMO SAPIENS Neovascularization processes SMAD9 TGFB1 RELA NFKB1 NFKB2 DKFZp781O1323 DLL4 EPHB2 MAPK9 KDR ANGPT1 EPHB4 MMP9 SMAD2 REL HIF1A MAPK1 KIT NOTCH3 NOTCH1 NOTCH4 TGFBR1 MAPK3 FLT4 ACVRL1 RELB CXCR4 SMAD1 CXCL12 KITLG MAPK8 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260910%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRF7 IRAK4 IL10 CXCL8 RELA NFKB1 IKBKB VCAM1 NFKB2 TRAF6 CHUK IL1A NFKBIA TLR8 TLR7 IRAK1 TLR4 MAP3K7IP1 MYD88 MAPK14 TNF IRF-1 REL IKBKG CCL4 CCL3 MAP3K7 RELB ELANE TRAF3 LCN2 MAPK8 IL6 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC2 HDAC3 BTRC PARP14 STAT1 STAT3 RBX1 PARP11 DTX3L SKP1 PURINERGIC SIGNALING%WIKIPATHWAYS_20260910%WP4900%HOMO SAPIENS Purinergic signaling PANX1 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 P2RY2 P2RY1 GNAT1 P2RY13 P2RY10 P2RY11 GNAI3 GNAI1 P2RY14 P2RX7 P2RX6 P2RX5 P2RX4 P2RX3 ADORA2B GNAO1 ADORA2A P2RX2 P2RX1 GNAS LPAR4 GNA11 GNAZ NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway TRADD RIPK1 FADD ISG15 RELA NFKB1 IKBKB TRAF6 TRAF2 CHUK NFKBIA TANK MAPK9 IFNB1 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 OTUD5 MAP3K7 IFNA1 CXCL12 TRAF3 DKFZp686F0183 IRF7 CXCL8 ATG12 MAP3K1 IFNG DDX3Y DDX3X IFIH1 TBK1 CASP10 DHX58 TRIM25 AZI2 IKBKE MITA SIKE1 RNF125 IRF3 IFNE IFNK NLRX1 TNF CYLD MAVS SNW1 PIN1 TBKBP1 NFKBIB IKBKG RIGI MAPK8 CASP8 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260910%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma TEAD2 TSC1 ROCK1 PIK3CD TSC2 PLCB3 PLCB4 PLCB1 PLCB2 AKT3 MTOR TRIO ARHA PIK3R2 PIK3R1 YAP1 PKN3 MAPK1 MOB1A LATS2 PKN2 PKN1 PIK3R3 TEAD3 TEAD4 LATS1 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260910%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL2 TGFB1 GREM1 SMAD2 MAPK14 BMP1 TGFBR2 BMPR1A BMPR2 TGFBR1 LOXL1 LOXL4 SMAD4 MAPK9 MAPK8 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260910%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions APOD KLRG1 GSDMD TGFB1 CD80 PDGFRA IL33 CCL20 IL2RG IL10RB MCAM NFKB1 TGFBR2 TGFBR3 TMEM119 NFKB2 CD68 JAK3 IL2RA IL2RB CDC42 STAT5B CTLA4 PDCD1 NOS2 MYD88 opn STAT4 MMP9 NKX6-1 IL12RB1 SMAD2 MAPK14 FOXP3 PDGFA FOXO3A SOCS3 CSPG4 RAC1 TNFRSF1B TGFBR1 JAK1 STAT1 STAT3 CXCL12 TYK2 NLRP3 IL6 VEGFA IL10RA IL10 IL18 IL2 CD44 IL4 IFNG IL12A TLR4 IGF1R SIRPA AREG HTR7 CNP CXCL1 TNF FOXO1 ITGB3 MBP SOX9 NKX2-2 MOG HEL-S-111 IKZF2 OLIG1 CCR8 OLIG2 CCN3 IGF1 ITGAV CCR6 OSM ROS1 NKX6-2 SSTR2 IL1B FAM20C CD47 EGFR CX3CR1 ITGA2 EBI3 FOXO4 AIF1 CCL1 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260910%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor RHO COL1A1 TGFB1 CTGF MAPK10 ACTA2 STAT3 ENPP2 LPA MAPK9 MAPK8 WNT SIGNALING%WIKIPATHWAYS_20260910%WP428%HOMO SAPIENS Wnt signaling FZD9 CAMK2A FZD8 CAMK2G WNT2B ROCK2 SOX17 CER1 CTNNBIP1 DAAM1 DAAM2 SFRP5 CTBP2 PORCN VANGL1 INVS WNT16 KREMEN1 SENP2 LRP5 PRICKLE2 CXXC4 NKD1 NKD2 WIF1 MAPK9 GPC4 NOTUM CHD8 WNT7B SFRP1 CCND3 CCND2 NFATC2 JUN DKK1 SOST FOSL1 CCND1 MYC FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B DVL1 DVL2 DVL3 CTBP1 RYK ROR1 ROR2 AXIN1 LEF1 MAPK8 TCF7L2 TCF7L1 CSNK1A1 APC FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 GSK3B NFATC1 ARHA NLK RAC1 MAP3K7 DKK2 DKK4 PPP3R1 PPP3R2 hCG_2014051 PPP3CA PPP3CC PLCB3 PLCB4 FZD10 PLCB1 PLCB2 WNT5B PRKCB PRKCA WNT1 NFATC3 WNT4 NFATC4 WNT10B WNT10A FZD2 FZD5 CAMK2D FZD7 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes NR1H3 ELOVL4 CYP7A1 ELOVL2 MVD HMGCR EBP SC5D CYP51A1 DHCR24 LBR SCD CYP46A1 IDI1 MVK IDI2 MSMO1 HSD17B7 ACAT2 TM7SF2 FDFT1 CYP27A1 MYLIP FDPS ELOVL5 HMGCS1 GGPS1 NR1H2 ELOVL3 ACSL3 PLPP6 CH25H ABCG1 ABCA1 FADS2 ACSL1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260910%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA11 NDUFA10 ATP5G1 COXFA4L2 HEL-S-271 ATP6AP2 NDUFC2 NDUFC1 NDUFS8 NDUFS6 NDUFS5 NDUFS4 NDUFS3 ND1 NDUFS1 COXFA4 ND3 ND2 ND5 ND4 ND6 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP6 NDUFB2 ATP5MC2 ATP5MC3 ATP5J NDUFB1 ATP5H HEL-S-123m NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME NDUFA9 DMAC2L NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 GCDH D2HGDH L2HGDH MDH2 ALDH7A1 HEL-S-5 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260910%WP2289%HOMO SAPIENS Drug induction of bile acid pathway ABCC3 SLC51A SLC51B ABCC2 CYP3A4 CYP7A1 NR1i1 SLCO1B1 NR1I3 NR1i2 NR1H4 ABCB11 ABCB1 BAAT SULT2A1 IL5 SIGNALING%WIKIPATHWAYS_20260910%WP127%HOMO SAPIENS IL5 signaling GRB2 SOS1 RPS6KB2 RPS6KA1 JUN STAT5B IL2 RAF1 RPS6 SPRED1 GSK3B SHC1 PIK3R2 PIK3R1 FOXO3A MAPK1 GSK3A IL5RA CSF2RB LYN MAPK3 SYK JAK1 BTK MAP2K1 MAP2K2 STAT1 STAT3 PTPN11 RPS6KB1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260910%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome LMNB2 FNTA CFB CFD RCE1 HEL-S-62p ICMT LMNA GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2276%HOMO SAPIENS Glial cell differentiation CNP GAP43 FREP1 HEL70 MBP ALSTROM SYNDROME%WIKIPATHWAYS_20260910%WP5202%HOMO SAPIENS Alstrom syndrome RFX3 RFX1 TUBG1 TFDP2 RILPL1 MYO5B GPR161 ALMS1 STX5A CEP19 DNM3 ACTN4 VCP IFT81 SMO IFT27 IFT25 RABL2B E2F4 IFT172 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 CEP192 CIMAP3 SNAPIN RFX2 PTCH1 DTNBP1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2406%HOMO SAPIENS Cardiac progenitor differentiation TGFB1 PDGFRA NOG MESP2 MESP1 THY1 TBXT SOX17 MYLK3 DKK1 TBX20 TNNI3 INHBA SCN5A NKX2-5 MEF2C IRX4 IGF2 NRG1 TBX5 ISL1 WNT3A POU5F1 LIN28B LIN28A MYL2 SIRPA ZFP42 KDR MIXL1 NODAL MYH6 GSK3B NCAM1 MAPK14 FGF2 BMP1 INS KIT NOTCH1 FOXA2 SOX1 IGF1 ROR2 GATA4 BMP4 CXCR4 SOX2 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260910%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging SIRT1 PPARG ROS1 NFKB1 FOXO1 HIF1A FOXO3A SIRT3 NAMPT TFAM RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260910%WP2290%HOMO SAPIENS RalA downstream regulated genes RALBP1 HRAS RALA EXOC8 YBX3 RAC3 EXOC2 RAC1 CDC42 NRAS PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260910%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS CDH2 TGFB1 CD80 TLN1 COL4A4 VTN DAG1 LRP5 ACTN4 LRP6 SCARB2 SMARCAL1 PTPRO PAX2 MKI67 CLDN1 YWHAQ CDKN1A CTSL LAMA5 CDKN1B SYNPO NCK1 PLCG1 KIRREL3 TRPC6 KIRREL2 CD2AP INF2 COL4A3 COL4A5 MYH9 IRF6 LMX1B CD151 PARVA NPHS1 MYO1E NPHS2 WT1 FAT1 LAMB2 AGRN CDKN1C LIMS1 CR1 PLAUR DKK1 MME TLR4 HEL113 ITGB1 ITGB4 ITGB3 HEL114 NOTCH1 PCNA WNT1 PLCE1 ITGAV HEL-S-28 FYN MRNA PROCESSING%WIKIPATHWAYS_20260910%WP411%HOMO SAPIENS mRNA processing HNRNPH1 SNRPA1 DNAJC8 SF3B5 SF3B2 RNMT CSTF2T U2AF1 PPM1G PABPN1 POLR2A U2AF2 TRA2B SPOP SNRPB2 SRSF10 SF3A1 SF3A2 HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SMC1A SRPK2 SRSF9 TMED10 NCBP1 NCBP2 PRPF40A METTL3 NONO HNRNPD DICER1 SFPQ HNRNPR SNRPD2 SNRPD1 CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 SNRPN PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA SNRPB DHX8 DDX1 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 FUS CPSF3 CPSF2 WDR57 SFRS3 CLK4 LSM2 CLK2 SRPK1 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 SUPT5H SRP54 YBX1 PTBP1 DHX15 DHX16 RBM5 RBM17 PRMT2 PRMT1 PRPF18 NHP2L1 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism DGAT1 MVD HMGCR EBP SC5D CYP51A1 DHCR24 DHCR7 LBR APOA4 DKFZp434B2017 NPC1L1 SLC27A4 MGAT1 ABCG8 ABCG5 FABP2 SQLE IDI1 MVK MSMO1 HSD17B7 ACAT2 MTTP TM7SF2 FDFT1 FDPS HMGCS1 APOB CD36 LDLR ABCA1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260910%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPIN1 MVD GPAM HMGCR LPL PPARG DKFZp434B2017 SCD SQLE HEL-S-32 IDI1 MTOR MED15 YY1 SREBF2 RBP4 SAR1A INSIG1 RNF139 FDFT1 ACSS1 SEC23B FDPS HMGCS1 SEC31B SEC31A MBTPS1 NR1H2 NFYA AMFR CDK8 SEC24C MBTPS2 CREB1 DBI CYP51A1 SIRT1 FGF21 ACACA PRKAB2 INS PRKAA2 SCARB1 CAMP FASN PRKAG1 PPARGC1B GSK3A PRKAG2 SEC23A PRKAB1 SP1 PRKAG3 ACLY LDLR PRKAA1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260910%WP1584%HOMO SAPIENS Type II diabetes mellitus MAFA IRS1 TNF IKBKB MAPK1 SURF1 PHKA2 INS-IGF2 PRKCZ SOCS4 PIK3R5 PDX1 SLC2A4 INSR MAPK8 SLC2A2 CACNA1A MTOR BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260910%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PCCB BTD PC HLCS ACACA MCCC2 MCCC1 ACACB PCCA ERBB SIGNALING%WIKIPATHWAYS_20260910%WP673%HOMO SAPIENS ErbB signaling CAMK2A RPS6KB2 CBL CRK CAMK2G SHC3 SRC PIK3CD STAT5B PAK1 PAK6 NRG1 PAK4 BRAF MAPK9 AKT3 MTOR GSK3B SHC1 MAPK10 PIK3R2 TGFA PIK3R1 CDKN1A CDKN1B MAPK1 NCK1 BCL2L11 MAPK3 MAP2K4 MAP2K1 NCK2 MAP2K2 NRG2 EREG BAD BTC NRG3 NRG4 HBEGF ERBB3 ERBB4 ABL2 RPS6KB1 GRB2 SOS1 JUN NRAS HRAS RAF1 CCND1 MDM2 EGF MYC ERBB2 AREG PRKCB SHC4 PRKCA SHC2 FOXO1 EIF4EBP1 ARAF PIK3R3 PLCG2 SOS2 CRKL EGFR PDPK1 CAMK2D MAPK8 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members TNKS MAP3K21 MAP3K12 PARP14 MAP2K6 MAP2K3 MAP3K1 MAP3K10 RAF1 MAP3K11 MAP3K8 BRAF MAPK9 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 ARAF MAPK1 MAP3K7 MAP3K5 MAPK3 MAP2K4 MAP2K1 MAP2K2 ATF4 MAPK8 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260910%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY FFAR3 NR1C2 FFAR2 SLC2A4 GCG ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260910%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway SLC7A11 CXCL8 RELA NFKB1 IKBKB TMPRSS2 CCL2 CHUK NQO1 NFKBIA GCLC IL12A GCLM KEAP1 RXRA ACE2 IRF3 TNF IKBKG HMOX1 GUCY1B1 MMP3 GUCY1A2 NFE2L2 IL1B IL6 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260910%WP5124%HOMO SAPIENS Alzheimer 39 s disease FZD9 FZD8 WNT2B PIK3CD WNT16 LRP5 BRAF MAPK9 WNT7B MAPK10 CASP9 CASP3 APAF1 CDK5 CYCS ADAM10 IRS1 INS CHRNA7 APOE INSR NFKB1 LPL APP CALML6 CALML3 CALML4 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 ATG14 DKK2 DKK4 VDAC3 ULK2 ULK1 CSF1 ATF4 PPP3R1 APH1B PPP3R2 NRBF2 XBP1 EIF2AK2 GRIN2B ATG2A NOX4 CALM1 ATG2B RYR3 hCG_2014051 TUBA1C PPP3CA TUBA1B PTGS2 CASP12 TUBA1A PPP3CC NRAS PSENEN HRAS MME TUBB BACE1 PLCB3 ITPR2 PLCB4 TUBB2A PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PSMA8 PSMB6 TUBA3E PSMB2 PSMB3 TUBB4B TUBB4A GRIN1 PSMC6 PSMC4 PSMC1 CDK5R1 HEL-S-276 IRS4 TUBB8 TUBB6 KIF5A TUBB1 MAP3K5 HEL-S-61 CYBB TUBA4A ERN1 ADAM17 PPIF RTN3 PSMD12 PSMD13 PSEN2 GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 HEL-S-162eP NAE1 CACNA1S SHFM1 EIF2S1 RELA TUBA2 IKBKB TUBA8 ATP2A2 ATP2A1 RB1CC1 TRAF2 WIPI1 WIPI2 CHUK SLC25A5 SLC25A6 TUBAL3 HEL-S-91n BECN2 AMBRA1 SNCA NOS2 ADRM1 SLC25A31 SLC25A4 AXIN2 HSD17B10 DKK1 DDIT3 RAF1 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B TNF DVL1 DVL2 DVL3 APC2 AXIN1 IL1B MAPK8 CASP8 FADD CSNK1A1 APC TNFRSF1A CSNK1A1L FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 AKT3 MTOR GSK3B PIK3R2 PIK3R1 MAPK1 MAPK3 MAP2K1 MAP2K2 BAD IL6 IL1A FZD10 WNT5B ARAF PIK3R4 PIK3R3 WNT1 WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260910%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease CEBPA EIF2S1 RELA IKBKB TRAF2 PIK3CD CDC42 MAPK9 BBC3 NDUFA11 NDUFA10 COXFA4L2 CASP3 NDUFC2 NDUFC1 NDUFS8 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 COXFA4 NDUFB9 NDUFA12 NDUFB8 COX6A1 NDUFB7 COX6A2 NDUFB10 NDUFC2-KCTD14 NDUFB6 SDHC NDUFB5 SDHD JUN NDUFB4 SDHA COX6B2 NDUFB2 SDHB COX6B1 DDIT3 COX7A2L NDUFB11 NDUFB1 COX7A2 COX7A1 MAP3K11 COX3 NDUFV3 COX2 NDUFV2 COX7B2 COX7B COX4I2 COX1 COX7C NDUFA9 BAX CYCS MLX COX8A NDUFA7 COX8C NDUFA6 NDUFB3 NDUFA5 COX5A MLXIP NDUFA3 PKLR NDUFA2 ZNF183 UQCRHL IRS1 ITCH NDUFAB1 TNF CYP2E1 INS MLXIPL LEPR NR1H4 ADIPOR1 GSK3A ADIPOR2 NDUFA13 IL1B INSR MAPK8 CASP8 BAK1 TGFB1 TNFRSF1A NFKB1 VCAM1 CCL2 AKT3 NR1C1 GSK3B PIK3R2 PIK3R1 SOCS3 BCL2L11 RAC1 IL6R TNFSF6 ATF4 IL6 XBP1 NR1H3 CXCL8 LEP UQCRB IL1A UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 RXRA CYC1 UQCRC2 PRKAB2 PRKAA2 PRKAG1 MAP3K5 PRKAG2 PRKAB1 PRKAG3 ERN1 PIK3R3 PRKAA1 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260910%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells SOCS1 AKT1S1 STAT5B NRAS HRAS IFNG EPO CDK4 PRL AKT3 IFNGR2 CISH MTOR GH1 PRLR GHR IFNGR1 SOCS2 SOCS3 IL6R CCND3 CCND2 RPTOR STAT1 FOXM1 STAT3 MLST8 EPOR IL6 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260910%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease HTT NTRK2 MAPK1 RPS6KA5 BDNF HRAS MAPK3 RAF1 MAP2K1 CASP3 MAP2K2 EGF EGFR CREB1 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260910%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis TBXA2R GNA13 ARHA ARHGEF1 PTGS1 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260910%WP259%HOMO SAPIENS Nifedipine activity PCNA CYP3A4 MAP2K1 PTK2B MAPK1 BDKRB2 KDR HEL-S-44 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260910%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PDGFRA LYL1 NOP2 BCR GADD45A PIM2 FOXO3A CSF1R CDKN1B KIT GAB2 ABCB1 ABCG2 FLT1 PIM1 SKP2 MYC MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT1A PECR EHHADH ACADVL ACSL3 FACL4 ACSF2 ACADL CPT2 SLC25A20 ACADM ACADS ACSL1 FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260910%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 SEL1L APOA2 LPL APOA4 LDLR APOA5 LMF1 LIPC APOC2 PLTP GPIHBP1 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260910%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism ATG101 SMAD9 TGFB1 RB1CC1 TRAF6 BMPR2 NR1D2 DKFZp781O1323 AMBRA1 WNT16 LRP5 BHLHE41 MTOR VCP IL3 MAP1LC3A CALCA CTSK NFATC1 CRY1 CSF1 ULK1 DKFZp686F0183 IL6 LAMP2 ATG3 TNFRSF11B BMP6 PER1 ATG10 HMGB1 DKK1 ATG12 LEP DKFZp762B153 SQSTM1 SP7 SOST BCL2 ATG16L1 RORB TNFSF11 RUNX2 PRKAA2 NOTCH1 ARHGAP4 FYCO1 PTH IGF1 CTF1 SEMA3A EFNB2 WNT10B BMP4 DRAM2 SMAD1 BMP2 CTHRC1 SMAD4 SEMA4D BMP5 BHLHB2 BMP3 PLEKHM1 TNFRSF11A NPAS2 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260910%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway ACACA HIF1A PDHA1 PRKAG1 ACACB PRKAB1 EGLN1 KEAP1 NFE2L2 PRKAA1 PDHA2 RPS6 SLC11A2 HEL-S-133P VEGFA APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260910%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer BEX3 CUL5 RNF7 IER3 HELLS F2R TRAF1 NFKB1 NET1 BIRC5 CARD14 TNFRSF21 HEL-S-89n THBS1 JUND TNFRSF10B SQSTM1 NQO1 GCLC NRG1 CTNNA1 IL7R HEL-S-7 HEL113 YBX3 HSPD1 HDAC1 TNF PTK2B APP CDKN1A SOCS3 CDKN1B MAPK1 HEL-S-102 PKN1 ERN1 APOE AXIN1 VAV3 RIPK2 ERBB3 RPS6KB1 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260910%WP5546%HOMO SAPIENS 22q11 2 distal CNV AQR SNRPA1 CAMK2A SF3B5 SF3B2 CBL PTPA PARK2 PAK1 SNRPB2 SF3A1 SF3A2 PHF5A UBE2L3 CHEK1 MDM2 UBE3A RPS6 PPIB BCR SOX9 NEDD4 RNF19B HEL-S-89n RPS15 RPS14 VPREB1 RPS17 DNAJB11 RPS16 RPS19 RPS18 CWC22 ROPN1L RPS11 RPS10 RPS13 RPS12 RSPH6A PDIA2 RPS9 RPS7 RPS8 RPS5 DNAJB13 RPSA CRNKL1 PDIA4 RAB36 PPIE DYDC1 SNRNP200 UBA6 CABP1 AK8 CD79B CD79A SDF2L1 CWC15 MAPK1 TDRD3 RPS26 RPS28 RPS29 RSPH14 RPS20 HYOU1 RPS21 RPS24 RPS23 GGTLC2 ZNF280A IQUB HEL-S-107 ARIH1 ELOC HEL-S-99n CCDC116 BUD31 SNRPD2 PLRG1 RPS27A SNRPD1 GNAZ NME5 XBP1 YDJC CANX SNRPD3 RBM22 LRP4 RSPH9 PPM1F RNF113A RPS15A RPS3 RPS2 RILP SNRPG UGGT1 PPIL1 CDC5L SNRPE RSPH3 HEL-S-125m SNRPF IGLL5 XAB2 IGLL1 YPEL1 FAU SNRPB CAMK1 PPIL4 PPIL6 PRPF8 WDR57 SNW1 CAMK4 DNCL1 DHX16 RBX1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260910%WP4400%HOMO SAPIENS FABP4 in ovarian cancer HEL-S-104 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260910%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER1 PTGER3 SRC PTGS2 MAPK1 PIK3CD NRAS HRAS PLA1A MAPK3 PTGER4 BRAF EGFR PTGER2 AKT3 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260910%WP3645%HOMO SAPIENS NAD biosynthetic pathways TNKS SIRT6 SIRT4 SIRT5 SIRT7 TDO2 SIRT2 SIRT3 NMNAT1 NAMPT IDO1 HEL-S-90n SIRT1 PARP4 NADSYN1 PARP2 BST1 TNKS2 NAPRT EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260910%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A IL1B NLRP3 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260910%WP5029%HOMO SAPIENS Amino acid transport defects IEMs CLTRN SLC7A7 SLC1A1 SLC3A1 SLC36A2 SLC3A2 SLC6A20 SLC6A19 SLC7A9 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260910%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HAMP HFE BMP6 ID1 TMPRSS6 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260910%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation FGF19 MAPK3 FGFR4 CYP7A1 LDLR ABCG8 ABCG5 MAPK1 ABCB11 FXR1 SLC10A2 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260910%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CCR2 CTCF SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260910%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP UBC RELA UBB NFKB1 UBE2E1 FOS CDC23 CDC27 ANAPC7 ANAPC5 MAPK7 ANAPC1 ANAPC2 ANAPC10 ANAPC11 CEBPB H2AX CDKN1A CDKN1B MAPK1 CCNA2 MAPK3 CDKN2A FZR1 UBE2C STAT3 RPS27A IL6 CXCL8 RPS6KA2 RPS6KA1 JUN CDKN2D CDKN2B CDKN2C IL1A CDK6 CDK4 CDK2 H2BC9 H2BC21 IGFBP7 H2AC19 H2AB1 UBE2D1 EHMT1 H2AC14 H2BC26 H2BC12L CDC26 HIST1H2AB VENTX H3C8 H2AC6 H2BC17 H2BC12 H2BC13 H4C9 H2AJ H2BC14 HIST1H4L H2BC15 H2BC11 HIST1H2BE ANAPC15 H3C15 C10orf104 H2AZ1 H2AZ2 H2BC8 H3F3B H2BC3 H2BC1 UBE2S H2AC20 ATM SIGNALING%WIKIPATHWAYS_20260910%WP2516%HOMO SAPIENS ATM signaling MDC1 DKFZp781B1423 RIPK1 TP53BP1 CCNE1 CRADD ATF2 CCNB1 GADD45A JUN MRE11A CDC2 RAD50 RAD51 CDK2 MDM2 MAPK9 ATM RAD9A H2AX CDKN1A IKBKG PIDD1 CASP2 CHEK2 TP73 CHEK1 TLK1 NBN SMC1A CREB1 POLYOL PATHWAY%WIKIPATHWAYS_20260910%WP690%HOMO SAPIENS Polyol pathway ALDOB KHK SORD AKR1B1 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN6 PLAG1 DCTN4 PCM1 ACTR1B PLAGL1 KIAA0753 CEP170 BMERB1 GATA3 DISC1 OFD1 RAP1A ABCC1 NDE1 MARF1 DCP1A CEP20 ACTR10 ABCC6 DCP2 PAFAH1B1 RAPGEF4 DCTN1 PLK1 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260910%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism ADH1A DGAT1 HEL-S-53e HEL-S-4 CYP26A1 RXRB RXRG LPL CRABP2 RXRA NPC1L1 RDH8 RETSAT ABCG8 CRABP1 ABCG5 RLBP1 RDH10 DHRS3 CYP26B1 NR1B3 ALDH1A3 RBP7 RBP4 RBP2 RBP1 SULT2B1 RARA RPE65 RARB RDH5 SDR16C5 CYP2E1 RDH12 SCARB1 AWAT2 ALDH1A2 MAPK1 LRAT CD36 BCO1 SULT1A1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260910%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome FMR1 DKFZp781B1423 PCM1 CDC6 PCSK1 NGF RB1 NUP107 NUP188 OXT NPAP1 GABRR3 AHCTF1 GABRR1 HERC2 NUP62 BBS4 CDKN2A NUP214 CCND2 NDC1 GOLGA8S NUP210 NUP133 GOLGA6L2 NIPA1 TACR3 NIPA2 NUP93 SNURF FEZ1 FEZ2 NUP54 NUP98 NUP58 OCA2 NUP205 SLC45A2 SEH1L DLX5 SNRPN ATP10A AAAS NUP160 NHLH2 EIF4E NUP42 NUP85 TPR GHRH NDN NUP88 POM121 MSX1 CDKN2B GHRL RAE1 CDKN2C RANBP2 BDNF NUP155 NUP153 CDK6 HEL-S-71 FSHB TYR KISS1 LHB CDK4 TUBGCP5 TUBGCP6 NUP35 CCND1 MDM2 MKRN3 TUBGCP4 UBE3A CGA GABRB3 GNRH1 POMC RNF8 INS GABRA5 GABRG3 GABRG1 PRKCZ MAGEL2 CYFIP1 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B4GALNT1 A4GALT A3GALT2 GLA B4GALT4 B4GALT5 B3GALT2 B3GNT5 B3GALT1 GBA2 UGT8 UGCG NEU3 NEU4 ST3GAL5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260910%WP4549%HOMO SAPIENS Fragile X syndrome FMR1 PTPN5 CAMK2A EIF4G1 HCN1 SYNGAP1 CLTCL1 AP2S1 ARC SHANK1 SRC HOMER1 AP2M1 DAG1 BRAF ALDH5A1 MTOR MMP9 GAD1 ABAT PPP2R5B SHC1 KCND2 DICER1 TARBP2 AGO2 APP MAPK1 PLCG1 CDKN2A MAP2K1 RPTOR MAP2K2 PTPN11 MLST8 CREB1 RPS6KB1 GRB2 SOS1 GRIN2B TSC1 EIF4E NTRK2 PPP3CA AKT1S1 DKFZp762B153 TSC2 BDNF RAF1 CAMK1 PLCB1 GABRB2 GPHN GRIN1 AGAP2 RHEB CYFIP2 CPT1A PRKCA EIF4A1 SH3GL3 ABCD3 ARAF KCNC1 CAMK4 CLTB MAP1B GRIP1 DEPTOR DLGAP3 SH3GL1 EPHA4 DUSP3 GRIP2 PTEN TTI1 EEF1A1 PRKAR1A ALDH3A2 TBC1D7 PICK1 GRIA2 AKAP5 DLG4 CLTC RAP1GAP CYFIP1 CNR1 CLTA EIF4EBP2 EPS8L1 FYN ARHGAP32 AP2A1 NF1 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation NUDC RELN HEL-S-303 VLDLR PAFAH1B1 NDEL1 DYNC1H1 TUBA1A METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260910%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260910%WP4521%HOMO SAPIENS Glycosylation and related congenital defects MAGT1 DPAGT1 ALG8 DPM2 ALG9 B4GALT1 ALG6 TUSC3 SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 ALG1 ALG11 DPM1 GMPPB DPM3 MGAT2 GCS1 MPDU1 JOUBERT SYNDROME%WIKIPATHWAYS_20260910%WP4656%HOMO SAPIENS Joubert syndrome PCM1 FLNA ZNF423 OFD1 INVS CEP164 CCP110 ARR3 MTOR TCTN3 SUFU TCTN2 TCTN1 BBS9 BBS7 CEP97 BBS5 ARHA CEP290 CC2D2A ARMC9 RPGRIP1L TMEM138 RP2 TMEM216 KAT5 CEP104 ARL3 BBS4 ARL2 ARL13B TMEM67 INPP5E NPHP1 MYO6 PDE6D NPHP3 PDE6A PCNT MKS1 PIBF1 ATF4 BBS2 NEK8 BBS1 PDE6G RAB3IP AHI-1 CPLANE1 TMEM231 TTC8 TMEM17 TMEM237 UNC119 B9D1 CEP41 B9D2 MRE11A RAD50 ATM RHEB SHH DVL1 DVL3 RAB8A CETN2 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260910%WP2328%HOMO SAPIENS Allograft rejection TGFB1 CD80 PDGFRA CD40LG IL2RA CTLA4 IL12B IL22 IL-21 HLA-DMA IL13 AGTR1 HLA-DRB1 FOXP3 LRRK2 CASP9 TNFSF6 ABCB1 IL5 CASP3 STAT1 GDNF CXCL9 CXCL12 VEGFA HLA-DQA2 HLA-DQA1 IL17A IL10 HEL-S-62p CXCL8 CXCL13 C1QC C8A C4A TUBA1B GNLY HLA-DOA IL2 HLA-DOB GABPA IL4 HLA-DPA1 IL1A BHMT2 IFNG HLA-B IL12A HLA-C C1QB HLA-A C1QA CD40 HLA-F HLA-G HLA-E HLA-DQB1 PRF1 CXCR5 HLA-DMB C4B_2 CCL19 HEL113 MICA HLA-DRB5 C6 HARS1 C7 CCL21 C9 CXCL11 CSNK2A2 CD55 HLA-DPB1 TNF PECR PRKCZ IL1B CASP8 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260910%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway MSH2 CRK RELA NFKB1 IKBKB BIRC5 SRC PXN STAT5B CHUK PAK1 NFKBIA NOS2 MAPK9 MMP2 MAPK14 MAPK12 MAPK13 MAPK11 PIK3R1 YAP1 MAPK1 RAC1 NCK1 CASP9 MAPK3 BAD ANGPT4 STAT3 PTPN11 GRB2 SOS1 NRAS HRAS RAD51 BAX MYC ERBB2 ANGPT2 ANGPT1 RS1 ITGB1 GRB14 ANGPTL1 GRB7 FOXO1 EIF4EBP1 TNIP2 TNIP3 IKBKG EGFR MAPK8 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260910%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HGSNAT HPSE2 IDUA HEXA GNS SGSH GALNS HYAL2 HYAL4 HEL-S-111 HPSE GUSB GLB1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260910%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL1A JAK1 HEL-S-10 IL10RA IL10 IL10RB STAT1 STAT3 STAT2 HMOX1 IL6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260910%WP170%HOMO SAPIENS Nuclear receptors NR1C2 NR1H3 NR1i1 RXRB NR1D2 RXRG NR1A2 PPARG RXRA RORC RORA HNF4A PGR NR1C1 NR1B3 NR3A2 RARA RARB NR1I3 NR1H2 NR1i2 THRA NR2F2 NR2E1 ROR1 NR3C1 ESRRA ESRRB NR2F1 NR0B1 NR5A1 NR2C2 NR5A2 NR2F6 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260910%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis MEF2D ZAP70 HDAC1 CALM1 NFATC2 ATP2A1 PPP3CA EP300 PLCG1 PPP3CC HDAC2 ITPRIP CABIN1 CD8B CD8A LCK WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP10 TNK2 BTRC APC TNK1 PLK1 DVL1 AXIN1 DVL2 DVL3 RBX1 SKP1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260910%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CBFB NAE1 UBA3 ELOC RBX1 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260910%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL33 IL17A GFI1 TSLP ATL1-beta TOX IL18 GATA3 IL4 IFNG IL12A IL25 IL12B IL22 RORC RORA GIG8 IL15 IL13 AREG TBX21 IL9 IL7 HNF1A TNF IL23A ZBTB16 IL5 IL1B NFIL3 AHR IL6 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260910%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 MTTP ACSS1 DGAT2 GCKR SEL1L APOA2 LPL APOA4 APOA5 LDLR PDIA2 LMF1 LIPC APOC2 PLTP GCK GPIHBP1 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260910%WP405%HOMO SAPIENS Eukaryotic transcription initiation GTF2B TAF9 POLR2A GTF2E1 GTF2E2 POLR2B POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K TBP GTF2H2C_2 TAF12 TAF13 GTF2F2 POLR3B POLR1A POLR3D POLR3E POLR1D TAF7 GTF2H2 TAF6 POLR3H GTF2H3 TAF5 POLR3K GTF2H4 CDK7 CCNH ERCC2 POLR2C MNAT1 HEL-S-28 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP5414%HOMO SAPIENS IDO metabolic pathway IFNG AADAT TNF GOT2 KMO TDO2 KYNU KYAT3 KYAT1 IDO2 IDO1 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260910%WP691%HOMO SAPIENS Tamoxifen metabolism UGT2B7 CYP1A2 UGT2B15 CYP3A4 CYP2E1 UGT1A8 SULT1E1 UGT1A4 CYP2C9 CYP2C19 SULT1A1 UGT1A10 CYP1A1 CYP2A6 CYP1B1 SULT2A1 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260910%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex ZAP70 CRP NRF HLA-DRB1 CD3G PRG3 CD3E CXCL8 CD2 LBP MMP25 IGLL1 HLA-DRB5 CD8B IL6 CD8A FYN LCK KALLMANN SYNDROME%WIKIPATHWAYS_20260910%WP5074%HOMO SAPIENS Kallmann syndrome PROK2 GRB2 GNRH1 FRS2 ASCL1 TMEM98 PLXND1 SEMA3E FGFR1 ANOS1 MAPK1 OTX2 NEUROG1 OLIG2 LHB SOX10 MAP2K2 PTPN11 MYRF FGF8 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260910%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT1A PECR EHHADH ACADVL ACSL3 SLC22A5 FACL4 ACSF2 HADHB ACADL CPT2 SLC25A20 ACADM ACADS ACSL1 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260910%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts UST CHST3 HS6ST1 HS6ST2 HS6ST3 HS3ST1 HS2ST1 HS3ST2 NDST3 HS3ST3A1 HS3ST3B1 CHST7 CHPF XYLT2 XYLT1 EXTL2 EXTL1 CHSY1 CHST11 CHSY3 CHST12 CSGALNACT1 CHPF2 B3GAT3 CHST13 B3GAT2 CHST14 GLCE B3GAT1 CSGALNACT2 CHST1 B3GALT6 EXT1 EXT2 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260910%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome SIAH1 CDIPT NFKB1 TRAF6 TRAF2 HEL-S-90n UNC13A PPARG PPP2R5D REL MAPK3 HDAC3 SMEK1 DOC2A FAM57B FIMP CCT6B PAGR1 SPN PPP4R1 PPP4R2 MAP2K6 PPP4R4 MAP2K3 HEL-S-69 UNC13B PPP4R3B ASPHD1 TCP1 KCTD13 ZG16 EZR INO80E PPP2R1A HEL-S-87p PAXIP1 KMT2C MVP PARP4 GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT7 BPTF CCT4 IGBP1 MLL2 PRRT2 HEL-S-100n TBX6 C16orf54 CCT6A TAOK2 CCDC6 YPEL3 PCNA PPP2CA PTEN HEL70 NR3C1 CASP8 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260910%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IL1A PRKCZ HEL-S-71 IRAK1 NFKB1 TRAF6 TIFA UBE2V1 AJUBA SQSTM1 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA5 B4GALNT1 ST3GAL1 A3GALT2 ST6GALNAC6 B3GALT1 FUT1 ST8SIA1 SLC33A1 B3GALT4 ST3GAL5 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260910%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 RRAS ARAF MAPK1 NRAS HRAS MAPK3 RAF1 RAB5B RAB5C PDCD6IP RAB27A RRAS2 HGS BRAF RAB5A OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence FADS1 CYP1A2 CYP3A4 EPHX2 PTGES ELOVL2 ALOX15 ELOVL5 CYP2E1 ALOX12 LTC4S PTGS2 PTGS1 CYP2C9 ALOX5 PTGIS HEL-S-22 ALOX15B GPR32 FPR2 HPGD FADS2 GSTM4 CAMKK2 PATHWAY%WIKIPATHWAYS_20260910%WP4874%HOMO SAPIENS CAMKK2 pathway ERMAP GALNT9 MAMDC2 ATP1B2 MID1 ARHGEF7 ERAF STIM1 RELA SPINT1 VCAM1 C1QTNF12 MX2 HMBS ASNS EP300 SFI1 ATP10D TBXT TSPAN33 RHD ENHO PAK1 AQP1 CYB5R3 TSPAN8 SLC25A21 SLC38A5 FIS1 WFS1 TMEM176B KLF1 SELL SLCO3A1 TRPV4 SPIRE1 RHAG KDR IL15 MTOR GCK MAP1LC3A MAPK1 RAC1 DGIC HMOX1 PCK2 MAPK3 S100A8 MAF CRTC2 RPTOR NFE2L2 ULK1 SMC1A CREB1 EPOR RPS6KB1 CCNE1 TSC1 CALM1 NFATC2 DKFZp762B153 SQSTM1 PFKFB2 RAF1 SIRT1 CAMK1 HFE KEAP1 CAMKK2 SLC2A4 CCND1 RPS6 CXCL11 WDR35 TNF ACACA HIF1A CAMK4 FASN ABCA1 FAM20C NLRP1 CHRM3 MS4A3 CCL5 CPOX IFGGE HK2 OASL AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260910%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy HEL-S-78p TGFB1 CACNA1S PLA2G2A STIM1 NFKB1 TGFBR2 ATP2A1 SLC25A5 SGCA FKBP1A NFKBIA CTGF DAG1 NOS2 CACNA2D1 CACNB1 RYR1 MCUB MMP2 SCX TOMM20 SLN opn AGTR1 TRPC3 MMP9 TRPC1 TRDN SMAD2 ORAI1 CACNG1 PRG3 CASQ1 TNNI1 SSPN SNTB1 CASP9 TRPC6 TGFBR1 ELANE IL6 NOX4 IL10 IL1A ITPR2 DMD TNF PRKAA2 CYBB MPO CAPN3 PPIF FGA IL1B SMAD4 CACNA1F PRKAA1 CAMK2D MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260910%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1 GOT2 SLC25A12 SLC25A22 SLC25A13 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260910%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells TNF PRKCA PRKCQ KIR2DL1 PLCG1 RAC1 KIR2DL3 ELF3 LCP2 SYK LAT CSF2 IFNG HLA-C PTPN6 TYROBP NLRP7 NLRP2 VAV1 FYN NEPHROTIC SYNDROME%WIKIPATHWAYS_20260910%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A4 CTLA4 CYP11B2 ALG1 ACTN4 SCARB2 SMARCAL1 ITGB4 PTPRO PAX2 SYNPO TRPC6 CD2AP HEL-S-47e INF2 GPC5 COL4A3 APOL1 COL4A5 YARS MYH9 PLCE1 EMP2 WDR73 LMX1B CD151 COQ6 ARHGAP24 NPHS1 MYO1E COQ2 NPHS2 CUBN WT1 COQ8B LMNA LAMB2 ZMPSTE24 E2F3 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260910%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway GRB2 TNF PRKCA PRKCQ KIR2DL1 PLCG1 RAC1 KIR2DL3 LCP2 SYK HRAS LAT CSF2 IFNG HLA-C PTPN6 TYROBP CD34 VAV1 FYN OVARIAN INFERTILITY%WIKIPATHWAYS_20260910%WP34%HOMO SAPIENS Ovarian infertility FMR1 DAZL FSHR MSH5 DMC1 ZP3 TSC1 INHA ZP2 NR1i1 EGR1 SYNE2 TSC2 RAD51 TBP CDK4 PGR ATM MTOR PRLR NR3A2 CEBPB NCOR1 CDKN1B CCND2 NR5A1 PTGER2 SMPD1 GJA4 LHCGR CREB1 FIGLA WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260910%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates HEL-S-68p FBP1 FOXO1 OTUB2 USP37 PGAM1 SIRT7 HIF1A USP44 OTUD7B U2AF2 USP28 USP19 OTUD6B G6PC1 VHL MYC KDR MTOR HK2 HEL-S-133P VEGFA TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260910%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex EP300 TBP TAF12 POLR1A POLR1D HDAC1 H2AX MAPK3 HDAC2 CREBBP TLK2 UBTF SIRT7 PWWP2B CHD4 CHD3 PWWP2A KAT2A POLR1C RRN3 SRCAP TAF1D TAF1B H2BC9 H2BC21 EP400 MTA2 MBD3 MBD2 GATAD2B GATAD2A CDK2AP1 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H3C8 H2AC6 H2BC17 H2BC12 H2BC13 H4C9 H2AJ H2BC14 HIST1H4L H2BC15 H2BC11 HIST1H2BE H3C15 RBBP4 HAT1 H2AZ1 KAT2B H2AZ2 ASF1A H2BC8 ASF1B H3F3B H2BC3 H2BC1 H2AC20 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260910%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ADH5 CEBPB CBS CYP2E1 HEL-S-53e CREB1 MTR OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP3941%HOMO SAPIENS Oxidative damage response TNK2 C3AR1 TRAF1 CR2 NFKB1 C1QC GADD45A TRAF6 TRAF2 MAP3K1 CDC42 BCL2 C1QB C1QA C1S C5AR1 CYCS C4B_2 BAG4 NFKBIE TNF MAPK13 MAPK10 CDKN1A CDKN1B TNFRSF1B CASP9 PCNA MAP2K4 CASP3 BAD APAF1 TRAF3 CDKN1C BAK1 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling GRB2 SOS1 TLN1 SRC PXN PIK3CD NRAS HRAS RAF1 MAPK9 AKT3 AREG COL1A1 ITGB1 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 MAPK1 MAP2K1 MAP2K2 EGFR MAPK8 ITGA1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260910%WP2596%HOMO SAPIENS Gastric acid production VIP SCT GAST PGA3 PGC PGA5 MUC6 CBLIF CCK HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260910%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex BCL2L1 FLT3 MCL1 GABPB1 EP300 FOXO3A ZFX ETV6 SMARCA4 GABPA BCL2 PTEN CREBBP DNMT3B SMAD4 TERF2 ATM OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260910%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol IL17F CYP3A4 IL17A AKR1D1 EPHX2 CYP7A1 EBP DHCR7 AKR1C4 IL25 CYP46A1 RORC CYP8B1 HSD11B1 HSD11B2 SULT2A1 DBP NR3A2 INSIG1 SULT2B1 CYP27A1 LBP NR1H2 NR1i2 SLC27A5 THEM5 CH25H HSD3B7 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 BAAT ACOT13 CYP7B1 AMACR GPR183 IL17D ACOT6 IL17C SLC27A2 IL17B ACOT4 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260910%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle MSTN IFRD1 CYR61 DUSP14 NR4A3 ANKRD1 EIF4EBP1 EIF4E IL18 JUND IL1R1 IL1A IFNG ATF3 HBEGF MYOG HEL-S-52 ADAM10 VEGFA GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260910%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR ENO1 HEL-S-68p ALDOB FBP1 HEL-S-162eP HEL-S-165mP HEL-S-49 KHK AQP9 GPD2 PNPLA2 AGXT GPD1 PGAM1 MGLL G6PC1 AQP7 LIPE PCK1 HEL-S-87p PC PFKL GLYCTK MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260910%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 CEBPB ELOVL5 TGFBR2 CAP1 PHC2 IGF2R SRSF9 TMED10 TMEM43 SRSF10 LPL CYP1B1 PICALM NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260910%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium NTRK3 IL17A VLDLR NDEL1 NTRK2 ID1 RET MRE11A RTN4R LRP8 DISC1 DAB1 GHRL NUMB BDNF NEUROG3 MEF2C FAIM NRG1 CDK5 NEUROD1 PAFAH1B1 MYC GIG8 NGFR GSK3B ASCL1 CDK5R1 MAP2 NGF PLXND1 APP MAP1B NOTCH1 KDM1A RELN TCF4 TCF3 STAT3 CXCL12 PSEN1 AGRN HES1 RTN4 ERBB4 SOX2 NTRK1 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma TCF7L2 FZD9 TCF7L1 CSNK1A1 FZD8 APC CSNK1A1L WNT2B SOX17 CER1 CTNNBIP1 SFRP5 CTBP2 SOX7 PORCN WNT16 FZD1 KREMEN1 SENP2 FZD3 LRP5 WNT3A CXXC4 WNT7A NKD1 NKD2 WNT3 WIF1 LRP6 NOTUM CHD8 ELAVL1 WNT7B GSK3B SFRP1 NLK CCND3 MTDH CCND2 DKK2 EZH2 DKK4 hCG_2014051 JUN KLF4 DKK1 SOST FOSL1 FZD10 CCND1 MYC FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 WNT5B CSNK2B DVL1 DVL2 DVL3 CTBP1 RYK ROR1 WNT1 ROR2 WNT4 AXIN1 WNT10B LEF1 WNT10A FZD2 FZD5 FZD7 SPINA BIFIDA%WIKIPATHWAYS_20260910%WP5150%HOMO SAPIENS Spina bifida MTHFD1 DNMT3B AHCYL2 SHMT1 MTRR MAT1A MTR UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260910%WP4925%HOMO SAPIENS Unfolded protein response XBP1 EIF2S1 PPP1R15A PMAIP1 MBTPS1 HEL-S-89n TNFRSF10B BCL2L11 BBC3 DDIT3 MBTPS2 BCL2 ERN1 CASP2 RTCB TXNIP NFE2L2 IL1B ATF4 MONOAMINE GPCRS%WIKIPATHWAYS_20260910%WP58%HOMO SAPIENS Monoamine GPCRs DRD1 DRD2 DRD3 DRD4 ADRB3 HTR1E HTR1F HTR1D HTR1A HTR1B CHRM4 CHRM5 ADRB1 ADRA1D ADRA1B HTR4 HRH1 HTR6 HRH2 DRD5 ADRA2C HTR7 HTR5A ADRA2B ADRA2A ADRA1A ADRB2 HTR2B HTR2A CHRM3 CHRM1 CHRM2 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260910%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis HTRA2 DIABLO FADD CASP9 AIFM1 CASP6 BCL2 TNFSF6 CASP3 PRF1 BAX APAF1 CYCS CASP8 BAK1 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260910%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation ATG101 WDR45B TNF GABARAPL2 PTK2B RB1 GABARAPL1 RB1CC1 TRAF2 MAP3K5 GABARAP ATG16L1 ULK1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260910%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens IRS1 GDF15 HSPD1 MARS1 TSC1 OMA1 FOXO1 PHB2 SESN2 LONP2 TSC2 SLC7A7 EIF2A LONP1 MYC CLPP ATF4 MTOR GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260910%WP455%HOMO SAPIENS GPCRs class A rhodopsin like BDKRB2 RHO GPR37 GPER FFAR2 C3AR1 HRH3 ADORA2A GPR75 GPR32 CHRM3 MAS1 HTR1E HTR1F HTR1D HTR1A HTR1B KPG_011 CCR3 CCR2 FPR2 LTB4R CMKLR1 PTGER4 MC4R CXCR4 PTGER2 LHCGR FSHR P2RY6 P2RY4 PTGER1 P2RY2 PTGER3 P2RY1 ADRB3 P2RY13 P2RY10 P2RY11 P2RY14 ADORA2B KPG_010 LPAR4 CCR8 CCR6 GPR83 SSTR2 CX3CR1 CHRM2 F2R CHRM4 CHRM5 ADRB1 ADRA1D HTR4 HRH1 HTR6 HRH2 DRD5 ADRA2C HTR5A ADRA2B ADRA2A NPFFR2 OXTR RRH GRPR GPR174 GPR173 EDNRA EDNRB GPR171 CMKLR2 GPR37L1 FPRL2 TRHR ADRB2 FPR1 OR1I1 IL8RB MC2R GALR3 GALR2 NPBWR1 GALR1 NPBWR2 OR6B1 NTSR1 CCR10 NTSR2 CCR1 GPR17 XCR1 OR2J3 OR2J2 OR2J1 NMBR MC1R RGL4 OR6A2 OR7C2 OR7C1 GPR18 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR OPN1LW NPY2R CCR7 ADRA1B FFAR1 CCR5 CCR4 GPR39 OR5F1 HTR7 GPR34 AVPR1B GPR31 AVPR1A OR5V1 OPN1MW CCKBR OR3A3 BDKRB1 OR3A2 OR3A1 ADRA1A OPRD1 OR10H1 OR10H3 GPR45 OR10H2 GPR42 CXCR1 CXCR3 MTNR1A OR2AG1 CHML MTNR1B GPR52 GPR50 GPR4 GPR3 GPR6 MC5R F2RL1 F2RL3 OR1C1 CNR1 GPR68 GPR65 GPR63 CCRL2 GHSR OR2D2 NPY1R OR2T1 OR1A2 DRD1 GPR161 OR1A1 DRD2 OR2C1 DRD3 SUCNR1 DRD4 OR5I1 C5AR2 GPR87 OPN4 GPR85 MCHR1 OPN3 OR2S2 HCAR3 OR1Q1 HCAR1 OR2B6 OR2B3 OR2B2 NMUR2 NMUR1 OR2A4 OR7A10 OR14J1 MLNR OR1G1 PRLHR OR8D2 OR7A17 NPY5R OR1F1 AGTR1 OR2H2 AGTR2 OR2H1 AVPR2 FFAR3 OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 MC3R OR10A4 OR10A5 OR1E2 OR1E1 NPY4R CNR2 OR8B8 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OR2F1 OPN1SW ACKR4 HTR2B ACKR3 HTR2A ACKR2 OR11A1 PTGFR CHRM1 PTGDR2 TBXA2R PTGDR HCRTR2 PTGIR HCRTR1 NPFFR1 CXCR5 OPRK1 F2RL2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260910%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation NOG RUNX2 BMPR1A SMAD1 BMP2 SMAD4 BMPR2 TOB2 TOB1 SMURF1 SMAD6 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260910%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death MAP1LC3A SH3GLB1 TSC1 ATG3 INS ATG10 ATG12 TSC2 BCL2 AMBRA1 UVRAG ATG14 CHAF1A ATG16L1 ULK2 ULK1 INSR ATG9B VMP1 DKFZp686F0183 PURINE METABOLISM%WIKIPATHWAYS_20260910%WP4792%HOMO SAPIENS Purine metabolism PNP AMPD1 ADSL APRT XDH IMPDH1 HEL-S-70p ADSS ADA DGUOK GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260910%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GCLC GGCT HEL-S-64p OPLAH NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260910%WP5399%HOMO SAPIENS NPHP1 deletion syndrome MAPK3 FLNB INVS NPHP1 PTK2B FLNA RPGRIP1L MAPK1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL17F CXCL1 IL12RB1 IL17A CCL20 IL17RC TNF CXCL8 IL23A HLA-C CCR6 IL12B IL22 IL23R STAT3 IL1B TYK2 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer TGFB1 CD80 VTCN1 IL10 VSIR ICOS NR1i1 TIGIT CCL17 B2M CD40LG TNFRSF4 HAVCR2 ENTPD1 CTLA4 CCL22 TNLG5A IL4 PDCD1 TNFRSF9 PDCD1LG2 FAP CD226 HLA-A CD40 PDGFD PDGFC IL13 VEGFC LGALS9 ARG1 PDGFA SHH NT5E IDO1 TNLG2B TNFSF6 VEGFB VEGFD CXCR4 CXCL12 IL6 VEGFA RETT SYNDROME%WIKIPATHWAYS_20260910%WP4312%HOMO SAPIENS Rett syndrome ACTL6B SCN8A GRIN2B SYNGAP1 CRK SYNE2 CHD4 XAB2 MEF2C GNAO1 KDM5B TRRAP TBL1X FOXG1 GPS2 RHOBTB2 TAF1B CECR2 BRAF HIVEP2 SCN1A SRRM3 EIF2B2 CDKL5 KCNJ10 SMARCA1 TBL1XR1 IMPDH2 HAP1 HTT SCN2A HDAC1 GABBR2 SHANK3 GABRA3 NCOR1 HDAC5 HDAC8 SMARCA4 TCF4 NCOR2 STXBP1 SMC1A EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260910%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis ERI1 XPO5 DICER1 DGCR8 AGO2 DROSHA INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260910%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling TCF7L2 TCF7L1 CSNK1A1 CEBPA APC CSNK1A1L CEBPD EMD CDK6 PPARG SLC2A4 CCND1 opn FNTA GSK3B CEBPB HMGA2 DICER1 RUNX2 TARBP2 AGO2 TOR1AIP1 WNT10B AXIN1 LEF1 ICMT LMNA ZMPSTE24 HES1 HES5 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260910%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GRIN2B SYNGAP1 TSC1 NTRK2 ARC PIK3CD HOMER1 NRAS TSC2 HRAS BDNF UBE3A AKT3 MTOR GRIN1 GSK3B RHEB SHANK3 EIF4EBP1 PIK3R2 PRKAB2 PRKAA2 PIK3R1 CAMK4 MAPK1 GRIN3B PRKAG1 GRIN3A PRKAG2 PRKAB1 PRKAG3 MAPK3 PIK3R3 PTEN RPTOR CACNA1C DLG4 PRKAA1 RPS6KB1 NF1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260910%WP4823%HOMO SAPIENS Genes controlling nephrogenesis FGFR2 RET GLI3 SIX1 TCF21 KDR FGF8 EMX2 FOXD1 ITGB1 SHH PAX2 NOTCH2 NCK1 ROBO2 CD36 HOXD11 HOXA11 SLIT2 CD2AP ETV4 EYA1 WNT4 NCK2 LMX1B GDNF CXCR4 MAFB NPHS1 CXCL12 NPHS2 WT1 LAMB2 LHX1 FOXC2 HEL-S-28 FOXC1 VEGFA TCF2 IL7 SIGNALING%WIKIPATHWAYS_20260910%WP205%HOMO SAPIENS IL7 signaling IL7 GSK3B IL2RG PIK3R2 PTK2B PIK3R1 MAPK1 JAK3 STAT5B MAPK3 JAK1 MAP2K1 MAP2K2 STAT1 BAD STAT3 IL7R FYN MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260910%WP3298%HOMO SAPIENS Melatonin metabolism and effects CAMK2A AANAT CYP1A2 ACHE CALM1 NFKB1 PER2 hCG_2014051 PER1 PER3 TRAF6 SIRT1 CYP1A1 IRAK1 ADRB1 EDN1 CYP1B1 GSK3B FOXO1 PRKCA MAOA MAP2 ASMT CRY2 CSNK1D CYP2C19 CRY1 MTNR1A SULT1A1 ECE1 MTNR1B APOE MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260910%WP4316%HOMO SAPIENS miRNA degrading enzymes PNPT1 EXOSC4 XRN1 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260910%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation VGLL4 CDH6 CDH19 CDH2 ITGA7 CDH24 PDGFRA ITGA6 PPP1R14A FGFR4 CDH16 FGFR3 FGFR2 FGFR1 CSF1R PAK1 PAK6 CTGF PAK4 CDH8 LIN28B KDR CUL4A KIT YAP1 TEAD3 TEAD4 LATS1 FLT1 WWTR1 FOXM1 NTRK1 TEAD2 NTRK2 NRAS CD44 HRAS PLCB4 EPHA2 CCND1 CTNNA1 IGF1R MYC PPP1CC NGFR HEL-S-80p ITGB1 ITGAM ITGB4 ITGB3 ITGA2B FLT3 ITGAE AJUBA LATS2 FLT4 ITGAX ITGB8 PRKAR1B PRKAR1A NF2 PRKACG ITGAV CDH9 ITGB7 AMOT ITGB6 DCAF1 CDH4 ITGA4 CDH10 EGFR CDH11 ITGA2 RBX1 CDH12 INSR ITGA1 CDH15 DDB1 CDH17 CDH18 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260910%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation MEF2D CUL5 RNF7 ITK DGKA CD3D RELA NFKB1 IKBKB TMEM222 GRAP2 ARIH2 SOCS1 UBASH3A TRAF6 DGKZ RASA2 CARD11 BCL10 CHUK RPRD1B SH2D1A ARHH NFKBIA FIBP CD5 AGO1 PTPN6 MAP3K8 MAP3K14 CD3G CD3E REL PIK3R2 PIK3R1 CDKN1B PLCG1 LCP2 LAT MAP4K1 VAV1 GRB2 SH2B3 NDUFB10 TNFAIP3 ZAP70 GNA13 PRKCQ IKBKG PDPK1 CD8A LCK RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260910%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260910%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRF7 TICAM1 IRAK4 RELA NFKB1 IKBKB NFKB2 TRAF6 CHUK TLR8 TICAM2 TLR7 IRAK1 TIRAP TLR4 TLR1 TLR3 TLR9 TBK1 MYD88 IKBKE IRF3 REL TLR5 IKBKG MAPK1 RELB TRAF3 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260910%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G7 PLA2G5 SLCO2A1 PLA2G6 PLA2G10 CDKN1A PTGS2 PLA2G1B ALOX5 HRAS PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLA2G4C PLA2G3 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260910%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CAMK2A ANKRD1 RAF1 ADRB1 MDM2 TRIM63 FHL1 TTN CSRP3 ANKRD2 PRKCA HEL-S-101 ANKRD23 C22orf13 NBR1 FHL2 MAPK1 TCAP MYPN TRIM55 NUP62 GUCY1B1 MAP2K1 PRKAR1A PRKACG ADRB2 MAP2K2 HUNGER AND SATIETY%WIKIPATHWAYS_20260910%WP5445%HOMO SAPIENS Hunger and satiety POMC PYY MC4R NPY LEP GCG AgRP GHRL ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260910%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma ADCY3 ADCY6 ADCY5 MYL4 MYL1 MYL3 PLCB3 PRKAR1B ADCY8 PLCB4 PRKAR1A NR3C1 ADCY9 ADCY1 ADRB2 GNAS PLCB1 PLCB2 MYL2 CREB1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260910%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260910%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways CEPT1 CHKB PCYT2 CTH HEL-S-64p AHCYL2 GPX2 GPX1 SHMT1 PEMT HEL-S-61p CHPT1 GPX4 AMT GPX3 TYMS HEL-75 DHFR GCLC MTHFD1L MTHFD1 GCLM MTHFD2 CHDH DNMT3B GAD1 GAD2 PSAT1 PHGDH PSPH AHCYL1 SLC25A48 DNMT3L PCYT1B GPX7 BAAT MTHFD2L pcap CHKA AGXT2 HEL-S-182mP CDO1 HEL-S-75p BHMT2 BCAT1 BCAT2 ALDH7A1 MTR GPX6 HEL-S-51e CBS MAT1A HEL-S-44 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260910%WP2005%HOMO SAPIENS miR targeted genes in muscle cell TXN2 GJA1 C1QBP SRSF10 TDG GPAM POLD2 USP1 AXL CACNA2D1 MAPK7 DSG2 MAPK14 MAPK12 POLE4 RB1 NFIA MCL1 CDKN1A CDKN1B UBE2J1 LMNB2 CUL4B EZH2 TMEM41B BACH1 CPNE8 CHORDC1 ERBB3 VEZT RAVER2 PWP1 SEC62 VPS39 CDK5RAP3 CIAO2A MBNL1 CARHSP1 WDR82 POGLUT3 FAR1 SLC7A11 TMEM87A RARS1 ATP6V0E1 HACD3 GRPEL2 TPM3 FNDC3B SNX6 FNDC3A RAB27B NCEH1 NCL SFXN1 RAI14 TNFRSF10B GFM1 SRSF9 ASH2L PTPRF TMED10 COIL CBFB MRPL20 POLA2 SERP1 COMMD9 TMED3 CDK6 ATP6V1C1 GNPNAT1 CTSC MRPS24 SLC4A10 TMT1A CCNG1 TBCA AP3B1 MOV10 SLC7A6 CDCP1 CHMP2A VSNL1 SRPRB ANP32B FRG1 SSNA1 DKFZp761E1322 RNP24 AMIGO2 FSTL1 PICALM ARF4 NAPG TRAM1 PGRMC1 SHOC2 ADAR MAGT1 CA12 PPIB MRC2 SPRYD4 IRS1 SPTLC1 TTC9C SH3BGRL3 ARHG GNA13 TMED7 WDR11 TPPP3 SNX15 LAMTOR3 CSDE1 TUSC2 PXDN LTN1 MTRR PTMA ARID4B HEL-S-273 SEC23A ABHD10 KPNA3 ATG9A DNAJB1 STX7 POLR2C PPP1R7 UBE4A RAB30 SH3BP4 GEMIN7 NF2 PDLIM7 MPZL1 ERG SLC1A4 SLC12A2 CORO1C GALNT7 CAMTA1 GALNT1 AP3D1 CD164 ARCN1 BRPF3 GNL3L SPCS3 CPOX SLC25A1 STRN DOCK5 FMNL2 NEDD4 FADS2 CALCOCO2 LAMTOR5 SNAP23 DOCK7 BET1 TNFAIP2 CDIPT TMEM109 ACP2 HEL-S-108 SNAP29 SCYL1 HSDL1 TGFBR2 ARID1A RCN2 RFT1 RBMS1 THBS1 LUZP1 NUFIP2 NXN UHRF1 ACVR1B CAND1 SLC38A5 TP53INP1 IGF2BP1 ZNF622 LPL SLC25A24 NHERF2 SLC4A7 RQCD1 HSD17B12 SLC25A32 ELMOD2 CEBPB P4HA2 PSAT1 SLC25A13 HMOX1 HEL-S-47e CXCL12 CSF1 PANX1 PPP3CA SYNE2 SYNE1 TMEM43 BACE1 COL1A1 COL1A2 EHMT1 RHEB PKN2 PPIF COL3A1 PDE3A RTN4 HEL-S-30 IFRD1 CYR61 PTPA GPD2 ATP2A2 IGF2R PISD SLC38A1 RDH10 LAMC2 LAMC1 SDCBP MYLIP TPM1 CDKAL1 KIT HEL-S-66 NT5E EIF4E BCL2 CCND1 ERBB2 CYP1B1 FGF2 CSNK1D ADIPOR2 GRIA2 EGFR HES1 E2F3 GSTM4 HEL-S-303 TYMS GFPT1 MTHFD2 ABCG2 ANAPC1 HYAL3 PLK1 CLDN1 YWHAQ SPARC MYO1E CYP51A1 HMGA1 PRKCI SYPL1 ITGB4 NOTCH2 PHLDB2 NOTCH1 NELFCD DHX15 ITGA2 NRP1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260910%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A IL10RB CAMK2G SLC17A6 ARC SLC17A7 DISC1 FOS SLC38A1 NGF IL13RA1 TNFRSF1B TGFBR1 CREB1 IL10RA IL1R1 BCL2 DLD PPP1CC CNTF HEL-S-80p IRS1 FGF2 TNF CAMKK1 LIF HEL-S-51e IGF1 SLC1A4 GRIA2 IL1B INSR TGFB1 TNFRSF1A NFKB1 TGFBR2 TGFBR3 SLC1A1 NFKB2 SHMT1 IL1R2 SLC38A5 IL12B PIG59 NELF SLC38A3 GRIA3 GRIA4 IL13 DAO GLS2 GLS SLC6A9 GRIK5 GRIK3 SMAD2 GRIK1 GRIK2 IFNGR1 SLC7A10 GRM2 GRM8 DLAT TRAF5 PSAT1 SOCS3 LTA SLC2A3 PHGDH LRRC8C MAPK1 LRRC8D LRRC8E IL6R PSPH MAPK3 JAK1 ADCY1 STAT1 STAT3 IL6 GRIN2B IL6ST CALM1 IL10 ADCY3 HEL-S-15 GFAP IL4 BDNF IL1A IFNG IL12A PLCB3 PLCB4 ADCY8 SLC1A2 CAMKK2 PLCB1 PLCB2 IFNGR2 GRIN1 PRKCB PRKCA PDHA1 CAMK4 GRIN3B GRIN3A SMAD4 SLC1A3 CAMK2D ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260910%WP4298%HOMO SAPIENS Acute viral myocarditis EIF4G1 TGFB1 CD80 TICAM1 NFKB2 SOCS1 CD40LG SRC SGCD SGCA PS1TP5BP1 SGCB DAG1 SGCG IL12B CCR3 EDN1 NOD2 HLA-DMA MYH6 MMP9 GSK3B TLR5 PIK3R1 MAPK1 CAAP1 CASP9 DFFB CASP6 DFFA MAPK3 CASP2 JAK1 CXADR PABPC1 CHRAC1 CASP3 BNIP2 AAG1 STAT1 CXCR4 STAT3 PYCARD CREB1 IL6 ABL2 SOS1 BCL2L1 IL10 IL2 BCL2 IFNG IL12A DMD TLR4 TLR3 CCND1 BAX CYCS CCR5 MICA CD55 TNF RAC3 CASP8 HEL-S-28 AIF1 FYN LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260910%WP3601%HOMO SAPIENS Lipid particles composition APOA2 APOC3 LPL APOE LDLR APOC2 APOB ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260910%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260910%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP3A4 CYP2C9 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260910%WP2857%HOMO SAPIENS Mesodermal commitment pathway FZD8 SNAI1 BMPR1A TOX FGFR1 SOX17 BMPR2 C1QBP CTBP2 HNF4A NR1B3 GATA6 AXIN2 RARB ZFHX4 PBX1 CUL4B SESN1 SCHIP1 AMH EXT1 FOXC2 SOX2 EXT2 FOXC1 PITX2 TEAD2 KLF4 DKK1 TOX3 CRTC1 CCND1 FOXA1 HTT TBX6 ACACA CCDC6 FOXA2 TCF4 BMP4 AXIN1 LEF1 BHLHB2 TCF7L1 LEFTY1 NOG FOXH1 KLF5 GATA3 LEFTY2 INHBA SMAD6 DNMT3B WNT3A POU5F1 WNT3 MIXL1 NODAL SMAD2 ACVR2A HMGA2 NLK YAP1 TBX1 ARID5B BMP7 LATS1 SOX21 NFE2L2 TRIM28 CEP250 RPL38 HES7 ACVR1 WDHD1 EMSY ADAM19 TWSG1 WDFY2 BCORL1 MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 GDF3 NABP2 TRIM71 BCAR2 SETD2 PHF6 CSRP2 ZIC2 ZIC3 TRIM5 JARID2 SLC2A12 MSGN1 TET1 PARP8 ARL4A AEBP2 HAND1 AHDC1 C9orf72 WDCP ZNF462 ELP4 FGF8 ZIC5 ACVR2B TBX3 MEIS1 RGS10 PIAS1 PPP2CA PRKAR1A SMAD1 VAV3 SMAD4 FZD5 FZD4 PLCH1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP304%HOMO SAPIENS Kit receptor signaling GRB2 SOS1 CBL CRK RPS6KA1 INPP5D SOCS1 EP300 SRC STAT5B GAB2 HRAS RAF1 PTPN6 RPS6 GRB10 MAPK14 SHC1 SOCS6 PRKCB GRB7 SH2B2 MATK PRKCA PIK3R2 DOK1 PIK3R1 TEC FOXO3A MAPK1 KIT PLCG1 LYN MAPK3 BTK MAP2K1 MAP2K2 STAT1 BAD CRKL STAT3 PTPN11 KITLG VAV1 MAPK8 FYN RPS6KB1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260910%WP5601%HOMO SAPIENS Caffeine in blood vessels HEL-S-80p CALM1 RYR3 PDE4D ADCY3 ADRA1A PDE3B ADCY6 MYLK PDE4B ADCY5 PDE4A PPP1R12C ADORA2B ADORA2A ADCY8 ADCY9 GUCY1A2 ADCY1 ADRA1D ADRA1B PDE3A RYR2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260910%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction RIPK1 EIF2AK2 TICAM1 NFKB1 IKBKB TRAF6 JUN CHUK FOS NFKBIA TLR7 IFIH1 TBK1 IFNAR2 STAT2 MYD88 IKBKE IRF3 MAPK14 IRF9 IFNAR1 MAVS IKBKG RIGI MAP3K7 OAS2 OAS3 JAK1 STAT1 TYK2 TRAF3 MAPK8 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260910%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260910%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation SIX4 PTBP1 CTDSP1 STRADB PRKAA1 STK11 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260910%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFAF1 TIMMDC1 NDUFA10 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 ND1 NDUFS1 ND2 ND5 ND4 ND6 NDUFB9 NDUFA12 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB11 NDUFB1 NDUFV3 ECSIT NDUFV2 NDUFA7 NDUFA6 NDUFB3 NDUFA5 NDUFA3 NDUFA2 ZNF183 ND4L NDUFAB1 NDUFA13 TMEM186 C3orf60 ACAD9 TMEM126B DMAC1 DMAC2 TMEM70 COA1 NUBPL NDUFAF6 NDUFAF4 NDUFAF2 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260910%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CSN3 CDH2 CHL1 GRIN2B NCDN KCNQ2 MAP4 NTNG1 CADM3 CAMK2G CASK TERF2IP STX2 ATP2B1 DAB1 PLCB4 CAV2 MAPK9 KCNJ6 GPHN MAPK4 GRIN1 GRIK2 CLASP1 GABBR2 SNW1 KCNMA1 PRKCZ CADM1 EFNA5 RAP1GAP AGRN GPCRS OTHER%WIKIPATHWAYS_20260910%WP117%HOMO SAPIENS GPCRs other F2R DRD3 DRD4 OR2M4 C5AR2 GPR61 GPR62 ALG6 CELSR1 CELSR3 RXFP3 GPR176 HTR1F GPR132 GNRHR OR2B6 GPR135 ADGRV1 TAAR5 OR1J2 CELSR2 TAAR2 OR2A4 OR1N1 ADRA1D CCR2 GPR162 OR1R1 OR1G1 OR5AC2 ADGRF5 VN1R1 OR10A2 OR6C3 OR1F1 OR6C2 OR8G1 OR2H1 GPR88 GPR84 MCHR2 GHRHR OR5D3 GPR55 EMR3 ADGRD1 OR10A5 GPR143 OR2A5 OR1E1 LGR6 ADGRL2 GRPR ADGRL3 OR7E24 EDNRA OR2F1 ADRB2 HTR2A IL8RB PTGFR FSHR NTSR1 GPR17 P2RY13 P2RY11 GPR18 ADORA2A CCR5 S1PR1 HTR7 UTS2R CCKBR OR3A3 SMO OR3A1 CXCR1 CXCR3 GPR183 SSTR2 GPR83 CHRM3 CNR1 CHRM2 FOXP3 IN COVID 19%WIKIPATHWAYS_20260910%WP5063%HOMO SAPIENS FOXP3 in COVID 19 CD80 IL6ST IL2RG FOXP3 STAT3 IL7R IL2RA IL2RB STAT5B IL2 IL6 IL6R SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260910%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260910%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart MAPK14 IL6ST PRKCB PRKCE CALM1 ARHA MAPK11 MAP2K3 PPP3CA JUN MAPK1 RAC1 MYEF2 FOS CTF1 NFATC4 GATA4 EDN1 STAT3 CAMK2D MAPK8 NRF2 PATHWAY%WIKIPATHWAYS_20260910%WP2884%HOMO SAPIENS NRF2 pathway SLC5A1 FGF13 HSP90AB1 SLC2A2 SLC39A9 FTH1 SLC39A6 SLC39A5 SLC39A8 SLC6A17 SLC6A16 SLC6A13 HEL126 ALDH3A1 SLC5A9 CES8 CES3 HBEGF CES2 EPHA3 SLC5A3 SLC5A4 SLC2A9 HEL-S-128m SLC6A5 SLC6A7 SLC6A8 SLC7A11 MAFF SLC2A6 SLC2A7 SLC6A2 SLC2A8 SLC6A3 SLC2A14 SLC2A11 SLC2A10 ABCC5 TXN SLC2A13 HEL-S-25 SLC39A11 SLC39A10 NQO1 SLC5A7 SLC39A13 SLC39A12 SLC39A14 SMVT KEAP1 SLC5A12 MAFG SLC5A10 SLC2A4 ABCC3 ABCC2 MGST3 MGST2 DNAJB1 GSTM4 GSTM3 TGFB1 FTL GSTM2 TGFBR2 EGR1 GPX2 GSTM1 SLC5A2 GPX3 GSTT2 SLC6A20 HEL-75 GCLC ME1 SERPINA1 GSTA5 GCLM SRXN1 NRG1 GSTM5 CES1 SLC6A18 HGF SLC5A8 SLC6A9 TGFA SLC2A3 HMOX1 UGT1A1 HEL-S-22 NFE2L2 CYP2A6 UGT2B7 SLC39A2 SLC39A1 NR1C2 SLC39A3 CYP4A11 ADH7 PTGR1 UGT1A4 UGT1A3 SQSTM1 UGT1A9 UGT1A7 SLC2A12 SLC5A5 EPHA2 RXRA GSTA4 GSTA3 SLC6A11 HEL-S-10 AGER SLC6A19 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260910%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKBIA NFKB1 RELA IKBKB IKBKG THBD HMGB1 AGER CHUK CCL18 SIGNALING%WIKIPATHWAYS_20260910%WP5097%HOMO SAPIENS CCL18 signaling CDH2 CCR8 PTK2B ZEB2 AK4 MMP2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260910%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB CUL5 UBB APOBEC3G RUNX1 ELOC RBX1 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism hCG_1998026 B4GALT4 B3GNT5 FUT1 B4GALT1 NEU2 FUT5 FUCA1 NAGA SIAT4C ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5136%HOMO SAPIENS ALA oxylipin metabolism EPHX2 ALOX15 ALOX5 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260910%WP4249%HOMO SAPIENS Hedgehog signaling BOC CSNK1A1 GPR161 CSNK1A1L hCG_2014051 SPOP GLI3 BCL2 DKFZp686L0365 IHH CCND1 CDON SMURF2 HHIP SUFU KIF3A ADRBK1 EVC2 CSNK1G3 PTCH2 FBXL17 SHH KIF7 EVC SMO SPOPL GAS1 CSNK1G2 CSNK1D SMURF1 CCND2 PRKACG DHH CSNK1G1 PTCH1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260910%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS SLC7A11 PSAT1 PHGDH PSPH DNA REPLICATION%WIKIPATHWAYS_20260910%WP466%HOMO SAPIENS DNA replication UBC MCM3 MCM5 MCM6 PRIM2 PRIM1 CDC45 POLD3 ORC6 POLD4 ORC3 ORC2 POLD2 POLA2 CDK2 RPA1 CDC6 POLA1 POLE2 GMNN RPA3 MCM10 CDT1 DBF4 RPA4 PCNA POLE RFC3 RFC4 RFC2 RFC1 MCM2 MCM7 ORC1L MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260910%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness MFAP5 MAPK3 TNNC1 ITGAV ITGB3 RYR3 PRKCQ JUN MAPK1 PLCG1 CREB1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260910%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 CYP1A2 CYP3A4 SULT1E1 GSTM1 UGT1A3 UGT1A1 UGT1A9 NQO1 SULT1A1 ARSL CYP1A1 STS CYP1B1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP4970%HOMO SAPIENS Galanin receptor pathway CRP POMC INS CDKN1A YAP1 CDKN1B BCL2L11 FOS PPARG SLC2A4 VAMP2 CDKN1C IL6 CREB1 VEGFA ZINC HOMEOSTASIS%WIKIPATHWAYS_20260910%WP3529%HOMO SAPIENS Zinc homeostasis MTF1 MT1F SLC39A2 MT1G SLC39A1 MT1B SLC39A3 MT1E SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT2A SLC39A14 SLC39A9 SLC39A6 MT1M SLC39A5 SLC30A10 SLC39A8 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 SLC30A1 MT4 MT3 MT1A RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260910%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex MED19 MED16 MED18 MED17 GTF2B MED12 MED11 TAF9 POLR2A MED14 MED13 GTF2E2 MED10 POLR2B MED1 POLR2F MED8 POLR2G MED4 POLR2H GTF2F1 POLR2I MED27 POLR2J MED26 POLR2K TBP MED6 MED28 TAF12 MED23 TAF13 MED22 MED25 MED24 CCNC MED21 GTF2A1 CTDP1 MED30 TAF7 MED31 TAF6 MED15 POLR2D POLR2L TAF5 POLR2M TAF10 TAF11 TRFP TAF8 CRSP9 MED9 TAF4 IXL TAF3 TAF1 CDK8 THRA NELFB NELFCD NELFA POLR2C NELFE DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260910%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 DDX1 DGCR8 DROSHA NBN MRE11A ATM TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260910%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production AADAT HAAO NMNAT3 NMNAT2 KMO TDO2 KYNU NMRK1 AFMID NMNAT1 NAMPT IDO1 HEL-S-90n NADSYN1 NMRK2 NAPRT INSULIN SIGNALING%WIKIPATHWAYS_20260910%WP481%HOMO SAPIENS Insulin signaling RAPGEF1 CBL CRK IKBKB SHC3 CAP1 PIK3CD PIK3C2G FOS MAP2K5 VAMP2 MAPK9 MAPK7 MAPK6 MAPK4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 MAP3K12 RPS6KA2 RPS6KA1 EIF4E MAP2K6 MAP2K3 JUN MAP3K1 TSC2 PTPRF MAP3K10 RAF1 MAP3K11 SLC2A4 IGF1R KIF3A IRS1 SHC2 FOXO1 EIF4EBP1 PTPN1 GSK3A PTEN SOS2 INSR MAPK8 SNAP23 RPS6KB2 EGR1 SOCS1 RPS6KA5 TRIB3 MAP3K8 MAP3K14 MTOR GSK3B SHC1 PIK3R2 PIK3R1 FOXO3A SOCS3 MAPK1 INPPL1 RAC1 CBLC MAP3K7 HEL-S-31 RPS6KA4 ENPP1 MAP3K6 MAP4K3 MAPK3 GYG1 INPP4A MAP2K4 STXBP3 MAP4K1 MAP2K1 STXBP4 MAP4K2 RRAD MAP2K2 PPP1R3A STX4A EHD1 RPS6KA6 EHD2 MAP3K13 PTPN11 ARF1 FLOT1 FLOT2 MINK1 SGK2 RPS6KB1 XBP1 GRB2 ARF6 SOS1 SNX26 MAP3K2 HEL-S-42 MYO1C TSC1 PFKM TBC1D4 HRAS SGK1 PRKCI PRKCH GRB14 GRB10 PRKCB RHEB SH2B2 PRKCA GYS2 IRS4 GYS1 PRKAA2 PRKCQ MAP3K5 HEL-S-61 PIK3R4 PIK3R3 RAB4A LIPE PRKCZ SNAP25 STXBP1 PDPK1 PRKAA1 PFKL LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260910%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ELOVL2 ELOVL5 FADS2 ACE2 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260910%WP5293%HOMO SAPIENS Acute myeloid leukemia TCF7L2 TCF7L1 CEBPA RPS6KB2 RELA NFKB1 IKBKB CSF1R PIK3CD STAT5B CHUK CSF2 PIM1 BRAF AKT3 MTOR IL3 RARA PIK3R2 PIK3R1 KIT MAPK1 CCNA2 JUP MAPK3 ZBTB16 MAP2K1 MAP2K2 BAD STAT3 CD14 RPS6KB1 GRB2 SOS1 NR1C2 SPI1 BCL2A1 PER2 CEBPE FCGR1A RUNX1T1 PML NRAS HRAS RAF1 CCND1 MYC RUNX1 ITGAM EIF4EBP1 FLT3 ARAF PIM2 IKBKG PIK3R3 MPO SOS2 LEF1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260910%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase HEL-S-22 EPHX2 COX8A CYP2C9 CYP2J2 COX5A INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260910%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260910%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GIP GCG LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260910%WP5146%HOMO SAPIENS Lung pathology of COVID 19 CXCL11 IRF3 TNF NFKB1 MAVS IL18 RIGI CGAS CCL2 CSF2 TLR8 TLR7 TLR3 IFIH1 CXCL9 TBK1 IL1B MITA IL6 ANGIOGENESIS%WIKIPATHWAYS_20260910%WP1539%HOMO SAPIENS Angiogenesis MMP9 PDGFRA MAPK14 FGF2 TIMP3 FGFR2 HIF1A SRC MAPK1 PLCG1 CREBBP FLT1 SMAD1 KDR ANGPT1 VEGFA SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260910%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 FURIN KDR NRP1 ACE2 VEGFA MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260910%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 KEAP1 NFE2L2 SLC3A2 ATF4 SLC7A5 BASE EXCISION REPAIR%WIKIPATHWAYS_20260910%WP4752%HOMO SAPIENS Base excision repair NEIL2 PNKP UNG POLD3 POLD4 HMGB1 NTHL1 PARP3 TDG ADPRHL2 POLD2 APTX POLG2 TDP1 NEIL1 MUTYH MBD4 PARP4 POLE4 SMUG1 POLG FEN1 POLE2 APEX1 MPG OGG1 POLE3 PCNA POLL POLE RFC3 RFC4 LIG1 RFC2 PARP2 RFC1 NEIL3 MALE INFERTILITY%WIKIPATHWAYS_20260910%WP4673%HOMO SAPIENS Male infertility PEX10 CDC42BPA MLH3 REC8 CTCFL H3-4 SEMG1 XPC TRIP13 BRDT EP300 PMS2 NOS2 SRD5A2 ERCC1 ERCC2 ABCB1 RFC1 DND1 CLU BCL2 NQO1 MDM2 SIRPA ATM NR3A2 TNF APOB MTRR SOX5 SLC46A1 MTR BRCA2 INSR TCN2 SHMT1 PEMT GPX1 HEL-S-61p THBS1 FOLH1 MTHFD1 GNAO1 CYP1A1 MMP2 CYP26B1 MMP9 AGO2 POLG PSAT1 TNFSF6 ETV5 MAS1L CREBBP NFE2L2 KDM3A AHR DAZL MSH5 CYP17A1 CCNK PRDM9 HMGA1 SIRPG HEL110 EPSTI1 SLC16A7 RAG1 NANOS1 FAT10 PRM2 PRM3 SPATA17 MSH4 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 STRA8 MOV10L1 H2BW1 TMEM132E UBE2B XRCC3 TAS2R38 PUM2 H4C9 PIWIL2 PIWIL1 PIWIL4 XRCC5 SPO11 CHD2 HORMAD2 MSMB PRMT6 CDK9 PACRG TEX15 AHRR PON2 PON1 CXXC1 OR2W3 P1 USP26 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP2369%HOMO SAPIENS Histone modifications KMT2E SET SETD4 SETD5 SETD2 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B SUV39H1 DOT1L SETD7 PRDM2 KMT2C SMYD2 SMYD1 KMT5B AEBP2 SMYD4 SMYD3 H4C7 SETDB1 SUV39H2 KMT5C EED SETD1B SETD1A SETDB2 MLL2 SETMAR ASH1L SETBP1 EHMT1 EZH1 H3C8 H4C9 HIST1H4L H3C15 EZH2 KMT2A H3F3B COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260910%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17A IL17RC TLR4 IL17RA SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260910%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCB SPTLC1 PRKCA SGMS2 SGPP1 RB1 DEGS1 TERT KDSR CDKN1A RPP38 MAPK1 CERS2 CDK4 CDK2 PLCB1 SPHK1 S1PR1 UGCG S1PR2 MTOR S1PR5 GLB1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260910%WP3676%HOMO SAPIENS BDNF TrkB signaling GRB2 SOS1 TSC1 RPS6KA1 NTRK2 ARC HOMER1 NRAS TSC2 GAB2 HRAS BDNF BRAF MTOR TRPC3 GRIN1 SHC1 RHEB EIF4EBP1 EEF2K MAPK1 PLCG1 TRPC6 MAP2K1 ADCY1 DLG4 CREB1 RPS6KB1 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260910%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260910%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption CREB3L4 DCTN6 DCTN4 CREB3 ADCY3 ADCY6 ARHGDIG ADCY9 GNAS DYNC2H1 DYNC1H1 VAMP2 RAB5A DYNLL2 DYNC2LI1 AVPR2 DCTN1 DYNC1LI1 DYNC1LI2 CREB3L2 CREB5 DNCL1 DYNC1I1 DCTN5 AQP4 HEL-S-77 AVP AQP2 HEL-S-47e AQP3 RAB5B ARHGDIB RAB5C PRKACG RAB11A STX4A RAB11B CREB1 CREB3L3 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260910%WP5351%HOMO SAPIENS Kleefstra syndrome ACTL6B BAP1 EHMT1 PAGR1 ARID1A NR1I3 SMARCA4 ASH2L SMARCD1 PAXIP1 MBD5 KMT2C SMARCC1 SMARCD2 SMARCC2 RXRA SMARCD3 NCOA6 H3F3B ACTL6A DPY30 ARID1B ASXL1 WDR5 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260910%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA FBL IRF2 HEL23 DDX21 CREBBP FOXO1 MAFG SMAD4 CREB1 NPAS2 IL19 SIGNALING%WIKIPATHWAYS_20260910%WP5422%HOMO SAPIENS IL19 signaling TGFB1 COL1A1 MAPK14 IL20RA TNF TNFRSF1A CCNB1 IL19 NFKB1 CCL11 IL20RB MUC5AC ACTA2 SOCS1 MAPK1 RAC1 SOCS5 IL4 MAPK3 JAK1 STAT1 CXCR4 STAT3 MAPK8 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260910%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway TGFB1 LEFTY1 FST NOG FGF10 NTF4 WNT2B FLT3LG CSF1R GDF5 DKK1 INHBA EPO TPO WNT3A EGF HGF FGF4 TNFSF11 IL11 NODAL FGF8 CNTF IL3 WNT7B FGF2 PDGFA INS SHH KIT NOTCH1 NT5E CXCR1 IL6R TF WNT1 IGF1 ALK BMP4 CSF1 KITLG IL6 VEGFA CREATINE PATHWAY%WIKIPATHWAYS_20260910%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 CANCER PATHWAYS%WIKIPATHWAYS_20260910%WP5434%HOMO SAPIENS Cancer pathways FZD9 CAMK2A FZD8 MSH2 MSH3 FGFR4 FGFR3 FGFR2 CAMK2G FGFR1 WNT2B PIK3CD BDKRB2 GLI3 HEY2 WNT9B WNT9A WNT16 PPARG LRP5 WNT8A WNT8B DLL3 DLL4 MAPK9 WNT7B MAPK10 RB1 CDKN1A CDKN1B BBC3 CASP9 CCND3 CCND2 CASP3 APAF1 DDB2 CCNE2 CCNE1 PMAIP1 GADD45B GADD45A PML CDKN2B GADD45G CDK6 RAD51 CDK4 CDK2 MDM2 BAX CYCS GNA13 FOXO1 ARHGEF1 BCR HIF1A PIM2 CTBP1 ALK CRKL TGFB1 TRAF1 IL2RG NFKB1 TGFBR2 NFKB2 TRAF6 IL2RA IL2RB RXRB RXRG IL12B EDN1 HGF MMP2 IL13 PDGFA TGFA TERT TRAF5 CALML6 CALML3 HMOX1 CALML4 IL5 NFE2L2 PTGER4 IFNA1 ELOC PTGER2 VEGFA PTGER1 PTGER3 ADCY3 ADCY6 PTGS2 ADCY5 GNAI1 NRAS HRAS PLCB3 PLCB4 ADCY9 GNAS PLCB1 PLCB2 CEBPA CBL RELA IKBKB BIRC5 EP300 JAK3 TRAF2 STAT5B CHUK FOS NFKBIA EPO NOS2 PIM1 RARA RARB AXIN2 KIT JUP EGLN1 ZBTB16 EGLN3 EGLN2 KNG1 JUN TPR BCL2 RAF1 Em:AP000351.3 RUNX1 HHIP PTCH2 BDKRB1 KIF7 MGST3 MGST1 MGST2 GSTM4 GSTM3 GSTM5 SKP2 SUFU CCNA2 HEL-S-21 HEL-S-22 SPI1 RUNX1T1 CTNNA1 CTNNA3 CTNNA2 IFNAR2 STAT2 IFNGR2 GSTA4 GSTA3 ITGB1 IFNAR1 ITGA2B ARAF PLCG2 RAC3 ITGAV ITGA2 ITGA6 CRK ROCK1 ROCK2 BRAF IL15 IL3 IL7 IFNA6 TXNRD2 HDAC2 TPM3 FLT3LG TFG DAPK2 EML4 APPL1 IFNA13 IFNA14 NQO1 IFNA16 IFNA17 IFNA10 MAX EVI1 IFNA21 NKX3-1 PLEKHG5 TRAF4 CCDC42 BIRC7 BIRC2 BIRC3 IL15RA VEGFC KLK3 IFNA5 IFNA4 IFNA8 CSF2RA RASGRP4 PLD2 RASGRP3 CCDC6 GNB5 CKS1B ARHGEF11 ARHGEF12 DCC RALB LAMB4 F2 GNAI3 RPS6KA5 LPAR1 ARHA PLCG1 MMP3 CXCR4 CXCL12 TRAF3 PAX8 HEL-S-125m KPG_010 ADCY8 LPAR2 RXRA LPAR3 LPAR4 GNG10 GNG12 GNG11 GNG13 IFNA7 GNGT1 FLT3 GNGT2 IKBKG VEGFB PRKACG VEGFD KITLG CSF3R PDGFRA F2R COL4A2 COL4A1 COL4A4 COL4A6 RET CSF1R CTBP2 GNB2 GNB1 GNB4 GNB3 IL7R HSP90AB1 LAMC2 LAMC1 IL3RA IL13RA1 LAMA5 LAMA1 LAMA4 LAMA3 TGFBR1 EDNRA EDNRB GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 LAMB3 LAMB2 LAMB1 EPOR KEAP1 CCND1 EGF MYC IGF1R FRAT1 ERBB2 FRAT2 SKP1 NR3A2 SHH DVL1 DVL2 DVL3 IL5RA CSF2RB SP1 FLT4 PTEN IGF1 BRCA2 POLK APC2 BMP4 AXIN1 SOS2 BMP2 LEF1 EGFR F2RL3 E2F2 HES1 E2F3 MAPK8 BAK1 CASP8 HES5 TCF7L2 TCF7L1 FADD APC RPS6KB2 GSTM2 GSTM1 GSTT2 GSTA5 IGF2 FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 AKT3 MTOR AGTR1 STAT4 RALBP1 RALA IL12RB1 SMAD2 GSK3B IFNGR1 HDAC1 IL23A PIK3R2 PIK3R1 MAPK1 BCL2L11 RAC1 IL6R CDKN2A MAPK3 JAK1 TNFSF6 NCOA1 COL4A3 COL4A5 MAP2K1 CREBBP ADCY1 MAP2K2 STAT1 BAD STAT3 RASSF1 GNA11 IL6 NTRK1 RPS6KB1 GRB2 ARNT2 SOS1 IL6ST NR1C2 BCL2L1 CXCL8 IFNA2 IL2 IL4 IFNG IL12A FZD10 VHL FH WNT5B PRKCB PRKCA SMO NOTCH2 NOTCH3 NOTCH1 NOTCH4 PIK3R3 WNT1 WNT4 JAG2 WNT10B WNT10A SMAD4 FZD2 FZD5 RBX1 FZD4 MSH6 CAMK2D FZD7 PTCH1 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5102%HOMO SAPIENS Familial partial lipodystrophy CEBPA KLF5 GATA3 STAT5B KLF9 GATA2 PLIN1 MGLL BANF1 KLF2 HEL-S-104 LPL PPARG MAPK9 NR1C1 FNTA PNPLA2 INS PRRX1 LMNB2 CIDEA CIDEC LIPE ICMT LMNA ZMPSTE24 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260910%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment RAPGEF1 CRK IKBKB ROCK1 ROCK2 RTN4R PIK3CD CDC42 CHUK PAK1 NFKBIA MAP2K5 MAPK7 MAPK11 CASP9 APAF1 CREB1 EIF4E NTRK2 JUN MAP3K1 BCL2 RAF1 BAX MYC CYCS YWHAG IRS1 HEL-S-93 EIF4EBP1 EEF2K EEF2 ARHGAP35 PARD3 IQGAP3 NPTX2 WASL PARD6B LINGO1 LEF1 SORT1 KIDINS220 MAPK8 CASP8 TRADD DOCK7 TCF7L2 TCF7L1 FADD RPS6KB2 TRAF6 HEL2 MTOR GSK3B SHC1 ARHA YWHAQ FOXO3A HEL-S-1 MAPK1 BCL2L11 PLCG1 RAC1 MAPK3 HEL-S-47e BMP7 MAP2K4 MAP2K1 TP73 MAP2K2 MAPKAPK2 BAD STAT3 PTPN11 SMPD1 RPS6KB1 GRB2 SOS1 FRS2 HEL-S-15 NRAS BDNF HRAS NGFR PRKCI PRKCH PARD6A CFL2 PRKCB PRKCE SH2B2 PRKCA LIMK1 TIAM1 IKBKG MAP3K5 PRKCZ PDPK1 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling RELA IKBKB PIK3CD CHUK FOS NFKBIA PTPN6 TICAM2 TIRAP TLR1 TLR9 MAPK9 IFNB1 MAPK14 IFNA6 MAPK12 MAPK13 MAPK10 LBP MAPK11 OTUD5 CD14 MAP2K6 MAP2K3 JUN IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 CD40 IFNA21 TNFAIP3 TREM1 CISH IFNA5 IFNA4 IFNA8 TNF TMED7 TIFA SYK BTK