TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 UBE2I XPO1 SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PTPN11 PRKCA PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE DAB2IP PRKCA RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 CALM3;CALM1 EIF3A PTPN11 IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB FRS2 ARHGAP35 PTPN11 IGF1R KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 CENPA SMC4 NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN POMC MC4R APH1A NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 WNT7A FZD8 KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 CALM3;CALM1 KIF5B PTPN11 CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 ELF2 PTPN11 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 ITGA6 LAMC2 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 PPP2R5A WWP1 NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 FRS2 PTPN11 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 MAPK8 APH1A CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FRS2 FOS PTPN11 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 RHO SAG CNGA1 PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B SNAP25 RIMS1 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 NFATC4 MAPK10 PTPN11 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB CXCR2 PRKCA RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 C4BPB SOD1 CYP2C18-1 SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 PRKCA ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 EIF2A WWP1 PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 NFATC1 XPO1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB CALM3;CALM1 PTPN11 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 MST1R PRKCA GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 CENPA AURKAIP1 MDM2-2 GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 KREMEN2 APH1A CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL SHH NQO1 WWP1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A CALM3;CALM1 PTPN11 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 POMC MAPK8 SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD MALT1 ERC1 TNFAIP3 PRKCA RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway TKT HK2 HK1 RPIA GPI HKDC1 TALDO1 PGD ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK2 HK1 GALE GALT ALDOC ALDOB HKDC1 ALDOA KHK P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway MAPK14 MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 EIF4E MEF2D MAP3K7 MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway VEGFA HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 AKT3 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK PDPK1 IL11RA IL15 IL13 IL18 FOS IL1A IL23A IL3RA SOS1 IL6ST SOS2 IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 MAPK6 ELK1 IL12RB1 IL12RB2 STAT5A STAT5B MKNK1 STAT1 MKNK2 IL10RB STAT2 IL10RA STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL9 IL2RB SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 MAPK3 NOS3 BRAF FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis PPOX EARS2 COX10 ALAD FECH EPRS1 QARS1 UROD HMBS RSAD1 CPOX NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CHRNA3 KCNK9 CHRNA5 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 SLC18A2 DRD4 CHRNB2 CHRNB4 CHRNB3 PPP1CA PPP1R1B GNB1 KCNK3 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system TPTEP2-CSNK1E;CSNK1E CSNK1D CLOCK ARNTL PER2 PER1 CRY2 CRY1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1-1 SQLE FDPS MVK GGPS1 IDI2 PMVK PDSS1 MVD HMGCR LSS FDFT1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIA1 GRIA2 SNAP25 STX19 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 SHANK3 VAMP2 SHANK1 VAMP3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 CDKN1A MAPK13 MAPK11 PIK3CD PIK3CB PIK3C2A AKT2 PIK3CG PIK3C2B AKT3 AKT1 HRAS PDPK1 PIK3CA CCNE1 PIK3C3 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 TP63 SIAH1 PIK3R3 TPTE;TPTE2 PIK3R2 RBL1 PIK3R1 CDK2 CCNG1 CTNNB1 NRAS KRAS ATM TP53 TP73 ATR THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRM1 PRKACB-1 GRM5 PLCB4 GRIK5 PRKAR1B PRKAR1A GNAQ GNA11 GRINA GRIK1 GRIN2A GRIN2C GRIN2B GRIN2D GRIN1 HOMER1 PRKACA-1 GRIN3A ITPR1 PRKCB PRKX OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK14 MAPK12 MAPK13 PLA2G4A MAPK11 MAP2K3 JUN MAX TXN MAPK9 MAPK8 DDIT3 BCL2 ELK1 MYC EEF2K STAT1 MKNK1 MKNK2 MAP2K6 MAP2K4 MEF2C 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway PRKACB-1 GNAI3 ADCY7 GNAI2 KCNK9 GNG10 GNG5 PRKAR2B GNG4 PRKAR2A ADCY2 GNG8 HTR1E GNAI1 HTR1F HTR1D PRKACA-1 HTR1A GNG2 HTR1B GNAO1 GNB2 GNB4 GNB3 GNB5 GNB1 KCNK3 PRKX OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNA11 GNG10 GNG5 GNG4 GNG8 PRKCG PRKCI GNG2 PRKCH PRKCB GNB2 GNB4 PRKCE GNB3 PRKCD GNB5 OXTR GNA14 PRKCA PLCZ1 PLCE1 PLCL1 PLCB3 GNB1 PRKCQ PLCB1 PLCD4 PLCB2 PLCD1 PRKCZ PLCG2 PLCG1 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB2 GNB4 GNB3 GNB5 GNB1 HTR4 GNAL ADCY7 GNG10 GNG5 GNG4 ADCY2 GNG8 GNG2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKACB-1 PRKAR1B PRKAR1A GNAI3 ADCY7 GNG5 PRKAR2B GNG4 PRKAR2A ADCY2 GNG8 GNAI1 CACNA1G PRKACA-1 GNAO1 GNB2 GNB4 GNB3 GNB1 ADCY4 CACNA1B CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 GABBR2 GABBR1 ADCY9 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 UBE2G2 UBE2D3;UBE2D2 UBE2D3-1 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K ATG7 UBE2B UBE2D4 UBA7 UBA6 UBE2C ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway GSK3B APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 NOTCH3 NOTCH1 LRP1 CTNNB1 NOTCH4 LEF1 WNT8A PSEN2 LRP5 WNT8B LRP4 LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTB-1 NECTIN1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH1L1 MAOB MAOA ALDH1L2 ALDH3A2 ALDH4A1 ALDH1A3 IL4I1 ALDH3A1 ALDH3B2;ALDH3B1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2-2 TP53 MDM4 TP73 TP63 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PPCS DCAKD PANK4 PANK3 PANK1 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation PPP3CA PPP3CB BLNK VAV3 SYK NFKBIL1 VAV1 VAV2 IKBKB BTK ITPR2 ITPR3 CD79B CD79A CD19 LYN MAP3K2 MAP3K3 CALM3;CALM1 NFKBIA MAPK10 PTPRC PTPN6 GRB2 CD22 CHUK FOS SOS1 SOS2 ITPR1 MAPK14 MAPK12 MAPK13 MAPK11 JUN ARAF MAPK9 MAPK8 PIK3CD PIK3CB PIK3CG RAC1 HRAS PRKCB PRKCD PIK3CA RAF1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 MAPK3 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation PRKAG1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 EIF4EBP1 PPP2CB;PPP2CA TP63 AKT2 AKT3 AKT1 TP53 TP73 IGBP1 PRKAA1 PRKAB2 PRKAA2 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis DAGLA PLCB3 LIPH LPL PLCB1 PLA1A PLCB2 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism PMM2 MPI GMPPB PMM1 GMDS GMPPA MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation TXN AKT2 HIF1A AKT3 EGLN1 CREBBP AKT1 EGLN3 EGLN2 RORC ARNT MTOR TXN2 VHL THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism TPK1 THTPA TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2A1 GTF2A2 GTF2B TAF9 PRKAR1B TTF2 PRKAR1A TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C CREB3L1 POLR2C CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 PRKAR2B POLR2L TBP PRKAR2A BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 CREBBP OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNB2 GNB4 GNB3 GNB5 OPRD1 GNB1 POMC GNAI3 ADCY7 GNAI2 GNG10 GNG5 GNG4 ADCY2 GNG8 GNAI1 GNG2 GNAO1 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled ADCY3 ADCY10 ITPR2 ITPR3 AKT2 AKT3 ITPR1 PRKACB-1 PLCB4 PRKAR1B PRKAR1A GNAQ GNA11 ARAF ADCY7 PRKAR2B AKT1 PRKAR2A ADCY2 PRKCG PRKACA-1 PRKCI PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA GNA14 PLCB3 PRKCQ PLCB1 RAF1 PLCB2 GNAL ADCY4 ADCY1 ADCY8 GUCY1B1 PRKCZ ADCY6 EDNRA ADCY5 EDNRB MAP2K2;MAP2K1 PRKG2 PRKG1 MAPK1 GUCY1A2 ADCY9 EDN1 GUCY1A1 MAPK3 EDN2 NOS3 EDN3 GNAS-1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis GCH1 FPGS TYMS DHFR2;DHFR 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCB4 HTR2B HTR2A GNAQ GNA11 GNG10 GNG5 GNG4 GNG8 PRKCG PRKCI GNG2 PRKCH PRKCB GNB2 GNB4 PRKCE GNB3 PRKCD GNB5 GNA14 PRKCA PLCZ1 PLCE1 PLCL1 PLCB3 GNB1 PRKCQ PLCB1 PLCD4 PLCB2 PLCD1 PRKCZ PLCG2 PLCG1 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway COL3A1 LIMS2 BCAR1 MAP3K2 MAP3K3 MAPK10 MAP3K4 MAP2K4 MAPK13 MAP2K3 ARAF MAPK9 MAPK8 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 HRAS PIK3CA PIK3C3 RAF1 PXN PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK3 BRAF PTK2 COL16A1 COL12A1 ITGA2B ARPC5L CRKL MAP3K5 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 ELMO1 COL8A2 COL4A6 ACTG1 ELMO2 COL8A1 COL4A5 TLN1 VCL COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 PARVA SOS1 PARVB ARPC5 SOS2 ARHGAP26 COL1A2 LIMS4;LIMS1 ARPC2 COL5A1 ARPC3 ACTBL2 COL5A3 ITGA10 MAPK6 ITGA11 COL5A2 COL20A1 COL9A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ARPC1A ITGB2 ILK LAMC2 LAMC1 SHC1-1 ITGAE RND2 ITGAL RND3 RND1 ITGAX COL10A1 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 RAPGEF1 ITGA8 FLNA ITGA7 ACTB-1 COL6A3 ITGA6 ITGA5 CRK DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 LAMA1 SRC LAMA4 COL11A1 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MICALL1 PTK2B FLNB FYN CSK LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARHGAP42 OPHN1 GRAP2 PDGFRB VAV3 PDGFRA PDGFRL ERF VAV1 ERG VAV2 SHC3 PDGFB ITPR2 PDGFA ITPR3 ARHGAP15 ARHGAP12 SRGAP3 SRGAP1 FLI1 MAP3K2 FEV GRAP ARHGAP9 GSK3A MAPK10 ARHGAP5 ARHGAP6 GRB2 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA JAK1 NCK1 GAB1 GAB2 ETV3 RPS6KB1 ELF1 ELF2 RPS6KB2 ELF3 ELF4 ELF5 RASA1 RASA2 RPS6KC1 SPDEF PIK3R5 MYCBP-1 ELP1 SRF USF2 RAB11B ELK1 NIN RPS6KA4 PKN2 RPS6KA5 MKNK1 MKNK2 MAP3K4 ITPR1 MAPKAPK2 JUN ARAF ARHGAP1 MAPK8 PIK3CD PIK3CB ETS1 PIK3CG ARHGAP8;PRR5-ARHGAP8 HRAS PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 RPS6KA3 RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 JAK3 CHUK PDPK1 FOS SOS1 SOS2 ARHGAP26 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 SHC1-1 ARHGAP10 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A SLC5A7 MYH1 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 MYH11 CHRNA3 MYH10 MYH7B CHRNA5 MYO10 MYO5A CHRNA4 MYO19 CHRNA6 MYO1G;MYO1D MYO9A MYO16 MYO1E MYO1B SLC6A8 MYO1C MYO1A MYO15A MYO5B MYO5C ACTB-1 MYO1F CHRNB2 CHRNB4 CHRNB3 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT6 JAK1 STAT5A STAT5B STAT1 JAK3 STAT3 JAK2 STAT4 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 VASP PIK3CA NTN1 NTN3 ABLIM1 NTNG1 NTNG2 DCC UNC5B PIK3R5 NFATC3 NFATC2 UNC5C PIK3R3 UNC5D PIK3R2 NFATC4 NTN4 PIK3R1 RHOU CDC42 PLCG2 PLCG1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 SLC18A1 SLC6A2 SLC6A3 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MAT1A MTR-1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 PFN3 TUBB3;TUBB6 ROCK1 ROCK2 ACTC1;ACTG2 PAK1 PAK3 PAK2 PAK5 ACTG1 PAK4 LIMK1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 ACTA2 ACTA1 ARPC2 ACTBL2 ARPC3 MYH1 MYH3 ARPC1B MYO3B ARPC1A MYO3A MYH8 MYH9 MYH6 MYH7 MYH13 MYH14 MYH11 MYH10 MYH7B RHOC RAC1 ACTB-1 RHOU CDC42 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS2 MAP2K3 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 IRS4 IGF1R INS;INS-IGF2 INSR INSRR FOS IGF2 RPS6KB1 IGF1 IGF2R RPS6KB2 SOS1 SOS2 RASA1 RAF1 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 MAPK3 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway JAK1 STAT1 IFNG IFNGR1 IFNGR2 JAK2 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides NME3 UPRT UPP1 UCKL1 ADAT2 UCK1 NME4-1 NME2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GRIA1 GRIA2 ADCY10 SNAP25 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 GRIN2A SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 VAMP2 VAMP3 GRM4 GRM7 GRM6 GRM8 CACNB1 STX1A CACNA1E VTI1A SLC17A7 PRKX GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A GNAI3 GNAI2 GNG10 GNG5 PRKAR2B GNG4 PRKAR2A GNG8 GNAI1 PRKACA-1 GNB2 GNB4 GNB3 GNB5 GNB1 CACNA1B CACNA1A APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway IKBKB MAP3K5 AKT2 AKT3 NFKBIA MAPK10 CHUK FOS IGF2R ATF1 TP53 MAP2K4 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 CASP10 CASP3 TNFSF10 GZMH;GZMB-1 MAP2K3 MAP4K2 DAXX JUN ENDOG APAF1 TRAF2 MAPK9 TNFRSF1B MAPK8 PIK3CD TNFRSF1A PIK3CB GZMH-1 BCL2 MADD LTA PIK3CG LTB TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP9 ATF6 ATF3 JDP2 AKT1 BIRC2 ATF4 BIRC3 ATF6B PRKCG CREM XIAP PRKCH RELA PRKCB RELB CYCS-1 BCL2L11 PRKCE RIPK1 PRKCD BAK1 FADD PRKCA MAP2K7 PIK3CA MAP4K3 MAP4K4 MAP3K1 CRADD PRKCQ BIK EIF2AK2 DIABLO-1 EIF2S1 NFKB1 NFKB2 ATF7;ATF7-NPFF PRKRA REL BAX FAS MAP3K14 BCL2L1 MAPK1 MAPK3 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway GSK3B RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 PAK1 AKT3 PAK3 PAK2 GSK3A MAPK10 GRB2 PDPK1 SOS1 SOS2 SRF ELK1 STAT1 KRAS STAT3 MAP3K4 MAP2K6 MAP2K4 ATF2 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 MAP2K3 JUN ARAF MAPK9 MAPK8 PIK3CD PIK3CB ETS1 PIK3CG RHOC RHOA AKT1 RHOB RAC3 RAC1 HRAS MAP2K7 PIK3CA MAP3K1 PIK3C3 RAF1 CDC42 NRAS MAP3K7CL MAP2K2;MAP2K1 RALA-1 TIAM1 MAPK1 EXOC2 RALB PLD1 MAPK3 PLD2 RALGDS BRAF RGL1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin ARRB1 ARRB2 GRK3 GRK2 EGR1 AGT GNAQ AGTR1 ITPR2 ITPR3 GNG10 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKCA PLCB3 GNB1 PLCB1 RAF1 PLCB2 ELK1 MAP2K2;MAP2K1 MAPK1 MAPK3 ITPR1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CDKN1A HDAC1 CCNB1 WRN SUMO1 SIN3A CHEK2 SUMO3 TRAF2 SUMO2 HMGB1-1 SFN AKT2 MTA2 EP300 GTSE1 CDKN2D GADD45B AKT3 CDKN2A GADD45A CDC25C AKT1 SIRT1 PML GADD45G KAT2B KAT6B CDK1 PDPK1 PIK3CA CCNE1 PTEN TP63 TPTE;TPTE2 CDK2 ATM MDM2-2 CREBBP TP53 MDM4 TP73 ATR THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 SNAP29 VAMP8 TRH VAMP1 TSHB TRHR VAMP2 CACNB2 CACNB3 VAMP3 CACNB4 STX3 CGA CACNB1 CACNA1E PLCB4 GNAQ GNA11 GNG10 GNG5 GNG4 GNG8 PRKCG PRKCI PRKCH GNG2 PRKCB GNB2 GNB4 PRKCE GNB3 PRKCD GNB5 PRKCA GNA14 PLCZ1 PLCE1 PLCL1 PLCB3 PRKCQ PLCB1 GNB1 PLCD4 PLCB2 PLCD1 CACNA1B CACNA1A PRKCZ PLCG2 PLCG1 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CTNNB1 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 ACTC1;ACTG2 WNT2B FZD10 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 ACTB-1 UNTITLED%PANTHER PATHWAY%P06664 untitled SKIL TGIF1-1 RELA PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle CS FH PDHA1 MDH1 OGDH SUCLG1 SDHC ACO2 PDK2 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1C ATP5F1B ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1-2 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYSL2 ABAT DPYS DPYSL3 DPYD ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade IGF1R TSC2 INS;INS-IGF2 GSK3B INSR FOXO1-1 TSC1 INSRR IGF2 IGF1 IGF2R PIK3CA IRS1 IRS2 FOXO3 PTEN TPTE;TPTE2 GSK3A MDM2-2 MDM4 PDPK1 IRS4 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB2 GNB4 GNB3 ADRB3 GNB5 GNB1 GNAL ADCY7 GNG10 GNG5 GNG4 ADCY2 GNG8 GNG2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism GDA AMPD3 XDH NT5E METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNB2 GNB4 GNB3 GNB5 GNA14 GNAQ CRHR1 GNA11 CRHR2 CRH GNB1 POMC GNAL GNG10 GNG5 GNG4 GNG8 GNG2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP MAPK10 KAT5 PSENEN CACNB2 ADAM17 PKN3 BACE1 CACNA1D MAPK7 CACNA1F BACE2 KLC1 KLC4 KLC3 KLC2 MAPK6 CACNA1S MAPK4 PKN2 APBA1 PKN1 APBA3 APBA2 CACNB1 PSEN2 MAPK15 PSEN1 MAPK14 MAPK12 NCSTN MAPK13 MAPK11 APH1B CHRNA7;CHRFAM7A MAPK9 MAPK8 CACNA1C PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA PRKCQ PRKCZ MAPK1 MAPK3 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo NTN1 NTN3 NTNG1 NTNG2 DCC SRGAP1 NTN4 RHOC CDC42 CXCR4 ROBO1 RAC1 CXCL12 ABL1 SLIT1 SLIT3 SLIT2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CPS1 NME3 CAD CTPS2 CTPS1 DSCAML1 DHODH NME1 NME4-1 NME2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway MAP3K5 SHC3 AKT2 MAP3K2 MAP3K3 AKT3 GRAP MAPK10 RASA4;RASA4B GAB1 GAB2 RRAS SOS1 SOS2 RASA1 RASA2 PIK3R5 STAT4 STAT6 STAT5A STAT5B STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ERBB4 PEBP1 PEBP4 MAP2K3 RRAS2 GAB3 MRAS PHLDB2 ARAF RASAL2 MAPK9 EGFR MAPK8 PIK3CD ERBB3 PIK3CB ERBB2 PIK3C2A SPRY4 DAB2IP PIK3CG SPRY3 PIK3C2B NF1 SPRY2 SPRY1 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA MAP2K7 PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 SHC2 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade PLAT PLG MMP9 MMP13 PLAU FGB FGA SERPINB2 MMP1 SERPINF2 MMP3 FGG SERPINE1 PLAUR PNAT%PANTHER PATHWAY%P05912 PNAT PRKACB-1 SNAP25 SNAP23 GNAI3 ADCY7 GNAI2 KCNK9 SNAP29 EPB41 PRKAR2B GNG4 PRKAR2A ADCY2 GNG8 GNAI1 VAMP8 PRKACA-1 VAMP1 EPB41L1 EPB41L2 GNB2 VAMP2 FLNA GNB4 DRD2 GNB3 VAMP3 SLC18A2 STX3 DRD4 GNAZ PPP1CC DRD1 DRD5 PPP1CA PPP1R1B GNB1 KCNK3 SLC6A3 PRKX HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway GLI3 CREBBP SHH SMO FBXW11 STK36 PTCH1 GLI1 BTRC MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway PRKACB-1 ADCY10 PRKAR1B PRKAR1A GNAI3 GNAI2 GNG10 GNG5 PRKAR2B GNG4 PRKAR2A GNG8 GNAI1 PRKACA-1 SLC6A8 GNAO1 GNB2 GNB4 GNB3 GNB5 GNB1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 KCNJ3 KCNJ9 SLC18A3 SLC5A7 PRKX N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 NPL GFPT2 GFPT1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway AMHR2 CITED1 SKIL CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 GDF10 SMAD1 GDF11 SMAD4 TGFB2 JUND SMURF2 GDF15 TGFB3 MAPK10 SMURF1 GDF2 BMP8B GDF1 SMAD9 INHBB GDF3 INHBA GDF6 SMAD6 BMP7 RRAS GDF5 INHBC SMAD5 ACVR2B ACVR2A BMP6 SMAD7 GDF7 INHBE BMP5 FOSL1 SKI BMP4 GDF9 BMP3 BMP2 BMP1 GDNF TLL2 TLL1 BMPR1B CREBBP NODAL BMPR1A MAP3K7 DCP1B ATF2 MAPK14 MAPK12 MAPK13 MAPK11 JUN TAB1 MAPK9 MAPK8 EP300 HRAS NRAS MAP3K7CL MAPK1 ACVRL1 MAPK3 BMP10 BMPR2 MSTN BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F10 GP1BB F12 F2R GP1BA F2 GP5 F3 GP9 ITGA2B PROCR F7 F8 F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PROS1 TFPI KNG1 THBD VWF PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway GSK3B GNAQ IRS1 GNA11 PIK3CB PTGER1 GNAI3 AKT2 FOXO4 GNAI2 GNGT1 YWHAZ CASP9 AKT3 AKT1 GNAI1 PDPK1 GNB2 GNB4 INSR FOXO1-1 GNB3 GNB5 RPS6KB1 GNA14 PIK3CA RPS6KB2 SOS1 SOS2 GNB1 FOXO3 PIK3R5 PIK3R3 PIK3R2 PIK3R1 GNAT2 NRAS NOS3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway GRM3 GRM2 CALM3;CALM1 GSK3A CREBBP GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A CREB3L3 CREB3L4 CREB3L1 CREB3L2 GNAI3 EP300 ADCY7 GNGT1 GNAI2 GNG10 CHRM3 GNG5 CHRM1 PRKAR2B CHRM5 GNG4 HTR6 PRKAR2A HTR7 GNG8 ADORA3 HTR1E ADORA1 HTR1F PHKA1 HTR1D PHKA2 HTR1A MTNR1A HTR1B MTNR1B ADRB1 GNB2 ADRB2 HRH1 HRH3 HRH2 CLTCL1 HRH4 PHKB PYGB CLTC CREB5 CLTB OPRD1 CLTA PYGM ADRA1D HTR4 PYGL GNAL ADRA1B ADRA1A ADCY4 GYS2 GYS1 GNRHR ADCY1 SSTR1 ADCY8 OPRM1 ADCY6 SSTR2 ADCY5 ADRA2C KCNJ3 SSTR3 ADRA2B ADCY9 SSTR4 SSTR5 CREB3 CREB1 ADORA2A ADORA2B OPRL1 ADCY3 PHKG1 GSK3B PHKG2 OPRK1 GPR50 HTR2B HTR5A HTR2A RAP1B RAP1A ADRB3 GRM4 GRM7 GRM6 GRM8 ADCY2 GNAI1 CREM PRKACA-1 GNG2 DRD2 DRD4 DRD1 DRD5 GNB1 CHRM2 CHRM4 KCNJ5 KCNJ6 KCNJ9 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway MAP3K6 FRS2 FRS3 FGFR4 FGFR3 FGFR2 MAP3K5 SHC3 FGFR1 AKT2 MAP3K2 MAP3K3 AKT3 GRAP MAPK10 PTPN6 RASA4;RASA4B SOS1 SOS2 RASA1 RASA2 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 PEBP1 MAP2K3 ARAF MAPK9 MAPK8 PIK3CD PIK3CB PIK3C2A SPRY4 PIK3CG SPRY3 PIK3C2B SPRY2 SPRY1 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA MAP2K7 PIK3CA PIK3C3 PRKCQ RAF1 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 OTC CAD ASL NAGS ASS1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 RHO GNG5 CNGA1 CALM3;CALM1 PDE6B GNG4 CNGA3 PDE6A GNG8 RGS9 RCVRN GNG13 CNGB3 CNGB1 GNG2 GNB2 GNB4 GNB5 GNB1 GNAT1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK14 MAPK12 MAPK9 MAPK8 SFN YWHAZ MAPK10 PRKN YWHAE YWHAB PPP1R8;STX12 PSMA7 PSMB10 PSMA8 PSMB7 YWHAQ PSMB3 CCNE1 PSMB1 NDUFV2 YWHAG SNCA MAPK7 YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 ELK1 CASK GPR37L1 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 MAPK1 PSMA3 PSMA4 MAPK15 PSMA1 SLC6A3 MAPK3 TH PLD2 CCNE2 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PLCB4 GNAQ GNA11 ITPR2 ITPR3 GRIN2A GNG10 CHRM3 GNG5 CHRM1 GNG4 GRIN2C GNG8 GRIN2B GRIN2D GRIN1 PRKCG PRKCI GRIN3A PRKCH PRKCB GNB2 GNB4 PRKCE GNB3 PRKCD GNB5 GNA14 PRKCA GNB1 PRKCQ PKN3 PKN2 PRKCZ PKN1 SLC18A3 SLC5A7 ITPR1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNB2 GNB4 GNB3 GNB5 OPRD1 GNB1 GNAI3 ADCY7 GNAI2 GNG10 GNG5 GNG4 ADCY2 GNG8 GNAI1 PDYN GNG2 PENK DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 PRIM1 RPA2 POLA1 POLD1 POLD2 DNA2 TOP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis DSCAML1 NME1 AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 RRM2B NME6 NME7 IMPDH2 ADSS1 ADSS2 RRM2-1 GART NME4-1 NME2 NME3 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA GC F13B HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway OPRL1 OPRK1 ITPR2 ITPR3 GRM3 GRM2 GNG13 DNAJC27 RAP1B RAP1A GRM4 GRM7 GRM6 GRM8 CACNA1E ITPR1 GRM1 GRM5 PLCB4 GNAQ GNA11 GNGT1 GNG10 CHRM3 GNG5 CHRM1 CHRM5 RHOA GNG4 GNG8 ADORA3 ADORA1 PRKCG PRKCI PRKCH GNG2 PRKCB GNAO1 GNB2 GNB4 PRKCE DRD2 GNB3 PRKCD DRD4 PRKCA GNA14 CLTCL1 DRD1 DRD5 CLTC PLCB3 CLTB PRKCQ PLCB1 OPRD1 GNB1 CLTA BDKRB2 BDKRB1 PLCB2 GARNL3 ARHGEF1 GPR45 RASGRP2 CHRM2 CACNA1B RASGRP1 CHRM4 CACNA1A RASGRP4 GNRHR RAP1GAP SSTR1 RASGRP3 OPRM1 PRKCZ SSTR2 SSTR3 SSTR4 SSTR5 ADORA2A ADORA2B ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PDGFRB PLA2G4D PDGFRA AXIN1 BIRC5 GRB14-1 DLL1 DLL3 PDGFB DLL4 PDGFA ANGPT1 DLK1 APC TEK GRAP NCK2 JAK1 NCK1 RASA1 HSPB1 CTNNB1 MAP2K4 MAPK14 F2R MAPKAPK3 MAPKAPK2 JUN PRR5 TGFB1I1 ARAF ARHGAP1 MAPK8 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA GSK3B FRS2 FRS3 CRKL FGFR1 AKT2 PAK1 AKT3 WNT2B PAK3 PAK2 RBPJ WNT5B FOS WNT5A SOS1 SOS2 RBPJL NOTCH2 NOTCH1 NOTCH4 STAT1 STAT3 SHC1-1 DVL1 DVL2 DVL3 WNT1 WNT2 FZD1 TCF7L2 WNT10B WNT10A FZD3 RHOC FZD2 RHOA FZD5 RHOB WNT7B WNT7A CRK MAP3K1 SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DOK2 DOK3 PLD1 EPHA3 PLD2 GRB7 TCF7 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis NME3 DTYMK DUT DSCAML1 ADAT2 RRM2-1 NME1 TYMS RRM1 NME4-1 RRM2B NME2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking RIMS1 SYT12 SNAP25 SYT11 STX2 SYT5 UNC13B UNC13C SYT3 SYT2 RAB3A SYT1 STX1A LOC102724488;SYT15 STXBP1 SYT7 UNC13D VAMP1 SYT6 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 ARRB2 BCAR1 EGR1 PPP3CA LYN CALM3;CALM1 NFKBIA MAPK10 GRB2 JAK2 CLU RPS6KB1 IER3 RHEB RPS6 PTGS2-2 EIF4EBP1 CETP ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 SRF RYR1 HSPB1 ELK1 RYR2 ELAVL1 RYR3 CD38 CTNNB1 GAST NOS1 CCKBR EIF4E AKT1S1 MEF2D PPARG HBEGF MAP2K6 GUCY2D MAP2K4 NR2C2 MEF2C ITPR1 AKAP1 HDAC7 BAD MAPK14 MEF2B;BORCS8-MEF2B PRKACB-1 PTPN11 CCK TPCN2 TPCN1 CAMK4 TRAF6 JUN ARAF MAPK9 MAPK8 BCL2 PIK3CB AKT1 RAC1 PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA PRKD2 PRKCQ PRKD1 RAF1 NFATC2 PXN PIK3R1 ADCY1 MAP2K2;MAP2K1 PRKG1 MAPK1 PLCG1 MAPK3 CREB1 BRAF PTK2 GSK3B CXCL8 IRS1 ELK4 RPS6KA3 ODC1 ROCK1 RPS6KA1 PAK1 CDH1 PDPK1 YWHAB FOXO1-1 FOS SOS1 FOXO3 MAPK7 ITGB1 STAT3 ATF2 SHC1-1 CASP3 ITGAV RHOA CREM MMP3 PRKACA-1 GNG2 SLC18A2 PLAU CRK GNB1 SRC BAX MAP3K14 CDC42 BCL2L1 PTK2B GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis HK2 HK1 TPI1 PKLR PGAM2 ENO1 BPGM ENO2 GAPDH-1 PFKL ALDOA PKM PGK1 PFKM GPI HKDC1 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway JAG2 JAG1 DLL3 DLL4 DLK1 RBPJL MAML1 NOTCH2 NCOR2 NOTCH3 NUMB NOTCH1 CIR1 NOTCH4 RBPJ GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 CSAD ABAT FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FASLG CASP7 CASP8 CASP10 CASP3 DAXX JUN MAP3K5 APAF1 MAPK9 MAPK8 CASP9 MAPK10 FAF1 CAPG LMNB2 LMNB1 SCIN CASP6 LMNA DFFB PARP3 PARP4 GSN FADD PARP1 PARP2 CFLAR FAS MAP2K4 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway JUNB VAV1 ITPR2 ITPR3 JUND GRAP JAK2 KRAS ITPR1 MYH1 VWF MYH3 PRKX MYO3B MYO3A PRKACB-1 MYH8 PLCB4 MYH9 MYH6 MYH7 GNAQ GNA11 JUN ARAF MYH13 PIK3CD MYH14 PIK3CB GNAI3 MYH11 MYH10 PIK3CG GNAI2 GNG10 MYH7B GNG5 GNG4 AKT1 GNG8 RAC1 PRKCB GNAO1 PRKCE GNB3 GNA14 PLCZ1 PIK3CA PREX1 PLCE1 CCRL2 PLCL1 PF4;PF4V1-1 PLCB3 LTB4R2 PLCB1 CCL3L1;CCL3L3;CCL3;CCL18 PLCD4 RAF1 IFNAR1 PLCB2 CCL13;CCL2 PLCD1 C5AR1 NFATC3 FPR1 NFATC2 CCR10 CCR1 XCR1 NFATC4 NFATC1 CXCL10 PRKCZ CX3CL1 ADCY6 CCR9 ADCY5 NRAS CCR8 PLCG2 CCR7 CCR6 MAPK1 CCR5 PLCG1 CCR4 CCR3 MAPK3 CCR2 RHOG CX3CR1 NFAT5 CAMK2D CCL11 MYLK2 CAMK2A BUB1B-PAK6;PAK6 CXCL8 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 MYLK3 CCL8 COL12A1 MYLK CCL5 CXCR3 ARPC5L CCL22 CCL21 IKBKB CCL20 CCL27 CCL26 AKT2 ROCK1 ACTC1;ACTG2 PAK1 AKT3 PAK3 PAK2 PAK5 ACTG1 PAK4 ARPC4 CHUK PDPK1 RRAS IFNG SOS1 ARPC5 ACTA2 ARPC2 ACTA1 CXCR1 CXCR2 ARPC3 ACTBL2 CASK COL20A1 ITGB1 CXCR4 STAT3 IL2 COL14A1 ARPC1B ARPC1A SHC1-1 ITGAL ITGB7 RHOC RHOA ADCY2 GNAI1 PRKACA-1 COL6A2 RELA GNG2 COL6A1 RELB ACTB-1 COL6A3 NFKB2 CDC42 PTK2B XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP-1 PRTFDC1 GDA HPRT1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease GRIK5 GRIK3 GRIK4 ARPC5L GRIK1 GRIK2 TUBB1 TUBB2B;TUBB2A TUBB3;TUBB6 CYFIP2 GRIN2A CYFIP1 ACTC1;ACTG2 HIP1 AP2A1 AP2A2 CAPN9 ACTG1 CAPNS1 GRIN2C CAPN6 GRIN2B CAPN7 GRIN2D CAPNS2 TUBB4B GRIN1 CAPN5 CAPN2 GRIN3A CAPN3 TUBB4A;TUBB;TUBB8B;TUBB8 CAPN1 IFT57 ACTR2 DYNC2H1 DNAI2 FOS DYNC1LI1 DYNC1LI2 RHOJ GAPDHS HAP1 RHOQ DNAH3 ARPC5 DYNC1I2 ACTA2 DNAH7 DCTN1 SP1 ACTA1 DNAH8 DNAH5 TP63 ACTBL2 HTT KALRN CYC1 DYNC1I1 DYNC1H1 BDNF HIP1R CAPN11 CAPN12 TP53 CREBBP CAPN10 DLG4 TP73 DNAL4 MAP2K4 ARPC1B ARPC1A CASP8 CASP3 MAP3K10 JUN GAPDH-1 APAF1 MAPK9 EP300 TBP RAC1 ACTB-1 MAP2K7 TAF4 CLTB CDC42 RHOG ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation PPP3CA PPP3CB GRAP2 VAV3 VAV1 VAV2 IKBKB AKT2 PAK1 AKT3 PAK3 CALM3;CALM1 PAK2 NFKBIA PTPRC NCK2 CHUK NCK1 FOS SOS1 SOS2 CD86 CD80 CD3G ITPR1 CD3E CD3D PPP3CC ZAP70 LCK LCP2 CD28 CD247 LAT JUN ARAF MAPK9 MAPK8 PIK3CD PIK3CB PIK3CG AKT1 RAC1 HRAS PIK3CA MAP3K1 PIK3C3 PRKCQ RAF1 PIK3R3 PIK3R2 PIK3R1 CDC42 NRAS MAP2K2;MAP2K1 MAPK1 PLCG1 MAPK3 BRAF TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway MAPK14 TRAF6 ECSIT TANK MAP2K3 TBK1 JUN TAB1 IRAK1 IKBKB MAP3K8 MAPK9 IKBKE MAPK8 TICAM2 IRAK4 TICAM1 TIRAP IRF3 TOLLIP TLR9 TLR8 NFKBIA TLR7 TLR10 TLR6 NFKBIE TLR4 MYD88 TLR3 CHUK TLR2 ELK1 MAP2K2;MAP2K1 MAP3K7 MAPK3 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PSAT1 PNPO PDXK WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway TLE6 PYGO1 PYGO2 TBL1XR1 CSNK1G2 EP400 BCL9 PPP2R5E DACT1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A SAG SMARCD1 SMAD1 SMARCD2 HDAC2 SMAD4 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 PLCB4 GNAQ GNA11 GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNA14 PLCB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 CDH3 GNG13 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 WNT8A LRP5 WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 ARRB1 ARRB2 PPP3CA PPP3CB HDAC1 AXIN1 ITPR2 ITPR3 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CREBBP CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 EP300 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 PRKCG DCHS1 PRKCI FAT3 PRKCH PCDHB3 PRKCB PCDHB7 PCDHGB7 PCDHGB6 PRKCE PCDHGB2 PRKCD PCDHA8;PCDHA6-1 PCDHGA8 PRKCA PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PRKCQ PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 NFATC1 CDH16 CDH17 PRKCZ CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 GSK3B PPP3CC GNG2 SMARCAL1 SMARCB1 ARR3 SMARCC1 SMARCC2 CSNK2A2 CSNK2B SRCAP NLK PPP3R1 HLTF SIAH2 GNB1 SMARCA5 FBXW11 INO80 SMARCA1 SMARCA2 BTRC SMARCA4 ANKRD6 TPTEP2-CSNK1E;CSNK1E CSNK1D HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 CTNNA1 TBL1Y CTNNA3 CTNNA2 CSNK1A1 TLE4 CSNK1G3 TLE3 TLE2 TLE1 CHD1L ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP-1 PRTFDC1 XDH ADA APRT HPRT1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACB-1 ADCY10 SNAP25 PRKAR1B PRKAR1A SNAP23 GRM3 GNAI3 GRM2 GNAI2 GNG10 GNG5 SNAP29 PRKAR2B GNG4 PRKAR2A GNG8 GNAI1 VAMP8 PRKACA-1 VAMP1 GNAO1 GNB2 VAMP2 GNB4 GNB3 VAMP3 GNB5 GNB1 CACNA1B CACNA1A GNAT2 CACNB1 STX1A CACNA1E PRKX UNTITLED%PANTHER PATHWAY%P05916 untitled GNB2 GNB4 GNB3 OPRK1 GNB5 GNB1 AVP GNAI3 OXT-1 ADCY7 GNAI2 GNG10 GNG5 GNG4 ADCY2 GNG8 GNAI1 PDYN GNG2 GNAO1 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins CDK5 FES PLXNA1 PLXNB1 FRK ARHGEF1 PAK1 RHOA FYN RAC1 NRP1 DPYSL5 SEMA4D DPYSL2 DPYS SEMA3A CRMP1 DPYSL4 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GRM1 GNB2 GNB4 GRM5 GNB3 CNR1 PLCB3 GNB1 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG5 GNG4 GNG8 GNAI1 CACNA1G GNAO1 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBPL2 TAF8 TBPL1 RRN3 TTF1 CAVIN1 TAF1B PSMC3IP POLR1B TAF1A UBTF TAF1C POLR1D TBP PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PNPO PDXK SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides ADAT2 CDA TK1 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNB2 ADRB2 PRKACB-1 GNB4 GNB3 GNB5 GNB1 GNAL ADCY7 GNG10 GNG5 PRKAR2B GNG4 PRKAR2A ADCY2 GNG8 PRKACA-1 GNG2 PRKX ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release PRKACB-1 GNAI3 ADCY7 GNAI2 GNG10 GNG5 PRKAR2B GNG4 PRKAR2A ADCY2 GNG8 GNAI1 CREM PRKACA-1 GNG2 GNAO1 GNB2 GNB4 GNB3 GNB5 OPRD1 GNB1 GNAL OPRM1 CREB1 PDYN PRKX PENK ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCE PRKCD PLCB4 PRKCA GNA11 PLCE1 PLCB3 PLCB1 PLCB2 ADRA1B ADRA2A ADRA1A ADRA2C ADRA2B PRKCG ITPR1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD FH DLST PDHB DHTKD1 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 GALT UGP2 CANT1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway TRAF3 TRAF6 IKBKG CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 ACO1 L2HGDH SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 CBR1-1 NQO1 ABCC1 ABCC2 ABCB1 NOS3 RALBP1-1 AKR1A1 POR SLC22A16 NDUFS7 NDUFS3 NDUFS2 XDH CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT ASNS GLUL ASRGL1 GLS2 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages PRKCB ITPR1 PLCB1 PRKCA CACNA1D CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS MAPK3 CACNA1C NFKB1 NFKBIA CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD AMBRA1 PIK3R1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis ODC1 SMS AMD1 MAT2B SRM MAT2A ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation LDHD HAGH GLO1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT PDIA2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 GALT UGP2 CANT1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACADL ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT ADH1C;ADH1B;ADH1A BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis TYR DCT PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone GNGT1 GNB1 PRKACB-1 CREB1 FSHR ADCY2 CGA GNAS-1 PPP1CA AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism GLYAT ACSM1 ACSM2A;ACSM2B PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PTPMT1 GPD1 AGPAT5-1 CRLS1 CDS2 PGS1 GPAM GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway ABCC2 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB CHRM1 GNAQ GNGT1 GNB1 PLCB1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPL30 RPLP1-2 RPL3 RPL32 FARSA RPL31 RPL34 RPLP0 FARSB RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 ALDOA GALM-2 PGK1 G6PC1 PFKM PKLR SLC2A2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 CYP2E1 ABCB1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ABCG2 GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation PCCA PCCB DBT SDS DLD BCKDHA BCKDHB MMUT METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 GAPDH-1 ATP5F1A SLC37A4 SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB SLC25A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism NQO1 VKORC1 GGCX LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN1B SCN10A CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism HLCS ACACB BTD SPCS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism HK1 G6PC1 GALE AKR1B1 GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway CYP2E1 ALDH3A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism ACADS HMGCL HADH ECHS1 ACAT1 ACSM1 OXCT1-1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway MVK MVD FDFT1 HMGCS1-1 HMGCR LSS SQLE ACAT1 FDPS IDI1 PMVK BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 GPAM PTPMT1 GPD1 JMJD7-PLA2G4B;PLA2G4B CRLS1 CDS1 DGKA CHAT GDE1 LYPLA1-1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway CFD C5 C6 C7 C9 C3-1 CFP C8A CFB NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides SOD2 SOD3 SOD1 TYRP1 CAT NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 PDIA2 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway RPS6KA1 PTPN6 GRB2 PLCG1 JAK2 SOS1 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR SLC2A4 GHR SOCS1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SLC14A2 SLC4A1 SCNN1G ATP1B3-1 AQP2 AQP3 ATP6V1B1 SCNN1D REN SCNN1B CA1 SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1A1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD1 GAPDH-1 GPD2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP10 CASP6 CASP3 ARHGDIB LMNA FADD MAP3K7 PAK2 SPTAN1 MAP2K4 DFFB JUN DFFA DAXX PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway TUBB1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 ABCC2 ABCB1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 GPT AARS2 AGXT HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 GPX1 DNAJB11 PTGIS ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 CBR1-1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PTGDS GGT1 PTGES PTGS2-2 SLC22A8 SLC22A6 PDIA2 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 AQP1 SLC7A9 CA1 SLC4A4 SLC9A1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway PTPN6 GRB2 PLCG1 JAK2 SOS1 SHC1-1 JUN MAP2K2;MAP2K1 RAF1 HRAS STAT5A EPO MAPK3 FOS ELK1 EPOR MAPK8 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development HOPX SRF GATA4 NKX2-5 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CHRM3 CACNA2D2 PRKCA CACNB1 GLP1R SLC2A2 RAB3A CACNA1A ITPR3 CAMKK1 RIMS2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin HTR6 GNGT1 GNB1 PRKACB-1 CREB1 GNAS-1 PPP1CA METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway OPRM1 GRIN1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN2A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism AHCY MARS1 SLC39A8 METTL6 MAT2B SCLY GGT1 SEPHS2 PAPSS1 CBS;CBSL MAT2A CTH GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 PTGDR GNGT1 GNB1 PRKACB-1 ADCY2 GNAS-1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR4 PLCB1 ADCY1 GNAS-1 SRF NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency SLC25A20 CROT PEX11G CRAT PEX13 PEX14 ABCD2 ACSL1 ABCD1 CPT2 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 HSD17B3 ARGININEMIA%PATHWHIZ%PW000183 Argininemia GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ASL ADSL ASNS ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 FAH GSTZ1 DCT ACSS2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 GPT AARS2 AGXT MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE UXS1 GALK1 GALT GCK UGP2 PGM1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway PRKCA PLCG1 AKT1 PLCB1 PIK3CG PIK3R6 VAV1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT2 PPARGC1A SIRT1 NQO1 NADK NPR1 CLOCK NMNAT1 NAMPT NMNAT3 RORA CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin HTR7 GNGT1 GNB1 PRKACB-1 CREB1 GNAS-1 PPP1CA PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 PTGS2-2 SLC22A6 PDIA2 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 SLC6A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A PRKACB-1 KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway PCSK2 CYP1A2 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CHRNB2 CHRNA3 AOX1 CYP2A13;CYP2A6;CYP2A7-1 CHRNA4 FMO3 CYP2B6 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis SHMT1 TMLHE SETD7 BBOX1 ALDH9A1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA ABCC4 ABCC5 SLC29A1 SLC28A3 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME2 AK1 AK2 NME1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA ABCC4 ABCC5 SLC29A1 SLC28A3 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 GCLC CTH MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 PRKCA RASA1 CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOS ELK1 SRF FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO PDXP ALPL AOX1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 MARS1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway TYMP TYMS CES1 CDA SLC28A1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism TYR FLAD1 RFK ENPP1 ACP1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 PCSK2 CHRNA4 HYOU1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PDIA2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACADL ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis PLPP1 AGPAT1 GNPAT AGPS CEPT1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME2 AK1 AK2 NME1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 SLC2A2 GCK PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOA MAOB CYP2D6;LOC107987479;LOC107987478-1 AOX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 SLC2A2 SLC2A4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 PGAM2 TALDO1 PGD ENO1 PDHA1 HK2 IDH3G RPIA GAPDH-1 IDH1 PFKL PGLS SDHC SDHD SDHA TKT SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD SLC2A2 PKLR MDH1 LDHA SLC16A1 PKM ALDOB PGK1 FH DLST PDHB DHTKD1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR NSDHL EBP ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway MTOR MAPK1 TYK2 JAK1 STAT3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CDC42 CASP9 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 CHUK AKT1 RAF1 RALGDS RALBP1-1 HRAS MAPK3 ELK1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis HSD3B1;HSD3B2 CYP11B1;CYP11B2 CYP11A1 AGTR1 GNG2 CYP21A2 GNAQ GNB1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 GCLC CTH ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR5 GNAS-1 SRF MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 HRAS PIK3CG PIK3R6 INS;INS-IGF2 IRS1 INSR PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked SLC25A20 CROT PEX11G CRAT PEX13 PEX14 ABCD2 ACSL1 ABCD1 CPT2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System DRD1 PRKACB-1 ADCY2 GNAS-1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway EPHX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway CDKN1A PCNA GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 BCL2 CDK1 E2F1 BAX APAF1 RB1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMA1 PSMC3 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2E1 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary TPI1 HK1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway PPP3CB PPP3CC BLNK RAC1 GRB2 PLCG1 LYN SYK PRKCB NFATC3 SOS1 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 FOS ELK1 CD79B PPP3CA CD79A LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR1 SRF PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ASL ADSL ASNS ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT2 PISD PEMT CEPT1 PCYT1A CHKA HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 TOP2A DFFA CAD GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA ADCY10 PRKAR1B PRKAR2B PRKAR1A GNGT1 PRKAR2A GNB1 PRKACB-1 GNAS-1 PRKACA-1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC C6 C7 C9 C3-1 C8A C1QB C1S C1R GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NMNAT2 NADK AOX1 PNP-1 NNMT QPRT NADSYN1 ENPP1 BST1 NNT NT5C2 NMRK1 NUDT12 NAMPT SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 PTGS2-2 TOP2B ABCC3 PDIA2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 SLC22A1 CRK ABCB1 BCL2L1 STAT5A SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 AADAT KYNU AFMID CYP1A1 IDO1 DDC CAT HAAO TPH1 ASMT LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA CHUK MDH1 NFKB1 ACACA IKBKB NFKBIA HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis AVPR2 GNGT1 GNB1 PRKACB-1 FSHR ADCY2 GNAS-1 COAGULATION%SMPDB%SMP0000586 Coagulation F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ALDH2 CYP2E1 ACSS1 ALDH1B1 ACSS2 ADH1C;ADH1B;ADH1A CAT MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia HK1 G6PC1 GALE AKR1B1 GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR NSDHL EBP TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway TUBB1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 ABCC2 ABCB1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 SIRT1 NQO1 AIFM2 TP53 NADK CD38 NMNAT1 NAMPT NMNAT3 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 FH DLST PDHB DHTKD1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1A4 SLC12A6 ATP1B1 ATP1A3 SLC12A1 ATP1A2 ATP1B3-1 ATP1A1 REN FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK GNGT1 PXN RAF1 CXCR4 HRAS PIK3C2G MAPK3 GNAI1 PTK2 NFKB1 CXCL12 PTK2B NFKBIA BCAR1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway AGTR1 ACE REN AGT DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway PCSK2 AOX1 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 GPT AARS2 AGXT TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAP2K3 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 CHUK MAPK14 NFKB1 IKBKB NFKBIA MAPK8 ATF1 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL SLC25A20 HADH CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 HADHA CPT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway PCSK2 AOX1 CHRNA4 CYP2A13;CYP2A6;CYP2A7-1 SLC6A2 ADRA1A SLC6A3 SLC6A4 CYP2B6 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A FMO3 ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CHRNA3 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CNDP1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle GOT2-1 MDH2 SLC25A12 SLC25A11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway ALDH7A1 DMGDH SHMT2 SHMT1 SLC44A1 GNMT SLC44A2 MAT2B MTR-1 BHMT SARDH MAT2A CHDH PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C2 MBL2-1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C5 C6 C7 C9 C3-1 C8A FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway TYMP TYMS CES1 CDA SLC28A1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria PC MPC1 ME1 PDHA1 SLC25A11 MDH1 ACLY PDHB CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2RY12 ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway ADRA1A CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K3 RAC1 GRB2 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MAP2K4 MS4A2 VAV3 LAT PIK3R1 PIK3CA AKT1 INPP5D MAPK14 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 L2HGDH SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form HLCS ACACB BTD SPCS1 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ASL ADSL ASNS ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 CDO1 GAD1 CSAD ADO SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA ABCC4 ABCC5 SLC29A1 SLC28A3 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation HOXB9 BTG1 CHAF1A PRMT1 TP53 FGF1 CCND1 NGF RB1 BTG2 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 GUCY1A1 NOS3 TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 KCNQ4 KCNQ5 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway SLC22A3 ABCG2 CHPT1 PCYT2 CMPK1 PGK1 ABCC1 ABCC2 SLC22A1 ABCB1 ABCC4 DCK NME1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A2 PCYT1A ABCC3 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 SLC6A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE UXS1 GALK1 GALT GCK UGP2 PGM1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP2C9;CYP2C19 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 PTGS2-2 TOP2B ABCC3 PDIA2 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A1 PNP-1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 SLC2A4 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine SARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR2 PLCB1 ADCY1 SRF BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 NR1H4 SLC10A2 FGFR4 FGFR3 FGFR2 FGFR1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SNTA1 CACNB1 ABCC8 SNTB1 SNTB2 SLC2A2 CACNA1A CACNA2D2 GCG SCN5A FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria TPI1 HK1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids SLC25A20 CROT PEX11G CRAT PEX13 PEX14 ABCD2 ACSL1 ABCD1 CPT2 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin PTGIR MYL3 MYLK GNGT1 GNB1 PRKACB-1 ADCY2 GNAS-1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 TRAF6 IKBKG ECSIT RELA IRAK1 TLR1 TOLLIP TLR9 TAB3 TLR8 TLR7 TAB2 TLR6 TAB1 MAPK8 TLR5 TLR3 TLR2 MAP3K7 MAP2K4 LY96 TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK MAPK14 NFKB1 IKBKB NFKBIA GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 PDIA2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PPCS PANK1 COASY PPCDC ENPP1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine RPS6KA1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 JUN ADORA2A RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA GNGT1 MAP3K1 PRKACB-1 AKT1 CHUK CREB1 ELK1 GNAS-1 NFKB1 IKBKB PDPK1 NFKBIA ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor PRKCA GNAQ ITPR1 PLCB1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE UXS1 GALK1 GALT GCK UGP2 PGM1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway ADRA1A CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CNDP1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids ACADM SLC25A20 HADH ECHS1 HADHB-1 ACAA2 HADHA ACSM1 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism UGT1A1;UGT1A6 PDIA6 CYP11B1;CYP11B2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 HSD11B1 PDIA2 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD FH DLST PDHB DHTKD1 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 VEGFA KDR NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 OPRM1 PPIB SDF2L1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSPA5 HYOU1 PDIA2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PCYT2 PISD PTDSS1 CEPT1 CHKA METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 YARS1 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism MINPP1 IMPA1 PIK3C3 ITPKA INPP5J PLCD3 VAC14 BECN1 PTPMT1 PIK3R4 AMBRA1 PIK3CA FIG4 IPPK PIKFYVE MIOX ISYNA1 INPP1 ITPK1 IPMK PI4KA INPP4A PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway EHHADH-1 HSD17B10 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ACADSB HADHA CYP2B6 ACSM1 IVD PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 LCT SLC2A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTA1 SNTB1 SNTB2 SCN5A LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway ABCC10 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway PRKCA ADAM17 EGFR ERBB3 ERBB4 NRG2 PSEN1 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway CDKN1A PCNA RAC1 CCND1 CAP1 VAV3 PDGFRA WASF1-1 LIMK1 CCND3 CDK5 PLD1 ACTB-1 MYLK RPS6KB1 MYL2 CFL1 ARFIP2 PPP1R12B MAP3K1 RALBP1-1 PAK1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 ALDOA GALM-2 PGK1 G6PC1 PFKM PKLR SLC2A2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRAF6 IKBKG TRADD TNF RIPK1 RELA IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B TNFRSF1A IL1A MAP3K14 TAB1 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 CHUK NFKB1 IKBKB NFKBIA METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway PCSK2 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 CYP2B6 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS1 JMJD7-PLA2G4B;PLA2G4B FADS2 ELOVL4 ELOVL5 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 HSD17B3 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism PEMT AHCY MAT2B MTR-1 BHMT ALDH7A1 MAT2A CHDH BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency HLCS ACACB BTD SPCS1 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A CARS1 RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 GPT AARS2 AGXT CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway IMPDH2 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CES2 CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT ADH1C;ADH1B;ADH1A BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2RY12 ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine RPS6KA1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 MAPK8 PAK1 ADORA2B ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA GNGT1 MAP3K1 PRKACB-1 AKT1 CHUK CREB1 ELK1 GNAS-1 NFKB1 IKBKB PDPK1 NFKBIA FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 ALDOA GALM-2 PGK1 G6PC1 PFKM PKLR SLC2A2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell SST CACNB1 ABCC8 SLC2A2 CACNA1A CACNA2D2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling TSC2 TSC1 RHEB EIF4EBP1 EIF4E SLC7A5 MTOR RPS6KB1 AKT1 PIK3CG PIK3R6 INS;INS-IGF2 IRS1 INSR IRS2 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling TLR4 P4HA3 IL1B NLRP3 HIF1A SIRT3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 OPRK1 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 GNB1 PRKACB-1 CREB1 GNAS-1 PPP1CA HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT PDIA2 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway MAP2K3 GRB2 PRKCB SOS1 ITPR1 PLCB1 MAP2K7 PRKCA CACNA1D CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CALML6 CACNA2D2 SRC LHB CAMK2A PLD1 GNA11 CDC42 GNRHR CACNB1 MAP3K2 EGR1 EGFR MAP3K1 MMP2 FSHB ACTN4 ADCY1 MMP14 CGA LRRC7 ELK1 MAPK14 GNAS-1 GNRH1 HBEGF ATF4 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MAP2K3 TRAF6 IKBKG MAP2K6 ECSIT RELA IRAK1 TOLLIP TLR9 TLR7 TAB2 TAB1 MAPK8 TLR3 TLR2 MAP3K7 MAP2K4 LY96 JUN TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK FOS ELK1 MAPK14 NFKB1 IKBKB EIF2AK2 NFKBIA PPARA CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PTPMT1 GPD1 AGPAT5-1 CRLS1 CDS2 PGS1 GPAM T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway CD3G PPP3CB CD3E PPP3CC CD3D RAC1 GRB2 RASGRP1 PLCG1 PRKCB ZAP70 NFATC3 LCK SOS1 NFATC2 PTPN7 SHC1-1 NFATC1 CD247 CALM3;CALM1 NFATC4 PRKCA RELA MAP2K2;MAP2K1 RAF1 HRAS PIK3CG MAPK3 VAV1 MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 FOS ELK1 NFKB1 PPP3CA NFKBIA MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 AOX1 IMPDH1 GMPS ABCC4 ABCC5 SLC29A1 SLC28A3 XDH FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA1C CACNA2D2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCA PLCG1 PRKCB P2RY2 PTK2B MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway PRKCA ALDH2 NOS1 GRIN1 PRKACB-1 ITPR1 CALM3;CALM1 GRIN3A DLG4 PPP3CA GRIN2A XDH METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO PDXP ALPL AOX1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD AMBRA1 PIK3R1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway PCSK2 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 GCLC CTH BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLCO1A2 NR1H4 SLC10A2 GPBAR1 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids ALDH2 SLC25A20 CRAT PEX13 PEX14 ABCD2 ACSL1 HACL1 PHYH-4 ABCD1 CPT2 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 GALT UGP2 CANT1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PDIA2 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production GNGT1 GNB1 PRKACB-1 POMC MC2R GNAS-1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 GNB1 AKT1 ADCY1 GNAS-1 SRF LPAR6 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation TPI1 HK1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC6A2 SLC6A4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin LHB GNGT1 GNB1 PRKACB-1 CREB1 ADCY2 CGA GNAS-1 PPP1CA LHCGR LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 LCT SLC2A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 LPIN1 GPD1 AGPAT1 GPAM SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation ALDH8A1 ACMSD DLD DLST DHTKD1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism MINPP1 IMPA1 ITPKA INPP5J NUDT3 PPIP5K1 IP6K1 INPP4B IPPK ISYNA1 INPP1 ITPK1 IPMK INPP4A ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 HSD17B3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule CLCNKA;CLCNKB SLC12A3 ATP1B3-1 AQP2 AQP3 ATP4B REN ATP4A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1A4 ATP1B1 ATP1A3 TRPV5 ATP1A2 ATP1A1 SLC8A1 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation IKBKG PLCB1 MAPK11 PTGS1 PRKCA MAPK1 SUCNR1 CHUK NOS3 CREB1 MAPK3 NFKB1 IKBKB TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway CASP8 CASP10 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 PRF1 ARHGAP5 ARHGAP32 CASP1 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine HRH2 GNGT1 GNB1 PRKACB-1 CREB1 ADCY2 GNAS-1 PPP1CA DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR3 GNAS-1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors PIAS1 NR3C2 NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA PIAS4 HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MINPP1 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA PPIA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes CPS1 ARG1 TP53 OTC GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 GPCPD1 PLAAT4 HADHA PITPNM1 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 MGLL PLA2G1B AGPAT1 AGPAT2 ALPG;ALPP;ALPI-1 SELENOI AGPAT3 AGPAT4 GPAT4 AWAT2 GPAT3 GPAT2 CEPT1 CDIPT PLA2G10;LOC100652777 PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 LPIN1 LPIN2 LPIN3 PNPLA2 LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 PLA2G2A-1 LIPI LIPH JMJD7-PLA2G4B;PLA2G4B CPNE3 MFSD2A DGAT2 MIGA2 PCYT2 MIGA1 DGAT1 STARD7 CSNK2A2 GPD1L-1 PISD PLA2G15 ABHD3-2 GNPAT PHOSPHO1 GPD2 GPD1 CSNK2B PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 CHAT PLD4 PLA2G3 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT CDS2 SLC44A5 ACHE SLC44A3 HADHB-1 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A PLA2G4D PLA2G4E PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling EGF ERBB2 PLCG1 EGFR REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PPP1CB MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC CEP290 YWHAG RAB8A SKP1 CDK5RAP2 HSP90AA1 OPTN-1 CEP135 PPP1R12A BORA FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 UBB;UBC CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BCL2L11 BAD STAT3 BCL2 PMAIP1 BMF BID BBC3 BCL2L1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix COL16A1 CTRB1;CTRB2 COL12A1 CAPN8 CAPN9 CAPNS1 CAPN6 CDH1 CAPNS2 CAPN7 BSG CAPN5 CAPN2 CAPN3 CAPN1 CAST PHYKPL COL23A1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 PSEN1 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LAMC1 CTSS MMP20 ADAMTS4 ADAMTS5 MMP25 MMP24 ADAMTS1 CTSK CASP3 TIMP2 KLK3;KLK2 CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 CTSB CTSV;CTSL MMP7 COL25A1 MMP1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 CD44 TPSAB1;TPSB2;TPSD1 LAMA5 COL15A1 TMPRSS6 LAMA3 FURIN PLG COL19A1 ACAN SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 PRSS3;PRSS2;PRSS1 CAPN12 CAPN10 TLL2 TLL1 KLKB1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression MGLL AGPAT2 GPAM LPIN1 PNPLA2 AJUBA RB1 SMARCB1 CCNH EHMT2 EHMT1 RRP8 LIPE H2AC14 TRIM28 SAP130 DPF1 PDK4 DPF2 DPF3 KAT8 MED1 SAP30BP SMARCC1 SMARCC2 ACSL1 HCFC2 MED4 MED6 MED7 HCFC1 WDR82 PAXIP1 PEX11A BAZ2A ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PPARGC1B CREBBP ZNF382 SETDB1 SS18L1 SETD1B SETD1A SMARCA5 SMARCA2 CIDEC SMARCA4 TADA2A ZZZ3 H2AC20 ZNF30 H2AB2;H2AB3;H2AB1 EZH1 EZH2 CBX3-1 PHF20 SUV39H1 PHF1 ASH2L SGF29 MED16 MED17 MED12 MED14 MED13 MED10 CD36 JARID2 NCOA1 NCOA2 SS18 NCOA6 ELOVL5 NCOA3 ACTL6A TET2 TET1 PPHLN1 MED27 BAZ1B SIRT1 MED23 PHF20L1 NCOR2 KAT2B H2AJ KAT2A NR5A2 NCOR1 MED24 AEBP2 TET3 MTF2 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 SF3B1 MBD3 SUZ12 H2BC5 MCRS1 MBD2 H2BC1 ZNF669;ZNF670 GTF2H1 GTF2H3 GTF2H4 GATAD2B GATAD2A FABP4 MYBBP1A MED31-1 MPHOSPH8 ZNF331 ARID4B TTF1 EP300 MTREX PHLDA1 MEN1 BOD1L2;BOD1 H2AC4 ADIPOQ SAP30 SPOCD1 TBL1XR1 ZNF317 ZNF354A;ZNF354B-4 ZCCHC8 KMT2D DNMT1 KMT2A KMT2C KMT2B BOD1L1 LPL MED30 TASOR ABL1 MBIP TASP1 SUDS3 ZNF324B;ZNF324 MORC2 DR1 CBX5 CDK8 CDK7 CDK5 YEATS2 ACTB-1 TADA3 MNAT1 PHF19 GSK3B PIWIL4 AKAP8L PSIP1 DPY30 UBE2I CHD4 CHD3 PAGR1 DNMT3L BCL7A SIN3B SIN3A H2BC21 BCL7C ZNF649 BCL7B UBTF DNMT3B RXRA WDR5 RBM7 KDM6A SUMO2 TBP EED DNMT3A H2AZ2;H2AZ1 ARID1A ARID1B ZNF264;ZNF805-1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 SMARCD1 CEBPA GTF2H2C;GTF2H2C_2;GTF2H2 SMARCD2 ACSS3 HDAC2 SMARCD3 HDAC3 DGAT2 UHRF1 HDAC1 CXXC1 DDX21 TAF1D MTA1 TAF1B RBBP4 TAF1C RBBP5 SAP30L TDG TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L SMARCE1 ATF7IP DEK EPOP H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 ERCC3 KANSL2 SCD KANSL3 ERCC2 THRSP ERCC6 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides S100A8 LTF TLR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB123 DEFB121 ART1 ITLN2;ITLN1-2 PDZD11 RNASE7 CHGA DEFB135 DEFB107A;DEFB107B S100A7A;S100A7 DEFB132 ATOX1 DEFB130B;DEFB130A DEFB105A;DEFB105B CD4 BPIFB2 BPIFB1 BPIFB4 BPIFB6 LCN2 DEFB103A;DEFB103B DEFB4A;DEFB4B ELANE PLA2G2A-1 CTSG EPPIN;EPPIN-WFDC6 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 LYZ-1 DEFB1 CLU DEFB109B BPIFA1 REG3G;REG3A-1 CCR6 ATP7A PGLYRP1 CAMP CCR2 PRSS3;PRSS2;PRSS1 DEFB131B;DEFB131A DEFB119 DEFA6;DEFA4;DEFA5 DEFB118 DEFB116 SLC11A1 DEFB114 RNASE6 DEFB110 TLR1 RNASE3;RNASE2-2 BPI S100A9 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RIPPLY2 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 PSMD8 LFNG PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES7 EPHA4 ADRM1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism HLCS MCCC1 PCCB ACACB ACACA MCCC2 SLC5A6 PDZD11 BTD PC PCCA SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLC10A6 SLC44A5 SLC44A3 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 YWHAB HSPA1A;HSPA1B HSPB1 ELAVL1 ZFP36 XPO1 KHSRP AKT1 UBA52 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ XRN1 MAPKAPK2 PARN ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 SET-1 EXOSC9 RPS27A EXOSC8 DCP2-1 EXOSC3 EXOSC2 UBB;UBC EXOSC1 HSPA8 PABPC1;PABPC3 MAPK14 ANP32A;ANP32D MAPK11 DCP1A EIF4G1 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state IFT57 DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 RBX1 GNAS-1 IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 NUMB INTU ADCY4 ADCY3 TULP3 GSK3B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 PSMD12 WDR19 IFT122 PSMD11 FUZ PSMD14 ADCY10 PSMD13 ITCH MKS1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 PRKACA-1 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CUL1 PRKAR2B RPS27A UBB;UBC OFD1-1 IFT172 GLI1 GLI3 GLI2 IFT52 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 FKTN SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 ERCC6 GATAD2B GATAD2A H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 TTF1 H2AC4 EHMT2 HDAC2 H2AC14 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs RBX1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 SPRED3 PSMB2 SPRED2 PSMB3 RASA4;RASA4B PSMD2 SPRED1 PSMD3 SYNGAP1 PSMB1 PSMD1 HRAS RASA3 RASA1 RASA2 ADRM1 CUL3 RASAL1 PSMC2-1 RASAL2 RASAL3 PSMA2-1 PSMA5 NRAS DAB2IP SEM1 PSMA6 NF1 PSMC5 KBTBD7 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 RPS27A UBB;UBC ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3-1 CFB HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 CD4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 XPO1 UBA52 NUP214 GTF2H1 GTF2H3 GTF2H4 RPS27A UBB;UBC CDK7 MNAT1 PSIP1 TBP PPIA GTF2H2C;GTF2H2C_2;GTF2H2 CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 BANF1 KPNA1 SUPT16H NUP210 POLR2E LIG1 LIG4 POLR2F GTF2F1 POLR2H GTF2F2 NUP93 CHMP4C CHMP4B POLR2L CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 ERCC3 GTF2E2 NUP160 NUP85 TPR ERCC2 NUP88 SUPT4H1-1 XRCC6 NUP155 XRCC4 FURIN XRCC5 VTA1 NUP153 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 ELOA NELFB ELOB CCNH NELFCD NELFA CCR5 NELFE NDC1 SEC13 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation GLB1L2 BCAN VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB DCN IDUA HEXB NCAN HEXA BGN GLB1L3 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes CHUK UBA7 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 IFI44L HERC5 IFIH1 IKBKB TRIM25 ARIH1 IKBKG ATF6 FKBP5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling NGF AP2A2 DNM1 DNM2 DNM3 AP2S1 DNAL4 SH3GL2 NTRK1 CLTC CLTA AP2A1 AP2B1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAT2 PPP2R1B APC PPP2R5E GSK3B CSNK1A1 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib CDC37 ERBB2 ERBIN HSP90AA1 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 MICU3 PMPCA MICU2 MICU1 MCU STOML2 MCUB SPG7 PHB MAIP1 PHB2 PARL AFG3L2 SMDT1 YME1L1 PMPCB KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development ITGB1 ROBO2 RET FOXC2 FOXC1 SIX1 CTNNB1 GATA3 PCDH19 HOXD11 FGF2 HOXC11 WFDC2 HOXA11 PLAC8 SALL1 WNT11 MECOM SIX2 HNF4A SLIT2 HOXA6 WNT4 IRX1 IRX2 EMX2 JAG1 EYA1 OSR1 WNT9B GFRA1 HNF1B NPNT PAX2 DLL1 POU3F3 GREM1 BMP4 PAX8 LFNG GDNF WT1 LHX1 ID4 ITGA8 HOXB4 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK FRS2 HDAC1 MYCN PIK3CA PTPN6 STAT3 SIN3A EP300 ALK CD274 IRS1 PIK3R2 PIK3CB PTN PLCG1 PRDM1 PIK3R1 IL2RG HIF1A PTPRZ1 DNMT1 MDK MYC HDAC2 ALKAL2 ALKAL1 HDAC3 JAK3 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat NCBP1 CCNK CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 CCNT2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 CDH11 AGO3;AGO1 TNRC6B RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF KRAS RUNX3 RUNX1 HDAC4 BRD2 TGFB1 EP300 CCND1 CBFB BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 ALOX5 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants CDC37 ERBB2 ERBIN HSP90AA1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 SUMO1 UBE2I TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX TNRC6C MOV10 TNRC6A-1 AGO4 CTNNB1 AGO3;AGO1 TNRC6B CCND1 CSF1R CEBPB ANAPC15 ANAPC16 LEF1 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 TP53 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EHMT2 EHMT1 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection RPS14 GJA1 RPS17 TLR2 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN ST3GAL1 ST3GAL2 ST3GAL3 VPS16 SRPK2 EDEM2 PARP16 PARP14 SRPK1 PARP10 RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE YWHAE JAK1 TOMM70 PARP6 PARP4 PRMT1 RIPK2 SFTPD ANO8 ANO9 ANO6 TYK2 ANO4 PARP9 IL17RC ANO5 ANO2 PARP8 YWHAG IL17RA ANO3 ANO1 SIKE1 HSP90AA1 SMN2;SMN1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 YWHAB RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 AKT1 UBA52 GPC4 RPS2 NUP214 MGAT2 GPC6 STAT1 STAT2 SEC24D-1 YWHAZ MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 RPS27A CRB3 IL17A TUSC3 GEMIN2 UBB;UBC KPNA2 MAP3K7 RPS9 RPS7 RPS8 RPS5 VPS33A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU IFNAR1 SNRPB DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG CAV1 MAVS OSTC STT3A UBE2N TAB3 CSNK1A1 TAB2 STT3B TAB1 HSPG2 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 IRF3 DAD1 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB SNRPG-2 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 NUP107 MGAT4B NUP188 VPS45 SEC24C CTSV;CTSL NUP210 NUP93 CHMP4C CHMP4B CHMP4A NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 FURIN NUP153 CHMP2B CHMP2A NUP62 RB1 NDC1 SEC13 NUP133 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 NUP42 CREBBP NUP43 RAE1 RANBP2 NUP35 NUP37 CHUK DDX58 ISG15 IFIH1 IKBKB TRIM25 IKBKG GSK3B UBE2I SUMO1 PTPN6 PATJ ZDHHC5 ZDHHC8 TLR1 ZDHHC2 ZDHHC3 RPS15 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome NCBP1 CDK7 GTF2A1 GTF2A2 CTDP1 MNAT1 RNMT TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 RNGTT TAF12 TBP TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 GTF2B SUPT16H POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L GTF2E1 ERCC3 GTF2E2 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B ELL ELOC-1 TAF7L ELOA NELFB ELOB CCNH NELFCD NELFA NELFE REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNA2-1 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding PFDN6 TUBAL3 GBA ARL2 GNA14 AP3M1 GNG10 STAT3 GNA15 GNG2 GNG5 GNG4 CSNK2A1;CSNK2A3 GNA11 GNG8 CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 NOP56 ARFGEF2 TBCD TBCC TBCB TBCA GNG13 CCT6A GNAQ GNB2 TBCE GNB1 PDCL GNB4 GNB3 SKIV2L FBXL3 GNB5 RGS11 FBXL5 TUBA8 WRAP53 TP53 HDAC3 TUBA1A CSNK2A2 CSNK2B TUBA4A DCAF7 CCT6B PFDN4-1 GNGT1 TUBA1C KIF13A TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 CCT3 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS PFDN1 TUBB4B PFDN2 FKBP9 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins TRIM28 HDAC1 MTA1 RBBP4 ZNF324B;ZNF324 CBX5 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 ATF7IP CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ZNF382 SETDB1 H2BC21 H2BC1 ZNF669;ZNF670 ZNF649 GATAD2B GATAD2A H2AC20 SUMO2 ZNF30 H2AB2;H2AB3;H2AB1 ZNF331 H2AZ2;H2AZ1 ZNF264;ZNF805-1 H2AC4 ZNF317 ZNF354A;ZNF354B-4 HDAC2 H2AC14 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG GALE INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP H2BC21 NOTCH1 ST3GAL4 RBPJ ST3GAL3 H2AC20 H2AB2;H2AB3;H2AB1 LFNG B4GALT1 H2AZ2;H2AZ1 POGLUT1 MAML2 MAML1 POFUT1 PRKCI TMED2-1 SIRT6 TP53 TFDP1 ELANE ELF3 TFDP2 MFNG MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 E2F3 ST3GAL6 RAB6A JUN SNW1 MAMLD1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 KAT2B AGO3;AGO1 ATP2A3 H2AJ TNRC6B KAT2A ATP2A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 ATP2A1 RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 FURIN EP300 H2AC4 H2AC14 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 MAPK7 MAP2K5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 STAT3 NR3C1 EGF ERBB2 HRAS EGFR RASA1 HIF1A NRAS CDKN1B LRRK2 ARHGAP35 SFPQ-1 RAC1 PELP1 NRG1 CCND1 NRG2 ARAP1 RHOA EREG BTC DOK1 NRG3 NRG4 ELMO1 ELMO2 CRK DOCK1 HBEGF KHDRBS1 KHDRBS2 KHDRBS3 AKT1 UBA52 EPAS1 PXN CBL SOCS3 GPNMB STAP2 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 RPS27A UBB;UBC CCNE1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) SUMO1 SUMO3 SUMO2 UBA2 SAE1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism PANK4 SLC5A6 PDZD11 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 TYW5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript NCBP1 NUP133 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 NUP50 GLE1 POM121;POM121C NXF2;NXF2B;NXF5-1 THOC1 NUP54 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 NUP42 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A NUP43 POLDIP3 SRSF1 NXF1 U2AF2 RAE1 FYTTD1-1 RANBP2 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NCBP2-1 NUP35 NUP37 NUP107 NUP188 NUP210 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD ABCD1 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels MCOLN1 TRPC4AP MCOLN2 TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation TICAM2 TRADD LY96 FASLG TRAF2 TICAM1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CD14 FADD TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation UBE2V1 UBE2N TAB3 TAB2 PSMD12 TAB1 PSMD11 PSMD14 PSMD13 PSMA7 PDPK1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 TRAF6 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 CDC34 IKBKB PRKCQ CARD11 BCL10 IKBKG RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 UBA52 NFKBIA CUL1 UBE2D1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 TIAM1 BDNF CDK5R1 RAC1 CDK5 NTRK2 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB PTK6 EGFR LRRK2 HIF1A HBEGF DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 GCKR NUP155 GCK NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM2 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1-1 TGFBR2 TGFB1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation FRS2 NGF MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 YWHAB BRAF MAPK3 CRKL FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 HRAS FGF1 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters SLC34A2 SLC34A1 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly APOC1 MTTP APOC4 P4HB APOB REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase CDK1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 ANAPC15 ANAPC16 CUL1 UBE2D1 ANAPC10 CCNB1 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PLK1 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBB;UBC RPS27A UBA52 METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism NR1H4 G0S2 NR1H3 GNMT AGMAT MKLN1 GATM ARSD-1 COQ8A N6AMT1 VKORC1L1 ADH1C;ADH1B;ADH1A TPMT RPL10A TM7SF2 PPP1CC MPC1 MPC2 SLC26A11 CSGALNACT1 RARS1 DIO1 CSGALNACT2 IPMK DIO3 KERA PGD SLC25A51;SLC25A52 RPE;RPEL1 CSNK1G2 IPPK SLC26A2 SLC26A1 INSIG2 INSIG1 HMMR MTM1 TPO MPC1L OSBPL9 COA3 RAB4A OSBPL7 OSBPL6 OSBPL3 OSBPL2 GCSH-3 M6PR PHKB SYNJ2 PUDP SYNJ1 NFYA-1 RAB5A RPL36AL-1 GAL3ST1 ADPGK AMD1 AZIN1-2 PIK3C2G PIK3C2A FTCD PIK3C2B IDH3B PRKG2 HMGCS2 LBR IDH3A COA5 ADSL GGPS1 CHPF2 FAAH2 APOA2 APOA1 APOA4 BPGM GSTT2B;GSTT2 APOA5 TST ALDH9A1 PDHB BPHL TTR BCO2 BCO1 ALOXE3 IDH3G CYP51A1 APOC3 BCKDK RAB14 VAPA VAPB PSAT1 CTH APOC2 SLC35B3 ISCA2 SLC35B2 ISCA1 MTRR GBA2 HS6ST1 HS6ST2 HS6ST3 CBS;CBSL RPL18A FLAD1 PDK3 CIAO2B SEPHS2 PDK2 PDK1 PDHX CPT1A SLC51A SLC51B CPT1B TIAM2 POR CYP2U1 MTHFD2L SUCLG2 SUCLG1 SLC22A4 RTEL1 SLC22A5 SLC35D1 STXBP1 SLC35D2 LHB TXN HELZ2 UGCG PRODH;LOC102724788 PYCR1 PYCR2 PYCR3 TYR DERA PM20D1 HAL LDHA;LDHC CYP2S1 C12orf73 CD320 GBE1 INS;INS-IGF2 SLC22A13 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 BHMT2 CYP7B1 DHFR2;DHFR UGDH ACBD5-1 NUDT11;NUDT10-1 DTYMK HAAO HDC GDPD1 LYPLA1-1 ZDHHC21 GDPD3 TYMS GDPD5 CYP7A1 PTS TYMP NT5C DUOX1 NT5E PDPR MTHFD1L SPTSSB NT5M CBR4 ACOT2;ACOT1 DUOX2 CBR3 ATP5PF ATP5PD PTGES2 NFYB ATP5PB NFYC GRHL1 PDP1 CYP2W1 PDP2 GSTA4 ATP5PO NDUFA13 NDUFA11 NDUFA12 NDUFA10 COMT CNDP2 CSKMT HADH RPL15-1 HGD NOSIP PNLIP IDI1 ISYNA1 IDI2 ALOX15 ALOX12 ATP5MJ ATP5MG ATP5ME MPST UQCC3 UQCC2 UQCC1 IDH1 IDH2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 COQ9 COQ7 GSTA3;GSTA1 COQ6 COQ5 GLUD1;GLUD2 SEPSECS COQ3 GRHPR COQ2 AMACR DAO PXMP2 PI4KA CRYL1 PI4KB LRP10 LRP12 GLP1R DBH OPLAH HK2 HK1 HS2ST1 HK3 CYP2R1 DBT DCK PRODH2 LSS DDAH1 DCT THRAP3 ALDH1A1 RBKS VAC14 PDXK DDC ETFDH DDO UGP2 ALDH1B1 FAM120B PDSS2 CHSY3 PDSS1 NOS3 LUM CHSY1-1 ST20-MTHFS;MTHFS UXS1 IL4I1 AS3MT NSDHL ALDH3B2;ALDH3B1 TDO2 LRAT XYLB STARD3 STARD4 STARD5 STARD6 UPB1 RUFY1 RBP4 SLC5A8 RBP2 ETHE1 RBP1 UQCRC1 UQCRC2 IDO2 HPD IDO1 MTMR1 HACD1 MTMR2 HS3ST3A1 MTMR3 RETSAT ABCB7 RPL10;RPL10L-1 ABCB4 MTMR8 MTMR9 IQGAP1 MTMR4 HACD3 HACD2 OAZ1 MTMR6 HACD4 MTMR7 SLC5A5 HSD11B1 HSD11B2 UGT8 CYP2B6 CYB5R3 HAO1 GPIHBP1 ABCA1 GLYATL3 B3GALNT1 CS BHMT UCK1 NOSTRIN ARF1 QPRT RPLP0 ECSIT AACS TRMT112 B3GALT2 B3GALT1 RPLP2 RPL36-1 ELOVL1 ARG2 ELOVL4 ELOVL2 PGAM1 PGAM2 ELOVL3 SIRT4 SIRT5 ELOVL6 ELOVL7 PTGR2 SUMF2 SUMF1 SIRT3 BDH2 BDH1 DLD VAMP2 GOT2-1 FH DMAC2 KARS1 UCP1 PET117 PTGS1 CYCS-1 EXTL2 UCP3 HAS1 UCP2 CARNS1 HAS3 HAS2 CYP2F1 GC EXTL3 MDH1 GK AADAT MDH2 FABP9 GSTM1;GSTM2-1 FABP1 LETM1 FABP2 LYRM2 FABP3 HSD3B1;HSD3B2 AADAC FABP5 LYRM4 FABP6 FABP7 LYRM7 RPL22L1 PECR HNMT SAT1 HMGCS1-1 STK11 HPGDS OSBP RPL37A-1 SLC25A44 EPM2A PIPOX SULT2A1-4 KPNB1 PFKFB2 PFKFB1 PFKFB4 PFKFB3 CYP19A1 ACAT2 ACAT1 SLC9A1 DSEL PMVK THEM5 THEM4 HACL1 SRD5A2 SRD5A1 SRD5A3 B3GALT4 B3GALT6 B3GALT5 GGCT SLCO1A2 UST SLC25A2 COX4I1 COX4I2 FHL2 PIK3CD PIK3CG NADK2 DSE ME1 ME3 ME2 UPP1 ARNT NDUFC1 SLC25A15 SLC25A18 SLC25A17 SLC25A19 RPL13A-1 SLC25A10 SLC25A12 SLC25A4 SLC25A11 ST6GALNAC5 SLC25A14 SLC25A13 ST6GALNAC6 NDUFB9 NDUFB8 NDUFB7 NDUFB6 PPM1L LRP1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HSD17B13 HSD17B12 PPM1K LRP2 HSD17B11 LRP8 HSD17B10 SLC25A27 CKMT2 SLC25A28 PCBD1 SLC25A21 D2HGDH IARS1 SLC25A20 SLC25A22 NDUFA9 CYB5A NDUFA8 NDUFA7 NDUFA6 MMAA MMAB NDUFA4 NDUFA3 RPL23A DHODH SLC25A37 TMLHE NT5C1A SLC25A32 AHCYL1 TXNDC11 NUBP1 NUBP2 ACAD11 ACAD10 PTGR1-1 ARSA ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 ASRGL1 PPP1R3C STX1A MMADHC GCDH PIK3R3 PHYH-4 PIK3R6 PIK3R5 ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSG RIMKLA RIMKLB HMGCLL1 CTSA SURF1 ADHFE1 TPTE;TPTE2 PAICS ACER2 ACER1 TH RPL27A ACER3 RGL1 MOGAT3 MOGAT2 MOGAT1 TECR AKR1B1 WASL HSCB ARV1 SPTLC1 ACADL SPTLC3 HYAL2 MLX CD38 ACADM ACADS AASS ACAD8 VKORC1 STARD3NL ACAD9 AKR1A1 NT5C1B;NT5C1B-RDH14 CYP2J2-1 INPP1 AKR1D1 RXRB GCH1 PLEKHA1 NUBPL PLEKHA2 GCGR ACAA1-1 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PPP1CA SULT1B1-1 PLEKHA8 ALDH4A1 ACAA2 EHHADH-1 CPOX CYP46A1 DUOXA1 DUOXA2 SBF1 GGT1 SBF2 G6PD MAT1A DPEP2 DPEP1 ATP5MC2 ATP5MC3 FUT2 FUT1 FUT4 ATP5MC1 EBP FUT7 FUT9 CYP11A1 CYC1 NDUFV3 NDUFV2 NDUFV1 GGT5 FDPS GGT7 GGT6 SLC52A3 QDPR GCLC GCLM CHD9 DNPH1 GPHN GAPDH-1 CPT2 UQCRFS1 A4GALT SULT4A1 HS3ST3B1 BCKDHA GLRX5 BCKDHB ABHD14B DARS1 LMBRD1 NDUFS8 NDUFS7 NDUFS6 CHDH NDUFS4 NDUFS3 BLVRB NDUFS2 MVD NDUFS1 PNP-1 BLVRA PAOX MVK MAT2B SAMHD1 CYGB HMGCL MAT2A AK4-1 MBTPS1 RPIA CYP24A1 RPL26L1 MBTPS2 PNMT RPL4 GOT1-1 RPL30 RPL3 RPL32 RPL31 GLDC RPL34 ENO1 ENO2 RPL8 ENO3 RPL9 RPL6 ENO4 RPL7 FDXR PLCE1 CYP1B1 RPL35 PIP4K2A RPL38 PIP4K2B MMUT PIP4K2C RPL39 ACOT9 CUBN ACOT8 MECR ACOT7 RPL21 RPL23 GLCE RPL22 MED8 MED9 HOGA1 CLPS CKMT1A;CKMT1B FDX1 RPL24 NHLRC1 RPL27 HPRT1 RPL26 RPL29 RPL28 ACOT4 CHST11 CHST12 PNPO CHST15 SLC19A3 PLCG2 CHST13 CHST14 SLC19A1 SLC19A2 CDK19 MTHFR RPL3L FA2H SLC6A7 SLC6A8 OGDH CYP1A1 PLCH1 PLCH2 ADA RPLP1-2 ADK ADO SERPINA6 PFAS TMEM186 PIP4P1 IMPA1 IMPA2 RFK LDLRAP1 MIOX ITPK1 TIMM21 BAAT ITPKB TMEM177 ITPKC PLCB3 PLCB4 IVD ITPKA PLCB1 PLCB2 RRM2-1 OCA2 ASAH1 ASAH2 RPL11 RPL14 SC5D RPL13 RPL18 RPL17 RPL19 AOC3 AOC1 AOC2 TIMMDC1 FMO1 FMO2 NMNAT3 FMO3 NMNAT2 AGT FIG4 NMNAT1 FMOD PLCD3 PLCD4 PLCD1 CHRM3 CHPF AHR FABP12 ABHD10 MAEA NAGLU IYD CHP1 GYG2 GYG1 AIP CACNB2 CACNB3 CEMIP FECH GLO1 AK1 ASMT AK2 ITPR1 ITPR2 MRI1 ITPR3 AK5 ABHD5 CYP4F22 AK6 AK7 AK8 AK9 ESD PSAP ESRRA SLC37A1 ASNS DHCR24 TECRL ALB SERINC1 DHCR7 SERINC3 SERINC2 SERINC5 SERINC4 GADL1 RPL7A GM2A SLC37A4 AMN GPX1 UGT1A1;UGT1A6 GPX4 AMT SORD ADRA2C INMT ADRA2A SARS1 ASPA ACSS2 GLS2 TYRP1 GLRX ACSS1 KCNJ11 TXNRD1 RPL35A PTPN13 ASS1 PFKL MARCKS IMPDH1 IMPDH2 FOLR2 CDO1 PFKM MMACHC PFKP SLC46A1 FAAH HPSE2 ACSM3 ACSM1 GDE1 ACSM5 MTR-1 ACSM4 NADSYN1 CHAC2 CHAC1 PTGDS GLUL SACM1L CMC1 ACSL6 SLC6A12 ACSL5 SLC6A11 CMBL INPP4A CYP27A1 PLPP6 INPP4B OXCT1-1 VDAC1 PLPP3 PLPP2 ALDH7A1 PLPP1 PTGES ACY1;ABHD14A-ACY1 SMIM4 MAOB MTARC2 MAOA MTARC1 MGST3 MGST1 MGST2 INPP5B CYP27B1 DGUOK SGPL1 INPP5A INPP5F NDUFC2;NDUFC2-KCTD14 INPP5D INPP5E INPP5J NAALAD2 INPP5K SCAP ASL TRAP1 CBLIF CIDEA ALOX15B ACADSB STAR STAB2 HCCS GYS2 GYS1 GLIPR1 QARS1 AUH NNT GUK1 ANKRD1 TNFAIP8L1 TNFAIP8L3 FFAR1 TNFAIP8L2 DLAT MANBA NME2 AMPD1 NME3 AMPD2 AMPD3 NME1 NME6 B3GNT7 B3GNT5 B3GNT4 FAM20B B3GNT3 B3GNT2 ALDOC ALDOB ALDOA UMPS PPA1-1 SPAM1 COX7A2L-1 ALOX12B UQCR11 AKAP5 UQCR10 ARNTL ATP5F1A ATP5F1B CA12 ARNT2 OLAH NQO1 NQO2 SCD5 RANBP9 FAH ATP5F1C LYVE1 ATP5F1D CA14 PSPH CA13 SPNS2 OCRL DCTD ALDH3A1 OXA1L CMPK1 ABCG2 COX7A2 ADIPOR1 ADIPOR2 HSPA9 ACBD7 ACBD6 ACBD4 EPHX1 TMEM126A-1 AZIN2 ACSF3 NMRAL1 ACSF2 MAN2B2 MAN2B1 ABCD4 B4GALT2 B4GALT3 ACADVL ABCD3 SLC2A1 SLC2A2 DHTKD1 SGSH ALDH2 CA5B PLCZ1 CA5A KYNU NAPRT CYP4V2 AOX1 MAN2C1 TSHB HIBCH PSTK ABCC3 ABCC1 ABCC2 PTGIS ABCC8 DCXR ABCC5 MARS1 CTPS2 CTPS1 HPDL HKDC1 PXYLP1 LALBA B4GALT6 B4GALT7 B4GALT4 B4GALT5 PON3 PTGES3-1 HPGD PON2 GMPR2 PON1 PRELP LTC4S RMND5B RMND5A BPNT1 B3GAT3 B3GAT2 B3GAT1 SGPP2 SGPP1 POMC PIKFYVE GNPDA1 GNPDA2 ALOX5AP SCLY PIAS4 UBE2I VDR NR1H2 RORA RXRA SUMO2 PPARG PPARA MINPP1 ECHS1 CPS1 ARG1 TP53 OTC LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 PLA2G2A-1 LIPI LIPH JMJD7-PLA2G4B;PLA2G4B CPNE3 MFSD2A DGAT2 MIGA2 PCYT2 MIGA1 DGAT1 STARD7 CSNK2A2 GPD1L-1 PISD PLA2G15 ABHD3-2 GNPAT PHOSPHO1 GPD2 GPD1 CSNK2B PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 CHAT PLD4 PLA2G3 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT CDS2 SLC44A5 ACHE SLC44A3 HADHB-1 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A PLA2G4D PLA2G4E PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 GPCPD1 PLAAT4 HADHA PITPNM1 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 MGLL PLA2G1B AGPAT1 AGPAT2 ALPG;ALPP;ALPI-1 SELENOI AGPAT3 AGPAT4 GPAT4 AWAT2 GPAT3 GPAT2 CEPT1 CDIPT PLA2G10;LOC100652777 PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 LPIN1 LPIN2 LPIN3 PNPLA2 PLCG1 PPP1CB PRKACA-1 PPP2R1A HSP90AA1 UBA52 PRKAR2B RPS27A UBB;UBC CTRB1;CTRB2 PHYKPL HSPG2 BCAN CTSV;CTSL DCN CD44 ACAN PRSS3;PRSS2;PRSS1 LIPE PDK4 MED1 ACSL1 MED4 MED6 MED7 PEX11A CCNC-1 PPARGC1A PPARGC1B CREBBP CIDEC MED16 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 NCOA6 ELOVL5 NCOA3 MED27 MED23 NCOR2 NCOR1 MED24 MED20 PLIN2 ANGPTL4 PLIN1 GPS2 FABP4 MED31-1 EP300 ADIPOQ TBL1XR1 LPL MED30 MORC2 CDK8 SIN3A ACSS3 SMARCD3 HDAC3 SCD ERCC2 THRSP PDZD11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 MCCC2 SLC5A6 BTD PC PCCA HLCS MCCC1 PCCB ACACB ACACA AKT1 NUP214 PRKCA MAPKAPK2 GNAS-1 ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A B4GAT1 NUP107 NUP188 NUP210 NUP93 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NMT1 NMT2 NUP62 NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 NUP42 NUP43 RAE1 RANBP2 NUP35 RAN NUP37 IDUA HEXB NCAN HEXA BGN GLB1L3 GLB1L2 VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB DNM2 PPP2CB;PPP2CA PPP2R5D PPP2R1B PIK3R2 PIK3CB PIK3R1 PIK3CA CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 ALOX5 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 SDC4 SAR1B SDC2 SDC3 PIK3R4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 PARP16 PARP14 PARP10 RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 PARP6 PARP4 PARP9 PARP8 RPS27L RPS15A GPC1 RPS3 GPC3 GPC2 GPC5 GPC4 RPS2 GPC6 SEC24D-1 FAU AGRN RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TKFC CAV1 HSP90AB1 RPS4X RPS3A PIK3C3 SEC23A SEC24B SEC24A SEC24C CALM3;CALM1 GNGT1 SPHK1 GAPDHS GBA GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 GALE B4GALT1 ST3GAL6 PANK4 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT ACSL4 ACSL3 ABCD1 GCKR GCK RAP1A APOB NDST2 NDST1 SCP2 NDST4 NDST3 GSTK1 PRKAB2 SDS TSTD1 SECISBP2 CACNA2D2 PHKA1 PHKA2 CH25H MTHFD1 SCO1 MTHFD2 SCO2 LARS1 FAR1 FAR2 TMEM126B CLOCK SHMT2 SHMT1 CIAO3 CIAO1 RDH11 AGMO AFMID PIP5K1A PIP5K1B LTA4H PIP5K1C GSTM4 GSTM3 PRXL2B SFXN4 LGMN MTMR10 MTMR12 KCNC2 MTMR14 DPYS MED19 PRKAG2 MED15 MED18 SMPD3 MED11 SULT1C2 SMPD2 SMPD4 ATIC SMPD1 TSPO ENOPH1 CHST6 CHST7 GSTO2 SPHK2 GSTO1 MED26 MED29 PGM2L1 SLC7A5 MED22 MED25 SDHAF2 CYP21A2 SDHAF3 MED21 AGPS SDHAF1 DPYD CHST1 ACSBG1 SDHAF4 L2HGDH ACSBG2 CHST2 RAPGEF3 PPARD RAPGEF4 CHST3 SAMD8 OAT GSTP1 ODC1 DLST ABCB11 RIDA RPL12-1 KCNB1 BBOX1 GID4 GID8 CIAPIN1 CRAT KCNG2 SLC27A1 ALDH1L1 ALDH1L2 FADS2 UROD NUDT19 NEK1 NUDT16 NUDT15 NUDT13 FADS1 NUDT12 TPST2 ACLY TPST1 SMS SLC27A3 SLC27A2 SLC27A5 UQCRB GMPS GMPR GSTT1 NRF1 NPAS2 NDOR1 AMDHD1 PGK1 KDSR IP6K1 NADK IP6K3 IP6K2 AGXT2 UROS BMX G6PC1 UCKL1 G6PC2 G6PC3 UQCRQ SP1 OGN TBXAS1 ACO1 ADSS1 ACO2 HPSE ADSS2 OSBPL1A SNAP25 ALAS2 ALAS1 PTEN APIP ETFA ETFB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ALAD SPR PGM2 ACP5 PGLS UGT2A1 PGM1 CERS3 CERS4 CERS5 CERS6 FOLH1B;FOLH1 RRM2B BCAT1 AGXT FXN DCTPP1 SMIM20 CERS1 TNFRSF21 BCAT2 CERS2 PRPS2 PRPS1 PRKAA2 CARNMT1 NME4-1 ACSM2A;ACSM2B FOXRED1 SRM SRR AWAT1 PHKG1 PHKG2 SLC36A4 TSPOAP1 MID1IP1 CYP4B1 GSTZ1 SUCLA2 UROC1 NAGS DMGDH SLC23A2 CERK SLC23A1 ECI1 NUDT5 NUDT3 HYKK STS BPNT2-1 PPAT MFSD2B GALM-2 OMD TALDO1 BCS1L SLC52A1;SLC52A2 CYP39A1 PYURF PPA2 TRIB3 CES3 CES2 CES1 PTGS2-2 SLC45A2 NEU2 NEU3 BRIP1 APOM NEU1 B4GALNT1 APOE PCK1 DECR2 B4GALNT2 PCK2 DECR1 DMAC2L SLC10A1 SLC10A2 MED13L EXT1 AIMP1 BST1 CYP26A1 EXT2 AIMP2 ALDH6A1 NDUFAF6 EPRS1 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 KYAT3 NDUFAF3 KYAT1 NDUFAF1 GSTA3;GSTA5;GSTA1;GSTA2 NDUFS5-1 LDHAL6B ACY3 COX7B HIBADH CROT COX7C KHK THTPA NMRK2 NMRK1 PHGDH COX8A SREBF1 COX8C GAA SREBF2 APRT EEF1E1 AGL-1 AHCY MRPS36 HSD17B3 HSD17B4 FITM1 FITM2 CYP2C18-1 COX5B HSD17B7 HSD17B8 COX5A GNAI1 CYP17A1 GNAI2 HSD17B1 ORMDL2 HSD17B2 ORMDL3 XDH PNPLA7 ORMDL1 GCG COX6C CYP8B1 NUDT7 KCNS3 NDUFAB1 NUDT4;NUDT4B PNPLA4 PNPLA5 PNPLA6 CBR1-1 GDA TACO1 INPPL1 MSMO1 COX6A1 COX6A2 TXN2 AKR7A2 AKR7A3 PPIP5K1 PPIP5K2 ENPP6 COQ10A-1 ENPP7 ACOT11 ACOT12 ACOT13 SDHC SDHD KMO SDHA COX6B2 SDHB COX6B1 SHPK SULT6B1 COX19 UBIAD1 NNMT NDUFB10 COX15 NDUFB11 COX18 COX17 CACNA1A CACNA1D GLYAT CACNA1C HIGD1A CACNA1E AANAT DHRS7B COX11 COX14 COX10 SYT5 EEFSEC PDHA1 HIGD2A NAT1 DEGS1 DEGS2 COX20 GALK1 TNFAIP8 PODXL2 TAT ADAL TMEM223 CA1 CYP26B1 ACOXL AKR1B15;AKR1B10 CA3 CA2 CA4 CA7 CA6 CA9 CAD ACOX2 ACOX3 NAT8L FBP1 FBP2 GALT NAXE SLC3A2 PPOX NT5C2 GK2 POLD1 TGS1 CRYM HSD3B7 RRM1 FAHD1 HS3ST5 HS3ST6 SUOX HS3ST4 TTC19 HS3ST1 HS3ST2 GALC GALNS CYP11B1;CYP11B2 CARM1 SARDH NAXD GLA PI4K2B CDA XYLT2 XYLT1 GLS NAMPT GAMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARMC8 MTAP PRKD3 HMBS PRKD2 PRKD1 ADPRM PI4K2A TPH2 TPH1 SDSL GNS ADH5 ACMSD LDHB ADH4 LDHA TTPA HMOX1 ST3GAL5 CGA HMOX2 LHPP FDFT1 NR1D1 MCAT SQLE RPL5-1 TCN2 ADI1 TCN1 PAH PPT1 MMS19 PPT2 FUT6;FUT5;FUT3 ITPA PYGB GPI MOCS2 MOCS3 PYGM GPT PYGL CSAD MCEE TK2 TK1 RAB5IF TPI1 COQ10B GCHFR MTF1 PLIN3 AHRR TKT GART MED28-1 WDR26 SGMS1 SGMS2 PAPSS2 PAPSS1 CYP2A13;CYP2A6;CYP2A7-1 SLC17A5 CKB LDLR CKM TPK1 RNLS GSS GLYCTK MOCOS SQOR PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds PODXL2 SLC35D1 TPST2 MGST3 SLC35D2 TPST1 MGST1 UGP2 MGST2 MAT2B N6AMT1 GSTT1 TPMT MAT2A UXS1 HPGDS AS3MT ABHD10 SULT2A1-4 GSTA3;GSTA5;GSTA1;GSTA2 GSTK1 BPNT1 UGDH AHCY GGCT ESD UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GSTM4 UGT2A1 AKR1A1 GSTM3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 GSTA4 UGT1A1;UGT1A6 GLYATL3 SULT1C2 COMT CNDP2 SULT1B1-1 ACSM2A;ACSM2B TRMT112 GSTO2 GSTT2B;GSTT2 GSTO1 GGT1 MAT1A GSTZ1 CYP1A2 GSTA3;GSTA1 ACSM1 ACSM5 BPNT2-1 SULT6B1 MTR-1 GGT5 ACSM4 MTRR NNMT GGT7 CHAC2 GGT6 CHAC1 GSTP1 GCLC GCLM GLYAT OPLAH SULT4A1 ABHD14B NAT1 GSTM1;GSTM2-1 GSS SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis DDC AANAT TPH2 TPH1 ASMT INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes HSP90AB1 TXN APP NLRC4 RELA MEFV BCL2 NFKB2 HMOX1 PANX1 PYCARD P2RX7 PSTPIP1 BCL2L1 AIM2 CASP1 TXNIP NLRP1 SUGT1 NFKB1 NLRP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model SLC25A14 UCP1 SLC25A27 UCP3 UCP2 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 SKP2 UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation LARS1 MARS1 AIMP1 KARS1 SARS1 EEF1E1 AIMP2 EPRS1 AARS1 HARS1 RARS1 YARS1 WARS1 GARS1 DARS1 NARS1 FARSA CARS1 PPA1-1 TARS1 FARSB VARS1 QARS1 IARS1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 DOCK7 GAB1 MET RAP1A RAPGEF1 CRK CRKL RAC1 RAP1B HGF NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes NOTCH1 EGF PDGFA MAFK AREG NFE2L2 BCL2 CREBBP BCL2L1 EP300 SP1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) NSDHL DHCR24 HSD17B7 SREBF1 SREBF2 CYP51A1 MSMO1 TM7SF2 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA PTPN6 PTPN11 BTLA TNFRSF14 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 EEF1B2-1 EEF1G EEF1A1 EEF1D EEF1A2 EEF2 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation FGFBP1 FGFBP3 FGF22 FGF3 FGF10 FGF1 FGF2 FGF7 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border BMP4 CTNNB1 TCF7L1 WNT3A DLX5 POU5F1;POU5F1B PAX3 TFAP2A SOX2 PAX7 TFAP2C FGF4 ZIC1 MYB MSX1 TFAP2E;TFAP2B INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) TSC1 AKT2 AKT3 AKT1 TSC2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism RPS14 ASRGL1 RPS17 GNMT RPS16 AGMAT MARS1 GCDH RPS19 GATM RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 RIMKLA RIMKLB RARS1 DIO1 SDS DIO3 TSTD1 SECISBP2 TH RPL27A PSMD12 PSMD11 PSMD14 LARS1 PSMD13 SCLY TPO PSMA7 PSMD8 SHMT1 PSMB6 PSMB7 PSMD6 RPS25 AFMID RPS27 PSMB4 GCSH-3 PSMD7 RPS29 AASS ACAD8 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PSMB1 PSMD1 RPL36AL-1 AMD1 ADRM1 AZIN1-2 PSMC2-1 PSMA2-1 FTCD PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 ALDH4A1 PSMC4 ENOPH1 PSMC1 MCCC2 DUOXA1 DUOXA2 TST ALDH9A1 MCCC1 SLC7A5 MAT1A RPS27L RPS15A RPS3 BCKDK UBA52 PSAT1 RPS2 CTH MTRR OAT QDPR ODC1 CBS;CBSL DLST RPL18A FAU RIDA RPL12-1 RPS27A SEPHS2 BBOX1 CRAT RPS9 BCKDHA RPS7 RPS8 BCKDHB RPS5 DARS1 RPS6 RPSA SLC22A4 CHDH SMS PAOX PRODH;LOC102724788 PYCR1 PYCR2 PYCR3 TYR HAL AMDHD1 RPL26L1 PNMT RPL4 GOT1-1 RPL30 AGXT2 RPL3 BHMT2 CAV1 RPL32 RPL31 GLDC RPL34 PHYKPL RPL8 HAAO HDC RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A DUOX1 APIP RPL39 DUOX2 RPL21 RPL23 RPL22 HOGA1 FOLH1B;FOLH1 CKMT1A;CKMT1B BCAT1 RPL24 AGXT RPL27 RPL26 RPL29 RPL28 BCAT2 RPL15-1 CARNMT1 HGD SRM SRR RPL3L SLC36A4 SLC6A7 SLC6A8 MPST OGDH GSTZ1 UROC1 NAGS DMGDH RPLP1-2 ADO HYKK GLUD1;GLUD2 SEPSECS GRHPR DAO PXMP2 IVD DBH SLC45A2 OCA2 DBT RPL11 RPL14 PRODH2 RPL13 RPL18 DCT RPL17 RPL19 AOC1 DDC FMO1 DDO AIMP1 AIMP2 ALDH6A1 EPRS1 IL4I1 KYAT3 TDO2 KYAT1 IYD HIBADH ETHE1 ASMT PHGDH IDO2 HPD MRI1 IDO1 EEF1E1 AHCY MRPS36 RPL10;RPL10L-1 ASNS OAZ1 SERINC1 SERINC3 SERINC2 SLC5A5 SERINC5 SERINC4 GADL1 RPL7A HAO1 AMT BHMT INMT SARS1 ASPA RPLP0 GLS2 TYRP1 RPLP2 TXN2 TXNRD1 RPL36-1 RPL35A ARG2 ASS1 CDO1 SIRT5 KMO DLD MTR-1 GOT2-1 NNMT KARS1 GLUL SLC6A12 GLYAT SLC6A11 CARNS1 AANAT EEFSEC AADAT ALDH7A1 TAT RPL22L1 HNMT SAT1 NAALAD2 RPL37A-1 SLC25A44 NAT8L ASL PIPOX SLC3A2 ACADSB ACAT1 CRYM QARS1 AUH SUOX SARDH SLC25A2 ECHS1 CPS1 ARG1 GLS TP53 OTC GAMT MTAP SLC25A15 TPH2 RPL13A-1 TPH1 SLC25A10 SDSL SLC25A12 ACMSD SLC25A13 NQO1 CGA FAH PSPH RPL5-1 ADI1 PPM1K PAH HSD17B10 CKMT2 PCBD1 SLC25A21 IARS1 GPT CSAD AZIN2 NMRAL1 RPL23A TMLHE DHTKD1 TXNDC11 SLC44A1 SLC44A2 PAPSS2 PAPSS1 KYNU CKB CKM TSHB HIBCH PSTK RPS15 SQOR SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 NGF STAT3 NTRK1 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2-2 ALOX5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RAB5A PRKACA-1 DOCK7 MAFK RAC1 DOCK1 MYB HBG2;HBG1 KDM1A JMJD1C DOCK10 DOCK11 KIF5B KIF5A KIF21A CDK2 KIF21B PRKAR2B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B ZFPM2 ZFPM1 GATA6 GATA5 AK3 GATA4 GATA2 KLC1 GATA1 PHF21A KLC4 KLC3 KLC2 RACGAP1 KIF3B MICAL1 KIF3C CARMIL1 NFE2 EHD1 ABL1 EHD2 KIF18A EHD3 KIF18B MAFG MAFF RCOR1 CBX5 DOCK6 PRKAR1B GATA3 DOCK5 PRKAR1A DOCK4 CDK5 DOCK3 DOCK9 DOCK8 KIF12 KIF11 KIF15 AKAP10 KIF19 CAPZB KIF13B HMG20B KIF1C KIF1B PRKACB-1 KIF3A KIF1A JAK2 PRKAR2A KIF25 KIF23 SIN3A KIF22 RBSN KIF6 KIF27 RAD51B KIF9 RAD51C KIF2A KIFC2 KIFC1 IRF1 IRF2 KIF2C KIF2B DOCK2 HBD;HBB AKAP1 CDC42 MFN1 MFN2 TP53 SH2B3 SH2B2 SH2B1 CABLES1 CABLES2 CENPE WEE1 KIF26A CAPZA1 KIF26B CAPZA2 HDAC2 IFNB1-4 HDAC1 VPS45 ITPK1 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion TREH GUCA2B CEL GUCA2A LIPF CHIT1 PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B SI LCT PNLIP ALPG;ALPP;ALPI-1 CLPS GUCY2C PNLIPRP1 MGAM RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation NOS2 HGS ATP6V1H UBB;UBC CORO1A RAB7A RAB5A KPNB1 VPS33B KPNA1 RPS27A UBA52 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling TYK2 CA1 ARF1 P4HB RPLP0 GSTO1 GSTA3;GSTA5;GSTA1;GSTA2 PITPNA LMNB1 CNN2 HNRNPDL AIP CFL1 STAT4 IL12B JAK2 IL12A HSPA9 IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF RALA-1 SOD2 