IL1B FBXW5 CCL5 CD180 TRAFD1 MAPK8 RNF41 CASP8 SIGIRR RBCK1 LY96 RIPK1 FADD CUEDC2 CD80 TICAM1 MBL2 SFTPD IRAK4 IRAK3 NFKB1 PELI1 ZMYND11 NFKB2 RNF31 SOCS1 PELI3 TRAF6 SARM1 SMAD6 IRAK1 IL12B IRAK2 MAP3K8 MAP3K7IP1 TAB3 MYD88 AKT3 opn PLK1 SFTPA2 PIK3R2 PIK3R1 TLR5 CCL4 MAPK1 RAC1 CCL3 MAP3K7 MAPK3 MAP2K4 MAP2K1 MAP2K2 STAT1 CXCL9 IFNA1 TRAF3 MLST8 IL6 IRF7 CXCL8 IFNA2 SQSTM1 TLR8 IL12A TLR7 TLR4 TLR3 TBK1 IFNAR2 IKBKE CXCL11 IRF3 IFNA7 IFNAR1 CYLD IKBKG PIK3R3 PIK3R5 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKBIA TNF NFKB1 RELA IKBKB IKBKG MUC1 IL6 CHUK NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260910%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY6 ADORA2B ADORA2A P2RY4 P2RY2 P2RY1 LPAR4 LTB4R OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260910%WP3287%HOMO SAPIENS Overview of nanoparticle effects CRP TNF CXCL8 COL4A1 PTGS2 PIK3CD NFRKB LAMA3 PTGS1 HMOX1 BCL2 CCND3 BAX AKT3 IL6 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260910%WP4564%HOMO SAPIENS Neural crest cell migration during development JUN PIK3CD EPHB6 TWIST1 PAK1 EPHB1 EPHB3 BDNF FOS PAK6 PAK4 EPHB2 AKT3 MMP2 NGFR TRIO EPHB4 MMP9 ARHA TIAM1 RAC1 F2RL2 PIK3R4 PIK3R3 PIK3R5 STAT3 ARF1 CDH11 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer CARM1 SLC7A5 GFPT1 RPE HMGCR ME1 PGM3 GNPNAT1 SLC16A4 RPIA SOAT1 DLD BCAT2 CS PDHX HEL-S-32 GLS2 GLUD1 GPT GOT2 DLAT PDHA1 FASN ACLY LDLR HEL-S-30 HK2 PFKL HEL-S-133P LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260910%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB3L4 MAPK14 MAPK12 IL10 MAPK13 NFKB1 RELA REL CREB3 MAPK11 NFKB2 CREB3L2 CREB5 CCL2 TLR4 RELB IL1B ATF4 IL6 CREB1 CREB3L3 CD14 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260910%WP3934%HOMO SAPIENS Leptin and adiponectin ACACA CPT1A LEPR LEP PRKAG1 ADIPOR1 PRKAA1 ADIPOR2 PRKAB1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260910%WP15%HOMO SAPIENS Selenium micronutrient network F2 SELENOP HEL-S-78p F7 CTH RELA NFKB1 ALB SAA1 GPX2 NFKB2 SAA2 GPX1 GPX4 GPX3 CCL2 HEL-75 XDH HEL-S-97n SEPHS2 SELENOO SELENON SELENOM SELENOW SELENOV SELENOT SELENOF SELENOK SELENOI SELENOH CRP PRDX3 PRDX5 HEL-S-2a MSRB1 SELS KMO KYNU TXNRD2 IL6 DIO1 PTGS2 PTGS1 TXN ALOX5 IFNG ALOX15B ALOX5AP TNF INS HEL-S-302 SCARB1 SERPINA3 APOB SAA4 HBB MTR FLAD1 PLAT GPX6 PLG MPO CBS LDLR ABCA1 FGA IL1B INSR HBA2 HEL-S-44 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL33 IL2RG TSLP FCER1G FCER1A MS4A2 CRLF2 IL13RA1 JAK3 OSMR IL4 IL5 IL25 STAT3 TYK2 IL1RL1 IL13 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260910%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAPK14 NFATC1 TNF NFKB1 RELA NR1i1 IKBKB MAP2K6 MAP2K3 PPP3CA IKBKG MED14 MAP3K1 CHUK NFKBIA NR3C1 RXRA SMAD4 PPP3R1 IL6 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAB2 PRKAA2 TJP1 NBPF12 PRKAG1 CHD1L PRKAG2 F11R PYGO1 GJA1 PRKAB1 PYGO2 PRKAG3 AFDN GJA3 BCL9 ACP6 GJA5 GJA8 AMELX TJP3 FMO5 PRKAA1 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260910%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2D LEFTY1 RUNX2 HDAC5 KLF4 LEFTY2 MEF2C MYOD1 EZH2 MEF2B TLX3 STAT3 TLX2 PAX7 TLX1 GIG8 SOX2 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260910%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing ADAR IRF3 MAVS RIGI CGAS RNASEL IFIH1 RNASEH2C RNASEH2B RNASEH2A TREX1 MITA IFNB1 RNASET2 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies DHODH IFNG TNF ITGB7 F2RL1 ITGA4 EGFR IL-21 IL2 IL15 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260910%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer ENO1 HK3 HEL-S-68p ALDOB SLC16A3 HEL-S-162eP TIGAR HEL107 PAICS ACO2 PGAM1 SDHB RPIA MDH2 FH GLS SUCLG2 GLUD1 GOT2 PSAT1 PDHA1 FASN PSPH PYCR2 ACLY HEL-S-51e HEL-S-30 PFKL HEL-S-133P NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260910%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway ATG101 PLA2G6 ATG2A FTL TSC1 PANK2 ATG3 WDR45 DCAF17 RB1CC1 C19orf12 ATG10 CP WIPI1 COASY ATG12 AKT1S1 WIPI2 FA2H TSC2 ATG16L1 MTOR MAP1LC3A SPTLC1 RHEB ACACA DEPTOR PIK3R4 ATG14 RPTOR ULK1 MLST8 PRKAA1 DKFZp686F0183 STK11 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260910%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CAMK2A NRXN3 NRXN2 MAPK14 NCAM1 DRD1 CALM1 PRKCA NGF RPS6KA1 HNRNPL CAMK4 MAPK1 RPS6KA5 SYT2 CAMKK1 BDNF BCL2 CCND2 CAMKK2 PRL PPARGC1A CREB1 NRXN1 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260910%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CMA1 HEL-S-130P REN CTSG MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260910%WP2003%HOMO SAPIENS miR targeted genes in leukocytes IFRD1 PTPA ATP2A2 CAP1 PHC2 IGF2R TXN2 PISD SRSF10 USP1 RDH10 MAPK14 POLE4 PLXND1 MCL1 HEL-S-66 LMNB2 CHORDC1 PNP VPS39 CDK5RAP3 GOLGA7 SLC7A11 ATP6V0E1 TPM3 SNX6 SFXN1 POM121 TMED10 BCL2 MRPL20 CDK6 TMED3 ATP6V1F CTSC TBCA SLC7A6 CDCP1 FRG1 ARF4 TRAM1 ADAR SHOC2 PPIB CA12 MRC2 SPTLC1 SH3BGRL3 ANXA2 GNA13 ARHG WDR11 PRPF40A LAMTOR3 TUSC2 ARID4B ADIPOR2 DNAJB1 POLR2C RAB5C SLC1A4 CORO1C DDX5 CD164 AP3D1 BRPF3 ARCN1 SLC25A1 FMNL2 SNAP23 FADS1 TNFAIP2 CDIPT TMEM109 ACP2 SCYL1 RFT1 THBS1 TYMS HEL-S-26 MTHFD2 LPL MAP3K8 MPDU1 ANAPC1 CEBPB YWHAQ HMOX1 HEL-S-47e BCL6 TUBA1A TNLG5A TMEM43 SERPINE2 DCAF7 KCNN4 SAC3D1 MENT HMGA1 ADPGK PRSS21 PTRH1 UNC93B1 GYS1 NELFCD PPIF RTN4 HEL-S-30 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260910%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R2 PIK3R1 MAPK1 PIK3CD PIK3C2G NRAS PIK3C2B PIK3R4 HRAS MAPK3 PIK3R3 RAF1 PIK3R5 EGFR ERBB2 ERBB3 AKT3 ERBB4 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260910%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway NCKAP1L FCGR1A C1QC PIK3CD C1QB PTPN6 C1QA NCF1 ARPC1B NCF4 TREM1 CYBA SIGLEC7 NCF2 ITGAM PIK3R2 FCER1G PIK3R1 RAC1 LYN CYBB SYK LAT PIK3R3 PLCG2 RAC3 TYROBP VAV3 VAV1 VAV2 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260910%WP430%HOMO SAPIENS Statin inhibition of cholesterol production CYP7A1 DGAT1 HMGCR APOA2 APOC3 LPL SOAT1 APOA4 APOA5 PDIA2 LIPC ABCG8 APOC2 ABCG5 SQLE PLTP APOC1 MTTP FDFT1 ACSS1 SCARB1 APOB APOE LDLR ABCA1 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260910%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CEBPA FGFR4 ARID1A EP300 UHRF1 FOXO3A NCOR1 ARID5B CHEK2 CREBBP CHEK1 MAP2K2 TLK1 SMC1A KDM6B SMARCE1 BCORL1 SETD2 HRAS RAF1 MAX KMT2C SRCAP MYC ERBB2 ATM FBXW7 JMJD1C MYB HIST1H1E MYBL1 BCOR CMTR2 MAGI1 HIST1H2AK INSRR FOXP2 MORF4L1 KAT6A MAML3 MYCBP ARID4B DTX4 NOTCH1 MGA PRKDC CTBP1 FGF16 KANSL1 NFIB PTEN ERBIN NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260910%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 HEART DEVELOPMENT%WIKIPATHWAYS_20260910%WP1591%HOMO SAPIENS Heart development PITX2 FOXH1 NFATC2 BMPR1A FGF10 BMPR2 TBX20 HEY2 NKX2-5 MEF2C IRX4 TBX5 SMYD1 ISL1 HAND1 FGF8 VEGFC GATA6 NFATC1 SHH MAPK1 NOTCH1 FOXA2 TBX1 BMP10 TBX2 HAND2 VEGFB NFATC3 NFATC4 GATA4 BMP4 SMAD1 BMP2 SMAD4 PTPN11 BHLHB2 ERBB3 FOXC2 FOXC1 VEGFA NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260910%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD MACROPHAGE MARKERS%WIKIPATHWAYS_20260910%WP4146%HOMO SAPIENS Macrophage markers CD74 CD163 CD83 LYZ CD68 F3 CD14 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260910%WP4504%HOMO SAPIENS Cysteine and methionine catabolism GCLC CBS CTH HEL-S-64p pcap ETHE1 SQOR HEL-S-61p SUOX CDO1 MAT1A MTR SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260910%WP4496%HOMO SAPIENS Signal transduction through IL1R TGFB1 IRAK3 RELA NFKB1 IKBKB MAP2K6 MAP2K3 TRAF6 JUN MAP3K1 IL1R1 CHUK IL1A NFKBIA ECSIT IRAK1 IRAK2 MAP3K7IP1 MAP3K14 MYD88 IFNB1 MAPK14 TNF MAP3K7 IFNA1 IL1B IL1RN MAPK8 IL6 TRANSLATION FACTORS%WIKIPATHWAYS_20260910%WP107%HOMO SAPIENS Translation factors EIF4EBP3 EIF3E EIF2B1 EIF2AK2 EIF3F EIF4G1 EIF2B5 EIF3D EIF5A EIF3A EIF5B EIF3B EIF2B3 EIF2S1 CLUH EIF1AY EIF4E EEF1G EIF6 EEF1A2 PAIP1 ETF1 EIF2AK1 EIF2B2 EIF4EBP1 EIF4A1 EEF2K EEF2 PABPC1 EEF1A1 EIF1AX EIF2S2 SUI1 EIF4B EIF3S3 EIF5 EIF2S3 EIF4A2 EIF4EBP2 EIF3S2 GSPT2 EIF3J EEF1B2 EIF3G EIF4H EIF3CL BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260910%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CAMK2A CDH2 EIF2S1 RELA IKBKB SHC3 SRC FRS3 DOK5 STAT5B CDC42 KCNN2 CHUK RAP1A DOCK3 KCNA3 NFKBIA NTF3 SH2B1 MAP2K5 RANBP9 MARCKS MAPK9 MAPK7 NCF2 MAPK14 MAPK10 NGF CASP3 NCK2 CREB1 KSR1 RPS6KA1 EIF4E NTRK2 JUN MAP3K1 TSC2 PTPRF SYN1 RAF1 CDK5 CRTC1 SIRPA CSNK2A1 RPS6 IRS1 NCAM1 SHC4 ARHG SHC2 EIF4EBP1 PTK2B GRIP1 ACACB EEF2 EIF2S2 GRIA2 LINGO1 SORT1 KIDINS220 CNR1 MAPK8 FYN APC NFKB1 TRAF6 RPS6KA5 MEF2C IGF2BP1 GRIA3 MTOR GSK3B SHC1 PIK3R2 PIK3R1 FOXO3A MAPK1 PLCG1 RAC1 NCK1 MAPK3 MAP2K1 MAP2K2 RASGRF1 STAT1 BAD STAT3 PTPN11 NTRK1 RPS6KB1 GRB2 NTRK3 GRIN2B MAP3K2 FRS2 HEL-S-15 SQSTM1 BDNF HRAS CAMK1 NCF1 GABRB3 CDKL5 NGFR GRIN1 SH2B2 CDK5R1 TIAM1 PRKAA2 IKBKG CAMK4 ADAM17 PPP2CA NFATC4 YBX1 VAV3 CYFIP1 PDPK1 PRKAA1 VAV2 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260910%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction TNF IFNAR1 TNFRSF1A NFKB1 IFNA1 ACE2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C18 CYP2B6 CYP2C9 CYP2C19 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260910%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis SREBF2 NR1H3 SIRT6 HMGCS1 FASN HMGCR SIRT1 SCD LDLR ABCA1 PPARGC1A PRKAA1 NR1C1 MTOR MED15 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260910%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC3 SLC51A SLC51B ABCC2 ABCB1 FABP6 SLCO1B1 ABCB11 SLC10A2 NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP61%HOMO SAPIENS Notch signaling NFKB1 EP300 SRC PSENEN NUMB HEY2 MAML2 MAML1 DTX1 RBPJ MAGEA1 DLL3 CIRSR DLL4 SPEN RING1 SAP30 SKP1 FBXW7 MTOR HES6 GSK3B FHL1 ITCH HDAC1 PIK3R2 SNW1 PIK3R1 NCOR1 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 HDAC2 ADAM17 JAG2 NCOR2 PSEN2 STAT3 PSEN1 HES1 APH1B HES5 LCK GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260910%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells INS GCG GLP1R IL6 SLC2A2 IL6R DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260910%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets IKZF1 SPI1 RUNX2 FLT3LG IRF4 IRF8 CSF2 TCF4 TPO STAT3 CSF1 GIG8 BATF3 P38 MAPK SIGNALING%WIKIPATHWAYS_20260910%WP400%HOMO SAPIENS p38 MAPK signaling TRADD MEF2D GRB2 RIPK1 ATF2 MAP2K6 TRAF2 MAP3K1 CDC42 RPS6KA5 DDIT3 HRAS MAX MYC HMGN1 MAPKAPK5 MAPK14 SHC1 RAC1 MAP3K7 MAP3K5 HEL-S-102 TGFBR1 MAP2K4 RASGRF1 STAT1 MAPKAPK2 SMIM40 CREB1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260910%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling CARD11 ACTG1 C1QBP CPN1 PS1TP5BP1 DKFZp781O1323 PMPCB GTF2F2 IFNB1 IL7 HLA-DRB1 NRF CD3G PRG3 CD3E PITRM1 CD2 LBP CASP9 CASP3 CCNB2 CCNB1 CDC2 CFB C1S CFH MOV10 HEL-S-130P CFI RPS6 ZAP70 ITCH EIF4EBP1 HIF1A HBB TF FGA CCL5 FYN HEL-S-78p RRAS ALB SAA1 TGFBR2 SAA2 NFKB2 SELP TRAF6 PF4 CCL2 IL1R2 APOA2 IRAK1 MYD88 IL13 RRM2 CEBPB CCL4 CCL3 MMP25 APOL1 IL5 RPTOR CXCL9 CXCL12 ULK1 COQ8B TRAF3 AHR MLST8 NLRP3 IL17A PTGS2 AKT1S1 IGLL1 DDIT4 IFIH1 TPO TBK1 APOC1 IRF3 RHEB MAVS TBKBP1 IKBKG RIGI OAS2 CCR6 CD163 EIF4A2 RTN4 CCL1 APOD IL33 CCL20 BIRC5 TRAF2 FOS PTPN6 HEL117 TNFSF10 TRPM2 GTSE1 CXCL16 VPS36 VPS18 WDR74 CFP LARP1 APOM APOH VPS16 HEL103 INTS4 HRG CTSZ SERPINA10 HBD SDF2 HEL-S-72p GP1BA IL16 HMFT1766 IL8RB IFI6 OS9 CCL15 MIB1 CCL27 CCL26 CD14 SRP19 STEAP3 HEL-S-81p HP IFITM3 CLCC1 IFITM1 TLE3 VPS33A ADAM9 UGCGL2 G3BP2 EIF4E NPTX1 MDN1 JUN FAM83A NEK9 BST2 GGH IFI27 TP53I3 LGALS3BP CXCL6 CXCL3 CXCL5 TRO TRIM59 ITIH4 ITIH3 CCL8 ATE1 VPS41 ATP13A3 CCR5 FAM98A CASP5 CXCL1 FGF2 TNF CXCL2 DEPTOR CXCR1 IL1B NLRP1 MAPK8 CASP8 EGR1 IL22 IL-21 IL18RAP MTOR ACE2 CRP CTSL RAC1 JUNB JAK1 STAT1 IL6 NTRK1 IL10 GABARAPL2 CXCL8 CCL11 IL18 CXCL13 C8A DKFZp762B153 CCL22 IL4 IL1A IFNG IL12A CD226 HLA-DRB5 MX1 CCL21 IFIT1 IL9 PIAS1 IRF9 PRKCQ CAMK4 NFATC3 SRP54 SMAD1 PARP2 TOMM70 CD8B CD8A LCK ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer RAPGEF1 MSH2 ATF1 CRK EIF4E1B DOCK1 PXN PAK1 RAP1A CPN1 FOS HSD3B2 HSD3B1 HSD17B3 HSD17B7 MAPK14 RB1 CDKN1A CDKN1B CASP9 CHEK2 CASP3 SMARCD1 CHEK1 SMARCC1 SMARCD2 SMARCC2 SMARCD3 ACTL6A ARID1B JUN MRE11A TSC2 CDC2 CDKN2B BCL2 RAD50 RAF1 CDK4 CDK2 CCND1 MDM2 BAX MYC SPINK1 FKBP5 ATM BLM BARD1 ATR KLK3 NOXA1 FOXA1 RICTOR SPRY2 SPRY1 F13B EIF4EBP1 PTK2B SP1 PTEN ERG CRKL MAPK8 CASP8 HSD17B2 ARID1A HGF CDC25B MTOR SMAD2 PLK1 MAPK1 MAPK3 CDKN2A JAK1 MAP4K1 MAP2K1 MAP2K2 RPTOR STAT1 BAD STAT3 PTPN11 GRB2 ACTL6B SOS1 TSC1 CYP17A1 HRAS HSD17B4 HSD17B1 RHEB SMARCA4 PRKDC ETV4 MSH6 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2853%HOMO SAPIENS Endoderm differentiation BMPR1A TOX SOX17 CER1 C1QBP CTBP2 SOX7 WNT8A NR1B3 GATA6 LAMC1 TAF5 ELAVL1 SFRP1 OTX2 ZFHX4 PBX1 CUL4B SESN1 EZH2 GATA4 LHX1 CEBPZ EXT1 SOX2 TCF2 PAX3 MAP2K3 DKK1 TOX3 CRTC1 BPTF FOXA1 WWC1 HOXA1 SFMBT1 ACACA CDYL FOXO1 RFX7 RAB38 CTR9 PRDM14 RTF1 SIAH2 FOXN3 SP4 FOXA2 PAF1 TAF4B ONECUT1 HOXC11 TCF4 CDC73 HHEX DUSP4 DUSP5 DUSP2 Pax9 LEF1 BTAF1 PTHLH TCEAL2 LEO1 KDM4A LRPPRC TNRC6C TCF7L1 TGFB1 NKX2-1 APC NOG FOXH1 CAND1 DNMT3B POU5F1 WNT3 MIXL1 NODAL TBX21 SMAD2 NLK APP BMP7 PABPC1 MAD2L2 SOX21 STAT1 CEP250 WDHD1 EMSY WDFY2 BCORL1 MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 GDF3 NABP2 TRIM71 BCAR2 PHF6 ZIC3 TRIM5 JARID2 SLC2A12 TET1 PARP8 AEBP2 AHDC1 ZNF462 ELP4 ZIC5 RGS10 PIAS1 NOTCH1 NR3C1 VAV3 SMAD4 PLCH1 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260910%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation IRF3 MAVS TBK1 TRAF6 RIGI TRAF3 TOMM70 IKBKE IFNB1 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation RHBDD2 TMEM120A SSC4D STYXL1 HEL163 ZP3 KIF1C ZP2 SFN DAPK2 HEL-S-102 RAF1 MDH2 LMNA SRRM3 POR YWHAG PTPMT1 TMEM120B EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260910%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 XDH COX1 AOX1 HBA2 HBB NRF2 ARE REGULATION%WIKIPATHWAYS_20260910%WP4357%HOMO SAPIENS NRF2 ARE regulation GSK3B CEBPB SLC7A11 PRKCA AIMP2 PGAM5 SRC HMOX1 NQO1 GCLC MAF GCLM KEAP1 NFE2L2 YES1 EPHB2 INSR RBX1 MAPK8 FYN ROTENONE METABOLISM%WIKIPATHWAYS_20260910%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway ANKRD1 CCL20 SNAI2 TGFBR3 EPB41L4B NFKB2 ARL5B RGS2 ENC1 TNS4 SRGN CCL2 FGFBP1 EDN2 TSC22D3 NAV3 ADGRF4 CDC42EP3 SCNN1A PMP2 MFGE8 POU5F1 SLC26A2 ABHD2 PRRG4 GPR153 SERTAD2 STOM IL11 ANGPTL4 MGAM PPP1R14C CAVIN2 PTGES3 PLK2 DNAJC15 KTN1 S100P CPEB4 B3GNT5 ACKR3 CDKN1C GADD45B PTGS2 JUN ZIC2 ALOX5AP TNFAIP3 RXRA THBD SLC19A2 BIRC2 AMIGO2 BIRC3 DNER SPRY1 NR1I3 NR1i2 PDE4B NR3C1 FGD4 BHLHB2 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260910%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells CYP2B6 CYP2A6 UGT1A4 AOX1 UGT1A9 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260910%WP5061%HOMO SAPIENS Fatty acid transporters FABP9 ACSL6 ACSL5 FABP5 ACSL3 FACL4 CD36 DBI HEL-S-104 FABP6 FABP1 SLC27A4 FABP2 ACSL1 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260910%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy SLC16A3 RPS6KA2 RPS6KA1 GPX4 NAMPT PFKFB2 HEL-75 RAF1 DLD BRAF PPARGC1A MTOR GLS PKLR HEL-S-281 ACSS1 CPT1A DLAT ARAF PDHA1 HEL-S-304 MAPK1 MAPK3 MAP2K1 RPTOR MAP2K2 MLST8 HEL-S-30 HEL-S-133P SPINAL CORD INJURY%WIKIPATHWAYS_20260910%WP2431%HOMO SAPIENS Spinal cord injury COL4A1 ROCK2 RTN4R CDC42 GJA1 FOS NOS2 PLXNA2 RB1 CSPG4 CDKN1B APEX1 NTN1 AQP4 XYLT1 CASP3 GDNF GADD45A RGMA IL1R1 CDC2 C1QB CDK4 CCNG1 CDK2 COL2A1 CCND1 MYC HEL113 CXCL1 TNF ARG1 CXCL2 MBP SOX9 EPHA4 OMG GAP43 CHST11 EFNB2 IL1B EGFR TGFB1 PLA2G2A EGR1 SELP CCL2 AQP1 FKBP1A CCR2 LTB4R MMP9 ARHA FOXO3A ZFP36 MAPK1 SEMA6A RAC1 PDYN BCAN KLK8 TNFSF13 MAPK3 BTG2 NCAN PRB1 E2F5 PRB2 RHOB ANXA1 TACR1 VCAN LTB MMP12 ACAN SLIT1 TNLG7A SLIT3 LILRB3 IL6 FCGR2A PLA2G5 PLA2G6 NOX4 CXCL8 PPP3CA PTGS2 LEP IL2 GFAP IL4 BDNF IL1A IFNG TLR4 NGFR GRIN1 PRKCA SLIT2 ROS1 CD47 RTN4 AIF1 INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260910%WP4558%HOMO SAPIENS Interferon mediated signaling IFNL1 IFNL4 IFNL3 IFNLR1 IFNW1 IL10RB IFNA2 IFNA13 IFNA14 IFNG IFNA16 IFNA17 IFNA10 IFNA21 IFNAR2 STAT2 IFNGR2 IFNB1 IFNA5 IFNA4 IFNE IFNA8 IFNK IFNA7 IFNA6 IFNGR1 IRF9 IFNAR1 PRKCA PIK3R1 JAK1 STAT1 IFNA1 TYK2 IFNL2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260910%WP47%HOMO SAPIENS Hedgehog signaling SUFU SIN3A ADRBK1 PTCH2 SAP18 DHH SHH IHH KIF7 SMO GLI3 PTCH1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260910%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain NFKB1 ARHA MAP2K6 MAP2K3 YAP1 MAPK1 RAC1 MAPK3 RAF1 MAP2K4 MAP2K5 MAP2K1 MAP2K2 AMOT MTOR TRIO VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260910%WP3871%HOMO SAPIENS Valproic acid pathway IVD CYP2B6 ABAT HDAC1 CYP2A6 EHHADH HSD17B10 ACADSB CYP2C9 HADHB LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260910%WP3935%HOMO SAPIENS Leptin insulin signaling overlap IRS1 SOCS2 INS IRS4 SOCS1 SOCS3 LEPR DGKZ LEP PIK3R3 STAT3 PDPK1 INSR AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260910%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension GLUD1 HAL UROC1 GPT2 FTCD CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy GRB2 IRS1 ITGB4 INS DGAT2 CAVIN1 HIF1A DGAT1 BSCL2 LPIN1 LPIN3 LPIN2 HMFN0839 FYN ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RAPGEF1 FBP1 CBL CRK SHC3 CAP1 PIK3CD PIK3C2G PCK1 MAP2K5 ABCG8 ABCG5 MAPK9 MAPK7 MAPK6 SREBF2 MAPK4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 MAP3K12 CYP3A4 RPS6KA2 RPS6KA1 EIF4E MAP2K6 MAP2K3 MAP3K1 TSC2 MAP3K10 RAF1 MAP3K11 SLC2A4 RICTOR IRS1 SHC2 FOXO1 EIF4EBP1 INS PTPN1 MLXIPL FASN GSK3A CYP2B6 SOS2 INSR MAPK8 RPS6KB2 RPS6KA5 LPL MAP3K8 SCD MAP3K14 ANGPTL8 MTOR GSK3B SHC1 PIK3R2 PIK3R1 FOXO3A MAPK1 CBLC MAP3K7 HEL-S-31 RPS6KA4 MAP3K6 THRA MAP4K3 MAPK3 G6PC1 MAP2K4 MAP4K1 MAP2K1 MAP4K2 MAP2K2 RPTOR RPS6KA6 MAP3K13 FLOT1 MLST8 FLOT2 SLC16A2 MINK1 RPS6KB1 SOS1 MAP3K2 HEL-S-42 NR1H3 TSC1 SLCO1C1 CYP7A1 SESN3 MAPKAP1 EXOC7 TRIP10 HRAS NR1A2 RXRA RHEB PRKAB2 IRS4 GYS1 PRKAA2 PRKAG1 MAP3K5 PRKAG2 PRKAB1 PIK3R4 PRKAG3 PIK3R3 PDPK1 PRKAA1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260910%WP4352%HOMO SAPIENS Ciliary landscape IQCB1 RBM14 CAMK2A RAB2A MSH2 CNOT6L EIPR1 EIF5B RAB3IL1 ARFGAP3 RABEP2 NME8 EXOC4 EXOC3 EXOC5 CEP170 EFHC2 MAPRE2 CCDC40 EXOC1 SNRPB2 IFT70B IFT70A CTBP2 WDR26 HEL-S-91n ANKS3 VPS4A RANBP9 USH1C RAB21 PAFAH1B1 RMND5B DNPEP PGRMC2 RMND5A MKLN1 GID4 MFAP1 VAPB GID8 YPEL5 HTRA2 CLUAP1 RB1 ACSL3 TFAP2A TFAP2C BBS4 HDAC2 NUP133 XPNPEP3 MKS1 MCM7 RAB14 MCM3 MCM5 MCM6 ECHS1 NUP88 POM121 WEE1 EXOC6 NDUFA9 HEL113 SSNA1 NDUFA5 GLB1 GLA DVL3 MCM10 RALB IQGAP3 IFT172 CBS DDX5 IFT74 DOCK5 LRPPRC RHBDD2 COPS6 NUDC APC SNAP29 NFKB1 NEF3 RQCD1 STOM EXOC8 BBS9 BBS7 EXOC2 CEP97 HDAC1 BBS5 CEP290 YAP1 RAC1 PSMD7 HEL-S-47e CREBBP BBS2 NEK8 LCN2 BBS1 TTC8 CALM1 TBC1D4 CD2BP2 EXOC7 DGKE TRAF3IP1 DCAF7 UBE2D2 SMC4 MAEA APMAP ARMC8 LZTFL1 NEFL MYL6 DYNC2I2 TIPRL ERF UQCC DYNC1H1 ARL8B DYNLT1 INTU IFT140 COPS7A DYNLT3 IQGAP1 DYNLT2B IFT80 HEL-S-296 CDH23 DYNLL2 CDR2 AAR2 DYNC1LI1 CTSA PSMC6 TFAP2B IFT22 PSMC4 UBE2H TFAP2D IFT43 IFT81 TFAP2E EXOC6B IFT27 CNOT10 DYNLRB2 FUZ DNCL1 BBIP1 RAB8A IFT46 LSM4 COPS4 IFT25 IFT20 EHD3 COPS5 CNOT1 WNK1 RANBP10 COPS8 EXOSC4 PSMD12 TTC26 PSMD13 GDI1 ZMYND19 MCM9 MYL6B RPGR H3F3B IFT52 TMED1 MCM2 IFT57 DFNB31 NINL ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260910%WP1993%HOMO SAPIENS Angiogenesis overview F2 APC ATF2 CRK FGFR1 SRC PIK3CD PXN CDC42 PAK1 DAG1 KDR MMP2 MTOR ROBO4 MMP9 SHB ROBO1 MAPK14 TIMP4 SHC1 WAS BMX MAPK11 PLXND1 MAPK1 RAC1 NCK1 PLCG1 MAP3K7 MAP2K4 MAP2K1 BAD PTPN11 MMP14 VEGFA GRB2 SOS1 FRS2 NOX4 MAP2K6 RAF1 VHL ANGPT1 IQGAP1 GRB14 GRB7 PRKCA PTK2B PLA2G1B SLIT2 SEMA3A PDPK1 MAPK8 NRP1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5365%HOMO SAPIENS 4p16 3 copy number variation GRB2 SOS1 FRS2 CBL FGFR3 CLTCL1 FGF2 ERI1 SLBP PIK3R1 NSD2 TMEM129 FAM53A MAPK1 POLN UBE2J2 PLCG1 CKAP5 LETM1 NICOL1 NELFB TACC3 NELFCD MAPK3 NELFA NELFE H3F3B NAT8L EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260910%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TRADD CCL20 TRAF1 TNF CXCL8 NFKB1 RELA IKBKB NFKB2 TRAF6 IKBKG MAPK1 MAP3K7 CHUK NFKBIA PDLIM7 IRAK1 CCL5 MAP3K14 MAPK8 IFNB1 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260910%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection XBP1 PPP1R3E EIF2AK2 PPP1R1C PPP1R1B PPP1R14A PPP1R3D PPP1R14D EIF2S1 PPP1R15A HEL-S-89n DDIT3 BCL2 EIF2AK1 PPP1CC PPP1R14C MAP1LC3A HEL-S-80p MBTPS1 PPP1R12C MBTPS2 PPP1R15B PPP1R13B ERN1 PPP1R11 PPP1R7 PPP1R10 sm-M20 PPP1R9A PPP1R3A PPP1R2 PPP1R8 PPP1R16B PPP1R14B PPP1R16A PPP1R3G ATF4 PPP1R3F MAPK8 PPP1R1A PPP1R3C PPP1R3B FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes LIPA STARD3 SOAT2 SLC27A3 LPA SLC27A1 DBI HEL-S-104 STAR SOAT1 APOA4 FABP1 SLC27A4 APOC2 FABP2 APOC1 PCSK9 MYLIP ACSL6 ACSL5 SCARB1 APOB ACSL3 APOE LDLR NPC2 ABCA1 SORT1 SLC27A2 ACSL1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260910%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IRF7 EIF2AK2 IRAK4 TREML4 TMPRSS2 TRAF6 TLR7 TLR4 TLR3 IFIH1 TLR9 TBK1 IFNAR2 STAT2 MYD88 IKBKE ACE2 IRF3 IRF9 IFNAR1 MAVS RIGI OAS2 OAS3 JAK1 STAT1 TYK2 TRAF3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260910%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation NKX2-5 MEF2D MEF2C CCND2 MEF2B MYOCD KLF4 CAMK2D ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260910%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling GRB2 SOS1 ITGA6 SRC HRAS MTOR LAMC2 LAMC1 IRS1 MAPK14 SHC1 ITGB4 EIF4EBP1 PRKCA ARHA PIK3R2 PIK3R1 LAMA5 LAMA1 MAPK1 RAC1 LAMA3 MAPK3 LAMB3 PTPN11 LAMB2 LAMB1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP357%HOMO SAPIENS Fatty acid biosynthesis ACACA ACSL6 ACSL5 ECHS1 ACSS2 FASN PECR ECHDC1 ACSL3 ECHDC2 FACL4 ACACB DECR1 ACLY PC MECR SCD ACSL1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5402%HOMO SAPIENS 10q22q23 copy number variation MAS1 CEBPA NFKB1 ZMYND11 BMPR1A OPN4 SMC3 ROPN1L PPARG RSPH6A DNAJB13 GLUD1 DYDC1 RAD21 STAG1 RSPH14 MAD2L2 IQUB NRG3 SMC1A ERBB4 NME5 VEGFA RSPH9 SIRT4 SH2D4B RSPH3 FAM25A BUB1B ADIRF LDB3 GHITM WAPAL CDHR1 MMRN2 DYDC2 RGR PDS5B PDS5A GPR15LG SNCG TNFSF11 SUSD2 TSPAN14 ADAM10 RSPH1 LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 CCSER2 SH3GL3 ACTN2 BMP2 MAT1A SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260910%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides B4GALNT1 A4GALT A3GALT2 SPTLC1 SGMS2 CERS3 CERS5 CERS6 KDSR B4GALT1 CERK DGAT1 LASS1 CERS2 SGMS1 B3GNT5 DES SPHK1 UGT8 UGCG AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5531%HOMO SAPIENS AKT signaling and ARTD family members TSC1 PIK3CD MAPKAP1 PIK3C2G PARP3 TSC2 PIK3C2B SIRT1 AKT3 ATM MTOR RICTOR GSK3B FOXO1 PIK3R2 PIK3R1 IKBKG PHLPP1 PIK3R4 PIK3R3 PIK3R5 RPTOR PARP2 MLST8 STK11 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260910%WP12%HOMO SAPIENS Osteoclast signaling opn CTSK IFNAR1 AIMP2 ITGB3 TNFRSF11B TRPV5 ACP5 ATP6V1G1 GPR68 MAPK8 TNFSF11 TNFRSF11A IFNB1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260910%WP1455%HOMO SAPIENS Serotonin transporter activity TPH2 TGFB1I1 STX1A MAOA ITGB3 IL1B IL1R1 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2064%HOMO SAPIENS Neural crest differentiation CDH6 TCF7L1 CDH2 SNAI1 SNAI2 FGFR3 NFKB1 FGFR2 NFKB2 FGFR1 TWIST1 HEY2 CTBP2 HDAC10 ISL1 FZD3 WNT3A WNT8A DLL3 DLL4 GSK3B AXIN2 HDAC1 TFAP2A NEUROG1 HDAC2 HDAC3 BMP7 RHOB TLX2 PAX7 LHX1 DLX5 PAX3 ID1 MSX1 GFAP COL2A1 HAND1 RBPJ MYC FGF8 ZIC5 MYB ITGB1 ASCL1 FGF2 HOXA1 TFAP2B TBX6 DVL1 DVL2 MBP SOX9 DVL3 NOTCH2 HDAC5 SOX5 NOTCH3 HDAC11 NOTCH1 HDAC8 DMBX1 HDAC7 ZIC1 NOTCH4 FOXD3 FGF19 MSX2 COL11A2 MIA OLIG1 OLIG3 OLIG2 TCF4 DCT WNT1 SOX10 HOXB1 PRTG AXIN1 GBX2 BMP4 SMAD1 PHOX2B GJB1 MPZ LHX5 PMP22 HES1 HES5 FERROPTOSIS%WIKIPATHWAYS_20260910%WP4313%HOMO SAPIENS Ferroptosis IREB2 DPP4 FTMT PCBP1 FTL PHKG2 PRNP CTH HEL-S-64p LPCAT3 SLC3A2 GPX4 SLC38A1 HMGCR GCLC GCLM POR MAP1LC3A FDFT1 ACSL6 ACSL5 ACSL3 HMOX1 FTH1 SLC39A8 VDAC3 COQ2 BACH1 DKFZp686F0183 MAP1LC3C STEAP3 NOX4 SLC7A11 ALOX15 CP DKFZp762B153 AKR1C1 AKR1C2 TFRC SLC39A14 SLC40A1 FACL4 HEL-S-102 CYBB TF CBS CISD1 SAT2 AIFM2 CHMP6 ACSL1 SLC11A2 CHMP5 NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP268%HOMO SAPIENS Notch signaling RBPJL DTX2 DTX3 LFNG KCNJ5 MFNG NUMB CTBP2 KAT2A MAML1 DTX1 RBPJ DLL3 DLL4 HDAC1 DVL1 DVL2 DVL3 MAML3 NOTCH2 NOTCH3 DTX4 NOTCH1 CTBP1 NOTCH4 HDAC2 ADAM17 CREBBP JAG2 NCOR2 PSEN2 KAT2B PSEN1 HES1 APH1B DTX3L HES5 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260910%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC CYR61 TEAD2 ARHA PRKAB2 PRKAA2 YAP1 PRKAG1 MOB1A PRKAG2 STK4 LATS2 RHOD PRKAB1 PRKAG3 RHO HMGCR TEAD3 TEAD4 CTGF RHOB LATS1 PRKAA1 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome CUL5 SMAD9 ATF2 DDX21 SIRT6 MYO1C NOG BMPR1A MYBBP1A JUND GDF5 PARG SLC18A3 LRRC18 BCL2 RIF1 DKFZp781O1323 OGDHL ARHGAP22 SIRT1 EIF4ENIF1 HSF1 DLD HSF4 FAM170B CEFIP VSTM4 MEN1 DRGX KDM4D C10orf53 SMARCA5 DEK RGMB BAZ1B TMEM273 ITCH UVSSA WDFY4 ChAT PCNA ERCC5 SMAD1 SMARCC2 BMP2 ELOA MAPK8 NLRP3 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260910%WP134%HOMO SAPIENS Pentose phosphate metabolism RPE RPIA HEL107 HEL-S-304 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260910%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CD80 CD3D RELA NFKB1 IKBKB GRAP2 PIK3CD CARD11 BCL10 CTLA4 CHUK FOS NFKBIA IL12B IL23R MYD88 MTOR IFNB1 STAT4 IL12RB1 HLA-DRB1 GSK3B CD3G CD3E IRF2BPL NFATC1 PTPRC IL23A CCL28 PIK3R1 IL18R1 CDKN1A FOXO3A LTA MAPK1 PLCG1 LCP2 MAPK3 CDKN2A LAT MAP2K1 RPTOR MAP2K2 TYK2 MLST8 GRB2 SOS1 IL17A BCL2L1 TSC1 ICOS JUN IL2 PPP3CC TSC2 IL4 HRAS IFNG RAF1 IL12A CCND1 BAX IFNAR2 CCL19 ZAP70 RICTOR RHEB TNF IFNAR1 PRKCQ IKBKG DEPTOR PTEN PDPK1 FYN LCK NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260910%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NLGN1 GRIN2B GRIN1 GRIA2 DLG4 NLGN3 GRIN3B GRIN3A GRIA3 NLGN2 GRIA4 NRXN1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260910%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3R3 PIK3R5 PIK3R2 PIK3R1 PIK3CD PIK3C2G PIK3C2B TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260910%WP1471%HOMO SAPIENS Target of rapamycin signaling TSC1 AKT1S1 MAPKAP1 CDC42 TSC2 FKBP1A HMGCR DDIT4 IDI1 MTOR RICTOR RHEB EIF4EBP1 PRKCA PRKAB2 PRKAA2 PRR5 DDIT4L RRAGA PRKAG1 RAC1 RRAGB PRKAG2 RRAGD PRKAB1 PRKAG3 RPTOR ULK2 ULK1 MLST8 PRKAA1 RPS6KB1 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260910%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM MDC1 FANCD2 TP53BP1 ATF2 NABP2 TRAF6 MRE11A RAD52 RIF1 RAD50 SMC3 RAD51 CDK5 HSF1 MDM2 BAX RAD17 ATM BLM RAD9A ATR RNF8 H2AX YAP1 PRKDC CASP9 KAT5 MCPH1 PCNA CDKN2A CHEK2 BRCA2 CASP3 LATS1 TP73 CHEK1 TRIM28 NBN APAF1 RASSF1 ACTL6A TERF2 SMC1A BAK1 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260910%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection RRAS ITK CBL CD3D NFKB1 IKBKB GRAP2 CD40LG CARD11 BCL10 CTLA4 CHUK PAK1 PDCD1 FOS CSF2 NFKBIA DAG1 PTPN6 MAP3K8 MAP3K14 MAPK9 GSK3B PTPRC NCK1 PLCG1 MAP3K7 CHP1 LCP2 AHSA1 MAPK3 LAT IL5 MAP2K1 MAP2K2 GRB2 SOS1 IL10 CALM1 NFATC2 ICOS JUN IL2 IL4 IFNG RAF1 CDK4 ZAP70 TNF PRKCQ IKBKG CD8A FYN LCK APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260910%WP1772%HOMO SAPIENS Apoptosis modulation and signaling TRADD RIPK1 FADD CRADD TNFRSF1A NAIP NFKB1 IKBKB BIRC5 TRAF6 AIFM1 FOS NFKBIA IL1R2 IRAK1 MAP3K14 MYD88 HTRA2 DIABLO TNFSF10 MCL1 BCL2L11 BBC3 TNFRSF1B CASP9 DFFB BIK PIDD1 CASP6 DFFA MAPK3 CDKN2A HRK CASP2 TNFRSF6B TNFSF6 CASP4 CASP3 BOK PTRH2 MADD TNFRSF25 BLK BAD BCL2L10 APAF1 BAG3 TRAF3 BMF BNIP3 TNFRSF10C TNFRSF10A SEPTIN4 TNFRSF10D BCL2L2 BCL2L1 PMAIP1 BCL2A1 JUN TNFRSF10B IL1R1 BCL2 CASP10 BAX CYCS BIRC7 PTPN13 BIRC2 BIRC3 PRKD1 MAP3K5 SMIM40 AIFM2 MAPK8 CASP8 BAK1 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260910%WP4255%HOMO SAPIENS Non small cell lung cancer RET JAK3 PIK3CD STK4 STAT5B RXRB RXRG CRABP2 BRAF HGF CRABP1 AKT3 RARB RB1 TGFA CDKN1A FOXO3A MAPK1 PLCG1 CASP9 MAPK3 CDKN2A CASP3 MAP2K1 MAP2K2 BAD STAT3 RASSF1 DDB2 GRB2 SOS1 FHIT GADD45B GADD45A EML4 NRAS GADD45G HRAS RAF1 CDK6 CDK4 CCND1 RXRA EGF BAX CYCS ERBB2 PRKCB PRKCA ARAF KIF5A HEL-S-61 PLCG2 POLK ALK SOS2 EGFR PDPK1 E2F2 E2F3 CASP8 BAK1 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260910%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb POLR3E MTOR MAPK14 MAPK12 MAPK13 MAPK11 MAPK1 MAPK3 MAP2K1 RPTOR MAP2K2 NDUFS8 MLST8 NDUFS3 COXFA4 RPS6KB1 RAB5IF MOSMO TRPM7 CALM1 PDZD9 RPS6KA1 SDR42E2 VWA3A UQCRB CDC2 UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 CDK2 UQCRFS1 COX7C CYC1 NDUFA9 UQCRC2 COX5A CDR2 PRKAB2 PRKAA2 EEF2K PRKAG1 PRKAG2 PRKAB1 PRKAG3 EEF2 PRKAA1 CDH18 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260910%WP186%HOMO SAPIENS Homologous recombination RAD52 POLD2 RAD50 RAD51 BRCA2 NBN RAD54B POLD3 POLD4 MRE11A RPA1 ATM PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling BCL2L2 TNFRSF1A CXCL8 RELA NFKB1 BCL2A1 IKBKB VCAM1 BIRC5 SELE NFKB2 CD40LG TRAF6 PTGS2 IL2 CHUK IL1A CSF2 CCND1 MMP2 BIRC2 BIRC3 MMP9 TNF CXCL2 REL EGLN2 MMP3 RELB IL1B IL6 VEGFA SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260910%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response TRADD RIPK1 FADD TGFB1 NFKB1 EP300 TRAF6 TRAF2 PF4 CCL2 CSF2 TANK ACE2 IFNB1 TRAF5 LARP1 CCL4 CCL3 TFAP2A IL6R JAK1 HDAC2 STAT1 CXCL9 IL8RB CXCL12 TRAF3 NUP98 IL6 IRF7 IFITM1 IL10 CXCL8 CXCL17 CXCL13 IFIT2 AP1G1 HAVCR2 LAG3 hEMMPRIN CD160 TP53I3 RAE1 PPBP CXCL6 CXCL3 CXCL5 TLR7 TBK1 DHX58 TRIM25 IFNAR2 STAT2 MX1 CXCL11 IRF3 CXCL1 TNF IFNAR1 CXCL2 MAVS RIGI CCL5 CASP8 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis UGT2B7 CYP11B2 AKR1C1 AKR1C2 UGT1A10 AKR1D1 AKR1C4 SRD5A2 HSD11B1 CYP21A2 HSD11B2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260910%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CCNE1 ATF2 BCL2L1 TSC1 CXCL8 NFKB1 IKBKB MAP2K3 PTGS2 RPS6KA5 GSX1 FOS IL1A BCL2 NQO1 IPCEF1 PIP SIRT1 NRF1 NOS2 KEAP1 CDK2 MDM2 MTOR ATR MAPK14 RHEB TNF FOXO1 CDKN1A IKBKG HMOX1 MAP3K5 PTEN MAP2K4 PINK1 CHEK1 NFE2L2 MAPK8 IL6 CREB1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260910%WP5598%HOMO SAPIENS Sodium channel in epilepsy CAMK2A SCN8A CALM1 SCN5A WEE1 BACE1 FGF14 PTPRN SCN11A PDCD10 SCN7A SCN3B SCN3A SCN1B MAPK8IP2 SCN1A SCNM1 FGF13 SCN4A FGF12 SCN4B SCN2B RNF121 PRRT2 GSK3B SCN2A TNF SCN9A PSEN1 SCN10A FYN NEDD4 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation FGF18 SNAI1 FGFR3 RAF1 IHH FGF9 NPR2 CNP PTH1R MAPK14 MAPK12 MAPK13 MAPK11 CDKN1A SOX9 MAPK1 RBL1 THRA MAPK3 PPP2CA MAP2K1 MAP2K2 STAT1 BMP4 BMP2 PTHLH DKFZp686F0183 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260910%WP5506%HOMO SAPIENS Disorders of NAD metabolism NAXE NAXD NADSYN1 BST1 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260910%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials PORCN CREBBP LRP5 LRP6 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260910%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 IL6ST CHI3L1 STAT3 BAX SOCS3 MYC ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP3996%HOMO SAPIENS Ethanol effects on histone modifications ATF2 ADH1C HEL-S-117 ADH1A ALDH2 HEL-S-53e TYMS DHFR HDAC10 ALDH1A3 ELP3 HDAC1 CYP2E1 ACSS2 ALDH1A2 HDAC5 HDAC8 HDAC7 MTR HDAC2 HDAC3 SLC19A1 HAT1 KAT2B MAT1A NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EIF3A EXOC4 EXOC3 EXOC5 ROCK2 RTN4R EXOC1 USP1 EED IFNB1 EXOC8 EXOC2 EZH1 ARHA NGF MCL1 MAPK1 CCNA2 CRY1 MAPK3 CCNE2 ARF6 SOS1 CCNE1 MAP3K2 CENTA2 PER1 MAP3K1 HEL-S-15 EXOC7 SYN1 BCL2 JARID2 TUBB RAF1 RAD51 EXOC6 EGF NGFR RAD9A ATR HOXA1 HOXA9 POLRMT MAVS EVL LIMK1 SDC2 INPP5A RBBP7 RIGI H3C8 E2F6 WDR48 RAB11FIP4 TEFM SUZ12 UTP6 H4C9 PCNA ATAD5 OMG HIST1H4L COPRS EVI2A CRLF3 EVI2B RFC3 SUPT5H RAB11A METAP2 RFC4 MYT1 H3C15 RFC2 EGFR NF1 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260910%WP1422%HOMO SAPIENS Sphingolipid pathway SPTLC1 SGMS2 CERS3 CERS5 CERS6 KDSR CERK CERS2 SGMS1 PPP2CA ASAH2 SGPP2 SPHK2 ACER1 SPHK1 SGPL1 GBA2 SPTLC2 UGT8 SPTLC3 UGCG SERINC1 CERT1 PLPP1 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260910%WP3972%HOMO SAPIENS PDGFR beta pathway GRB2 EIF2AK2 SOS1 SHC1 PRKCB PRKCA PIK3R1 JUN MAP3K1 PLCG1 STAT5B FOS HRAS MAPK3 JAK1 RAF1 MAP2K4 MAP2K1 STAT1 STAT3 MAPK8 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260910%WP4463%HOMO SAPIENS Steroidogenic pathway STAR CYP11A1 CYP17A1 HSD17B1 HSD3B1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5406%HOMO SAPIENS 13q12 12 copy number variation ATXN1 SNTA1 TNFRSF19 C1QTNF9B SPATA13 TRAF1 MIPEP TRAF2 RTN4R CDC42 SGCD SGCA SGCB SACS DAG1 DMD SGCG MAPK9 ARHA SSPN SNTB1 TRAF5 RAC1 LINGO1 TRAF3 RTN4 MAPK8 C1QTNF9 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGA6 CD63 IGSF8 CD82 SPPL2C PRDM11 ACCS PHF21A C11orf96 CD19 GLI3 ALX4 LGALS3BP TP53I11 LARGE2 PEX16 IZUMO1 SLC35C1 VANGL1 SYT13 MAPK8IP1 FREY1 REST SLC25A17 B4GAT1 HLA-DMB B3GNT7 PEX3 TSPAN18 HLA-DMA MS4A1 TIMP1 ITGB1 B4GALT4 SDCBP SHH ALKBH3 CHST6 CRY2 CD151 LEF1 ITGA4 CHST1 HBEGF EXT1 NRXN1 EXT2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260910%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons CHRNA5 CHRNA6 PPP1R1B KCNK3 DDC CHRNB2 DRD2 DRD3 DRD4 GNAI1 SLC18A2 GNG2 CDK5 TH GNB1 CHRNA3 KCNK9 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP69%HOMO SAPIENS T cell receptor signaling ITK ATF2 CBL CD3D CRK RELA NFKB1 IKBKB GRAP2 TRAF6 CARD11 BCL10 CDC42 CHUK PAK1 GAB2 FOS NFKBIA MAP3K8 MAP3K14 MAPK9 CD3G PSTPIP1 MAPK14 SHC1 FYB1 CD3E WAS NFATC1 REL PIK3R2 PIK3R1 MAPK1 NCK1 PLCG1 MAP3K7 LCP2 MAPK3 LAT MAP4K1 MAP2K1 MAP2K2 PTPN11 VAV1 CREB1 GRB2 HEL-S-81p SOS1 SH2B3 NFATC2 ICOS JUN HRAS RAF1 ZAP70 PTK2B PRKCQ IKBKG CRKL VAV3 RIPK2 PDPK1 MAPK8 CD8A FYN LCK CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260910%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction TSLP BMPR1A BMPR2 IL11 IL15 IFNB1 IL3 IL7 IL17RA AMH INHBB IL20RA IL19 IL20RB TNFRSF11B GDF5 TNFRSF10B IL1R1 PRL ANP32B IL15RA PRLR CSF2RA BMP5 CCL5 BMP3 TGFB1 IL2RG TGFBR2 TNFRSF21 CD40LG PF4 IL2RA IL2RB CCL2 INHBA CSF3 ACVR1B CSF2 IL1R2 CCR3 CCR2 IL13 MSTN TNFRSF12A TNFSF12 IL11RA ACVR2A CCL28 IL18R1 LTA CCL4 CCL3 BMP7 IL5 ACVRL1 TNFRSF25 CXCR4 CXCL9 CXCL12 CSF1 ACVR1 TNFRSF10C TNFRSF10A IL17F IL17A INHA GDF3 CXCL17 PPBP TPO NGFR ACVR2B IFNK BMP10 CCR8 CCR6 IL17D IL17C IL1RN CX3CR1 IL17B CSF3R CCL1 TNFRSF19 IL33 CCL20 IL10RB CSF1R EPO IL7R GHR TNFSF10 GDF15 CNTFR CXCL16 IL27RA IL36A NGF IL36B IL3RA gdf7 TNFSF14 IL13RA1 IL36G GDF1 GDF6 TNFRSF1B IL1F10 IL22RA1 TGFBR1 CD27 IL20 TNFRSF13B TNLG2B IL26 IL27 TNFRSF13C PF4V1 IL17RB CCL14 IL8RB CCL13 CXCR6 CCL18 CCL15 RELT GDF10 CCL27 CCL25 CCL26 EPOR GDF11 CCL24 IL31 CCR10 IL37 IL34 CCR1 IL10RA BMP8B GHB2 XCR1 CLCF1 TNLG8A BMP6 AMHR2 CCL4L2 MPL TNFRSF8 IL13RA2 EDAR TNFRSF17 IL36RN TNFRSF14 CXCL6 INHBC CXCL3 INHBE CXCL5 BMP15 TNFRSF18 CD40 XCL2 IL25 XCL1 IL9R CCL8 IL1RL2 CCR7 ACVR1C TNLG7C CCL7 CCR5 LTBR CCR4 TNFSF11 CNTF CXCL1 TNF CXCL2 LEPR IL5RA CSF2RB CXCR1 LIF BMP4 IL1RL1 TNFRSF11A TNFRSF1A IL22 IL23R IL-21 NODAL IL18RAP IL21R IL12RB1 IFNGR1 IL23A IL6R TNFSF6 ACKR4 LTB ACKR3 IL24 TNLG7A CXCL14 IL6 IFNL2 IFNL1 IFNL3 IFNLR1 IL6ST IL17RC IFNW1 IL10 CXCL8 CCL11 IFNA2 IL18 CXCL13 TNLG1B TNFRSF4 LEP IL2 CCL22 CCL23 TNLG5A IL4 IL1A TNFRSF9 IFNG CX3CL1 CXCR5 CCL19 IFNAR2 IFNGR2 CCL21 GH1 CXCL11 IL9 IFNAR1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260910%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure STAR HEL-S-2a CASP3 MAPK10 HSD3B2 CYP11A1 PARP2 BAX TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation BCL2L1 SPI1 NFKB1 MEF2C TLR8 TLR7 CD40 TLR4 TLR1 ID3 TLR3 TLR9 MYC SPIB POU2AF1 TLR10 IL21R CD79B TLR5 CD79A BCR CDKN1A CDKN1B LYN IRF4 SYK CDKN2A IRF8 CCND3 CCND2 POU2F2 BCL6 TCF4 TNFRSF13C TCF3 EZH2 MEF2B STAT3 IL6 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260910%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE CHKA PEMT PDHA1 ChAT PDHA2 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260910%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK1 INS GCG GLP1R PCSK2 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260910%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling RAPGEF1 CRK PPM1G ROCK1 ROCK2 SRC PXN ACTG1 CDC42 GJA1 PAK1 RAP1A CSK CACNA2D1 DLL4 MAPK9 SHB MAPK14 MAPK12 BMX EPRS1 HBEGF CREB1 PNP VPS39 TPM3 PLAUR F3 NCL DECR1 EZR HEL-S-87p TBCA MMRN2 MOV10 MDM2 IGFBP7 CYCS LMAN1 CCT7 ARF4 RPS6 ADAM10 ITCH SH3BGRL3 ACACA FOXO1 TAOK2 PTK2B PTPN1 PTMA ERG HGS FGA EIF3S3 ELOA FYN HEL-S-78p EIF3F EIF3D NFKB1 ALB SELE ENG RPS6KA5 CCL2 GATA2 RPS11 ATP6V1E1 CTGF SPIRE1 EPHB2 MMP2 TRPC3 GLUD1 TRPC1 HEL-S-2a ARHA P4HA2 SDF2L1 FHL2 PLCG1 AFDN PSMD4 HYOU1 TEAD4 PABPC1 AAG1 TNFRSF25 MMP10 ATF4 ELOC HEL-S-99n MMP14 MLST8 TNFRSF10C VEGFA FRS2 HEL107 NOX4 TUBA1C PPP3CA PTGS2 AKT1S1 hEMMPRIN HEL-S-15 CSRP2 HRAS PLCB3 EPHA2 NCF1 GRB10 DOK1 PRKAA2 TUBB8 MAP3K5 CYBB ACOT9 ERN1 BMP10 PPP2CA NAPA XB CLTC FOXO4 PRKAA1 AP2A1 HEL-S-133P CYR61 HEL-S-68p HEL-S-162eP NR4A3 ATF2 CBL RELA AP2S1 BIRC5 NUMB NFKBIA PTPN6 TXNIP KDR SLC8A1 NCF2 MAPKAPK5 SDCBP HBD ADRB2 LDB2 HLX HEL-S-128m KL NFATC2 ADAM9 EIF4E SET MAP2K6 SLC2A14 MAP2K3 JUN DKK1 TXN BCL2 RAF1 CCND1 RPL5 TRAF3IP2 RICTOR CNP RPL7 RPL18A LUC7L UBAP2L CHAC1 SHC2 IER5 FBXW11 TMEM170A SND1 INPP4B KATNAL2 EWSR1 SIAH2 BIN1 ACACB RPL27 PRKD2 RPL26 PFN1 ATP6V0D1 FLII SH2D2A GIGYF2 FXR2 DUSP5 DHX36 MICAL2 BMP2 PRRC2C LARP7 CALU DHX29 FARSB MAPK8 NRP2 FAF1 CCRL2 KCNC3 CCDC124 EIF4G1 FADD EEA1 TMSB4X RPLP2 CLIC1 CGNL1 SSR4 EGR1 SSR3 FJX1 GPX1 KANK1 CRIP2 SLC7A1 APOLD1 FGD5 DNAJB9 GPC1 BRD4 MEF2C COPG1 HEL2 EIF2A FHOD1 CTNND1 PLOD3 RPL10A tal-1 DPM1 TMSB10 TMOD1 TMOD3 MYL2 SEMA6D ARMCX1 RAB37 ZNF555 RAB5A DSC1 MTOR TFAM LRRC59 PSMD11 HTRA1 QK3 ZC3H15 GSK3B SHC1 HEL-S-94n NFATC1 HEL-S-84 HDAC1 RCAN1 PIK3R2 TFCP2 PIK3R1 SYNJ1 TPP1 FOXO3A GRSF1 C15orf39 MAPK1 RAC1 RPL13a NCK1 NRARP RND1 CAPZB LRRFIP2 MAPK3 ADAMTS9 PRKG1 MAP2K4 ARHGEF15 MAP2K1 SHROOM2 MYH9 MYO6 CREBBP ANXA1 HEL164 MAP2K2 EPN1 STAT1 MAPKAPK2 FUT1 FLT1 SARS1 SLC25A11 ACKR3 STAT3 DNAJB4 FAM120A PTPN11 WASF1 ABCF2 SLC25A25 PDE4DIP CDC42BPB RPS6KB1 GRB2 ARF6 FMNL3 PLA2G5 PTPN9 FLNB BCL2L1 MYO1C CXCL8 HMGB1 MAPKAP1 DKFZp686L0365 CAMKK2 CTNNA1 S1PR1 IQGAP1 PRKCI ITGB1 PRKCB PRKCE PRKCA ITGB3 LIMK1 SRPK1 HEL114 PRKD1 HDAC5 HDAC7 NOTCH4 HEL-S-102 RAB4A PRKCZ SRP54 RAB11A ITGAV AMOT OCRL PDPK1 VAV2 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260910%WP5158%HOMO SAPIENS Urotensin II mediated signaling CAMK2A TGFB1 RELA NFKB1 IKBKB VCAM1 EP300 CHUK MAPK9 MMP2 NCF2 AGTR1 MMP9 GSK3B SMAD2 MAPK14 ARHA ACTA2 MAPK1 HMOX1 CASP9 ESPL1 MAPK3 CASP3 CREBBP NPPB STAT3 PTPN11 IL6 TRPC4 CCNE1 PLN HSPA2 NOX4 CDC2 DDIT3 ALOX5 BCL2 COL2A1 CDK2 NCF1 BAX NCF4 CYBA IRF3 COL1A1 TNF UTS2R HDAC5 GSK3A CYBB PCNA NPPA PTEN UTS2 ABCA1 IL1B EGFR COL3A1 AIFM2 MAPK8 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260910%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome HNRNPH1 CAMK2A CEBPD MEF2C SMC3 IGF2 REST CDON APOC2 GRIA3 GRIA4 MTOR GAD1 SIN3A HDAC1 NCOR1 SST TAF1 TET2 BCL6 EZH2 POU3F2 CREB1 DLX5 PSIP1 RBFOX1 GPRIN1 TET3 DLX6 NREP TARDBP FUT8 PRPF38A POU4F1 HNRNPF SP3 BDNF TET1 SGK1 FOXG1 UBE3A FGF3 IGF1R FGF4 OPRK1 FKBP5 CTCF RPS6 FUS CNP GRIN1 FGF2 HEL-S-20 MBP SP1 PTEN IGF1 YBX1 MYT1 NF1 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260910%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 USP1 CDKN1A ID1 ARCN1 GIG8 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260910%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia CSNK1A1 GSK3B NR1C2 APC RARA AXIN2 FLT3 RUNX1T1 DKK1 PML JUP PYGO1 ZBTB16 BCL9 WNT1 TCF3 LRP5 CCND1 LEF1 MYC WIF1 LRP6 SALL4 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCL IDI2 MVD HMGCR ACAT2 FDFT1 FDPS HMGCS1 GGPS1 IDI1 ACAT1 MVK ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260910%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis FAAH HTR1A CACNA1H KCNQ2 TRPA1 KCNQ3 TRPV1 PTGS2 PTGS1 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260910%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis CPLX1 RPH3A RIMS1 UNC13A SYT1 STXBP5 STXBP6 SYP NAPA GDI1 SNAP25 STX1B STXBP1 CACNA1B VAMP2 CACNA1A OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260910%WP322%HOMO SAPIENS Osteoblast signaling IBSP PTH1R COL1A1 PDGFRA PTH ITGAV SLC17A2 ITGB3 TNFRSF11B FGF23 TNFSF11 BGLAP TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260910%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals CEBPB SLC7A11 PRKCA AIMP2 HMOX1 NQO1 GCLC MAF GCLM KEAP1 NFE2L2 EPHB2 MAPK8 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260910%WP5028%HOMO SAPIENS Glycine metabolism including IMDs SHMT1 HEL-S-302 AMT DLD LIPT2 LIPT1 GLDC HSCB LIAS NFU1 GCSH BOLA3 ISCU WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260910%WP399%HOMO SAPIENS Wnt signaling and pluripotency TCF7L2 FZD9 TCF7L1 FZD8 APC PTPA WNT2B EP300 CTBP2 WNT9B CTNND1 WNT16 FZD1 PAFAH1B1 FZD3 POU5F1 LRP5 WNT3A WNT7A NKD1 NKD2 WNT3 LRP6 MAPK9 WNT7B GSK3B AXIN2 ZBTB33 MAPK10 ARHA PPP2R5E NLK LRRK2 PPP2R5C NFYA MAP3K7 CCND3 CCND2 MAP2K4 MMP7 CREBBP PPP2R3A SOX2 PPP2R2C NR1C2 PPP2R2B hCG_2014051 JUN CD44 PPP2R1B PPP2R1A FOSL1 FZD10 CCND1 MYC FRAT1 PPP2R2A PPM1J PRKCI PPP2R3B PRKCH WNT5B PRKCB PRKCE PRKCA DVL1 DVL2 PRKCQ PRKD1 DVL3 CTBP1 FOXD3 PRKCZ PPP2CA WNT1 WNT4 AXIN1 LDLR WNT10B ESRRB LEF1 WNT10A FZD2 FZD5 FZD4 FZD7 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation MYO15A ATG101 DRG2 PPP1R14A RELA ROCK1 RB1CC1 PARK2 IFT70B WDR26 PCK1 RANBP9 RMND5A MKLN1 GID4 CLUAP1 MED9 NR1H2 TNFRSF13B CLEC16A WWTR1 CREB1 RAB10 JUN CDC2 BAX MYC BIRC2 BLM FOXA1 ARG2 TNF CLTB GRIP1 FOXA2 IRF8 PARD3 FLII PTEN IFT172 PARD6B IFT74 IL1B RNF41 RAI1 COPS6 NFKB1 SHMT1 PEMT GPR85 FHOD1 MAP3K14 MYD88 MTOR ARHA APP RRAGA YAP1 BCL2L11 CRY2 CRY1 TNFSF13 G6PC1 ETV5 BCL6 RPTOR STAT3 ULK1 MLST8 NR1H3 CARM1 PER1 TRAF3IP1 MAEA TLR4 ARMC8 C9orf72 COPS7A IFT80 HES6 PRKCI FERD3L ALKBH5 CFL2 DENR IFT22 MIGA1 TOM1L2 IFT81 LLGL1 LIMK1 DRC5 IFT27 DRC7 DRC8 PLD6 RAB8A IFT46 RAB39B COPS4 DRC1 IFT25 PRKAG2 IFT20 GDI2 PRKAB1 WDR41 COPS5 FLCN ATPAF2 RMI2 RMI1 COPS8 TOP3A TTC26 ITPK1 TFEB DRC10 MYH2 SMCR8 CLTC GPS1 IFT52 MIEF2 CLTA RASD1 IFT57 PRKAA1 FNIP1 FNIP2 HEL-S-133P MYO16 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260910%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR MDC1 DCLRE1A MSH2 TP53BP1 UBE2D3 UIMC1 SHFM1 TOPBP1 XPA HUS1 EEF1E1 ABRAXAS1 BRCC3 PPM1D RECQL4 BRIP1 RBBP8 WRN CLSPN RFWD3 USP1 FANCA CEP164 RPA1 RECQL PALB2 PLK1 SMARCAL1 H2AX POLN HERC2 MCPH1 CHEK2 BCL6 CHEK1 TRIM28 SMARCC2 FOXM1 NBN SMC1A FANCD2 ATRIP CDC45 MRE11A PML CDC2 RAD52 RAD50 TDP1 RAD51 CDK2 MDM2 RAD17 RAD1 ATM RAD9A BARD1 ATR RNF8 CLK2 IKBKG FEN1 PRKDC SP1 PCNA XRCC5 RMI1 BRCA2 TOP3A MCM2 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260910%WP3930%HOMO SAPIENS EDA signaling in hair follicle development BMP1 SOSTDC1 DKK4 SHH RELB LTB TNLG7C WNT3 DKK1 EDAR EDARADD PTCH1 SLEEP REGULATION%WIKIPATHWAYS_20260910%WP3591%HOMO SAPIENS Sleep regulation DRD1 DRD2 PTGDR HCRTR2 DRD3 HCRTR1 IL18 PER3 GHRH GHRL CACNA1I FOS MRGPRX2 BTBD9 SLC29A1 ADORA2A TH STAR NPY2R ADA HEL-S-2 CHRNB2 UTS2R DLAT OXT OXTR CRH NLGN1 MTNR1B UTS2 NPS HTR2A IL6 NPAS2 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260910%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AB1 BCOR MACROH2A2 H2AX H3C8 MAPK1 SUZ12 H2AJ MAPK3 H2AB3 BCL6 RNF2 PCGF1 H3C15 EZH2 H2AZ1 H2AZ2 H3F3B EED VISUAL CYCLE%WIKIPATHWAYS_20260910%WP5534%HOMO SAPIENS Visual cycle RBP1 OPN1MW RPE65 RDH5 RDH12 LRAT RHO ABCA4 OPN1SW RBP3 OPN1LW RDH11 RDH8 RLBP1 RDH10 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260910%WP334%HOMO SAPIENS GPCRs class B secretin like CRHR2 ADGRE5 PTH1R CALCR ADGRL1 ADGRL4 GHRHR ADGRL2 ADGRL3 ADCYAP1R1 CALCRL VIPR2 GIPR GCGR GLP1R SCTR GPR64 DOPAMINE METABOLISM%WIKIPATHWAYS_20260910%WP2436%HOMO SAPIENS Dopamine metabolism NQO1 PPP2CA DDC TYR TH PRKACG MAOA HEL-S-44 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation DKFZp781O1323 SMAD9 WNT4 DCN FOXO1 SMAD1 BMP2 SFRP1 SST BCL2L11 DKK1 LEFTY2 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260910%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells TGFB1 TNFRSF1A TRPV5 RAF1 BRAF BAX TNFSF11 MTOR CALCA FFAR3 SMAD2 PDE1B SEC16B HEL-S-41 ACTA2 MAPK1 MAP3K5 CASP9 TGFBR1 PTH CASP3 SMAD4 APAF1 PPP3R1 CASP8 BAK1 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260910%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260910%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA HSD17B4 ACOX1 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome MDC1 RNF168 NIPBL RNF8 CBX3 H2AX ATM ATR ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260910%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development CSNK2A2 PRRT2 KCNQ2 CSNK2B SCN2A SPTBN4 BRSK1 ANK2 L1CAM SPTAN1 DDIT3 SCN5A EIF2A SEMA3A SNAP25 ATF4 CSNK2A1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260910%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOP DIO1 CTH RELA NFKB1 GPX2 GPX1 JUN GPX4 GPX3 SP3 FOS FABP1 SEPHS2 SELENOO SELENON SELENOM SELENOW SELENOV SELENOT SELENOF SELENOK SELENOI SELENOH MSRB1 SELS RPL30 TXNRD2 HEL-S-134P SP1 SEPHS1 GPX6 PSTK EEFSEC POU2F1 TRNAU1AP SEPSECS SARS2 NFE2L2 SARS1 CREM LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism EPHX2 ALOX15 ALOX5 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma GRB2 SOS1 TGFB1 BCL2L1 COL4A2 CXCL8 NFKB1 BIRC5 PTGS2 JUN CD44 NOS2 CCND1 MYC BIRC3 RRM2 MAPK14 HNF1A HIF1A CDKN1A RAC1 CASP9 CXCR1 IL6R TGFBR1 MAPK3 JAK1 TNFSF6 CASP3 FRZB MYOF LEF1 STAT3 HEL-117 SMAD4 PTPN11 E2F2 MAPK8 IL6 VEGFA VAV2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CNNM3 CNNM4 CIAO2A FER1L5 STARD7 SEMA4C ARID5A ASTL ZP2 NEURL3 KANSL3 PLXNB2 MMS19 COL2A1 ERBB2 ADRA2B SNRNP200 ARHA ANKRD23 MAPK1 MAPK3 DUSP2 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 COX11 CIAO2B MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260910%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKBIA RRAS RAF1 NFKB1 IKBKB MAP2K6 TRAF6 IKBKG MAPK1 MAP3K14 MAP3K1 CHUK CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260910%WP2029%HOMO SAPIENS Cell differentiation index LEFTY1 TLX3 TLX2 STAT3 HDAC5 TLX1 LEFTY2 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260910%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TGFB1 ITGB1 ITGA6 TNF ZEB2 SFRP1 TERT ALPL CLDN4 CCND1 NRG3 MYC ERBB4 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260910%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260910%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer DNAJB1 CRTC2 SIK1 GNAS HDAC5 SIK3 SIK2 CREB1 HDAC7 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260910%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction HEL-S-80p PPP1R14A CALM1 ARHA ROCK1 ROCK2 MYLK MYL1 GDI1 ADRB2 PLCB1 RYR1 IL13 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260910%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin IL2RG VCAM1 JAK3 IL2RB CCL2 STAT5B GATA2 SELL IL15 IL3 MAPK11 MCL1 CCL4 CCL3 MAPK3 JAK1 MAP2K4 CXCR4 CXCL12 PIBF1 IL6 VEGFA IL10 CXCL8 MRC1 MADCAM1 IL4 GAB3 BCL2 NCR1 IFNG NCR2 NCR3 CX3CL1 CD69 HLA-G CCL8 CCL7 ANGPT2 PGR ANGPT1 IL15RA KIR2DL4 CXCL11 NR3A2 TNF CXCR3 NR3C1 ITGA4 CCL5 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260910%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 SMARCE1 ACTL6B ARID1A GLI3 CDK6 GLI4 CDK4 DPF1 DPF2 DPF3 EED RB1 SMO SMARCA4 SUZ12 CDKN2A SMARCD1 RBBP4 SMARCC1 EZH2 SMARCD2 SMARCC2 SMARCD3 H3F3B ACTL6A ARID1B PTCH1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260910%WP2253%HOMO SAPIENS Pilocytic astrocytoma GRB2 HRAS SOS1 RAF1 BRAF PTPN11 NRAS NF1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260910%WP696%HOMO SAPIENS Benzo a pyrene metabolism AKR1C1 CYP3A4 HEL-S-165mP AKR1C2 CYP1A1 AKR1C4 EPHX1 CYP1B1 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260910%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ENO1 HEL-S-68p HEL-S-162eP HEL-S-87p GPT HEL-S-49 PFKM PGAM2 HEL-S-30 HEL-S-133P SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260910%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction NDUFAF1 NLRX1 SIRT6 TNF NFKB1 MAVS RPS6KA1 TERF2IP IL18 TRAF6 ECSIT ACAD9 TERF2 TRAF3 TOMM70 REN MITA IL6 NLRP3 ACE2 NDUFAF2 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260910%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism HSD17B2 UGT2B7 CYP1A2 CYP3A4 HSD17B7 UGT2A2 CYP3A7 UGT1A8 SULT1E1 HSD17B10 CYP2C9 CYP2C19 UGT1A10 HSD17B4 HSD17B1 HSD17B3 HSD17B8 CYP1B1 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260910%WP5130%HOMO SAPIENS Th17 cell differentiation pathway TGFB1 CD3D NFKB1 IKBKB IL2RA GATA3 FOS NR1D1 NFKBIA IL22 IL23R RORC RORA IL-21 HLA-DMA MTOR TBX21 IL21R CD3G SMAD2 MAPK14 IFNGR1 RARA CD3E NFATC1 IL27RA FOXP3 IL23A SOCS3 MAPK1 PLCG1 CRY1 IL6R TGFBR1 LAT JAK1 IL27 STAT1 STAT3 TYK2 NFIL3 AHR IL6 IL17F IL17A PER1 PPP3CA JUN IL2 IL4 IFNG RXRA RUNX1 ZAP70 PRKCQ HIF1A IRF4 IL1B MAPK8 LCK GASTRIN SIGNALING%WIKIPATHWAYS_20260910%WP4659%HOMO SAPIENS Gastrin signaling MEF2D ATF2 CRK RELA IKBKB BIRC5 TJP1 ROCK1 SRC PXN CDC42 CHUK PAK1 FOS NFKBIA PPARG MAPK9 ELAVL1 MAPK14 CDKN1A CDKN1B KIT CASP3 YES1 CREB1 JUN KLF4 RAF1 MAP3K11 CCND1 MYC ARHGEF28 TFF2 BIRC2 BIRC3 RPS6 IRS1 ANXA2 CCKBR FOXO1 EIF4EBP1 LAMTOR3 SLC9A3 PRKD2 SP1 TCF4 BMP2 EGFR MAPK8 FYN NFKB1 EGR1 RHOD MEF2C MTOR GSK3B SHC1 ARHA PIK3R2 HDC PIK3R1 CLDN1 FOXO3A MAPK1 PLCG1 RAC1 KAT5 MAPK3 CDKN2A MMP7 MAP2K1 RHOB MEF2B BAD STAT3 PTPN11 VEGFA RPS6KB1 GRB2 SOS1 BCL2L1 CXCL8 SERPINB2 PTGS2 IL2 CD44 HRAS DKFZp686L0365 PRKCH ITGB1 GAST PRKCE PRKCA PRKCQ PRKD1 HDAC7 PIK3R3 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260910%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD1 GAD2 ABAT GPT PC GOT2 AGXT ASS1 ASL ASPA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260910%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis FADD MAPK14 MAPK12 BCL2L1 TNF MAPK13 MAPK11 MCL1 BCL2L11 BBC3 CASP9 BCL2 TNFSF6 CASP3 BAD BAX APAF1 CASP8 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP707%HOMO SAPIENS DNA damage response RB1 H2AX CDKN1A CDKN1B HUS1B BBC3 CASP9 TP53AIP1 PIDD1 CCND3 CCND2 CHEK2 CASP3 SESN1 CHEK1 TLK2 TLK1 NBN APAF1 RFC1 SMC1A DDB2 CREB1 CCNE2 RRM2B FANCD2 CCNE1 CCNB3 CCNB2 CCNB1 PMAIP1 SFN ATRIP GADD45B GADD45A MRE11A TNFRSF10B PML CDC2 GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 CCND1 MDM2 BAX MYC CYCS RAD17 RAD1 ATM RAD9A ATR PRKDC CASP8 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260910%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 ZAP70 MCL1 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260910%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260910%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 FLT3 STAT3 CCR5 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260910%WP5606%HOMO SAPIENS Beta globin gene expression regulation HBG1 MYB LMO2 HBE1 GATA1 ZFPM1 HDAC1 ZBTB7A HBB HDAC2 KDM1A CHD3 HBD KLF1 tal-1 NR2C2 MTA2 PPARGC1A GATAD2B HBG2 LDB1 AXON GUIDANCE%WIKIPATHWAYS_20260910%WP5289%HOMO SAPIENS Axon guidance RRAS ROCK1 BMPR2 SRC CDC42 RHOD EPHB1 EFNA1 FES FZD3 TRPC1 GSK3B ROBO1 gdf7 MAPK1 RAC1 NCK1 L1CAM CXCR4 CXCL12 SLIT1 SLIT3 BOC RGMA GNAI1 HEL-S-15 HRAS RAF1 CDK5 EPHA2 PARD6A ITGB1 SEMA5B PRKCA ROBO3 SHH DPYSL5 UNC5D SEMA7A ARHGEF12 NTN3 DCC MYL12B ROBO2 EFNB1 ABLIM3 PLXNA1 SLIT2 LRIG2 SRGAP2 RYK PRKCZ NTNG2 PARD3 NGL1 WNT4 SEMA3A PDPK1 NRP1 HEL-S-28 FYN PTCH1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260910%WP2889%HOMO SAPIENS Oxytocin signaling OXTR OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260910%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP1A2 CYP3A4 EPHX3 ALOX12B ALOX15 ALOXE3 CYP4A11 GPX4 PTGS2 CYP2C9 PTGS1 CYP2C19 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260910%WP136%HOMO SAPIENS Phase I biotransformations non P450 LIPA ESD CES1 HEL126 PON2 PON1 PON3 CES2 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260910%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport ABCC3 SLC51A SLC51B ABCC2 AKR1D1 CYP27A1 CYP7A1 SLCO1B1 ABCD3 ABCB11 SLC27A5 HSD3B7 ABCB1 BAAT AKR1C4 CYP7B1 FABP6 AMACR HSD17B4 ATP8B1 ABCB4 CYP8B1 SLC27A2 SLC10A2 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma FADD RPS6KB2 FGFR3 RELA NFKB1 TGFBR2 NFKB2 FGFR1 NUMB FKBP1A MAML1 AKT3 MTOR REL PIK3R2 RB1 SESN2 PIK3R1 TERT CDKN1A CDKN2A SESN1 IRF6 RPTOR NFE2L2 FAT1 TRAF3 MLST8 VEGFA TSC1 EIF4E MAPKAP1 TSC2 NRAS HRAS CDK6 CDK4 KEAP1 DDIT4 CCND1 IGF1R ERBB2 LTBR BIRC2 RPS6 RICTOR RHEB EIF4EBP1 PRKAA2 NOTCH2 AJUBA NOTCH1 PTEN PIK3R5 TP63 EGFR SMAD4 PDPK1 CSMD3 PRKAA1 CASP8 STK11 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260910%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways SNTA1 HEL-S-162eP EP300 RET GJA1 CAV3 REST ADCYAP1R1 GNB3 SLC25A4 VIPR2 VAMP2 DDC HSPD1 NGF NFYA RUNX3 HADHB AQP4 POU2F2 PBX1 CASP3 POU3F2 CREB1 SOX2 TPH2 NTRK2 JUN HEL-S-87p TH NKX3-1 C4B_2 YWHAG NR3A2 HEL-S-93 ASCL1 CHRNB2 TNF CPT1A MAOA HIF1A PPARGC1B NKX2-2 SLC9A3 SP1 ACADM CHRNA7 TF TCF3 PHOX2B IL1B PKNOX1 BHLHB2 HES1 CHRNB4 CREM TSPYL1 DLX2 HES5 DEAF1 SPTBN1 PHOX2A FEV CC2D1A EN1 NFKB1 NOS1AP KCNJ8 EGR1 NFKB2 GPD1L GATA3 GATA2 SCN5A HEL2 MEF2C HTR1A NEUROD1 POU5F1 RORA IL13 GCK CEBPB HDAC1 PAH YWHAQ ChAT HEL-S-1 SST IL6R AVP G6PC1 CREBBP TP73 LMX1B TACR1 TLX3 HTR2A FOXM1 TPH1 IL6 VEGFA IL10 CXCL8 C4A HEL-S-125m SP3 BDNF IL1A NR1A2 SCN3B PPARGC1A SCN4B CTCF MYB GRIN1 FREP1 MAP2 ECE1 PRKAR1B PRKAR1A NR3C1 YBX1 SNAP25 SSTR2 IL1RN RYR2 CHRM2 SLC1A3 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260910%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A IGF2BP1 XPO4 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260910%WP183%HOMO SAPIENS Proteasome degradation UBC UBE2D3 UBB PSMD10 RPN2 RPN1 PSMB10 PSMD5 PSMB9 HEL-S-283 HEL-S-91n IFNG PSME2 UBE2D2 HLA-B HLA-C HLA-A HLA-F HLA-G PSMA4 HLA-E PSMA2 PSMB6 PSMB2 PSMB3 PSMD11 PSMB8 UBE2D1 PSMC6 PSMC4 PSMC1 HEL-S-276 H2AX UBA7 HIST1H2AB UBE2B PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 PSMD12 PSMD13 H2AZ1 HEL-117 NEDD4 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260910%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation COA3 AS3MT UQCRFS1 ATP1A1 SDHA ND1 HEL-S-21 HEL-S-44 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260910%WP325%HOMO SAPIENS Triacylglyceride synthesis PNPLA2 GNPAT GPD1 DGAT2 DGAT1 AGPAT4 GPAM LIPE AGPAT5 MOGAT2 LPL MOGAT1 AGPAT3 LIPF MOGAT3 LIPC PLPP3 PLPP2 PLPP1 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260910%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A GRIN2B HCN1 ARHGEF7 SYNGAP1 DLGAP1 CDC42 HOMER1 PAK1 RAP1A HRAS PS1TP5BP1 CTNND2 SPAAR ARHGAP44 SHARPIN LZTS3 BAIAP2 GRIN1 ADGRL1 ITGB1 SHANK3 MAP3K7 SPTAN1 GRIA2 DLG4 SERINE METABOLISM%WIKIPATHWAYS_20260910%WP4688%HOMO SAPIENS Serine metabolism DHFR HEL-S-51e PSAT1 SHMT1 PHGDH TYMS PSPH MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260910%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 IRF7 NDUFAF1 TICAM1 NDUFB9 NFKB1 NFKB2 TMPRSS2 TRAF6 CGAS TLR7 ECSIT TLR3 IFIH1 TBK1 IKBKE MITA ACE2 AGTR1 IRF3 AGTR2 NLRX1 MAVS PHB2 CTSL RIGI ACAD9 TRAF3 TOMM70 REN FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260910%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH3A2 ACO2 CS ACSS2 ALDH2 ALDH9A1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP2571%HOMO SAPIENS Polycystic kidney disease pathway FZD9 FZD8 IKBKB WNT2B SRC GNAI3 FOS WNT9B WNT9A WNT16 FZD1 FZD3 WNT3A WNT8A WNT7A WNT8B BRAF WNT3 KDR MTOR CFTR PDE1A WNT7B GSK3B MAPK3 MAP2K2 FLT1 GNA11 TSC1 RPS6KA1 ADCY6 JUN GNAI1 TSC2 NRAS HRAS KCNN4 PKD1 GNAS FZD10 CCND1 EGF IGF1R MYC ERBB2 SFRP4 WNT5B RHEB TNF PRKAB2 DVL1 PRKAA2 DVL2 DVL3 PRKAG1 PRKAG2 PRKAB1 PRKAG3 PLCG2 WNT1 VEGFB IGF1 PRKACG WNT4 SLC12A2 WNT10B SSTR2 WNT10A FZD2 FZD5 PRKAA1 FZD4 FZD7 STK11 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK4 TNF CXCL8 NFKB1 TRAF6 MAPK1 IL1A IRAK1 TLR4 HEL110 IFNA1 IL1B TREM1 AGER MYD88 IL6 IFNB1 CD14 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma TGFB1 CADM2 COL21A1 CTSK TGFA DVL2 HIF1A SFPQ CDKN1A EP300 SETD2 EGLN1 EGLN3 EGLN2 CREBBP TFEB PRCC VHL ELOC RBX1 BIRC7 FH VEGFA HEME BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP561%HOMO SAPIENS Heme biosynthesis ALAS2 ALAS1 FECH UROD UROS HMBS CPOX MAPK CASCADE%WIKIPATHWAYS_20260910%WP422%HOMO SAPIENS MAPK cascade GRB2 SOS1 RRAS MAP3K2 MAP3K12 MAP2K6 MAP2K3 JUN MAP3K1 NRAS HRAS RAF1 PLCB3 BRAF MAPK14 MAPK12 MAPK10 MAP2 MBP ARAF RASA3 LAMTOR3 SIPA1 MAPK1 MAPK3 MAP2K4 MAP2K1 MAP2K2 SOS2 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260910%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX CYP4A22 NR1C2 CYP4F2 ALOX15 CYP4A11 ALOX12 PTGR1 LTC4S CYP4F12 ACOX1 EHHADH ACOX3 ALOX5 TRPA1 ALOX15B KPG_011 TRPV1 FPR2 LTB4R HEL-S-298 HPGD NR1C1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260910%WP35%HOMO SAPIENS G protein signaling RRAS GNAI3 GNAO1 GNB2 GNB1 GNB3 PDE1A PDE1B ARHA HEL159 AKAP12 AKAP10 AKAP11 PDE8A PDE1C AKAP7 GNG3 AKAP6 AKAP4 GNG5 GNA14 GNG4 GNA15 ADCY1 GNG7 KCNJ3 GNG8 GNAL PDE7B GNA11 PRKD3 GNAZ CALM1 ADCY3 ADCY6 PPP3CA GNAI1 ADCY5 PPP3CC NRAS HRAS PLCB3 ADCY8 ADCY9 GNAS GNG10 GNG12 GNG11 PRKCI GNG13 PRKCH PDE7A PRKCB PRKCE GNA13 GNGT1 PRKCA ARHGEF1 PDE4D GNB5 GNGT2 PRKCQ PRKD1 PDE4B PDE4A AKAP8 PRKCZ PRKAR1B PRKAR1A PRKACG AKAP5 AKAP9 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260910%WP585%HOMO SAPIENS Interferon type I signaling RAPGEF1 CBL CRK SOCS1 PIK3CD RPS6KA5 GAB2 RAP1A PTPN6 MTOR STAT4 MAPK14 PTPRC REL PIK3R2 PIK3R1 SOCS3 RAC1 RPS6KA4 JAK1 RPTOR STAT1 EIF4B STAT3 PTPN11 TYK2 MLST8 VAV1 CREB1 RPS6KB1 EIF4E MAP2K6 MAP2K3 MAP3K1 MAPKAP1 IFNAR2 STAT2 RPS6 ZAP70 IRS1 PIAS1 IRF9 IFNAR1 EIF4EBP1 EIF4A1 CRKL PRMT1 FYN LCK BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260910%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders RRM1 RRM2B DHODH RRM2 HEL-S-29 DPYD NT5C3A DPYS HEL74 UMPS TYMP TYMS COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260910%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway IL7 IL10 TNF CXCL8 TMPRSS2 IL2RA CCL3 IL2 CCL2 CSF3 IL1B IL6 ACE2 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling IGFBP2 HEL-S-68p BCL2L1 PMAIP1 BCL2A1 BIRC5 PTGS2 EPO NOS2 EDN1 BAX ANGPT2 ANGPT1 IGFBP1 TGFA HIF1A MCL1 PDHA1 SLC2A3 EGLN1 BNIP3 HEL-S-30 BAK1 HIF1AN PFKL BNIP3L HEL-S-133P VEGFA PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260910%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO4A1 SLCO1A2 SLCO1C1 SLCO3A1 SLC7A5 SLC16A2 SLC16A10 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260910%WP4842%HOMO SAPIENS Mammalian disorder of sexual development EMX2 RBFOX2 CBX2 FST FGFR2 MAPK11 AMHR2 SOX8 SOX9 PBX1 DMRT1 WNT4 DHH GATA4 FOXL2 NR5A1 WT1 SRY INSL3 AMH RSPO1 FGF9 MAPK SIGNALING%WIKIPATHWAYS_20260910%WP382%HOMO SAPIENS MAPK signaling FGF18 FGFR4 FGFR3 FGFR2 CRK FGF10 FGFR1 RASA2 CDC42 PAK1 RAP1A CACNA1I MAP2K5 CACNA2D1 CACNA2D3 CACNA2D2 BRAF CACNA2D4 PLA2G4F CACNB1 CACNB3 PLA2G4D MAPK9 CACNB4 PLA2G4E MAPK7 PLA2G4C CACNG6 CACNG7 CACNG8 MAPK14 CACNG1 MAPK12 CACNG2 MAPK13 CACNG3 MAPK10 CACNG4 MAPK11 CACNG5 LRRK2 CASP3 MAP3K12 NTF4 GADD45A IL1R1 ECSIT MAX RASGRP4 TAOK2 RASGRP3 LAMTOR3 RRAS2 CRKL RRAS TGFB1 NFKB1 TGFBR2 NFKB2 TRAF6 RPS6KA5 STK4 IL1R2 MAP3K8 MAP3K7IP1 MAP3K14 PDGFA HEL-S-31 MAP4K3 MAP4K1 MAP4K2 ATF4 PPP3R1 PPP3R2 MAPK8IP3 PPP5C DUSP8 DUSP9 DUSP7 PPP3CA RAPGEF2 TAOK3 MAPKAPK3 HSPA1A CACNA1G PPP3CC NRAS RASGRF2 DUSP16 HRAS PPM1B pk MAPK8IP2 FGF21 GNG12 IKBKG MAP3K5 PRKACG CACNA1C SMIM40 CACNA1B CACNA1F CACNA1A CACNA1S ATF2 RELA IKBKB FLNA TRAF2 CHUK FOS NTF3 FGF14 MAPK8IP1 FGF13 FGF12 MAPKAPK5 NGF TGFBR1 HEL-S-72p CD14 NTRK2 MAP2K6 MAP2K3 JUN MAP3K1 DDIT3 RAF1 MAP3K11 EGF MYC DUSP10 FGF2 TNF FGF20 FGF23 FGF22 FGF17 FGF16 FGF19 DUSP3 DUSP4 DUSP2 SOS2 IL1B EGFR MAPK8 NF1 PTPN5 TNFRSF1A JUND MEF2C CDC25B AKT3 NFATC1 NLK MAPK1 RAC1 MAP3K7 RPS6KA4 MAP3K6 MAPK3 TNFSF6 MAP2K4 MAP2K1 MAP2K2 RASGRF1 RELB MAPKAPK2 MAP3K13 NTRK1 GRB2 SOS1 MAP3K2 FLNB HSPA2 PLA2G4B IL1A BDNF DKFZp686L0365 CACNA1H FGF3 FGF4 FGF6 FGF7 FGF8 FGF9 PRKCA ARAF TAOK1 HEL-S-102 NFATC3 RAC3 MELANOMA%WIKIPATHWAYS_20260910%WP4685%HOMO SAPIENS Melanoma PIK3CD PAK1 BRAF KDR AKT3 ARHA PIK3R2 RB1 PIK3R1 CDKN1A CALML6 KIT MAPK1 CALML3 RAC1 CALML4 MAPK3 CDKN2A MAP2K1 RHOB MAP2K2 BAD PTPN11 DDB2 ERBB4 GRB2 SOS1 CALM1 GADD45B GADD45A EXOC7 NRAS GADD45G HRAS GRM3 RAF1 CDK6 PREX2 WHR1 PDE5A CDK4 CCND1 MDM2 BAX SHC2 ARAF HEL114 PIK3R3 PTEN POLK SOS2 E2F2 E2F3 BAK1 NF1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP3A4 CYP7A1 NR1H4 ABCB11 SLC27A5 FGF19 NR0B2 BAAT SLCO2B1 IP6K3 RXRA ABCB4 CYP8B1 UGT2B4 PPARGC1A FKBP5 SULT2A1 THERMOGENESIS%WIKIPATHWAYS_20260910%WP4321%HOMO SAPIENS Thermogenesis ATF2 RPS6KB2 ARID1A FGFR1 ACTG1 CPT2 PS1TP5BP1 CPT1C PPARG MTOR MAPK14 MAPK12 MAPK13 ACSL6 MAPK11 CREB3L2 ACSL5 CREB5 ACSL3 KDM1A PRKG1 SMARCD1 RPTOR SMARCC1 ADCY1 SMARCD2 SMARCC2 RPS6KA6 SMARCD3 ACTL6A KDM3A MLST8 ARID1B CREB1 CREB3L3 RPS6KB1 CREB3L4 ACTL6B SMARCE1 GRB2 SOS1 FRS2 SIRT6 BMP8B TSC1 RPS6KA2 RPS6KA1 CREB3 ADRB3 ADCY3 ADCY6 MAP2K3 AKT1S1 ADCY5 ZNF516 TSC2 PLIN1 HEL-S-7a NRAS MGLL HRAS KDM3B UCP1 ADCY8 ADCY9 DPF1 GNAS DPF3 SLC25A29 BMP8A PRDM16 PPARGC1A FGF21 GCG RPS6 RHEB CPT1A PNPLA2 PRKAB2 PRKAA2 PRKAG1 PRKAG2 MAP3K5 FACL4 SMARCA4 PRKAB1 PRKAG3 SLC25A20 LIPE PRKACG SOS2 CNR1 PRKAA1 ACSL1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome CLTCL1 FGFR2 UFD1L FGF10 FGFR1 POLR2A PARK2 RTN4R CDC42 PAK4 MED15 SREBF2 VWF ACTA2 ALDH1A2 TXNRD2 GP1BA SEPT5 FOXC2 FOXC1 PITX2 PAX3 CDC45 PRODH BCL2 RAF1 SLC2A4 HIRA HIRIP3 HEL-S-80p SHOC2 SERPIND1 SHH FOXA2 GBX2 CRKL EGFR SLC25A1 HES1 DRD2 SNAP29 CYP26A1 NKX2-5 RORC CYP26B1 GLUD1 PLK1 CLDN1 NCOR1 TBX1 HDAC3 CYP26C1 RAN P2RX6 TSKS EMC10 ZDHHC8 RCC1 FGF8 GSC2 C22orf39 CLDN5 CLDN3 THAP7 RTL10 NPRL2 TRMT2A ESS2 HEL25 KLHL22 DGCR8 GP5 DROSHA GP9 LRRC74B SEPT8 MRPL40 DGCR6L H4C9 TNPO1 SCARF2 DGCR2 GP1BB C16orf35 HAND2 RELN SLC7A4 GNB1L DEPDC5 CCDC188 hCG_1641087 ARVCF ASF1A RANBP1 ZNF74 RBX1 RTN4 CDH15 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260910%WP699%HOMO SAPIENS Aflatoxin B1 metabolism HEL-S-166mP CYP1A2 CYP3A4 EPHX1 GSTM1 CYP2A13 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260910%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL31 RPLP1 RPL34 RPLP0 RPL8 RPLP2 RPS6KB2 RPL9 RPL6 RPS4X RPL7A RPL36 RPS15 RPL35 RPS14 RPL37 RPL39 RPS17 