TALDO1 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 CDC42 LCP1 PPIA MTAP JAK1 TCP1 CAPZA1 RAP1B REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity FBXL17 BACH1 SKP2 UBB;UBC CUL1 MAFK RBX1 SKP1 RPS27A UBA52 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC36A4 SLC7A9 SLC7A5 SLC3A2 SLC6A12 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC7A1 SLC1A7 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes PDK4 KAT8 MED1 ACSL1 HCFC2 MGLL MED4 MED6 MED7 AGPAT2 HCFC1 WDR82 PAXIP1 PEX11A CCNC-1 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PPARGC1B CREBBP SETD1B SETD1A CIDEC TADA2A ZZZ3 H2AC20 GPAM H2AB2;H2AB3;H2AB1 PHF20 LPIN1 ASH2L SGF29 MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 NCOA6 ELOVL5 NCOA3 MED27 SIRT1 MED23 PHF20L1 NCOR2 KAT2B H2AJ KAT2A NR5A2 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC5 AJUBA MCRS1 H2BC1 FABP4 MED31-1 EP300 PHLDA1 MEN1 BOD1L2;BOD1 H2AC4 ADIPOQ TBL1XR1 KMT2D KMT2A KMT2C KMT2B BOD1L1 LPL MED30 ABL1 MBIP TASP1 DR1 CDK8 CDK5 YEATS2 TADA3 AKAP8L PSIP1 DPY30 PAGR1 H2BC21 WDR5 RXRA KDM6A H2AZ2;H2AZ1 CEBPA ACSS3 HDAC3 DGAT2 CXXC1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 KANSL2 SCD KANSL3 THRSP RB1 LIPE H2AC14 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors NMNAT3 MMADHC BST1 NMNAT2 NMNAT1 ST20-MTHFS;MTHFS PDZD11 SLC25A51;SLC25A52 SLC5A8 THTPA NMRK2 MTHFD1 NMRK1 MTHFD2 SHMT2 SHMT1 PARP16 PARP14 PARP10 CD38 PARP6 PARP4 CYB5R3 AMN PARP9 QPRT PARP8 MCCC2 SLC5A6 GSTO2 BTD GSTO1 PC PCCA HLCS MCCC1 PCCB ACACB ACACA FOLR2 MMACHC SLC46A1 MTR-1 MTRR NADSYN1 NNMT SLC52A3 PANK4 FLAD1 PANK3 GPHN PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 ALDH1L1 PPCS ALDH1L2 FASN ENPP2 ENPP1 LMBRD1 SLC25A42 MTHFD2L ENPP3 AASDHPPT NUDT12 CTRB1;CTRB2 CD320 NADK CBLIF SLC22A13 NAXE DHFR2;DHFR MMUT NT5E NAXD MTHFD1L CUBN NADK2 ACP5 NAMPT SLC25A19 PNPO SLC19A3 SLC19A1 SLC19A2 MTHFR TCN2 TCN1 LRP2 SLC23A2 SLC23A1 MOCS2 MOCS3 RFK CYB5A LDLRAP1 MMAA ABCD4 MMAB SLC52A1;SLC52A2 SLC2A1 SLC25A32 PRSS3;PRSS2;PRSS1 NAPRT AOX1 TPK1 RNLS ABCC1 MOCOS PDXK ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2R1B DUSP4 PPP2R1A DUSP3 MAPK7 VRK3 DUSP6 MAPK1 DUSP7 MAPK3 PPP2CB;PPP2CA PPP2R5D CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response IL10 ADAM17 IL6 FURIN MAPK14 CD163 PLK2 RHBDF2 MYH9 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 AKT2 AKT3 CSNK2A1;CSNK2A3 CCNA2-1 CCNA1 PRKAB2 SCO2 SFN NLRC4 CASP1 YWHAE PRMT1 PRKAG2 PPP2R1A YWHAG G6PD YWHAB AKT1 UBA52 TSC2 TSC1 YWHAZ AURKA CCNB1 RPS27A UBB;UBC MAPK14 MAPK11 CENPJ CDK1 TXN PMAIP1 BID BBC3 YWHAQ YWHAH PIP4K2A PDPK1 PIP4K2B PTEN PIP4K2C RRM2B CCNK PRKAA2 CCNT1 SUPT16H GTF2F1 GTF2F2 PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B ELL ELOC-1 BRIP1 TAF7L CCNE2 ELOA CCNE1 NELFB ELOB CCNH NELFCD EHMT2 NELFA EHMT1 NELFE CTDP1 TAF9 POLR2A PLK2 COX7B POLR2B POLR2C MDC1 CREBBP COX7C ATF2 POLR2D TP53RK NOC2L SGK1-1 POLR2G KAT5 TAF9B CHEK2 COX8A POLR2I CHEK1 TP63 COX8C DAXX HUS1 TAF15 PRKAB1 RRAGA TAF12 RRAGC TAF13 RRAGB TAF10 DDIT4 TAF11 RRAGD SSRP1 DNA2 RHNO1 PHF20 TAF8 E2F4-1 TCEA1 L3MBTL1 TAF7 MEAF6 COX5B MAPKAP1 PRDX2 TAF6 NUAK1 COX5A TFDP1 TAF5 PCBP4 TAF4 PRDX1 TFDP2 TAF3 TP53BP2 ATRIP TAF2 PRELID3A TAF1 BANP BARD1 PLK3 PRELID1 CRADD E2F1 GADD45A TPX2 COX6C RAD17 JUN ATM CDK12 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM GLS2 BRCA1 PRKAG3 RPTOR COX6A1 ING5 COX6A2 ING2 TXNRD1 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 MBD3 RAD51D BRPF3-1 PCNA WRN COX6B2 PLAGL1 PERP COX6B1 PMS2 GTF2H1 RICTOR GTF2H3 BRD7 GTF2H4 TIGAR GATAD2B RPA1 GATAD2A RPA2 MLH1 HIPK1 CDK2 PPP2CB;PPP2CA POU4F1 POU4F2 CYCS-1 HIPK2 TTC5 RPA3 EP300 CCNG1 PPP2R5C RAD1 PPP2R1B LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 CDK7 STK11 FANCI CDK5 BRPF1 CNOT10 FANCC CNOT4 MNAT1 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CHD4 CNOT1 CHD3 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 CASP6 TBP PPP1R13L MLST8 CARM1 CASP2 TOPBP1 COX4I1 ZNF385A COX4I2 RFC5 RFC3 RFC4 APAF1 GLS TP53 RFC2 RABGGTB RABGGTA RBL2 PRDM1 RBL1 BIRC5 TMEM219 PRKAA1 GTF2H2C;GTF2H2C_2;GTF2H2 RNF34 AURKB COX7A2L-1 TP53INP1 HDAC2 RBBP8 RFFL E2F7 E2F8 HDAC1 ARID3A PML MTOR TNRC6C RAD50 MOV10 BAX CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 TNRC6B FAS POLR2E CSNK2B TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A POLR2F POLR2H RBBP7 MTA2 POLR2L COX7A2 GPI ERCC3 ERCC2 CDK5R1 NDUFA4 CDKN2A CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism SLC6A7 GAMT SLC6A8 GATM CKB CKM CKMT2 CKMT1A;CKMT1B SLC6A12 SLC6A11 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE TLR3 CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes MORF4L1-2 SUPT7L BRMS1 KAT6B MORF4L2 HAT1 ENY2 TAF5L KDM4C-1 ATXN7 EP400 SMYD3 DMAP1 COPRS MRGBP RIOX2 TADA1 BRWD1 KDM5A KDM5B KDM5C VPS72 KDM6B MSL2 H2BC18 MSL1 KDM7A KDM3A KDM3B HDAC8 KDM4A KDM4B KDM4D USP22 MSL3-1 REST CLOCK NFKB2 PRMT1 PAX3 RPS2 KDM1A PHF21A RCOR1 HMG20B JAK2 SMARCB1 EHMT2 EHMT1 H2AC14 SAP130 KAT8 SMARCC1 SMARCC2 HCFC1 TAF9 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP ATF2 SETDB1 SETD1B KAT5 SETD1A SMARCA2 SMARCA4 TADA2A ZZZ3 H2AC20 TAF12 H2AB2;H2AB3;H2AB1 TAF10 EZH2 PHF20 SUV39H1 MEAF6 ASH2L SGF29 NCOA1 NCOA2 ACTL6A NCOR2 KAT2B H2AJ KAT2A ING5 NCOR1 AEBP2 PRMT5 BRD1 GPS2 MBD3 SUZ12 BRPF3-1 H2BC5 MCRS1 H2BC1 GATAD2B GATAD2A CDK4 ARID4B EP300 H2AC4 SAP30 TBL1XR1 KMT5A KMT2D KMT2A KMT2C KMT2B KAT6A SMYD2-1 MBIP SUDS3 DR1 BRPF1 YEATS2 ACTB-1 TADA3 MECOM DPY30 CHD4 CHD3 H2BC21 WDR5 KDM6A EED DNMT3A CARM1 H2AZ2;H2AZ1 ARID1A ARID1B SMARCD1 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC1 MTA1 HDAC10 RBBP4 TRRAP EPC1 RBBP5 SUPT20H SAP30L PRDM7;PRDM9 WDR77 JMJD6 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PADI3 CCND1 PADI2 SAP18 PADI4 PADI1 PADI6 RBBP7 PRDM16 MTA2 TADA2B MTA3 PHF2 SUV39H2 SMARCE1 SETD2 ATF7IP SETD3 SETD6 SETD7 H2BC15;H2BC3;H2BC11;H2BC12 PHF8 KANSL1 ING4 ING3 KANSL2 PRMT6 PBRM1 KANSL3 PRMT7 ACTL6B PRMT3 ASH1L SUPT3H TAF6L DOT1L RELA NSD3 NSD1 NSD2 BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 H2AC16;H2AC11 ELP6 KDM1B NFKB1 JADE1 ARID4A YEATS4 JADE3 JADE2 RUVBL2 RUVBL1 KMT5B ARID2 KDM2A KDM2B KMT5C ARID5B INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 BUB1B CDC23 CDC20 CDC26 CDC27 ANAPC7 BUB3 UBE2C MAD2L1 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35D1 SLC25A4 SLC35D2 ARL2 PDZD11 SLC5A6 SLC35B3 SLC35B2 SLC35B4 LCN15 SLC35A1 LCN12 APOD SLC35A2 SLC35A3 SLC33A1 SLC35C1 ARL2BP LCN1 SLC27A6 SLC29A4 SLC28A2 SLC25A5 SLC29A1 SLC28A1 SLC29A3 SLC27A1 SLC27A4 SLC29A2 SLC28A3 SLC25A6 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 ARHGAP35 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A PTPN13 DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 CAV1 DSG1 PKP4 RBMX EPHA2 PICALM PIK3R2 PIK3R1 CKB DDX4 ROCK1 TNFAIP1 RASAL2 ARHGAP5 RND3 ARHGAP21 MUC13 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins HPGD LTA4H ALOX5 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor BAX NELFB NTRK3 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC9A2 SLC9A3 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 ADD3 GJA1 UACA GNA13 TRA2B STOM PTK2B BUB1 CLASP2 SPEN LIMK2 LIMK1 HSPE1 FMNL3 SLC4A7 FMNL1 PPP1CC FMNL2 VIM PIK3R4 SFN RPS27 YWHAE CCP110 PPP1CB MAPRE1-1 DOCK7 LBR PPP2R1A YWHAG HSP90AA1 PPP1R12A CKAP5 VAPB PAFAH1B1 DYNC1I2 KDM1A DOCK10 DOCK11 KIF5B KIF5A VCP-1 CLASP1 KLC1 DYNC1H1 TIAM2 NDE1 KLC4 PLK1 KLC3 KLC2 RACGAP1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CDH1 CAPZB CAV1 ACBD5-1 HSP90AB1 KIF2A YWHAQ YWHAH PDPK1 KIF2C KIF2B DOCK2 CDC42 MFN1 MFN2 PIK3C3 CENPE VHL KLK3;KLK2 HGS CALM3;CALM1 RAB7A LMNB1 CFL1 PAK2 CCT2 DBT CCNE1 SLC1A5 H2AC14 CCT7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCT6A MYH9 MTMR1 H2AC20 H2AB2;H2AB3;H2AB1 IQGAP1 NCOA2 CDKN1B ARHGAP35 RAC1 H2AJ ARAP1 RHOA ELMO2 DOCK1 H2BC5 H2BC1 MEN1 LAMTOR1 H2AC4 STEAP3 LETM1 CDC25C ABL1 ACTB-1 SRRM1 DDX39B PIN1 H2BC21 H2AZ2;H2AZ1 BIRC5 AURKB H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 TIAM1 RAPGEF1 MAPK1 MAPK3 FRS3 S100A9 S100A8 SOS1 PIK3R3 KDM4C-1 BUB1B CDC20 BUB3 MAD2L1 WASL SHMT2 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F CTNNB1 LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 YWHAB PKP4 RBMX EPHA2 PICALM XPO1 PRKCD PRKCA YWHAZ ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MAPK14 MYLK PREX2 MAPK11 PREX1 WDR91 ANKFY1 CEP97 PRKCB FNBP1 STARD8 NDUFS3 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 WDR81 DAAM1 NGEF CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR RHOT1 MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 GMIP LRRC41 CIT INCENP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 CENPA FGD1 CENPC FGD2 FGD3 CUL3 LMAN1 FGD4 RASAL2 FGD5 CHN2 CHN1 FLNA STX5 YKT6 CENPT FARP2 FARP1 NUP107 CENPU USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 CENPF CENPH ABI2 TAOK3 CENPI TAOK1 SHKBP1 CENPK ABI1 CENPL CENPM GOPC FILIP1 AAAS PKN2 CENPO PKN1 CENPP NUP160 NUP85 CENPQ UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 CLIP1 PHIP MAD1L1 RHOBTB3 LIN7B RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 DVL3 PLXNA1 SEC13 ABL2 SRGAP3 SRGAP2 NUP133 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 RANGAP1 NSFL1C ARPC2 ARPC3 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 NCK2 SPDL1 NCK1 PLEKHG3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 NUP43 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK RANBP2 DSG2 EVL PPP1R12B PFN2-1 SOS2 ROCK2 SRC SRF ROPN1;ROPN1B NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF2 WASF3 NUP37 RNF20 PPP1R14A PCDH7 CDC42BPB BAIAP2 CDC42BPA MYO19 PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 BTK PFN1 CFTR GRB7 TMEM87A PTPN13 GARRE1 TWF1 KALRN MYL12B DSN1 SCFD1 SPTBN1 SCAI RCC2 STAM ZWINT CLTC PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 MTR-1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 PPP2CB;PPP2CA RAC3 SPTAN1 GIT1 PPP2R5B NDEL1 PPP2R5A VAV3 PPP2R5D CCDC115 PPP2R5C RALBP1-1 PPP2R1B RHOG RHOH RHOF PPP2R5E CDC37 RHOC RHOD ERBIN VAV1 VAV2 RHOB CTTN RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU TAX1BP3 ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ITGB1 ARHGEF6 AMIGO2 WAS NOXO1 TRAK1 TRAK2 PAK1 PGRMC2 SAMM50 EMC3 CTNNA1 PAK3 DYNC1I1 PAK5 PAK4 BCAP31 GIT2 CAVIN1 MTX1 MYO9B MYO9A MPP7 DLC1 TRIP10 RAB9A JAG1 B9D2 ESYT1 SPC24 RAB9B SPC25 TJP2 AR ERCC6L RTKN PRAG1 ZWILCH BUB1B-PAK6;PAK6 ARHGDIG ARHGAP39 PMF1;PMF1-BGLAP ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 ARHGDIA PIK3R2 ARHGDIB KNTC1 ARHGEF40 CYBB PIK3R1 CYBA ARHGAP45 SGO1 ALDH3A2 SGO2 STAM2 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 FRS2 ARHGEF28 ARHGAP19 PIK3CA ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 NCKIPSD ARHGAP22 ARHGAP20 MYH14 HMOX2 MYH11 RHPN2 ECT2 MYH10 CPSF7 ARHGEF39 ARHGAP29 MACO1 OCRL ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP DLG4 ACTR3-1 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 PLIN3 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 CKB ALS2 PEAK1 PDE5A ITGB3BP CCDC187 RAP1GDS1 MOSPD2 ARHGAP11A-1 FAM169A DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells TPST2 GATA3 HDAC11 BMI1 ETS1 TNF YY1 IL4R HDAC4 DPY30 KLF13 CHD4 RING1 CHD3 IL13 MAF IRF4 CREBBP CCL3L1;CCL3L3;CCL3;CCL18 HDAC5 HDAC8 SATB1 HDAC9 NOTCH1 RNF2 HDAC6 HDAC7 TBX21 STAT6 SMARCA4 RBPJ WDR5 CBX8 STAT5A STAT5B CBX6 PHC2 PHC1 POU2F1 CBX4 MAML2 CBX2 MAML1 NFATC2 NFATC1 ASH2L POU2F2 PHC3 BATF IL4 IL5 MAML3 NOTCH2 HDAC2 HDAC3 HDAC1 JUN SNW1 MAMLD1 MTA1 HDAC10 RBBP4 NCOR2 RBBP5 KAT2B KAT2A NCOR1 RUNX3 RUNX1 RBBP7 MTA2 MTA3 FOS STAT4 MBD3 IL12RB2 GATAD2B GATAD2A IFNG EP300 MEN1 TBL1XR1 KMT2A NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration ACO1 IDH1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine NAGK AMDHD2 GFPT2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling SPATA2 TNFAIP3 SHARPIN TBK1 USP21 USP4 MIB2 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 BIRC3 CASP8 OPTN-1 RIPK1 FADD TNF IKBKE RNF31 XIAP USP2 OTUD7B FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex HDAC1 TRRAP RBBP5 CTNNB1 H2AJ TCF7 CDC73 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TERT LEO1 BCL9L TLE4 RUNX3 TLE3 TLE2 TLE1 TCF7L1 AXIN2 PYGO1 DPY30 BCL9 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PYGO2 H2BC15;H2BC3;H2BC11;H2BC12 CREBBP H2BC5 H2BC21 H2BC1 KAT5 LEF1 SMARCA4 WDR5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 TCF7L2 ASH2L MEN1 H2AC4 RUVBL1 MYC KMT2B H2AC14 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP5 AQP2 AQP3 LOC100509620;LOC112267859;AQP7 AQP1 MIP AQP8 AQP10 AQP9 AQP6 AQP11 AQP4 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 GSK3B PRKACB-1 CSNK1A1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 GLI2 PSMA5 PRKACA-1 SEM1 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TBK1 TANK TICAM2 LY96 TICAM1 OPTN-1 TRAF3 RPS27A CD14 UBB;UBC TLR4 IKBKE UBA52 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes CSF1 IFNG N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi LHB MGAT4C MGAT4B CGA B4GALT6 FUT8 B4GALT4 B4GALT5 MAN2A1 ST6GAL1 MGAT5 FUT6;FUT5;FUT3 ST3GAL4 MGAT2 MGAT4A-1 MAN2A2 MGAT3 B4GALT2 ST8SIA6 B4GALT3 CHST10 CHST8 B4GALT1 ST8SIA2 FUCA1 ST8SIA3 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 TRAF6 NOD1 NOD2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 CHUK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway CSNK2A1;CSNK2A3 HDAC11 BMI1 YY1 RING1 MAF HDAC5 HDAC9 RNF2 HDAC6 HDAC7 CBX8 GPAM CBX6 PHC2 PHC1 CBX4 CBX2 NFATC2 PHC3 NFYA-1 ERBB2 EGFR YWHAE PRKACA-1 LBR PPP2R1A YWHAG SKP1 TCF7 UBA52 CUL1 AURKA CCNB1 RPS27A UBB;UBC MEF2C CENPJ SPI1 TGIF1-1 CDK1 ZNF287 ZNF18 RBFOX1 RBFOX3 BCL2L11 TXN ZNF282 ZNF10 ZNF12 CLDN5 PMAIP1 DDIT3 ZNF23 BID ZNF25 BBC3 GRIN2A ZNF268 ZNF263 ABCA6 NR2F1 NR0B2 GRIN2B NR2F6 COL1A1 INS;INS-IGF2 COL1A2 ZNF496 ZNF250 UCMA ZNF45 HEY1 HEY2 ZNF41 CTLA4 ZNF248 ZNF485 ZNF483 ZNF235 ZNF473 SERPINB13 ZNF470 HTT ZNF226 ZNF222 CR1L;CR1 ATAD2 ZNF77 ZNF79 SKI ZNF70 AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 NFYB RORC RORB NFYC ZNF689 ZNF205 ZNF446 ZNF688 ZNF445 PITX2 ZNF202 ZNF200 ZNF160;ZNF347;ZNF665-1 ZFP69B CTSK FOXP3 NPAS4 ZNF432 PVALB BLK GRIA2 MAX DLX6 FOXO4 FOXO3 CTSV;CTSL ATXN3 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 SOCS4 ZKSCAN1 ZNF662 ZNF660 FBXO32 ZNF419 MMP13 ZNF658 ZNF416 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 FURIN ZKSCAN7;ZNF852 PPM1A HAND2 ITGA5 SPP1 PPM1D YAP1-1 ZNF624 ZNF621 E2F5 E2F6 ZNF747;ZNF764 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 RB1 ZNF613 SMARCB1 STUB1 CCNH EHMT2 PTPN4 EHMT1 TRIM33 UXT LGALS3 CCN2 H2AC14 TRIM28 ZFP1 ZNF713 ZNF711 ZNF710 L3MBTL2 FOXG1 TGFA ZNF707 MED1 ZNF706 SMARCC1 ZNF704 SMARCC2 ZNF703 HIVEP3 WWTR1 YES1 MED4 IQSEC3 MED6 ITGBL1 MED7 MSTN HNF4G FOXO1-1 SATB2 ZFP14 RXRG ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GAD1 GAD2 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CCNG2 PPARGC1B ZFP28 CREBBP IHH ZNF274;ZNF74 ZNF382 CCND3 CCND2 NPPA SETD1B MSX2 SETD1A GEM SMARCA2 GPRIN1 SMAD2;SMAD3 SMARCA4 ZFHX3 AUTS2 IL2 IL3 H2AC20 ZNF30 BMP2 LDB1 H2AB2;H2AB3;H2AB1 MYBL2 EZH2 RBM14 CBX3-1 TGIF2 ELF1 PHF20 ELF2 CAT RETN ASH2L ZNF804B MED16 ZNF175 MED17 SERPINE1 MED12 JUNB MED14 RNF111 MED13 ZSCAN25 MED10 ZNF157 ZNF398 ZNF394 NKX2-5 NR2C2AP ZNF383 ZNF140 CDC7 NR1D2 ACTL6A ZNF699-7 ZNF135 ZNF133 RARG MED27 BTG1 ZNF568-3 SIRT1 UBE2D3-1 MED23 RSPO3 TEAD1 TEAD2 NCOR2 TEAD3 KAT2B ZIK1 H2AJ TEAD4 KAT2A TCF12 PAX5 NCOR1 MED24 TAL1 RARB ZNF599 ZNF114 MED20 ZNF597 ZNF112 OCLN-1 ZIM2 ZNF584 GPS2 ZNF583 PCGF6 MBD3 ZNF582 CDKN2B SUZ12 H2BC5 PCGF5 PCGF2 WWP1 SIRT3 H2BC1 RYBP ZNF669;ZNF670 ZNF334 GTF2H1 ZNF573 GTF2H3 ZNF570 GTF2H4 CSF2 GATAD2B ITGA2B GATAD2A ZFP30 ZNF569 ZNF567 MED31-1 ZNF566 ZFP37 ZNF331 ZNF565 CYCS-1 ZNF563 IGFBP1 EP300 PF4;PF4V1-1 ZNF302;ZNF181 NRBP1 MEN1 ZNF311 ZNF793 ZNF792 H2AC4 ZNF791 KRBA1 ZNF549 ZNF548 TBL1XR1 ZNF317 ZNF546 ZNF354A;ZNF354B-4 ZNF304 ZNF786 KMT2D SKIL PLXNA4 KMT2A ZNF300 KMT2C ZNF782 KMT2B ESRRB ESRRG ZFP69 MED30 CDK6 ZNF777 ABL1 ZNF775 ZNF426-1 ZNF774 ZNF772 ZNF324B;ZNF324 ZNF771 ZNF770 ZNF529 ZNF521 CBX5 CDK8 ZNF75D CDK7 ZNF75A STK11 CDK5 ZFP90 CRH ZNF514 ZNF750 MNAT1 ZNF746 ZNF740 GSK3B KCNIP3 KLF4 RAD51 ZNF606 DPY30 ZNF605 CHD4 SOX9 CHD3 ZNF839 ZNF555;ZNF57;ZNF556 TWIST2 CITED1 SIN3B CITED2 SIN3A CITED4 H2BC21 PARP1 GP1BA ZNF649 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 NPY WDR5 CAMK4 LMO1 ZNF197;ZNF660-ZNF197 TBP LMO2 EED ATP1B4 LIFR KCTD6 H2AZ2;H2AZ1 ZNF124-4 ARID1A COX4I1 NOP2 ARID1B COX4I2 ZNF264;ZNF805-1 SMAD1 SMAD4 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 THRA ARNT SMARCD1 NR2E1 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 OPRM1 SMARCD2 CAMK2B CAMK2D HDAC2 CAMK2A SMARCD3 NR2C2 HDAC3 THBS1 HSPD1 HDAC1 HES1 CAMK2G ZNF189 ZNF286A ZNF184 ZNF180 RBBP4 OPRK1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2L SMARCE1 DEK H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 NDUFA4 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RXRB ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 G6PD YWHAB XPO1 AKT1 YWHAZ MAPK14 MAPK11 GLI3 GLI2 RBX1 ITCH PIP4K2A PIP4K2B PIP4K2C MED8 CCNK CCNT1 SUPT16H GTF2F1 GTF2F2 NEDD4L PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B RRM2-1 ELL ELOC-1 TAF7L ELOA NELFB ELOB NELFCD NELFA NELFE CTDP1 TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TCEA1 ESRRA TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GLS2 TXNRD1 FKBP5 PPP2CB;PPP2CA AXIN1 PPP2R5C PPP2R1B RET GATA3 HNF4A JAG1 PRDM1 MYC COX7A2L-1 ARNTL TNRC6C MOV10 ARNT2 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 COX7A2 TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 AKT2 AKT3 POMC SFN NLRC4 CASP1 TXNIP SKP2 PRMT1 MET TCF7L1 DLX5 SOX2 MYB TSC2 TSC1 STAT1 TJP1 ZFPM1 GATA4 GATA2 GATA1 NFE2 IRAK1 CAV1 YWHAQ YWHAH PDPK1 PTPN11 CALM3;CALM1 SOD2 IFNG CCNE2 CCNE1 PLK2 MDC1 ATF2 TP53RK NOC2L SGK1-1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 MAML2 RHNO1 MAML1 E2F4-1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 TFDP1 NUAK1 PCBP4 PRDX1 TFDP2 TP53BP2 ATRIP MAML3 PRELID3A NOTCH2 NOTCH3 BANP BARD1 NOTCH4 PLK3 PRELID1 E2F1 CRADD GADD45A TPX2 RAD17 JUN ATM SNW1 CDK12 MAMLD1 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM BRCA1 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D BRPF3-1 PCNA WRN PLAGL1 PERP PMS2 SOCS3 RICTOR BRD7 PTPN1 TIGAR RPA1 RPA2 CDK4 MLH1 HIPK1 CDK2 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 FANCI BRPF1 CNOT10 FANCC CNOT4 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CNOT1 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA RBL2 RBL1 BIRC5 TMEM219 PRKAA1 TRPC3 RNF34 AURKB TP53INP1 RBBP8 RFFL E2F7 E2F8 ARID3A PML MTOR RAD50 BAX HDAC10 FASLG EPC1 PRDM7;PRDM9 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKCQ PRMT6 PBRM1 ACTL6B BDNF CDK5R1 GCK YEATS4 MAPK1 MAPK3 ARID2 CCNA2-1 CCNA1 KDM5B PRKAB2 HDAC8 SCO2 REST PRKAG2 MED15 MED26 MED25 KIT PPARD PRKCB G6PC1 SP1 PTEN RRM2B USP9X PRKAA2 BRIP1 APOE PCK1 COX7B COX7C COX8A SREBF1 COX8C SRC SRF COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR4A2 NR5A1 AR RXRA SUMO1 RARA CARM1 PGR PPARG PPARA TP53 GLS NAMPT GAMT CSNK2A2 CGA NR1D1 CSNK2B GPI COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis TIMMDC1 NDUFS2 NDUFS1 NDUFAF6 NDUFC2;NDUFC2-KCTD14 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 NDUFS5-1 HSCB TMEM126B ACAD9 SFXN4 NDUFC1 NUBPL NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 NDUFB9 NDUFB8 NDUFB7 ECSIT NDUFB6 FOXRED1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 OXA1L HSPA9 TMEM186 NDUFV3 NDUFV2 TMEM126A-1 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFB10 DMAC2 NDUFA6 NDUFB11 NDUFA3 PYURF NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 LYRM2 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes ARNTL CLOCK CRTC1 CIPC TFEB PER2 PER1 NPAS2 DBP NR1D1 BHLHE40 CRY2 CRY1 SIK1;SIK1B RBM4;RBM4B RORC CREBBP KMT2A RORA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP TRNT1 HSD17B10 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway SDC4 SDC2 SDC3 GP1BA HSPG2 APP SDC1 SERPINE1 ANO6 ANO5 SMPD1 SERPINE2 GPC1 ITGB3 PROS1 F13A1 GPC3 SERPINA5 THBD GPC2 CD177 GPC5 FGB FGA GPC4 GP1BB F2R FGG GPC6 F2 F3 ITGA2B F5 F7 PROCR F8 ADAMTS13 VWF F9 SERPING1 SERPINC1 KNG1 SERPIND1 AGRN PF4;PF4V1-1 F10 F12 F11 GP5 GP9 PROC F13B KLKB1 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling SLC25A4 SLC25A14 UCP1 SLC25A27 PM20D1 UCP3 UCP2 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 XPO1 UBA52 NUP214 GTF2H1 GTF2H3 GTF2H4 RPS27A UBB;UBC CDK7 MNAT1 TBP PPIA GTF2H2C;GTF2H2C_2;GTF2H2 CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 SUPT16H NUP210 POLR2E POLR2F GTF2F1 POLR2H GTF2F2 NUP93 CHMP4C CHMP4B POLR2L CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 ERCC3 GTF2E2 NUP160 NUP85 TPR ERCC2 NUP88 SUPT4H1-1 NUP155 FURIN VTA1 NUP153 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 CHMP2A NMT2 TAF4B ELL ELOC-1 TAF7L NUP62 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE NDC1 SEC13 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins EIF2AK2 PIAS4 TOPORS SUMO1 RELA PIAS3 SUMO3 IKBKE UBE2I IKBKG NFKB2 NFKBIA PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage HPRT1 ADAL PNP-1 APRT DGUOK GMPR AMPD1 AMPD2 AMPD3 GMPR2 DCK ADA ADK CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase CALM3;CALM1 ADCY1 ADCY8 PRKX PRKACB-1 PRKAR2B PRKAR1B PRKAR1A PRKAR2A PRKACA-1 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON MUC3A MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 NOTCH1 MUC17 C1GALT1 MUC5B MUC20 MUC21 B4GAT1 LFNG DAG1 LARGE1 ADAMTS16 POMGNT1 ADAMTS18 NOTCH2 NOTCH3 NOTCH4 ADAMTS4 ADAMTS5 MUC13 THBS1 ADAMTS1 ADAMTS8 ADAMTS9 ADAMTS13 POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication RPS14 RPS17 NUP133 RPS16 RPS19 RPS18 NUP50 POM121;POM121C NUP54 RPS11 RPL10A RPS10 RPS13 RPS12 POLR2A NUP42 POLR2B POLR2C RPL27A POLR2D NUP43 POLR2G POLR2I RAE1 RANBP2 IPO5 GRSF1 DNAJC3-1 RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 NUP35 RPS21 RPS24 RPS23 RPL36AL-1 NUP37 RPL7A RPLP0 HSP90AA1 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 NUP214 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 PARP1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 RPL15-1 NUP210 POLR2E POLR2F GTF2F1 RPL3L RPL5-1 POLR2H GTF2F2 NUP93 POLR2L NUP205 RPLP1-2 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 POLR2J;POLR2J2;POLR2J3 RPL23A NUP62 RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 NDC1 RPS15 SEC13 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 MUS81 C1orf112 EME1-1 BRCA2 RAD51AP1 DNA2 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 PALB2 SPIDR BRIP1 SLX1A;SLX1B MRE11 NBN BARD1 RBBP8 RTEL1 SEM1 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action CUL1 IFIT1 IFIT3 IFIT2 SKP1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) VPS37C VPS37D VPS37A VPS37B CHMP3 CHMP6 CHMP7 CHMP5 HGS VPS4B CHMP4C VPS4A CHMP4B CHMP4A VPS28 TSG101 STAM MVB12B MVB12A UBA52 VTA1 CHMP2B RPS27A CHMP2A UBAP1 UBB;UBC VPS36 SNF8 VPS25 STAM2 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport STOM PDZD11 SGK1-1 ATP8A2 ATP8A1 ATP12A ANO8 BEST2 ANO9 BEST3 ANO6 SLC9C2 BEST1 ANO4 BEST4 ATP6V1E1 ATP6V1E2 ANO5 ATP6V1G1 ANO2 ATP6V1G2 ATP11C ATP11B ANO3 ATP1B2 ANO1 ATP11A ATP1B1 SLC9B1 SLC9B2 SCNN1G CLCA4-1 SCNN1D SCNN1B SCNN1A RAF1 ATP6V0D1 ATP6V0D2 ATP6V1A TTYH3 TTYH2 ANO10 WNK4 NALCN ASIC4 UBA52 ASIC5 WWP1 CLCA2 ATP6V0A2 CLCA1 ATP6V0A4 ASIC2 ATP6V1D ASIC3 ATP6V1C1 ATP6V1F ATP6V0A1 ASIC1 ATP6V1C2 ATP8B4 ATP8B3 ATP8B2 ATP8B1 RPS27A ATP4B ATP4A FXYD4 FXYD3 UBB;UBC WNK1 FXYD1 WNK3 FXYD6 CUTC RYR1 RYR2 TCIRG1 RYR3 UNC80 CLCNKA;CLCNKB ATP7B CLIC2 ATP6V0B TSC22D3 TRDN ASPH ATP6V1B2 ATP6V0C ATP6V1B1 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 CLCN3 CLCN2 CLCN1 BSND SGK3;C8orf44-SGK3 ATP6V1G3 ATP9B ATP9A ATP1B3-1 ATP13A1 FXYD2;FXYD6-FXYD2 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 ATP6V0E2;ATP6V0E1 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 CAMK2B TRPC1 CAMK2D TRPV2 CAMK2A TRPV3 TRPV1 MCOLN1 TRPC4AP CAMK2G MCOLN2 TRPV6 TRPV4 TRPV5 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI ATP6V1H CALM3;CALM1 NEDD4L ATP6AP1 ATP7A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) CGN F11R FKBP1A PARD3 TGFB1 PRKCZ RPS27A PARD6A RHOA SMURF1 TGFBR1-1 ARHGEF18 TGFBR2 UBB;UBC UBA52 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection GNG10 GNAS-1 GNG2 ADCY9 GNG5 GNG4 PRKAR1B PRKAR1A GNG8 YES1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 CD163 ADCY5 PLK2 GNG13 RHBDF2 PRKACB-1 MYH9 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 ADAM17 ITPR2 GNB5 ITPR3 CD3G CYSLTR1 CYSLTR2 GNAT3 SYK FGR HCK ADORA2B GNAI1 GNAZ PLCG1 GNAI3 GNAI2 FCGR3A;FCGR3B FYN FCGR1A PRKACA-1 PLCG2 GGT1 CALM3;CALM1 DPEP2 DPEP1 LYN IL10 GNGT1 GGT5 FURIN PRKAR2B AHCYL1 IL6 PRKX MAPK14 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 FGF20 FRS2 GAB1 SOS1 PPP2R1A FGF23 PIK3CA PTPN11 FGF2 UBA52 GALNT3 CBL PPP2CB;PPP2CA RPS27A UBB;UBC PLCG1 MAPK1 HRAS PIK3R1 BRAF MAPK3 FGF1 MKNK1 FRS3 FGF4 SPRY2 FGF16 NRAS FGF9 FGF18 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation FGF22 FGF3 TGFBR3 FGF10 GIPC1 FGF1 FGF2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism DGAT2 FABP3 FABP5 DGAT1 PPP1CA FABP6 PNPLA4 FABP7 PNPLA5 MGLL GPD2 PPP1CC FABP12 GPAT2 CAV1 PLIN1 GK2 PRKACB-1 MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP4 GPAM PLIN3 AGMO LPIN1 LPIN2 LPIN3 GK FABP9 FABP1 PPP1CB LIPE FABP2 PRKACA-1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 SLC38A1 GLUL ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU FURIN MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein GSK3A GSK3B PARP9 SUMO1 UBE2I PARP8 PARP16 PARP6 PARP14 PARP4 PARP10 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism BDH2 BDH1 HMGCS2 HMGCLL1 OXCT1-1 HMGCL AACS ACSS3 ACAT1 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs IQGAP1 MEN1 CLIP1 CALM3;CALM1 CDH1 CTNNB1 RAC1 IQGAP2 IQGAP3 CDC42 CTNNA1 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation ST3GAL4 MGAT4A-1 MGAT4C MGAT4B B4GALT2 ST8SIA6 B4GALT3 B4GALT1 ST8SIA2 B4GALT6 ST8SIA3 B4GALT4 B4GALT5 ST6GAL1 MGAT5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly CDK1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 NEK9 NEK6 AAAS NEK7 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 CCNB2 CCNB1 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1-1 AKT2 AKT3 AKT1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry HSPG2 GPC6 FURIN AGRN CTSV;CTSL VCP-1 SDC1 TMPRSS2 NRP1 GPC1 ACE2 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR FDXR FDX1 CYP11A1 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling AREG TGFA CDKN1B BCL2 AKT2 AKT3 SRF FOXO3 CCND1 ELK1 EREG BTC EGF EGFR MAPK1 MAPK3 FOS HBEGF PTK2 UHMK1 XPO1 EPGN AKT1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism SLC35D2 EXT1 IDS EXT2 CTSV;CTSL NDST2 NDST1 NAGLU NDST4 NDST3 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 HPSE2 GPC4 HS3ST5 HSPG2 GPC6 HS3ST6 HS3ST4 HPSE HS3ST1 HS3ST2 HS6ST1 HS3ST3A1 HS6ST2 HS6ST3 EXTL2 AGRN SGSH SDC1 HS2ST1 HS3ST3B1 EXTL3 GLCE IDUA GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis DTNBP1 TPD52L1 PUM1 AP4B1 IGF2R NECAP1 GOLGB1 YIPF6 ACBD3 PIK3C2A ARF1 OCRL CPD PICALM AP4E1 ARRB1 CLINT1 AP1G1 FTH1 AP1S2 DNM2 VAMP2 AP1S1 AP1S3 SH3D19 SH3GL2 TPD52 AP1B1 VAMP7 AP3B1 AP3S2;AP3S1 VAMP8 GAK DNAJC6 NAPA RAB5C TFRC TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 HSPA8 BLOC1S3 SNX9 AP1M2 SNX5 TXNDC5 AP1M1 TBC1D8B FTL-1 SNAPIN SORT1 HIP1R THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis TPO DUOX1 CGA DUOXA1 DUOXA2 TXNDC11 DUOX2 IYD DIO1 CAV1 DIO3 SLC5A5 TSHB DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 SFTPB SFTPC CSF2RB CSF2RA SFTPD RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 NUMA1 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling ARHGEF6 GNG10 PIK3R6 GNG2 PIK3R5 GNG5 AKT2 GNG4 AKT3 PAK1 GNG8 BTK RHOA GNG13 GNB2 GNB1 AKT1 GNB4 GNB3 GNGT1 GNB5 PDPK1 PLCB3 CDC42 PLCB1 PIK3CG PLCB2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling SOCS3 STAT1 ADAM17 PTPN6 PTPN1 STAT5A STAT3 STAT5B IRS1 MAPK1 CISH IRS2 MAPK3 PRL PRLR GHR JAK2 LYN SOCS2 SOCS1 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis COQ3 COQ2 STARD7 PDSS2 HPDL PDSS1 COQ8A COQ9 COQ7 COQ6 COQ5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling GNG10 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNAT2 PRKCG PSMD12 GNB4 WNT5B GNB3 RYK-1 PSMD11 ITPR1 WNT5A PSMD14 ITPR2 ROR1 PSMD13 GNB5 ROR2 ITPR3 LEF1 NLK PPP3R1 WNT1 PSMA7 FZD1 PSMD8 FZD3 FZD2 FZD5 PSMB6 FZD4 PSMB7 PSMD6 FZD7 FZD6 PSMB4 PSMD7 FZD8 NFATC1 PARD6A GNAO1 PSMB5 CLTB PSMB2 ARRB2 PSMB3 PSMD2 PPP3CA PSMD3 PPP3CB PRKG1 PSMB1 PSMD1 PRICKLE1 PDE6B PDE6A ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKG2 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 SCRIB PSMC1 CTNNB1 RAC1 TCF7 PFN1 RHOA VANGL2 TCF7L1 CLTC CLTA UBA52 AP2A1 AP2B1 AP2A2 PRKCA AP2S1 RAC3 RPS27A UBB;UBC MAP3K7 PRKCB DAAM1 WNT11 WNT4 SMURF2 SMURF1 CAMK2A TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B CALM3;CALM1 GNGT1 PLCB3 TCF7L2 PLCB1 PLCB2 DVL1 DVL2 DVL3 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation GJA1 CLTB MYO6 DNM1 DNM2 DAB2 CLTCL1 CLTC CLTA RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription RUNX1 GPAM AXIN1 KCTD6 ESR1 CBFB DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) TPST2 RUNX3 RUNX1 TBX21 TNF IFNG STAT4 CCL3L1;CCL3L3;CCL3;CCL18 NFATC1 IL12RB2 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease DLD BCKDHA PPM1K DBT BCKDHB NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants ALK P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response MDM2-2 CCNA2-1 CCNA1 MDM4 PSMD12 CHEK2 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 ZNF385A PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PCBP4 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 UBA52 CDK2 RPS27A CDKN2A UBB;UBC CCNE2 CCNE1 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport DYNLT2B IFT57 KIF17 DYNC2H1 HSPB11 IFT140 DYNC2LI1 IFT74 DYNLT5 WDR35 DYNLT2 IFT80 IFT20 IFT88 IFT22 IFT43 IFT81 TTC30A;TTC30B TRIP11 IFT27 DYNLRB2 DYNLRB1 IFT46 CLUAP1 KIF3A TTC21B TNPO1 WDR19 IFT122 KIFAP3 IFT172 DYNC2I2 DYNC2I1 KIF3B TTC26 TRAF3IP1 IFT52 KIF3C SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha NR1H4 G0S2 MED13L NR1H3 FAM120B AGT MED1 ACSL1 MED4 MED6 AHR MED7 PEX11A CCNC-1 PPARGC1A PPARGC1B CREBBP RGL1 SREBF2 CLOCK ABCB4 ACADM ESRRA MED16 MED17 NFYA-1 MED12 MED14 MED13 MED10 CD36 RXRB NCOA1 NCOA2 MED19 NCOA6 MED15 NCOA3 ABCA1 MED18 HMGCS2 MED11 MED27 MED23 APOA2 NCOR2 APOA1 APOA5 NCOR1 MED26 MED24 TXNRD1 MED29 MED22 MED20 MED25 PLIN2 ANGPTL4 MED21 GPS2 MED31-1 CHD9 EP300 CPT2 CPT1A SLC27A1 TBL1XR1 TIAM2 FABP1 FADS1 MED30 HELZ2 CDK8 HMGCS1-1 NRF1 NPAS2 SULT2A1-4 TGS1 NR1H2 RORA GLIPR1 SP1 SIN3A ANKRD1 RXRA CYP7A1 ALAS1 CARM1 PPARG PPARA FHL2 ME1 MED8 NFYB MED9 ARNT NFYC GRHL1 SMARCD3 HDAC3 ARNTL TNFRSF21 ARNT2 FDFT1 NR1D1 CDK19 CYP1A1 MTF1 AHRR TRIB3 MED28-1 THRAP3 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets PPP2R1A MAPK7 PPP2CB;PPP2CA PPP2R5D ELK1 RPS6KA3 PPP2R1B RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 MEF2A DUSP6 MAPK14 DUSP7 MAPK1 MEF2C MAPK11 MAPK3 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma CYP1B1 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions DLG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM11 ADAM22 CACNG8 ADAM23 CACNG2 CACNG3 CACNG4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism HLCS MCCC1 PCCB ACACA MCCC2 BTD PC PCCA ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation HECTD1 HECTD2 ASB10 HECTD3 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXL16 CDC20 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 TRIM36 ASB7 TRIM37 ASB4 ASB5 ASB2 TRIM32 ASB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 MIB2 BTRC PSMC3 PSMA1 RBCK1 PSMC4 PSMC1 SKP1 FBXW11 UBA52 CUL1 RPS27A UBB;UBC UBE2V1 RBX1 UBE2N ITCH LRRC41 CUL3 VHL KBTBD7 FBXO32 NEDD4L TRIM63 FBXO4 FBXO6 FBXW4 FBXW10;CDRT1 FBXW5 FBXW7 FBXW9 ELOC-1 FBXW2 ELOB STUB1 SOCS1 FBXL3 FBXL5 RNF111 RBBP6 UBE2D3-1 UBA7 UBE2L6 HERC5 LRR1 WWP1 CCNF KEAP1 CBLB SOCS3 DCAF1 SH3RF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 TRIM21 FBXO7 FBXO9 HERC6 TRAIP-1 WSB1 FBXO2 RNF123 RNF126 HECW2 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B GAN PRKN RNF130 GPR75-ASB3;ASB3-1 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 KCTD6 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 SMURF2 UBE2E2 SMURF1 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RNF41 KLHL42 UBE2V2 CUL7 RNF34 CUL5 UBA6 UBA5 CUL2 UBR4 KLHL11 KLHL13 UBR1 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 CDC34 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBE2D3;UBE2D2 UBA1 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 UBE2D1 TRIM69 UNKL ANAPC10 DTX3L ANAPC11 PJA2 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 CDC27 RNF138-1 THOP1 ANAPC7 RNF213-2 MGRN1 UBE2C ASB13 UBE2E1 ASB14 RNF6 ASB11 UBE2S RNF7 CDC16 ASB12 ANAPC4 ASB17 ANAPC5 RNF4 ANAPC1 RCHY1 ANAPC2 ASB18 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin MAOA SLC6A4 ALDH2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis GBA AP3M1 STAT3 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 CCT6A DCAF7 CCT6B SKIV2L FBXL3 KIF13A FBXO4 FBXL5 LONP2 FBXO6 WRAP53 CCT3 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 FBXW7 TP53 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS FKBP9 HDAC3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion GNB3 GNGT1 GNB5 ADRA2C ADRA2A GNG10 GNG2 GNG5 GNG4 CACNA1D GNG8 CACNA1C GNAI1 GNAI2 ADCY6 GNG13 ADCY5 CACNB2 CACNB3 CACNA2D2 GNB2 GNB1 GNB4 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency GSS DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death BCL2L11 CDK5 CAPNS1 CAPNS2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CAPN2 CAPN1 CAST H2BC21 GOLGA2 RIPK3 CDC25A DNMT3B CDC25B APP PRIM2 PRIM1 MLKL H2AC20 POLA1 EED POLA2 H2AB2;H2AB3;H2AB1 DNMT3A GSDME H2AZ2;H2AZ1 EZH2 TP53 PRDX2 PRDX1 YWHAE JUN TRADD RBBP4 FASLG TRAF2 H2AJ CASP8 FOXO3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIPK1 FADD RBBP7 LMNB1 H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC1 CDK5R1 SOD2 C1QBP CDKN2A H2AC4 DNMT1 H2AC14 CDC25C FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism PTGIS PLA2G4A PHYH-4 HADHA ACSL1 PON3 PTGES3-1 HPGD PON2 SCP2 PON1 LTC4S PRKAB2 CROT TECR ALOX5AP HACD1 CYP4F22 ACADL HSD17B3 HSD17B4 ACADM ACADS LTA4H HACD3 TECRL HSD17B8 HACD2 PRXL2B HACD4 CYP2J2-1 PRKAG2 ELOVL5 GPX1 ACAA1-1 CYP8B1 GPX4 NUDT7 NDUFAB1 ACAA2 FAAH2 CBR1-1 EHHADH-1 GGT1 PCCA ELOVL1 PCCB DPEP2 ELOVL4 DPEP1 ACACA ELOVL2 ALOXE3 ACOT11 ELOVL3 ACOT12 ACOT13 ELOVL6 ELOVL7 PTGR2 FAAH ACSBG1 ACSM3 ACSBG2 GGT5 PPARD MAPKAPK2 PTGDS PTGS1 ACSL6 ACSL5 CPT2 CPT1A CRAT SLC27A1 CPT1B FASN FADS2 CYP2U1 NUDT19 PTGES ACSL4 ACSL3 FADS1 SLC22A5 ACLY SLC27A3 SLC27A2 ACOXL MORC2 PECR HPGDS ACOX2 ACOX3 ALOX15B ACBD5-1 THEM5 TBXAS1 THEM4 HACL1 RXRA CYP1B1 MMUT ABCD1 ACOT9 ECHS1 ACOT8 CBR4 MECR ACOT2;ACOT1 ACOT7 PTGES2 SLC25A17 ALOX12B ACOT4 OLAH HADH PRKAA2 SCD5 AWAT1 ALOX15 MCAT ALOX12 HSD17B12 MID1IP1 CYP2C9;CYP2C19 CYP4B1 EPHX2 PPT1 CYP1A1 ALOX5 CYP1A2 PPT2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ECI1 ACBD7 ACBD6 SCD ACBD4 SLC25A20 THRSP ACSF3 MCEE ACSF2 AMACR MMAA ACADVL HADHB-1 PTGS2-2 ACAD11 PCTP ACAD10 PTGR1-1 DECR2 DECR1 ABCC1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors CAMK2G MDM2-2 GRIA2 MYO6 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 PRKCG DLG4 PRKCA GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 CAMK2B CAMK2D CAMK2A PRKCB AKAP5 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors ADORA2B ADORA2A ADORA3 ADORA1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 FGF20 NCBP1 SOS1 FGF23 FGF2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I NCBP2-1 PLCG1 HRAS PIK3R1 TIAL1 FGF6 PTBP1 MKNK1 RBFOX2 SPRY2 ESRP2 HNRNPH1 NRAS ESRP1 FRS2 HNRNPA1-1 GAB1 TIA1 PPP2R1A PIK3CA HNRNPM PTPN11 POLR2E FGF7 FGFBP1 POLR2F FGFBP3 GTF2F1 POLR2H GTF2F2 FGF22 FGF3 FGF10 POLR2L UBA52 CBL PPP2CB;PPP2CA HNRNPF POLR2J;POLR2J2;POLR2J3 RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 MDM2-2 CTNNA1 CDH1 JUP PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BANP ADRM1 CTSS PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 CTSB CTSV;CTSL UBA52 DNM2 RPS27A UBB;UBC FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis ABL1 ARPC4 ARPC5 WAS ARPC2 LIMK1 ARPC3 PAK1 YES1 NF2 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A ITPR1 HSP90AB1 ITPR2 WASL ITPR3 ACTG1 CD3G CDC42 SYK FGR HCK PIK3R2 PIK3CB PLCG1 PIK3R1 FCGR3A;FCGR3B FYN WASF2 FCGR1A WASF3 BAIAP2 PIK3CA NCKIPSD PRKCE PLPP5 PLPP4 PLCG2 RAC1 MYO10 HSP90AA1 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 PLD4 CRK CFL1 DOCK1 PLD1 PLA2G6 LYN PTK2 PLD3 PLD2 PRKCD ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 AHCYL1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope DSP SPRR3 CSTA KLK5 PCSK6 EVPL CAPNS1 KLK8 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 JUP TGM1 CASP14 DSG1 LIPJ PKP4 SPRR1A;SPRR1B LIPN LIPM CAPN1 PRSS8 LIPK TGM5 ST14 PERP CDSN SPINK6 SPINK5 KLK13 KLK14 DSG2 FURIN KAZN CELA2B;CELA2A LCE6A PKP2 PKP1 LORICRIN DSG3 PKP3 SPINK9 DSG4 DSC1 IVL DSC2 DSC3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response UACA CASP3 BAX C1QBP GSDME APIP CYCS-1 CDKN2A APAF1 AVEN GSDMD DIABLO-1 CASP9 MAPK1 CASP7 BAK1 MAPK3 XIAP NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase PDE11A PRKG2 ITPR1 PDE10A KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 NOS1 PDE9A NOS3 NOS2 GUCY1A2 PDE5A GUCY1A1 GUCY1B1 PDE1B PDE1A PDE2A IRAG1 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere ACD TINF2 ATRX H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 POLR2E TERF2IP TERF1-1 POLR2F POLR2H POLR2L POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C H2BC15;H2BC3;H2BC11;H2BC12 POLR2D H2BC5 H2BC21 POLR2G H2BC1 POLR2I DAXX H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 POLR2J;POLR2J2;POLR2J3 H2AC4 H2AC14 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling GAB1 PIK3CA MET PIK3R1 HGF DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW3;OPN1MW2;OPN1MW;OPN1LW MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 SPDL1 NUP43 RANBP2 NSL1 RPS27 NUP37 MAPRE1-1 PPP2R1A KNL1 ZW10 DSN1 CKAP5 RCC2 ZWINT XPO1 AHCTF1 PAFAH1B1 DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E DYNC1H1 NDE1 PLK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SGO2 AURKB CENPS-CORT;CORT;CENPS CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPO NUP160 CENPP NUP85 CENPQ ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 CLIP1 MAD1L1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP SEC13 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals UNC5A DCC UNC5B PTPN11 UNC5C UNC5D NTN1 SRC PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy ATM MAP1LC3B2;MAP1LC3B-1 UBB;UBC NBR1 PEX5 USP30 SQSTM1 EPAS1 RPS27A UBA52 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism TAT HPD GSTZ1 HGD FAH SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction MPP5 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants FLT3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ZNF598 RPL27A ASCC2 RPL8 ASCC3 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 UBE2D3-1 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBE2D3;UBE2D2 UBA52 RPS2 UBE2D1 RPL18A RPL23A FAU RPL12-1 RPS27A UBB;UBC RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity AKT2 AKT3 CSNK2A1;CSNK2A3 NEDD4 PSMD12 PSMD11 TRIM27 PSMD14 USP13 PSMD13 TNKS TNKS2 RNF146 PSMA7 FRK OTUD3 PSMD8 PTEN PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CSNK2A2 PSMC3 PSMA1 PSMC4 PSMC1 WWP2 CSNK2B MKRN1 AKT1 UBA52 RPS27A UBB;UBC PREX2 STUB1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs CALM3;CALM1 CAMK1 CAMKK1 RAC1 GIT1 CAMKK2 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection ARPC4 ARPC5 GNG10 GNG2 ARPC2 GNG5 ARPC3 GNG4 NOXA1 GNG8 YES1 CD163 PLK2 GNG13 NCK1 RHBDF2 MYH9 GNB2 ACTR2 GNB1 GNB4 GNB3 ITPR1 WNT5A ITPR2 GNB5 ITPR3 WASL MEFV NFKB2 PYCARD P2RX7 PSTPIP1 FZD7 CASP1 TXNIP SUGT1 GNAI1 PLCG1 GNAI2 WASF2 WASF3 BAIAP2 PRKACA-1 JUN RAC1 MYO10 BTK MYO5A MYO1C GGT1 DPEP2 DPEP1 ELMO1 ELMO2 CRK DOCK1 PTK2 GGT5 PRKAR2B CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 GSDMD VAV1 VAV2 MAPK14 MAPK8 ABL1 TXN GNAS-1 WAS NOXO1 ADCY9 PRKAR1B PRKAR1A ACTB-1 ADCY4 ADCY3 NLRP3 NCKAP1L ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MYO9B PRKACB-1 NOX1 PRKAR2A ARPC1B ARPC1A ADAM17 HSP90AB1 NT5E ACTG1 C3AR1 CD3G IL18 CYSLTR1 IL1A CYSLTR2 IL1B CDC42 GNAT3 P2RX4 SYK FGR HCK ADORA2B GNAZ GNAI3 CYBA FCGR3A;FCGR3B FYN FCGR1A C3-1 NCKIPSD CTSG HMOX1 PLCG2 ABI2 CALM3;CALM1 ABI1 LYN IL10 GNGT1 ACTR3-1 FURIN RELA AHCYL1 NFKB1 IL6 PRKX MAPK1 MAPK3 ENTPD1 DVL1 ENTPD5 DVL2 DVL3 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism GLB1 ST6GALNAC5 ST6GALNAC6 ST3GAL5 ST8SIA5 CTSA ST6GAL1 ST3GAL4 ST6GALNAC2 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 ST8SIA6 ST8SIA2 ST8SIA3 ST6GALNAC1 CMAS NPL NEU2 NEU3 NANP ST6GALNAC3 NEU4 ST6GALNAC4 ST8SIA4 SLC17A5 NEU1 NANS ST6GAL2 ST8SIA1 GNE ST3GAL6 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling CD274 HDAC1 STAT3 PRDM1 IL2RG HIF1A DNMT1 HDAC2 EP300 SIN3A HDAC3 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC1 MCCC2 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) EIF4A3 CNOT10 CNOT4 KDM5A CNOT6 KDM5B CNOT7 KDM6B CNOT11 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CNOT1 CNOT2 CREBBP CNOT3 H2BC21 CNOT8 CNOT9 KDM6A H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 SRPK1 TP53 EIF4A2 BTG4 EIF4A1 TUT7 TUT4 DUXB UHRF1 DIS3L2 STPG4 DICER1 METTL23 DPPA4 DPPA3 DPPA2 ZFP36L2 AGO2 LEUTX HIRA H2AJ DUX4;DUXA TEAD4 EIF4E H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 EIF4B PAIP1 NPM2 AICDA TET3 H1-8 TNKS1BP1 TPRX1;RAX2 ZSCAN4 PABPN1-1 CNOT6L H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 YAP1-1 EP300 H2AC4 PABPC1;PABPC3 EIF4G1 H2AC14 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission KCNJ2 KCNJ12;KCNJ18 KCNJ3 GABRQ KCNJ4 GABRA2 GNG10 GABBR2 GABRA1 GNG2 KCNJ5 GNG5 GABBR1 GNG4 KCNJ6 KCNJ10 GNG8 GABRA6 GABRA5 KCNJ9 GABRA4 GABRA3 KCNJ15 RASGRF2 KCNJ16 GRIN1 GLRB APBA1 PRKAB2 GNG13 GNB2 GNB1 PRKCG GNB4 GNB3 GNB5 PRKAB1 SRC GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 GNAI1 GNAI2 PRKAG2 PRKACA-1 KIF17 PRKAG1 RAC1 PRKAG3 NRG1 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 PRKCA PRKAR2B GIT1 RPS6KA3 RPS6KA2 KPNA2 RPS6KA1 PRKCB MDM2-2 ADCY9 PRKAR1B PRKAR1A GRIN2A ADCY4 ADCY3 MYO6 GRIN2B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A CAMK4 PDPK1 CAMK1 CAMKK1 CAMKK2 GNAT3 HRAS GNAI3 PRKAA1 CAMK2B CAMK2D CAMK2A NRAS AKAP5 CAMK2G PRKAA2 GRIA2 CALM3;CALM1 RPS6KA6 CHRNB2 ACTN2 CHRNA2-1 CASK CHRNA1 CHRNB4 CHRNA9 CHRNA3 LIN7A CHRNB3 LIN7C CHRNA5 GRIN2C CHRNA4 GRIN2D CHRNA6 GRIN3B GRIN3A GNAL DLG2 DLG3 DLG4 GNGT1 NBEA GABRB3 GABRB2 GABRB1 GRIK5 RASGRF1 GRIK3 GRIK4 GRIK1 GRIK2 NRGN PLCB3 GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 PLCB1 NPTN PLCB2 NEFL HTR3A HTR3B LRRC7 LIN7B CHRNA7;CHRFAM7A PRKX MAPK1 PPM1E PPM1F MAPK3 NCALD GLRA1 CHRND GLRA2 GLRA3 CHRNG CHRNE REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development HES1 SNW1 MAMLD1 AKT2 AKT3 KAT2B KAT2A HNF4G FOXO1-1 INS;INS-IGF2 FGF10 ONECUT1 NEUROD1 NKX6-1 NKX2-2 PDX1 CREBBP PAX6 HNF1A MAFA AKT1 RFX6 IAPP NOTCH1 INSM1 PTF1A FOXA3 HNF1B NEUROG3 GCK FOXA2 RBPJ MAML2 EP300 MAML1 SLC2A2 MAML3 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC21 H2BC1 DNMT3B PRIM2 PRIM1 H2AC20 POLA1 EED POLA2 H2AB2;H2AB3;H2AB1 DNMT3A GSDME H2AZ2;H2AZ1 EZH2 H2AC4 DNMT1 H2AC14 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium CCT8 CCT5 CCT4 HDAC6 ARF4-1 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 NPHP1 NPHP3 MARK4 RAB11FIP3 ARL13B BBS2 BBS1 RAB3IP BBIP1 AHI1 CEP83 YWHAE CEP89 CEP57 C2CD3 CETN2 CEP164 PKD2 CCP110 PKD1 DYNC2I2 AKAP9-1 TCTN3 DYNC2I1 TCTN2 TTC26 MAPRE1-1 TCTN1 TRAF3IP1 PRKACA-1 BBS9 ACTR1A CNGA2 DYNLT2B KIF17 TUBA1A BBS7 PPP2R1A HSPB11 CNGA4 DYNC2LI1 CNTRL BBS5 CEP250 CC2D2A IFT74 NEK2 BBS4 DYNLT5 IQCB1 DYNLT2 IFT80 CEP290 MKKS IFT20 YWHAG EXOC8 IFT22 RAB8A EXOC7 KIF24 IFT43 CDK5RAP2 IFT81 SSTR3 TTC30A;TTC30B HSP90AA1 BBS10 BBS12 TRIP11 CEP135 IFT27 RP2 DYNLRB2 TMEM216 DYNLRB1 EXOC4 EXOC3 IFT46 HAUS4 EXOC6 CLUAP1 HAUS3 EXOC5 CSNK1D EXOC2 HAUS6 CNGB1 HAUS5 EXOC1 TUBG1 ASAP1 CKAP5 TMEM67 HAUS2 PDE6D TUBA4A RHO HAUS1 SEPTIN2 CEP63 GBF1 SCLT1 RAB11A TNPO1 PAFAH1B1 ATAT1 DYNC1I2 TTC8 DCTN2 CEP162 SSNA1 B9D1 DCTN3 HAUS8 PRKAR2B KIFAP3 HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 IFT172 TUBB4B CEP97 NEDD1 KIF3B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ KIF3C IFT52 ALMS1 CDK1 IFT57 DYNC2H1 TPTEP2-CSNK1E;CSNK1E IFT140 CEP41 RPGRIP1L CEP43 WDR35 IFT88 SMO INPP5E KIF3A TTC21B B9D2 WDR19 IFT122 MKS1 CCT3 CCT2 TCP1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes ATF4 MAFK NFE2L2 CREBBP EP300 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling NTF3 NTRK2 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide RPL10A RPL27A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 RPL10;RPL10L-1 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RPLP2 RPL36-1 RPL35A UBA52 ANKZF1 KLHDC10 NPLOC4 TCF25 UFD1 NEMF RPL18A RPL12-1 VCP-1 RPS27A UBB;UBC RBX1 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 LTN1 RPL9 RPL6 RPL7 RPL35 RPL38 RPL39 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 UBE2D3;UBE2D2 UBE2D1 RPL23A ELOC-1 RPL11 RPL14 RCHY1 ELOB RPL13 RPL18 RPL17 RPL19 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism MTR-1 LDLRAP1 MMADHC MTRR MMAA ABCD4 MMAB MMUT CTRB1;CTRB2 CUBN PRSS3;PRSS2;PRSS1 TCN2 CD320 CBLIF TCN1 LRP2 LMBRD1 MMACHC AMN ABCC1 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members WWTR1 PPP1CC CCNC-1 SMAD2;SMAD3 BMP2 TGIF2 E2F4-1 PARD6A MTMR4 ARRB2 SERPINE1 TFDP1 JUNB RNF111 TFDP2 PPP1CB SNW1 PPP1CA UBE2D3-1 NCOR2 TCF12 NCOR1 RHOA CDKN2B XPO1 UBA52 CBL AMHR2 CER1 EP300 FST FOXH1 RPS27A ZFYVE16 MEN1 PSEN2 LTBP4 LTBP2 UBB;UBC LTBP3 LTBP1 APH1A APH1B TGFB2 TGFB3 GDF2 SKIL SMAD9 INHBB INHBA SMAD5 DRAP1 BAMBI TGIF1-1 MYF6 TCF4 BMPR1B MYF5 BMPR1A ITGB1 ACVRL1 BMP10 BMPR2 ITGB5 CHRDL1 ITGB8 CDK8 PMEPA1 ITGAV PRKCZ ITGB6 FGF2 AMH PSENEN MYOG HELLS NOG UCHL5 KLF16 COL1A2 GREM2 MYOD1 STRAP PPP1R15A USP15 ACVR1B FSTL1 FSTL3 ACVR1C SP1 ACVR2B PARP1 ACVR2A INHA RXRA ATP1B4 CGN RARA F11R PSEN1 FKBP1A PARD3 SKI SMAD1 ITGA8 NCSTN SMAD4 SMURF2 SMURF1 SMAD6 SMAD7 RBL1 YBX1 MYC MYCN HDAC1 TNRC6C CCNK MOV10 TIMP2 TNRC6A-1 AGO4 USP9X CCNT1 AGO2 TIMP1 AGO3;AGO1 TNRC6B TGFB1 TGFBR3 GIPC1 ITGB3 MMP14 NEDD4L MMP16 ARRB1 UBE2D1 FURIN PPM1A CDK9 CCNT2-1 E2F5 TGFBR1-1 ARHGEF18 TGFBR2 MAPK1 MAPK3 STUB1 TRIM33 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins NUDT16 ADPRM NUDT15 NUDT5 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors HCAR1 HCAR2;HCAR3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation HSPD1 NPM1-2 TFAP2A MYBL2 NOP2 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily FBP1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 G6PC1 H2BC21 PWWP2B CHD5 IKZF1 IKZF2 SUMO1 IKZF3 H2AC20 PHF6 MBD3L1 H2AB2;H2AB3;H2AB1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 CBX3-1 ADNP2 ZNF687 TCF19 ADNP ZNF592 ZNF827 CBX1 NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 HDAC2 NR2C2 HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC1 GATAD2B GATAD2A H2AC4 PCK1 H2AC14 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9;CYP2C19 CYP1A1 CYP1B1 CYP1A2 CYP2U1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression TGFA MED1 GTF2A1 PTGES3-1 GTF2A2 YY1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C CREBBP ATF2 POLR2D POLR2G KDM4B KAT5 POLR2I H2AC20 GPAM H2AB2;H2AB3;H2AB1 POU2F1 NCOA1 NCOA2 PRMT1 NCOA3 JUN KAT2B H2AJ HSP90AA1 NR5A2 TLE3 FOS H2BC5 MYB H2BC1 KDM1A AXIN1 EP300 KPNA2 H2AC4 BCL2 DDX5 GATA3 CITED1 ESR1 SP1 H2BC21 HSP90AB1 TBP PGR CARM1 KCTD6 H2AZ2;H2AZ1 FOXA1 SMC3 FKBP4 MYC RAD21 JUND GREB1 STAG1 CXCL12 STAG2 HDAC1 SMC1A TFF1 KANK1 TNRC6C MOV10 CXXC5 TFF3-1 TNRC6A-1 AGO4 NRIP1 CCNT1 AGO2 USF2 USF1 CTSD AGO3;AGO1 ZNF217 FOSB TNRC6B EBAG9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 POLR2E CBFB POLR2F GTF2F1 POLR2H GTF2F2 RUNX1 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 CDK9 POLR2J;POLR2J2;POLR2J3 H2AC14 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants KRAS HRAS NRAS BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB-1 HADHA ACADL TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling SOS1 PIK3CA PTPN11 ANGPT4 ANGPT2 GRB7 ANGPT1 DOK2 TEK GRB14-1 PIK3R2 SHC1-1 PIK3CB HRAS PIK3R1 NRAS M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT8 CNOT9 DICER1 EIF4A3 ZFP36L2 AGO2 EIF4E EIF4B PAIP1 CNOT10 CNOT4 CNOT6 TNKS1BP1 PABPC1;PABPC3 CNOT7 CNOT6L CNOT11 CNOT1 CNOT2 EIF4G1 EIF4A2 BTG4 CNOT3 EIF4A1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex CDK1 CHEK2 CHEK1 SFN YWHAZ YWHAQ CCNB1 YWHAH YWHAG CCNA2-1 CCNA1 YWHAE YWHAB WEE1 CDC25C GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) RBX1 COPS4 COPS2 CDK7 ACTB-1 MNAT1 YY1 PIAS3 UBE2I POLD1 UBE2N PARP1 PIAS1 SUMO1 SUMO3 SUMO2 RFC5 RFC3 RFC4 RFC2 GPS1 RNF111 CETN2 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 ACTL6A LIG1 POLK POLE NFRKB RFC1 PARP2 ACTR5 USP45 DDB2 LIG3 RAD23A ERCC3 CHD1L PCNA MCRS1 ACTR8 UBA52 ERCC5;BIVM-ERCC5 RAD23B ERCC2 DDB1 GTF2H1 INO80C GTF2H3 INO80B GTF2H4 INO80E INO80D RPA1 XPA RPA2 COPS7B COPS7A XPC POLD3 TFPT POLD4 POLD2 RPA3 RPS27A XRCC1 INO80 POLE4 CUL4A UBB;UBC COPS3 COPS6 COPS5 ERCC4 POLE2 ERCC1 POLE3 RUVBL1 COPS8 CCNH CUL4B LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance SOAT1 AP2A2 SOAT2 NPC2 LDLRAP1 AP2S1 APOB CES3 LDLR PCSK9 CLTC LSR CLTA LIPA AP2A1 NCEH1 AP2B1 NPC1-1 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNA7;CHRFAM7A CHRNA2-1 CHRNA1 CHRNB4 CHRNA9 CHRNA3 CHRNB3 CHRNA5 CHRND CHRNA4 CHRNA6 CHRNG CHRNE SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation SOS1 IRS1 INSR SHC1-1 INS;INS-IGF2 GRB10 MAPK1 IRS2 MAPK3 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria GZMH;GZMB-1 BID CASP8 NMT1 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling PIAS1 SOCS3 PTPN6 PTPN11 PTPN1 SUMO1 IFNGR1 IFNGR2 JAK1 IFNG JAK2 SOCS1 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism ALDH3B2;ALDH3B1 PLPP3 SGPL1 PLPP2 ACER2 ACER1 PLPP1 ACER3 SGPP2 SGPP1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs RPS14 NCBP1 RPS17 RPS16 RPS19 MSI1 RPS18 HOXA2 ISL1 COL4A5 RPS11 GSPT2 RPL10A GSPT1 RPS10 LHX3 LHX2 RPS13 LHX4 RPS12 LHX9 USP33 ROBO1 UPF2 ETF1 ZSWIM8 SLIT1 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 LDB1 PSMB6 RPL10;RPL10L-1 PSMB7 NCBP2-1 PSMD6 RPS25 RPS27 PSMB4 PSMD7 RPS29 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A UBB;UBC RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RBX1 ROBO2 EIF4A3 CASC3 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 SLIT2 RPL31 RPL34 RPL8 RBM8A RPL9 RPL6 RPL7 RPS4X MAGOH;MAGOHB RPL35 RPL38 RPS3A UPF3B DAG1 RNPS1 RPL39 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 RPL23A ELOC-1 RPL11 RPL14 ELOB RPL13 RPL18 RPL17 RPL19 RPS15 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes LPL MED30 PDK4 ABL1 MED1 ACSL1 CDK8 MGLL MED4 CDK5 MED6 MED7 AGPAT2 PAXIP1 PEX11A CCNC-1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PAGR1 PPARGC1B CREBBP H2BC21 CIDEC WDR5 RXRA KDM6A GPAM H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 LPIN1 ASH2L MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 CEBPA NCOA1 NCOA2 ACSS3 NCOA6 ELOVL5 NCOA3 HDAC3 DGAT2 MED27 SIRT1 MED23 NCOR2 RBBP5 H2AJ NR5A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 AJUBA SCD H2BC1 THRSP FABP4 MED31-1 EP300 PHLDA1 H2AC4 ADIPOQ TBL1XR1 RB1 KMT2D KMT2C LIPE H2AC14 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EIF4A2 EIF4A1 EIF4E EIF2S2 EIF4B EIF2S3;EIF2S3B EIF2S1 RPS27L RPS15A RPS3 RPS2 FAU RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPS15 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing NTHL1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events PLA2G4A CAMK2G GNA14 GNA15 ADCY9 GNA11 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNAQ PRKAR2A PRKCG ITPR1 ITPR2 PRKCD NBEA PRKCA ITPR3 CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 PLCB3 PLCB4 PLCB1 AHCYL1 PLCB2 KPNA2 PRKX MAPK1 CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IP6K1 IP6K2 IPMK IPPK SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PIKFYVE MTM1 MTMR2 FIG4 INPP5F PI4K2B MTMR4 INPP4A PIK3C3 INPP4B MTMR10 MTMR12 PIK3C2A PI4K2A VAC14 PIK3R4 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin F2 F8 VWF GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling ERBB2 NRG1 NRG2 GRB7 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation ADAMTS2 ADAMTS3 P4HB COL4A5 COL16A1 COL12A1 COL1A1 COL1A2 ADAMTS14 COL23A1 COL17A1 COL13A1 COLGALT2 ITGB4 LOXL3 PLOD3 LOXL4 PLOD2 PLOD1 LOXL1 LOXL2 COL10A1 BMP1 COLGALT1 COL9A1 COL27A1 COL9A3 P3H2 COL9A2 COL18A1 P3H1 COL14A1 PCOLCE LAMC2 P3H3 COL2A1 CTSS LOX MMP20 COL4A2 COL4A1 COL4A4 COL6A2 PXDN COL4A3 COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 ITGA6 COL6A6 COL6A5 CTSB PPIB CTSV;CTSL PLEC MMP7 CD151 COL25A1 PCOLCE2 COL11A1 COL11A2 MMP3 SERPINH1 COL28A1 MMP9 CRTAP COL24A1 COL22A1 COL3A1 P4HA1 COL5A1 MMP13 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 COL15A1 LAMA3 COL19A1 COL26A1 LAMB3 TLL2 TLL1 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy ACY1;ABHD14A-ACY1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle UNC13B RAB3A SYT1 SYN3 VAMP2 STX1A CPLX1 SYN2 SYN1 SNAP25 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 APBA1 LIN7B CASK LIN7A LIN7C LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CALM3;CALM1 CAMK4 PRKACA-1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A BCL7C SMARCA2 DPF1 BCL7B SMARCA4 DPF2 DPF3 SMARCC1 ARID1A ARID1B ACTB-1 SMARCE1 SMARCD1 SMARCB1 SS18 BCL7A SS18L1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) EDEM2 EDEM3 AMFR RPS27A SYVN1 DERL2 EDEM1-1 RNF5 UBB;UBC RNF103 MAN1B1 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 SEL1L UBA52 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation MIXL1 SMAD2;SMAD3 LEF1 BMP4 CTNNB1 TCF7 FOXH1 SMAD4 POU5F1;POU5F1B SOX2 EOMES TBXT TRIM33 NANOG;NANOGP8 GSC TBPL2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome ARSB PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling FGF20 FGF23 INSR PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 CSNK2A1;CSNK2A3 BMI1 RING1 HDAC5 PSMD12 RNF2 PSMD11 PSMD14 HDAC7 PSMD13 REST CBX8 PSMA7 CBX6 PSMD8 PHC2 PHC1 PSMB6 PSMB7 CBX4 PSMD6 CBX2 PSMB4 PSMD7 PIP5K1A PIP5K1B PSMB5 PHC3 PSMB2 PIP5K1C PSMB3 PSMD2 EGF PSMD3 ERBB2 PSMB1 PSMD1 EGFR PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PSMA5 XIAP HGF SEM1 PSMA6 GAB1 PSMC5 PPP2R1A PSMA3 MET PSMC6 PSMA4 AREG PSMC3 PSMA1 PSMC4 PSMC1 FGF7 FGF22 FGF3 FGF10 KIT NTRK3 AKT1 UBA52 TSC2 KDM1A RPS27A UBB;UBC CASP9 PREX2 IER3 FLT3LG PDGFB CD19 EGR1 BAD CD28 SNAI1 SNAI2 STRN RCOR1 GAB2 PHLPP2 PHLPP1 IL33 CD86 IRAK1 KLB CD80 ATN1 SALL4 MAF1 INS;INS-IGF2 PDGFRB FGF19 FGFR4 AKT1S1 IL1RL1 TRAT1 RPS6KB2 FLT3 PIK3AP1 GSK3A TRIM27 USP13 TNKS TNKS2 RNF146 FRK PIP4K2A PDPK1 OTUD3 PIP4K2B PTEN PIP4K2C TRAF6 FYN MYD88 PTPN11 IRAK4 WWP2 FOXO4 FOXO3 EPGN TRIB3 STUB1 TGFA FOXO1-1 IRS2 ATF2 SGK1-1 LCK RRAGA RRAGC RRAGB SRC RRAGD EZH2 MAPKAP1 JUN CDKN1A CDKN1B RAC1 CHUK RPTOR NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF MBD3 SUZ12 RICTOR NTF3 GATAD2B GATAD2A PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG LAMTOR2 LAMTOR1 LAMTOR4 PPP2R5E LAMTOR3 LAMTOR5 VAV1 USP7 MDM2-2 SLC38A9 FGF2 GSK3B MECOM NEDD4 RHEB CHD4 CHD3 ESR1 THEM4 PRR5 EED MLST8 PPARG PIK3CD PIK3CG TP53 IRS1 PIK3R2 ESR2 PIK3CB NR4A1 PIK3R1 NR2E1 HDAC2 HDAC3 FRS2 HDAC1 PIK3CA PML MTOR TNRC6C MOV10 MTA1 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 TNRC6B CSNK2B RBBP7 MTA2 MTA3 MKRN1 NTRK2 BDNF MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis PDCD6IP GZMH;GZMB-1 CHMP3 PRKN CHMP6 CHMP7 OGT-1 SDCBP CASP5;CASP4 RIPK3 TP63 ITCH MLKL IRF1 IRF2 GSDME IL18 CASP1 IL1A IL1B TP53 ELANE XIAP FLOT2 CASP3 BAX TRADD FASLG TRAF2 PELI1 BIRC2 BIRC3 CASP8 HSP90AA1 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HMGB1-1 FADD CHMP4C CHMP4B CHMP4A UBA52 FLOT1 CYCS-1 CHMP2B RPS27A CHMP2A UBB;UBC CDC37 GSDMD BAK1 STUB1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events ARHGEF7 SOS1 GNA13 ARHGEF5 ARHGEF6 GNG10 NGEF GNG2 GNG5 GNG4 GNG8 PLXNB1 ABR RASGRF2 GNG13 GNB2 GNB1 ADRA1D PLEKHG2 ADRA1B GNB4 ADRA1A GNB3 TBXA2R GNA12 ARHGEF33 GNB5 ARHGEF37 ARHGEF38 SOS2 ROCK2 ARHGEF40 FGD1 FGD2 ROCK1 FGD3 FGD4 ARHGEF26 PLEKHG5 MCF2 BTK ECT2 RHOA ARHGEF39 KALRN NET1 TIAM1 GNGT1 ARHGEF10L AKAP13 MCF2L ARHGEF11 ARHGEF10 ARHGEF12 VAV3 ARHGEF15 ARHGEF17 TRIO ARHGEF16 ARHGEF19 ARHGEF18 ITSN1 RHOC VAV1 VAV2 RHOB TIAM2 PREX1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease ABCG5 DPM1 DPM2 DPM3 PDZD3 MARK3 DNAJC10 ELAVL2 UPK1A GBP2;GBP3;GBP1 FXR1-1 ABCC6 TPMT ABCC9 RPL10A DLL4 S1PR1 PPP1CC NEURL1 KERA SLC26A2 RAB5A RPL36AL-1 PRKG2 APOA1 TTR BCKDK MTRR RPL18A CYP2U1 SLC22A5 SLC35D1 TXN CD320 GBE1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP7B1 NT5E ACOT2;ACOT1 COMT RPL15-1 IDH1 OPLAH HK1 CYP2R1 DBT LUM CHSY1-1 LRAT RBP4 RBP1 RPL10;RPL10L-1 ABCB4 IQGAP1 SLC5A5 ABCA1 ARF1 RPLP0 RPLP2 RPL36-1 DLD VAMP2 RPL22L1 RPL37A-1 EPM2A KPNB1 CYP19A1 ACAT1 SRD5A3 B3GALT6 PIK3CD PIK3CG SLC25A15 RPL13A-1 SLC25A4 PPM1K MMAA MMAB RPL23A AHCYL1 ENTPD1 ENTPD5 PPP1R3C STX1A MMADHC PIK3R3 PIK3R6 PIK3R5 CTSA RPL27A WASL PPP1CA GGT1 MAT1A DPEP2 DPEP1 CYP11A1 GGT5 GCLC GCLM BCKDHA BCKDHB LMBRD1 PNP-1 RPIA CYP24A1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ENO1 RPL8 RPL9 RPL6 RPL7 FDXR CYP1B1 RPL35 RPL38 MMUT RPL39 CUBN RPL21 RPL23 RPL22 MED8 MED9 FDX1 RPL24 NHLRC1 RPL27 HPRT1 RPL26 RPL29 RPL28 PLCG2 CHST14 CDK19 RPL3L ADA RPLP1-2 IVD RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 FMO3 FMOD NAGLU GYG2 GYG1 ITPR1 ITPR2 ITPR3 CYP4F22 RPL7A SLC37A4 AMN UGT1A1;UGT1A6 KCNJ11 TXNRD1 RPL35A ASS1 IMPDH1 IMPDH2 MMACHC MTR-1 CYP27A1 ACY1;ABHD14A-ACY1 MAOA CYP27B1 SCAP ASL CBLIF GYS2 GYS1 AUH ALDOB NMRAL1 ABCD4 SLC2A1 SLC2A2 SGSH HIBCH ABCC2 ABCC8 DCXR B4GALT7 PTGES3-1 PRELP B3GAT3 POMC APP MEFV NFKB2 PYCARD P2RX7 PSTPIP1 CASP1 TXNIP SUGT1 SKP2 CARS1 RAP1B HGF GAB1 MET AREG NFE2L2 EEF1G EEF1A1 EEF2 FGF7 FGF22 FGF3 FGF10 WNT3A TSC2 KDM1A KIF5B KLC1 PHF21A RCOR1 HMG20B JAK2 RAD51B RAD51C DOCK2 HBD;HBB CDC42 GUCY2C NOS2 HGS ATP6V1H CORO1A RAB7A LMNB1 PAK2 IL10 MSN SOD2 HNRNPF HNRNPA2B1 SNRPA1 SLC1A1 SLC1A3 SLC3A1 SLC6A20 SLC6A19 SLC36A2 SLC6A14 SLC7A7 SLC7A9 DUSP6 DUSP7 CD163 PLK2 RHBDF2 MYH9 KAT5 DAXX HUS1 DNA2 RHNO1 MAPKAP1 PRDX2 PRDX1 ATRIP BARD1 RAD17 ATM ATR CDKN1A BRCA1 RPTOR RMI2 RMI1 TOP3A RAD51D WRN PMS2 RICTOR RPA1 RPA2 MLH1 RPA3 RAD1 MRE11 NBN CDC25C MSH2 BLM MDM2-2 NPM1-2 RAD9B RAD9A PRR5 EXO1 MLST8 TOPBP1 RFC5 RFC3 RFC4 RFC2 RBBP8 PML MTOR RAD50 TLR3 HDAC10 H2AC16;H2AC11 ARID4A BRMS1 H2BC18 KDM7A HDAC8 REST SLC35A2 SLC35A3 SLC33A1 SLC35C1 SLC25A5 SLC29A3 SLC27A4 SLC25A6 ROCK1 MUC13 RBMX KIT NTRK3 SLC9A6 SLC9A9 ADAMTS13 VWF CYFIP2 CYFIP1 NCKAP1 WASF1-1 WIPF1 WIPF2 WIPF3 BCR DYNC1LI1 DYNC1LI2 NCKAP1L HNRNPC NOX1 ARPC1B ARPC1A ABI2 TAOK1 ABI1 TPM4 TPM3 CLIP1 DVL1 DVL2 DVL3 ARPC4 ARPC5 ARPC2 ARPC3 NOXA1 MAP3K11 NCK1 ACTR2 LCK ROCK2 SRC CSK WASF2 WASF3 BAIAP2 BTK CFTR SPTBN1 STAM PTK2 C1QBP VAV3 RHOG VAV1 VAV2 WAS NOXO1 TRAK1 DYNC1I1 BCAP31 HDAC4 MYO9B UBE2I NR3C1 ESR1 SUMO1 ACTG1 ECHS1 PPIA CPS1 ARG1 TP53 OTC CYBA STAM2 CSNK2A2 NCKIPSD CSNK2B CPSF7 ACTR3-1 ZAP70 CSNK2A1;CSNK2A3 VIM HDAC11 IRF4 HDAC5 HDAC9 AGK HDAC6 HDAC7 STAT5A STAT5B EGF ERBB2 PLCG1 EGFR YWHAE GFPT1 AKAP9-1 PPP1CB PRKACA-1 PPP2R1A NEK2 MIB2 BTRC YWHAG SKP1 HSP90AA1 CDC73 LEO1 UBA52 DYNC1I2 CUL1 CCNB1 PRKAR2B RPS27A ELK1 UBB;UBC DYNC1H1 MAP2K4 MAPK9 MAPK8 MAP2K7 TUBB4A;TUBB;TUBB8B;TUBB8 CEP43 BCL2L11 BAD STAT3 BCL2L1 CAPNS1 CDH1 CAPNS2 BSG CAPN2 HEY1 HEY2 CAPN1 CAST ADAM10 HSPG2 BCAN ADAM17 PSEN1 ADAMTS16 NCSTN ADAMTS18 ADAMTS4 ADAMTS5 ADAMTS1 CTSG ADAMTS8 ADAMTS9 FOXO4 CTSV;CTSL FOXO3 MMP9 DCN ITGA4 FURIN ACAN KLKB1 RB1 CCNH H2AC14 TRIM28 TGFA MED1 YES1 MED4 MED6 MED7 FOXO1-1 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP IHH CCND3 CCND2 SMAD2;SMAD3 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L MED16 MED17 MED12 JUNB MED14 MED13 MED10 CD36 MED27 MED23 NCOR2 KAT2B H2AJ KAT2A NCOR1 MED24 TAL1 MED20 GPS2 SF3B1 MBD3 SUZ12 H2BC5 H2BC1 GTF2H1 GTF2H3 GTF2H4 GATAD2B ITGA2B GATAD2A MED31-1 ARID4B EP300 NRBP1 H2AC4 SAP30 TBL1XR1 KMT2D DNMT1 MED30 CDK6 ABL1 SUDS3 CDK8 CDK7 CDK5 ACTB-1 MNAT1 GSK3B RAD51 PSIP1 DPY30 CHD4 CHD3 SIN3A PARP1 H2BC21 GP1BA DNMT3B WDR5 CAMK4 TBP EED DNMT3A H2AZ2;H2AZ1 SMAD4 ESR2 NR4A1 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CAMK2B CAMK2D HDAC2 CAMK2A HDAC3 THBS1 HDAC1 HES1 CAMK2G MTA1 RBBP4 RBBP5 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L ITGB3 PROS1 H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 FGB FGA GP1BB ERCC2 FGG F2 F5 F8 F9 SERPING1 CLU F10 F12 F11 GP5 GP9 PROC EIF2AK2 PRKX POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B TLR1 POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 S100A9 C1GALT1C1 S100A8 ADAMTS2 LTF ADAMTS3 TLR2 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON MUC3A MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 CD4 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 PSMD12 GALNT3 MUC17 NOTCH1 PSMD11 C1GALT1 MUC5B PSMD14 MUC20 PSMD13 MUC21 IPO5 RBPJ GRSF1 DLL1 DNAJC3-1 PSMA7 PSMD8 LFNG PSMB6 BRCA2 PSMB7 RAD51AP1 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 XRCC2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 SLC17A8 PSMD1 IFIT1 IFIT3 IFIT2 ADRM1 VPS36 SNF8 VPS25 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 ATP1B2 MCCC2 BTD ATP1B1 PC PCCA HLCS MCCC1 PCCB ACACA RAF1 SLC5A7 YWHAB HSPA1A;HSPA1B ELAVL1 XPO1 AKT1 NUP214 YWHAZ XRN1 FXYD4 FXYD3 FXYD1 HSPA8 PABPC1;PABPC3 FXYD6 MAPK14 EIF4G1 RBX1 GNAS-1 ADCY9 ATP1A4 ATP1A3 PRKAR1B ATP1A2 PRKAR1A ATP1A1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 ATP1B3-1 FXYD2;FXYD6-FXYD2 PRKAR2A CSNK1A1 CLCN6 ITCH SLC35A1 B4GAT1 DAG1 FKBP1A LARGE1 CD3G CYSLTR1 CYSLTR2 POMGNT1 GNAT3 SYK SPRED3 SPRED2 FGR HCK ADORA2B SPRED1 GNAZ GNAI3 HRAS FCGR3A;FCGR3B FYN FCGR1A OPN1SW CUL3 NRAS NF1 MYD88 C3-1 NFKBIB CCNK NUP107 NUP188 CCNT1 IRAK4 GTF2B RCC1 TLR9 BANF1 KPNA1 SUPT16H NUP210 LIG1 LIG4 GTF2F1 HMGB1-1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 EPGN GTF2E2 NUP160 NUP85 ARRB1 TPR CLINT1 NUP88 AP1G1 SUPT4H1-1 AP1S2 XRCC6 NUP155 AP1S1 AP1S3 XRCC4 XRCC5 VTA1 NUP153 AP1B1 SUPT5H AP3B1 CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 RAB5C CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 ELOA AP1M2 NELFB ELOB AP1M1 NELFCD NELFA CCR5 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B GOLGB1 RANGAP1 NUP50 SFTPB POM121;POM121C SFTPC CHMP3 NUP54 CSF2RB CSF2RA CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 IRS2 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 WNT5A RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 FZD5 NCBP2-1 FZD4 TAF8 FZD7 TCEA1 FZD6 TAF7 FZD8 UBAP1 NUP35 ARRB2 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 IDUA HEXB NCAN HEXA BGN VCAN GLB1 HYAL1 IDS CSPG5 GUSB ARSB CHUK UBA7 TRIP11 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 HERC5 IFIH1 IKBKB TRIM25 ARIH1 IKBKG CLTC CLTA AP2A1 AP2B1 KEAP1 AP2A2 AP2S1 SH3GL2 AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E CDC37 ERBIN ATG7 PHB ITGB1 FGF2 JAG1 ALK LMO7 IRS1 PIK3R2 PIK3CB PIK3R1 CUL5 UBA6 MYC UBA5 JAK3 UBR4 FRS2 PIK3CA PTPN6 TNRC6C MOV10 AGO4 AGO2 AGO3;AGO1 TGFB1 CCND1 KRAS RUNX1 UBA3 UBA1 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 RNF213-2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 GOLGA2 SFN RIPK3 CDC25A ST3GAL1 CDC25B ST3GAL2 ST3GAL3 PRIM2 VPS16 PRIM1 MLKL SRPK2 POLA1 EDEM2 POLA2 PARP16 GSDME PARP14 SRPK1 PARP10 RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE JAK1 PDGFRA TOMM70 FGF6 PARP6 PARP4 PTBP1 PRMT1 RIPK2 SFTPD HNRNPH1 ANO8 ESRP1 HNRNPA1-1 ANO9 ANO6 HNRNPM TYK2 ANO4 CTNND1 PARP9 IL17RC ANO5 CBLL1 EPS15 ANO2 PARP8 IL17RA ANO3 MYO10 ANO1 MYO5A SIKE1 MYO1C SMN2;SMN1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 GPC4 RPS2 MGAT2 GPC6 STAT1 STAT2 SEC24D-1 MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 GSDMD RPS9 RPS7 CASP9 RPS8 RPS5 VPS33A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU IFNAR1 SNRPB ATRX DDX5 FUT8 TKFC IRAK1 IRAK2 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG CAV1 MAVS OSTC SQSTM1 STT3A UBE2N FLT3 TAB3 TAB2 STT3B TAB1 GSK3A ST6GALNAC2 TRIM27 HSP90AB1 PRKCSH TNKS MGAT4A-1 RPS4X TNKS2 YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 C3AR1 IRF3 IL18 DAD1 IL1A TRAF3 IL1B MBL2-1 P2RX4 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 GNE NOD2 GANAB EIF4A2 SNRPG-2 EIF4A1 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 MGAT4B VPS45 SEC24C EIF4E CALM3;CALM1 PABPN1-1 GNGT1 CCNE2 CCNE1 GNG10 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GALE SI LCT B4GALT1 MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L E2F1 E2F3 JUN SNW1 MAMLD1 SLC24A5 CDKN1B SFPQ-1 RAC1 NRG1 NRG2 EREG BTC NRG3 NRG4 EXOC1 ELMO1 ELMO2 CRK DOCK1 HBEGF GBF1 CBL NTF3 NPLOC4 CDK4 CDK2 UFD1 PSEN2 APH1A APH1B FASN U2AF1L5;U2AF1 EIF4A3 CDC40 PSENEN SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 DHX38 SRSF11 SRSF4-1 ALYREF RNPS1 ABCD1 CBX1 SLC2A9 FKBP4 KANK1 TRADD LY96 FASLG TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD TLR4 SHC1-1 LYN UBE2D3;UBE2D2 NFKBIA NTRK2 BDNF CDK5R1 GCKR GCK TGFBR1-1 TGFBR2 MAP2K2;MAP2K1 RAP1A MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 SLC34A2 SLC34A1 GZMH;GZMB-1 IFNGR1 IFNGR2 P4HB NTHL1 MED19 MED15 MED18 MED11 ATIC CHST6 PPIB MED26 MED29 MED22 MED25 CYP21A2 MED21 P4HA1 P4HA2 P4HA3 SYT1 CHST3 ABCB11 RPL12-1 SYVN1 DERL2 RNF5 OS9 RNF185 TPST2 FLT3LG PDGFB TPST1 CD19 CD28 STRN GAB2 CD86 KLB PGK1 CD80 PDGFRB FGF19 FGFR4 AKT1S1 G6PC1 TRAT1 RPS6KB2 PIK3AP1 G6PC3 CASP5;CASP4 SP1 OGN TBXAS1 FGFR1OP2 ZC3HAV1 SNAP25 RDH12 JAG2 KPNA4-1 PTEN FN1 PPFIBP1 HYOU1 SHH CPSF2-1 DUSP8 DUSP9 ATL2 NEURL1B CRBN NUDT21 PGM1 HHAT FNTA MSH6 MSH3 LY6E FUS NACA RLBP1 KIAA1549 BCAS2 C1S E2F2 HNRNPA0 HNRNPA3 GPKOW CDC5L PDCD1 KDR TRIM24 ALG8 ALG9 ALG6 ALG2 ALG3 ALG1 DHX9 MC2R BST2 GRB2 SUGP1 IL22 AGTRAP CNKSR2 CNKSR1 NAGS PEX19 AGGF1 PEBP1 IGF1R IL6R DHDDS DNAJB11 PPIE PPIH PPIG SYT2 CD8B;CD8B2 TENT4A GALM-2 MYO18A OMD SUN2 TALDO1 ETV6 WDCP SV2C SV2B SV2A CD9 HNRNPU HNRNPR SLC4A1 SLC4A4 TFG MAP1B CTBP2 CTBP1 BRIP1 WDR61 ICOS NEU1 BTF3 HNRNPL HNRNPK HNRNPD CDKN1C WDR48 WDR33 APBB1IP GAS6 ISY1;ISY1-RAB43 EPCAM MED13L IL10RA EXT1 PHF5A AUP1 IPO7 PAPOLA EXT2 TXNL4A SLC39A4 SNRPN SLCO2A1 RAB5B FAM114A2 MCL1 NCL-1 SLC26A4 SLC26A3 AVPR2 PLRG1 TIRAP DNAJC8 CEBPD CD33-1 FIP1L1 SEC11A SEC11C SNRNP40 DNAJA2 KHK PPIL3 PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 NEIL3 GAA NEIL1 TLN1 APRT CSTF3 CSTF2 CD79B AHCY CD79A HIP1 SLC22A12 SLC22A18 CHMP1A HNRNPH2 TLR6 TLR5 LMNA EMC4 SPCS3 GNAI1 SPCS2 CYP17A1 SPCS1 GNAI2 CWC25 PPIL1-1 CWC27 CWC22 ALG14 ALG12 ALG11 PRPF6 PRPF8 CPSF4 CPSF6 CPSF1 CPSF3 CWC15 FGFR3 FGFR2 FNTB;CHURC1-FNTB FGFR1 SLC40A1 CGAS HEPH BLNK RBM5 HGSNAT RFT1 HES5 ARAF C4BPA C4BPB CLDN1 MPRIP LOC110384692;C4A;C4B_2;C4B GBP6 SND1 EML4 ABCB6 DHH SLC5A2 GRPEL1 ABCA3 ABCA4 PMM2 ERLIN1 ERLIN2 CP NAPEPLD NOX4 PQBP1 VAMP1 TLR10 SRRT SLC16A1 HEYL CALR-1 PIM1 KPNA7 KPNA5 KPNA3 S100A1 SNRNP200 PORCN QKI ZC3HC1 GGCX FOXM1 CTNNBL1 KSR1 SIGMAR1 KSR2 PPM1B BIRC6 PRCC GALK1 LRP5 LRP6 SLC12A3 SLC12A1 MERTK KDELR1 PRF1 CYP26B1 GCC2 CCAR1 SLC12A6 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 SEC31A PAF1 RETREG1 DHX15 GALT DHX16 DERL3 SLC3A2 DERL1 MIB1 DPAGT1 SH3GL3 MPI SH3GL1 ZBP1 SLC5A1-1 WBP11 HNRNPUL1 VCL RTN3 DOLK DDX46 DDX42 LRRFIP1 RBM17 DYNLT1 GALNS BUD31 CYP11B1;CYP11B2 RBM22 BCL2A1 DCTN1 DDX23 CSTF2T RRBP1 GBP7;GBP4 ERLEC1 SMNDC1 U2SURP HBA2;HBA1 FAM131B ABCA12 CLP1 DKK1 DKK2 DKK4 BIN2 TYRO3 BRAP SLC6A5 OGG1 SLC6A2 SLC6A3 GNS MRC1 SLC2A10 MRAS SF3B4 SF3B5 SF3B2 SF3B3 HMOX1 SF3B6 BRD4 DDX3X-1 SF3A3 SF3A1 SF3A2 XAB2 RHAG CLEC5A RPL5-1 RNF43 TCN2 VTN BAG4 BAG2 PAH MPDU1 STRA6 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 DUSP16 DUSP10 CX3CR1 SLC24A1 SLC24A4 UNC93B1 CLEC4M;CD209-2 PUF60 SNRPB2 PTPN12 GOLGA4 AQR SLC11A2 NUS1 BCL11A NMI SH3KBP1 PRPF19 ZMYM2 MED28-1 PCF11 AVPR1B KREMEN1 KREMEN2 PAPSS2 AVPR1A PAPSS1 PACS1 RDH5 SLC17A5 MAPRE3 AVP SLC20A2 CUX1 SHOC2 AXL GSS HDLBP EFTUD2 PDIA3 ABCG8 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery RPS14 GEMIN4 GEMIN5 RPS17 GEMIN6 RPS16 SNRPF SNRPD2 RPS19 GEMIN7 SNRPD1 GEMIN8 RPS18 SNRPB SNRPD3 RPS11 SMN2;SMN1 RPS10 RPS13 RPS12 RPS27L RPS15A RPS3 RPS2 SNRPE-2 RPS4X RPS3A FAU RPS25 RPS27A RPS27 RPS29 GEMIN2 RPS20 RPS21 RPS24 RPS9 RPS23 RPS7 RPS8 RPS5 DDX20 RPS6 RPSA SNRPG-2 RPS15 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 CDIPT PITPNM2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids ACOT8 ACOT4 SLC27A2 EHHADH-1 DECR2 HSD17B4 ABCD1 ACAA1-1 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease SOS1 STAT1 PIK3CA KANK1 STAT3 GOLGA4 ETV6 KDR STRN PIK3R2 PIK3CB HRAS PIK3R1 FIP1L1 PDGFRA BIN2 WDR48 NRAS PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PPIA PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 FGF22 FGF3 FGF10 PIK3R1 FGF1 FGF6 FGF4 FGF9 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor ATP6V0B FGF20 SOS1 FLT3LG FGF23 INSR GRB10 ATP6V1B2 ATP6V0C ATP6V1B1 AKT2 GAB2 FGF2 KLB PDE3B IDE PTPRF INS;INS-IGF2 FGF19 ATP6V1G3 FGFR4 IRS2 FLT3 PIK3R4 THEM4 ATP6V0E2;ATP6V0E1 PDPK1 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF6 NRAS FRS2 GAB1 PIK3CA PTPN11 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 CTSD TLR9 FGF7 ATP6V1H FGF22 FGF3 SHC1-1 FGF10 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 ATP6V0A4 ATP6V1D PTPN1 ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 ATP6AP1 TRIB3 MAPK1 MAPK3 TCIRG1 FGF1 FGF4 FGF16 FGF9 FGF18 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis FUT2 FUT1 CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly CALM3;CALM1 SERPINB1 CASP5;CASP4 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis NR1H3 RXRA FABP6 NCOR2 RXRB NCOA1 NR1H2 NCOR1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs CPSF1 NCBP1 CPSF3 CSTF3 PAPOLA CSTF2 NCBP2-1 CSTF2T SYMPK CPSF2-1 CPSF7 PCF11 PABPN1-1 NUDT21 CLP1 FIP1L1 WDR33 CPSF4 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins CYP24A1 CYP2R1 CYP26B1 CYP27B1 CYP26A1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation PRKCA STXBP3 STX4 PRKCB PRKCG SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CSNK2A2 RBX1 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 CSNK2A1;CSNK2A3 CCND1 CSNK2B SPOP UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 CDK4 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 CD274 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CUL3 PSMC2-1 PSMA2-1 PSMA5 SEM1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins FGG ITGA2B TLN1 VWF BCAR1 SRC FN1 RAP1A ITGB3 CRK PTK2 FGB FGA RAP1B APBB1IP DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS SFTPC ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 AVPR2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 RAB11FIP2 ADCY5 GNG13 MYO5B PRKACB-1 MIP AQP8 AQP10 GNB2 AQP9 PRKAR2A AQP6 GNB1 RAB11A AQP11 AQP4 GNB4 AQP5 GNB3 AQP2 GNGT1 AQP3 LOC100509620;LOC112267859;AQP7 GNB5 AQP1 PRKAR2B AVP PRKACA-1 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A3 SLC12A1 SLC12A6 SLC12A2 SLC12A4 SLC12A5 SLC12A7 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD MC2R POMC ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus MIB2 DLL4 NUMB PSENEN NEURL1 MIB1 DTX1 DTX2 JAG1 UBA52 ARRB1 DTX4 ADAM10 NOTCH1 DNER DLK1 ADAM17 CNTN1 ITCH DLL1 JAG2 PSEN1 RPS27A NCSTN PSEN2 ARRB2 UBB;UBC NEURL1B APH1A APH1B MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS36 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 TUFM AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 HSPA1A;HSPA1B HSPB1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 HSPA8 PSMB1 PABPC1;PABPC3 PSMD1 ADRM1 EIF4G1 PSMC2-1 PSMA2-1 PSMA5 SEM1 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 RPA1 RPA2 RPA3 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC REV1 RFC1 MAD2L2 REV3L PCNA UBA52 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors FTH1 MASP1 APOB APOA1 CALR-1 COL1A1 COL1A2 COL3A1 COLEC12 APOE MSR1 COLEC11 FTL-1 SCARA5 HSP90B1 COL4A2 MARCO COL4A1 SCGB3A2 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System EGF FGF10 AREG TGFA PRL AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol GSK3A BAD CDKN1A MDM2-2 CDKN1B AKT2 AKT3 CHUK GSK3B CASP9 AKT1S1 MKRN1 AKT1 TSC2 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib CDC37 ERBB2 ERBIN HSP90AA1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection PSIP1 BANF1 PPIA SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 SPINT1 HPN MST1 MST1R SPINT2 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly UQCR10 UQCRC1 UQCRC2 TTC19 LYRM4 HSCB LYRM7 UQCRB BCS1L UQCRFS1 C12orf73 UQCC3 UQCC2 UQCC1 HSPA9 SMIM4 LETM1 UQCRQ UQCR11 FXN CYC1 SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer GAB1 SOS1 PIK3CA PTPN12 HSP90AA1 NRG1 NRG2 EREG BTC EGF CDC37 SHC1-1 ERBIN NRG3 ERBB2 NRG4 PLCG1 EGFR HRAS PIK3R1 HBEGF NRAS RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria GSDMD BAX DIABLO-1 BAK1 GSDME CYCS-1 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade HSPG2 GPC6 F2 F3 F5 F7 F8 VWF F9 SERPINC1 AGRN F10 SDC1 GPC1 SDC4 PROS1 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis CASP3 GZMH;GZMB-1 BAX CHMP3 CHMP6 CHMP7 HMGB1-1 CHMP4C CHMP4B CHMP4A CASP5;CASP4 TP63 IRF1 IRF2 GSDME CYCS-1 CHMP2B IL18 CASP1 IL1A IL1B CHMP2A TP53 ELANE GSDMD BAK1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0B ATP6V0E2;ATP6V0E1 ATP6V1H ASAH1 ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V0D1 ATP6V1C1 ATP6V1G1 ATP6V1A E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins PRKDC UBE2D3-1 TMEM129 HLTF RNF152 SHPRH CTR9 UBE2B PEX10 RTF1 PEX2 PEX12 CDC73 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PEX13 PEX14 LEO1 RNF40 RNF144A SELENOS PAF1 WAC-1 RNF181 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RAD18 DERL1 BCL10 H2BC15;H2BC3;H2BC11;H2BC12 UBE2N H2BC5 PCNA UBE2D3;UBE2D2 UBA52 H2BC1 UBE2D1 RRAGA VCP-1 RPS27A UBE2E1 UBB;UBC UBE2J2 WDR61 UBE2V2 RNF20 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion INMT EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 N6AMT1 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 APEH ETF1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 TRMT112 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 GGT7 CNDP2 GGT6 CHAC2 CHAC1 GGCT GCLC GCLM GSS GGT1 OPLAH ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria DCXR INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling STAT1 STAT5A STAT3 IL9 STAT5B IL9R IL2RG JAK1 JAK3 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation EPCAM UPK1A FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation FGF20 FGF1 FGF9 FGF18 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism SLC34A2 SFTPB SFTPC CSF2RB CSF2RA ABCA3 SFTPD MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression CSRP1 SNCB MTF1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome RB1 DDX5 ZCRB1 VHL ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility NRG1 NRG2 RHOA EREG BTC EGF NRG3 ERBB2 NRG4 EGFR MEMO1 DIAPH1 HBEGF SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer CBL GAB1 SOS1 PIK3CA HSP90AA1 EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 VAMP1 SV2C SV2B SV2A DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA TRA2B SNRPD2 SNRPD1 SNRPD3 SNRPE-2 PTBP1 PPP1CB HNRNPH1 HNRNPA1-1 HNRNPM PPP1CA RBMX UBA52 NUP214 RPS27A UBB;UBC HSPA8 ZCRB1 SNRPF SNRPB DDX5 HNRNPC TCERG1 GPATCH1 PNN METTL3 CXorf56-1 ZNF830 SF1 SLBP DHX8 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PRPF38A SMU1 PPP1R10 NKAP UBL5 CPSF2-1 PRPF40A GCFC2 PRPF18 SDE2 TUT1 FAM32A NUDT21 CACTIN SRSF10 SRSF12 PRPF31 PDCD7 RBMX2 FUS PAPOLG SNRPG-2 SNIP1 SNRNP35 IK BCAS2 PRPF4B LENG1 PRPF4 PRPF3 HNRNPA3 SNRNP27 GPKOW SNRNP25 CDC5L NUP107 SNRPC NUP188 SNRPA PPP1R8;STX12 ZMAT2 ZMAT5 CCDC12 YJU2 EIF4E LSM5 NUP210 LSM4 DHX9 LSM3 LSM2 GTF2F1 LSM8 GTF2F2 LSM7 NUP93 SUGP1 LSM6 PABPN1-1 RBM25 NSRP1-1 PPWD1 DDX41 NUP205 USP39 SART1 METTL14 AAAS SNRNP70 TFIP11 SYF2 NUP160 LUC7L3 NUP85 PPIE C9orf78 PPIH TPR WBP4 NUP88 PPIG ZRSR2-1 RNF113A RBM39 NUP155 PPIL2 WTAP MFAP1 ACIN1 NUP153 RBM42 BUD13 HNRNPF SNRNP48 HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 FAM50A HNRNPU HNRNPR SNRPA1 NUP62 HNRNPL XRN2 HNRNPK HNRNPD WDR33 NDC1 SEC13 ISY1;ISY1-RAB43 NCBP1 NUP133 PHF5A PAPOLA TXNL4A NUP50 POM121;POM121C SNRPN NUP54 PLRG1 DNAJC8 POLR2A FIP1L1 NUP42 POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 NUP43 SRRM2 POLR2G POLR2I CRNKL1 RAE1 RANBP2 CSTF3 CSTF2 NCBP2-1 HNRNPH2 NUP35 CWC25 RBBP6 PPIL1-1 CWC27 CWC22 NUP37 PRPF6 PRPF8 CPSF4 CPSF1 SNW1 CPSF3 CWC15 RBM5 SF3B1 PQBP1 SRRT MTREX SNRNP200 CTNNBL1 PRCC NXT1 CCAR1 U2AF1L5;U2AF1 EIF4A3 CASC3 GLE1 NXF2;NXF2B;NXF5-1 THOC1 PCBP1 THOC3 PCBP2 THOC2 SYMPK THOC5 CDC40 RBM10 THOC7 THOC6 SRRM1 DDX39A DHX15 DDX39B DHX16 SARNP ZC3H11A SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 WBP11 RBM8A POLDIP3 SRSF1 NXF1 U2AF2 FYTTD1-1 DDX46 DHX38 DDX42 SRSF11 MAGOH;MAGOHB RBM7 RBM17 SRSF4-1 CHTOP BUD31 ALYREF RBM22 UPF3B RNPS1 DDX23 CSTF2T SMNDC1 U2SURP CLP1 YBX1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 POLR2E CPSF7 SAP18 POLR2F POLR2H POLR2L CHERP PUF60 SNRPB2 AQR PRPF19 PCF11 EFTUD2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOQ PRKAB2 PRKAA2 ADIPOR1 ADIPOR2 STK11 PRKAG2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 MUC17 MUC5B MUC20 MUC21 MUC12 MUC15 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC6 MUC13 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking TBC1D25 DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 RIN2 GABARAP AKT2 TBC1D13 AKT3 TBC1D14 RAB5B TBC1D17 RAB6B CCZ1;CCZ1B TBC1D15 TBC1D16 TRAPPC3 TRAPPC1 MAP1LC3B2;MAP1LC3B-1 ANKRD27 DENND4B DENND4A TRAPPC4 TRAPPC5 DENND4C HPS1 RAB39A HPS4 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 MON1A MON1B DENND1C DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D RAB4A DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 RAB33A TRAPPC6A TBC1D2 RABEP1 TRAPPC6B RAB7B RAB3IP ARF6 RAB5A RAB1A RABGAP1 YWHAE RAB1B RAB21 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB6A RAB33B-1 RAB11B RGP1 RAB10 RAB13 RAB18 RAB3GAP2 RAB3GAP1 RAB8A CHM OPTN-1 SBF1 SBF2 RAB14 AKT1 RAB11A TSC2 TSC1 RAB3A RAB9A RAB9B RAB7A DENND5B RABGEF1 RINL TBC1D10C RAB5C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 TRAPPC2L ALS2 SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 TBC1D7;TBC1D7-LOC100130357 RAB35 TBC1D24 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation PTGES3-1 HDAC6 HSP90AB1 RPA1 RPA2 YWHAE HSBP1 HSF1 EEF1A1 HSP90AA1 RPA3 VCP-1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly LAMA3 DST COL17A1 ITGA6 LAMC2 LAMB3 ITGB4 PLEC CD151 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBA1A TUBA1C ARL2 TUBB1 TUBA8 TUBA3E;TUBA3C-1 TUBB2B;TUBB2A TBCD TBCC TBCB TBCA TUBA4A TUBB4B TBCE TUBB4A;TUBB;TUBB8B;TUBB8 TUBB3;TUBB6 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis PIWIL2 PIWIL1 HENMT1 HSP90AA1 ASZ1 POLR2E MAEL TDRKH-1 POLR2F MOV10L1 POLR2H MYBL1 TDRD9 TDRD6 PIWIL4 TDRD1 POLR2L TDRD12 FKBP6 POLR2A PLD6 POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J;POLR2J2;POLR2J3 DDX4 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity MARS1 AIMP1 MARK3 AIMP2 SNAI2 AKT3 EPRS1 GSK3B CDH1 RARS1 SOX9 UBE2I CREBBP QARS1 POMC LARS1 LEF1 SUMO1 YWHAH EEF1E1 YWHAE HDAC1 SIRT1 YWHAG TFEB CTNNB1 WNT3A YWHAB MC4R HINT1 EDNRB PAX3 SOX2 TNFSF11 FOXD3 XPO1 ZIC1 EDN1 KIT EDN3 TFE3 MITF IARS1 SOX10 POU3F2 MC3R TFEC YWHAZ ALX3 TBX3 CSF1 MC1R KARS1 MC5R ID1 EP300 RPS6KA1 MAPK1 DARS1 MAPK3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin CDC20 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 PTTG1;PTTG2 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors HCRTR2 HCRTR1 NPFFR2 NPFFR1 NPFF HCRT QRFPR QRFP APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins CASP3 DSP CTNNB1 BIRC2 CASP8 PLEC VIM CDH1 BCAP31 OCLN-1 PRKCQ LMNB1 DSG1 BMX PTK2 SATB1 PRKCD TJP2 DSG2 TJP1 ACIN1 CASP6 PKP1 SPTAN1 DSG3 APC ADD1 CLSPN DBNL GSN STK24 CASP7 FNTA STK26 GAS2 MAPT ROCK1 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c ALG6 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRNA3 CHRND CHRNA4 CHRNG CHRNE KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA DIS3 YWHAZ PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 MAPK14 MAPK11 KHSRP AKT1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC24A SEC24D-1 SEC24C CALR-1 HSPA5 B2M CANX SEC31A PIK3C3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E BECN1 ATG14 SEC23A ERAP2 SAR1B ERAP1 TAP2 TAP1 PDIA3 PIK3R4 TAPBP SEC24B SEC13 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation CDK1 ATM PPP2R1A MTOR MDM2-2 AKT2 AKT3 CCNA2-1 CCNA1 AKT1 MDM4 UBA52 SGK1-1 CHEK2 RICTOR PRR5 DAXX PDPK1 CDK2 PPP2CB;PPP2CA MLST8 PHF20 RPS27A PPP2R5C CCNG1 CDKN2A PPP2R1B MAPKAP1 UBB;UBC TP53 RNF34 USP7 RFFL USP2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer GSK3A RICTOR PRR5 MTOR BAD CDKN1A MDM2-2 CDKN1B PDPK1 AKT2 AKT3 MLST8 CHUK FOXO4 FOXO3 MAPKAP1 FOXO1-1 GSK3B NR4A1 CASP9 AKT1S1 RPS6KB2 AKT1 TSC2 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes SLC35D1 MAOA UGT1A1;UGT1A6 FMO3 CYP26B1 CYP27B1 TPMT GGT1 CYP24A1 MAT1A CYP21A2 CYP7B1 CYP19A1 CYP11A1 TBXAS1 FDXR CYP1B1 CYP4F22 AHCY GCLC CYP11B1;CYP11B2 GCLM OPLAH CYP27A1 CYP2R1 CYP17A1 CYP2U1 ACY1;ABHD14A-ACY1 GSS FDX1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA HADH ECHS1 ACADS ACSM3 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) UHRF1 STPG4 METTL23 DPPA3 H2AC20 KDM6A H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AICDA TET3 KDM5A H2AC4 KDM5B KDM6B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation CD274 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 AP2A2 WNT5A PRKCA AP2S1 FZD4 CLTB ARRB2 CLTC PRKCB CLTA DVL2 AP2A1 PRKCG AP2B1 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia PROC F5 PROS1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR1C POLR2H POLR1D POLR2L CRCP BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis BLM ACD SPO11 TINF2 SYCP1 SYNE2 TERF2 SYNE1 POT1 SUN1 TERF2IP TEX12 TERF1-1 SMC1B MSH4 MSH5 DMC1 SYCP3-2 PSMC3IP RAD51 SYCE2 SYCE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MND1 HSPA2 MLH3 REC8 STAG3 SYCP2-1 H2BC21 RAD51C H2AC20 C1orf112 H2AB2;H2AB3;H2AB1 BRCA2 H2AZ2;H2AZ1 FIGNL1 SMC3 RAD21 RBBP8 STAG1 STAG2 ATM SMC1A RAD50 ATR BRCA1 PRDM7;PRDM9 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LMNB1 FKBP6 TOP3A H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 RPA1 SUN2 RPA2 MLH1 CDK4 CDK2 RPA3 H2AC4 MRE11 NBN H2AC14 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway DAAM1 WNT11 WNT4 PRKCG PSMD12 WNT5B RYK-1 PSMD11 WNT5A PSMD14 ROR1 PSMD13 ROR2 PSMA7 WNT1 FZD1 PSMD8 FZD3 FZD2 PSMB6 FZD5 PSMB7 FZD4 PSMD6 FZD7 PSMB4 FZD6 PSMD7 PARD6A FZD8 PSMB5 SMURF2 CLTB PSMB2 SMURF1 ARRB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PRICKLE1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 SCRIB PSMC1 RAC1 PFN1 RHOA VANGL2 CLTC CLTA AP2A1 UBA52 AP2B1 AP2A2 PRKCA AP2S1 RAC3 RPS27A UBB;UBC DVL1 PRKCB DVL2 DVL3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 SOS1 CDC37 SHC1-1 ERBB2 ERBIN PTPN12 HRAS HSP90AA1 NRAS RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 FOXP3 TNFRSF18 IL2RA IL2 CR1L;CR1 IFNG CTLA4 NFATC2 CBFB SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 PIK3CA PTPN11 NOX4 STAT5A CDKN1A STAT5B GAB2 PIM1 BCL2L1 GRB2 HRAS PIK3R1 FLT3 NRAS SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 FKBP1A TGFB1 SMAD4 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB-1 HADHA ACADVL MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands HDAC1 BDNF SST DLL1 SIN3A CRH NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay NCBP1 WDR82 PABPN1-1 RBM27 ZCCHC7 RBM26 YTHDC1 DIS3 ZC3H4 ZC3H3 YTHDC2 TENT4A TENT4B EXOSC10 RBM7 ZC3H18 SRRT ZFC3H1 EXOSC7 C1D EXOSC6 DXO EXOSC5 MPHOSPH6 EXOSC4 NCBP2-1 EXOSC9 MTREX EXOSC8 EXOSC3 EXOSC2 EXOSC1 ZCCHC8 XRN2 PAPOLG MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation CUL1 BTRC SKP1 CHUK RPS27A FBXW11 NFKB1 UBB;UBC MAP2K2;MAP2K1 MAP3K8 IKBKB MAP2K4 IKBKG TNIP2 UBA52 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors HIPK1 KAT2B HIPK2 WWTR1 MME NPR1 NPR2 NPPC CORIN CES1 TBX5 GATA4 NKX2-5 NPPA ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway ADCY9 ADCY4 GNAT3 ADCY3 ADCY2 ADCY1 GNAI1 ADCY8 GNAI3 ADCY7 GNAI2 ADCY6 ADCY5 GNAL ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME ABCB1 PON1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PON3 ABCC2 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell CBL MET EPS15 SH3GL2 SH3KBP1 RPS27A HGS UBB;UBC SH3GL3 STAM SH3GL1 STAM2 UBA52 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD OPLAH RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle HGS RAB9B RHOBTB3 CCNE1 CUL3 LRRC41 PLIN3 RAB9A VHL SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination TAF1D TAF1B TAF1C TAF1A CDK7 POLR2E POLR2F POLR2H MNAT1 POLR2L CAVIN1 ERCC3 ERCC2 GTF2H1 GTF2H3 UBTF GTF2H4 TBP TTF1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 CCNH AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification MGST3 GGT5 MGST1 MGST2 GGT7 GGT6 GGT1 AKR7A2 AKR7A3 DPEP2 DPEP1 CYP2A13;CYP2A6;CYP2A7-1 ACY3 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ACY1;ABHD14A-ACY1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events CASR DGKZ SOS1 LTB4R2 DGKQ DGKK DGKI PIK3R3 DGKH ABHD6 NTS MCHR2 HRH1 GRK5 MGLL TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 APP CCK KISS1 FFAR3;GPR42 GRK2 EGFR GCGR PRKCE PRKCD PRKCA TRIO RPS6KA3 RPS6KA2 RPS6KA1 ADRA1D ADRA1B ADRA1A TBXA2R CYSLTR1 CYSLTR2 HRAS NRAS SAA2;SAA1 MMP3 GNGT1 PLCB3 PLCB4 PLCB1 PLCB2 GNA14 GNG10 AGT GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 CHRM3 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 MCHR1 GCG MAPK7 BTK KALRN EDNRB HBEGF EDN1 EDN3 NPFFR2 NPFFR1 NPFF HCRT QRFPR QRFP HCRTR2 HCRTR1 FFAR1 OXTR RGSL1 PIK3R2 GRPR EDNRA TRPC7 PROK2 PROK1 PIK3R1 UTS2R TRPC6 PRKCH TRPC3 TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 ARHGEF25 LPAR3 FPR2 LPAR4 PIK3CA NTSR1 NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR PRKCQ FFAR4 FFAR2 GAST GPR39 RASGRP2 EDN2 RASGRP1 ANXA1 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP F2R PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 F2RL3 DGKG AVPR1B DGKE CHRM1 DGKD AVPR1A GPR68 DGKB GPR65 DGKA MAPK1 AVP CHRM5 PMCH MAPK3 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI1 GLI3 GLI2 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs CALM3;CALM1 PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG1 CAMKK2 PRKAG3 PRKAG2 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS PLA2G4A