RPL21 RPS16 RPL23 RPS19 RPL22 RPS18 RPS3A RPL37A RPL29 RPS11 RPL28 RPS10 RPL10 RPL10A RPS13 RPL12 RPS12 MRPL19 RPL36A RPS4Y1 RPS9 RPL14 RPS7 RPL13 RPS8 RPL15 RPS5 RPL18 RPL17 RPSA RPL19 RPL41 RPL35A RPL23A RPL3L RPS25 RPS27 RPL27A RPL13a RPS26 RPL30 RPS28 RPS29 RPS20 RPS21 RPS24 RPS23 RPS6KA6 RPL38 RPS27A RPS6KB1 RPS6KA2 RPS6KA1 RPS15A RPS3 RPS2 FAU RPS6 RPL5 RPL7 RPL18A RPL27 RPL26 RPL11 HEL-S-310 RPL4 RPL3 RPL32 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260910%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade ZAP70 HLA-DRB1 CD3G NFATC1 CD3E NFAT5 NFATC2 CD3D NFKB1 BATF JUN PDCD1 PDCD1LG2 IFNG NFATC3 HLA-A NFATC4 STAT3 PTPN11 CD8B CD8A LCK MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260910%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ITGB3 LPP TJP1 PRKCQ HEL114 MYLK JUN MAPK1 PXN PLCG1 MFAP5 MAPK3 ACTN1 ITGAV MYL2 CREB1 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260910%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways IKBKB PIK3CD PIK3C2G OPA1 PIK3C2B HMGCR REST MAPK9 SREBF2 MAPK10 HMGCS1 ABCG4 PI3 NR1H2 SLC12A5 RAB3GAP1 ABCG1 HDAC2 CASP3 CREB1 AHI-1 EIF4E NTRK2 TSC2 BCL2 MAP3K10 RAF1 DHCR7 C1QA CYP46A1 EGF BAX RICTOR HTT EIF4EBP1 HEL-S-29 MBP DEPTOR SP1 PTEN APOE SLC12A2 ABCA1 IL1B EGFR MAPK8 CASP8 NFKB1 RPS6KA5 NEUROD1 AKT3 MTOR SIN3A HDAC1 PIK3R2 PIK3R1 MAPK1 BCL2L11 MAPK3 MAP2K4 MAP2K1 MAP2K2 RPTOR BAD MLST8 BNIP3 IL6 RPS6KB1 BCL2L1 TSC1 AKT1S1 BDNF HRAS CYP51A1 PPARGC1A GABRB3 GABRB2 GABRB1 GABRE GABRQ HAP1 GABRA2 RHEB GABRP PRKAB2 GABRA6 PRKAA2 GABRA5 GABRA4 GABRA3 KIF5A GABRG3 PRKAG1 GABRG1 PRKAG2 PRKAB1 PIK3R4 PRKAG3 PIK3R3 PIK3R5 PRKAA1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260910%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B ARHA FGFR2 MAPK11 ROCK1 SOX9 MAPK1 MAP3K1 GADD45G WNT4 AXIN1 FOXL2 SRY FRAT1 FGF9 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260910%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling ATF1 EGR1 MAPK1 RPS6KA5 RAP1A MAPK3 MAP2K1 NR3C1 MAP2K2 MAPKAPK2 GNAS BRAF HTR4 HTR6 CREB1 HTR7 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260910%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc SUCLG2 DLAT PDHA1 SDHA OGDH HEL60 HEL-S-26 ACLY PCK1 PC DLD CS FH HEL-S-32 FOCAL ADHESION%WIKIPATHWAYS_20260910%WP306%HOMO SAPIENS Focal adhesion IBSP TNR RAPGEF1 TNK2 ITGA7 PDGFRA TNK1 ITGA6 COL4A2 TLN1 COL4A1 CRK DOCK1 COL4A4 SHC3 COL4A6 ROCK1 FLNA ROCK2 SRC PXN PIK3CD ACTG1 CDC42 VTN PAK1 RAP1A CHAD PS1TP5BP1 PAK6 COL5A3 PAK4 ACTN1 VASP TNC COL5A2 CAV3 CAV2 ACTN4 BRAF KDR MAPK9 ZYX LAMC2 LAMC1 VWF MAPK10 LAMA5 LAMA1 LAMA4 LAMA3 THBS2 MYLK4 THBS4 MYL11 THBS3 CCND3 MYL5 CCND2 MYL7 TLN2 sm-M20 TXK MYL12A MYL10 SRMS PTK6 PARVB PARVG LAMB3 ARHGAP5 LAMB2 LAMB1 c-fgr JUN BCL2 RAF1 COL2A1 CCND1 EGF IGF1R ERBB2 PPP1CC BIRC2 BIRC3 VEGFC HEL-S-80p SHC4 SHC2 MYL12B ARHGAP35 PTEN IGF1 CRKL EGFR MAPK8 FYN THBS1 MYLK3 HGF MYL2 AKT3 opn GSK3B SHC1 ARHA PDGFA PIK3R2 PIK3R1 MAPK1 RAC1 MAPK3 MAP2K1 EMP2 RASGRF1 FLT1 BLK PARVA BAD VAV1 VEGFA GRB2 SOS1 FLNB HRAS PDGFD PDGFC COL1A1 COL1A2 ITGB1 MYLK2 PRKCB COMP PRKCA ITGB4 ITGB3 ITGA2B HEL114 MYLK PPP1R12C PIK3R3 ITGB8 RELN RAC3 VEGFB ITGAV ITGB7 VEGFD PIP5K1C ITGB6 XB VAV3 ITGA4 PDPK1 ITGA2 ITGA1 HEL-S-28 VAV2 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260910%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA2 LPL VLDLR APOA4 APOE LDLR LIPC SCARB1 PLTP CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260910%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CAMK2A TGFB1 RELA NFKB1 JUND GJA1 FOS NFKBIA GNAO1 STAR GNB2 HSD3B2 GNB1 HSD3B1 BRAF GNB3 MAPK9 CRHR2 GSK3B MAPK14 ARHA MAPK1 PLCG1 TFAP2A CASP9 JUNB JUP CRH MAPK3 CASP3 MAP2K1 TRIM28 CYP21A2 GNA11 CRHBP KRT1 CREB1 IVL GNAZ FOSL2 KRT14 FOSB CXCL8 IL18 CASP12 GNAI1 IL2 BCL2 DKFZp686L0365 RAF1 CACNA1H TLR4 FOSL1 GNAS SULT2A1 PRKCI POMC PRKCB ACACA PRKCA PRKAA2 GNB5 PRKCQ MAP3K5 SP1 ERN1 ECE1 PLCG2 TCF4 CYP11A1 MAPK8 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260910%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts HK3 PGM3 UGDH UXS1 HK2 GFPT1 GCK CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP5304%HOMO SAPIENS Cholesterol metabolism DGAT1 LPA MVD HMGCR APOA2 APOC3 STAR SOAT1 LPL APOA4 DKFZp434B2017 SLC27A4 NPC1L1 LIPC MGAT1 ABCG8 APOC2 ABCG5 ANGPTL8 ANGPTL3 FABP2 SQLE IDI1 PLTP MVK MSMO1 HSD17B7 ACAT2 TM7SF2 FDFT1 MYLIP FDPS HMGCS1 APOH CD36 NPC2 NPC1 LIPA LRPAP1 STARD3 CYP7A1 CIDEB VAPA PBR EBP SC5D CYP51A1 DHCR24 DHCR7 LBR APOC1 MTTP CYP27A1 PCSK9 LIPG SCARB1 APOB ABCB11 APOE LDLR ABCA1 SORT1 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260910%WP3527%HOMO SAPIENS Pre implantation embryo TCF7L1 MACROH2A2 NKX2-1 AQP9 CDX2 EGR1 ATP1A1 GATA3 GATA2 HNRNPAB POU5F1 ZFP42 BATF3 ELAVL1 FOXD1 SIX3 ZFP36 IRX5 AQP3 DNMT3L TEAD4 E2F5 PBX1 SOX11 SOX2 ZFP36L2 FOSB NANOGNB NR3C2 FOXQ1 KHSRP KLF4 ZAR1 ARGFX DPPA3 DDIT3 PADI6 MXD1 BARX2 LEUTX MTA3 TPRX1 MOS HMGA1 DPRX ZSCAN4 TBX3 MYBL1 TFAP2B SOX8 SMARCA4 IRF4 ESRRA DLX2 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260910%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence ELAVL1 SIRT5 RELA GOT2 NMNAT2 SIRT2 SIRT3 NAMPT SIRT1 HMGA1 SLC2A4 IL1B MDH2 PRKAA1 CCL27 HEL-S-32 IL6 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260910%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 PDGFRA SNAI1 NFKB1 FGFR2 EDAR INHBA FZD1 FOXI3 LRP5 CCND1 GTPBP4 GJB6 MYC TNLG7C ITGB1 NCAM1 PDGFA SHH RUNX2 SMO LAMA5 CCND2 BMP4 LEF1 TP63 PTCH1 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260910%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition IRS1 SLC2A4 TBC1D4 INSR MTOR RPS6KB1 RPS6 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260910%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity TGFB1 MBL2 CAP1 C5AR2 PALS1 SERPING1 VTN AXL MFGE8 ATP11A HTRA2 DIABLO CFP CASP9 TNFSF6 CASP3 APAF1 PROS1 CLU C8G C3AR1 ATP10A ATP8B2 HEL-S-62p CR2 CR1 C1QC C8A C4A MASP2 MASP1 CD46 IFNG CFB CFD C1QB CX3CL1 C1QA C1S CFH CASP10 CFI BAX FCN1 C5AR1 CYCS FCN2 C4B_2 PATJ FCN3 C4BPA C6 C4BPB C7 DLGAP5 C9 PRKCI ATP11C CD55 SCRIB PARD6A PLSCR1 PLSCR3 ITGAM PLSCR4 TYRO3 MARK1 ITGB3 LLGL2 CRB2 MBP COLEC12 CRB1 COLEC10 PARD6G CD59 DEDD ATP8B3 MERTK ITGAX COLEC11 PRKCZ PARD3 ITGAV PARD6B ATP8B1 CX3CR1 CASP8 BAK1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260910%WP391%HOMO SAPIENS Mitochondrial gene expression POLRMT GABPB1 PPP3CA CAMK4 PPARGC1B MYEF2 SP1 GABPA MTERF3 TFB2M TFB1M NRF1 PPRC1 HCFC1 ESRRA MTERF1 PPARGC1A CREB1 TFAM ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260910%WP2374%HOMO SAPIENS Oncostatin M signaling RELA NFKB1 EGR1 JAK3 SRC JUND PXN STAT5B FOS NFKBIA MAPK9 MTOR MAPK14 CEBPB SHC1 PIK3R1 SOCS3 CDKN1B MAPK1 JUNB MAPK3 JAK1 CASP3 MAP2K1 MAP2K2 STAT1 STAT3 PTPN11 TYK2 CREB1 VEGFA GRB2 SOS1 IL6ST HRAS RAF1 CDK2 RPS6 RICTOR PRKCH IRS1 PRKCB PRKCE PRKCA PTK2B HIF1A OSMR OSM MAPK8 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260910%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 EHHADH HSD17B10 ACSL3 ACADSB DECR1 ACADL HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260910%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling CSNK1A1 PDGFRA APC FGFR4 FGFR3 RELA NFKB1 FGFR2 IKBKB FGFR1 CSF1R SRC PIK3CD CHUK FOS NFKBIA RETN LRP5 BRAF KDR LRP6 AKT3 MTOR SALL4 GSK3B RARA SHC1 AXIN2 REL CDKN1A KIT MAPK1 PYGO1 JUP IL6R MAPK3 ZBTB16 MAP2K1 RPTOR MAP2K2 FLT1 ULK2 STAT3 MLST8 IL6 NTRK1 GRB2 SOS1 NR1C2 KSR1 TSC1 GAREM2 NTRK2 RUNX1T1 JUN AKT1S1 PML TSC2 HRAS RAF1 EPHA2 CCND1 MDM2 IGF1R MYC NGFR NFKBIE RHEB FOXO1 FLT3 IKBKG DEPTOR FLT4 BCL9 PTEN TTI1 WNT1 TCF3 SOS2 LEF1 EGFR INSR HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260910%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG1 LMO2 HBE1 HBD GATA1 tal-1 HBZ HBA2 HBG2 HBB LDB1 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260910%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR KIFAP3 CEP295 BBS10 BBS12 CCDC41 WDPCP TEDC1 TEDC2 ARL6 FBF1 KATNB1 KIAA0753 TUBD1 KIF3B RAB23 OFD1 CEP76 IFT70B SCLT1 TUBE1 CPLANE2 SASS6 CEP20 CEP162 CIBAR1 CEP44 TCTN3 CLUAP1 TCTN2 TCTN1 BBS9 BBS7 CEP97 BBS5 CC2D2A ARMC9 RPGRIP1L TMEM216 CEP104 ARL3 BBS4 ARL13B TMEM67 INPP5E MKS1 PIBF1 BBS2 MIB1 BBS1 CPLANE1 TMEM231 TTC8 TMEM17 B9D1 TRAF3IP1 CEP19 LZTFL1 DYNC2H1 DYNC2I2 DYNLT1 IFT140 DYNLT2B IFT80 WDR35 KIF3A DYNC2LI1 EVC2 IFT43 IFT81 EVC IFT27 FUZ DNCL1 IFT46 IFT25 IFT20 RABL2B TTC26 IFT172 TTC23 IFT74 C2CD3 CBY1 EFCAB7 IFT52 CEP192 TXNDC15 TMEM107 IFT57 CDK20 TRAPPC11 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260910%WP5174%HOMO SAPIENS Ulcerative colitis signaling TGFB1 IL10 NFATC1 IL2RG TNF FOXP3 NFKB1 GATA3 IL4 IFNG IL5 MAF NOD2 HLA-DMA IL13 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260910%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer POLD3 TYMS DHFR SMC3 SMC2 NPAT HLTF SKP2 PLK4 TOP2A ZNF655 CDC25B RPA1 SAP30 RRM1 SIN3A RRM2 RBP1 HDAC1 FANCG MAPK13 POLA1 RB1 CDKN1A CDKN1B POLE2 CCNA2 RPA3 TTK CCND3 CHEK1 HMGB2 SMC1A MCM7 ORC1L CCNE2 TFDP1 TFDP2 CCNE1 MCM3 CCNB2 MCM6 CCNB1 PRIM1 CDC45 HMGB1 CDC2 WEE1 SUV39H1 RAF1 CDK6 CDK4 CDK2 CCND1 MDM2 MYC BARD1 CCDC6 RBBP7 PRKDC CDT1 PCNA POLE RFC3 RFC4 RBBP4 H2AZ1 E2F2 PRMT2 MSH6 E2F3 FAF1 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260910%WP4271%HOMO SAPIENS Vitamin B12 disorders TCN2 TCN1 CUBN AMN CBLIF MTRR MMAA MMACHC MMADHC MTR CD320 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome SOCS1 GATA3 POLR2F POLR2H CSF2 POLR2K POLR1A POLR1D ANAPC1 CHTM1 POLR2L ZC3H8 PSD4 ARL14 CKAP2L POLR1F POLR1G IL36A IL23A POLR1H IL36B FBLN7 TMEM87B SLC20A1 SOCS3 RGPD8 MAPK1 IL36G RAC1 TULP1 BCL2L11 TTL NT5DC4 IL1F10 STAT1 CSF1 IL6 ARF6 GRB2 IL37 CXCL13 IL1R1 IL2 IL36RN IL1A POLR1C IL1RL2 MERTK PLCG2 IL1B IL1RN COPPER HOMEOSTASIS%WIKIPATHWAYS_20260910%WP3286%HOMO SAPIENS Copper homeostasis STEAP3 MTF1 MT1F MT1G APC MT1B MT1E PRNP ADAM9 JUN BACE1 MT2A STEAP4 CCND1 MDM2 CCS ADAM10 GSK3B FOXO1 APP FOXO3A COX17 SP1 ATP7B SLC31A1 ATP7A SLC31A2 ADAM17 PTEN COMMD1 CASP3 ATOX1 SCO1 XAF1 STEAP1 STEAP2 MT4 COX11 MT3 SLC11A2 HEL-S-44 MT1A OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis FADS1 ELOVL2 ELOVL5 FASN ELOVL3 ACSL3 FACL4 SCD ELOVL1 SCD5 ELOVL6 FADS2 ACSL1 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome MDC1 RAD50 SMC3 PAXIP1 RAD21 NBN MRE11A SMC1A RAD18 ATM INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260910%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition IRS1 SLC2A4 TBC1D4 INSR MTOR RPS6KB1 RPS6 IL9 SIGNALING%WIKIPATHWAYS_20260910%WP22%HOMO SAPIENS IL9 signaling IL9 GRB2 IL2RG PIK3R2 PIK3R1 MAPK1 JAK3 STAT5B MAPK3 JAK1 MAP2K1 MAP2K2 STAT1 CDK9 IL9R STAT3 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260910%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly TACO1 HIGD1A PET117 COX14 COA6 COX10 PET100 COX6A1 FAM36A CMC1 TMEM177 PNKD SMIM20 COX6B1 COX7A2 COA3 COX3 COX2 COX7B COX7C COX1 COX8A COX5A COX17 SURF1 COX19 COX16 COX11 COX18 COXFA4 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260910%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway EZR HEL70 ARHA MYL2 OCRL SEPTIN2 RDX RAB35 KIF23 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP75%HOMO SAPIENS Toll like receptor signaling LY96 RIPK1 FADD CD80 TICAM1 IRAK4 RELA NFKB1 IKBKB TRAF6 CHUK FOS NFKBIA TICAM2 TIRAP IRAK1 IL12B TLR1 MAP3K8 TLR9 MAP3K7IP1 TAB3 MAPK9 MYD88 AKT3 IFNB1 opn MAPK14 IFNA6 MAPK12 MAPK13 MAPK10 LBP MAPK11 TLR5 CCL4 MAPK1 RAC1 CCL3 MAP3K7 MAPK3 MAP2K4 MAP2K1 MAP2K2 STAT1 CXCL9 IFNA1 TRAF3 IL6 CD14 IRF7 CXCL8 IFNA2 MAP2K6 MAP2K3 JUN IFNA13 IFNA14 IFNA16 TLR8 IL12A IFNA17 TLR7 IFNA10 CD40 TLR4 TLR3 IFNA21 TBK1 IFNAR2 IKBKE CXCL11 IFNA5 IRF3 IFNA4 IFNA8 IFNA7 TNF IFNAR1 NFKBIB IKBKG IL1B CCL5 MAPK8 CASP8 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy IBSP FOSL2 COL10A1 FOSB FGFR4 FGFR3 RELA NFKB1 FGFR2 FGFR1 JUN JUND CNMD FOS P4HTM GANC CTGF LAMTOR1 DDR2 FOSL1 COL2A1 VHL KDR AKT3 opn COL1A1 CEBPB PRKCA NGF RUNX2 HIF1A SOX9 MAPK1 FGF23 JUNB MAPK3 RELB ACAN STAT3 COL3A1 NTRK1 VEGFA GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA5 B4GALNT1 HEL-S-111 ST3GAL1 ST8SIA6 HEXA NEU3 ST8SIA1 NEU4 B3GALT4 ST3GAL5 SIAT4C BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260910%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome HMGA1 G6PC2 G6PC3 MAPK9 CRP MAPK14 MAPK12 ACACA MAPK13 MAPK10 PRKAB2 MAPK11 PRKAA2 MAPK1 PRKAG1 PRKAG2 ACACB PCK2 PRKAB1 PRKAG3 MAPK3 G6PC1 ACLY SLC27A2 PRKAA1 MAPK8 AGE RAGE PATHWAY%WIKIPATHWAYS_20260910%WP2324%HOMO SAPIENS AGE RAGE pathway ATF2 IRAK4 RELA NFKB1 IKBKB ROCK1 SRC CDC42 STAT5B CHUK NFKBIA TIRAP NOS2 MAPK9 MYD88 MMP2 MMP9 SMAD2 MAPK14 SHC1 ARHA MAPK1 RAC1 CASP9 MAPK3 MMP7 CASP3 MAP2K1 STAT1 STAT3 MMP14 INHBB JUN ALPL EZR RAF1 DDOST NCF1 MSR1 CYCS IRS1 PRKCB PRKCA FOXO1 INS HIF1A SP1 PRKCZ HEL70 EGFR AGER INSR FOXO4 MAPK8 CASP8 HEL-S-44 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260910%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD CYP1A2 RELA NFKB1 PLAGL1 EP300 RET SRC PTGS2 NRAS HRAS NQO1 GCLC RAF1 CYP1A1 LPL CDK2 CDC37 MYC AIP KLF6 FGF21 CYP1B1 TNF RB1 CDKN1A CDKN1B MAPK1 CD36 MAP2K1 NCOR2 NFE2L2 AHRR EGFR AHR CCL1 VEGFA NF1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260910%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TGFB1 SNAI1 SNAI2 HDAC1 ZEB2 SUZ12 TWIST1 ELF3 PRRX1 HDAC2 KDM1A SUV39H1 SIRT1 TCF4 EZH2 SIX1 KLF8 ELF5 FOXC2 GSC2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260910%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling CCNE1 RPS6KA1 ADCY3 MAP2K6 MAP2K3 SRC GNAI3 GNAI1 RAP1A HRAS RBL2 RAF1 GNAO1 CDK4 GNB1 CDK2 GNAS PLCB1 BRAF IGF1R CGA KCNIP3 MTOR RPS6 TSHR SCRIB MAPK14 GNA13 PIK3R2 RB1 PIK3R1 PDE4D CDKN1B MAPK1 MYL12B APEX1 MAPK3 CCND3 JAK1 GNG2 MAP2K1 STAT1 STAT3 RAP1GAP PDPK1 CREB1 TSHB RPS6KB1 ERYTHROPOIESIS%WIKIPATHWAYS_20260910%WP5607%HOMO SAPIENS Erythropoiesis HBG1 IL3 HBE1 GATA1 PTPRC IL3RA CD79A KIT HBB GATA2 TNFSF6 HBD TF TFRC EPO HBZ KITLG CD34 HBA2 HBG2 EPOR GDF11 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260910%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases HEL-S-68p KHK H2AX STAT3 MYL2 H3F3B AKT1S1 HEL-S-30 SNAP23 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260910%WP5461%HOMO SAPIENS Primary ovarian insufficiency FMR1 SPIDR EIF2B1 SIX6OS1 EIF2B5 HAX1 SLX4 CCDC185 MGME1 C10orf2 BMPR1A MND1 CENPE NLRP11 XPNPEP2 BMPR2 RECQL4 SPATA33 WRN RFWD3 FANCM FANCL CLPP FANCA SALL4 POLR3H LAMC1 NUP107 FOXL2 NBN NR5A1 WT1 AMH BMP6 AMHR2 ZAR1 PCCA PCCB BMP15 RAD51 ATM BLM PGRMC1 NR3A2 SOX8 ATG9A POLR2C BRCA2 TP63 LMNA TGFBR3 EIF4ENIF1 STAR POLG PSMC3IP FIGLA DAZL FSHR MSH5 DMC1 ZP3 COX10 CYP17A1 ALOX12 DCAF17 PPM1B GNAS HSD17B4 HSD17B1 EIF2B2 PRORP ANTXR1 MSH4 MEIOSIN POF1B MEIOB SIL1 NANOS3 LARS2 PREPL STRA8 NOBOX KHDRBS1 AARS2 NOTCH2 AIRE MST1R HMMR WDR62 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 HELQ ERAL1 DIAPH2 STAG3 H1-8 MCM9 HROB LHX8 BNC1 MCMDC2 ELAVL2 C1orf146 MRPS22 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260910%WP51%HOMO SAPIENS Regulation of actin cytoskeleton PDGFRA FGF18 F2R FGFR4 ARHGEF7 FGFR3 FGFR2 CRK DOCK1 FGF10 FGFR1 ROCK1 ROCK2 NCKAP1 PXN PIK3CD BDKRB2 ACTG1 MYH10 PIK3C2G CDC42 RASSF7 PAK1 ARPC5 PIK3C2B SSH2 SSH3 PS1TP5BP1 PAK6 SSH1 FGF14 CSK BRK1 PIP5KL1 PAK4 CHRM4 ACTN1 ARHGEF4 CHRM5 FGD1 WASF2 ABI2 BRAF FGF13 FGF12 MAPK6 MAPK4 WAS MYL1 MYL3 PIP4K2A CD14 EZR RAF1 MOS EGF FGF2 GNA13 CYFIP2 BDKRB1 ARHGEF1 FGF20 FGF23 FGF22 FGF17 FGF16 FGF19 PFN1 ARHGAP35 HEL70 APC2 RRAS2 SOS2 CHRM3 EGFR F2 RRAS TMSB4X APC BAIAP2 ARHA PDGFA PIK3R2 PIK3R1 MAPK1 RAC1 MAPK3 MAP2K1 MAP2K2 WASF1 CHRM1 VAV1 SOS1 HEL-S-15 RDX NRAS FGF3 FGF4 FGF6 FGF7 FGF21 FGF8 IQGAP1 FGF9 GNG12 CFL2 LIMK1 HEL114 MYLK STM7 PIK3R4 PIK3R3 PIK3R5 PIP5K1A RAC3 PIP4K2B PIP5K1C CHRM2 ITGA1 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response RAD52 CCND3 CDK6 CCNE1 CCND1 H2AX CDKN1A MYC CDKN1B ATM CREB1 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP4149%HOMO SAPIENS White fat cell differentiation TCF7L1 CEBPA NR1H3 TLE3 EGR2 KLF5 CEBPD KLF4 ZNF423 GATA3 STAT5B GATA2 KLF15 DDIT3 KLF2 EVI1 PPARG CTNNA1 RORA IRF3 CEBPB RARA FOXO1 INS IRF4 NR2F2 NR3C1 WNT10B CREB1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260910%WP1971%HOMO SAPIENS Integrated cancer pathway MSH2 ATF1 MRE11A CDKN2B CDC2 BCL2 RAD50 CDK4 CDK2 MDM2 BAX MYC CDC25B ATM BLM BARD1 ATR NOXA1 SMAD2 PLK1 RB1 CDKN1A CDKN1B BBC3 MAP3K5 CASP9 JAK1 PTEN CHEK2 POU2F1 CASP3 CHEK1 STAT1 BAD BACH1 MSH6 CASP8 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260910%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TGFB1 SMAD2 APC TGFBR2 TGFBR3 TGFA NRAS TGFBR1 TSPAN8 HRAS RAF1 MFGE8 WNT3A AXIN1 DKK4 CD133 SMAD4 HGF EGFR ERBB2 MTOR PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases RRM1 DHODH RRM2B RRM2 ABAT OTC TYMS AGXT2 DPYD NT5C3A DPYS CAD HEL74 UMPS TYMP GLS2 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260910%WP2878%HOMO SAPIENS PPAR alpha pathway NR1H3 CPT1A CYP7A1 CYP4A11 EHHADH SLC27A1 CDC2 UGT1A9 CPT2 DBI ACADM APOA2 APOC3 CDK4 FABP1 APOA5 RXRA CCND1 CYP8B1 MYC KLK15 NR1C1 PLTP GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260910%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein SLC5A1 PCSK1 GCG SLC2A2 MIRNA BIOGENESIS%WIKIPATHWAYS_20260910%WP2338%HOMO SAPIENS miRNA biogenesis RAN XPO5 DICER1 DGCR8 TARBP2 DROSHA BLADDER CANCER%WIKIPATHWAYS_20260910%WP2828%HOMO SAPIENS Bladder cancer FGFR3 CXCL8 SRC THBS1 RPS6KA5 DAPK2 NRAS HRAS RAF1 CDK4 CCND1 MDM2 EGF BRAF MYC ERBB2 UPK3A MMP2 MMP9 PIK3R2 RB1 PIK3R1 ARAF CDKN1A MAPK1 CDKN2A MAP2K1 MAP2K2 EGFR RASSF1 HBEGF TYMP VEGFA CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260910%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway TRADD RIPK1 FADD ISG15 AIM2 IL33 RELA NFKB1 IKBKB CHUK POLR2F POLR2H NFKBIA POLR2K POLR3B POLR3D POLR3E POLR1D ZBP1 POLR3GL IFNB1 POLR3A POLR3H POLR2L POLR3C POLR3F POLR3K POLR3G IFNA6 CCL4 IFNA1 PYCARD DKFZp686F0183 TREX1 IL6 IRF7 IFNA2 CCL4L2 IL18 CGAS ATG12 IFNA13 IFNA14 IFNA16 IFNA17 POLR1C IFNA10 IFNA21 TBK1 CASP10 TRIM25 IKBKE MITA RNF125 IFNA5 ADAR IRF3 IFNA4 IFNA8 IFNA7 NLRX1 CYLD MAVS NFKBIB IKBKG RIGI IL1B CCL5 CASP8 RIPK3 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260910%WP5526%HOMO SAPIENS Age related macular degeneration PMAIP1 PRKAB2 PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 MAPK3 SIRT1 RPTOR PARP2 PPARGC1A MLST8 PRKAA1 HEL-S-32 MTOR RPS6KB1 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260910%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation TBXA2R PTGES PTGER1 PTGDR PTGIR PTGER3 PTGS2 PTGS1 PTGIS AKR1C1 AKR1C2 PPARG AKR1B1 PRL EDN1 HSD11B1 HSD11B2 HEL-S-7 PPARGC1A ANXA6 PTGFRN S100A10 ANXA2 ANXA3 ANXA4 SCGB1A1 SOX9 PPARGC1B S100A6 EDNRA EDNRB ANXA1 PTGER4 CYP11A1 PTGER2 PTGFR HPGD P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260910%WP4963%HOMO SAPIENS p53 transcriptional gene network MSH2 ISG15 XPC GPX1 THBS1 CCL2 TP53INP1 CPT1C MTOR NCF2 GLS2 SESN2 SMR3B CDKN1A ACAD11 SERPINB5 SCO2 BBC3 ADGRB1 AURKA TP53AIP1 DRAM1 PIDD1 ZMAT3 BTG2 PERP ERCC5 E2F7 TNFSF6 RPRM SIVA1 SESN1 ULBP2 RPTOR ULBP1 ULK2 APAF1 ULK1 MLST8 DDB2 RRM2B TNFRSF10D CCNE1 TIGAR SLC7A11 PMAIP1 SFN GADD45A AKT1S1 TNFRSF10B PML TSC2 TP53I3 ADORA2B CX3CL1 DDIT4 CCNG1 CDK2 BAX TRAF4 FUCA1 IRF9 TNF PRKAB2 PRKAA2 PRKAG1 PRKAG2 DEPTOR NOTCH1 PRKAB1 PRKAG3 PCNA LIF XRCC5 PTEN POLK PRKAA1 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5275%HOMO SAPIENS Ether lipid biosynthesis CEPT1 FAR1 GNPAT LPIN1 LPIN3 LPIN2 PEX16 ALDH3A2 PEX19 LPCAT1 PEDS1 PEX7 UGT8 PEX5L PEX3 DHRS7B AGMO ACAD10 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260910%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HIPK1 HIPK2 CDKN1B HMBOX1 G13 SIGNALING%WIKIPATHWAYS_20260910%WP524%HOMO SAPIENS G13 signaling RTKN SH3RF1 TNK2 RHPN2 MYBPH CIT CALM1 ROCK1 ROCK2 PIK3CD HEL-S-15 CDC42 ARHGDIG IQGAP1 HEL-S-80p CFL2 WAS GNA13 MAPK10 ARHA ARHGEF1 PIK3R2 LIMK1 RAC1 MYL1 PKN1 PFN1 ARHGDIB PIP4K2A WASL CYFIP1 RPS6KB1 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260910%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGB1 SELPLG ITGB7 VCAM1 SELE ITGA4 ITGA2 MADCAM1 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260910%WP2197%HOMO SAPIENS Endothelin pathways NPY1R CALM1 HEL-S-14 PTGIR RIIAD1 ATP2A2 RAMP1 GNAI1 HEL-S-7a RAF1 COX2 ADRB1 GNAS PLCB1 NPY EDN1 CALCRL CAD GNG13 CALCA PRKCA ADRA1A GNB5 MYLK MAPK1 MYL1 EDNRA EDNRB ECE1 MAP2K1 GNA15 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260910%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAP2K1 MAP2K2 MAFF NFE2L2 MAFG CYP2E1 MAFK MAPK8 SP1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260910%WP438%HOMO SAPIENS Non homologous end joining XRCC5 POLL NHEJ1 POLM WRN PRKDC CILIOPATHIES%WIKIPATHWAYS_20260910%WP4803%HOMO SAPIENS Ciliopathies IQCB1 KIAA0753 CCDC40 GLI3 OFD1 ANKS3 INVS CLUAP1 BBS4 USP9X XPNPEP3 MKS1 AHI-1 ODAD1 ODAD3 ODAD4 CCDC28B NEK9 MCIDAS TBC1D32 NEK1 NEK2 DNAAF3 CFAP418 DNAAF2 DNAAF6 CEP19 CFAP410 FAM161A PKD1 CCNQ CCNO AK7 PKHD1 CEP78 DCDC2 DNAAF19 ARL2BP DNAL1 RSPH1 DNAAF11 HYDIN CCDC39 DNAI2 EVC2 CFAP52 TOPORS RP1 KIF7 NME7 EVC NME9 EFHC1 WDR51B ZMYND10 KIZ CFAP53 SDCCAG8 KATNIP DNAH6 PKD1L1 CFAP298 POC1A RAB28 IFT172 DNAI1 TUB DYX1C1 PCARE C2CD3 RPGRIP1 RP1L1 CENPF TTLL5 TMEM107 SPAG1 HYLS1 ATXN10 TRIM32 BBS10 BBS12 CCDC41 GPR161 WDPCP ALMS1 ARL6 ZNF423 RAB23 SCLT1 PLK4 CEP164 DNAJB13 TCTN3 SUFU TCTN2 TCTN1 BBS9 BBS7 BBS5 CEP290 CC2D2A RPGRIP1L TMEM138 RP2 TULP1 TMEM216 CEP104 ARL3 ARL13B TMEM67 INPP5E NPHP1 CRX PDE6D NPHP3 PIBF1 BBS2 NEK8 BBS1 CPLANE1 TMEM231 TTC8 TMEM17 TMEM237 RSPH9 UNC119 B9D1 CEP41 B9D2 ADCY6 ZIC2 RSPH3 TRAF3IP1 LZTFL1 DYNC2H1 DYNC2I2 INTU IFT140 DYNLT2B IFT80 HEL-S-296 WDR35 DYNC2LI1 IFT43 IFT81 SMO IFT27 BBIP1 DRC1 PIK3R4 FLCN CNGA1 OCRL IFT52 IFT57 CNGB1 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP3995%HOMO SAPIENS Prion disease pathway HEL-S-269 RFX5 PRNP SPI1 NFKB1 FGFR1 HEL-S-89n EP300 CASP12 HEL-S-125m BCL2 MEF2C SMC3 TBP RXRA PAX5 CTCF NCAM1 RAD21 BATF MAPK1 IRF4 MAPK3 CHD2 POU2F2 CASP3 STAT3 FYN CREB1 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260910%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis RICTOR PTEN RIOK2 RIOK1 RPL11 FOXO3A EGFR MLST8 MAPKAP1 AKT3 MTOR MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260910%WP3877%HOMO SAPIENS MYD88 distinct input output pathway NFKB1 TLR5 TRAF6 TIFA JUN UBE2V1 IL1A TLR8 HEL-S-71 TLR7 IRAK1 TLR4 TLR1 TLR9 MYD88 TLR10 PI3K AKT SIGNALING%WIKIPATHWAYS_20260910%WP4172%HOMO SAPIENS PI3K Akt signaling ITGA7 FGF18 ITGA6 FGFR4 FGFR3 FGFR2 FGF10 FGFR1 PIK3CD PCK1 IFNB1 IL3 IL7 IFNA6 MCL1 CDKN1A CDKN1B CASP9 CCND3 CCND2 CREB1 CREB3L3 CCNE2 CREB3L4 CCNE1 ATF6B NTF4 FLT3LG TSC2 IFNA13 IFNA14 RBL2 IFNA16 CDK6 IFNA17 IFNA10 CDK4 COL2A1 IFNA21 CDK2 CDC37 MDM2 PRL ANGPT2 ANGPT1 VEGFC RPS6 PRLR IFNA5 IFNA4 IFNA8 IRS1 EIF4EBP1 INS GNB5 LAMB4 INSR CSH2 IL2RG NFKB1 COL6A1 COL6A6 COL6A5 PIK3AP1 THBS1 IL2RA IL2RB CSF3 HGF LPAR1 opn PDGFA TGFA RPTOR IFNA1 CSF1 ATF4 MLST8 VEGFA TSC1 CREB3 NRAS HEL-S-125m TCL1B HRAS TCL1A PPP2R1B PPP2R1A KPG_010 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 PDGFD PDGFC FGF21 NGFR GNG12 MYB GNG11 GNG13 COL1A1 COL1A2 IFNA7 RHEB GNGT1 GYS2 GYS1 PRKAA2 GNGT2 FLT3 IKBKG PKN3 OSMR PHLPP2 PKN2 PHLPP1 PKN1 PPP2CA RELN VEGFB OSM VEGFD XB CSHL1 KITLG GHB3 CHRM2 PRKAA1 CSF3R STK11 IBSP TNR PDGFRA ATF2 F2R COL4A2 RELA COL4A1 IKBKB EIF4E1B COL4A4 COL4A6 JAK3 CSF1R CD19 EFNA4 VTN CHUK CHAD EFNA1 NTF3 EFNA3 FGF14 EFNA2 EPO GNB2 TNC GNB1 GNB4 GNB3 IL7R FGF13 KDR FGF12 HSP90AB1 LAMC2 LAMC1 GHR VWF PPP2R5B PPP2R5A PPP2R5D NGF CREB3L2 IL3RA CREB5 LAMA5 KIT LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 GNG3 GNG2 GNG5 GNG4 PPP2R3C GNG7 EFNA5 GNG8 EIF4B ANGPT4 LAMB3 LAMB2 LAMB1 PPP2R3A EPOR PPP2R2C PPP2R2B PPP2R2D GHB2 EIF4E NTRK2 BCL2 RAF1 CCND1 EGF MYC IGF1R FGF2 FGF20 FGF23 FGF22 FGF17 SYK FGF19 FLT4 PTEN IGF1 SOS2 EGFR RPS6KB2 IGF2 AKT3 MTOR GSK3B PIK3R2 PIK3R1 PPP2R5E FOXO3A PPP2R5C MAPK1 RAC1 BCL2L11 PCK2 IL6R MAPK3 JAK1 G6PC1 TNFSF6 COL4A3 COL4A5 MAP2K1 MAP2K2 FLT1 BAD CHRM1 IL6 SGK2 NTRK1 RPS6KB1 GRB2 SOS1 BCL2L1 IFNA2 IL2 IL4 BDNF SGK1 TLR4 G6PC2 G6PC3 FGF3 FGF4 IFNAR2 FGF6 FGF7 FGF8 PPP2R2A FGF9 GH1 PPP2R3B ITGB1 COMP IFNAR1 PRKCA ITGB4 COL9A1 ITGB3 COL9A3 ITGA2B COL9A2 PIK3R3 ITGB8 PIK3R5 ITGAV ITGB7 ITGB6 ITGA4 PDPK1 ITGA2 ITGA1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260910%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADRA2B ADRA2A ADCY3 ADCY6 ADCY5 HEL-S-7a ADCY8 ADCY9 ADCY1 ADRB2 ADRB1 ADRA1D ADRA2C H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer SOX4 CDK4 PMAIP1 RB1 CCND1 CDK8 CSRP2 MED1 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CBS CTH pcap HEL-S-182mP HEL-S-61p ADK CDO1 MAT1A MTR NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260910%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis CARM1 NOS2 PRMT6 HEL-S-277 PRMT7 PRMT2 PRMT1 PRMT3 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation HEL-S-93 DDC DCTN1 DCTN6 DCTN4 NDEL1 DBH YWHAQ HEL-S-1 DISC1 DCTN5 DCTN3 HEL-S-77 HEL2 PPP2CA CDK5 TH PAFAH1B1 DYNC1H1 YWHAG 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome FZD9 HEL-S-162eP USF1 UBE2E1 ABHD11 BCL7B BRD4 BUD23 GTF2I EIF2A VPS9D1 UBE2E3 NRG1 VPS37C VPS37D VPS37A VPS37B LAT2 CLIP2 METTL27 VAMP2 FKBP6 VPS28 ATPAF1 SMARCA5 TRIM50 DEK TSG101 BAZ1B ATP8 FBLN2 FBLN5 MVB12A FBN1 HOXC8 CLASP2 TMEM270 RB1 TBL2 H2AX CLDN1 GTF2IRD1 UBE2L6 OGDH CHTF18 NUP62 MAPK3 HDAC2 ATP5G1 PRKG1 HDAC3 HEL-S-271 ULK1 ATF4 CDKN1C GRB2 DDX21 HSPA2 MYO1C MYBBP1A ATP6 HEL-S-15 SQSTM1 ATP5MC2 ATP5MC3 HEL-S-123m DLD HMGA1 STX1A MYC ATP5PB CLDN5 PKLR CLDN3 ATP5F1D ATP5F1E ACACA CLASP1 ATP5PO LIMK1 MLXIPL GRIP1 ACACB PCNA ATPAF2 CLDN4 BTK SNAP25 RFC2 CLTC EIF4H TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260910%WP2333%HOMO SAPIENS Trans sulfuration pathway GCLM CBS CTH pcap MTR GLUCURONIDATION%WIKIPATHWAYS_20260910%WP698%HOMO SAPIENS Glucuronidation UGT2B7 UGT2B11 UGT2B15 UGT2B17 UGDH UGT2A2 UGT2A1 UGT2B28 UGT1A8 UGT2B10 UGT1A5 PGM2 UGT1A4 PGM5 UGT1A3 UGT1A1 UGT1A9 UGT1A7 PGM3 UGT1A10 UGT2B4 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260910%WP5166%HOMO SAPIENS Glyoxylate metabolism HOGA1 PRODH2 GOT2 AGXT SLC26A1 PXMP2 DAO HEL-S-133P HAO1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260910%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance MAFA EIF2AK2 IRS1 TRAF1 TNF TNFRSF1A INS PIK3R1 CD36 PRKAG3 ERN1 PRKCZ PPP2CA PDX1 SLC2A4 INSR MAPK8 ACSL1 RPS6KB1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260910%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells opn MMP9 CD63 BIRC5 HEL-S-102 CD81 PTEN ETS2 IGF1 TLR4 GATA4 EGF STAT3 EGFR KDR IL6 HEL-S-44 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260910%WP3944%HOMO SAPIENS Serotonin and anxiety related events PLEK FOS PLCD4 NLGN1 HTR1A PRKCB ARC HTR2A PPP3CA CRH BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260910%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 SGPP2 SGPP1 SPHK2 SPHK1 KDSR SPTLC2 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260910%WP5053%HOMO SAPIENS Development of ureteric derived collecting system TGFB1 FST BMPR1A RET BMPR2 CELSR1 GLI3 SIX1 CCND1 SALL1 SIX2 NR1B3 SPRY1 RARA RARB DCN SHH PAX2 SMO ANOS1 GRIP1 HOXD11 HOXA11 ETV4 BMP7 ETV5 EYA1 BMPER GPC3 CRIM1 BMP4 CTDNEP1 GDNF SMAD1 BMP2 FRAS1 FREM1 FREM2 BMP5 GDF11 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260910%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis ENO1 HK3 HEL-S-68p ALDOB HEL-S-162eP FBP1 HEL-S-49 PFKM PGAM1 PCK1 HEL-S-87p DLD SLC2A4 PGAM2 MDH2 HEL-S-32 SLC2A2 MPC1 GCK PKLR HEL-S-281 GOT2 DLAT PDHA1 SLC2A3 G6PC1 PC ENO2 ENO3 MPC2 HEL-S-30 HK2 PFKL PFKP HEL-S-133P FBP2 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260910%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NFKB1 RELA IL1B TRAF3 PYCARD NLRP3 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260910%WP167%HOMO SAPIENS Eicosanoid synthesis PLA2G5 PLA2G6 PTGES ALOX15 PLA2G4B ALOX12 LTC4S PTGS2 PTGS1 ALOX5 PTGIS ALOX15B PRXL2B ALOX5AP RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260910%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CREB3L4 CAMK1D CAMK2A CAMK1G ATF2 ATF1 CALM1 ATF6B CAMK2G CREB3 CTSG CYP11B2 ITPR2 STAR CAMK1 HSD3B2 HSD3B1 PLCB2 AGTR1 AGTR2 CREB3L2 CREB5 CAMK4 CALML6 CALML3 CALML4 CMA1 CYP11A1 CYP21A2 ATF4 CAMK2D REN CREB1 CREB3L3 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260910%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma GRB2 SOS1 RHEB TSC1 TGFA JAK3 TSC2 NRAS HRAS JAK1 RAF1 PTEN RPTOR EREG SOS2 EGF STAT3 BTC TYK2 AKT3 MTOR FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism ACLY ACADM MTTP ESRRA SLC2A4 APOB PPARGC1B HADHB NR1C1 STK11 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260910%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRF7 RIPK1 TICAM1 IRAK4 IRAK3 CXCL8 NFKB1 IKBKB INPP5D TRAF6 CHUK NFKBIA IRAK1 TIRAP TLR4 TBK1 MAP3K7IP1 MYD88 IKBKE IFNB1 TRAM1 IRF3 TNF IKBKG MAP3K7 TRAF3 IL6 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260910%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1C CHRNB4 CACNA1G CHRNA3 RANKL RANK SIGNALING%WIKIPATHWAYS_20260910%WP2018%HOMO SAPIENS RANKL RANK signaling PAPSS2 CBL TRAF1 SPI1 RELA NFKB1 TNFRSF11B IKBKB NFKB2 MAP2K6 TRAF6 SRC JUN TRAF2 CDC42 CHUK SQSTM1 GAB2 FOS NFKBIA MAP3K7IP1 MAPK9 TNFSF11 MTOR MAPK14 NFATC1 PIK3R2 PIK3R1 TRAF5 IKBKG FHL2 MAPK1 RAC1 PLCG1 MAP3K7 LYN MAPK3 SYK MAP2K1 RELB STAT1 TRAF3 MAPK8 TNFRSF11A DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260910%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism SLC44A1 CHDH ALDH7A1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260910%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis EPHA4 RIPPLY2 TBX6 MESP2 LFNG HES7 DLL3 NOTCH1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260910%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria SLC25A5 SLC25A6 SLC25A4 ATP8 COX17 NDUFA11 SURF1 NDUFA10 ATP5G1 HEL-S-271 SCO1 NDUFC2 NDUFC1 NDUFS8 NDUFS6 NDUFS5 NDUFS4 NDUFS3 ND1 NDUFS1 COX11 COXFA4 ND3 ND2 ND5 ND4 ND6 ATP5IF1 NDUFB9 NDUFA12 SLC25A14 NDUFB8 COX6A1 NDUFB7 SLC25A27 COX6A2 NDUFB10 UCP3 NDUFB6 UCP2 SDHC NDUFB5 SDHD NDUFB4 SDHA ATP6 UQCRB NDUFB2 SDHB ATP5MC2 COX6B1 ATP5MC3 COX7A2L ATP5J UQCR11 NDUFB1 UQCR10 UCP1 COX7A2 ATP5H CYB HEL-S-123m COX7A1 UQCRH COX3 NDUFV3 COX2 NDUFV2 UQCRQ ATP5MG COX7B UQCRC1 ATP5MF UQCRFS1 ATP5ME COX7C COX1 NDUFA9 DMAC2L COX8A UQCRC2 NDUFA7 NDUFA6 NDUFB3 NDUFA5 COX5A ATP5PB NDUFA3 NDUFA2 ZNF183 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO NDUFA13 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260910%WP531%HOMO SAPIENS DNA mismatch repair MSH2 POLE4 POLD3 POLD4 POLE2 RPA3 POLE3 PCNA POLD2 PMS2 POLE RFC3 RFC4 LIG1 RFC2 RFC1 RPA1 MSH6 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling GRB2 RAPGEF1 SOS1 CRK DOCK1 SRC PTGS2 JUN PXN PAK1 RAP1A HRAS FOS RAF1 HGF ITGB1 PTK2B MAPK1 MAPK3 PTEN MAP4K1 MAP2K1 MAP2K2 CRKL STAT3 PTPN11 MAPK8 ITGA1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260910%WP4537%HOMO SAPIENS Hippo YAP signaling TEAD2 STK38L YAP1 TNIK HEL-S-31 LATS2 MAP4K3 TEAD3 TEAD4 MAP4K1 MAP4K2 NF2 LATS1 WWTR1 RASSF1 MINK1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260910%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy MAP1LC3A ATG3 RB1CC1 ATG10 WIPI1 ZFYVE1 ATG12 ATG16L2 PIK3R4 ATG16L1 ULK2 ULK1 MTOR DKFZp686F0183 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260910%WP272%HOMO SAPIENS Blood clotting cascade F2 HEL-S-78p F10 F7 VWF F13B SERPINF2 SERPINB2 F3 F5 F8 F9 KLK1 KLKB1 F11 PLAT PLG FGA MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260910%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling KLK3 GRB2 SOS1 GSK3B NFKB1 FOXO1 PDGFA CDKN1A IKBKG CDKN1B MAPK1 CASP9 BCL2 NFKBIA RAF1 MAP2K1 CREBBP MAP2K2 BAD CCND1 MDM2 AKT3 MTOR LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer TCF7L2 FZD9 TCF7L1 CSNK1A1 FZD8 MACROH2A2 APC CSNK1A1L WNT2B SOX17 CER1 CTNNBIP1 SFRP5 ATF3 CTBP2 PORCN WNT16 FZD1 KREMEN1 SENP2 FZD3 LRP5 WNT3A CXXC4 WNT7A NKD1 NKD2 WNT3 WIF1 LRP6 NOTUM CHD8 WNT7B GSK3B AXIN2 SFRP1 NLK TFAP2A MAP3K7 CDK8 CCND3 CCND2 DKK2 EZH2 DKK4 hCG_2014051 JUN DKK1 RUVBL1 SOST CDK6 FOSL1 FZD10 CCND1 MYC FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 WNT5B CSNK2B DVL1 DVL2 DVL3 CTBP1 RYK ROR1 WNT1 ROR2 WNT4 APC2 TCF3 AXIN1 WNT10B LEF1 WNT10A FZD2 FZD5 FZD7 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B2 HSD17B7 F13B HSD3B2 HSD17B4 CYP17A1 HSD17B1 HSD3B1 HSD17B3 CPN1 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260910%WP5193%HOMO SAPIENS Cholesterol synthesis disorders MSMO1 FDFT1 FDPS HMGCS1 MVD HMGCR EBP CYP51A1 SC5D DHCR24 DHCR7 LBR HSD3B2 SQLE IDI1 MVK GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260910%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis STAT4 HLA-DRB1 IL6ST TRAF1 IL2RA CTLA4 SLC22A4 FCRL3 PTPN22 MHC2TA CD40 ITGAV PADI4 CCR6 CD244 PHF19 BLK TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260910%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling TGIF1 SMAD2 NKX2-1 FOXG1 SHH TGIF2 NODAL FGF8 GLI3 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260910%WP5314%HOMO SAPIENS Lactate shuttle in glial cells CA4 HEL-S-281 SLC16A3 SLC1A2 SLC16A7 NUDT14 SLC2A3 HEL-76 SLC4A4 HEL-S-133P AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260910%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits TCF7L2 TCF7L1 TNC VCAM1 CXCR4 LEF1 VHL POSTN SRC CYTIP NOTCH1 VEGFA INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260910%WP5120%HOMO SAPIENS Inclusion body myositis MSTN BACE1 SIRT1 NFKB1 PSEN2 NFKB2 APP PSEN1 PSENEN METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260910%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALNT1 SGMS2 CERS3 SGPP1 KDSR B4GALT1 CERK SGMS1 B3GALT2 B3GALT1 SGPP2 SPHK2 GALNT1 SPHK1 SGPL1 UGT8 B4GALT2 UGCG GALNT16 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260910%WP4630%HOMO SAPIENS Measles virus infection EIF2S1 CD3D RELA IKBKB JAK3 PIK3CD STAT5B CHUK FOS NFKBIA TLR9 MAPK9 IFNB1 CD3G IFNA6 CD3E MAPK10 CDKN1B BBC3 CASP9 CCND3 CCND2 CASP3 HEL-S-72p APAF1 CCNE2 CCNE1 JUN IFNA13 BCL2 CD46 IFNA14 IFNA16 CDK6 IFNA17 IFNA10 CDK4 IFNA21 CDK2 TNFAIP3 CCND1 BAX CYCS CSNK2A1 CSNK2A3 CSNK2A2 IFNA5 ADAR IFNA4 IFNA8 CSNK2B NFKBIB HEL70 EIF3S3 IL1B MAPK8 CASP8 BAK1 TRADD FADD IRAK4 IL2RG NFKB1 NFKB2 TRAF6 IL2RA IL2RB EIF2AK1 EIF2AK4 IRAK1 IL12B MYD88 PIK3R2 PIK3R1 MAP3K7 JAK1 TNFSF6 TP73 STAT1 BAD IFNA1 STAT3 TYK2 TRAF3 IL6 IRF7 EIF2AK2 HSPA2 BCL2L1 IFNA2 HSPA1A IL2 IL1A IL12A TLR7 TLR4 IFIH1 TBK1 IFNAR2 STAT2 IKBKE CLEC4M MX1 LNIR CD209 IRF3 RCHY1 RAB9A FCGR2B IFNA7 IRF9 RAB9B IFNAR1 MAVS RIGI IKBKG OAS2 OAS3 PIK3R3 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260910%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA NR1i1 RXRA COPPER METABOLISM%WIKIPATHWAYS_20260910%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 ATP7A SLC11A2 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260910%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IRF3 GSDMD NFKBIE NLRX1 NFKB1 RELA REL IKBKB F3 IKBKG CGAS CHUK NFKBIA TBK1 IL1B IKBKE MITA FCGR2A NLRP3 IFNB1 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260910%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins FADD JUN MAPKAPK3 MAP3K1 ACTG1 PAK1 IL1A BCL2 PS1TP5BP1 CASP10 CYCS TNF NFX1 RB1 MAP3K7 SPTAN1 PRKDC CASP9 HEL-S-102 DFFB LMNB2 CASP6 DFFA TNFSF6 ARHGDIB MAP2K4 CASP3 ACTA1 MAPKAPK2 SMIM40 APAF1 LMNA RIPK2 MAPK8 CASP8 FAF1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway CYP3A4 PTPA CYP4A11 EHHADH UGT1A4 UGT1A3 CYP2C9 UGT1A9 RXRA PPARGC1A SULT2A1 ABCC3 ABCC2 ALAS1 FOXO1 DNAJC7 NR1I3 CYP2C19 UGT1A1 SP1 SULT1A1 NCOA1 ABCB1 CYP2B6 CYP2A6 NCOA6 SMC1A APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260910%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2L2 GSK3B ITGA6 BCL2L1 ITGB4 BCL2A1 BCL2L12 BCL2L13 BCL2L14 MCL1 GSK3A BCL2 BOK BCL2L10 BAX PTHLH MYC AKT3 BAK1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer TIGIT CCL2 GATA2 CSF2 NCR1 IFNG NCR3 CD226 PRF1 MYC MICA ADAM10 FCGR3A KLRK1 TNF FOXO1 NCR3LG1 CCL4 MICB CCL3 CD96 ADAM17 BMI1 CCL5 CCL1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260910%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGB1 HEL-S-62p TNF CXCL8 SELPLG VCAM1 SELP IL1A KNG1 ITGA4 IL6 C6 C7 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260910%WP4707%HOMO SAPIENS Aspirin and miRNAs MVD WNT1 NFKB1 PTGS2 PTGS1 NR1C1 VEGFA SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260910%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway SPTLC1 SGMS2 CERS3 SGPP1 CERS5 DEGS1 CERS6 KDSR CERK LASS1 CERS2 SGMS1 DEGS2 SGPP2 SPHK2 SPHK1 SGPL1 PLPP3 SPTLC2 PLPP2 UGT8 UGCG SMPD1 PLPP1 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260910%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A CDH2 HEL-S-162eP NRXN3 AP2A2 ARC SRC HDAC10 SLC32A1 CACNG8 SDCBP CACNG2 SLC12A5 GABRR3 GABRR1 MBD5 SLC6A13 ERBB4 SLC6A8 SLC7A11 CRTC1 FFAR1 GRIP1 DLGAP3 EFNB2 PICK1 GRIA2 GRM6 STIM1 SLC1A1 HOMER1 NRG1 PDIA2 PIG59 GRIA3 GRIA4 GLS2 GRIK5 GAD1 GRIK3 ABAT GRIK1 ORAI1 GRIK2 HDAC1 GRM2 GRM8 MAPK1 SUMO1 MAPK3 MAP2K1 CREBBP STAT1 STAT3 GNA11 GRIN2B DKFZp762B153 GRM3 SLC1A2 PLCB1 GABRB3 GABRB2 GABRB1 GABRE GABRQ GRIN1 GABRA2 GABRP PRKCA GABRA6 GABRA5 GABRA4 GABRA3 SLC6A11 GRIN3B GABRG3 GRIN3A GABRG1 FRMPD3 ADARB1 SH3GL2 SLC6A12 NETO2 PPP2CA CPEB3 NPTN C1QL3 C1QL2 NWD1 SNX27 DLG4 ATAD1 SYVN1 LHFPL4 CABIN1 SNX14 SLC1A3 AP2A1 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260910%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 BASH CD1D SLAMF7 ISG15 CD80 CD22 CD82 ZEB2 CD40LG CD19 SH2D1A PDCD1 MFGE8 TMSB10 SELL IL-21 MS4A1 PAX5 TBX21 CRP PTPRC CD79A TNFSF13 MAF BCL6 HEL-S-72p CXCR4 CXCL12 TNLG7A BTLA IL6 XBP1 IFITM1 IL10 HEL-S-62p CR2 CR1 ICOS CXCL13 IFIT2 C4A IL2 IL4 IFNG IL12A TLR7 CD69 CD40 TLR4 CCR7 CXCR5 IFNAR2 CCL19 CCL21 TNF FOXO1 BCR IRF4 SYK IRF8 ITGAX GPR183 EBI3 BACH2 AID FCRL5 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids CEPT1 CHKB PCYT1B PCYT2 CHKA SGPL1 PEMT CHPT1 PTDSS1 PISD PTDSS2 ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP1541%HOMO SAPIENS Energy metabolism MEF2D NR1C2 ATF2 CAMK2G UCP3 UCP2 PPP3CA EP300 MYBBP1A SIRT3 PPP3CC MED1 GABPA MEF2C SIRT1 NRF1 PPARG RXRA PPARGC1A NR1C1 TFAM GSK3B MAPK14 HDAC1 FOXO1 PRKAB2 PRKAA2 FOXO3A CAMK4 PRKAG1 PPARGC1B PRKAG2 PRKAB1 PRKAG3 NCOA1 TFB2M TFB1M PPRC1 ESRRA MEF2B PPP3R1 PRKAA1 PRMT1 PPP3R2 CREB1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260910%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan HEL-S-90n HAAO NADSYN1 KMO TDO2 KYNU AFMID NMNAT1 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260910%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders F7 F10 GPT ARG1 HEL-S-20 ASS1 ASL NAGS OTC GLS2 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260910%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKBIA NFKBIE REL NFKB1 RELA IKBKB IKBKG CHUK ATR SIGNALING%WIKIPATHWAYS_20260910%WP3875%HOMO SAPIENS ATR signaling RAD9B TOPBP1 CHEK1 HUS1 ATRIP RPA3 RPA1 RAD1 RAD9A ATR NEUROINFLAMMATION%WIKIPATHWAYS_20260910%WP4919%HOMO SAPIENS Neuroinflammation MAPK14 ASCC1 RELA JUN CHUK FOS NFKBIA NOS2 COX2 TLR4 COX1 MAPK8 MTOR T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260910%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling ZAP70 CSNK1A1 GSK3B ITK CALM1 DYRK2 NFATC2 PRKCA NFKB1 PPP3CA DYRK1A PLCG1 GSK3A IL2 CTLA4 PDCD1 NFKBIA PTEN PTPN6 CD8B CD8A FYN LCK DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260910%WP5195%HOMO SAPIENS Disorders in ketolysis ACAT2 BDH1 HMGCS1 OXCT1 ACAT1 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260910%WP4540%HOMO SAPIENS Hippo signaling regulation TCF7L2 CDH6 CDH19 TCF7L1 CDH2 CDH24 PDGFRA FGFR4 CDH16 FGFR3 FGFR2 FGFR1 CSF1R GNAI3 CDC42 CDH8 KDR MTOR SMAD2 ARHA KIT YAP1 RAC1 TEAD3 TEAD4 LATS1 FLT1 WWTR1 GNAL GNA11 PRKD3 NTRK1 TEAD2 NTRK2 PLCB3 PLCB4 EPHA2 GNAS PLCB1 PLCB2 IGF1R NGFR PRKCI PRKCH PRKCB PRKCE PRKCA PRKAB2 PRKAA2 FLT3 PRKCQ PRKAG1 PRKAG2 LATS2 PRKAB1 PRKAG3 FLT4 PRKCZ PRKAR1B PRKAR1A NF2 PRKACG CDH9 CDH4 LEF1 CDH10 EGFR CDH11 CDH12 INSR CDH15 PRKAA1 CDH17 CDH18 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260910%WP129%HOMO SAPIENS Matrix metalloproteinases MMP23B MMP17 MMP19 TCF20 MMP26 hEMMPRIN MMP2 TIMP1 MMP9 TIMP3 TIMP4 TNF MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 MMP7 MMP3 MMP10 MMP12 MMP11 MMP14 MMP16 MMP15 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260910%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy CAMK2A SCN8A KCNQ2 KCNQ3 CALM1 RAB1A ZNF547 TRAPPC3 GIGYF1 TRAPPC6B KCNQ5 BACE1 DAG1 STX1A FGF13 VAMP2 FGF12 SCN4B PRRT2 SCN2A PRKCE RAB11A SNAP25 AKAP5 NEDD4 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 DECR2 ALOX5AP CYP4F3 PTGR1 LTC4S DECR1 ABCC1 ALOX5 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis CYP11B2 AKR1C1 CYP3A4 AKR1C2 AKR1D1 AKR1C4 SRD5A2 HSD11B1 CYP21A2 HSD11B2 BENZENE METABOLISM%WIKIPATHWAYS_20260910%WP3891%HOMO SAPIENS Benzene metabolism NQO1 DHDH MPO EPHX1 CYP2E1 GSTM1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260910%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis COL1A1 TEAD2 SNAI2 PBX3 YAP1 TWIST1 THBS2 EDNRA TEAD3 TEAD4 GPC6 SPARC COL3A1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260910%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP1A2 CYP3A4 NR1C2 NR1H3 CYP7A1 NR1i1 CYP4A11 CYP26A1 CYP2C9 ABCD2 PPARG CYP8B1 ABCG5 NR1C1 NR1B3 CYP24A1 ABCC3 ABCC2 RARA RARB CYP2E1 ABCD3 NR1I3 NR1i2 NR1H4 ABCB11 ABCG1 CYP27B1 ABCB1 CYP2B6 ABCA1 ABCB4 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD17B2 SULT1A1 HSD3B2 SRD5A2 CYP11A1 CYP17A1 HSD3B1 HSD17B3 UGT1A1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP581%HOMO SAPIENS EPO receptor signaling GRB2 SOS1 IRS1 SHC1 PTPRC SOCS1 SRC MAPK1 STAT5B MAPK3 RAF1 MAP2K1 EPO PTPRU MAP2K2 STAT1 STAT3 CISH EPOR PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4224%HOMO SAPIENS Purine metabolism and related disorders AMPD1 PNP RRM2B ADSL APRT PAICS IMPDH1 HEL-S-70p ADSS AOX1 TPMT XDH MOCOS PFAS ADA DGUOK HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation MUC1 GATA2 CSF3 FOS ACVR1B ARHH CSF2 EPO KLF1 PIM1 TRAF3IP3 HMGN5 TRIM29 CBFA2T3 ZNF835 ABO MXI1 IKZF1 NFE2 IL3 RIOK3 FLI1 LYL1 IL5 CXCR4 CSF1 CD34 VAV1 IL6 NCKAP1L FOSB SPI1 NFATC2 IL1A MHC2TA NR1A2 TPO RUNX1 MYB HES6 LMO2 GATA1 ITGB3 ITGA2B GP9 NOTCH1 XB IL1B LEF1 KITLG TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260910%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK3 JAK1 STAT3 EGFR MAPK1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260910%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260910%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways CAMK2A ATF2 ATF1 CAMK2G ATP2A2 DGKZ ACTG1 GJA1 FOS PS1TP5BP1 GNB2 GNB1 GNB4 GNB3 CACNB3 SLC8A1 CRCP IGFBP1 RXFP2 RGS4 RGS5 RGS1 RGS6 IGFBP4 ACTA2 CNN2 GRK5 OXT OXTR GRK4 CALD1 MYL4 IGFBP6 PKIB PKIA PKIG RGS18 GNG3 RGS17 GNG2 RAMP2 GNG5 RAMP3 GNG4 RGS14 RGS16 GNG7 RGS20 GNG8 CORIN GUCA2B RGS11 ACKR5 CREB1 HEL-S-14 MAFF SFN ATF6B RAMP1 JUN YWHAG HEL-S-93 GNB5 SP1 ATF5 IL1B NFKB1 RGS2 HEL2 ATF3 MYL2 LPAR1 RYR1 CALCA YWHAQ HEL-S-1 PLCG1 HEL-S-21 CRH ETS2 ACTA1 ADCY1 ACKR3 ATF4 IL6 IGFBP2 RLN1 CALM1 RYR3 CREB3 ADCY3 ADCY6 ADCY5 GABPA DKFZp686L0365 IGFBP5 ADM ITPR2 PLCB3 ADCY8 ADCY9 GNAS GNG12 GNG11 GNG13 PRKCH RGS10 MYLK2 PRKCB PRKCE PRKCA GNGT1 PDE4D PRKCQ GABPB1 PRKD1 PDE4B PRKCZ PRKAR1B PLCG2 PRKAR1A RYR2 CAMK2D INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP453%HOMO SAPIENS Inflammatory response pathway CD80 IL2RG TNFRSF1A CD40LG THBS1 IL2RA IL2RB IL2 VTN IL4 IFNG CD40 LAMC2 LAMC1 ZAP70 COL1A1 COL1A2 LAMA5 IL5RA TNFRSF1B THBS3 IL5 COL3A1 LAMB2 LAMB1 LCK CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260910%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer CCNE1 PIK3CD PIK3C2G NRAS PIK3C2B HRAS CDK6 RAF1 CDK4 CDK2 CCND1 IGF1R ERBB2 AKT3 MTOR IRS1 PIK3R2 INS PIK3R1 CDKN1A CDKN1B MAPK1 PIK3R4 MAPK3 PIK3R3 PIK3R5 RPTOR EGFR GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260910%WP2261%HOMO SAPIENS Glioblastoma signaling DKFZp781B1423 PDGFRA CBL FGFR2 FGFR1 EP300 SRC PIK3CD PIK3C2G PIK3C2B MAP2K5 BRAF AKT3 PIK3R2 RB1 PIK3R1 CDKN1A FOXO3A CDKN1B MAPK1 PLCG1 MAPK3 CDKN2A CCND2 MAP2K4 MAP2K1 MAP2K2 ERBB3 GRB2 CCNE1 TSC1 MAP2K6 MAP2K3 TSC2 NRAS CDKN2B CDKN2C HRAS RAF1 CDK6 CDK4 CDK2 CCND1 MDM2 IGF1R ERBB2 ATM PRKCI SPRY2 PRKCH IRS1 PRKCB PRKCA FOXO1 ARAF PRKCQ PRKCZ PTEN PLCG2 BRCA2 EGFR PDPK1 MSH6 FOXO4 NF1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2876%HOMO SAPIENS Pregnane X receptor pathway ABCC3 ABCC2 CYP3A4 FOXO1 DNAJC7 CYP3A7 SLCO1B1 NR1i2 CYP4F12 SRC UGT1A4 CYP2C9 UGT1A3 UGT1A1 CYP2C19 UGT1A9 NCOA1 ABCB1 CYP2B6 CYP2A6 RXRA PPARGC1A SRPX2 SULT2A1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260910%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNC2 TNNT1 TNNT3 MYH8 HEL-S-108 TPM3 ACTG1 TNNI3 DMD TMOD1 ACTN4 MYL2 HEL113 MYH6 TTN TNNI1 TPM1 ACTA2 TCAP HEL-S-273 MYL4 MYL1 MYL3 TNNC1 ACTA1 DES ACTN2 MYOM1 TNNI2 MYBPC3 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP4784%HOMO SAPIENS Proteoglycan biosynthesis CHST3 PAPSS2 SLC35B2 CANT1 BPNT2 XYLT2 XYLT1 CHSY1 CSGALNACT1 SLC26A2 B3GAT3 CHST14 B3GALT6 EXT1 EXT2 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260910%WP5294%HOMO SAPIENS Sildenafil treatment HEL-S-162eP GSK3B ZNF746 PDE4D PARK2 PDE4B PDE4A GUCY1B1 PRKG1 NRF1 NOS2 PDE5A GUCY1A2 PPARGC1A AKT3 TFAM SICKLE CELL DISEASE%WIKIPATHWAYS_20260910%WP5604%HOMO SAPIENS Sickle cell disease TLR4 IL1B IL18 HBA2 HBB DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260910%WP2855%HOMO SAPIENS Dopaminergic neurogenesis TGFB1 EN1 PITX3 EN2 SLC6A3 LMX1A RET HEL-S-53e SLC18A2 MSX1 TH NEUROD1 NEUROG2 FGF8 NKX6-1 DDC ASCL1 SHH OTX2 NKX2-2 FOXA2 WNT1 LMX1B GBX2 STAT3 CDKN1C SOX2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260910%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 RIPK1 FADD TNFRSF1A NFKB1 MAPK10 MAP3K1 CASP9 AIFM1 CASP6 CASP2 TNFSF6 CASP3 APAF1 CYCS CASP8 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260910%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways ENO1 HEL-S-68p ALDOB HEL-S-162eP PDGFRA HEL-S-49 SHMT1 EP300 ME1 MAP2K5 KDR BHLHE41 HEL-S-32 MTOR CEP290 SSPN PSAT1 PGM2 PHGDH PSPH CREBBP RPTOR FLT1 STAT3 ENO2 ENO3 MLST8 PFKP VEGFA BAP1 HK3 KSR1 TSC1 PFKM KDM5C SETD2 EFCAB3 AKT1S1 PLOD2 ENPP3 TSC2 SQSTM1 PBRM1 RAPGEF5 SDSL PGBD5 HEL-S-87p LDHD KCNJ2 CAMK1 VHL PKLR HEL-S-281 GRB10 RHEB ACACA HIF1A FASN DEPTOR ACACB ACLY HEL-S-51e PTEN EGFR HEL-S-30 HK2 PFKL HEL-S-133P UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 ARG1 ASS1 ASL NAGS SLC25A13 OTC GLS2 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260910%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2 TMEPAI ATG16L1 TGFBR2 NEDD4 TGFBR1 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5380%HOMO SAPIENS 5q35 copy number variation UIMC1 FGFR4 DRD2 EIF4E1B ABRAXAS1 INPP5D BRCC3 SRC GNAI3 USH1C SNCA SLC34A1 MAPK9 EED MAPK10 PIK3R1 H2AX PLCG1 NTN1 RGS14 CXCR4 KDM6B GRB2 HK3 SOS1 GRIN2B FRS2 CYP7A1 COX6A1 GPRIN1 JUN GNAI1 COX6B1 TMED10 COX7A1 COX3 MAX COX2 PRR7 COX7B KIAA1191 FAF2 COX7C COX1 DDX41 IGF1R MYC TRIAP1 COX8A BABAM1 BABAM2 RNP24 ARL10 FBXW7 COX5A TMED9 ADAM10 BARD1 RNF44 UNC5A MYO7B GRIN1 ARFGAP2 HIC2 DOK3 CDHR2 PNPLA2 FAM193B PFN3 DBN1 LMAN2 CLTB RAB24 ZNF346 HEL-S-273 SNCB ABHD5 PRELID1 NELFB PTPRN2 NOP16 FGF19 MUPCDH HIGD2A CAPN3 TSPAN17 PTH PDLIM7 ANKS4B MXD3 MAGED1 H3F3B MAPK8 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome REC8 APC PTPA CDC2 SMC3 PPP2R1B PPP2R1A WAPAL PTTG1 PDS5B PDS5A AURKB RAD21 PPP2R5B PLK1 PPP2R5A PPP2R5D NIPBL STAG2 PPP2R5E PPP2R5C SMC1B HDAC8 ESPL1 PPP2CA CDCA5 SGOL1 STAG3 ESCO1 ESCO2 MAU2 SMC1A CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP3869%HOMO SAPIENS Cannabinoid receptor signaling CYP3A4 CYP2C9 FAAH DAGLA ADORA2A CYP1A1 MAPK9 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 MAPK1 CNR2 CYP2C19 MAPK3 PRKAR1B PRKAR1A PRKACG ADCY1 CNR1 NAPEPLD AHR DAGLB MAPK8 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation CDH2 SNAI1 AP2A2 ITGA6 SNAI2 CASK SLC17A6 SLC17A7 DLG2 SOX17 SHANK1 SLC18A3 UNC13A SYP TNC HNF4A ADRA2C HES3 HTR5A GATA6 ADRA2B ADRA2A ROBO1 CACNG2 TPM1 CSPG4 PECAM1 AQP4 GATA4 LHX1 SOX2 SLC6A5 ACHE PAX3 SLC6A2 SLC6A3 KLF4 CLDN11 DPPA3 MSX1 TH CNP MBP SOX9 FOXA2 MOG FOXD3 MSX2 OLIG2 SOX10 BMP4 LEF1 HES1 RIMS2 HOMER3 BSN HES5 RBFOX3 FBXO15 TBR1 TWIST2 FEV LIN7A FUT4 HOMER2 CD24 PCLO ERC1 DPPA2 ERAS TBXT GLRA1 HOMER1 GLRA2 TWIST1 GLRA3 GLRB RIMBP2 HTR1A POU5F1 NEF3 PIG59 ZFP42 MIXL1 NODAL KCNJ6 GLS SLC6A9 GAD1 GAD2 ChAT NLGN1 LMX1B TPH1 CD34 GRIN2B GFAP S100B SLC1A2 NEFL FGF4 NGFR GPHN GRIN1 ITGB1 SHANK3 GABBR2 GABBR1 MAP2 NOTCH1 ESRRB SNAP25 DLG4 SLC1A3 AP2A1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260910%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone CASR GRM3 GPRC5A GPRC5D GPRC5C GABBR2 GRM2 GABBR1 GRM8 GRM6 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260910%WP500%HOMO SAPIENS Glycogen synthesis and degradation HK3 PPP2R2C PPP2R2B PHKG2 CALM1 PTPA PPP2R1B PPP2R1A PYGB PYGM PYGL AGL PHKB PHKA1 PPP2R2A PPP2R3B GSK3B PPP2R5B PPP2R5A PPP2R5D GYS2 GYS1 PPP2R5E PPP2R5C GSK3A GYG1 PHKA2 PPP2CA PPP2R3A HK2 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260910%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HEL-S-162eP HEL-S-49 PPARG GPD1 HIF1A HMFN0839 CD36 HEL-S-133P PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260910%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection LY96 TUBA2 TUBA8 ROCK1 TUBA1C ROCK2 TUBA1B NCL ACTG1 CDC42 TUBA1A ARPC5 TUBAL3 PS1TP5BP1 TUBB EZR TUBB2A TLR4 ARPC1B ARPC4 HEL-68 TUBA3E KRT18 ARPC2 ARPC3 TUBB4B ARHGEF2 TUBB4A ITGB1 HEL-S-93 WAS PRKCA ARHA TLR5 CLDN1 TUBB8 YWHAQ TUBB6 TUBB1 NCK1 TUBA4A WASL NCK2 HCLS1 FYN CD14 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260910%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C9 COLEC11 HEL-S-62p C3AR1 FCN1 C5AR1 C8A C6 MASP2 ACE2 C7 CHOLESTASIS%WIKIPATHWAYS_20260910%WP5238%HOMO SAPIENS Cholestasis ABCC3 SLC22A1 ABCC2 SLCO1A2 EPHX1 NR1I3 SCARB1 NR1H4 ABCB11 HMGCR LDLR ATP8B1 RXRA ABCB4 ABCG8 ABCG5 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome DUSP14 CCL2 MED1 RPL23 CACNB1 DHRS11 TBC1D3B TBC1D3E TBC1D3C CWC25 TBC1D3I AATF IKZF3 CISD3 TBC1D3H CCL4 TCAP RDM1 CCL3 ARL5C C17orf50 GPR179 UNC45B MMP28 SLC35G3 SRCIN1 SLFN12 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 CCL14 ZNF830 CCL13 SLFN5 GGNBP2 CCL18 CCL15 CCL3L3 LHX1 FBXO47 MRM1 MLLT6 TCF2 FBXL20 NEUROD2 PGAP3 MIEN1 PPP1R1B ZNHIT3 PIGW C17orf78 CCT6B ASIC2 STARD3 RFFL CCL11 GAS2L2 SOCS7 CCL4L2 CCL16 HEATR9 TAF15 RASL10B PCGF2 SYNRG EPOP PEX12 PLXDC1 NLE1 ARHGAP23 HEL-S-6a TBC1D3K STAC2 CCL8 CDK12 SPMAP1 CCL7 ERBB2 FNDC8 GRB7 ACACA PNMT TEC TMEM132E PIP4K2B CCL5 CCL1 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis GPHN XDH MOCS2 MTARC2 SUOX MOCS1 AOX1 VOLTAGE GATED SODIUM CHANNEL ACTION POTENTIAL%WIKIPATHWAYS_20260910%WP5594%HOMO SAPIENS Voltage gated sodium channel action potential AKAP7 PRKCA EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260910%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HDAC1 HEL25 RB1 CBX3 RBBP7 H3C8 CHD4 HDAC2 KDM1A CHD3 SUV39H1 MTA3 H3C15 RBBP4 LEF1 MTA2 MBD3 H3F3B MBD2 CBX1 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260910%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 IRF3 TLR8 TLR7 MAVS TLR3 IFIH1 RIGI MR1 TNFRSF11A METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260910%WP5355%HOMO SAPIENS Metabolic epileptic disorders ENO1 HEL-S-68p ALDOB HEL-S-162eP FBP1 HEL-S-49 CTH SHMT1 AMT SLC25A5 PCK1 XDH HEL-S-32 SLC2A2 GLS2 GCK GLUD1 AADAT GOT2 DLAT PSAT1 SLC2A3 PHGDH HEL60 PSPH G6PC1 BTD PC HLCS CDO1 ENO2 ENO3 MPC2 PFKP FBP2 HK3 PFKM PGAM1 ECHS1 SFXN1 ACAT1 HEL-S-87p SLC25A15 DLD GLDC SLC2A4 MOCS2 PGAM2 MDH2 MOCS1 MOCS3 MPC1 AASS GPHN SLC7A2 PKLR HEL-S-281 SPCS1 GPT DHTKD1 ARG1 HEL-S-20 GCDH ASS1 ASL PDHA1 ALDH7A1 OTC HEL-S-51e CBS ETHE1 SQOR SUOX SLC25A1 HEL-S-30 HK2 PFKL HEL-S-133P SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260910%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway TMPRSS4 TLR7 SCARB1 CTSL TMPRSS2 FURIN NRP1 ACAT1 ACE2 SLC6A19 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260910%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds TNKS CSNK1A1 FZD8 SFRP4 GSK3B MBOAT1 APC DKK3 DVL2 TCF4 FZD1 WNT1 AXIN1 LEF1 FZD7 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy EIF2B5 TGFB1 PLA2G2A NFKB1 FGFR2 IKBKB ROCK1 ROCK2 PIK3CD MYLK3 CHUK MAP2K5 NRG1 FZD1 LRP5 WNT3A EDN1 MAP3K7IP1 MAP3K14 LRP6 MAPK7 MTOR MAPK4 GSK3B MAPK14 RCAN1 ARHA PIK3R2 PIK3R1 CDK7 MAPK1 RAC1 MYEF2 MAPK3 PRKG1 MAP2K4 MAP2K1 MAP2K2 NPPB GATA4 STAT3 IL6ST CALM1 MAP2K6 PPP3CA MAP2K3 RAF1 PLCB2 EGF IGF1R IKBKE CISH FGF2 PRKCB TNF DVL1 MYLK IKBKG HDAC5 HDAC7 LIF PIK3R3 NPPA IGF1 CTF1 NFATC4 CDK9 PDPK1 FZD2 CAMK2D MAPK8 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260910%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F2 PLG HEL-S-78p F13A1 F13B FGA IL26 SIGNALING%WIKIPATHWAYS_20260910%WP5347%HOMO SAPIENS IL26 signaling IL33 IL17A CCL20 IL20RA IL10 IL10RB CXCL8 RELA JUN DDIT3 CSF2 NFKBIA COX2 RORC BAX MAPK9 TNFSF11 MMP9 ATP6V0D2 SMAD2 MAPK14 TNF CTSK NFATC1 DCSTAMP ACTA2 SOCS3 MAPK1 MAPK3 JAK1 DEFB4B IL26 MPO CASP3 STAT1 STAT3 IL1B TYK2 MAPK8 IL6 EPHA3 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260910%WP692%HOMO SAPIENS Sulfation biotransformation reaction PAPSS2 SULT2B1 PAPSS1 SULT6B1 SULT1C4 SULT1E1 SULT1B1 HEL-75 SULT1A1 SULT1A4 SULT1A2 SULT1C3 SULT1C2 SULT2A1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260910%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 LEPTIN SIGNALING%WIKIPATHWAYS_20260910%WP2034%HOMO SAPIENS Leptin signaling RELA NFKB1 IKBKB ROCK1 ROCK2 SRC CDC42 STAT5B CHUK SH2B1 MTOR GSK3B MAPK14 SHC1 ARHA REL PIK3R2 PIK3R1 SOCS3 MAPK1 RAC1 PLCG1 MAPK3 JAK1 NCOA1 MAP2K1 MAP2K2 STAT1 BAD STAT3 PTPN11 CREB1 RPS6KB1 GRB2 SOS1 RPS6KA1 EIF4E SOCS7 LEP HRAS RAF1 ERBB2 CISH RPS6 IRS1 CFL2 ACACA SOCS2 FOXO1 EIF4EBP1 PTPN1 KPNA4 PRKAA2 PDE3B KHDRBS1 LEPR IKBKG GSK3A ACACB SP1 PTEN PLCG2 PRKAA1 MAPK8 FYN MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260910%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC25A11 SLC1A3 HEL-S-32 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260910%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis AKR1C2 STAR AKR1C4 HSD3B2 SRD5A2 CYP11A1 CYP17A1 HSD17B3 HSD17B6 POR REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260910%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling PDGFRA F2R IL2RG IL10RB JAK3 SRC IL2RA IL2RB SETD7 IL7R MAPK9 MAPK7 MTOR MAPK6 AGTR1 AGTR2 IL21R MAPK4 GHR MAPK14 IL11RA IFNGR1 MAPK12 CNTFR MAPK13 IL27RA MAPK10 PTPRC MAPK11 IL3RA SOCS3 MAPK1 IL6R IL22RA1 MAPK3 JAK1 CREBBP RPTOR TRIM28 STAT3 TYK2 MLST8 IL6ST IFNLR1 IL10RA IL20RA IL20RB MPL AKT1S1 MAPKAP1 IL9R IFNAR2 IFNGR2 IL15RA RICTOR PRKCB CSF2RA IFNAR1 PTPRT MAPK15 IL5RA DEPTOR OSMR CSF2RB F2RL2 CTF1 DUSP2 EGFR F2RL3 MAPK8 CSF3R OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260910%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IL33 CCL20 TSLP EPO IL11 IL15 IFNB1 IL3 IL7 IFNA6 CXCL16 IL36A IL36B IL36G IL1F10 IL20 IL26 IL27 PF4V1 CCL14 CCL13 CCL18 CCL15 CCL27 CCL25 CCL26 CCL24 IL31 IL37 IL19 CCL4L2 IL36RN IFNA13 CXCL6 IFNA14 CXCL3 IFNA16 CXCL5 IFNA17 IFNA10 XCL2 IL25 XCL1 IFNA21 CCL8 CCL7 AREG CNTF IFNA5 IFNA4 CXCL1 IFNA8 TNF CXCL2 LIF CTF1 IL1B CCL5 TGFB1 NFKB1 PF4 CCL2 CSF3 CSF2 IL12B IL22 IL-21 IL13 opn MMP9 IL23A CCL28 LTA CCL4 CCL3 TNFSF13 IL5 MMP3 CXCL9 CXCL12 IFNA1 CSF1 IL24 TNLG7A CXCL14 CCL3L3 IL6 IFNL2 VEGFA IFNL1 IL17F IFNL3 IL17A IFNW1 IL10 CXCL8 CCL11 IFNA2 CXCL17 CXCL13 IL18 CCL17 CCL16 IL2 CCL22 PPBP IL4 CCL23 IL1A IFNG IL12A CX3CL1 CCL19 CCL21 CXCL11 IL9 IFNK IFNA7 OSM IL17D IL17C IL1RN EBI3 IL17B CCL1 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260910%WP3878%HOMO SAPIENS ATM signaling in development and disease MDC1 TP53BP1 ATF2 NFKB1 PPP5C PPM1D MRE11A RBBP8 TSC2 RIF1 RAD50 NHEJ1 CDK5 CDK2 ATM MTOR ATR AURKB HMGN1 MAPK14 RNF168 MAPK12 MAPK13 RNF8 MAPK11 IKBKG RNF20 ATMIN PRKDC KAT5 CEP63 HEL-S-102 LMNB2 PPP2CA CHEK2 CHEK1 TRIM28 NBN SMC1A STK11 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260910%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRG RARA RARB RXRA RXRB NR1B3 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260910%WP5172%HOMO SAPIENS Iron metabolism disorders STEAP3 FTL PANK2 CP CYBRD1 HEPH TFR2 FTH1 TF TFRC HAMP HFE SLC40A1 UQCRFS1 SLC11A2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260910%WP408%HOMO SAPIENS Oxidative stress response NOX4 NFKB1 GPX1 TXN2 GPX3 GSTT2 UGT1A3 FOS HEL-75 NQO1 GCLC CYP1A1 XDH MAPK14 MAPK10 MAOA MGST1 HMOX1 JUNB TXNRD2 CYBB SP1 NOX3 NOX5 NFE2L2 HEL-S-44 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260910%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling RELA TSLP NFKB1 NFKB2 SRC STAT5B GAB2 NFKBIA FES IL7R MAPK9 RPS6 STAT4 MAPK14 EIF4EBP1 TEC CRLF2 MAPK1 LYN MAPK3 JAK1 BTK MAP2K1 MAP2K2 RELB STAT1 YES1 STAT3 PTPN11 MAPK8 FYN LCK DRAVET SYNDROME%WIKIPATHWAYS_20260910%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A SNTA1 SCN8A HCN1 CALM1 NFKB1 MAPKAP1 SCN3B SCN3A SCN1B SCN1A FGF13 SCN4B MTOR SCN2B RICTOR SCN2A TNF PRKCA MAPK11 PRR5 CHD2 KCNA2 PCDH19 STXBP1 MLST8 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL17F TGFB1 IL17A CCL20 IL10 CXCL8 CCL2 IL2 IL4 CSF2 IFNG CXCL5 IL12A IL25 IL12B IL13 VEGFC LGALS9 MMP9 CXCL1 TNF IL23A CCL28 IL5 VEGFB REG4 VEGFD IL17D CXCL12 IL1B IL17C CCL5 IL17B IL6 VEGFA PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260910%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 TRADD RIPK1 FADD TNF TNFRSF1A TRAF2 CASP9 CASP3 BAX CYCS CASP8 BIRC3 RIPK3 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260910%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair MDC1 TP53BP1 RNF168 RNF8 SETD2 SUPT16H PRKDC H4C9 HIST1H4L XRCC5 SSRP1 RAD51 H1-1 NASP NBN ATM AUTOPHAGY%WIKIPATHWAYS_20260910%WP4923%HOMO SAPIENS Autophagy ATG101 ATG3 RB1CC1 ATG12 AKT1S1 WIPI2 DKFZp762B153 AMBRA1 UVRAG ATG16L1 MTOR PRKAB2 PRKAA2 PRKAG1 PRKAG2 DEPTOR PRKAB1 PIK3R4 PRKAG3 ATG9A ATG14 RPTOR ULK1 MLST8 PRKAA1 DKFZp686F0183 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260910%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway HSD17B2 SLCO4A1 SLCO1A2 NR3A2 SLCO2B1 SLCO1B1 HSD17B1 SLCO4C1 HSD3B1 SULT1E1 HSD17B3 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260910%WP545%HOMO SAPIENS Complement activation C9 CD55 C8G HEL-S-62p CFP C1QC C8A C4A MASP2 MASP1 CFB CFD C1QB C1QA C1S C4B_2 C6 C7 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260910%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPE RPIA PRPS1L1 HEL-S-304 DERA SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260910%WP4658%HOMO SAPIENS Small cell lung cancer ITGA6 TRAF1 COL4A2 COL4A1 RELA NFKB1 IKBKB COL4A4 COL4A6 TRAF6 TRAF2 PIK3CD CHUK RXRB NFKBIA RXRG NOS2 AKT3 LAMC2 LAMC1 RARB PIK3R2 RB1 PIK3R1 TRAF5 CDKN1A LAMA5 CDKN1B LAMA1 LAMA4 LAMA3 CASP9 COL4A3 COL4A5 CASP3 APAF1 LAMB3 TRAF3 LAMB2 CDKN1C LAMB1 DDB2 CCNE2 CCNE1 FHIT BCL2L1 GADD45B GADD45A PTGS2 CDKN2B GADD45G BCL2 CDK6 MAX CDK4 CDK2 CCND1 RXRA BAX MYC TRAF4 CYCS BIRC7 BIRC2 SKP1 BIRC3 ITGB1 ITGA2B CKS1B NFKBIB IKBKG LAMB4 PIK3R3 PTEN ITGAV POLK CKS2 E2F2 ITGA2 E2F3 CASP8 BAK1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 IL3 SIGNALING%WIKIPATHWAYS_20260910%WP286%HOMO SAPIENS IL3 signaling GRB2 RAPGEF1 SOS1 TGFB1 BCL2L1 CBL CXCL8 INPP5D SRC JUN PIK3CD STAT5B ENPP3 GAB2 HRAS FOS BCL2 RAF1 PTPN6 CD69 CCR3 IL3 SHC1 PIK3R2 PIK3R1 IL3RA YWHAQ HEL-S-1 MAPK1 IL5RA CSF2RB LYN MAPK3 SYK JAK1 MAP2K1 BAD CRKL STAT3 PTPN11 VAV1 MAPK8 FYN PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling CCNE1 PDGFRA ATF2 BCL2L1 TNFRSF1A MAP2K6 MAP2K3 TRAF6 JUN TRAF2 IL2 FOS BCL2 IFNG CCND1 BAX FGF7 MMP2 MAPK14 TNFSF10 MAPK12 TNF MAPK13 MAPK11 RB1 MCL1 TRAF5 CDKN1A BCL2L11 CCNA2 MAP3K5 JUNB CDKN2A TNFSF6 MAP2K4 NFE2L2 EGFR BMF HBEGF MAPK8 BAK1 IL6 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260910%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer CCNE1 SNAI1 SNAI2 RELA NFKB1 TGFBR2 TGFBR3 NFKB2 SRC CTGF CDK2 EGF HGF KDR AKT3 MMP2 MMP9 COL1A1 SMAD2 COL1A2 PLXNA2 REL CDKN1B MAPK1 RAC1 PECAM1 GSK3A PLXNA1 TGFBR1 MAPK3 CHD2 MAP2K1 SEMA3A MAP2K2 FLT1 RELB EGFR SMAD4 PLXNA4 NRP1 VEGFA CCNE2 PEPTIDE GPCRS%WIKIPATHWAYS_20260910%WP24%HOMO SAPIENS Peptide GPCRs GHSR TAC4 NPY1R BDKRB2 GNRHR CCR3 CCR2 FPR2 NPY5R AGTR1 AGTR2 AVPR2 OPRM1 SSTR3 SSTR4 SSTR5 MC3R OXTR NPY4R GRPR EDNRA EDNRB FPRL2 TACR1 TRHR FPR1 MC4R TACR3 CXCR4 IL8RB CXCR6 MC2R GALR3 GALR2 LHCGR GALR1 FSHR NTSR1 CCR10 NTSR2 CCR1 C3AR1 HCRTR2 HCRTR1 NMBR MC1R BRS3 CCKAR NPY2R CCR7 CXCR5 C5AR1 CCR5 CCR4 OPRK1 AVPR1B TSHR AVPR1A CCKBR BDKRB1 OPRD1 CXCR1 CXCR3 CCR8 CCR6 SSTR2 MC5R CX3CR1 ATP8A1 TACR2 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260910%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 H3Y1 TRIM63 H3Y2 DUX4 NR3A2 MYF5 CDKN1A EP300 RET FBXO32 MYOD1 ADRB2 PAX7 MYC PPARGC1A MYOG VEGFA CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260910%WP5603%HOMO SAPIENS Caffeine in myocytes TNNC2 TNNT1 TNNT3 MYH8 HEL-S-108 MYH13 MYH1 RYR3 MYH4 TPM3 MYH7 ACTG1 TNNI3 PS1TP5BP1 MYL6 MYL2 RYR1 MYH6 TNNI1 TPM1 ACTA2 HEL-S-273 MYL1 ACTG2 MYL3 MYL11 TNNC1 ACTA1 MYH2 RYR2 TNNI2 MEVALONATE PATHWAY%WIKIPATHWAYS_20260910%WP3963%HOMO SAPIENS Mevalonate pathway MVD HMGCR ACAT2 FDPS HMGCS1 MVK CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260910%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways FADS1 NR1H3 ELOVL4 ELOVL2 SOAT2 MVD HMGCR EBP SC5D CYP51A1 DHCR24 DHCR7 LBR SOAT1 SCD CYP46A1 SQLE IDI1 MVK MSMO1 SREBF2 HSD17B7 ACAT2 TM7SF2 FDFT1 CYP27A1 MYLIP FDPS ELOVL5 HMGCS1 GGPS1 NR1H2 FASN ELOVL3 ACSL3 FACL4 CH25H ABCG1 ABCA1 FADS2 ACSL1 TP53 NETWORK%WIKIPATHWAYS_20260910%WP1742%HOMO SAPIENS TP53 network TNFSF10 PMAIP1 CDKN1A GADD45A OTX2 BBC3 SUMO1 CDKN2A BCL2 BOK TP73 MDM2 BAX MYC TP63 ATM AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260910%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TCIRG1 NFKB1 IKBKB CLCN7 OSTM1 TRAF6 RAB7A SNX10 PLEKHM1 TNFSF11 TNFRSF11A RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260910%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 AGTR1 AGTR2 