MBOAT1 PLAAT3 OSBPL8 OSBPL5 LPCAT4 LPCAT3 PLA2G1B PLA2R1 PLA1A OSBPL10 PLA2G5 PLA2G2A-1 PLA2G10;LOC100652777 PLA2G2F PLA2G12A PLA2G4F PLA2G2D JMJD7-PLA2G4B;PLA2G4B PLA2G2E PLA2G4D PLA2G4E DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation LIG1 RFC1 POLD1 PCNA PRIM2 GINS1 RPA1 PRIM1 GINS2 RPA2 CDC45 MCM7 POLA1 MCM8 POLA2 POLD3 GINS3 GINS4 POLD4 MCM3 DNA2 POLD2 RPA3 MCM4 RFC5 MCM5 RFC3 MCM6 RFC4 MCM2 FEN1 RFC2 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 SFTPB SFTPC CSF2RB CSF2RA SFTPD INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GRP GNB3 FFAR1 PCSK1 CDX2 GPR119 ISL1 CTNNB1 GIP DPP4 TCF7L2 LEP GNAT3 SPCS3 GATA4 SPCS2 SPCS1 FFAR4 GNG13 SEC11A SEC11C PAX6 GNB1 GCG ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization SYK SOS1 PIK3CA PIK3R2 PIK3CB PIK3R1 PDPK1 FYN GAB2 LYN LAT2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDK6 CDK4 CDKN2A TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins TACR2 TACR3 TAC3 TACR1 TAC1 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance APOA1 HDLBP AMN CUBN LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions BOC GAS1 CDON DHH IHH SHH PTCH1 HHIP RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle ADD3 GJA1 UACA GNA13 TRA2B STOM PTK2B SPEN HSPE1 FMNL3 SLC4A7 FMNL1 FMNL2 VIM CCP110 DOCK7 LBR HSP90AA1 VAPB DOCK10 DOCK11 VCP-1 TIAM2 RACGAP1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CAPZB CAV1 ACBD5-1 HSP90AB1 DOCK2 CDC42 HGS RAB7A LMNB1 PAK2 CCT2 DBT SLC1A5 CCT7 CCT6A MTMR1 IQGAP1 ARHGAP35 RAC1 ARAP1 RHOA ELMO2 DOCK1 LAMTOR1 STEAP3 LETM1 ACTB-1 SRRM1 DDX39B TIAM1 RAPGEF1 FRS3 SOS1 PIK3R3 WASL SHMT2 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L PREX2 PREX1 WDR91 ANKFY1 CEP97 FNBP1 STARD8 NDUFS3 BCR WDR81 DAAM1 NGEF IQGAP2 IQGAP3 ABR MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 EMD NUDC RRAS2 GMIP CIT CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 FGD1 FGD2 FGD3 CUL3 LMAN1 FGD4 RASAL2 FGD5 CHN2 CHN1 STX5 YKT6 FARP2 FARP1 USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 ABI2 TAOK3 SHKBP1 ABI1 GOPC FILIP1 AAAS PKN2 PKN1 UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 PHIP RHOBTB1 RHOBTB2 STIP1 DDRGK1 STK38 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 COPS4 NSFL1C COPS2 NOXA1 PLXNB1 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 NCK2 NCK1 PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK DSG2 SOS2 ROCK2 SRC PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF2 WASF3 RNF20 PCDH7 CDC42BPB BAIAP2 CDC42BPA CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 SPATA13 CFTR GRB7 TMEM87A PTPN13 GARRE1 TWF1 KALRN SCFD1 SPTBN1 STAM CLTC NET1 ANLN FAF2 KIF14 SH3RF1 MTR-1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC3 SPTAN1 GIT1 VAV3 CCDC115 RALBP1-1 RHOG RHOH RHOF CDC37 RHOC RHOD ERBIN VAV1 VAV2 RHOB RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ITGB1 ARHGEF6 AMIGO2 WAS NOXO1 PAK1 PGRMC2 SAMM50 EMC3 PAK3 PAK5 PAK4 BCAP31 GIT2 CAVIN1 MTX1 MYO9B MYO9A MPP7 DLC1 TRIP10 JAG1 ESYT1 TJP2 RTKN PRAG1 BUB1B-PAK6;PAK6 ARHGDIG ARHGAP39 ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 ARHGDIA PIK3R2 ARHGDIB ARHGEF40 CYBB PIK3R1 CYBA ARHGAP45 ALDH3A2 STAM2 ARHGEF26 ARHGEF25 FRS2 ARHGEF28 ARHGAP19 PIK3CA ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 ARHGAP22 ARHGAP20 HMOX2 RHPN2 ECT2 CPSF7 ARHGEF39 ARHGAP29 MACO1 OCRL ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 CKB ALS2 PEAK1 PDE5A CCDC187 MOSPD2 ARHGAP11A-1 FAM169A PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation NGF RHOA PIK3CA IRS1 PIK3R2 PIK3CB PIK3R1 IRS2 NTRK1 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CSNK2A2 CTNNB1 CSNK2A1;CSNK2A3 CANX CSNK2B PCSK6 CDH1 OST4 JUP MOGS SEC11A RPN2 SEC11C OSTC STT3A ARHGAP32 RPN1 PRKCSH FURIN DDOST DAD1 PIP5K1C PCSK7 SPCS3 ANK3 SPCS2 SPCS1 POMT2 GANAB POMT1 TMEM258 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CD4 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function HDAC1 NFE2 TNRC6C MOV10 TNRC6A-1 AGO4 RBBP5 KAT2B AGO3;AGO1 H2AJ TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBFB RUNX1 PRKCQ DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 SIN3B SIN3A PRMT6 H2BC21 SETD1B H2BC1 SETD1A GP1BA ITGA2B WDR5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 PF4;PF4V1-1 ASH2L ZFPM1 H2AC4 NR4A3 GATA1 KMT2D KMT2A PRMT1 KMT2C KMT2B THBS1 H2AC14 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism SORD AKR1B1 ALDOB ALDH1A1 KHK TKFC GLYCTK SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2;SMAD3 SMAD4 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression TP53 PRDM1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation NGF RHOA ARHGDIA NGFR CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine NEIL3 H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPG H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 OGG1 H2BC1 H2AC14 H2BC21 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GRP GNB3 FFAR1 PCSK1 CDX2 GPR119 CTNNB1 DPP4 TCF7L2 LEP GNAT3 SPCS3 SPCS2 SPCS1 FFAR4 GNG13 SEC11A SEC11C PAX6 GNB1 GCG SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR ARHGEF7 SOS1 TGFA SH3GL3 SH3GL1 ADAM10 ADAM17 SRC CDC42 EGF CSK PLCG1 HRAS EGFR PIK3R1 PTPRK EPS15L1 EPN1 STAM2 SPRY2 ADAM12 NRAS LRIG1 FAM83D AAMP GAB1 PAG1 PIK3CA FAM83B FAM83A PTPN11 SPRY1 PTPN3 AREG EPS15 EREG HGS BTC SHC1-1 HBEGF STAM EPGN UBA52 PXN CBL PTPN12 SH3GL2 SH3KBP1 RPS27A UBB;UBC ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling EREG BTC EGF NRG3 ERBB2 NRG4 PTK6 EGFR HBEGF NRG1 NRG2 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation TPST2 TPST1 ASPH ARSD-1 ARSL ARSJ ARSK ARSH ARSI RIOX2 ARSG ETF1 RPL27A RPL8 U2AF2 RPS23 KDM8 OGFOD1 JMJD4 DHPS FN3KRP JMJD7 ARSB RCCD1 EIF5A2 JMJD6 DNAJC24 DPH1 EEF2 DPH2 DPH5 DPH6 DPH7 ZC3H15 FN3K RWDD1 ICMT EIF5A;EIF5AL1 PROS1 DOHH RIOX1 DRG1 DRG2 SUMF2 SUMF1 STS F2 F7 FURIN F8 F9 F10 PROC GGCX ARSA RPS6 GAS6 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes TLE4 HDAC1 TLE3 TLE2 CTBP2 TLE1 CTBP1 LEF1 TCF7L1 TCF7 TLE5 TCF7L2 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR NGF NGFR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation EIF5A;EIF5AL1 DHPS DOHH EIF5A2 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade C1S C3-1 CD19 CFB C4BPA C4BPB VTN LOC110384692;C4A;C4B_2;C4B PROS1 C1QB CPB2 CD81 C1R C5AR2 CFI F2 C5AR1 C8B C8A CPN2 C2 CPN1 CR1L;CR1 C5 SERPING1 CLU C8G C6 C7 C3AR1 C9 CD59 CD55 CR2 CFHR1;CFHR2 CFH-3 ELANE C1QC FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation FGF20 NCBP1 FGF23 FGFR2 FGF2 POLR2E FGF7 POLR2F POLR2H GTF2F1 FGF22 GTF2F2 FGF3 FGF10 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J;POLR2J2;POLR2J3 NCBP2-1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function CSNK2A1;CSNK2A3 MOGS H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A RPN2 SEC11C RPN1 PSMD12 PSMD11 PSMD14 PSMD13 SMARCA4 FOXA2 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 SRC EZH2 PSMB6 TGIF2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PCSK7 SPCS3 PSMD3 ANK3 SPCS2 PSMB1 SPCS1 PSMD1 BANP ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 SIRT1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 H2AJ TCF12 CANX PCSK6 TLE1 SUZ12 H2BC5 UBA52 H2BC1 KDM1A DNM2 MPHOSPH8 RPS27A H2AC4 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 MDM2-2 SNAI1 SNAI2 CTNNA1 CDH1 KLF4 OST4 JUP STRAP OSTC STT3A TWIST2 SP1 H2BC21 VCL PRKCSH EED DDOST H2AZ2;H2AZ1 WT1 ARID1A DAD1 GANAB MYC CTSS HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 ZNF217 TNRC6B CTSB CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 FURIN ZMYM2 CTBP2 CTBP1 MAPK1 POMT2 RB1 MAPK3 POMT1 H2AC14 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones HDAC1 BRMS1 MTA1 SUDS3 HDAC10 RBBP4 NCOR2 RCOR1 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 SAP18 RBBP7 MTA2 MTA3 HMG20B GPS2 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC18 CHD3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 HDAC8 H2BC21 H2BC1 KDM1A REST GATAD2B GATAD2A H2AC20 ARID4B H2AC16;H2AC11 H2AC4 ARID4A SAP30 TBL1XR1 PHF21A HDAC2 HDAC3 H2AC14 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling RAI1 ARNTL CLEC1B MEF2D MAFK HELZ2 SIRT1 NFE2L2 NRIP1 MED1 CRTC1 LY96 HMOX1 APOB APOA1 PGRMC2 NPAS2 NR1D1 NCOR1 TLR4 PPARGC1A TGS1 CREBBP ATF2 SLC46A1 RORA XPO1 RXRA CLOCK CARM1 CHD9 PPARA HBD;HBB EP300 BACH1 HBA2;HBA1 TBL1XR1 MEF2C NCOA1 NCOA2 NCOA6 CRTC2 SMARCD3 HDAC3 CRTC3 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism NUP133 INPP5B NUP50 POM121;POM121C INPP5A PLCD3 NUP54 PLCD4 INPP5D PLCD1 INPP5J IP6K1 IP6K3 IP6K2 IPMK NUP42 NUDT11;NUDT10-1 IPPK NUP43 RAE1 RANBP2 PLCE1 PTEN MINPP1 MTMR9 NUP35 SYNJ1 PLCG1 INPP1 MTMR7 NUP37 NUDT4;NUDT4B NUP107 NUP188 PLCG2 INPPL1 ISYNA1 NUP210 PPIP5K1 CALM3;CALM1 PPIP5K2 OCRL NUP93 PLD4 PLCH1 NUP205 PLCH2 AAAS NUP160 NUDT3 NUP85 NUP214 TPR IMPA1 NUP88 IMPA2 NUP155 MIOX ITPK1 NUP153 ITPKB ITPKC PLCB3 PLCB4 ITPKA PLCB1 INPP4A PLCB2 PLCZ1 INPP4B NUP62 NDC1 SEC13 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells EPCAM UPK1A SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants GAB1 SOS1 PIK3CA HSP90AA1 EGF CDC37 SHC1-1 ERBIN ERBB2 PLCG1 EGFR HRAS PIK3R1 NRAS POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere DSCC1 CHTF18 CTC1 STN1 TEN1 ACD TINF2 TERF2 POT1 TERF2IP TERF1-1 RFC1 POLD1 PCNA PRIM2 PRIM1 POLA1 POLA2 POLD3 POLD4 POLD2 RFC5 RFC3 RFC4 RFC2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation FGF20 FGF23 ANOS1-1 FGF2 FGF22 FGF3 TGFBR3 FGF10 GIPC1 FGF1 FGF6 FGF4 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling SOS1 PIK3CA TREM2 GRAP2 PLCG2 KLRC4-KLRK1;KLRK1 RAC1 KLRC4;KLRC3;KLRC2;KLRC1 BTK B2M TYROBP KLRD1 LCP2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E LCK VAV3 SYK PIK3R2 PIK3CB PLCG1 HRAS VAV2 PIK3R1 FYN NRAS FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription TXN BCL2L11 FOXG1 AKT2 DDIT3 AKT3 BBC3 STK11 ABCA6 MSTN FOXO1-1 INS;INS-IGF2 KLF4 BCL6 CAV1 PPARGC1A G6PC1 CCNG2 CREBBP CITED2 NR3C1 SIN3A POMC SREBF1 SFN SMAD2;SMAD3 NPY YWHAQ AGRP CAT TXNIP SMAD4 RETN PCBP4 NFYA-1 RBL2 NFYB NFYC HDAC2 GADD45A HDAC1 BTG1 CDKN1A SIRT1 CDKN1B YWHAG FASLG KAT2B FOXO4 FOXO3 ATXN3 YWHAB FBXO32 AKT1 SIRT3 TRIM63 YWHAZ GCK SOD2 IGFBP1 EP300 PINK1 PCK1 PLXNA4 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA6 CDK1 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 PSMA1 PSMC4 PSMC1 HSP90AA1 GTSE1 FKBPL UBA52 PSMD12 PSMD11 HSP90AB1 PSMD14 PSMD13 CCNB2 PSMA7 CCNB1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC TP53 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PLK1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex ISCU CHMP3 CHMP2B CHMP6 CHMP7 CHMP2A MAP1LC3B2;MAP1LC3B-1 PIK3C3 CHMP4C CHMP4B BECN1 UVRAG CHMP4A PIK3R4 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX CYP27A1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) TDG LIG1 PARG PNKP POLB POLE MBD4 SMUG1 RFC1 NEIL2 PARP2 APEX1 ADPRS POLD1 LIG3 PCNA PARP1 NEIL1 RPA1 RPA2 NTHL1 POLD3 POLD4 POLD2 RPA3 RFC5 XRCC1 RFC3 RFC4 POLE4 FEN1 RFC2 POLE2 POLE3 MPG OGG1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation FGF20 CPSF6 BCR FGF23 PIK3CA CEP43 STAT3 FGFR1 TRIM24 GAB2 FGF2 BAG4 ERLIN2 STAT1 MYO18A LRRFIP1 FGFR1OP2 STAT5A STAT5B ZMYM2 PIK3R1 CUX1 FGF1 FGF6 FGF4 FGF9 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer EREG BTC EGF AREG TGFA EGFR HBEGF EPGN BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis DICER1 ANG PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism STX1A LHB AGT P4HB ISL1 INS;INS-IGF2 KLF4 ACE2 SEC11A GNG13 SEC11C PCSK2 PAX6 RAB27A ERO1B BCHE CTSZ GNB1 KIF5C ANPEP POMC CPA3 GNB3 INHA SLC30A8 SLC30A5 FSHB ATP6AP2 FFAR1 MYRIP GZMH-1 ENPEP PCSK1 CPB1 PLA2G7 CDX2 GPR119 CRHR2 GIP CLTRN MME DPP4 ACE IGF1 LEP MBOAT4 INHBC GNAT3 INHBE CPE REN SPCS3 SPCS2 SPCS1 GCG CTSG EXOC8 EXOC7 CTSD CGA CTNNB1 MYO5A EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 FFAR4 EXOC1 CPB2 GRP VAMP2 KIF5B KIF5A TCF7L2 CMA1 ACHE CES1 GATA4 TSHB INHBB INHBA INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling STAT1 TYK2 EBI3 IL27 IL6ST STAT3 CRLF1 IL27RA JAK1 JAK2 CANX SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation TRIM28 NUP133 L3MBTL2 RANGAP1 NUP50 POM121;POM121C NUP54 BMI1 SATB2 RING1 NUP42 PPARGC1A MDC1 CREBBP SATB1 NUP43 RNF2 HDAC7 RAE1 RANBP2 DAXX CBX8 NFKB2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 IKBKE CETN2 NUP37 NCOA1 NCOA2 NCOR2 BRCA1 ING2 IKBKG SUZ12 PCNA PCGF2 WRN MITF NUP214 AURKA RPA1 HERC2 UBA2 SAE1 HIPK2 EP300 DNMT1 MRTFA BLM MDM2-2 NPM1-2 CDCA8 CBX5 DDX5 PIAS4 HDAC4 PIAS3 UBE2I HNRNPC THRB CHD3 VDR NR1H2 RORA NR3C1 ESR1 SIN3A PARP1 NR2C1 PIAS1 NR3C2 TRIM27 NR4A2 ZNF350;ZNF432 NR5A1 AR DNMT3B RXRA SUMO1 SUMO3 SUMO2 RARA PGR DNMT3A PPARG INCENP PPARA TP53 BIRC5 SMC5 PARK7 SMC6 SMC3 DDX17 AURKB NSMCE3 RAD21 NSMCE2 HDAC2 VHL NSMCE1 HIC1 STAG1 EID3 ZBED1 STAG2 HDAC1 TP53BP1 SMC1A PML SP3 TOP2A TOP2B MTA1 NUP107 ZNF131 NUP188 SENP5 NRIP1 FOXL2 SENP2 SAFB NSMCE4A TDG TOP1 SP100 NUP210 UHRF2 RNF168-1 CASP8AP2 NOP58 RWDD3 NUP93 MBD1 RAD52 NUP205 AAAS TFAP2C NUP160 NFKBIA NUP85 TFAP2E;TFAP2B TPR NUP88 NUP155 XRCC4 RELA NUP153 XPC CDKN2A CTBP1 EIF2AK2 SENP1 TOPORS NUP62 HNRNPK NDC1 SEC13 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR TLR7 UNC93B1 CTSK CNPY3 TLR3 LGMN TLR9 CTSS CTSB CTSV;CTSL HSP90B1 TLR8 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis FLOT2 PDCD6IP TRADD FASLG PRKN TRAF2 PELI1 BIRC2 BIRC3 CASP8 HSP90AA1 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD OGT-1 SDCBP UBA52 RIPK3 ITCH MLKL FLOT1 RPS27A UBB;UBC CDC37 STUB1 XIAP TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e DPM1 DPM2 DPM3 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling FRS2 CBL FGF20 PPP2R1A FGF23 PTPN11 ANOS1-1 PPP2CB;PPP2CA FGF2 RPS27A FGF22 UBB;UBC FGF3 FGF10 MAPK1 BRAF MAPK3 FGF1 FGF6 MKNK1 FGF4 SPRY2 FGF9 UBA52 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 FGF20 FRS2 GAB1 SOS1 PPP2R1A FGF23 PIK3CA PTPN11 FGF2 KLB FGF19 FGFR4 UBA52 CBL PPP2CB;PPP2CA RPS27A UBB;UBC PLCG1 MAPK1 HRAS PIK3R1 BRAF MAPK3 FGF1 FGF6 MKNK1 FRS3 FGF4 SPRY2 FGF16 NRAS FGF9 FGF18 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle RHOV WDR6 ARHGEF7 DST ARHGAP12 USP9X TXNL1 PAK1 VANGL1 MAP3K11 ZNF512B DEPDC1B PAK4 GIT2 DLG5 NCK2 SPTBN1 NCK1 MYO9A EPHA2 CLTC PAK2 SH3RF1 WASL BUB1B-PAK6;PAK6 SPTAN1 TPM4 GIT1 TPM3 PARD6B CDC42 PARD6A IQGAP1 PIK3R1 PEAK1 CCP110 CEP97 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle PSMC1 CANX MOGS DERL1 UBXN1 NGLY1 MLEC ENGASE UBA52 RAD23B PRKCSH EDEM2 CALR-1 EDEM3 VCP-1 RPS27A AMFR SYVN1 DERL2 EDEM1-1 RNF5 UBB;UBC RNF103 MAN1B1 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 SEL1L GANAB PDIA3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions MYL6 ITGB1 TREM2 LIMK2 LIMK1 PAK1 TYROBP CDK5 PLXNB1 PAK3 GSK3B MYH9 HSP90AB1 TLN1 ROCK2 PIP5K1C ERBB2 NRP1 FYN ROCK1 MET FARP2 ARHGAP35 MYH14 RAC1 MYH11 HSP90AA1 MYH10 RHOA MYL12B CFL1 DPYSL4 DPYSL5 DPYSL2 PAK2 DPYSL3 PLXNC1 SEMA6A SEMA6D CDK5R1 PLXND1 ITGA1 SEMA7A SEMA3A RND1 CRMP1 SEMA3E RRAS ARHGEF11 PLXNA2 PLXNA3 ARHGEF12 SEMA4A CD72 SEMA4D PTPRC FES PLXNB3 RHOC RHOB SEMA5A PLXNA4 PLXNA1 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 PIK3R1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME ABCB1 ALB CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD11B1 HSD11B2 SERPINA6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis MYF6 TCF4 MEF2D ABL1 MYF5 CTNNB1 MAP2K6 TCF12 CTNNA1 MYOG MYOD1 CDC42 NTN3 CDH4 CDON CDH2 BNIP2 CTNNA2 MEF2A NEO1 MAPK14 SPAG9 MEF2C MEF2B;BORCS8-MEF2B MAPK11 MAPK12 CDH15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation NUP133 NUP155 NUP107 SUMO1 NUP188 RANGAP1 POM121;POM121C RCC1 NUP54 NUP35 NUP93 KPNB1 NUP62 RAN NUP205 UBE2I NUP37 NDC1 NUP160 NUP43 AHCTF1 SEC13 NUP85 TNPO1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening CACNA1E CACNB2 CACNB3 CACNB1 CACNA2D2 CACNA1A CACNG2 CACNB4 CACNA2D1 CACNG4 CACNA2D3 CACNA1B DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling USP8 PTPN18 MATK AKT2 AKT3 HSP90AA1 NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF AKT1 UBA52 PTPN12 RPS27A UBB;UBC EGF CDC37 ERBB2 ERBIN EGFR RNF41 STUB1 CUL5 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 SMARCC1 SMARCC2 CSNK2A1;CSNK2A3 BMI1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RING1 CREBBP CCND3 CCND2 PSMD12 SETD1B SETD1A RNF2 PSMD11 PSMD14 SMARCA2 PSMD13 SMARCA4 CBX8 AUTS2 IL2 IL3 H2AC20 PSMA7 GPAM CBX6 PSMD8 PHC2 H2AB2;H2AB3;H2AB1 LDB1 PHC1 SRC PSMB6 CBX4 PSMB7 PSMD6 CBX2 ELF1 NFATC2 ELF2 PSMB4 PSMD7 ASH2L PSMB5 PHC3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PRMT1 PSMA2-1 PSMA5 SEM1 ACTL6A PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 TP73 PSMC3 RSPO3 PSMA1 PSMC4 PSMC1 KAT2B H2AJ TCF12 PAX5 TAL1 OCLN-1 H2BC5 PCGF5 MYB UBA52 H2BC1 RYBP SOCS3 CSF2 ITGA2B TJP1 AXIN1 HIPK2 EP300 PF4;PF4V1-1 RPS27A ZFPM1 H2AC4 UBB;UBC GATA2 GATA1 KMT2D KMT2A PRKCB KMT2C KMT2B SPI1 NFE2 CDK6 ABL1 CLDN5 GATA3 CDK7 MNAT1 DPY30 SIN3B CTLA4 ESR1 SIN3A H2BC21 GP1BA SERPINB13 ITCH WDR5 LMO1 LMO2 CR1L;CR1 LIFR KCTD6 H2AZ2;H2AZ1 ARID1A ARID1B NR4A3 SMARCD1 SMARCD2 SMARCD3 THBS1 HDAC1 PML CTSK PTPN11 FOXP3 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 BLK AGO2 RBBP5 AGO3;AGO1 TNRC6B CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B CBFB RUNX1 SOCS4 PRKCQ SMARCE1 H2BC15;H2BC3;H2BC11;H2BC12 PRMT6 PBRM1 YAF2 ACTL6B TNFRSF18 IFNG YAP1-1 IL2RA SMARCB1 CCNH ARID2 LGALS3 H2AC14 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex TICAM2 LY96 TICAM1 RPS27A IRAK2 TRAF6 CD14 UBB;UBC MAP3K7 TLR4 TAB3 TAB2 UBA52 TAB1 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization PML UBB;UBC NEDD4 PTEN USP7 XIAP RPS27A UBA52 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT9A SFRP1 SFRP2 WIF1 SOST KREMEN1 KREMEN2 WNT3A DKK1 DKK2 DKK4 WNT4 LRP5 LRP6 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 URM1 WDR4 THADA LAGE3 EPRS1 OSGEP TRMT112 THG1L ALKBH8 TRMT44 C9orf64 TRDMT1 PUS3 TRMT10A METTL1 NSUN2 TPRKB ADAT1 TRMT1 NSUN6 CDKAL1 PUS7 FTSJ1 TP53RK ADAT3 TRIT1 ADAT2 QTRT1 TRMT9B DUS2 QTRT2 CTU2 CTU1 TRMT6 TRMT13 TRMT11 TRMT61A TYW5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway FANCD2 ATR FANCI FANCC UBA52 RPA1 RPA2 MUS81 DCLRE1B EME1-1 DCLRE1A FAAP24 SLX4 LOC105377022;FANCB RPA3 EME2 USP1 RPS27A FAAP100 POLN CENPX UBB;UBC FANCM FANCL FANCA FANCE SLX1A;SLX1B ERCC4 FANCG ATRIP FANCF ERCC1 UBE2T FAN1 WDR48 CENPS-CORT;CORT;CENPS SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state RBX1 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 PSMA5 ORC1 ORC3 SEM1 PSMA6 ORC2 CDT1 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 ANAPC15 ANAPC16 CUL1 UBE2D1 ANAPC10 MCM7 ANAPC11 CDK2 MCM8 FZR1 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 RPS27A MCM6 MCM2 UBE2C UBE2E1 UBB;UBC UBE2S CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS ABCC2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCR4 CCL3L1;CCL3L3;CCL3;CCL18 CXCL12 CXCL9 CXCL8 CXCL13 CX3CL1 CCRL2 XCR1 CCR9 XCL1;XCL2 CXCL5;CXCL6 CCR8 CCR7 CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 CCL17 CCR10 CCL16 CCR1 CX3CR1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 PF4;PF4V1-1 CCR6 CCR2 CCR5 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling CASP10 FADD FASLG CASP8 FAS REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription SNAI1 ZEB2 PRDM8 HEYL ILF3 FOXF1 BHLHE22 SP1 HOXC8 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 HES1 SNW1 HNF1B MAMLD1 NEUROG3 RBPJ KAT2B KAT2A MAML2 EP300 MAML1 ONECUT1 MAML3 CREBBP SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases ADD3 GJA1 UACA GNA13 TRA2B STOM PTK2B BUB1 CLASP2 SPEN LIMK2 LIMK1 HSPE1 FMNL3 SLC4A7 FMNL1 PPP1CC FMNL2 VIM PIK3R4 SFN RPS27 YWHAE CCP110 PPP1CB MAPRE1-1 DOCK7 LBR PPP2R1A YWHAG HSP90AA1 PPP1R12A CKAP5 VAPB PAFAH1B1 DYNC1I2 KDM1A DOCK10 DOCK11 KIF5B KIF5A VCP-1 CLASP1 KLC1 DYNC1H1 TIAM2 NDE1 KLC4 PLK1 KLC3 KLC2 RACGAP1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CDH1 CAPZB CAV1 ACBD5-1 HSP90AB1 KIF2A YWHAQ YWHAH PDPK1 KIF2C KIF2B DOCK2 CDC42 PIK3C3 CENPE KLK3;KLK2 HGS CALM3;CALM1 RAB7A LMNB1 CFL1 PAK2 CCT2 DBT SLC1A5 H2AC14 CCT7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCT6A MYH9 MTMR1 H2AC20 H2AB2;H2AB3;H2AB1 IQGAP1 NCOA2 CDKN1B ARHGAP35 RAC1 H2AJ ARAP1 RHOA ELMO2 DOCK1 H2BC5 H2BC1 MEN1 LAMTOR1 H2AC4 STEAP3 LETM1 CDC25C ABL1 ACTB-1 SRRM1 DDX39B PIN1 H2BC21 H2AZ2;H2AZ1 BIRC5 AURKB H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 TIAM1 RAPGEF1 MAPK1 MAPK3 FRS3 S100A9 S100A8 SOS1 PIK3R3 KDM4C-1 BUB1B CDC20 BUB3 MAD2L1 WASL SHMT2 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F CTNNB1 LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 YWHAB PKP4 RBMX EPHA2 PICALM XPO1 PRKCD PRKCA YWHAZ ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MAPK14 MYLK PREX2 MAPK11 PREX1 WDR91 ANKFY1 CEP97 PRKCB FNBP1 STARD8 NDUFS3 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 WDR81 DAAM1 NGEF CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 GMIP CIT INCENP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 CENPA FGD1 CENPC FGD2 FGD3 CUL3 LMAN1 FGD4 RASAL2 FGD5 CHN2 CHN1 FLNA STX5 YKT6 CENPT FARP2 FARP1 NUP107 CENPU USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 CENPF CENPH ABI2 TAOK3 CENPI TAOK1 SHKBP1 CENPK ABI1 CENPL CENPM GOPC FILIP1 AAAS PKN2 CENPO PKN1 CENPP NUP160 NUP85 CENPQ UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 CLIP1 PHIP MAD1L1 LIN7B RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 DVL3 PLXNA1 SEC13 ABL2 SRGAP3 SRGAP2 NUP133 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 RANGAP1 NSFL1C ARPC2 ARPC3 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 NCK2 SPDL1 NCK1 PLEKHG3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 NUP43 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK RANBP2 DSG2 EVL PPP1R12B PFN2-1 SOS2 ROCK2 SRC SRF ROPN1;ROPN1B NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF2 WASF3 NUP37 RNF20 PPP1R14A PCDH7 CDC42BPB BAIAP2 CDC42BPA PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 BTK PFN1 CFTR GRB7 TMEM87A PTPN13 GARRE1 TWF1 KALRN MYL12B DSN1 SCFD1 SPTBN1 SCAI RCC2 STAM ZWINT CLTC PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 MTR-1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 PPP2CB;PPP2CA RAC3 SPTAN1 GIT1 PPP2R5B NDEL1 PPP2R5A VAV3 PPP2R5D CCDC115 PPP2R5C RALBP1-1 PPP2R1B RHOG RHOH RHOF PPP2R5E CDC37 RHOC RHOD ERBIN VAV1 VAV2 RHOB CTTN RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU TAX1BP3 ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ITGB1 ARHGEF6 AMIGO2 WAS NOXO1 PAK1 PGRMC2 SAMM50 EMC3 CTNNA1 PAK3 DYNC1I1 PAK5 PAK4 BCAP31 GIT2 CAVIN1 MTX1 MYO9B MYO9A MPP7 DLC1 TRIP10 JAG1 B9D2 ESYT1 SPC24 SPC25 TJP2 AR ERCC6L RTKN PRAG1 ZWILCH BUB1B-PAK6;PAK6 ARHGDIG ARHGAP39 PMF1;PMF1-BGLAP ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 ARHGDIA PIK3R2 ARHGDIB KNTC1 ARHGEF40 CYBB PIK3R1 CYBA ARHGAP45 SGO1 ALDH3A2 SGO2 STAM2 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 FRS2 ARHGEF28 ARHGAP19 PIK3CA ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 NCKIPSD ARHGAP22 ARHGAP20 MYH14 HMOX2 MYH11 RHPN2 ECT2 MYH10 CPSF7 ARHGEF39 ARHGAP29 MACO1 OCRL ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP DLG4 ACTR3-1 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 CKB ALS2 PEAK1 PDE5A ITGB3BP CCDC187 MOSPD2 ARHGAP11A-1 FAM169A CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine MAOA SLC6A3 COMT LRTOMT HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors LHCGR FSHR GPHA2 FSHB LHB TSHR GNRHR GPHB5 CGA TSHB GNRH1 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2A2 AP1G1 LCK CD8B;CD8B2 AP1S2 AP1S1 AP2S1 AP1S3 CD28 ARF1 AP1B1 B2M ATP6V1H PACS1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD4 AP1M2 AP1M1 AP2A1 AP2B1 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD AHCY LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux ABCA1 ABCG5 NR1H3 TNRC6C MOV10 APOC1 TNRC6A-1 APOC4 AGO4 AGO2 NCOR2 AGO3;AGO1 TNRC6B NCOR1 GPS2 KDM3A NR1H2 KDM4A APOC2 KDM1A RXRA APOD EP300 KDM1B CETP ARL4C TBL1XR1 EEPD1 ABCG1 RXRB APOE NCOA1 HDAC3 ABCG8 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown CDK1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C BANF1 LEMD3 NUP54 NUP210 NUP93 LMNB1 NUP205 NUP42 NEK9 NEK6 AAAS NEK7 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 PRKCA NUP155 CCNB2 EMD CCNB1 NUP153 LPIN1 LPIN2 NUP35 LPIN3 NUP62 VRK1 NUP37 PLK1 LEMD2 CTDNEP1 CNEP1R1 PRKCB NDC1 SEC13 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling CBL PPP2R1A UBB;UBC PTPN11 MAPK1 BRAF MAPK3 PPP2CB;PPP2CA MKNK1 SPRY2 RPS27A UBA52 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance PRKAB2 NOTCH1 HDAC6 DLL1 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PRKAG2 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG RAB8A CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D ATP5MC2 HAUS6 ATP5MC3 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A ATP5MC1 HAUS1 CEP63 MYB PAFAH1B1 TNPO1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B KIFAP3 HAUS7 CEP70 CHD9 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 MAPK14 ODF2 MEF2C CEP152 MAPK11 NDE1 PLK1 IFT172 TUBB4B CEP97 NEDD1 KIF3B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ CRTC2 ALMS1 CRTC3 KIF3C IFT52 CDK1 IFT57 DYNC2H1 TPTEP2-CSNK1E;CSNK1E IFT140 MEF2D CEP41 CEP43 RPGRIP1L HELZ2 WDR35 IFT88 SMO NRF1 KIF3A TTC21B WDR19 IFT122 MKS1 ALAS1 ATP5PF ATP5PD ATP5PB GRHL1 ATP5PO PRKAA2 ATP5MJ CALM3;CALM1 ATP5MG ATP5ME IDH2 GLUD1;GLUD2 SOD2 CCT3 CCT2 E2F5 TCP1 MAPK12 DMAC2L MED1 CCT8 HCFC1 CCT5 CCT4 PPARGC1A PPARGC1B CREBBP ATF2 ARF4-1 PRKAB1 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 E2F4-1 NPHP1 ESRRA NPHP3 MARK4 RAB11FIP3 ARL13B BBS2 BBS1 TFDP1 RAB3IP BBIP1 AHI1 CEP83 CEP89 C2CD3 NCOA1 GMNN PKD2 NCOA2 PKD1 DYNC2I2 TCTN3 DYNC2I1 TCTN2 NCOA6 TCTN1 TTC26 TRAF3IP1 BBS9 DYNLT2B CNGA2 KIF17 BBS7 HSPB11 CNGA4 DYNC2LI1 BBS5 CC2D2A IFT74 TP73 BBS4 DYNLT5 IQCB1 DYNLT2 IFT80 MKKS EXOC8 IFT20 PRKAG1 EXOC7 IFT22 ACSS2 KIF24 IFT43 IFT81 SSTR3 PRKAG3 BBS10 TTC30A;TTC30B BBS12 TRIP11 NCOR1 IFT27 RP2 DYNLRB2 TMEM216 EXOC4 DYNLRB1 EXOC3 IFT46 EXOC6 CLUAP1 EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 SIRT4 TMEM67 SIRT5 PDE6D RHO SEPTIN2 GBF1 SCLT1 RAB11A SIRT3 ATAT1 TTC8 CEP162 B9D1 CYCS-1 TBL1XR1 MICOS13 MICOS10 MCIDAS RFX2 RFX3 CCNO APOO APOOL MTERF1-1 TFB1M GABPA TFB2M PPRC1 MTX2 GRHL3 GRHL2 INPP5E SAMM50 DEUP1 TFAM-1 CHCHD3 CHCHD6 POLRMT POLG2 GMNC DNAJC11 TMEM11 TWNK MTX1 PERM1 FOXJ1 IMMT SSBP1 TGS1 B9D2 RXRA CAMK4 CARM1 PPARA SMARCD3 HDAC3 ATP5F1A ATP5F1B TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 CRTC1 AGO3;AGO1 TNRC6B ATP5F1C NR1D1 ATP5F1D HSPA9 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily MAFK NFE2L2 NQO1 CTNNB1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AXIN2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 CHD8 CREBBP CHD7 H2BC5 CHD6 CTCF NKD2 H2BC21 H2BC1 FAM124B IGF2 WDR5 H2AC20 H2AB2;H2AB3;H2AB1 CHD9 H2AZ2;H2AZ1 EP300 H2AC4 DKK2 H2AC14 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis ADSS1 PPAT ADSL ADSS2 ATIC GMPS DHODH CAD GART IMPDH1 IMPDH2 PAICS UMPS PFAS G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation GNB3 GNGT1 PDYN GNB5 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 OPRM1 GNAQ GNB2 GNB1 POMC GNB4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway CD80 PAK3 LCK VAV1 CD28 FYN PAK1 RAC1 CD86 PAK2 CDC42 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release CALR-1 CANX HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation HMMR HYAL1 HYAL3 HYAL4 GUSB HYAL2 LYVE1 CHP1 SLC17A5 STAB2 CEMIP HEXB SPAM1 HEXA SLC9A1 CD44 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage GSDMD CASP3 IL18 CASP5;CASP4 IL1B DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT2 DAG1 POMT1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules WAS GRAP2 PLCG2 PAK1 LCP2 PAK3 CD4 NCK1 PAK2 ITK LCK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 EVL CD3E CD3D HLA-DPA1 VASP FYB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ENAH CD3G HLA-DRA LAT CD101 PLCG1 ZAP70 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation S100A8 TLR2 ITGB5 ITGAV B2M SNAP23 TIRAP HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E STX4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 TLR6 SEC61A2 PSMB5 MRC2 PSMB2 SEC61A1 VAMP3 PSMB3 PSMD2 SEC61G PSMD3 SEC61B PSME1 PSMB1 PSMD1 CYBB SEC22B CYBA PSMB10 CD36 PSMB8 FCGR1A ADRM1 PSMB9 CD207 CTSS PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 MRC1 PSMC5 PSMA3 PSMC6 MYD88 PSMA4 PSMC3 PSMA1 LY96 PSMC4 PSMC1 CHUK BTK CTSV;CTSL CD14 HMGB1-1 TLR4 IKBKB IKBKG FGB FGA UBA52 NCF1 FGG NCF2 NCF4 CALR-1 VAMP8 PSME2 RPS27A S100A1 UBB;UBC TAP2 TLR1 LNPEP TAP1 PDIA3 TAPBP S100A9 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound KCNMB1 STX1A KCNMA1 CAPZB CACNB2 MYH9 CACNA2D2 SNAP25 EPB41L1 SLC17A8 CAPZA1 RIPOR2 CLIC5 CAPZA2 CIB2 PJVK EPS8 PCLO BSN TPRN PLS1 TMC1 ESPN-1 MYO7A SYP TMC2 MYO3B DNAJC5 MYO3A KCNQ4 FSCN2 MYO1C EZR PCDH15 USH1C ATP2B1 CABP2 TWF1 CABP1 LRRC52 ESPNL CDH23 OTOG CASK OTOF SPTBN1 CHRNA9 CHRNA10 XIRP2 KCNN2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX RAB3A LHFPL5 OTOGL VAMP2 MSN TMIE USH1G STRC SYN1 MYO15A SLC26A5 SPTAN1 CACNA1D GSN SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 MYF6 MYCN TCF4 MYF5 TNRC6C TIMP2 MOV10 TNRC6A-1 AGO4 TIMP1 AGO2 AGO3;AGO1 TNRC6B TGFB1 TCF12 FGF2 PSENEN MYOG HELLS KLF16 TGFBR3 GIPC1 MYOD1 MMP14 MMP16 SP1 ARRB1 ACVR2A INHA SMAD2;SMAD3 RXRA RARA PSEN1 EP300 NCSTN SMAD4 PSEN2 TGFBR1-1 ARRB2 TGFBR2 APH1A APH1B TGFB2 INHBA AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade GP1BA ANO6 F2 F5 F8 VWF F9 SERPINC1 SERPIND1 F10 F11 GP5 GP9 PROC SERPINE2 PROS1 SERPINA5 GP1BB NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) MEF2D EGR1 CDK5 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 CHD4 SH3GL3 ATF2 SGK1-1 REST SRF ID4 JUNB JUND TPH1 PPP2R1A MAPK7 FOSB TCF12 FOS CDK5R1 F3 DNM2 MAPKAPK2 NAB1 ID1 PPP2CB;PPP2CA NAB2 LYL1 ARC VGF EP300 PPP2R5D TRIB1 ATF1 RRAD ELK1 ASCL1 RPS6KA3 PPP2R1B EGR2 RPS6KA5 EGR3 RPS6KA2 EGR4 RPS6KA1 FOSL1 ID3 MEF2A CDK5R2 MAPK1 MAPK14 ID2-1 MEF2C MAPK3 MAPK11 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs PPP1CA ITGB1 ITGB5 ITGB8 PMEPA1 ITGAV ITGB6 TGFB1 PPP1CC UCHL5 TGFBR3 ITGB3 STRAP PPP1R15A USP15 NEDD4L XPO1 UBA52 CBL SMAD2;SMAD3 FURIN FKBP1A RPS27A ITGA8 SMAD4 SMURF2 LTBP4 TGFBR1-1 MTMR4 SMURF1 LTBP2 UBB;UBC TGFBR2 LTBP3 LTBP1 SMAD7 TGFB2 TGFB3 STUB1 PPP1CB BAMBI DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling USP8 UBB;UBC ERBB2 RNF41 AKT2 AKT3 NRG1 AKT1 NRG2 RPS27A UBA52 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM-2 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids PTGIS TBXAS1 CYP8B1 CYP4B1 CYP4F22 CYP4F3;CYP4F2;CYP4F12;CYP4F11 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling TRAF6 TLR7 IRF7 MYD88 UBE2V1 IRAK4 UBE2N TLR9 IRAK1 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation IRS1 INSR INS;INS-IGF2 GRB10 IRS2 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption RSC1A1 SLC2A5 SLC5A1-1 SLC2A2 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism PYGL PPP1R3C UGP2 GAA AGL-1 RPS27A PHKG1 PHKB PHKG2 EPM2A CALM3;CALM1 UBB;UBC GBE1 PGM1 GYG2 GYG1 PYGB GYS2 PHKA1 GYS1 PHKA2 NHLRC1 UBA52 PYGM MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST3GAL4 ST6GALNAC2 GALNT1 ST3GAL1 ST6GAL1 ST6GALNAC3 ST3GAL2 ST6GALNAC4 ST3GAL3 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins HOXC4 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 CTSA ACTR10 CD84 LOC102723996;ICOSLG CD4 HLA-DOA HLA-DOB SUPT6H MAF ZBTB17 VCAM1 IRF4 ITGB2 AFF4 TNFSF13B POLI POLH IRF8 DCTN6 DCTN5 STAT6 DCTN4 MLLT1 MLLT3 IWS1 NFKB2 RILP MCM3AP BATF IL4 ACTR1A MAFK CDC73 LEO1 MYB UBA52 DYNC1I2 DIS3 DCTN2 DCTN3 KIF5B KIF5A EXOSC7 KIFAP3 EXOSC6 KIF4B;KIF4A EXOSC5 EXOSC4 KIF20A EXOSC9 RPS27A EXOSC8 CR2 EXOSC3 EXOSC2 UBB;UBC EXOSC1 REV1 DYNC1H1 KLC1 MAD2L2 REV3L KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 DYNC1LI2 KIF18A STAT3 KIF11 KIF15 CAPZB KIF3A KIF23 KIF22 KIF2A OSBPL1A CR1L;CR1 KIF2C KIF2B CENPE MSH6 KIF26A CAPZA1 CTSS CAPZA2 E2F2 CTSK C3-1 CCNK CCNT1 CTSD CTSB SUPT16H CTSV;CTSL AICDA GTF2F1 GTF2F2 RAB7A ITGAL SUPT4H1-1 ITGA4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 E2F5 TAF4B ELL ELOC-1 WDR61 TAF7L ICOS ELOA NELFB MEF2B;BORCS8-MEF2B SMARCB1 ELOB NELFCD NELFA NELFE DPF1 DPF2 DPF3 SMARCC1 SMARCC2 CTDP1 PAXIP1 TAF9 POLR2A POLR2B MYH9 POLR2C CREBBP POLR2D SS18L1 POLR2G TAF9B POLR2I SMARCA2 SMARCA4 TAF15 TAF12 CD79B TAF13 CD79A TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 ASH2L TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SS18 NCOA6 ACTL6A PAX5 PCNA PMS2 MLH1 CTNNBL1 KMT2D KMT2C MSH2 ITGB1 CTR9 RTF1 ACTB-1 PAF1 DYNC1I1 BCL6 DPY30 PAGR1 BCL7A BCL7C BCL7B HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 EXOSC10 EXO1 KDM6A HLA-DPA1 TBP C1D HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 MPHOSPH6 DCTN1 ARID1A HLA-DRA ARID1B RFC5 RFC3 RFC4 RFC2 SMARCD1 CEBPA SMARCD2 JUND SMARCD3 E2F7 E2F8 RBBP5 FOSB POLR2E POLR2F POLR2H POLR2L SMARCE1 RFC1 RELA POLD3 POLD2 NFKB1 ICAM2 IFI30 BACH2 ICAM1 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy DYNC1LI1 TBK1 DYNC1LI2 ULK1 UBE2V1 IFT88 PRKN CSNK2A1;CSNK2A3 DYNC1I1 MAP1LC3B2;MAP1LC3B-1 PRKAB2 NBR1 PEX5 USP30 SQSTM1 UBE2N HDAC6 PRKAB1 CETN1 TOMM20 TOMM22 VDAC2-1 MAP1LC3A FUNDC1 ATG9A MFN1 ATG12-1 ARL13B MFN2 VDAC3 TOMM40 ATG5 MTERF3 TOMM7 PARK7 TOMM70 PRKAG2 ATM UBE2D3-1 CSNK2A2 PRKAA2 PRKAG1 HSF1 PRKAG3 HSP90AA1 OPTN-1 CFTR CSNK2B PLIN2 UBE2D3;UBE2D2 UBA52 EPAS1 DYNC1I2 PLIN3 VCP-1 RPS27A PCNT UBB;UBC PINK1 HSPA8 VDAC1 DYNC1H1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress NUP133 NUP50 POM121;POM121C NUP54 PTGES3-1 GSK3B AKT1S1 NUP42 HSPA2 CREBBP NUP43 HDAC6 HSP90AB1 RAE1 RANBP2 MLST8 NUP35 YWHAE HSPB8 HIKESHI CCAR2 NUP37 DNAJC2 DNAJC7 FKBP4 CAMK2B ST13;LOC107986532 CAMK2D CRYAB CAMK2A RPS19BP1 HSPA4L HSPA14 HSPA13 ATM DNAJB1 CAMK2G HSPH1 MTOR BAG5 ATR DNAJB6 NUP107 SIRT1 BAG3 NUP188 BAG1 HSBP1 HSPA1L HSF1 HSPA4 HSPA6 EEF1A1 HSPA12A HSP90AA1 HSPA12B RPTOR HSPA5 NUP210 NUP93 BAG4 BAG2 HSPA1A;HSPA1B NUP205 AAAS HSPA9 NUP160 NUP85 NUP214 TPR NUP88 NUP155 RPA1 MAPKAPK2 RPA2 NUP153 EP300 RPA3 VCP-1 HSPA8 NUP62 MAPK1 MAPK3 NDC1 SEC13 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death CD14 RIPK3 FADD TLR4 TICAM2 LY96 TICAM1 CASP8 RIPK1 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle HSP90AB1 DBN1 TRA2B TMOD3 MSI2 ACTN1 TXNL1 HSP90AA1 ACTG1 CCT2 CCT7 TWF1 SRRM1 MYO6 CDC37 PHIP DDX39B RHOBTB2 CCT6A HNRNPC RBMX CUL3 STK38 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 FKBP1A TGFB1 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD TRADD FASLG TRAF2 CASP8 TNFSF10 FAS RIPK1 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling APOC2 LPL APOA2 APOC3 APOE APOB APOA1 APOA4 APOA5 GPIHBP1 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein NUP133 NUP107 NUP188 NPM1-2 NUP50 POM121;POM121C RCC1 NUP54 NUP210 NUP93 KPNB1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing TRA2B SNRPD2 SNRPD1 SNRPD3 SNRPE-2 PTBP1 HNRNPH1 HNRNPA1-1 HNRNPM RBMX HSPA8 SNRPF SNRPB DDX5 HNRNPC TCERG1 GPATCH1 PNN CXorf56-1 ZNF830 SF1 DHX8 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PRPF38A SMU1 NKAP UBL5 PRPF40A GCFC2 PRPF18 SDE2 FAM32A CACTIN SRSF10 SRSF12 PRPF31 RBMX2 FUS SNRPG-2 SNIP1 IK BCAS2 PRPF4B LENG1 PRPF4 PRPF3 HNRNPA3 SNRNP27 GPKOW CDC5L SNRPC SNRPA PPP1R8;STX12 ZMAT2 CCDC12 YJU2 LSM5 LSM4 DHX9 LSM3 LSM2 GTF2F1 LSM8 GTF2F2 LSM7 SUGP1 LSM6 RBM25 NSRP1-1 PPWD1 DDX41 USP39 SART1 SNRNP70 TFIP11 SYF2 LUC7L3 PPIE C9orf78 PPIH WBP4 PPIG RNF113A RBM39 PPIL2 MFAP1 ACIN1 RBM42 BUD13 HNRNPF HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 FAM50A HNRNPU HNRNPR SNRPA1 HNRNPL HNRNPK HNRNPD ISY1;ISY1-RAB43 NCBP1 PHF5A TXNL4A SNRPN PLRG1 DNAJC8 POLR2A POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 SRRM2 POLR2G POLR2I CRNKL1 NCBP2-1 HNRNPH2 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 SNW1 CWC15 RBM5 SF3B1 PQBP1 SRRT MTREX SNRNP200 CTNNBL1 PRCC CCAR1 U2AF1L5;U2AF1 EIF4A3 CASC3 PCBP1 PCBP2 CDC40 RBM10 SRRM1 DHX15 DDX39B DHX16 SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 WBP11 RBM8A SRSF1 U2AF2 DDX46 DHX38 DDX42 SRSF11 MAGOH;MAGOHB RBM7 RBM17 SRSF4-1 BUD31 ALYREF RBM22 UPF3B RNPS1 DDX23 SMNDC1 U2SURP YBX1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 POLR2E SAP18 POLR2F POLR2H POLR2L CHERP PUF60 SNRPB2 AQR PRPF19 EFTUD2 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation ARHGEF7 SPRY1 PTPN3 AREG TGFA EPS15 EREG HGS BTC SH3GL3 STAM HBEGF SH3GL1 EPGN UBA52 CBL PTPN12 SH3GL2 SH3KBP1 RPS27A CDC42 UBB;UBC EGF EGFR PTPRK EPS15L1 EPN1 SPRY2 STAM2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DIAPH1 GMPR CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F2 KLKB1 SERPING1 F12 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling TBK1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 RIPK3 APP NFKB2 IKBKE RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 BIRC2 CHUK BIRC3 OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 TANK MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP TRAF2 TICAM1 CASP8 LRRC14 USP14 RIPK1 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 UBE2D3;UBE2D2 NFKBIA UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CFTR DERL3 DERL1 UBA52 PSMD12 ERLIN1 PSMD11 ERLIN2 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 VCP-1 PSMB4 RPS27A PSMD7 DERL2 ERLEC1 PSMB5 PSMB2 RNF5 PSMB3 UBB;UBC PSMD2 OS9 PSMD3 PSMB1 PSMD1 ADRM1 RNF185 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly ERCC2 CIAO3 ABCB7 CIAO1 NDOR1 CIAO2B CIAPIN1 NUBP1 NUBP2 BRIP1 MMS19 POLD1 RTEL1 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism PGK1 ENO1 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere CENPT CENPU RBBP4 NPM1-2 CENPN-2 KNL1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HJURP RSF1 CENPH MIS18BP1 OIP5 RBBP7 CENPW CENPI MIS18A CENPK CENPL CENPM H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 CENPO CENPP H2BC21 H2BC1 CENPQ SMARCA5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CENPX H2AC4 CENPA CENPC RUVBL1 ITGB3BP CENPS-CORT;CORT;CENPS H2AC14 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGF20 FGF23 FGFR3 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 PLCG2 PRKAR1B PRKAR1A YES1 ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A LYN IL10 ITPR1 ITPR2 ITPR3 PRKAR2B CD3G AHCYL1 SYK FGR HCK PLCG1 PRKX FCGR3A;FCGR3B FYN FCGR1A PRKACA-1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA PAPSS2 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases ACTB-1 HCFC1 UCHL5 YY1 OGT-1 USP15 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 H2AC20 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 SMAD7 PSMB1 PSMD1 ADRM1 BARD1 PSMC2-1 PSMA2-1 PSMA5 SEM1 ACTL6A PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 TGFB1 UCHL1 SENP8 NFRKB UCHL3 FOXK2 FOXK1 ACTR5 MBD5 MBD6 ASXL1 ASXL2 MCRS1 BAP1 ACTR8 UBA52 INO80C INO80B INO80E INO80D TFPT RPS27A INO80 H2AC16;H2AC11 TGFBR1-1 KDM1B H2AC4 TGFBR2 UBB;UBC RUVBL1 H2AC14 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants GAB1 SOS1 PIK3CA HSP90AA1 NRG1 NRG2 EREG BTC EGF CDC37 SHC1-1 ERBIN NRG3 ERBB2 NRG4 PLCG1 EGFR HRAS PIK3R1 HBEGF NRAS REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling IFNB1-4 SOCS3 USP18;USP41 TYK2 STAT2 PTPN6 PTPN11 PTPN1 JAK1 IFNAR1 SOCS1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO DCC ROBO1 ROBO2 NTN1 SLIT1 SLIT2 SRC NELL2 SLIT3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors PRKCA GRIA2 GRIA1 GRIP1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 PICK1 PRKCB AP2A1 PRKCG AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 HMMR YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 TPX2 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 AURKA HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding DTNBP1 TPD52L1 PUM1 AP4B1 IGF2R NECAP1 GOLGB1 YIPF6 ACBD3 SNAP23 STX4 CTSZ APP M6PR CLTB PIK3C2A GNS ARF1 HGS OCRL CPD PICALM CLTC GBF1 CLTA AP4E1 ARRB1 CLINT1 AP4M1 AP1G2 AP1G1 FTH1 DNASE2 AP1S2 DNM2 VAMP2 CLVS2 AP1S1 AP4S1 AP1S3 CLVS1 SH3D19 SH3GL2 TPD52 AP1B1 VAMP7 AP3B1 AP3S2;AP3S1 VAMP8 GAK DNAJC6 NAPA RAB5C CHMP2A TFRC TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 HSPA8 BLOC1S3 SNX9 AP1M2 SNX5 TXNDC5 AP1M1 TBC1D8B FTL-1 SNAPIN SORT1 HIP1R DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i ALG2 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis NR1H3 RXRA NRIP1 RXRB PCK1 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels KCNIP3 KCND1 KCND2 KCNIP1 KCND3 KCNIP2 KCNIP4 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors S100A8 BUB1 CLASP2 KDM4C-1 LIMK2 BUB1B LIMK1 CDC20 FMNL3 FMNL1 PPP1CC BUB3 FMNL2 MAD2L1 PIK3R4 SFN WASL RPS27 YWHAE ROCK1 PPP1CB MAPRE1-1 PPP2R1A YWHAG CTNNB1 KTN1 PPP1R12A YWHAB CKAP5 XPO1 PAFAH1B1 DYNC1I2 PRKCD KDM1A PRKCA YWHAZ KIF5B KIF5A CYFIP2 CYFIP1 NCKAP1 WASF1-1 WIPF1 CLASP1 WIPF2 WIPF3 DYNC1H1 KLC1 MAPK14 MYLK MAPK11 NDE1 KLC4 PLK1 KLC3 KLC2 PRKCB MRTFA DYNC1LI1 DYNC1LI2 MYL6 KIF18A DAAM1 CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 NCKAP1L CDH1 NOX3 NOX1 ARPC1B ARPC1A NUF2 KIF2A YWHAQ NUDC YWHAH PDPK1 KIF2C CIT KIF2B INCENP CDC42 PIK3C3 PKN3 CENPA CENPE CENPC FLNA CENPT NUP107 KLK3;KLK2 CENPU CENPF CENPH ABI2 CALM3;CALM1 CENPI TAOK1 CENPK ABI1 CENPL CENPM GOPC CFL1 PKN2 CENPO PKN1 PAK2 CENPP NUP160 NUP85 CENPQ NCF1 NCF2 NCF4 CLIP1 MAD1L1 LIN7B DVL1 DVL2 DVL3 H2AC14 SEC13 SRGAP2 NUP133 ARPC4 ARPC5 NDC80 RANGAP1 ARPC2 ARPC3 NOXA1 NF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SPDL1 NCK1 MYH9 ACTR2 NUP43 RANBP2 EVL PPP1R12B H2AC20 PFN2-1 H2AB2;H2AB3;H2AB1 ROCK2 SRF ROPN1;ROPN1B NSL1 IQGAP1 WASF2 WASF3 NUP37 NCOA2 PPP1R14A BAIAP2 PRC1 CDKN1B KNL1 ZW10 RAC1 H2AJ BTK PFN1 CFTR RHOA MYL12B DSN1 SCAI RCC2 ZWINT PTK2 H2BC5 AHCTF1 H2BC1 KIF14 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG MEN1 H2AC4 PPP2R5E RHOC RHOD RHOB CTTN TAX1BP3 CDC25C ABL1 RHOQ ITGB1 WAS NOXO1 PAK1 CTNNA1 ACTB-1 PAK3 DYNC1I1 PIN1 B9D2 H2BC21 SPC24 SPC25 AR ERCC6L RTKN ZWILCH PMF1;PMF1-BGLAP H2AZ2;H2AZ1 ACTG1 KNTC1 CYBB CYBA BIRC5 SGO1 SGO2 AURKB CENPS-CORT;CORT;CENPS NCKIPSD MYH14 MYH11 RHPN2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYH10 DIAPH1 H2BC15;H2BC3;H2BC11;H2BC12 DIAPH3 DLG4 ACTR3-1 MAPK1 MAPK3 ITGB3BP S100A9 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 CSNK2A1;CSNK2A3 SPOP LOC102723996;ICOSLG CD4 PRKAB2 RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAGT1 JAK1 ADRM1 PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 MIB2 NEK2 BTRC PSMC3 NFE2L2 PSMA1 BTLA PSMC4 TNFRSF14 YWHAG PSMC1 SKP1 CTNNB1 TCF7 TCF7L1 AKT1 UBA52 STAT1 CUL1 ATF3 PDCD1LG2 VCP-1 RPS27A MAP3K14 DERL2 TUSC3 UBB;UBC RNF5 OS9 MAP3K8 RNF185 TMEM258 CD28 STAT3 RBX1 GRAP2 CD86 CD80 OST4 OSTC STT3A CTLA4 STT3B PDPK1 IRF1 DDOST CD3G DAD1 CDC42 FYN CUL3 PTPN11 PDCD1 PRKAA2 PAK2 YAP1-1 TRIB3 H2AC14 WWTR1 YES1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP LCK PRKAB1 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L MAPKAP1 CSK SEL1L JUN TEAD1 PRKAG1 TEAD2 TEAD3 RAC1 H2AJ PRKAG3 TEAD4 FOS SUZ12 H2BC5 EPAS1 H2BC1 ERLIN1 ERLIN2 RICTOR CDK4 PPP2CB;PPP2CA PPP2R5B PPP2R5A EP300 PPP2R5D PPP2R5C PPP2R1B H2AC4 PPP2R5E VAV1 KMT2A KMT2C PAK1 PAK3 GSK3B DERL3 DERL1 DPY30 H2BC21 THEM4 PRR5 HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 EED MLST8 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 H2AZ2;H2AZ1 HLA-DRA PIK3CD ERLEC1 CD274 PIK3CG PIK3R2 B3GNT3 PIK3CB PIK3R1 HIF1A PRKAA1 MYC JUND MYCN PIK3CA MTOR PTPN6 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 BRD4 RBBP5 AGO3;AGO1 FOSB TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 LYN RELA TCF7L2 NFKB1 COPS5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) FFAR1 PCSK1 GPR119 ISL1 GIP DPP4 SPCS3 GATA4 SPCS2 SPCS1 SEC11A SEC11C PAX6 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 CD27 TNFSF8 TNFRSF13C LTBR RELB CD40LG TNF TNFSF13B PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 TRAF3 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC TNFRSF1A PSMC3 PSMA1 TNFRSF14 PSMC4 FASLG PSMC1 SKP1 TRAF2 BIRC2 CHUK BIRC3 FBXW11 UBA3 TNFSF11 UBA52 CUL1 TNFRSF18 RPS27A MAP3K14 EDA TNFRSF13B EDA2R TNFRSF8 UBB;UBC TNFRSF4 EDARADD TNFRSF12A TNFRSF1B EDAR LTA TNFRSF25 LTB TNFRSF11B TNFRSF11A TNFRSF17 TNFSF18 TNFSF14 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PAK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand S100A8 FGG TLR2 LBP LY96 APOB GSDME TLR6 S100A1 TLR7 CD14 HMGB1-1 TLR4 GSDMD CD36 TLR1 FGB FGA S100A9 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins TLR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB123 DEFB121 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB130B;DEFB130A DEFB105A;DEFB105B DEFB103A;DEFB103B DEFB4A;DEFB4B DEFB1 DEFB109B CCR6 CCR2 DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 DEFB114 DEFB110 TLR1 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions ITGA1 HSPA8 ITGB1 NRP1 CNTN6 CHL1 ITGA2 ITGA10 ANK1 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF NGF NTRK1 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes CREB3L4 CREB3L1 CREB3L2 MBTPS2 CREBRF CREB3 DCSTAMP MBTPS1 CREB3L3 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders SLC12A3 SLC12A1 NUP133 SLC34A2 SLC34A1 SLC12A6 SLC6A19 SLC39A4 NUP50 SLC36A2 POM121;POM121C SLCO2A1 SLC6A14 NUP54 SLC7A7 SLC26A4 SLC26A3 AVPR2 SLC7A9 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC3A2 BSG NUP42 SLC5A1-1 NUP43 SLC26A2 RAE1 RANBP2 SLC35A1 SLC35A2 SLC35A3 SLC33A1 SLC22A12 SLC35C1 SLC22A18 NUP35 SLC29A3 SLC27A4 SLC17A8 SLC5A5 SLC2A9 NUP37 SLC6A5 SLC6A2 SLC6A3 SLC2A10 NUP107 SLC24A5 NUP188 SLC40A1 HEPH NUP210 RHAG NUP93 SLC5A7 NUP205 AAAS SLC5A2 NUP160 SLC24A1 NUP85 NUP214 SLC24A4 TPR NUP88 SLC9A6 CP GCKR NUP155 GCK SLC9A9 SLC11A2 NUP153 SLC16A1 SLC2A1 SLC2A2 SLC4A1 SLC4A4 AVPR1B HK1 AVPR1A SLC1A1 NUP62 SLC1A3 SLC17A5 AVP SLC3A1 SLC20A2 SLC6A20 NDC1 SEC13 SLC22A5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling MET MYL6 RND1 RRAS ARHGEF11 ROCK2 LIMK2 ARHGAP35 LIMK1 MYH14 ARHGEF12 MYH11 RAC1 SEMA4D PLXNB1 MYH10 RHOA RHOC MYL12B ERBB2 RHOB ROCK1 MYH9 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis DGAT2 MOGAT2 MOGAT1 DGAT1 GPAM AGMO LPIN1 LPIN2 LPIN3 GK GPAT2 GK2 MOGAT3 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin MAOA ALDH2 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III TUBAL3 TUBA1A TUBA1C TUBB1 TUBA8 CHMP3 CHMP2B CHMP6 CHMP7 TUBA3E;TUBA3C-1 CHMP2A TUBB2B;TUBB2A IST1 CHMP4C VPS4A SPAST CHMP4B CHMP4A CC2D1B LEMD2 TUBA4A TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TUBB3;TUBB6 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex TBL1XR1 GPS2 NCOR2 NCOR1 HDAC3 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A2 MAN1C1 MAN1A1 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 RBX1 CDK8 DLL4 NUMB PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 DTX1 HDAC8 DTX2 JAG1 ADAM10 DTX4 HDAC9 DNER NOTCH1 HDAC6 DLK1 ADAM17 HDAC7 CNTN1 ITCH RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN ARRB2 NEURL1B MAML3 HIF1A MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 TLE4 TLE2 TLE1 UBA52 ARRB1 NBEA CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer HDAC1 IL10RA PTPN6 PRF1 TNRC6C GZMH;GZMB-1 MOV10 STAT3 RBX1 AGO4 NPM1-2 AGO2 SKP1 AGO3;AGO1 IRF4 CEBPB CUL1 STAT5A CCNB1 BCL2A1 JUNB ZC3HC1 FOXM1 MAPK1 ICOS ZAP70 RB1 MAPK3 RPS6 DNMT1 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism AGXT2 UPP1 TYMP NT5C UPB1 NT5E DPYD DPYS NT5C1A NT5M MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle ISCA2 CS ACO2 ISCA1 LYRM4 CSKMT SDHAF2 SDHAF3 IDH2 SDHC SDHAF1 SDHD ACAT1 SDHA SDHAF4 FXN SDHB SIRT3 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects HPRT1 APRT ADA PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation CCNK CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway ALDH1A2 RDH10 RDH14 RDH13 ALDH8A1 ADH4 CYP26B1 CYP26A1 ADH1C;ADH1B;ADH1A RDH11 RDH5 CRABP1 DHRS3 DHRS4 ALDH1A1 ALDH1A3 SDR16C5 DHRS9 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching ROBO1 ROBO2 NCK2 SLIT1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling SOS1 EREG BTC SHC1-1 NRG3 NRG4 HRAS HBEGF NRG1 NRAS NRG2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest E2F8 ARID3A CDKN1A CDKN1B CDK2 CCNA2-1 ZNF385A CCNA1 TP53 PCBP4 CCNE2 CCNE1 E2F1 E2F7 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 RAD51AP1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 PALB2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription MEF2D EGR1 FOSB TCF12 CDK5 CHD4 SH3GL3 FOS ATF2 SGK1-1 CDK5R1 F3 DNM2 REST NAB1 ID1 NAB2 LYL1 SRF ARC VGF EP300 ID4 TRIB1 ATF1 RRAD ASCL1 ELK1 EGR2 EGR3 EGR4 FOSL1 JUNB ID3 CDK5R2 ID2-1 JUND TPH1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 ARHGAP35 BCAR1 RAC1 RHOA ELMO1 HRAS ELMO2 RASA1 CRK DOCK1 NRAS PXN IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) BRCA2 SEM1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) MSH2 PMS2 RPA1 RPA2 MLH1 EXO1 POLD3 POLD4 RPA3 POLD2 LIG1 MSH6 POLD1 PCNA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle BCR ARHGEF5 STOM DAAM1 IQGAP3 ABR ACTC1;ACTG2 SNAP23 STARD13 JUP CAVIN1 MCAM CAV1 MYO9B MYO9A DLC1 ARHGAP1 TJP2 RTKN ARHGDIG ROCK2 ARHGAP39 CIT VAMP3 PKN3 PIK3R2 PIK3R1 ROCK1 ARHGAP5 PCDH7 ARHGAP21 ARHGEF25 FLOT2 ARHGEF28 OPHN1 ARHGAP35 MCF2 RHPN2 ECT2 VANGL1 DEPDC1B ARHGAP26 DIAPH1 ARHGAP32 PKN2 NET1 PKN1 ANLN DIAPH3 SOWAHC ARHGEF10L AKAP13 MCF2L STK10 FLOT1 SLK ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 TFRC ERBIN VAV2 RHOB PREX1 ARHGEF3 ARHGEF1 RACGAP1 STARD8 ARHGEF2 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL CBL PIK3CA PIK3R3 BLNK YES1 PIK3CD SYK PIK3R2 HCK PIK3CB VAV1 RAPGEF1 PIK3R1 FYN CRK CRKL LYN BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions CLEC4M;CD209-2 PPL BTNL9 BTN3A1;BTN3A3 BTN1A1 BTNL2 BTN2A2;BTN2A1 XDH DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation POLE4 PRIM2 POLE PRIM1 POLE2 POLA1 POLE3 POLA2 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID NFKB1 IKBKB RELA IKBKG NFKB2 CHUK NFKBIA REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death FLOT2 PDCD6IP TRADD FASLG PRKN TRAF2 PELI1 BIRC2 BIRC3 CASP8 HSP90AA1 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD OGT-1 SDCBP UBA52 RIPK3 ITCH MLKL FLOT1 RPS27A UBB;UBC CDC37 STUB1 XIAP INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling CA1 STAT3 P4HB GSTA3;GSTA5;GSTA1;GSTA2 AIP JAK2 IL23R IL23A PPIA CDC42 EBI3 IL27 IL6ST CRLF1 IL27RA MTAP JAK1 CAPZA1 RAP1B TYK2 ARF1 RPLP0 GSTO1 CANX PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A HSPA9 IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 STAT1 MSN MIF RALA-1 SOD2 TALDO1 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 TCP1 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAP2K2;MAP2K1 RAF1 MAPK1 BRAF MAPK3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA INSR PTPN11 GRB10 AKT2 GAB2 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 SHC1-1 INS;INS-IGF2 FGF10 FGF19 FGFR4 IRS2 FLT3 PIK3R4 THEM4 PDPK1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB MAPK1 HRAS PIK3R1 MAPK3 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism CYB5A SLC23A2 GSTO2 SLC23A1 CYB5R3 SLC2A1 GSTO1 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 BDNF PLCG1 NTRK2 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 PIK3R1 FGF1 FGF4 FGF16 FGF9 FGF18 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors HSPH1 APOB CALR-1 HSP90AA1 SCARF1 HYOU1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST3GAL4 ST6GALNAC2 GALNT1 ST3GAL1 ST6GAL1 ST6GALNAC3 ST3GAL2 ST6GALNAC4 ST3GAL3 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism ACP5 RFK SLC52A3 ENPP1 SLC52A1;SLC52A2 FLAD1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain PERP TP63 PPP1R13B TP73 NDRG1 CHM BCL2L14 TP53 RABGGTB RABGGTA TP53I3 BCL6 TP53BP2 BIRC5 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism ADAL NT5C2 PCK1 ADH1C;ADH1B;ADH1A DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling STAT1 TYK2 EBI3 IL6ST STAT3 IL27RA JAK1 STAT4 JAK2 IL12A CANX IL12RB2 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells UBB;UBC CTNND1 CDH1 CBLL1 SRC CTNNB1 RPS27A UBA52 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDK6 E2F2 CDKN1A CDKN1B CDK4 CDK2 CCND1 TFDP1 TFDP2 CCNE2 CCNE1 RB1 CDKN1C CCND3 E2F1 CCND2 E2F3 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis SLC35D2 FMOD CHST6 LUM B4GALT6 B4GALT4 B4GALT5 PRELP KERA CHST1 OGN ST3GAL4 CHST2 ST3GAL1 ST3GAL2 ST3GAL3 CHST3 OMD ACAN B4GAT1 B4GALT2 B4GALT3 B4GALT1 B3GNT7 B3GNT4 B3GNT3 B3GNT2 ST3GAL6 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors DIS3L2 PABPN1-1 PABPC1;PABPC3 EIF4A3 EIF4G1 EIF4A2 EIF4E EIF4A1 EIF4B TUT7 PAIP1 TUT4 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH-4 PECR SLC25A17 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle DBN1 TRA2B COPS4 SPEN TXNL1 ROCK2 COPS2 CCT2 CPSF7 CCT7 VIM SRRM1 MYO6 GPS1 RBBP6 RHOBTB1 PDE5A HNRNPC RBMX RNF20 ROCK1 CUL3 STK38 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin RBX1 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 PSMA5 ORC1 ORC3 SEM1 PSMA6 ORC2 CDT1 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CUL1 MCM7 CDK2 MCM8 MCM3 MCM4 MCM5 RPS27A MCM6 MCM2 UBB;UBC RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol RPS14 NOP56 SNU13 DDX49 NOP2 DDX47 WDR3 FCF1 NAT10 THUMPD1 WDR46 WDR43 RRP9 FBL LOC102724159;PWP2 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 DIMT1 IMP3 WDR75 IMP4 DDX52 UTP18 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 TRMT112 PDCD11 BMS1 DHX37 RRP36 UTP20 DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 NOL11 NOP10 RPS2 RPS9 RPS7 RPS6 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB NBEA ADCY9 PRKAR2B PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 PRKX ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKACA-1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 MDM2-2 PSMC3 PSMA1 PSMC4 PSMC1 TGFB1 CBFB RUNX3 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 EP300 PSMB4 RPS27A PSMD7 CDKN2A PSMB5 SMURF2 PSMB2 SMURF1 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli CSNK2A1;CSNK2A3 HSPE1 RPL10A BMI1 ETS1 RING1 PGD RNF2 HDAC6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 EGF NFYA-1 RPL36AL-1 YWHAE GFPT1 PRKACA-1 ACTR1A PPP2R1A BTRC APOA1 SKP1 HSP90AA1 AQP8 AJUBA UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 PRKAR2B RPL18A RPS27A RPS6KA3 UBB;UBC RPS6KA2 RPS6KA1 DYNC1H1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 MAPK8 MAP2K7 HSP90B1 MAPK10 TXN HELZ2 STAT3 BCL2 DDIT3 BCL2L1 CAPNS1 CAPNS2 CSRP1 CAPN2 SNCB HSPG2 NFYB NFYC RPL15-1 FOXO3 IDH1 MMP14 GSTA3;GSTA1 ITGA5 SPP1 YAP1-1 RB1 EHMT2 EHMT1 H2AC14 MED1 NOS3 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CREBBP H2AC20 H2AB2;H2AB3;H2AB1 EZH2 RPL10;RPL10L-1 CAT NCOA1 NCOA2 NCOA6 SIRT1 UBE2D3-1 HSBP1 RPLP0 HSF1 NCOR2 H2AJ NCOR1 RPLP2 RPL36-1 CDKN2B SUZ12 H2BC5 SIRT3 H2BC1 ID1 CYCS-1 EXTL2 IGFBP1 EP300 ADD1 H2AC4 EXTL3 TBL1XR1 FABP1 CDK6 ABL1 RPL22L1 RPL37A-1 GSK3B HSPA2 CITED2 SIN3A H2BC21 EED H2AZ2;H2AZ1 COX4I1 COX4I2 PIK3CD ME1 ARNT CAMK2B CAMK2D CAMK2A RPL13A-1 SMARCD3 HDAC3 HSPD1 CXXC1 CAMK2G RBBP4 CRTC1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 ITGB3 H2BC15;H2BC3;H2BC11;H2BC12 NDUFA4 RPL23A ATP7A DEFA6;DEFA4;DEFA5 ATOX1 RPL27A PSMD12 NOTCH1 PSMD11 PSMD14 P2RY2 PSMD13 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 PSMC3 ATP6V1E2 PSMA1 ATP6V1G1 PSMC4 ATP6V1G2 PSMC1 CTNNB1 G6PD ATP6V0D1 ATP6V0D2 HSPA1A;HSPA1B ATP6V1A XPO1 KHSRP AKT1 NUP214 DIS3 PRKCD ATP6V1D MAPKAPK2 ATP6V1C1 PARN ATP6V1F EXOSC7 GCLC ATP6V1C2 EXOSC6 GCLM EXOSC5 CHD9 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 HSPA8 MAPK14 MAPK11 TCIRG1 CRTC2 CRTC3 RAI1 BLVRB ATP6V0B CLEC1B MEF2D ATP6V1B2 BLVRA ATP6V0C RBX1 ATP6V1B1 GNAS-1 ADCY9 PRKAR1B PRKAR1A MBTPS1 ADCY4 RPL26L1 ADCY3 MBTPS2 ADCY2 RPL4 ADCY1 ADCY8 ATP6V1G3 RPL30 ADCY7 RPL3 ADCY6 RPL32 ADCY5 PRKACB-1 RPL31 RPL34 PRKAR2A RPL8 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 RPL35 RPL38 RPL39 RPL21 RPL23 RPL22 FYN CUL3 RPL24 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 NUP210 RPL3L NUP93 NUP205 RPLP1-2 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 ELOC-1 NUP62 RPL11 RPL14 ELOB RPL13 RPL18 RPL17 CACNB1 RPL19 CACNA2D1 NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 NUP42 CACNB2 CACNB3 NUP43 RAE1 RANBP2 ASNS NUP35 ALB NUP37 RPL7A GPX1 CXCL8 CHUK HSPA5 CCL13;CCL2 EIF2AK3 TXNRD1 RPL35A IKBKB IKBKG ATF6 FKBP5 SLC46A1 KEAP1 CHAC1 AMER1 TRIM21 PPP2CB;PPP2CA PPP2R5B PPP2R1B STOML2 PHB2 YME1L1 ITGB1 CHD6 PIK3R2 PIK3CB HIF1A CUL7 MYC COX7A2L-1 CUL2 ARNTL PIK3CA TNRC6C MOV10 TNRC6A-1 AGO4 NQO1 AGO3;AGO1 TNRC6B ABCG2 COX7A2 HSPA9 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 ACADVL CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ABCC3 ABCC1 RPS15 RPS14 GJA1 RPS17 RPS16 RPS19 RPS18 AKT2 AKT3 RPS11 RPS10 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 CAPZA3 ACTR10 ZBTB17 DCTN6 DCTN5 DCTN4 PANX1 P2RX7 RPS25 RPS27 TXNIP RPS29 RPS20 SKP2 RPS21 RPS24 RPS23 IKBKE HSPB8 HIKESHI CCAR2 DNAJC2 DNAJC7 ST13;LOC107986532 CRYAB RPS19BP1 HSPA4L HSPA14 HSPA13 DNAJB1 PDGFA HSPH1 BAG5 MAFK AREG DNAJB6 NFE2L2 BAG3 BAG1 HSPA1L HSPA4 HSPA6 HSPA12A EEF1A1 HSPA12B RPS27L RPS15A RPS3 RPS2 STAT1 FAU ATF3 VCP-1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA MAFG ACD TINF2 TERF2 POT1 CREB3 DCSTAMP TERF2IP CREB3L3 TERF1-1 CREB3L4 CREB3L1 CREB3L2 CREBRF NLRP3 CAPZB SQSTM1 GSK3A HSP90AB1 RPS4X PDPK1 RPS3A HBD;HBB IL1A CAPZA1 CAPZA2 VHL IFNB1-4 HIRA EIF2S2 EIF2S3;EIF2S3B EIF2S1 CALM3;CALM1 ATP6V1H LMNB1 ATF5 PPP2R2A;PPP2R2D NPRL2 NPRL3 EIF2AK1 GNGT1 EIF2AK4 ANXA2 H1-0 H1-3 H1-2 H1-5 SOD2 H1-4 SOD1 NOX5 EXTL1 EGLN1 EGLN3 EGLN2 CASTOR1 WTIP CASTOR2 ERO1A FBXL17 SESN1 BACH1 MAP3K5 MUL1 FLT4 ARFGAP1 IMPACT CCNE2 HM13 CCNE1 SH3BP4 SRPRB-1 SLC7A11 NUDT2 MT2A PIEZO1 PREB KDELR3 OMA1 DELE1 FKBP14 HERPUD1 MYDGF MINK1 DEPDC5 RAMP2 GNG10 YIF1A HDGF GNG2 ETS2 GNG5 ERN1 GNG4 HTRA2 GNA11 CACNA1H GNG8 GCN1 HMGA2 MT3 CABIN1 GOSR2 SOD3 CCS BMT2 TSPYL2 DDX11 ASF1A SEH1L GNG13 ABCF2-H2BE1;ABCF2 GNAQ PRDX3 GNB2 SSR1 ATF2 WDR59 GNB1 PRDX6 ADM GNB4 HIF3A GNB3 MIOS KAT5 WDR24 UBN1 GNB5 CDKN2D CDKN2C EPO CDH5 ERF RRAGA TNIK RRAGC CALCRL RRAGB IGFBP7 WFS1 RRAGD TPP1 SRXN1 HIF1AN GPX6 PRKCI GPX5 MAPKAP1 GPX8 PRDX2 GPX7 WIPI1 TFDP1 CTDSP2 PRDX1 TFDP2 PECAM1 CEBPG CACNG7 DNAJB9 FNIP1 FNIP2 TXNRD2 DNAJA4 E2F1 LONP1 E2F3 C12orf66 LIMD1 UBXN7 JUN ATM ITFG2 KPTN MAP4K4 ATR TATDN2 MAPK7 SZT2 CDKN1A PDIA6 CDKN1B PDIA5 DPP3 KLHDC3 DNAJA1-1 BRCA1 SRPRA FLCN RPTOR ATF6B FOS EPAS1 RICTOR ATF4 STAP2 PTPN1 RPA1 PTK6 RPA2 NPLOC4 CDK4 CDK2 UFD1 RPA3 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 MRE11 SESN2 NBN MAPKAPK5 MDM2-2 SLC38A9 ITGAV MAP2K6 PPP1R15A RHEB MDM4 PRR5 MLST8 FKBP4 MTOR RAD50 TRPV4 NRIP1 LY96 SHC1-1 TLR4 UBE2D3;UBE2D2 NFKBIA MAPK1 MAPK3 GRB10 P4HB APOB EP400 CCNA2-1 CCNA1 KDM6B CLOCK GSTP1 RPL12-1 SYVN1 EDEM1-1 DYNC1LI1 DYNC1LI2 NRF1 NPAS2 AKT1S1 SP1 HYOU1 E2F2 PRKAA2 KDR PKN2 DNAJB11 NCF1 NCF2 NCF4 TALDO1 TRIB3 STIP1 COX7B COX7C DNAJA2 COX8A COX8C TLN1 COX5B LMNA COX5A COX6C COX6A1 COX6A2 TXN2 PTK2 COX6B2 COX6B1 NOX4 CALR-1 HIGD1A PGRMC2 CA9 SEC31A DYNC1I1 TGS1 RORA NR3C1 ESR1 VCL NR3C2 AR RXRA CARM1 PGR DCTN1 PPARA TP53 HBA2;HBA1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYBB CYBA JMJD7-PLA2G4B;PLA2G4B CSNK2A2 HMOX1 HMOX2 NR1D1 CSNK2B RPL5-1 BAG4 BAG2 MTF1 TKT ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME UGT1A1;UGT1A6 GLYATL3 ACSM5 ACSM4 SLC16A1 ACSM2A;ACSM2B GLYAT UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CES2 CES1 CYP2D6;LOC107987479;LOC107987478-1 ALB CYP2C9;CYP2C19 UGT2A1 BSG CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 BCHE ABCC3 ABCC2 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters ARNTL CLOCK CREBBP KMT2A SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease FGF20 FRS2 NCBP1 GAB1 SOS1 FGF23 PIK3CA FGFR2 FGF2 POLR2E FGF7 POLR2F POLR2H GTF2F1 FGF22 GTF2F2 FGF3 FGF10 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J;POLR2J2;POLR2J3 NCBP2-1 PLCG1 HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 SPDL1 NUP43 PSMD12 PSMD11 PSMD14 PSMD13 RANBP2 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 NSL1 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NUP37 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 KNL1 PSMC1 ZW10 CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 CKAP5 RCC2 ZWINT XPO1 UBA52 AHCTF1 PAFAH1B1 DYNC1I2 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C RPS27A PPP2R1B CLASP1 PPP2R5E UBB;UBC DYNC1H1 NDE1 PLK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPO NUP160 CENPP NUP85 CENPQ ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 CLIP1 MAD1L1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP SEC13 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs ACTR1A DNAJB1 DYNC1LI1 DYNC1LI2 HSPA1L DNAJA1-1 HSP90AA1 PTGES3-1 DYNC1I1 CAPZA3 ACTR10 CAPZB HSPA1A;HSPA1B HSPA2 FKBP5 DNAJA2 NR3C1 DYNC1I2 DCTN2 NR3C2 DCTN6 HSP90AB1 DCTN5 DCTN3 DCTN4 AR PGR DCTN1 HSPA8 DYNC1H1 STIP1 CAPZA1 FKBP4 DNAJA4 CAPZA2 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines ACTL6A SMARCC1 SMARCC2 H2AJ WDR77 COPRS CCND1 RBBP7 PRMT5 SMARCE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JAK2 PRMT6 RPS2 PBRM1 PRMT7 ACTL6B PRMT3 SMARCA2 SMARCA4 WDR5 CDK4 H2AC20 H2AB2;H2AB3;H2AB1 DNMT3A CARM1 H2AZ2;H2AZ1 ARID1A ARID1B H2AC16;H2AC11 H2AC4 SMARCD1 SMARCB1 SMARCD2 ARID2 PRMT1 SMARCD3 H2AC14 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells RASGRP3 HRAS RASGRP1 NRAS APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins TJP2 DSP CDH1 CASP3 DSG2 OCLN-1 TJP1 DSG1 PKP1 CTNNB1 DSG3 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response ABL1 RBX1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MDC1 UBE2N KDM4A H2BC21 PSMD12 KDM4B EYA1 KAT5 CHEK2 PSMD11 SMARCA5 PSMD14 PSMD13 SUMO1 PSMA7 PHF6 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 UBE2V2 ADRM1 BARD1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 TP53BP1 PSMC6 PSMA4 RAD50 BAZ1B PSMC3 PSMA1 PSMC4 PSMC1 BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 BABAM1 BABAM2 UIMC1 ABRAXAS1 UBXN1 RNF8 BRCC3 APBB1 H2BC15;H2BC3;H2BC11;H2BC12 EYA2 H2BC5 EYA3 EYA4 BAP1 UBA52 PPP5C H2BC1 DDB1 HERC2 NSD2 RPS27A CUL4A KPNA2 UBB;UBC MRE11 NBN CUL4B MAPK8 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation AHCYL1 ITPR1 ITPR2 CALM3;CALM1 PPP3CA PPP3CB ITPR3 PPP3R1 NFATC2 NFATC3 NFATC1 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage APAF1 CASP3 CASP9 CASP7 CYCS-1 XIAP CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD TRADD FASLG TRAF2 CASP8 TNFSF10 FAS RIPK1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD TRADD FASLG TRAF2 CASP8 TNFSF10 FAS RIPK1 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 P2RX6 ITPR1 P2RX5 ITPR2 P2RX3 STIM1 ITPR3 P2RX2 P2RX1 ORAI2 ORAI1 P2RX7 P2RX4 TRPC7 TRPC6 TRPC3 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins SUMO1 RANGAP1 UBE2I GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER RPA1 RPA2 POLD3 POLD4 RPA3 POLD2 RFC5 XRCC1 RPS27A RFC3 LIG1 RFC4 POLE4 RFC2 UBB;UBC POLK POLE POLE2 RFC1 POLE3 POLD1 LIG3 PCNA UBA52 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport ABCG5 ABCC5 ABCC6 ABCC9 ABCA6 DERL3 DERL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 ABCB7 PSMB6 ABCD1 PSMB7 PSMD6 ABCB4 PSMB4 PSMD7 ERLEC1 PSMB5 ABCB1 PSMB2 PSMB3 PSMD2 PSMD3 ABCA12 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 APOA1 EIF2S2 EIF2S3;EIF2S3B CFTR KCNJ11 EIF2S1 PEX19 ABCB6 ABCA3 UBA52 ABCA4 ERLIN1 ERLIN2 ABCD2 ABCC10 ABCC4 PEX3 ABCD3 ABCG4 ABCB5 VCP-1 ABCB8 RPS27A ABCB9 DERL2 ABCF1 ABCA2 RNF5 UBB;UBC ABCA5 ABCA9 OS9 ABCA7 ABCA8 ABCB10 ABCG1 RNF185 ABCC3 ABCC1 ABCG8 ABCC2 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry HSPG2 GPC6 FURIN LY96 RAB5B AGRN NCL-1 RAB5C SDC1 CD14 TLR4 RAB5A EGFR GPC1 SDC4 GPC3 SDC2 IGF1R GPC2 SDC3 GPC5 CX3CR1 GPC4 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease XRN1 LSM5 LSM4 LSM3 LSM2 DCP2-1 LSM7 LSM6 DDX6 LSM1 PATL1 DCP1A EDC3 EDC4 DCP1B RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants KRAS HRAS NRAS RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs FLNA MYL6 PPP1R12B LIMK1 MYH14 PAK1 MYH11 RAC1 NF2 MYH10 PPP1R12A CDC42 PAK3 CALM3;CALM1 MYL12B MYLK CTTN MYH9 PPP1CB PAK2 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias ABCC8 KCNJ11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD MMADHC MMACHC CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) C3-1 TXN CTSG HMOX1 NLRP3 HSP90AB1 RELA MEFV NFKB2 PYCARD NT5E P2RX7 PSTPIP1 C3AR1 IL18 CASP1 IL1A IL1B TXNIP P2RX4 SUGT1 NFKB1 GSDMD ENTPD1 ENTPD5 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA MIGA2 PLA2G4A MIGA1 GPD1L-1 GNPAT PLA2G1B GPD2 AGPAT1 GPD1 AGPAT2 ALPG;ALPP;ALPI-1 AGPAT3 PLA2R1 AGPAT4 GPAT4 GPAT3 GPAT2 PLD6 PLA2G5 PLA2G10;LOC100652777 PLD1 PLA2G2F PLA2G2D PLD2 PLA2G2E DDHD2 DDHD1 GPAM LPCAT4 LPCAT1 LCLAT1 ACP6 AGPAT5-1 PLA2G2A-1 LIPI PLA2G12A LIPH JMJD7-PLA2G4B;PLA2G4B PLA2G4D CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm MIXL1 SMAD2;SMAD3 FOXA2 CTNNB1 TCF7L2 SMAD4 GATA6 GATA4 CDH1 CXCR4 EOMES TBXT SOX17 GSC METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se MAT1A GNMT SCLY NNMT AHCY CBS;CBSL HNMT CTH ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors ADCYAP1R1 NGF ADORA2A NTRK1 ADCYAP1 NTRK2 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants FLT3 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K VKORC1 UBIAD1 VKORC1L1 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib CDC37 ERBB2 ERBIN HSP90AA1 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels HDAC1 GPRIN1 MET PTPN1 OPRK1 GRIA2 GRIN2A GRIN2B TRPC3 OPRM1 FKBP5 PTPN4 HDAC2 SIN3A DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SLC35D1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol NR1H4 CYP8B1 CYP27A1 RXRA CYP7A1 AKR1D1 CYP7B1 NCOA1 NCOA2 HSD3B7 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts NR1H4 CYP8B1 SLC27A2 SLC27A5 CYP46A1 OSBP ACOX2 CYP7B1 HSD3B7 CH25H RXRA AMACR CYP7A1 OSBPL1A OSBPL9 BAAT OSBPL7 CYP39A1 ABCB11 OSBPL6 ABCD3 HSD17B4 OSBPL3 OSBPL2 ACOT8 CYP27A1 AKR1D1 NCOA1 NCOA2 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 CASP3 PAK2 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) KCNK9 KCNK3 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation LTF DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FLRT2 FLRT3 FLRT1 FGF2 FGF22 FGF3 FGF10 PLCG1 HRAS PIK3R1 FGF1 FGF6 FRS3 FGF4 NRAS FGF9 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils PXDN LOXL1 LOXL2 BMP1 TLL2 TLL1 PCOLCE LOX LOXL3 LOXL4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) SOS1 ADRA2C MPL ADRA2A THPO ADRA2B SHC1-1 ITGB3 RASGRP2 CRK RASGRP1 PTK2 FGB AKT1 FGA GP1BB GP1BA FGG F2 RAPGEF3 ITGA2B PTPN1 RAPGEF4 TLN1 VWF PDPK1 BCAR1 SRC FN1 GP5 SYK GP9 RAP1A CSK RAP1B APBB1IP IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R IGF2 SOS1 HRAS IGF1R IGF1 NRAS SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 PSMB6 DNA2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 PCNA UBA52 CUL1 RPA1 RPA2 CDK2 RPA3 RPS27A UBB;UBC RBX1 POLD1 RFC5 RFC3 RFC4 RFC2 LIG1 POLE RFC1 ANAPC15 ANAPC16 UBE2D1 GINS1 GINS2 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 POLD3 GINS3 CDC26 GINS4 CDC27 MCM3 POLD4 MCM4 POLD2 ANAPC7 MCM5 MCM6 UBE2C MCM2 POLE4 UBE2E1 FEN1 UBE2S CDC16 CCNE2 ANAPC4 POLE2 CCNE1 ANAPC5 ANAPC1 POLE3 ANAPC2 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 KDM1A AR KLK3;KLK2 H2AC20 KDM4C-1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 NCOA2 H2BC5 PKN1 H2BC1 H2AC14 H2BC21 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH GZMH;GZMB-1 DLL4 NEURL1 HDAC11 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP DTX1 HDAC5 HDAC8 DTX2 PSMD12 DTX4 HDAC9 NOTCH1 ST3GAL4 DNER PSMD11 HDAC6 DLK1 PSMD14 CNTN1 HDAC7 PSMD13 SMAD2;SMAD3 RBPJ ST3GAL3 DLL1 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 LFNG B4GALT1 PSMB6 POGLUT1 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 POFUT1 PRKCI PSMB5 TMED2-1 PSMB2 ARRB2 SIRT6 PSMB3 PSMD2 TFDP1 EGF PSMD3 ELF3 TFDP2 PSMB1 PSMD1 MFNG EGFR MAML3 NOTCH2 NOTCH3 ADRM1 NOTCH4 SEL1L PSMC2-1 RFNG E2F1 PSMA2-1 PSMA5 E2F3 ST3GAL6 SEM1 RAB6A PSMA6 JUN PSMC5 SNW1 PSMA3 PSMC6 MAMLD1 PSMA4 MIB2 PSMC3 PSMA1 PSMC4 NCOR2 PSMC1 SKP1 KAT2B H2AJ KAT2A NCOR1 HES5 TLE4 TLE2 TLE1 H2BC5 AKT1 UBA52 H2BC1 STAT1 CUL1 YWHAZ HEYL EP300 RPS27A PSEN2 H2AC4 UBB;UBC APH1A TBL1XR1 APH1B RBX1 FABP7 WWC1 PBX1 CDK8 DLGAP5 PTCRA ACTA2 FCER2 NUMB PSENEN TACC3 HDAC4 MIB1 HEY1 HEY2 JAG1 ADAM10 H2BC21 ADAM17 ITCH JAG2 PSEN1 H2AZ2;H2AZ1 NCSTN TP53 ELANE NEURL1B HIF1A YBX1 MDK MYC HDAC2 HDAC3 HDAC1 HES1 TNRC6C MOV10 TNRC6A-1 HDAC10 AGO4 AGO2 AGO3;AGO1 WWP2 ATP2A3 TNRC6B ATP2A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 ATP2A1 RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 ARRB1 NBEA PLXND1 FURIN FLT4 H2AC14 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway GJB2 GJA1 GJB1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD TBXAS1 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis NGF RHOA LINGO1 ARHGDIA MAG OMG RTN4 NGFR MCF2 INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling STAT1 IL21 STAT5A STAT3 IL21R STAT5B IL2RG JAK1 STAT4 JAK3 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions PIK3CA WASL ACTN1 SPTAN1 IQGAP1 PIK3R2 PIK3CB ACTN2 KIRREL3 CASK PIK3R1 NCK2 SPTBN1 KIRREL1 FYN KIRREL2 NCK1 ACTN3 MAGI2 ACTN4 CD2AP NPHS1 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud GFRA1 NPNT ITGB1 PAX2 ROBO2 RET GREM1 FOXC2 BMP4 FOXC1 SIX1 GDNF HOXD11 ITGA8 HOXC11 HOXA11 SALL1 WNT11 SIX2 SLIT2 EYA1 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB-1 HADHA HADH ECHS1 ACADS SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin PCSK1 PLA2G7 CRHR2 IGF1 LEP ACHE MBOAT4 SPCS3 KLF4 INS;INS-IGF2 SPCS2 SPCS1 SEC11A SEC11C BCHE GCG NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation ASB10 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 NFE2L2 PSMA1 PSMC4 PSMC1 SKP1 FBXW11 SENP8 UCHL3 UBA52 CUL1 VCP-1 RPS27A UBB;UBC RBX1 SQSTM1 LRRC41 GPS1 CUL3 VHL KBTBD7 DCAF13 FBXO32 DCAF7 FBXO4 FBXO6 FBXW4 FBXW10;CDRT1 FBXW5 FBXW7 MUL1 FBXW9 ELOC-1 FBXW2 ELOB COPS4 COPS2 CISH SOCS2 HIF3A FBXL3 FBXL5 COP1 UBXN7 CDKN1A UBE2D3-1 DPP3 BRCA1 DDB2 LRR1 EPAS1 CCNF KEAP1 SOCS3 NPLOC4 AMER1 UFD1 FBXO7 FBXO9 WSB1 FBXO2 FBXL8 FBXL4 FBXL7 GAN GPR75-ASB3;ASB3-1 KLHL2 KLHL3 KLHL9 SPSB2 SPSB1 KLHL5 KBTBD8 SPSB4 FBXO27 DCAF8 DCAF5 DCAF6 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 OBSL1 FBXO21 WDR5 DCUN1D5 FBXO22 DCUN1D3 DCUN1D4 DCUN1D1 COMMD8 FBXW12 COMMD9 KCTD6 PUM2 FBXW8 DDA1 ANKRD9 FBXO17 COMMD2 COMMD3 FBXO15 COMMD1 COMMD6 LMO7 COMMD7 FBXO10 COMMD4 FBXO11 SPSB3 KLHL41 CCDC8 KCTD7 CUL9 BIRC5 KLHL42 UBD HIF1A NAE1 CUL7 SOCS6 CUL5 SOCS5 WDTC1 CCDC22 CUL2 DCUN1D2-1 COMMD10 KLHL11 DTL KLHL13 TULP4 DCAF16 FBXO44 DCAF17 FBXO41 CAND1 FBXO40 FEM1C BTBD1 DCAF10 DCAF11 UBE2F FEM1A RBBP5 FEM1B NEURL2 KLHL25 ERCC8 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 RBBP7 FBXO31 UBA3 UBE2D3;UBE2D2 DDB1 KBTBD13 UBE2D1 COPS7B COPS7A ASB13 ASB14 CUL4A COPS3 COPS6 ASB11 COPS5 RNF7 ASB12 ASB17 COPS8 ASB18 FBXL22 CUL4B ASB15 ASB16 FBXL20 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 SOCS3 STAP2 STAT3 PTK6 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria KHK LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 DPEP1 CYSLTR1 CYSLTR2 GGT1 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins DPM1 DPM2 DPM3 IPO7 DNAJC10 P4HB SCAP KPNB1 OST4 SEC11A UBE2I RPN2 SEC11C OSTC STT3A RPN1 STT3B SUMO1 DNAJC3-1 DDOST KPNA4-1 DAD1 HYOU1 ACOT2;ACOT1 SPCS3 SPCS2 SPCS1 MAGT1 PRKG2 APOA1 KPNA1 HSPA5 CANX P4HA1 P4HA2 XPO1 P4HA3 DNAJB11 UBA52 CALR-1 KPNA7 KPNA5 RPS27A NMT1 KPNA3 TUSC3 KPNA2 UBB;UBC PDIA3 TMEM258 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport MKLN1 MPC1 MPC2 SURF1 ADHFE1 RMND5B RMND5A SCO1 SCO2 HSCB TMEM126B MPC1L COA3 ACAD9 SFXN4 NUBPL IDH3B IDH3A COA5 PC PDHB SDHAF2 ATP5MC2 ATP5MC3 SDHAF3 IDH3G SDHAF1 ATP5MC1 UBA52 SDHAF4 L2HGDH CYC1 NDUFV3 NDUFV2 ISCA2 NDUFV1 ISCA1 DLST PDK3 RPS27A PDK2 GID4 UQCRFS1 PDK1 GID8 PDHX UBB;UBC NDUFS8 SUCLG2 NEK1 NDUFS7 SUCLG1 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 UQCRB PM20D1 LDHA;LDHC C12orf73 GOT1-1 UQCRQ ACO2 PDPR ETFA ETFB ATP5PF ATP5PD ATP5PB PDP1 PDP2 FXN ATP5PO NDUFA13 SMIM20 NDUFA11 NDUFA12 NDUFA10 CSKMT FOXRED1 ATP5MJ ATP5MG ATP5ME OGDH UQCC3 GSTZ1 UQCC2 SUCLA2 UQCC1 IDH2 TMEM186 TIMM21 BCS1L TMEM177 PYURF DMAC2L TIMMDC1 ETFDH PDK4 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 MAEA NDUFAF1 NDUFS5-1 LDHAL6B COX7B COX7C GLO1 UQCRC1 UQCRC2 COX8A COX8C MRPS36 COX5B COX5A COX6C CS NDUFAB1 ECSIT TACO1 COX6A1 COX6A2 COQ10A-1 SIRT4 SDHC SDHD SDHA COX6B2 SIRT3 SDHB COX6B1 DLD COX19 GOT2-1 FH DMAC2 NDUFB10 COX15 UCP1 NDUFB11 PET117 COX18 COX17 CMC1 CYCS-1 UCP3 UCP2 HIGD1A COX11 COX14 VDAC1 MDH1 PDHA1 MDH2 HIGD2A SMIM4 LETM1 COX20 LYRM2 TMEM223 LYRM4 LYRM7 NDUFC2;NDUFC2-KCTD14 TRAP1 HCCS ACAT1 FAHD1 NNT TTC19 DLAT COX4I1 COX4I2 ME1 ME3 ARMC8 ME2 NDUFC1 SLC25A18 COX7A2L-1 UQCR11 UQCR10 SLC25A12 SLC25A4 ATP5F1A SLC25A11 ATP5F1B LDHB SLC25A14 SLC25A13 LDHA NDUFB9 NDUFB8 NDUFB7 RANBP9 NDUFB6 ATP5F1C NDUFB5 ATP5F1D NDUFB4 NDUFB3 NDUFB2 NDUFB1 OXA1L COX7A2 SLC25A27 HSPA9 D2HGDH GPT TMEM126A-1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 RAB5IF NDUFA6 COQ10B NDUFA4 NDUFA3 WDR26 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG5 ABCG8 THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome NLRC4 CASP1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes FKBP14 CXXC1 MYDGF TATDN2 PDIA6 YIF1A PDIA5 HDGF KLHDC3 SRPRA SEC31A GOSR2 SHC1-1 TSPYL2 DDX11 ATP6V0D1 ZBTB17 SSR1 DNAJB11 GSK3A TLN1 DNAJC3-1 EXTL1 ACADVL DCTN1 WFS1 PPP2R5B EXTL2 TPP1 HYOU1 SYVN1 LMNA EDEM1-1 ADD1 WIPI1 CTDSP2 EXTL3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARFGAP1 DNAJB9 GFPT1 SRPRB-1 CUL7 JMJD7-PLA2G4B;PLA2G4B PREB KDELR3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade TBK1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 RIPK3 APP NFKB2 IKBKE RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 BIRC2 CHUK BIRC3 OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 TANK MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 NFKBIB SAA2;SAA1 NKIRAS1 TLR3 NKIRAS2 IKBIP TRAF2 TICAM1 CASP8 LRRC14 USP14 RIPK1 NLRC5 TIFA FADD HMGB1-1 UBE2D3;UBE2D2 NFKBIA UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes LPL APOC2 FURIN APOA4 PCSK5 LMF2 MBTPS1 APOA5 LMF1 LIPC CREB3L3 ANGPTL8 PCSK6 ANGPTL3 MBTPS2 FGF21 ANGPTL4 GPIHBP1 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l ALG9 DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair NEIL3 NEIL1 NTHL1 OGG1 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE ABCC6 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants KIT PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 KLB FGF19 FGFR4 PIK3R1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR1C POLR2H POLR1D SSB NFIX NFIA POLR2L NFIB NFIC CRCP SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism PHGDH SDSL PSPH SERINC1 SERINC3 SERINC2 SDS SERINC5 SERINC4 SRR PSAT1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription CDK1 HDAC1 CDT1 CDC6 RBBP4 FBXO5 CCNA1 LIN54 LIN37 DHFR2;DHFR LIN9 LIN52 PCNA TYMS TK1 CDC45 POLA1 E2F4-1 E2F5 E2F6 RRM2-1 TFDP1 RBL2 TFDP2 RBL1 CCNE1 E2F1 ORC1 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation SPINT1 HPN MET SPINT2 HGFAC HGF DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 FGF20 FGF23 FGFR1 FGF6 FGF1 FGF4 FGF9 FGF2 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis MEF2D APOO APOOL MTERF1-1 HELZ2 TFB1M GABPA MED1 TFB2M PPRC1 MTX2 NRF1 SAMM50 TFAM-1 CHCHD3 CHCHD6 HCFC1 POLRMT POLG2 DNAJC11 TMEM11 TWNK PRKAB2 PERM1 MTX1 PPARGC1A IMMT PPARGC1B SSBP1 TGS1 CREBBP ATF2 RXRA CAMK4 PRKAB1 ALAS1 CARM1 PPARA ESRRA ATP5PF ATP5PD ATP5PB NCOA1 NCOA2 NCOA6 PRKAG2 SMARCD3 HDAC3 ATP5PO ATP5F1A ATP5F1B PRKAA2 CRTC1 PRKAG1 ACSS2 PRKAG3 ATP5F1C NCOR1 NR1D1 ATP5F1D ATP5MJ ATP5MG CALM3;CALM1 ATP5ME ATP5MC2 ATP5MC3 SIRT4 SIRT5 IDH2 ATP5MC1 HSPA9 SIRT3 GLUD1;GLUD2 SOD2 CHD9 CYCS-1 TBL1XR1 MAPK14 MEF2C MAPK11 MAPK12 MICOS13 CRTC2 MICOS10 CRTC3 DMAC2L RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 MUS81 C1orf112 EME1-1 BRCA2 RAD51AP1 DNA2 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 PALB2 SPIDR BRIP1 SLX1A;SLX1B MRE11 NBN BARD1 RBBP8 SEM1 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids CYP2D6;LOC107987479;LOC107987478-1 CYP2F1 CYP4B1 CYP2A13;CYP2A6;CYP2A7-1 CYP2J2-1 CYP4F22 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2B6 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell NPDC1 SLAMF6 SIGLEC5;SIGLEC14 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L KLRB1-1 SH2D1A CD19 CD160 ITGB1 CRTAM SH2D1B PILRA;PILRB TREML1 TREM2 SELL TREML4 KLRC4-KLRK1;KLRK1 TREML2 KLRC4;KLRC3;KLRC2;KLRC1 SIGLEC1 B2M TYROBP RAET1E-1 KLRD1 NECTIN2 CD200 CD22 CD40LG CDH1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD33-1 VCAM1 ITGB2 CD3E CD3D CD3G FCGR3A;FCGR3B FCGR1A C3-1 CD300LF;CD300LD ICAM3 ITGAL CD81 ICAM4 ICAM5 TREM1 PVR SIGLEC10;SIGLEC11;SIGLEC16 CD8B;CD8B2 ITGB7 ITGA4 LAIR1;LAIR2-1 CD96 PIANP CXADR SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 OSCAR JAML CD8A ULBP1-2 IFITM3;IFITM2;IFITM1 CD300E NCR3LG1-1 CD226 HCST CLEC4G NCR1-1 CD1D CD1C CD1B COLEC12 CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 ICAM2 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG CD99 ICAM1 KLRG1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1MW3;OPN1MW2;OPN1MW;OPN1LW PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential KCNJ2 KCNK9 KCNJ12;KCNJ18 KCNK3 KCNJ4 KCNK5 KCNK10 KCNK12 KCNJ14 KCNK6 KCNK13 KCNK7 KCNK15 KCNK16 KCNK1 KCNK18-1 KCNK17 KCNK2 KCNK4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency HLCS MCCC1 PCCB ACACA MCCC2 PC PCCA DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function TTR STRA6 RBP4 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO1 FMO2 FMO3 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly IPO5 HSP90AA1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 CHEK1 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type PTGIS NR1H4 CYP26B1 CYP27B1 CYP26A1 AHR CYP24A1 CYP2S1 CYP7B1 CYP19A1 POMC TBXAS1 FDXR RXRA CYP1B1 CYP7A1 CYP4F22 CYP11B1;CYP11B2 CYP2C18-1 CYP2J2-1 ARNT NCOA1 NCOA2 FDX1 CYP2B6 CYP2W1 CYP8B1 ARNT2 CYP46A1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP4B1 CYP21A2 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP51A1 CYP2E1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP11A1 CYP39A1 AHRR CYP27A1 CYP2F1 CYP2R1 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 POR CYP2U1 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea KCNMB1 STX1A KCNMA1 CAPZB CACNB2 MYH9 CACNA2D2 SNAP25 EPB41L1 SLC17A8 CAPZA1 RIPOR2 CLIC5 CAPZA2 CIB2 PJVK EPS8 PCLO BSN TPRN PLS1 TMC1 ESPN-1 MYO7A SYP TMC2 MYO3B DNAJC5 MYO3A KCNQ4 FSCN2 MYO1C EZR PCDH15 USH1C ATP2B1 CABP2 TWF1 CABP1 LRRC52 ESPNL CDH23 CASK OTOF SPTBN1 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX RAB3A LHFPL5 VAMP2 MSN TMIE USH1G STRC SYN1 MYO15A SPTAN1 CACNA1D GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling ARAF MRAS RAF1 YWHAB BRAF SHOC2 PPP1CB PPP1CC BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) ALOX12 HPGD ALOX5AP ALOX5 LTC4S PTGR1-1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism PDK4 LDHB MKLN1 LDHA RANBP9 PC LDHA;LDHC MPC1 PDHB MPC2 MAEA GSTZ1 LDHAL6B RMND5B RMND5A SIRT4 GLO1 UBA52 FAHD1 GPT DLD MPC1L DLAT PDPR PDK3 RPS27A WDR26 PDK2 GID4 PDK1 GID8 UBB;UBC PDHX ME1 ME3 ME2 ARMC8 VDAC1 PDHA1 NEK1 PDP1 PDP2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a PMM2 CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism PPP1R3C DCXR ABCC5 HKDC1 PXYLP1 LALBA B4GALT6 B4GALT7 B4GALT4 B4GALT5 NDST2 NDST1 SLC26A11 CSGALNACT1 NDST4 NDST3 PRELP CSGALNACT2 SDC4 KERA PGD B3GAT3 SDC2 B3GAT2 PHKA1 SDC3 RPE;RPEL1 B3GAT1 PHKA2 SLC26A2 ST3GAL4 SLC26A1 GNPDA1 GNPDA2 ST3GAL1 AKR1B1 HMMR ST3GAL2 ST3GAL3 HYAL2 SDC1 PHKB AKR1A1 ADPGK PRKACA-1 PPP2R1A CHPF2 CHST6 CHST7 BPGM PC PGM2L1 G6PD GPC1 FUT2 FUT1 GPC3 FUT4 GPC2 CHST1 GPC5 FUT7 FUT9 UBA52 GPC4 NUP214 SLC35B3 CHST2 GPC6 SLC35B2 CHST3 HS6ST1 HS6ST2 HS6ST3 AGRN RPS27A GAPDH-1 UBB;UBC HS3ST3B1 SLC35D2 DERA TKFC RPIA PGK1 GBE1 PRKACB-1 G6PC1 G6PC2 ENO1 G6PC3 ENO2 ENO3 OGN HSPG2 BCAN ENO4 HPSE B4GAT1 PGM2 PGLS GLCE PGM1 NHLRC1 CHST11 PRPS2 NUP107 CHST12 PRPS1 NUP188 CHST15 CHST13 CHST14 CTSV;CTSL NUP210 PHKG1 PHKG2 CALM3;CALM1 NUP93 DCN NUP205 AAAS NUP160 NUP85 CD44 TPR NUP88 NUP155 GALM-2 OMD TALDO1 NUP153 ACAN CRYL1 HK2 HK1 HS2ST1 HK3 NUP62 PCK1 GAPDHS B4GALNT2 ALDH1A1 PCK2 RBKS NDC1 SEC13 NUP133 EXT1 UGP2 EXT2 CHSY3 NUP50 POM121;POM121C FMOD LUM NUP54 CHSY1-1 UXS1 CHPF NAGLU XYLB CHP1 GYG2 GYG1 NUP42 CEMIP KHK NUP43 RAE1 RANBP2 GAA HS3ST3A1 AGL-1 GALE B4GALT1 SLC37A1 NUP35 NUP37 IDUA HEXB NCAN HEXA SLC37A4 BGN ST3GAL6 GLB1L3 GLB1L2 VCAN GLB1L SORD GLB1 HYAL1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB B3GALT2 B3GALT1 PFKL PGAM1 PGAM2 PFKM PFKP HPSE2 SHPK PPP2CB;PPP2CA EXTL2 PPP2R5D HAS1 PPP2R1B HAS3 HAS2 EXTL3 GALK1 EPM2A FBP1 FBP2 GALT PFKFB2 PFKFB1 PFKFB4 STAB2 PFKFB3 GYS2 GYS1 SLC9A1 DSEL HS3ST5 HS3ST6 HS3ST4 HS3ST1 B3GALT4 HS3ST2 B3GALT6 MANBA B3GALT5 GALNS UST XYLT2 B3GNT7 XYLT1 B3GNT4 FAM20B DSE B3GNT3 B3GNT2 ALDOC ALDOB ALDOA SPAM1 GNS ST6GALNAC6 LYVE1 FUT6;FUT5;FUT3 PYGB GPI PYGM PYGL GCKR GCK MAN2B2 TPI1 MAN2B1 B4GALT2 B4GALT3 TKT SLC2A1 SGSH PAPSS2 PAPSS1 SLC17A5 MAN2C1 GLYCTK DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes POLH POLD3 POLD2 RFC5 RPS27A RFC3 RFC4 APEX2 RFC2 UBB;UBC REV1 RFC1 MAD2L2 REV3L PCNA UBA52 POLI TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex HDAC1 CDC6 CDC25A TOP2A RBBP4 MAX E2F4-1 E2F5 TFDP1 RBL2 TFDP2 RBL1 LIN54 LIN37 LIN9 LIN52 MYC PCNA E2F1 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type MMAA MMUT QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants FLT3 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine CBS;CBSL CTH GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 GSK3B UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 CD274 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 COPS5 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation LTF PRKN B2M PSENEN INS;INS-IGF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PRL CALB1 BACE1 MFGE8 H2BC21 NPPA ADAM10 IAPP APCS HSPG2 CALCA TSPAN33 CST3 TSPAN5 SNCA APP ODAM NAT8-2 SNCAIP H2AC20 SORL1 TSPAN15 H2AB2;H2AB3;H2AB1 TSPAN14 H2AZ2;H2AZ1 TGFBI ITM2B NCSTN GGA2 GGA1 GGA3 SAA2;SAA1 USP9X APOA1 APOA4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 UBE2L6 TTR H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 FGA UBA52 H2BC1 FURIN LYZ-1 RPS27A H2AC4 UBB;UBC APH1A GSN APH1B APOE SIAH2 SIAH1 H2AC14 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling CETP MTTP P4HB APOB APOF FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases SYK FLT3LG HCK LCK FYN FLT3 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex DTL RBX1 UBE2B RAD18 POLE RFC1 POLD1 PCNA UBA52 DDB1 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 USP1 RPS27A RFC5 RFC3 RFC4 POLE4 CUL4A UBB;UBC RFC2 POLE2 POLE3 CUL4B WDR48 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 PTTG1;PTTG2 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization COL6A2 COL4A3 COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 COL6A6 COL4A5 COL6A5 COL16A1 COL12A1 COL25A1 COL11A1 COL11A2 COL28A1 COL1A1 COL24A1 COL1A2 COL22A1 COL3A1 COL5A1 COL5A3 COL7A1 COL23A1 COL5A2 COL20A1 COL15A1 COL17A1 COL19A1 COL13A1 COL26A1 COL10A1 COL9A1 COL27A1 COL9A3 COL9A2 COL18A1 COL14A1 COL2A1 COL4A2 COL4A1 COL4A4 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates TXN CTPS2 CTPS1 NME4-1 GLRX AK4-1 TXNRD1 DCTD CMPK1 DTYMK AK1 RRM1 AK2 GUK1 TYMS AK5 AK6 AK7 NME2 AK8 AK9 NME3 NME1 NME6 RRM2-1 RRM2B NUDT13 DCTPP1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling SOS1 MET MUC20 HRAS RANBP9 NRAS RANBP10 HGF TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest CDK1 SFN AURKA BAX CCNB1 CARM1 EP300 ZNF385A E2F4-1 TP53 TFDP1 RBL2 TFDP2 RBL1 PRMT1 PCNA GADD45A CDC25C IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 PIK3R4 THEM4 PDPK1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism NUDT12 NMNAT3 PARP9 NMNAT2 BST1 QPRT PARP8 NMNAT1 NADK NAXE SLC22A13 SLC25A51;SLC25A52 SLC5A8 NMRK2 NMRK1 NNMT NADSYN1 PARP16 PARP14 NT5E CD38 PARP10 NAXD NADK2 NAMPT NAPRT PARP6 PARP4 RNLS LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PARVA ITGB1 PXN ILK CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication PTK2B CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 WASL PSMA7 PSMD8 PSMB6 PSMB7 ITGB4 PSMD6 PSMB4 PSMD7 ILK PARVA PSMB5 TESK1 PSMB2 CLDN2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 CLDN6 CLDN4 PSMB1 PSMD1 CLDN3 CLDN9 CLDN8 JAK1 CLDN7 ADRM1 RSU1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PARVB PSMA5 XIAP CLDN23-1 SEM1 LIMS4;LIMS1 PSMA6 CLDN20 PSMC5 TYK2 CLDN11 PSMA3 CLDN10 PSMC6 CTNND1 MTBP PSMA4 CLDN15 RACK1 CLDN14 DST CBLL1 CLDN12 PSMC3 PSMA1 CLDN19 EPS15 CLDN18 PSMC4 CLDN17 PSMC1 ITGA6 CD47 CTNNB1 BIRC2 CLDN16 FLNC ADAM33 PLEC CANX LIMS2 CD151 CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 SKAP2-2 ADAM19 FBLIM1 SIRPA;SIRPB1;SIRPG CDH24 SDK1 SDK2 SIRPB1 CLDN22;CLDN24-1 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 PARD6G NECTIN4 MPP5 NECTIN3 NECTIN1 RPS27A CRB3 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 CLDN5 SNAI2 TYROBP CDH1 JUP OST4 OSTC FERMT2 STT3A ANG JAK2 SP1 PRKCSH COL17A1 F11R DDOST PARD3 DAD1 CDC42 IL6ST FYN LAMC2 GANAB CTSS FLNA PTPN11 FARP2 CTSB CTSV;CTSL ACTN2 CASK IL6R LAMA3 FURIN LAMB3 CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 NCK2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A NCK1 SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 PARD6B PARD6A PRKCI IQGAP1 SPCS3 SPCS2 SPCS1 BANP SIRT1 ACTN1 RAC1 H2AJ TCF12 CLDN1 ANGPTL4 ELMO1 SPTBN1 DOCK1 SUZ12 PTK2 H2BC5 H2BC1 PXN SOX10 DNM2 MPHOSPH8 SPTAN1 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 ARHGEF6 ITGB1 MDM2-2 CTNNA1 KLF4 STRAP KIRREL3 KIRREL1 KIRREL2 ACTN3 TWIST2 MAGI2 ACTN4 CD2AP NPHS1 H2BC21 VCL RNF19B VASP EED FYB1 WT1 H2AZ2;H2AZ1 ARID1A PIK3R2 PIK3CB PIK3R1 MYC HDAC2 MYCN HDAC1 PIK3CA PTPN6 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 PATJ POMT1 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A TPST2 F2 TPST1 F8 F9 VWF F10 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins MGAT2 GLB1 ALG8 ALG9 B4GALT1 ALG6 ALG2 ALG3 ALG1 RFT1 MAN1B1 CTSA MOGS MPDU1 NEU1 DPAGT1 ALG14 ALG12 ALG11 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 RHOG RHOA KIF5B KLC1 KIF5A KLC4 KLC3 KLC2 RAC1 KTN1 CDC42 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A WRN RAD9B KAT5 RAD9A RPA1 HUS1 RPA2 EXO1 BRCA2 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 RFC2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis PARP1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium TTC8 BBS7 BBS5 BBS4 MKKS LZTFL1 ARL6 SMO CCT3 SSTR3 MCHR1 BBS10 CCT2 BBS12 CCT8 CCT5 CCT4 BBS2 BBS1 RAB3IP BBIP1 TCP1 BBS9 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs ABL1 ARPC4 ARPC5 WAS NCKIPSD ARPC2 ARPC3 RAC1 BTK ACTB-1 ABI2 NCKAP1L ABI1 NCK1 ACTR2 PTK2 ARPC1B ARPC1A ACTR3-1 WASL CYFIP2 CYFIP1 NCKAP1 ACTG1 WASF1-1 CDC42 WIPF1 WIPF2 WIPF3 MAPK1 WASF2 MAPK3 WASF3 BAIAP2 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events NUP133 VPS37C VPS37D VPS37A VPS37B NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CEBPD VPS4A H2BC18 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MVB12B MVB12A NUP43 H2BC21 RAE1 RANBP2 H2AC20 CHMP1A UBAP1 NUP35 NUP37 VPS36 SNF8 VPS25 NUP107 NUP188 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 H2BC15;H2BC3;H2BC11;H2BC12 AAAS H2BC5 NUP160 NUP85 H2BC1 NUP214 TPR NUP88 NUP155 NUP153 CHMP2B CHMP2A H2AC16;H2AC11 H2AC4 NUP62 HNRNPK NDC1 H2AC14 SEC13 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins NUP133 TOP2A TOP2B NUP107 NUP188 RANGAP1 NUP50 POM121;POM121C CDCA8 NUP54 TOP1 NUP210 NUP93 PIAS4 PIAS3 NUP205 NUP42 UBE2I AAAS PCNA NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 AURKA SUMO1 SUMO3 SUMO2 NUP153 INCENP NUP35 NUP62 BIRC5 NUP37 AURKB NDC1 SEC13 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD GCLC GCLM CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis ISL1 CTNNB1 FOXO4 KAT2A HEY1 HEY2 KAT5 LEF1 WDR5 MESP1 TBX20 HAND2 LDB1 SMYD1 TBX1 SRF MYOCD HAND1 SMAD1 SMAD4 GATA6 TBX5 GATA4 MEF2C NKX2-5 EOMES TBXT TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades S100A8 TLR2 TBK1 APOB DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 ITGB2 SOCS1 PIK3R4 RIPK3 APP NFKB2 GSDME TLR6 TLR5 LGMN IKBKE CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 ECSIT BIRC2 CHUK BIRC3 BTK OPTN-1 TLR8 TLR7 FBXW11 IKBKB IKBKG FOS UBA52 DNM1 DNM2 CUL1 DNM3 TANK MAPKAPK2 LBP TLR10 PPP2CB;PPP2CA CD180 PPP2R5D ATF1 LY86 RPS27A ELK1 ITGAM RPS6KA3 PPP2R1B S100A1 EEA1 RPS6KA5 TASL RPS6KA2 IRF5 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 GSDMD MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 HSP90B1 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 RBSN IRF3 TRAF3 TRAF6 IRF7 TP53 PIK3C3 NOD1 NOD2 CTSS ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 CTSK PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 TLR3 NKIRAS2 LY96 IKBIP IRAK4 PLCG2 TRAF2 PELI1 TICAM1 TLR9 CASP8 CTSB LRRC14 CTSV;CTSL USP14 PELI3 RIPK1 PELI2 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 MAP3K1 CNPY3 SIGIRR IRAK3 FGB UBE2D3;UBE2D2 NFKBIA FGA FGG UNC93B1 UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SLC15A4 PTPN4 TLR1 BPI S100A9 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFB2M TFAM-1 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJB2 GJA1 GJB1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 PRIM1 H2AC20 PSMA7 POLA1 PSMD8 POLA2 H2AB2;H2AB3;H2AB1 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 H2AJ H2BC5 UBA52 H2BC1 RPA1 RPA2 CDK2 RPA3 RPS27A H2AC4 UBB;UBC KPNA6 MCM10 DBF4 KPNB1 H2BC21 H2AZ2;H2AZ1 KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLE H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 MCM6 UBE2C MCM2 POLE4 UBE2E1 UBE2S CDC16 ANAPC4 POLE2 ANAPC5 ANAPC1 POLE3 ANAPC2 H2AC14 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation HSP90AB1 DNAJB1 CAMK2G MTOR HSPA1L HSBP1 HSF1 MLST8 HSP90AA1 RPTOR EP300 PTGES3-1 HSPA8 HSPB8 AKT1S1 HSPA1A;HSPA1B HSPA2 CAMK2B CREBBP FKBP4 CAMK2D CAMK2A CRYAB TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins FUT8 MAN2A1 GSK3B ST6GAL1 MOGS OST4 UBE2I RPN2 OSTC STT3A RPN1 CSNK1A1 STT3B GSK3A ST3GAL4 ST6GALNAC2 PRKCSH ST3GAL1 MGAT4A-1 ST3GAL2 ST3GAL3 SUMO1 SRPK2 EDEM2 PARP16 DDOST PARP14 SRPK1 PARP10 DAD1 MAN1B1 ST6GALNAC3 ST6GALNAC4 MAGT1 PARP6 PARP4 GANAB PRMT1 GALNT1 PARP9 MGAT4C MGAT4B PARP8 CANX ZDHHC20 MGAT5 MGAT1 UBA52 MGAT2 ZDHHC9 RPS27A TUSC3 UBB;UBC ZDHHC5 ZDHHC8 ZDHHC2 GOLGA7-1 ZDHHC3 TMEM258 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 EPO STAT5A EPOR STAT5B IRS2 JAK2 LYN REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome RB1 DDX5 ZCRB1 VHL SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions FGFR2 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose NR1H3 RXRA PLIN1 RXRB NR1H2 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP-1 CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily TCF4 PHF5A SNRPF SNRPD2 SNRPD1 SNRPN SNRPB CTR9 SNRPD3 RTF1 MYOG PAF1 DHX15 MYOD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 SNRPE-2 DDX46 DDX42 RBM17 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 SSRP1 SMNDC1 U2SURP SNRPG-2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 H2AJ SF3A3 SF3A1 CDC73 SUPT16H TCF12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SF3A2 LEO1 CHERP SF3B1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 PUF60 SNRPB2 SNRPA1 H2AC4 WDR61 CHD2 H2AC14 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives ALOX12 GPX4 ALOXE3 ALOX12B GPX1 ALOX15 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport ATP6V0B TF ATP6V1B2 ATP6V0C ATP6V1B1 ATP6V1G3 LCN2 ACO1 ATP6V0E2;ATP6V0E1 FBXL5 MCOLN1 CAND1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC40A1 ATP6V1G2 HMOX1 HEPH SKP1 HMOX2 ATP6V1H ATP6V0D1 ATP6V0D2 ABCG2 ATP6V1A SLC46A1 UBA52 ATP6V0A2 FTH1 ATP6V0A4 CP CUL1 ATP6V1D ATP6V1C1 ATP6V1F SLC11A2 ATP6V0A1 ATP6V1C2 ATP6AP1 RPS27A TFRC UBB;UBC STEAP3 STEAP4 HFE TCIRG1 SLC22A17 GLRX3 TFR2 FTL-1 IREB2 FTMT CYBRD1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium CYS1 UNC119B ARL3 RP2 NPHP3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B CDKN1A TFAP2A TFAP2C MYC TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation S100A12 NFKBIB APP SAA2;SAA1 RELA NKIRAS1 NKIRAS2 NFKB2 TRAF2 CHUK DDX58 TRAF6 NFKB1 HMGB1-1 MAP3K1 RNF135 IFIH1 IKBKB TRIM25 MAVS IKBKG NFKBIA AGER CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle GJA1 ARHGEF7 SRGAP2 RHOQ STOM PAK1 IQGAP3 SLC4A7 SNAP23 PAK4 GIT2 JUP CAV1 PLEKHG3 MPP7 DLC1 TRIP10 ARHGAP1 WASL CDC42EP4 SYDE1 CDC42EP3 CDC42 CDC42EP2 IQGAP1 CDC42EP1 ARL13B VAMP3 ARHGAP5 CDC42BPB ARHGAP21 CDC42BPA CPNE8 ARHGAP17 OPHN1 ARHGAP35 SCRIB WWP2 CFTR VANGL1 DEPDC1B RAB7A ARHGAP26 ARHGAP33 GOPC ARHGAP32 PAK2 DIAPH3 GIT1 TFRC LAMTOR1 ITSN1 STEAP3 PREX1 SLC1A5 FNBP1 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription CSNK2A1;CSNK2A3 HDAC11 BMI1 YY1 RING1 MAF HDAC5 HDAC9 RNF2 HDAC6 HDAC7 CBX8 GPAM CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 NFATC2 POU2F2 PHC3 NFYA-1 ERBB2 EGFR YWHAE PRKACA-1 LBR PPP2R1A YWHAG SKP1 TCF7 CDC73 LEO1 UBA52 CUL1 AURKA CCNB1 RPS27A UBB;UBC MEF2C CENPJ SPI1 TGIF1-1 CDK1 ZNF287 ZNF18 RBFOX1 RBFOX3 BCL2L11 TXN ZNF282 ZNF10 ZNF12 CLDN5 PMAIP1 DDIT3 ZNF23 BID ZNF25 BBC3 GRIN2A ZNF268 ZNF263 ABCA6 NR2F1 NR0B2 GRIN2B NR2F6 COL1A1 INS;INS-IGF2 COL1A2 ZNF496 ZNF250 UCMA ZNF45 HEY1 HEY2 ZNF41 CTLA4 ZNF248 ZNF485 ZNF483 ZNF235 SLBP ZNF473 SERPINB13 ZNF470 HTT ZNF226 ZNF222 CR1L;CR1 ATAD2 ZNF77 ZNF79 SKI ZNF70 AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 NFYB RORC RORB NFYC ZNF689 ZNF205 ZNF446 ZNF688 ZNF445 PITX2 ZNF202 ZNF200 ZNF160;ZNF347;ZNF665-1 ZFP69B CTSK FOXP3 NPAS4 ZNF432 PVALB BLK GRIA2 MAX DLX6 FOXO4 FOXO3 CTSV;CTSL ATXN3 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 SOCS4 ZKSCAN1 ZNF662 ZNF660 FBXO32 ZNF419 MMP13 ZNF658 ZNF416 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 FURIN ZKSCAN7;ZNF852 PPM1A HAND2 ITGA5 SPP1 PPM1D YAP1-1 ZNF624 ZNF621 E2F5 E2F6 ZNF747;ZNF764 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 RB1 ZNF613 SMARCB1 STUB1 CCNH EHMT2 PTPN4 EHMT1 TRIM33 UXT LGALS3 CCN2 H2AC14 TRIM28 ZFP1 ZNF713 ZNF711 ZNF710 L3MBTL2 FOXG1 TGFA ZNF707 MED1 ZNF706 SMARCC1 ZNF704 SMARCC2 ZNF703 HIVEP3 WWTR1 YES1 MED4 IQSEC3 MED6 ITGBL1 MED7 MSTN HNF4G FOXO1-1 SATB2 ZFP14 RXRG ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GAD1 GAD2 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CCNG2 PPARGC1B ZFP28 CREBBP IHH ZNF274;ZNF74 ZNF382 CCND3 CCND2 NPPA SETD1B MSX2 SETD1A GEM SMARCA2 GPRIN1 SMAD2;SMAD3 SMARCA4 ZFHX3 AUTS2 IL2 IL3 H2AC20 ZNF30 BMP2 LDB1 H2AB2;H2AB3;H2AB1 MYBL2 EZH2 RBM14 CBX3-1 TGIF2 ELF1 PHF20 ELF2 CAT RETN ASH2L ZNF804B MED16 ZNF175 MED17 SERPINE1 MED12 JUNB MED14 RNF111 MED13 ZSCAN25 MED10 ZNF157 ZNF398 ZNF394 NKX2-5 NR2C2AP ZNF383 ZNF140 CDC7 NR1D2 ACTL6A ZNF699-7 ZNF135 ZNF133 RARG MED27 BTG1 ZNF568-3 SIRT1 UBE2D3-1 MED23 RSPO3 TEAD1 TEAD2 NCOR2 TEAD3 KAT2B ZIK1 H2AJ TEAD4 KAT2A TCF12 PAX5 NCOR1 MED24 TAL1 RARB ZNF599 ZNF114 MED20 ZNF597 ZNF112 OCLN-1 ZIM2 ZNF584 GPS2 ZNF583 PCGF6 MBD3 ZNF582 CDKN2B SUZ12 H2BC5 PCGF5 PCGF2 WWP1 SIRT3 H2BC1 RYBP ZNF669;ZNF670 ZNF334 GTF2H1 ZNF573 GTF2H3 ZNF570 GTF2H4 CSF2 GATAD2B ITGA2B GATAD2A ZFP30 ZNF569 ZNF567 MED31-1 ZNF566 ZFP37 ZNF331 ZNF565 CYCS-1 ZNF563 IGFBP1 EP300 PF4;PF4V1-1 ZNF302;ZNF181 NRBP1 MEN1 ZNF311 ZNF793 ZNF792 H2AC4 ZNF791 KRBA1 ZNF549 ZNF548 TBL1XR1 ZNF317 ZNF546 ZNF354A;ZNF354B-4 ZNF304 ZNF786 KMT2D SKIL PLXNA4 KMT2A ZNF300 KMT2C ZNF782 KMT2B ESRRB ESRRG ZFP69 MED30 CDK6 ZNF777 ABL1 ZNF775 ZNF426-1 ZNF774 ZNF772 ZNF324B;ZNF324 ZNF771 ZNF770 ZNF529 ZNF521 CBX5 CDK8 ZNF75D CDK7 ZNF75A STK11 CDK5 ZFP90 CRH ZNF514 ZNF750 MNAT1 ZNF746 ZNF740 GSK3B KCNIP3 KLF4 RAD51 ZNF606 DPY30 ZNF605 CHD4 SOX9 CHD3 ZNF839 ZNF555;ZNF57;ZNF556 TWIST2 CITED1 SIN3B CITED2 SIN3A CITED4 H2BC21 PARP1 GP1BA ZNF649 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 NPY WDR5 CAMK4 LMO1 ZNF197;ZNF660-ZNF197 TBP LMO2 EED ATP1B4 LIFR KCTD6 H2AZ2;H2AZ1 ZNF124-4 ARID1A COX4I1 NOP2 ARID1B COX4I2 ZNF264;ZNF805-1 SMAD1 SMAD4 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 THRA ARNT SMARCD1 NR2E1 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 OPRM1 SMARCD2 CAMK2B CAMK2D HDAC2 CAMK2A SMARCD3 NR2C2 HDAC3 THBS1 HSPD1 HDAC1 HES1 CAMK2G ZNF189 ZNF286A ZNF184 ZNF180 RBBP4 OPRK1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2L SMARCE1 DEK H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 NDUFA4 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RXRB ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 G6PD YWHAB XPO1 AKT1 YWHAZ MAPK14 MAPK11 GLI3 GLI2 RBX1 ITCH PIP4K2A PIP4K2B PIP4K2C MED8 CCNK CCNT1 GTF2B SUPT16H GTF2F1 GTF2F2 NEDD4L GTF2E1 GTF2E2 PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B RRM2-1 ELL ELOC-1 TAF7L ELOA NELFB ELOB NELFCD NELFA NELFE NCBP1 GTF2A1 GTF2A2 CTDP1 RNMT TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 ESRRA TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GLS2 TXNRD1 FKBP5 PPP2CB;PPP2CA AXIN1 PPP2R5C PPP2R1B RET GATA3 HNF4A JAG1 PRDM1 MYC COX7A2L-1 ARNTL TNRC6C MOV10 ARNT2 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 COX7A2 TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EAF1 EAF2 AKT2 AKT3 SNRPD3 SUPT6H AFF4 POMC SNRPE-2 SFN MLLT1 MLLT3 NLRC4 IWS1 CASP1 TXNIP SKP2 PRMT1 MET TCF7L1 DLX5 SOX2 MYB TSC2 TSC1 STAT1 TJP1 ZFPM1 GATA4 GATA2 GATA1 NFE2 SNRPF SNRPB IRAK1 CAV1 YWHAQ YWHAH PDPK1 SNRPG-2 PTPN11 CALM3;CALM1 PABPN1-1 SOD2 IFNG CCNE2 CCNE1 PLK2 MDC1 ATF2 TP53RK NOC2L SGK1-1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 MAML2 RHNO1 MAML1 E2F4-1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 TFDP1 NUAK1 PCBP4 PRDX1 TFDP2 TP53BP2 ATRIP MAML3 PRELID3A NOTCH2 NOTCH3 BANP BARD1 NOTCH4 PLK3 PRELID1 E2F1 CRADD GADD45A TPX2 RAD17 JUN ATM SNW1 CDK12 MAMLD1 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM BRCA1 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D BRPF3-1 PCNA WRN PLAGL1 PERP PMS2 SOCS3 RICTOR BRD7 PTPN1 TIGAR RPA1 RPA2 CDK4 MLH1 HIPK1 CDK2 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 FANCI BRPF1 CNOT10 FANCC CNOT4 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CNOT1 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA RBL2 RBL1 BIRC5 TMEM219 PRKAA1 TRPC3 RNF34 AURKB TP53INP1 RBBP8 RFFL E2F7 E2F8 ARID3A PML MTOR RAD50 BAX HDAC10 FASLG EPC1 PRDM7;PRDM9 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKCQ PRMT6 PBRM1 ACTL6B BDNF CDK5R1 GCK YEATS4 MAPK1 MAPK3 ARID2 CCNA2-1 CCNA1 KDM5B PRKAB2 HDAC8 SCO2 REST PRKAG2 MED15 MED26 MED25 KIT PPARD PRKCB RAMAC LSM10 LSM11 NABP1-1 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 PHAX ZNF143 G6PC1 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 SP1 RPRD1B RPRD1A SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 PTEN CPSF2-1 NUDT21 RRM2B USP9X PRKAA2 BRIP1 WDR61 APOE PCK1 WDR33 PAPOLA FIP1L1 COX7B COX7C COX8A SREBF1 COX8C CSTF3 CSTF2 SRC SRF COX5B COX5A COX6C CPSF4 CPSF1 CPSF3 COX6A1 COX6A2 COX6B2 COX6B1 SRRT CTR9 RTF1 SYMPK PAF1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR4A2 NR5A1 AR RXRA SUMO1 RARA CARM1 PGR PPARG PPARA CSTF2T TP53 GLS NAMPT GAMT CLP1 CSNK2A2 CGA NR1D1 CSNK2B CPSF7 GPI PCF11 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation FLT3LG PTPN11 STAT5A STAT5B GAB2 FLT3 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME UGT1A1;UGT1A6 GGT5 ABCC5 GGT7 CNDP2 GGT6 GSTP1 ABCC4 GSTT1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GGT1 SULT2A1-4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ABCG2 CYP2E1 NAT1 GSTM1;GSTM2-1 ACY1;ABHD14A-ACY1 ABCC3 ABCC1 ABCC2 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT DHH IHH SHH TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts CPSF1 NCBP1 NUP133 CPSF3 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E SYMPK NUP210 NUP93 FIP1L1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 SLBP RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 CPSF2-1 NUP35 NUP62 NUP37 WDR33 NDC1 CPSF4 SEC13 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B NAGLU TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 TP53 PCBP4 CDKN1A ZNF385A FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) UBN1 H1-0 H1-3 H1-2 H1-5 H1-4 HIRA EP400 HMGA2 CABIN1 TP53 LMNB1 ASF1A RB1 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins VPS37C VPS37D VPS37A VPS37B RPS27A NMT2 UBAP1 UBB;UBC VPS28 TSG101 MVB12B MVB12A UBA52 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 NTHL1 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes BDNF GEM ARNTL CDK5R1 RBFOX3 ARNT2 NPAS4 MDM2-2 RET CDK5 IQSEC3 NAMPT INS;INS-IGF2 SYT10 MAPK1 PLK2 ARNT MAPK3 FOS CREBBP XPO1 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation PPP2R1A PIK3CA MTOR PIK3R3 CD28 PIK3R6 PIK3R5 AKT2 GRAP2 AKT3 PAK1 RAC1 YES1 CD86 CD80 PAK3 LYN CTLA4 AKT1 PAK2 THEM4 RICTOR PRR5 LCK PDPK1 PPP2CB;PPP2CA MLST8 PPP2R5B PPP2R5A PPP2R5D TRIB3 PPP2R5C MAP3K14 CDC42 PIK3CD PPP2R1B MAPKAP1 PIK3CG PPP2R5E PIK3R2 PIK3CB MAP3K8 VAV1 PIK3R1 FYN SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 SECISBP2 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 SARS1 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 SEPSECS RPL18A RPL23A FAU RPL12-1 RPS27A SEPHS2 RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 EEFSEC RPS6 RPL13 RPL18 RPSA RPL17 PSTK RPL19 RPS15 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis GSK3A TRIM27 CTSG SFPQ-1 KPNA1 RPS27A RNF213-2 NOS2 PGK1 HGS ATP6V1H UBB;UBC CORO1A RAB7A RAB5A KPNB1 MAPK1 MAPK3 VPS33B ENO1 DUSP16 UBA52 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB-1 HADHA ACADL ECI1 ACADM DECR1 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation BMP1 LAMA3 TLL2 TLL1 LAMC2 LAMB3 COL7A1 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle GJA1 ARHGEF7 STOM WAS PAK1 IQGAP3 FMNL3 SLC4A7 DOCK8 PAK3 SNAP23 PAK4 GIT2 JUP CAV1 MPP7 ARHGAP1 NIPSNAP2 WASL SYDE1 CDC42 CDC42EP1 ARL13B VAMP3 PIK3R2 PIK3R1 ARHGAP5 CDC42BPB ARHGAP21 CDC42BPA CPNE8 OPHN1 TMPO ARHGAP35 SCRIB WWP2 VANGL1 DEPDC1B OCRL RAB7A ARHGAP26 ARHGAP32 PAK2 DIAPH3 GIT1 TRIO TFRC LAMTOR1 WIPF2 STEAP3 FNBP1L PREX1 RHOJ SLC1A5 FNBP1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 MDM2-2 PSMC3 PSMA1 PSMC4 PSMC1 MDM4 UBA52 PSMD12 PSMD11 CHEK2 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 PSMB4 RPS27A PSMD7 CDKN2A PSMB5 PSMB2 PSMB3 UBB;UBC TP53 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus NUP133 NUP50 POM121;POM121C NUP54 NUP42 NUP43 RAE1 RANBP2 POP5 POP7 POP1 CSTF2 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 TSEN54 RPP38 RPP21 RPP25 NUP35 TSEN34 DDX1 RPP14 C2orf49 CLP1 RTRAF RAN RPP40 XPOT FAM98B NUP37 CPSF4 CPSF1 NUP107 NUP188 NUP210 NUP93 TRNT1 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions PSPN COL6A2 GFRA2 GFRA4 COL4A3 ARTN COL6A1 CNTN2 COL6A3 COL6A6 COL4A5 COL6A5 CACNA1H CACNB2 CACNB3 GFRA1 GDNF ST8SIA2 CACNA1D AGRN CACNA1C COL9A1 ST8SIA4 COL9A3 COL9A2 CACNA1G CACNA1I CACNB1 NCAN NRTN CACNB4 NCAM1 COL4A2 CACNA1S COL4A1 PRNP COL4A4 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 FGF20 FGF23 FGF2 KLB FGF19 PLCG1 FGFR4 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling ATP6V0B INSR ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V1E2 ATP6V1B1 ATP6V1G1 ATP6V1G2 CTSD IDE PTPRF ATP6V1H INS;INS-IGF2 ATP6V1G3 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 ATP6V0A4 ATP6V0E2;ATP6V0E1 ATP6V1D PTPN1 ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 ATP6AP1 TCIRG1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FGF2 KLB FGF19 PLCG1 FGFR4 HRAS PIK3R1 FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSMA6 PSMA3 PSMA4 PSMA7 PSMA1 PSMB6 PSMB7 PSME2 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME1 PSMB10 PSMB8 PSMB9 PSMA2-1 PSMA5 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 FOXP3 RSPO3 AXIN1 ESR1 CBFB TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion TRMT10C PRORP YRDC TRMU OSGEPL1 MTO1 HSD17B10 TRMT61B GTPBP3 TRIT1 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression NOTCH1 NFKB1 MAFK RELA NFE2L2 CREBBP MYC EP300 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage APRT MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle MFN1 MYO19 RHOT1 MFN2 TRAK1 TRAK2 RAP1GDS1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport TGFA CTSC SEC31A TRAPPC3 GOSR2 TRAPPC1 TRAPPC4 TRAPPC5 SAR1B CTSZ TRAPPC9 GOLGA2 TRAPPC2;TRAPPC2B GRIA1 TRAPPC6A NSF TMED2-1 TRAPPC6B RAB1A SEC22B SEC23A RAB1B LMAN1 SEC24B TRAPPC10 STX5 SEC24A YKT6 AREG SEC24C MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C CSNK1D NAPB TMED10 STX17 SCFD1 LMAN2L USO1 NAPG LMAN2 SEC31B ANKRD28 SEC23IP COL7A1 CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 F5 SEC24D-1 F8 NAPA CD59 TFG TRAPPC2L TBC1D20 PREB SEC13 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PPIA PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle PTK6 CDKN1B CCNE1 CDK4 CDK2 CCND1 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase DKC1 PIF1 NHP2 SHQ1 WRAP53 CDK2 ACD TINF2 TERF2 PPP6C POT1 CCNA2-1 CCNA1 TERT TERF2IP PPP6R3 TERF1-1 RUVBL2 RUVBL1 ANKRD28 NOP10 RTEL1 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) TLR5 MYD88 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 CYP17A1 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate SUOX TSTD1 ETHE1 TST SQOR SLC25A10 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PSMD12 PSMD11 WNT5A PSMD14 PSMD13 PSMA7 FZD1 PSMD8 FZD3 FZD2 PSMB6 FZD5 PSMB7 FZD4 PSMD6 FZD7 PSMB4 PSMD7 PARD6A FZD8 PSMB5 SMURF2 PSMB2 SMURF1 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PRICKLE1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 SCRIB PSMC1 VANGL2 UBA52 RPS27A UBB;UBC DVL2 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism GBA ARSD-1 ARSL ARSJ B4GALT6 ARSK ARSH ARSI B4GALT5 ST8SIA5 ARSG ALDH3B2;ALDH3B1 CTSA ACER2 ACER1 CSNK1G2 ACER3 SGPP2 SGPP1 ST3GAL2 ST3GAL3 SPTLC1 SPTLC3 PSAP M6PR GAL3ST1 ORMDL2 ORMDL3 UGT8 HEXB GM2A HEXA ORMDL1 GLB1L3 GLB1L2 SMPD3 B3GALNT1 GLB1L GLB1 SMPD2 SMPD4 SMPD1 ARSB SPHK2 ENPP7 FUT2 FUT1 VAPA SUMF2 VAPB SUMF1 GBA2 SAMD8 A4GALT PLPP3 PLPP2 PLPP1 DEGS1 DEGS2 UGCG SGPL1 OSBP KDSR B3GALT4 GALC GLA SPTSSB B3GNT5 CERS3 CERS4 PRKD3 CERS5 CERS6 PRKD2 PRKD1 CERS1 ST6GALNAC5 CERS2 ST6GALNAC6 ST3GAL5 PPM1L SPNS2 FA2H ABCG2 CERK STS MFSD2B SGMS1 SGMS2 NEU2 SPHK1 NEU3 ASAH1 ASAH2 NEU1 ARSA B4GALNT1 ABCC1 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance RPS14 RPS17 SPTBN2 RPS16 RPS19 CLASP2 RPS18 LIMK2 LIMK1 CSNK2A1;CSNK2A3 RPS11 RPL10A RPS10 RPS13 RPS12 SDC2 CNTN1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 DLG1 RPS23 ERBB2 PLCG1 NRP1 EGFR RPL36AL-1 PRKACA-1 GAB1 MET MYO10 HSP90AA1 RPS27L RPS15A GPC1 RPS3 UBA52 NELL2 RPS2 SLIT3 RPL18A KIF4B;KIF4A ST8SIA2 FAU AGRN RPS27A RPS6KA3 RPS6KA5 CLASP1 RPS6KA2 UBB;UBC RPS6KA1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CNTN6 CHL1 ITGA2 ITGA10 ANK1 UNC5A GRIN2B DCC UNC5B UNC5C UNC5D NTN1 ADAM10 HSP90AB1 RPS4X RPS3A PSEN1 NCSTN CDC42 COL9A1 ST8SIA4 COL9A3 COL9A2 LAMC1 PTPN11 RPL15-1 MMP2 MMP9 PITPNA RPS6KA6 CFL1 PAK2 DLG3 MSN ITGA5 LAMB1 CACNA1H YES1 GRIN1 MYH9 LDB1 RPL10;RPL10L-1 MAPK7 RPLP0 ARHGAP35 RAC1 RPLP2 RPL36-1 RHOA DOK1 DOCK1 ITGA2B PSEN2 APH1A APH1B PLXNA4 ABL1 FLRT3 EIF4A3 RPL22L1 CASC3 ITGAV CDK5 ACTB-1 PSENEN RPL37A-1 GSK3B RBM8A MAGOH;MAGOHB UPF3B RNPS1 PIK3CD TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 RPL13A-1 CXCL12 DOK2 SHC1-1 PRKCQ ITGB3 LYN TIAM1 CDK5R1 RPL23A MAP2K2;MAP2K1 MAPK1 SEMA5A MAPK3 SOS1 GRB10 PIK3R3 MSI1 HOXA2 ISL1 COL4A5 GSPT2 GSPT1 LHX3 LHX2 LHX4 LHX9 USP33 ROBO1 UPF2 ETF1 ZSWIM8 SLIT1 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 WASL PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PSMD3 ANK3 PSMB1 PSMD1 EPHA4 ADRM1 ROCK1 PSMC2-1 PSMA2-1 COL4A2 PSMA5 COL4A1 COL4A4 SEM1 PSMA6 COL6A2 PSMC5 PSMA3 COL4A3 PSMC6 COL6A1 PSMA4 PSMC3 PSMA1 PSMC4 COL6A3 PSMC1 COL6A6 COL6A5 EPHA2 PRKCA RPL12-1 TRIO ITSN1 HSPA8 PABPC1;PABPC3 EIF4G1 MYL6 RBX1 NGEF TREM2 GAB2 TYROBP NUMB RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 PRKACB-1 RPL34 PRKAR2A SDCBP RPL8 ARPC1B ARPC1A RPL9 RPL6 RPL7 RPL35 RPL38 DAG1 RPL39 RPL21 RPL23 RPL22 HRAS FYN RASA1 CACNA1G CACNA1I NRTN RPL24 NCAM1 NRAS CACNA1S RPL27 PRNP PSPN RPL26 GFRA2 RPL29 GFRA4 RPL28 ARTN FARP2 CNTN2 RPL3L RPLP1-2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D PLXND1 ITGA1 SEMA7A SEMA3A ALCAM CRMP1 SCN11A SEMA3E SCN10A RRAS AGAP2 PLXNA2 L1CAM PLXNA3 LYPLA2 SEMA4A DSCAML1 CD72 SHC3 SEMA4D RAP1GAP PTPRC DAB1 FES PTPRA PLXNB3 CNTNAP1 SPTB ITGA9 ELOC-1 NTN4 ABLIM1 RPL11 NEO1 ABLIM2 RPL14 ABLIM3 NFASC ELOB RPL13 EPHB6 RPL18 RPS6KA4 RPL17 CACNB1 EPHB2 RPL19 CACNB4 EPHB1 EPHB4 SCN1B PLXNA1 EPHB3 ABL2 SCN1A SRGAP3 EPHA5 NCBP1 SRGAP2 EPHA7 SRGAP1 EPHA6 ARPC4 EPHA8 ARPC5 ANK2 SHTN1 KCNQ2 KCNQ3 ARPC2 EPHA1 ARPC3 EPHA3 SPTBN4 SPTBN5 PLXNB1 EPHA10 MYL12A SCN3B SCN3A CD24 SCN2A SCN2B NRP2 VLDLR CAP1 CXCR4 NCK2 GFRA3 IRS2 RGMB CACNB2 NCK1 RGMA CACNB3 RELN CAP2 ACTR2 SCN9A NRCAM DSCAM DOK4 DOK5 SCN8A DOK6 EFNA5 EFNA4 EVL TLN1 SPTA1 EFNB2 PFN2-1 EFNB1 SOS2 EFNB3 ROCK2 EFNA1 SRC EFNA3 EFNA2 NCBP2-1 HJV SCN5A GAP43 DCX SCN4A CLTB SCN4B SHANK3 LAMA1 PPP3CB SCN7A PDLIM7 CLTCL1 RPL7A NCAN PFN1 GRB7 RPL35A KALRN MYL12B SPTBN1 CLTC PTK2 CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 SPTAN1 GIT1 CACNA1D VAV3 CACNA1C RHOC VAV2 RHOB SIAH2 SIAH1 ARHGEF7 ITGB1 ROBO2 RET PAK1 PAK3 PAK5 PAK4 MYO9B SLIT2 GFRA1 BUB1B-PAK6;PAK6 VASP ARHGAP39 GDNF ENAH ACTG1 PIK3R2 PIK3CB PIK3R1 CUL2 AKAP5 FRS2 ARHGEF28 PIK3CA CSNK2A2 RANBP9 MYH14 MYH11 EZR MYH10 CSNK2B RPL5-1 RDX DLG4 ACTR3-1 RND1 ARHGEF11 ARHGEF12 SH3KBP1 RPS15 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins RNF2 DNMT3B CBX8 SUMO1 PHC2 PHC1 DNMT3A CBX4 CBX2 PHC3 BMI1 UBE2I RING1 DNMT1 PCGF2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization ADAMTS2 ADAMTS3 P4HB COL4A5 ADAMTS14 SDC4 SDC2 VCAM1 SDC3 ITGB2 COLGALT2 ITGB4 LOXL3 PLOD3 LOXL4 SDC1 PLOD2 PLOD1 LOXL1 LOXL2 COL10A1 COLGALT1 COL27A1 P3H2 P3H1 PCOLCE P3H3 COL2A1 LOX COL4A2 ADAM12 COL4A1 COL4A4 COL6A2 PXDN COL4A3 PDGFA COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 ITGA6 CD47 COL6A6 COL6A5 PPIB PLEC CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 CD151 PCOLCE2 COL11A1 COL11A2 SERPINH1 COL28A1 TTR CRTAP COL24A1 ADAM19 COL22A1 COL3A1 P4HA1 COL5A1 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 PRKCA AGRN ITGAM PDGFB ITGA2 ITGA10 COL16A1 CTRB1;CTRB2 COL12A1 CAPN8 CAPN9 CAPNS1 CAPN6 COL1A1 CDH1 CAPNS2 COL1A2 CAPN7 BSG CAPN5 CAPN2 CAPN3 CAPN1 CAST PHYKPL COL23A1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 F11R PSEN1 DAG1 FN1 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LAMC1 CTSS MMP20 NCAM1 ADAMTS4 ADAMTS5 MMP25 MMP24 ADAMTS1 CTSK CASP3 TIMP2 KLK3;KLK2 KDR CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 CTSB CTSV;CTSL MMP7 COL25A1 MMP1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 CASK MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 ITGAL CD44 TPSAB1;TPSB2;TPSD1 LAMA5 COL15A1 TMPRSS6 ITGA1 ITGA4 LAMA3 FURIN PLG COL19A1 ACAN ITGA5 SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 PRSS3;PRSS2;PRSS1 ITGA9 CAPN12 NTN4 CAPN10 TLL2 TLL1 KLKB1 FMOD LUM TRAPPC4 BMP2 SERPINE1 LAMA1 PECAM1 SPARC DMP1 MUSK DTNA DTNB GDF5 SSPN NCAN DDR1 PTPRS BGN MATN1 MATN4 MATN3 VCAN DDR2 TNXB DRP2 DMD JAM2 JAM3 ACTN1 DSPP TNC COMP EFEMP2 EFEMP1 IBSP TNN TNR UTRN FBN2 FBN3 FBLN1 FBLN2 NID2 FBLN5 BMP7 ITGA11 FBN1 LAMC3 ITGAE HAPLN1 SGCE SGCD SGCA SGCB ITGAX SGCG SNTA1 ITGA2B ITGA3 NRXN1;NRXN3;NRXN2 SH3PXD2A ASPN ITGAD ITGA7 LAMA2 LAMA4 LRP4 LAMB2 SGCZ MFAP5 MFAP4 MFAP3 LTBP4 MFAP2 LTBP2 SNTB1 LTBP3 SNTB2 LTBP1 TGFB2 TGFB3 ITGB1 BMP10 ITGB5 ITGB8 ITGAV ITGB6 FGF2 BMP4 ITGA8 THBS1 TGFB1 VTN ITGB3 FGB ICAM3 FGA ICAM4 ICAM5 FGG ITGB7 ICAM2 ICAM1 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance CCNA2-1 CCNA1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C POLR2D POLR2G SMARCA5 POLR2I DAXX PRIM2 PRIM1 H2AC20 WRAP53 POLA1 POLA2 H2AB2;H2AB3;H2AB1 DNA2 CENPX KNL1 H2AJ HJURP TERT RSF1 MIS18BP1 OIP5 CENPW MIS18A H2BC5 PCNA WRN H2BC1 RPA1 RPA2 CDK2 RPA3 H2AC4 RTEL1 DSCC1 CHTF18 BLM CTC1 STN1 TEN1 CENPN-2 NPM1-2 ACD TINF2 ATRX TERF2 POT1 TERF2IP TERF1-1 POLD1 H2BC21 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 CENPA CENPC CENPS-CORT;CORT;CENPS DKC1 CENPT NHP2 CENPU RBBP4 PPP6C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E LIG1 PPP6R3 CENPH POLR2F POLR2H RBBP7 CENPI POLR2L CENPK RFC1 CENPL CENPM H2BC15;H2BC3;H2BC11;H2BC12 ANKRD28 NOP10 CENPO CENPP CENPQ PIF1 SHQ1 POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 POLD2 FEN1 RUVBL2 RUVBL1 ITGB3BP H2AC14 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade S100A8 TLR2 TBK1 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 ITGB2 SOCS1 RIPK3 APP NFKB2 TLR6 IKBKE CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 ECSIT BIRC2 CHUK BIRC3 BTK OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 DNM1 DNM2 CUL1 DNM3 TANK MAPKAPK2 LBP PPP2CB;PPP2CA CD180 PPP2R5D ATF1 LY86 RPS27A ELK1 ITGAM RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 PLCG2 TRAF2 PELI1 TICAM1 CASP8 LRRC14 USP14 PELI3 RIPK1 PELI2 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB UBE2D3;UBE2D2 NFKBIA FGA FGG UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 PTPN4 TLR1 BPI S100A9 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA DIS3 XRN1 MAPKAPK2 ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A AKT1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 GPCPD1 PIK3R3 PLAAT4 HADHA PIK3R6 PITPNM1 PIK3R5 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 MGLL PLA2G1B AGPAT1 AGPAT2 ALPG;ALPP;ALPI-1 SELENOI AGPAT3 AGPAT4 GPAT4 AWAT2 GPAT3 TPTE;TPTE2 GPAT2 CEPT1 CDIPT PLA2G10;LOC100652777 PLA2G2F BCHE PLA2G2D PIK3R4 PLA2G2E AGK PNPLA8 PIKFYVE MBOAT7 MBOAT1 DDHD2 MTM1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 RAB4A LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 PIP5K1A LPIN1 PIP5K1B LPIN2 SYNJ2 LPIN3 PIP5K1C PNPLA2 SYNJ1 RAB5A MTMR10 MTMR12 MTMR14 PLEKHA1 PIK3C2G PIK3C2A PLEKHA2 PIK3C2B PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 SBF1 SBF2 RAB14 BMX GDPD1 GDPD3 GDPD5 PIP4K2A PIP4K2B PTEN PIP4K2C PIK3C3 PIP4P1 PI4KA PI4KB VAC14 FIG4 RUFY1 MTMR1 MTMR2 MTMR3 MTMR8 MTMR9 MTMR4 MTMR6 MTMR7 PNPLA7 ARF1 PNPLA6 INPPL1 PTPN13 ENPP6 GDE1 SACM1L INPP4A INPP4B TNFAIP8 INPP5F INPP5D INPP5E INPP5J INPP5K TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PI4K2B PIK3CD PIK3CG PIK3R2 LPGAT1 PIK3CB PITPNB CPNE7 CPNE6 PIK3R1 LCLAT1 PLB1 PLA2G2A-1 LIPI LIPH JMJD7-PLA2G4B;PLA2G4B PI4K2A CPNE3 MFSD2A DGAT2 MIGA2 PCYT2 PIK3CA MIGA1 DGAT1 STARD7 CSNK2A2 GPD1L-1 PISD PLA2G15 ABHD3-2 GNPAT PHOSPHO1 GPD2 GPD1 CSNK2B PGP PLBD1 PLA2R1 PLA1A OCRL CDS1 ABHD4 CHAT PLD4 PLA2G3 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT CDS2 SLC44A5 ACHE SLC44A3 HADHB-1 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A PLA2G4D PLA2G4E REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus H1-8 METTL23 HIRA H2BC15;H2BC3;H2BC11;H2BC12 SRPK1 H2BC5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NPM2 H2BC21 H2BC1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function RDH12 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN XRCC6 TBK1 IFI16 PRKDC NLRP4 MRE11 XRCC5 TREX1 DDX41 STING1 IRF3 DTX4 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels KCNJ2 KCNJ12;KCNJ18 KCNJ4 KCNJ14 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC1 APOBEC2 ADAR ADARB1 A1CF TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE TLR3 TICAM1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD ABCA1 APOA1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis F12 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR52A5-2 OR2V2 OR11A1 OR8A1 METAP1 METAP2 OR8I2 OR10G9;OR10G7 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 TAS2R3-1 OR5D18 OR56B1-1 OR10W1 OR8B3;OR8B2-1 OR5B2 OR5D14 AWAT2 OR5D13 EBF1 TAS2R16 OR52M1 SDC4 OR10V1 OR4C12 OR6C3 SDC2 OR5A2 SDC3 OR5A1 OR4C15 OR9I1 TAS2R40 TAS2R41 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 EPB41L1 OR51I1 TAS2R39 RPE65 OR4D11 SDC1 OR4D10 OR2Z1 OR6A2 OR9G4 OR4E1 RDH8 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5B12 OR5AP2 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 ANO2 OR4C3 OR3A2 APOA2 OR3A1 APOA1 OR8K3 APOA4 GUCY2D OR8K1 MYO1C OR4C11-1 HSD17B6 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 TTR OR6F1 BCO2 OR2T2;OR2T35 BCO1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GPC1 OR51M1 OTOP1 OR10X1 APOC3 GPC3 OR8J3-1 OR5C1 GPC2 OR1C1 GPC5 OR2G2-1 OR51D1 GPC4 OR6M1 SDR9C7 APOC2 OR7E24-1 GPC6 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 PRH1-TAS2R14;TAS2R14-3 CAMKMT RGS9BP AGRN OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 GRK1 GRK7 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 KCNMB1 OR2A5 OR51A7 KCNMA1 TAS2R7 OR52J3 RTP2 TAS2R8 RTP1 OR4M1 OR10R2 OR8U3 OR6Q1 OR11H1;OR11H12 OR52I1;OR52I2-1 OR4F21;OR4F16;OR4F29;OR4F3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 OR9G9;OR9G1 OR7C1;OR7C2-9 TAS2R1 TAS2R4 CAPZB OR51G2 OR51G1 OR1F1 OR2H2 OR4L1 OR5B3-13 DHRS3 OR6P1 OR10Q1 OR52E8;OR52E6 OR5M10;OR5M1-1 DHRS9 SAG HSPG2 OR2AP1 RDH10 OR2B11 OR4A47-3 OR51F2 OR5M9 OR51F1 OR2G6 OR4K5 OR4K3 OR5M3 OR4K2 OR4K1 OR10P1 TAS1R2 TAS1R1 TAS1R3 LOC118142757;GUCA1A OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 CAPZA1 CAPZA2 PNLIP ATP2B1 CALM3;CALM1 CASK CHRNA9 GNAL GNGT1 MSN LRP10 LRP12 KCNJ2 LRAT GNG13 MYH9 RBP4 RBP2 GNB1 RBP1 GNB3 LDB1 RETSAT GPIHBP1 CNGA2 CNGA4 CNGB1 RHO VAMP2 GSN LPL TRPM5 TRPM4 LRP1 PRKCQ LRP2 LRP8 STX1A APOB LHX2 GRM1 CACNA2D2 RDH11 SLC17A8 SCNN1G SCNN1D SCNN1B SCNN1A RAB3A PRKCA SYN1 ADCY3 SNAP25 RDH12 GNAT3 FNTA CLPS OPN1SW RLBP1 CALHM1 CALHM3 NMT1 NMT2 PLCB2 APOM APOE SCN1B SCN3A SCN2A SCN2B CACNB2 SCN9A ITPR3 SCN4B HSD17B1 PDE6B PDE6A FNTB;CHURC1-FNTB TWF1 SPTBN1 ABCA4 SPTAN1 CACNA1D OR11H4 OR2M4 OR4C13;OR4C46-2 OR6K3-1 OR1K1 OR4K17 OR1S1;OR1S2 OR4Q3 OR11H6 GNAT1 OR8G1;OR8G5 OR1J4 AKR1B15;AKR1B10 OR11G2 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 RBP3 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR2K2 OR1I1 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR10C1 OR5B17-3 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 PLB1 OR5T1 OR6V1 RIPOR2 OR10G6 CLIC5 OR6C4-1 CIB2 GUCA1C PJVK EPS8 OR10K1-1 OR52W1 PCLO OR5AS1 BSN OR4F5;OR4F17;OR4F4 TPRN PLS1 OR2T6 TMC1 OR13C9 OR2T1 ESPN-1 OR13C8 MYO7A OR2L13 SYP TMC2 OR4X1 OR9A4 MYO3B OR51T1 DNAJC5 PPEF1 MYO3A OR5V1-2 KCNQ4 FSCN2 OR5AR1 OR2V1-1 EZR OR2A2;OR2A14 PCDH15 OR1Q1 USH1C OR12D1;OR12D2-1 CABP2 OR51S1 CABP1 LRRC52 OR7G2;OR7G1-14 ESPNL OR14C36-8 OR5B21 CDH23 STRA6 OR2J1;OR2J2;OR2J3-2 OTOG REEP1 OTOF OR13A1 CHRNA10 OR2T27;OR2T7 XIRP2 OR4N2-1 KCNN2 OR4C16-2 EPS8L2 OR14J1 MPP1 GRXCR1 OR13H1 GRXCR2 CNGA1 WHRN OR2Y1 SLC24A1 RDX OR8D4 OR56B4 LHFPL5 OR8D1 OTOGL TMIE OR6C70 OR6C76 USH1G STRC OR6C75 OR6C74 MYO15A SLC26A5 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR56A4 OR10A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 RDH5 OR8B8 OR2W1 CYP4V2 LDLR OR8B4 OR13F1 OR12D3 OR5AU1 RCVRN OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence E2F2 CDK6 TNRC6C MOV10 MDM2-2 TNRC6A-1 AGO4 ETS2 AGO3;AGO1 TNRC6B ETS1 CDKN2B SP1 MDM4 UBA52 CDKN2D CDKN2C CDK4 ERF ID1 RPS27A CDKN2A UBB;UBC TP53 TFDP1 TFDP2 MAPK1 RB1 MAPK3 E2F1 E2F3 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 PRKCA PPP3CB ROBO2 PRKACB-1 PRKAR2A PRKACA-1 AKAP5 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib CDC37 ERBB2 ERBIN HSP90AA1 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation C1GALT1C1 DPM1 ADAMTS2 DPM2 ADAMTS3 DPM3 EXT1 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A EXT2 MUC15 ADAMTS6 FMOD ADAMTS7 LUM SBSPON CHSY1-1 MUC3A B4GALT7 MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 CTSA THSD4 MOGS ADAMTS10 PRELP ADAMTS15 ADAMTS14 SDC4 MUC1 KERA MUC2 ADAMTS19 B3GAT3 SDC2 ADAMTS17 SDC3 MUC7 MUC4 MUC6 SLC26A2 GALNT3 NOTCH1 MUC17 C1GALT1 MUC5B MUC20 MUC21 ST3GAL3 GALE LFNG B4GALT1 SDC1 NOTCH2 GFPT1 NOTCH3 ALG14 NOTCH4 ALG12 HEXB ALG11 NCAN HEXA BGN MUC13 VCAN GLB1 CSPG5 CHST6 RFT1 GPC1 GPC3 GPC2 GPC5 GPC4 PMM2 MGAT2 GPC6 CHST3 ADAMTS13 AGRN GALK1 GALT DPAGT1 MPI OGN HSPG2 BCAN DOLK SRD5A3 B3GALT6 B4GAT1 DAG1 LARGE1 ADAMTS16 POMGNT1 ADAMTS18 MAN1B1 PGM1 GNE ADAMTS4 ADAMTS5 THBS1 ADAMTS1 ALG8 ADAMTS8 ALG9 ALG6 ADAMTS9 ALG2 CHST14 ALG3 ALG1 MPDU1 DCN DHDDS GALM-2 OMD ACAN NUS1 PAPSS2 NEU1 POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNB1 KPNA1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins ISCU DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot SERPINB2 ANXA2 PLG SERPINE1 SERPINE2 SERPINF2 PLAUR PLAT SERPINB8 PLAU HRG SERPINB6-2 S100A10 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic BICD2 ACTR1A RAB6A GALNT2 PLA2G4A GALNT1 DYNC1LI1 PAFAH1B3 DYNC1LI2 PAFAH1B2 RAB18 RAB3GAP2 RAB3GAP1 RAB6B DYNC1I1 AGPAT3 CAPZA3 ACTR10 CAPZB PLA2G6 PAFAH1B1 DYNC1I2 DCTN2 DCTN6 DCTN5 DCTN3 DCTN4 DCTN1 DYNC1H1 CAPZA1 CAPZA2 BICD1 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake NR1H3 RXRA RXRB MYLIP NR1H2 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs MYCN TNRC6C CDH1 MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B MYC DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS HSPG2 GPC6 EXT1 EXT2 AGRN SDC1 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism ASNS SLC25A12 NAT8L GOT2-1 GOT1-1 SLC25A13 ASPA FOLH1B;FOLH1 GADL1 NAALAD2 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex ISY1;ISY1-RAB43 UVSSA RBX1 COPS4 COPS2 ERCC8 CDK7 POLR2E XAB2 POLR2F POLR2H MNAT1 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 UBA52 POLR2G PPIE ERCC2 ZNF830 POLR2I GTF2H1 DDB1 GTF2H3 ERCC6 GTF2H4 XPA COPS7B AQR COPS7A POLR2J;POLR2J2;POLR2J3 PRPF19 RPS27A TCEA1 CUL4A UBB;UBC COPS3 COPS6 GPS1 COPS5 COPS8 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CUL4B USP7 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway PPP2R1A PTPN3 MARK3 DUSP5 DUSP2 DUSP1 PAQR3 PTPN7 ARAF DUSP4 DUSP6 RAF1 DUSP7 YWHAB PEBP1 DUSP16 DUSP10 PPP5C UBA52 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D RPS27A PPP2R5C PPP2R1B DUSP8 DUSP9 PPP2R5E UBB;UBC MAP2K2;MAP2K1 MAPK1 HRAS BRAF MAPK3 KSR1 MAPK12 BRAP NRAS SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 PIK3CA PTPN11 STAT3 GRAP2 PLCG2 IL34 GAB2 INPPL1 GAB3 INPP5D YES1 THOC5 KRAS SHC1-1 LYN UBA52 CBL CSF1R STAT1 CSF1 SRC RPS27A PIK3CD UBB;UBC HCK PIK3CB PIK3R1 FYN DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle CPS1 ARG1 ASL ASS1 OTC NMRAL1 NAGS SLC25A15 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DPH5 DPH6 DPH7 DNAJC24 DPH1 EEF2 DPH2 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC MUC17 MUC5B MUC20 MUC21 MUC12 MUC15 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC6 GALNT3 MUC13 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity BACH1 MAFK NFE2L2 HM13 HMOX1 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants CTBP2 CTBP1 TCF7L2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACOT8 ELOVL1 SCP2 ELOVL2 ELOVL3 FADS2 ACSL1 HSD17B4 ABCD1 ELOVL5 ACAA1-1 FADS1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System CSNK2A1;CSNK2A3 STX4 SPOP MAF IRF4 STAT6 NFATC2 NFATC1 BATF IL4 PLCG1 PRKACA-1 ACTR1A PPP2R1A NEK2 MIB2 BTRC RBCK1 YWHAG SKP1 TCF7 CDC73 LEO1 FBXW11 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 RPS27A UBB;UBC MAP3K8 DYNC1H1 REV1 MAD2L2 REV3L COLEC12 STAT3 CDH1 CTLA4 CR1L;CR1 CTSS CTSK BLK CTSD LAG3 CTSB PTPRJ CTSV;CTSL CD74 DAPP1 REL PTPN22 SIPA1 RAP1GAP2 NFKBIE FBXO32 ITGAL TRIM63 ITGA4 YAP1-1 E2F5 SMARCB1 STUB1 H2AC14 DPF1 DPF2 DPF3 SMARCC1 SMARCC2 WWTR1 YES1 PAXIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SS18L1 SMARCA2 SMARCA4 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L RNF111 CD36 SS18 NCOA6 ACTL6A UBE2D3-1 ARF1 TEAD1 TEAD2 TEAD3 H2AJ TEAD4 PAX5 SUZ12 H2BC5 WWP1 H2BC1 EP300 H2AC4 KMT2D ERAP2 ERAP1 KMT2A TAP2 KMT2C TAP1 TAPBP ACTB-1 GSK3B DPY30 PAGR1 BCL7A H2BC21 BCL7C THEM4 BCL7B WDR5 EXOSC10 KDM6A TBP C1D EED MPHOSPH6 KCTD6 H2AZ2;H2AZ1 ARID1A ARID1B PIK3CD SMURF2 PIK3CG SMURF1 SMARCD1 CEBPA SMARCD2 SMARCD3 RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 POLR2L SMARCE1 H2BC15;H2BC3;H2BC11;H2BC12 FGB FGA FGG AHCYL1 TLR1 S100A9 S100A8 TLR2 PIK3R3 PIK3R6 PIK3R5 CTSA CD4 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PAG1 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 RAF1 YWHAB AKT1 CD81 DIS3 YWHAZ EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 CR2 EXOSC3 EXOSC2 EXOSC1 RBX1 TREM2 GRAP2 KLRC4-KLRK1;KLRK1 KLRC4;KLRC3;KLRC2;KLRC1 TYROBP KLRD1 LCP2 PRKACB-1 KIF3A ITCH FKBP1A CD3G SYK HRAS FCGR3A;FCGR3B FYN FCGR1A CUL3 NRAS KBTBD7 MYD88 C3-1 NFKBIB CCNK CCNT1 PLCG2 SUPT16H GTF2F1 HMGB1-1 GTF2F2 NEDD4L AP1G1 SUPT4H1-1 AP1S2 AP1S1 AP1S3 AP1B1 SUPT5H CDK9 VAMP8 POLR2J;POLR2J2;POLR2J3 CCNT2-1 PTPRC TAF4B ELL ELOC-1 TAF7L ELOA AP1M2 NELFB MEF2B;BORCS8-MEF2B ELOB NELFCD AP1M1 NELFA NELFE SEC13 CTDP1 TAF9 POLR2A POLR2B POLR2C POLR2D SOCS1 POLR2G TAF9B ITPR1 POLR2I ITPR2 ITPR3 TAF15 PPP3R1 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 TAF6 PPP3CA TAF5 PPP3CB TAF4 TAF3 TAF2 TAF1 CHUK UBA7 HSPA5 UBE2L6 HERC5 IKBKB IKBKG CLTC CLTA LRR1 AP2A1 CCNF AP2B1 KEAP1 AP2A2 CBLB DCAF1 DNM1 HERC4 DNM2 HERC3 DNM3 AP2S1 RNF115 HERC2 SH3GL2 RNF114 HERC1 TRIM21 PPP2CB;PPP2CA FBXO7 FBXO9 PPP2R5B HERC6 PPP2R5A TRAIP-1 PPP2R5D WSB1 PPP2R5C FBXO2 RNF123 PPP2R1B RNF126 HECW2 PPP2R5E ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 LRSAM1 ITGB1 TRIM9 ARIH2 RNF144B GAN PRKN RNF130 INPP5D GPR75-ASB3;ASB3-1 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B ITK HLA-DPB1-1 UBE2Z FBXO21 HLA-DQB2;HLA-DQB1 FBXO22 CD3E CD3D NPEPPS HLA-DPA1 RNF19A MYLIP VASP FYB1 FBXW12 AREL1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FBXW8 ENAH UBE2E3 HLA-DRA FBXO17 LAT UBE4A CD101 FBXO15 SEC61A2 UBE2E2 CD274 MRC2 SEC61A1 LMO7 FBXO10 PIK3R2 SEC61G FBXO11 PIK3CB SEC61B B3GNT3 PSME1 KLHL41 SEC22B KCTD7 PIK3R1 PSMB10 RNF41 PSMB8 KLHL42 PSMB9 UBE2V2 HIF1A CD207 CUL7 CUL5 UBA6 MYC UBA5 CUL2 UBR4 KLHL11 KLHL13 MYCN PIK3CA UBR1 FBXO44 PTPN6 FBXO41 TNRC6C MOV10 FBXO40 BTBD1 TNRC6A-1 AGO4 LONRF1 AGO2 UBE2F UBE2H UBE2B AGO3;AGO1 KLHL25 TNRC6B ZBTB16 GLMN CCND1 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBA1 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 UBE2D1 TRIM69 UNKL RELA ANAPC10 DTX3L PJA2 ANAPC11 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 RNF138-1 CDC27 THOP1 TCF7L2 ANAPC7 RNF213-2 MGRN1 UBE2C ASB13 UBE2E1 ASB14 NFKB1 RNF6 ASB11 UBE2S RNF7 CDC16 ASB12 ANAPC4 ASB17 ANAPC5 RNF4 ANAPC1 RCHY1 ANAPC2 ASB18 FBXL22 ASB15 ICAM2 ASB16 IFI30 FBXL20 ZNRF1 BACH2 ZNRF2 ICAM1 HOXC4 HECTD1 SLAMF6 HECTD2 ASB10 SPTBN2 HECTD3 SH2D1A TRIM41 EAF1 EAF2 RNF25 IL21 FBXL19 TNFRSF13C FBXL18 CTSO FBXL15 AKT2 ACTR1B TRIM74;TRIM73;TRIM50 AKT3 CTSH FBXL16 CTSF FBXL13 CTSE FBXL14 CTSC FBXL12 B2M TRIM39 RELB HLA-DMA ASB8 HLA-DMB ASB9 APEX2 LNX1 ASB6 CD40LG TRIM36 CAPZA3 ACTR10 ASB7 TRIM37 CD84 ASB4 ATG14 LOC102723996;ICOSLG HLA-DOA ASB5 HLA-DOB ASB2 TRIM32 SUPT6H RPN2 SAR1B ZBTB17 ASB1 VCAM1 ITGB2 AFF4 RPN1 TNFSF13B PIK3R4 POLI POLH IRF8 DCTN6 DCTN5 DCTN4 MLLT1 MLLT3 IWS1 NFKB2 RILP MCM3AP SKP2 MAGT1 JAK1 RIPK2 RAP1B MAFK NFE2L2 BTLA TNFRSF14 CANX PPL TCF7L1 MYB STAT1 SEC24D-1 KIF5B KIF5A KIFAP3 KIF4B;KIF4A ATF3 VCP-1 KIF20A PDCD1LG2 MAP3K14 TUSC3 MAP3K7 KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF3B TMEM258 KIF3C KIF18A UBE2V1 KIF11 KIF15 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CAPZB OST4 OSTC STT3A UBE2N KIF23 TAB2 KIF22 STT3B KIF2A BTNL9 BTN3A1;BTN3A3 BTN1A1 PDPK1 IRF1 BTNL2 BTN2A2;BTN2A1 DDOST KIF2C KIF2B DAD1 CDC42 TRAF6 PIK3C3 BECN1 CENPE SEC23A KIF26A CAPZA1 CAPZA2 VHL SEC24B SEC24A PTPN11 SEC24C AICDA CALM3;CALM1 RAB7A PAK2 FBXO4 FBXO6 FBXW4 PSME2 FBXW10;CDRT1 FBXW5 FBXW7 FBXW9 FBXW2 MYH9 FBXL3 FBXL5 PRKAB1 MAPKAP1 SEL1L JUN PRKAG1 RAC1 PRKAG3 RASGRP3 FOS PCNA EPAS1 NFATC3 PMS2 SOCS3 RICTOR STIM1 ORAI2 ORAI1 CDK4 MLH1 MSH2 ITGB5 ITGAV BCL6 PRR5 EXO1 MLST8 RFC5 RFC3 RFC4 RFC2 PRKAA1 RNF34 TRPC1 JUND E2F7 E2F8 MTOR LY96 FOSB CD14 TLR4 CDC34 PRKCQ CARD11 BCL10 RFC1 RASGRP2 RASGRP1 MALT1 LYN CD300LF;CD300LD UBE2D3;UBE2D2 ICAM3 NFKBIA ICAM4 ICAM5 TREM1 PVR SIGLEC10;SIGLEC11;SIGLEC16 ITGB7 LAIR1;LAIR2-1 CD96 PIANP CXADR SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 POLD3 LILRA5-4 OSCAR JAML CD8A POLD2 ULBP1-2 IFITM3;IFITM2;IFITM1 CD300E NCR3LG1-1 CD226 HCST RAP1A CLEC4G COPS5 NCR1-1 CD1D CD1C CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG CD99 KLRG1 NPDC1 SIGLEC5;SIGLEC14 SOS1 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L KLRB1-1 CD160 CRTAM SH2D1B PILRA;PILRB TREML1 SELL TREML4 TREML2 CDC20 SIGLEC1 RAET1E-1 NECTIN2 CD200 CD22 PRKAB2 LGMN PRKAG2 RAPGEF3 RAPGEF4 DERL2 RNF5 OS9 RNF185 PRKCB DYNC1LI1 DYNC1LI2 CD19 CD28 CD86 CD80 TRAT1 PIK3AP1 OSBPL1A LRRC41 PTEN VAMP3 MSH6 E2F2 PDCD1 PRKAA2 NCF1 CD8B;CD8B2 NCF2 NCF4 TRIB3 RAP1GAP WDR61 ICOS SNAP23 TIRAP CD33-1 NCK1 LCK EVL CD79B CD79A TLR6 CSK RBBP6 XDH BLNK BTK ERLIN1 ERLIN2 SH3RF1 CALR-1 S100A1 VAV1 CTNNBL1 WAS CTR9 RTF1 PAK1 SEC31A PAK3 PAF1 DYNC1I1 DERL3 DERL1 DCTN1 PPIA ERLEC1 CYBB CYBA MRC1 CSNK2A2 BRD4 CSNK2B CLEC4M;CD209-2 SH3KBP1 ZAP70 PDIA3 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD LTA4H ALOX5 ALOX15 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases CDK1 TNFAIP3 DDX58 RIPK1 RHOA RNF135 IFIH1 OTUB2 OTUD5 TRIM25 OTUD7A VCPIP1 IKBKG MAVS TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 ESR1 UBA52 OTUB1 UBE2D1 OTUD3 PTEN VCP-1 RPS27A TRAF3 TRAF6 APC UBB;UBC TP53 NOD1 NOD2 RIPK2 TNIP2 OTUD7B INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement COLEC10 C1S C1R FCN2;FCN1 CFD C3-1 MASP1 CFB C2 MBL2-1 C1QC LOC110384692;C4A;C4B_2;C4B COLEC11 C1QB CRP MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction ABCC9 VIM KCNK5 KCNK10 KCNK12 KCNJ14 KCNK13 KCNK15 KCNK16 KCNK18-1 KCNK17 KCNK2 CACNA2D2 KCNK4 KCNK6 KCNK7 KCNK1 AKAP9-1 PRKACA-1 TMOD3 ATP1B2 ATP1B1 KCND1 KCND2 KCNIP1 KCND3 KCNIP2 KCNIP4 FXYD4 FXYD3 GATA4 FXYD1 FXYD6 MYLK RYR1 RYR2 GUCY1A2 GUCY1A1 RYR3 GUCY1B1 CLIC2 TRDN ASPH MYL6 NOS1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 FKBP1B CACNA1G CACNA1I SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 ACTN2 PAK2 MYL4 ANXA2 MYL5 ITGA1 MYL7 MYL1 KCNQ1 SCN11A MYL2 SCN10A MYL3 MYL10 DMPK TPM4 MYLPF TPM3 KCNE1;KCNE1B MYL6B ANXA6 MYBPC3 CES1 MYBPC1 MYBPC2 TNNC1 TBX5 TNNC2 TNNT1 TNNT2 TNNT3 KCNA5 SORBS1 SORBS3 TCAP KCNH2 CACNB1 TMOD1 TMOD4 SCN1B TPM2 TPM1 SCN1A TMOD2 KCNJ2 KCNJ12;KCNJ18 TTN-1 KCNE2 KCNE3 KCNE4 KCNJ4 KCNE5 CALD1 CAV3 NEB FGF14 FGF13 FGF12 WWTR1 CACNA1H FGF11 TRIM72 MYL12A DYSF SCN3B LMOD1 SCN3A MYH3 MYH8 SCN2A MYH6 SCN2B CACNG6 TNNI1 TNNI2 TNNI3 DES RANGRF CACNB2 SCN9A NPPA SCN8A ITPR1 ITPR2 ITPR3 TLN1 SCN5A SCN4A SCN4B SCN7A CACNG7 NKX2-5 DMD KAT2B KCNJ11 MYL12B CACNG8 CACNG4 PXN STIM1 ORAI2 ORAI1 HIPK1 HIPK2 CACNA1C KCNK9 KCNK3 ITGB5 PAK1 KCNIP3 ACTN3 VCL MME NPR1 NPR2 NPPC CORIN CAMK2B TRPC1 CAMK2D CAMK2A CAMK2G MYH11 ANXA1 AHCYL1 ALDH2 PDE5A SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs SOS1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IRS2 SHC2 RALGDS PTPRO ATF2 RALB MAPK13 RIT1 SGK1-1 RIT2 REST SRC SRF JUNB PLCG1 ADORA2A PTPRS GAB1 PPP2R1A MAPK7 MAP2K5 RAC1 TCF12 RHOA PCSK6 YWHAB CRK FOS NTRK1 CLTC CLTA NTRK3 AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 NTF3 AP2S1 MAPKAPK2 DNAL4 SH3GL2 ID1 PPP2CB;PPP2CA EP300 PPP2R5D ATF1 ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MAPK14 MEF2C MAPK11 MAPKAPK3 ADCYAP1 ADCYAP1R1 MEF2D EGR1 STAT3 CDK5 DOCK3 GRIN2B CHD4 SH3GL3 ID4 IRS1 PIK3R2 PIK3CB HRAS PIK3R1 JUND NRAS TPH1 FRS2 PIK3CA PTPN11 BAX KIDINS220 FOSB PCSK5 SHC1-1 NTRK2 TIAM1 BDNF CDK5R1 F3 RALA-1 FURIN NAB1 NAB2 LYL1 ARC VGF TRIB1 SHC3 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 MAP2K2;MAP2K1 RAP1A ID3 RAPGEF1 CDK5R2 ID2-1 MAPK1 BRAF NELFB MAPK3 CRKL MAPK12 FRS3 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery RPS14 HNRNPA1-1 RPS17 RPS16 RPS19 RPS18 EEF1A1 RPS11 RPS10 RPS13 RPS12 RPS27L RPS15A RPS3 RPS2 RPS4X RPS3A FAU RPS25 RPS27A RPS27 RPS29 RPS20 RPS21 RPS24 RPS9 RPS23 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events PLA2G4A CAMK2G ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG PRKCD NBEA PRKCA CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 KPNA2 PRKX MAPK1 CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors ADRA2C ADRA2A ADRA2B HRH1 CHRM3 HTR2B HTR2A DRD1 DRD2 DRD3 ADRA1D DRD4 ADRA1B DRD5 CHRM2 ADRA1A CHRM4 ADRB1 ADRB2 HTR4 HTR6 HTR7 HRH3 HRH2 HRH4 HTR1E TAAR8 GPR143 TAAR9 HTR1F TAAR6 HTR1D HTR1A CHRM1 TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 CHRM5 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate SOX1 ZEB2 ZIC2 POU5F1;POU5F1B OTX2 SOX2 POU3F1 ZNF521 PAX6 NANOG;NANOGP8 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor F8 VWF HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors NUP133 RANGAP1 NUP50 POM121;POM121C NUP54 B2M CD4 NUP42 NUP43 PSMD12 PSMD11 PSMD14 RAE1 PSMD13 LCK RANBP2 RANBP1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 SLC25A5 PSMB2 NUP35 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RAN SLC25A6 ADRM1 NUP37 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 ARF1 PSMA1 PSMC4 PSMC1 SKP1 RAC1 ELMO1 XPO1 UBA52 AP2A1 AP2B1 NUP214 AP2A2 AP2S1 RPS27A UBB;UBC RBX1 CD28 NPM1-2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KPNB1 PSIP1 DOCK2 PPIA HCK FYN CUL5 SLC25A4 NUP107 NUP188 CCNT1 RCC1 BANF1 KPNA1 NUP210 ATP6V1H NUP93 NUP205 AAAS NUP160 PAK2 NUP85 TPR NUP88 AP1G1 AP1S2 CD8B;CD8B2 AP1S1 NUP155 AP1S3 AP1B1 NUP153 CDK9 ELOC-1 PACS1 NUP62 AP1M2 ELOB AP1M1 NDC1 SEC13 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2I DICER1 AGO4 AGO2 AGO3;AGO1 POLR2J;POLR2J2;POLR2J3 POLR2E POLR2F POLR2H POLR2L RAN POLR2A POLR2B POLR2C BCDIN3D TARBP2 POLR2D PRKRA XPO5 DGCR8 DROSHA POLR2G UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins PDCD6IP CALM3;CALM1 MAP2K2;MAP2K1 FURIN MAP2K4 MAP2K7 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response APAF1 UACA AVEN CASP3 DIABLO-1 CASP9 MAPK1 CASP7 MAPK3 CYCS-1 APIP XIAP DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema KLKB1 SERPING1 F12 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription KLF4 FOXA2 STRAP FOXP2 RB1 ZEB2 TFAP2A FOXJ2 ARID1A KLF9 SP1 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR PLA2G4A GNA13 AKT2 AKT3 MGLL TAS2R3-1 S1PR1 PDE3B TAS2R16 DRD1 CCL3L1;CCL3L3;CCL3;CCL18 DRD2 DRD3 DRD4 DRD5 POMC TAS2R40 TAS2R41 APP TAS2R39 ADORA2A EGFR ADORA3 ADORA1 PRKACA-1 PPP2R1A PRKCE TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 WNT3A PRKAR2B PRH1-TAS2R14;TAS2R14-3 RPS6KA3 KPNA2 RPS6KA2 RPS6KA1 TIAM2 PDE1B PDE1A PDE2A PDE11A PDE10A LHB TAS2R7 TAS2R8 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 TAS2R1 TAS2R4 PDPK1 CAMKK1 CAMKK2 C3AR1 TAS1R2 TAS1R1 CDC42 TAS1R3 CALM3;CALM1 MMP3 GNAL GNGT1 NBEA RGS9 ITGA5 RGS6 RGS7 GLP1R SST GNA14 GNG10 RAMP2 GABBR2 GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ IHH GNB2 GNB1 ADM IAPP GNB4 CHRM2 GNB3 CHRM4 ADRB1 ADRB2 GNB5 HTR4 RGS11 HTR6 HTR7 HRH3 HRH2 CALCRL HRH4 HTR1E TAAR8 TAAR9 MCHR1 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 SCT RXFP4 MRGPRD FZD10 RXFP1 MAPK7 RXFP2 RXFP3 CRHBP GPR176 CMKLR1 AGTR2 FPR1 SSTR3 GHRHR GALR3 GALR2 GALR1 NPBWR1 RHOA NPBWR2 WNT10B WNT10A GPR15 FZD9 GPR183 PNOC MC4R GPR18 GPR27 EDNRB GPR25 HBEGF RHO GPR20 PTH1R EDN1 UCN3 EDN3 GPR37 GPR35 GPR32 PTH2R RGR MC3R PLPPR1 PLPPR2 GPR45 PLPPR3 MC1R PLPPR4 MC5R PLPPR5 WNT8A WNT8B NPFFR2 GPR150 NPFFR1 P2RY12 NPFF HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR WNT7B QRFP GPR55 HCRTR2 SCTR HCRTR1 WNT7A ADM2 MTNR1A MTNR1B GPR83 GPR84 CALCB;CALCA RLN3 ECE1 PRLHR INSL3 INSL5 P2RY4 ADCYAP1 APLN ECE2;EEF1AKMT4-ECE2 ADCYAP1R1 VIPR1 VIPR2 RRH PTGDR GPR37L1 KEL TAS2R42 ADRA2B GIPR CRHR1 NLN PENK PPY CDK5 PPP1R1B CRH PDE3A PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB RAMP3 PTH PTGER2 PTGER3 NPW RLN2;RLN1 PRLH MAS1 XK GHRH HCAR1 HCAR2;HCAR3 RAMP1 NPY2R NPY RGS8 CAMK4 PDE8B PDE8A NPY1R PCP2 APLNR SUCNR1 WNT6 GRK3 CALCR GRK6 WNT2 WNT3 PIK3CG OPN3 OXTR PDE4D-1 RGSL1 PTCH2 GRPR OPN5 TRPC7 EDNRA PYY PROK2 GPSM1 PROK1 GPSM2 TRPC6 UTS2R WNT2B PRKCH TRPC3 ADGRE1 TRHR GRM3 OPRM1 UTS2B HEBP1 CAMK2B AGTR1 GRM2 CAMK2D PTGFR ADGRE5 CAMK2A LPAR1 GRM7 LPAR2 GRM6 CXCL12 LPAR3 GPER1 FPR2 ADGRE3 LPAR4 GRM8 CAMK2G NTSR1 PDE4A NTSR2 GPSM3 GPR17 PTGIR NMB NPY5R XCR1 PDE4C OPRK1 XCL1;XCL2 GLP2R NMBR SSTR1 LPAR5 SSTR2 LPAR6 WNT16 NMS SSTR4 NMU SSTR5 GNRH1 RGS14 MLN OPRL1 BRS3 PTHLH GPRC6A CNR2 GPR132 CNR1 CCKAR RGS20 GNRHR S1PR3 PRKCQ FFAR4 RGS22 FFAR2 S1PR2 GAST S1PR5 GPR39 RASGRP2 S1PR4 EDN2 RASGRP1 RGS10 ANXA1 RGS12 TACR2 PDE7B TACR3 ACKR1 TACR1 VIP CCKBR PDE7A NPSR1 GRP F2R TIAM1 PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 DGKG DGKE CHRM1 AHCYL1 DGKD CCR2 GPR68 DGKB GPR65 DGKA PRKX MAPK1 CHRM5 PMCH MAPK3 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ SOS1 LTB4R2 DGKQ DGKK DGKI DGKH PIK3R3 ABHD6 PIK3R6 NTS PIK3R5 MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGS19 RGS13 CALCA RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK KISS1 FFAR3;GPR42 PDE1C GRK2 GIP ROCK1 GCGR PPP1CA PLEKHG5 AKT1 C5AR2 PRKCD PRKCA C5AR1 C5 TRIO CD55 ITSN1 PREX1 PRKCB NGEF GNAS-1 ADCY9 SMO PRKAR1B PRKAR1A ABR ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A ADRA1D PTCH1 ADRA1B ADRA1A TBXA2R GNA12 FSHB ARHGEF33 ARHGEF37 ARHGEF38 CRHR2 SHH CYSLTR1 CYSLTR2 GNAT3 ADORA2B GNAZ HRAS GNAI3 FGD1 FGD2 FGD3 OPN1SW FGD4 NRAS C3-1 SAA2;SAA1 MCF2 MC2R ARRB1 PLCB3 PLCB4 PLCB1 PLCB2 CCR5 WNT9A AGT CHRM3 PLXNB1 AVPR2 RASGRF2 CXCR4 GNAT2 PLEKHG2 PRKCG ITPR1 ITPR2 WNT5A ITPR3 PPP3R1 WNT1 FZD1 SOS2 FZD3 ROCK2 FZD2 SRC FZD5 FZD4 FZD7 PSAP FZD6 FZD8 ARRB2 PPP3CA PPP3CB GNAI1 GNAI2 GCG CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 CCR8 CCR7 BTK CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 KALRN CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 DHH CCL17 CCR10 CCL16 CCR1 NET1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 AKAP13 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 PPP2CB;PPP2CA VAV3 PPP2R5D LHCGR PPP2R1B FSHR GPHA2 RHOC TSHR GPHB5 VAV1 VAV2 RHOB ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 GNAT1 ITGB1 ARHGEF6 PAK1 WNT11 WNT4 WNT9B PDYN FFAR1 PIK3R2 ARHGEF40 PIK3R1 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 PIK3CA CGA ECT2 ARHGEF39 CX3CR1 ARHGEF10L MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 AVPR1B ARHGEF19 ARHGEF18 AVPR1A AVP TSHB CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress DELE1 EIF2AK1 STOML2 PHB2 EIF2S2 EIF2S3;EIF2S3B YME1L1 OMA1 EIF2S1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS CYP19A1 PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis PRPS2 PRPS1 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation RPS6KA3 RPS6KA2 RPS6KA1 RPS6KA6 MAPK1 PDPK1 MAPK3 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling ARHGEF28 ARPC4 ARPC5 LIMK2 ARPC2 LIMK1 ARPC3 PAK1 RAC1 YES1 ACTB-1 RHOA GRIN2B KALRN GRIN1 CFL1 SDC2 LYN ACTR2 PTK2 ARPC1B ARPC1A TIAM1 ACTR3-1 WASL ROCK2 ACTG1 CDC42 ITSN1 HRAS FYN RASA1 ROCK1 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis LPL MED30 PDK4 ABL1 MED1 ACSL1 CDK8 MGLL MED4 CDK5 MED6 MED7 AGPAT2 PAXIP1 PEX11A CCNC-1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PAGR1 PPARGC1B CREBBP H2BC21 CIDEC WDR5 RXRA KDM6A GPAM H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 LPIN1 ASH2L MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 CEBPA NCOA1 NCOA2 ACSS3 NCOA6 ELOVL5 NCOA3 HDAC3 DGAT2 MED27 SIRT1 MED23 NCOR2 RBBP5 H2AJ NR5A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 AJUBA SCD H2BC1 THRSP FABP4 MED31-1 EP300 PHLDA1 H2AC4 ADIPOQ TBL1XR1 RB1 KMT2D KMT2C LIPE H2AC14 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation SRY NR5A1 GATA4 SOX9 PTGDS DHH WT1 FGF9 AMH DMRT1 ZFPM2 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX5 ALOX15 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus RB1 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation ATP5F1A APOO ATP5F1B APOOL MTX2 ATP5F1C SAMM50 ATP5F1D CHCHD3 CHCHD6 ATP5MJ ATP5MG ATP5ME DNAJC11 ATP5MC2 TMEM11 ATP5MC3 MTX1 IMMT ATP5MC1 HSPA9 ATP5PF ATP5PD ATP5PB MICOS13 MICOS10 DMAC2L ATP5PO IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 RIPK3 UBE2D1 UBE2V1 TICAM2 UBE2D3-1 LY96 BIRC2 CHUK TICAM1 BIRC3 RPS27A RIPK1 TRAF6 CD14 UBB;UBC TLR4 IKBKB IKBKG UBE2N UBE2D3;UBE2D2 UBA52 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs NCBP1 SNRPE-2 LSM10 ZNF473 LSM11 SNRPF SNRPB SNRPD3 NCBP2-1 SNRPG-2 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA PSIP1 BANF1 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry MRC1 MERTK TIMD4 UBA7 HSPA5 CD14 CLDN1 CD33-1 GPC1 SDC4 PROS1 UBA3 GPC3 SDC2 GPC2 SDC3 GPC5 UBA1 AP2A1 GPC4 AP2B1 HSPG2 AP2A2 GPC6 CLEC4M;CD209-2 FURIN AP2S1 AGRN SDC1 EMC4 MAPRE3 PIK3R1 ATG7 LY6E RPSA AXL TYRO3 UBA6 UBA5 GAS6 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell DISP2 SCUBE2 ADAM17 NOTUM DHH IHH GPC5 SHH APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B CDK1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 CDC23 CDC20 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) DUXB DPPA4 DPPA2 LEUTX YAP1-1 DUX4;DUXA TEAD4 EP300 TPRX1;RAX2 TP53 ZSCAN4 CREBBP TUT7 TUT4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation LPL MED30 MED13L HELZ2 FAM120B MED1 CDK8 MED4 MED6 MED7 TNF KLF4 CEBPD EBF1 CCNC-1 PPARGC1A TGS1 CREBBP CCND3 SREBF2 RXRA WNT1 CARM1 PPARG PPARA LEP MED16 MED17 NR2F2 MED12 MED14 MED13 MED10 MED8 CD36 MED9 CEBPA NCOA1 NCOA2 MED19 NCOA6 SMARCD3 MED15 NCOA3 HDAC3 MED18 MED11 MED27 MED23 NCOR2 TGFB1 NCOR1 MED26 MED24 CDK19 MED29 WNT10B MED22 MED20 MED25 ANGPTL4 PLIN1 MED21 CEBPB ADIRF SLC2A4 ZNF638 RELA FABP4 ZNF467 CDK4 KLF5 MED31-1 CHD9 EP300 MED28-1 EGR2 NFKB1 ADIPOQ TBL1XR1 PCK1 THRAP3 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism GPT TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSEN2 TGFBR3 APH1A TIMP2 APH1B TIMP1 MMP14 PSEN1 MMP16 PSENEN NCSTN DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP1BA GP5 GP9 VWF GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP3 FABP5 PPP1CA FABP6 PNPLA4 ABHD5 FABP4 FABP7 PNPLA5 PLIN3 MGLL GPD2 PPP1CC FABP12 CAV1 PLIN1 PRKACB-1 FABP9 FABP1 PPP1CB FABP2 LIPE PRKACA-1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CYBB CYBA ITGB5 CD36 ITGAV SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response APAF1 CASP3 DIABLO-1 CASP9 CASP7 CYCS-1 XIAP THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade METAP1 GNAT1 METAP2 FNTB;CHURC1-FNTB GUCY2D PPEF1 CALM3;CALM1 PRKCQ CNGB1 RHO GNB1 CNGA1 SLC24A1 SAG GNGT1 PRKCA CAMKMT RGS9BP NMT1 LOC118142757;GUCA1A NMT2 GRK1 FNTA PDE6B GRK7 PDE6A RCVRN GUCA1C BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling BDNF NTRK2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C HGSNAT RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 XRCC3 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 RTEL1 SEM1 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection B2M CD4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SLC25A5 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 SLC25A6 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 XPO1 UBA52 NUP214 RPS27A UBB;UBC CD28 RBX1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E DOCK2 HCK FYN CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 BANF1 KPNA1 SUPT16H NUP210 LIG1 LIG4 GTF2F1 GTF2F2 ATP6V1H NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 GTF2E2 PAK2 NUP160 NUP85 TPR NUP88 AP1G1 SUPT4H1-1 AP1S2 XRCC6 CD8B;CD8B2 AP1S1 NUP155 AP1S3 XRCC4 FURIN XRCC5 VTA1 AP1B1 NUP153 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 ELOA AP1M2 NELFB ELOB CCNH NELFCD AP1M1 NELFA CCR5 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 LCK RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 ARF1 RAC1 ELMO1 AP2A1 AP2B1 AP2A2 GTF2H1 GTF2H3 GTF2H4 AP2S1 NPM1-2 CDK7 MNAT1 KPNB1 PSIP1 TBP PPIA GTF2H2C;GTF2H2C_2;GTF2H2 CUL5 SLC25A4 POLR2E POLR2F POLR2H POLR2L ERCC3 ERCC2 PACS1 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System GBP2;GBP3;GBP1 S1PR1 SERPINB1 STX4 SPOP DTX4 TTR RAB14 VAPA REV1 MAD2L2 REV3L COLEC12 COLEC11 HSP90B1 TXN PRKDC DERA APEH IL9 IL9R PTGES2 ALOX15 DDX41 IDH1 TBC1D10C HK3 RAB31 PDXK NOS3 TRAPPC1 ALDH3B2;ALDH3B1 RAB27A GDI2 IQGAP1 CYB5R3 RAB10 RAB18 ARF1 RPLP0 ECSIT PGAM1 TNFSF11 VAMP2 DBNL GSN ERAP2 ERAP1 TAP2 TAP1 TAPBP CRCP POLR3GL POLR3A POLR3B POLR3C FABP5 POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K KPNB1 HSPA2 THEM4 EXOSC10 C1D MPHOSPH6 MME PIK3CD PIK3CG FPR2 ANXA1 PTAFR AHCYL1 ARSA STX1A PIK3R3 PIK3R6 PIK3R5 CTSA WASL LAT2 ACAA1-1 AAMP PAG1 C1QB CPB2 CD81 C1R C5AR2 CFI C5AR1 C8B C8A CPN2 C2 CPN1 C5 C8G C6 C7 C9 CD59 CD55 CR2 CFHR1;CFHR2 CFH-3 C1QC PKM ZEB1 PNP-1 SAMHD1 TREM2 GRAP2 KLRC4-KLRK1;KLRK1 KLRC4;KLRC3;KLRC2;KLRC1 TYROBP KLRD1 LCP2 CTSZ ANPEP ATP6AP2 EBI3 IL27 IL6ST CRLF1 IL27RA PLCG2 SP100 CNPY3 SIGIRR IRAK3 MLEC PTPRC ASAH1 MEF2B;BORCS8-MEF2B MAPK12 AOC1 PTPN18 GYG1 AIP ITPR1 DUS2 ITPR2 ITPR3 FAAP24 PSAP LOC105377022;FANCB FAAP100 CENPX FANCM FANCL FANCA FANCE FANCG FANCF GM2A CXCL8 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 PTPN13 CCL4L2;CCL4L1;CCL4 PFKL CXCR1 IMPDH1 CCL5 IMPDH2 CXCR2 CCL19 CCR1 CCL22 CCL20 PPBP CXCL10 ILF3 MAOA MGST1 NDUFC2;NDUFC2-KCTD14 INPP5D GLIPR1 ITK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 MANBA VASP NME2 FYB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ENAH HLA-DRA AMPD3 LAT CD101 SEC61A2 MRC2 SEC61A1 SEC61G SEC61B B3GNT3 PSME1 SEC22B ALDOC PSMB10 PSMB8 ALDOA PSMB9 CD207 DNAJC5 HSPA9 MAN2B1 NAPRT SLC15A4 SLC2A5 ICAM2 IFI30 BACH2 ICAM1 HOXC4 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 ACTR10 CD84 LOC102723996;ICOSLG HLA-DOA HLA-DOB SUPT6H ZBTB17 VCAM1 ITGB2 AFF4 TNFSF13B POLI POMC POLH IRF8 DCTN6 DCTN5 DCTN4 MLLT1 APP MLLT3 NLRC4 MEFV IWS1 RILP NFKB2 PANX1 MCM3AP PYCARD P2RX7 PSTPIP1 AIM2 CASP1 TXNIP NLRP1 SUGT1 ATG12-1 SKP2 ATG5 RAP1B HGF MAFK NFE2L2 BTLA TNFRSF14 HSPA1L HSPA6 EEF1A1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 TCF7L1 SOX2 MYB KIF5B KIF5A KIFAP3 KIF4B;KIF4A ATF3 PDCD1LG2 KIF20A MAP3K14 EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF12A TNFRSF1B KLC1 EDAR LTA TNFRSF25 KLC4 LTB KLC3 TNFRSF11B KLC2 RACGAP1 TNFRSF11A TNFRSF17 KIF3B TNFSF18 TNFSF14 KIF3C CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 KIF18A CD27 TNFSF8 LTBR KIF11 KIF15 IST1 CAPZB JAK2 KIF23 KIF22 RBSN KIF2A BTNL9 BTN3A1;BTN3A3 BTN1A1 IRF1 BTNL2 IRF2 BTN2A2;BTN2A1 IL23R KIF2C IL23A KIF2B DOCK2 HBD;HBB CDC42 SH2B3 CENPE KIF26A CAPZA1 CAPZA2 MGAM CHIT1 EIF2S2 EIF2S3;EIF2S3B EIF2S1 NOS2 ATP6V1H RAB7A PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF RALA-1 SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 MT2A DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 PRDX6 PRKAB1 MAPKAP1 PECAM1 CDK13 CDKN1A PRKAG1 PRKAG3 CASP10 RASGRP3 FOS PCNA NFATC3 PMS2 RICTOR STIM1 P2RX1 ORAI2 ORAI1 MLH1 LAMTOR2 LAMTOR1 LAMTOR3 MRE11 MSH2 NPM1-2 MAP2K6 FCER2 FANCC BCL6 IL21R PIN1 PRR5 EXO1 MLST8 CASP2 COMMD9 RFC5 RFC3 RFC4 COMMD3 APAF1 RFC2 BIRC5 PRKAA1 SOCS6 RNF34 SOCS5 E2F7 E2F8 PML MTOR CAND1 TLR3 PADI2 CD300LF;CD300LD ICAM3 ICAM4 ICAM5 TREM1 PVR SIGLEC10;SIGLEC11;SIGLEC16 ITGB7 LAIR1;LAIR2-1 CD96 PIANP CXADR SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 OSCAR JAML CD8A ULBP1-2 IFITM3;IFITM2;IFITM1 CD300E NCR3LG1-1 CD226 HCST CLEC4G NCR1-1 CD1D CD1C CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG CD99 KLRG1 NPDC1 SIGLEC5;SIGLEC14 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L KLRB1-1 CD160 CRTAM SH2D1B PILRA;PILRB TREML1 SELL TREML4 TREML2 SIGLEC1 RAET1E-1 NECTIN2 CD200 CD22 BRWD1 CST3 SNCA TSPAN14 ROCK1 MUC13 DSP CD47 CKAP4 SIRPA;SIRPB1;SIRPG DSG1 SIRPB1 LBP CYFIP2 CYFIP1 NCKAP1 CD180 LY86 WASF1-1 ITGAM EEA1 WIPF1 TASL WIPF2 IRF5 WIPF3 PRKCB DYNC1LI1 DYNC1LI2 IQGAP2 NCKAP1L JUP ARHGAP9 ARPC1B ARPC1A LRRC41 VAMP3 NCAM1 FLNA SERPINA1 ABI2 ABI1 NCF1 NCF2 NCF4 STK10 RAP1GAP NFASC ABL2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 SNAP23 CAP1 NCK1 ACTR2 LCK EVL SOS2 SRC CSK RBBP6 WASF2 WASF3 BAIAP2 BTK DSN1 PTK2 FAF2 ITGAX SH3RF1 C1QBP STBD1 SPTAN1 VAV3 RHOG RHOF IFI16 VAV1 NLRP4 VAV2 TREX1 ADAR RHOU WAS PAK1 PAK3 DYNC1I1 MYO9B UBE2I RORA PIAS1 RAB9B SUMO1 ACTG1 PPIA ARG1 TP53 CYBB CYBA ARHGAP45 PLA2G2A-1 CENPS-CORT;CORT;CENPS CPNE3 DGAT1 CSNK2A2 NCKIPSD CSNK2B PLD4 DIAPH1 PLD1 PLA2G6 PLD3 PLD2 ACTR3-1 SLC44A2 LPCAT1 ZAP70 MOSPD2 STOM PTK2B LIMK1 CSNK2A1;CSNK2A3 AGPAT2 VIM TNF IL4R IL13 MAF IRF4 CCL3L1;CCL3L3;CCL3;CCL18 STAT6 STAT5A STAT5B POU2F1 NFATC2 NFATC1 BATF IL4 IL5 PLCG1 PRKACA-1 ACTR1A TNFAIP3 PPP2R1A NEK2 MIB2 TNFRSF1A BTRC CEP290 CYLD RBCK1 YWHAG BIRC2 SKP1 BIRC3 TCF7 HSP90AA1 CDC73 OPTN-1 LEO1 FBXW11 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 TANK CSF1 FUCA1 ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K8 MEF2A DYNC1H1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 TUBB4B MAPK8 MAP2K7 TUBB4A;TUBB;TUBB8B;TUBB8 MAPK10 TNIP2 CDK1 BCL2L11 STAT3 BCL2 BCL2L1 CDH1 COL1A2 CAPN1 CTLA4 ADAM10 ADAM17 ADAM8 CR1L;CR1 PSEN1 NCSTN A2M ELANE PLAUR RORC PLAU HRG CTSS SERPINB6-2 MMP25 PAFAH1B2 CTSK CASP3 TIMP2 CTSG BLK TIMP1 PTPN7 IL34 CTSD GAB3 LAG3 CTSB CTSV;CTSL FOXO3 PTPRJ CD74 DAPP1 MMP1 REL MMP2 PTPN22 SIPA1 MMP3 MMP8 RAP1GAP2 MMP9 NFKBIE OTUD5 FBXO32 ITGAL CRP CD44 COLEC10 FCN2;FCN1 LAMA5 TRIM63 ITGA4 TNFRSF18 FURIN YAP1-1 E2F5 PRSS3;PRSS2;PRSS1 IL2RA KLKB1 SMARCB1 STUB1 PTPN4 LGALS3 H2AC14 DPF1 DPF2 DPF3 SMARCC1 SMARCC2 WWTR1 YES1 PAXIP1 FOXO1-1 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP MAPK13 SS18L1 SMARCA2 SMAD2;SMAD3 SMARCA4 IL2 IL3 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 CAT RETN ASH2L JUNB RNF111 CD36 TARBP2 SS18 PRKRA NCOA6 ACTL6A UBE2D3-1 TEAD1 TEAD2 TEAD3 FPR1 H2AJ TEAD4 PAX5 SUZ12 H2BC5 WWP1 H2BC1 CSF2 EP300 H2AC4 GPR84 KMT2D KMT2A KMT2C ABL1 ACTB-1 GSK3B OPRD1 DPY30 PAGR1 BCL7A H2BC21 BCL7C BCL7B WDR5 KDM6A TBP EED LIFR H2AZ2;H2AZ1 KCTD6 ARID1A ARID1B SMURF2 POLR1C SMURF1 POLR1D SMAD7 SMARCD1 CEBPA YBX1 OPRM1 SMARCD2 CAMK2B CAMK2D ADGRE5 CAMK2A SMARCD3 ADGRE3 CAMK2G RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 POLR2L SMARCE1 PROS1 F13A1 H2BC15;H2BC3;H2BC11;H2BC12 CD177 FGB FGA FGG F2 EPPIN;EPPIN-WFDC6 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 LYZ-1 GMFG DEFB1 SERPING1 SLA2 CLU MCEMP1 DEFB109B KNG1 RNF216 BPIFA1 HP;HPR REG3G;REG3A-1 TSLP CCR6 F12 FUCA2 ATP7A PGLYRP1 IL31RA IL18BP CAMP OLR1 CCR2 IFNL2;IFNL3;IFNL1 DEFB131B;DEFB131A EIF2AK2 STX3 DEFB119 YPEL5 DEFA6;DEFA4;DEFA5 CRLF2 DEFB118 SLA DEFB116 TOM1 SLC11A1 ARL8A DEFB114 GBP5-1 RNASE6 NIT2 DEFB110 CIITA TLR1 TRIM68 RNASE3;RNASE2-2 ACP3 BPI SNAP29 S100A9 TRIM62 S100A8 TRIM22;TRIM34;TRIM6-TRIM34 LTF RNASET2 TLR2 TMBIM1 DEFB129 TRIM56 DEFB128 CANT1 DEFB127 DEFB106B;DEFB106A TRIM46 MUC12 TRIM45 DEFB125 IL2RB MUC15 DEFB123 TRIM35 DEFB121 TRIM38 ART1 TRIM31 ITLN2;ITLN1-2 IL36A PDZD11 MUC3A MUC5AC IL36B RNASE7 TRIM29 CHGA TRIM26 DEFB135 DEFB107A;DEFB107B C6orf120 METTL7A-1 CFP S100A7A;S100A7 SLPI DEFB132 CRISPLD2 ATOX1 DEFB130B;DEFB130A TRIM14 TRIM10 DEFB105A;DEFB105B TMEM63A CD4 SYNGR1 BPIFB2 IL36G MUC1 BPIFB1 NBEAL2 MUC2 BPIFB4 IL1F10 BPIFB6 LCN2 IL20 IL25 MUC7 DEFB103A;DEFB103B IL26 DEFB4A;DEFB4B MUC4 IL24 MUC6 FCER1A PSMD12 IL11 MUC17 FCER1G PSMD11 IL15 MUC5B PSMD14 IL19 MUC20 PSMD13 IL16 MUC21 LEF1 RAP2B TAX1BP1 CAB39 DNAJC3-1 PSMA7 C1orf35 PGGT1B PSMD8 MAP3K3 IL31 PSMB6 GCA PSMB7 IL37 PSMD6 OSM PSMB4 IL18R1 PSMD7 SRP14 PSMB5 ENPP4 PSMB2 RAG2 PSMB3 RAG1 PSMD2 IRAG2 PSMD3 ADGRG3 PSMB1 IL36RN PSMD1 GGH IFIT1 ADA2 IFIT3 IL7R IFIT2 ADRM1 MS4A3 TNFAIP6 CHI3L1 PSMC2-1 MS4A2 PSMA2-1 IL1RL2 PSMA5 ATP8A1 TEC SEM1 PTX3 PSMA6 CNTF PSMC5 FRMPD3 PSMA3 MX1-1 PSMC6 TOLLIP PSMA4 ATP6V1E1 AHSG ATP6V1E2 PLEKHO2 PSMC3 ATP6V1G1 GRN PSMA1 ATP6V1G2 IL10RB PSMC4 CLCF1 PSMC1 ATP11B CSF3 CTNNB1 TMEM179B ATP11A RAB3D IL5RA RAB44 LAMP1 LAMP2 IL13RA2 IL13RA1 KCMF1 ILF2 RAF1 RAB37 RAB4B ATP6V0D1 FGL2 ATP6V0D2 YWHAB HSPA1A;HSPA1B RAB24 ATP6V1A CPPED1 IL1RN IFIT5 IL1R2 KRT1 AKT1 TXK STXBP2 NUP214 ATP6V0A2 VAT1 DIS3 LIF PRKCD ATP6V0A4 CSTB SVIP QPCT YWHAZ ATP6V1D COTL1 ATP6V1C1 IL11RA MAPKAPK2 COPB1 ATP6V1F ATP6V0A1 LPO OASL EXOSC7 ATP6V1C2 OAS1 EXOSC6 OAS3 EXOSC5 ATP8B4 CLEC12A EXOSC4 TMEM30A SCAMP1 EXOSC9 SERPINB3;SERPINB4-1 EXOSC8 IL20RA IL20RB EXOSC3 IL22RA2 EXOSC2 IL22RA1 EXOSC1 PIGR HSPA8 TMC6 SERPINB10 MAPK14 SERPINB12 RNASEL MAPK11 CTF1 TCIRG1 FLNB EIF4G1 LRG1 OLFM4 TXLNA FSCN1 PTPRB IL1RAPL1 ATP6V0B PRCP PTPN9 PTPN5 ATP6V1B2 PTPN2 VPS35L ATP6V0C ATP6V1B1 RBX1 IFI35 DHX58 RSAD2 DHX36 SURF4 PRG2 PRG3 ORM2;ORM1 QSOX1 CD53 OSMR CD63 PGRMC1 CREG1 CD68 IL17C ATP6V1G3 MPO OSTF1 CD93 PRKACB-1 MID1 DOK3 KIF3A ISG20 IL7 TARM1 IRF6 IRF9 MVP PDAP1 ATP6V0E2;ATP6V0E1 S100P ITCH CNTFR ABCA13 NHLRC3 UNC13D RNF125 A1BG CRACR2A PRDX4 FKBP1A S100A11 PA2G4 CD3G SERPINA3 TRIM8 TRIM6 TRIM5 SYK TRIM2 TRIM3 FGR HCK HAVCR2 NFAM1 AGA HRAS CARD9 FCGR3A;FCGR3B ERP44 FYN SLCO4C1 FCGR1A GHDC CSF3R CUL3 EPX LGALS9C;LGALS9;LGALS9B ALPK1 CLEC4A NLRX1 NRAS CLEC4D CLEC4E AGER S100A12 BRI3 KBTBD7 N4BP1 HVCN1 CFD USP18;USP41 CLEC7A MYD88 C3-1 NDN CFB CLEC6A NFKBIB SAA2;SAA1 CCNK PTPN20 NUP107 PTPN23 NKIRAS1 NUP188 KCNAB2 NKIRAS2 IKBIP CCNT1 IL3RA IRAK4 EIF4E2 PELI1 PTPN14 TLR9 PDE12 LRRC14 KPNA1 SIGLEC15 SUPT16H PTPRN2 USP14 NUP210 PELI3 STK11IP PELI2 IFNLR1 NLRC5 IL17RE TIFA GTF2F1 IL17RB HMGB1-1 GTF2F2 DNASE1L1 MAP3K1 NUP93 ATAD3A;ATAD3B IL18RAP DPP7 DNAJC13 CRISP3 NUP205 HEBP2 CMTM6 NEDD4L ABCE1 AAAS NUP160 NUP85 TPR NUP88 AP1G1 SUPT4H1-1 FTH1 AP1S2 XRCC6 NUP155 AP1S1 AP1S3 XRCC5 NUP153 AP1B1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 VAMP8 CCNT2-1 RAB5C TAF4B ELL ELOC-1 TAF7L NUP62 ELOA AP1M2 NELFB TXNDC5 ELOB AP1M1 NELFCD NELFA CCR5 FTL-1 NELFE NDC1 SEC13 NUP133 IGF2R NUP50 POM121;POM121C NUP54 CSF2RB CSF2RA CTDP1 TAF9 CISH POLR2A NUP42 IRS2 POLR2B PRL POLR2C PRLR GHR POLR2D SOCS2 SOCS1 NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 TAF15 PPP3R1 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 NUP35 TAF6 PPP3CA TAF5 PPP3CB TAF4 TAF3 TAF2 TAF1 NUP37 HEXB GLB1 GUSB ARSB CHUK UBA7 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 IFI44L HERC5 IFIH1 IKBKB TRIM25 ARIH1 IKBKG ATF6 FKBP5 CLTC CLTA LRR1 AP2A1 CCNF AP2B1 KEAP1 CBLB AP2A2 DNM1 DCAF1 HERC4 DNM2 HERC3 DNM3 AP2S1 RNF115 HERC2 SH3GL2 RNF114 HERC1 TRIM21 PPP2CB;PPP2CA FBXO7 FBXO9 PPP2R5B HERC6 PPP2R5A TRAIP-1 PPP2R5D PPP2R5C WSB1 FBXO2 PPP2R1B RNF123 RNF126 HECW2 PPP2R5E ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 ITGB1 LRSAM1 TRIM9 ARIH2 RNF144B GAN PRKN GATA3 RNF130 GPR75-ASB3;ASB3-1 HUWE1 KLHL2 FGF2 KLHL3 UBE2G1 UBE2G2 KLHL9 PLAC8 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 CD274 UBE2E2 LMO7 IRS1 FBXO10 PIK3R2 FBXO11 PIK3CB KLHL41 KCTD7 PIK3R1 RNF41 IL2RG KLHL42 UBE2V2 HIF1A PTPRZ1 CUL7 CUL5 UBA6 MYC UBA5 CUL2 JAK3 UBR4 KLHL11 MYCN KLHL13 UBR1 PIK3CA FBXO44 PTPN6 FBXO41 TNRC6C MOV10 FBXO40 TNRC6A-1 BTBD1 AGO4 LONRF1 AGO2 UBE2F UBE2H UBE2B AGO3;AGO1 TNRC6B KLHL25 ZBTB16 GLMN TGFB1 CCND1 KLHL21 KLHL22 KRAS BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 UBE2U ALOX5 MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBA1 UBE2K TRIM71 RNF14 KBTBD13 CSF1R UFL1 UBE2Q1 UBE2Q2 TRIM69 UBE2D1 UNKL RELA ANAPC10 DTX3L ANAPC11 PJA2 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 RNF138-1 CDC27 THOP1 TCF7L2 RNF213-2 ANAPC7 MGRN1 UBE2C ASB13 ASB14 UBE2E1 RNF6 NFKB1 ASB11 IL6 UBE2S RNF7 CDC16 ASB12 ASB17 ANAPC4 RNF4 ANAPC5 RCHY1 ANAPC1 ASB18 ANAPC2 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 RPS15 HECTD1 RPS14 HECTD2 ASB10 RPS17 TBK1 HECTD3 TRIM41 RPS16 RNF25 FBXL19 RPS19 FBXL18 FBXL15 RPS18 AKT2 TRIM74;TRIM73;TRIM50 AKT3 FBXL16 FBXL13 FBXL14 RPS11 FBXL12 B2M TRIM39 RPS10 ASB8 RPS13 ASB9 RPS12 LNX1 ASB6 TRIM36 ASB7 TRIM37 ATG14 ASB4 ASB5 ASB2 TRIM32 RPN2 SAR1B ASB1 RPN1 PIK3R4 SFN RIPK3 GSDME RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 MAGT1 IKBKE JAK1 TOMM70 RIPK2 ANO6 TYK2 IL17RC PRKCE PLPP5 IL17RA PLPP4 MYO10 MYO5A SIKE1 MYO1C CANX TLR8 TLR7 RPS27L PPL RNF135 RPS15A RPS3 RPS2 STAT1 STAT2 SEC24D-1 PKP1 STING1 IL17F FAU VCP-1 DSC1 IL17A TUSC3 KPNA2 MAP3K7 GSDMD RPS9 RPS7 CASP9 RPS8 RPS5 RPS6 RPSA GOLGA7-1 TMEM258 MASP1 UBE2V1 NOS1 IFNAR1 TKFC IRAK1 IRAK2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 MAVS OSTC SQSTM1 STT3A UBE2N FLT3 TAB3 TAB2 STT3B TAB1 HSP90AB1 PRKCSH RPS4X FRK PDPK1 RPS3A DDOST C3AR1 IRF3 IL18 DAD1 IL1A TRAF3 IL1B MBL2-1 TRAF6 IRF7 PIK3C3 BECN1 SEC23A NOD1 NOD2 EIF4A2 EIF4A1 VHL SEC24B IFNB1-4 SEC24A PTPN11 SEC24C EIF4E AICDA CALM3;CALM1 CHRNB4 FBXO4 FBXO6 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 FBXW7 SPHK1 FBXW9 FBXW2 LRRC7 TCP1 CCT8 FBXL3 FBXL5 B4GALT1 SEL1L RAB6A JUN MAPK7 CDKN1B RAC1 RHOA ELMO1 ELMO2 CRK DOCK1 EPAS1 CBL SOCS3 PTPN1 CDK4 VNN1 EIF4A3 ITGB5 ITGAV THOC5 TRPM2 TRPC1 JUND TICAM2 LY96 FASLG TRAF2 FOSB TICAM1 CASP8 RIPK1 CD14 FADD TLR4 SHC1-1 CDC34 PRKCQ CARD11 BCL10 RFC1 RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 NFKBIA POLD3 POLD2 MAP2K2;MAP2K1 RAP1A COPS5 RAPGEF1 MAPK1 MAPK3 CRKL SOS1 NPC2 GRB10 IFNGR1 IFNGR2 P4HB APOB CDC20 PRKAB2 EIF3C;EIF3CL EIF1AY;EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B LTA4H LGMN PRKAG2 GSTO1 RAB3A RAPGEF3 RAPGEF4 GSTP1 DERL2 RNF5 OS9 RNF185 NANOG;NANOGP8 ACLY FLT3LG CD19 EGR1 SLC27A2 CD28 GAB2 IL33 CD86 CD80 IP6K2 IL1RL1 TRAT1 PIK3AP1 SDCBP CASP5;CASP4 HPSE OSBPL1A SNAP25 KPNA4-1 PTEN FN1 ALAD PGM2 PGM1 FNTA MSH6 C1S E2F2 PDCD1 PRKAA2 DHX9 BST2 GRB2 IL22 IL6R PPIE CD8B;CD8B2 TALDO1 TRIB3 PTGS2-2 WDR61 ICOS NEU1 IL10RA BST1 RAB5B MCL1 TIRAP GSTA3;GSTA5;GSTA1;GSTA2 CEBPD CD33-1 IL1R1 GAA APRT AGL-1 CD79B CD79A TLR6 TLR5 ORMDL3 XDH FNTB;CHURC1-FNTB CGAS INPPL1 BLNK HGSNAT C4BPA C4BPB LOC110384692;C4A;C4B_2;C4B GBP6 ERLIN1 ERLIN2 TLR10 CALR-1 PIM1 KPNA7 KPNA5 KPNA3 S100A1 CTNNBL1 DEGS1 PPM1B CA1 CTR9 RTF1 PCBP2 SEC31A PAF1 DERL3 DERL1 ZBP1 VCL LRRFIP1 DYNLT1 GALNS DCTN1 GLA CDA GBP7;GBP4 ERLEC1 ARMC8 MTAP BIN2 GNS MRC1 HMOX1 BRD4 DDX3X-1 HMOX2 CLEC5A VTN TCN1 EIF4G3 EIF4G2 PYGB EIF4E3 GPI PYGL UNC93B1 CLEC4M;CD209-2 PTPN12 SH3KBP1 PDIA3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol NR1H4 CYP8B1 RXRA AMACR CYP7A1 SLC27A2 SLC27A5 BAAT ABCB11 ABCD3 HSD17B4 ACOX2 ACOT8 CYP27A1 AKR1D1 NCOA1 NCOA2 HSD3B7 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint TPTEP2-CSNK1E;CSNK1E RBX1 GSK3B CSNK1A1 PSMD12 CHEK2 PSMD11 CHEK1 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PLK3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 FBXW11 NEK11 UBA52 CUL1 RPS27A UBB;UBC MAPK14 MAPK11 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID IKBKB IKBKG CHUK KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1-1 ACAT1 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes ADAMTS2 ADAMTS3 P4HB COL4A5 COL16A1 COL12A1 COL1A1 COL1A2 ADAMTS14 COL23A1 COL17A1 COL13A1 COLGALT2 PLOD3 PLOD2 PLOD1 COL10A1 BMP1 COLGALT1 COL9A1 COL27A1 COL9A3 P3H2 COL9A2 COL18A1 P3H1 COL14A1 PCOLCE P3H3 COL2A1 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 COL6A6 COL6A5 PPIB COL25A1 PCOLCE2 COL11A1 COL11A2 SERPINH1 COL28A1 CRTAP COL24A1 COL22A1 COL3A1 P4HA1 COL5A1 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 COL15A1 COL19A1 COL26A1 TLL2 TLL1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins LTA4H ALOX5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER RBX1 CDK7 MNAT1 PIAS3 UBE2I PARP2 USP45 DDB2 UBE2N RAD23A ERCC3 CHD1L UBA52 PARP1 ERCC5;BIVM-ERCC5 RAD23B PIAS1 ERCC2 GTF2H1 DDB1 GTF2H3 GTF2H4 RPA1 XPA SUMO1 RPA2 SUMO3 SUMO2 XPC RPA3 RPS27A CUL4A UBB;UBC RNF111 ERCC4 ERCC1 CETN2 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CUL4B TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway SPATA2 TNFAIP3 SHARPIN USP21 USP4 RACK1 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 CHUK BIRC3 OPTN-1 RIPK1 TNF IKBKB IKBKG TAB3 TAB2 TRAF1 TAB1 MAP3K7 RNF31 XIAP USP2 OTUD7B GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CAMK2G MDM2-2 GRIA2 MYO6 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 PRKCG DLG4 PRKCA GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 CAMK2B CAMK2D CAMK2A PRKCB AKAP5 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV DLD BCKDHA DBT BCKDHB GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation SLC32A1 RAB3A SLC6A13 SYT1 ABAT SLC6A1 VAMP2 STX1A CPLX1 ALDH5A1 SNAP25 RIMS1 DNAJC5 SLC6A12 SLC6A11 HSPA8 GAD1 GAD2 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport MB NGB CYGB DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 RPA3 POLD2 FEN1 POLD1 PCNA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling UBE2V1 RELB UBE2N TAB3 TAB2 PSMD12 TAB1 PSMD11 ITPR1 PSMD14 ITPR2 PSMD13 ITPR3 PPP3R1 PSMA7 PDPK1 NFKB2 PSMD8 PYCARD PSMB6 PSMB7 PSMD6 PSMB4 NFATC2 PSMD7 IL1B NFATC1 TRAF6 PSMB5 SYK PSMB2 PSMB3 PPP3CA PSMD2 PPP3CB PSMD3 PSMB1 PSMD1 CARD9 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CLEC7A PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 PLCG2 CHUK CASP8 FBXW11 CALM3;CALM1 CDC34 IKBKB CARD11 BCL10 IKBKG UBA3 MALT1 UBE2D3;UBE2D2 UBA52 NFKBIA NFATC3 PRKCD CUL1 UBE2D1 RELA RPS27A MAP3K14 AHCYL1 UBB;UBC NFKB1 MAP3K7 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing PRKG2 LYPLA1-1 ARL2 FNTB;CHURC1-FNTB USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ZDHHC9 ABHD17B ABHD17A RCE1 BCL2L1 KRAS CALM3;CALM1 PRKCQ ICMT HRAS FNTA PDE6D GOLGA7-1 NRAS ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle BCR ITGB1 PIK3R3 PAK1 DOCK4 PGRMC2 DOCK3 SAMM50 ABR NCKAP1L PAK4 GIT2 MCAM MTX1 CAV1 MPP7 ESYT1 ARHGAP1 DSG2 EMD ARHGAP39 DOCK2 CDC42EP4 SYDE1 CDC42 ARHGAP42 IQGAP1 CDC42EP1 ARHGDIA VAMP3 PIK3R2 NHS SLITRK5 CYBB CYBA PIK3R1 WASF2 LMAN1 ARHGAP21 LBR PIK3CA ARHGAP17 BAIAP2L1 OPHN1 TMPO ARHGAP35 MCF2 LEMD3 DEF6 VANGL1 ABI2 DEPDC1B GARRE1 TAOK3 RAB7A ARHGAP26 ABI1 DOCK1 EPHA2 ARHGAP32 VAPB PLD2 PAK2 DIAPH3 TIAM1 NCF1 NCF2 DOCK10 NCF4 STBD1 CYFIP1 GIT1 NCKAP1 ANKLE2 VAV3 SWAP70 VRK2 TRIO TFRC ARMCX3 LAMTOR1 ERBIN VAV1 VAV2 PREX1 RACGAP1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 ARNTL RBFOX3 TNRC6C ARNT2 NPAS4 MOV10 MDM2-2 TNRC6A-1 RET AGO4 AGO2 AGO3;AGO1 TNRC6B CDK5 IQSEC3 KCNIP3 INS;INS-IGF2 PLK2 FOS CREBBP XPO1 NR3C1 BDNF GEM CDK5R1 REST SRF NAMPT SYT10 MAPK1 MAPK3 ARNT TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJB2 GJA1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules PODXL2 TPST2 BPNT2-1 SULT6B1 SULT4A1 SULT1C2 TPST1 SULT2A1-4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT1B1-1 ABHD14B BPNT1 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions RPS14 GJA1 RPS17 NUP133 TLR2 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 NUP50 AKT2 POM121;POM121C AKT3 SNRPD3 NUP54 RPS11 B2M RPS10 VPS39 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ATG14 NUP42 SAR1B CREBBP PIK3R4 NUP43 VPS11 SNRPE-2 SFN RAE1 RANBP2 VPS16 RPS25 RPS27 RPS29 RPS20 NUP35 RPS21 RPS24 RPS23 YWHAE IKBKE JAK1 TOMM70 NUP37 RIPK2 SFTPD TYK2 IL17RC YWHAG IL17RA CHUK HSP90AA1 SIKE1 SMN2;SMN1 DDX58 TLR8 ISG15 TLR7 RPS27L IFIH1 RNF135 IKBKB RPS15A TRIM25 YWHAB IKBKG RPS3 AKT1 RPS2 NUP214 STAT1 STAT2 YWHAZ SEC24D-1 MPP5 TJP1 NLRP12 STING1 IL17F FAU RPS27A CRB3 IL17A GEMIN2 KPNA2 MAP3K7 RPS9 RPS7 RPS8 RPS5 VPS33A RPS6 VPS33B RPSA TUFM GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 IFNAR1 SNRPB TKFC IRAK1 IRAK2 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UVRAG CAV1 MAVS UBE2N TAB3 TAB2 TAB1 HSP90AB1 RPS4X YWHAQ YWHAH PDPK1 RPS3A LARP1-1 IRF3 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 BECN1 SEC23A DDX20 NOD1 NOD2 SNRPG-2 CNBP-1 SEC24B IFNB1-4 SEC24A PTPN11 PTPN6 VPS41 NUP107 NUP188 VPS45 SEC24C NUP210 NUP93 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NUP62 PATJ TLR1 NDC1 RPS15 SEC13 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation KARS1 PPA2 RARS2 AARS2 PARS2 MARS2 DARS2 HARS2 YARS2 FARS2 WARS2 GARS1 LARS2 SARS2 NARS2 TARS2 IARS2 VARS2 CARS2 QARS1 EARS2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT2 DAG1 POMT1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation NFU1 LIPT1 LIAS NDUFAB1 DBT DLAT DLST FDX1 GCSH-3 LIPT2 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2A ADRA2B DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis RICTOR PRR5 MTOR DAXX NFKBIB MLST8 RPTOR RIPK1 MAPKAP1 PIK3C3 RETREG1 TAOK1 BECN1 ATG14 PIK3R4 NFKBIA DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis GP1BA FGG ANO6 TPST2 F2 TPST1 F5 F8 ADAMTS13 VWF F9 F10 F11 GP5 GP9 PROC GGCX PROS1 FGB FGA GP1BB TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 CDK1 HDAC1 RBBP4 MYBL2 CCNA2-1 E2F4-1 E2F5 TFDP1 RBL2 TFDP2 RBL1 LIN54 LIN37 LIN9 LIN52 E2F1 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR1A HTR1B HTR2B HTR2A HTR5A HTR4 HTR6 HTR7 HTR1E HTR1F HTR1D SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer NOTCH1 ADAM17 MIB2 DLL1 JAG2 DLL4 RPS27A NEURL1 UBB;UBC NEURL1B MIB1 JAG1 UBA52 ADAM10 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism C1GALT1C1 DPM1 ADAMTS2 PPP1R3C DPM2 ADAMTS3 DCXR SLC34A2 ADAMTSL5 DPM3 MMADHC ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON TPMT MUC3A B4GALT7 MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 CTSA THSD4 MOGS ADAMTS10 PRELP ADAMTS15 ADAMTS14 SDC4 MUC1 KERA MUC2 ADAMTS19 B3GAT3 SDC2 ADAMTS17 SDC3 MUC7 MUC4 MUC6 SLC26A2 GALNT3 POMC NOTCH1 MUC17 C1GALT1 MUC5B MUC20 MUC21 ST3GAL3 LFNG SDC1 GFPT1 SFTPD MUC13 CHST6 MCCC2 BTD PC GGT1 PCCA HLCS MCCC1 MAT1A PCCB ACACA CYP21A2 GPC1 GPC3 BCKDK GPC2 GPC5 UBA52 GPC4 CYP11A1 MGAT2 GPC6 MTRR CHST3 ADAMTS13 GCLC GCLM AGRN RPS27A UBB;UBC BCKDHA BCKDHB CYP2U1 LMBRD1 SLC35D1 PNP-1 RPIA CYP24A1 CD320 GBE1 CYP7B1 G6PC1 G6PC3 OGN HSPG2 TBXAS1 BCAN FDXR CYP1B1 B4GAT1 DAG1 MMUT ADAMTS16 LARGE1 CUBN POMGNT1 ADAMTS18 MAN1B1 PGM1 GNE FDX1 NHLRC1 ADAMTS4 ADAMTS5 HPRT1 ADAMTS1 ALG8 ADAMTS8 ALG9 ALG6 ADAMTS9 ALG2 CHST14 ALG3 ALG1 MC2R DCN IDH1 NAGS ADA DHDDS GALM-2 OMD TALDO1 ACAN IVD OPLAH CYP2R1 DBT NEU1 EXT1 FMO3 EXT2 SFTPB FMOD SFTPC LUM CSF2RB CHSY1-1 CSF2RA NAGLU GYG2 GYG1 KHK GAA APRT CYP4F22 GALE SI AHCY LCT B4GALT1 CYP17A1 NOTCH2 NOTCH3 IDUA ALG14 NOTCH4 HEXB ALG12 NCAN ALG11 HEXA SLC37A4 BGN AMN UGT1A1;UGT1A6 VCAN GLB1 HYAL1 IDS CSPG5 GUSB ARSB HGSNAT RFT1 ASS1 MMACHC ABCA3 PMM2 DLD MTR-1 CYP27A1 ACY1;ABHD14A-ACY1 GALK1 MAOA CYP26B1 CYP27B1 ASL EPM2A CBLIF GALT DPAGT1 MPI CYP19A1 GYS2 GYS1 ACAT1 AUH DOLK SRD5A3 B3GALT6 GALNS CYP11B1;CYP11B2 ECHS1 CPS1 ARG1 OTC ALDOB SLC25A15 THBS1 GNS TCN2 PPM1K PAH MPDU1 NMRAL1 MMAA ABCD4 MMAB NUS1 SGSH PAPSS2 POMT2 SEMA5A SPON2 SEMA5B SPON1 HIBCH THSD7B GSS POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NGF SOS1 RALA-1 MAPKAPK2 SHC3 SHC1-1 MAPK14 HRAS MAPK11 SHC2 MAPK12 MAPKAPK3 RALGDS NTRK1 RALB MAPK13 NRAS CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids ACSM1 GLYATL3 ACSM5 ACSM4 ACSM2A;ACSM2B GLYAT POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins DPM1 DPM2 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L PIGS DPM3 CPM LY6K BST1 PIGU PGAP1 PIGT PSCA PIGO PIGN GPAA1 PIGP PIGZ MSLN PIGW ALPG;ALPP;ALPI-1 PIGV PRSS21 PRND TECTB IZUMO1R RTN4RL2 PIGC PIGB NRN1L RTN4RL1 CD109 PIGA LY6D PIGK PIGM SPACA4 PIGL PIGG LY6H PIGF GPLD1 PIGH NRN1 NTM TEX101 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 LYPD8 ART4 OTOA LY6G6C OPCML NTNG1 FCGR3A;FCGR3B NTNG2 PLAUR NEGR1 CNTN5 LY6E PIGX-1 LSAMP GP2 PLET1 PRSS41 GPIHBP1 XPNPEP2 LYPD6B ALPL CNTN3 MELTF CNTN4 TECTA;TBCEL-TECTA MDGA2 RECK MDGA1 SPRN CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 FOLR2 VNN1 VNN2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A3 SLC6A4 SLC6A13 SLC25A22 SLC6A1 SLC6A19 SLC6A15 SLC22A2 SLC6A14 SLC22A1 SLC6A9 SLC17A6 SLC17A7 SLC6A11 SLC6A7 SLC17A8 SLC6A20 SLC25A18 SLC6A5 SLC6A2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors P2RY6 LPAR4 P2RY2 P2RY1 GPR17 P2RY10 P2RY11 LPAR6 P2RY12 P2RY13 P2RY14 ADORA2B ADORA2A ADORA3 ADORA1 P2RY4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 CASP10 FADD RNF135 IFIH1 IKBKB TRIM25 MAVS IKBKG CHUK CASP8 DDX58 RIPK1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation HDAC6 HES1 ABL1 AR SRC ZNF521 YAP1-1 WWTR1 YES1 CBFB SATB2 COL1A1 MAPK1 RB1 UCMA MAPK3 MAF HEY1 HEY2 GLI3 SP7 HDAC3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 SEC11A SEC11C SSR1 RPL27A RPL10;RPL10L-1 RPS25 RPS27 RPS29 SRP14 RPS20 RPS21 RPS24 SPCS3 RPS23 SPCS2 SPCS1 RPL36AL-1 RPL7A RPLP0 SRPRA SRP19 RPLP2 TRAM1 RPL36-1 RPL35A SRP54 SSR4 SSR2 RPS27L SSR3 SRP9 RPS15A SRP72 SRP68 RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 SEC61A2 SEC61A1 RPL21 SEC61G RPL23 SEC61B RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 SRPRB-1 RPL13 RPL18 RPL17 RPL19 RPS15 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection TRIM28 NUP133 DYNC1LI1 VPS37C DYNC1LI2 VPS37D ITGB1 VPS37A VPS37B NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 DYNC1I1 CEBPD VPS4A H2BC18 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MVB12B MVB12A NUP43 H2BC21 RAE1 RANBP2 DAXX H2AC20 EED EZH2 CHMP1A UBAP1 NUP35 CBX1 EGFR NUP37 VPS36 SNF8 VPS25 HDAC3 PML NUP107 NUP188 RBBP4 NCOR2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 NCOR1 RBBP7 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 GPS2 TSG101 H2BC15;H2BC3;H2BC11;H2BC12 AAAS SUZ12 H2BC5 NUP160 NUP85 H2BC1 NUP214 DYNC1I2 TPR NUP88 NUP155 NUP153 CHMP2B ELK1 CHMP2A H2AC16;H2AC11 H2AC4 NFKB1 NUP62 TBL1XR1 DYNC1H1 HNRNPK NDC1 H2AC14 SEC13 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres ITGB1 BMP10 ITGB5 ITGB8 EFEMP2 EFEMP1 ITGAV ITGB6 TGFB1 VTN FBLN1 FBLN2 FBLN5 ITGB3 BMP7 BMP4 BMP2 MFAP5 ITGA8 MFAP4 MFAP3 LTBP4 MFAP2 LTBP2 LTBP3 LTBP1 TGFB2 TGFB3 GDF5 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation CDK1 ATM PPP2R1A MTOR MDM2-2 AKT2 AKT3 CCNA2-1 CCNA1 AKT1 MDM4 UBA52 SGK1-1 CHEK2 RICTOR PRR5 DAXX PDPK1 CDK2 PPP2CB;PPP2CA MLST8 PHF20 RPS27A PPP2R5C CCNG1 CDKN2A PPP2R1B MAPKAP1 UBB;UBC TP53 PRDM1 RNF34 USP7 RFFL USP2 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism PNP-1 GDA NT5C NT5E DNPH1 NT5C1A NT5C1B;NT5C1B-RDH14 NT5C2 ITPA XDH NUDT16 ADPRM NUDT15 NUDT5 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades FGF20 SOS1 SPTBN2 FGF23 MARK3 IL2RB PPP1CC RGL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 RAG2 PSMD2 RAG1 DLG1 EGF PSMD3 IL5 ERBB2 PSMB1 PSMD1 EGFR JAK1 PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PPP1CB PSMA5 RAP1B PRKACA-1 HGF SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A TYK2 PSMA3 MET DNAJB1 PSMC6 PSMA4 PTPN3 AREG PSMC3 PSMA1 PSMC4 PSMC1 IL5RA FGF7 FGF22 FGF3 FGF10 RAF1 ICMT YWHAB HSPB1 XPO1 KIT UBA52 ZDHHC9 VWF RPS27A UBB;UBC GOLGA7-1 CDK1 FLT3LG PDGFB RBX1 BCL2L1 KLB GRIN2B PDGFRB FGF19 FGFR4 PRKACB-1 JAK2 FLT3 LYPLA1-1 FN1 CDC42EP5 CDC42EP3 CDC42 DUSP8 CDC42EP2 DUSP9 SPRED3 SPRED2 RASA4;RASA4B SPRED1 SYNGAP1 HRAS FNTA RASA3 RASA1 FYN RASA2 CUL3 RASAL1 NRTN RASAL2 RASAL3 NCAM1 NRAS DAB2IP PSPN NF1 GFRA2 KBTBD7 GFRA4 ARTN PTPN11 DUSP5 DUSP2 DUSP1 PAQR3 IL3RA PTPN7 FOXO3 CALM3;CALM1 ACTN2 CNKSR2 CNKSR1 PEBP1 GRIN2D IL6R EPGN PAK2 ARRB1 DLG2 DLG3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RASGRF1 ABHD17C ABHD17B ABHD17A RCE1 SHC3 PTPRA NEFL SPTB LRRC7 IL2RA MAPK12 APBB1IP ARL2 TGFA SPTBN4 CSF2RB SPTBN5 CSF2RA MAP3K11 DUSP4 FOXO1-1 RASGRF2 GRIN1 DUSP6 DUSP7 GFRA3 IRS2 SHC2 RALGDS CCND3 TLN1 SPTA1 IL2 IL3 SRC IQGAP1 ARRB2 CSK NCOA3 JUN FNTB;CHURC1-FNTB RAC1 NRG1 NRG2 ARAF EREG BTC KALRN RASGRP3 NRG3 NRG4 SPTBN1 WDR83 RGL3 PDE6D RGL2 HBEGF PEA15 PTK2 IL17RD RAPGEF2 PPP5C SEPTIN7 CDC14A CDC14B RASGEF1A ETV4 CSF2 IGF2BP1 ITGA2B MAPK6 MAPK4 PPP2CB;PPP2CA SPTAN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B LAMTOR2 PPP2R5E LAMTOR3 PHB KSR1 KSR2 MAPKAPK5 RET PAK1 FGF2 PAK3 VCL GFRA1 GDNF IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG CAMK2B MYC BRAP CAMK2D CAMK2A JAK3 FRS2 PIK3CA CAMK2G MRAS TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 RANBP9 TNRC6B ANGPT1 KRAS TEK SHC1-1 PRKCQ ITGB3 RASGRP1 RASGRP4 DUSP16 DUSP10 FGB FGA DLG4 FGG MAP2K2;MAP2K1 IL6 RAP1A MAPK1 BRAF MAPK3 SHOC2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 PPP2R1A PTPN11 LCK PPP2CB;PPP2CA AKT2 AKT3 PPP2R5B PPP2R5A YES1 PPP2R5D CD86 PPP2R5C CD80 PPP2R1B PPP2R5E FYN LYN CTLA4 AKT1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation CTC1 PRIM2 STN1 PRIM1 TEN1 POLA1 ACD POLA2 TINF2 TERF2 POT1 TERF2IP TERF1-1 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON B4GALT6 MUC3A MUC5AC ADAMTS20 B4GALT5 B3GLCT ADAMTS12 CFP THBS2 THSD1 ST6GAL1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 ST3GAL4 MUC17 C1GALT1 MUC5B ST3GAL1 MUC20 ST3GAL2 MUC21 ST3GAL3 MUC13 GALNT11 GALNT14 ADAMTS13 GALNT13 GALNT16 GALNT15 GALNT18 B3GALNT2-2 GALNT10 POFUT2 EMID1 GALNT9;GALNT17 FUT10 FUT11 GALNTL5 GALNTL6 B3GNTL1 GALNT9 GALNT8 POMGNT2 B3GNT9 B3GNT8 MMRN1 B3GNT6 MMRN2 CHST4 GCNT1 GCNT3 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 MGAT5B-1 A4GNT POMK ST6GALNAC2 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 ADAMTS16 LARGE2 POMGNT1 B3GNT7 FKTN ADAMTS18 B3GNT5 B3GNT4 B3GNT3 ST6GALNAC3 B3GNT2 ST6GALNAC4 ADAMTS4 ADAMTS5 THBS1 GALNT2 ADAMTS1 GALNT1 ADAMTS8 ADAMTS9 POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1;POU5F1B SOX2 NANOG;NANOGP8 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS SFTPB INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels KCNJ2 KCNJ12;KCNJ18 ABCC8 KCNJ3 KCNJ4 GNG10 GABBR2 GNG2 KCNJ5 GNG5 KCNJ1 GABBR1 GNG4 KCNJ6 KCNJ8 KCNJ10 GNG8 ABCC9 KCNJ11 KCNJ9 KCNJ15 KCNJ16 KCNJ14 GNG13 GNB2 GNB1 GNB4 GNB3 GNGT1 GNB5 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 NUMB PRKACB-1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ITCH CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GLI1 PSMC2-1 PSMA2-1 PSMA5 PRKACA-1 SEM1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition RPS14 RPS17 RPS16 RPS19 RPS18 EIF5 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EIF4A2 EIF4A1 EIF4E EIF2S2 EIF4B EIF2S3;EIF2S3B EIF2S1 RPS27L RPS15A RPS3 RPS2 FAU RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 EIF4G1 RPSA RPS15 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA EIF4A3 EIF4E PAN2 EIF4B PAN3 PAIP1 CNOT10 CNOT4 TNKS1BP1 CNOT6 CNOT7 CNOT6L CNOT11 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 PARN PABPC1;PABPC3 EIF4G1 EIF4A2 EIF4A1 TUT7 TUT4 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k ALG1 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism ABCC5 HMMR HYAL1 HYAL3 HYAL4 GUSB HYAL2 LYVE1 HAS1 HAS3 HAS2 CHP1 SLC17A5 STAB2 CEMIP HEXB SPAM1 HEXA SLC9A1 CD44 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation HOXC4 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 CTSA ACTR10 CD84 LOC102723996;ICOSLG CD4 HLA-DOA HLA-DOB SUPT6H MAF ZBTB17 VCAM1 IRF4 ITGB2 AFF4 TNFSF13B POLI POLH IRF8 DCTN6 DCTN5 STAT6 DCTN4 MLLT1 MLLT3 IWS1 NFKB2 RILP MCM3AP BATF IL4 ACTR1A MAFK CDC73 LEO1 MYB UBA52 DYNC1I2 DIS3 DCTN2 DCTN3 KIF5B KIF5A EXOSC7 KIFAP3 EXOSC6 KIF4B;KIF4A EXOSC5 EXOSC4 KIF20A EXOSC9 RPS27A EXOSC8 CR2 EXOSC3 EXOSC2 UBB;UBC EXOSC1 REV1 DYNC1H1 KLC1 MAD2L2 REV3L KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 DYNC1LI2 KIF18A STAT3 KIF11 KIF15 CAPZB KIF3A KIF23 KIF22 KIF2A OSBPL1A CR1L;CR1 KIF2C KIF2B CENPE MSH6 KIF26A CAPZA1 CTSS CAPZA2 E2F2 CTSK C3-1 CCNK CCNT1 CTSD CTSB SUPT16H CTSV;CTSL AICDA GTF2F1 GTF2F2 RAB7A ITGAL SUPT4H1-1 ITGA4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 E2F5 TAF4B ELL ELOC-1 WDR61 TAF7L ICOS ELOA NELFB MEF2B;BORCS8-MEF2B SMARCB1 ELOB NELFCD NELFA NELFE DPF1 DPF2 DPF3 SMARCC1 SMARCC2 CTDP1 PAXIP1 TAF9 POLR2A POLR2B MYH9 POLR2C CREBBP POLR2D SS18L1 POLR2G TAF9B POLR2I SMARCA2 SMARCA4 TAF15 TAF12 CD79B TAF13 CD79A TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 ASH2L TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SS18 NCOA6 ACTL6A PAX5 PCNA PMS2 MLH1 CTNNBL1 KMT2D KMT2C MSH2 ITGB1 CTR9 RTF1 ACTB-1 PAF1 DYNC1I1 BCL6 DPY30 PAGR1 BCL7A BCL7C BCL7B HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 EXOSC10 EXO1 KDM6A HLA-DPA1 TBP C1D HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 MPHOSPH6 DCTN1 ARID1A HLA-DRA ARID1B RFC5 RFC3 RFC4 RFC2 SMARCD1 CEBPA SMARCD2 JUND SMARCD3 E2F7 E2F8 RBBP5 FOSB POLR2E POLR2F POLR2H POLR2L SMARCE1 RFC1 RELA POLD3 POLD2 NFKB1 ICAM2 IFI30 BACH2 ICAM1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOT8 ACOX3 CRAT AMACR ACOXL CROT HSD17B4 ACOX2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions DLG3 DLG4 DLG1 NRP2 CNTN2 ANK1 NRCAM RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade FGF20 SOS1 SPTBN2 FGF23 MARK3 IL2RB PPP1CC RGL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 DLG1 EGF PSMD3 IL5 ERBB2 PSMB1 PSMD1 EGFR JAK1 PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PPP1CB PSMA5 RAP1B HGF SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A PSMA3 MET PSMC6 PSMA4 PTPN3 AREG PSMC3 PSMA1 PSMC4 PSMC1 IL5RA FGF7 FGF22 FGF3 FGF10 RAF1 ICMT YWHAB KIT UBA52 ZDHHC9 VWF RPS27A UBB;UBC GOLGA7-1 FLT3LG PDGFB RBX1 BCL2L1 KLB GRIN2B PDGFRB FGF19 FGFR4 JAK2 FLT3 LYPLA1-1 FN1 DUSP8 DUSP9 SPRED3 SPRED2 RASA4;RASA4B SPRED1 SYNGAP1 HRAS FNTA RASA3 RASA1 FYN RASA2 CUL3 RASAL1 NRTN RASAL2 RASAL3 NCAM1 NRAS DAB2IP PSPN NF1 GFRA2 KBTBD7 GFRA4 ARTN DUSP5 DUSP2 DUSP1 PAQR3 IL3RA PTPN7 CALM3;CALM1 ACTN2 CNKSR2 CNKSR1 PEBP1 GRIN2D EPGN ARRB1 DLG2 DLG3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RASGRF1 ABHD17C ABHD17B ABHD17A RCE1 SHC3 PTPRA NEFL SPTB LRRC7 IL2RA MAPK12 APBB1IP ARL2 TGFA SPTBN4 CSF2RB SPTBN5 CSF2RA MAP3K11 DUSP4 RASGRF2 GRIN1 DUSP6 DUSP7 GFRA3 IRS2 SHC2 RALGDS TLN1 SPTA1 IL2 IL3 SRC IQGAP1 ARRB2 CSK FNTB;CHURC1-FNTB NRG1 NRG2 ARAF EREG BTC RASGRP3 NRG3 NRG4 SPTBN1 WDR83 RGL3 PDE6D RGL2 HBEGF PEA15 PTK2 IL17RD RAPGEF2 PPP5C RASGEF1A CSF2 ITGA2B PPP2CB;PPP2CA SPTAN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B LAMTOR2 PPP2R5E LAMTOR3 PHB KSR1 KSR2 RET FGF2 VCL GFRA1 GDNF IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG CAMK2B BRAP CAMK2D CAMK2A JAK3 FRS2 PIK3CA CAMK2G MRAS RANBP9 ANGPT1 KRAS TEK SHC1-1 PRKCQ ITGB3 RASGRP1 RASGRP4 DUSP16 DUSP10 FGB FGA DLG4 FGG MAP2K2;MAP2K1 RAP1A MAPK1 BRAF MAPK3 SHOC2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host HBA2;HBA1 HBD;HBB NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A3 SLC6A4 ALDH2 COMT SLC22A2 SLC22A1 BCHE ACHE LRTOMT GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization CDK1 GOLGA2 CCNB2 CCNB1 RAB2A GORASP2 BLZF1 GORASP1 RAB1A MAPK1 RAB1B USO1 PLK1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling PTPN18 TBK1 IL36A IL36B IL36G IL13 IL1F10 PSMD12 IL1R1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 APP PSMA7 NFKB2 PSMD8 MAP3K3 PSMB6 PSMB7 PSMD6 IL37 CASP1 PSMB4 PSMD7 IL18R1 PSMB5 PSMB2 PSMB3 PSMD2 IL4 PSMD3 PSMB1 PSMD1 IL36RN ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 IL1RL2 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 TOLLIP PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 PTPN13 IKBKB IKBKG IL1RN IL1R2 UBA52 CUL1 RPS27A UBB;UBC MAP3K7 MAP3K8 GSDMD MAP2K4 MAPK8 TNIP2 IL1RAPL1 PTPN9 PTPN5 PTPN2 UBE2V1 RBX1 STAT3 MAP2K6 IL33 IRAK1 IRAK2 IL1RL1 SQSTM1 UBE2N TAB3 TAB2 TAB1 IL18 IL1A IL1B TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 PTPN11 PTPN6 NFKBIB PTPN20 SAA2;SAA1 PTPN23 NKIRAS1 NKIRAS2 CTSG IKBIP IRAK4 PTPN7 TRAF2 PELI1 PTPN14 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 TIFA HMGB1-1 IL18RAP SIGIRR ALOX5 IRAK3 NFKBIA PTPN12 RELA IL18BP NFKB1 MAP2K2;MAP2K1 PTPN4 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors PIAS1 TP53BP1 SP3 MTA1 MDM2-2 SUMO1 SUMO3 FOXL2 SUMO2 CDKN2A TP53 PIAS4 PIAS3 UBE2I TFAP2C MITF HIC1 TFAP2E;TFAP2B ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia ARG1 DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC TCN2 CD320 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 CSNK2A1;CSNK2A3 NUMA1 TUBG2 PPP1CC NME7 BUB3 TUBGCP2 MAD2L1 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 SPDL1 NUP43 RANBP2 C1orf112 NSL1 RPS27 YWHAE CEP57 CETN2 NUP37 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG KNL1 ZW10 CDK5RAP2 HSP90AA1 CEP135 CDCA5 PDS5B PDS5A WAPL HAUS4 HAUS3 CSNK1D DSN1 HAUS6 HAUS5 TUBG1 EML4 CKAP5 RCC2 HAUS2 TUBA4A ZWINT HAUS1 XPO1 CEP63 AHCTF1 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 CCNB1 HAUS8 PRKAR2B PPP2CB;PPP2CA HAUS7 CEP70 PPP2R5B CEP72 NDEL1 PPP2R5A CEP192 PPP2R5D PPP2R5C PCNT PPP2R1B CEP76 CLASP1 PPP2R5E CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E DYNC1LI1 CEP41 DYNC1LI2 CEP43 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CENPT NUP107 CSNK2A2 CENPU CENPF CSNK2B CENPH CENPI TAOK1 CENPK CENPL CENPM NEK9 NEK6 NEK7 CENPO NUP160 CENPP NUP85 CENPQ CLIP1 MAD1L1 ITGB3BP SEC13 NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing NGF PCSK6 FURIN PCSK5 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis VCAN CSPG5 PXYLP1 B4GALT7 UXS1 DCN GPC1 SDC4 GPC3 B3GAT3 SDC2 GPC2 B3GAT2 SDC3 GPC5 B3GAT1 GPC4 HSPG2 GPC6 BCAN B3GALT6 AGRN XYLT2 SDC1 XYLT1 FAM20B NCAN BGN C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) MUC12 MUC15 MUC3A MUC5AC RELB MUC1 MUC2 CREBBP MUC7 MUC4 MUC6 PSMD12 MUC17 PSMD11 ITPR1 FCER1G PSMD14 ITPR2 MUC5B PSMD13 MUC20 ITPR3 MUC21 PPP3R1 PSMA7 NFKB2 PSMD8 PYCARD PSMB6 PSMB7 PSMD6 NFATC2 PSMB4 PSMD7 NFATC1 PSMB5 PSMB2 PSMB3 PSMD2 PPP3CA PSMD3 PPP3CB PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKACA-1 MUC13 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 RAF1 IKBKB IKBKG UBA52 NFATC3 PRKCD CUL1 EP300 MAP3K14 RPS27A RPS6KA5 UBB;UBC MAP3K7 UBE2V1 PAK1 PAK3 PRKACB-1 UBE2N TAB3 TAB2 TAB1 PDPK1 IL1B TRAF6 SYK HRAS CARD9 FYN CLEC4A CLEC4D NRAS CLEC4E CLEC7A CLEC6A PLCG2 CASP8 CALM3;CALM1 CDC34 CARD11 BCL10 UBA3 MALT1 LYN UBE2D3;UBE2D2 ICAM3 NFKBIA PAK2 CLEC4M;CD209-2 UBE2D1 RELA AHCYL1 NFKB1 ICAM2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 EIF5 RPL37A-1 RPL26L1 RPL4 RPL30 EIF5B RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 ABCE1 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi NOTCH1 ST3GAL4 RAB6A FURIN ST3GAL3 LFNG B4GALT1 ATP2A3 ATP2A2 ATP2A1 TMED2-1 MFNG NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG ST3GAL6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 IL3 LIFR ELF1 CBFB UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes PRSS3;PRSS2;PRSS1 TCN1 CBLIF ABCD4 LMBRD1 AMN CTRB1;CTRB2 CUBN DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB-1 MECR HADHA HADH ACADM ECHS1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors PROC F2 F7 GGCX F9 PROS1 F10 GAS6 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts SLC10A1 NR1H4 SLC10A2 RXRA FABP6 SLC27A5 BAAT SLCO1A2 ABCB11 ALB SLC51A SLC51B SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 STARD5 NCOA1 NCOA2 ABCC3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR FGF20 NCBP1 SOS1 FGF23 FLRT2 FLRT3 FLRT1 ANOS1-1 FGF2 KLB FGF19 FGFR4 FGFRL1 POLR2A POLR2B POLR2C POLR2D POLR2G GALNT3 POLR2I NCBP2-1 SPRED2 SPRED1 PLCG1 HRAS PIK3R1 TIAL1 FGF6 PTBP1 MKNK1 RBFOX2 SPRY2 ESRP2 HNRNPH1 NRAS ESRP1 FRS2 HNRNPA1-1 GAB1 TIA1 PPP2R1A PIK3CA HNRNPM PTPN11 POLR2E FGF7 FGFBP1 POLR2F FGFBP3 GTF2F1 POLR2H GTF2F2 FGF22 FGF3 TGFBR3 FGF10 POLR2L GIPC1 UBA52 CBL PPP2CB;PPP2CA HNRNPF POLR2J;POLR2J2;POLR2J3 RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH2 FTO ALKBH5 ALKBH3 ASCC1 ASCC2 ASCC3 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 CD27 TNFRSF1A TNFSF8 TNFRSF14 FASLG TNFSF11 TNFSF13B TNFRSF18 EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF1B EDAR LTA TNFRSF25 TNFRSF11B TNFRSF17 TNFSF18 TNFSF14 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion FARP2 SEMA3A TLN1 RND1 RRAS PLXNA2 PLXNA3 RAC1 FES PIP5K1C NRP1 FYN PLXNA4 PLXNA1 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) SLC6A19 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions ERLIN2 BAG4 FGFR1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB KPNA2 CAMK2G CALM3;CALM1 CAMK4 CAMKK1 CAMK2B CAMKK2 CAMK2D CAMK2A MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition AKT2 AKT3 FBXO5 CCNA2-1 CCNA1 CCND3 CCND2 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 CDKN2D CDKN2C PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 MYBL2 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 E2F1 PSMA2-1 ORC1 CDC7 PSMA5 E2F3 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 PPP2R1A CDC6 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 CDKN2B PCNA AKT1 UBA52 CUL1 RPA1 PTK6 RPA2 CCNB1 CDK4 CDK2 PPP2CB;PPP2CA RPA3 RPS27A PPP2R1B UBB;UBC MCM10 DBF4 CDK1 CDK6 ABL1 CDK7 MNAT1 DHFR2;DHFR DYRK1A CKS1B JAK2 PPP2R3B TYMS RBL2 CABLES1 RBL1 WEE1 MYC HDAC1 E2F2 TOP2A RBBP4 MAX CCND1 POLE LIN54 LIN37 LIN9 LIN52 LYN PPP2R2A;PPP2R2D TK1 CDC45 MCM7 MCM8 MCM3 MCM4 MCM5 E2F5 MCM6 E2F6 CDKN2A MCM2 POLE4 RRM2-1 CCNE2 POLE2 CCNE1 RB1 POLE3 CCNH CDKN1C PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct OSR1 NPNT PAX2 RET BMP4 PAX8 CTNNB1 GATA3 PCDH19 LHX1 ID4 FGF2 HOXB4 WFDC2 PLAC8 MECOM HOXA6 EMX2 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR PDHB PDHX DLD DLAT PDHA1 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing HNRNPA1-1 TIA1 NCBP1 HNRNPM POLR2E POLR2F POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I HNRNPF POLR2J;POLR2J2;POLR2J3 NCBP2-1 TIAL1 PTBP1 RBFOX2 ESRP2 HNRNPH1 ESRP1 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses C1S CGAS CTR9 DDX3X-1 APOA1 RTF1 HSP90AA1 CDC73 LEO1 RBM10 CLEC5A C4BPA PAF1 C4BPB VTN IFIH1 LOC110384692;C4A;C4B_2;C4B TRIM25 EXOC1 MAVS HSP90AB1 STAT2 STING1 CLU MBL2-1 WDR61 IKBKE UBR4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RPS14 NCBP1 RPS17 RPS16 RPS19 RPS18 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPS13 RPS12 UPF2 ETF1 RPL27A RPL10;RPL10L-1 NCBP2-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A PPP2R1A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 PPP2CB;PPP2CA RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 DCP1A EIF4G1 RPSA EIF4A3 CASC3 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 SMG1 RPL8 RBM8A SMG9 SMG7 RPL9 SMG8 RPL6 SMG5 SMG6 RPL7 UPF1 RPS4X MAGOH;MAGOHB RPL35 RPL38 RPS3A UPF3B RNPS1 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 PPP2R2A;PPP2R2D RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors PRKG2 ACO1 COQ3 COQ2 STARD7 PDSS2 PTS HPDL PDSS1 COQ8A NOS3 GCHFR HSP90AA1 SPR CALM3;CALM1 IDH1 DHFR2;DHFR GCH1 COQ9 COQ7 COQ6 AKT1 COQ5 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling FRS2 CBL FGF20 PPP2R1A FGF23 PTPN11 PPP2CB;PPP2CA FGF2 RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 MKNK1 FGF4 SPRY2 FGF16 FGF9 UBA52 FGF18 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping RAMAC NCBP1 CDK7 POLR2E POLR2F POLR2H GTF2F1 MNAT1 RNMT GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 RNGTT SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN GOLGA2 CDK5R1 CDC25A CDC25B BCL2L11 APP SOD2 FASLG FOXO3 CDK5 PRDX2 CAPNS1 CAPNS2 PRDX1 LMNB1 YWHAE CAPN2 CAPN1 CAST CDC25C SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane PIK3R3 PIK3R6 PIK3R5 INPP5D INPP5J INPP5K BMX RUFY1 MTM1 MTMR1 MTMR2 PIP4K2A MTMR3 RAB4A PTEN PIP4K2B PIP4K2C PI4K2B MTMR8 MTMR9 PIP5K1A PIK3CD PIP5K1B PIK3CG SYNJ2 PIP5K1C PIK3R2 SYNJ1 PIK3CB MTMR6 RAB5A PIK3R1 MTMR14 PIK3C2G PLEKHA1 PIK3C2A PI4K2A PLEKHA2 PIK3C2B PLEKHA5 PLEKHA6 PIK3CA PLEKHA3 PLEKHA4 PLEKHA8 ARF1 INPPL1 SBF2 PTPN13 OCRL RAB14 INPP4A INPP4B DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n RFT1 DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism MTR-1 MMADHC MTRR MMAA ABCD4 MMAB MCCC2 MMUT BTD PC CUBN PCCA HLCS MCCC1 TCN2 PCCB CD320 CBLIF ACACA LMBRD1 MMACHC AMN INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection RPS14 RPS17 NUP133 RPS16 RPS19 RPS18 NUP50 GBP2;GBP3;GBP1 POM121;POM121C NUP54 RPS11 RPL10A RPS10 RPS13 RPS12 POLR2A NUP42 POLR2B POLR2C RPL27A POLR2D NUP43 POLR2G POLR2I RAE1 RANBP2 IPO5 GRSF1 MLKL DNAJC3-1 RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 NUP35 RPS21 RPS24 RPS23 RPL36AL-1 RAN SLC25A6 NUP37 RPL7A CPSF4 RPLP0 HSP90AA1 CANX RPLP2 ISG15 RPL36-1 RPL35A RPS27L RPS15A HSPA1A;HSPA1B RPS3 CLTC XPO1 CLTA UBA52 RPS2 NUP214 CALR-1 RPL18A FAU KPNA7 RPL12-1 KPNA5 RPS27A KPNA3 KPNA2 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 KPNB1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 PARP1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A KPNA4-1 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 RPL15-1 KPNA1 TGFB1 NUP210 POLR2E POLR2F GTF2F1 RPL3L RPL5-1 POLR2H GTF2F2 NUP93 PABPN1-1 POLR2L NUP205 RPLP1-2 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 POLR2J;POLR2J2;POLR2J3 RPL23A EIF2AK2 NUP62 RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 NDC1 RPS15 SEC13 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE UNC93B1 TLR3 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RAI1 ARNTL MEF2D HELZ2 SIRT1 NRIP1 MED1 CRTC1 NPAS2 NR1D1 NCOR1 PPARGC1A TGS1 CREBBP ATF2 RORA RXRA CLOCK CARM1 CHD9 PPARA EP300 TBL1XR1 RORC MEF2C RORB NCOA1 NCOA2 NCOA6 CRTC2 SMARCD3 HDAC3 CRTC3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 PSMD12 KAT5 CHEK2 PSMD11 CHEK1 PSMD14 SFN CDC25A PSMD13 HUS1 PSMA7 PSMD8 PSMB6 DNA2 PSMB7 PSMD6 RHNO1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ATRIP YWHAE ADRM1 BARD1 ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 RAD17 PSMA6 ATM PSMC5 CDC6 PSMA3 PSMC6 ATR PSMA4 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 BRCA1 BABAM1 BABAM2 RMI2 UIMC1 YWHAB RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 H2BC5 UBA52 WRN H2BC1 YWHAZ RPA1 HERC2 CCNB2 RPA2 CCNB1 CDK2 RPA3 RPS27A RAD1 UBB;UBC CLSPN MCM10 DBF4 MRE11 NBN CDC25C CDK1 BLM GTSE1 PIAS4 UBE2N RAD9B H2BC21 RAD9A PKMYT1 YWHAQ EXO1 YWHAH TOPBP1 RFC5 RFC3 RFC4 TP53 RFC2 WEE1 UBE2V2 RBBP8 TP53BP1 RAD50 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 H2BC15;H2BC3;H2BC11;H2BC12 CDC45 MCM7 MCM8 NSD2 MCM3 MCM4 MCM5 MCM6 MCM2 BRIP1 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway IL36RN IL36G IL1F10 IL36A IL36B IL1RL2 M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase BUB1 CLASP2 BUB1B CDC20 CSNK2A1;CSNK2A3 FBXO5 PPP1CC BUB3 MAD2L1 PSMD12 GOLGA2 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 C1orf112 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 LPIN1 PSMB5 LPIN2 PSMB2 LPIN3 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE CEP57 CETN2 ADRM1 CEP164 CCP110 PSMC2-1 AKAP9-1 PSMA2-1 MAPRE1-1 PSMA5 PRKACA-1 SEM1 ACTR1A PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 LBR CNTRL PSMC6 PSMA4 CEP250 NEK2 PSMC3 PSMA1 CEP290 PSMC4 YWHAG PSMC1 CDK5RAP2 LEMD3 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 XPO1 CEP63 UBA52 PAFAH1B1 TNPO1 NUP214 DYNC1I2 DCTN2 SSNA1 PRKCA DCTN3 CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 ANKLE2 KIF20A CEP192 SET-1 RPS27A PCNT CEP76 CLASP1 UBB;UBC CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 PRKCB TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E DYNC1LI1 CEP41 DYNC1LI2 CEP43 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 IST1 SPAST CC2D1B KIF23 NUF2 KIF2A EMD NUDC KIF2C KIF2B INCENP CENPA CENPE CENPC CENPT NUP107 CENPU NUP188 RCC1 BANF1 NUP210 CENPF CENPH GORASP1 CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A LMNB1 CENPL NUP205 USO1 CENPM NEK9 NEK6 AAAS NEK7 CENPO PPP2R2A;PPP2R2D CENPP NUP160 NUP85 CENPQ TPR NUP88 TUBA1C TUBB1 NUP155 NUP153 CHMP2B CHMP2A TUBB2B;TUBB2A CLIP1 MAD1L1 NUP62 RB1 NDC1 H2AC14 SEC13 TUBB3;TUBB6 TUBAL3 NUP133 NDC80 RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 NUMA1 CHMP7 TUBG2 TUBA3E;TUBA3C-1 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 VPS4A TUBGCP4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SPDL1 NUP42 NUP43 RAE1 RANBP2 TUBA8 H2AC20 H2AB2;H2AB3;H2AB1 NSL1 NUP35 RAB1A RAN RAB1B NUP37 KNL1 ZW10 H2AJ CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 EML4 RCC2 ZWINT H2BC5 AHCTF1 H2BC1 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B H2AC4 PPP2R5E KMT5A VRK1 LEMD2 CTDNEP1 CNEP1R1 RAB2A GORASP2 BLZF1 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 KPNB1 UBE2I B9D2 H2BC21 SPC24 SPC25 ERCC6L ARPP19 NCAPH2 SUMO1 NCAPG2 ZWILCH NIPBL ENSA SIRT2 NCAPD3 PMF1;PMF1-BGLAP H2AZ2;H2AZ1 MAU2 MASTL MCPH1 KNTC1 BIRC5 SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CSNK2A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 MAPK1 ANAPC5 ANAPC1 ANAPC2 ITGB3BP VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels KCNH4 KCNH5 KCNH6 KCNS3 KCNH7 KCNH8 KCNB2 KCNAB1 KCNAB2 KCNAB3 KCNQ2 KCNS1 KCNQ3 KCNS2 KCNA10 KCNQ5 KCNQ4 KCND1 KCNQ1 KCND2 KCND3 KCNB1 KCNG1 KCNG3 KCNG4 KCNC1 KCNA1 KCNG2 KCNC3 KCNA2 KCNC4 KCNA3 KCNA5 KCNA4 KCNA6 KCNC2 KCNA7 KCNV1 KCNH2 KCNV2 KCNH1 KCNF1 KCNH3 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination ATM RAD50 BLM SPO11 BRCA1 PRDM7;PRDM9 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MSH4 MSH5 DMC1 PSMC3IP RAD51 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TOP3A MND1 MLH3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 RAD51C RPA1 RPA2 MLH1 CDK4 H2AC20 CDK2 C1orf112 H2AB2;H2AB3;H2AB1 BRCA2 H2AZ2;H2AZ1 RPA3 FIGNL1 H2AC4 MRE11 NBN RBBP8 H2AC14 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex ACTL6A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 BICRAL BICRA ACTB-1 BRD9 SMARCD1 SMARCD2 SS18 BCL7A SMARCD3 SS18L1 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function ARAF MRAS RAF1 YWHAB BRAF SHOC2 PPP1CB PPP1CC MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins PPP1CA FURIN CSNK2A2 CSNK2A1;CSNK2A3 PPP1CC CSNK2B SPCS3 SPCS2 SPCS1 KPNB1 SEC11A SEC11C XPO1 PPP1CB INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption RSC1A1 SLC2A5 SLC5A1-1 SLC2A2 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events PRKAR1B PRKAR1A GRIN2A RASGRF2 GRIN2B GRIN1 ADCY1 ADCY8 APBA1 PRKAB2 PRKACB-1 PRKAR2A CAMK4 PRKAB1 PDPK1 CAMK1 SRC CAMKK1 GRIA1 CAMKK2 GRIA3 GRIA4 DLG1 HRAS PRKAA1 CAMK2B CAMK2D CAMK2A PRKAG2 NRAS PRKACA-1 KIF17 CAMK2G PRKAA2 PRKAG1 GRIA2 RAC1 PRKAG3 NRG1 CALM3;CALM1 RPS6KA6 ACTN2 CASK LIN7A LIN7C GRIN2C GRIN2D GRIN3B GRIN3A DLG2 DLG3 DLG4 NBEA RASGRF1 PRKAR2B GIT1 NRGN RPS6KA3 RPS6KA2 NEFL KPNA2 RPS6KA1 LRRC7 PRKX LIN7B MAPK1 PPM1E PPM1F MAPK3 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CA1 ARF1 RPLP0 GSTO1 GSTA3;GSTA5;GSTA1;GSTA2 PITPNA LMNB1 CNN2 HNRNPDL AIP CFL1 STAT4 HSPA9 PAK2 IL10 SERPINB2 ANXA2 MSN MIF RALA-1 SOD2 TALDO1 SOD1 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 CDC42 LCP1 PPIA MTAP TCP1 CAPZA1 RAP1B NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 PACS1 AP1S1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E AP1S3 AP1M2 AP1B1 AP1M1 B2M SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells KCNMB1 KCNMA1 CHRNA9 CHRNA10 KCNN2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport TIMMDC1 ETFDH NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 SURF1 NDUFS5-1 COX7B COX7C SCO1 UQCRC1 UQCRC2 COX8A SCO2 COX8C HSCB TMEM126B COA3 COX5B ACAD9 COX5A SFXN4 NUBPL COX6C NDUFAB1 COA5 TACO1 ECSIT COX6A1 COX6A2 COQ10A-1 SDHC SDHD SDHA COX6B2 SDHB CYC1 COX6B1 NDUFV3 NDUFV2 NDUFV1 COX19 GOT2-1 NDUFB10 DMAC2 COX15 NDUFB11 COX18 PET117 COX17 CMC1 CYCS-1 HIGD1A UQCRFS1 COX11 COX14 MDH1 HIGD2A MDH2 NDUFS8 NDUFS7 NDUFS6 SMIM4 COX20 LETM1 NDUFS4 NDUFS3 LYRM2 NDUFS2 TMEM223 NDUFS1 LYRM4 LYRM7 UQCRB NDUFC2;NDUFC2-KCTD14 C12orf73 TRAP1 GOT1-1 HCCS UQCRQ TTC19 ETFA COX4I1 ETFB COX4I2 NDUFC1 SLC25A18 COX7A2L-1 FXN UQCR11 NDUFA13 SLC25A12 SMIM20 UQCR10 NDUFA11 NDUFA12 SLC25A11 NDUFA10 SLC25A13 NDUFB9 NDUFB8 NDUFB7 NDUFB6 FOXRED1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCC3 OXA1L UQCC2 UQCC1 COX7A2 HSPA9 TMEM186 TMEM126A-1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 RAB5IF NDUFA6 TIMM21 BCS1L COQ10B NDUFA4 TMEM177 NDUFA3 PYURF HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 KAT5 POLH CHEK1 HUS1 MUS81 C1orf112 EME1-1 BRCA2 DNA2 RAD51AP1 RHNO1 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 SIRT6 PALB2 SPIDR SLX1A;SLX1B ATRIP BARD1 SEM1 RAD17 ATM ATR BRCA1 BABAM1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 RAD51D H2BC5 PCNA UBA52 WRN H2BC1 RPA1 HERC2 RPA2 CDK2 RPA3 RPS27A RAD1 UBB;UBC CLSPN MRE11 NBN RTEL1 ABL1 BLM PIAS4 RAD51 UBE2I POLD1 UBE2N RAD9B H2BC21 RAD9A RAD51B RAD51C EXO1 SUMO2 TOPBP1 RFC5 RFC3 RFC4 RFC2 UBE2V2 RBBP8 TP53BP1 RAD50 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 RNF168-1 PPP4R2 TIPIN TIMELESS PPP4C POLK RAD52 POLE RFC1 H2BC15;H2BC3;H2BC11;H2BC12 NSD2 POLD3 POLD4 POLD2 POLE4 BRIP1 ERCC4 POLE2 RNF4 ERCC1 POLE3 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation HOXC4 HOXA2 PBX1 PAXIP1 CNOT6 YY1 DPY30 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B PAGR1 POLR2C PAX6 CREBBP POLR2D CTCF H2BC21 POLR2G POLR2I CNOT9 WDR5 RXRA KDM6A H2AC20 EED RARA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EZH2 HOXB4 ASH2L NCOA6 NCOA3 HDAC3 JUN RARG RBBP4 RBBP5 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 POLR2E RARB POLR2F POLR2H RBBP7 HOXA3 POLR2L HOXA1 PKNOX1 HOXA4 PIAS2 HOXB3 H2BC15;H2BC3;H2BC11;H2BC12 HOXB2 SUZ12 HOXB1 H2BC5 AJUBA HOXD1 PCGF2 MEIS1 H2BC1 MAFB HOXD4 HOXD3 ZNF335 POLR2J;POLR2J2;POLR2J3 EP300 EGR2 H2AC4 KMT2D KMT2C H2AC14 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling ALK PTN PTPRZ1 MDK SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions BCL2L11 MARK3 TRAK1 FXR1-1 FAM114A2 KDM7A JAK2 AGK CLCN6 VCL TLN1 ZC3HAV1 SRC FN1 IQGAP1 LMNA ARRB2 FAM131B CSK HRAS CAMK2B AKAP9-1 CAMK2D CAMK2A KIAA1549 RAP1B NRAS ESRP1 CAMK2G TRIM24 ARAF CALM3;CALM1 MPRIP AGTRAP RAF1 CNKSR2 YWHAB ITGB3 SND1 CNKSR1 AGGF1 PEBP1 FGB FGA ARRB1 FGG ITGA2B TENT4A VWF AP3B1 MAP2K2;MAP2K1 QKI PAPSS1 RAP1A MAPK1 ATG7 BRAF KSR1 MAPK3 KSR2 APBB1IP SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants RNF43 WNT3A FZD5 FZD4 FZD6 LRP5 FZD8 LRP6 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling CAMK2G RASGRF2 GRIN2B CALM3;CALM1 GRIN1 RPS6KA6 ACTN2 GRIN2D DLG2 DLG3 DLG4 RASGRF1 PDPK1 RPS6KA3 RPS6KA2 NEFL RPS6KA1 DLG1 LRRC7 MAPK1 HRAS MAPK3 CAMK2B CAMK2D CAMK2A NRAS NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TXN UBE2V1 BCL2 MAP2K6 BCL2L1 IRAK1 IRAK2 NLRP3 UBE2N TAB3 CASP5;CASP4 MAPK13 TAB2 TAB1 HSP90AB1 ITCH APP NLRC4 MEFV NFKB2 PANX1 PYCARD CASP2 P2RX7 PSTPIP1 AIM2 CASP1 TXNIP TRAF6 NLRP1 SUGT1 CARD9 NOD1 NOD2 RIPK2 AAMP TNFAIP3 CYLD HMOX1 BIRC2 CHUK BIRC3 CASP8 IKBKB IKBKG RELA NFKB1 MAP3K7 CASP9 MAPK14 MAPK11 MAPK12 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin FDXR FDX1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs RIPK3 TBK1 MYD88 NFKBIB RELA NKIRAS1 TLR3 NKIRAS2 NFKB2 CHUK TICAM1 IRF3 DHX9 RIPK1 NFKB1 IKBKB NLRP4 IKBKG ZBP1 NFKBIA DTX4 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis HDAC1 POU3F2 DICER1 BIRC7 TNRC6C MOV10 TNRC6A-1 AGO4 BCL2 AGO2 BCL2A1 AGO3;AGO1 TNRC6B TRPM1 HINT1 SIN3A STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants GRB2 PTPN11 NOX4 STAT5A CDKN1A STAT5B GAB2 FLT3 PIM1 BCL2L1 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines SMYD2-1 RBBP4 RBBP5 SMYD3 PRDM7;PRDM9 AEBP2 RBBP7 PRDM16 MECOM SUV39H2 SETD2 DPY30 ATF7IP SETD3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SETD6 SETD7 SUZ12 SETDB1 SETD1B SETD1A ASH1L WDR5 DOT1L RELA NSD3 NSD1 NFKB2 NSD2 EED EZH2 SUV39H1 ASH2L NFKB1 KMT5A KMT2D KMT5B EHMT2 KMT2A EHMT1 KMT2C KMT2B KMT5C DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells FGF10 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis GNS AP4B1 ARF1 HGS CLTC CTSZ CLTA AP4E1 ARRB1 AP4M1 AP1G2 AP1G1 DNASE2 CLVS2 AP1S2 DNM2 VAMP2 AP1S1 AP4S1 APP AP1S3 CLVS1 SH3GL2 AP1B1 VAMP7 VAMP8 DNAJC6 M6PR CHMP2A CLTB BLOC1S1 HSPA8 AP1M2 TXNDC5 AP1M1 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine ACSM1 GLYATL3 ACSM2A;ACSM2B GLYAT CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway GNG10 GNG2 GNG5 GNG4 GNG8 WNT11 GNG13 GNB2 GNB1 GNAT2 GNB4 GNB3 ITPR1 WNT5A ITPR2 GNB5 LEF1 ITPR3 NLK PPP3R1 FZD3 FZD2 FZD5 FZD4 FZD6 NFATC1 GNAO1 PPP3CA PPP3CB PRKG1 PDE6B PDE6A CAMK2A PRKG2 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 CTNNB1 TNRC6B TCF7 CALM3;CALM1 TCF7L1 GNGT1 PRKCA PLCB3 TCF7L2 PLCB1 PLCB2 MAP3K7 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation SOS1 CD19 CD22 NCK1 PIK3AP1 PSMD12 PSMD11 ITPR1 PSMD14 ITPR2 PSMD13 ITPR3 PPP3R1 PSMA7 CD79B PSMD8 CD79A PSMB6 FKBP1A PSMB7 PSMD6 PSMB4 NFATC2 PSMD7 PPIA NFATC1 PIK3CD PSMB5 SYK PSMB2 PSMB3 PPP3CA PSMD2 PPP3CB PSMD3 PSMB1 PSMD1 HRAS PIK3R1 FYN ADRM1 TRPC1 PSMC2-1 PSMA2-1 PSMA5 NRAS SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PTPN6 PSMA4 NFKBIB BTRC PSMC3 PSMA1 BLK PSMC4 PSMC1 SKP1 PLCG2 BLNK CHUK BTK DAPP1 REL FBXW11 CALM3;CALM1 RASGRP3 NFKBIE IKBKB CARD11 BCL10 IKBKG RASGRP1 MALT1 LYN UBA52 NFKBIA NFATC3 STIM1 CUL1 ORAI2 RELA ORAI1 SH3KBP1 RPS27A AHCYL1 UBB;UBC NFKB1 MAP3K7 VAV1 PRKCB SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM NCBP1 POLR2I FGFR2 POLR2J;POLR2J2;POLR2J3 NCBP2-1 FGF2 POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L POLR2A POLR2B FGF1 POLR2C POLR2D POLR2G REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2R1B PPP2R1A PFKFB2 PFKFB1 PFKFB4 PRKACB-1 PFKFB3 PPP2CB;PPP2CA PPP2R5D PRKACA-1 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 CYP2U1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity TGIF1-1 HDAC1 SNW1 UBE2D3-1 USP9X NCOR2 WWTR1 NCOR1 NEDD4L UBA52 PARP1 SMAD2;SMAD3 UBE2D1 PPM1A ATP1B4 TGIF2 SKI RPS27A SMAD4 SMURF2 UBB;UBC SMAD7 RNF111 MAPK1 MAPK3 SKIL TRIM33 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels KCNK9 KCNK10 KCNK3 KCNK6 KCNK13 KCNK7 KCNK16 KCNK1 KCNK18-1 KCNK17 KCNK2 KCNK4 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation TYK2 IL6 MAP2K2;MAP2K1 PTPN11 MAPK1 JAK1 JAK2 IL6R TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions CLDN20 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 CLDN5 CLDN18 CLDN17 CLDN16 CLDN1 CLDN22;CLDN24-1 PARD6G MPP5 F11R PARD3 PARD6B CRB3 PARD6A PRKCI CLDN2 CLDN6 CLDN4 CLDN3 CLDN9 CLDN8 CLDN7 PATJ CLDN23-1 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling NGF SMPD2 NGFR RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases S100A8 NCF1 PRKCD PRKCA NCF2 NCF4 NOXO1 RAC1 NOXA1 PRKCZ PIK3C3 CYBB MAPK14 MAPK1 CYBA MAPK11 NOX3 MAPK3 NOX1 PRKCB PIN1 PIK3R4 S100A9 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability CTNND1 MTOR AKT2 NOS3 AKT3 CTNNB1 PAK1 RAC1 HSP90AA1 CTNNA1 PAK3 CALM3;CALM1 JUP CAV1 AKT1 PAK2 THEM4 RICTOR PRR5 CDH5 PDPK1 MLST8 VAV3 TRIB3 MAPKAP1 VAV1 VAV2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein DPM1 DPM2 MVD DPM3 ST8SIA5 ST6GAL1 CTSA DPAGT1 MPI ST3GAL4 ST6GALNAC2 DOLK ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 SRD5A3 SLC35C1 ST6GALNAC1 CMAS NPL NANP ST6GALNAC3 ST6GALNAC4 NEU4 NAGK AMDHD2 ST8SIA4 NANS GFPT2 ST6GAL2 GFPT1 PGM3 ST8SIA1 GNPNAT1 ALG14 GNE ALG12 UAP1 ALG11 RENBP ST3GAL6 ST6GALNAC5 GLB1 ST6GALNAC6 ALG8 ST3GAL5 ALG9 ALG6 ALG5 ALG2 NUDT14 ALG3 ALG1 RFT1 MPDU1 DHDDS PMM2 GMPPB FPGT GMPPA GFUS DHRSX GMDS ST8SIA6 NUS1 PMM1 ST8SIA2 FCSK DOLPP1 ST8SIA3 ALG10;ALG10B HK1 NEU2 NEU3 SLC17A5 NEU1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism DLD BCAT2 ALDH6A1 MCCC2 GLYAT ECHS1 IVD ACAD8 MCCC1 SLC25A44 CRAT BCKDHA PPM1K DBT BCKDHB ACADSB HSD17B10 HIBADH BCKDK HIBCH ACAT1 BCAT1 AUH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB ALDH1A1 KHK TKFC GLYCTK ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase HSP90AB1 DNAJB1 HSPA1L HSBP1 HSF1 HSP90AA1 EP300 PTGES3-1 HSPA8 HSPA1A;HSPA1B HSPA2 CREBBP FKBP4 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations POMT2 POMK POMGNT2 DAG1 B3GALNT2-2 POMT1 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) GATA3 HDAC11 BMI1 ETS1 YY1 IL4R HDAC4 DPY30 KLF13 CHD4 RING1 CHD3 IL13 MAF IRF4 CREBBP HDAC5 HDAC8 SATB1 HDAC9 NOTCH1 RNF2 HDAC6 HDAC7 STAT6 SMARCA4 RBPJ WDR5 CBX8 STAT5A STAT5B CBX6 PHC2 PHC1 POU2F1 CBX4 MAML2 CBX2 MAML1 NFATC2 ASH2L POU2F2 PHC3 BATF IL4 IL5 MAML3 NOTCH2 HDAC2 HDAC3 HDAC1 JUN SNW1 MAMLD1 MTA1 HDAC10 RBBP4 NCOR2 RBBP5 KAT2B KAT2A NCOR1 RBBP7 MTA2 MTA3 FOS MBD3 GATAD2B GATAD2A EP300 MEN1 TBL1XR1 KMT2A MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS36 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 GFM2 MRPL27 MTRF1 MRPL28 MTRF1L ERAL1 MRRF MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia RFX2 RFX3 CCNO TNRC6C MOV10 TP73 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 GRHL3 TNRC6B GRHL2 DEUP1 GMNC FOXJ1 MYB NOTCH1 DLL1 E2F4-1 E2F5 TFDP1 GMNN GRHL1 MCIDAS DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes SMAD2;SMAD3 BTG1 FOXG1 CDKN1A CDKN1B FOXO4 FOXO3 SMAD4 MSTN FOXO1-1 KLF4 PCBP4 RBL2 CAV1 CCNG2 GADD45A SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks KAT5 ATM KPNA2 RAD50 MRE11 NBN SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 CHKB ETNPPL CHKA PISD ETNK2 ETNK1 PHOSPHO1 LPIN1 LPIN2 SELENOI LPIN3 CEPT1 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic COG4 RAB33B-1 STX5 COG3 YKT6 COG2 RGP1 BET1L RAB30 RAB36 ARF1 VPS45 TRIP11 ALPG;ALPP;ALPI-1 MAN2A1 GOSR2 NAPB MAN1A2 MAN1C1 NAPG MAN1A1 RAB39A COG1 MAN2A2 NAPA NSF STX16 GOSR1 GOLIM4 CYTH3 CYTH2 GOLGA5 CYTH4 CUX1 STX6 VTI1A CYTH1 COG8 COG7 RIC1 COG6 SNAP29 COG5 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs APAF1 CASP3 DIABLO-1 CASP9 CASP7 CYCS-1 XIAP ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion PDS5A STAG2 WAPL SMC1A ESCO1 ESCO2 SMC3 RAD21 CDCA5 STAG1 PDS5B FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm NCBP1 NUP133 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 NUP50 GLE1 POM121;POM121C NXF2;NXF2B;NXF5-1 THOC1 NUP54 THOC3 THOC2 THOC5 SYMPK CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 FIP1L1 SRSF3 NUP42 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A NUP43 POLDIP3 SRSF1 NXF1 SLBP U2AF2 RAE1 FYTTD1-1 RANBP2 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NCBP2-1 CPSF2-1 NUP35 NUP37 CPSF4 CPSF1 CPSF3 NUP107 NUP188 EIF4E NUP210 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 WDR33 NDC1 SEC13 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency EIF2AK1 CEBPB ATF4 GRB10 CHAC1 DDIT3 EIF2S2 ATF3 EIF2S3;EIF2S3B TRIB3 EIF2S1 ASNS CEBPG PPP1R15A ATF5 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs NUP133 NUP107 NUP188 NUP50 POM121;POM121C BANF1 NUP54 KPNA1 NUP210 NUP93 PSIP1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation SCN1A CAMK2G FGF14 FGF13 FGF12 FGF11 SCN3B SCN3A CALM3;CALM1 SCN2A CACNG6 SCN2B RANGRF CACNG8 CACNB2 CACNA2D2 SCN9A CACNG4 SCN8A SCN11A SCN10A SCN5A CACNA1C SCN4A SCN4B SCN7A CACNG7 CAMK2B CACNB1 CAMK2D CAMK2A SCN1B NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling NTRK2 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia F8 F9 F10 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape TAF1D TAF1B RRN3 TAF1C H2AJ TAF1A CDK7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H MNAT1 POLR2L H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 H2BC21 H2BC1 ERCC2 GTF2H1 GTF2H3 UBTF GTF2H4 H2AC20 PHF6 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 POLR1A POLR1B POLR1C H2AC4 POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 CCNH H2AC14 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex TRAF6 IKBKB UBE2V1 IKBKG PELI1 CHUK UBE2N IRAK1 PELI3 PELI2 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers PHF5A SNRPD2 SNRPD1 SNRPN SNRPD3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SNRPE-2 H2AC20 H2AB2;H2AB3;H2AB1 SSRP1 CBX3-1 MAFK NFE2L2 CTNNB1 H2AJ CDC73 TCF12 LEO1 AXIN2 SF3B1 MBD3 H2BC5 MBD2 H2BC1 GATAD2B GATAD2A CHD9 EP300 H2AC4 CHD2 TCF4 SNRPF SNRPB CTR9 RTF1 MYOG PAF1 FBP1 DHX15 MYOD1 UBE2I CHD4 G6PC1 CHD3 CHD8 CHD7 CHD6 CTCF H2BC21 NKD2 FAM124B IGF2 PWWP2B DDX46 DDX42 CHD5 IKZF1 WDR5 IKZF2 SUMO1 RBM17 IKZF3 PHF6 MBD3L1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 ADNP2 ZNF687 TCF19 ADNP ZNF592 ZNF827 SMNDC1 CBX1 U2SURP NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 DKK2 SNRPG-2 HDAC2 NR2C2 HDAC1 SF3B4 SF3B5 MTA1 SF3B2 SF3B3 RBBP4 NQO1 SF3B6 SF3A3 SF3A1 SUPT16H H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SF3A2 RBBP7 MTA2 MTA3 CHERP H2BC15;H2BC3;H2BC11;H2BC12 PUF60 SNRPB2 SNRPA1 WDR61 PCK1 H2AC14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma ALB HBA2;HBA1 CD163 HPX APOL3;APOL4;APOL1;APOL2 APOA1 AMBP LRP1 JCHAIN HP;HPR HBD;HBB HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4A PLBD1 GPCPD1 PLA2G15 PLA2G4F JMJD7-PLA2G4B;PLA2G4B PLA2G4D PLA2G4E LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling NOTCH1 CUL1 RBX1 SKP1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 EIF5 RPL37A-1 RPL26L1 RPL4 RPL30 EIF5B RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2B1 EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification RBX1 CSNK2A1;CSNK2A3 GSK3B DERL3 OST4 DERL1 SPOP PRKAB2 RPN2 OSTC STT3A RPN1 STT3B PSMD12 PSMD11 PSMD14 PSMD13 PRKAB1 PSMA7 PSMD8 DDOST PSMB6 PSMB7 PSMD6 DAD1 PSMB4 PSMD7 ERLEC1 PSMB5 CD274 PSMB2 PSMB3 PSMD2 PSMD3 B3GNT3 PSMB1 MAGT1 PSMD1 JAK1 PRKAA1 ADRM1 CUL3 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 MIB2 BTRC CSNK2A2 PSMC3 PDCD1 PSMA1 PRKAA2 YWHAG PSMC4 PRKAG1 PSMC1 SKP1 PRKAG3 CCND1 CSNK2B UBA52 ERLIN1 ERLIN2 CUL1 CDK4 PDCD1LG2 VCP-1 RPS27A TUSC3 DERL2 RNF5 UBB;UBC OS9 COPS5 RNF185 TMEM258 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RHOA MET RND1 RRAS ARHGAP35 RAC1 SEMA4D PLXNB1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K BDNF GAB1 PIK3CA PIK3R1 NTRK2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins SCN1A SPTBN2 ANK2 KCNQ2 KCNQ3 SPTBN4 SPTBN5 ANK1 SCN3B SCN3A SCN2A SCN2B SPTBN1 SCN9A NRCAM SCN8A SPTA1 SCN11A SCN10A SPTAN1 L1CAM SCN5A SCN4A SCN4B SPTB SCN7A ANK3 NFASC SCN1B RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle WDR6 ARHGEF7 SRGAP2 PTK2B DST ARHGEF6 USP9X TXNL1 WWP2 PAK1 VANGL1 PAK3 DEPDC1B HGS MYO6 PAK4 GIT2 DLG5 NCK2 SPTBN1 NCK1 STAM EPHA2 CLTC ARHGAP31 PAK2 ARHGAP30 ITSN2 SRC SPTAN1 GIT1 CDC42 PARD6A IQGAP1 PIK3R2 PIK3R1 PEAK1 STAM2 RHOU ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis TRDN ASPH NOS1 ATP1A4 ATP1A3 ABCC9 ATP1A2 ATP1A1 TNNI3 ATP1B3-1 FXYD2;FXYD6-FXYD2 ITPR1 ITPR2 ITPR3 FKBP1B CAMK2B TRPC1 CAMK2D CAMK2A PRKACA-1 CAMK2G SLC8A3 ATP2B4 ATP2A3 ATP1B2 ATP2B3 ATP2A2 ATP1B1 KCNJ11 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 DMPK AHCYL1 FXYD4 FXYD3 FXYD1 FXYD6 RYR1 RYR2 RYR3 CLIC2 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling TNFAIP3 TBK1 UBE2D3-1 CYLD UBA7 PCBP2 DDX58 NLRC5 ISG15 UBE2L6 HERC5 RNF135 IFIH1 OTUD5 TRIM25 MAVS UBE2D3;UBE2D2 PIN1 UBA52 UBE2K ITCH UBE2D1 TAX1BP1 RNF125 RNF216 IRF3 RPS27A TRAF3 ATG12-1 UBB;UBC ATG5 IKBKE NLRX1 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation FGG F2 ITGA2B SERPINC1 SERPIND1 PROC F13B SERPINE2 ITGB3 F13A1 SERPINA5 FGB FGA PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism PCCB MCEE MMAA MMUT PCCA CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis BCAN VCAN CHST11 CHST3 CHST12 CHPF2 CHSY3 CHST15 CSPG5 CHST7 CHSY1-1 UST CHST13 CHPF CSGALNACT1 DCN CSGALNACT2 NCAN BGN DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation MET HGF PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 CDK1 CCNB1 FZR1 PLK1 CDC20 FBXO5 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery CCNK CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDK6 E2F2 CDKN1A CDKN1B CDK4 CDK2 CCND1 TFDP1 TFDP2 CCNE2 CCNE1 RB1 CDKN1C CCND3 E2F1 CCND2 E2F3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 PTGS2-2 ALOX15B GPX1 ALOX15 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade CLEC1B PIK3CA PTPN11 PTPN6 PIK3R3 PIK3R6 PIK3R5 PLCG2 RAC1 PRKCZ PDPN MPIG6B GP6 LCP2 RHOA LYN FCER1G LCK PDPK1 VAV3 LAT CDC42 RHOG PIK3CG SYK PIK3R2 PIK3CB VAV1 VAV2 PIK3R1 RHOB FYN CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) CASR GRM8 TAS2R7 GABBR2 TAS2R8 TAS2R42 GABBR1 TAS2R3-1 GRM4 GPRC6A TAS2R1 TAS2R4 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GRM1 TAS2R16 GRM5 TAS2R40 TAS2R41 PRH1-TAS2R14;TAS2R14-3 TAS1R2 TAS1R1 TAS2R39 TAS1R3 GRM3 GRM2 GRM7 GRM6 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation GJA1 GJC1 GJB2 GJC2 GJB1 GJA3 MYO6 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 CLTC GJB3 CLTA GJB6 GJB5 GJB7 DNM1 DNM2 TJP1 CLTB DAB2 CLTCL1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex KPNB1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 H2AC20 PSMD8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 PSMA5 ORC1 ORC3 SEM1 PSMA6 ORC2 CDT1 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 H2AJ KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 UBA52 H2BC1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 MCM7 ANAPC11 MCM8 FZR1 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 RPS27A MCM6 MCM2 UBE2C UBE2E1 H2AC4 UBB;UBC KPNA6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 H2AC14 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1-1 HDAC1 CCNK CCNT1 CDK8 WWTR1 COL1A2 CCNC-1 CDKN2B SP1 UBA52 SMAD2;SMAD3 FURIN CDK9 TGIF2 EP300 CCNT2-1 E2F4-1 RPS27A E2F5 SMAD4 MEN1 UBB;UBC SERPINE1 TFDP1 JUNB SMAD7 RNF111 TFDP2 MAPK1 RBL1 MAPK3 YBX1 MYC MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation CDK1 TYK2 IL6 MAP2K2;MAP2K1 PTPN11 JAK1 MAPK3 JAK2 IL6R ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 POLR2I SUPT4H1-1 SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 POLR2E POLR2F CTDP1 GTF2F1 POLR2H GTF2F2 POLR2L POLR2A NELFB POLR2B POLR2C NELFCD NELFA POLR2D NELFE POLR2G EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events RALA-1 MAPKAPK2 MAPK14 HRAS MAPK11 MAPKAPK3 MAPK12 RALGDS RALB MAPK13 NRAS PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere BLM RPA1 RPA2 ACD TINF2 POLD3 TERF2 POLD4 DNA2 RPA3 POLD2 POT1 TERF2IP LIG1 TERF1-1 FEN1 POLD1 PCNA WRN DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency TCN2 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication MGME1 RNASEH1-1 POLRMT POLG2 EXOG POLG TWNK TOP3A SSBP1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation AP2A2 NR1H3 AP2S1 MYLIP RPS27A UBB;UBC VLDLR NR1H2 PCSK9 CLTC CLTA AP2A1 UBA52 AP2B1 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis ABL1 ARPC4 ARPC5 WAS ARPC2 ARPC3 YES1 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A WASL ACTG1 CD3G CDC42 SYK FGR HCK FCGR3A;FCGR3B FYN WASF2 WASF3 BAIAP2 NCKIPSD RAC1 MYO10 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK DOCK1 LYN PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs ALOX15 ALOX12 HPGD LTA4H PTGS2-2 GSTM4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 LTC4S ALOX5 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants ALK CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA POLR3GL POLR3A POLR3B TBK1 POLR3C TRIM56 POLR3D PRKDC POLR3E POLR3F POLR3G POLR3H DHX36 POLR3K TRIM32 CREBBP ZBP1 DTX4 RIPK3 STAT6 LRRFIP1 NFKB2 IRF3 AIM2 POLR1C IRF7 POLR1D MYD88 NFKBIB NKIRAS1 TLR3 NKIRAS2 CGAS CTNNB1 CHUK TICAM1 POLR2E DHX9 RIPK1 POLR2F POLR2H IKBKB POLR2L DDX41 IKBKG UBA52 NFKBIA XRCC6 RELA XRCC5 TRIM21 STING1 EP300 RPS27A UBB;UBC NFKB1 IFI16 NLRP4 MRE11 TREX1 CRCP PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors GNB3 GNGT1 GNB5 GNG10 GRIK3 GNG2 GNG5 GNG4 PLCB3 GNG8 PLCB1 PLCB2 GNG13 GNB2 GNB1 GNB4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins BCL2L11 BAD TP73 BCL2 PMAIP1 YWHAG AKT2 BMF AKT3 BID BBC3 PPP3CC YWHAB AKT1 SFN TP63 YWHAZ PPP1R13B PPP3R1 YWHAQ YWHAH TP53 TFDP1 TFDP2 TP53BP2 YWHAE MAPK8 E2F1 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 BDNF RAC1 DOCK3 NTRK2 SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 G6PC3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation RPS14 RPS17 RPS16 MARS1 RPS19 RPS18 N6AMT1 RPS11 GSPT2 GSPT1 RPL10A RPS10 RPS13 RPS12 RARS1 ETF1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H RPL27A EIF3M EIF3K EIF3L PSMD12 EIF3I EIF3J PSMD11 EIF3G PSMD14 EIF3H LARS1 MRPS17 PSMD13 EIF3E C12orf65 GFM1 EIF3F MRPS15 MIEF1 EIF3D MRPS16 MALSU1 EIF3A MRPS14 PSMA7 MTFMT EIF3B MRPS11 MTIF2 PSMD8 MRPS12 MTIF3 MRPL38 MTRES1 MRPL39 PSMB6 MRPS10 PSMB7 PSMD6 RPS25 MRPL36 RPS27 MRPL37 PSMB4 PSMD7 RPS29 MRPL34 MRPL35 PSMB5 SRP14 RPS20 MRPL32 PSMB2 RPS21 MRPL41 PSMB3 PSMD2 AARS1 RPS24 MRPL4 PSMD3 HARS1 RPS23 MRPL42 PSMB1 YARS1 MRPL3 PSMD1 RPL36AL-1 MRPL2 WARS1 MRPL40 GARS1 NARS1 MRPL1 FARSA MRPL9 ADRM1 CHCHD1 CARS1 TARS1 MRPS28 PSMC2-1 FARSB TSFM MRPS26 PSMA2-1 VARS1 MRPS27 PSMA5 MRPS24 SEM1 MRPS25 PSMA6 MRPS22 PSMC5 MRPS23 PSMA3 MRPL49 PSMC6 MRPS18B PSMA4 MRPS21 MRPS2 PSMC3 MRPS18A PSMA1 MRPL47 PSMC4 MRPL48 PSMC1 EEF1B2-1 MRPS7 EEF1G MRPL46 EEF1A1 MRPS6 EEF1D MRPL43 EEF1A2 MRPS5 EEF2 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 RPS27L MRPS9 MRPL51 RPS15A AURKAIP1 DAP3 MRPL18 RPS3 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 UBA52 MRPS35-1 MRPL17 RPS2 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 RPL18A MRPL20 FAU PTCD3 RPL12-1 VCP-1 GADD45GIP1 MRPL27 RPS27A MRPL28 ERAL1 MRPL24 MRPL21 UBB;UBC MRPL22 MRPL30 RPS9 LOC107987373;MRPL23 RPS7 PABPC1;PABPC3 RPS8 RPS5 DARS1 RPS6 EIF4G1 RPSA TUFM RBX1 RPL26L1 RPL4 APEH RPL30 RPL3 RPL32 RPL31 RPL34 ZNF598 ASCC2 RPL8 ASCC3 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2B1 EIF2S1 RPL3L RPLP1-2 ABCE1 PPA2 RARS2 AARS2 PARS2 MARS2 DARS2 HARS2 YARS2 ELOC-1 FARS2 RPL11 WARS2 LARS2 RPL14 SARS2 SRPRB-1 ELOB RPL13 NARS2 TARS2 RPL18 RPL17 IARS2 RPL19 VARS2 CARS2 EARS2 AIMP1 AIMP2 EPRS1 SEC11A SEC11C SSR1 EEF1E1 MRPS36 RPL10;RPL10L-1 SPCS3 SPCS2 SPCS1 RPL7A NDUFAB1 UBE2D3-1 SARS1 RPLP0 SRPRA TRMT112 RPLP2 SRP19 TRAM1 RPL36-1 RPL35A SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 ANKZF1 KLHDC10 NPLOC4 KARS1 TCF25 UFD1 NEMF RPL22L1 EIF5 RPL37A-1 EIF5B QARS1 LTN1 SEC61A2 SEC61A1 SEC61G SEC61B PPA1-1 CUL2 RPL13A-1 RPL5-1 OXA1L UBE2D3;UBE2D2 IARS1 UBE2D1 RPL23A GFM2 MTRF1 MTRF1L MRRF RCHY1 RPS15 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes MAFK NFE2L2 CREBBP EP300 CCL13;CCL2 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants FLT3 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling BCL2L11 MARK3 TRAK1 FXR1-1 FAM114A2 PPP1CC MAP3K11 DUSP6 DUSP7 KDM7A JAK2 AGK CLCN6 VCL TLN1 ZC3HAV1 SRC FN1 DUSP8 IQGAP1 SPRED3 DUSP9 LMNA ARRB2 SPRED2 SPRED1 FAM131B CSK HRAS CAMK2B AKAP9-1 CAMK2D BRAP PPP1CB CAMK2A KIAA1549 RAP1B NRAS ESRP1 NF1 CAMK2G MRAS TRIM24 ARAF KRAS CALM3;CALM1 MPRIP AGTRAP RAF1 CNKSR2 YWHAB ITGB3 SND1 CNKSR1 AGGF1 PEBP1 DUSP16 DUSP10 FGB FGA ARRB1 FGG ITGA2B TENT4A VWF AP3B1 MAP2K2;MAP2K1 QKI PAPSS1 RAP1A MAPK1 ATG7 BRAF KSR1 PHB MAPK3 KSR2 SHOC2 APBB1IP SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses NUP133 TLR2 TBK1 NUP50 POM121;POM121C NUP54 B2M ATG14 NUP42 SAR1B CREBBP PIK3R4 NUP43 RAE1 RANBP2 NUP35 IKBKE JAK1 TOMM70 NUP37 RIPK2 SFTPD TYK2 IL17RC IL17RA CHUK HSP90AA1 SIKE1 DDX58 TLR8 ISG15 TLR7 IFIH1 RNF135 IKBKB TRIM25 IKBKG NUP214 STAT1 STAT2 SEC24D-1 NLRP12 STING1 IL17F IL17A KPNA2 MAP3K7 MASP1 UBE2V1 IFNAR1 TKFC IRAK1 IRAK2 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E MAVS UBE2N TAB3 TAB2 TAB1 HSP90AB1 LARP1-1 IRF3 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 BECN1 SEC23A NOD1 NOD2 CNBP-1 SEC24B IFNB1-4 SEC24A PTPN11 PTPN6 NUP107 NUP188 SEC24C NUP210 NUP93 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NUP62 TLR1 NDC1 SEC13 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DOLK MVD SRD5A3 DHRSX NUS1 DOLPP1 DHDDS DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGF20 FGF23 FGFR3 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes ME1 NFE2L2 IDH1 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin INHA SMAD2;SMAD3 FST FOXH1 SMAD4 TGFBR3 MAPK1 MAPK3 ACVR1B INHBB INHBA FSTL3 ACVR1C ACVR2B DRAP1 ACVR2A LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer SMAD2;SMAD3 SMAD4 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion CD4 CXCR4 CCR5 PPIA YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression HIPK1 TEAD1 TEAD2 KAT2B TEAD3 HIPK2 YAP1-1 TEAD4 WWTR1 TBX5 GATA4 NKX2-5 NPPA CCN2 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling SYK LCK SHC1-1 PTK2B STAT5A IL2RA IL2 STAT5B IL2RB IL2RG JAK1 JAK3 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis ADSS1 PPAT ADSL IMPDH1 ADSS2 ATIC IMPDH2 PAICS GMPS PFAS GART DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHCG RHBG RHAG SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer SMAD2;SMAD3 SMAD4 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells NR5A1 SMAD2;SMAD3 DPPA4 STAT3 EPHA1 PBX1 PRDM14 FGF2 LIN28A SMAD4 ZIC3 ZSCAN10 TDGF1 SALL4 SALL1 KLF4 POU5F1;POU5F1B SOX2 FOXD3 NANOG;NANOGP8 EPAS1 HIF3A SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants KRAS HRAS NRAS DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 CADM3 CADM1 NECTIN2 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans ITGB1 ITGB5 FMOD ITGA2 LUM ITGAV ITGB6 HSPG2 BCAN DAG1 ITGA8 SERPINE1 LAMA1 COL9A1 SPARC COL9A3 DMP1 COL9A2 MUSK LAMC1 NCAN NCAM1 PTPRS BGN MATN1 MATN4 VCAN MATN3 TNXB DSPP TNC COMP IBSP TGFB1 TNN TNR VTN DCN ITGB3 HAPLN1 ITGAX LAMA5 ITGA2B LAMA3 ASPN ITGA7 ACAN LAMA2 LAMA4 LRP4 LAMB2 AGRN LAMB1 ITGA9 TGFB2 TGFB3 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis IGF2R NECAP1 TGFA COPS4 APOB COPS2 AVPR2 CD4 CHRM2 WNT5A ADRB2 GRK2 FZD4 M6PR CLTB SCARB2 ARRB2 AGFG1 EGF STON1-GTF2A1L KIAA0319 TOR1A EGFR TOR1B SYT9 SYT8 DAB2 IL7R CLTCL1 SNAP91 STON2 EPS15L1 SLC2A8 EPN1 SLC18A3 SGIP1 EPN2 VAMP4 FCHO1 FCHO2 UBQLN1 REPS2 AREG REPS1 UBQLN2 EPS15 NECAP2 SYT11 CFTR EREG BTC STAM HBEGF PICALM CLTC CLTA UBA52 AP2A1 AP2B1 CBL AP2A2 SYT1 VAMP2 AP2S1 SH3GL2 ITSN2 RPS27A TFRC UBB;UBC ITSN1 TF SH3GL3 SH3GL1 CD3D GRK3 CD3G VAMP3 GPS1 AGTR1 STAM2 HGS LRP2 TACR1 EPGN ARRB1 SYT2 LDLRAP1 COPS7B COPS7A VAMP7 VAMP8 SH3KBP1 TGOLN2 COPS3 COPS6 COPS5 AVP LDLR COPS8 DVL2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression PPP2R1B CDK1 PPP2R1A ARPP19 CCNB1 PPP2CB;PPP2CA ENSA MASTL PPP2R2A;PPP2R2D MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation FASTKD5 TBRG4 GRSF1 SUPV3L1 PNPT1 SLIRP REXO2 LRPPRC FASTKD2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors PTGER1 TBXA2R PTGDR PTGIR PTGER4 PTGER2 PTGER3 PTGFR PTGDR2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function LRAT RBP1 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis HSD3B1;HSD3B2 LHB CYP21A2 CYP11B1;CYP11B2 CGA INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria EPCAM UPK1A GBP2;GBP3;GBP1 HBD;HBB RPS27A GBP7;GBP4 CALM3;CALM1 UBB;UBC HBA2;HBA1 GBP6 UBE2D3;UBE2D2 CASP5;CASP4 UBA52 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development DPF1 DPF2 AIMP1 MARS1 DPF3 MARK3 AIMP2 AKT2 SMARCC1 AKT3 SMARCC2 EPRS1 RARS1 PPARGC1A CREBBP RAB27A IRF4 SS18L1 POMC SMARCA2 LARS1 CDC25B SMARCA4 LEF1 EEF1E1 SERPINE1 YWHAE SS18 ACTL6A PXDN MET ATP6V1E1 CDKN1A SIRT1 ATP6V1G1 YWHAG CTNNB1 BRCA1 TYRP1 TCF7 MYO5A CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GXYLT2 TERT SYTL2 PMEL EDIL3 MLANA TBX2 MLPH TCF7L1 ATP6V0D1 WNT3A YWHAB MC4R ATP6V1A HINT1 EDNRB PAX3 SOX2 TNFSF11 FOXD3 XPO1 ZIC1 EDN1 KIT EDN3 TFE3 MITF PXN SOX10 POU3F2 MC3R TFEC ALX3 YWHAZ TBX3 CSF1 ATP6V1C1 MC1R CCNB1 KARS1 MC5R CDK2 ID1 EP300 RPS6KA1 MAPK14 DARS1 PLK1 ZEB1 ATP6V0B ATP6V1B2 ATP6V0C BCL2 SNAI2 GMPR ITGA2 TYR ACTB-1 GSK3B CDH1 SOX9 UBE2I BCL7A STT3B QARS1 SIN3A BCL7C BCL7B ATP6V0E2;ATP6V0E1 MYRIP SUMO1 YWHAH BCL2A1 ARID1A TRPM1 ARID1B SMARCD1 SMARCD2 SMARCD3 HDAC1 DICER1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 USF1 TFEB AGO3;AGO1 TNRC6B CCND1 LIG1 ATP6V1H SMARCE1 TFAP2A DIAPH1 IARS1 BIRC7 GPR143 TCF7L2 MCM5 CDKN2A MCM2 CDH2 ASAH1 MAPK1 MAPK3 SMARCB1 DCT TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP10 FADD CFLAR CASP8 TNFSF10 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells EGF FGF10 FGF4 FGF2 FGF7 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants KREMEN1 KREMEN2 DKK1 DKK2 DKK4 LRP5 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS SOS1 BRMS1 TBK1 ITGB1 IFNGR1 RBX1 SUDS3 IFNGR2 IFNAR1 ATP1A4 RCOR1 ATP1A3 ATP1A2 ATP1A1 S1PR1 PTGES3-1 HMG20B ACE2 CHD4 CHD3 NCK1 ATP1B3-1 JAK2 FXYD2;FXYD6-FXYD2 ZBP1 NR3C1 IL1R1 HSP90AB1 REST CD79B ROCK2 CD79A FKBP1A CYSLTR1 SYK CRBN FNTA JAK1 ROCK1 CUL3 FKBP4 HDAC2 JAK3 HDAC1 TYK2 COMT MTA1 PDCD1 FNTB;CHURC1-FNTB NFE2L2 RBBP4 BRD4 SAP30L PLCG2 BLNK ATP1B2 TLR9 HSP90AA1 BTK ATP1B1 SAP18 RIPK1 TLR7 RBBP7 MTA2 MTA3 IMPDH1 IMPDH2 MBD3 IL6R AP2A1 AP2B1 KEAP1 AP2A2 KDM1A STAT2 ITGA4 GATAD2B FURIN AP2S1 GATAD2A ARID4B SH3KBP1 FXYD4 FXYD3 ARID4A SAP30 FXYD1 VAV1 FXYD6 PHF21A SIGMAR1 TUBB4A;TUBB;TUBB8B;TUBB8 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 SOS1 BUB1B-PAK6;PAK6 SOS2 PAK1 RAC1 PAK3 PAK5 ROBO1 PAK4 NCK2 SLIT2 NCK1 PAK2 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly FBP1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 G6PC1 H2BC21 PWWP2B CHD5 IKZF1 IKZF2 SUMO1 IKZF3 H2AC20 PHF6 MBD3L1 H2AB2;H2AB3;H2AB1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 ZNF687 TCF19 ZNF592 ZNF827 NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 HDAC2 NR2C2 HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC1 GATAD2B GATAD2A H2AC4 PCK1 H2AC14 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants CDC37 ERBB2 ERBIN HSP90AA1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 EIF5 RPL37A-1 RPL26L1 RPL4 RPL30 EIF5B RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2B1 EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance ALDOB NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes G6PD NFE2L2 MAFG TALDO1 PGD CREBBP EP300 TKT TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ERBB2 YY1 TGFA EGFR VEGFA ATAD2 TFAP2A CGA TFAP2C KIT ESR1 TFAP2E;TFAP2B BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 NCL-1 RPS13 RPS12 NOP56 RPL27A RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 PELP1 RPLP2 RPL36-1 RPL35A RPS27L CSNK1D RPS15A LTV1 RRP1 FTSJ3 RPS3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 DIS3 TEX10 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 EXOSC7 WDR12 EXOSC6 BYSL RPL18A EXOSC5 BOP1 FAU EXOSC4 TSR1 RPL12-1 MTREX EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TPTEP2-CSNK1E;CSNK1E RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X SNU13 EXOSC10 RPL35 RPL38 RPS3A C1D RPP30 MPHOSPH6 RPL39 DDX49 DDX47 RPP38 WDR3 FCF1 RPP21 RPP25 RPL21 WDR46 RPL23 WDR43 RPP14 RRP9 FBL RPL22 LOC102724159;PWP2 RPP40 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 RPL24 IMP3 RPL13A-1 WDR75 RPL27 IMP4 RPL26 DDX52 RPL29 UTP18 RPL28 DDX21 UTP25 HEATR1 RPL15-1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPL3L RPL5-1 DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 RPLP1-2 NOL11 RPL23A RPL11 RPL14 XRN2 RPL13 RPL18 RPL17 RPL19 RPS15 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling PTPN11 RAC1 MYO10 EZR UNC5A DCC ROBO1 UNC5B UNC5C PITPNA UNC5D PRKCQ NTN1 SLIT1 SLIT2 RGMB NCK1 RGMA DOCK1 PTK2 DSCAM SLIT3 WASL AGAP2 SRC HJV DSCAML1 TRIO CDC42 NTN4 ABLIM1 PLCG1 TRPC7 ABLIM2 NEO1 TRPC5 ABLIM3 TRPC6 TRPC3 SIAH2 TRPC4 SIAH1 TRPC1 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport TTPA MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants FLT3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding PFDN6 TUBAL3 GBA GNA14 AP3M1 GNG10 STAT3 GNA15 GNG2 GNG5 GNG4 CSNK2A1;CSNK2A3 GNA11 GNG8 CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 NOP56 ARFGEF2 GNG13 CCT6A GNAQ GNB2 GNB1 PDCL GNB4 GNB3 SKIV2L FBXL3 GNB5 RGS11 FBXL5 TUBA8 WRAP53 TP53 HDAC3 TUBA1A CSNK2A2 CSNK2B TUBA4A DCAF7 CCT6B PFDN4-1 GNGT1 TUBA1C KIF13A TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 CCT3 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS PFDN1 TUBB4B PFDN2 FKBP9 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells MPO LPO FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate WNT3A SOX1 ZEB2 OTX2 SOX2 POU3F1 ZNF521 TBX6 FGF8 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER ISY1;ISY1-RAB43 RBX1 CDK7 MNAT1 POLR2A POLR2B POLD1 POLR2C POLR2D POLR2G ZNF830 POLR2I RFC5 TCEA1 RFC3 RFC4 RFC2 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 LIG1 POLR2F POLR2H POLK POLE POLR2L RFC1 LIG3 ERCC3 PCNA UBA52 PPIE ERCC2 DDB1 GTF2H1 GTF2H3 ERCC6 GTF2H4 RPA1 RPA2 AQR POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 PRPF19 POLD2 RPA3 RPS27A XRCC1 POLE4 CUL4A UBB;UBC POLE2 POLE3 CCNH CUL4B USP7 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions SCN1A SPTBN2 ITGB1 ANK2 SHTN1 KCNQ2 KCNQ3 CNTN6 CHL1 ITGA2 CSNK2A1;CSNK2A3 SPTBN4 PAK1 ITGA10 ITGAV ANK1 SPTBN5 NUMB SCN3B SCN3A CD24 SCN2A SCN2B NRP2 SCN9A SDCBP NRCAM SCN8A CNTN1 SPTA1 SCN5A GAP43 DCX SCN4A SCN4B LAMA1 DLG1 ANK3 SCN7A NRP1 EGFR LAMC1 NCAN NCAM1 CNTN2 CSNK2A2 RANBP9 RAC1 EZR CSNK2B RPS6KA6 ITGB3 SPTBN1 CLTC CLTA AP2A1 DPYSL2 AP2B1 RDX AP2A2 DLG3 DLG4 DNM1 ITGA1 DNM2 MSN ITGA2B DNM3 AP2S1 ALCAM SCN11A SH3GL2 SCN10A ITGA5 SPTAN1 L1CAM KIF4B;KIF4A LYPLA2 LAMB1 RPS6KA3 CNTNAP1 RPS6KA5 RPS6KA2 SPTB RPS6KA1 ITGA9 MAP2K2;MAP2K1 HSPA8 VAV2 MAPK1 MAPK3 NFASC RPS6KA4 EPHB2 SCN1B DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME ADAL ABCC5 PNP-1 GMPS ADH1C;ADH1B;ADH1A GSTT1 TPMT PON3 SULT2A1-4 PON1 GSTA3;GSTA5;GSTA1;GSTA2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 BSG NT5C2 BCHE GUK1 NME2 SLCO1A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 NME1 SLC28A2 ABCB1 SLC29A1 ALB UGT2A1 SLC29A3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC29A2 SLC28A3 HSD11B1 HSD11B2 XDH UGT1A1;UGT1A6 HPRT1 GLYATL3 CNDP2 SLC22A2 ACSM2A;ACSM2B RAC1 SLC22A1 GGT1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 IMPDH1 IMPDH2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG2 CYP2E1 ADA ITPA ADK SERPINA6 GSTA3;GSTA1 ACSM5 GGT5 ACSM4 GGT7 GGT6 GSTP1 SLC16A1 ABCC4 VAV3 GLYAT SLC22A3 CES2 SLC22A8 CES1 VAV1 VAV2 PCK1 NAT1 GSTM1;GSTM2-1 ACY1;ABHD14A-ACY1 NUDT15 ABCC3 ABCC1 ABCC2 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUP133 DYNC1LI1 DYNC1LI2 KIF18A BUB1 NDC80 RANGAP1 CLASP2 CENPN-2 MIS12-1 BUB1B CDCA8 CDC20 SKA1 PPP1CC SKA2 BUB3 MAD2L1 DYNC1I1 SPDL1 NUP43 B9D2 SPC24 SPC25 RANBP2 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP NSL1 RPS27 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 NUP37 SGO2 AURKB CENPS-CORT;CORT;CENPS MAPRE1-1 PPP2R1A CENPT NUP107 CENPU KNL1 ZW10 CENPF CENPH CENPI TAOK1 DSN1 CENPK CENPL CKAP5 CENPM RCC2 ZWINT XPO1 CENPO NUP160 CENPP AHCTF1 PAFAH1B1 NUP85 CENPQ DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E CLIP1 MAD1L1 DYNC1H1 NDE1 ITGB3BP PLK1 SEC13 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding PFDN6 TUBAL3 TUBA1A CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 CCT6A TUBA4A CCT6B PFDN4-1 TUBA1C TUBB1 TUBA8 CCT3 CCT2 TUBB2B;TUBB2A VBP1 TCP1 TUBB4B PFDN1 PFDN2 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression TAF1D SIRT1 TAF1B H2AC20 TBP TAF1C H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SUV39H1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 RRP8 H2BC1 H2AC14 H2BC21 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer CBL GAB1 SOS1 PIK3CA AREG TGFA HSP90AA1 RPS27A EREG BTC UBB;UBC EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 HBEGF EPGN NRAS UBA52 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT1 PIK3CA LCK STAT5A STAT3 PIK3R3 STAT5B YES1 PIK3R2 HRAS PIK3R1 FYN JAK2 LYN KIT NRAS CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic ESCO1 BUB1 FBXL18 ESCO2 CLASP2 AKT2 AKT3 CSNK2A1;CSNK2A3 PPP1CC GOLGA2 CDC25A HMMR CDC25B PRIM2 PRIM1 POLA1 POLA2 RPS27 LPIN1 LPIN2 LPIN3 SKP2 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PPP1CB MAPRE1-1 PRKACA-1 ACTR1A TUBA1A LBR PPP2R1A CNTRL CEP250 NEK2 BTRC CEP290 YWHAG RAB8A SKP1 CDK5RAP2 HSP90AA1 OPTN-1 HJURP CEP135 PPP1R12A MIS18BP1 BORA FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 KIF20A CEP192 RPS27A PCNT CEP76 OBI1 LCMT1 CLASP1 UBB;UBC PPME1 CEP78 TICRR PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 KIF18A IST1 SPAST CC2D1B DHFR2;DHFR JAK2 KIF23 HSP90AB1 TYMS KIF2A KIF2C KIF2B CABLES1 CENPE WEE1 MAX LMNB1 PPP2R2A;PPP2R2D TUBA1C TUBB1 E2F5 E2F6 TUBB2B;TUBB2A CCNE2 CCNE1 RB1 CCNH H2AC14 TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCND3 CCND2 CDKN2D CDKN2C TUBA8 H2AC20 H2AB2;H2AB3;H2AB1 MYBL2 DNA2 E2F4-1 TFDP1 TFDP2 RAB1A RAB1B E2F1 CDC7 E2F3 TPX2 CDKN1A CDKN1B H2AJ CDCA5 PDS5B PDS5A WAPL ESPL1 CDKN2B H2BC5 PCNA H2BC1 RPA1 PTK6 RPA2 CDK4 CDK2 PTTG1;PTTG2 RPA3 EP300 PHLDA1 H2AC4 KMT5A CDK11A;CDK11B CDC25C CDK6 ABL1 CDK7 MNAT1 GSK3B KPNB1 H2BC21 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 RBL2 RBL1 BIRC5 SMC3 AURKB RAD21 STAG1 HDAC1 STAG2 SMC1A RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLE RFC1 LIN54 LIN37 H2BC15;H2BC3;H2BC11;H2BC12 LIN9 LIN52 LYN GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 POLD3 GINS4 MCM3 POLD4 MCM4 POLD2 MCM5 MCM6 MCM2 POLE4 MAPK1 POLE2 POLE3 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 C1orf112 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 XPO1 AKT1 TNPO1 NUP214 PRKCA ANKLE2 SET-1 MCM10 DBF4 PRKCB DYNC1LI1 DYNC1LI2 RBX1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 GTSE1 FKBPL NUF2 EMD NUDC INCENP CENPA CENPC E2F2 CENPT TOP2A NUP107 CENPU NUP188 RCC1 BANF1 NUP210 CENPF CENPH LIG1 GORASP1 CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A CENPL NUP205 USO1 CENPM NEK9 NEK6 AAAS NEK7 CENPO CENPP NUP160 NUP85 CENPQ TPR NUP88 NUP155 NUP153 CHMP2B CHMP2A RRM2-1 CLIP1 FEN1 MAD1L1 NUP62 CDKN1C NDC1 SEC13 NUP133 NDC80 RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 NUMA1 CHMP7 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 VPS4A TUBGCP4 SPDL1 NUP42 NUP43 RAE1 RANBP2 NSL1 NUP35 RAN NUP37 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KNL1 ZW10 DSN1 EML4 RCC2 ZWINT CDC14A AHCTF1 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E FOXM1 VRK1 LEMD2 CTDNEP1 CNEP1R1 FBXL7 RAB2A GORASP2 BLZF1 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 UBE2I DYRK1A POLD1 CKS1B PPP2R3B B9D2 SPC24 SPC25 PKMYT1 ERCC6L ARPP19 NCAPH2 SUMO1 NCAPG2 ZWILCH NIPBL ENSA SIRT2 NCAPD3 PMF1;PMF1-BGLAP MAU2 MASTL MCPH1 TP53 KNTC1 SGO1 SGO2 MYC CENPS-CORT;CORT;CENPS CSNK2A2 CCND1 CSNK2B ANAPC15 ANAPC16 TK1 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA NCBP1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 NUP35 NUP62 NUP37 NDC1 SEC13 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F2 KLKB1 F12 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ-1 KHDRBS1 KHDRBS2 KHDRBS3 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) FRS2 TIAM1 BDNF GAB1 SOS1 PIK3CA CDK5R1 PTPN11 NTF3 SRC RAC1 DOCK3 CDK5 GRIN2B PLCG1 HRAS PIK3R1 FRS3 NRAS NTRK2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components LIMS4;LIMS1 PARVA TESK1 ARHGEF6 ACTN1 RSU1 PARVB PXN HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) BLM RAD51 POLD1 RAD9B KAT5 POLH CHEK1 RAD51B RAD9A RAD51C HUS1 EXO1 MUS81 C1orf112 EME1-1 BRCA2 TOPBP1 DNA2 RAD51AP1 RHNO1 SLX4 EME2 RFC5 RFC3 FIGNL1 GEN1 RFC4 XRCC2 RFC2 XRCC3 PALB2 SPIDR SLX1A;SLX1B ATRIP BARD1 RBBP8 SEM1 RAD17 ATM RAD50 ATR BRCA1 POLK POLE RMI2 RFC1 RMI1 TOP3A RAD51D PCNA UBA52 WRN RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 RPS27A RAD1 POLE4 UBB;UBC BRIP1 MRE11 POLE2 POLE3 NBN RTEL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes LPL MED30 PDK4 ABL1 MED1 ACSL1 CDK8 MGLL MED4 CDK5 MED6 MED7 AGPAT2 PAXIP1 PEX11A CCNC-1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PAGR1 PPARGC1B CREBBP H2BC21 CIDEC WDR5 RXRA KDM6A GPAM H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 LPIN1 ASH2L MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 CEBPA NCOA1 NCOA2 ACSS3 NCOA6 ELOVL5 NCOA3 HDAC3 DGAT2 MED27 SIRT1 MED23 NCOR2 RBBP5 H2AJ NR5A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 AJUBA SCD H2BC1 THRSP FABP4 MED31-1 EP300 PHLDA1 H2AC4 ADIPOQ TBL1XR1 RB1 KMT2D KMT2C LIPE H2AC14 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling SOS1 PIK3CA PTPN11 PTPN6 PIK3R3 IL3RA IL2RB GAB2 INPPL1 CSF2RB BLNK CSF2RA INPP5D IL5RA YES1 SHC1-1 CRK JAK2 LYN CBL CSF2 YWHAZ STAT5A IL2 STAT5B IL3 PIK3CD SYK PIK3R2 HCK PIK3CB IL5 VAV1 RAPGEF1 IL2RA PIK3R1 IL2RG FYN JAK1 CRKL PRKACA-1 JAK3 TEC SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling SOS1 EREG BTC EGF SHC1-1 AREG TGFA HRAS EGFR HBEGF EPGN NRAS LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production LRRFIP1 CTNNB1 CREBBP IRF3 EP300 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle ABL2 SRGAP3 SOS1 SRGAP2 GNA13 SRGAP1 PIK3R3 NOXA1 FMNL1 RASGRF2 SNAP23 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 WASL SOS2 PARD6A IQGAP1 SH3BP1 NHS WASF2 WASF3 ARHGAP5 ARHGAP21 BAIAP2 CDC42BPA DOCK7 LBR BAIAP2L1 OPHN1 TMPO ARHGAP35 LEMD3 SPATA13 RAC1 KTN1 NISCH VANGL1 ARAP1 DEPDC1B GARRE1 KALRN DOCK1 EPHA2 DOCK10 DOCK11 CYFIP2 CYFIP1 GIT1 NCKAP1 VAV3 WASF1-1 TRIO RALBP1-1 TFRC WIPF1 LAMTOR1 WIPF2 WIPF3 ERBIN VAV1 VAV2 TIAM2 PREX2 PREX1 ARHGEF4 RACGAP1 BCR ARHGEF7 ARHGEF5 ITGB1 ARHGEF6 AMIGO2 NGEF WAS NOXO1 DOCK6 IQGAP2 DOCK5 PAK1 IQGAP3 DOCK4 DOCK3 DOCK9 DOCK8 ABR PAK3 PAK5 NCKAP1L PAK4 GIT2 MCAM CAV1 NOX3 MYO9B FERMT2 MPP7 NOX1 DLC1 ARHGAP9 JAG1 ESYT1 ARHGAP1 ARHGAP4 EMD BUB1B-PAK6;PAK6 GMIP ARHGAP39 CIT DOCK2 ARHGAP44 SYDE2 CDC42EP4 CDC42 ARHGAP42 CDC42EP1 ARHGDIA VAMP3 ARHGDIB PIK3R2 CYBB CYBA PIK3R1 ARHGAP45 FGD5 CHN2 ARHGEF25 CHN1 PIK3CA YKT6 ARHGAP17 ARHGAP15 FARP2 FARP1 ARHGAP12 ARHGAP22 ARHGAP20 MCF2 DEF6 ECT2 ARHGEF39 ABI2 ARHGAP29 TAOK3 ARHGAP27 RAB7A ARHGAP26 ARHGAP25 ABI1 ARHGAP24 ARHGAP23 ARHGAP33 PLD1 ARHGAP32 PKN2 ARHGAP31 PKN1 PLD2 ARHGAP30 PAK2 DIAPH3 TIAM1 NCF1 FAM13B NCF2 NCF4 FAM13A MCF2L ARHGEF11 ARHGEF10 SWAP70 ARHGEF15 VRK2 ARAP2 ARHGEF19 ARHGEF18 ARAP3 ARHGAP10 ALS2 SLC1A5 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping JUN WNT5A CYBA NOXO1 MAPK8 DVL1 RAC1 NOX1 NOXA1 FZD7 DVL2 DVL3 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO GRK2 SMO SHH BOC GAS1 ARRB2 CDON EVC2 EFCAB7 EVC GAS8 DHH KIF3A IHH CSNK1A1 PTCH1 ARRB1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins LOC100509620;LOC112267859;AQP7 AQP9 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis MUC17 ST3GAL4 ST6GALNAC2 MUC5B MUC20 ST3GAL1 ST3GAL2 MUC21 ST3GAL3 MUC12 MUC15 MUC3A MUC5AC ST6GAL1 ST6GALNAC3 ST6GALNAC4 MUC1 MUC2 MUC7 MUC4 MUC6 MUC13 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions SNRPD2 SNRPD1 ELAVL2 SNRPD3 VIM ATG14 SDC4 H2BC18 SDC2 SDC3 PIK3R4 SNRPE-2 SDC1 IKBKE PTBP1 HNRNPH1 HNRNPA1-1 HNRNPM NEK2 CTNNB1 APOA1 HSP90AA1 CDC73 LEO1 GPC1 GPC3 RBMX ELAVL1 GPC2 GPC5 GPC4 GPC6 STAT2 TJP1 STING1 AGRN HSPA8 SNRPF SNRPB DDX5 MAVS HNRNPC HSPG2 HSP90AB1 CPSF2-1 MBL2-1 PIK3C3 NUDT21 BECN1 FUS SNRPG-2 BCAS2 C1S HNRNPA0 HNRNPA3 NFKBIB GPKOW CDC5L DHX9 GTF2F1 GTF2F2 SUGP1 TAOK1 PABPN1-1 MMP9 PEX19 PPIE HNRNPF HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 HNRNPU HNRNPR SNRPA1 WDR61 HNRNPL HNRNPK HNRNPD RPL18 WDR33 H2AC14 ISY1;ISY1-RAB43 PDCD6IP NCBP1 PHF5A AUP1 PAPOLA TXNL4A SNRPN PLRG1 DNAJC8 POLR2A FIP1L1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 PPIL6 SRRM2 POLR2G COG1 POLR2I CRNKL1 DAXX CSTF3 CSTF2 H2AC20 NCBP2-1 HNRNPH2 MAPKAP1 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 CPSF4 CPSF1 SNW1 CPSF3 CWC15 CGAS RBM5 RPTOR TAL1 C4BPA C4BPB IFIH1 LOC110384692;C4A;C4B_2;C4B TRIM25 EXOC1 SF3B1 GRPEL1 H2BC5 GBF1 H2BC1 RICTOR PQBP1 SRRT NRBP1 SNRNP200 H2AC4 FASN CTNNBL1 PRCC CCAR1 U2AF1L5;U2AF1 EIF4A3 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK CDC40 RBM10 PAF1 SRRM1 RETREG1 DHX15 DHX16 SRSF2 SRSF3 UBE2I SRSF5 SRSF6 SRSF7 SRSF9 WBP11 HNRNPUL1 H2BC21 SRSF1 U2AF2 PRR5 DDX46 DHX38 DDX42 SRSF11 RBM17 DYNLT1 SRSF4-1 BUD31 ALYREF RBM22 MLST8 RNPS1 DDX23 CSTF2T SMNDC1 U2SURP CLP1 YBX1 CAMK2B CAMK2D CAMK2A UBR4 CAMK2G MTOR SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 LY96 DDX3X-1 SF3A3 SF3A1 SF3A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 XAB2 POLR2E RIPK1 CPSF7 CLEC5A POLR2F POLR2H VTN TLR4 POLR2L CHERP H2BC15;H2BC3;H2BC11;H2BC12 NFKBIA F2 PUF60 SNRPB2 AQR CLU PRPF19 PCF11 H2AC16;H2AC11 EFTUD2 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation S100A12 N4BP1 USP18;USP41 NFKBIB SAA2;SAA1 UBE2V1 NKIRAS1 NKIRAS2 IKBIP TRAF2 CHUK LRRC14 CASP8 USP14 IRAK1 IRAK2 NLRC5 TIFA HMGB1-1 IKBKB IKBKG UBE2N TAB3 TAB2 NFKBIA UBA52 TAB1 APP RELA NFKB2 RPS27A TRAF6 UBB;UBC NFKB1 TP53 MAP3K7 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer IL10RA PRF1 GCC2 GZMH;GZMB-1 RBX1 MDM2-2 STAT3 NPM1-2 STRN PRKAR1A MCL1 SEC31A MYH9 SQSTM1 IRF4 VCL RANBP2 STAT5A HIP1 BCL2A1 DCTN1 FN1 PPFIBP1 RRBP1 ALK IRS1 LMO7 TP53 PIK3R2 PIK3CB JUNB PLCG1 PIK3R1 CARS1 FRS2 HDAC1 JUN TYK2 PIK3CA PTPN6 TNRC6C MOV10 CDKN1A ATIC AGO4 AGO2 SKP1 EEF1G AGO3;AGO1 EIF2AK3 GRB2 IL22 EML4 CLTC UBA52 IL10 TPR CEBPB STAT1 MSN CUL1 KIF5B CCNB1 WDCP TPM4 BCL11A TPM3 RNF213-2 RPS27A TFG UBB;UBC ZC3HC1 FOXM1 ZAP70 KLC1 MAPK1 ICOS RB1 MAPK3 RPS6 MAPK9 FRS3 PPM1B DNMT1 MAPK8 BIRC6 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases JUN PPP2R1A MAPK7 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 FOS ATF2 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MAPK1 MAPK14 MAPK3 MEF2C MAPK11 MAPK9 MAPK8 MAPK10 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription RUNX3 TEAD1 TEAD2 TEAD3 YAP1-1 TEAD4 WWTR1 CCN2 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle ADD3 DBN1 PGRMC2 SLC4A7 PLXNB1 PAK5 CAPZB EFHD2 MCAM CAV1 ESYT1 ARHGAP1 EMD BUB1B-PAK6;PAK6 ARHGAP39 VAMP3 PIK3R2 PIK3R1 WHAMM LMAN1 ARHGAP5 ARHGAP21 CPNE8 LBR ARHGAP17 TOR1AIP1 ARHGAP12 TMPO ACTN1 ARHGAP35 LEMD3 VANGL1 DEPDC1B RAB7A ARHGAP26 LMNB1 DIAPH1 FILIP1 ARHGAP32 VAPB DIAPH3 AKAP12 HINT2 STBD1 VRK2 RHOD STEAP3 ANKFY1 RACGAP1 MOSPD2 PLXNA1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling WASL SRC RAC1 TRIO CDC42 DCC ABLIM1 NTN1 ABLIM2 ABLIM3 DOCK1 NCK1 PTK2 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R7 TAS2R8 TAS2R3-1 GRM4 SCN3A SCN2A TAS2R1 SCN2B TAS2R4 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GRM1 CALHM1 TAS2R16 CALHM3 GNG13 SCN9A GNB1 TAS2R40 GNB3 TAS2R41 ITPR3 PRH1-TAS2R14;TAS2R14-3 TAS1R2 TAS1R1 TAS2R39 TAS1R3 GNAT3 TRPM5 PLCB2 SCN4B TRPM4 SCN1B DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) CP SLC40A1 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements TRIM28 DPF1 TASOR DPF2 DPF3 ZNF324B;ZNF324 MORC2 SMARCC1 SMARCC2 CBX5 ACTB-1 PIWIL4 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 DNMT3L BCL7A ZNF382 SETDB1 SS18L1 H2BC21 BCL7C ZNF649 BCL7B SMARCA2 SMARCA4 RBM7 H2AC20 SUMO2 ZNF30 H2AB2;H2AB3;H2AB1 DNMT3A H2AZ2;H2AZ1 ARID1A ARID1B ZNF264;ZNF805-1 C19orf84 SMARCD1 SMARCD2 SS18 HDAC2 SMARCD3 ACTL6A HDAC1 PPHLN1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 SMARCE1 ATF7IP MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 ZNF669;ZNF670 GATAD2B GATAD2A MPHOSPH8 ZNF331 MTREX H2AC4 SPOCD1 ZNF317 ZNF354A;ZNF354B-4 SMARCB1 ZCCHC8 EHMT2 EHMT1 H2AC14 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation FGF20 FGF23 FGF1 FGF4 FGF16 FGF9 FGF2 GALNT3 FGF18 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 MPG OGG1 H2AC14 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RPS14 ABL2 SRGAP3 NCBP1 SOS1 RPS17 SRGAP2 SRGAP1 RPS16 RPS19 CLASP2 MSI1 RPS18 HOXA2 ISL1 COL4A5 RPS11 GSPT2 RPL10A GSPT1 RPS10 LHX3 LHX2 RPS13 LHX4 RPS12 LHX9 USP33 ROBO1 UPF2 ETF1 CAP1 CXCR4 ZSWIM8 NCK2 SLIT1 NCK1 CAP2 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 EVL PFN2-1 PSMA7 SOS2 PSMD8 LDB1 SRC PSMB6 RPL10;RPL10L-1 PSMB7 NCBP2-1 PSMD6 RPS25 RPS27 PSMB4 PSMD7 RPS29 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PPP3CB NRP1 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKACA-1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RAC1 PFN1 RPLP2 RPL36-1 RHOA RPL35A RPS27L RPS15A GPC1 RPS3 UBA52 NELL2 SLIT3 RPS2 PRKCA RPL18A FAU RPL12-1 RPS27A CLASP1 UBB;UBC RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA ABL1 FLRT3 RBX1 ROBO2 EIF4A3 CASC3 RPL22L1 PAK1 RPL37A-1 PAK3 RPL26L1 DCC PAK5 PAK4 RPL4 RPL30 NTN1 RPL3 RPL32 SLIT2 MYO9B RPL31 PRKACB-1 RPL34 PRKAR2A RPL8 RBM8A RPL9 RPL6 RPL7 RPS4X MAGOH;MAGOHB RPL35 BUB1B-PAK6;PAK6 RPL38 VASP RPS3A ARHGAP39 UPF3B DAG1 RNPS1 ENAH RPL39 CDC42 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 AKAP5 CXCL12 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 PAK2 RPL23A ELOC-1 RPL11 RPL14 ELOB RPL13 RPL18 RPL17 RPL19 RPS15 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) MSH2 PMS2 MLH1 MSH6 MSH3 PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway SHPK PRPS2 PRPS1 TALDO1 DERA TKT RPIA G6PD PGM2 PGLS PGD RPE;RPEL1 RBKS TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling TBK1 ULK1 TNF TAB3 TAB2 TAB1 ADAM17 TAX1BP1 IKBKE RNF31 XIAP OTUD7B SPATA2 TNFAIP3 SMPD3 SHARPIN USP21 SMPD2 USP4 RACK1 MIB2 UBE2D3-1 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 CHUK BIRC3 CASP8 OPTN-1 RIPK1 FADD BAG4 IKBKB IKBKG UBE2D3;UBE2D2 UBA52 TRAF1 UBE2D1 MAPKAPK2 RPS27A UBB;UBC MAP3K7 SPPL2B SPPL2A CLIP3 STUB1 NSMAF OTULIN USP2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events NCBP1 EAF1 EAF2 CTR9 RTF1 CDK7 GTF2A1 GTF2A2 CTDP1 PAF1 MNAT1 TAF9 POLR2A SUPT6H POLR2B POLR2C POLR2D AFF4 POLR2G TAF9B POLR2I MLLT1 TAF15 MLLT3 IWS1 TAF12 TBP TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 GTF2B CDC73 SUPT16H POLR2E LEO1 POLR2F GTF2F1 POLR2H GTF2F2 POLR2L GTF2E1 ERCC3 GTF2E2 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B ELL ELOC-1 TAF7L WDR61 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A NEK2 BUB1B CDC20 BUB3 MAD2L1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 RPS27A ANAPC7 UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 SRGAP3 SRGAP2 SRGAP1 ROBO1 SLIT2 ARHGAP39 RAC1 CDC42 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora EPM2A PPP1R3C UBB;UBC GYG1 GYS1 NHLRC1 RPS27A UBA52 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription NOTCH1 HES1 SNW1 SMAD2;SMAD3 MAMLD1 RBPJ KAT2B KAT2A MAML2 ACTA2 EP300 MAML1 HES5 FLT4 MAML3 NOTCH2 NOTCH4 HEY1 CREBBP HEY2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions PDGFB ITGB1 ITGB5 ITGA2 ITGAV FGF2 TRAPPC4 SDC4 SDC2 SDC3 HSPG2 DAG1 ITGB4 SDC1 LAMA1 DTNA LAMC2 DTNB LAMC1 SSPN DDR1 THBS1 DDR2 PDGFA DRP2 DMD ACTN1 TNC ITGA6 TGFB1 UTRN VTN TTR ITGB3 CASK LAMC3 SGCE SGCD SGCA SGCB LAMA5 SGCG SNTA1 PRKCA LAMA3 NRXN1;NRXN3;NRXN2 LAMA2 LAMA4 LAMB3 LAMB2 AGRN SGCZ LAMB1 SNTB1 SNTB2 NTN4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation ABL1 ARPC4 ARPC5 WAS ARPC2 LIMK1 ARPC3 PAK1 NF2 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A HSP90AB1 WASL ACTG1 CD3G CDC42 SYK FCGR3A;FCGR3B WASF2 FCGR1A WASF3 BAIAP2 NCKIPSD RAC1 MYO10 HSP90AA1 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK CFL1 DOCK1 PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling UBE2V1 INPP5D CD4 TRAT1 UBE2N TAB2 PSMD12 PSMD11 PSMD14 LCK PSMD13 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D PSMA7 HLA-DPA1 PDPK1 PSMD8 PTEN HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PSMB6 PSMB7 CD3G PSMD6 HLA-DRA PSMB4 PSMD7 TRAF6 PSMB5 PSMB2 PSMB3 PSMD2 PIK3R2 PIK3CB PSMD3 PSMB1 PSMD1 PIK3R1 ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PIK3CA PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 CDC34 IKBKB PRKCQ CARD11 BCL10 IKBKG MALT1 UBE2D3;UBE2D2 UBA52 NFKBIA CUL1 UBE2D1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs MYL6 PPP1R12B ROCK2 LIMK2 LIMK1 MYH14 PAK1 MYH11 MYH10 PPP1R12A RHOA RHOC MYL12B RHOB CFL1 ROCK1 MYH9 PPP1CB SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription EGR1 SNAI1 SNAI2 SLC38A9 RCOR1 ATN1 BMI1 SALL4 MAF1 MECOM CHD4 RING1 RHEB CHD3 ATF2 HDAC5 RNF2 HDAC7 REST CBX8 RRAGA RRAGC CBX6 EED RRAGB PHC2 MLST8 PHC1 RRAGD PPARG EZH2 CBX4 CBX2 PHC3 TP53 NR2E1 HDAC2 HDAC3 HDAC1 JUN MTOR MTA1 RBBP4 RPTOR RBBP7 MTA2 MTA3 MBD3 SUZ12 KDM1A GATAD2B GATAD2A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 MAPK1 MAPK3 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling FGF20 FRS2 PPP2R1A FGF23 PTPN11 FGF2 KLB FGF19 FGFR4 UBA52 CBL PPP2CB;PPP2CA RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FGF6 MKNK1 FGF4 SPRY2 FGF16 FGF9 FGF18 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA2-1 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRND CHRNA5 CHRNA4 CHRNA6 CHRNG CHRNE LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling ABCA1 ABCG5 NR1H3 TNRC6C MOV10 FABP6 APOC1 TNRC6A-1 NRIP1 APOC4 AGO4 AGO2 NCOR2 AGO3;AGO1 TNRC6B NCOR1 ANGPTL3 PLIN1 GPS2 KDM3A NR1H2 KDM4A SCD APOC2 KDM1A RXRA APOD MYLIP EP300 KDM1B CETP ARL4C TBL1XR1 EEPD1 FASN ABCG1 RXRB APOE PCK1 NCOA1 HDAC3 ABCG8 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs FRS2 SOS1 KIDINS220 SHC1-1 YWHAB CRK SHC2 RALGDS NTRK1 RALB MAPK13 RIT1 RIT2 NGF RALA-1 MAPKAPK2 SHC3 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 HRAS MAPK14 BRAF MAPK3 MAPK11 CRKL MAPK12 MAPKAPK3 NRAS EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins NGF PCSK6 FURIN PCSK5 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE GPCPD1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) RAD17 ATM ABL1 RAD50 ATR BLM BRCA1 LIG1 RAD52 RMI2 RAD51 RMI1 TOP3A WRN RAD9B KAT5 RAD9A RPA1 HUS1 RPA2 EXO1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 RFC2 BRIP1 ERCC4 MRE11 ATRIP ERCC1 NBN BARD1 RBBP8 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria BMF MAPK8 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis MRC1 LTF TLR2 CTSG SFPQ-1 KPNA1 B2M PGK1 NOS2 HGS ATP6V1H CORO1A RAB7A KPNB1 ENO1 DUSP16 UBA52 GSK3A TRIM27 RPS27A RNF213-2 UBB;UBC RAB5A MAPK1 MAPK3 VPS33B TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation IFNB1-4 TBK1 TANK TRAF2 SIKE1 IRF3 EP300 DDX58 TRAF6 IRF7 RNF135 IFIH1 TRIM25 IKBKE MAVS CREBBP COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin PDS5A STAG2 WAPL SMC1A NIPBL SMC3 MAU2 RAD21 STAG1 PDS5B MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility DOCK7 GAB1 MET ITGB1 ITGA2 RAC1 CRK LAMC3 PTK2 LAMA5 LAMA3 ITGA3 LAMA2 SRC LAMA4 LAMB3 LAMB2 LAMB1 LAMA1 RAP1A RAPGEF1 CRKL LAMC2 LAMC1 TNS4 RAP1B TNS3 HGF METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins LPL AKR1B15;AKR1B10 TTPA APOB APOA2 VKORC1L1 APOA1 APOA4 PNLIP LRP1 TTR LRAT BCO2 LRP2 BCO1 GPC1 LRP8 SDC4 GPC3 APOC3 SDC2 GPC2 RBP4 SDC3 GPC5 RBP2 GPC4 RBP1 HSPG2 APOC2 GPC6 UBIAD1 RETSAT LRP10 RDH11 AGRN LRP12 SDC1 VKORC1 APOM LDLR PLB1 APOE CLPS GPIHBP1 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle SLC25A12 SLC25A22 SLC25A11 GOT2-1 GOT1-1 SLC25A13 MDH1 MDH2 SLC25A18 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD8 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle SRGAP1 STOM FMNL3 ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP PLEKHG3 PLEKHG4 PLEKHG6 ROCK2 IQGAP1 ROCK1 ARHGAP5 PCDH7 ARHGAP21 FLOT2 LBR OPHN1 TMPO PLEKHG5 ARHGAP35 KTN1 VANGL1 ARAP1 TMEM87A RHOA DEPDC1B KALRN SCFD1 NET1 VAPB ANLN FAF2 AKAP13 C1QBP STBD1 VAV3 CCDC115 TRIO TFRC ERBIN VAV1 VAV2 PREX2 PREX1 ARHGEF3 ARHGEF4 RACGAP1 ARHGEF1 STARD8 ARHGEF2 BCR ARHGEF7 ARHGEF5 DAAM1 NGEF IQGAP3 PGRMC2 EMC3 ABR STARD13 BCAP31 JUP MCAM CAVIN1 CAV1 MYO9B MYO9A ACBD5-1 DLC1 ARHGAP9 ARHGAP1 ARHGAP6 TJP2 ARHGAP4 RTKN GMIP ARHGAP39 CIT DOCK2 ARHGAP44 ARHGAP42 ARHGDIA VAMP3 ARHGDIB PIK3R2 PKN3 ARHGEF40 PIK3R1 ARHGAP45 LMAN1 ARHGEF25 ARHGEF28 ARHGAP19 STX5 ARHGAP18 YKT6 FARP1 ARHGAP22 ARHGAP20 MCF2 HMOX2 DEF6 RHPN2 ECT2 ARHGAP29 MACO1 ARHGAP28 ARHGAP26 ARHGAP24 ARHGAP23 DIAPH1 PLD1 AAAS ARHGAP32 PKN2 ARHGAP31 PKN1 ARHGAP30 DIAPH3 TIAM1 SOWAHC ARHGEF10L FAM13A MCF2L STK10 FLOT1 SLK ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 TEX2 ARAP2 ARHGEF19 ARHGEF18 ARAP3 ARHGAP10 DDRGK1 ARHGAP11A-1 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ACTL6A CSNK2A2 SMARCC1 SMARCC2 CSNK2A1;CSNK2A3 CBFB CSNK2B BMI1 RUNX1 SMARCE1 RING1 PCGF5 PBRM1 RYBP RNF2 YAF2 ACTL6B SMARCA2 SMARCA4 CBX8 AUTS2 CBX6 PHC2 PHC1 HIPK2 CBX4 ARID1A EP300 CBX2 ARID1B PHC3 SMARCD1 SMARCB1 SMARCD2 ARID2 SMARCD3 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs MYL6 KLK3;KLK2 KDM4C-1 YWHAG MYH14 PAK1 MYH11 RAC1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYH10 PPP1R12A RHOA MYL12B YWHAB H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 MYH9 PKN2 H2BC5 PKN1 H2BC21 H2BC1 KDM1A SFN YWHAZ AR YWHAQ PPP1R12B YWHAH H2AC20 PDPK1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 PKN3 RHOC YWHAE RHOB PPP1R14A NCOA2 PPP1CB H2AC14 CDC25C LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization HSD17B13 CIDEC CIDEA FITM1 FITM2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R1 CYB5R4 CYB5RL HBA2;HBA1 CA1 AQP1 CA2 CA4 HBD;HBB CYB5R2 RHAG SLC4A1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling FLNA GP1BA GP5 GP9 YWHAZ RAF1 PIK3R1 VWF GP1BB CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall SOS1 EPCAM APOB SELL JCHAIN YES1 SLC7A6 GP6 SLC7A7 SLC7A8 SLC7A9 CD84 SDC4 SDC2 SDC3 ITGB2 FCER1G LCK TSPAN7 SDC1 PICK1 PLCG1 PECAM1 JAM2 JAM3 ITGA6 CD47 ATP1B2 ATP1B1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GRB7 SLC7A5 GPC1 SIRPA;SIRPB1;SIRPG ITGAX ITGA3 SLC16A1 PF4;PF4V1-1 ITGAM MERTK VPREB3 VPREB1 SLC16A8 ITGB1 SLC16A3 FCAMR IGLL5;IGLL1 GYPC CD99L2 GLG1 INPP5D SELE ITGAV SELP ESAM SPN CD48 SELPLG CD2 MAG CD244 SLC3A2 BSG CAV1 ATP1B3-1 F11R FN1 PPIA PIK3R2 PIK3CB HRAS PIK3R1 FYN NRAS PIK3CA PTPN11 PTPN6 TGFB1 ANGPT4 CD74 ANGPT2 ANGPT1 DOK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MMP1 TEK GRB14-1 SHC1-1 ITGB3 PROS1 THBD CD177 LYN ITGAL CD44 TREM1 F2 MIF ITGA4 PPIL2 PROCR CXADR ITGA5 L1CAM JAML PROC OLR1 SLC7A11 SLC7A10 CD99 GAS6 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes BCL2L11 FASLG DDIT3 BBC3 FOXO4 FOXO3 STK11 EP300 FOXO1-1 PINK1 NFYA-1 BCL6 NFYB NFYC CREBBP CITED2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival TRAF6 NGF NFKB1 UBB;UBC IKBKB RELA NGFR SQSTM1 NFKBIA IRAK1 RPS27A UBA52 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 TXN RBX1 MAFG BCL2 BCL2L1 SOD3 GSK3B ABCF2-H2BE1;ABCF2 PGD SQSTM1 CREBBP CHD6 SP1 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 SRXN1 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 EGF PSMD3 ME1 PRDX1 PSMB1 PSMD1 ADRM1 MYC PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PDGFA PSMC6 PSMA4 MAFK AREG BTRC PSMC3 NFE2L2 PSMA1 PRKAA2 NQO1 HMOX1 PSMC4 PSMC1 SKP1 CCL13;CCL2 TXNRD1 G6PD ABCG2 IDH1 GSTA3;GSTA1 UBA52 KEAP1 ATF4 CUL1 RELA TALDO1 GCLC GCLM EP300 TKT RPS27A CDKN2A BACH1 UBB;UBC NFKB1 SLC7A11 ABCC3 ABCC1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins NUP133 PML NUP107 MDM2-2 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 PIAS4 NUP205 NUP42 UBE2I AAAS NUP160 NUP43 NUP85 TPR NUP214 PIAS1 NUP88 TRIM27 RAE1 RANBP2 NUP155 SUMO1 NUP153 NUP35 NUP62 NUP37 VHL NDC1 SEC13 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response FLNA RNASEL OASL OAS1 ABCE1 PDE12 OAS3 DDX58 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium CNGA2 CNGA4 ARF4-1 EXOC8 EXOC7 RAB8A EXOC4 EXOC3 RAB11FIP3 EXOC6 EXOC5 RAB3IP EXOC2 CNGB1 EXOC1 ASAP1 PKD2 RHO PKD1 GBF1 RAB11A SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RPS14 RPS17 TBK1 RPS16 RPS19 RPS18 CHMP3 RPS11 CHMP6 CHMP7 RPS10 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 ST6GAL1 MOGS ACE2 PIK3R4 ST3GAL4 SFN RIPK3 SMAD2;SMAD3 ST3GAL1 ST3GAL2 ST3GAL3 PARP16 PYCARD PARP14 PARP10 RPS25 RPS27 CASP1 RPS29 RPS20 RPS21 RPS24 RPS23 IFIT1 YWHAE IKBKE IFIT3 IFIT2 TOMM70 PARP6 PARP4 SFTPD HNRNPA1-1 PSMC6 PARP9 YWHAG PARP8 EEF1A1 PPIB SIKE1 DDX58 CANX TLR7 TMPRSS2 RPS27L IFIH1 RPS15A TRIM25 YWHAB RPS3 MGAT1 UBA52 RPS2 YWHAZ MPP5 STING1 FAU EP300 VCP-1 RPS27A KPNA2 UBB;UBC RPS9 RPS7 RPS8 RPS5 RPS6 RPSA ZCRB1 NPM1-2 DDX5 BCL2L1 TKFC PCBP2 IRAK2 NLRP3 GSK3B KPNB1 UVRAG CAV1 UBE2I MAVS SP1 GSK3A ST6GALNAC2 PRKCSH ITCH RPS4X SUMO1 YWHAQ YWHAH PDPK1 RPS3A FKBP1A IRF3 TRAF3 PPIA SMAD4 TRAF6 PIK3C3 ST6GALNAC3 ST6GALNAC4 BECN1 GANAB VHL GALNT1 CTSV;CTSL BST2 RUNX1 CHMP4C CHMP4B CHMP4A RCAN3 NFKBIA PPIH PPIG RELA NMI CHMP2B CHMP2A NFKB1 RB1 RPS15 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 GYG2 GYS2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence MCM2 BRCA1 TERT MCM5 LIG1 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 NFE2L2 PSMA1 PSMC4 PSMC1 SKP1 GSK3B UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism GLB1L2 GNS SLC35D2 GLB1L GLB1 FMOD CHST6 LUM B4GALT6 B4GALT4 B4GALT5 PRELP KERA CHST1 OGN ST3GAL4 CHST2 ST3GAL1 ST3GAL2 ST3GAL3 CHST3 OMD ACAN GALNS B4GAT1 B4GALT2 B4GALT3 B4GALT1 B3GNT7 B3GNT4 B3GNT3 B3GNT2 HEXB HEXA GLB1L3 ST3GAL6 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC22A2 SLC22A1 SLC22A18 SLC22A3 RUNX1 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 RSC1A1 SLC22A4 SLC22A5 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer FGF20 FLT3LG FGF23 PDGFB CD19 TGFA PIK3R3 CD28 PIK3R6 PIK3R5 STRN GAB2 CD86 FGF2 KLB CD80 PDGFRB FGF19 FGFR4 IRS2 TRAT1 FLT3 PIK3AP1 ESR1 LCK SRC PIK3CD PIK3CG IRS1 PIK3R2 EGF ESR2 PIK3CB ERBB2 EGFR PIK3R1 PDGFRA FYN FGF6 HGF FRS2 GAB1 PIK3CA MET PTPN11 AREG RAC1 NRG1 NRG2 FGF7 EREG BTC FGF22 FGF3 NRG3 FGF10 NRG4 HBEGF KIT NTRK3 EPGN NTRK2 BDNF NTF3 RHOG VAV1 FGF1 FGF4 FGF16 FGF9 FGF18 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 RIN2 AKT2 AKT3 RAB5B RAB6B CCZ1;CCZ1B TRAPPC3 TRAPPC1 ANKRD27 DENND4B DENND4A TRAPPC4 TRAPPC5 DENND4C HPS1 RAB39A HPS4 RAB27A RAB39B RAB27B RAB9A TRAPPC8 TRAPPC9 MON1A RAB9B MON1B DENND1C DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 TRAPPC6A TRAPPC6B RAB7B RAB3IP RAB1A RAB5A YWHAE RAB1B RAB21 ALS2CL CHML RIC1 TRAPPC10 RAB6A RGP1 RAB10 RAB13 RAB18 RAB3GAP2 RAB3GAP1 RAB8A CHM SBF1 SBF2 RAB7A RAB14 AKT1 RAB3A DENND5B RABGEF1 RINL RAB5C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TRAPPC2L ALS2 GAPVD1 RAB32 RAB31 RAB35 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation SNAI1 FGFR1 EOMES TBXT DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression PTK6 HIF1A PELP1 NR3C1 EPAS1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases IL1RAPL1 SLITRK6 LRRC4B PPFIA1 PPFIA4 PPFIA3 PPFIBP1 PPFIA2 PTPRF SLITRK3 SLITRK5 PTPRD PPFIBP2 SLITRK2 NTRK3 SLITRK1 PTPRS SLITRK4 IL1RAPL2 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition FBXL18 CCNA2-1 TUBG2 CCNA1 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 HMMR CDC25B PSMA7 PSMD8 MYBL2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE CEP57 CETN2 ADRM1 CEP164 CCP110 AKAP9-1 PSMC2-1 PPP1CB PSMA2-1 MAPRE1-1 PSMA5 SEM1 TPX2 PRKACA-1 ACTR1A PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 CNTRL PSMC6 CEP250 PSMA4 NEK2 BTRC CDKN1A PSMC3 CEP290 PSMA1 YWHAG PSMC4 RAB8A PSMC1 SKP1 CDK5RAP2 HSP90AA1 OPTN-1 HJURP CEP135 PPP1R12A BORA MIS18BP1 FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 XPO1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 CDK2 HAUS8 PRKAR2B PPP2CB;PPP2CA HAUS7 CEP70 CEP72 EP300 CEP192 RPS27A PHLDA1 PCNT PPP2R1B OBI1 CEP76 LCMT1 CLASP1 PPME1 UBB;UBC CEP78 TICRR PLK4 OFD1-1 FOXM1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ CDC25C ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E FBXL7 CEP41 CEP43 RBX1 CDK7 GTSE1 FKBPL MNAT1 PPP2R3B HSP90AB1 PKMYT1 TP53 WEE1 SGO1 RBBP4 CENPF LIN54 LIN37 LIN9 LIN52 PPP2R2A;PPP2R2D FZR1 CCNH TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters POLRMT MTERF1-1 TFB2M TFAM-1 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass DTL RBX1 UBE2B UBA7 ISG15 UBE2L6 POLK RAD18 POLE TRIM25 RFC1 POLD1 PCNA UBA52 POLI POLH DDB1 USP10 PCLAF USP43 RPA1 SPRTN RPA2 NPLOC4 UFD1 POLD3 POLD4 POLD2 RPA3 VCP-1 USP1 RPS27A RFC5 RFC3 RFC4 POLE4 CUL4A UBB;UBC RFC2 REV1 POLE2 MAD2L2 RCHY1 REV3L POLE3 CUL4B WDR48 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA7;CHRFAM7A CHRNA2-1 CHRNA1 CHRNB4 CHRNA9 CHRNA3 CHRNB3 CHRNA5 CHRND CHRNA4 CHRNA6 CHRNG CHRNE RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions MED30 TLR2 MED13L RBX1 MED1 IFNAR1 CDK8 MED4 MED6 MED7 BCAP31 CCNC-1 SDC4 MAVS SDC2 CREBBP SDC3 HSPG2 IRF3 TLR6 SDC1 MED16 MED17 MED12 MED14 MED13 BECN1 MED10 MED8 JAK1 MED9 CUL5 MED19 MED15 MED18 IFNB1-4 MED11 TYK2 MED27 TLR3 MED23 LY96 DDX58 MED26 MED24 CDK19 MED29 TLR7 ISG15 UBE2L6 CD14 HERC5 MED22 MED20 TLR4 IFIH1 MED25 TRIM25 GPC1 ARIH1 MED21 GPC3 H2BC15;H2BC3;H2BC11;H2BC12 GPC2 GPC5 UBA52 CX3CR1 GPC4 GPC6 CLEC4M;CD209-2 STAT2 MED31-1 AGRN EP300 RPS27A MED28-1 MAP1B UBB;UBC ELOC-1 EIF2AK2 ELOB SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes HVCN1 CATSPER1 KCNU1 CATSPER3 CATSPERB CATSPER2 CATSPERD CATSPER4 CATSPERG ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement STAT3 CTNNA1 CDH1 JUP JAK2 PSMD12 VCL RNF19B PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 CDC42 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 IL6ST PSMB1 PSMD1 JAK1 ADRM1 CTSS PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 TYK2 PSMA3 CTNND1 PSMC6 PSMA4 FARP2 CBLL1 PSMC3 PSMA1 PSMC4 CDH11 PSMC1 BIRC2 CTNNB1 RAC1 CTSB CTSV;CTSL ELMO1 DOCK1 IL6R UBA52 TIAM1 RELA TRAF7 RPS27A UBB;UBC NFKB1 IL6 VAV2 HACE1 ARHGEF4 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling MTOR RRAGA RRAGC RRAGB SLC38A9 MLST8 FKBP1A RRAGD EIF4E RPTOR EIF4B EEF2K LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 AKT1S1 RHEB RPS6 EIF4EBP1 EIF4G1 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling PTPN18 PTPN9 PTPN11 TBK1 SMAD2;SMAD3 PTPN6 PTPN5 PTPN2 PTPN20 PTPN12 STAT3 PTPN23 PTPN7 PTPN14 IL37 CASP1 IL18R1 PTPN13 IL18BP SIGIRR PTPN4 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 BCL2L11 MDM2-2 WWTR1 HDAC4 CREBBP JAG1 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 LEF1 ZFHX3 RBPJ PSMA7 PSMD8 SRC PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 SMAD4 PSMB5 SMURF2 PSMB2 SMURF1 TP53 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAML3 ADRM1 MYC PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 HES1 PSMC5 PSMA3 SNW1 PSMC6 MAMLD1 PSMA4 CDKN1A PSMC3 PSMA1 TEAD1 PSMC4 TEAD2 PSMC1 TEAD3 KAT2B CTNNB1 TEAD4 BRD2 KAT2A TCF7 FOXO3 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 TCF7L1 ITGAL UBA52 ITGA4 SPP1 YAP1-1 EP300 TCF7L2 RPS27A CDKN2A UBB;UBC CCN2 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling CDK1 