CYP3A4 TNF NFKB1 ARHA BDKRB1 NR1i1 ROCK1 MAPK1 BDKRB2 SERPING1 KLK1 KLKB1 CPN1 IL1A PRKG1 KNG1 IL1B REN ACE2 CYP24A1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260910%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 SLC25A20 BDH1 OXCT1 UCP2 ACAT1 HINT1 PATHWAY%WIKIPATHWAYS_20260910%WP5523%HOMO SAPIENS HINT1 pathway GTF2H3 GTF2H4 SH3RF1 GTF2H5 NFATC2 NFKB1 CDK7 JUN KARS1 CCNH USF2 HINT1 RUVBL2 FOS RUVBL1 ERCC2 MNAT1 TCF4 GTF2H2C_2 MAPK9 GTF2H2 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway GRB2 SOS1 MAP3K2 ATF2 CBL CRK RPS6KA1 SHC3 INPP5D SRC PXN NRAS GAB2 HSPB2 HRAS BCL2 BCLAF1 MEF2C RAF1 BRAF AKT3 MAPK14 SHC1 SHC4 SHC2 DOK1 MAPK11 PIK3R1 ARAF BCR MAPK1 HEL-S-102 MAPK3 BCL9 EIF4B CRKL VAV1 SPAG1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260910%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells POMC PRKCB GPR143 MC1R PMEL DKFZp686L0365 ASIP TYR PLCB3 TYRP1 PLCB4 DCT GNA15 ADCY9 PRKACG GNAS PLCB1 PLCB2 CREB1 VEGFA IRINOTECAN PATHWAY%WIKIPATHWAYS_20260910%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 CYP3A4 UGT1A10 BCHE ABCG2 CES1 SLCO1B1 CES2 UGT1A1 UGT1A9 ABCC1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260910%WP4830%HOMO SAPIENS GDNF RET signaling axis RET SOX17 GATA3 GLI3 SALL1 SIX2 AGTR2 GREM1 SPRY1 ROBO1 PAX2 IFT27 ALDH1A2 ROBO2 IFT25 HOXD11 HOXA11 SLIT2 HOXC11 EYA1 BMP4 GDNF SOX11 WT1 LHX1 FOXC2 FAT4 FOXC1 TCF2 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260910%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease HEL25 NOTCH3 HSPB2 MEF2C MYOD1 LBR DMPK ACTA1 DES HP1BP3 H2AZ1 HSPB3 LMNA MYOG CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment TGFB1 HLA-DRB1 CD80 CSF2RA IFITM2 CSF1R LAG3 CCL2 CTLA4 CXCR3 CSF2 TNFSF6 ITGB6 CXCR4 CCR2 CXCL12 CSF1 BAG3 CCL5 CCR5 KDR NRP1 VEGFA ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260910%WP554%HOMO SAPIENS ACE inhibitor pathway AGTR1 MAS1 AGTR2 TGFB1 BDKRB1 NR3C2 BDKRB2 CTSG CMA1 CYP11B2 ATP6AP2 KNG1 REN ACE2 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5407%HOMO SAPIENS 15q11q13 copy number variation RELA TJP1 GJA1 STX1B SPEF1 SMC5 SMC6 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K SIN3A GOLGA8J GJD3 MYZAP NECAB3 HDAC1 ANKRD2 LYPD6 ENTREP2 GJC2 UBN1 APP MLSN2 SLF2 CGN CXADR CREBBP TJP3 CDC42BPB FANCD2 CANX CALM1 STX1A GOLGA8R MTMR10 KLF13 CHRNA7 OTUD7A GOLGA8O GOLGA8Q TRPM1 KAT2B STXBP1 CCL5 GOLGA8H FAN1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260910%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H3-4 TERF2IP H2BC9 H2BC21 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L H2AX HIST1H2AB TPP1 H2AC6 ACD H2BC17 TERF1 H2BC12 H4C9 H2BC13 H2AJ HIST1H4L H2BC14 H2BC15 H2BC11 HIST1H2BE H2AZ1 H2AZ2 H2BC8 TERF2 H2BC3 H2BC1 H2AC20 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5400%HOMO SAPIENS 6q16 copy number variation GHSR POMC INS NTRK2 LEPR LEP GHRL SIM1 BDNF MC4R NPY INSR AgRP MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies HEL-S-171mP BTK S1PR4 ITGB1 ITGA4 S1PR1 S1PR3 MS4A1 S1PR5 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260910%WP247%HOMO SAPIENS Small ligand GPCRs TBXA2R PTGER1 PTGDR PTGIR PTGER3 CNR2 MTNR1A S1PR4 MTNR1B GPR50 PTGER4 PTGER2 LPAR1 CNR1 S1PR1 PTGFR S1PR3 S1PR2 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases GLA NPC1 SCARB2 LIPA HEXA HEL-S-111 GM2A PSAP NEU1 NPC2 NEU2 NEU3 NEU4 GLB1 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260910%WP288%HOMO SAPIENS Nod like receptor NLR signaling CD40 RELA IKBKB IKBKG EPHB2 MAPK8 MAP3K7 CHUK ERBIN EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260910%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways SELENOP FZD9 SMAD9 FZD8 PDGFRA FGF18 FGFR4 FGFR3 FGFR2 BMPR1A FGF10 FGFR1 WNT2B BMPR2 PIK3CD FOS DKFZp781O1323 FGF14 WNT9B MAP2K5 WNT16 LRP5 BRAF FGF13 FGF12 MAPK7 MAPK6 MAPK4 WNT7B HNF1A MAPK12 ACTR2 MAP2K6 MAP2K3 JUN RAF1 MDM2 EGF FGF2 DVL1 DVL2 FGF20 DVL3 FGF23 FGF22 FGF17 FGF16 LIF FGF19 PTEN BMP4 AXIN1 EGFR APC NOG ERAS SMAD6 FZD1 FZD3 WNT3A WNT7A WNT3 LRP6 AKT3 MTOR GSK3B PDGFA PIK3R2 MAPK1 JAK1 MAP2K1 MAP2K2 STAT3 PTPN11 ACVR1 GRB2 SOS1 IL6ST HRAS FGF3 FGF4 FGF6 FGF7 FGF21 FGF8 FGF9 ACVR2B WNT5B ARAF WNT1 WNT4 WNT10B SMAD1 WNT10A SMAD4 FZD2 FZD5 FZD4 FZD7 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260910%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport HEL-S-70p SHMT1 MTHFS SLC46A1 TYMS MTR FTCD DHFR HEL-S-51e SLC19A1 MTHFD1 MTHFD2 MTHFD2L FOLR1 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260910%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF LYRM4 ABCB7 FDX1 HSCB FDXR NFU1 FXN NUBP1 NUBP2 ISCU CIAO2B APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260910%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis IRAK1 TLR4 SPI1 APOE RELA NFKB2 TRAF6 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260910%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta COLGALT1 IFITM5 CRTAP P3H2 P3H1 TNFRSF11B PLOD2 SP7 FZD1 LRP5 LRP6 PLOD1 TNFSF11 COL1A1 PPIB COL1A2 ADAMTS2 BMP1 P4HA1 P4HA2 MBTPS1 MBTPS2 WNT1 MIA3 TNFRSF11A TMEM38B REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260910%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition BUB1B SMC3 APC CDC20 RAD21 MAD2L1 PTTG1 STAG1 CENPE SMC1A MAD1L1 ESPL1 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias ZFYVE9 SMAD9 TGIF1 TGFB1 LEFTY1 FST NOG FOXH1 NFKB1 TGFBR2 TGFBR3 ZEB2 ENG EP300 LTBP1 THBS1 ZNF423 LEFTY2 INHBA SMAD6 FOS FKBP1A DKFZp781O1323 SKI BAMBI MAPK9 opn SMAD2 FBN1 RUNX3 SKIL TGFBR1 MAPK3 JAK1 CREBBP STAT1 STAT3 ADAMTSL2 pp6425 JUN HRAS IFNG EGF TNF RUNX2 LIF WNT1 ITGB6 BMP4 SMAD1 LEF1 SMAD4 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260910%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming POU5F1 EGR1 TRIM71 MYC KLF4 SOX2 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260910%WP5050%HOMO SAPIENS TCA cycle in senescence ME1 PDP2 BRAF ME2 PDHA1 FH HEL-S-32 SLC25A46 PATHWAY%WIKIPATHWAYS_20260910%WP5521%HOMO SAPIENS SLC25A46 pathway MFN1 MFN2 APOOL MICOS13 MMGT1 IMMT TMEM85 OPA1 COX4NB MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 EMC6 EMC7 EMC10 IL1 SIGNALING%WIKIPATHWAYS_20260910%WP195%HOMO SAPIENS IL1 signaling MAP3K2 ATF2 IRAK4 IRAK3 RELA NFKB1 PELI1 IKBKB MAP2K6 MAP2K3 TRAF6 JUN MAP3K1 IL1R1 CHUK SQSTM1 HSPB2 IL1A NFKBIA HEL-S-71 ECSIT IRAK1 IRAK2 MAP3K7IP1 TAB3 MAP3K14 MAPK9 MYD88 MAPK14 REL PIK3R2 PIK3R1 NFKBIB IKBKG MAPK1 UBE2V1 PLCG1 MAP3K7 MAPK3 PRKCZ MAP2K4 MAP2K1 MAP2K2 MAPKAPK2 IL1B PTPN11 MAPK8 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260910%WP4217%HOMO SAPIENS Ebola virus infection in host ITGA6 EIF2S1 CLTCL1 RELA FLNA EP300 RASA2 PIK3CD ACTG1 CDC42 PAK1 C1QBP PS1TP5BP1 VPS4A AXL ACTN1 CAV3 CAV2 ACTN4 HLA-DRB1 VPS18 TFAP2A VPS16 NPC2 RFC1 VPS39 HLA-DQA2 HLA-DQA1 NPC1 VPS33A BST2 CLEC10A ICAM2 VPS41 ICAM3 IGF1R KPNA1 CD300A TIMD4 SCIN CLEC6A ASGR1 HAVCR1 HLA-DQB2 DAB2IP TYRO3 CLTB MERTK FOLR1 EGFR NEDD4 MBL2 NFKB1 NFKB2 MFGE8 RAB5A HLA-DMA TSG101 REL ARHA PIK3R2 PIK3R1 SOCS3 CTSL MAPK1 RAC1 MAPK3 RHOB CREBBP RELB STAT1 IRF7 EIF2AK2 FLNB HAVCR2 HLA-DOA HLA-DOB IL4 HLA-DPA1 HLA-B HLA-C HLA-A HLA-F TLR4 HLA-G HLA-E TBK1 HLA-DQB1 HLA-DMB HLA-DRB5 IKBKE CLEC4M IQGAP1 CD209 IRF3 HLA-DPB1 RAB9A ITGB1 ITGB3 TIAM1 RIGI RAB7A PIK3R3 ADAM17 ITGAV CLTC ITGA4 CLTA ITGA2 ITGA1 VAV2 ADIPOGENESIS%WIKIPATHWAYS_20260910%WP236%HOMO SAPIENS Adipogenesis MEF2D CEBPA STAT5B PNPLA3 PCK1 RETN ASIP PPARG HNF1A RARA CNTFR RB1 CDKN1A GATA4 WWTR1 FRZB GDF10 CREB1 FOXC2 MBNL1 GADD45B GADD45A NDN DDIT3 RBL2 CFD SLC2A4 PRLR SFRP4 IRS1 GTF3A TNF ADFP FOXO1 SPOCK1 DVL1 INS KLF7 HIF1A SP1 LIF IGF1 BMP4 BMP2 CISD1 LMNA ZMPSTE24 BMP3 TGFB1 SOCS1 EGR2 KLF5 CEBPD LPIN1 CYP26A1 LPIN2 GATA3 TWIST1 GATA2 KLF15 TRIB3 MEF2C RXRG FZD1 LPL ID3 SCD RORA MIXL1 NR1C1 CYP26B1 CEBPB BMP1 SOCS3 NCOR1 PCK2 RBL1 NCOA1 E2F4 NCOR2 MEF2B STAT1 STAT3 AHR IL6 IL6ST NR1C2 NR1H3 BSCL2 LPIN3 LEP NAMPT PLIN1 PTGIS UCP1 HMGA1 RXRA PPARGC1A KLF6 STAT2 GH1 WNT5B IRS4 LIPE CELF1 WNT1 NR3C1 OSM WNT10B NR2F1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260910%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 FST NFKB1 ATL1-beta BMPR1A EGR2 GATA3 FOS CTGF GPRC5D FZD1 CD133 WIF1 DSC2 NFATC1 SFRP1 RUNX3 S100A4 ZBTB16 PERP DKK4 KLK6 ELANE CD34 SOX2 FOSB KRTAP8-1 BMP6 FOXQ1 JUN DKK1 MSX1 IFNG IGFBP5 CD200 GTPBP4 RBPJ GJB6 CASP14 DKK3 SOSTDC1 FOXE1 HR Nbla10317 SOX9 GAS1 HOXC12 NOTCH2 KRTAP3-3 PHLDA1 NOTCH1 KRTAP15-1 SPINK6 SPINK5 MSX2 ADAMTS20 ADAM17 DSG1 DSG4 TCF4 GPR49 IGF1 NR3C1 DLX3 KLK5 TCF3 KLK4 BMP4 LRIG1 SMAD1 LEF1 KRTAP6-1 TP63 EGFR KRTAP2-4 SMAD4 GSDMA KITLG KLK13 KLK14 FOXN1 KRT19 KETOGENIC DIET IN EPILEPTOGENESIS%WIKIPATHWAYS_20260910%WP5639%HOMO SAPIENS Ketogenic diet in epileptogenesis ABCC8 GAD1 KCNA1 HCAR2 GLUD1 HDAC1 SIRT4 SLC25A14 SLC25A27 HMGCS1 UCP2 HDAC8 HDAC2 HDAC3 NRG1 TXNIP PPARG NFE2L2 AKT3 ERBB4 NLRP3 RPS6 HEL-S-133P TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260910%WP2113%HOMO SAPIENS Type III interferon signaling IFNL1 JAK1 IFNL3 IFNLR1 IRF9 IL10RB STAT1 TYK2 STAT2 IFNL2 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260910%WP2007%HOMO SAPIENS Iron metabolism in placenta STEAP3 IREB2 TFR2 TF HEPHL1 TFRC MCOLN1 HAMP SLC40A1 HEL60 SLC11A2 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260910%WP3947%HOMO SAPIENS Serotonin and anxiety FMR1 PLEK PLCD4 POMC PRKCB ADRA1A ARC EEF2K PPP3CA CRH FOS HTR1A TRPV1 HTR2A NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260910%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum SLX4 XPA SLX4IP XPC POLD3 POLD4 POLD2 XAB2 GTF2H2C_2 RPA1 GTF2H2 GTF2H3 HMGN1 GTF2H4 UVSSA GTF2H5 POLE4 CUL4A CDK7 POLE2 H2AC6 CHD1L RPA3 CCNH ERCC1 H4C9 POLE3 PCNA CETN2 ERCC2 HIST1H4L MNAT1 POLE CUL4B POLK RFC3 RFC4 LIG1 RFC2 GPS1 H3F3B RFC1 RBX1 RAD18 DDB2 DDB1 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis FADS1 PLA2G5 PLA2G6 ELOVL2 ELOVL5 PLA2G4B ACOX1 ACSL3 ACOX3 FACL4 FADS2 ACSL1 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260910%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHGEF2 IRF6 ARHA ARHGAP29 TP63 TFAP2A NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260910%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAMK2A ISG15 TNFRSF1A NFKB1 IFI27L2 IKBKB CAMK2G NR1i1 RSAD2 NFKB2 CD40LG CCL2 MED1 RXRB RXRG NOD2 MAPK9 MAPK7 MAPK14 IFNGR1 MAPK12 MAPK13 MAPK11 MAPK1 MAPK3 JAK1 RELB STAT1 TYK2 IL6 CXCL8 IFNA2 JUN NRAS SP3 HRAS IFNG TLR8 PLCB3 PLCB4 CD40 TLR4 PLCB1 RXRA PLCB2 IFNAR2 STAT2 IFNGR2 CYP24A1 PRKCH PRKCB TNF PRKCE PRKCA PRKCQ CAMP OAS2 SP1 DEFB4B PRKCZ CYP27B1 PLCG2 PLCE1 CAMK2D MAPK8 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260910%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL BDH1 OXCT1 ACAT1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260910%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHC SDHAF1 SDHD SDHAF4 SDHA SDHB SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260910%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN SIRT1 FOXO1 IGF1R MTOR VITAMIN D METABOLISM%WIKIPATHWAYS_20260910%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27B1 CYP2R1 PTH DHCR7 CYP27A1 NR1i1 RXRA GC RXRB CYP24A1 CYTOSINE METHYLATION%WIKIPATHWAYS_20260910%WP3585%HOMO SAPIENS Cytosine methylation TET2 TET1 MBD3 TDG HEL-S-26 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260910%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1A ADRA1B ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias TGFB1 FGF18 FGFR3 BMPR1A FGFR1 STAT5B GLI3 ADAMTS4 NKX3-2 CST5 MEF2C MGP IGF2 opn MMP9 GHR HMGCS1 RUNX3 ENPP1 THRA BMP7 FRZB STAT1 ACAN CDKN1C VEGFA COL10A1 CALM1 BMP6 ALPL DDR2 IHH COL2A1 IGF1R ADAMTS5 SCIN GH1 PTH1R KIF3A FGF2 TIMP3 RUNX2 SOX9 SOX6 SOX5 PLAT CAB39 PTH IGF1 CHST11 PTHLH PTCH1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NKX6-1 PTF1A RBPJL PDX1 FGF10 KAT2B PROX1 RBPJ HES1 NOTCH1 IL17 SIGNALING%WIKIPATHWAYS_20260910%WP2112%HOMO SAPIENS IL17 signaling IL17F IL17A IL17RC RELA NFKB1 IKBKB TRAF6 CEBPD IL25 MAP3K14 TRAF3IP2 GSK3B CEBPB IL17RA NFKBIB IKBKG MAPK1 MAP3K7 SP1 MAPK3 JAK1 IL17RB IL17D STAT3 IL17C TRAF3 IL17B MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260910%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes TRIP13 TXN2 C1QBP SRSF10 TDG GPAM POLD2 USP1 AXL CACNA2D1 MAPK7 MAPK14 MAPK12 POLE4 RB1 NFIA PLXND1 MCL1 CDKN1A CDKN1B UBE2J1 LMNB2 CUL4B EZH2 TMEM41B BACH1 CDKN1C SMC1A CPNE8 CHORDC1 VEZT RAVER2 PWP1 SEC62 PNP VPS39 DHX57 CDK5RAP3 CIAO2A MBNL1 CARHSP1 WDR82 POGLUT3 GOLGA7 FAR1 RARS1 ATP6V0E1 HACD3 GRPEL2 PRIM1 TPM3 FNDC3B SNX6 FNDC3A RAB27B NCEH1 NCL SFXN1 RAI14 TNFRSF10B GFM1 SRSF9 POM121 ASH2L PTPRF TMED10 COIL CBFB MRPL20 POLA2 SERP1 COMMD9 TMED3 CDK6 ATP6V1C1 GNPNAT1 CTSC ATP6V1F MRPS24 SLC4A10 TMT1A TBCA PEDS1-UBE2V1 AP3B1 MOV10 SLC7A6 CDCP1 CHMP2A SRPRB ANP32B FRG1 SSNA1 DKFZp761E1322 RNP24 AMIGO2 PICALM ARF4 NAPG TRAM1 PGRMC1 SHOC2 ADAR MAGT1 PPIB MRC2 SPRYD4 IRS1 SPTLC1 TTC9C SH3BGRL3 ARHG GNA13 TMED7 WDR11 ELOVL5 TPPP3 PRPF40A SNX15 LAMTOR3 CSDE1 TUSC2 PXDN LTN1 MTRR PTMA ARID4B HEL-S-273 SEC23A MRPS33 ABHD10 AKAP8 KPNA3 ATG9A DNAJB1 STX7 POLR2C PPP1R7 UBE4A RAB30 SH3BP4 IQGAP3 GEMIN7 RAB5C NF2 PDLIM7 MPZL1 SLC1A4 SLC12A2 CORO1C GALNT7 GALNT1 AP3D1 CD164 ARCN1 BRPF3 TMEM59 GNL3L SPCS3 CPOX SLC25A1 STRN DOCK5 FMNL2 NEDD4 FADS2 CALCOCO2 LAMTOR5 SNAP23 FADS1 DOCK7 BET1 TNFAIP2 CDIPT TMEM109 ACP2 HEL-S-108 SNAP29 SCYL1 VCAM1 HSDL1 TGFBR2 ARID1A RCN2 RFT1 RBMS1 LUZP1 NUFIP2 NXN ABHD11 UHRF1 CAND1 TP53INP1 RRP8 IGF2BP1 LOC541469 ZNF622 HOXA5 LPL SLC25A24 OTULINL NHERF2 CEP72 MAP3K8 SLC4A7 VTI1B RQCD1 BRI3BP HSD17B12 SLC25A32 FERMT2 HOXD8 ELMOD2 RCOR1 MEOX2 VAMP3 PURA TAF9B MTX1 TRMT1 LY6K GEMIN2 CEBPB MSI2 ARID2 NPR3 P4HA2 UTP15 TERT MARS2 PSAT1 RBM19 SLC25A22 SLC25A13 HMOX1 HEL-S-47e RHOB CXCL12 NT5C3A PPP3R1 TNFRSF10A PANX1 PPP5C PPP3CA SYNE2 SYNE1 TUBA1A TMEM43 SERPINE2 DCAF7 TCL1A KCNN4 BACE1 SAC3D1 MENT ADPGK PTRH1 UNC93B1 MYB EHMT1 RHEB GYS1 PKN2 PPIF CHAF1A PDE3A RTN4 UBE2S HEL-S-30 AP2A1 IFRD1 CYR61 COL4A2 PLAG1 PTPA GPD2 CAP1 ATP2A2 PHC2 IGF2R PISD SLC38A1 RDH10 LAMC2 LAMC1 SDCBP MYLIP TPM1 CDKAL1 KIT GAS2L1 HEL-S-66 NT5E TRPV6 EIF4E BCL2 CCND1 CYP1B1 ARL10 FGF2 ANXA2 FBXW11 CSNK1D ADIPOR2 FXR2 DDX5 EGFR E2F3 GSTM4 HEL-S-303 NARS1 RAB23 TYMS GFPT1 HEL-S-26 MTHFD2 ABCG2 DNMT3B MPDU1 ANAPC1 PLK1 CLDN1 YWHAQ PPP2R5C CDKN2A BCL6 MYO1E ABCF2 MRM1 ATG3 TNLG5A BDNF CYP51A1 HMGA1 HARS1 SUCLG2 AURKB PRKCI ATAT1 SYPL1 NOTCH2 NOTCH1 NELFCD PTBP1 DHX15 SMAD1 ITGA2 NRP1 CORI CYCLE%WIKIPATHWAYS_20260910%WP1946%HOMO SAPIENS Cori cycle HEL-S-68p HEL-S-162eP HEL-S-87p GPT HEL-S-49 INS SLC2A4 PGAM1 SLC2A2 PFKP HEL-S-133P 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260910%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways DBP EPHX2 NPC1 CYP27A1 CYP7A1 SLC27A5 THEM5 ACOT9 ACOT8 EBP ACOT7 ACOT11 ACOT12 BAAT DHCR7 ACOT13 AMACR NPC2 ACOT6 HSD11B1 HSD11B2 SLC27A2 ACOT4 RAS SIGNALING%WIKIPATHWAYS_20260910%WP4223%HOMO SAPIENS Ras signaling PDGFRA FGFR4 SYNGAP1 FGFR3 FGFR2 RELA IKBKB SHC3 FGFR1 CSF1R RASA2 PIK3CD CDC42 CHUK PAK1 RAP1A GAB2 PAK6 PAK4 GNB2 GNB1 GNB4 PLA2G2D GNB3 PLA2G12A PLA2G4F PLA2G12B KDR PLA2G4D MAPK9 PLA2G4E PLA2G4C PLA2G3 PLA2G10 MAPK10 KIT GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ABL2 KSR1 NTRK2 RAPGEF5 RAF1 IGF1R HTR7 ZAP70 SHOC2 SHC4 RASGRP4 SHC2 PLD2 RASGRP3 GNB5 RALB FLT4 RAB5B RAB5C RRAS2 SOS2 EGFR INSR MAPK8 NF1 RRAS PLA2G2A NFKB1 STK4 AKT3 RAB5A RALBP1 RALA SHC1 EXOC2 REL ARHA PIK3R2 PIK3R1 RASA3 CALML6 RIN1 MAPK1 CALML3 RASAL1 PLCG1 RAC1 CALML4 RASAL3 TTBK1 RGL2 AFDN LAT RASA4B MAPK3 PLAAT3 TNFSF6 KSR2 ETS2 RASA4 MAP2K1 PLA2G2F PLA2G2E MAP2K2 RASGRF1 PLA2G2C FLT1 BAD PTPN11 RASSF1 NTRK1 GRB2 ARF6 PLA2G5 SOS1 PLA2G6 GRIN2B BCL2L1 CALM1 PLA2G4B RASGRF2 NRAS HRAS EPHA2 GNG10 NGFR GNG12 GNG11 GNG13 GRIN1 PRKCB PRKCA GNGT1 TIAM1 FLT3 GNGT2 IKBKG PLA2G1B PLA1A PIK3R3 PLCG2 RAC3 PRKACG PLCE1 FOXO4 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260910%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis EPHA4 RIPPLY2 TBX6 WNT3A MESP2 HES7 LFNG HES1 NOTCH1 FGF8 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260910%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IFNG TGFB1 VIP IL5 CD80 IL12A IL10 IL2 CTLA4 IL4 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP23%HOMO SAPIENS B cell receptor signaling BASH RAPGEF1 CAMK2A CD22 ATF2 CBL CRK RELA NFKB1 IKBKB INPP5D PIK3AP1 CARD11 BCL10 CDC42 CD19 CHUK GAB2 NFKBIA GTF2I PTPN6 LAT2 BRAF MAPK9 MAPK4 GSK3B MAPK14 SHC1 PTPRC REL PIK3R2 PIK3R1 CD79B CD79A MAPK1 RAC1 NCK1 PLCG1 MAP3K7 CD81 MAP4K1 BCL6 MAP2K1 MAP2K2 DAPP1 BLK PTPN18 HCLS1 PTPN11 VAV1 CREB1 GRB2 SOS1 CR2 NFATC2 RPS6KA1 MAP2K6 JUN HRAS RAF1 MAX MYC PRKCB FOXO1 RASGRP3 TEC IKBKG GSK3A STM7 LYN SYK BTK PLCG2 PIP5K1A NFATC3 PIP5K1C CRKL PDPK1 MAPK8 FYN VAV2 LCK 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MAP4 AGXT DISC1 NFKBIA MYOD1 CALCRL CAPN10 IL13RA1 NDUFA10 RAMP1 JUN UGT1A10 PRL NEU4 RPS6 ASCL1 TNF D2HGDH UGT1A8 IRF8 PPP1R7 SH3BP4 EEF1A1 HAMP RAB27A GBX2 ABCA1 IL1B EGFR HES1 TWIST2 GPC1 PDCD1 MEF2C MAP1LC3A CALCA GAL3ST2 PDGFA RRAGA RRAGB RAC1 RRAGD UGT1A1 BOK CXCR4 PDX1 ACKR3 MROH2A CXCL12 DGKD HJURP ARF1 TRAF3 ERFE KLHL30 THAP4 AGAP1 MAP1LC3C SEPTIN4 OR6B3 TRPM8 OR6B2 UBE2F MTERF4 CALM1 COPS9 GABARAPL2 SNED1 RTP5 PER2 GABARAPL1 RNPEPL1 ING5 SEPT6 KIF1A ILKAP UGT1A4 SEPTIN2 AQP12B DKFZp762B153 UGT1A3 AQP12A UGT1A9 DUSP28 ANO7 UGT1A7 TRAF3IP1 GABARAP OTOS ARL4C USP40 ARF5 DTYMK NEDD8 ASB18 CENPA CYTH2 SPP2 PRLH ANKMY1 CYTH1 FARP2 MLPH HES6 CXCL11 RAB17 ASB1 ITGB3 GYS1 COPS8 ITPK1 MYOG HEL-S-28 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260910%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease AGTR1 FBN2 SMAD2 FBN3 MAPK14 SHC1 LTBP2 FBN1 RUNX2 TGFBR2 TGFBR3 FLNA ENG LTBP1 MAPK1 TGFBR1 MAPK3 CTGF SMAD4 POSTN NR2C2 ANGPT2 MAPK8 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260910%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2 CTGF TGFBR3 WWTR1 TGFBR2 SPARC SMAD4 POSTN YWHAG TGFBR1 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260910%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects MYB KLF2 RGS16 CXCL12 PRL ERBB4 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260910%WP474%HOMO SAPIENS Endochondral ossification TGFB1 FGF18 FGFR3 BMPR1A FGFR1 STAT5B GLI3 ADAMTS4 NKX3-2 CST5 MEF2C MGP IGF2 opn MMP9 GHR HMGCS1 RUNX3 ENPP1 THRA BMP7 FRZB STAT1 ACAN CDKN1C VEGFA COL10A1 CALM1 BMP6 ALPL DDR2 IHH COL2A1 IGF1R ADAMTS5 SCIN GH1 PTH1R KIF3A FGF2 TIMP3 RUNX2 SOX9 SOX6 SOX5 PLAT CAB39 PTH IGF1 CHST11 PTHLH PTCH1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260910%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F2 CYP4F3 CYP4F11 CYP4F8 CYP4F12 CYP26A1 CYP2C9 CYP27C1 CYB5R3 CYP11B2 CYP2S1 CYP1A1 POR CYP26B1 CYP4V2 CYP2R1 CYP3A43 CYP7B1 CYP2A7 CYP2A6 CYP26C1 CYP4A22 CYP1A2 CYP3A4 CYP7A1 CYP17A1 CYP4A11 CYP3A7 CYP2A13 CYP2F1 CYP51A1 CYP46A1 CYP8B1 CYP4Z1 CYP1B1 CYP2W1 CYP24A1 CYP20A1 CYP27A1 CYB5R1 CYP2U1 CYB5R4 CYP2E1 CYB5B CYP2C19 CYP4F22 CYP2C18 CYP27B1 CYP2B6 CYP4X1 CYP11A1 CYP2J2 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5408%HOMO SAPIENS 15q25 copy number variation RNMT HOMER2 NMBR SHANK1 RAF1 DNM3 EGF RYR1 SPCS1 AGAP2 HTT SHANK3 SH3GL3 RAMAC SYNJ1 ZNF592 TENT4B BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 FSD2 PDE8A AP3S1 WHAMM SEC11A NMB AP3B2 SPCS2 WDR73 ALPK3 ZSCAN2 AP3D1 BNC1 RYR2 SPCS3 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260910%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFB HIF1A HES1 HIF1AN VEGFC VEGFA DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260910%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development EIF2B5 CSNK1A1 REST NEUROG2 MTOR GSK3B NFATC1 APP CDKN1B CRY2 RBL1 CASP9 E2F4 E2F5 CASP3 RPTOR MLST8 CREB1 TFDP1 TFDP2 TSC1 AKT1S1 TSC2 PSENEN DCAF7 RBL2 BACE1 CDK6 SIRT1 AMPH CDK4 CCND1 SPRY2 DNER FGF2 FOXO1 DYRK1A GMNN DEPTOR LATS2 NOTCH1 RBBP4 LIN54 LIN52 TFDP3 PSEN1 LIN37 H3F3B LIN9 HES1 TFAP4 HES5 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260910%WP2795%HOMO SAPIENS Cardiac hypertrophic response TGFB1 PLA2G2A TNFRSF1A CALM1 NFATC2 NFKB1 FGFR2 IKBKB MAP2K6 PPP3CA MAP2K3 MAP3K1 CHUK RAF1 MAP2K5 NRG1 EGF MAP3K14 MAPK7 IKBKE MTOR GSK3B MAPK14 FGF2 TNF PRKCA IKBKG CDK7 PRKD1 HDAC5 MAPK1 RAC1 MAP3K7 HDAC7 TGFBR1 MAPK3 NPPA PRKG1 MAP4K1 MAP2K4 MAP2K1 IGF1 MAP2K2 CDK9 PDPK1 CAMK2D MAPK8 GUCA1A STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis AKR1C1 AKR1D1 HSD3B2 SRD5A2 CYP11A1 CYP17A1 HSD3B1 CYP21A2 IL18 SIGNALING%WIKIPATHWAYS_20260910%WP4754%HOMO SAPIENS IL18 signaling SLC12A3 IMP3 IL37 GRIN2B TNFRSF1A RELA NFKB1 IKBKB IL18 TRAF6 CHUK NFKBIA TICAM2 IRAK1 NCF1 BAX CYCS MAPK9 MYD88 IL18RAP NCF2 ELAVL1 GSK3B GATA1 CEBPB PRKCB TNF IRF-1 PRKCA PIK3R1 IL18R1 MAPK1 ACACB MAP3K7 HEL-S-102 SP1 MAPK3 TNFSF6 PTEN CASP3 NFATC4 PRKAA1 CASP8 CSN2 RPS6KB1 LCK PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260910%WP4022%HOMO SAPIENS Pyrimidine metabolism CDA TK1 ENTPD3 NME3 CTPS2 NME4 DCTD NME6 CMPK1 POLD3 POLR2A CMPK2 POLD4 UPRT DCTPP1 POLR2B TYMS POLR2J3 POLR2G DUT POLD2 POLR2H POLR2J2 POLR2I UCK2 POLR2J UCK1 POLR2K POLR3B POLR1A CAD POLR3D POLR3E POLR1D POLR3GL POLR2D POLR3A POLR3H POLR2L RRM1 POLR3C POLR3F POLR3K RRM2 POLR3G NME2 POLR1F POLA1 POLR1H POLE4 POLE2 ENPP1 POLE3 DPYD DPYS HEL74 UMPS TYMP RRM2B DHODH PRIM2 PRIM1 ENTPD1 ENPP3 POLA2 POLR1C DTYMK NME7 POLR2C PNPT1 POLE PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260910%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling HK3 GSK3B CD80 IL10 TSC1 RELA NR1i1 PRKAA2 PDHA1 SLC2A3 PFKFB4 TSC2 IL12A RXRA MYC MTOR HEL-S-133P CYP24A1 IL2 SIGNALING%WIKIPATHWAYS_20260910%WP49%HOMO SAPIENS IL2 signaling GRB2 SOS1 RPS6KB2 CBL IL2RG JAK3 IL2RA IL2RB STAT5B IL2 GAB2 HRAS RAF1 NMI CISH RPS6 SHC1 PTK2B PIK3R1 SOCS3 FOXO3A MAPK1 MAPK3 SYK JAK1 MAP2K1 MAP2K2 STAT1 CRKL STAT3 PTPN11 FYN RPS6KB1 LCK TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260910%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly HIST1H4L CHAF1B CHAF1A RBBP4 HIRA SMIM40 H2BC12 H4C9 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260910%WP5087%HOMO SAPIENS Pleural mesothelioma FZD9 VGLL4 MEF2D CDH6 CDH19 FZD8 CDH2 CDH24 FGF18 ITGA6 FGFR4 FGFR3 CDH16 FGFR2 FGF10 FGFR1 WNT2B SETD5 SRC PIK3CD ACTG1 RASSF7 PAK1 PS1TP5BP1 PAK6 MAP2K5 PAK4 WNT16 RNF2 LRP5 SETDB1 MAPK9 EED MAPK7 CHD8 YY1 WNT7B MAPK14 MAPK10 MCL1 CDKN1A CDK7 BBC3 IDO1 CCND3 CCND2 EZH2 WWTR1 BTC HBEGF CREB1 ASXL1 WDR5 BAP1 TEAD2 CCNE1 CIT MAD2L1 NTF4 FLT3LG PIGF TSC2 MAX KMT2C CDK4 CDK2 MDM2 BAX CYCS ANGPT2 ATM ANGPT1 VEGFC RPS6 FOXO1 EIF4EBP1 INS HIF1A AJUBA CTBP1 RYK ROR1 NF2 ROR2 CTHRC1 CCL5 INSR TGFB1 NFKB1 SELE SLC3A2 RPS6KA5 CCL2 UHRF1 CSF3 CSF2 CTGF HEL-S-104 HGF MMP2 MMP9 PDGFA TGFA TERT YAP1 CCL4 HEL-S-31 LIMD1 ACTG2 MAP4K3 TEAD3 TEAD4 MAP4K1 MAP4K2 MMP3 LATS1 DKK2 RPTOR ACTA1 DKK4 ULK2 CXCL12 ULK1 CSF1 MMP14 MLST8 NLRP3 VEGFA TSC1 hCG_2014051 STK38L SETD2 TNIK AKT1S1 HRAS PLCB4 EPHA2 PPARGC1A PDGFD PDGFC FGF21 NGFR RHEB PRKAB2 PRKAA2 FLT3 PRKAG1 MOB1A PRKAG2 MAP3K5 LATS2 SUZ12 PRKAB1 PRKAG3 VEGFB VEGFD RBBP4 CD47 KITLG AGER PRKAA1 DKFZp781B1423 PDGFRA ATF2 COL4A2 COL4A1 COL4A4 COL4A6 RB1CC1 SOX17 CSF1R TRAF2 CER1 EFNA4 SFRP5 EFNA1 CTBP2 NTF3 EFNA3 PORCN FGF14 EFNA2 RASSF2 RASSF3 KREMEN1 RASSF4 SENP2 RASSF6 CDH8 PHC1 CXXC4 PRSS23 DSC3 WIF1 BAG2 FGF13 KDR RING1 FGF12 MDK NOTUM MOBKL1A LAMC2 LGALS9 LAMC1 HMGN1 NGF ACTA2 SFRP1 LAMA5 KIT LAMA1 LAMA4 LAMA3 EFNA5 EIF4B ANGPT4 LAMB3 LAMB2 LAMB1 TNNT1 IL34 RPS6KA1 NTRK2 MAP2K6 MAP2K3 JUN DKK1 MAP3K1 DDIT3 BCL2 SOST MAP3K10 RAF1 CXCL5 MAP3K11 FOSL1 CCND1 EGF MYC IGF1R FRAT1 FRAT2 CSNK2A1 BARD1 AREG CSNK2A3 CSNK2A2 BTRC SFRP4 CXCL1 WWC1 CSNK2B FGF2 DVL1 DVL2 FGF20 DVL3 FGF23 FGF22 DEPTOR FGF17 SP1 FGF19 FLT4 PTEN TTI1 IGF1 HCFC1 AXIN1 IL1B LEF1 EGFR MAPK8 BAK1 TCF7L2 EIF4G1 TCF7L1 CSNK1A1 APC RPS6KB2 CSNK1A1L ATF3 IGF2 FZD1 FZD3 WNT3A WNT7A LIN28B OGT WNT3 LRP6 AKT3 MAD1L1 MTOR GSK3B SHC1 HEL-S-1 MAPK1 CDKN2A MAP3K6 MAPK3 JAK1 COL4A3 MAP2K4 COL4A5 PRB1 MAP2K1 PRB2 MAP2K2 STAT1 MAPKAPK2 FLT1 SPARC FOXM1 RASSF1 BMI1 MINK1 IL6 NTRK1 RPS6KB1 GRB2 SOS1 MAP3K2 IL10 HMGB1 SLC7A5 GABPA KIF23 CD44 BDNF FZD10 CTNNA1 CTNNA3 CTNNA2 FGF3 FGF4 FGF6 FGF7 FGF8 FGF9 WNT5B ITGB1 ITGB4 ITGB3 WNT1 WNT4 ITGAV CDH9 WNT10B AMOT WNT10A CDH4 ITGA4 CDH10 FZD2 CDH11 FZD5 ITGA2 CDH12 ITGA1 CDH15 FZD7 CDH17 CDH18 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260910%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression TSC1 EIF4EBP1 PIK3R2 PIK3R1 EIF4E MAP2K6 MAP2K3 MAPK1 PIK3CD MAP3K5 TSC2 MAPK3 PIK3R3 RAF1 MAP3K11 MAP2K1 HEL164 MAP2K2 PRKAA1 MTOR TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260910%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis CEBPA IRS1 CEBPB TNF FOXO1 CEBPD LPIN1 LEP PCK2 TWIST1 NR3C1 PPARG SLC2A4 RXRA PPARGC1A INSR MAPK8 IL6 CREB1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260910%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma SHOC2 NFKB1 PARK2 HMGB1 DKFZp762B153 SQSTM1 PINK1 TFEB NFE2L2 MDM2 STAT3 AGER VMP1 IPO8 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260910%WP465%HOMO SAPIENS Tryptophan metabolism AANAT TPH2 ECHS1 ALDH2 ACAT1 IL4I1 CYP1A1 DLD AOC1 ALDH8A1 DDC AADAT GCDH HAAO MAOA GOT2 ASMT KMO TDO2 KYNU AFMID AOX1 KYAT3 KYAT1 IDO2 IDO1 INMT STAT1 TPH1 AHR FANCONI ANEMIA%WIKIPATHWAYS_20260910%WP5465%HOMO SAPIENS Fanconi anemia RAD51C FANCD2 SLX4 FAAP24 CEBPD MRE11A BRIP1 RFWD3 UHRF1 HEL-S-125m USP1 RAD50 RAD51 FANCM CENPX FANCL MEN1 FANCA CTDP1 ATM FANCB ATR DCLRE1B FANCE UHRF2 PALB2 FANCG FANCF SMARCA4 ERCC1 PTEN CENPS BRCA2 MAD2L2 NBN UBE2T EGFR REV1 MCM2 FAN1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members PARP10 PARP14 IKBKB NFKB2 EP300 CHUK NFKBIA TBK1 MAP3K14 SKP1 BTRC GSK3B ZC3HAV1 TIPARP TFPI2 PARP16 MAVS PARP12 CLDN6 IKBKG RIGI ERN1 CREBBP RELB RBX1 EGF EGFR SIGNALING%WIKIPATHWAYS_20260910%WP437%HOMO SAPIENS EGF EGFR signaling MEF2D CAMK2A TNK2 ATF1 CBL CRK AP2S1 INPP5D ROCK1 SRC STAT5B CDC42 GJA1 AP2M1 PAK1 RAP1A PIK3C2B GAB2 FOS CSK MAP2K5 CAV2 BRAF MAPK9 MAPK7 MAPK4 MAPK14 USP6NL STAMBP STAM2 HEL-S-34 EPS15L1 ASAP1 ATXN2 REPS2 NCK2 PTK6 CREB1 FOSB RPS6KA2 RPS6KA1 JUN MAP3K1 RAF1 COX2 EGF ERBB2 RICTOR SPRY2 PLSCR1 ITCH FOXO1 PLD2 EIF4EBP1 ARHGEF1 PTK2B SH3GL3 PXDN RALB SP1 NDUFA13 PTEN SH2D2A HGS SOS2 CRKL EGFR MAPK8 NEDD4 PTPN5 JUND RPS6KA5 MEF2C RAB5A MTOR RALBP1 RALA SHC1 PIK3R2 PIK3R1 SYNJ1 RIN1 MAPK1 INPPL1 PLCG1 RAC1 NCK1 CBLC JAK1 MAP4K1 MAP2K1 MAP2K2 EPN1 STAT1 STAT3 PTPN11 VAV1 RPS6KB1 GRB2 ARF6 SOS1 MAP3K2 LIMK2 HEL-S-15 HRAS NEDD8 IQGAP1 PRKCI GRB10 PRKCB PRKCA SH3GL2 PCNA PRKCZ PLCE1 STXBP1 VAV3 PDPK1 FOXO4 AP2A1 VAV2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260910%WP4666%HOMO SAPIENS Hepatitis B infection ATF2 RELA IKBKB BIRC5 EP300 JAK3 SRC PIK3CD STAT5B CHUK FOS TICAM2 TIRAP BRAF MAPK9 IFNB1 MAPK14 IFNA6 MAPK12 MAPK13 MAPK10 MAPK11 CREB3L2 CREB5 CDKN1A CASP9 TGFBR1 HSPG2 CASP3 APAF1 DDB2 CREB1 CREB3L3 CREB3L4 NFATC2 ATF6B MAP2K6 MAP2K3 JUN MAP3K1 IFNA13 BCL2 IFNA14 IFNA16 RAF1 IFNA17 IFNA10 IFNA21 BAX MYC CYCS IFNA5 IFNA4 HEL-S-93 IFNA8 TNF PTK2B SOS2 MAPK8 CASP8 FADD TGFB1 TICAM1 IRAK4 NFKB1 TGFBR2 EGR2 TRAF6 IRAK1 MAP3K7IP1 MYD88 AKT3 STAT4 MMP9 SMAD2 NFATC1 PIK3R2 PIK3R1 YWHAQ HEL-S-1 MAPK1 MAP3K7 MAPK3 JAK1 TNFSF6 MAP2K4 MAP2K1 CREBBP MAP2K2 STAT1 VDAC3 BAD IFNA1 STAT3 ATF4 TYK2 TRAF3 IL6 GRB2 IRF7 SOS1 CXCL8 CREB3 IFNA2 CASP12 NRAS HRAS TLR4 DDX3X TLR3 IFIH1 TBK1 CASP10 STAT2 IKBKE IRF3 PRKCB IFNA7 IFNAR1 PRKCA MAVS ARAF RIGI IKBKG PCNA PIK3R3 NFATC3 NFATC4 SMAD4 DDB1 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260910%WP3929%HOMO SAPIENS Chemokine signaling ITK CCL20 CRK RELA IKBKB SHC3 ROCK1 ROCK2 JAK3 PXN PIK3CD STAT5B CDC42 CHUK PAK1 RAP1A NFKBIA CSK GNB2 GNB1 GNB4 BRAF GNB3 CXCL16 WAS GRK5 GRK4 PREX1 GNG3 ELMO1 GNG2 DOCK2 GNG5 PRKX GNG4 GNG7 GNG8 IL8RB CXCR6 CCL15 c-fgr CCL27 CCL25 CCL26 CCL24 CCR10 CCR1 XCR1 CXCL3 RAF1 CXCL5 XCL1 CCR7 CCL7 CCR4 ADRBK1 SHC4 SHC2 PTK2B GNB5 NFKBIB LYN CXCR3 PARD3 WASL SOS2 CRKL CCL5 NFKB1 PF4 GNAI3 CCR3 CCR2 GRK1 AKT3 GSK3B SHC1 PIK3R2 CCL28 PIK3R1 FOXO3A CCL4 MAPK1 RAC1 CCL3 MAPK3 MAP2K1 ADCY1 STAT1 CXCL9 CXCR4 CXCL12 STAT3 CXCL14 VAV1 GRB2 SOS1 CCL11 ADCY3 CXCL13 ADCY6 CCL17 GNAI1 ADCY5 NRAS CCL22 PPBP HRAS DKFZp686L0365 PLCB3 CX3CL1 PLCB4 ADCY8 ADCY9 PLCB1 NCF1 PLCB2 CXCR5 GNG10 CCL19 STAT2 GNG12 CCL21 GNG11 CXCL11 GNG13 PRKCB GNGT1 TIAM1 GNGT2 IKBKG PIK3R3 PRKCZ PIK3R5 CCR8 PRKACG CCR6 VAV3 CX3CR1 VAV2 CCL1 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260910%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling DAGLA TRPC1 CCKBR RYR3 PLCB1 CNR1 RYR1 RYR2 GNAI1 CCK DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260910%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260910%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCB3 PLCG2 PLCL1 PLCE1 PKD1 PLCB1 PLCB2 FFAR1 GNA11 PLCG1 PLCH1 PLCD3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260910%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells EIF4G1 RPS6KB2 RPS6KA2 RPS6KA1 EIF4E MAP2K6 MAP2K3 RPS6KA5 MAP2K5 PIM1 MAPK9 AKT3 MTOR CSNK2A1 RPS6 MAPK14 EIF4EBP1 PRKCA MAPK10 EIF4A1 PIK3R2 PIK3R1 PIM2 MAPK1 RPS6KA4 MAPK3 PIK3R3 MAP2K4 MAP2K1 RPTOR MAP2K2 EIF4B EIF4A2 MAPK8 RPS6KB1 LIPOPROTEIN METABOLISM IN PERIPHERAL TISSUES%WIKIPATHWAYS_20260910%WP5620%HOMO SAPIENS lipoprotein metabolism in peripheral tissues APOC3 LPL APOE LIPC APOC2 APOB PLTP FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP143%HOMO SAPIENS Fatty acid beta oxidation CHKB HEL-S-49 GPD2 ECHS1 DECR1 ACAT1 CPT2 LPL DLD LIPF LIPC GCDH CPT1A PNPLA2 ACSL6 ACSL5 ACSS2 ACADVL ACSL3 FACL4 HADHB ACADL SLC25A20 ACADM LIPE ACADS CRAT ACSL1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260910%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders APTX SLC52A2 COQ6 SLC52A1 COQ2 PDSS1 ETFA COQ8A COQ9 COQ7 FLAD1 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260910%WP619%HOMO SAPIENS Type II interferon signaling EIF2AK2 ISG15 IRF2 SPI1 IFNA2 SOCS1 IFIT2 PSMB9 IFNG HLA-B MHC2TA NOS2 STAT2 IFNGR2 IFNB1 IFNGR1 IRF9 IRF-1 SOCS3 H4C9 CYBB IRF4 IRF8 JAK1 STAT1 CXCL9 IFI6 IL1B PTPN11 GBP1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260910%WP4747%HOMO SAPIENS Netrin UNC5B signaling PLEKHH1 UNC5B CIP2A MYF5 IL10 PTPA VCAM1 INPP5D SELE SRC JUN RGMA CCL2 ALPL IL1A PPP2R1B RAF1 CTGF KDR ROBO4 COL1A1 MAPK14 AGAP2 TNF ITGB4 PRKCA DCSTAMP ARHA PTK2B YAP1 NTN3 MAPK1 ARHGEF12 RAC1 NTN1 MAPK3 CASP3 MAP2K1 MAP2K2 PTPN11 FYN RLF PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer RICTOR GSK3B GRB10 RHEB FOXO1 EIF4EBP1 PIK3R2 PIK3R1 RB1CC1 FOXO3A CDKN1B MAPKAP1 TSC2 NRAS HRAS PIK3R3 PTEN TFEB RPTOR BAD ULK1 MLST8 FOXO4 MTOR MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260910%WP4318%HOMO SAPIENS Mitochondrial fission and fusion SH3GL2 FIS1 MTFP1 BCL2L1 MFN1 MFN2 BAX BNIP3 MIB1 OPA1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260910%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome GRB2 PLN IFITM1 NFATC2IP HEL-S-62p TRAF1 TUFM CR2 NFATC2 ATXN2L RABEP2 CD82 SPNS1 ATP2A1 MPL TRAF2 CD19 IL4 SH2B1 KDR RAB5A SLN SDCCAG8 LAT RAB4A CD81 INSR PRMT1 VAV2 APOPTOSIS%WIKIPATHWAYS_20260910%WP254%HOMO SAPIENS Apoptosis TRADD RIPK1 FADD CRADD HELLS TRAF1 TNFRSF1A RELA NFKB1 IKBKB BIRC5 TNFRSF21 TRAF2 CHUK NFKBIA IGF2 DIABLO TNFSF10 IRF-1 MAPK10 