MAPKAPK5 PAK1 PAK3 FOXO1-1 PRKACB-1 CCND3 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 CDC42EP5 PSMB4 PSMD7 CDC42EP3 CDC42 CDC42EP2 PSMB5 PSMB2 RAG2 PSMB3 PSMD2 RAG1 PSMD3 PSMB1 PSMD1 ADRM1 MYC PSMC2-1 PSMA2-1 PSMA5 PRKACA-1 NCOA3 SEM1 PSMA6 JUN PSMC5 PSMA3 DNAJB1 PSMC6 PSMA4 TNRC6C MOV10 TNRC6A-1 PSMC3 PSMA1 AGO4 PSMC4 AGO2 PSMC1 AGO3;AGO1 RAC1 TNRC6B FOXO3 KALRN HSPB1 XPO1 UBA52 PAK2 SEPTIN7 CDC14A CDC14B ETV4 IGF2BP1 MAPK6 MAPK4 RPS27A UBB;UBC PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex TPTEP2-CSNK1E;CSNK1E PPP1CA CSNK2A2 PER2 CSNK2A1;CSNK2A3 PER1 CDK5 PPP1CC CSNK2B CRY2 CRY1 CSNK1D PPP1CB UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle CPS1 ARG1 ARG2 ASL TP53 ASS1 OTC NMRAL1 NAGS SIRT5 SLC25A15 SLC25A2 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones INHA INHBE FSHB LHB CGA TSHB INHBB INHBA INHBC PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer FGF20 FLT3LG FGF23 PDGFB CD19 BAD MDM2-2 TGFA PIK3R3 CD28 PIK3R6 AKT2 PIK3R5 STRN AKT3 GAB2 CD86 FGF2 KLB CD80 FOXO1-1 GSK3B PDGFRB FGF19 FGFR4 AKT1S1 IRS2 TRAT1 RPS6KB2 FLT3 PIK3AP1 ESR1 GSK3A PRR5 LCK PDPK1 PTEN MLST8 SRC PIK3CD PIK3CG MAPKAP1 IRS1 PIK3R2 EGF ESR2 PIK3CB ERBB2 NR4A1 EGFR PIK3R1 PDGFRA FYN FGF6 HGF FRS2 GAB1 PIK3CA MET PTPN11 MTOR AREG CDKN1A CDKN1B RAC1 CHUK FOXO4 NRG1 FOXO3 NRG2 FGF7 EREG BTC FGF22 FGF3 NRG3 FGF10 NRG4 HBEGF KIT NTRK3 EPGN AKT1 TSC2 NTRK2 BDNF RICTOR NTF3 RHOG VAV1 CASP9 FGF1 FGF4 FGF16 FGF9 FGF18 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly CENPT CENPU RBBP4 NPM1-2 CENPN-2 KNL1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HJURP RSF1 CENPH MIS18BP1 OIP5 RBBP7 CENPW CENPI MIS18A CENPK CENPL CENPM H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 CENPO CENPP H2BC21 H2BC1 CENPQ SMARCA5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CENPX H2AC4 CENPA CENPC RUVBL1 ITGB3BP CENPS-CORT;CORT;CENPS H2AC14 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLBD1 PLA2R1 ABHD4 PLA2G3 PLA2G5 PLA2G10;LOC100652777 PLA2G2F PLA2G6 PLA2G2D PLA2G2E PNPLA8 MBOAT1 MBOAT2 LPCAT4 LPCAT3 PLA2G2A-1 PLA2G12A PLA2G4F JMJD7-PLA2G4B;PLA2G4B PLA2G4D PLA2G4E DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) PSMD12 PSMD11 PSMD14 PSMD13 PPP3R1 PSMA7 PSMD8 PSMB6 FKBP1A PSMB7 PSMD6 PSMB4 NFATC2 PSMD7 PPIA NFATC1 PSMB5 PSMB2 PSMB3 PPP3CA PSMD2 PPP3CB PSMD3 PSMB1 PSMD1 HRAS ADRM1 PSMC2-1 PSMA2-1 PSMA5 NRAS SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NFKBIB BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK REL FBXW11 CALM3;CALM1 RASGRP3 NFKBIE IKBKB CARD11 BCL10 IKBKG RASGRP1 MALT1 UBA52 NFKBIA NFATC3 CUL1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 PRKCB SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PTPMT1 PLD4 PLD6 PLD1 CDS2 PLD3 PLD2 PGS1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 METHYLATION%REACTOME%R-HSA-156581.6 Methylation MTR-1 COMT NNMT MTRR MAT2B N6AMT1 AHCY TPMT TRMT112 MAT2A GSTO1 AS3MT MAT1A CYP1A2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation NGF RAP1A YWHAB BRAF KIDINS220 CRK NTRK1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion PLCB1 PLCB2 GNA14 FFAR1 GNA15 CD36 GNAQ GNA11 PLCB3 ACSL4 ACSL3 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein MGAT4C MGAT4B FUT8 CANX MAN2A1 ZDHHC20 ST6GAL1 OST4 MOGS MGAT5 RPN2 OSTC STT3A RPN1 MGAT1 STT3B ST3GAL4 MGAT2 ST6GALNAC2 PRKCSH ST3GAL1 MGAT4A-1 ST3GAL2 ST3GAL3 EDEM2 ZDHHC9 DDOST DAD1 TUSC3 MAN1B1 ST6GALNAC3 ST6GALNAC4 MAGT1 ZDHHC5 GANAB ZDHHC8 ZDHHC2 GOLGA7-1 ZDHHC3 TMEM258 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation PMPCA MICU2 NDUFS1 ALDH1B1 HTRA2 TFAM-1 TWNK ACADSB STAR SSBP1 FECH ACAT1 UQCRQ UQCRC2 ACO2 SHMT2 ALAS1 MRPS10 COX4I1 TIMM17A-1 CHCHD2 ACAD8 COX5B MRPL32 OPA1 SLC25A5 ACOT2;ACOT1 NADK2 OXSM ECH1 COX5A TIMM22 ATP5PF CLPX ATP5PD ME2 CLPP TIMM10 SLC25A6 LDHD ALDH18A1 PRELID1 LONP1 PRKACA-1 ATP5PO NDUFA13 HSPD1 HMGCS2 ATP5F1A IDH3A ATP5F1B CS STARD7 MRPS2 HADH NDUFB6 ATP5F1C PDHB ARG2 PCCB ATP5MG OGDH HSD17B10 IDH2 HSPA9 ECI1 NDUFV3 GLUD1;GLUD2 BDH1 DLD NDUFV1 MRPL12 FH ALDH2 PDK1 DBT OXCT1-1 SPG7 PDHA1 MDH2 SUCLG2 IARS2 AFG3L2 SMDT1 YME1L1 NDUFS3 OMA1 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease FGF20 NCBP1 BCR SOS1 FGF23 CEP43 STAT3 GAB2 FGF2 FGFR4 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I LRRFIP1 FGFR1OP2 STAT5A STAT5B NCBP2-1 PLCG1 HRAS PIK3R1 FGF6 NRAS FRS2 CPSF6 GAB1 PIK3CA FGFR3 FGFR2 FGFR1 TRIM24 POLR2E FGF7 POLR2F GTF2F1 POLR2H GTF2F2 FGF22 FGF3 BAG4 FGF10 POLR2L ERLIN2 STAT1 MYO18A POLR2J;POLR2J2;POLR2J3 ZMYM2 CUX1 FGF1 FGF4 FGF16 FGF9 FGF18 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU FMO3 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade TBK1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 RIPK3 APP NFKB2 IKBKE RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 BIRC2 CHUK BIRC3 OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 TANK MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP TRAF2 TICAM1 CASP8 LRRC14 USP14 RIPK1 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 UBE2D3;UBE2D2 NFKBIA UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer CLIP1 PIK3CA PIK3R2 PIK3CB MAPK1 PIK3R1 MAPK3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC PFDN6 TUBA1A CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 CCT6A TUBA4A CCT6B PFDN4-1 TUBA1C TUBB1 CCT3 CCT2 TUBB2B;TUBB2A VBP1 TCP1 TUBB4B PFDN1 PFDN2 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 GNB3 GNGT1 GNB5 GNG10 GNG2 GNG5 GNG4 P2RY12 GNG8 GNAT3 GNAI1 GNAI3 GNAI2 GNG13 GNB2 GNB1 GNB4 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells EGF AREG TGFA GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 NRG1 NRG2 EREG BTC EGF NRG3 ERBB2 NRG4 EGFR HRAS HBEGF NRAS IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) TLR5 MYD88 TLR10 IRAK4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation DYNC1LI1 SPTBN2 DYNC1LI2 KIF18A CTSO ACTR1B CTSH CTSF CTSE CTSC HLA-DMA HLA-DMB SEC31A KIF11 DYNC1I1 KIF15 CAPZA3 CTSA ACTR10 CAPZB HLA-DOA HLA-DOB SAR1B KIF3A KIF23 KIF22 DCTN6 DCTN5 HLA-DPB1-1 DCTN4 KIF2A HLA-DQB2;HLA-DQB1 OSBPL1A HLA-DPA1 RILP KIF2C HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 KIF2B DCTN1 HLA-DRA SEC23A CENPE LGMN KIF26A CAPZA1 CTSS CAPZA2 SEC24B ACTR1A SEC24A CTSK ARF1 SEC24C CTSD CTSB LAG3 CTSV;CTSL CANX CD74 RAB7A CLTC CLTA AP2A1 AP2B1 DYNC1I2 AP2A2 AP1G1 DCTN2 DNM1 AP1S2 DNM2 DCTN3 AP1S1 DNM3 SEC24D-1 AP1S3 AP2S1 KIF5B KIF5A SH3GL2 AP1B1 KIFAP3 KIF4B;KIF4A KIF20A KLC1 DYNC1H1 AP1M2 KLC4 KLC3 AP1M1 KLC2 RACGAP1 IFI30 KIF3B SEC13 KIF3C SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus PIP4P1 PIP4K2A PIP4K2B PIP4K2C FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins ADAR ADARB1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor GNB3 GNGT1 GNB5 PTGIR GNG10 GNAS-1 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle SRGAP3 SRGAP2 GNA13 SRGAP1 STOM FMNL3 FMNL1 MAP3K11 FMNL2 RASGRF2 SNAP23 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 ARFGAP3 ARFGAP2 WASL PARD6A IQGAP1 ARHGAP5 CDC42BPB ARHGAP21 BAIAP2 CDC42BPA DOCK7 CPNE8 LBR OPHN1 TMPO ARHGAP35 SCRIB SPATA13 KTN1 VANGL1 ARAP1 DEPDC1B DOCK10 DOCK11 SH3PXD2A GIT1 VAV3 TRIO RALBP1-1 TFRC WIPF1 LAMTOR1 WIPF2 ITSN1 WIPF3 STEAP3 FNBP1L VAV2 PREX2 PREX1 WDR91 ARHGEF4 RACGAP1 FNBP1 STARD8 BCR ARHGEF7 ARHGEF5 WDR81 ARHGEF6 DAAM1 NGEF WAS DOCK6 IQGAP2 PAK1 IQGAP3 DOCK9 DOCK8 ABR PAK3 PAK5 PAK4 STARD13 JUP GIT2 CAV1 MYO9B DLC1 CDC42SE2 ARHGAP9 ARHGAP1 ARHGAP4 BUB1B-PAK6;PAK6 ARHGDIG GMIP ARHGAP39 ARHGAP44 CDC42EP5 CDC42EP4 SYDE1 CDC42EP3 CDC42 ARHGAP42 CDC42EP2 CDC42EP1 ARHGDIA VAMP3 ARHGDIB PIK3R2 KCTD3-1 PIK3R1 FGD1 ARHGAP45 FGD2 FGD3 FGD4 ARHGEF26 ARHGEF25 CHN1 YKT6 ARHGAP17 FARP1 ARHGAP22 ARHGAP20 MCF2 DEF6 ECT2 ARHGAP29 ARHGAP27 RAB7A SHKBP1 ARHGAP26 ARHGAP24 ARHGAP33 PLD1 ARHGAP32 ARHGAP31 ARHGAP30 PAK2 DIAPH3 TIAM1 DNMBP FAM13B MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF16 ARAP2 ARHGEF19 ARAP3 ARHGAP10 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants SOS1 HSP90AA1 NRG1 NRG2 EREG BTC EGF CDC37 SHC1-1 ERBIN NRG3 ERBB2 NRG4 PLCG1 EGFR HRAS HBEGF NRAS CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction SCN1A KCNJ2 KCNJ12;KCNJ18 KCNE2 KCNE3 KCNE4 KCNJ4 KCNE5 FGF14 FGF13 FGF12 WWTR1 FGF11 ABCC9 SCN3B SCN3A KCNK5 KCNK10 SCN2A KCNK12 SCN2B CACNG6 KCNJ14 KCNK13 KCNK15 TNNI3 KCNK16 KCNK18-1 RANGRF KCNK17 CACNB2 KCNK2 CACNA2D2 KCNK4 SCN9A NPPA SCN8A ITPR1 ITPR2 ITPR3 SCN5A SCN4A SCN4B SCN7A KCNK6 KCNK7 CACNG7 KCNK1 NKX2-5 AKAP9-1 PRKACA-1 KAT2B ATP1B2 ATP1B1 KCNJ11 CACNG8 CACNG4 STIM1 ORAI2 KCND1 ORAI1 KCND2 KCNIP1 HIPK1 KCND3 KCNIP2 KCNIP4 HIPK2 CACNA1C FXYD4 FXYD3 GATA4 FXYD1 FXYD6 RYR1 RYR2 RYR3 CLIC2 KCNK9 TRDN KCNK3 ASPH NOS1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 KCNIP3 ATP1B3-1 FXYD2;FXYD6-FXYD2 FKBP1B MME NPR1 NPR2 NPPC CORIN CAMK2B TRPC1 CAMK2D CAMK2A CAMK2G SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 KCNQ1 SCN11A SCN10A DMPK KCNE1;KCNE1B CES1 AHCYL1 TBX5 KCNA5 KCNH2 CACNB1 SCN1B CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence MINK1 ETS2 EP400 CCNA2-1 HMGA2 CCNA1 CABIN1 BMI1 ETS1 KDM6B ASF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RING1 KAT5 RNF2 UBN1 CDKN2D CDKN2C CBX8 ERF H2AC20 TNIK CBX6 PHC2 H2AB2;H2AB3;H2AB1 IGFBP7 PHC1 EZH2 CBX4 CBX2 PHC3 TFDP1 TFDP2 E2F1 E2F3 JUN ATM MAP4K4 CXCL8 MAPK7 CDKN1A CDKN1B H2AJ FOS SUZ12 CDKN2B H2BC5 UBA52 H2BC1 MAPKAPK2 CDK4 CDK2 ID1 RPS27A RPS6KA3 RPS6KA2 H2AC4 UBB;UBC RPS6KA1 MRE11 MAP2K3 MAPK14 MAP2K4 MAPK11 MAPKAPK3 NBN MAPK9 MAPK8 MAP2K7 MAPK10 CDK6 MAPKAPK5 TXN MDM2-2 STAT3 ACD TINF2 MAP2K6 TERF2 POT1 TERF2IP TERF1-1 SP1 MDM4 H2BC21 EED H2AZ2;H2AZ1 IL1A TP53 IFNB1-4 E2F2 TNRC6C RAD50 MOV10 TNRC6A-1 AGO4 RBBP4 AGO3;AGO1 HIRA TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 LMNB1 H2BC15;H2BC3;H2BC11;H2BC12 CEBPB ANAPC15 H1-0 ANAPC16 H1-3 UBE2D1 H1-2 H1-5 RELA ANAPC10 H1-4 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 MAP3K5 NFKB1 IL6 UBE2S CDC16 CCNE2 ANAPC4 MAPK1 CCNE1 ANAPC5 RB1 ANAPC1 MAPK3 ANAPC2 EHMT2 EHMT1 H2AC14 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 CHEK1 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 RAD51AP1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 XRCC3 PALB2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PIKFYVE ARF1 FIG4 PI4KA SACM1L PI4KB INPP5E PI4K2B PIK3C3 OCRL TPTE;TPTE2 PIK3C2G PIK3C2A PI4K2A VAC14 PIK3R4 DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE MTR-1 MTRR MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins VPS37C VPS37D VPS37A VPS37B RPS27A NMT2 UBAP1 UBB;UBC VPS28 TSG101 MVB12B MVB12A UBA52 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSEN2 APH1A APH1B NOTCH3 YBX1 PSEN1 PSENEN NCSTN TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript NCBP1 CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers DPF1 PHF5A DPF2 SNRPD2 DPF3 SNRPD1 SMARCC1 SNRPN SMARCC2 SNRPD3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SS18L1 SNRPE-2 SMARCA2 SMARCA4 H2AC20 H2AB2;H2AB3;H2AB1 SSRP1 CBX3-1 SS18 ACTL6A MAFK NFE2L2 CTNNB1 H2AJ CDC73 TCF12 LEO1 AXIN2 SF3B1 MBD3 H2BC5 MBD2 H2BC1 BRD7 GATAD2B GATAD2A CHD9 EP300 H2AC4 CHD2 TCF4 SNRPF SNRPB CTR9 RTF1 ACTB-1 MYOG PAF1 FBP1 DHX15 MYOD1 UBE2I CHD4 G6PC1 CHD3 CHD8 CHD7 BCL7A CHD6 CTCF H2BC21 NKD2 FAM124B BCL7C IGF2 BCL7B PWWP2B DDX46 DDX42 CHD5 IKZF1 WDR5 IKZF2 SUMO1 RBM17 IKZF3 PHF6 MBD3L1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 ADNP2 ARID1A ZNF687 ARID1B TCF19 ADNP ZNF592 ZNF827 SMNDC1 CBX1 U2SURP NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 DKK2 SMARCD1 BCL11B PHF10 SMARCD2 SNRPG-2 HDAC2 SMARCD3 NR2C2 HDAC1 SF3B4 SF3B5 MTA1 SF3B2 SF3B3 RBBP4 NQO1 SF3B6 SF3A3 SF3A1 SUPT16H H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SF3A2 BICRAL BICRA BRD9 RBBP7 MTA2 MTA3 SMARCE1 CHERP H2BC15;H2BC3;H2BC11;H2BC12 PBRM1 ACTL6B PUF60 SNRPB2 BCL11A SNRPA1 WDR61 SMARCB1 PCK1 ARID2 H2AC14 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK MTOR PRKAA2 PRKAG1 SLC38A9 PRKAG3 RPTOR STK11 PRKAB2 RHEB TSC2 TSC1 PRKAB1 CAB39 PPM1A RRAGA RRAGC RRAGB MLST8 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKAA1 CAB39L STRADA PRKAG2 STRADB VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs ABL1 GATA3 CDK7 MNAT1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 PSMD12 PSMD11 PSMD14 PSMD13 ITCH LMO1 PSMA7 H2AC20 LMO2 LDB1 PSMD8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 TP73 PSMC3 PSMA1 PSMC4 PSMC1 H2AJ TCF12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TAL1 CBFB RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MYB UBA52 H2BC1 YAP1-1 RPS27A H2AC4 UBB;UBC GATA2 GATA1 CCNH KMT2A SPI1 H2AC14 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage HPRT1 ADAL TK2 PNP-1 UCK1 TK1 APRT DGUOK TYMP GMPR AMPD1 AMPD2 AMPD3 CDA PUDP GMPR2 DCK UPP1 ADA UCKL1 ADK TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI RPA1 RPA2 RPA3 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC REV1 RFC1 MAD2L2 REV3L PCNA UBA52 POLI AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO1-1 NR4A1 AKT2 AKT3 RPS6KB2 FOXO4 FOXO3 AKT1 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling CAMK2G PRKCE ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG ITPR1 ITPR2 PRKCD NBEA PRKCA ITPR3 CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 AHCYL1 KPNA2 PLCG1 PRKX CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis ANGPTL3 NR1H3 RXRA FASN NRIP1 RXRB NR1H2 SCD PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis STARD3NL TSPOAP1 AKR1B1 FDXR STARD3 STARD4 STAR STARD6 TSPO FDX1 CYP11A1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway S100A8 TLR2 B2M SNAP23 TIRAP HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E STX4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 TLR6 SEC61A2 PSMB5 PSMB2 SEC61A1 VAMP3 PSMB3 PSMD2 SEC61G PSMD3 SEC61B PSME1 PSMB1 PSMD1 SEC22B PSMB10 CD36 PSMB8 ADRM1 PSMB9 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 MYD88 PSMA4 PSMC3 PSMA1 LY96 PSMC4 PSMC1 CHUK BTK CD14 HMGB1-1 TLR4 IKBKB IKBKG FGB FGA UBA52 FGG CALR-1 VAMP8 PSME2 RPS27A S100A1 UBB;UBC TAP2 TLR1 TAP1 PDIA3 TAPBP S100A9 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes ATF4 NFYA-1 NFYB DDIT3 NFYC ATF6 CALR-1 HSPA5 HSP90B1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling SOS1 PSMD12 FCER1A PSMD11 ITPR1 FCER1G PSMD14 ITPR2 PSMD13 ITPR3 PPP3R1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 NFATC2 LAT2 PSMB4 PSMD7 NFATC1 PSMB5 PSMB2 PSMB3 PSMD2 PPP3CA PSMD3 PPP3CB PLCG1 PSMB1 PSMD1 ADRM1 PSMC2-1 MS4A2 PSMA2-1 PSMA5 SEM1 TEC PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 RAC1 CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 TXK NFATC3 CUL1 VAV3 RPS27A UBB;UBC MAP3K7 VAV1 VAV2 MAP2K4 MAPK9 MAPK8 MAP2K7 MAPK10 UBE2V1 GRAP2 GAB2 PAK1 LCP2 UBE2N TAB3 TAB2 TAB1 ITK PDPK1 TRAF6 SYK PIK3R2 PIK3CB HRAS PIK3R1 FYN NRAS PIK3CA PLCG2 CALM3;CALM1 MAP3K1 CDC34 PRKCQ CARD11 BCL10 RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 NFKBIA PAK2 UBE2D1 RELA AHCYL1 NFKB1 MAPK1 MAPK3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism GLB1L2 VCAN GLB1L GLB1 HYAL1 CHST11 HYAL3 CHST12 HYAL4 IDS CHSY3 CHPF2 CHST15 CSPG5 GUSB ARSB CHST13 CHST7 CHSY1-1 CHST14 CHPF CSGALNACT1 DCN CSGALNACT2 DSEL BCAN CHST3 UST DSE IDUA HEXB NCAN HEXA BGN GLB1L3 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic COG4 COG3 PLA2G4A COG2 BET1L RAB30 IGF2R RAB36 RAB6B ALPG;ALPP;ALPI-1 GOSR2 AGPAT3 CAPZA3 ACTR10 RAB39A ARFGAP3 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 M6PR NSF TMED2-1 RAB1A RAB1B RIC1 RAB6A ACTR1A VAMP4 RAB33B-1 RGP1 RAB18 RAB3GAP2 ARF1 RAB3GAP1 ZW10 TRIP11 GBF1 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 KIF5B KIF5A COPB1 MAN2A2 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 KDELR1 DYNC1LI2 KIF18A GCC2 KIF18B SURF4 MAN2A1 KIF12 KIF11 DYNC1I1 KIF15 KIF19 CAPZB KIF13B MAN1A2 KIF1C MAN1C1 MAN1A1 KIF1B KIF3A KIF1A KIF25 KIF23 RAB9A KIF22 KIF6 KIF27 RAB9B KIF9 KIF2A KIFC2 KIFC1 KIF2C KIF2B DCTN1 VAMP3 SEC22B CENPE KIF26A CAPZA1 KIF26B CAPZA2 USP6NL BICD1 SCOC BICD2 SYS1 STX5 GALNT2 GCC1 PAFAH1B3 YKT6 GALNT1 GOLGA1 PAFAH1B2 ARFIP2 RINT1 KDELR2 COPB2 VPS45 COPA ARL1 COPE USE1 RABEPK TMED3 TMED7 NAA30 TMED9 COPZ2 COPZ1 NAA35 NAA38 NAPB TMED10 ARF5 NBAS TMF1 STX18 NAPG STX10 ARFRP1 VPS51 PLA2G6 VPS53 VPS52 BNIP1 VPS54 ARCN1 COPG2 COPG1 GOLGA4 PLIN3 NAPA TGOLN2 STX16 GOSR1 GOLIM4 RHOBTB3 ARFGAP1 CYTH3 CYTH2 GOLGA5 CYTH4 CUX1 STX6 VTI1A CYTH1 COG8 COG7 COG6 KDELR3 COG5 SNAP29 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease TALDO1 RPIA MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF SOS1 PDGFB STAT3 COL4A5 THBS2 PDGFRB NCK2 NCK1 STAT6 STAT5A STAT5B SRC PIK3R2 PIK3CB PLCG1 COL9A1 HRAS COL9A3 PIK3R1 COL9A2 PDGFRA RASA1 PLAT COL4A2 COL4A1 NRAS COL4A4 THBS1 COL6A2 PIK3CA COL4A3 COL6A1 PTPN11 COL6A3 COL6A6 COL6A5 GRB7 CRK STAT1 THBS4 THBS3 FURIN PDGFD PTPN12 PLG BCAR1 SPP1 RAPGEF1 CRKL DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle UNC13B RAB3A SYT1 SYN3 VAMP2 STX1A CPLX1 SYN2 SYN1 SNAP25 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling CSF1R TYK2 VAMP2 STX1A IL16 CASP3 CSF1 SNAP25 IL10RB CSF3 IL34 IFNLR1 SDC1 IFNL2;IFNL3;IFNL1 STX3 STX4 CD4 JAK1 CSF3R PTPRZ1 TXLNA STXBP2 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation PRMT3 METTL21A KIN METTL22 ETFBKMT CAMKMT VCPKMT EEF1A1 FAM86B1;EEF2KMT;FAM86B2 EEF1AKMT2 ETFB VCP-1 EEF1AKMT1 EEF2 CALM3;CALM1 HSPA8 RPS2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY9 GNAL DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2R1A CTNNB1 GSK3B WNT3A CAV1 CSNK1A1 CSNK1G2 WNT1 AMER1 FZD1 PPP2CB;PPP2CA WNT8A WNT8B FZD2 AXIN1 FZD5 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAT2 PPP2R1B APC PPP2R5E DVL1 DVL2 LRP5 DVL3 LRP6 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis DHRS7B AGPS GNPAT PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling PDE3B AKT2 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism SOAT1 LPL SOAT2 NPC2 NR1H3 APOC1 MTTP APOC4 P4HB APOB MBTPS1 CREB3L3 MBTPS2 VLDLR PRKACB-1 SAR1B NR1H2 MYLIP APOF CUBN A2M ALB AMN PRKACA-1 GPIHBP1 ABCA1 APOA2 APOA1 APOA4 PCSK5 LMF2 APOA5 LMF1 LIPC ANGPTL8 PCSK6 ANGPTL3 FGF21 ANGPTL4 APOC3 CLTC CLTA AP2A1 UBA52 AP2B1 APOC2 AP2A2 LDLRAP1 FURIN AP2S1 LIPG CES3 RPS27A LCAT APOBR UBB;UBC CETP ABCG1 LDLR APOE PCSK9 HDLBP ZDHHC8 LSR LIPA NCEH1 NPC1-1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN BDNF GRIN2B SRC RAC1 DOCK3 NTRK2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RAMAC CDK7 POLR2E POLR2F POLR2H GTF2F1 MNAT1 RNMT GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 RNGTT SUPT5H POLR2J;POLR2J2;POLR2J3 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 RPL27A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 MTERF3 RPL36AL-1 RPS27L CSNK1D RPS15A LTV1 RRP1 RPS3 FTSJ3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 TEX10 DIS3 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 EXOSC7 WDR12 EXOSC6 BYSL RPL18A EXOSC5 BOP1 FAU EXOSC4 TSR1 RPL12-1 EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TPTEP2-CSNK1E;CSNK1E RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 FASTKD2 RPL9 RPL6 RPL7 RPS4X SNU13 RPL35 RPL38 RPS3A RPP30 RPL39 DDX49 DDX47 RPP38 WDR3 FCF1 RPP21 NAT10 RPP25 THUMPD1 RPL21 WDR46 RPL23 WDR43 RPP14 RRP9 RPL22 FBL LOC102724159;PWP2 RPP40 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 RPL24 DIMT1 IMP3 WDR75 RPL27 IMP4 RPL26 DDX52 RPL29 UTP18 RPL28 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L RPL15-1 NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPL3L DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 RPLP1-2 NOL11 NOP10 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 RPL11 RCC1L RPL14 NGRN MRM2 XRN2 RPL13 MRM3 RPL18 RPL17 RPL19 NCL-1 NOP56 RPL10;RPL10L-1 RPL7A RPLP0 TRMT112 PELP1 RPLP2 RPL36-1 RPL35A MTREX TFB1M RPL22L1 RPL37A-1 EXOSC10 C1D MPHOSPH6 NOP2 RPL13A-1 DDX21 RPL5-1 TRMT10C PRORP HSD17B10 RPL23A RPS15 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system PRCP C1QBP H2AC20 SERPING1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 KNG1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 F12 H2AC4 A2M KLKB1 PLAUR H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 HRG KRT1 H2BC1 H2AC14 H2BC21 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus PROC F2 F7 F9 PROS1 F10 GAS6 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism CYP24A1 CYP2R1 GC LDLRAP1 PIAS4 LRP2 CYP27B1 LGMN UBE2I SUMO2 VDR CUBN AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy DYNC1I2 HDAC6 DYNC1LI1 DYNC1LI2 UBE2V1 IFT88 HSF1 PRKN CETN1 HSP90AA1 VCP-1 RPS27A CFTR PCNT ARL13B DYNC1I1 UBB;UBC DYNC1H1 PARK7 UBE2N UBA52 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections RPS14 GJA1 SOS1 RPS17 TLR2 BRMS1 TBK1 RPS16 SNRPD2 RPS19 IFNGR1 SNRPD1 IFNGR2 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 S1PR1 VPS39 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN RIPK3 ST3GAL1 REST ST3GAL2 ST3GAL3 VPS16 SRPK2 EDEM2 PARP16 PARP14 PYCARD SRPK1 PARP10 RPS25 RPS27 CASP1 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IFIT1 IKBKE YWHAE IFIT3 JAK1 IFIT2 TOMM70 PARP6 ROCK1 PARP4 PRMT1 RIPK2 SFTPD ANO8 ANO9 HNRNPA1-1 ANO6 TYK2 ANO4 PSMC6 PARP9 IL17RC ANO5 NFE2L2 ANO2 PARP8 YWHAG IL17RA ANO3 ANO1 ATP1B2 EEF1A1 SIKE1 PPIB HSP90AA1 SMN2;SMN1 ATP1B1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 YWHAB RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 AKT1 UBA52 GPC4 RPS2 NUP214 MGAT2 GPC6 STAT1 KDM1A STAT2 SEC24D-1 YWHAZ MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 RPS27A CRB3 IL17A TUSC3 FXYD4 GEMIN2 FXYD3 UBB;UBC KPNA2 MAP3K7 FXYD1 RPS9 RPS7 FXYD6 RPS8 RPS5 VPS33A PHF21A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 RBX1 GEMIN7 GEMIN8 ISCU RCOR1 IFNAR1 ATP1A4 SNRPB ATP1A3 DDX5 FUT8 BCL2L1 ATP1A2 TKFC IRAK1 ATP1A1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG CAV1 HMG20B MAVS OSTC ATP1B3-1 STT3A JAK2 FXYD2;FXYD6-FXYD2 UBE2N TAB3 CSNK1A1 TAB2 SP1 STT3B TAB1 HSPG2 GSK3A ST6GALNAC2 HSP90AB1 ITCH PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST FKBP1A LARP1-1 IRF3 DAD1 CYSLTR1 TRAF3 MBL2-1 TRAF6 SYK IRF7 PIK3C3 MAN1B1 CRBN ST6GALNAC3 ST6GALNAC4 BECN1 FNTA SEC23A DDX20 NOD1 CUL3 NOD2 GANAB SNRPG-2 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 COMT MGAT4C VPS41 NUP107 MGAT4B PDCD1 NUP188 VPS45 SEC24C PLCG2 TLR9 CTSV;CTSL NUP210 BST2 NUP93 CHMP4C CHMP4B CHMP4A NUP205 AAAS IL6R NUP160 NUP85 PPIH TPR NUP88 PPIG NUP155 ITGA4 FURIN NUP153 CHMP2B CHMP2A NUP62 RB1 NDC1 SEC13 NUP133 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 NUP42 NCK1 CREBBP NUP43 IL1R1 RAE1 RANBP2 SMAD2;SMAD3 CD79B CD79A ROCK2 NUP35 NUP37 FNTB;CHURC1-FNTB BLNK CHUK BTK DDX58 ISG15 IFIH1 IKBKB IMPDH1 TRIM25 IMPDH2 IKBKG MBD3 AP2A1 AP2B1 KEAP1 AP2A2 GATAD2B AP2S1 GATAD2A ARID4B EP300 SAP30 VAV1 SIGMAR1 ITGB1 SUDS3 NPM1-2 PCBP2 GSK3B KPNB1 UBE2I CHD4 CHD3 ZBP1 NR3C1 SUMO1 PPIA SMAD4 FKBP4 HDAC2 JAK3 HDAC1 PTPN6 MTA1 RBBP4 BRD4 SAP30L RIPK1 SAP18 RUNX1 RBBP7 MTA2 MTA3 RCAN3 NFKBIA RELA NMI SH3KBP1 NFKB1 ARID4A PATJ ZDHHC5 ZDHHC8 TLR1 ZDHHC2 ZDHHC3 RPS15 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors TRIM28 MRTFA ZNF131 NRIP1 NPM1-2 NCOR2 SAFB DDX5 UHRF2 ING2 CASP8AP2 BMI1 MBD1 PIAS4 PIAS3 UBE2I RING1 PPARGC1A CREBBP PCGF2 SIN3A RNF2 PIAS1 ZNF350;ZNF432 DAXX CBX8 SUMO1 SUMO3 SUMO2 PHC2 PHC1 HIPK2 CBX4 EP300 CBX2 PHC3 CTBP1 TOPORS PARK7 NCOA1 DDX17 NCOA2 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions PTPN6 PTPN11 SKAP2-2 PTK2B SIRPA;SIRPB1;SIRPG FYB1 CD47 SIRPB1 PTK2 TYROBP DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay EIF4A3 PAN2 PAN3 CNOT10 CNOT4 CNOT6 CNOT7 CNOT11 CNOT1 CNOT2 CNOT3 CNOT8 SKIV2L CNOT9 EIF4A2 EIF4A1 TUT7 TUT4 EIF4E EIF4B LSM5 PAIP1 LSM4 LSM3 LSM2 TNKS1BP1 LSM7 LSM6 CNOT6L DIS3 XRN1 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 WDR61 PABPC1;PABPC3 DDX6 LSM1 PATL1 DCP1A HBS1L EDC3 EIF4G1 EDC4 TTC37 NT5C3B DCP1B DCPS PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2R1B PPP2R1A PFKFB1 PPP2CB;PPP2CA PPP2R5D DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins SOS1 PIK3CA NOX4 MYO18A STAT5A CDKN1A GOLGB1 STAT5B ETV6 GAB2 PIM1 TRIP11 ZMYM2 HRAS PIK3R1 SPTBN1 NRAS POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression ACTB-1 GSK3B CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 H2BC21 SMARCA5 H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 DDX21 TAF1D BAZ1B MTA1 TAF1B RBBP4 TAF1C KAT2B H2AJ KAT2A TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L DEK SF3B1 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 ERCC6 GATAD2B GATAD2A MYBBP1A TTF1 EP300 H2AC4 EHMT2 H2AC14 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) GYG1 GYS1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNB3 KCNJ2 GNGT1 KCNJ12;KCNJ18 KCNJ3 GNB5 KCNJ4 GABBR2 GNG10 KCNJ5 GNG2 GABBR1 GNG5 KCNJ6 GNG4 KCNJ10 GNG8 KCNJ9 KCNJ15 KCNJ16 GNG13 GNB2 GNB1 GNB4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock ARNTL2 NOCT MED1 CSNK2A1;CSNK2A3 PPP1CC PPARGC1A CREBBP ATF2 PSMD12 PSMD11 PSMD14 FBXL3 SREBF1 PSMD13 CLOCK PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 SERPINE1 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NCOA1 NCOA2 PSMC2-1 PPP1CB NCOA6 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA BTRC SIRT1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 NCOR1 FBXW11 CSNK1D UBA52 CUL1 CHD9 EP300 RPS27A UBB;UBC CPT1A TBL1XR1 MEF2C KMT2A CRTC2 CRTC3 RAI1 TPTEP2-CSNK1E;CSNK1E MEF2D HELZ2 RBX1 NPAS2 CDK5 TGS1 RORA RXRA CARM1 PPARA NAMPT RORC RORB SMARCD3 HDAC3 ARNTL CSNK2A2 NRIP1 CRTC1 CIPC TFEB PER2 PER1 DBP NR1D1 BHLHE40 CSNK2B CRY2 CRY1 SIK1;SIK1B RBM4;RBM4B UBE2D1 F7 AVP BHLHE41 KLF15 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 CYP11B1;CYP11B2 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors KCNJ2 KCNJ12;KCNJ18 KCNJ3 KCNJ4 GNG10 GABBR2 GNG2 KCNJ5 GNG5 GABBR1 ADCY9 GNG4 KCNJ6 KCNJ10 GNG8 KCNJ9 ADCY4 ADCY3 KCNJ15 KCNJ16 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 GNB2 GNB1 GNAL GNB4 GNB3 GNGT1 GNB5 GNAT3 GNAI1 GNAI3 GNAI2 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation CALM3;CALM1 PDE1C PDE1B PDE1A REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPO ARNT VEGFA HIF1A CREBBP CITED2 EP300 CA9 EPAS1 HIGD1A C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen FGG FGB FGA PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation PIP4P1 TP53 PIP4K2A PIP4K2B PIP4K2C MAP2K6 PIN1 EP300 ING2 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways PDCD6IP LTF EPCAM TLR2 STX1A PDZD3 UPK1A GBP2;GBP3;GBP1 B2M PGK1 CDH1 KPNB1 SH3GL3 SH3GL1 ENO1 CASP5;CASP4 GSK3A HSP90AB1 TRIM27 SNAP25 SRC HBD;HBB GBP7;GBP4 HBA2;HBA1 RAB5A STAM2 GUCY2C MRC1 MET CTNND1 CBLL1 CTSG EPS15 SFPQ-1 CTNNB1 KPNA1 HSP90AA1 EEF2 TXNRD1 NOS2 HGS ATP6V1H CALM3;CALM1 CORO1A RAB7A GBP6 HBEGF STAM DUSP16 UBE2D3;UBE2D2 UBA52 CBL SYT2 SYT1 VAMP2 FURIN VAMP1 SH3GL2 SV2C SV2B SV2A SH3KBP1 CD9 RNF213-2 RPS27A UBB;UBC MAP2K2;MAP2K1 MAPK1 MAP2K4 MAPK3 VPS33B MAP2K7 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 AXIN2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 TNKS TNKS2 RNF146 PSMA7 PSMD8 AXIN1 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 SMURF2 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD HSPG2 BCAN VCAN GPC6 CSPG5 AGRN SDC1 DCN GPC1 SDC4 GPC3 B3GAT3 SDC2 GPC2 NCAN SDC3 GPC5 BGN GPC4 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance DSCC1 CHTF18 BLM CTC1 STN1 TEN1 ACD TINF2 ATRX TERF2 CCNA2-1 POT1 CCNA1 TERF2IP TERF1-1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLD1 POLR2C POLR2D H2BC21 POLR2G POLR2I DAXX PRIM2 PRIM1 H2AC20 WRAP53 POLA1 POLA2 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 DNA2 RFC5 RFC3 RFC4 RFC2 DKC1 NHP2 H2AJ PPP6C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TERT POLR2E PPP6R3 LIG1 POLR2F POLR2H POLR2L RFC1 H2BC15;H2BC3;H2BC11;H2BC12 ANKRD28 H2BC5 NOP10 PCNA WRN H2BC1 PIF1 SHQ1 RPA1 RPA2 CDK2 POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 POLD2 RPA3 FEN1 H2AC4 RUVBL2 RUVBL1 RTEL1 H2AC14 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling ABL2 SOS1 FLT3LG PIK3CA PTPN11 BCL2L11 GRB10 CDKN1B AKT2 GRAP2 AKT3 GAB2 PTPRJ FOXO3 FLT3 SOCS2 AKT1 UBA52 CBL LCK STAT5A STAT5B SLA2 RPS27A SYK SH2B3 UBB;UBC HCK CSK HRAS SLA PIK3R1 FYN SOCS6 NRAS LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD DLD BCKDHA DBT BCKDHB DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 PROC F5 PROS1 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones MBTPS2 ATF4 NFYA-1 NFYB DDIT3 NFYC ATF6 CALR-1 HSPA5 HSP90B1 MBTPS1 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia RBX1 CA9 VEGFA CREBBP CITED2 HIF3A PSMD12 PSMD11 PSMD14 PSMD13 EPO PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 HIF1AN PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ARNT HIF1A ADRM1 PSMC2-1 VHL PSMA2-1 PSMA5 CUL2 LIMD1 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 UBE2D3-1 PSMC3 PSMA1 PSMC4 PSMC1 AJUBA UBE2D3;UBE2D2 UBA52 EPAS1 UBE2D1 EGLN1 EGLN3 EGLN2 EP300 RPS27A WTIP HIGD1A UBB;UBC ELOC-1 ELOB DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 NUS1 DHDDS RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 RPL10;RPL10L-1 PSMB7 PSMD6 RPS25 RPS27 PSMB4 PSMD7 RPS29 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 UBE2D3-1 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 ANKZF1 KLHDC10 NPLOC4 TCF25 UFD1 NEMF RPL18A FAU RPL12-1 VCP-1 RPS27A UBB;UBC RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RBX1 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ZNF598 ASCC2 RPL8 ASCC3 LTN1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 ABCE1 UBE2D3;UBE2D2 UBE2D1 RPL23A ELOC-1 RPL11 RPL14 RCHY1 ELOB RPL13 RPL18 RPL17 RPL19 RPS15 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function CDH8 CTNND1 ADAM19 JUP ANGPTL4 CDH24 CDH11 CTNNB1 ADAM33 CTNNA1 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling RPS14 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 RPS17 RPS16 RPS19 IFNGR1 TRIM46 IFNGR2 TRIM45 RPS18 GBP2;GBP3;GBP1 TRIM35 TRIM38 TRIM31 RPS11 B2M TRIM29 RPS10 TRIM26 RPS13 RPS12 TRIM14 TRIM10 EIF3C;EIF3CL EIF1AY;EIF1AX VCAM1 IRF4 EIF3M EIF3K EIF3L EIF3I EIF3J IRF8 EIF3G SFN EIF3H EIF3E SNCA EIF3F EIF3D EIF3A DNAJC3-1 EIF3B PGGT1B RPS25 RPS27 CASP1 RPS29 RPS20 RPS21 RPS24 RPS23 PLCG1 IFIT1 IFIT3 JAK1 IFIT2 PPP2R1A TYK2 MX1-1 HSPA1L SKP1 RPS27L ILF2 RPS15A RAF1 RPS3 HSPA1A;HSPA1B IFIT5 UBA52 RPS2 NUP214 PRKCD STAT1 STAT2 CUL1 OASL OAS1 FAU OAS3 RPS27A UBB;UBC KPNA2 IRF5 RPS9 HSPA8 RPS7 RPS8 RPS5 RNASEL RPS6 FLNB EIF4G1 RPSA CDK1 PTPN2 EGR1 IFI35 STAT3 RSAD2 IFNAR1 SAMHD1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IP6K2 MAVS MID1 JAK2 ISG20 UBE2N IRF6 IRF9 RPS4X IRF1 RPS3A IRF2 KPNA4-1 IRF3 TRIM8 TRIM6 TRIM5 TRIM2 IRF7 TRIM3 BECN1 FNTA FCGR1A EIF4A2 EIF4A1 NCAM1 FLNA IFNB1-4 USP18;USP41 PTPN11 NUP107 NUP188 EIF4E2 PDE12 KPNA1 EIF2S2 EIF4E SP100 EIF2S3;EIF2S3B NUP210 DHX9 EIF2S1 BST2 NUP93 NUP205 ABCE1 AAAS NUP160 NUP85 CD44 TPR NUP88 NUP155 FURIN NUP153 IFNG SPHK1 NUP62 MT2A NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 NUP42 NCK1 SOCS1 NUP43 DUS2 RAE1 RANBP2 FAAP24 LOC105377022;FANCB FAAP100 CENPX NUP35 FANCM FANCL FANCA FANCE FANCG FANCF NUP37 TARBP2 PRKRA FNTB;CHURC1-FNTB CHUK UBA7 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 IFI44L HERC5 IFIH1 IKBKB TRIM25 GBP6 ARIH1 IKBKG ATF6 FKBP5 SOCS3 PTPN1 TRIM21 PPP2CB;PPP2CA ILF3 PIM1 PPP2R5A KPNA7 KPNA5 KPNA3 PPP2R1B ADAR PPM1B EIF4A3 NPM1-2 MAP2K6 ACTB-1 FANCC KPNB1 NEDD4 UBE2I HSPA2 PIN1 PIAS1 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 SUMO1 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ACTG1 HLA-DRA GBP7;GBP4 TP53 SMAD7 PSMB8 YBX1 CAMK2B CAMK2D CENPS-CORT;CORT;CENPS CAMK2A CAMK2G PML PTPN6 EIF4G3 EIF4G2 EIF4E3 PTAFR IFITM3;IFITM2;IFITM1 UBE2E1 EIF2AK2 MAPK1 MAPK3 GBP5-1 CIITA IFI30 TRIM68 ICAM1 RPS15 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 EEF1A1 EEF2 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal MGMT ALKBH2 FTO ALKBH5 ALKBH3 ASCC1 ASCC2 ASCC3 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RPS14 RPS17 TBK1 RPS16 RPS19 RPS18 NPM1-2 RPS11 BCL2L1 TKFC PCBP2 RPS10 IRAK2 RPS13 RPS12 NLRP3 KPNB1 CAV1 UBE2I MAVS SP1 RIPK3 SFN SMAD2;SMAD3 ITCH RPS4X YWHAQ YWHAH PDPK1 RPS3A PYCARD FKBP1A IRF3 RPS25 CASP1 TRAF3 RPS27 PPIA SMAD4 RPS29 TRAF6 RPS20 RPS21 RPS24 RPS23 YWHAE IFIT1 IKBKE IFIT3 IFIT2 TOMM70 SFTPD HNRNPA1-1 PSMC6 YWHAG EEF1A1 SIKE1 PPIB DDX58 TLR7 BST2 RUNX1 RPS27L IFIH1 RPS15A TRIM25 YWHAB RPS3 RCAN3 UBA52 NFKBIA RPS2 PPIH PPIG YWHAZ MPP5 RELA STING1 NMI FAU EP300 RPS27A KPNA2 UBB;UBC NFKB1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog ULK3 DZIP1 SPOPL P4HB SPOP IHH PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 GRK2 PSMB6 PSMB7 PSMD6 PSMB4 HHIP PSMD7 BOC PSMB5 GAS1 PSMB2 CDON ARRB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKACA-1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CDC73 DHH GPC5 UBA52 CUL1 PRKAR2B VCP-1 RPS27A SYVN1 DERL2 UBB;UBC OS9 EVC2 EFCAB7 OFD1-1 EVC GAS8 IFT172 GLI1 GLI3 GLI2 IFT52 IFT57 DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 RBX1 GNAS-1 IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 NUMB INTU ADCY4 ADCY3 TULP3 GSK3B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 WDR19 IFT122 FUZ ADAM17 ADCY10 ITCH MKS1 SHH SMURF2 ERLEC1 SMURF1 HHAT CUL3 ARRB1 DISP2 SCUBE2 NOTUM CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects PDE11A PRKG2 ITPR1 PDE10A KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 PDE9A PDE5A PDE1B PDE1A PDE2A IRAG1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection C3-1 TXN CTSG HMOX1 NLRP3 HSP90AB1 RELA MEFV NFKB2 PYCARD NT5E P2RX7 PSTPIP1 C3AR1 IL18 CASP1 IL1A IL1B TXNIP P2RX4 SUGT1 NFKB1 GSDMD ENTPD1 ENTPD5 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSME1 PSMB1 PSMD1 PSMB10 PSMB8 ADRM1 PSMB9 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PSME2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors HSPH1 MASP1 SAA2;SAA1 HPX APOB APOA1 APOL3;APOL4;APOL1;APOL2 AMBP LRP1 JCHAIN HSP90AA1 HMGB1-1 COL1A1 CD5L COL1A2 STAB1 CD163 SSC5D COL3A1 STAB2 FTH1 CALR-1 SCARF1 HBD;HBB HP;HPR HYOU1 HBA2;HBA1 ALB PRDX1 SPARC CD36 COLEC12 APOE MSR1 COLEC11 FTL-1 SCARA5 HSP90B1 COL4A2 MARCO COL4A1 SCGB3A2 S100A9 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L WDR5 DPY30 RBBP5 KMT2D S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase ESCO1 ESCO2 AKT2 AKT3 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 CDC25B PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 PSMB6 DNA2 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 E2F1 PSMA2-1 ORC1 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 CDCA5 PDS5B PDS5A WAPL PCNA AKT1 UBA52 CUL1 RPA1 PTK6 RPA2 CDK4 CDK2 RPA3 RPS27A UBB;UBC RBX1 CDK7 MNAT1 GSK3B POLD1 CKS1B RFC5 RFC3 RFC4 RFC2 RBL2 CABLES1 WEE1 SMC3 MYC RAD21 STAG1 STAG2 SMC1A RBBP4 MAX CCND1 LIG1 POLE RFC1 LIN54 LIN37 LIN9 LIN52 ANAPC15 ANAPC16 UBE2D1 GINS1 GINS2 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 POLD3 GINS3 CDC26 GINS4 CDC27 MCM3 POLD4 MCM4 POLD2 ANAPC7 MCM5 E2F5 MCM6 UBE2C MCM2 POLE4 UBE2E1 FEN1 UBE2S CDC16 CCNE2 ANAPC4 POLE2 CCNE1 ANAPC5 RB1 ANAPC1 POLE3 ANAPC2 CCNH ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX BAX BID PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling PTPN11 CUL1 STAT5A BTRC RBX1 STAT5B PRL PRLR SKP1 GHR JAK2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling PIK3CA MTOR PIK3R3 CD28 PIK3R6 PIK3R5 AKT2 AKT3 CD86 CD80 AKT1 THEM4 RICTOR PRR5 LCK PDPK1 MLST8 TRIB3 MAP3K14 PIK3CD MAPKAP1 PIK3CG PIK3R2 PIK3CB MAP3K8 PIK3R1 FYN POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events CDC25A PKMYT1 CCNB2 CCNB1 RBBP4 MYBL2 EP300 CENPF FOXM1 LIN54 WEE1 LIN37 PLK1 LIN9 LIN52 CDC25C HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism CARNS1 UROC1 CARNMT1 HNMT FTCD AOC1 HAL AMDHD1 HDC SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases USP8 ATXN7 CDC20 CCNA2-1 CCNA1 IDE USP33 USP5 H2BC18 USP3 FKBP8 SNX3 USP37 USP34 USP47 PSMD12 USP48 USP49 TAF9B PSMD11 USP42 USP22 PSMD14 USP44 CDC25A PSMD13 ADRB2 SMAD2;SMAD3 PTRH2 USP26;USP29 USP16 WDR20 H2AC20 PSMA7 USP24 USP25 PSMD8 USP20 TAF10 USP28 TOMM20 PSMB6 PSMB7 VDAC2-1 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 VDAC3 ARRB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 TOMM70 ADRM1 CCP110 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 USP21 PSMC6 USP4 PSMA4 PSMC3 CYLD PSMA1 PSMC4 PSMC1 BIRC2 BIRC3 KAT2A CFTR DDX58 IFIH1 AXIN2 IKBKG DDB2 H2BC5 UBA52 H2BC1 KEAP1 UFD1 AXIN1 RPS27A RNF123 H2AC4 UBB;UBC MAP3K7 CLSPN VDAC1 SIAH2 USP7 USP2 MDM2-2 SUDS3 MAT2B GATA3 IL33 TADA3 RHOT1 POLB USP30 USP15 MDM4 TAB1 H2BC21 USP10 USP13 AR TNKS TNKS2 RNF146 PTEN SMAD1 SMAD4 SMURF2 TRAF6 TP53 SMAD7 BECN1 HIF1A MYC STAM2 USP18;USP41 USP9X TRRAP TRAF2 FOXO4 USP14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIPK1 HGS TADA2B H2BC15;H2BC3;H2BC11;H2BC12 RNF128 NFKBIA OTUB1 ARRB1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RCE1 H2AC16;H2AC11 TGFBR1-1 MUL1 RUVBL1 WDR48 H2AC14 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS MUC17 C1GALT1C1 C1GALT1 MUC5B MUC20 MUC21 MUC12 MUC15 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC6 MUC13 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events PDE3B AKT2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCG5 ABCD2 APOA1 PEX3 ABCD3 ABCD1 ABCG4 ABCA6 ABCA2 ABCA5 ABCA9 ABCA7 ABCA12 PEX19 ABCG1 ABCA3 ABCG8 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation DGKZ PLA2G4A SOS1 GNA13 DGKQ DGKK DGKI PIK3R3 DGKH ABHD6 PIK3R6 PIK3R5 MGLL PDPN MPIG6B GP6 DAGLA STXBP3 STX4 DAGLB FCER1G P2RY1 APP EGF RAP1B HGF AAMP AHSG PRKCE APOA1 LAMP2 RAF1 TUBA4A AKT1 STXBP2 PRKCD RAPGEF3 PRKCA RAPGEF4 YWHAZ VWF MAPK14 PRKCB CYB5R1 TF CLEC1B PDGFB PRKCZ ORM2;ORM1 SELP QSOX1 LCP2 CD63 TBXA2R GNA12 A1BG PDPK1 FN1 IGF1 SERPINA3 CDC42 GNAT3 SYK A2M GNAI3 SERPINF2 FYN HRG FLNA CFD PTPN11 TIMP1 PLCG2 SERPINA1 CALM3;CALM1 ACTN2 CFL1 ARRB1 GNGT1 PLG SOD1 CD9 APBB1IP GAS6 TTN-1 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 CAP1 GNG13 VEGFA GNAQ CD109 GNB2 RAB27B GNB1 PRKCG GNB4 GNB3 ITPR1 ITPR2 GNB5 LCK ITPR3 TLN1 SRC ISLR HABP4 CHID1 PSAP GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 ARRB2 SERPINE1 LY6G6F;LY6G6F-LY6G6D ALB ENDOD1 GNAI1 APOH PECAM1 CSK SPARC VTI1B GNAI2 MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 PCDH7 CTSW TIMP3 ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD ADRA2C LHFPL2 PCYOX1L ADRA2A FAM3C ACTN1 LEFTY2;LEFTY1 APLP2 TMX3 RAC1 SELENOP SCG3 PFN1 HSPA5 RARRES2 CYRIB SCCPDH RHOA LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CRK CDC37L1 PTK2 BRPF3-1 PPBP ITGA2B PTPN1 BCAR1 ABCC4 P2RY12 VAV3 PF4;PF4V1-1 RHOG VAV1 VAV2 RHOB TGFB2 TGFB3 MMRN1 APOOL MPL THPO ADRA2B ACTN4 GP1BA VCL IGF2 LAT PPIA PIK3CG PIK3R2 PIK3CB TRPC7 PIK3R1 ALDOA TRPC6 PRKCH TRPC3 THBS1 PIK3CA PTPN6 TGFB1 SHC1-1 PRKCQ ITGB3 PROS1 RASGRP2 F13A1 RASGRP1 LYN FGB FGA GP1BB F2R FGG F2 F5 F8 SERPING1 CLU KNG1 F2RL2 F2RL3 DGKG GP5 DGKE GP9 DGKD DGKB RAP1A DGKA MAPK1 MAPK3 ABHD12 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g ALG12 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) CDK6 STAT3 CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 CDKN2D CDKN2C H2AC20 H2AB2;H2AB3;H2AB1 IGFBP7 H2AZ2;H2AZ1 IL1A JUN CXCL8 MAPK7 CDKN1A CDKN1B H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FOS H2BC15;H2BC3;H2BC11;H2BC12 CDKN2B H2BC5 UBA52 H2BC1 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 CDK4 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A CDKN2A RPS6KA3 UBE2C UBE2E1 RPS6KA2 H2AC4 UBB;UBC NFKB1 RPS6KA1 IL6 UBE2S CDC16 ANAPC4 MAPK1 ANAPC5 ANAPC1 MAPK3 ANAPC2 EHMT2 EHMT1 H2AC14 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders HDAC1 CALM3;CALM1 CAMK4 TBL1XR1 GPS2 NCOR2 NCOR1 SIN3A PRKACA-1 HDAC3 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines TBK1 STAT6 STING1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation FGF20 FGF23 FGF1 FGF4 FGF16 FGF9 FGF2 GALNT3 FGF18 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins MET ITGB1 TNS4 TNS3 HGF SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer CBL GAB1 SOS1 PIK3CA HSP90AA1 RPS27A UBB;UBC EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS UBA52 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane MTMR2 PI4KA SACM1L PI4K2B SBF1 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling CDK1 PTPN2 STAT3 NPM1-2 MAP2K6 FANCC UBE2I MAVS NCK1 HSPA2 DUS2 SNCA SUMO1 DNAJC3-1 FAAP24 LOC105377022;FANCB FAAP100 CENPX TP53 FANCM FANCL FANCA FANCE FANCG FANCF TARBP2 CENPS-CORT;CORT;CENPS PRKRA PPP2R1A HSPA1L CHUK EIF2S2 EIF2S3;EIF2S3B DHX9 EIF2S1 ISG15 UBE2L6 HERC5 ILF2 IKBKB TRIM25 ARIH1 HSPA1A;HSPA1B IKBKG STAT1 PPP2CB;PPP2CA ILF3 PPP2R5A PPP2R1B SPHK1 HSPA8 EIF2AK2 ADAR REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function SOX10 CDH19 ZC3H12A CTNND1 JUP CTNNB1 CTNNA1 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling TGFA PIK3R3 GNG10 BCL2 GNG2 AKT2 GNG5 NOS3 STRN AKT3 GNG4 GNG8 PRKCZ CAV1 GNG13 GNB2 GNB1 ESR1 GNB4 GNB3 ZDHHC21 GNB5 PDPK1 SRC SRF GNAT3 PIK3R2 EGF ESR2 GNAI1 HRAS GNAI3 EGFR GNAI2 PIK3R1 PRMT1 NRAS PIK3CA AREG CDKN1B HSP90AA1 FOXO3 CCND1 MMP7 MMP2 EREG MMP3 BTC CALM3;CALM1 MMP9 S1PR3 ZDHHC7 FOS HBEGF CAV2 IGF1R XPO1 UHMK1 PTK2 EPGN AKT1 GNGT1 ELK1 SPHK1 MAPK1 MAPK3 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL TDGF1 LEFTY2;LEFTY1 ACVR1B CFC1;CFC1B CER1 DAND5 ACVR1C NODAL ACVR2B ACVR2A DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG MTR-1 MTRR MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing NCBP1 TRA2B PHF5A SNRPD2 PAPOLA SNRPD1 SNRPN SNRPD3 DNAJC8 POLR2A FIP1L1 POLR2B POLR2C POLR2D SRRM2 POLR2G SNRPE-2 POLR2I CSTF3 CSTF2 NCBP2-1 HNRNPH2 RBBP6 PTBP1 PPP1CB HNRNPH1 CPSF4 HNRNPA1-1 CPSF1 CPSF3 HNRNPM PPP1CA RBM5 SF3B1 RBMX UBA52 SRRT RPS27A UBB;UBC SNRPF U2AF1L5;U2AF1 CCAR1 EIF4A3 CASC3 SNRPB THOC1 DDX5 THOC3 PCBP1 THOC2 PCBP2 THOC5 SYMPK CDC40 RBM10 THOC7 THOC6 SRRM1 DDX39A DHX15 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF5 HNRNPC SRSF6 TCERG1 SLU7 SRSF7 SRSF9 RBM8A POLDIP3 SRSF1 U2AF2 FYTTD1-1 DDX46 DHX38 DDX42 SRSF11 RBM17 MAGOH;MAGOHB SRSF4-1 HTATSF1 CHTOP ALYREF UPF3B RNPS1 PPP1R10 CSTF2T CPSF2-1 PRPF40A SMNDC1 U2SURP TUT1 NUDT21 CLP1 SRSF10 SRSF12 YBX1 FUS PAPOLG SNRPG-2 HNRNPA3 SF3B4 SF3B5 SNRPC SF3B2 SNRPA SF3B3 PPP1R8;STX12 SF3B6 SF3A3 SF3A1 SF3A2 POLR2E DHX9 CPSF7 POLR2F GTF2F1 POLR2H GTF2F2 SUGP1 RBM25 PABPN1-1 POLR2L CHERP SNRNP70 PUF60 RBM39 SNRPB2 HNRNPF POLR2J;POLR2J2;POLR2J3 HNRNPA2B1 HNRNPU HNRNPR SNRPA1 PCF11 HNRNPL XRN2 HNRNPK HNRNPD WDR33 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport SLC16A8 SLC16A3 BSG SLC16A1 SLC16A7 EMB PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL PLA2G4A PPP2R1A PTPN11 PTPN6 PPP2CB;PPP2CA APOB PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B FGR PPP2R5E PECAM1 MAPK14 LRP8 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing TRA2B SNRPD2 SNRPD1 SNRPD3 SNRPE-2 PTBP1 HNRNPH1 HNRNPA1-1 HNRNPM RBMX HSPA8 ZCRB1 SNRPF SNRPB DDX5 HNRNPC TCERG1 GPATCH1 PNN CXorf56-1 ZNF830 SF1 DHX8 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PRPF38A SMU1 NKAP UBL5 PRPF40A GCFC2 PRPF18 SDE2 FAM32A CACTIN SRSF10 SRSF12 PRPF31 PDCD7 RBMX2 FUS SNRPG-2 SNIP1 SNRNP35 IK BCAS2 PRPF4B LENG1 PRPF4 PRPF3 HNRNPA3 SNRNP27 GPKOW SNRNP25 CDC5L SNRPC SNRPA PPP1R8;STX12 ZMAT2 ZMAT5 CCDC12 YJU2 LSM5 LSM4 DHX9 LSM3 LSM2 GTF2F1 LSM8 GTF2F2 LSM7 SUGP1 LSM6 RBM25 NSRP1-1 PPWD1 DDX41 USP39 SART1 SNRNP70 TFIP11 SYF2 LUC7L3 PPIE C9orf78 PPIH WBP4 PPIG ZRSR2-1 RNF113A RBM39 PPIL2 MFAP1 ACIN1 RBM42 BUD13 HNRNPF SNRNP48 HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 FAM50A HNRNPU HNRNPR SNRPA1 HNRNPL HNRNPK HNRNPD ISY1;ISY1-RAB43 NCBP1 PHF5A TXNL4A SNRPN PLRG1 DNAJC8 POLR2A POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 SRRM2 POLR2G POLR2I CRNKL1 NCBP2-1 HNRNPH2 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 SNW1 CWC15 RBM5 SF3B1 PQBP1 SRRT MTREX SNRNP200 CTNNBL1 PRCC CCAR1 U2AF1L5;U2AF1 EIF4A3 CASC3 PCBP1 PCBP2 CDC40 RBM10 SRRM1 DHX15 DDX39B DHX16 SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 WBP11 RBM8A SRSF1 U2AF2 DDX46 DHX38 DDX42 SRSF11 MAGOH;MAGOHB RBM7 RBM17 SRSF4-1 BUD31 ALYREF RBM22 UPF3B RNPS1 DDX23 SMNDC1 U2SURP YBX1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 POLR2E SAP18 POLR2F POLR2H POLR2L CHERP PUF60 SNRPB2 AQR PRPF19 EFTUD2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) DRP2 DMD UTRN LAMC3 SGCE SGCD SGCA SGCB HSPG2 LAMA5 SGCG SNTA1 LAMA3 LAMA2 LAMA4 DAG1 LAMB3 LAMB2 AGRN SGCZ LAMB1 SNTB1 LAMA1 SNTB2 DTNA LAMC2 DTNB LAMC1 SSPN ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B1;HSD3B2 SRD5A2 LHB HSD17B12 SRD5A1 SRD5A3 CYP17A1 CGA HSD17B3 POMC DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells LAMA5 LAMA3 LAMA2 LAMA4 FN1 LAMB3 LAMB2 LAMB1 VTN LAMA1 EGF LAMC3 LAMC2 LAMC1 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants FLT3 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP POLB NEIL1 NEIL2 LIG3 OGG1 XRCC1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP1BA GP5 GP9 ADAMTS13 VWF GP1BB VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 FGF20 SOS1 FGF23 FGF2 FGF7 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 APP NFKB2 TRAF6 TLR5 TP53 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER S100A12 N4BP1 JUN PPP2R1A USP18;USP41 MYD88 MAPK7 NFKBIB SAA2;SAA1 NKIRAS1 BTRC NKIRAS2 IKBIP IRAK4 ECSIT SKP1 TRAF2 PELI1 CHUK CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 FBXW11 TIFA HMGB1-1 MAP3K1 IKBKB IKBKG FOS UBA52 NFKBIA CUL1 MAPKAPK2 RELA TLR10 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling EREG BTC PIK3CA NRG3 NRG4 PIK3R1 HBEGF NRG1 NRG2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) ATM TP53BP1 RAD50 PRKDC BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 LIG4 PAXIP1 BABAM1 BABAM2 PIAS4 UIMC1 ABRAXAS1 RNF8 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 BRCC3 H2BC15;H2BC3;H2BC11;H2BC12 MDC1 UBE2N H2BC5 H2BC21 H2BC1 DCLRE1C KAT5 RIF1 POLL NHEJ1 XRCC6 POLM XRCC4 TDP2 HERC2 XRCC5 TDP1 NSD2 MRE11 UBE2V2 NBN BARD1 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 POLR1C POLR1D CRCP LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 DLD BCKDHA DBT BCKDHB COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism MTR-1 MMADHC MTRR MMAA MMAB MMACHC MMUT DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins NUP133 BLM NUP50 POM121;POM121C NUP54 BMI1 PIAS4 RING1 NUP42 UBE2I MDC1 NUP43 PARP1 PIAS1 RNF2 HDAC7 RAE1 RANBP2 CBX8 SUMO1 SUMO3 SUMO2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 SMC5 CETN2 NUP37 SMC6 SMC3 NSMCE3 RAD21 NSMCE2 NSMCE1 STAG1 EID3 STAG2 SMC1A PML NUP107 NUP188 BRCA1 NSMCE4A TDG SP100 NUP210 RNF168-1 NUP93 RAD52 NUP205 AAAS PCGF2 NUP160 WRN NUP85 NUP214 TPR NUP88 NUP155 XRCC4 RPA1 HERC2 NUP153 XPC CDKN2A NUP62 NDC1 SEC13 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease DPM1 DPM2 DPM3 PDZD3 DNAJC10 ELAVL2 UPK1A GBP2;GBP3;GBP1 CSNK2A1;CSNK2A3 RPL10A S1PR1 PPP1CC VIM PLCG1 RAB5A EGFR RPL36AL-1 YWHAE PPP1CB PRKACA-1 PRKG2 NEK2 BTRC YWHAG APOA1 SKP1 HSP90AA1 CDC73 LEO1 UBA52 DYNC1I2 PRKAR2B RPL18A RPS27A ELK1 UBB;UBC DYNC1H1 MAP2K4 MAPK8 MAP2K7 TUBB4A;TUBB;TUBB8B;TUBB8 TXN BCL2L1 CDH1 HSPG2 ADAM17 NT5E ACOT2;ACOT1 COMT CTSG RPL15-1 CTSV;CTSL MMP9 ITGA4 FURIN RB1 CCNH H2AC14 TRIM28 MED1 YES1 MED4 MED6 MED7 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SMAD2;SMAD3 H2AC20 EZH2 RPL10;RPL10L-1 MED16 MED17 MED12 MED14 MED13 MED10 MED27 ARF1 MED23 RPLP0 NCOR2 NCOR1 RPLP2 MED24 TAL1 RPL36-1 MED20 GPS2 SF3B1 MBD3 SUZ12 H2BC5 H2BC1 GTF2H1 GTF2H3 VAMP2 GTF2H4 GATAD2B GATAD2A MED31-1 ARID4B EP300 NRBP1 H2AC4 SAP30 TBL1XR1 MED30 ABL1 SUDS3 RPL22L1 CDK8 CDK7 ACTB-1 RPL37A-1 MNAT1 GSK3B KPNB1 PSIP1 CHD4 CHD3 H2BC21 PARP1 TBP EED SMAD4 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CAMK2B CAMK2D HDAC2 CAMK2A RPL13A-1 HDAC3 SLC25A4 HDAC1 CAMK2G MTA1 RBBP4 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L PROS1 H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 F2 CLU RPL23A AHCYL1 EIF2AK2 PRKX ENTPD1 TLR1 ENTPD5 LTF TLR2 STX1A CD4 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 WASL IPO5 GRSF1 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 IFIT1 IFIT3 ADRM1 IFIT2 VPS36 SNF8 VPS25 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 ATP1B2 ATP1B1 GGT1 DPEP2 DPEP1 YWHAB HSPA1A;HSPA1B ELAVL1 XPO1 AKT1 NUP214 GGT5 YWHAZ XRN1 FXYD4 FXYD3 FXYD1 HSPA8 PABPC1;PABPC3 FXYD6 MAPK14 EIF4G1 RBX1 GNAS-1 ADCY9 ATP1A4 ATP1A3 PRKAR1B PRKAR1A ATP1A2 ATP1A1 ADCY4 RPL26L1 ADCY3 ADCY2 RPL4 ADCY1 ADCY8 RPL30 ADCY7 RPL3 ADCY6 RPL32 ADCY5 PRKACB-1 ATP1B3-1 RPL31 FXYD2;FXYD6-FXYD2 RPL34 PRKAR2A ENO1 CSNK1A1 RPL8 RPL9 RPL6 ITCH RPL7 RPL35 RPL38 FKBP1A CD3G RPL39 CYSLTR1 CYSLTR2 GNAT3 SYK FGR RPL21 HCK ADORA2B RPL23 GNAZ GNAI3 RPL22 MED8 FCGR3A;FCGR3B FYN MED9 FCGR1A CUL3 RPL24 RPL27 RPL26 RPL29 C3-1 RPL28 NFKBIB CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 PLCG2 BANF1 TLR9 KPNA1 SUPT16H NUP210 CDK19 LIG1 LIG4 RPL3L GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L RPLP1-2 AAAS GTF2E1 GTF2E2 NUP160 NUP85 CLINT1 TPR NUP88 AP1G1 SUPT4H1-1 XRCC6 AP1S2 NUP155 AP1S1 XRCC4 AP1S3 XRCC5 VTA1 NUP153 AP1B1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 RAB5C CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 RPL11 ELOA RPL14 AP1M2 NELFB ELOB RPL13 NELFCD RPL18 AP1M1 NELFA RPL17 CCR5 RPL19 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B ITPR1 POLR2I RAE1 ITPR2 WNT5A RANBP2 ITPR3 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 FZD7 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 RPL7A CHUK UBA7 HSPA5 DDX58 TXNRD1 ISG15 RPL35A UBE2L6 HERC5 IFIH1 IKBKB IMPDH1 TRIM25 IMPDH2 ARIH1 IKBKG CLTC CLTA AP2A1 AP2B1 KEAP1 AP2A2 AP2S1 SH3GL2 ATG7 ITGB1 SCAP PIK3R1 CUL5 UBA6 UBA5 JAK3 UBR4 PTPN6 TGFB1 RUNX1 UBA3 UBA1 RELA RNF213-2 NFKB1 IL6 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN RIPK3 ST3GAL1 ST3GAL2 ST3GAL3 VPS16 MEFV SRPK2 MLKL EDEM2 NFKB2 PARP16 PYCARD PARP14 P2RX7 SRPK1 PSTPIP1 PARP10 RPS25 RPS27 CASP1 TXNIP RPS29 SDC1 SUGT1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE JAK1 TOMM70 PARP6 PTBP1 PARP4 PRMT1 RIPK2 SFTPD HNRNPH1 ANO8 ANO9 HNRNPA1-1 ANO6 MET HNRNPM TYK2 ANO4 CTNND1 PARP9 IL17RC NFE2L2 ANO5 CBLL1 ANO2 EPS15 PARP8 IL17RA ANO3 MYO10 ANO1 EEF1A1 MYO5A SIKE1 MYO1C SMN2;SMN1 EEF2 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 GPC4 RPS2 MGAT2 GPC6 STAT1 KDM1A STAT2 SEC24D-1 MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 GSDMD RPS9 RPS7 RPS8 RPS5 VPS33A PHF21A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU RCOR1 IFNAR1 SNRPB DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG HMG20B CAV1 MAVS OSTC STT3A JAK2 UBE2N TAB3 TAB2 STT3B TAB1 GSK3A ST6GALNAC2 HSP90AB1 TRIM27 PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 C3AR1 IRF3 DOCK2 IL18 HBD;HBB DAD1 IL1A TRAF3 CDC42 IL1B MBL2-1 TRAF6 P2RX4 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB EIF4A2 SNRPG-2 EIF4A1 VHL GUCY2C CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 MGAT4B VPS45 SEC24C EIF4E NOS2 HGS CALM3;CALM1 ATP6V1H CORO1A PABPN1-1 RAB7A PAK2 IL10 GNGT1 HNRNPF HNRNPA2B1 SNRPA1 GNG10 GNG2 GNG5 GNG4 GNG8 CD163 PLK2 GNG13 RHBDF2 MYH9 GNB2 GNB1 GNB4 GNB3 GNB5 DAXX MAPKAP1 JUN SNW1 SFPQ-1 RAC1 RPTOR EXOC1 ELMO1 ELMO2 CRK DOCK1 HBEGF GBF1 CBL RICTOR NPLOC4 UFD1 FASN U2AF1L5;U2AF1 EIF4A3 NPM1-2 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 PRR5 DHX38 SRSF11 SRSF4-1 ALYREF MLST8 RNPS1 CBX1 FKBP4 PML MTOR TLR3 LY96 RIPK1 CD14 TLR4 LYN UBE2D3;UBE2D2 NFKBIA H2AC16;H2AC11 MAP2K2;MAP2K1 ARID4A MAPK1 MAPK3 SOS1 BRMS1 IFNGR1 IFNGR2 P4HB H2BC18 REST SLC25A5 SLC25A6 ROCK1 MED19 MED15 MED18 MED11 PPIB MED26 MED29 MED22 MED25 MED21 P4HA1 RBMX P4HA2 P4HA3 SYT1 CYFIP2 CYFIP1 NCKAP1 RPL12-1 WASF1-1 WIPF1 WIPF2 WIPF3 DYNC1LI1 DYNC1LI2 CD28 PGK1 NCKAP1L HNRNPC NOX1 CASP5;CASP4 SP1 ARPC1B ARPC1A SNAP25 KPNA4-1 HYOU1 CPSF2-1 ATL2 CRBN NUDT21 FNTA LY6E FUS NACA BCAS2 C1S HNRNPA0 HNRNPA3 GPKOW CDC5L PDCD1 DHX9 ABI2 BST2 TAOK1 SUGP1 ABI1 PEX19 IGF1R IL6R DNAJB11 PPIE PPIH PPIG SYT2 CD8B;CD8B2 SUN2 SV2C SV2B SV2A CD9 HNRNPU HNRNPR MAP1B WDR61 BTF3 HNRNPL HNRNPK HNRNPD DVL1 WDR33 DVL2 DVL3 GAS6 ISY1;ISY1-RAB43 EPCAM MED13L PHF5A ARPC4 AUP1 ARPC5 IPO7 PAPOLA TXNL4A ARPC2 SNRPN ARPC3 RAB5B NOXA1 NCL-1 PLRG1 DNAJC8 CEBPD CD33-1 FIP1L1 SEC11A NCK1 SEC11C SNRNP40 DNAJA2 ACTR2 PPIL3 PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 LCK CSTF3 CSTF2 CD79B ROCK2 CD79A SRC CHMP1A HNRNPH2 TLR6 EMC4 SPCS3 GNAI1 SPCS2 SPCS1 GNAI2 CWC25 PPIL1-1 WASF2 CWC27 WASF3 CWC22 PRPF6 BAIAP2 PRPF8 CPSF4 CPSF1 CPSF3 CWC15 FNTB;CHURC1-FNTB CGAS BLNK BTK RBM5 C4BPA C4BPB CLDN1 LOC110384692;C4A;C4B_2;C4B GBP6 STAM GRPEL1 PTK2 PQBP1 VAMP1 SRRT CALR-1 KPNA7 VAV3 KPNA5 KPNA3 SNRNP200 VAV1 VAV2 CTNNBL1 SIGMAR1 PRCC MERTK KDELR1 CCAR1 WAS TIMD4 NOXO1 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 PAF1 DYNC1I1 RETREG1 DHX15 DHX16 BCAP31 MYO9B UBE2I SH3GL3 SH3GL1 ZBP1 NR3C1 WBP11 HNRNPUL1 RTN3 DDX46 DDX42 SUMO1 RBM17 DYNLT1 BUD31 RBM22 ACTG1 DDX23 CSTF2T RRBP1 PPIA GBP7;GBP4 SMNDC1 U2SURP HBA2;HBA1 CLP1 CYBA TYRO3 STAM2 MRC1 SF3B4 SF3B5 CSNK2A2 SF3B2 NCKIPSD SF3B3 HMOX1 SF3B6 BRD4 DDX3X-1 SF3A3 SF3A1 SF3A2 XAB2 CSNK2B CPSF7 CLEC5A RPL5-1 VTN BAG2 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 DUSP16 CX3CR1 ACTR3-1 CLEC4M;CD209-2 PUF60 SNRPB2 AQR NMI SH3KBP1 PRPF19 MED28-1 PCF11 PACS1 MAPRE3 AXL HDLBP EFTUD2 PDIA3 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses TBK1 SIKE1 PPIB TKFC PCBP2 DDX58 IRAK2 TLR7 BST2 RUNX1 NLRP3 IFIH1 KPNB1 TRIM25 MAVS RCAN3 NFKBIA UBA52 PPIH PPIG RIPK3 ITCH RELA STING1 PYCARD NMI FKBP1A IRF3 CASP1 RPS27A TRAF3 PPIA TRAF6 KPNA2 UBB;UBC NFKB1 IFIT1 IKBKE IFIT3 IFIT2 TOMM70 SFTPD TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA NCBP1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 SLBP RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 NUP35 NUP62 NUP37 NDC1 SEC13 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UGP2 UGDH UXS1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions CLINT1 KDELR1 FURIN TSG101 YBX1 LYN GBF1 NCL-1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 HSPG2 BCAN VCAN GPC6 B3GALT6 CSPG5 AGRN SDC1 DCN GPC1 SDC4 GPC3 SDC2 GPC2 NCAN SDC3 GPC5 BGN GPC4 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT MAOA COMT LRTOMT TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1-1 TGFBR2 TGFB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy TBK1 VPS37C ULK1 VPS37D VPS37A VPS37B GABARAP CHMP3 CSNK2A1;CSNK2A3 CHMP6 CHMP7 MAP1LC3B2;MAP1LC3B-1 ATG14 PRKAB2 MVB12B MVB12A PIK3R4 HDAC6 PRKAB1 RRAGA RRAGC RRAGB MTMR3 CETN1 TOMM20 RRAGD TOMM22 VDAC2-1 MAP1LC3A FUNDC1 ATG9A UBAP1 ATG12-1 ARL13B VDAC3 WIPI1 TOMM40 ATG5 MTERF3 TOMM7 TOMM70 MTMR14 PRKAG2 ATM UBE2D3-1 PRKAG1 HSF1 EEF1A1 PRKAG3 HSP90AA1 RPTOR OPTN-1 CFTR LAMP2 PLIN2 UBA52 EPAS1 TSC2 TSC1 DYNC1I2 ATG3 ATG9B ATG10 ATG13 RNASE1 VCP-1 ATG101 RPS27A GFAP PCNT ATG16L2 LAMTOR2 ATG16L1 LAMTOR1 WDR45 UBB;UBC LAMTOR4 MAP1LC3C LAMTOR3 HSPA8 RB1CC1 LAMTOR5 WIPI2 VDAC1 ATG4C DYNC1H1 ATG7 ATG4B ATG4A ATG4D WDR45B AMBRA1 DYNC1LI1 DYNC1LI2 UBE2V1 IFT88 SLC38A9 PRKN DYNC1I1 UVRAG NBR1 RHEB PEX5 USP30 SQSTM1 UBE2N HSP90AB1 MLST8 HBD;HBB MFN1 MFN2 PIK3C3 BECN1 PARK7 PRKAA1 MTOR CSNK2A2 PRKAA2 CSNK2B CHMP4C CHMP4B CHMP4A VPS28 TSG101 UBE2D3;UBE2D2 PLIN3 CHMP2B CHMP2A PINK1 GABARAPL2 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins TLR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB123 DEFB121 ART1 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB130B;DEFB130A DEFB105A;DEFB105B CD4 DEFB103A;DEFB103B DEFB4A;DEFB4B DEFB1 DEFB109B CCR6 CCR2 PRSS3;PRSS2;PRSS1 DEFB131B;DEFB131A DEFB119 DEFA6;DEFA4;DEFA5 DEFB118 DEFB116 DEFB114 DEFB110 TLR1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs NCBP1 SNRPE-2 LSM10 SLBP ZNF473 LSM11 SNRPF SNRPB SNRPD3 NCBP2-1 SNRPG-2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import TIMM23 PMPCA TIMM13 CHCHD10-1 TIMM50 PITRM1 GRPEL2 TIMM8B DNAJC19 COA4 TIMM8A MTX2 TIMM44 GFER TIMM10B SAMM50 CHCHD7-1 CHCHD3 MTX1 ACO2 HSCB TOMM20 TOMM22 TIMM17A-1 CHCHD2 TOMM40 OTC TIMM22 TOMM7 TIMM10 SLC25A6 LDHD TOMM70 FXN SLC25A12 HSPD1 SLC25A4 ATP5F1A ATP5F1B CS SLC25A13 NDUFB8 IDH3G ATP5MC1 GRPEL1 HSPA9 CYC1 COX19 COQ2 TIMM21 BCS1L COX17 TAZ VDAC1 CHCHD4 CHCHD5 TIMM17B PMPCB CMC2 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport COG4 GJA1 COG3 PLA2G4A COG2 SPTBN2 BET1L RAB30 RAB36 AKT2 HPX AKT3 APOL3;APOL4;APOL1;APOL2 AMBP JCHAIN CTSC GJC1 ALPG;ALPP;ALPI-1 GJC2 GJA3 MAP1LC3B2;MAP1LC3B-1 AGPAT3 GJA10 CAPZA3 GJA5 STXBP3 ACTR10 GJA4 STX4 GJA9 GJA8 GJD2 GJD4 SAR1B GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GOLGA2 SFN DCTN6 DCTN5 DCTN4 APP RAB4A GRIA1 M6PR SYNJ2 NSF SCARB2 SYNJ1 AGFG1 EGF STON1-GTF2A1L KIAA0319 RAB5A EGFR TOR1A TOR1B YWHAE SYT9 SYT8 SNAP91 STON2 PIK3C2A SLC2A8 SLC18A3 SGIP1 EPN2 VAMP4 ACTR1A FCHO1 FCHO2 HSPH1 UBQLN1 REPS2 AREG REPS1 UBQLN2 NECAP2 EPS15 SYT11 YWHAG RAB8A APOA1 HSP90AA1 MYO5A OPTN-1 MYO1C CSNK1D RAB14 UBA52 PAFAH1B1 TSC2 AP4M1 DYNC1I2 TSC1 AP1G2 DCTN2 DNASE2 DCTN3 CLVS2 SEC24D-1 AP4S1 CLVS1 TJP1 KIF5B KIF5A MAN2A2 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A RPS27A KIF20B UBB;UBC KLC1 DYNC1H1 KLC4 COLEC12 KLC3 MSR1 KLC2 COLEC11 RACGAP1 SCARA5 HSP90B1 KIF3B MARCO SCGB3A2 KIF3C MASP1 KIF18A KIF18B ANK1 KIF12 MAN2A1 KIF11 KIF15 COL1A1 INS;INS-IGF2 KIF19 COL1A2 CAPZB KIF13B MAN1A2 KIF1C MAN1C1 KIF1B MAN1A1 KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 YWHAQ KIFC1 YWHAH KIF2C KIF2B SCARF1 HBD;HBB CENPE SEC23A KIF26A CAPZA1 KIF26B CAPZA2 USP6NL BICD1 SEC24B SCOC BICD2 SEC24A SYS1 GALNT2 PAFAH1B3 GCC1 GALNT1 PAFAH1B2 GOLGA1 ARFIP2 RINT1 KDELR2 VPS45 COPB2 SEC24C COPA ARL1 COPE USE1 RABEPK TMED3 TMED7 NAA30 TMED9 COPZ2 HGS COPZ1 CALM3;CALM1 NAA35 RAB7A NAA38 ARF5 NBAS TMF1 STX18 STX10 ARFRP1 VPS51 VPS53 VPS52 BNIP1 VPS54 ARCN1 COPG2 COPG1 RALA-1 VAMP7 DENND5B RABGEF1 RINL TBC1D10C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A ARFGAP1 TBC1D10B GABARAPL2 TRAPPC2L SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 TBC1D7;TBC1D7-LOC100130357 PREB RAB35 KDELR3 TBC1D24 TBC1D25 DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 TGFA RIN2 GABARAP TBC1D13 TBC1D14 TBC1D17 RAB6B CCZ1;CCZ1B TBC1D15 TBC1D16 TRAPPC3 TRAPPC1 GOSR2 ANKRD27 DENND4B DENND4A TRAPPC4 CD5L TRAPPC5 STAB1 CD163 DENND4C SSC5D HPS1 RAB39A HPS4 MYH9 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 CHRM2 MON1A MON1B DENND1C DENND1B ADRB2 GDI1 DENND1A ARF4-1 PRKAB1 GDI2 RAB8B DENND2D DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 RAB33A TRAPPC6A TBC1D2 TMED2-1 RABEP1 TRAPPC6B RAB7B RAB3IP ARF6 PRDX1 RAB1A RABGAP1 RAB1B RAB21 CD36 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB6A RAB33B-1 RAB11B RGP1 RAB10 RAB13 RAB18 RAB3GAP2 ARF1 RAB3GAP1 EXOC8 PRKAG1 EXOC7 CHM RAC1 PRKAG3 EXOC4 EXOC3 EREG EXOC6 BTC EXOC5 EXOC2 EXOC1 HBEGF GBF1 RAB11A CBL VAMP2 BIN1 SNX18-1 GJB2 RALGAPA2 GJB1 RALGAPB C2CD5 MIA2 MIA3 AMPH PACSIN2 PACSIN3 PACSIN1 TMEM115 TBC1D1 TBC1D4 GRK3 AGTR1 LRP1 LRP2 TACR1 F5 SLC2A4 COPS7B F8 COPS7A HP;HPR COPS3 COPS6 COPS5 COPS8 S100A9 SNAP29 APOB CD4 PRKAB2 WASL GRK2 PIP5K1C ANK3 IL7R VPS36 SNF8 EPS15L1 VPS25 EPN1 COL4A2 PRKAG2 COL4A1 SBF1 SBF2 CPD COL3A1 YWHAB PICALM COL7A1 AKT1 RAB3A SYT1 YWHAZ COPB1 ITSN2 CD59 CD55 TFRC ITSN1 HSPA8 FNBP1L FNBP1 TF DYNC1LI1 DYNC1LI2 SURF4 MYO6 KIF3A CTSZ ARPC1A HYOU1 CD3G VAMP3 GPS1 LMAN1 STX5 YKT6 SAA2;SAA1 PRKAA2 MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 HMGB1-1 SEC22A SEC22C NAPB CHMP4C CHMP4B TMED10 STX17 CHMP4A VPS28 LMAN2L USO1 NAPG TSG101 LMAN2 SEC31B ANKRD28 SEC23IP EPGN CNIH1 AP4E1 ARRB1 CRYZL2P-SEC16B;SEC16B CLINT1 CNIH2 AP1G1 FOLR1 CNIH3 FTH1 SYT2 AP1S2 BET1 AP1S1 LDLRAP1 AP1S3 SH3D19 TPD52 VTA1 AP1B1 AP3B1 AP3S2;AP3S1 VAMP8 GAK CHMP2B DNAJC6 NAPA RAB5C CHMP2A TGOLN2 TFG BLOC1S4 BLOC1S6 SPTB SNX2 BLOC1S1 BLOC1S3 RHOBTB3 SNX9 AP1M2 SNX5 TXNDC5 APOE AP1M1 TBC1D8B FTL-1 SNAPIN DVL2 SORT1 HIP1R SEC13 DTNBP1 TPD52L1 PUM1 VPS37C AP4B1 ARPC4 VPS37D IGF2R ARPC5 VPS37A NECAP1 ANK2 VPS37B GOLGB1 COPS4 YIPF6 ACBD3 ARPC2 ARPC3 CHMP3 RAB5B COPS2 SPTBN4 SPTBN5 CHMP6 CHMP7 CHMP5 AVPR2 SNAP23 VPS4B VPS4A MVB12B ACTR2 MVB12A ARFGAP3 COG1 ARFGAP2 WNT5A SPTA1 HIP1 FZD4 UBAP1 CLTB ARRB2 ALB SPARC DAB2 CLTCL1 ZW10 TRIP11 CFTR SCFD1 SPTBN1 STAM CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 SPTAN1 CALR-1 CTTN LNPEP KDELR1 RHOQ GCC2 SEC31A DYNC1I1 STAB2 SH3GL3 SH3GL1 TRIP10 RAB9A RAB9B CD3D DCTN1 HBA2;HBA1 SEC22B STAM2 GNS OCRL PLA2G6 ACTR3-1 GOLGA4 PLIN3 SH3KBP1 STX16 GOSR1 GOLIM4 CYTH3 CYTH2 GOLGA5 AVP ALS2 LDLR CYTH4 STX6 CUX1 VTI1A CYTH1 COG8 COG7 COG6 COG5 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression MYF6 MYCN TCF4 SMAD2;SMAD3 MYF5 TNRC6C MOV10 RXRA TNRC6A-1 AGO4 AGO2 RARA AGO3;AGO1 TNRC6B TCF12 EP300 SMAD4 MYOG HELLS KLF16 TGFBR3 MYOD1 SP1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism ENTPD8 ADAL PNP-1 TXN CTPS2 CTPS1 DGUOK GMPS SAMHD1 GMPR AK4-1 CAD GMPR2 AGXT2 NT5C2 PAICS UPB1 UCKL1 DTYMK AK1 RRM1 AK2 GUK1 ADSS1 TYMS AK5 ADSS2 APRT AK6 TYMP NME2 AK7 NT5C AMPD1 AK8 NME3 AK9 NT5E AMPD2 AMPD3 NME1 CDA NME6 NT5M PUDP NT5C1B;NT5C1B-RDH14 UPP1 UMPS RRM2B XDH DPYS ADPRM DCTPP1 HPRT1 ADSL UCK1 ATIC GDA NME4-1 GLRX TXNRD1 DCTD IMPDH1 IMPDH2 CMPK1 ADA ITPA ADK DPYD NUDT5 PFAS PPAT TK2 TK1 DNPH1 DHODH GART NT5C1A RRM2-1 DCK ENTPD1 ENTPD2 ENTPD3 NUDT16 ENTPD4 NUDT15 ENTPD5 NUDT13 ENTPD6 ENTPD7 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK RELB FBXW11 UBA3 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A MAP3K14 PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres DSCC1 CHTF18 BLM CTC1 STN1 TEN1 ACD TINF2 TERF2 CCNA2-1 POT1 CCNA1 TERF2IP TERF1-1 POLD1 PRIM2 PRIM1 WRAP53 POLA1 POLA2 DNA2 RFC5 RFC3 RFC4 RFC2 DKC1 NHP2 PPP6C TERT PPP6R3 LIG1 RFC1 ANKRD28 NOP10 PCNA WRN PIF1 SHQ1 RPA1 RPA2 CDK2 POLD3 POLD4 POLD2 RPA3 FEN1 RUVBL2 RUVBL1 RTEL1 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation CD22 PTPN6 CD79B CD79A LYN LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer TP53 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane MIB2 PDCD1 DDOST PDCD1LG2 DAD1 TUSC3 CD274 B3GNT3 OST4 MAGT1 JAK1 RPN2 OSTC STT3A RPN1 STT3B TMEM258 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation FGF20 FGF23 TGFBR3 GIPC1 ANOS1-1 FGF6 FGF1 FGF4 FGF9 FGF2 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 GALK1 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SRI CALM3;CALM1 SLC8A1 SLC8A2 SLC24A5 SLC8A3 SLC24A2 SLC24A3 SLC8B1 SLC24A1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis DSCC1 CHTF18 BLM CTC1 STN1 TEN1 ACD TINF2 TERF2 POT1 TERF2IP LIG1 TERF1-1 RFC1 POLD1 PCNA WRN PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 POLD2 RPA3 RFC5 RFC3 RFC4 FEN1 RFC2 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH POLH RPA1 SPRTN RPA2 NPLOC4 UFD1 RPA3 VCP-1 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC RFC1 RCHY1 PCNA UBA52 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion VPS37C VPS37D VPS37A FURIN VPS37B RPS27A PPIA NMT2 UBAP1 UBB;UBC VPS28 TSG101 MVB12B MVB12A UBA52 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN2;FCN1 MASP1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5MJ ATP5MG ATP5ME ATP5PF ATP5PD ATP5MC2 ATP5MC3 ATP5PB ATP5MC1 DMAC2L ATP5PO TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR8 TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 TASL RPS6KA2 IRF5 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SLC15A4 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing NFKB1 GSDMD RELA CTSG NFKB2 IL18 IL1A CASP1 IL1B SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB1 ITGB5 ACTN1 TNC ITGA6 ITGA2 ITGB4 ITGAV TGFB1 FGF2 SDC1 VTN TRAPPC4 ITGB3 CASK SDC4 SDC2 SDC3 THBS1 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 RPGRIP1L CEP43 B9D2 MKS1 FBF1 TTBK2 NPHP1 MARK4 RAB3IP AHI1 YWHAE CEP83 CEP57 CEP89 C2CD3 CETN2 CEP164 CCP110 AKAP9-1 TCTN3 TCTN2 MAPRE1-1 TCTN1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 CC2D2A NEK2 IQCB1 CEP290 YWHAG RAB8A KIF24 CDK5RAP2 HSP90AA1 CEP135 TMEM216 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 TMEM67 HAUS2 TUBA4A HAUS1 SEPTIN2 CEP63 SCLT1 RAB11A PAFAH1B1 DYNC1I2 DCTN2 CEP162 SSNA1 B9D1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B CEP97 NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF PTK2B AKT2 NOS3 AKT3 NRP2 NCK2 VEGFA SHC2 NCK1 MAPK13 ITPR1 ITPR2 ITPR3 CDH5 ROCK2 MAPKAP1 PLCG1 NRP1 WASF2 WASF3 ROCK1 BAIAP2 PRKACA-1 AAMP VEGFB CTNND1 VEGFC VEGFD CTNNB1 RAC1 HSP90AA1 RHOA ELMO1 ELMO2 CRK HSPB1 DOCK1 PTK2 AKT1 PXN PRKCD RICTOR PRKCA MAPKAPK2 BCAR1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 VAV1 VAV2 MAPK14 MAPK11 MAPKAPK3 PRKCB PAK1 ITGAV PRKCZ CTNNA1 PAK3 NCKAP1L JUP CAV1 PRKACB-1 PGF FLT1 THEM4 SHB PRR5 PDPK1 MLST8 CDC42 PIK3R2 PIK3CB CYBB HRAS CYBA PIK3R1 RASA1 FYN NRAS PIK3CA MTOR KDR ABI2 CALM3;CALM1 ABI1 ITGB3 PAK2 NCF1 NCF2 NCF4 TRIB3 AHCYL1 SPHK1 FLT4 MAPK12 AXL INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters SLC4A4 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLC4A7 SLC4A1 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A1 SLC22A3 SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS PTDSS2 PTDSS1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation JUN SOS1 GRAP2 PLCG2 PAK1 RAC1 LCP2 MAP3K1 FOS LYN PAK2 VAV3 SYK PLCG1 VAV1 MAPK1 HRAS VAV2 MAP2K4 MAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 NRAS SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 PIAS4 NUP205 NUP42 UBE2I AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 SUMO1 SUMO2 NUP153 NUP35 TOPORS NUP62 NUP37 NDC1 SEC13 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling FGF20 FRS2 PPP2R1A FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 UBA52 CBL PPP2CB;PPP2CA RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FGF6 MKNK1 FGF4 SPRY2 FGF16 FGF9 FGF18 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins VIM ADD1 DBNL CASP3 GSN CASP7 CASP6 GAS2 MAPT SPTAN1 CASP8 PLEC GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases PPP1R3C GAA RPS27A EPM2A UBB;UBC GBE1 GYG2 GYG1 G6PC1 GYS2 GYS1 G6PC3 SLC37A4 NHLRC1 UBA52 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 GNGT1 GNB5 PRKAR2B GNAT3 IL6 GNAI1 ADORA2B GNAZ GNAI3 PRKX GNAI2 PRKACA-1 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse MYL6 NGEF ROCK2 MYH14 MYH11 YES1 MYH10 RHOA MYL12B FYN ROCK1 MYH9 LYN TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases APAF1 CASP10 ATM TP53 TP63 TP73 PIDD1 NLRC4 CASP6 CASP2 CRADD CASP1 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT4 TCP1 CCT6A CCT3 CCT2 CCT8 ACTB-1 CCT7 CCT6B DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL7C BCL7B SMARCA4 DPF2 SMARCC1 SMARCC2 BCL11A ARID1A ACTB-1 SMARCE1 SMARCD1 SMARCB1 BCL11B SMARCD2 PHF10 SS18 BCL7A SMARCD3 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling NOTCH1 HES1 SNW1 MAMLD1 RBPJ KAT2B KAT2A MAML2 EP300 MAML1 RUNX3 MAML3 CREBBP JAG1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling ATP6V0B MCOLN1 TF ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V1E2 ATP6V1B1 ATP6V1G1 ATP6V1G2 ATP6V1H ATP6V1G3 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 ATP6V0A4 ATP6V0E2;ATP6V0E1 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 ATP6AP1 TFRC STEAP3 STEAP4 HFE TCIRG1 TFR2 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation DLG2 DLG3 DLG4 CAMK2G GRIA2 SRC GRIA1 NRGN GRIN2A NRG1 GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 CAMK2B GRIN2C CAMK2D GRIN2D CAMK2A MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E UBB;UBC RPS27A UBA52 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 GFPT1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events ISCU CHMP3 DDX5 CHMP6 CTSV;CTSL CHMP7 TMPRSS2 MAP1LC3B2;MAP1LC3B-1 CHMP4C CHMP4B GPC1 UVRAG CHMP4A ACE2 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 PIK3R4 GPC4 HSPG2 GPC6 FURIN CHMP2B AGRN VCP-1 CHMP2A SDC1 PIK3C3 NRP1 BECN1 RB1 ZCRB1 VHL METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors NMNAT3 MMADHC BST1 NMNAT2 PDSS2 HPDL PDSS1 NMNAT1 COQ8A APOB NOS3 VKORC1L1 ST20-MTHFS;MTHFS PDZD11 LRAT SDC4 SLC25A51;SLC25A52 RBP4 SDC2 SLC5A8 SDC3 RBP2 THTPA NMRK2 MTHFD1 RBP1 NMRK1 MTHFD2 SHMT2 SHMT1 PARP16 RETSAT PARP14 RDH11 PARP10 CD38 SDC1 VKORC1 PARP6 GCH1 PARP4 CYB5R3 AMN GPIHBP1 PRKG2 PARP9 QPRT PARP8 APOA2 APOA1 MCCC2 APOA4 SLC5A6 HSP90AA1 GSTO2 BTD GSTO1 PC PCCA HLCS MCCC1 PCCB ACACB TTR ACACA BCO2 BCO1 GPC1 FOLR2 GPC3 APOC3 MMACHC GPC2 SLC46A1 GPC5 AKT1 GPC4 APOC2 GPC6 MTR-1 UBIAD1 MTRR NADSYN1 NNMT SLC52A3 PANK4 FLAD1 AGRN PANK3 GPHN PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 ALDH1L1 PPCS ALDH1L2 FASN ENPP2 ENPP1 LMBRD1 SLC25A42 MTHFD2L ENPP3 AASDHPPT NUDT12 LPL AKR1B15;AKR1B10 CTRB1;CTRB2 CD320 NADK CBLIF SLC22A13 NAXE DHFR2;DHFR HSPG2 ACO1 PTS MMUT NT5E NAXD MTHFD1L CUBN SPR NADK2 ACP5 NAMPT PLB1 CLPS SLC25A19 STARD7 TTPA PNPO SLC19A3 PNLIP LRP1 SLC19A1 SLC19A2 MTHFR TCN2 CALM3;CALM1 TCN1 LRP2 LRP8 IDH1 SLC23A2 COQ9 SLC23A1 COQ7 MOCS2 COQ6 MOCS3 COQ5 COQ3 RFK CYB5A COQ2 LDLRAP1 MMAA ABCD4 MMAB SLC52A1;SLC52A2 GCHFR LRP10 LRP12 SLC2A1 SLC25A32 PRSS3;PRSS2;PRSS1 APOM NAPRT AOX1 LDLR APOE TPK1 RNLS ABCC1 MOCOS PDXK NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway AAMP TNFAIP3 UBE2V1 CYLD BIRC2 CHUK BIRC3 CASP8 MAP2K6 IRAK1 IRAK2 IKBKB IKBKG UBE2N TAB3 CASP5;CASP4 MAPK13 TAB2 TAB1 ITCH CASP2 CASP1 TRAF6 MAP3K7 CASP9 CARD9 MAPK14 MAPK11 NOD1 MAPK12 NOD2 RIPK2 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB THEM4 PDPK1 AKT2 TRIB3 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines PSMA6 PSMC5 PSMA3 PSMC6 AGMAT PSMA4 SMS PSMC3 PAOX NQO1 PSMA1 PSMC4 PSMC1 SAT1 SRM PSMD12 PSMD11 PSMD14 AZIN2 PSMD13 PSMA7 ODC1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 OAZ1 PSMD3 PSMB1 PSMD1 AMD1 ADRM1 AZIN1-2 PSMC2-1 PSMA2-1 PSMA5 SEM1 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption TREH GUCA2B CEL GUCA2A LIPF CHIT1 PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B SI LCT PNLIP SLC2A2 ALPG;ALPP;ALPI-1 RSC1A1 CLPS SLC2A5 GUCY2C SLC5A1-1 PNLIPRP1 MGAM G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase CDK2 E2F1 CCNA2-1 CCNA1 E2F3 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins SCP2 PHYH-4 ACOX1 AGPS TYSND1 HSD17B4 ACAA1-1 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly NOTCH1 HDAC6 DLL1 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG RAB8A CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 MYB PAFAH1B1 TNPO1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B KIFAP3 HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 IFT172 TUBB4B CEP97 NEDD1 KIF3B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 KIF3C IFT52 CDK1 IFT57 DYNC2H1 TPTEP2-CSNK1E;CSNK1E IFT140 CEP41 CEP43 RPGRIP1L WDR35 IFT88 SMO KIF3A TTC21B WDR19 IFT122 MKS1 GRHL1 CCT3 CCT2 E2F5 TCP1 CCT8 CCT5 CCT4 ARF4-1 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 E2F4-1 NPHP1 NPHP3 MARK4 RAB11FIP3 ARL13B BBS2 BBS1 TFDP1 RAB3IP BBIP1 AHI1 CEP83 CEP89 C2CD3 GMNN PKD2 PKD1 DYNC2I2 TCTN3 DYNC2I1 TCTN2 TCTN1 TTC26 TRAF3IP1 BBS9 DYNLT2B CNGA2 KIF17 BBS7 HSPB11 CNGA4 DYNC2LI1 BBS5 CC2D2A IFT74 TP73 BBS4 DYNLT5 IQCB1 DYNLT2 IFT80 MKKS EXOC8 IFT20 EXOC7 IFT22 KIF24 IFT43 IFT81 SSTR3 BBS10 TTC30A;TTC30B BBS12 TRIP11 IFT27 RP2 DYNLRB2 TMEM216 EXOC4 DYNLRB1 EXOC3 IFT46 EXOC6 CLUAP1 EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 TMEM67 PDE6D RHO SEPTIN2 GBF1 SCLT1 RAB11A ATAT1 TTC8 CEP162 B9D1 MCIDAS RFX2 RFX3 CCNO GRHL3 GRHL2 INPP5E DEUP1 GMNC FOXJ1 B9D2 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events OPN1MW3;OPN1MW2;OPN1MW;OPN1LW TTR NAPEPLD LRAT RDH5 STRA6 RDH12 OPN1SW RBP4 RLBP1 ABCA4 RBP1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin TTLL11 TUBA1A TTLL9 TUBA3E;TUBA3C-1 TUBA1C TUBB1 TPGS1 TTL TPGS2 SVBP ARPC4-TTLL3;TTLL3 TTLL12-1 TUBB2B;TUBB2A AGTPBP1 LRRC49 NICN1 VASH2 VASH1 AGBL5 TTLL7 AGBL4 TTLL6 TTLL5 TUBB4B TTLL4 AGBL1 AGBL3 TUBB4A;TUBB;TUBB8B;TUBB8 TTLL1 AGBL2 TUBB3;TUBB6 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease FGF20 CPSF6 FRS2 GAB1 BCR SOS1 FGF23 PIK3CA CEP43 STAT3 FGFR1 TRIM24 GAB2 FGF2 BAG4 ERLIN2 STAT1 MYO18A LRRFIP1 FGFR1OP2 STAT5A STAT5B ZMYM2 PLCG1 HRAS PIK3R1 CUX1 FGF1 FGF6 FGF4 NRAS FGF9 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis HSD3B1;HSD3B2 CYP17A1 CYP21A2 HSD11B1 CYP11B1;CYP11B2 HSD11B2 SERPINA6 POMC DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP1BA GP5 GP9 GGCX F8 F9 F10 GP1BB F11 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 FGF20 FGF23 FGF22 FGF3 FGF10 PLCG1 FGF6 FGF1 FGF4 FGF9 FGF2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN EDIL3 CDH2 SERPINE1 CDH1 SOX2 ZEB1 ITGA2 STT3B GXYLT2 PXN MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events ADD3 MRS2 SLC66A1 ADD2 NIPAL4 PIP-1 ANKH NIPAL1 NIPAL2 NIPAL3 LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E RHAG DMTN MMGT1 NIPA1 CTNS NIPA2 AZGP1 RHCG RHBG TUSC3 ADD1 MAGT1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs ACSBG2 TECR ACSF3 SLC27A3 HACD1 ACSL1 HSD17B3 ACSL6 ACSL5 ELOVL1 TECRL HACD3 ELOVL4 HSD17B12 HACD2 ELOVL2 HACD4 ELOVL3 ELOVL6 ELOVL7 ACSL4 ACSBG1 ELOVL5 ACSL3 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs RAB6A RAB33B-1 TBC1D25 RAB11B ULK1 GABARAP TBC1D13 RAB8A TBC1D14 RAB5B TBC1D17 RAB6B OPTN-1 TBC1D15 TBC1D16 MAP1LC3B2;MAP1LC3B-1 RAB7A RAB11A TSC2 TSC1 RAB8B RAB4A RABGEF1 RAB33A RAB5C TBC1D10C TBC1D2 RABEP1 RAB7B TBC1D10A ARF6 TBC1D10B RAB5A RABGAP1 GABARAPL2 SYTL1 GGA2 GGA1 GGA3 TBC1D20 TBC1D7;TBC1D7-LOC100130357 RAB35 TBC1D24 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus MIB2 DLL1 JAG2 WWP2 PSEN1 DLL4 RPS27A PSENEN NCSTN NEURL1 TACC3 PSEN2 UBB;UBC EGF NEURL1B APH1A EGFR APH1B MIB1 NOTCH3 YBX1 JAG1 UBA52 ADAM10 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism NUDT7 HACL1 ACOT4 AMACR ACOXL SLC27A2 PHYH-4 PECR EHHADH-1 HSD17B4 ABCD1 ACOX2 ACOT8 ACOX3 CRAT CROT NUDT19 DECR2 ACBD5-1 SLC25A17 ACBD4 ACAA1-1 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation AMT DLD OGDH GLDC MRPS36 DLST GCSH-3 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly SMIM20 TMEM223 COA5 TACO1 COX6A1 COX6A2 COQ10A-1 SURF1 COX7B COX7A2 COX7C COX6B2 COX6B1 SCO1 COX8A SCO2 COX19 COX8C RAB5IF COX15 TIMM21 COA3 COQ10B COX18 PET117 NDUFA4 COX17 TMEM177 CMC1 COX4I1 COX4I2 HIGD1A COX5B COX5A COX11 COX14 HIGD2A COX7A2L-1 COX20 COX6C DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression HERPUD1 CXCL8 DDIT3 EIF2S2 HSPA5 EIF2S3;EIF2S3B CCL13;CCL2 EIF2AK3 EIF2S1 ATF6 KHSRP DIS3 CEBPB ATF4 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 IGFBP1 ATF3 EXOSC9 EXOSC8 DCP2-1 ASNS EXOSC3 EXOSC2 EXOSC1 NFYA-1 CEBPG NFYB NFYC RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 CDC37 ERBB2 ERBIN HSP90AA1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NOP58 BMI1 NUP93 NUP205 NUP42 UBE2I RING1 HNRNPC AAAS PCGF2 NUP160 NUP43 NUP85 RNF2 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 CBX8 SUMO1 SUMO2 NUP153 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 NUP62 HNRNPK NUP37 NDC1 SEC13 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs TNRC6A-1 AGO2 AGO3;AGO1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H POLR2L IPO8 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C H2BC15;H2BC3;H2BC11;H2BC12 POLR2D H2BC5 H2BC21 POLR2G H2BC1 POLR2I H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 POLR2J;POLR2J2;POLR2J3 H2AC4 RAN H2AC14 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism HYKK DLD PIPOX GCDH AADAT ALDH7A1 DLST CRYM PHYKPL SLC25A21 AASS DHTKD1 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex TRAF6 UBB;UBC MAP3K7 TLR3 TICAM1 TAB3 TAB2 RPS27A UBA52 TAB1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation HMGB1-1 H1-0 CASP3 H1-3 KPNB1 H1-2 H1-5 DFFB H1-4 DFFA HMGB2 KPNA1 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction PDPN CXCR4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 H2AB2;H2AB3;H2AB1 C1orf112 B4GALT1 BRCA2 FIGNL1 ATM TET2 ATR BRCA1 H2AJ FKBP6 POU5F1;POU5F1B TOP3A H2BC5 H2BC1 RPA1 RPA2 CDK4 MLH1 CDK2 RPA3 H2AC4 MRE11 NBN EOMES NANOG;NANOGP8 SOX17 BLM ACD TINF2 SPO11 SYCP1 SYNE2 TERF2 SYNE1 POT1 SUN1 TERF2IP TEX12 TERF1-1 SMC1B MSH4 MSH5 DMC1 SYCP3-2 PSMC3IP RAD51 SYCE2 SYCE1 UBE2I MND1 HSPA2 MLH3 REC8 STAG3 SYCP2-1 H2BC21 RAD51C CATSPER1 KCNU1 BMP4 CATSPER3 CATSPERB CATSPER2 H2AZ2;H2AZ1 CATSPERD CATSPER4 CATSPERG PRDM1 SMC3 SPAM1 RAD21 RBBP8 STAG1 HVCN1 STAG2 SMC1A RAD50 PRDM7;PRDM9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LMNB1 NANOS3 H2BC15;H2BC3;H2BC11;H2BC12 ADAM2 ZP3;POMZP3 TFAP2C ACR IZUMO1-1 OVGP1 IZUMO3 IZUMO2 IZUMO4 CBFA2T2 ZP1 ZP2 SUN2 ZP4 ADAM21 ADAM20 ADAM30 CD9 H2AC14 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling CDK5R1 SEMA3A CRMP1 PLXNA2 PLXNA3 CDK5 FES GSK3B NRP1 FYN PLXNA4 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNA1 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine GLYATL3 ACSM5 ACSM4 ACSM2A;ACSM2B GLYAT ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG DGAT2 PNPLA2 DGAT1 AWAT2 DGAT2L6 MGLL PNPLA3 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) CP SLC40A1 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding GNG10 GNG2 GNG5 GNG4 GNG8 CALM3;CALM1 GNG13 GNB2 GNB1 GNB4 GNB3 GNGT1 DLG3 DLG4 GNB5 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 PLCB3 PLCB1 PLCB2 DLG1 NCALD DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling UBB;UBC ITCH NEDD4 SRC WWP1 RPS27A UBA52 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction OPN1MW3;OPN1MW2;OPN1MW;OPN1LW TTR NAPEPLD LRAT RDH5 STRA6 RDH12 OPN1SW RBP4 RLBP1 ABCA4 RBP1 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins OPN1MW3;OPN1MW2;OPN1MW;OPN1LW OPN3 RGR RRH OPN5 OPN1SW RHO OPN4 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle CDK1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AURKB PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CDC14A ANAPC15 ANAPC16 CUL1 UBE2D1 AURKA ANAPC10 CCNB1 ANAPC11 CDK2 PTTG1;PTTG2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 PLK1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib CDC37 ERBB2 ERBIN HSP90AA1 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein BAK1 BID IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex TRAF6 UBB;UBC MAP3K7 TAB3 TAB2 RPS27A UBA52 IRAK2 TAB1 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity A2M C1QBP KLKB1 PLAUR SERPING1 KNG1 HRG KRT1 F12 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors TP63 PPP1R13B TP73 POU4F1 PPP1R13L AKT2 POU4F2 AKT3 PHF20 ZNF385A TP53 TP53BP2 BANP AKT1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK ARHGEF7 SOS1 GNA13 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF ABR RASGRF2 PLEKHG2 ARHGEF33 ARHGEF37 ARHGEF38 SOS2 ARHGEF40 FGD1 NGFR FGD2 FGD3 FGD4 ARHGEF26 PLEKHG5 MCF2 RAC1 ECT2 ARHGEF39 KALRN NET1 NGF TIAM1 ARHGEF10L AKAP13 MCF2L ARHGEF11 AATF ARHGEF10 ARHGEF12 MAGED1 VAV3 ARHGEF15 ARHGEF17 TRIO ARHGEF16 ARHGEF19 ARHGEF18 ITSN1 VAV1 VAV2 TIAM2 PREX1 ARHGEF3 ARHGEF4 MAPK8 ARHGEF1 ARHGEF2 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking GJA1 GJC1 GJB2 GJC2 GJB1 GJA3 MYO6 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 CLTC GJB3 CLTA GJB6 GJB5 GJB7 DNM1 DNM2 CLTB DAB2 CLTCL1 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER RBX1 POLK POLE RFC1 PARP2 POLD1 DDB2 ERCC3 PCNA CHD1L UBA52 PARP1 ERCC5;BIVM-ERCC5 ERCC2 GTF2H1 DDB1 GTF2H3 GTF2H4 RPA1 XPA RPA2 POLD3 POLD4 POLD2 RPA3 RPS27A RFC5 RFC3 RFC4 POLE4 CUL4A UBB;UBC RFC2 ERCC4 POLE2 ERCC1 POLE3 GTF2H2C;GTF2H2C_2;GTF2H2 CUL4B CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints BUB1 CLASP2 BUB1B CDC20 CCNA2-1 CCNA1 PPP1CC BUB3 MAD2L1 PSMD12 PSMD11 SFN PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE ADRM1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 YWHAG PSMC1 SKP1 FBXW11 YWHAB CKAP5 XPO1 UBA52 PAFAH1B1 DYNC1I2 CUL1 YWHAZ CCNB2 CCNB1 RPS27A CLASP1 UBB;UBC MCM10 DBF4 DYNC1H1 MAPK14 MAPK11 NDE1 PLK1 CDK1 TPTEP2-CSNK1E;CSNK1E DYNC1LI1 DYNC1LI2 KIF18A RBX1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 GTSE1 UBE2N CSNK1A1 NUF2 KIF2A YWHAQ NUDC YWHAH KIF2C KIF2B INCENP CENPA CENPE CENPC WEE1 TP53BP1 CENPT NUP107 CENPU CENPF RNF168-1 CENPH CENPI TAOK1 CENPK CENPL CENPM NEK11 CENPO CENPP NUP160 NUP85 CENPQ CLIP1 MAD1L1 BRIP1 CCNE2 CCNE1 SEC13 NUP133 NDC80 RANGAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SPDL1 MDC1 NUP43 KAT5 CHEK2 CHEK1 RANBP2 HUS1 DNA2 RHNO1 PHF20 NSL1 PCBP4 ATRIP NUP37 BARD1 PLK3 ORC5 COP1 ORC4 ORC6 CDC7 ORC1 ORC3 RAD17 ORC2 ATM CDC6 ATR CDKN1A CDKN1B KNL1 ZW10 BRCA1 BABAM1 DSN1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 RCC2 ZWINT H2BC5 WRN AHCTF1 H2BC1 RPA1 HERC2 RPA2 CDK2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A RPA3 PPP2R5D PPP2R5C RAD1 PPP2R1B PPP2R5E CLSPN MRE11 NBN CDC25C BLM MDM2-2 DYNC1I1 GSK3B PIAS4 B9D2 MDM4 RAD9B H2BC21 SPC24 SPC25 RAD9A ERCC6L PKMYT1 ZWILCH EXO1 PMF1;PMF1-BGLAP TOPBP1 ZNF385A RFC5 RFC3 RFC4 TP53 RFC2 KNTC1 BIRC5 SGO1 UBE2V2 SGO2 AURKB CENPS-CORT;CORT;CENPS RBBP8 RAD50 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CDC45 ANAPC11 MCM7 NSD2 MCM8 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 CDKN2A MCM6 UBE2C MCM2 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 PROC F5 PROS1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription RRN3 CDK7 MNAT1 CAVIN1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 H2BC21 UBTF H2AC20 PHF6 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 HDAC2 HDAC1 TAF1D MTA1 TAF1B RBBP4 TAF1C KAT2B H2AJ KAT2A TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 MBD2 H2BC1 ERCC2 GTF2H1 GTF2H3 ERCC6 GTF2H4 GATAD2B GATAD2A TTF1 H2AC4 MAPK3 CCNH EHMT2 H2AC14 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors ADRA1A ADRB1 ADRB2 ADRA2C ADRB3 ADRA2A ADRA2B ADRA1D ADRA1B FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer NOTCH1 CUL1 RBX1 SKP1 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway CAMK2G ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG PRKCD NBEA PRKCA CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 KPNA2 PRKX CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion HGS UBB;UBC CORO1A RAB7A RAB5A VPS33B RPS27A UBA52 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic KDELR1 KIF18A KIF18B SURF4 KIF12 KIF11 KIF15 KIF19 KIF13B KIF1C KIF1B KIF1A KIF3A KIF25 KIF23 KIF22 ARFGAP3 KIF6 KIF27 ARFGAP2 KIF9 ARF4-1 KIF2A KIFC2 KIFC1 KIF2C KIF2B NSF TMED2-1 RAB1A SEC22B RAB1B CENPE KIF26A KIF26B RINT1 KDELR2 ARF1 COPB2 COPA ZW10 COPE USE1 TMED3 TMED7 TMED9 COPZ2 COPZ1 NAPB ARF5 TMED10 NBAS STX18 NAPG GBF1 BNIP1 ARCN1 COPG2 COPG1 KIF5B KIF5A COPB1 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B NAPA ARFGAP1 KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KDELR3 KIF3C DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology MARK3 CLASP2 LIMK2 LIMK1 CSNK2A1;CSNK2A3 RPL10A HDAC11 BMI1 ETS1 TNF RARS1 YY1 IL4R EBF1 KLF13 RING1 IL13 MAF IRF4 CCL3L1;CCL3L3;CCL3;CCL18 HDAC5 SATB1 HDAC9 RNF2 HDAC6 CNTN1 HDAC7 TBX21 STAT6 CBX8 STAT5A STAT5B CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 NFATC2 NFATC1 POU2F2 PHC3 BATF IL4 EGF IL5 ERBB2 PLCG1 EGFR RPL36AL-1 YWHAE PRKACA-1 YWHAG HSP90AA1 TCF7 TERT CYP51A1 AJUBA UBA52 CSF1 CCNB1 ST8SIA2 RPL18A RPS27A RPS6KA3 RPS6KA5 CLASP1 UBB;UBC RPS6KA2 RPS6KA1 MEF2A MEF2C PLK1 SPI1 HELZ2 STAT3 BCL2 TYR CAPNS1 GRIN2B CDH1 INS;INS-IGF2 HEY1 HEY2 CAPN1 ADAM10 PSEN1 NCSTN COL9A1 COL9A3 COL9A2 LAMC2 LAMC1 RPL15-1 FOXO4 FOXO3 MMP2 MMP9 LAMA5 LAMA3 FURIN HAND2 ITGA5 YAP1-1 LAMB3 LAMB1 TBX5 SMARCB1 DCT THRAP3 TRIM33 H2AC14 DPF1 DPF2 DPF3 FAM120B TGFA MED1 SMARCC1 SMARCC2 WWTR1 YES1 MED4 MED6 MED7 HNF4G PAXIP1 FOXO1-1 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PPARGC1B CREBBP RAB27A IHH CCND3 SS18L1 SMARCA2 SMAD2;SMAD3 SMARCA4 H2AC20 LDB1 H2AB2;H2AB3;H2AB1 EZH2 RPL10;RPL10L-1 ASH2L MED16 MED17 SERPINE1 MED12 MED14 MED13 MED10 SOX1 CD36 ZIC2 OTX2 NCOA1 POU3F1 NKX2-5 NCOA2 SS18 NCOA6 NCOA3 ACTL6A RARG MED27 SIRT1 MED23 TEAD1 RPLP0 TEAD2 NCOR2 KAT2B H2AJ TEAD4 KAT2A TCF12 NCOR1 RPLP2 MED24 TAL1 RPL36-1 RARB TET3 WNT10B MED20 ANGPTL4 ELOVL3 MC4R PLIN1 HINT1 EDNRB MBD3 TNFSF11 FOXD3 SUZ12 H2BC5 EDN1 PCGF2 EDN3 TFE3 H2BC1 MITF SOX10 POU3F2 MC3R TFEC GATAD2B ALX3 ITGA2B GATAD2A TBX3 FABP4 MC1R KARS1 MC5R UCP1 ID1 MED31-1 EP300 MEN1 H2AC4 ADIPOQ TBL1XR1 KMT2D PLXNA4 KMT2A KMT2C LPL MED30 ABL1 RPL22L1 ZNF521 CDK8 CDK5 ACTB-1 RPL37A-1 GSK3B KLF4 DPY30 CHD4 SOX9 CHD3 PAGR1 BCL7A SIN3A H2BC21 BCL7C BCL7B WDR5 KDM6A EED H2AZ2;H2AZ1 ARID1A ARID1B SMAD1 SMAD4 PIK3CD SMARCD1 CEBPA SMARCD2 HDAC2 RPL13A-1 SMARCD3 HDAC3 UHRF1 HDAC1 HES1 MTA1 RBBP4 RBBP5 TFEB H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L SMARCE1 ITGB3 DEK H2BC15;H2BC3;H2BC11;H2BC12 IARS1 DMRT1 SRY ADIRF SLC2A4 ZNF638 ZNF467 KLF5 RPL23A GPR143 SEMA5A STX1A PIK3R3 RPL27A MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 WASL LEF1 RBPJ DLL1 PSMA7 DLL3 PSMD8 LFNG PSMB6 PSMB7 PSMD6 LEP PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 CDON PSMD2 PSMD3 ANK3 PSMB1 PSMD1 HES7 EPHA4 ADRM1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 RIPPLY2 PSMC3 PSMA1 ATP6V1G1 PSMC4 PSMC1 CTNNB1 ATP6V0D1 YWHAB ATP6V1A XPO1 KRT1 AKT1 PRKCA YWHAZ ATP6V1C1 CHD9 HSPA8 PABPC1;PABPC3 MAPK14 DARS1 MAPK11 ZEB2 ZEB1 EIF4G1 ATP6V0B MEF2D ATP6V1B2 ATP6V0C RBX1 TREM2 TYROBP NUMB RPL26L1 RPL4 RPL30 RPL3 RPL32 PRKACB-1 RPL31 RPL34 PRKAR2A RPL8 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 MYRIP RPL35 RPL38 DAG1 RPL39 RPL21 RPL23 RPL22 HRAS MED8 FYN MED9 RASA1 CSF3R RPL24 NRAS RPL27 RPL26 RPL29 RPL28 CDK19 LIG1 RPL3L RPLP1-2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D ITGA1 SEMA7A SEMA3A CRMP1 SEMA3E RRAS PLXNA2 PLXNA3 POLR2J;POLR2J2;POLR2J3 SEMA4A CD72 SEMA4D PTPRC FES PLXNB3 NTN3 CDH4 CDH2 BNIP2 ASAH1 ELOC-1 CTNNA2 NEO1 RPL11 RPL14 SPAG9 MEF2B;BORCS8-MEF2B MAPK12 ELOB RPL13 RPL18 CDH15 RPL17 CACNB1 RPL19 CACNB4 NCBP1 CXCR4 POLR2A IRS2 CACNB2 POLR2B PRL CACNB3 POLR2C POLR2D POLR2G POLR2I WNT1 NCBP2-1 CLTB PPP3CB CLTCL1 RPL7A NCAN TYRP1 RPL35A LGI1 LGI4 LGI3 LGI2 ADAM11 ADAM22 CACNG8 ADAM23 CACNG2 CLTC CACNG3 CLTA CACNG4 AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 PTGDS FOXF1 SIAH2 SIAH1 ITGB1 ROBO2 RET FOXC2 FOXC1 SIX1 GATA3 PCDH19 HOXD11 FGF2 HOXC11 WFDC2 HOXA11 PLAC8 SALL1 WNT11 MECOM CIDEA SIX2 HNF4A SLIT2 HOXA6 WNT4 IRX1 IRX2 EMX2 JAG1 CTCF QARS1 EYA1 OSR1 WNT9B GFRA1 HNF1B NPNT PAX2 POU3F3 GREM1 BMP4 PAX8 VASP GDNF WT1 ENAH LHX1 ID4 ITGA8 HOXB4 PIK3R2 PIK3CB PIK3R1 MYC CUL2 AKAP5 FRS2 PIK3CA TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 SCD5 AGO3;AGO1 RANBP9 TNRC6B TGFB1 CCND1 EZR CBFB RUNX3 RUNX1 HOXA3 HOXA1 PKNOX1 HOXA4 PIAS2 TFAP2A HOXB3 HOXB2 TFAP2C HOXB1 HOXD1 MEIS1 TFAP2E;TFAP2B MAFB RDX HOXD4 HOXD3 ZNF335 CEBPB BIRC7 RELA NAB1 NAB2 TCF7L2 SLC2A2 CDKN2A EGR2 NFKB1 RPS15 HOXC4 RPS14 RPS17 SPTBN2 RPS16 MARS1 RPS19 RPS18 AKT2 AKT3 RPS11 RPS10 RPS13 RPS12 SDC2 POMC CDC25B SRPK1 PRDM14 RPS25 RPS27 LIN28A ZIC3 RPS29 ZSCAN10 RPS20 TDGF1 RPS21 RPS24 DLG1 RPS23 NRP1 GAB1 MET AREG MYO10 MYO5A CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GXYLT2 SPRR3 SYTL2 FGF7 CSTA KLK5 PMEL EDIL3 PCSK6 EVPL MLANA RPS27L TBX2 KLK8 FGF10 PPL MLPH LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 RPS15A TCF7L1 GPC1 TGM1 WNT3A CASP14 DLX5 LIPJ POU5F1;POU5F1B RPS3 PAX3 SPRR1A;SPRR1B LIPN SOX2 LIPM PAX7 ZIC1 PRSS8 LIPK MYB NELL2 MSX1 TGM5 SLIT3 ST14 RPS2 CDSN SPINK6 SPINK5 