PIK3R1 MCL1 LTA BCL2L11 BBC3 TNFRSF1B CASP9 DFFB CASP6 DFFA CDKN2A HRK CASP2 TNFSF6 CASP4 MAP2K4 CASP3 BOK IRF6 TP73 TNFRSF25 BAD APAF1 TRAF3 BNIP3L IRF7 BCL2L2 IRF2 BCL2L1 PMAIP1 SCAF11 JUN MAP3K1 TNFRSF10B BCL2 MDM2 PRF1 CASP10 BAX IGF1R MYC CYCS BIRC2 BIRC3 IRF3 NFKBIE TNF NFKBIB IKBKG IRF4 IGF1 TP63 CASP8 BAK1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260910%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity F2 PLA2G7 MMP9 F2R NFKB1 FCER1A IL18 IL1R1 CCL2 HEL-S-134P S100A9 IFNG IRAK1 TLR1 CCR3 IL1B MYD88 HBEGF NLRP3 TIMP1 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260910%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 EIF4G1 CEBPA USF1 BCL2L1 EIF4E TPM3 DLGAP4 TTC9 GJB2 GAL STAT5B USF2 HDGFL2 CHUK NRG1 CCND1 PRL MYC ERBB2 TNFSF11 ELF5 PGR YY1 PRLR NR3A2 CEBPB ORAI1 TFPI2 PTPN1 CLDN6 NFIA NFIB NR3C1 EGFR ERBB3 TNFRSF11A ERBB4 CSN2 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260910%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SLIT2 ROBO4 SRC KDR RAC1 VEGFA ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260910%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP1 SP3 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260910%WP1984%HOMO SAPIENS Integrated breast cancer pathway MSH2 ATF1 BMPR1A EP300 BMPR2 CDC42 CHUK PAK1 RAP1A RHO HMGCR DAG1 BRAF RB1 RPP38 CDK7 CASP9 AURKA PKIA TGFBR1 CHEK2 CASP3 CHEK1 BACH1 CREB1 FOSL2 SMEK1 NUP85 GADD45A TPR JUN MRE11A PPP4R3B EDAR PML TSC2 ZMYND8 NAB1 BCL2 WEE1 MAP3K7CL RAD50 ALKBH1 RALGAPA1 RAD51 CCNB1IP1 LGALS13 MAX CDK4 PLK3 FOSL1 FER CDK2 CCND1 MDM2 PIGR APOBEC3G RASGEF1A BAX MYC DCAKD ITPKC USP15 TFPI ATM USP16 BLM USP21 BARD1 ATR FILIP1 NOXA1 IRS1 MYCBP2 FOXO1 RASGRP3 CERK CSNK1D GSK3A SP1 PTEN BRCA2 MYT1 EGFR CASP8 BAK1 NF1 TRADD HIPK2 RRAS FADD NFKB1 TGFBR2 SMAD6 MAP3K7IP1 ZNF655 CDC25B MTOR SELENOK RALA SMAD2 PLK1 HDAC1 PIK3R2 MAPK1 RAC1 ZMIZ1 JAK1 ANXA1 STAT1 BAD MAP3K13 AHR VEGFA UBE2F TSC1 GRN SIRT1 FAU PIAS1 RHEB DHTKD1 ARAF XRCC3 SMARCA4 ERAL1 GDI1 SMAD1 SMAD4 MSH6 STK11 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders GALNT3 opn KL ORAI1 FGFR3 NFKB1 FGFR2 NFKB2 CDKN1A DMP1 FGF23 ALPL ENPP1 CYP11B2 CYP27B1 PTH SLC34A3 ROS1 CCND1 FAM20C SLC34A1 CYP24A1 MITOPHAGY%WIKIPATHWAYS_20260910%WP5636%HOMO SAPIENS Mitophagy SIAH1 EIF2S1 PGAM5 PARK2 TRAF2 SRC OPA1 BECN2 AMBRA1 FIS1 TOMM40 MAPK9 RAB5A TOMM20 VCP MAP1LC3A MTX1 MAPK10 PHB2 MFN1 MFN2 FOXO3A MARCHF5 NBR1 AMFR SMURF1 PINK1 ARIH1 ULK1 ATF4 BNIP3 ATG9B BNIP3L BCL2L1 JUN SQSTM1 TBK1 USP15 CSNK2A1 CSNK2A3 CITED2 CSNK2A2 FUNDC1 USP30 MUL1 NLRX1 RAB7B RHOT1 OPTN RHOT2 BCL2L13 SAMM50 HIF1A TBC1D17 RAB7A TBC1D15 HUWE1 CCZ1 TOMM7 SP1 ATG9A RAB5B RAB5C TFEB TOMM70 MAPK8 CALCOCO2 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260910%WP5234%HOMO SAPIENS Bardet Biedl syndrome IQCB1 TRIM32 BBS10 BBS12 GPR161 WDPCP ARL6 EFHC2 RAB23 GLI3 SCLT1 INVS CEP164 SUFU CLUAP1 BBS9 BBS7 BBS5 CEP290 RP2 TMEM216 CEP104 ARL3 BBS4 USP9X ARL13B TMEM67 INPP5E CRX PDE6D NPHP3 MKS1 BBS2 NEK8 BBS1 TTC8 CEP41 ZIC2 NEK1 TRAF3IP1 CFAP418 CFAP410 PKD1 LZTFL1 DYNC2H1 DYNC2I2 PKHD1 IFT140 DCDC2 DYNLT2B IFT80 WDR35 DYNC2LI1 EVC2 IFT43 KIF7 IFT81 EVC SMO IFT27 EFHC1 FUZ BBIP1 SCAPER SDCCAG8 FLCN PKD1L1 CNGA1 IFT172 IFT74 PCARE IFT52 OCRL TMEM107 IFT57 CNGB1 PTCH1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260910%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission AP2A2 NTRK2 ROCK1 BDNF GABRB3 GABRB2 NGFR GABRB1 GABRE GABRQ GABRA2 SHC1 GABRP ARHA PIK3R2 GABRA6 PIK3R1 GABRA5 GABRA4 GABRA3 SLC12A5 PLCG1 GABRG3 GABRG1 PIK3R3 PTEN STAT3 CREM CREB1 AP2A1 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260910%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system ISG15 APC HEL-S-67p TUBA2 BIRC5 EP300 DLG2 PARK2 PXN TWIST1 CDC20 SNCA HSF1 POU5F1 CD133 MYD88 HEL-S-32 VCP CFTR MAP1LC3A GSK3B SMAD2 HEL-S-2a FOXP3 MAPK1 RAC1 KAT5 AURKA MAPK3 MYH9 HEL-S-72p SNCAIP STUB1 TUBA1C SIRT2 TARDBP SQSTM1 BDNF BCL2 TUBB SGK1 ITIH4 EP400 VHL BAX HEL113 FAT10 FUS CSNK2A2 ADRBK1 DCTN1 FREP1 CSNK2B HTT ELP3 PRKCE RHOT1 OPTN SHH PTK2B HIF1A MAP1B BBIP1 MAPRE1 GSK3A HDAC11 MAP3K5 IKBKAP HEL-S-102 CYBB SP1 TUBA4A NEDD9 KALRN PRKCZ ATXN3 CCDC141 HSPA4 NR3C1 ERG MIIP APOE ARID3A GARS1 GRIA2 CNOT6 DLG4 EGFR MAPK8 HEL-S-44 MTHFR DEFICIENCY%WIKIPATHWAYS_20260910%WP4288%HOMO SAPIENS MTHFR deficiency GRIN1 EHMT1 MARS1 ASMT PEMT HEL-S-61p CHPT1 ALDH7A1 CASP9 CASP3 CHDH DNMT3B CHKA CYCS GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260910%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease SHCBP1 ARHGAP31 IBTK SBDS NFKB1 EIF6 CDC42 KCNN3 GTF2I TLR8 TLR9 COX4I2 NCF1 RBPJ NCF4 DLL4 CYBA NCF2 MAPK1 RAC1 NOTCH1 NOTCH4 CYBB SP1 MAPK3 BTK NOX3 DOCK6 CYBC1 CXXC5 CHCHD2 C4orf54 BEND6 DGUOK EFL1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260910%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance RRAS PDGFRA RPS6KB2 FGFR3 FGFR2 SHC3 SRC PIK3CD NRG1 AXL BRAF HGF KDR AKT3 MTOR GSK3B SHC1 PDGFA PIK3R2 TGFA PIK3R1 FOXO3A MAPK1 BCL2L11 PLCG1 IL6R MAPK3 JAK1 MAP2K1 MAP2K2 NRG2 BAD STAT3 ERBB3 IL6 VEGFA RPS6KB1 GRB2 SOS1 BCL2L1 EIF4E NRAS HRAS BCL2 RAF1 CCND1 EGF BAX IGF1R MYC ERBB2 PDGFD PDGFC RPS6 FGF2 PRKCB SHC4 PRKCA SHC2 EIF4EBP1 ARAF PIK3R3 PTEN PLCG2 IGF1 RRAS2 SOS2 EGFR PDPK1 NF1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260910%WP3925%HOMO SAPIENS Amino acid metabolism PPM1L VARS1 CTH HEL-S-64p IARS ASNS HEL-S-61p FTCD HEL-S-26 HEL-75 PDK4 PCK1 GCLM PIG59 CAD HEL-S-32 GLS GLUD1 DDC SRM ACSS1 HDC GOT2 P4HA2 TDO2 MARS2 OGDH ALDH18A1 PC EPRS1 TPH1 RARS1 ADH1C HAL ACO2 DBH GPT2 ADH7 MCCC1 HEL-S-53e EHHADH HEL-S-4 SDHA HMGCL BCAT1 TH DLD G6PC2 TPO CS MDH2 PDHX FH ADH5 SUCLG1 ARG2 ARG1 PNMT LARS2 MAOA ASS1 SMS PDHA1 ALDH7A1 OTC ACADM ACLY CBS FARSB HEL-S-30 HEL-S-133P GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260910%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C HEL-S-30 PFKP HEL-S-133P PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260910%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins LAMP2 VPS39 VPS33A GABARAPL2 ATG2B ATG3 VAMP8 RB1CC1 ATG12 AKT1S1 DKFZp762B153 SQSTM1 LAMTOR1 ATG16L1 VPS41 MTOR RPS6 RHEB OPTN VPS18 PRKAA2 LARP1 NBR1 RAB7A APOB DEPTOR VPS16 ATG9A PPP1R9A RPTOR EIF4B ULK1 TMEM59 MLST8 CALCOCO2 HEL-S-30 DKFZp686F0183 RPS6KB1 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260910%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling TNFRSF1A NFKB1 EIF4E AKT1S1 MAPKAP1 TNLG5A FBXO32 IGFBP5 IGF1R PPARGC1A EIF2B2 MTOR ACVR2B MSTN MAP1LC3A RICTOR TRIM63 ITGB1 GSK3B IRS1 SMAD2 DEPTOR PRKAB1 PTEN IGF1 WASL RPTOR MLST8 HEL-S-28 RPS6KB1 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome NEIL2 PINX1 HEPACAM2 C8orf7 CLDN23 SLC35G5 PRSS55 CSTA PRSS51 DEFB136 SOX7 C8orf74 DEFB135 DEFB134 TBX5 MFHAS1 FAM167A NKX6-1 HSPD1 FDFT1 S100A10 BMP1 SLBP TERT MAPK1 TERF1 MAPK3 GATA4 BLK PDX1 NUMA1 FCGR2A PPP1R3B TNKS CGAS MSRA RAF1 TLR4 HEL-S-130P SLC2A4 FCGR2B ERI1 MTMR8 MTMR9 MCRS1 MTMR6 AXIN1 SGPL1 RP1L1 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260910%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes TMSB4X HAND2 IGF1 KCNJ2 ERG HCN4 KCNE1 HCN2 GJA1 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer FZD9 MEF2D CDH2 FZD8 SNAI1 SNAI2 COL4A2 COL4A1 COL4A4 TJP1 COL4A6 WNT2B PALS1 PIK3CD VTN PAK1 WNT9B WNT9A WNT16 LRP5 WNT8A WNT8B DLL3 DLL4 CLDN2 EED PKP2 WNT7B MAPK14 GDF15 MAPK12 MAPK13 MAPK11 CLDN6 JUP TGFBR1 EZH2 FOXC2 MAP2K6 FOXQ1 MAP2K3 ID1 CLDN11 RAF1 PKD1 GIG8 HIF1A CTDSP1 CLDN4 SOS2 MAPK8 FMNL2 NRP2 TGFB1 TWIST2 TGFBR2 ZEB2 TRAF6 TUSC3 CLDN23 TWIST1 FZD1 FZD3 WNT3A WNT7A PROX1 HEL-S-79 WNT3 CDKL2 CLDN9 LRP6 AKT3 CLDN7 MMP2 PKP1 EIF5A2 CLDN22 CLDN20 MMP9 CLDN24 SMAD2 GSK3B CLDN10 SHC1 CLDN15 CLDN14 CLDN19 PIK3R2 STRAP PIK3R1 CLDN18 CLDN1 CLDN17 CLDN16 MAPK1 CRB3 MAPK3 COL4A3 MAP2K4 COL4A5 MAP2K1 MAP2K2 SPARC FOXM1 NR2C2 MMP15 GRB2 SOS1 HRAS FZD10 RBPJ CLDN5 CLDN3 TMPRSS4 WNT5B NOTCH2 NOTCH3 NOTCH1 LATS2 SUZ12 NOTCH4 PIK3R3 WNT1 WNT4 JAG2 RBBP4 WNT10B WNT10A SMAD4 FZD2 FZD5 NUBPL FZD4 FZD7 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260910%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway TGFB1 RPS6KB2 RELA NFKB1 IKBKB TGFBR2 PIK3CD CDC42 CHUK PAK1 PAK6 PAK4 BRAF MAPK9 AKT3 MTOR RALBP1 RALA SMAD2 MAPK10 PIK3R2 RB1 TGFA PIK3R1 CDKN1A MAPK1 dik HEL-S-34 RAC1 CASP9 TGFBR1 MAPK3 CDKN2A JAK1 MAP2K1 MAP2K2 STAT1 BAD STAT3 DDB2 VEGFA RPS6KB1 BCL2L1 GADD45B GADD45A GADD45G RAF1 CDK6 RAD51 CDK4 CCND1 EGF BAX ERBB2 PLD2 ARAF IKBKG RALB PIK3R3 BRCA2 RAC3 POLK EGFR SMAD4 E2F2 MAPK8 E2F3 BAK1 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260910%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions TEAD2 STK38L CD19 RAP1A LPL CCR7 MAPK14 FYB1 FOXO1 FOXP3 ARHA YWHAQ FOXO3A YAP1 RAC1 MOB1A FOXO6 LATS2 KNSTRN RAB13 FERMT3 TEAD3 TEAD4 LATS1 WWTR1 FOXO4 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260910%WP2806%HOMO SAPIENS Complement system IBSP HEL-S-78p CSNK1A1 MBL2 PRNP SELPLG ALB SELE C5AR2 SELP THBS1 GNAI3 SERPING1 CD19 VTN KLKB1 RPS19 C1QBP CPN1 SELL LAMC1 opn CRP WAS DCN SFTPA2 CFP LAMA5 VSIG4 CD93 HEL-S-92n FCER2 PTX3 FKBP2 GNA15 SFTPA1 CFHR2 FPR1 CFHR4 ELANE HEL-S-99n LAMB1 PROS1 C3AR1 HEL-S-62p CR2 CR1 PLAUR C8A C4A MASP2 TXN MASP1 F11 CD46 CFB ADM DKFZp686L0365 CFD CD40 C1S CFH ICAM2 CFI FCN1 C5AR1 FCN2 CLEC4M C4BPA C6 C7 C9 FCGR3A CD55 F10 F13A1 PRKCA ITGB3 ITGA2B CD59 PLG FGA ITGA2 BURN WOUND HEALING%WIKIPATHWAYS_20260910%WP5055%HOMO SAPIENS Burn wound healing FST SNAI2 FGFR4 FGFR3 NFKB1 FGFR2 FGFR1 CCL2 INHBA BRD4 TNC KRT6A LIN28A HGF MYD88 MMP2 IL15 IFNB1 MMP9 FBN1 CD3E DCN PECAM1 S100A6 S100A9 MMP28 CASP3 ACTA1 HEXD CXCR4 KRT222 IL8RB CXCL12 PCTK1 FLG TAGLN SCEL AMBP IL6 HEL-S-43 VEGFA SLURP1 TPT1 ACHE NOX4 CXCL8 IFNA2 KLF4 HMGB1 BCL2 TLR4 EGF BAX TIMP1 CXCL1 COL1A1 COL1A2 F13A1 TNF FOXE1 CHRNA7 IL1B LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2874%HOMO SAPIENS Liver X receptor pathway CYP3A4 CYP2B6 NR1H3 CYP7A1 SCD RXRA ABCG8 FASN ABCG5 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260910%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners MERTK SKI TEAD3 TEAD4 HDAC3 SIN3A TEAD2 LATS1 HDAC1 LATS2 SKIL NF1 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260910%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms AGTR1 MAS1 TMPRSS2 REN ACE2 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260910%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCD4 PI4K2B TPTE2 IPMK PI4KB INPP5D PIK3CD PIK3C2G PIK3C2B PLCB3 PLCB4 PLCB1 PLCB2 MTMR1 MTMR2 INPP4B MTMR8 PLCG1 STM7 MTMR6 MTM1 PIP4P2 PIP4P1 INPP4A PTEN INPP5E PLCG2 PIP4K2A PIP5K1A PLCE1 PIP4K2B FIG4 PIP5K1C PI4K2A SACM1L OCRL PIKFYVE PLCD3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome FMR1 TUBGCP5 TUBGCP6 NIPA1 TUBGCP4 NIPA2 CYFIP1 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260910%WP5390%HOMO SAPIENS Pancreatic cancer subtypes SPRR3 ST6GALNAC1 HEL-S-116 HEL136 CYP3A7 KRT20 GPR87 LGALS4 VSIG2 FAM83A AGR3 TNS4 FAM3D KRT6C FGFBP1 SERPINB3 TSPAN8 BTNL8 KRT7 ANXA10 SPRR1B LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 KRT6A VGLL1 CLRN3 TFF2 AREG PLA2G10 S100A2 DHRS9 REG4 LYZ CST6 SCEL CDH17 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260910%WP5559%HOMO SAPIENS Lupus pathogenesis CD80 IL17A ICOS IFNA2 BCR CD40LG PDCD1 TLR7 CD40 TNFRSF13C TLR4 TLR9 TNLG7A IL6 COCAINE METABOLISM%WIKIPATHWAYS_20260910%WP2826%HOMO SAPIENS Cocaine metabolism CYP3A4 BCHE CES1 CES2 TAR SYNDROME%WIKIPATHWAYS_20260910%WP5362%HOMO SAPIENS TAR syndrome RBCK1 CD3D NFKB1 ZFHX3 SLC34A3 POLR3GL CFTR POLR3C POLR3F POLR3G AKAP10 HDAC2 PEX19 CXCR4 STAT3 UBE2I FURIN TXN CD160 TNFRSF14 IFNG SLC22A4 HLA-B HLA-C SIRT1 LAMTOR1 HLA-A HLA-F HLA-G DDIT4 HLA-E ANKRD35 EIF4A3 CCAR2 GPR89B SLK FARP2 SUMO2 MAGOH NUDT17 HEL-S-76p ITGB1 PEX11B CLCN3 NHERF1 PYM1 PDZK1IP1 BCL2L13 MITD1 FLT3 HAMP EGFR LCK GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260910%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCI PRKCH PRKCB PRKCE NFATC1 PRKCA RCAN1 PRKCQ PPP3CA PRKD1 PKN3 PPP3CC PKN2 PRKD2 PKN1 PRKCZ PLCB3 ANGPT2 PPP3R1 PPP3R2 PRKD3 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260910%WP410%HOMO SAPIENS Exercise induced circadian regulation GSTM3 PER2 VAPA UCP3 PER1 G0S2 NCKAP1 KLF9 PIGF NR1D2 PSMA4 HLA-DMA IDI1 PURA CLDN5 QK3 CEBPB CBX3 DAZAP2 BTG1 STBD1 SUMO3 ETV6 CRY2 SUMO1 ERC2 RBPMS CRY1 ZFR MYF6 HEL-S-22 H2BC15 HEL-S-72p AAG1 TOB1 PPP1R3C GLYCINE METABOLISM%WIKIPATHWAYS_20260910%WP1495%HOMO SAPIENS Glycine metabolism HEL-S-51e SHMT1 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260910%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity TICAM1 IFNA2 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 TLR3 IFIH1 IFNA21 TBK1 IFNAR2 STAT2 IKBKE IFNB1 ACE2 IFNA5 IRF3 IFNA4 IFNA8 IFNA7 IFNA6 IRF9 IFNAR1 MAVS RIGI JAK1 STAT1 IFNA1 TYK2 TRAF3 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260910%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide MAP1LC3A IFNG IRF3 TLR4 TNF NFKB1 TLR9 TRAF6 MYD88 IFNB1 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260910%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling IBSP SMAD9 CDH2 TGFB1 PDGFRA SNAI2 COL4A1 RELA NFKB1 ZEB2 EGR1 TJP1 SOCS1 FGFR1 SRC RPS6KA5 CCL2 SMAD6 CSF3 FOS CSF2 DKFZp781O1323 NR0B2 FZD1 SIX1 KLK15 KDR MAPK9 MTOR IFNB1 MMP9 GSK3B SMAD2 MAPK14 SHC1 ACTA2 PIK3R1 CLDN1 SOCS3 MAPK1 PLCG1 RPS6KA4 MAPK3 MAP2K1 MAP2K2 FLT1 IL6 VEGFA RPS6KB1 GRB2 IL10 CXCL8 RPS6KA1 JUN SP7 CXCL5 RAF1 IGF1R PPARGC1A HEL113 RPS6 CLDN5 CXCL1 ITGB1 PRKCB TNF ACACA CXCL2 CPT1A PRKAA2 MST1R HEL-S-102 PCNA SLPI PTEN DUSP4 WNT10B SMAD1 CRKL IL1B PDPK1 MAPK8 HK2 BGLAP HEL-S-133P NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260910%WP4753%HOMO SAPIENS Nucleotide excision repair XPA XPC POLD3 POLD4 POLD2 GTF2H2C_2 RPA1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 POLE4 CUL4A CDK7 POLE2 RPA3 CCNH ERCC1 POLE3 PCNA CETN2 ERCC2 ERCC5 MNAT1 POLE CUL4B RFC3 RFC4 LIG1 RFC2 RFC1 RBX1 DDB2 DDB1 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260910%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1 GYG1 HEL-S-19 GYS2 PYGL GYS1 AKR1B1 SLC2A2 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome APC ARHA TUBA2 RAC1 AMER3 STMN2 MZT2A ARHGEF4 FAM168B CCDC74A CDC27 POTEE STAT3 GPR148 CCDC42 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway CYP1A2 TGFB1 SERPINB2 EP300 SRC JUN JUND UGT1A4 UGT1A3 IL2 SLC7A5 UGT1A9 UGT1A7 NQO1 IFNG IL12A CYP1A1 IL12B CAP2 CDC37 BAX AIP CYP1B1 PTGES3 IGFBP1 TNF CDKN1B MGST1 JUNB UGT1A1 NCOA1 POLK NFE2L2 MYOF ALDH3A1 IL1B AHRR EGFR AHR HES1 CES3 IL17B PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260910%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway SIAH1 TUBA2 CASK TUBA8 HEL-S-89n PSMD10 PARK2 PSMD5 TUBAL3 HEL-S-91n SNCA PSMD11 UBE2L6 UBE2J2 UBE2J1 UBE2L3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 GPR37 PSMD3 UBE2G1 PSMD1 UBE2G2 HEL-S-72p SNCAIP SEPT5 CCNE1 HSPA2 STUB1 TUBA1C TUBA1B HSPA1A TUBA1A TUBB TUBB2A TUBA3E FBXW7 TUBB4B TUBB4A PSMC6 PSMC4 PSMC1 TUBB8 TUBB6 TUBB1 SIAH2 TUBA4A HSPA4 PSMD12 PSMD13 RNF19A TUBA4B HSPA14 CASP8 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260910%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling RRAS DNER MAML3 NOTCH2 NOTCH3 NOTCH1 CHUK NOTCH4 JAG2 MAML2 MAML1 PSEN2 LEF1 RBPJ PSEN1 DLL3 DLL4 MFAP1 HES1 DLK2 MFAP2 ADAM10 METHYLATION PATHWAYS%WIKIPATHWAYS_20260910%WP704%HOMO SAPIENS Methylation pathways TPMT PNMT INMT NNMT MAT1A TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260910%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle SUCLG2 SUCLG1 ACO2 SDHC SDHD SDHA OGDH SDHB DLD CS MDH2 FH SUCLA2 IDH3B PDGF PATHWAY%WIKIPATHWAYS_20260910%WP2526%HOMO SAPIENS PDGF pathway GRB2 SOS1 NFKB1 SRC JUN MAP3K1 CDC42 PAK1 CHUK HRAS FOS NFKBIA RAF1 COX2 SHC1 ARHA PDGFA PIK3R1 TIAM1 MAPK1 PLCG1 RAC1 MAPK3 JAK1 MAP2K4 MAP2K1 WASL STAT1 STAT3 PTPN11 VAV1 MAPK8 VAV2 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids TSC1 ASAH2 NFKB1 SPHK2 HIF1A CERK IGF1R LASS1 S1PR1 S1PR3 MTOR FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260910%WP1601%HOMO SAPIENS Fluoropyrimidine activity FPGS UPP2 CDA TK1 ABCC5 GGH TYMS TDG DHFR UCK2 UCK1 SLC29A1 ABCG2 CES1 ABCC3 RRM1 RRM2 SLC22A7 SMUG1 XRCC3 ERCC2 CYP2A6 DPYD DPYS UMPS TYMP CES2 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway MVD MSMO1 HMGCR CYP51A1 SC5D DHCR7 FDFT1 FDPS HMGCS1 SQLE IDI1 MVK HEROIN METABOLISM%WIKIPATHWAYS_20260910%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES1 CES2 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260910%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways FZD9 ACTR3 FZD8 TMSB4X PFN4 APC PFN2 CBL GPX1 ROCK2 SRC DAAM1 PAK1 WNT16 FZD1 FZD3 NEF3 NEFH GSK3B SHC1 ARHA TGFA CDKN1A CDKN1B MAPK1 NCK1 PLCG1 MYL1 MAP2K4 MAP2K1 ACTR2 ACTA1 ERBB4 GRB2 SOS1 JUN RAF1 CAMK1 NEFL FZD10 MYC ERBB2 DVL1 PFN3 MYLK PFN1 PPP2CA AXIN1 EGFR FZD2 FZD5 MAPK8 FZD4 FZD7 HEL-S-44 LAC PHE PATHWAY%WIKIPATHWAYS_20260910%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260910%WP5360%HOMO SAPIENS KCNQ2 related epilepsies AGTR1 KCNQ2 KCNQ3 CALM1 PRKCA P2RY1 BDKRB2 PPP3CC BACE1 PPP1R10 PLCG2 STX1A AKAP5 SCN1B CHRM1 CSNK2A1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5153%HOMO SAPIENS N glycan biosynthesis MAN1A2 DPAGT1 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 B4GALT1 ALG5 RFT1 ALG6 ALG10 RPN2 TUSC3 MAN1B1 RPN1 ALG10B SRD5A3 ALG2 GANAB ALG14 MAN2A2 ALG13 MAN2A1 ALG3 MGAT5 MGAT5B DOLK ALG12 MGAT3 ALG1 MGAT4C ALG11 MGAT4D DPM1 MGAT4A GMPPB DOLPP1 DPM3 MGAT4B MGAT1 MGAT2 STT3A GCS1 STT3B MPDU1 DPM2 FUT8 DDOST B4GALT2 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260910%WP4595%HOMO SAPIENS Urea cycle and associated pathways HEL-S-281 GLUD1 GPT ARG1 GOT2 ASS1 SLC25A12 ASL NAGS SLC25A13 OTC NOS2 SLC25A15 MDH2 FH HEL-S-32 GLS2 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260910%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 AVPR1B AGTR1 ADAM17 ACE2 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260910%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CAMK2A CACNA1S CAMK2G ATP2A2 GJA1 CHRM4 GNB2 CHRM5 ADRB1 GNB1 GNB4 ADRA1D GNB3 GJA9 CACNB1 ATP1B3 CACNB3 SLC8A1 STIM2 GJC1 GJB4 GJB3 GJB5 CASQ2 ANXA6 ATP1A4 KCNB1 RGS4 RGS5 RGS1 RGS6 GJC2 GRK5 GRK4 PKIB PKIA PKIG RGS18 GNG3 RGS17 GNG2 GNG5 GNG4 RGS14 ADRB2 RGS16 GNG7 RGS20 GNG8 RGS11 SFN GJB2 GJB6 ADRA1B YWHAG HEL-S-93 GNB5 ADRA1A GJB1 CHRM3 ATP1B2 RGS2 KCNJ5 GNAI3 ATP2B1 FKBP1A HEL2 GNAO1 ATP1B1 RYR1 FXYD2 ORAI1 CASQ1 YWHAQ HEL-S-1 GJA3 GJA5 GJA8 ADCY1 KCNJ3 HEL-S-99n CHRM1 GNA11 GJA4 GNAZ ATP2B3 ATP2B2 PLN CALM1 RYR3 ADRB3 ADCY3 ADCY6 GNAI1 ADCY5 DKFZp686L0365 ITPR2 PLCB3 ADCY8 CAMK1 ADCY9 GNAS GNG12 GNG11 GNG13 PRKCH RGS10 PRKCB PRKCE PRKCA GNGT1 PRKCQ PRKD1 CAMK4 PRKCZ PRKAR1B PRKAR1A CACNA1C CACNA1B RYR2 CHRM2 CAMK2D CACNA1A NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260910%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SNAI2 SRC GPAM PDK4 PCK1 NR0B2 ABCG8 KLK15 ABCG5 IL11 GCC1 CDKN1B MYOF NCOA6 CDKN1C HBEGF SMC1A SLC7A11 GADD45B SLC6A2 SLC6A3 CDC2 NQO1 SLC5A7 CDK4 CDC37 BAX AMIGO2 BIRC2 BIRC3 ABCC3 ABCC2 FOXO1 SLCO1B1 FASN SLC27A5 DNAJB1 ACADM ABCB4 KAT2B TGFB1 TGFBR2 TGFBR3 NFKB2 SLC5A2 SLC6A20 CCL2 SLC27A1 CPT2 ME1 SERPINA1 APOA2 APOC3 IL12B FABP1 APOA5 SCD SLC6A18 HGF ANGPTL4 SLC5A8 PLTP SLC6A9 ALAS1 TGFA SLC2A3 HMOX1 NFE2L2 AHR PTGS2 ZIC2 SLC2A12 SLC5A5 SLCO2B1 ALOX5AP EPHA2 IP6K3 RXRA PPARGC1A SLC19A2 DNAJC7 SLC6A11 PDE4B IL17B AGER SLC5A1 ANKRD1 CCL20 PTPA EP300 FGF13 HSP90AB1 SLC2A2 IGFBP1 SLC39A9 FTH1 SLC39A6 ABCB1 SLC39A5 SLC39A8 SLC6A17 SLC6A16 SLC6A13 HEL126 ALDH3A1 SLC5A9 CES8 CES3 SRPX2 CES2 EPHA3 SLC5A3 SLC5A4 CYP1A2 SLC2A9 HEL-S-128m CYP3A4 SLC6A5 SLC6A7 SLC6A8 MAFF SLC2A6 SLC2A7 SLC2A8 SLC2A14 JUN SLC2A11 SLC2A10 ABCC5 TXN SLC2A13 HEL-S-25 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SMVT KEAP1 SLC5A12 CAP2 MAFG TNFAIP3 SLC5A10 CCND1 SLC2A4 MYC THBD FKBP5 CYP1B1 SULT2A1 DNER SPRY1 TNF CPT1A NR1I3 NR1i2 MGST3 NR1H4 MGST1 ABCB11 MGST2 CYP2C19 SP1 FGF19 SULT1A1 CYP2B6 POLK IL1B EGFR BHLHB2 HES1 GSTM4 GSTM3 FTL GSTM2 NR1i1 EGR1 EPB41L4B GPX2 ARL5B GSTM1 RGS2 CYP4F12 JUND ENC1 TNS4 GPX3 CYP2C9 GSTT2 SRGN FGFBP1 EDN2 TSC22D3 HEL-75 GCLC NAV3 GSTA5 ADGRF4 CDC42EP3 GCLM CYP1A1 SCNN1A SRXN1 NRG1 PMP2 GSTM5 MFGE8 CES1 POU5F1 SLC26A2 ABHD2 PRRG4 GPR153 SERTAD2 STOM NR1C1 PPP1R14C CAVIN2 PTGES3 PLK2 DNAJC15 KTN1 S100P CPEB4 JUNB UGT1A1 NCOA1 HEL-S-22 BAAT B3GNT5 CYP2A6 ACKR3 STAT3 UGT2B4 UGT2B7 SLC39A2 NR1H3 SLC39A1 NR1C2 SLC39A3 CYP7A1 CYP4A11 CYP3A7 ADH7 SERPINB2 PTGR1 ACOX1 EHHADH UGT1A4 SLC7A5 IL2 UGT1A3 SQSTM1 UGT1A9 UGT1A7 DBI IFNG IL12A CYP8B1 AIP SMARCA1 GSTA4 GSTA3 HEL-S-10 NR3C1 FGD4 AHRR SLC6A19 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260910%WP5093%HOMO SAPIENS Opioid receptor pathways RPLP2 RELA ARC DKFZp762B153 SQSTM1 BDNF TUBB ADCY8 NOS2 TLR4 NEU2 OPRM1 HDAC1 TNF RGS4 PRKCE MBP RAC1 HMOX1 JUP ALDH9A1 HEL-S-72p ADCY1 GATA4 CACNA1B LUPUS THERAPIES%WIKIPATHWAYS_20260910%WP5560%HOMO SAPIENS Lupus therapies IL17F CD80 CD22 IL17A HEL-S-62p C1QC CD40LG C4A CD19 IFNG C1QB IL12A C1QA CD40 IL25 IL12B C4B_2 MS4A1 IL23A IL6R IL17D IL17C TNLG7A IL17B IL6 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260910%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease STAT4 IL17F IL12RB1 IL17A TNF IL23A STAT5B CSF2 IFNG TLR4 IL12B IL22 STAT1 STAT3 RORC TYK2 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260910%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED27 TBP TAF8 MED23 TAF13 H4C9 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260910%WP4565%HOMO SAPIENS Neural crest cell migration in cancer NTRK2 JUN PIK3CD EPHB6 TWIST1 PAK1 EPHB1 EPHB3 BDNF FOS PAK6 PAK4 EPHB2 AKT3 MMP2 NGFR TRIO EPHB4 MMP9 ARHA TIAM1 RAC1 F2RL2 PIK3R4 PIK3R3 PIK3R5 SORT1 STAT3 KIDINS220 ARF1 CDH11 GDNF SIGNALING%WIKIPATHWAYS_20260910%WP5143%HOMO SAPIENS GDNF signaling 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome PEX10 TGFB1 ISG15 PHKG2 C1QTNF12 TRAF2 VTN SKI GNB1 ATAD3A ELAVL1 SMAD2 GRIK2 PANK4 INTS11 INTS13 INTS14 TRAF5 INTS10 CALML6 GDE1 TMEM52 UBE2J2 NOC2L METTL14 SDF4 INTS4 PLEKHN1 CCNL2 SAMD11 TNLG2B MUSK COMMD1 SSU72 HEL-S-72p PEX2 ATAD3C GLTPD1 ACAP3 RER1 SCNN1D PEX5 AGRN MXRA8 VWA1 BTLA B3GALT6 AURKAIP1 TNLG2A VEGFA MMP23B ARF6 PERM1 KLHL17 MEPCE LRP4 PUSL1 TAS1R3 HES4 OR4F5 OR4F3 CDK11A CFAP74 MIB2 TNFRSF4 RNF223 MORN1 TMEM278 NADK CD160 FNDC10 ANKRD65 TNFRSF14 PEX12 INTS9 MRPL20 SLC35E2B C1orf159 TNFRSF18 IFIH1 TRIM25 IFIT1 DKK3 DVL1 PRKCZ PARD6B SMAD4 RBX1 MCM2 PLCH2 HES5 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260910%WP4725%HOMO SAPIENS Sphingolipid metabolism overview SPTLC1 SGMS2 CERS3 SGPP1 DEGS1 CERS6 KDSR CERK LASS1 CERS2 SGMS1 DEGS2 SGPP2 SPHK2 SPHK1 SGPL1 PLPP3 GBA2 SPTLC2 PLPP2 UGT8 UGCG SMPD1 PLPP1 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260910%WP4191%HOMO SAPIENS Caloric restriction and aging SIRT1 IGF1 PRKAB2 PPARGC1A NAMPT MTOR TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260910%WP5300%HOMO SAPIENS TROP2 regulatory signaling CCNE1 TLN1 NFKB1 IGF2R SRC JUN ABCC1 BCL2 TACSTD2 IGF2 PAK4 CDK4 CDK2 CCND1 BAX IGF1R HEL113 MDK CLDN7 ITGB1 PRKCA RB1 PIK3R1 CLDN1 CDKN1B RAC1 PECAM1 NOTCH1 CDKN2A PTEN IGF1 CHEK1 ACVRL1 PSEN2 STAT1 EGFR METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260910%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX15 ALOX12 PTGS2 FADS2 ALOX5 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260910%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling RIPK1 FADD TRAF1 RELA NFKB1 IKBKB NFKB2 JUN TRAF2 CHUK NFKBIA RAF1 MAP3K14 MAPK9 BIRC2 BIRC3 TRIM63 GSK3B TNFRSF12A MAPK14 TNFSF12 HDAC1 TNF TRAF5 NFKBIB MAPK1 RAC1 MAP3K7 MAPK3 CASP3 RELB TRAF3 MAPK8 CASP8 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer SIAH1 PMAIP1 TNFRSF10B SESN3 BBC3 CASP9 TP53AIP1 ZMAT3 PERP PTEN CHEK2 EI24 CASP3 SHISA5 CYS1 MDM2 BAX APAF1 DDB2 ATM CASP8 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260910%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer TCF7L2 TCF7L1 MSH2 TGFB1 CSNK1A1 MSH3 APC CSNK1A1L TGFBR2 BIRC5 FOS BRAF MAPK9 AKT3 RALA GSK3B SMAD2 EXOC2 AXIN2 MAPK10 ARHA REL CDKN1A MAPK1 RAC1 BCL2L11 BBC3 CASP9 NTN1 TGFBR1 MAPK3 CASP3 MAP2K1 BAD DDB2 PMAIP1 GADD45B GADD45A PTGS2 JUN APPL1 GADD45G BCL2 RAF1 TBK1 CCND1 BAX MYC CYCS ARAF DCC RALB RAC3 POLK APC2 AXIN1 LEF1 SMAD4 MSH6 MAPK8 BAK1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260910%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification FGFR3 SOX6 NOTCH1 ALPL PLAT MGP GJA5 JAG2 DLL3 LPAR1 DLL4 CALU ITGA1 VEGFA COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP558%HOMO SAPIENS Complement and coagulation cascades F2 HEL-S-78p F7 F2R SERPING1 KLKB1 SERPINA1 VWF KNG1 PROS1 CLU C8G C3AR1 HEL-S-62p CR2 CR1 SERPINF2 PLAUR C1QC F3 F5 F8 F9 MASP2 MASP1 CD46 CFB CFD C1QB C1QA CPB2 C1S CFH SERPINC1 CFI C5AR1 C4B_2 THBD TFPI LMAN1 C6 C7 C9 CD55 F10 SERPIND1 PROC F13B BDKRB1 PLAT PLG CLTC FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260910%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling FSHR MAPK14 RHEB RPS6KB2 H3-4 PRKCA FOXO1 EIF4EBP1 SRC MAPK1 TSC2 APPL1 MAPK3 RAF1 FSHB SGK1 CGA MTOR CREB1 RPS6 RPS6KB1 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260910%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260910%WP5133%HOMO SAPIENS Non classical role of vitamin D AGTR1 AGTR2 CYP27B1 CYP2R1 REN ACE2 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260910%WP4297%HOMO SAPIENS Thiamine metabolic pathways HEL107 BCKDK SLC19A3 DKFZp667O1614 PDHA1 SLC19A2 OGDH TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260910%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer GRB2 SOS1 TSC1 AKT1S1 MAPKAP1 NRAS TSC2 HRAS RAF1 BRAF AKT3 MTOR RICTOR IRS1 EIF4EBP1 PIK3R1 ARAF INPP4B MAPK1 DEPTOR MAPK3 PTEN MAP2K1 RPTOR MAP2K2 SOS2 PARP2 MLST8 RPS6KB1 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260910%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia TRPC3 ATP2B2 RYR3 PLCB3 GNA14 PLCB4 GNA15 GRIA2 PLCB1 PLCB2 CA8 GNA11 GRIA3 CACNA1A HOMER3 GRIA4 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260910%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 CD27 CD80 CD3G CD3E CD3D SPN IL2 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260910%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer SYTL2 EXPH5 RPH3A MADD RAB27A RAB27B SYTL1 MYRIP SYTL5 UNC13D MLPH TBC1D10A NEPHROGENESIS%WIKIPATHWAYS_20260910%WP5052%HOMO SAPIENS Nephrogenesis FOXD1 MEIS1 OSR1 GREB1L PAX2 FGF20 ALDH1A2 NOTCH2 WNT9B BMP7 WNT4 WNT3A TCF21 SIX2 RSPO3 FGF8 RSPO1 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260910%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1C2 NR1i1 NPC1L1 SCARB1 NR1i2 CYP2C9 CD36 NR1C1 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260910%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 MORC3 ELL EZH1 STK38 TRIM35 RBBP7 THRAP3 SUZ12 BCLAF1 JARID2 SETX RBBP4 EZH2 AEBP2 EED DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260910%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte SMAD9 CEBPA CEBPB SLC7A10 HOXC8 HSPB7 EBF3 HOXC9 MPZL2 DGIC CEBPG LEP ZNF423 PPARGC1B ZIC1 CIDEA DKFZp781O1323 BMP7 PPARG BMP4 SMAD1 BMP2 PRDM16 PPARGC1A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260910%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP4A22 CYP2C18 EPHX2 CYP4F2 PPARG CYP4A11 CYP4F12 NR1C1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260910%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A DRD1 DRD2 CALM1 DRD4 GNAI1 ACTG1 RAP1A PS1TP5BP1 RAF1 ADCY8 GNAS PPP1CC GRIA3 GRIA4 HEL-S-80p GRIN1 PRKCB PRKCA ARAF CAMK4 MAPK1 ACTG2 MAPK3 MAP2K1 PRKACG ADCY1 MAP2K2 GRIA2 GJB1 PPP1R1A CREB1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260910%WP4150%HOMO SAPIENS Wnt signaling in kidney disease FZD9 FZD8 WNT2B WNT9B INVS FZD1 WNT16 FZD3 LRP5 WNT3A WNT7A WNT3 LRP6 MAPK9 WNT7B WNT5B MAPK10 ARHA DVL1 DVL2 DVL3 WNT1 WNT4 NPHP3 WNT10B WNT10A FZD2 FZD5 MAPK8 FZD4 FZD7 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260910%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis CSN3 EIF4G1 PRKAB2 PRKAA2 EIF4E EEF2K CSN1S1 PRKAG1 PRKAG2 TSC2 PRKAB1 EEF2 PRKAG3 RPTOR EIF4A2 MLST8 PRKAA1 MTOR CSN2 RPS6KB1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260910%WP2361%HOMO SAPIENS Gastric cancer network 1 APC S100P NUP107 INO80D NOTCH1 HCTP4 GATD3 AURKA H4C9 SMOC2 ESM1 RUVBL1 MYBL2 ECT2 E2F7 KIF20B UBE2C TOP2A H3F3B ACTL6A CENPF CEP192 LIN9 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260910%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F2 NQO1 F7 F10 PROS1 VKORC1 PROC GGCX PROZ F9 AIFM2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260910%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy TGFB1 RASGRF1 NFKB1 STAT3 PPP3R1 MYEF2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260910%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS2 ALAS1 FECH UROD UROS HMBS CPOX SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260910%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization TGFB1 IL12RB1 CCR1 IFNGR1 IL18R1 CD40LG CCL4 CCL3 IL2 IL4 CXCR3 CSF2 IFNG IL5 IL12A IL12B CCR3 CXCR4 CCR2 CCR7 CCR5 CCR4 IFNGR2 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence FADS1 EPHX2 PTGES ALOX15 ELOVL2 ALOX12 GPX1 CYP4F8 LTC4S PTGS2 HEL-S-53e PTGS1 DECR1 ALOX5 PTGIS DPEP2 NAT2 SIRT1 ALOX15B PRXL2B ALOX5AP AKR1B1 PTGES3 SLCO2A1 ELOVL5 MAPK11 RB1 CDKN1A HEL-S-22 ALOXE3 HEL-S-298 HPGD FADS2 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260910%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function CAMK2A GRIN2B PPP1R1B DRD1 DRD2 ADCY3 ADCY6 ADCY5 HEL-S-7a ADORA2A ADCY8 ADCY9 PDE5A PDE1A GRIN1 PDE7A PDE1B PDE4D PDE3B PDE4B PDE4A PDE8A PDE1C GUCY1B1 PRKG1 CHRNA7 ADCY1 PDE6D GUCY1A2 PDE11A PDE6C PDE6A PDE2A PDE7B PDE6H PDE10A PDE12 PDE3A PDE9A PDE6G CREB1 TNF ALPHA SIGNALING%WIKIPATHWAYS_20260910%WP231%HOMO SAPIENS TNF alpha signaling TRADD RIPK1 FADD TRAF1 TNFRSF1A NFKB1 IKBKB NFKB2 TRAF2 CHUK NFKBIA TANK PYGL MAP3K8 MAP3K7IP1 PIG59 TAB3 MAP3K14 MAPK9 DIABLO PLK1 REL MAPK1 RAC1 MAP3K7 TNFRSF1B CASP9 MAPK3 PSMD2 KSR2 MAP2K4 CASP3 MAP4K2 CREBBP MADD BAD APAF1 GRB2 SOS1 BCL2L1 KSR1 RFFL MAP2K6 MAP2K3 OTUD7B JUN MAP3K1 TXN NRAS HRAS RAF1 TNFAIP3 TBK1 CDC37 BAX SMPD2 CYBA BIRC2 SKP1 BIRC3 CSNK2A1 BTRC NFKBIE TNF FBXW11 NFKBIB IKBKG MAP3K5 PRKCZ PPP2CA PTPRCAP MAPK8 CASP8 NSMAF RIPK3 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260910%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors LAMC1 COL1A2 COL4A2 COL4A1 COL6A1 SDC2 THBS1 LAMA4 THBS2 COL5A3 COL5A2 XB ITGB6 COL3A1 LAMB2 ITGA1 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260910%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary FSHR NFKB1 PIK3CD NRAS HRAS DKFZp686L0365 RAF1 BMP15 PLCB3 KISS1 PLCB4 STAR HSD3B1 PLCB1 PLCB2 MMP9 PRKCH PRKCB PRKCE PRKCA PRKCQ MAPK1 MAPK3 MAP2K1 MAP2K2 CYP11A1 AMH KISS1R FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260910%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling LY96 HEL-S-78p TICAM1 IRAK4 RELA NFKB1 IKBKB TRAF6 SRC CCL2 CHUK CXCL3 TICAM2 IRAK1 NOS2 TIRAP TLR4 IRAK2 IL12B TLR3 MYD88 IFNB1 IRF3 ITGAM TNF ARHA REL LBP FCER1G IKBKG PLAT SYK PLG TYROBP FGA IL6 CD14