KLK13 KLK14 KAZN CELA2B;CELA2A LCE6A PKP2 PKP1 LORICRIN DSG3 KIF4B;KIF4A FAU AGRN PKP3 SPINK9 FGF8 DSG4 DSC1 ZFPM2 IVL GATA6 DSC2 DSC3 GATA4 RPS9 GATA2 RPS7 RPS8 RPS5 RPS6 RPSA CNTN6 CHL1 ITGA2 ITGA10 ANK1 UNC5A DCC UNC5B UNC5C UNC5D NTN1 STT3B HSP90AB1 RPS4X YWHAH RPS3A CDC42 ST8SIA4 EIF4A2 BTG4 EIF4A1 TUT7 TUT4 DUXB DIS3L2 STPG4 DICER1 PTPN11 METTL23 DPPA4 DPPA3 DPPA2 ZFP36L2 LEUTX HIRA DUX4;DUXA EIF4E EIF4B PAIP1 NPM2 AICDA H1-8 TPRX1;RAX2 ATP6V1H ZSCAN4 PABPN1-1 PITPNA RPS6KA6 CFL1 STAT4 PAK2 IL12RB2 DLG3 MSN IFNG CACNA1H GRIN1 ONECUT1 NEUROD1 NKX6-1 NKX2-2 MYH9 PDX1 PAX6 HNF1A MAFA RFX6 HIF3A IAPP INSM1 KAT5 PTF1A FOXA3 NEUROG3 FOXA2 MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 E2F1 JUN SNW1 MAMLD1 MAPK7 CDKN1A LEFTY2;LEFTY1 ARHGAP35 BRCA1 RAC1 RHOA TNKS1BP1 DOK1 CNOT6L FOS DOCK1 CFC1;CFC1B DAND5 NODAL EPAS1 PXN PERP CDK4 CDK2 CER1 FOXH1 PSEN2 APH1A APH1B DRAP1 SOX17 MYF6 TCF4 MYF5 FLRT3 EIF4A3 CASC3 PBX1 ITGAV MAP2K6 AMH CNOT10 PSENEN MYOG CNOT4 CNOT6 NOG MAG CNOT7 MYOD1 CNOT11 CNOT1 ACVR1B CNOT2 CNOT3 ACVR1C RBM8A ACVR2B ACVR2A CNOT8 CNOT9 MAGOH;MAGOHB UPF3B RNPS1 TRPM1 NR2F2 TRPC7 TRPC5 TRPC6 FOXA1 TRPC3 TRPC4 TRPC1 CXCL12 HDAC10 USF1 DOK2 SHC1-1 PRDM16 PRKCQ LYN TIAM1 CDK5R1 GCK KRTAP27-1 KRTAP16-1 KRT81;KRT83-1 MCM5 FLI1 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 MCM2 KRTAP4-3 MBP MAP2K2;MAP2K1 KRTAP13-4;KRTAP23-1;KRTAP13-3-1 ZNF423 ADGRV1 KRT3;KRT76 MAPK1 KRTAP29-1 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 MAPK3 KRTAP8-1 KRTAP9-4;KRTAP9-3;KRTAP9-8;KRTAP9-7;KRTAP9-6;KRTAP9-2;KRTAP9-9-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 MPZ FGF4 ADGRG6 HMGCR FGF9 KRTAP10-8 KRT16;KRT14 KRT6B;KRT6C;KRT6A SOS1 KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRTAP26-1 GRB10 KRTAP3-1 KRT10-2 KRTAP3-2;KRTAP3-3-1 KRTAP19-5 MSI1 CEBPE HOXA2 GFI1 ISL1 KRT4 KRT2 COL4A5 GSPT2 KRT8 GSPT1 EBF2 LHX3 KRT7 LHX2 KRT5 LHX4 KRT9 LHX9 KRTAP13-1;KRTAP13-2 GDF1 KDM5A USP33 KRT24 ROBO1 KDM5B UPF2 KRT23 ETF1 KRT20 ZSWIM8 KRT33A;KRT33B;KRT31-2 KDM6B SLIT1 KRT28 KRT27 KRT26 PRX KRT25 KRT32 HDAC8 KRT39 KRT36 KRT13 KRT12 KRT19 KRT18 LARS1 KRT17 KRT15 KRTAP24-1 KRT71 KRT79 KRT78 KRT77 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP11-1 KRT82 KRT80 PIP5K1C KRT85 KRT84 NOTO PMP22 ROCK1 MED19 COL4A2 COL4A1 MED15 COL4A4 MED18 COL6A2 PXDN MED11 COL4A3 COL6A1 DSP COL6A3 COL6A6 COL6A5 MED26 MED29 MED22 MED25 DSG1 MED21 PKP4 EPHA2 KIT MESP1 TBX20 SMYD1 TBX1 MYOCD HAND1 RPL12-1 TRIO ITSN1 EOMES TBXT NANOG;NANOGP8 GSC TBPL2 MIXL1 TPST2 MYL6 NGEF SNAI1 SNAI2 GMPR GAB2 SALL4 JUP SDCBP ARPC1B ARPC1A FN1 SHH CACNA1G CACNA1I NRTN NCAM1 CACNA1S PRNP PSPN GFRA2 GFRA4 ARTN CNTN2 FARP2 IL6R PLXND1 ALCAM SCN11A SCN10A AGAP2 L1CAM LYPLA2 DSCAML1 SHC3 HNRNPU RAP1GAP DAB1 PTPRA CNTNAP1 SPTB ITGA9 NTN4 ABLIM1 ABLIM2 ABLIM3 NFASC EPHB6 PCK1 RPS6KA4 EPHB2 EPHB1 EPHB4 SCN1B EPHB3 PLXNA1 SCN1A ABL2 EPHA5 SRGAP3 EPHA7 MED13L SRGAP2 EPHA6 SRGAP1 ARPC4 EPHA8 AIMP1 ARPC5 ANK2 SHTN1 KCNQ2 KCNQ3 AIMP2 ARPC2 EPHA1 ARPC3 EPHA3 EPRS1 SPTBN4 SPTBN5 EPHA10 PLXNB1 MYL12A SCN3B SCN3A CD24 SCN2A SCN2B NRP2 CEBPD VLDLR CAP1 NCK2 GFRA3 RGMB NCK1 RGMA RELN CAP2 ACTR2 SCN9A NRCAM DSCAM DOK4 DOK5 SCN8A DOK6 EFNA5 DSG2 EFNA4 SREBF2 SPTA1 EVL TLN1 EFNB2 PFN2-1 EEF1E1 EFNB1 SOS2 EFNB3 ROCK2 EFNA1 SRC EFNA3 SRF EFNA2 HJV SCN5A GAP43 DCX SCN4A SCN4B SHANK3 LAMA1 SCN7A PDLIM7 DRP2 FGFR1 PFN1 GRB7 UTRN KALRN MYL12B BMP7 SPTBN1 DHH LAMC3 PTK2 LAMA2 SPTAN1 LAMA4 GIT1 CACNA1D LAMB2 VAV3 CACNA1C RHOC VAV2 RHOB ARHGEF7 PAK1 CTNNA1 PAK3 PAK5 PAK4 HDAC4 MYO9B UBE2I TGS1 NR5A1 RXRA SUMO1 BUB1B-PAK6;PAK6 RARA BCL2A1 CARM1 ARHGAP39 PPARG PPARA ACTG1 TP53 ARHGEF28 CSNK2A2 MYH14 MYH11 MYH10 CSNK2B RPL5-1 VTN DIAPH1 DLG4 ACTR3-1 RND1 ARHGEF11 ARHGEF12 SH3KBP1 MED28-1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT1 PIK3CA LCK STAT5A STAT3 PIK3R3 STAT5B YES1 PIK3R2 HRAS PIK3R1 FYN JAK2 LYN KIT NRAS FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation FGF20 FGF23 FGF6 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis MED13L FAM120B MED1 EBF2 MED4 MED6 MED7 TNF CEBPD EBF1 CCNC-1 PPARGC1A PPARGC1B CREBBP CCND3 SREBF2 WNT1 LEP MED16 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 MED19 NCOA6 MED15 NCOA3 MED18 MED11 MED27 MED23 NCOR2 NCOR1 MED26 MED24 MED29 WNT10B MED22 MED20 MED25 ANGPTL4 BMP7 ELOVL3 PLIN1 MED21 MBD3 GATAD2B GATAD2A FABP4 CDK4 UCP1 MED31-1 CHD9 EP300 ADIPOQ TBL1XR1 LPL MED30 HELZ2 CDK8 KLF4 CIDEA CHD4 CHD3 TGS1 RXRA CARM1 PPARG PPARA SMAD1 SMAD4 NR2F2 MED8 MED9 CEBPA HDAC2 SMARCD3 HDAC3 HDAC1 MTA1 RBBP4 TGFB1 CDK19 RBBP7 PRDM16 MTA2 MTA3 CEBPB ADIRF SLC2A4 ZNF638 RELA ZNF467 KLF5 HNRNPU MED28-1 EGR2 NFKB1 ZNF423 PCK1 THRAP3 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport PLA2G4A RAB6B AGPAT3 CAPZA3 ACTR10 ARFGAP3 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 NSF TMED2-1 RAB1A RAB1B RAB6A ACTR1A RAB18 RAB3GAP2 ARF1 RAB3GAP1 ZW10 GBF1 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 KIF5B KIF5A COPB1 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 KDELR1 DYNC1LI2 KIF18A KIF18B SURF4 KIF12 KIF11 DYNC1I1 KIF15 KIF19 CAPZB KIF13B KIF1C KIF1B KIF3A KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 KIFC1 KIF2C KIF2B DCTN1 SEC22B CENPE KIF26A CAPZA1 KIF26B CAPZA2 BICD1 BICD2 GALNT2 PAFAH1B3 GALNT1 PAFAH1B2 RINT1 KDELR2 COPB2 COPA COPE USE1 TMED3 TMED7 TMED9 COPZ2 COPZ1 NAPB TMED10 ARF5 NBAS STX18 NAPG PLA2G6 BNIP1 ARCN1 COPG2 COPG1 NAPA ARFGAP1 KDELR3 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis HSD17B11 AKR1B15;AKR1B10 HSD17B1 HSD17B2 CYP19A1 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis PDE11A PLA2G4A PDE10A KCNMB1 KCNMB2 KCNMA1 KCNMB3 GNG10 KCNMB4 NOS1 GNAS-1 PDE9A GNG2 GNG5 APOB NOS3 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 P2RX7 P2RX4 FGR TRPC7 PECAM1 PAFAH2 TRPC6 TRPC3 PRKG2 PPP2R1A PTPN11 PTPN6 PTGIR SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 NOS2 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 LRP8 P2RX6 GNGT1 P2RX5 P2RX3 STIM1 P2RX2 P2RX1 ORAI2 ORAI1 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E MAPK14 GUCY1A2 PDE5A GUCY1A1 GUCY1B1 PDE1B PDE1A PDE2A IRAG1 DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion PLCB1 PLCB2 PRKCA GNA14 MARCKS GNA15 GNAQ GNA11 PLCB3 CHRM3 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression DPF1 DPF2 DPF3 AKT2 SMARCC1 SMARCC2 PPARGC1A RAB27A IRF4 SS18L1 SMARCA2 CDC25B SMARCA4 LEF1 SERPINE1 SS18 ACTL6A PXDN MET ATP6V1E1 CDKN1A SIRT1 ATP6V1G1 CTNNB1 BRCA1 TYRP1 TCF7 MYO5A CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GXYLT2 TERT SYTL2 PMEL EDIL3 MLANA TBX2 MLPH TCF7L1 ATP6V0D1 ATP6V1A HINT1 SOX2 PXN SOX10 POU3F2 ATP6V1C1 CCNB1 CDK2 MAPK14 PLK1 ZEB1 ATP6V0B ATP6V1B2 ATP6V0C BCL2 GMPR ITGA2 TYR ACTB-1 CDH1 BCL7A STT3B SIN3A BCL7C BCL7B ATP6V0E2;ATP6V0E1 MYRIP BCL2A1 ARID1A TRPM1 ARID1B SMARCD1 SMARCD2 SMARCD3 HDAC1 DICER1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 USF1 AGO3;AGO1 TNRC6B CCND1 LIG1 ATP6V1H SMARCE1 TFAP2A DIAPH1 BIRC7 GPR143 TCF7L2 MCM5 CDKN2A MCM2 CDH2 ASAH1 SMARCB1 DCT ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 NTF3 PLCG1 NTRK3 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis DPM1 DOLK DPM2 DPM3 SRD5A3 GALM-2 GALE NUS1 GALT PGM1 GFPT1 MPI GNE DHDDS GALK1 PMM2 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 LEF1 TCF7L1 AXIN2 CTNNB1 MYC TCF7 TCF7L2 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 FLT3LG PIK3CA PTPN11 CDKN1A GOLGB1 GAB2 BCL2L1 TRIP11 GRB2 SPTBN1 FLT3 UBA52 CBL NOX4 MYO18A STAT5A STAT5B ETV6 PIM1 ZMYM2 RPS27A UBB;UBC HRAS PIK3R1 NRAS REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation ACTL6A DPF1 DPF2 DPF3 AKT2 SMARCC1 USF1 SMARCC2 CTNNB1 TYRP1 TYR MYO5A SYTL2 ACTB-1 PMEL MLANA MLPH SMARCE1 TFAP2A RAB27A IRF4 BCL7A SS18L1 BCL7C SOX10 BCL7B SMARCA2 LEF1 SMARCA4 MYRIP GPR143 ARID1A ARID1B MAPK14 SMARCD1 SMARCB1 DCT SMARCD2 SS18 SMARCD3 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 PRC1 DLG4 MYL6 PPP1R12B CDKN1B MYH14 CIT MYH11 RAC1 MYH10 PPP1R12A RHOA RHOC MYL12B RHOB MYH9 PPP1CB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids HADHB-1 MECR HADHA HADH ACADL ACADVL ACADM ECHS1 ACADS ACSM3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains PAG1 LCK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD3G PTPRJ HLA-DRA PTPRC PTPN22 CSK CD4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed SENP1 SUMO1 SENP5 SUMO3 SUMO2 SENP2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGF HDAC1 PRDM4 NGFR HDAC2 HDAC3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated APC NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC1 SNW1 MAMLD1 HDAC10 NCOR2 KAT2B KAT2A NCOR1 HDAC11 HDAC4 CREBBP HDAC5 HDAC8 HDAC9 NOTCH1 HDAC6 HDAC7 RBPJ MAML2 MAML1 TBL1XR1 MAML3 NOTCH2 NOTCH3 NOTCH4 HDAC2 HDAC3 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 GSK3B PRKACB-1 CSNK1A1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 GLI3 PSMA2-1 PSMA5 PRKACA-1 SEM1 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants FLT3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation FGF20 FGF23 FGF19 FGFR4 FGF6 FGF1 FGF4 FGF16 FGF9 FGF2 KLB FGF18 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism ABCC8 STX1A GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 CHRM3 AGPAT1 PRKAB2 GNG13 CACNB2 CACNB3 GNAQ CACNA2D2 GNB2 GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 MLX IQGAP1 GNAI1 GNAI2 CD36 KCNC2 PRKAG2 GCGR GCG PRKACA-1 PPP2R1A KCNS3 ADRA2C ADRA2A KCNJ11 ACACB ACACA MARCKS RAPGEF3 PRKCA VAMP2 RAPGEF4 PRKAR2B PPP2CB;PPP2CA CACNA1A CACNA1D PPP2R5D CACNA1C KCNB1 PPP2R1B CACNA1E ADIPOQ KCNG2 SYT5 FASN ACSL4 ACSL3 STXBP1 ACLY GNAS-1 ADCY9 PRKAR1B PRKAR1A STK11 ADCY4 ADCY3 ADCY2 INS;INS-IGF2 ADCY1 ADCY8 ADCY7 PFKFB1 ADCY6 ADCY5 PRKACB-1 PRKAR2A FFAR1 SNAP25 AKAP5 PRKAA2 ADIPOR1 ADIPOR2 GNGT1 TALDO1 PLCB3 GLP1R SLC2A1 TKT SLC2A2 PLCB1 AHCYL1 PLCB2 RAP1A ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation SPR NMT2 LYPLA1-1 ZDHHC21 CALM3;CALM1 CAV1 DDAH1 NOS3 CYGB HSP90AA1 NMT1 AKT1 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR52A5-2 OR2V2 OR11A1 OR8A1 OR8I2 OR10G9;OR10G7 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 LHX2 OR56B1-1 OR10W1 OR8B3;OR8B2-1 OR5B2 OR5D14 OR5D13 EBF1 OR52M1 OR10V1 OR4C12 OR6C3 OR5A2 OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 OR4D11 OR4D10 OR2Z1 OR6A2 OR9G4 OR4E1 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5B12 OR5AP2 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 OR4C3 OR3A2 OR3A1 OR8K3 OR8K1 OR4C11-1 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 OR6F1 OR2T2;OR2T35 OR51M1 OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 OR51A7 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 OR6Q1 OR11H1;OR11H12 OR52I1;OR52I2-1 OR4F21;OR4F16;OR4F29;OR4F3 OR9G9;OR9G1 OR7C1;OR7C2-9 OR51G2 OR51G1 OR1F1 OR2H2 OR4L1 OR5B3-13 OR6P1 OR10Q1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2AP1 OR2B11 OR4A47-3 OR51F2 OR5M9 OR51F1 OR2G6 OR4K5 OR4K3 OR5M3 OR4K2 OR4K1 OR10P1 OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 LDB1 OR11H4 OR2M4 OR4C13;OR4C46-2 OR6K3-1 OR1K1 OR4K17 OR1S1;OR1S2 OR4Q3 OR11H6 OR8G1;OR8G5 OR1J4 OR11G2 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR2K2 OR1I1 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR10C1 OR5B17-3 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 OR5T1 OR6V1 OR10G6 OR6C4-1 OR10K1-1 OR52W1 OR5AS1 OR4F5;OR4F17;OR4F4 OR2T6 OR13C9 OR2T1 OR13C8 OR2L13 OR4X1 OR9A4 OR51T1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 OR2Y1 OR8D4 OR56B4 OR8D1 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR56A4 OR10A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 OR8B8 OR2W1 OR8B4 OR13F1 OR12D3 OR5AU1 OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels KCNJ2 ABCC8 KCNJ12;KCNJ18 KCNJ3 KCNJ4 GNG10 GABBR2 KCNQ2 KCNQ3 GNG2 KCNJ5 GNG5 GABBR1 GNG4 KCNJ6 KCNJ10 ABCC9 GNG8 KCNJ9 KCNJ15 KCNK10 KCNJ16 KCNJ14 KCNK13 KCNK16 KCNK18-1 GNG13 KCNK17 KCNK2 GNB2 KCNK4 GNB1 GNB4 GNB3 GNB5 KCNK6 KCNK7 KCNK1 KCNN1 KCNN3 KCNN4 KCNC2 HCN4 HCN3 HCN2 HCN1 KCNS3 KCNJ11 KCND1 KCND2 KCND3 KCNB1 KCNG2 KCNK9 KCNMB1 KCNK3 KCNMB2 KCNMA1 KCNMB3 KCNMB4 KCNJ1 KCNJ8 KCNG1 KCNG3 KCNG4 KCNC1 KCNA1 KCNC3 KCNA2 KCNC4 KCNA3 KCNA4 KCNA6 KCNA7 KCNV1 KCNV2 KCNH1 KCNF1 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNB2 KCNAB1 KCNAB2 KCNAB3 KCNS1 KCNS2 KCNA10 KCNQ5 KCNQ4 KCNN2 GNGT1 KCNQ1 KCNA5 KCNH2 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC30A2 SLC30A8 SLC39A10 SLC30A5 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A4 SLC39A1 SLC39A3 SLC30A3 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE TLR3 TICAM1 TRAF3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening UBTF H2AC20 PHF6 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC1 H2AC14 H2BC21 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer TGFBR1-1 TGFBR2 FKBP1A TGFB1 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 IRS4 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 IGF1R PIK3R4 THEM4 IGF2 PDPK1 IGF1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT CALM3;CALM1 PPP3CA PPP3CB PPP3R1 FKBP1A NFATC2 NFATC3 NFATC1 PPIA BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 FGF20 FGF23 FGF2 FGF7 FGF22 FGF3 FGF10 PLCG1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling ABL2 CLASP1 ABL1 ROBO1 CAP1 CLASP2 SLIT2 CAP2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency BTD DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors LPAR3 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 LPAR1 LPAR2 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency CPS1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation TRAF6 IKBKB UBE2V1 IKBKG PELI1 CHUK UBE2N IRAK1 PELI3 PELI2 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs RAD23B UBB;UBC PRKN RAD23A JOSD2 VCP-1 JOSD1 ATXN3 RPS27A UBA52 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis DICER1 AGO4 AGO2 AGO3;AGO1 TARBP2 PRKRA TSNAX TSN DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FRS3 FGF4 NRAS FGF9 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly CASP5;CASP4 DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS ADAMTS2 ADAMTS3 ADAMTS1 ADAMTSL5 ADAMTSL4 ADAMTSL2 THSD7A ADAMTS8 ADAMTS6 ADAMTS7 ADAMTS9 SBSPON ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS19 ADAMTS17 ADAMTS13 ADAMTS16 ADAMTS18 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTSL3;ADAMTSL1 ADAMTS4 THBS1 ADAMTSL1 ADAMTS5 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events FUT8 MAN2A1 GSK3B ST6GAL1 MOGS OST4 ACE2 UBE2I RPN2 OSTC STT3A RPN1 CSNK1A1 STT3B GSK3A ST3GAL4 ST6GALNAC2 PRKCSH ST3GAL1 MGAT4A-1 ST3GAL2 ST3GAL3 SUMO1 SRPK2 EDEM2 PARP16 DDOST PARP14 SRPK1 PARP10 DAD1 MAN1B1 ST6GALNAC3 ST6GALNAC4 MAGT1 PARP6 PARP4 GANAB PRMT1 ANO8 ANO9 ANO6 GALNT1 ANO4 PARP9 MGAT4C ANO5 MGAT4B ANO2 PARP8 ANO3 ANO1 CANX ZDHHC20 TMPRSS2 MGAT5 ANO10 MGAT1 UBA52 MGAT2 FURIN ZDHHC9 RPS27A TUSC3 UBB;UBC ZDHHC5 ZDHHC8 ZDHHC2 GOLGA7-1 ZDHHC3 TMEM258 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation U2AF2 ASPH KDM8 OGFOD1 JMJD4 F9 JMJD7 RCCD1 JMJD6 RIOX2 ZC3H15 RPS23 RWDD1 ETF1 RPS6 RIOX1 DRG1 DRG2 RPL27A RPL8 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR EIF2AK2 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TASOR PPHLN1 RBM7 H2AC20 MORC2 MPHOSPH8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MTREX H2AC4 ATF7IP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZCCHC8 H2BC15;H2BC3;H2BC11;H2BC12 EHMT2 H2BC5 EHMT1 SETDB1 H2BC1 H2AC14 H2BC21 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage PUDP TK2 UCK1 TK1 DCK UPP1 TYMP UCKL1 CDA INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers FGF20 FGF23 INSR PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 CSNK2A1;CSNK2A3 BMI1 RING1 HDAC5 PSMD12 RNF2 PSMD11 PSMD14 HDAC7 PSMD13 REST CBX8 PSMA7 CBX6 PSMD8 PDE1C PHC2 PHC1 GRK2 PSMB6 PSMB7 CBX4 PSMD6 CBX2 PSMB4 PSMD7 PIP5K1A PIP5K1B PSMB5 PHC3 PSMB2 PIP5K1C PSMB3 PSMD2 EGF PSMD3 ERBB2 PLCG1 PSMB1 PSMD1 EGFR PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PSMA5 XIAP PRKACA-1 HGF SEM1 PSMA6 GAB1 PSMC5 PPP2R1A PSMA3 MET PSMC6 PSMA4 AREG PSMC3 PSMA1 PRKCE PSMC4 PSMC1 FGF7 FGF22 FGF3 FGF10 KIT NTRK3 AKT1 UBA52 TSC2 PRKCD KDM1A PRKCA PRKAR2B RPS27A UBB;UBC KPNA2 CASP9 PREX2 PDE1B PDE1A IER3 FLT3LG PDGFB CD19 EGR1 BAD CD28 SNAI1 SNAI2 ADCY9 STRN RCOR1 GAB2 PRKAR1B PHLPP2 PRKAR1A PHLPP1 IL33 CD86 IRAK1 KLB ADCY4 CD80 ADCY3 ATN1 SALL4 ADCY2 MAF1 INS;INS-IGF2 ADCY1 PDGFRB ADCY8 FGF19 ADCY7 FGFR4 ADCY6 AKT1S1 ADCY5 IL1RL1 PRKACB-1 TRAT1 RPS6KB2 FLT3 PIK3AP1 PRKAR2A GSK3A TRIM27 USP13 TNKS TNKS2 RNF146 FRK PIP4K2A PDPK1 OTUD3 PIP4K2B CAMKK1 PTEN CAMKK2 PIP4K2C TRAF6 FYN MYD88 PTPN11 IRAK4 WWP2 FOXO4 FOXO3 CALM3;CALM1 EPGN NBEA TRIB3 STUB1 TGFA FOXO1-1 IRS2 ATF2 SGK1-1 PRKCG ITPR1 ITPR2 LCK ITPR3 RRAGA RRAGC RRAGB SRC RRAGD EZH2 MAPKAP1 JUN CDKN1A CDKN1B RAC1 CHUK RPTOR NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF MBD3 SUZ12 RICTOR NTF3 GATAD2B GATAD2A PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG LAMTOR2 LAMTOR1 LAMTOR4 PPP2R5E LAMTOR3 LAMTOR5 VAV1 USP7 MDM2-2 SLC38A9 FGF2 GSK3B MECOM NEDD4 RHEB CHD4 CHD3 ESR1 THEM4 PRR5 CAMK4 EED MLST8 PPARG PIK3CD PIK3CG TP53 IRS1 PIK3R2 ESR2 PIK3CB NR4A1 PIK3R1 NR2E1 CAMK2B CAMK2D HDAC2 CAMK2A HDAC3 FRS2 HDAC1 PIK3CA CAMK2G PML MTOR TNRC6C MOV10 MTA1 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 TNRC6B CSNK2B RBBP7 MTA2 MTA3 MKRN1 NTRK2 BDNF AHCYL1 PRKX MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM19 SH3PXD2A ADAM12 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK3 FADD TLR3 TICAM1 CASP8 RIPK1 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm GATA4 BMP4 IHH FOXF1 SHH EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin SOS1 MMP3 PRKCA HRAS EGFR HBEGF NRAS INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 FBP1 MTA2 MTA3 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 G6PC1 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC21 H2BC1 CHD5 GATAD2B IKZF1 GATAD2A IKZF2 IKZF3 H2AC20 PHF6 H2AB2;H2AB3;H2AB1 ZMYND8-1 H2AZ2;H2AZ1 ZNF687 TCF19 ZNF592 ZNF827 H2AC4 NR2F2 CDK2AP2 CDK2AP1 ZNF532 PCK1 HDAC2 NR2C2 H2AC14 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 MTERF3 TFB1M RCC1L NGRN MRM2 MRM3 FASTKD2 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1 KCNE1;KCNE1B CACNA1C CACNG6 CACNG7 CACNB2 CACNG8 CACNA2D2 CACNB1 AKAP9-1 CACNG4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 APP NFKB2 TRAF6 TLR5 TP53 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER S100A12 N4BP1 JUN PPP2R1A USP18;USP41 MYD88 MAPK7 NFKBIB SAA2;SAA1 NKIRAS1 BTRC NKIRAS2 IKBIP IRAK4 ECSIT SKP1 TRAF2 PELI1 CHUK CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 FBXW11 TIFA HMGB1-1 MAP3K1 IKBKB IKBKG FOS UBA52 NFKBIA CUL1 MAPKAPK2 RELA TLR10 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat NCBP1 CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes ATP6V0B HVCN1 ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V1E2 ATP6V1B1 NOS1 ATP6V1G1 ATP6V1G2 NOS3 NOS2 ATP6V1H MPO ATP6V1G3 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 NCF1 ATP6V0A4 ATP6V0E2;ATP6V0E1 NCF2 ATP6V1D NCF4 ATP6V1C1 ATP6V1F LPO ATP6V0A1 ATP6V1C2 CYBB CYBA SLC11A1 TCIRG1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis RIPK3 MLKL CASP8 RIPK1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L WDR5 DPY30 RBBP5 KMT2D TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes TP53 PCBP4 CDKN1A ZNF385A GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 PRKAR2B GCGR GCG PRKACA-1 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants DUSP8 DUSP9 DUSP6 MAPK1 DUSP7 DUSP16 DUSP10 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT AKT2 CSNK2A1;CSNK2A3 CSNK1G2 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 NFATC1 PIP5K1B PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 SCRIB PSMC1 SKP1 CTNNB1 TCF7 CDC73 TERT LEO1 VPS29 BCL9L SOX3 TLE4 VPS35 VANGL2 TLE3 SOX6 TLE2 SOX7 TLE1 SOX4 AXIN2 TCF7L1 WLS PYGO1 WNT3A SOX13 BCL9 HECW1 PYGO2 VPS26A SOX2 CCDC88C RSPO2 XPO1 RSPO1 TLE5 RSPO4 AKT1 UBA52 TMED5 LGR6 LGR5 LGR4 CTNNBIP1 PRKCA KLHL12 CUL1 CBY1 YWHAZ DACT1 ZNRF3 RPS27A UBB;UBC MAP3K7 PRKCB TPTEP2-CSNK1E;CSNK1E DAAM1 RBX1 CAV1 CSNK1A1 TNKS TNKS2 RNF146 CUL3 CALM3;CALM1 ZRANB1 GNGT1 PLCB3 PLCB1 PLCB2 CTBP2 CTBP1 DVL1 DVL2 DVL3 H2AC14 USP8 WNT9A SFRP1 SFRP2 GNG10 WIF1 SOST GNG2 GNG5 GNG4 GNG8 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 SNX3 CREBBP GNB2 GNB1 USP34 GNAT2 PRKCG GNB4 KAT5 WNT5B GNB3 RYK-1 ITPR1 WNT5A ITPR2 ROR1 GNB5 SMARCA4 ROR2 ITPR3 NLK PPP3R1 H2AC20 WNT1 FZD1 FZD3 H2AB2;H2AB3;H2AB1 FZD2 FZD5 FZD4 FZD7 FZD6 FZD8 PARD6A ASH2L GNAO1 CLTB ARRB2 PPP3CA PPP3CB PRKG1 PRICKLE1 PDE6B PDE6A RSPO3 RAC1 H2AJ PFN1 RHOA WNT10B WNT10A CLTC H2BC5 CLTA AP2A1 H2BC1 AP2B1 AP2A2 AP2S1 AMER1 PPP2CB;PPP2CA RAC3 WNT8A WNT8B AXIN1 PPP2R5B PPP2R5A EP300 PPP2R5D PPP2R5C FRAT2 WNT7B PPP2R1B MEN1 APC WNT7A H2AC4 PORCN PPP2R5E SOX17 KMT2B LRP5 LRP6 GSK3B WNT11 DPY30 SOX9 WNT4 CHD8 H2BC21 WNT9B WDR5 WNT6 H2AZ2;H2AZ1 WNT2 WNT3 SMURF2 SMURF1 DKK1 DKK2 WNT2B DKK4 MYC CAMK2A HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 TRRAP AGO2 RBBP5 AGO3;AGO1 WNT16 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RUNX3 RNF43 H2BC15;H2BC3;H2BC11;H2BC12 SRY TCF7L2 KREMEN1 KREMEN2 RUVBL1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol PPIP5K1 IP6K1 PPIP5K2 NUDT4;NUDT4B IP6K3 ITPK1 NUDT11;NUDT10-1 IPPK NUDT3 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling IL1RL1 IL33 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1;UGT1A6 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) SLC6A19 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC UNC5A DCC UNC5B CASP3 CASP9 DAPK1-1 DAPK2 DAPK3 APPL1 MAGED1 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events GNG10 RAMP2 GNG2 GNG5 GNG4 GRK5 GNG8 PDE3B AVPR2 GNG13 DRD1 GNB2 GNB1 ADM IAPP DRD5 GNB4 POMC CALCA GNB3 ADRB1 ADRB2 GNB5 HTR4 HTR6 HTR7 HRH2 CALCRL GRK2 SRC TAAR8 GIP TAAR9 TAAR6 TAAR5 ARRB2 TAAR2 GNAI1 TAAR1 ADORA2A ADRB3 GNAI2 GCGR GCG PRKACA-1 SCT RXFP1 RXFP2 GPR176 GHRHR GPR15 MC4R GPR27 GPR25 GPR20 PTH1R GPR32 PTH2R MC3R GPR45 MC1R MC5R PRKAR2B GPR150 LHCGR FSHR SCTR GPHA2 TSHR ADM2 GPHB5 GPR83 GPR84 CALCB;CALCA RLN3 PDE1B INSL3 PDE1A PDE2A ADCYAP1 ADCYAP1R1 PDE11A VIPR1 PDE10A VIPR2 LHB PTGDR ITGB1 GNAS-1 GIPR ADCY9 CRHR1 PRKAR1B PRKAR1A PDE3A CRH ADCY4 ADCY3 GPBAR1 ADCY2 ADCY1 ADCY8 PTGER4 ADCY7 ADCY6 RAMP3 ADCY5 PTH PRKACB-1 PTGER2 PRKAR2A RLN2;RLN1 GHRH RAMP1 FSHB PDE8B PDE8A CRHR2 GRK3 CALCR GRK6 CYSLTR2 GNAT3 PDE4D-1 ADORA2B GNAZ GNAI3 GPER1 PDE4A PTGIR PDE4C GLP2R CGA MC2R PTHLH GPR39 PDE7B VIP PDE7A ARRB1 NPSR1 GNGT1 NPS P2RY11 ITGA5 GLP1R AVP TSHB SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis CERS1 CERS2 PPM1L SPHK2 OSBP KDSR SPNS2 FA2H ABCG2 VAPA VAPB CSNK1G2 MFSD2B SAMD8 SPTLC1 SPTLC3 SPTSSB SGMS1 SGMS2 SPHK1 CERS3 CERS4 ORMDL2 CERS5 PRKD3 CERS6 ORMDL3 PRKD2 DEGS1 PRKD1 DEGS2 ORMDL1 ABCC1 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 TREX1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades S100A8 TLR2 MYD88 TLR3 LY96 IRAK4 CHUK TICAM1 BTK TLR7 CD14 HMGB1-1 TIRAP TLR4 IKBKB IKBKG FGB FGA NFKBIA UNC93B1 FGG RELA TLR10 NFKB2 TRAF3 TLR6 S100A1 TLR5 NFKB1 CD36 TLR1 S100A9 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK ARNTL CLOCK CSNK2A1;CSNK2A3 CDK5 CSNK2B ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AB1 HSP90AA1 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD2;SMAD3 BCL2L11 FOXO3 SMAD4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction SOS1 PIK3CA PDGFB PTPN11 STAT3 GRB7 PDGFRB NCK2 CRK NCK1 STAT1 STAT6 STAT5A STAT5B BCAR1 SRC PIK3R2 PIK3CB PLCG1 RAPGEF1 HRAS PIK3R1 PDGFRA RASA1 CRKL NRAS RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling RUNX3 LEF1 TCF7L1 CTNNB1 MYC TCF7 TCF7L2 CCND1 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A;HSPA1B GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis ENO4 TPI1 GAPDH-1 PC SLC37A1 PGK1 FBP1 FBP2 PGAM1 PGAM2 ALDOC ALDOB ALDOA G6PC1 GAPDHS PCK1 G6PC2 GPI ENO1 G6PC3 ENO2 SLC37A4 PCK2 ENO3 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CBLIF AMN CUBN TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins GALNT1 PARP9 PARP8 CANX GSK3B ST6GAL1 MOGS UBE2I MGAT1 UBA52 GSK3A ST3GAL4 ST6GALNAC2 PRKCSH ST3GAL1 ST3GAL2 ST3GAL3 SUMO1 PARP16 PARP14 PARP10 RPS27A UBB;UBC ST6GALNAC3 ST6GALNAC4 PARP6 GANAB PARP4 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle FRS2 WDR6 FAM83B GOLGA3 ANKRD26;CCDC144A;LOC105375816 DST KIDINS220 TXNL1 ARHGAP35 SCRIB LEMD3 CKAP4 KTN1 NISCH VANGL1 PTPN13 DEPDC1B VANGL2 UBXN11 DLG5 KCTD13 CAV1 DSG1 PKP4 RBMX EPHA2 UHRF1BP1L ARHGAP1 KIF14 PLXND1 LRRC1 RND2 PRAG1 NUDC TFRC PIK3R2 PIK3R1 ALDH3A2 TNFAIP1 FRS3 ARHGAP5 FNBP1 MUC13 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol IMPA1 IMPA2 MIOX INPP5B INPP5A ISYNA1 INPP5J MTMR9 INPP4A OCRL SYNJ1 INPP4B INPP1 MTMR7 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation MAPKAPK5 BLM MDM2-2 CSNK2A1;CSNK2A3 STK11 CCNA2-1 CDK5 CCNA1 TAF9 PRKAB2 TP53RK PIN1 NOC2L MDM4 RAD9B KAT5 TAF9B CHEK2 CHEK1 RAD9A DYRK2 HUS1 TAF15 PRKAB1 EXO1 TAF12 TBP TAF13 TAF10 TAF11 SSRP1 TOPBP1 DNA2 RHNO1 TAF8 RFC5 RFC3 TAF7 RFC4 RFC2 TP53 TAF6 NUAK1 TAF5 TAF4 TAF3 ATRIP TAF2 TAF1 PRKAA1 BARD1 AURKB PLK3 TP53INP1 RBBP8 PRKAG2 TPX2 RAD17 ATM RAD50 ATR CSNK2A2 PRKAA2 PRKAG1 BRCA1 PRKAG3 SUPT16H CSNK2B RMI2 RMI1 TOP3A UBA52 WRN CDK5R1 AURKA RPA1 RPA2 HIPK1 CDK2 HIPK2 RPA3 RPS27A RAD1 TAF4B UBB;UBC TAF7L BRIP1 MRE11 MAPK14 MAPK11 NBN ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols NR1H4 CYP8B1 FDXR ARNT2 RXRA CYP7A1 CYP1B1 CYP11B1;CYP11B2 CYP39A1 CYP46A1 AHRR AHR CYP27A1 CYP21A2 CYP4V2 CYP51A1 ARNT CYP7B1 NCOA1 CYP19A1 NCOA2 FDX1 CYP11A1 POMC G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 CDK1 HDAC1 CDC6 TOP2A RBBP4 MAX CCNA2-1 CCNA1 LIN54 LIN37 LIN9 DYRK1A LIN52 PCNA CDC25A CDK2 MYBL2 E2F4-1 E2F5 TFDP1 RBL2 TFDP2 RBL1 CCNE2 CCNE1 MYC E2F1 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHOA RHOC RTKN LIN7B RHOB RHPN2 ROPN1;ROPN1B TAX1BP3 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription SNAI1 SNAI2 KLF4 STRAP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TWIST2 SP1 H2BC21 SMARCA4 FOXA2 H2AC20 EED H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 WT1 EZH2 TGIF2 ARID1A HDAC2 HDAC1 SIRT1 RBBP4 ZNF217 H2AJ TCF12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TLE1 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC1 KDM1A MPHOSPH8 ZMYM2 H2AC4 CTBP2 FOXQ1 CTBP1 DNTTIP1 ZBTB33 MAPK1 FOXP2 RB1 ZEB2 MAPK3 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 H2AC14 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors HRH3 HRH2 HRH4 HRH1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 CLDN2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 CLDN6 CLDN4 PSMB1 PSMD1 CLDN3 CLDN9 CLDN8 JAK1 CLDN7 ADRM1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PSMA5 XIAP CLDN23-1 SEM1 PSMA6 CLDN20 PSMC5 TYK2 CLDN11 PSMA3 CLDN10 PSMC6 CTNND1 MTBP PSMA4 CLDN15 RACK1 CLDN14 CBLL1 CLDN12 PSMC3 PSMA1 CLDN19 EPS15 CLDN18 PSMC4 CLDN17 PSMC1 CTNNB1 BIRC2 CLDN16 ADAM33 CANX CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 ADAM19 CDH24 SDK1 SDK2 CLDN22;CLDN24-1 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 PARD6G NECTIN4 MPP5 NECTIN3 NECTIN1 RPS27A CRB3 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 CLDN5 SNAI2 CDH1 JUP OST4 OSTC STT3A ANG JAK2 SP1 PRKCSH F11R DDOST PARD3 DAD1 CDC42 IL6ST GANAB CTSS FARP2 CTSB CTSV;CTSL IL6R FURIN CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 PARD6B PARD6A PRKCI SPCS3 SPCS2 SPCS1 BANP SIRT1 RAC1 H2AJ TCF12 CLDN1 ANGPTL4 ELMO1 DOCK1 SUZ12 H2BC5 H2BC1 SOX10 DNM2 MPHOSPH8 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 MDM2-2 CTNNA1 KLF4 STRAP TWIST2 H2BC21 VCL RNF19B EED WT1 H2AZ2;H2AZ1 ARID1A MYC HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 PATJ POMT1 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism PM20D1 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 TGFB1 SMAD4 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria ASL NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription HES1 MAMLD1 GZMH;GZMB-1 RBPJ MAML3 NOTCH2 MAML2 EP300 FCER2 MAML1 HES5 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation MARK3 ARAF RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 WDR83 PEBP1 IL17RD FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 LAMTOR2 ARRB2 MAP2K2;MAP2K1 LAMTOR3 RAP1A CSK MAPK1 HRAS BRAF MAPK3 KSR1 KSR2 RAP1B NRAS APBB1IP GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis FPGT GFUS GMDS FCSK SLC35C1 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 FGF20 SOS1 FGF23 FGF2 KLB FGF19 FGFR4 HRAS FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses GJC1 GJA10 GJD2 PANX1 PANX2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases MMP25 MMP24 CTSK TIMP2 KLK3;KLK2 CTSG TIMP1 CTSV;CTSL CTRB1;CTRB2 MMP7 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 TPSAB1;TPSB2;TPSD1 FURIN PLG SPOCK3 CMA1 PRSS3;PRSS2;PRSS1 ELANE KLKB1 COL18A1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC20 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC14A INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing STX1A EXOC8 P4HB EXOC7 MYO5A EXOC4 EXOC3 EXOC6 EXOC5 INS;INS-IGF2 EXOC2 EXOC1 PCSK2 RAB27A ERO1B KIF5C SLC30A8 SLC30A5 VAMP2 MYRIP KIF5B KIF5A PCSK1 CLTRN CPE DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A8 SLC30A5 SLC30A1 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 PTEN AGO3;AGO1 TNRC6B TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC28A2 SLC25A5 SLC25A4 SLC29A1 ARL2 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC25A6 ARL2BP SLC29A4 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin SOCS3 IRS1 PTPN11 STAT5A STAT3 STAT5B IRS2 JAK2 LEP CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants CBL GAB1 SOS1 PIK3CA HSP90AA1 RPS27A UBB;UBC EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS UBA52 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation HBA2;HBA1 HBD;HBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity RHOA ROBO1 MYO9B SLIT2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine FMO1 CSAD SUOX GOT2-1 TXN2 TST MPST CDO1 TSTD1 GADL1 ADO ETHE1 SQOR CTH SLC25A10 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response NUP133 NUP50 POM121;POM121C NUP54 GSK3B NUP42 HSPA2 NUP43 RAE1 RANBP2 NUP35 YWHAE HIKESHI CCAR2 NUP37 DNAJC2 DNAJC7 ST13;LOC107986532 RPS19BP1 HSPA4L HSPA14 HSPA13 ATM DNAJB1 HSPH1 BAG5 ATR DNAJB6 NUP107 SIRT1 BAG3 NUP188 BAG1 HSPA1L HSF1 HSPA4 HSPA6 HSPA12A HSPA12B HSPA5 NUP210 NUP93 BAG4 BAG2 HSPA1A;HSPA1B NUP205 AAAS HSPA9 NUP160 NUP85 NUP214 TPR NUP88 NUP155 RPA1 MAPKAPK2 RPA2 NUP153 RPA3 HSPA8 NUP62 MAPK1 MAPK3 NDC1 SEC13 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways SFN PSMC6 SMAD2;SMAD3 YWHAZ YWHAQ YWHAH PDPK1 YWHAG EP300 SMAD4 YWHAE YWHAB CAV1 UBE2I SP1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane PIKFYVE MTMR4 PIK3C3 MTM1 FIG4 MTMR2 MTMR7 PIK3C2A VAC14 PIK3R4 MTMR9 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK SOS1 PRKCA MAPK7 RPS6KA3 MMP3 RPS6KA2 RPS6KA1 EGFR MAPK1 HRAS GAST MAPK3 HBEGF NRAS CCKBR CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine ACSM1 ACSM2A;ACSM2B GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism NUP133 NUP50 HKDC1 POM121;POM121C NUP54 PGK1 FBP1 FBP2 PFKFB2 PFKFB1 PFKFB4 NUP42 PFKFB3 PRKACB-1 G6PC1 G6PC2 ENO1 G6PC3 ENO2 NUP43 ENO3 GNPDA1 ENO4 RAE1 GNPDA2 RANBP2 SLC37A1 NUP35 ALDOC ALDOB ADPGK ALDOA NUP37 SLC37A4 PRKACA-1 PPP2R1A NUP107 NUP188 BPGM NUP210 PC PGM2L1 NUP93 PFKL PGAM1 PGAM2 NUP205 PFKM AAAS PFKP GPI NUP160 NUP85 NUP214 TPR NUP88 GCKR NUP155 GCK TPI1 NUP153 PPP2CB;PPP2CA PPP2R5D GAPDH-1 HK2 PPP2R1B HK1 HK3 NUP62 GAPDHS PCK1 PCK2 NDC1 SEC13 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy MAP1LC3B2;MAP1LC3B-1 VPS18 VPS41 UVRAG VPS16 VPS45 VPS33A VPS33B TUFM VPS11 VPS39 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization MORF4L1-2 SUPT7L BRMS1 KAT6B MORF4L2 SNRPD2 HAT1 ENY2 SNRPD1 TAF5L KDM4C-1 ATXN7 EP400 SNRPD3 SMYD3 DMAP1 COPRS MRGBP RIOX2 TADA1 BRWD1 KDM5A KDM5B KDM5C VPS72 KDM6B MSL2 H2BC18 MSL1 KDM7A KDM3A KDM3B HDAC8 KDM4A KDM4B KDM4D SNRPE-2 USP22 MSL3-1 REST CLOCK NFKB2 PRMT1 MAFK NFE2L2 CTNNB1 CDC73 LEO1 AXIN2 PAX3 RPS2 KDM1A CHD9 CHD2 PHF21A SNRPF RCOR1 SNRPB HMG20B G6PC1 JAK2 BCL11B PHF10 SNRPG-2 SUPT16H SNRPA1 WDR61 SMARCB1 PCK1 EHMT2 EHMT1 H2AC14 SAP130 DPF1 PHF5A DPF2 DPF3 KAT8 SMARCC1 SNRPN SMARCC2 HCFC1 TAF9 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP ATF2 SETDB1 SS18L1 SETD1B KAT5 SETD1A SMARCA2 SMARCA4 TADA2A ZZZ3 H2AC20 TAF12 H2AB2;H2AB3;H2AB1 TAF10 EZH2 SSRP1 CBX3-1 PHF20 SUV39H1 MEAF6 ASH2L SGF29 NCOA1 NCOA2 SS18 ACTL6A NCOR2 KAT2B H2AJ KAT2A TCF12 ING5 NCOR1 AEBP2 PRMT5 BRD1 GPS2 SF3B1 MBD3 SUZ12 BRPF3-1 H2BC5 MCRS1 MBD2 H2BC1 BRD7 GATAD2B GATAD2A CDK4 ARID4B EP300 H2AC4 SAP30 TBL1XR1 KMT5A KMT2D KMT2A KMT2C KMT2B TCF4 KAT6A SMYD2-1 MBIP SUDS3 DR1 CTR9 RTF1 BRPF1 YEATS2 ACTB-1 MYOG TADA3 PAF1 FBP1 DHX15 MECOM MYOD1 DPY30 UBE2I CHD4 CHD3 CHD8 CHD7 BCL7A CHD6 CTCF NKD2 H2BC21 FAM124B BCL7C IGF2 BCL7B PWWP2B DDX46 DDX42 CHD5 IKZF1 WDR5 IKZF2 SUMO1 RBM17 IKZF3 KDM6A PHF6 MBD3L1 EED ZMYND8-1 DNMT3A CARM1 PWWP2A H2AZ2;H2AZ1 ADNP2 ARID1A ZNF687 ARID1B TCF19 ADNP ZNF592 ZNF827 SMNDC1 CBX1 U2SURP NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 DKK2 SMARCD1 SMARCD2 HDAC2 SMARCD3 NR2C2 HDAC3 HDAC1 SF3B4 SF3B5 MTA1 SF3B2 HDAC10 SF3B3 NQO1 RBBP4 TRRAP SF3B6 EPC1 RBBP5 SUPT20H SAP30L PRDM7;PRDM9 SF3A3 WDR77 SF3A1 JMJD6 SF3A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PADI3 CCND1 BICRAL PADI2 BICRA SAP18 PADI4 BRD9 PADI1 PADI6 RBBP7 PRDM16 MTA2 TADA2B MTA3 PHF2 SUV39H2 SMARCE1 SETD2 CHERP ATF7IP SETD3 SETD6 SETD7 H2BC15;H2BC3;H2BC11;H2BC12 PHF8 KANSL1 ING4 ING3 KANSL2 PRMT6 PBRM1 KANSL3 PRMT7 ACTL6B PRMT3 ASH1L PUF60 SUPT3H SNRPB2 TAF6L DOT1L RELA NSD3 NSD1 NSD2 BCL11A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 H2AC16;H2AC11 ELP6 KDM1B NFKB1 JADE1 ARID4A YEATS4 JADE3 JADE2 RUVBL2 RUVBL1 KMT5B ARID2 KDM2A KDM2B KMT5C ARID5B HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOC2 ALB CETP ABCG1 APOC3 APOE APOA1 LIPG LCAT AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0B ATP6V1B2 DEPDC5 ATP6V0C ATP6V1B1 SLC38A9 BMT2 ATP6V1G3 SEH1L RHEB WDR59 MIOS WDR24 ATP6V0E2;ATP6V0E1 RRAGA RRAGC RRAGB MLST8 RRAGD FNIP1 FNIP2 C12orf66 ITFG2 KPTN MTOR ATP6V1E1 SZT2 ATP6V1E2 ATP6V1G1 ATP6V1G2 FLCN RPTOR ATP6V1H ATP6V0D1 ATP6V0D2 ATP6V1A NPRL2 NPRL3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 CASTOR1 CASTOR2 LAMTOR2 SESN1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SESN2 SH3BP4 TCIRG1 SEC13 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H SSB NFIX POLR2L NFIA NFIB NFIC ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling RAPGEF3 YWHAZ RAPGEF4 RAP1GAP SIPA1 RAP1GAP2 RAP1A RAF1 YWHAB RASGRP2 RASGRP1 PRKACB-1 RAP1B PRKACA-1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system RPS14 RPS17 TBK1 RPS16 PTK2B RPS19 IL21 TNFRSF13C RPS18 AKT2 GBP2;GBP3;GBP1 AKT3 RPS11 B2M RPS10 RELB S1PR1 RPS13 VIM RPS12 CD40LG TNF STX4 IL4R IL13 VCAM1 IRF4 CCL3L1;CCL3L3;CCL3;CCL18 ITGB2 TNFSF13B POMC IRF8 SFN STAT6 APP STAT5A STAT5B NFKB2 POU2F1 RPS25 RPS27 CASP1 RPS29 SDC1 RPS20 RPS21 BATF RPS24 IL4 RPS23 IL5 PLCG1 JAK1 RIPK2 RAP1B PRKACA-1 HGF PPP2R1A TYK2 IL17RC TNFRSF1A BTRC HSPA1L TNFRSF14 IL17RA BIRC2 SKP1 BIRC3 HSP90AA1 CANX FBXW11 RPS27L RPS15A RPS3 SOX2 UBA52 RPS2 STAT1 STAT2 CUL1 CSF1 IL17F FAU ATF1 RPS27A MAP3K14 ELK1 IL17A EDA RPS6KA3 TNFRSF13B RPS6KA5 EDA2R TNFRSF8 KPNA2 RPS6KA2 UBB;UBC MAP3K7 TNFRSF4 RPS6KA1 GSDMD EDARADD MAP3K8 RPS9 MEF2A RPS7 TNFRSF12A MAP2K3 RPS8 TNFRSF1B MAP2K4 RPS5 EDAR MEF2C LTA RPS6 MAPKAPK3 TNFRSF25 LTB MAPK9 RPSA TNFRSF11B MAPK8 TNFRSF11A MAP2K7 HSP90B1 TNFRSF17 MAPK10 TNFSF18 TNIP2 TNFSF14 CDK1 CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 BCL2L11 CD27 UBE2V1 TNFSF8 STAT3 BCL2 LTBR IFNAR1 BCL2L1 IRAK1 IRAK2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E COL1A2 IL9 IL9R MAVS SQSTM1 JAK2 FLT3 UBE2N TAB3 TAB2 TAB1 ADAM17 RPS4X IRF1 RPS3A IRF2 IL23R IL23A IRF3 IL18 TRAF3 IL1A CDC42 IL1B TRAF6 IRF7 SH2B3 BECN1 RORC NOD1 NOD2 CAPZA1 EIF4A2 EIF4A1 IFNB1-4 PTPN11 CASP3 CTSG TIMP1 PTPN7 IL34 GAB3 EIF4E EIF2S2 FOXO3 EIF2S3;EIF2S3B PTPRJ ALOX15 EIF2S1 MMP1 NOS2 MMP2 MMP3 MMP9 PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 CD44 IL10 SERPINB2 LAMA5 ANXA2 MSN MIF TNFRSF18 FURIN RALA-1 SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 SPHK1 IL2RA TCP1 PTPN4 MT2A YES1 DUSP4 FOXO1-1 DUSP3 VRK3 DUSP6 DUSP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VEGFA ATF2 SMAD2;SMAD3 SMARCA4 IL2 IL3 JUNB CD36 TARBP2 PRKRA JUN MAPK7 CDKN1A UBE2D3-1 ARF1 CDKN1B RPLP0 FPR1 CRK FOS TNFSF11 CBL SOCS3 VAMP2 CSF2 PTPN1 EIF4A3 NPM1-2 MAP2K6 FCER2 THOC5 ACTB-1 FANCC KPNB1 OPRD1 BCL6 IL21R HSPA2 PIN1 LIFR PIK3CD SMAD7 BIRC5 YBX1 SOCS6 OPRM1 SOCS5 CAMK2B CAMK2D CAMK2A PML CAMK2G FASLG TRAF2 CASP8 SHC1-1 F13A1 ANXA1 LYN UBE2D3;UBE2D2 NFKBIA PTAFR SLA2 TSLP IFITM3;IFITM2;IFITM1 IL31RA IL18BP CCR2 IFNL2;IFNL3;IFNL1 MAP2K2;MAP2K1 EIF2AK2 STX3 RAPGEF1 CRLF2 MAPK1 SLA MAPK3 CRKL GBP5-1 CIITA TRIM68 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 SOS1 STX1A GRB10 IFNGR1 TRIM46 PIK3R3 IFNGR2 TRIM45 IL2RB P4HB TRIM35 TRIM38 TRIM31 IL36A IL36B TRIM29 TRIM26 BRWD1 TRIM14 TRIM10 CD4 IL36G EIF3C;EIF3CL MUC1 EIF1AY;EIF1AX IL1F10 LCN2 IL20 EIF3M IL25 EIF3K IL26 EIF3L IL24 EIF3I PSMD12 EIF3J IL11 EIF3G PSMD11 EIF3H IL15 PSMD14 EIF3E IL19 PSMD13 EIF3F IL16 SNCA EIF3D EIF3A PSMA7 EIF3B DNAJC3-1 PSMD8 PGGT1B MAP3K3 PSMB6 IL31 PSMB7 PSMD6 IL37 PSMB4 OSM PSMD7 IL18R1 PSMB5 PSMB2 PSMB3 RAG2 PSMD2 RAG1 PSMD3 PSMB1 PSMD1 IL36RN IFIT1 IFIT3 ADRM1 IFIT2 IL7R PSMC2-1 PSMA2-1 PSMA5 IL1RL2 SEM1 TEC PSMA6 CNTF PSMC5 PSMA3 MX1-1 PSMC6 TOLLIP PSMA4 PSMC3 PSMA1 IL10RB PSMC4 CLCF1 PSMC1 CSF3 IL5RA GSTO1 IL13RA2 IL13RA1 ILF2 RAF1 HSPA1A;HSPA1B IL1RN IFIT5 IL1R2 AKT1 STXBP2 NUP214 LIF PRKCD YWHAZ MAPKAPK2 LBP IL11RA OASL OAS1 OAS3 ITGAM IL20RA IL20RB IL22RA2 IRF5 IL22RA1 HSPA8 MAPK14 RNASEL MAPK11 CTF1 ZEB1 FLNB EIF4G1 NANOG;NANOGP8 TXLNA FSCN1 IL1RAPL1 PTPN9 FLT3LG PTPN5 PTPN2 EGR1 RBX1 IFI35 RSAD2 SAMHD1 GRAP2 GAB2 IL33 CD86 OSMR CD80 IP6K2 IL17C IL1RL1 MID1 ISG20 IL7 IRF6 IRF9 CNTFR SNAP25 KPNA4-1 FN1 TRIM8 TRIM6 TRIM5 TRIM2 SYK TRIM3 HAVCR2 EBI3 HCK IL27 IL6ST CRLF1 HRAS FNTA IL27RA FYN FCGR1A CSF3R LGALS9C;LGALS9;LGALS9B ALPK1 NCAM1 NLRX1 NRAS AGER S100A12 FLNA N4BP1 USP18;USP41 NDN MYD88 NFKBIB PTPN20 SAA2;SAA1 NUP107 PTPN23 NKIRAS1 NKIRAS2 NUP188 IKBIP IL3RA EIF4E2 IRAK4 PLCG2 PELI1 PTPN14 PDE12 LRRC14 KPNA1 SP100 USP14 NUP210 PELI3 PELI2 DHX9 IFNLR1 NLRC5 IL17RE TIFA BST2 IL17RB HMGB1-1 GRB2 NUP93 IL22 IL18RAP SIGIRR IRAK3 NUP205 ABCE1 AAAS IL6R NUP160 NUP85 TPR NUP88 NUP155 TALDO1 NUP153 PTGS2-2 ELOC-1 NUP62 ELOB CCR5 NDC1 SEC13 ABL2 PTPN18 IL10RA NUP133 NUP50 POM121;POM121C CSF2RB NUP54 CSF2RA MCL1 GSTA3;GSTA5;GSTA1;GSTA2 CEBPD CISH IRS2 AIP NUP42 NCK1 PRL PRLR GHR SOCS2 SOCS1 NUP43 IL1R1 DUS2 RAE1 LCK RANBP2 SOS2 SRC FAAP24 LOC105377022;FANCB FAAP100 CENPX NUP35 FANCM FANCL FANCA FANCE CSK FANCG FANCF NUP37 CXCL8 FNTB;CHURC1-FNTB CHUK INPPL1 BLNK UBA7 HSPA5 CXCL2;CXCL3;CXCL1-1 DDX58 CCL13;CCL2 EIF2AK3 CCL11 ISG15 PTPN13 UBE2L6 IFI44L CCL4L2;CCL4L1;CCL4 HERC5 IFIH1 IKBKB GBP6 CCL5 TRIM25 ARIH1 IKBKG ATF6 CCL19 FKBP5 CCR1 CCL22 CCL20 ITGAX CXCL10 TRIM21 PPP2CB;PPP2CA ILF3 PIM1 PPP2R5A KPNA7 PPP2R5D KPNA5 KPNA3 PPP2R1B VAV1 ADAR PPM1B RHOU MAOA CA1 ITGB1 GATA3 INPP5D FGF2 NEDD4 UBE2I RORA PIAS1 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 SUMO1 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ACTG1 HLA-DRA PPIA GBP7;GBP4 IRS1 TP53 PIK3R2 PIK3CB MTAP PIK3R1 PSMB8 IL2RG HIF1A PTPRZ1 CUL5 MYC CENPS-CORT;CORT;CENPS JAK3 PIK3CA PTPN6 HMOX1 TGFB1 CCND1 KRAS ALOX5 UBA3 EIF4G3 EIF4G2 EIF4E3 HSPA9 CSF1R UBE2D1 PTPN12 RELA UBE2E1 NFKB1 IL6 RNF7 IFI30 ICAM1 RPS15 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation MGST3 MGST1 MGST2 CNDP2 GSTT1 GSTO2 GSTT2B;GSTT2 HPGDS GSTO1 GGT1 GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 GSTK1 GSTA3;GSTA1 GGT5 GGT7 CHAC2 GGT6 CHAC1 GSTP1 GGCT GCLC GCLM ESD OPLAH GSTM4 GSTM3 AKR1A1 GSTM1;GSTM2-1 GSS GSTA4 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation PIK3CD PIK3CG PIK3CA PIK3R2 PIK3CB LOC102723996;ICOSLG PIK3R3 PIK3R1 PIK3R6 PIK3R5 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors CHRM2 CHRM1 CHRM4 CHRM5 CHRM3 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development RPS14 RPS17 SPTBN2 RPS16 RPS19 CLASP2 RPS18 LIMK2 LIMK1 CSNK2A1;CSNK2A3 RPS11 RPL10A RPS10 RPS13 RPS12 SDC2 CNTN1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 DLG1 RPS23 ERBB2 PLCG1 NRP1 EGFR RPL36AL-1 PRKACA-1 GAB1 MET MYO10 HSP90AA1 RPS27L RPS15A GPC1 RPS3 CYP51A1 UBA52 NELL2 RPS2 SLIT3 RPL18A KIF4B;KIF4A ST8SIA2 FAU AGRN RPS27A RPS6KA3 RPS6KA5 CLASP1 RPS6KA2 UBB;UBC RPS6KA1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CNTN6 CHL1 ITGA2 ITGA10 ANK1 UNC5A GRIN2B DCC UNC5B UNC5C UNC5D NTN1 ADAM10 HSP90AB1 RPS4X RPS3A PSEN1 NCSTN CDC42 COL9A1 ST8SIA4 COL9A3 COL9A2 LAMC1 PTPN11 RPL15-1 MMP2 MMP9 PITPNA RPS6KA6 CFL1 PAK2 DLG3 MSN ITGA5 YAP1-1 LAMB1 WWTR1 CACNA1H YES1 GRIN1 MYH9 SMARCA4 LDB1 RPL10;RPL10L-1 POU3F1 MAPK7 TEAD1 RPLP0 ARHGAP35 RAC1 RPLP2 RPL36-1 RHOA DOK1 DOCK1 SOX10 POU3F2 ITGA2B PSEN2 APH1A APH1B PLXNA4 ABL1 FLRT3 EIF4A3 RPL22L1 CASC3 ITGAV CDK5 ACTB-1 PSENEN RPL37A-1 MAG GSK3B RBM8A MAGOH;MAGOHB UPF3B RNPS1 PIK3CD TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 HDAC2 RPL13A-1 CXCL12 DOK2 SHC1-1 PRKCQ ITGB3 LYN TIAM1 CDK5R1 RPL23A MBP MAP2K2;MAP2K1 ADGRV1 MAPK1 SEMA5A MAPK3 MPZ ADGRG6 HMGCR SOS1 GRB10 PIK3R3 MSI1 HOXA2 ISL1 COL4A5 GSPT2 GSPT1 LHX3 LHX2 LHX4 LHX9 USP33 ROBO1 UPF2 ETF1 ZSWIM8 SLIT1 PRX RPL27A PSMD12 PSMD11 PSMD14 PSMD13 WASL PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PSMD3 ANK3 PSMB1 PMP22 PSMD1 EPHA4 ADRM1 ROCK1 PSMC2-1 PSMA2-1 COL4A2 PSMA5 COL4A1 COL4A4 SEM1 PSMA6 COL6A2 PSMC5 PSMA3 COL4A3 PSMC6 COL6A1 PSMA4 PSMC3 PSMA1 PSMC4 COL6A3 PSMC1 COL6A6 COL6A5 EPHA2 PRKCA RPL12-1 TRIO ITSN1 HSPA8 PABPC1;PABPC3 EIF4G1 MYL6 RBX1 NGEF TREM2 GAB2 TYROBP NUMB RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 PRKACB-1 RPL34 PRKAR2A SDCBP RPL8 ARPC1B ARPC1A RPL9 RPL6 RPL7 RPL35 RPL38 DAG1 RPL39 RPL21 RPL23 RPL22 HRAS FYN RASA1 CACNA1G CACNA1I NRTN RPL24 NCAM1 NRAS CACNA1S RPL27 PRNP PSPN RPL26 GFRA2 RPL29 GFRA4 RPL28 ARTN FARP2 CNTN2 RPL3L RPLP1-2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D PLXND1 ITGA1 SEMA7A SEMA3A ALCAM CRMP1 SCN11A SEMA3E SCN10A RRAS AGAP2 PLXNA2 L1CAM PLXNA3 LYPLA2 SEMA4A DSCAML1 CD72 SHC3 SEMA4D RAP1GAP PTPRC DAB1 FES PTPRA PLXNB3 CNTNAP1 SPTB ITGA9 ELOC-1 NTN4 ABLIM1 RPL11 NEO1 ABLIM2 RPL14 ABLIM3 NFASC ELOB RPL13 EPHB6 RPL18 RPS6KA4 RPL17 CACNB1 EPHB2 RPL19 CACNB4 EPHB1 EPHB4 SCN1B PLXNA1 EPHB3 ABL2 SCN1A SRGAP3 EPHA5 NCBP1 SRGAP2 EPHA7 SRGAP1 EPHA6 ARPC4 EPHA8 ARPC5 ANK2 SHTN1 KCNQ2 KCNQ3 ARPC2 EPHA1 ARPC3 EPHA3 SPTBN4 SPTBN5 PLXNB1 EPHA10 MYL12A SCN3B SCN3A CD24 SCN2A SCN2B NRP2 VLDLR CAP1 CXCR4 NCK2 GFRA3 IRS2 RGMB CACNB2 NCK1 RGMA CACNB3 RELN CAP2 ACTR2 SCN9A NRCAM DSCAM DOK4 DOK5 SCN8A DOK6 EFNA5 EFNA4 EVL TLN1 SREBF2 SPTA1 EFNB2 PFN2-1 EFNB1 SOS2 EFNB3 ROCK2 EFNA1 SRC EFNA3 EFNA2 NCBP2-1 HJV SCN5A GAP43 DCX SCN4A CLTB SCN4B SHANK3 LAMA1 PPP3CB SCN7A PDLIM7 CLTCL1 RPL7A NCAN DRP2 PFN1 GRB7 UTRN RPL35A KALRN MYL12B SPTBN1 CLTC PTK2 CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 LAMA2 SPTAN1 GIT1 CACNA1D VAV3 CACNA1C RHOC VAV2 RHOB SIAH2 SIAH1 ARHGEF7 ITGB1 ROBO2 RET PAK1 PAK3 PAK5 PAK4 MYO9B SLIT2 GFRA1 BUB1B-PAK6;PAK6 VASP ARHGAP39 GDNF ENAH ACTG1 PIK3R2 PIK3CB PIK3R1 CUL2 AKAP5 FRS2 ARHGEF28 PIK3CA CSNK2A2 SCD5 RANBP9 MYH14 MYH11 EZR MYH10 CSNK2B RPL5-1 RDX DLG4 ACTR3-1 RND1 NAB1 NAB2 ARHGEF11 ARHGEF12 SH3KBP1 EGR2 RPS15 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes CYB5R1 CYB5R4 CYB5RL HBA2;HBA1 CA1 AQP1 CA2 CA4 HBD;HBB CYB5R2 RHAG SLC4A1 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system OPN1MW3;OPN1MW2;OPN1MW;OPN1LW TTR NAPEPLD LRAT RDH5 STRA6 RDH12 OPN1SW RBP4 RLBP1 ABCA4 RBP1 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling EGR1 IFI35 RSAD2 GBP2;GBP3;GBP1 IFNAR1 SAMHD1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KPNB1 IP6K2 IRF4 ISG20 SOCS1 IRF6 IRF9 IRF8 IRF1 IRF2 IRF3 IRF7 IFIT1 IFIT3 JAK1 PSMB8 IFIT2 IFNB1-4 TYK2 USP18;USP41 PTPN11 MX1-1 PTPN6 KPNA1 ISG15 BST2 ABCE1 IFIT5 UBA52 SOCS3 STAT1 STAT2 PTPN1 OASL OAS1 OAS3 RPS27A IFITM3;IFITM2;IFITM1 IRF5 UBB;UBC EIF2AK2 RNASEL ADAR NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation ADCYAP1R1 ADORA2A NTRK1 ADCYAP1 NTRK2 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation FGF23 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication ORC2 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 KPNA6 KPNB1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 ORC5 H2BC5 ORC4 ORC6 ORC1 H2BC1 H2AC14 ORC3 H2BC21 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 BLK ELF1 ELF2 PAX5 CBFB METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids NR1H4 PLAAT1 PTGIS G0S2 PLA2G4A NR1H3 PLAAT3 PLAAT2 PLAAT5 GPCPD1 PLAAT4 HADHA ARSD-1 PITPNM1 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 B4GALT6 MGLL PLA2G1B TM7SF2 B4GALT5 AGPAT1 PPP1CC PON3 AGPAT2 PTGES3-1 ALPG;ALPP;ALPI-1 HPGD SELENOI PON2 AGPAT3 AGPAT4 GPAT4 PON1 AWAT2 GPAT3 LTC4S GPAT2 CEPT1 CDIPT SAR1B PLA2G10;LOC100652777 PLA2G2F BCHE CSNK1G2 PLA2G2D SGPP2 PIK3R4 PLA2G2E SGPP1 AGK POMC PNPLA8 PIKFYVE INSIG2 MBOAT7 INSIG1 MBOAT1 DDHD2 ALOX5AP ST3GAL2 MTM1 MBOAT2 ST3GAL3 DDHD1 ETNPPL OSBPL9 GPAM LPCAT4 ETNK2 RAB4A LPCAT3 OSBPL7 ETNK1 OSBPL6 LPCAT2 OSBPL3 OSBPL2 PNPLA3 CHPT1 M6PR LPIN1 LPIN2 SYNJ2 LPIN3 PNPLA2 SYNJ1 NFYA-1 RAB5A GAL3ST1 PIK3C2G PIK3C2A PPP1CB PIK3C2B PRKACA-1 HMGCS2 LBR GGPS1 FAAH2 APOA2 APOA1 APOA5 ALOXE3 CYP51A1 RAB14 VAPA VAPB SEC24D-1 GBA2 CPT1A SLC51A SLC51B CPT1B TIAM2 CYP2U1 SLC22A5 LHB HELZ2 UGCG SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CAV1 CYP7B1 ACBD5-1 GDPD1 GDPD3 GDPD5 CYP7A1 SPTSSB CBR4 ACOT2;ACOT1 PIK3C3 PTGES2 SEC23A NFYB NFYC GRHL1 SEC24B SEC24A HADH SEC24C IDI1 IDI2 ALOX15 ALOX12 CYP4F3;CYP4F2;CYP4F12;CYP4F11 AMACR PI4KA PI4KB SPHK1 CYP2R1 LSS THRAP3 LIPE VAC14 GBA FAM120B MED1 ACSL1 MED4 MED6 MED7 NSDHL ALDH3B2;ALDH3B1 PEX11A STARD3 STARD4 CCNC-1 STARD5 STARD6 PPARGC1A RUFY1 PPARGC1B CREBBP CIDEC MTMR1 HACD1 MTMR2 MTMR3 ABCB4 MTMR8 MTMR9 MTMR4 HACD3 MED16 HACD2 MED17 MED12 MTMR6 MED14 HACD4 MED13 MTMR7 MED10 CD36 HSD11B1 HSD11B2 NCOA1 UGT8 NCOA2 NCOA6 ELOVL5 NCOA3 ABCA1 B3GALNT1 MED27 ARF1 MED23 NCOR2 AACS NCOR1 MED24 ELOVL1 ELOVL4 MED20 ELOVL2 PLIN2 ANGPTL4 ELOVL3 PLIN1 GPS2 ELOVL6 ELOVL7 PTGR2 SUMF2 SUMF1 BDH2 BDH1 FABP4 MED31-1 PTGS1 EP300 GC TBL1XR1 FASN GK FABP9 FABP1 ACSL4 FABP2 ACSL3 FABP3 HSD3B1;HSD3B2 MED30 FABP5 FABP6 FABP7 MORC2 PECR CDK8 HMGCS1-1 HPGDS OSBP SULT2A1-4 KPNB1 CYP19A1 ACAT2 ACAT1 SIN3A PMVK THEM5 THEM4 HACL1 SRD5A2 SRD5A1 SRD5A3 B3GALT4 SLCO1A2 ABCD1 FHL2 PIK3CD PIK3CG ME1 ARNT SLC25A17 ACSS3 SMARCD3 HDAC3 ST6GALNAC5 ST6GALNAC6 PPM1L HSD17B13 HSD17B12 LRP2 HSD17B11 SCD SLC25A20 THRSP MMAA ACAD11 ACAD10 PTGR1-1 ARSA PIK3R3 PHYH-4 PIK3R6 PIK3R5 ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSG SCP2 HMGCLL1 CTSA PRKAB2 TPTE;TPTE2 ACER2 ACER1 ACER3 CH25H RGL1 MOGAT3 MOGAT2 MOGAT1 TECR AKR1B1 FAR1 FAR2 ARV1 CLOCK SPTLC1 ACADL SPTLC3 AGMO ACADM ACADS PIP5K1A PIP5K1B LTA4H PIP5K1C STARD3NL GSTM4 PRXL2B CYP2J2-1 LGMN MTMR10 AKR1D1 MTMR12 RXRB MTMR14 PLEKHA1 MED19 PLEKHA2 PRKAG2 MED15 ACAA1-1 MED18 PLEKHA5 SMPD3 PLEKHA6 MED11 PLEKHA3 PLEKHA4 SMPD2 PPP1CA SMPD4 PLEKHA8 SMPD1 TSPO ACAA2 EHHADH-1 CYP46A1 SPHK2 SBF1 MED26 PCCA GGT1 MED29 SBF2 PCCB MED22 DPEP2 ACACB MED25 DPEP1 ACACA CYP21A2 FUT2 MED21 FUT1 AGPS EBP ACSBG1 CYP11A1 ACSBG2 PPARD GGT5 FDPS SAMD8 MAPKAPK2 ABCB11 CHD9 CPT2 A4GALT CRAT SLC27A1 FADS2 NUDT19 FADS1 ACLY MVD SLC27A3 SLC27A2 SLC27A5 MVK HMGCL NRF1 NPAS2 MBTPS1 CYP24A1 KDSR MBTPS2 BMX PRKACB-1 SP1 TBXAS1 FDXR CYP1B1 OSBPL1A PIP4K2A ALAS1 PIP4K2B PTEN MMUT PIP4K2C ACOT9 CUBN ACOT8 MECR ACOT7 CERS3 MED8 CERS4 MED9 CERS5 CERS6 FDX1 CERS1 TNFRSF21 ACOT4 CERS2 PRKAA2 AWAT1 CDK19 FA2H TSPOAP1 MID1IP1 CYP4B1 CYP1A1 CERK SERPINA6 ECI1 PIP4P1 STS LDLRAP1 MFSD2B BAAT CYP39A1 TRIB3 PTGS2-2 NEU2 ASAH1 NEU3 ASAH2 NEU1 SC5D B4GALNT1 DECR2 DECR1 SLC10A1 SLC10A2 MED13L AGT FIG4 AHR FABP12 CROT SREBF1 SREBF2 ABHD5 CYP4F22 HSD17B3 HSD17B4 PSAP FITM1 ESRRA FITM2 DHCR24 HSD17B7 TECRL HSD17B8 ALB DHCR7 CYP17A1 RAN HSD17B1 ORMDL2 HSD17B2 ORMDL3 HEXB GM2A PNPLA7 HEXA ORMDL1 GLB1L3 GPX1 GLB1L2 CYP8B1 GPX4 NUDT7 GLB1L NDUFAB1 GLB1 PNPLA4 PNPLA5 PNPLA6 CBR1-1 ARSB INPPL1 MSMO1 TXNRD1 PTPN13 ENPP6 ENPP7 ACOT11 ACOT12 ACOT13 FAAH ACSM3 GDE1 PTGDS SACM1L ACSL6 ACSL5 INPP4A CYP27A1 DHRS7B PLPP6 INPP4B OXCT1-1 PLPP3 PLPP2 PLPP1 PTGES DEGS1 DEGS2 TNFAIP8 CYP27B1 ACOXL AKR1B15;AKR1B10 SGPL1 INPP5F INPP5D INPP5E INPP5J ACOX2 INPP5K ACOX3 SCAP PIAS4 CIDEA ALOX15B STAR UBE2I GK2 VDR NR1H2 TGS1 RORA GLIPR1 HSD3B7 ANKRD1 TNFAIP8L1 TNFAIP8L3 RXRA TNFAIP8L2 GALC SUMO2 CYP11B1;CYP11B2 CARM1 PPARG PPARA GLA PI4K2B ECHS1 B3GNT5 PIK3R2 PIK3CB LPGAT1 PITPNB CPNE7 CPNE6 PIK3R1 PRKD3 LCLAT1 PLB1 PRKD2 PLA2G2A-1 LIPI PRKD1 LIPH PI4K2A JMJD7-PLA2G4B;PLA2G4B ALOX12B CPNE3 MFSD2A DGAT2 ARNTL MIGA2 PCYT2 PIK3CA MIGA1 DGAT1 STARD7 ARNT2 CSNK2A2 OLAH GPD1L-1 PISD ST3GAL5 SCD5 PLA2G15 ABHD3-2 CGA GNPAT PHOSPHO1 FDFT1 GPD2 NR1D1 GPD1 MCAT CSNK2B SQLE PGP PLBD1 PLA2R1 SPNS2 PLA1A OCRL CYP2D6;LOC107987479;LOC107987478-1 CDS1 CYP2C9;CYP2C19 ABHD4 EPHX2 PPT1 ALOX5 CHAT CYP1A2 PLD4 PLA2G3 PPT2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG2 CYP2E1 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 ACBD7 PLD2 ACBD6 PGS1 ACBD4 PTDSS2 PTDSS1 PTPMT1 MCEE OSBPL8 ACSF3 TMEM86B CHKB ACSF2 OSBPL5 CHKA STARD10 DGAT2L6 MTF1 CRLS1 PLIN3 PEMT ACADVL AHRR CDS2 ABCD3 SLC44A5 ACHE MED28-1 SLC44A3 HADHB-1 SGMS1 SLC44A4 SGMS2 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A ABCC3 ABCC1 PLA2G4D PLA2G4E SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions SLC25A11 SLC16A8 SLC16A3 SLCO2A1 SLC5A7 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC10A6 BSG SLC5A8 SLC16A7 EMB SLC16A1 SLCO1A2 SLC22A12 SLC44A5 SLC44A3 SLC22A8 SLC44A4 SLC44A1 SLC44A2 SLC25A1 SLC17A5 SLC22A6 AVP SLC5A12 SLCO4C1 SLCO2B1 SLC16A2 SLC13A5 SLC13A2 SLC13A3 SLCO1C1 SLCO4A1 SLC25A10 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs FLT3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 VCP-1 SHH PSMB4 RPS27A PSMD7 SYVN1 DERL2 ERLEC1 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 OS9 PSMD3 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis PRIM2 PRIM1 POLA1 POLA2 POLD3 POLD4 POLD2 RFC5 RFC3 RFC4 RFC2 RFC1 POLD1 PCNA MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport MICU3 PMPCA MICU2 MICU1 MCU SLC8A3 VDAC2-1 AKAP1 VDAC3 STOML2 MCUB VDAC1 SPG7 PHB MAIP1 PHB2 PARL AFG3L2 LETM1 SMDT1 SLC8B1 YME1L1 PMPCB NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway RARG MED1 NCOR2 NR1D1 NCOR1 NR2F1 RARB HNF4G NR0B2 NR2F6 RXRG HNF4A THRB VDR NR1H2 RORA ESR1 NR2C1 NR4A2 NR5A1 PPARD AR RXRA RARA PGR PPARG PPARA ESRRA NRBP1 ESR2 NR4A1 THRA RORC NR2E1 RORB RXRB NR2C2AP NR2C2 ESRRB ESRRG NR1D2 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria PAH DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o DPM1 DPM2 DPM3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 MBIP TASP1 KAT8 PHF20L1 RBBP5 DR1 KAT2B HCFC2 KAT2A YEATS2 HCFC1 TADA3 WDR82 PAXIP1 AKAP8L PSIP1 DPY30 OGT-1 PAGR1 KANSL1 MCRS1 KANSL2 SETD1B KANSL3 SETD1A WDR5 TADA2A ZZZ3 KDM6A PHF20 ASH2L MEN1 SGF29 BOD1L2;BOD1 KMT2D KMT2A KMT2C NCOA6 KMT2B BOD1L1 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis BCAN VCAN DSE DCN CHST15 CSPG5 UST NCAN CHST14 DSEL BGN RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB APEX1 LIG3 XRCC1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation NUP133 DYNC1LI1 DYNC1LI2 KIF18A BUB1 NDC80 RANGAP1 CLASP2 CENPN-2 MIS12-1 BUB1B CDCA8 CDC20 SKA1 PPP1CC SKA2 BUB3 MAD2L1 DYNC1I1 SPDL1 NUP43 B9D2 SPC24 SPC25 RANBP2 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP NSL1 RPS27 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 NUP37 SGO2 AURKB CENPS-CORT;CORT;CENPS MAPRE1-1 PPP2R1A CENPT NUP107 CENPU KNL1 ZW10 CENPF CENPH CENPI TAOK1 DSN1 CENPK CENPL CKAP5 EML4 CENPM NEK9 RCC2 NEK6 NEK7 ZWINT XPO1 CENPO NUP160 CENPP AHCTF1 PAFAH1B1 NUP85 CENPQ DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E CLIP1 MAD1L1 DYNC1H1 NDE1 ITGB3BP PLK1 SEC13 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly APOC2 MTTP P4HB APOA2 APOC3 APOE APOB SAR1B APOA1 APOA4 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 FGF20 SOS1 FGF23 HRAS FGF1 FGF4 FGF16 NRAS FGF9 FGF2 FGF18 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs ABRAXAS2 MYSM1 PSMD14 STAMBPL1 STAMBP H2AC20 KAT2B BRCA1 EP300 RPS27A H2AC16;H2AC11 H2AC4 UBB;UBC NLRP3 BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCC3 BARD1 STAM UBA52 H2AC14 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis RFX2 RFX3 CCNO TNRC6C MOV10 TP73 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 GRHL3 TNRC6B GRHL2 DEUP1 GMNC FOXJ1 MYB NOTCH1 DLL1 E2F4-1 E2F5 TFDP1 GMNN GRHL1 MCIDAS BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism SLC10A1 NR1H4 CYP8B1 SLC10A2 FABP6 SLC27A2 SLC27A5 CYP46A1 OSBP ACOX2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 STARD5 CYP7B1 HSD3B7 CH25H RXRA AMACR CYP7A1 OSBPL1A OSBPL9 BAAT OSBPL7 CYP39A1 SLCO1A2 ABCB11 OSBPL6 ABCD3 HSD17B4 OSBPL3 OSBPL2 ACOT8 CYP27A1 ALB SLC51A SLC51B AKR1D1 NCOA1 NCOA2 ABCC3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 PSMB1 PSMD1 JAK1 ADRM1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 TYK2 PSMA3 PSMC6 CTNND1 MTBP PSMA4 RACK1 CBLL1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 BIRC2 ADAM33 CANX CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 ADAM19 CDH24 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 NECTIN4 NECTIN3 NECTIN1 RPS27A UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 SNAI2 CDH1 JUP OST4 OSTC STT3A ANG JAK2 SP1 PRKCSH DDOST DAD1 CDC42 IL6ST GANAB CTSS FARP2 CTSB CTSV;CTSL IL6R FURIN CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 SPCS3 SPCS2 SPCS1 BANP SIRT1 RAC1 H2AJ TCF12 ANGPTL4 ELMO1 DOCK1 SUZ12 H2BC5 H2BC1 SOX10 DNM2 MPHOSPH8 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 MDM2-2 CTNNA1 KLF4 STRAP TWIST2 H2BC21 VCL RNF19B EED WT1 H2AZ2;H2AZ1 ARID1A MYC HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 POMT1 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK3 PANK1 DCAKD AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) DERL3 DERL1 PRKAB2 PSMD12 PSMD11 PSMD14 PSMD13 PRKAB1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 ERLEC1 PSMB5 CD274 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PRKAA1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PRKAA2 PSMC4 PRKAG1 PSMC1 PRKAG3 UBA52 ERLIN1 ERLIN2 VCP-1 RPS27A DERL2 RNF5 UBB;UBC OS9 RNF185 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex RBX1 GSK3B CSNK1A1 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 HDAC1 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CTNNB1 TCF7 TLE4 TLE3 TLE2 TLE1 TCF7L1 ZRANB1 TLE5 UBA52 CUL1 AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D TCF7L2 PPP2R5C RPS27A FRAT2 PPP2R1B APC PPP2R5E UBB;UBC CTBP2 CTBP1 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) DAXX ATRX SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT KIT G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events ADRA2C GNG10 ADRA2A GNAS-1 GNG2 PRKCE ADRA2B GNG5 ADCY9 GNG4 GNG8 ADCY4 ADCY3 ADCY2 RGS20 ADCY1 ADCY8 PRKCQ ADCY7 ADCY6 ADCY5 GNG13 GNB2 RGS17 GNB1 RGS19 PRKCG GNB4 RGS16 GNB3 GNGT1 PRKCD PRKCA GNB5 GNAT3 RGSL1 GNAI1 GNAZ GNAI3 GNAI2 PRKCH RGS4 PRKCB CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) DHCR24 DHCR7 SC5D EBP LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors LTB4R2 GPR17 LTB4R CYSLTR1 CYSLTR2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol INPP5B PLCG2 PLCD3 INPPL1 PLCD4 INPP5D PLCD1 INPP5J CALM3;CALM1 OCRL PLD4 PLCH1 PLCH2 PLCE1 ITPK1 ITPKB PTEN ITPKC PLCB3 PLCB4 ITPKA PLCB1 PLCB2 PLCZ1 SYNJ1 PLCG1 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity USP8 CBL MET PTPN1 PTPN2 EPS15 SH3GL2 SH3KBP1 PTPRJ RPS27A HGS UBB;UBC SH3GL3 STAM SH3GL1 STAM2 LRIG1 UBA52 HGF ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation ALDH2 ADH5 ALDH1B1 ADH4 ACSS2 ADH1C;ADH1B;ADH1A ALDH1A1 ACSS1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions DCC NTN1 DSCAML1 DSCAM RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking RHOQ GOPC CFTR VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 AVPR2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 RAB11FIP2 ADCY5 GNG13 MYO5B PRKACB-1 GNB2 PRKAR2A GNB1 RAB11A AQP4 GNB4 GNB3 AQP2 GNGT1 AQP3 GNB5 AQP1 PRKAR2B AVP PRKACA-1 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins PRSS3;PRSS2;PRSS1 DEFA6;DEFA4;DEFA5 CD4 ART1 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination NEIL3 H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPG H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 OGG1 H2BC1 H2AC14 H2BC21 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway IFNB1-4 TBK1 SIKE1 IRF3 EP300 DDX58 TRAF3 IRF7 RNF135 IFIH1 TRIM25 IKBKE MAVS CREBBP RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants NF1 SPRED3 SPRED2 SPRED1 HRAS NRAS SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation TASL IRF5 IKBKB IKBKG SLC15A4 CHUK SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) SOS1 PIK3CA NTF3 BAX SRC IRS1 PLCG1 HRAS PIK3R1 NELFB PTPRO NTRK3 PTPRS NRAS SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin GAB1 SOS1 PIK3CA EPO STAT5A STAT5B PIK3R5 PLCG2 PIK3CD PIK3CG SHC1-1 PIK3CB VAV1 RAPGEF1 PLCG1 EPOR HRAS PIK3R1 IRS2 CRKL JAK2 LYN NRAS CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII CBL GAB1 SOS1 PIK3CA HSP90AA1 EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network SCOC RAB6A COG4 VAMP4 SYS1 COG3 GCC1 COG2 RGP1 GOLGA1 ARFIP2 IGF2R GCC2 ARL1 RABEPK RAB6B NAA30 NAA35 NAPB NAA38 TMF1 NAPG STX10 ARFRP1 VPS51 VPS53 VPS52 RAB9A VPS54 COG1 RAB9B GOLGA4 PLIN3 NAPA M6PR TGOLN2 NSF STX16 VAMP3 RHOBTB3 STX6 VTI1A COG8 COG7 RIC1 COG6 USP6NL COG5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling SMAD2;SMAD3 PPP1CA PMEPA1 TGFB1 RPS27A PPP1CC SMURF2 SMURF1 TGFBR1-1 MTMR4 TGFBR2 UBB;UBC UCHL5 SMAD7 STRAP PPP1R15A USP15 NEDD4L STUB1 XPO1 PPP1CB UBA52 BAMBI GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL GAA AGL-1 PHKG1 PHKB PHKG2 CALM3;CALM1 PGM1 GYG2 GYG1 PYGB PHKA1 PHKA2 PYGM REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C NPAS4 MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose HK1 GMPPB GMPPA PMM1 MPI PMM2 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity CDK6 CDK4 CCND3 CCND2 CCND1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins CPA3 ATP6AP2 AGT GZMH-1 ENPEP CTSG CPB1 CTSD ACE MME CMA1 CES1 REN ACE2 CTSZ CPB2 ANPEP RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development HES1 ABL1 ZNF521 WWTR1 YES1 CBFB SATB2 COL1A1 HDAC4 UCMA HEY1 MAF IHH HEY2 SP7 HDAC6 AR SRC YAP1-1 RBM14 SMAD1 SMAD4 SMAD6 MAPK1 RB1 MAPK3 GLI3 GLI2 HDAC3 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry TMPRSS2 ACE2 CTSV;CTSL VCP-1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells PTF1A HNF1B FGF10 ONECUT1 NKX6-1 PDX1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses STX1A PRKAB2 CACNA2D2 BCHE SLC6A4 GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 SLC18A3 PRKAG2 PRKACA-1 SLC5A7 UNC13B RAB3A SYT1 PRKCA SYN3 CPLX1 SYN2 SYN1 RIMS1 PPFIA1 PRKAR2B PPFIA4 SLC18A2 PPFIA3 PPFIA2 RPS6KA3 RPS6KA2 KPNA2 RPS6KA1 HSPA8 PRKCB ARL6IP5 NAAA ADCY9 PRKAR1B PRKAR1A GRIN2A ADCY4 ADCY3 MYO6 GRIN2B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A SNAP25 PDPK1 CAMK1 CAMKK1 CAMKK2 GNAT3 HRAS GNAI3 NRAS COMT PRKAA2 GRIA2 CALM3;CALM1 TSPOAP1 RPS6KA6 CHRNB2 ACTN2 CHRNA2-1 CASK CHRNA1 CHRNB4 CHRNA9 CHRNA3 LIN7A CHRNB3 LIN7C GRIN2C CHRNA5 GRIN2D CHRNA4 GRIN3B CHRNA6 GRIN3A GNAL SLC32A1 DLG2 SLC6A13 GNGT1 DLG3 ABAT NBEA GABRB3 SLC6A1 GABRB2 ALDH5A1 GABRB1 GRIK5 RASGRF1 GRIK3 GRIK4 GRIK1 GRIK2 PLCB3 NRGN GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 PLCB1 PLCB2 NPTN NEFL SLC1A1 HTR3A HTR3B LRRC7 SLC1A2 SLC1A3 LIN7B CHRNA7;CHRFAM7A PPM1E PPM1F NCALD GLRA1 CHRND CACNB1 GLRA2 CACNB4 CACNA2D1 GLRA3 SLC1A6 CACNA2D3 CHRNG CHRNE CACNA1B SLC1A7 KCNJ2 KCNJ12;KCNJ18 KCNJ3 GABRQ SLC38A2 KCNJ4 GABRA2 GNG10 GABBR2 GABRA1 SLC38A1 GNG2 KCNJ5 GABBR1 GNG5 GNG4 KCNJ6 KCNJ10 GABRA6 GNG8 GABRA5 KCNJ9 GABRA4 GABRA3 KCNJ15 RASGRF2 KCNJ16 GRIN1 GLRB APBA1 GAD1 GAD2 GNG13 CACNB2 CACNB3 GNB2 GNB1 PRKCG GNB4 GNB3 GNB5 PRKAB1 SRC GNAI1 GNAI2 KIF17 PRKAG1 SLC22A2 GLS2 SLC22A1 RAC1 PRKAG3 NRG1 SLC17A7 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 VAMP2 GLUL GIT1 CACNA1A SLC6A12 SLC6A11 LRTOMT CACNA1E MAOA MDM2-2 CAMK4 GLS PRKAA1 CAMK2B CAMK2D CAMK2A AKAP5 SLC6A3 CAMK2G DNAJC5 CHAT DLG4 ACHE ALDH2 PRKX MAPK1 MAPK3 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AB1 PPP1CA FURIN CSNK2A2 CSNK2A1;CSNK2A3 HSP90AA1 PPP1CC CSNK2B SPCS3 HSPA8 SPCS2 SPCS1 KPNB1 SEC11A SEC11C XPO1 PPP1CB SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 GCKR NUP155 GCK NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis MEF2D MTERF1-1 HELZ2 TFB1M GABPA MED1 TFB2M PPRC1 NRF1 TFAM-1 HCFC1 POLRMT POLG2 TWNK PERM1 PPARGC1A PPARGC1B SSBP1 TGS1 CREBBP ATF2 RXRA CAMK4 ALAS1 CARM1 PPARA ESRRA NCOA1 NCOA2 NCOA6 SMARCD3 HDAC3 ATP5F1B CRTC1 ACSS2 NCOR1 NR1D1 CALM3;CALM1 SIRT4 SIRT5 IDH2 SIRT3 GLUD1;GLUD2 SOD2 CHD9 CYCS-1 TBL1XR1 MEF2C CRTC2 CRTC3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs HPGD LTA4H PTGS2-2 ALOX5 ALOX15 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 SHTN1 NUMB EZR RPS6KA6 CLTC CLTA AP2A1 DPYSL2 AP2B1 RDX AP2A2 DNM1 MSN DNM2 DNM3 AP2S1 SH3GL2 L1CAM KIF4B;KIF4A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 RPS6KA4 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport COG4 COG3 COG2 DYNC1LI1 SPTBN2 KDELR1 BET1L DYNC1LI2 ANK2 GOLGB1 SPTBN4 ANK1 SPTBN5 GOSR2 DYNC1I1 CAPZA3 INS;INS-IGF2 ACTR10 CAPZB TMEM115 ARFGAP3 GOLGA2 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 SPTA1 DCTN1 NSF TMED2-1 ANK3 RAB1A RAB1B CAPZA1 CAPZA2 ACTR1A STX5 YKT6 KDELR2 ARF1 COPB2 COPA COPE TMED3 TMED7 TMED9 COPZ2 GORASP1 COPZ1 NAPB ARF5 TMED10 SPTBN1 USO1 NAPG GBF1 DYNC1I2 ARCN1 DCTN2 COPG2 FOLR1 COPG1 DCTN3 BET1 COPB1 SPTAN1 NAPA CD59 CD55 SPTB GOSR1 ARFGAP1 DYNC1H1 COG8 COG7 COG6 KDELR3 COG5 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade GP1BA FGG ANO6 TPST2 F2 TPST1 F5 F8 VWF F9 F10 F11 GP5 GP9 PROC GGCX PROS1 FGB FGA GP1BB KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization KRT16;KRT14 KRT6B;KRT6C;KRT6A KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRTAP26-1 KRTAP3-1 KRT10-2 KRTAP3-2;KRTAP3-3-1 KRTAP19-5 KRT4 KRT2 KRT8 KRT7 KRT5 KRT9 KRTAP13-1;KRTAP13-2 KRT24 KRT23 KRT20 KRT33A;KRT33B;KRT31-2 KRT28 KRT27 KRT26 KRT25 KRT32 KRT39 KRT36 KRT13 KRT12 KRT19 KRT18 KRT17 DSG2 KRT15 KRTAP24-1 KRT71 KRT79 KRT78 KRT77 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP11-1 KRT82 KRT80 KRT85 KRT84 DSP SPRR3 CSTA KLK5 PCSK6 EVPL KLK8 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 TGM1 CASP14 DSG1 LIPJ PKP4 SPRR1A;SPRR1B LIPN LIPM PRSS8 LIPK KRT1 TGM5 ST14 CDSN PERP SPINK6 SPINK5 KLK13 KLK14 KAZN CELA2B;CELA2A LCE6A PKP2 PKP1 LORICRIN DSG3 PKP3 SPINK9 DSG4 DSC1 IVL DSC2 DSC3 CAPNS1 JUP CAPN1 FURIN KRTAP27-1 KRTAP16-1 KRT81;KRT83-1 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 KRTAP4-3 KRTAP13-4;KRTAP23-1;KRTAP13-3-1 KRT3;KRT76 KRTAP29-1 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 KRTAP8-1 KRTAP9-4;KRTAP9-3;KRTAP9-8;KRTAP9-7;KRTAP9-6;KRTAP9-2;KRTAP9-9-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 KRTAP10-8 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds PTGIS MAOA NR1H4 MTARC1 FMO1 FMO2 AADAC ALDH1B1 FMO3 CYP26B1 PAOX CYP27B1 CYP26A1 ADH1C;ADH1B;ADH1A AHR PTGES3-1 CYP24A1 CYP2S1 AIP CYP7B1 CYP19A1 POMC TBXAS1 HSP90AB1 FDXR RXRA CYP1B1 CYP7A1 CYP4F22 CYP11B1;CYP11B2 CYP2C18-1 CBR3 CYP2J2-1 ARNT NCOA1 NCOA2 FDX1 CYP2B6 CYP2W1 CYB5R3 CYP8B1 ADH5 ADH4 ARNT2 NQO2 ACSS2 CYP46A1 ACSS1 BPHL CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP4B1 ALDH3A1 CYP21A2 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP51A1 CYP2E1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP11A1 EPHX1 CYP39A1 PTGS1 AHRR CES3 CES2 CMBL CES1 ALDH2 CYP27A1 CYP2F1 CYP2R1 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 POR CYP2U1 ALDH1A1 AOC3 MAOB AOC1 MTARC2 AOC2 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants CAMK2G MARK3 ARAF CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF MAPK3 KSR1 KSR2 CAMK2B CAMK2D CAMK2A RAP1B NRAS APBB1IP G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma GNB3 GNGT1 GNB5 GNG10 PDPK1 PIK3R6 GNG2 PIK3R5 GNG5 AKT2 GNG4 AKT3 GNG8 RHOA PIK3CG GNG13 GNB2 GNB1 AKT1 GNB4 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation NCBP1 CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators COLEC10 C1S C1R FCN2;FCN1 MASP1 C1QC COLEC11 C1QB CRP MBL2-1 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER STX5 SEC24A AREG TGFA SEC24C MCFD2 SERPINA1 CTSC LMAN1L GOSR2 MIA2 MIA3 TMED10 LMAN2L SAR1B LMAN2 CTSZ COL7A1 CNIH1 CNIH2 FOLR1 CNIH3 SEC24D-1 F5 F8 GRIA1 CD59 TMED2-1 SEC22B SEC23A LMAN1 PREB SEC24B MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation MRPS17 C12orf65 GFM1 MRPS15 MIEF1 MRPS16 MALSU1 MTFMT MRPS14 MRPS11 MTIF2 MRPS12 MTIF3 MRPL38 MRPS36 MTRES1 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 NDUFAB1 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 TUFM OXA1L GFM2 MTRF1 MTRF1L MRRF LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome HDAC1 CALM3;CALM1 CAMK4 TBL1XR1 GPS2 NCOR2 NCOR1 SIN3A PRKACA-1 HDAC3 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) TYK2 PTPN11 UBE2D3-1 STAT3 CSF3 GAB2 KRAS GRB2 SHC1-1 JAK2 LYN SOCS1 UBE2D3;UBE2D2 UBA52 SOCS3 STAT1 UBE2D1 STAT5A STAT5B RPS27A SYK UBB;UBC HCK RNF7 ELOC-1 JAK1 ELOB CSF3R CUL5 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ITGB1 ITGA5 FN1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids SLC10A1 NR1H4 SLC10A2 MED1 TM7SF2 NSDHL STARD3 STARD4 STARD5 STARD6 SAR1B CREBBP CH25H POMC INSIG2 INSIG1 SREBF1 AKR1B1 SREBF2 ARV1 OSBPL9 GPAM OSBPL7 OSBPL6 HSD17B3 OSBPL3 HSD17B4 OSBPL2 DHCR24 HSD17B7 STARD3NL ALB NFYA-1 DHCR7 CYP17A1 RAN LGMN HSD17B1 AKR1D1 HSD11B1 HSD17B2 HSD11B2 NCOA1 NCOA2 NCOA6 CYP8B1 LBR GGPS1 TSPO CYP46A1 MSMO1 ACACB ACACA CYP21A2 CYP51A1 ELOVL6 EBP CYP11A1 FDPS SEC24D-1 CHD9 ABCB11 CYP27A1 PLPP6 SLC51A GC SLC51B TBL1XR1 FASN HSD3B1;HSD3B2 MVD LHB HELZ2 FABP6 SLC27A2 CYP27B1 SLC27A5 AKR1B15;AKR1B10 MVK HMGCS1-1 MBTPS1 OSBP ACOX2 CYP24A1 SCAP MBTPS2 PIAS4 KPNB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UBE2I STAR CYP7B1 CYP19A1 VDR ACAT2 TGS1 HSD3B7 SP1 PMVK SRD5A2 FDXR SRD5A1 SRD5A3 RXRA OSBPL1A CYP7A1 SUMO2 CYP11B1;CYP11B2 SLCO1A2 CARM1 PPARA CUBN ACOT8 SEC23A NFYB NFYC FDX1 SMARCD3 SEC24B SEC24A SEC24C CGA IDI1 FDFT1 IDI2 SQLE TSPOAP1 HSD17B12 LRP2 HSD17B11 SERPINA6 SCD STS LDLRAP1 AMACR BAAT CYP39A1 MTF1 ABCD3 CYP2R1 LSS SC5D ABCC3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins CDK1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AURKB PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CDC14A ANAPC15 ANAPC16 CUL1 UBE2D1 AURKA ANAPC10 CCNB1 ANAPC11 CDK2 PTTG1;PTTG2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 PLK1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 GNB3 GNGT1 GNB5 ARHGEF6 GNG10 GNG2 GNG5 GNG4 PAK1 GNG8 CDC42 GNG13 GNB2 GNB1 GNB4 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism GLUD1;GLUD2 RIMKLA KYAT1 RIMKLB GLS GOT2-1 OAT PYCR1 PYCR2 GLUL GLS2 PYCR3 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines MTHFD2 SHMT2 SHMT1 ST20-MTHFS;MTHFS MTHFD1L SLC19A1 MTHFR SLC25A32 ALDH1L1 ALDH1L2 FOLR2 DHFR2;DHFR MTHFD2L SLC46A1 MTHFD1 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism HPRT1 PNP-1 APRT ADA DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 PRELP OMD ACAN KERA FMOD CHST6 LUM OGN MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system MRC1 UBB;UBC TLR2 B2M RPS27A UBA52 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC26A1 SLC35B3 SLC26A11 SLC35B2 PAPSS2 PAPSS1 SLC26A2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9;CYP2C19 EPHX2 CYP2J2-1 CYP1A1 CYP1B1 CYP1A2 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins SRGAP2 NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 FMNL3 FMNL1 PPP1CC BUB3 FMNL2 MAD2L1 SPDL1 NUP43 RANBP2 EVL PFN2-1 SRF NSL1 RPS27 NUP37 MAPRE1-1 PPP2R1A KNL1 ZW10 RAC1 PFN1 RHOA DSN1 SCAI CKAP5 RCC2 ZWINT XPO1 AHCTF1 PAFAH1B1 DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E RHOC RHOD DYNC1H1 RHOB NDE1 PLK1 MRTFA DYNC1LI1 DYNC1LI2 KIF18A ITGB1 DAAM1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 ACTB-1 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B ACTG1 INCENP CDC42 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SGO2 AURKB CENPS-CORT;CORT;CENPS CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM DIAPH1 CENPO NUP160 CENPP NUP85 DIAPH3 CENPQ CLIP1 MAD1L1 ITGB3BP DVL1 DVL2 DVL3 SEC13 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) ISY1;ISY1-RAB43 RBX1 COPS4 COPS2 CDK7 MNAT1 POLR2A POLR2B POLD1 POLR2C POLR2D POLR2G ZNF830 POLR2I RFC5 TCEA1 RFC3 RFC4 RFC2 GPS1 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 LIG1 POLR2F POLR2H POLK POLE POLR2L RFC1 LIG3 ERCC3 PCNA UBA52 ERCC5;BIVM-ERCC5 PPIE ERCC2 DDB1 GTF2H1 GTF2H3 ERCC6 GTF2H4 RPA1 XPA RPA2 AQR COPS7B COPS7A POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 PRPF19 POLD2 RPA3 RPS27A XRCC1 POLE4 CUL4A UBB;UBC COPS3 ELL COPS6 COPS5 ERCC4 POLE2 ERCC1 POLE3 COPS8 CCNH CUL4B USP7 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LPL AKR1B15;AKR1B10 APOB APOA2 APOA1 APOA4 PNLIP LRP1 TTR LRAT BCO2 LRP2 BCO1 GPC1 LRP8 SDC4 GPC3 APOC3 SDC2 GPC2 RBP4 SDC3 GPC5 RBP2 GPC4 RBP1 HSPG2 APOC2 GPC6 RETSAT LRP10 RDH11 AGRN LRP12 SDC1 APOM LDLR PLB1 APOE CLPS GPIHBP1 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations SLC35A1 SLC35A4 MGAT5B-1 FKRP B4GAT1 POMK CRPPA CHST10 DAG1 B3GALNT2-2 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN POMT2 POMGNT2 POMT1 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle ABL2 BCR SRGAP2 ITGB1 AMIGO2 NOXO1 PAK1 PGRMC2 NOXA1 ABR SNAP23 NCKAP1L PAK4 GIT2 MCAM CAV1 NOX3 MPP7 FERMT2 NOX1 JAG1 ESYT1 ARHGAP1 ARHGAP6 DSG2 EMD ARHGAP39 SYDE1 CDC42 ARHGAP42 CDC42EP1 VAMP3 SLITRK3 ARHGDIB PIK3R2 NHS SLITRK5 CYBB CYBA PIK3R1 WASF2 LMAN1 ARHGAP5 ARHGAP21 BAIAP2 LBR YKT6 ARHGAP17 ARHGAP15 BAIAP2L1 OPHN1 TMPO ARHGAP35 MCF2 LEMD3 VANGL1 ABI2 DEPDC1B GARRE1 TAOK3 OCRL RAB7A ARHGAP26 ABI1 EPHA2 ARHGAP32 PAK2 DIAPH3 TIAM1 NCF1 NCF2 DOCK10 NCF4 STBD1 RAC3 CYFIP1 GIT1 NCKAP1 SWAP70 WASF1-1 VRK2 TRIO TFRC ARAP2 LAMTOR1 ARAP3 ERBIN RAPGEF1 VAV2 PREX1 SLC1A5 RACGAP1 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL PIP5K1B TPTEP2-CSNK1E;CSNK1E CSNK2A2 DVL1 CSNK2A1;CSNK2A3 DVL2 DVL3 CSNK2B DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis JUN GOLGA2 CDK5R1 CDC25A CDC25B BCL2L11 APP SOD2 C1QBP FASLG FOXO3 CDK5 CDKN2A PRDX2 CAPNS1 TP53 CAPNS2 PRDX1 LMNB1 YWHAE CAPN2 CAPN1 CAST CDC25C TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFRSF13C LTBR TRAF2 BIRC2 BIRC3 TRAF3 MAP3K14 CD40LG TNFRSF12A LTA TNFSF11 LTB TNFRSF11A TNFSF13B TNFSF14 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production SMPD3 SMPD2 TNF RACK1 TNFRSF1A NSMAF ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway TRAF6 TIFA UBB;UBC MAP3K7 TAB3 TAB2 ALPK1 RPS27A UBA52 TAB1 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 ITGB4 PSMD6 PSMB4 PSMD7 ILK PARVA PSMB5 TESK1 PSMB2 CLDN2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 CLDN6 CLDN4 PSMB1 PSMD1 CLDN3 CLDN9 CLDN8 JAK1 CLDN7 ADRM1 RSU1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PARVB PSMA5 XIAP CLDN23-1 SEM1 LIMS4;LIMS1 PSMA6 CLDN20 PSMC5 TYK2 CLDN11 PSMA3 CLDN10 PSMC6 CTNND1 MTBP PSMA4 CLDN15 RACK1 CLDN14 DST CBLL1 CLDN12 PSMC3 PSMA1 CLDN19 EPS15 CLDN18 PSMC4 CLDN17 PSMC1 ITGA6 CTNNB1 BIRC2 CLDN16 FLNC ADAM33 PLEC CANX LIMS2 CD151 CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 ADAM19 FBLIM1 CDH24 SDK1 SDK2 CLDN22;CLDN24-1 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 PARD6G NECTIN4 MPP5 NECTIN3 NECTIN1 RPS27A CRB3 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 CLDN5 SNAI2 CDH1 JUP OST4 OSTC FERMT2 STT3A ANG JAK2 SP1 PRKCSH COL17A1 F11R DDOST PARD3 DAD1 CDC42 IL6ST LAMC2 GANAB CTSS FLNA FARP2 CTSB CTSV;CTSL IL6R LAMA3 FURIN LAMB3 CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 PARD6B PARD6A PRKCI SPCS3 SPCS2 SPCS1 BANP SIRT1 ACTN1 RAC1 H2AJ TCF12 CLDN1 ANGPTL4 ELMO1 DOCK1 SUZ12 H2BC5 H2BC1 PXN SOX10 DNM2 MPHOSPH8 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 ARHGEF6 ITGB1 MDM2-2 CTNNA1 KLF4 STRAP TWIST2 H2BC21 VCL RNF19B VASP EED WT1 H2AZ2;H2AZ1 ARID1A MYC HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 PATJ POMT1 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A1 SLC26A3 SLC26A11 SLC26A7 SLC26A9 SLC26A6 SLC26A2 SLC26A4 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission DLG2 DLG3 DLG4 CAMK2G CAMK4 CAMK1 GRIN2A GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 PPM1E PPM1F CAMK2B GRIN2C CAMK2D GRIN2D CAMK2A DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA ABAT ALDH5A1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling IL10RA TYK2 CXCL8 STAT3 TNFRSF1A TIMP1 IL10RB CSF3 FPR1 CD86 CXCL2;CXCL3;CXCL1-1 FCER2 CCL13;CCL2 CD80 CCL4L2;CCL4L1;CCL4 TNF CCL5 CCL19 IL1RN IL12B IL12A IL1R2 CCL3L1;CCL3L3;CCL3;CCL18 CCR1 CCL22 IL10 IL1R1 CCL20 LIF PTAFR CSF2 CXCL10 CSF1 IL18 IL1A IL1B PTGS2-2 CCR2 IL6 TNFRSF1B JAK1 CCR5 ICAM1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18-1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism ENTPD8 PNP-1 GDA SAMHD1 AGXT2 NT5C2 UPB1 ITPA DPYD NUDT5 TYMP NT5C NT5E DNPH1 NT5M NT5C1A NT5C1B;NT5C1B-RDH14 UPP1 ENTPD1 ENTPD2 XDH ENTPD3 DPYS NUDT16 ENTPD4 ADPRM NUDT15 ENTPD5 ENTPD6 ENTPD7 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways ARPC4 ARPC5 GNG10 GNG2 ARPC2 GNG5 ARPC3 GNG4 NOXA1 GNG8 YES1 CD163 PLK2 GNG13 NCK1 RHBDF2 MYH9 GNB2 ACTR2 GNB1 GNB4 GNB3 ITPR1 WNT5A ITPR2 GNB5 ITPR3 WASL MEFV NFKB2 PYCARD P2RX7 PSTPIP1 FZD7 CASP1 TXNIP SUGT1 GNAI1 PLCG1 GNAI2 WASF2 WASF3 BAIAP2 PRKACA-1 JUN RAC1 MYO10 BTK MYO5A MYO1C GGT1 DPEP2 DPEP1 ELMO1 ELMO2 CRK DOCK1 PTK2 GGT5 PRKAR2B CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 GSDMD VAV1 VAV2 MAPK14 MAPK8 ABL1 TXN GNAS-1 WAS NOXO1 ADCY9 PRKAR1B PRKAR1A ACTB-1 ADCY4 ADCY3 NLRP3 NCKAP1L ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MYO9B PRKACB-1 NOX1 PRKAR2A ARPC1B ARPC1A ADAM17 HSP90AB1 NT5E ACTG1 C3AR1 CD3G IL18 CYSLTR1 IL1A CYSLTR2 IL1B CDC42 GNAT3 P2RX4 SYK FGR HCK ADORA2B GNAZ GNAI3 CYBA FCGR3A;FCGR3B FYN FCGR1A C3-1 NCKIPSD CTSG HMOX1 PLCG2 ABI2 CALM3;CALM1 ABI1 LYN IL10 GNGT1 ACTR3-1 FURIN RELA AHCYL1 NFKB1 IL6 PRKX MAPK1 MAPK3 ENTPD1 DVL1 ENTPD5 DVL2 DVL3 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) HSPD1 SOD2 HSF1 DNAJA1-1 HTRA2 HSPE1 NRF1 FOXO3 CAT DEFA6;DEFA4;DEFA5 HSPA1A;HSPA1B HSPA9 LONP1 ATF5 ESR1 AKT1 SIRT3 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK RPA1 RPA2 RPA3 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC POLK REV1 RFC1 MAD2L2 REV3L PCNA UBA52 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis LBR MVD GGPS1 MVK IDI1 MSMO1 HMGCS1-1 FDFT1 IDI2 TM7SF2 NSDHL SQLE CYP51A1 ACAT2 EBP PMVK SREBF1 FDPS SREBF2 ARV1 HSD17B7 DHCR24 PLPP6 DHCR7 SC5D LSS CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PXMP2 ABCD2 ATAD1 PEX16 FIS1 PEX2 PEX3 ABCD3 PEX11B PEX12 ABCD1 GDAP1 PEX13 PEX14 PEX26 PXMP4 PEX19 ACBD5-1 SLC25A17 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions CNTNAP1 CNTN1 NFASC SDCBP ANK1 NRCAM DCX CELL DIVISION%REACTOME%R-HSA-68884.6 cell division STAG2 SMC1A NIPBL MAU2 KIF20A PDS5B PDS5A WAPL PLK1 SMC3 RAD21 KIF23 STAG1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) SOS1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IRS2 SHC2 RALGDS ATF2 RALB MAPK13 RIT1 SGK1-1 RIT2 REST SRF JUNB PLCG1 ADORA2A PPP2R1A MAPK7 MAP2K5 TCF12 RHOA YWHAB CRK FOS NTRK1 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 AP2S1 MAPKAPK2 DNAL4 SH3GL2 ID1 PPP2CB;PPP2CA EP300 PPP2R5D ATF1 ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MAPK14 MEF2C MAPK11 MAPKAPK3 ADCYAP1 ADCYAP1R1 MEF2D EGR1 STAT3 CDK5 CHD4 SH3GL3 ID4 IRS1 PIK3R2 PIK3CB HRAS PIK3R1 JUND NRAS TPH1 FRS2 PIK3CA KIDINS220 FOSB SHC1-1 NTRK2 CDK5R1 F3 RALA-1 NAB1 NAB2 LYL1 ARC VGF TRIB1 SHC3 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 MAP2K2;MAP2K1 RAP1A ID3 RAPGEF1 CDK5R2 ID2-1 MAPK1 BRAF MAPK3 CRKL MAPK12 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling CSNK2A1;CSNK2A3 WWTR1 SPOP CD4 PRKAB2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RPN2 CREBBP RPN1 PSMD12 PSMD11 PSMD14 PSMD13 LCK LEF1 PRKAB1 H2AC20 PSMA7 NFKB2 PSMD8 H2AB2;H2AB3;H2AB1 EZH2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 ASH2L PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 CSK PSMD1 MAGT1 JAK1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 NEK2 MIB2 BTRC NFE2L2 PSMC3 PSMA1 TEAD1 YWHAG PSMC4 PRKAG1 TEAD2 PSMC1 SKP1 TEAD3 CTNNB1 H2AJ TCF7 PRKAG3 TEAD4 TCF7L1 FOS SUZ12 H2BC5 UBA52 EPAS1 H2BC1 ERLIN1 ERLIN2 STAT1 CUL1 CDK4 ATF3 EP300 PDCD1LG2 VCP-1 RPS27A TUSC3 DERL2 H2AC4 RNF5 UBB;UBC OS9 RNF185 KMT2A KMT2C TMEM258 RBX1 STAT3 GSK3B OST4 DERL3 DERL1 DPY30 OSTC STT3A STT3B H2BC21 HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 IRF1 EED DDOST HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 H2AZ2;H2AZ1 HLA-DRA CD3G DAD1 ERLEC1 CD274 B3GNT3 HIF1A PRKAA1 CUL3 MYC JUND MYCN PTPN11 PTPN6 TNRC6C MOV10 CSNK2A2 TNRC6A-1 PDCD1 AGO4 PRKAA2 RBBP4 AGO2 RBBP5 BRD4 AGO3;AGO1 FOSB TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 RELA YAP1-1 TCF7L2 NFKB1 COPS5 H2AC14 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia ABCG5 ABCG8 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body TCN2 CD320 TCN1 LDLRAP1 LRP2 ABCD4 LMBRD1 ABCC1 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation LIG4 XRCC6 XRCC4 XRCC5 PSIP1 BANF1 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a MGAT2 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade ANO6 ANO5 SMPD1 SERPINE2 GPC1 SDC4 PROS1 GPC3 SERPINA5 SDC2 THBD GPC2 SDC3 GPC5 CD177 GPC4 GP1BB F2R GP1BA HSPG2 GPC6 F2 F3 F5 APP F7 PROCR ADAMTS13 F8 VWF F9 SERPING1 SERPINC1 KNG1 SERPIND1 AGRN PF4;PF4V1-1 F10 F12 F11 GP5 SDC1 GP9 PROC SERPINE1 KLKB1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules FLOT2 RTN3 DLG3 DLG4 FLOT1 GRIA1 GRIN2A GRIA3 LRFN3 GRIA4 LRFN2 GRIN2B PTPRF LRFN4 GRIN1 DLG1 LRFN1 PTPRD GRIN2C GRIN2D PTPRS ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes RPS14 RPS17 NUP133 RPS16 RPS19 RPS18 NUP50 GBP2;GBP3;GBP1 POM121;POM121C NUP54 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL NUP42 EIF1AY;EIF1AX NCK1 EIF3M EIF3K NUP43 EIF3L EIF3I EIF3J EIF3G SFN DUS2 RAE1 EIF3H RANBP2 EIF3E SNCA EIF3F EIF3D EIF3A DNAJC3-1 EIF3B PGGT1B FAAP24 RPS25 LOC105377022;FANCB RPS27 CASP1 FAAP100 RPS29 RPS20 CENPX NUP35 FANCM RPS21 FANCL RPS24 FANCA RPS23 PLCG1 FANCE FANCG IFIT1 FANCF IFIT3 JAK1 IFIT2 NUP37 TARBP2 PRKRA PPP2R1A MX1-1 FNTB;CHURC1-FNTB HSPA1L SKP1 CHUK UBA7 DDX58 ISG15 UBE2L6 HERC5 RPS27L ILF2 IKBKB RPS15A TRIM25 ARIH1 HSPA1A;HSPA1B IKBKG RPS3 IFIT5 UBA52 RPS2 NUP214 STAT1 CUL1 PPP2CB;PPP2CA OASL OAS1 ILF3 OAS3 FAU PIM1 PPP2R5A KPNA7 KPNA5 RPS27A KPNA3 PPP2R1B KPNA2 UBB;UBC RPS9 HSPA8 RPS7 RPS8 RPS5 RNASEL RPS6 ADAR EIF4G1 FLNB RPSA PPM1B CDK1 PTPN2 STAT3 EIF4A3 NPM1-2 MAP2K6 ACTB-1 FANCC KPNB1 NEDD4 UBE2I MAVS HSPA2 UBE2N PIN1 RPS4X SUMO1 RPS3A KPNA4-1 ACTG1 IRF3 GBP7;GBP4 TP53 BECN1 FNTA EIF4A2 EIF4A1 CENPS-CORT;CORT;CENPS FLNA USP18;USP41 NUP107 NUP188 EIF4E2 PDE12 KPNA1 EIF2S2 EIF4E EIF2S3;EIF2S3B NUP210 DHX9 EIF2S1 NUP93 NUP205 EIF4G3 EIF4G2 ABCE1 AAAS EIF4E3 NUP160 NUP85 TPR NUP88 NUP155 FURIN NUP153 UBE2E1 SPHK1 EIF2AK2 NUP62 MAPK3 GBP5-1 NDC1 RPS15 SEC13 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha RBX1 HIF3A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HIF1A ADRM1 PSMC2-1 VHL PSMA2-1 PSMA5 CUL2 LIMD1 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 UBE2D3-1 PSMC3 PSMA1 PSMC4 PSMC1 AJUBA UBE2D3;UBE2D2 UBA52 EPAS1 UBE2D1 EGLN1 EGLN3 EGLN2 RPS27A WTIP UBB;UBC ELOC-1 ELOB DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC MMACHC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation NCBP1 EAF1 EAF2 CTR9 RTF1 CDK7 CTDP1 PAF1 MNAT1 POLR2A SUPT6H POLR2B POLR2C POLR2D AFF4 POLR2G POLR2I MLLT1 MLLT3 IWS1 SSRP1 NCBP2-1 TCEA1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 CDC73 SUPT16H POLR2E LEO1 POLR2F GTF2F1 POLR2H GTF2F2 POLR2L ERCC3 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 ELL ELOC-1 WDR61 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN TNKS TNKS2 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation NBEA ADCY9 PRKAR2B PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKACA-1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events PRKAR1B PRKAR1A GRIN2A RASGRF2 GRIN2B GRIN1 ADCY1 ADCY8 PRKAB2 PRKACB-1 PRKAR2A CAMK4 PRKAB1 PDPK1 CAMK1 SRC CAMKK1 GRIA1 CAMKK2 DLG1 HRAS PRKAA1 CAMK2B CAMK2D CAMK2A PRKAG2 NRAS PRKACA-1 CAMK2G PRKAA2 PRKAG1 GRIA2 RAC1 PRKAG3 NRG1 CALM3;CALM1 RPS6KA6 ACTN2 GRIN2C GRIN2D DLG2 DLG3 DLG4 RASGRF1 PRKAR2B GIT1 NRGN RPS6KA3 RPS6KA2 NEFL KPNA2 RPS6KA1 LRRC7 PRKX MAPK1 MAPK3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint CDK1 BLM CCNA2-1 CCNA1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 UBE2N H2BC21 RAD9B KAT5 CHEK2 CHEK1 SFN RAD9A HUS1 YWHAQ EXO1 YWHAH TOPBP1 DNA2 RHNO1 RFC5 RFC3 RFC4 RFC2 TP53 YWHAE ATRIP WEE1 UBE2V2 BARD1 RBBP8 RAD17 ATM TP53BP1 RAD50 ATR YWHAG BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 BABAM1 BABAM2 RMI2 UIMC1 YWHAB RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 WRN H2BC1 YWHAZ RPA1 HERC2 RPA2 CCNB1 NSD2 RPA3 RAD1 BRIP1 MRE11 NBN CDC25C DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 B4GAT1 LARGE1 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway ADI1 MRI1 GOT1-1 MTAP ENOPH1 APIP THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis CD28 ARF1 RAC1 B2M ATP6V1H HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD4 ELMO1 AP2A1 PAK2 AP2B1 AP2A2 AP1G1 AP1S2 LCK CD8B;CD8B2 AP1S1 AP2S1 AP1S3 AP1B1 DOCK2 HCK PACS1 AP1M2 FYN AP1M1 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ABL1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MDC1 UBE2N KDM4A H2BC21 KDM4B EYA1 KAT5 CHEK2 SMARCA5 SUMO1 PHF6 TP53 UBE2V2 BARD1 ATM TP53BP1 RAD50 BAZ1B BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 BABAM1 BABAM2 UIMC1 ABRAXAS1 UBXN1 RNF8 BRCC3 APBB1 H2BC15;H2BC3;H2BC11;H2BC12 EYA2 H2BC5 EYA3 EYA4 BAP1 UBA52 PPP5C H2BC1 HERC2 NSD2 RPS27A UBB;UBC MRE11 NBN MAPK8 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) OPN1MW3;OPN1MW2;OPN1MW;OPN1LW AWAT2 OPN1SW DHRS3 RLBP1 RBP3 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm OSR1 PAX2 BMP4 FOXC2 FOXC1 PAX8 LHX1 FGF2 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy TBK1 ULK1 UBE2V1 UBE2D3-1 CSNK2A2 PRKN CSNK2A1;CSNK2A3 OPTN-1 CSNK2B MAP1LC3B2;MAP1LC3B-1 SQSTM1 UBE2N UBE2D3;UBE2D2 UBA52 TOMM20 TOMM22 VDAC2-1 MAP1LC3A RPS27A FUNDC1 MFN1 ATG9A MFN2 ATG12-1 UBB;UBC VDAC3 TOMM40 PINK1 ATG5 MTERF3 TOMM7 VDAC1 TOMM70 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling PLA2G4A GNA13 AKT2 AKT3 MGLL TAS2R3-1 PDE3B TAS2R16 DRD1 DRD3 DRD4 DRD5 POMC TAS2R40 TAS2R41 APP TAS2R39 ADORA2A EGFR ADORA3 ADORA1 PRKACA-1 PPP2R1A PRKCE TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PRKAR2B PRH1-TAS2R14;TAS2R14-3 RPS6KA3 KPNA2 RPS6KA2 RPS6KA1 TIAM2 PDE1B PDE1A PDE2A PDE11A PDE10A LHB TAS2R7 TAS2R8 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 TAS2R1 TAS2R4 PDPK1 CAMKK1 CAMKK2 C3AR1 TAS1R2 TAS1R1 CDC42 TAS1R3 CALM3;CALM1 MMP3 GNAL GNGT1 NBEA RGS9 ITGA5 RGS6 RGS7 GLP1R SST GNA14 GNG10 RAMP2 GABBR2 GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 ADM IAPP GNB4 CHRM2 GNB3 CHRM4 ADRB1 ADRB2 GNB5 HTR4 RGS11 HTR6 HTR7 HRH2 CALCRL HRH4 HTR1E TAAR8 TAAR9 MCHR1 HTR1F TAAR6 HTR1D TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 SCT RXFP4 RXFP1 MAPK7 RXFP2 RXFP3 GPR176 AGTR2 FPR1 SSTR3 GHRHR GALR3 GALR2 GALR1 NPBWR1 RHOA NPBWR2 GPR15 GPR183 PNOC MC4R GPR18 GPR27 EDNRB GPR25 HBEGF RHO GPR20 PTH1R EDN1 EDN3 GPR37 GPR32 PTH2R RGR MC3R GPR45 MC1R MC5R NPFFR2 GPR150 NPFFR1 P2RY12 NPFF HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR QRFP GPR55 HCRTR2 SCTR HCRTR1 ADM2 MTNR1A MTNR1B GPR83 GPR84 CALCB;CALCA RLN3 INSL3 INSL5 P2RY4 ADCYAP1 APLN ADCYAP1R1 VIPR1 VIPR2 RRH PTGDR GPR37L1 TAS2R42 ADRA2B GIPR CRHR1 PENK PPY CDK5 PPP1R1B CRH PDE3A PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB RAMP3 PTH PTGER2 PTGER3 NPW RLN2;RLN1 GHRH HCAR1 HCAR2;HCAR3 RAMP1 NPY2R NPY RGS8 CAMK4 PDE8B PDE8A NPY1R PCP2 APLNR SUCNR1 GRK3 CALCR GRK6 PIK3CG OPN3 OXTR PDE4D-1 RGSL1 GRPR OPN5 TRPC7 EDNRA PYY PROK2 GPSM1 PROK1 GPSM2 TRPC6 UTS2R PRKCH TRPC3 TRHR GRM3 OPRM1 UTS2B HEBP1 CAMK2B AGTR1 GRM2 CAMK2D PTGFR CAMK2A LPAR1 GRM7 LPAR2 GRM6 CXCL12 LPAR3 GPER1 FPR2 LPAR4 GRM8 CAMK2G NTSR1 PDE4A NTSR2 GPSM3 GPR17 PTGIR NMB NPY5R XCR1 PDE4C OPRK1 XCL1;XCL2 GLP2R NMBR SSTR1 LPAR5 SSTR2 LPAR6 NMS SSTR4 NMU SSTR5 GNRH1 RGS14 MLN OPRL1 BRS3 PTHLH GPRC6A CNR2 GPR132 CNR1 CCKAR RGS20 GNRHR S1PR3 PRKCQ FFAR4 RGS22 FFAR2 S1PR2 GAST S1PR5 GPR39 RASGRP2 S1PR4 EDN2 RASGRP1 RGS10 ANXA1 RGS12 TACR2 PDE7B TACR3 TACR1 VIP CCKBR PDE7A NPSR1 GRP F2R TIAM1 PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 DGKG DGKE CHRM1 AHCYL1 DGKD CCR2 GPR68 DGKB GPR65 DGKA PRKX MAPK1 CHRM5 PMCH MAPK3 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ SOS1 LTB4R2 DGKQ DGKK DGKI DGKH PIK3R3 ABHD6 PIK3R6 NTS PIK3R5 MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGS19 RGS13 CALCA RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK KISS1 FFAR3;GPR42 PDE1C GRK2 GIP ROCK1 GCGR PPP1CA PLEKHG5 AKT1 PRKCD PRKCA C5AR1 C5 TRIO ITSN1 PREX1 PRKCB NGEF GNAS-1 ADCY9 PRKAR1B PRKAR1A ABR ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A ADRA1D ADRA1B ADRA1A TBXA2R GNA12 FSHB ARHGEF33 ARHGEF37 ARHGEF38 CRHR2 CYSLTR1 CYSLTR2 GNAT3 ADORA2B GNAZ HRAS GNAI3 FGD1 FGD2 FGD3 OPN1SW FGD4 NRAS C3-1 SAA2;SAA1 MCF2 MC2R ARRB1 PLCB3 PLCB4 PLCB1 PLCB2 CCR5 AGT CHRM3 PLXNB1 AVPR2 RASGRF2 CXCR4 GNAT2 PLEKHG2 PRKCG ITPR1 ITPR2 ITPR3 PPP3R1 SOS2 ROCK2 SRC PSAP ARRB2 PPP3CA PPP3CB GNAI1 GNAI2 GCG CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCR9 CXCL5;CXCL6 CCR8 CCR7 BTK CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 KALRN CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 CCR10 CCL16 CCR1 NET1 CCL25 CCL21 CCL20 PPBP CXCL10 CXCL11 AKAP13 CCL28 CCL27 ACKR3-2 PPP2CB;PPP2CA VAV3 PPP2R5D LHCGR PPP2R1B FSHR GPHA2 RHOC TSHR GPHB5 VAV1 VAV2 RHOB ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 GNAT1 ITGB1 ARHGEF6 PAK1 PDYN FFAR1 PIK3R2 ARHGEF40 PIK3R1 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 PIK3CA CGA ECT2 ARHGEF39 CX3CR1 ARHGEF10L MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 AVPR1B ARHGEF19 ARHGEF18 AVPR1A AVP TSHB LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis LALBA B4GALT1 SLC2A1 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway MAN2A1 MGAT2 LHB MAN2A2 FUT6;FUT5;FUT3 CHST8 CHST10 CGA FUT8 FUCA1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation SLC35D1 UGT1A1;UGT1A6 ABHD10 SLC35D2 UGP2 UGT2A1 UGDH UXS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation AKT2 AKT3 CSNK2A1;CSNK2A3 BMI1 RING1 ATF2 HDAC5 PSMD12 RNF2 PSMD11 PSMD14 HDAC7 PSMD13 REST CBX8 RRAGA PSMA7 RRAGC CBX6 PSMD8 RRAGB PHC2 PHC1 RRAGD EZH2 PSMB6 CBX4 PSMB7 PSMD6 CBX2 PSMB4 PSMD7 PSMB5 PHC3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 RPTOR MBD3 SUZ12 AKT1 UBA52 KDM1A GATAD2B GATAD2A RPS27A LAMTOR2 LAMTOR1 UBB;UBC LAMTOR4 LAMTOR3 LAMTOR5 PREX2 USP7 EGR1 SNAI1 SNAI2 SLC38A9 RCOR1 ATN1 SALL4 MAF1 MECOM NEDD4 RHEB CHD4 CHD3 TRIM27 USP13 TNKS TNKS2 RNF146 FRK OTUD3 EED PTEN MLST8 PPARG TP53 NR2E1 HDAC2 HDAC3 HDAC1 PML MTOR TNRC6C MOV10 MTA1 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 WWP2 TNRC6B CSNK2B RBBP7 MTA2 MTA3 MKRN1 MAPK1 MAPK3 STUB1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation TTN-1 CAP1 VEGFA CD109 RAB27B APP TLN1 ISLR HABP4 CHID1 PSAP GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 SERPINE1 LY6G6F;LY6G6F-LY6G6D ALB EGF ENDOD1 APOH PECAM1 SPARC VTI1B MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 PCDH7 CTSW TIMP3 HGF ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD AHSG LHFPL2 PCYOX1L FAM3C ACTN1 LEFTY2;LEFTY1 APLP2 TMX3 APOA1 SELENOP SCG3 PFN1 HSPA5 RARRES2 CYRIB SCCPDH LAMP2 LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CDC37L1 TUBA4A BRPF3-1 STXBP2 PPBP ITGA2B VWF ABCC4 PF4;PF4V1-1 TGFB2 TGFB3 MMRN1 CYB5R1 TF PDGFB APOOL SELP ORM2;ORM1 QSOX1 CD63 ACTN4 VCL IGF2 A1BG FN1 IGF1 SERPINA3 PPIA A2M SERPINF2 ALDOA HRG THBS1 FLNA CFD TIMP1 SERPINA1 TGFB1 CALM3;CALM1 ACTN2 ITGB3 PROS1 F13A1 CFL1 FGB FGA FGG F5 PLG F8 SOD1 SERPING1 CLU KNG1 CD9 GAS6 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production IRF7 NFKB1 MYD88 RELA NFKB2 DHX36 DHX9 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus LIG4 XRCC6 XRCC4 XRCC5 PSIP1 BANF1 KPNA1 PPIA NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling NTF3 NTRK3 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK SOS1 PIK3CA IRS1 GRB2 PIK3R2 LTK PIK3CB TNK2 PIK3R1 ALKAL2 ALKAL1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM SLC34A2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy HDAC6 HSP90AB1 IFT88 CETN1 EEF1A1 PLIN3 HSP90AA1 HBD;HBB RNASE1 RPS27A CFTR GFAP PCNT LAMP2 ARL13B UBB;UBC HSPA8 PLIN2 PARK7 UBA52 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 KCNN1 KCNN3 KCNN2 KCNN4 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes MAFK NFE2L2 ABCG2 ABCF2-H2BE1;ABCF2 CREBBP ABCC3 EP300 ABCC1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K PIK3CA IRS1 NTF3 PIK3R1 SRC NTRK3 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling MCL1 S1PR1 VIM FOXO1-1 TNF CEBPD IL4R MUC1 VEGFA IL13 VCAM1 LCN2 IRF4 ITGB2 SOCS1 POMC STAT6 POU2F1 OSM BATF IL4 JUNB CD36 JAK1 HGF TYK2 CXCL8 CDKN1A HSP90AA1 CCL13;CCL2 CCL11 IL13RA2 IL13RA1 FOS SOX2 AKT1 CCL22 SOCS3 LIF ITGAX STAT1 LBP IL17F PIM1 ITGAM IL17A HSPA8 TNFRSF1B ZEB1 HSP90B1 NANOG;NANOGP8 RHOU FSCN1 MAOA ITGB1 STAT3 BCL2 GATA3 BCL2L1 FGF2 FCER2 COL1A2 OPRD1 BCL6 JAK2 RORA IL23R IL23A FN1 IL18 IL1A IL1B TP53 PIK3R1 BIRC5 RORC IL2RG HIF1A OPRM1 SOCS5 MYC JAK3 NDN SAA2;SAA1 HMOX1 TIMP1 FASLG FOXO3 TGFB1 CCND1 ALOX15 MMP1 NOS2 MMP2 MMP3 MMP9 ALOX5 F13A1 ANXA1 IL12B IL12A IL6R IL10 LAMA5 PTGS2-2 IL6 ICAM1 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS ALG14 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CTNS SLC15A1 SLC15A3 SLC15A4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions LIMS4;LIMS1 FLNA ITGB1 ARHGEF6 ACTN1 VASP FLNC LIMS2 ILK PARVA TESK1 FBLIM1 RSU1 FERMT2 PARVB PXN ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 PDZD11 ATP10A ATP1A1 ATP2C2 ATP2C1 ATP9B ATP9A ATP1B3-1 ATP13A1 FXYD2;FXYD6-FXYD2 ATP13A4 ATP13A5 ATP13A2 CAMK2B CAMK2D ATP8A2 CAMK2A ATP8A1 ATP12A CAMK2G ATP11C ATP11B ATP2B4 ATP2A3 ATP1B2 ATP11A ATP2B3 ATP2A2 ATP1B1 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP7A ATP4B ATP4A FXYD4 FXYD3 FXYD1 FXYD6 CUTC ATP7B REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation FOXO1-1 TXN SIRT1 KAT2B CREBBP FOXO4 EP300 FOXO3 TXNIP SIRT3 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors FOXO1-1 SFN YWHAZ YWHAQ YWHAB YWHAG AKT2 AKT3 FOXO4 FOXO3 AKT1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA TBK1 TRIM56 STING1 TRIM21 IRF3 RPS27A UBB;UBC NLRP4 TREX1 DDX41 TRIM32 ZBP1 UBA52 DTX4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor GNB3 AAMP GNGT1 TBXA2R GNA13 GNB5 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 GNB4 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 CBL UBB;UBC DOK1 PTK6 AKT1 RPS27A UBA52 ARAP1 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR FLT1 NRP2 NRP1 KDR DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification RPUSD4 RPUSD3 TRUB2 MTERF3 MTPAP RCC1L NGRN TRMT61B SLIRP LRPPRC FASTKD2 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia IVD SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis DLD OGDH MRPS36 DLST HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones KDM4D KDM1A KDM6A KDM4C-1 JMJD6 RIOX2 KDM5A KDM1B KDM5B KDM5C PHF2 KDM6B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM7A KDM3A PHF8 KDM3B KDM2A KDM2B KDM4A KDM4B ARID5B TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 PIK3R4 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B EEA1 RPS6KA5 TASL RPS6KA2 IRF5 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 RBSN TRAF6 IRF7 TP53 PIK3C3 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SLC15A4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors ADCYAP1R1 SCT VIPR1 VIPR2 GNG10 GNAS-1 GIPR GNG2 GLP2R GNG5 GNG4 GHRHR GNG8 GNG13 GNB2 GNB1 VIP GNB4 GNB3 GNGT1 GHRH GNB5 GIP GLP1R SCTR GCGR GCG ADCYAP1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 BUB1B CDC23 CDC20 CDC26 CDC27 ANAPC7 BUB3 UBE2C MAD2L1 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis UACA GZMH;GZMB-1 AKT2 AKT3 VIM SATB1 PSMD12 PSMD11 PSMD14 SFN TP63 PSMD13 DSG2 PPP3R1 PSMA7 PSMD8 GSDME PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 TP53BP2 YWHAE ADRM1 ROCK1 PSMC2-1 E2F1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 PSMA3 PSMC6 DSP PSMA4 TP73 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 BIRC2 CTNNB1 PLEC OCLN-1 YWHAB DSG1 PTK2 AKT1 UBA52 PRKCD YWHAZ TJP1 C1QBP DAPK1-1 DAPK2 DAPK3 PKP1 SPTAN1 APPL1 DSG3 CYCS-1 RPS27A APC ADD1 UBB;UBC CLSPN AVEN GSDMD DBNL GSN DIABLO-1 STK24 CASP9 STK26 CASP7 GAS2 BAK1 MAPT MAPK8 BCL2L11 BAD STAT3 BCL2 PMAIP1 BMF BID BBC3 BCL2L1 UNC5A PPP3CC DCC UNC5B CDH1 BCAP31 KPNB1 DNM1L BMX TJP2 PPP1R13B YWHAQ YWHAH CASP6 APIP OPA1 APAF1 TP53 FNTA CASP3 BAX TICAM2 TRADD LY96 FASLG TRAF2 TICAM1 KPNA1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CD14 FADD HMGB1-1 TLR4 PRKCQ LMNB1 DFFB DFFA HMGB2 PAK2 H1-0 H1-3 H1-2 H1-5 H1-4 ACIN1 MAGED1 NMT1 CDKN2A ARHGAP10 MAPK1 MAPK3 OMA1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis MOCS2 GPHN MOCS3 MOCOS FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes HDAC1 FOXO4 FOXO3 ATXN3 ABCA6 FOXO1-1 INS;INS-IGF2 FBXO32 PPARGC1A G6PC1 NR3C1 SIN3A SIRT3 POMC SREBF1 SMAD2;SMAD3 TRIM63 NPY GCK SOD2 IGFBP1 AGRP SMAD4 CAT RETN PCK1 PLXNA4 HDAC2 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development WNT9B HNF1B DLL1 POU3F3 HNF4A LFNG WNT4 IRX1 WT1 IRX2 LHX1 JAG1 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria TP53 TFDP1 TP63 PPP1R13B TFDP2 TP73 TP53BP2 BBC3 E2F1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas LAMA5 LAMA3 LAMA2 LAMA4 FN1 LAMB3 LAMB2 LAMB1 FGF2 FGF7 VTN LAMA1 EGF FGF10 LAMC3 LAMC2 LAMC1 FGF4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle UNC13B RAB3A SYT1 VAMP2 STX1A CPLX1 SNAP25 RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 TSPOAP1 SLC5A7 CHAT SLC18A3 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid RARG PDK4 FABP5 ADH4 CYP26B1 CYP26A1 ADH1C;ADH1B;ADH1A RARB PDHB RXRG CRABP2 CRABP1 DHRS3 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH14 DLD RDH13 PPARD ALDH8A1 RXRA DLAT RARA RDH11 PDK3 PDK2 PDK1 PDHX RDH5 PDHA1 RXRB ALDH1A1 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis DHRS7B FAR1 AWAT2 FAR2 AGPS GNPAT AWAT1 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 RAD51AP1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 PALB2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling SPRED2 FGF23 FGF22 FGF3 SPRED1 FGF10 FGFRL1 FGF4 FGF2 FGF18 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 MPP5 TJP1 PATJ CRB3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling GAB1 PIK3CA NRG1 NRG2 EREG BTC EGF NRG3 ERBB2 NRG4 EGFR PIK3R1 HBEGF SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling SOS1 PRKCD PRKCA PTPN12 PRKCE NRG1 NRG2 EREG BTC EGF SHC1-1 NRG3 ERBB2 NRG4 EGFR HRAS HBEGF NRAS HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones MORF4L1-2 SAP130 SUPT7L KAT6A KAT6B MORF4L2 MBIP HAT1 KAT8 ENY2 TAF5L ATXN7 DR1 EP400 DMAP1 BRPF1 MRGBP YEATS2 ACTB-1 HCFC1 TADA3 TADA1 TAF9 VPS72 MSL2 OGT-1 H2BC18 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MSL1 CREBBP ATF2 H2BC21 KAT5 USP22 MSL3-1 WDR5 TADA2A ZZZ3 CLOCK TAF12 H2AC20 TAF10 PHF20 MEAF6 SGF29 NCOA1 NCOA2 ACTL6A TRRAP EPC1 SUPT20H KAT2B KAT2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ING5 RBBP7 BRD1 TADA2B PAX3 H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 ING4 BRPF3-1 H2BC5 ING3 MCRS1 KANSL2 H2BC1 KANSL3 SUPT3H TAF6L BRD8 ELP1 ELP2 EP300 ELP3 ELP4 ELP5 H2AC16;H2AC11 ELP6 H2AC4 JADE1 YEATS4 JADE3 JADE2 RUVBL2 RUVBL1 H2AC14 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 DHH IHH UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 VCP-1 SHH PSMB4 RPS27A PSMD7 SYVN1 DERL2 ERLEC1 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 OS9 PSMD3 PSMB1 HHAT PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 TP63 PPP1R13B TP73 TP53BP2 TMEM219 IGFBP3 FAS INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis UACA BCL2L11 GZMH;GZMB-1 BAD STAT3 BCL2 PMAIP1 AKT2 BMF AKT3 BID BBC3 BCL2L1 PPP3CC SFN TP63 PPP1R13B YWHAQ PPP3R1 YWHAH GSDME APIP APAF1 TP53 TFDP1 TFDP2 TP53BP2 YWHAE E2F1 XIAP CASP3 BAX TP73 YWHAG CASP8 YWHAB AKT1 YWHAZ C1QBP CYCS-1 NMT1 CDKN2A AVEN GSDMD DIABLO-1 CASP9 MAPK1 CASP7 BAK1 MAPK3 MAPK8 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 UBE2V1 IRAK1 IRAK2 TRAF6 MAP3K7 MAP2K4 IKBKG NOD1 NOD2 MAPK9 MAPK8 UBE2N TAB3 MAP2K7 RIPK2 MAPK10 TAB2 TAB1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 SLC38A1 GLUL RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration AKT2 ITGA5 MMP13 AKT3 AKT1 CBFB ITGBL1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies BDH2 BDH1 HMGCS2 HMGCLL1 HMGCL AACS ACSS3 ACAT1 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR EREG BTC EGF AREG TGFA EGFR HBEGF EPGN RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SREBF1 HELZ2 RXRA MED1 NRIP1 CARM1 CHD9 PPARA EP300 NR1D1 NCOR1 CPT1A TBL1XR1 RORC PPARGC1A NCOA1 NCOA2 CREBBP TGS1 RORA NCOA6 SMARCD3 HDAC3 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain F8 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism MTR-1 MMADHC MTRR MMAA ABCD4 MMAB MMUT CUBN TCN2 CD320 CBLIF LMBRD1 MMACHC AMN MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal MGMT ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) EPO PLCG1 EPOR IRS2 PLCG2 JAK2 LYN SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP BMPR1B BMPR1A ACVRL1 BMP10 UBE2D3-1 BMPR2 CHRDL1 AMH NOG TGFBR3 GREM2 FSTL1 ACVR2B ACVR2A INHA UBE2D1 BMP2 AMHR2 CER1 SKI SMAD1 SMAD4 ZFYVE16 SMURF2 SMURF1 SMAD6 SMAD7 GDF2 SMAD9 INHBA SMAD5 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUP133 DYNC1LI1 DYNC1LI2 KIF18A BUB1 NDC80 RANGAP1 CLASP2 CENPN-2 MIS12-1 BUB1B CDCA8 CDC20 SKA1 PPP1CC SKA2 BUB3 MAD2L1 DYNC1I1 SPDL1 NUP43 B9D2 SPC24 SPC25 RANBP2 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP NSL1 RPS27 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 NUP37 SGO2 AURKB CENPS-CORT;CORT;CENPS MAPRE1-1 PPP2R1A CENPT NUP107 CENPU KNL1 ZW10 CENPF CENPH CENPI TAOK1 DSN1 CENPK CENPL CKAP5 CENPM RCC2 ZWINT XPO1 CENPO NUP160 CENPP AHCTF1 PAFAH1B1 NUP85 CENPQ DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E CLIP1 MAD1L1 DYNC1H1 NDE1 ITGB3BP PLK1 SEC13 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism DLD MCCC2 ECHS1 IVD MCCC1 BCKDHA PPM1K DBT BCKDHB BCKDK HIBCH ACAT1 AUH RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy ATG12-1 MAP1LC3B2;MAP1LC3B-1 ULK1 ATG5 CSNK2A2 CSNK2A1;CSNK2A3 MAP1LC3A FUNDC1 CSNK2B SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair ACD TINF2 TERF2 POT1 TERF2IP TERF1-1 PARG PNKP POLB MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 APEX1 ADPRS POLD1 H2BC21 PARP1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 MPG OGG1 H2AJ TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 POLE RFC1 PARP2 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 H2BC5 PCNA H2BC1 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 XRCC1 POLE4 FEN1 H2AC4 POLE2 POLE3 H2AC14 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction HCK LCK ELMO1 FYN RAC1 DOCK2 PAK2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones FKBP14 CXXC1 MYDGF TATDN2 PDIA6 YIF1A PDIA5 HDGF KLHDC3 ERN1 SRPRA HSPA5 SEC31A GOSR2 SHC1-1 TSPYL2 DDX11 ATP6V0D1 ZBTB17 SSR1 DNAJB11 GSK3A TLN1 DNAJC3-1 EXTL1 ACADVL DCTN1 WFS1 PPP2R5B EXTL2 TPP1 HYOU1 SYVN1 LMNA EDEM1-1 ADD1 WIPI1 CTDSP2 EXTL3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARFGAP1 DNAJB9 GFPT1 SRPRB-1 CUL7 JMJD7-PLA2G4B;PLA2G4B PREB KDELR3 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules ABCG5 ADD3 NR1H3 ABCC5 STOM ABCC6 ABCC9 SLC4A7 SLC26A11 RAB11FIP2 MYO5B SLC12A2 SAR1B SLC12A4 SLC12A5 SLC12A7 SLC26A2 SLC6A4 SLC26A1 RHCG RHBG VDAC2-1 VDAC3 MAGT1 SLC2A8 PRKACA-1 ANO8 ANO9 ANO6 ANO4 ANO5 ANO2 APOA2 APOA1 SKP1 ANO3 APOA4 ANO1 APOA5 PCSK6 APOC3 MIP ANO10 AQP8 AQP10 AQP9 AQP6 UBA52 AQP11 AQP4 APOC2 AQP5 SLC35B3 AQP2 AQP3 SLC35B2 LOC100509620;LOC112267859;AQP7 CUL1 AQP1 PRKAR2B VCP-1 RPS27A SLC22A3 SLC22A8 TUSC3 UBB;UBC SLC22A4 CYB5R2 SLC22A5 CYB5R1 SLC35D1 CYB5R4 CYB5RL SLC35D2 SLC16A8 SLC16A3 CREB3L3 ABCA6 SLC14A1 SLC14A2 SLC47A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC25A26 BSG SLC22A15 SLC22A16 HBD;HBB AKAP1 A2M SLC8A3 ATP2B4 ATP2A3 EIF2S2 ATP2B3 EIF2S3;EIF2S3B ATP2A2 ATP2B2 EIF2S1 ATP2A1 ATP2B1 SRI CALM3;CALM1 ATP6V1H SLC8A1 SLC8A2 GNGT1 FURIN LIPG LCAT APOBR SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC7A1 SLC1A7 SLC7A3 SLC25A29 SLC38A3 ARL2 SLC38A2 SLC38A5 SLC38A4 SLC36A1 GNG10 SLC6A19 SLC38A1 GNG2 SLC36A2 GNG5 SLC6A15 GNG4 SLC6A14 SLC16A10 GNG8 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GNG13 GNB2 SLC5A8 GNB1 SGK1-1 GNB4 GNB3 GNB5 FBXL5 ABCB7 ABCB4 SLC5A5 SEL1L GPIHBP1 ABCA1 SLC24A5 ARF1 ANGPTL4 WWP1 SLC16A7 RAB11A EMB ABCD2 ABCC10 ABCC4 PEX3 ABCG4 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ABCA5 ADD1 ABCA9 ABCA7 ABCA8 STEAP3 ABCB10 LETM1 LPL SLC24A2 SLC9A1 SLC24A3 SLC8B1 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLCO1A2 ABCD1 TRPM1 TRPM2 TRPM7 TRPM8 ABCB1 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 SLC2A9 TRPC3 TRPA1 TRPC4 SLC25A18 CAMK2B TRPC1 CAMK2D TRPV2 CAMK2A TRPV3 SLC25A10 TRPV1 MCOLN1 SLC25A4 TRPC4AP SLC25A11 MCOLN2 MRS2 CAMK2G SLC66A1 TRPV6 TRPV4 ADD2 CAND1 NIPAL4 TRPV5 PIP-1 ANKH NIPAL1 NIPAL2 NIPAL3 LRRC8C LRRC8D PCSK5 LMF2 LRRC8A LMF1 LRRC8B LIPC LRRC8E ANGPTL8 DMTN ANGPTL3 MMGT1 NIPA1 FGF21 CTNS NIPA2 AZGP1 SLC25A22 SLC2A4 ATP7A SLC11A1 PCSK9 LSR LIPA NCEH1 NPC1-1 SOAT1 SOAT2 NPC2 SLC34A2 SLC34A1 APOC1 MTTP APOC4 P4HB APOB PDZD11 LCN2 PSMD12 PSMD11 PSMD14 PSMD13 SLC35B4 LCN15 LCN12 PSMA7 APOD SLC35A2 PSMD8 SLC35A3 SLC33A1 PSMB6 SLC35C1 ARL2BP PSMB7 PSMD6 LCN1 APOF PSMB4 SLC27A6 PSMD7 SLC29A4 PSMB5 SLC28A2 PSMB2 SLC25A5 SLC29A1 PSMB3 PSMD2 SLC28A1 PSMD3 SLC29A3 PSMB1 SLC27A4 PSMD1 SLC29A2 SLC17A8 SLC28A3 SLC25A6 ADRM1 PSMC2-1 ATP8A2 PSMA2-1 PSMA5 ATP8A1 ATP12A SLC30A3 SEM1 PSMA6 BEST2 SLC30A2 SLC39A10 PSMC5 BEST3 PSMA3 SLC9C2 SLC30A1 SLC39A14 PSMC6 BEST1 PSMA4 BEST4 SLC39A6 SLC39A5 ATP6V1E1 PSMC3 SLC39A8 ATP6V1E2 PLEKHA8 PSMA1 SLC39A7 ATP6V1G1 PSMC4 SLC39A2 ATP6V1G2 PSMC1 SLC39A1 ATP11C SLC39A3 ATP11B ATP1B2 SLC5A6 ATP11A ATP1B1 SLC9B1 SLC9B2 SCNN1G CLCA4-1 SLC7A5 SCNN1D SCNN1B SCNN1A SLC5A7 RAF1 ATP6V0D1 SLC10A6 ATP6V0D2 ATP6V1A TTYH3 TTYH2 WNK4 NALCN ASIC4 SLC9A2 ASIC5 SLC9A3 CLCA2 SLC9A4 ATP6V0A2 SLC9A5 CLCA1 SLC9A6 ATP6V0A4 SLC9A7 ASIC2 SLC9A8 ATP6V1D SLC9A9 ASIC3 ATP6V1C1 ATP6V1F ATP6V0A1 ASIC1 ATP6V1C2 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B TFRC ATP4A DERL2 FXYD4 FXYD3 RNF5 WNK1 FXYD1 OS9 SLC27A1 WNK3 FXYD6 SLC25A1 SLC22A6 CUTC SLC5A12 RYR1 STEAP4 SLCO2B1 RNF185 RYR2 HFE SLC16A2 TCIRG1 SLC22A17 SLC13A5 RYR3 GLRX3 TFR2 UNC80 SLC13A2 IREB2 SLC13A3 CLCNKA;CLCNKB ATP7B SLCO1C1 FTMT SLCO4A1 CYBRD1 CLIC2 TF ATP6V0B TSC22D3 TRDN ASPH ATP6V1B2 ATP6V0C SLC26A7 ATP6V1B1 SLC26A9 GNAS-1 STOML3 SLC26A6 ATP10D ADCY9 ATP1A4 ATP1A3 CYGB PRKAR1B ATP10B PRKAR1A ATP1A2 ATP10A ATP1A1 MBTPS1 ATP2C2 ADCY4 ATP2C1 ADCY3 CLCN3 CLCN2 MBTPS2 ADCY2 CLCN1 ADCY1 BSND ADCY8 SGK3;C8orf44-SGK3 ADCY7 ATP6V1G3 ADCY6 ATP9B ADCY5 ATP9A SLC5A9 PRKACB-1 ATP1B3-1 SLC30A10 ATP13A1 SLC5A4 FXYD2;FXYD6-FXYD2 PRKAR2A SLC2A11 TPCN2 SLC2A12 TPCN1 SLC13A1 CLCN7 SLC13A4 CLCN6 SLC5A10 CLCN5 ACO1 GLTP SLC30A8 CLCN4 ATP6V0E2;ATP6V0E1 SLC45A3 SLC30A5 OSTM1 MFSD4B-2 SLC20A1 FKBP1B SLC35A1 SLC31A1 ATP13A4 ESYT3 ATP13A5 ESYT2 ATP13A2 UNC79 SLC41A2 SLC41A1 SLC2A6 SLC2A7 CPTP CLN3 SLC50A1 CUBN SLCO4C1 SLC36A4 SLC6A7 PEX19 NEDD4L SLC2A13 SLC5A11 SLC5A3 SLC32A1 SLC6A13 FTH1 SLC6A1 LDLRAP1 MB NGB CES3 SLC4A1 SLC4A4 APOE FTL-1 SLC39A4 SLCO2A1 SLC26A4 SLC26A3 AVPR2 VLDLR SLC22A12 SLC22A18 ALB AMN SLC40A1 SLC22A2 HEPH SLC22A1 SLC6A9 SLC17A6 SLC17A7 KCNJ11 CFTR ABCB6 SLC5A2 CLTC SLC46A1 ABCA3 CLTA ABCA4 AP2A1 AP2B1 ERLIN1 ERLIN2 AP2A2 CP AP2S1 SLC16A1 SLC6A12 SLC6A11 CETP STOML2 VDAC1 MCUB SPG7 PHB ABCG1 MAIP1 PHB2 PARL AFG3L2 SMDT1 YME1L1 PMPCB SLC12A3 MICU3 PMPCA SLC12A1 MICU2 MICU1 MCU CA1 SLC12A6 CA2 CA4 DERL3 DERL1 SLC3A2 NR1H2 SLC5A1-1 ESYT1 MYLIP ERLEC1 HBA2;HBA1 ABCA12 SLC6A5 SLC6A2 SLC6A3 SLC2A10 HMOX1 HMOX2 RHAG RUNX1 ABCG2 SLC24A1 SLC24A4 SLC11A2 ABCD3 ATP6AP1 SLC44A5 SLC2A1 SLC2A2 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC17A5 SLC15A1 AVP LDLR SLC15A3 SLC20A2 SLC15A4 RSC1A1 ZDHHC8 HDLBP ABCC3 ABCC1 ABCG8 ABCC2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing NCBP1 SNRPF SNRPD2 SNRPD1 TXNL4A SNRPB SNRPD3 SRSF2 POLR2A POLR2B SRSF6 POLR2C SNRNP40 SRSF7 POLR2D POLR2G SRSF1 SNRPE-2 POLR2I DDX42 RNPC3 DDX23 NCBP2-1 YBX1 PDCD7 SNRPG-2 PRPF6 SNRNP35 PRPF8 SF3B4 SNRNP25 SF3B5 SF3B2 SF3B3 SF3B6 ZMAT5 POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L SF3B1 ZRSR2-1 SNRNP48 POLR2J;POLR2J2;POLR2J3 SNRNP200 ZCRB1 EFTUD2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation JUN SNW1 MAMLD1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 KAT2B AGO3;AGO1 H2AJ TNRC6B KAT2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 RUNX1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 CREBBP H2BC5 H2BC21 H2BC1 NOTCH1 RBPJ H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 MAML2 EP300 MAML1 PRKCI H2AC4 SIRT6 TP53 ELANE TFDP1 ELF3 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 E2F1 E2F3 H2AC14 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription HDAC1 SIRT1 RBBP4 SNAI1 SNAI2 ZNF217 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TCF12 RBBP7 TLE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 TWIST2 SUZ12 H2BC5 H2BC21 H2BC1 KDM1A SMARCA4 H2AC20 EED MPHOSPH8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 WT1 EZH2 TGIF2 ZMYM2 H2AC4 CTBP2 CTBP1 FOXQ1 DNTTIP1 MAPK1 ZBTB33 MAPK3 ZEB2 KMT5A PKM ZEB1 MCRIP1 HDAC2 H2AC14 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AB1 HSP90AA1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 PON2 ALOX5AP PON1 ALOX5 LTC4S PON3 GPX1 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase E2F2 CDK6 PPP2R1A ABL1 CDKN1A CDKN1B SKP1 CDK7 CCND1 MNAT1 CKS1B JAK2 CDKN2B LYN PPP2R3B CCND3 CCND2 UBA52 PPP2R2A;PPP2R2D CDKN2D CUL1 CDKN2C PTK6 CDK4 CDK2 PPP2CB;PPP2CA E2F4-1 RPS27A E2F5 CDKN2A PPP2R1B SKP2 UBB;UBC TFDP1 RBL2 TFDP2 RBL1 CCNE2 CCNE1 RB1 CCNH CDKN1C E2F1 E2F3 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 ST3GAL3 B3GALT4 ST6GALNAC6 B3GALT5 B3GALT2 B3GALT1 FUT2 FUT1 FUT4 FUT6;FUT5;FUT3 FUT7 B4GALNT2 FUT9 ST3GAL6 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) ADCYAP1R1 VIPR1 VIPR2 WNT9A RAMP2 GNG10 GNAS-1 GIPR GNG2 CRHR1 GNG5 SMO GNG4 GNG8 CRH WNT11 RAMP3 GNG13 PTH WNT4 IHH GNB2 GNB1 ADM PTCH1 IAPP GNB4 CALCA GNB3 WNT9B GHRH WNT5A RAMP1 GNB5 WNT1 FZD1 CALCRL FZD3 FZD2 GIP WNT6 FZD5 FZD4 CALCR FZD7 SHH FZD6 WNT2 FZD8 WNT3 PTCH2 WNT2B ADGRE1 ADGRE5 GCGR GCG SCT ADGRE3 FZD10 CRHBP GLP2R WNT16 GHRHR PTHLH WNT10B WNT10A FZD9 WNT3A DHH PTH1R UCN3 VIP GNGT1 PTH2R WNT8A WNT8B GLP1R CD55 WNT7B SCTR WNT7A ADM2 CALCB;CALCA ADCYAP1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation COG4 COG3 DPM1 COG2 SPTBN2 DPM2 DPM3 BET1L B4GALT6 CTSC B4GALT4 B4GALT5 ST8SIA5 CAPZA3 ST6GAL1 CTSA ACTR10 MOGS RPN2 SAR1B RPN1 ST3GAL4 GOLGA2 DCTN6 ST3GAL1 DCTN5 ST3GAL2 DCTN4 ST3GAL3 EDEM2 SLC35C1 GRIA1 NSF ANK3 NAGK MAGT1 AMDHD2 GFPT2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP ACTR1A AREG PSMC1 CANX CSNK1D MGAT5 MGAT1 COL7A1 UBA52 DYNC1I2 MGAT2 DCTN2 DCTN3 SEC24D-1 COPB1 MAN2A2 MGAT3 ST8SIA6 CHST8 ST8SIA2 FUCA1 EDEM3 ST8SIA3 VCP-1 CD59 RPS27A AMFR CD55 SYVN1 DERL2 TUSC3 EDEM1-1 UBB;UBC RNF5 RNF103 OS9 RNF139 TRIM13 DYNC1H1 UGGT2 UGGT1 RNF185 MARCHF6 TMEM258 DYNC1LI1 MVD DYNC1LI2 LHB ANK1 FUT8 MAN2A1 INS;INS-IGF2 OST4 CAPZB MAN1A2 MAN1C1 OSTC MAN1A1 STT3A CTSZ STT3B ST6GALNAC2 PRKCSH MGAT4A-1 SLC35A1 CHST10 DDOST DAD1 UMOD ASGR1 ASGR2 ST6GALNAC1 CMAS MANEA NPL MAN1B1 NANP ST6GALNAC3 NEU4 ST6GALNAC4 ST8SIA4 NANS SEC23A ST6GAL2 ST8SIA1 GNE CAPZA1 LMAN1 GANAB CAPZA2 SEC24B STX5 SEC24A YKT6 MGAT4C KDELR2 MGAT4B COPB2 COPA SEC24C ALG8 ALG9 COPE ALG6 MCFD2 ALG2 SERPINA1 ALG3 TMED3 PPP6C ALG1 TMED7 PPP6R1 PPP6R3 LMAN1L TMED9 COPZ2 GORASP1 COPZ1 SEC22A SEC22C NAPB ARF5 TMED10 STX17 LMAN2L UBXN1 USO1 NAPG NGLY1 MLEC LMAN2 SEC31B ENGASE ANKRD28 SEC23IP DHDDS CNIH1 CRYZL2P-SEC16B;SEC16B ARCN1 CNIH2 COPG2 FOLR1 COPG1 CNIH3 BET1 NAPA TFG HK1 SPTB NEU2 NEU3 ARFGAP1 NEU1 TRAPPC2L B4GALNT2 TBC1D20 PREB KDELR3 SEC13 ANK2 TGFA GOLGB1 SPTBN4 SPTBN5 TRAPPC3 TRAPPC1 GOSR2 TRAPPC4 TRAPPC5 TRAPPC9 ARFGAP3 COG1 ARFGAP2 ARF4-1 SPTA1 TRAPPC2;TRAPPC2B B4GALT1 TRAPPC6A TMED2-1 TRAPPC6B RAB1A RAB1B ALG14 ALG12 SEL1L ALG11 ST3GAL6 TRAPPC10 GLB1 ARF1 RFT1 SCFD1 SPTBN1 GBF1 PMM2 SPTAN1 CALR-1 KDELR1 SEC31A DYNC1I1 MIA2 MIA3 DERL1 DPAGT1 TMEM115 MPI DOLK SRD5A3 DCTN1 SEC22B ST6GALNAC5 ST6GALNAC6 ST3GAL5 CGA ALG5 NUDT14 MPDU1 FUT6;FUT5;FUT3 RAD23B F5 GMPPB FPGT GMPPA F8 GFUS DHRSX NUS1 B4GALT2 GMDS PMM1 B4GALT3 FCSK DOLPP1 ALG10;ALG10B GOSR1 SLC17A5 COG8 COG7 COG6 PDIA3 COG5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex HDAC1 BTRC RBBP5 AKT2 CTNNB1 TCF7 BCL9L SOX3 TLE4 TLE3 SOX6 TLE2 SOX7 TLE1 SOX4 TCF7L1 PYGO1 DPY30 SOX13 BCL9 SOX9 PYGO2 SOX2 CHD8 XPO1 AKT1 UBA52 SRY CTNNBIP1 LEF1 CBY1 YWHAZ WDR5 TCF7L2 RPS27A ASH2L MEN1 APC UBB;UBC CTBP1 KMT2B XIAP SOX17 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions IL11 CNTF LIF TYK2 CNTFR IL11RA CLCF1 LIFR IL31 OSM IL31RA OSMR IL6ST CRLF1 JAK1 CTF1 JAK2 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways ABCG5 NR1H3 MARK3 ADH1C;ADH1B;ADH1A DLL4 S1PR1 PPP1CC NEURL1 PDE3B IDE PTPRF SPOP CSNK1G2 DTX1 DTX2 DTX4 DNER DLK1 CNTN1 RAB4A PRKG2 LBR PDHB VAPB APOC2 PDK3 PDK2 PDK1 PDHX TIAM2 SPINT1 HPN MST1 LHB MST1R SPINT2 INS;INS-IGF2 MEMO1 ACBD5-1 LYPLA1-1 ZDHHC21 GLP1R DBT ALDH1A1 ULK1 NOS3 MTMR1 IQGAP1 MTMR4 ARF6 GGA3 ABCA1 MC4R EDNRB EDN1 EDN3 MC3R DLD MC1R MC5R ID1 NPFFR2 NPFFR1 NPFF HCRT QRFPR QRFP HCRTR2 HCRTR1 LETM1 FABP5 FABP6 FABP7 STK11 THEM4 PIK3CD PIK3CG OXTR RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R PRKCH TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 NTSR1 NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR2 GAST GPR39 EDN2 ANXA1 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 F2RL1 F2RL2 F2RL3 DGKG DGKE AHCYL1 CHRM1 DGKD GPR68 DGKB GPR65 DGKA CHRM5 PMCH ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ LTB4R2 DGKQ DGKK DGKI PIK3R3 DGKH ABHD6 PIK3R6 NTS PIK3R5 MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGL1 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 WASL RGS21 CCK KISS1 FFAR3;GPR42 GIP LEP HHIP BOC GAS1 CDON NGFR RXRB PTPRK EPS15L1 EPN1 ADAM12 GCGR LRIG1 FAM83D AAMP PAG1 FAM83A SPRY1 PTPN3 PPP1CA ICMT TLE5 C5AR2 C5AR1 C5 CD55 NDUFS3 MEF2D ANOS1-1 GRAP2 FSHB PIP4K2A CRHR2 PIP4K2B PIP4K2C IGF1 PLCG2 PLCB3 PLCB4 FES PLCB1 PLCB2 MAPK12 USP8 PTPN18 MATK WNT9A SFRP1 SFRP2 WIF1 AGT SOST CHRM3 ITPR1 ITPR2 ITPR3 PSAP CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 CCR8 CCR7 CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 PTPN13 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 CCL17 CCR10 CCL16 CCR1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 MTR-1 CXCL11 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 LHCGR FSHR GPHA2 TSHR GPHB5 CETP ARL4C EEPD1 ABCG1 CHD8 IGF2 PDYN FFAR1 DLAT RANBP9 OCRL NAB1 NAB2 LYL1 ARC VGF ABCD3 TRIB1 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 ID3 CDK5R2 ID2-1 TSHB SPTBN2 PTGES3-1 POMC APP RAP1B HGF DOCK7 GAB1 DNAJB1 MET AREG FGF7 FGFBP1 FGFBP3 FGF22 FGF3 FGF10 TCF7L1 WNT3A SOX2 MYB TSC2 TSC1 KDM1A DOCK10 DOCK11 KIF5B KIF5A KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF18A RCOR1 ITGA2 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CAPZB CRABP1 JAK2 DHRS3 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH14 RDH13 ALDH8A1 KIF2A KIF2C KIF2B DOCK2 CDC42 MFN1 MFN2 SH2B3 SH2B2 CENPE HGS ATP6V1H RAB7A LMNB1 CFL1 PAK2 RALA-1 HNRNPF FLT4 SLC1A5 RAMP2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 ADM SGK1-1 KAT5 CHEK1 EPO PRKAB1 CDH5 RRAGA RRAGC CALCRL RRAGB RRAGD E2F4-1 MAPKAP1 CDKN1A PRKAG1 PRKAG3 RPTOR CASP10 RASGRP3 FOS PPP5C RICTOR LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 USP7 USP2 SOX17 CDC25C ADCYAP1 ADCYAP1R1 FLRT2 MAPKAPK5 FLRT3 FLRT1 MDM2-2 ADRA2B SLC38A9 WWC1 PBX1 DLGAP5 PTCRA ACTA2 FCER2 TACC3 LINGO1 MAG OMG RTN4 RHEB PIN1 PRR5 MLST8 CASP2 RBL1 BIRC5 PRKAA1 SOCS6 AURKB PML MTOR BAX HDAC10 TRRAP PCSK5 ANGPTL3 HGFAC KDM1B RUVBL1 KDM4C-1 KDM3A HDAC8 KDM4A KDM4B CALCA REST APOD RANBP10 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM KIT NTRK3 VWF ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 EPOR FNBP1L MYLK PREX2 PREX1 WDR91 ANKFY1 CEP97 PRKCB FNBP1 STARD8 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 WDR81 DAAM1 NGEF CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR RHOT1 MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 GMIP LRRC41 CIT INCENP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 CENPA FGD1 CENPC FGD2 FGD3 LMAN1 NRTN FGD4 FGD5 NCAM1 CHN2 CHN1 FLNA PSPN STX5 GFRA2 GFRA4 YKT6 CENPT ARTN FARP2 FARP1 CENPU USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 CENPF CENPH ABI2 TAOK3 CENPI TAOK1 SHKBP1 CENPK ABI1 CENPL CENPM GOPC FILIP1 PKN2 CENPO PKN1 CENPP CENPQ UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SHC3 SWAP70 VRK2 FAM91A1 PTPRA TEX2 ARMCX3 SPTB CLIP1 PHIP MAD1L1 RHOBTB3 LIN7B RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 DVL3 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 NSFL1C ARPC2 ARPC3 COPS2 SPTBN4 NOXA1 SPTBN5 PLXNB1 NF2 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 NRP2 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 GFRA3 NCK2 SPDL1 NCK1 PLEKHG3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK DSG2 SPTA1 EVL PPP1R12B PFN2-1 SOS2 ROCK2 SRC SRF ROPN1;ROPN1B NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 LAMA1 NHS SLITRK5 CSK RBBP6 SPARC WHAMM WASF2 WASF3 RNF20 PPP1R14A PCDH7 CDC42BPB BAIAP2 PTPRS CDC42BPA MYO19 PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 BTK PFN1 CFTR GRB7 TMEM87A GARRE1 TWF1 KALRN MYL12B DSN1 SCFD1 SPTBN1 SCAI RCC2 LAMC3 STAM ZWINT PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 AKAP12 ITGA3 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC3 LAMA2 SPTAN1 LAMA4 GIT1 NDEL1 LAMB2 VAV3 CCDC115 RALBP1-1 RHOG RHOH RHOF RHOC RHOD VAV1 VAV2 RHOB CTTN RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU TAX1BP3 ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ARHGEF6 GNAT1 AMIGO2 WAS NOXO1 TRAK1 TRAK2 PAK1 PGRMC2 SAMM50 EMC3 CTNNA1 PAK3 DYNC1I1 PAK5 PAK4 BCAP31 GIT2 HDAC4 CAVIN1 MTX1 MYO9B MYO9A MPP7 NR1H2 DLC1 TRIP10 NR3C1 RAB9A B9D2 ESR1 ESYT1 SPC24 RAB9B SPC25 TJP2 AR ERCC6L RXRA RTKN PRAG1 ZWILCH BUB1B-PAK6;PAK6 RARA ARHGDIG PGR ARHGAP39 PPARG PMF1;PMF1-BGLAP ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 TP53 ARHGDIA ARHGDIB KNTC1 ARHGEF40 CYBB CYBA ARHGAP45 SGO1 ALDH3A2 SGO2 STAM2 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 CSNK2A2 ARHGAP12 NCKIPSD ARHGAP22 ARHGAP20 MYH14 MYH11 RHPN2 ECT2 MYH10 CSNK2B CPSF7 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP DLG4 ACTR3-1 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 ALS2 PEAK1 PDE5A ITGB3BP CCDC187 RAP1GDS1 MOSPD2 ARHGAP11A-1 FAM169A ADD3 PLA2G4A UACA GNA13 TRA2B STOM PTK2B BUB1 CLASP2 SPEN LIMK2 LIMK1 CSNK2A1;CSNK2A3 HSPE1 MGLL FMNL3 SLC4A7 TAS2R3-1 FMNL1 FMNL2 VIM HDAC11 BMI1 TNF YY1 TAS2R16 RING1 CCL3L1;CCL3L3;CCL3;CCL18 HDAC5 HDAC9 RNF2 TAS2R40 HDAC6 TAS2R41 HDAC7 STAT6 CBX8 STAT5A STAT5B GPAM CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 TAS2R39 NFATC1 PHC3 EGF IL5 ERBB2 PLCG1 EGFR YWHAE CCP110 PPP1CB RNF31 MAPRE1-1 XIAP OTUD7B PRKACA-1 SPATA2 TNFAIP3 SHARPIN PPP2R1A USP21 USP4 MIB2 TNFRSF1A BTRC CYLD RBCK1 YWHAG OTUD1 BIRC2 SKP1 BIRC3 TCF7 HSP90AA1 CDC73 OPTN-1 TERT LEO1 PPP1R12A BCL9L TLE4 TLE3 TLE2 TLE1 AXIN2 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PYGO1 BCL9 PYGO2 CKAP5 UBA52 PAFAH1B1 DYNC1I2 CUL1 PRH1-TAS2R14;TAS2R14-3 PRKAR2B ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 CLASP1 RPS6KA2 UBB;UBC RPS6KA1 OFD1-1 MEF2A DYNC1H1 MEF2C MAPKAPK3 NDE1 PLK1 MAPK8 TGIF1-1 CDK1 TPTEP2-CSNK1E;CSNK1E BCL2L11 TAS2R7 BAD STAT3 BCL2 TAS2R8 BCL2L1 GRM4 GRIN2B TAS2R1 CDH1 TAS2R4 COL1A2 HEY1 HEY2 ADAM10 ADAM17 PSEN1 SKI TAS1R2 TAS1R1 NCSTN TAS1R3 ELANE COL9A1 COL9A3 COL9A2 PLAT LAMC2 LAMC1 CASP3 DUSP5 TIMP2 DUSP2 KLK3;KLK2 DUSP1 TIMP1 PAQR3 PTPN7 CTSD FOXO4 FOXO3 PTPRJ MMP7 MMP2 MMP3 MMP9 MMP14 ZRANB1 MMP16 LAMA5 LAMA3 FURIN PLG PPM1A ITGA5 SPP1 YAP1-1 LAMB3 CMA1 E2F5 LAMB1 SST IL2RA STUB1 TRIM33 H2AC14 PDK4 TGFA MED1 WWTR1 YES1 FOXO1-1 RXRG CCNC-1 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SHC2 RALGDS CREBBP PTPRO IHH RALB CCND3 MAPK13 RIT1 RIT2 CHRM2 CHRM4 ADRB1 SMAD2;SMAD3 ADRB2 HTR4 SMARCA4 HTR6 HTR7 IL2 HRH3 IL3 H2AC20 HRH2 BMP2 H2AB2;H2AB3;H2AB1 HRH4 HTR1E TAAR8 EZH2 TGIF2 TAAR9 HTR1F TAAR6 HTR1D HTR1A ASH2L TAAR5 HTR1B TAAR2 SERPINE1 HTR5A JUNB TAAR1 RNF111 ADRB3 NCOA1 NCOA2 NCOA3 SCT RXFP4 MRGPRD RARG FZD10 RXFP1 RXFP2 RXFP3 UBE2D3-1 CRHBP RSPO3 GPR176 CMKLR1 NCOR2 AGTR2 KAT2B FPR1 H2AJ KAT2A GHRHR NR5A2 GALR3 TCF12 NCOR1 GALR2 GALR1 NPBWR1 RARB NPBWR2 WNT10B WNT10A GPR15 FZD9 GPR183 PLIN1 PNOC GPR18 GPS2 GPR27 MBD3 GPR25 CDKN2B GPR20 SUZ12 H2BC5 PTH1R UCN3 GPR37 WWP1 H2BC1 GPR35 GPR32 PTH2R RGR CSF2 PLPPR1 GATAD2B PLPPR2 ITGA2B GPR45 GATAD2A PLPPR3 PLPPR4 PLPPR5 WNT8A WNT8B GPR150 P2RY12 P2RY13 EP300 PF4;PF4V1-1 P2RY14 WNT7B GPR55 MEN1 SCTR WNT7A H2AC4 ADM2 MTNR1A MTNR1B GPR83 TBL1XR1 GPR84 CALCB;CALCA RLN3 ECE1 SKIL PRLHR DNMT1 INSL3 INSL5 KMT2B P2RY4 APLN ECE2;EEF1AKMT4-ECE2 VIPR1 VIPR2 ABL1 RRH PTGDR GPR37L1 KEL TAS2R42 GIPR CRHR1 NLN PENK CDK8 PPY PPP1R1B CDK5 CRH PDE3A ACTB-1 PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GPBAR1 GSK3B GAL OPRD1 PTGER4 DPY30 NPB RAMP3 CHD4 SOX9 PTH CHD3 PTGER2 PTGER3 CITED1 NPW RLN2;RLN1 PRLH SIN3A PARP1 H2BC21 MAS1 XK GHRH RAMP1 NPY2R RGS8 NPY WDR5 CAMK4 PDE8B PDE8A NPY1R PCP2 TBP ATP1B4 EED APLNR SUCNR1 H2AZ2;H2AZ1 WNT6 KCTD6 GRK3 CALCR GRK6 SMAD1 WNT2 SMAD4 WNT3 SMURF2 OPN3 SMURF1 PDE4D-1 SMAD6 PTCH2 ESR2 OPN5 SMAD7 PYY NR4A1 GPSM1 GPSM2 WNT2B NR2E1 ADGRE1 YBX1 GRM3 OPRM1 HEBP1 CAMK2B GRM2 CAMK2D ADGRE5 HDAC2 CAMK2A GRM7 GRM6 HDAC3 THBS1 GPER1 ADGRE3 HDAC1 HES1 GRM8 CAMK2G PDE4A GPSM3 MTA1 PTGIR NPY5R RBBP4 PDE4C OPRK1 GLP2R SSTR1 RBBP5 SSTR2 WNT16 SSTR4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SSTR5 POLR2E RGS14 OPRL1 POLR2F PTHLH CNR2 POLR2H CNR1 RBBP7 MTA2 RGS20 MTA3 S1PR3 POLR2L RGS22 S1PR2 ITGB3 S1PR5 S1PR4 RGS10 H2BC15;H2BC3;H2BC11;H2BC12 RGS12 PDE7B ACKR1 VIP FGB FGA SCD PDE7A SRY F2R DISP2 FGG SCUBE2 F2 F3 NOTUM KNG1 CCR6 CCR2 PRKX S100A9 S100A8 IL2RB THBS2 PSMD12 GALNT3 NOTCH1 PSMD11 PSMD14 MUC20 PSMD13 LEF1 RBPJ TAX1BP1 DLL1 CAB39 PSMA7 PSMD8 LFNG PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 RAG2 PSMB3 RAG1 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 TEC SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 ATP6V1E2 PSMC3 ATP6V1G1 PSMA1 ATP6V1G2 PSMC4 PSMC1 CTNNB1 IL5RA RAF1 RAB4B ATP6V0D1 ATP6V0D2 YWHAB ATP6V1A HSPB1 XPO1 AKT1 ATP6V0A2 PRKCD ATP6V0A4 PRKCA YWHAZ ATP6V1D ATP6V1C1 MAPKAPK2 ATP6V1F ATP6V0A1 ATP6V1C2 MAPK14 MAPK11 TCIRG1 EIF4G1 IFT172 GLI1 GLI3 GLI2 IFT52 IFT57 ATP6V0B DYNC2H1 IFT140 RPGRIP1L KIF7 ATP6V1B2 PTPN2 WDR35 ATP6V0C ATP6V1B1 RBX1 GNAS-1 IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 NUMB INTU ADCY4 ADCY3 TULP3 ADCY2 ADCY1 ADCY8 ATP6V1G3 ADCY7 ADCY6 ADCY5 PRKACB-1 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 WDR19 IFT122 FUZ ATP6V0E2;ATP6V0E1 ADCY10 ITCH MKS1 CGN F11R FKBP1A PARD3 CYSLTR1 CYSLTR2 GNAT3 SYK SPRED3 SPRED2 RASA4;RASA4B ADORA2B SPRED1 SYNGAP1 GNAZ GNAI3 HRAS RASA3 FYN RASA1 RASA2 OPN1SW CUL3 MKNK1 RASAL1 RASAL2 SPRY2 RASAL3 NRAS DAB2IP NF1 KBTBD7 MYD88 C3-1 SAA2;SAA1 CCNK NUP107 CCNT1 IL3RA IRAK4 TLR9 GTF2F1 GTF2F2 TGFBR3 GIPC1 NEDD4L AAAS UHMK1 EPGN NUP160 NUP85 ARRB1 TRAF1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ABHD17B ABHD17A CDK9 POLR2J;POLR2J2;POLR2J3 RCE1 CCNT2-1 NELFB CCR5 SEC13 NCBP1 NUP133 RANGAP1 CSF2RB CSF2RA GTF2A1 GTF2A2 CXCR4 POLR2A IRS2 POLR2B POLR2C POLR2D SOCS1 NUP43 GNAT2 PRKCG POLR2G WNT5B POLR2I RYK-1 WNT5A ROR1 RANBP2 ROR2 NLK PPP3R1 WNT1 FZD1 FZD3 FZD2 FZD5 NCBP2-1 FZD4 FZD7 FZD6 FZD8 GNAO1 CLTB ARRB2 PPP3CA PPP3CB PRKG1 PRICKLE1 PDE6B PDE6A NUP37 CHUK IKBKB WDR83 IKBKG RGL3 FKBP5 RGL2 NTRK1 PEA15 CLTC IL17RD RAPGEF2 CLTA AP2A1 SEPTIN7 CDC14A AP2B1 CDC14B NGF RASGEF1A AP2A2 ETV4 DNM1 IGF2BP1 DNM2 DNM3 MAPK6 MAPK4 AP2S1 DNAL4 SH3GL2 AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAT2 PPP2R1B APC PPP2R5E CDC37 ERBIN PHB ITGB1 RET GATA3 FGF2 WNT11 MECOM NEDD4 FGFRL1 WNT4 JAG1 WNT9B GFRA1 MYLIP GDNF ID4 ITGA8 ALK CD274 IRS1 PIK3R2 PIK3CB PTN PRDM1 PIK3R1 RNF41 IL2RG HIF1A PTPRZ1 MDK CUL5 MYC ALKAL2 ALKAL1 JAK3 FRS2 MYCN PIK3CA PTPN6 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 MKRN1 WWOX UBE2D1 RELA TCF7L2 NFKB1 IL6 GJA1 TBK1 AKT2 AKT3 DRD1 DRD2 DRD3 DRD4 PIK3R4 DRD5 ST3GAL4 SFN ST3GAL3 RPS27 DLG1 ADORA2A NRP1 ADORA3 ADORA1 IKBKE JAK1 PDGFRA TIAL1 FGF6 PTBP1 RBFOX2 PRMT1 RIPK2 ESRP2 HNRNPH1 ESRP1 HNRNPA1-1 TIA1 HNRNPM TYK2 CTNND1 RACK1 EPS15 PRKCE PCSK6 CFLAR GPC5 STAT1 TJP1 ZDHHC9 VCP-1 KPNA2 MAP3K7 EVC2 EFCAB7 CASP9 EVC GAS8 SPPL2B SPPL2A RPS6 CLIP3 NSMAF OTULIN PDE1B GOLGA7-1 TNS4 PDE1A TNS3 PDE2A PDE11A PDE10A DDX5 IRAK1 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CAV1 SQSTM1 FLT3 TAB3 TAB2 TAB1 GSK3A TRIM27 HSP90AB1 USP13 TNKS TNKS2 YWHAQ RNF146 FRK YWHAH PDPK1 OTUD3 CAMKK1 CAMKK2 C3AR1 EEF2K TRAF6 PIK3C3 CAB39L STRADA VHL STRADB PTPN11 ATP2A3 EIF4E EIF4B ATP2A2 ATP2A1 CALM3;CALM1 ACTN2 GRIN2D GNAL DLG2 GNGT1 DLG3 NBEA GABRB3 THBS4 GABRB2 THBS3 PDGFD GABRB1 RASGRF1 RGS9 RGS6 RGS7 CCT2 GABRG3;GABRG2 NEFL SPHK1 LRRC7 CCNE1 GABRQ ARL2 ULK3 DZIP1 GNA14 SPOPL GABBR2 GNG10 GABRA1 GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 CCT7 GRIN1 GNG13 CCT6A GNAQ GNB2 SNX3 GNB1 USP34 GNB4 IAPP GNB3 GNB5 RGS11 B4GALT1 POGLUT1 MCHR1 MAML2 MAML1 POFUT1 PRKCI TMED2-1 SIRT6 TFDP1 ELF3 TFDP2 MFNG MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 E2F3 ST3GAL6 RAB6A JUN VEGFB SNW1 VEGFC MAMLD1 VEGFD MAPK7 MAP2K5 CDKN1B LRRK2 ARHGAP35 SFPQ-1 RAC1 SSTR3 PELP1 NRG1 NRG2 ARAP1 RHOA EREG BTC DOK1 NRG3 NRG4 ELMO1 ELMO2 CRK ZDHHC7 DOCK1 PDE6D CAV2 HBEGF RHO KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN CBL SOCS3 GPNMB STAP2 NTF3 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 AMHR2 CER1 FST FOXH1 GFAP ZFYVE16 PSEN2 LTBP4 LTBP2 LTBP3 LTBP1 APH1A APH1B FASN TGFB2 TGFB3 GDF2 SMAD9 INHBB INHBA SMAD5 DRAP1 BAMBI MYF6 TCF4 BMPR1B MYF5 BMPR1A ACVRL1 BMP10 BMPR2 ITGB5 CHRDL1 ITGB8 PMEPA1 ITGAV ITGB6 AMH PSENEN MYOG HELLS SRRM1 NOG UCHL5 DDX39B KLF16 GREM2 MYOD1 STRAP PPP1R15A USP15 ACVR1B FSTL1 FSTL3 ACVR1C ACVR2B PGF ACVR2A FLT1 INHA SHB HCAR1 HCAR2;HCAR3 TRPC7 TRPC6 TRPC3 FOXA1 SMC3 FKBP4 RAD21 JUND GREB1 STAG1 CXCL12 STAG2 SMC1A TFF1 KANK1 CXXC5 TFF3-1 TRADD NRIP1 USF2 USF1 FASLG ZNF217 TRAF2 FOSB EBAG9 CASP8 TNFSF10 FAS ANGPT1 RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TEK FADD SHC1-1 PRKCQ RASGRP2 RASGRP1 RASGRP4 LYN UBE2D3;UBE2D2 NFKBIA NTRK2 TIAM1 BDNF CDK5R1 AATF MAGED1 TGFBR1-1 TGFBR2 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 BRAF MAPK3 CRKL FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 INSR GRB10 APOC1 GZMH;GZMB-1 APOC4 P4HB BUB1B CDC20 COL4A5 BUB3 MAD2L1 PRKAB2 EIF4EBP1 SHMT2 PDE1C GRK2 RDH11 PIP5K1A PIP5K1B PIP5K1C PRDM4 COL4A2 PRKAG2 COL4A1 COL4A4 COL6A2 SMPD3 COL4A3 COL6A1 SMPD2 COL6A3 COL6A6 COL6A5 IRS4 VPS29 SOX3 VPS35 SOX6 SOX7 SOX4 WLS SOX13 HECW1 VPS26A CCDC88C RSPO2 RSPO1 RSPO4 TMED5 LGR6 LGR5 LGR4 RAPGEF3 CTNNBIP1 PPARD KLHL12 RAPGEF4 CBY1 DACT1 ZNRF3 SYVN1 DERL2 OS9 IER3 FLT3LG PDGFB CD19 EGR1 CD28 SNAI1 SNAI2 STRN GAB2 PHLPP2 PHLPP1 IL33 CD86 KLB PGK1 CD80 ATN1 SALL4 MAF1 LTK PDGFRB FGF19 TNK2 FGFR4 AKT1S1 CRABP2 IL1RL1 TRAT1 RPS6KB2 PIK3AP1 SP1 ADRA1D ADRA1B ADRA1A TBXA2R GNA12 ARHGEF33 ARHGEF37 ARHGEF38 JAG2 PTEN FN1 SHH DUSP8 DUSP9 CILP NEURL1B CSN2-1 GRAP HHAT PPID FNTA AMOTL2 AMOTL1 MXD4 SAV1 PTPRU STMN1 MOB1A;MOB1B ADAP1 BEX3 STK4 STK3 FER LATS1 LATS2 PRKAA2 KDR MC2R GRB2 CNKSR2 CNKSR1 PEBP1 IGF1R IL6R TRIB3 CTBP2 CTBP1 APOE PCK1 APBB1IP CYP26A1 AVPR2 TLN1 GNAI1 GNAI2 GCG FNTB;CHURC1-FNTB HES5 ARAF DHH HEYL PORCN PDHA1 KSR1 KSR2 LRP5 LRP6 CYP26B1 MIB1 SH3GL3 SH3GL1 VCL CARM1 ERLEC1 DKK1 DKK2 DKK4 BRAP TPH1 MRAS ADH4 CGA HMOX2 RNF43 BAG4 DUSP16 DUSP10 CX3CR1 PTPN12 PLIN3 SH3KBP1 AVPR1B KREMEN1 KREMEN2 AVPR1A RDH5 CKB AVP SHOC2 AXL ABCG8 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma EREG BTC EGF PLCG1 AREG TGFA EGFR HBEGF EPGN GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense SFN FURIN FNTB;CHURC1-FNTB FNTA GBP2;GBP3;GBP1 PGGT1B GBP5-1 PIM1 ACTG1 CASP1 ACTB-1 GBP7;GBP4 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency OTC SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination DRP2 TEAD1 SCD5 WWTR1 UTRN MAG CYP51A1 PRX SOX10 POU3F2 SMARCA4 SREBF2 NAB1 LAMA2 NAB2 YAP1-1 DAG1 LAMB1 EGR2 MBP ADGRV1 PMP22 POU3F1 LAMC1 MPZ HDAC2 ADGRG6 HMGCR INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins NUP133 NUP107 NUP188 RANGAP1 NPM1-2 NUP50 POM121;POM121C RCC1 NUP54 NUP210 NUP93 KPNB1 NUP205 NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 RANBP1 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ16 KCNJ1 KCNJ10 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance DAXX ATRX TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PPP2R1A ABL1 ITGB1 GNA11 CHUK ITGAV CAPNS1 IKBKB CAPNS2 ITGB3 IKBKG CAPN2 GNAQ PTK2 NFKBIA PPP2R2A;PPP2R2D VCL ANXA2 STAT1 PTPN1 RELA PPP2CB;PPP2CA ITGA5 YAP1-1 PPP2R1B NFKB1 IKBKE PIEZO1 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR52A5-2 OR2V2 OR11A1 OR8A1 OR8I2 OR10G9;OR10G7 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 LHX2 OR56B1-1 OR10W1 OR8B3;OR8B2-1 OR5B2 OR5D14 OR5D13 EBF1 OR52M1 OR10V1 OR4C12 OR6C3 OR5A2 OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 OR4D11 OR4D10 OR2Z1 OR6A2 OR9G4 OR4E1 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5B12 OR5AP2 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 ANO2 OR4C3 OR3A2 OR3A1 OR8K3 OR8K1 OR4C11-1 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 OR6F1 OR2T2;OR2T35 OR51M1 OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 OR51A7 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 OR6Q1 OR11H1;OR11H12 OR52I1;OR52I2-1 OR4F21;OR4F16;OR4F29;OR4F3 ADCY3 OR9G9;OR9G1 OR7C1;OR7C2-9 OR51G2 OR51G1 OR1F1 OR2H2 OR4L1 OR5B3-13 OR6P1 OR10Q1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2AP1 OR2B11 OR4A47-3 OR51F2 OR5M9 OR51F1 OR2G6 OR4K5 OR4K3 OR5M3 OR4K2 OR4K1 OR10P1 OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 GNAL GNG13 GNB1 LDB1 CNGA2 CNGA4 OR11H4 OR2M4 OR4C13;OR4C46-2 OR6K3-1 OR1K1 OR4K17 OR1S1;OR1S2 OR4Q3 OR11H6 OR8G1;OR8G5 OR1J4 OR11G2 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR2K2 OR1I1 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR10C1 OR5B17-3 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 OR5T1 OR6V1 OR10G6 OR6C4-1 OR10K1-1 OR52W1 OR5AS1 OR4F5;OR4F17;OR4F4 OR2T6 OR13C9 OR2T1 OR13C8 OR2L13 OR4X1 OR9A4 OR51T1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 OR2Y1 OR8D4 OR56B4 OR8D1 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR56A4 OR10A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 OR8B8 OR2W1 OR8B4 OR13F1 OR12D3 OR5AU1 OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling PLA2G4A GNA14 GNG10 GNA15 GNG2 ADCY9 GNG5 GNG4 PRKAR1B GNA11 PRKAR1A GNG8 CDK5 PPP1R1B ADCY4 PPP3CC ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNAQ GNB2 PRKAR2A GNB1 PRKCG POMC GNB4 GNB3 ITPR1 PDYN ITPR2 GNB5 ITPR3 CAMK4 PPP3R1 PDE1C CAMKK1 GRK2 CAMKK2 GNAT3 PDE4D-1 PPP3CA PPP3CB GNAI1 GNAI3 GNAI2 OPRM1 CAMK2B CAMK2D CAMK2A PRKACA-1 PPP2R1A CAMK2G PDE4A PPP1CA PDE4C CALM3;CALM1 GNAL GNGT1 PRKCD NBEA PRKCA PPP2CB;PPP2CA PRKAR2B PLCB3 PPP2R5D PLCB4 PPP2R1B PLCB1 AHCYL1 PLCB2 KPNA2 PRKX MAPK1 PDE1B PDE1A CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation S100A8 HECTD1 HECTD2 TLR2 ASB10 HECTD3 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXL16 CDC20 FBXL13 FBXL14 B2M FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 TRIM36 ASB7 STX4 TRIM37 ATG14 ASB4 ASB5 ASB2 TRIM32 SAR1B ASB1 PIK3R4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 MIB2 BTRC PSMC3 PSMA1 RBCK1 PSMC4 PSMC1 SKP1 CANX FBXW11 UBA52 SEC24D-1 CUL1 RPS27A UBB;UBC UBE2V1 RBX1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2N ITCH LRRC41 VAMP3 PIK3C3 BECN1 SEC23A FCGR1A CUL3 CTSS VHL SEC24B KBTBD7 SEC24A MYD88 SEC24C CTSV;CTSL HMGB1-1 FBXO32 NEDD4L NCF1 TRIM63 NCF2 FBXO4 NCF4 FBXO6 VAMP8 FBXW4 PSME2 FBXW10;CDRT1 FBXW5 FBXW7 FBXW9 ELOC-1 FBXW2 ELOB STUB1 SEC13 SNAP23 TIRAP SOCS1 FBXL3 FBXL5 TLR6 RNF111 RBBP6 CD36 UBE2D3-1 CHUK BTK UBA7 HSPA5 UBE2L6 HERC5 IKBKB IKBKG LRR1 WWP1 CCNF KEAP1 CBLB SOCS3 DCAF1 SH3RF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 TRIM21 FBXO7 FBXO9 CALR-1 HERC6 TRAIP-1 WSB1 FBXO2 RNF123 S100A1 RNF126 HECW2 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 ERAP2 SIAH1 ERAP1 LNPEP TAP2 MEX3C TAP1 UBAC1 TAPBP FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B ITGB5 GAN PRKN RNF130 GPR75-ASB3;ASB3-1 ITGAV HUWE1 KLHL2 KLHL3 SEC31A UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 KCTD6 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 SMURF2 SEC61A2 MRC2 UBE2E2 SMURF1 LMO7 SEC61A1 SEC61G FBXO10 SEC61B FBXO11 PSME1 KLHL41 CYBB KCTD7 SEC22B CYBA RNF41 PSMB10 PSMB8 KLHL42 PSMB9 UBE2V2 CD207 CUL7 RNF34 CUL5 UBA6 UBA5 CUL2 UBR4 KLHL11 MRC1 KLHL13 UBR1 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 LY96 UBE2F UBE2H UBE2B KLHL25 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 CD14 FBXO30 KLHL20 TLR4 FBXO31 CDC34 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBE2D3;UBE2D2 UBA1 FGB UBE2K FGA TRIM71 RNF14 KBTBD13 FGG UFL1 UBE2Q1 UBE2Q2 UBE2D1 TRIM69 UNKL ANAPC10 DTX3L ANAPC11 PJA2 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 CDC27 RNF138-1 THOP1 ANAPC7 RNF213-2 MGRN1 UBE2C ASB13 UBE2E1 ASB14 RNF6 ASB11 UBE2S RNF7 CDC16 ASB12 ANAPC4 ASB17 ANAPC5 RNF4 ANAPC1 RCHY1 ANAPC2 ASB18 FBXL22 ASB15 TLR1 ASB16 FBXL20 PDIA3 ZNRF1 S100A9 ZNRF2 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD BCAN VCAN DCN CHST3 CSPG5 NCAN BGN NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK RELB FBXW11 UBA3 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A MAP3K14 PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 KAT5 POLH CHEK1 HUS1 MUS81 C1orf112 EME1-1 BRCA2 DNA2 RAD51AP1 RHNO1 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 SIRT6 PALB2 SPIDR SLX1A;SLX1B ATRIP BARD1 SEM1 RAD17 ATM ATR BRCA1 BABAM1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 RAD51D H2BC5 PCNA UBA52 WRN H2BC1 RPA1 HERC2 RPA2 CDK2 RPA3 RPS27A RAD1 UBB;UBC CLSPN MRE11 NBN RTEL1 ABL1 BLM PIAS4 RAD51 UBE2I POLD1 UBE2N RAD9B H2BC21 PARP1 RAD9A RAD51B RAD51C EXO1 SUMO2 TOPBP1 RFC5 RFC3 RFC4 RFC2 UBE2V2 RBBP8 TP53BP1 RAD50 POLQ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 RNF168-1 PPP4R2 TIPIN TIMELESS PPP4C POLK RAD52 POLE RFC1 PARP2 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 NSD2 POLD3 POLD4 POLD2 XRCC1 POLE4 FEN1 BRIP1 ERCC4 POLE2 RNF4 ERCC1 POLE3 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism AKR1B1 GALT PGM1 GALM-2 GALE GALK1 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism ASRGL1 KYAT1 PAH QDPR PCBD1 IL4I1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways SFN YWHAZ YWHAQ YWHAE YWHAB CAV1 YWHAH PDPK1 YWHAG AKT2 AKT3 AKT1 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases PDZD3 GUCY2C DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 OGG1 H2AC14 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME SLC28A2 SLC29A1 PNP-1 SLC29A3 SLC28A3 NT5C2 NME2 ADA ITPA ADK NME1 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport GLTP ESYT3 PLEKHA8 ARF1 ESYT2 CPTP CLN3 ESYT1 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment RIPK3 UBE2D1 UBE2V1 UBE2D3-1 TLR3 BIRC2 CHUK TICAM1 BIRC3 RPS27A RIPK1 TRAF6 UBB;UBC IKBKB IKBKG UBE2N UBE2D3;UBE2D2 UBA52 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion PPIA ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 FRS2 BDNF SOS1 PTPN11 HRAS FRS3 NRAS NTRK2 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System STOM LIMK1 AGPAT2 SERPINB1 DTX4 STAT6 NFATC2 NFATC1 PLCG1 PRKACA-1 TNFAIP3 PPP2R1A BTRC CEP290 CYLD BIRC2 SKP1 BIRC3 HSP90AA1 OPTN-1 FBXW11 TTR RAB14 VAPA UBA52 CUL1 TANK FUCA1 ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 UBB;UBC RPS6KA2 RPS6KA1 MAP3K8 MEF2A DYNC1H1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 TUBB4B COLEC11 MAPK8 MAP2K7 HSP90B1 TUBB4A;TUBB;TUBB8B;TUBB8 MAPK10 TNIP2 TXN PRKDC BCL2 BCL2L1 DERA APEH CAPN1 ADAM10 ADAM8 CR1L;CR1 PSEN1 NCSTN A2M ELANE PTGES2 PLAUR PLAU HRG CTSS SERPINB6-2 MMP25 PAFAH1B2 CTSK CASP3 TIMP2 CTSG CTSD CTSB PTPRJ CTSV;CTSL MMP8 MMP9 OTUD5 DDX41 IDH1 ITGAL CD44 CRP COLEC10 FCN2;FCN1 TBC1D10C PRSS3;PRSS2;PRSS1 HK3 KLKB1 PTPN4 RAB31 LGALS3 H2AC14 PDXK NOS3 YES1 ALDH3B2;ALDH3B1 TRAPPC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP RAB27A MAPK13 GDI2 H2AC20 H2AB2;H2AB3;H2AB1 CAT IQGAP1 RETN CD36 CYB5R3 RAB10 RAB18 UBE2D3-1 ECSIT FPR1 PGAM1 H2BC5 H2BC1 EP300 H2AC4 DBNL GSN GPR84 CRCP POLR3GL POLR3A POLR3B FABP5 ABL1 POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K ACTB-1 KPNB1 H2BC21 H2AZ2;H2AZ1 MME POLR1C POLR1D ADGRE5 FPR2 ADGRE3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H POLR2L PROS1 H2BC15;H2BC3;H2BC11;H2BC12 CD177 FGB FGA FGG F2 PTAFR EPPIN;EPPIN-WFDC6 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 LYZ-1 GMFG DEFB1 SERPING1 CLU MCEMP1 DEFB109B KNG1 RNF216 BPIFA1 HP;HPR REG3G;REG3A-1 CCR6 F12 FUCA2 ATP7A PGLYRP1 AHCYL1 CAMP OLR1 CCR2 DEFB131B;DEFB131A DEFB119 YPEL5 DEFA6;DEFA4;DEFA5 DEFB118 DEFB116 TOM1 ARSA SLC11A1 ARL8A DEFB114 RNASE6 NIT2 DEFB110 TLR1 RNASE3;RNASE2-2 ACP3 BPI S100A9 SNAP29 S100A8 LTF RNASET2 TLR2 TMBIM1 DEFB129 TRIM56 DEFB128 CANT1 DEFB127 DEFB106B;DEFB106A MUC12 DEFB125 MUC15 DEFB123 DEFB121 ART1 ITLN2;ITLN1-2 PDZD11 MUC3A RNASE7 MUC5AC CHGA DEFB135 DEFB107A;DEFB107B C6orf120 METTL7A-1 S100A7A;S100A7 CFP SLPI DEFB132 ATOX1 CRISPLD2 DEFB130B;DEFB130A CTSA DEFB105A;DEFB105B TMEM63A CD4 SYNGR1 BPIFB2 BPIFB1 MUC1 NBEAL2 BPIFB4 MUC2 BPIFB6 LCN2 DEFB103A;DEFB103B MUC7 DEFB4A;DEFB4B MUC4 MUC6 FCER1A PSMD12 MUC17 FCER1G PSMD11 PSMD14 MUC5B PSMD13 MUC20 WASL MUC21 RAP2B TAX1BP1 PSMA7 CAB39 DNAJC3-1 C1orf35 PSMD8 PSMB6 PSMB7 GCA PSMD6 PSMB4 LAT2 PSMD7 PSMB5 SRP14 PSMB2 ENPP4 PSMB3 PSMD2 PSMD3 IRAG2 PSMB1 ADGRG3 PSMD1 GGH ADA2 ADRM1 MS4A3 TNFAIP6 CHI3L1 PSMC2-1 MS4A2 PSMA2-1 PSMA5 ATP8A1 ACAA1-1 TEC SEM1 PSMA6 AAMP PTX3 PSMC5 PSMA3 FRMPD3 PSMC6 PSMA4 TOLLIP ATP6V1E1 AHSG PSMC3 ATP6V1E2 PLEKHO2 PSMA1 ATP6V1G1 GRN PSMC4 ATP6V1G2 PSMC1 ATP11B CTNNB1 TMEM179B ATP11A RAB3D RAB44 LAMP1 LAMP2 KCMF1 ILF2 RAF1 RAB37 RAB4B ATP6V0D1 FGL2 ATP6V0D2 HSPA1A;HSPA1B RAB24 ATP6V1A CPPED1 KRT1 C1QB CPB2 TXK CD81 C1R ATP6V0A2 VAT1 C5AR2 PRKCD CFI ATP6V0A4 CSTB SVIP C5AR1 C8B QPCT ATP6V1D C8A COTL1 MAPKAPK2 ATP6V1C1 CPN2 C2 COPB1 ATP6V1F CPN1 ATP6V0A1 LPO C5 ATP6V1C2 C8G C6 ATP8B4 C7 CLEC12A C9 TMEM30A SCAMP1 CD59 SERPINB3;SERPINB4-1 CD55 CR2 CFHR1;CFHR2 CFH-3 C1QC PIGR HSPA8 TMC6 SERPINB10 MAPK14 SERPINB12 MAPK11 PKM TCIRG1 LRG1 OLFM4 PTPRB ATP6V0B PRCP ATP6V1B2 PNP-1 VPS35L ATP6V0C ATP6V1B1 DHX58 DHX36 TREM2 SURF4 GRAP2 PRG2 KLRC4-KLRK1;KLRK1 PRG3 KLRC4;KLRC3;KLRC2;KLRC1 ORM2;ORM1 TYROBP QSOX1 KLRD1 LCP2 CD53 CD63 PGRMC1 CREG1 CD68 ATP6V1G3 MPO OSTF1 CD93 PRKACB-1 DOK3 CTSZ TARM1 ANPEP MVP PDAP1 ATP6V0E2;ATP6V0E1 S100P ITCH ATP6AP2 ABCA13 NHLRC3 UNC13D RNF125 A1BG CRACR2A PRDX4 S100A11 PA2G4 CD3G SERPINA3 SYK FGR HCK NFAM1 AGA CARD9 HRAS ERP44 FCGR3A;FCGR3B FYN SLCO4C1 FCGR1A GHDC EPX ALPK1 CLEC4A NLRX1 NRAS CLEC4D CLEC4E AGER S100A12 BRI3 N4BP1 HVCN1 USP18;USP41 CFD CLEC7A MYD88 C3-1 CFB CLEC6A NFKBIB SAA2;SAA1 NKIRAS1 KCNAB2 NKIRAS2 IKBIP IRAK4 PELI1 PLCG2 TLR9 LRRC14 SIGLEC15 PTPRN2 USP14 PELI3 STK11IP PELI2 NLRC5 TIFA HMGB1-1 DNASE1L1 MAP3K1 ATAD3A;ATAD3B CNPY3 DPP7 SIGIRR DNAJC13 IRAK3 CRISP3 HEBP2 CMTM6 MLEC FTH1 XRCC6 XRCC5 VAMP8 PTPRC RAB5C ASAH1 TXNDC5 MAPK12 AP1M1 FTL-1 AOC1 IGF2R GYG1 SOCS1 ITPR1 ITPR2 ITPR3 PPP3R1 PSAP PPP3CA PPP3CB HEXB GM2A GLB1 GUSB ARSB CHUK UBA7 CXCL2;CXCL3;CXCL1-1 DDX58 ISG15 UBE2L6 HERC5 PFKL IFIH1 CXCR1 IKBKB IMPDH1 TRIM25 IMPDH2 CXCR2 IKBKG AP2A2 PPBP DNM1 DNM2 DNM3 TRIM21 PPP2CB;PPP2CA PPP2R5D PPP2R1B ATG7 MGST1 NDUFC2;NDUFC2-KCTD14 HUWE1 PLAC8 GLIPR1 ITK MANBA NME2 AMPD3 PIK3R2 PIK3CB ALDOC PIK3R1 ALDOA UBR4 PIK3CA PTPN6 DNAJC5 ALOX5 UBA3 UBE2K UBE2D1 RELA MAN2B1 NFKB1 NAPRT SLC15A4 SLC2A5 ICAM2 TBK1 ACTR1B CTSH CTSC B2M RELB ACTR10 TRIM32 ITGB2 PIK3R4 RIPK3 APP NLRC4 MEFV NFKB2 PANX1 GSDME PYCARD P2RX7 PSTPIP1 AIM2 CASP1 TXNIP NLRP1 ATG12-1 SUGT1 ATG5 MAGT1 IKBKE TOMM70 RIPK2 RAP1B ANO6 PRKCE PLPP5 PLPP4 HSPA6 MYO10 EEF1A1 MYO5A SIKE1 MYO1C CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 TLR8 TLR7 RNF135 PKP1 STING1 VCP-1 MAP3K14 DSC1 MAP3K7 GSDMD TNFRSF1B CASP9 GOLGA7-1 MASP1 UBE2V1 NOS1 TKFC IRAK1 IRAK2 NLRP3 IST1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E MAVS UBE2N TAB3 TAB2 RBSN TAB1 HSP90AB1 PRKCSH FRK PDPK1 DDOST C3AR1 IRF3 DOCK2 IL18 HBD;HBB TRAF3 CDC42 IL1B MBL2-1 TRAF6 IRF7 PIK3C3 NOD1 NOD2 CAPZA1 CAPZA2 MGAM IFNB1-4 PTPN11 CHIT1 NOS2 CALM3;CALM1 ATP6V1H RAB7A CNN2 CHRNB4 CFL1 PAK2 ANXA2 MIF CCT2 LRRC7 CCT8 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 PRDX6 B4GALT1 PECAM1 RAB6A JUN CDK13 MAPK7 RAC1 RHOA CASP10 ELMO1 ELMO2 CRK FOS DOCK1 NFATC3 P2RX1 LAMTOR2 LAMTOR1 LAMTOR3 VNN1 MRE11 ITGAV MAP2K6 PIN1 COMMD9 CASP2 TRPM2 COMMD3 APAF1 CAND1 TICAM2 TLR3 LY96 TRAF2 TICAM1 CASP8 PADI2 RIPK1 CD14 FADD TLR4 CDC34 PRKCQ CARD11 BCL10 RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 ICAM3 NFKBIA TREM1 LAIR1;LAIR2-1 SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 OSCAR CD300E MAP2K2;MAP2K1 RAP1A MAPK1 MAPK3 SIGLEC5;SIGLEC14 SOS1 NPC2 APOB SELL CST3 TSPAN14 LTA4H LGMN ROCK1 MUC13 DSP CD47 CKAP4 DSG1 SIRPA;SIRPB1;SIRPG SIRPB1 RAB3A LBP GSTP1 CYFIP2 CYFIP1 NCKAP1 CD180 LY86 WASF1-1 ITGAM EEA1 WIPF1 TASL IRF5 WIPF2 WIPF3 ACLY DYNC1LI1 CD19 SLC27A2 GAB2 IQGAP2 NCKAP1L JUP SDCBP ARHGAP9 CASP5;CASP4 ARPC1B ARPC1A HPSE SNAP25 ALAD PGM2 PGM1 C1S SERPINA1 DHX9 ABI2 BST2 ABI1 PPIE NCF1 NCF2 NCF4 STK10 NEU1 NFASC ARPC4 ARPC5 BST1 ARPC2 ARPC3 RAB5B NF2 SNAP23 TIRAP CAP1 CD33-1 NCK1 ACTR2 LCK GAA APRT AGL-1 TLR6 TLR5 WASF2 WASF3 ORMDL3 BAIAP2 CGAS BTK HGSNAT C4BPA C4BPB LOC110384692;C4A;C4B_2;C4B DSN1 PTK2 FAF2 ITGAX TLR10 C1QBP STBD1 SPTAN1 VAV3 S100A1 RHOG RHOF IFI16 VAV1 NLRP4 TREX1 VAV2 DEGS1 WAS PAK1 PCBP2 PAK3 MYO9B ZBP1 VCL RAB9B LRRFIP1 DYNLT1 GALNS ACTG1 GLA PPIA CDA ARG1 TP53 CYBB ARMC8 CYBA ARHGAP45 PLA2G2A-1 BIN2 CPNE3 GNS DGAT1 NCKIPSD HMOX1 DDX3X-1 HMOX2 CSNK2B CLEC5A VTN TCN1 PLD4 DIAPH1 PLD1 PYGB PLA2G6 GPI PLD3 PLD2 PYGL UNC93B1 ACTR3-1 CLEC4M;CD209-2 SLC44A2 LPCAT1 MOSPD2 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism GDPD1 GDE1 GDPD3 ENPP6 GDPD5 PNPLA6 PNPLA7 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs NEIL3 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GNS DCXR PPP1R3C GLB1 HYAL1 IDS GUSB ARSB HGSNAT RPIA EPM2A GBE1 NAGLU GYG2 GYG1 G6PC1 GYS2 KHK GYS1 G6PC3 UBA52 GAA TALDO1 GALNS SI LCT RPS27A SGSH UBB;UBC ALDOB IDUA SLC37A4 NHLRC1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions GJA1 CLTB DNM1 DNM2 DAB2 CLTCL1 CLTC CLTA SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 VEGFB VEGFC FLT4 VEGFD KDR VEGFA PGF GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism GLB1L2 SMPD3 GBA GLB1L GLB1 SMPD2 SMPD4 SMPD1 ARSD-1 ARSL ARSB ARSJ ARSK ARSH ARSI ARSG CTSA ENPP7 SUMF2 SUMF1 STS GBA2 GALC PSAP GLA M6PR NEU2 ASAH1 NEU3 ASAH2 NEU1 ARSA HEXB GM2A HEXA GLB1L3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPS14 NCBP1 RPS17 RPS16 RPS19 RPS18 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPS13 RPS12 UPF2 ETF1 RPL27A RPL10;RPL10L-1 NCBP2-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A PPP2R1A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 PPP2CB;PPP2CA RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 DCP1A EIF4G1 RPSA EIF4A3 CASC3 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 SMG1 RPL8 RBM8A SMG9 SMG7 RPL9 SMG8 RPL6 SMG5 SMG6 RPL7 UPF1 RPS4X MAGOH;MAGOHB RPL35 RPL38 RPS3A UPF3B RNPS1 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 PPP2R2A;PPP2R2D RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 RBX1 ACTA2 DLL4 PSENEN TACC3 HEY1 HEY2 CREBBP JAG1 ADAM10 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 RBPJ PSMA7 PSMD8 PSEN1 PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 NCSTN PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAML3 NOTCH2 ADRM1 NOTCH4 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 HES1 PSMC5 PSMA3 SNW1 PSMC6 MAMLD1 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 KAT2B KAT2A HES5 AKT1 UBA52 YWHAZ CUL1 EP300 RPS27A PSEN2 UBB;UBC FLT4 APH1A APH1B CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 OGG1 H2AC14 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage GSDMD CASP3 IL18 CASP5;CASP4 IL1B TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR1-1 ARRB2 TGFBR2 TGFBR3 GIPC1 TGFB2 TGFB1 ARRB1 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I VWF ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism ACOT8 ELOVL1 SCP2 ELOVL2 ELOVL3 FADS2 ACSL1 HSD17B4 ABCD1 ELOVL5 ACAA1-1 FADS1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSEN2 YWHAZ APH1A APH1B NOTCH4 PSEN1 DLL4 JAG1 PSENEN NCSTN ADAM10 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling SOCS3 STAT1 TYK2 UBE2D1 STAT5A STAT3 UBE2D3-1 STAT5B CSF3 RPS27A SYK UBB;UBC HCK RNF7 ELOC-1 JAK1 ELOB CSF3R CUL5 JAK2 LYN UBE2D3;UBE2D2 SOCS1 UBA52 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 IRS4 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 IGF1R PIK3R4 THEM4 IGF2 PDPK1 IGF1 TRIB3 IRS1 PIK3C3 PIK3R2 CILP PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins PROC F2 F7 FURIN F9 PROS1 F10 GAS6 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors RBFOX1 MEF2C PPARG GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism EXT1 ABCC5 EXT2 CHSY3 PXYLP1 FMOD LUM B4GALT6 CHSY1-1 B4GALT7 UXS1 B4GALT4 CHPF B4GALT5 NDST2 NDST1 SLC26A11 NAGLU CSGALNACT1 NDST4 NDST3 CHP1 PRELP CSGALNACT2 SDC4 KERA B3GAT3 CEMIP SDC2 B3GAT2 SDC3 B3GAT1 SLC26A2 SLC26A1 ST3GAL4 HMMR ST3GAL1 ST3GAL2 ST3GAL3 HS3ST3A1 HYAL2 B4GALT1 SDC1 IDUA HEXB NCAN HEXA BGN GLB1L3 ST3GAL6 GLB1L2 VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 IDS CHPF2 CSPG5 GUSB ARSB CHST6 CHST7 GPC1 GPC3 GPC2 CHST1 GPC5 HPSE2 GPC4 SLC35B3 CHST2 GPC6 SLC35B2 CHST3 HS6ST1 HS6ST2 HS6ST3 EXTL2 AGRN HAS1 HAS3 HAS2 HS3ST3B1 EXTL3 SLC35D2 STAB2 SLC9A1 DSEL OGN HSPG2 HS3ST5 BCAN HS3ST6 HS3ST4 HPSE HS3ST1 HS3ST2 B3GALT6 B4GAT1 GALNS UST XYLT2 B3GNT7 XYLT1 B3GNT4 DSE FAM20B B3GNT3 GLCE B3GNT2 SPAM1 GNS CHST11 CHST12 CHST15 CHST13 CHST14 CTSV;CTSL LYVE1 DCN CD44 OMD ACAN B4GALT2 B4GALT3 SGSH HS2ST1 PAPSS2 PAPSS1 SLC17A5 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 CBL ABL2 FLT3LG SLA2 PTPRJ RPS27A SH2B3 UBB;UBC CSK SLA SOCS6 FLT3 SOCS2 UBA52 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair FEN1 PARG POLB PARP2 APEX1 ADPRS PARP1 LIG1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity CDK6 PML PTPN11 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 SRC AGO3;AGO1 TNRC6B CCND1 CBFB RUNX1 CCND3 CCND2 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair RPA1 RPA2 POLD3 POLD4 RPA3 POLD2 RFC5 RFC3 LIG1 RFC4 POLE4 FEN1 RFC2 POLB POLE POLE2 RFC1 APEX1 POLE3 POLD1 PCNA DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex TGIF1-1 ITGB1 ITGB5 ITGB8 PMEPA1 CDK8 ITGAV WWTR1 ITGB6 PRKCZ PPP1CC UCHL5 COL1A2 CCNC-1 STRAP PPP1R15A USP15 SP1 PARP1 SMAD2;SMAD3 ATP1B4 CGN F11R FKBP1A TGIF2 PARD3 SKI ITGA8 E2F4-1 PARD6A SMAD4 SMURF2 MTMR4 SMURF1 SERPINE1 TFDP1 JUNB SMAD7 RNF111 TFDP2 RBL1 YBX1 MYC PPP1CB HDAC1 SNW1 PPP1CA CCNK UBE2D3-1 USP9X CCNT1 NCOR2 TGFB1 NCOR1 RHOA TGFBR3 ITGB3 NEDD4L CDKN2B XPO1 UBA52 CBL UBE2D1 FURIN PPM1A CDK9 EP300 CCNT2-1 RPS27A E2F5 MEN1 TGFBR1-1 LTBP4 ARHGEF18 TGFBR2 LTBP2 UBB;UBC LTBP3 LTBP1 MAPK1 TGFB2 MAPK3 TGFB3 SKIL STUB1 TRIM33 BAMBI LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis MVD FDPS GGPS1 MVK IDI1 HMGCS1-1 FDFT1 IDI2 SQLE PLPP6 LSS ACAT2 PMVK KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs ALK EML4 NPM1-2 STRN HIP1 BCL11A PPM1B FN1 PRKAR1A CLTC BIRC6 EIF2AK3 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA NUP214 PRKCD PRKCA ANP32A;ANP32D ELAVL1 XPO1 SET-1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse MYL6 RND1 ARHGEF11 ROCK2 LIMK2 LIMK1 MYH14 ARHGEF12 MYH11 SEMA4D PLXNB1 MYH10 RHOA RHOC MYL12B ERBB2 RHOB ROCK1 MYH9 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 C3-1 CFB LOC110384692;C4A;C4B_2;C4B C2 C5 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells CBL MET CTNND1 CBLL1 EPS15 SH3GL2 SRC CTNNB1 SH3KBP1 RPS27A HGS UBB;UBC CDH1 SH3GL3 STAM SH3GL1 STAM2 UBA52 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism PDK4 MKLN1 LDHA RANBP9 PDHB MAEA GSTZ1 RMND5B RMND5A SIRT4 UBA52 DLD DLAT PDPR PDK3 RPS27A WDR26 PDK2 GID4 PDK1 GID8 UBB;UBC PDHX ME1 ARMC8 PDHA1 NEK1 PDP1 PDP2 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane SMO INPP5E CCT8 CCT5 CCT4 HDAC6 ARF4-1 CYS1 LZTFL1 UNC119B ARL6 ARL3 MCHR1 NPHP3 ARL13B RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 PKD2 PKD1 BBS9 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 RAB8A EXOC7 SSTR3 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 PDE6D RHO GBF1 RAB11A ATAT1 TTC8 CCT3 CCT2 TCP1 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions RUNX1 OCLN-1 TJP1 CLDN5 CBFB CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance LDLRAP1 LDLR APOE APOB LIPC PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import DDO SLC27A2 PAOX PHYH-4 PECR PEX10 PEX2 HMGCL PEX12 PEX13 PEX26 PEX14 ACOX2 ACOX3 IDE SCP2 PIPOX GSTK1 CROT DHRS4 HACL1 ACOX1 TYSND1 HSD17B4 CAT ACOT8 ACOT2;ACOT1 ECH1 AGXT HAO1 ACAA1-1 NUDT7 ACOT4 ZFAND6 UBE2D3-1 MPV17 USP9X PEX1 EHHADH-1 PEX7 PEX6 GNPAT NOS2 EPHX2 IDH1 AGPS UBE2D3;UBE2D2 UBA52 UBE2D1 AMACR LONP2 DAO BAAT RPS27A UBB;UBC CRAT NUDT19 DECR2 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT8 CNOT9 BTG2 NPM1-2 CNOT10 CNOT4 CNOT6 TNKS1BP1 TP53 RGCC CNOT7 CNOT6L CNOT11 PLK2 CNOT1 CNOT2 PLK3 CNOT3 CENPJ CDC25C PLAGL1 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) VAMP2 VAMP1 SV2C SV2B SV2A TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation AP2A2 ATP6V1H LCK AP2S1 CD4 ARF1 AP2A1 AP2B1 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 MET STAT3 HGF BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs ALOX12 PTGS2-2 ALOX5 ALOX15 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation SPR PRKG2 CALM3;CALM1 PTS GCHFR NOS3 DHFR2;DHFR GCH1 HSP90AA1 AKT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes CDK1 NCAPH2 NCAPG2 CCNB1 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ NCAPD3 SET-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MCPH1 SMC4 H2AC4 SMC2 RB1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KMT5A PLK1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis P4HB IHH PSMD12 PSMD11 ADAM17 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 SHH PSMB4 PSMD7 ERLEC1 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 HHAT PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 DHH GPC5 UBA52 DISP2 SCUBE2 NOTUM VCP-1 RPS27A SYVN1 DERL2 UBB;UBC OS9 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 ADAM17 DLL1 JAG2 DLL4 JAG1 ADAM10 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 RPA3 POLD2 RFC5 RFC3 LIG1 RFC4 FEN1 RFC2 RFC1 POLD1 PCNA SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes HOXC4 DPF1 DPF2 EAF1 DPF3 EAF2 SMARCC1 SMARCC2 RELB CTDP1 APEX2 PAXIP1 TAF9 POLR2A SUPT6H POLR2B ZBTB17 POLR2C CREBBP POLR2D AFF4 SS18L1 POLI POLR2G POLH TAF9B IRF8 POLR2I SMARCA2 SMARCA4 STAT6 MLLT1 TAF15 MLLT3 IWS1 TAF12 NFKB2 TAF13 TAF10 MCM3AP TAF11 SSRP1 TAF8 TCEA1 TAF7 ASH2L BATF TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SS18 NCOA6 ACTL6A MAFK CDC73 PAX5 LEO1 MYB PCNA UBA52 DIS3 PMS2 MLH1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 UBB;UBC EXOSC1 REV1 CTNNBL1 MAD2L2 REV3L KMT2D KMT2C MSH2 STAT3 CTR9 RTF1 ACTB-1 PAF1 BCL6 DPY30 PAGR1 BCL7A BCL7C BCL7B WDR5 EXOSC10 EXO1 KDM6A TBP C1D MPHOSPH6 ARID1A ARID1B RFC5 RFC3 RFC4 RFC2 MSH6 SMARCD1 CEBPA SMARCD2 JUND SMARCD3 E2F7 E2F8 E2F2 CCNK CCNT1 RBBP5 FOSB SUPT16H POLR2E AICDA POLR2F GTF2F1 POLR2H GTF2F2 POLR2L SMARCE1 RFC1 SUPT4H1-1 RELA SUPT5H CDK9 POLD3 POLR2J;POLR2J2;POLR2J3 CCNT2-1 POLD2 E2F5 TAF4B NFKB1 ELL ELOC-1 WDR61 TAF7L ELOA MEF2B;BORCS8-MEF2B NELFB SMARCB1 ELOB NELFCD NELFA NELFE BACH2 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis PPP1R3C UGP2 RPS27A EPM2A UBB;UBC GBE1 PGM1 GYG2 GYG1 GYS2 GYS1 NHLRC1 UBA52 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins SLC25A4 NUP133 NUP107 NUP188 NUP50 POM121;POM121C BANF1 NUP54 KPNA1 NUP210 NUP93 PSIP1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 SLC25A5 NUP62 SLC25A6 NUP37 NDC1 SEC13 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis CDKN1A STAT3 CEBPE GFI1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBFB TAL1 RUNX1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 DEK H2BC15;H2BC3;H2BC11;H2BC12 IL6R H2BC5 MYB H2BC21 H2BC1 CEBPB LEF1 RXRA CDK4 H2AC20 KLF5 CDK2 RARA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 FLI1 H2AC4 TFDP1 GATA2 TFDP2 CEBPA CSF3R KMT2A MYC E2F1 SPI1 H2AC14 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking DNM2 WASL NOSTRIN CAV1 NOS3 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GLB1L2 GNS GLB1L GLB1 OMD GALNS ACAN FMOD LUM PRELP KERA HEXB HEXA GLB1L3 OGN EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle XRCC6 XRCC4 XRCC5 BANF1 KPNA1 LIG1 PPIA LIG4 FEN1 PSIP1 CXCR4 CD4 CCR5 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle CANX UBA52 PRKCSH EDEM2 CALR-1 EDEM3 RPS27A AMFR SYVN1 DERL2 EDEM1-1 RNF5 UBB;UBC RNF103 MAN1B1 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 SEL1L GANAB PDIA3 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense SFN GBP2;GBP3;GBP1 PIM1 CASP1 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism PTGIS PLA2G4A HPGDS PON3 PTGES3-1 HPGD PON2 PON1 LTC4S ALOX15B TBXAS1 ALOX5AP CYP1B1 CYP4F22 LTA4H PRXL2B CYP2J2-1 PTGES2 ALOX12B GPX1 CYP8B1 GPX4 FAAH2 CBR1-1 AWAT1 GGT1 ALOX15 ALOX12 DPEP2 CYP2C9;CYP2C19 DPEP1 CYP4B1 EPHX2 ALOX5 ALOXE3 CYP1A1 CYP1A2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 FAAH GGT5 MAPKAPK2 PTGDS PTGS1 PTGS2-2 SLC27A1 PTGR1-1 CYP2U1 PTGES ABCC1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors CALCA RAMP1 ADM2 RAMP2 RAMP3 CALCB;CALCA CALCRL CALCR ADM IAPP REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions ITGB1 ITGB5 ITGB8 ITGA2 LUM ITGA10 ITGAV COL16A1 ITGB6 CDH1 BSG VCAM1 ITGB2 COL23A1 HSPG2 COL13A1 F11R FN1 ITGA8 PECAM1 COL9A1 COL9A3 COL9A2 COL18A1 COL4A2 COL4A1 COL4A4 THBS1 COL4A3 JAM2 KDR JAM3 TNC ITGA6 COMP CD47 IBSP VTN ITGB3 ITGA11 FBN1 ITGAE FGB ICAM3 ITGAL FGA ICAM4 CD44 ICAM5 ITGAX FGG ITGA1 ITGA2B ITGB7 ITGA4 ITGA3 ITGAD ITGA7 ITGA5 SPP1 AGRN ITGAM ITGA9 ICAM2 ICAM1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation C1S C1R C1QC C1QB CRP PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO RWDD3 SENP1 SUMO1 SENP5 SUMO3 UBE2I SUMO2 SENP2 UBA2 SAE1 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters SLC30A2 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC24A5 SLC39A7 SLC40A1 SLC39A2 SLC39A4 SLC39A1 SLC8A3 HEPH SLC39A3 SRI CALM3;CALM1 SLC8A1 SLC8A2 SLC30A10 SLC24A2 SLC24A3 SLC9A1 SLC8B1 SLC9A2 SLC24A1 SLC9A3 SLC24A4 SLC9A4 SLC30A8 SLC9A5 SLC30A5 CP SLC9A6 SLC9A7 SLC9A8 SLC31A1 SLC9A9 SLC41A2 SLC11A2 SLC41A1 SLC11A1 SLC30A3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L TBP BDP1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3C6-1 CRCP G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK GNB3 GNGT1 GNB5 GNG10 GNG2 GNG5 GNG4 BTK GNG8 GNG13 GNB2 GNB1 GNB4 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion APOBEC1 APOBEC2 A1CF CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle ESCO1 BUB1 FBXL18 ESCO2 CLASP2 AKT2 AKT3 CSNK2A1;CSNK2A3 PPP1CC GOLGA2 SFN CDC25A HMMR CDC25B PRIM2 PRIM1 POLA1 POLA2 RPS27 LPIN1 LPIN2 LPIN3 SKP2 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PPP1CB MAPRE1-1 PRKACA-1 ACTR1A TUBA1A LBR PPP2R1A CNTRL CEP250 NEK2 BTRC CEP290 YWHAG RAB8A SKP1 CDK5RAP2 HSP90AA1 OPTN-1 TERT HJURP CEP135 PPP1R12A RSF1 MIS18BP1 BORA OIP5 FBXW11 CENPW HAUS4 HAUS3 MIS18A CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 KIF20A CEP192 RPS27A PCNT CEP76 OBI1 LCMT1 CLASP1 UBB;UBC PPME1 CEP78 TICRR PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ RTEL1 ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 KIF18A ACD TINF2 ATRX TERF2 POT1 TERF2IP TERF1-1 IST1 SPAST CC2D1B DHFR2;DHFR JAK2 UBE2N KIF23 HSP90AB1 RAD51C TYMS KIF2A YWHAQ YWHAH KIF2C KIF2B CABLES1 CENPE WEE1 DKC1 NHP2 MAX LMNB1 NOP10 PPP2R2A;PPP2R2D TUBA1C TUBB1 E2F5 E2F6 TUBB2B;TUBB2A CCNE2 CCNE1 RB1 CCNH H2AC14 TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 CCND3 CCND2 KAT5 CHEK2 SMARCA5 CHEK1 CDKN2D DAXX CDKN2C HUS1 TUBA8 H2AC20 WRAP53 H2AB2;H2AB3;H2AB1 MYBL2 DNA2 RHNO1 PHF20 E2F4-1 TFDP1 PCBP4 TFDP2 RAB1A ATRIP RAB1B BARD1 PLK3 E2F1 CDC7 E2F3 TPX2 RAD17 ATM ATR CDKN1A CDKN1B BRCA1 H2AJ CDCA5 PDS5B PDS5A WAPL ESPL1 BABAM1 RMI2 BABAM2 FKBP6 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 CDKN2B H2BC5 PCNA WRN H2BC1 RPA1 PTK6 RPA2 CDK4 MLH1 CDK2 PTTG1;PTTG2 RPA3 EP300 PHLDA1 RAD1 H2AC4 CLSPN MRE11 KMT5A NBN CDK11A;CDK11B CDC25C CDK6 ABL1 BLM MDM2-2 NPM1-2 SPO11 SYCP1 CDK7 SYNE2 SYNE1 SUN1 TEX12 SMC1B MSH4 MNAT1 MSH5 DMC1 GSK3B SYCP3-2 KPNB1 RAD51 PSMC3IP SYCE2 SYCE1 MND1 HSPA2 MLH3 REC8 STAG3 SYCP2-1 MDM4 RAD9B H2BC21 RAD9A EXO1 H2AZ2;H2AZ1 TOPBP1 ZNF385A RFC5 RFC3 RFC4 RFC2 RBL2 RBL1 BIRC5 SMC3 AURKB RAD21 RBBP8 STAG1 HDAC1 STAG2 SMC1A RAD50 RBBP4 PRDM7;PRDM9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 POLR2L POLE RFC1 LIN54 LIN37 H2BC15;H2BC3;H2BC11;H2BC12 LIN9 LIN52 LYN GINS1 GINS2 CDC45 MCM7 NSD2 MCM8 GINS3 POLD3 GINS4 MCM3 POLD4 MCM4 POLD2 MCM5 MCM6 MCM2 POLE4 MAPK1 POLE2 RUVBL2 POLE3 RUVBL1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 C1orf112 PSMB6 BRCA2 PSMB7 PSMD6 PSMB4 PSMD7 FIGNL1 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 YWHAB XPO1 AKT1 TNPO1 NUP214 PRKCA YWHAZ ANKLE2 SET-1 MCM10 DBF4 MAPK14 MAPK11 PRKCB DYNC1LI1 DYNC1LI2 DSCC1 CHTF18 CTC1 RBX1 STN1 TEN1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 GTSE1 FKBPL CSNK1A1 NUF2 EMD NUDC INCENP CENPA CENPC E2F2 TP53BP1 CENPT TOP2A NUP107 CENPU NUP188 RCC1 BANF1 PPP6C NUP210 CENPF CENPH PPP6R3 RNF168-1 LIG1 GORASP1 CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A CENPL NUP205 USO1 CENPM NEK9 NEK6 AAAS NEK7 NEK11 CENPO ANKRD28 CENPP NUP160 NUP85 CENPQ TPR NUP88 PIF1 NUP155 SHQ1 SUN2 NUP153 POLR2J;POLR2J2;POLR2J3 CHMP2B CHMP2A RRM2-1 CLIP1 FEN1 MAD1L1 BRIP1 NUP62 CDKN1C NDC1 SEC13 NUP133 NDC80 RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 NUMA1 CHMP7 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 VPS4A TUBGCP4 POLR2A SPDL1 NUP42 POLR2B POLR2C POLR2D NUP43 POLR2G POLR2I RAE1 RANBP2 NSL1 CENPX NUP35 RAN NUP37 GMNN ORC5 COP1 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KNL1 ZW10 DSN1 EML4 RCC2 ZWINT CDC14A AHCTF1 HERC2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E FOXM1 VRK1 LEMD2 CTDNEP1 CNEP1R1 FBXL7 RAB2A GORASP2 BLZF1 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 PIAS4 UBE2I DYRK1A POLD1 CKS1B PPP2R3B B9D2 SPC24 SPC25 PKMYT1 ERCC6L ARPP19 NCAPH2 SUMO1 NCAPG2 ZWILCH NIPBL ENSA SIRT2 NCAPD3 PMF1;PMF1-BGLAP MAU2 MASTL MCPH1 TP53 KNTC1 SGO1 UBE2V2 SGO2 MYC CENPS-CORT;CORT;CENPS CSNK2A2 CCND1 CSNK2B ANAPC15 ANAPC16 TK1 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants NOTCH1 ADAM17 MIB2 DLL1 JAG2 DLL4 RPS27A NEURL1 UBB;UBC NEURL1B MIB1 JAG1 UBA52 ADAM10 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle BCR ARHGEF5 STOM DAAM1 IQGAP3 FMNL3 FMNL2 ABR STARD13 JUP CAVIN1 MCAM CAV1 MYO9B ACBD5-1 DLC1 ARHGAP1 TJP2 RTKN ROCK2 ARHGAP39 CIT IQGAP1 ARHGDIA VAMP3 PKN3 ARHGEF40 PIK3R1 ROCK1 LMAN1 ARHGAP5 ARHGAP21 ARHGEF25 FLOT2 ARHGEF28 STX5 LBR ARHGAP18 OPHN1 TMPO ARHGAP35 MCF2 VANGL1 RHOA DEPDC1B MACO1 ARHGAP26 DIAPH1 ARHGAP32 PKN2 VAPB PKN1 ANLN DIAPH3 ARHGEF10L AKAP13 C1QBP MCF2L STK10 FLOT1 SLK ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ARHGEF17 TFRC RHOC ERBIN VAV2 PREX1 CCDC187 ARHGEF1 RACGAP1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP FGF23 P4HB APOB APOL3;APOL4;APOL1;APOL2 MSLN BPIFB2 SDC2 MFGE8 CST3 APP DNAJC3-1 IGFBP7 WFS1 PNPLA2 ALB DMP1 CALU ANO8 VCAN MATN3 SPP2 MELTF AHSG PDIA6 TNC APLP2 APOA2 APOA1 SCG3 CKAP4 KTN1 APOA5 LOC110384692;C4A;C4B_2;C4B FBN1 GPC3 CP KLK13 CSF1 IGFBP1 LAMB2 MEN1 LTBP1 IGFBP3 HSP90B1 TF CHRDL1 PENK QSOX1 MBTPS1 MIA3 FSTL1 FSTL3 ADAM10 IGF2 PRKCSH MGAT4A-1 GZMH-1 BMP4 FN1 IGF1 LAMC1 C3-1 KLK3;KLK2 CTSG TIMP1 LGALS1 AMELY;AMELX SERPINA1 EVA1A CCN1 CHGB IGFBP5 MMP1 IGFBP4 MMP2 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 IGFBP6 AMBN TMEM132A HRC FGA PRSS23 BMP15-1 FGG MEPE F2 RCN1 ENAM NOTUM F5 AMTN VWA1 FAM20C PLG FAM20A PAPPA2 ITIH2 SERPINC1 AFP SPP1 KNG1 GOLM1 VGF SERPIND1 NUCB1 LAMB1 FUCA2 TGOLN2 PROC CDH2 IL6 APOE PCSK9 GAS6 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina CDK1 PRKCA EMD CCNB1 LEMD3 LPIN1 LPIN2 LPIN3 LMNB1 LEMD2 CTDNEP1 CNEP1R1 PRKCB XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics ARNT2 AHRR AHR CYP2C18-1 CYP2S1 CYP2D6;LOC107987479;LOC107987478-1 CYP2F1 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP2J2-1 CYP1A1 CYP1A2 ARNT CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP2W1 CYP2B6 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD DLD BCKDHA PPM1K DBT BCKDHB NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus NGF PSEN1 RPS27A PSENEN NCSTN PSEN2 TRAF6 UBB;UBC APH1A APH1B NGFR SQSTM1 ITGB3BP MAPK8 UBA52 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB-1 HADHA HADH ACADM ECHS1 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B ABCA12 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) MVD HELZ2 MED1 MVK HMGCS1-1 TM7SF2 MBTPS1 SCAP MBTPS2 KPNB1 SAR1B TGS1 CREBBP SP1 PMVK INSIG2 INSIG1 SREBF2 RXRA GPAM CARM1 PPARA NFYA-1 DHCR7 RAN SEC23A NFYB NFYC NCOA1 NCOA2 NCOA6 SMARCD3 SEC24B SEC24A GGPS1 SEC24C IDI1 FDFT1 SQLE ACACB ACACA CYP51A1 ELOVL6 SCD FDPS SEC24D-1 MTF1 CHD9 TBL1XR1 FASN LSS SC5D FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome APAF1 UACA AVEN DIABLO-1 CASP9 MAPK1 MAPK3 CYCS-1 APIP XIAP PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors PFKFB1 PRKACB-1 PRKACA-1 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis GSK3A TRIM27 MAPK1 CTSG MAPK3 SFPQ-1 RNF213-2 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein GSK3A PARP9 SUMO1 SRPK2 PARP8 PARP16 PARP14 SRPK1 PARP10 GSK3B UBE2I PARP6 PARP4 PRMT1 CSNK1A1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) FEN1 RAD52 RAD50 POLQ MRE11 PARP2 NBN LIG3 BRCA2 RBBP8 XRCC1 PARP1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 TGFB1 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair MSH2 BLM RAD51 RAD9B KAT5 RAD51B RAD9A NEIL3 RAD51C NEIL1 HUS1 EXO1 NTHL1 BRCA2 TOPBP1 DNA2 RAD51AP1 RHNO1 RFC5 RFC3 RFC4 XRCC2 RFC2 PALB2 ATRIP MSH6 MSH3 BARD1 RBBP8 OGG1 SEM1 RAD17 ATM RAD50 ATR BRCA1 RMI2 RMI1 TOP3A RAD51D WRN PMS2 RPA1 RPA2 MLH1 RPA3 RAD1 BRIP1 MRE11 NBN REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion CSNK2A1;CSNK2A3 MOGS H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A RPN2 SEC11C RPN1 PSMD12 PSMD11 PSMD14 PSMD13 SMARCA4 FOXA2 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 SRC EZH2 PSMB6 TGIF2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 SPCS3 PSMD3 ANK3 SPCS2 PSMB1 SPCS1 PSMD1 BANP ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 SIRT1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 H2AJ TCF12 ADAM33 CANX CDH8 PCSK6 TLE1 ADAM19 ANGPTL4 CDH24 SUZ12 H2BC5 UBA52 H2BC1 SOX10 KDM1A CDH19 DNM2 MPHOSPH8 PRDM8 HEYL ILF3 FOXF1 BHLHE22 HOXC8 RPS27A H2AC4 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 MDM2-2 SNAI1 SNAI2 CTNNA1 CDH1 KLF4 OST4 JUP STRAP OSTC STT3A TWIST2 SP1 H2BC21 VCL PRKCSH EED DDOST H2AZ2;H2AZ1 WT1 ARID1A DAD1 GANAB MYC CTSS HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B CTSB CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 FURIN ZMYM2 CTBP2 CTBP1 MAPK1 POMT2 RB1 MAPK3 POMT1 H2AC14 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation ITPR1 PRKCD ITPR2 PRKCA ITPR3 KDR PDPK1 PRKCZ AHCYL1 CALM3;CALM1 SPHK1 PLCG1 HRAS RASA1 PRKCB NRAS SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 ITGA2B ITGB1 CSNK2A2 ITGA5 L1CAM PAK1 RAC1 CSNK2A1;CSNK2A3 ITGAV CSNK2B MAP2K2;MAP2K1 ITGA9 NRP1 EGFR VAV2 MAPK1 ITGB3 MAPK3 NCAM1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35D1 SLC35B3 SLC35D2 SLC35B2 SLC35B4 SLC35A1 SLC35A2 SLC35A3 SLC35C1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance SOAT1 SOAT2 NR1H3 NPC2 APOC1 APOC4 APOB APOA1 LIPC VLDLR NR1H2 CLTC CLTA AP2A1 UBA52 AP2B1 AP2A2 LDLRAP1 AP2S1 MYLIP RPS27A CES3 CUBN APOBR UBB;UBC LDLR APOE PCSK9 HDLBP LSR LIPA AMN NCEH1 NPC1-1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG DAGLA ABHD6 ABHD12 DAGLB MGLL METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A8 S100A7A;S100A7 LTF LCN2 S100A9 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism MAN2B2 MAN2B1 MANBA MAN2C1 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions CYP2S1 CYP2D6;LOC107987479;LOC107987478-1 CYP2F1 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 CYP2B6 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) GUSB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis DPM1 DPM2 MVD DPM3 ST8SIA5 ST6GAL1 CTSA MPI ST3GAL4 ST6GALNAC2 DOLK ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 SRD5A3 SLC35C1 ST6GALNAC1 CMAS NPL NANP ST6GALNAC3 ST6GALNAC4 NEU4 NAGK AMDHD2 ST8SIA4 NANS GFPT2 ST6GAL2 GFPT1 PGM3 ST8SIA1 GNPNAT1 GNE UAP1 RENBP ST3GAL6 ST6GALNAC5 GLB1 ST6GALNAC6 ST3GAL5 ALG5 NUDT14 DHDDS PMM2 GMPPB FPGT GMPPA GFUS DHRSX GMDS ST8SIA6 NUS1 PMM1 ST8SIA2 FCSK DOLPP1 ST8SIA3 HK1 NEU2 NEU3 SLC17A5 NEU1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 KLB FGF19 FGFR4 HRAS FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB NGF MYD88 RELA IRAK1 RPS27A PRKCI TRAF6 NFKB1 UBB;UBC IKBKB NGFR SQSTM1 RIPK2 NFKBIA UBA52 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases PTK2B AKT2 AKT3 PDE3B IDE PTPRF PIK3R4 STAT6 STAT5A STAT5B RAB4A EGF ERBB2 PLCG1 ADORA2A NRP1 EGFR PDGFRA TIAL1 FGF6 PTBP1 RBFOX2 ESRP2 RAP1B HNRNPH1 ESRP1 PRKACA-1 HGF HNRNPA1-1 DOCK7 TIA1 GAB1 HNRNPM MET PPP2R1A CTNND1 AREG EPS15 PRKCE HSP90AA1 FGF7 FGFBP1 FGFBP3 PCSK6 FGF22 FGF3 FGF10 UBA52 STAT1 ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MEF2A MEF2C MAPKAPK3 TNS4 TNS3 SPINT1 HPN MST1 MST1R SPINT2 STAT3 ITGA2 DOCK3 GRIN2B INS;INS-IGF2 CAV1 MEMO1 JAK2 FLT3 TAB2 ADAM10 ADAM17 PDPK1 PSEN1 NCSTN CDC42 PIK3C3 SH2B3 SH2B2 COL9A1 COL9A3 COL9A2 PLAT LAMC2 LAMC1 PTPN11 CTSD PTPRJ HGS CALM3;CALM1 ATP6V1H MMP9 PAK2 LAMA5 GABRB3 THBS4 GABRB2 LAMA3 THBS3 PDGFD GABRB1 FURIN RALA-1 PLG HNRNPF SPP1 YAP1-1 LAMB3 CMA1 LAMB1 GABRG3;GABRG2 SPHK1 FLT4 STUB1 GABRQ TGFA GABRA1 NOS3 YES1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 VEGFA SHC2 RALGDS PTPRO ATF2 RALB MAPK13 RIT1 SGK1-1 RIT2 CHEK1 CDH5 MAPKAP1 JUNB ARF6 GGA3 VEGFB VEGFC VEGFD MAPK7 MAP2K5 RAC1 TCF12 NRG1 NCOR1 NRG2 RHOA EREG BTC NRG3 NRG4 ELMO1 ELMO2 CRK FOS DOCK1 HBEGF WWP1 PXN CBL RICTOR NTF3 PTPN1 PTK6 ID1 BCAR1 EP300 GFAP PSEN2 APH1A APH1B DNMT1 ADCYAP1 ADCYAP1R1 FLRT2 FLRT3 FLRT1 ITGAV CDK5 PSENEN CHD4 SIN3A PGF FLT1 SHB THEM4 PRR5 MLST8 SOCS6 JUND HDAC2 HDAC3 THBS1 CXCL12 HDAC1 MTOR BAX FOSB PCSK5 POLR2E POLR2F POLR2H SHC1-1 POLR2L ITGB3 LYN HGFAC NTRK2 TIAM1 BDNF CDK5R1 F3 AHCYL1 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 BRAF MAPK3 CRKL FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 INSR GRB10 PIK3R3 COL4A5 THBS2 GALNT3 MUC20 REST RANBP10 ROCK1 PTPRK EPS15L1 EPN1 COL4A2 ADAM12 COL4A1 LRIG1 COL4A4 FAM83D TEC AAMP COL6A2 PAG1 COL4A3 FAM83B FAM83A COL6A1 SPRY1 PTPN3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 COL6A3 CTNNB1 COL6A6 IRS4 COL6A5 RAB4B ATP6V0D1 ATP6V0D2 YWHAB ATP6V1A HSPB1 KIT NTRK3 AKT1 ATP6V0A2 PRKCD ATP6V0A4 PRKCA ATP6V1D MAPKAPK2 ATP6V1C1 ATP6V1F ATP6V0A1 CYFIP2 ATP6V1C2 CYFIP1 NCKAP1 WASF1-1 MAPK14 MAPK11 TCIRG1 PRKCB ATP6V0B MEF2D FLT3LG PDGFB PTPN2 ATP6V1B2 EGR1 ATP6V0C ATP6V1B1 ANOS1-1 GRAP2 GAB2 PRKCZ KLB NCKAP1L PDGFRB LTK JUP TNK2 FGF19 ATP6V1G3 FGFR4 PRKACB-1 ATP6V0E2;ATP6V0E1 ITCH IGF1 SPRED2 CILP CSN2-1 SPRED1 GRAP HRAS FYN RASA1 MXD4 PTPRU MKNK1 STMN1 SPRY2 NRAS ADAP1 FER KDR KIDINS220 TLR9 ABI2 GTF2F1 GTF2F2 GRB2 TGFBR3 GIPC1 ABI1 IGF1R EPGN NCF1 NCF2 NCF4 POLR2J;POLR2J2;POLR2J3 SHC3 TRIB3 FES NELFB APOE MAPK12 USP8 PTPN18 NCBP1 MATK NRP2 NCK2 POLR2A IRS2 NCK1 POLR2B POLR2C POLR2D SOCS1 POLR2G ITPR1 POLR2I ITPR2 LCK ITPR3 ROCK2 SRC SRF NCBP2-1 LAMA1 CSK SPARC WASF2 WASF3 BAIAP2 PTPRS GRB7 STAM LAMC3 NTRK1 CLTC PTK2 CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 ITGA3 DNM3 AP2S1 DNAL4 SH3GL2 PPP2CB;PPP2CA LAMA2 LAMA4 LAMB2 VAV3 PPP2R5D PPP2R1B CDC37 ERBIN VAV1 VAV2 ARHGEF7 ITGB1 PAK1 FGF2 CTNNA1 PAK3 NEDD4 FGFRL1 SH3GL3 SH3GL1 ESR1 IGF2 PGR ID4 ALK CD274 IRS1 PIK3R2 PIK3CB PTN PRDM1 CYBB RNF41 PIK3R1 CYBA IL2RG HIF1A PTPRZ1 CUL5 MDK MYC STAM2 ALKAL2 ALKAL1 TPH1 JAK3 FRS2 MYCN PIK3CA PTPN6 RANBP9 DIAPH1 WWOX DLG4 PTPN12 NAB1 NAB2 LYL1 ARC SH3KBP1 ATP6AP1 VGF TRIB1 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 ID3 CDK5R2 ID2-1 AXL SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET USP8 SPINT1 SOS1 HPN SPINT2 PTPN2 ITGB1 STAT3 ITGA2 SH3GL3 SH3GL1 MUC20 RAB4A SRC RANBP10 LAMA1 ARF6 HRAS PIK3R1 LAMC2 LAMC1 STAM2 GGA3 RAP1B NRAS LRIG1 HGF DOCK7 GAB1 PIK3CA MET PTPN11 EPS15 RANBP9 RAC1 PTPRJ HGS RAB4B CRK LAMC3 STAM HGFAC PTK2 UBA52 CBL LAMA5 ITGA3 LAMA3 PTPN1 SH3GL2 LAMA2 LAMA4 SH3KBP1 LAMB3 LAMB2 RPS27A LAMB1 UBB;UBC RAP1A RAPGEF1 CRKL TNS4 TNS3 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane STX5 VAMP2 STX1A APP EMD HMOX1 UBL4A CAMLG SGTA BAG6 GET1 GET3 SEC61G GET4 SEC61B OTOF VAPA PRNP AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC TP53 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion PDCD6IP VPS37C VPS37D VPS37A VPS37B CHMP3 CHMP6 CHMP7 CHMP5 VPS4B CHMP4C VPS4A CHMP4B CHMP4A VPS28 TSG101 NEDD4L MVB12B MVB12A UBA52 VTA1 CHMP2B RPS27A CHMP2A PPIA UBAP1 UBB;UBC UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CCND1 GSK3B UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 CDK4 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 KAT5 ATM RAD51B RAD50 RAD51C BLM EXO1 BRCA1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 RMI2 BRIP1 RAD51 MRE11 RMI1 TOP3A BARD1 NBN RAD51D RBBP8 WRN REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA13 CA5B CA12 CA1 CA5A CA3 CA2 CA4 CA7 CA6 CA9 CA14 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes MSH2 POLH PMS2 MLH1 EXO1 POLD3 POLD2 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC REV1 RFC1 MAD2L2 MSH6 REV3L PCNA UBA52 POLI OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence CDK6 MAPKAPK5 MINK1 TXN MDM2-2 MAP2K6 BMI1 KDM6B RING1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDM4 H2BC21 RNF2 CDKN2D CDKN2C CBX8 H2AC20 TNIK CBX6 EED PHC2 H2AB2;H2AB3;H2AB1 PHC1 H2AZ2;H2AZ1 EZH2 CBX4 CBX2 PHC3 TP53 TFDP1 TFDP2 E2F1 E2F3 IFNB1-4 E2F2 JUN MAP4K4 TNRC6C MOV10 TNRC6A-1 RBBP4 AGO4 AGO3;AGO1 H2AJ TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 FOS H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 CDKN2B H2BC5 UBA52 H2BC1 MAPKAPK2 CDK4 RPS27A CDKN2A MAP3K5 H2AC4 UBB;UBC MAP2K3 MAPK1 MAPK14 MAP2K4 MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 H2AC14 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins CCNT1 CDK9 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription NOTCH1 HES1 STAT1 SNW1 PLXND1 MAMLD1 RBPJ FABP7 WWC1 PBX1 KAT2B HEYL DLGAP5 PTCRA KAT2A MAML2 EP300 MAML1 HES5 MAML3 NOTCH3 HEY1 CREBBP HEY2 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria TP53 TFDP1 TFDP2 PMAIP1 E2F1 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1-1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TICAM2 LY96 TICAM1 RPS27A IRAK2 TRAF6 CD14 UBB;UBC MAP3K7 TLR4 TAB3 TAB2 UBA52 TAB1 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway PTK2B AKT2 NOS3 AKT3 PAK1 ITGAV PRKCZ CTNNA1 PAK3 NCKAP1L JUP NCK2 CAV1 NCK1 SHC2 PRKACB-1 MAPK13 SHB ITPR1 THEM4 ITPR2 PRR5 ITPR3 CDH5 PDPK1 ROCK2 MLST8 CDC42 MAPKAP1 PIK3R2 PIK3CB PLCG1 HRAS CYBB CYBA PIK3R1 RASA1 FYN WASF2 WASF3 ROCK1 NRAS BAIAP2 PRKACA-1 PIK3CA CTNND1 MTOR KDR CTNNB1 RAC1 HSP90AA1 RHOA ABI2 CALM3;CALM1 ELMO1 ABI1 ITGB3 ELMO2 CRK HSPB1 DOCK1 PTK2 AKT1 PAK2 PXN NCF1 PRKCD RICTOR PRKCA NCF2 NCF4 MAPKAPK2 BCAR1 CYFIP2 CYFIP1 NCKAP1 VAV3 TRIB3 WASF1-1 AHCYL1 SPHK1 VAV1 VAV2 MAPK14 MAPK11 MAPKAPK3 MAPK12 AXL PRKCB DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 PRELP ST3GAL3 OMD ACAN KERA FMOD LUM OGN COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation CTSK CTSD CTSB COL16A1 CTSV;CTSL MMP7 COL12A1 COL25A1 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP12 MMP11 MMP14 MMP13 MMP15 PHYKPL COL23A1 MMP19 ADAM10 COL15A1 ADAM17 TMPRSS6 FURIN ADAM9 COL17A1 COL19A1 COL13A1 COL26A1 PRSS3;PRSS2;PRSS1 ELANE COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 MMP20 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex DLD PDK4 DLAT PDPR PDK3 PDK2 PDHB PDK1 PDHX GSTZ1 PDHA1 SIRT4 PDP1 PDP2 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle SLC25A20 THRSP CPT1A MID1IP1 PPARD RXRA CPT1B PRKAB2 PRKAA2 PRKAG2 SLC22A5 CPT2 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin HSP90AB1 HBEGF HSP90AA1 CD9 EEF2 TXNRD1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade FGF20 FRS2 GAB1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 PIK3R4 THEM4 PDPK1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB PIK3R1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events RBP4 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 EIF3C;EIF3CL RPL31 EIF1AY;EIF1AX RPL34 EIF3M RPL27A EIF3K RPL8 EIF3L EIF3I RPL9 EIF3J RPL6 EIF3G EIF3H RPL7 EIF3E EIF3F RPS4X EIF3D EIF3A RPL35 EIF3B RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling INHA TGFBR3 INHBA ACVR2A TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 APP NFKB2 TRAF6 TLR5 TP53 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER S100A12 N4BP1 JUN PPP2R1A USP18;USP41 MYD88 MAPK7 NFKBIB SAA2;SAA1 NKIRAS1 BTRC NKIRAS2 IKBIP IRAK4 ECSIT SKP1 TRAF2 PELI1 CHUK CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 FBXW11 TIFA HMGB1-1 MAP3K1 IKBKB IKBKG FOS UBA52 NFKBIA CUL1 MAPKAPK2 RELA TLR10 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA1-1 PPA2 LHPP RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H SSB NFIX POLR2L NFIA NFIB NFIC ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants CPSF6 BCR STAT1 PIK3CA CEP43 MYO18A LRRFIP1 STAT5A STAT3 FGFR1OP2 STAT5B TRIM24 GAB2 ZMYM2 PIK3R1 CUX1 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing PABPN1-1 CPSF4 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD MAT1A VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways DPM1 DPM2 DPM3 DNAJC10 ELAVL2 GBP2;GBP3;GBP1 CSNK2A1;CSNK2A3 RPL10A S1PR1 PPP1CC VIM RAB5A EGFR RPL36AL-1 YWHAE PPP1CB PRKG2 NEK2 BTRC YWHAG APOA1 SKP1 HSP90AA1 CDC73 LEO1 UBA52 DYNC1I2 RPL18A RPS27A ELK1 UBB;UBC DYNC1H1 TUBB4A;TUBB;TUBB8B;TUBB8 BCL2L1 HSPG2 ACOT2;ACOT1 COMT RPL15-1 CTSV;CTSL MMP9 ITGA4 FURIN RB1 CCNH H2AC14 TRIM28 MED1 MED4 MED6 MED7 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SMAD2;SMAD3 H2AC20 EZH2 RPL10;RPL10L-1 MED16 MED17 MED12 MED14 MED13 MED10 MED27 ARF1 MED23 RPLP0 NCOR2 NCOR1 RPLP2 MED24 TAL1 RPL36-1 MED20 GPS2 SF3B1 MBD3 SUZ12 H2BC5 H2BC1 GTF2H1 GTF2H3 GTF2H4 GATAD2B GATAD2A MED31-1 ARID4B EP300 NRBP1 H2AC4 SAP30 TBL1XR1 MED30 SUDS3 RPL22L1 CDK8 CDK7 RPL37A-1 MNAT1 GSK3B KPNB1 PSIP1 CHD4 CHD3 H2BC21 PARP1 TBP EED SMAD4 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CAMK2B CAMK2D HDAC2 CAMK2A RPL13A-1 HDAC3 SLC25A4 HDAC1 CAMK2G MTA1 RBBP4 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L PROS1 H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 F2 CLU RPL23A EIF2AK2 TLR1 TLR2 CD4 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 IPO5 GRSF1 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 IFIT1 IFIT3 ADRM1 IFIT2 VPS36 SNF8 VPS25 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 ATP1B2 ATP1B1 YWHAB HSPA1A;HSPA1B ELAVL1 XPO1 AKT1 NUP214 YWHAZ XRN1 FXYD4 FXYD3 FXYD1 HSPA8 PABPC1;PABPC3 FXYD6 EIF4G1 RBX1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 RPL26L1 RPL4 RPL30 RPL3 RPL32 ATP1B3-1 RPL31 FXYD2;FXYD6-FXYD2 RPL34 CSNK1A1 RPL8 RPL9 RPL6 ITCH RPL7 RPL35 RPL38 FKBP1A RPL39 CYSLTR1 SYK RPL21 HCK RPL23 RPL22 MED8 FYN MED9 CUL3 RPL24 RPL27 RPL26 RPL29 RPL28 NFKBIB CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 PLCG2 BANF1 TLR9 KPNA1 SUPT16H NUP210 CDK19 LIG1 LIG4 RPL3L GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L RPLP1-2 AAAS GTF2E1 GTF2E2 NUP160 NUP85 CLINT1 TPR NUP88 AP1G1 SUPT4H1-1 XRCC6 AP1S2 NUP155 AP1S1 XRCC4 AP1S3 XRCC5 VTA1 NUP153 AP1B1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 RAB5C CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 RPL11 ELOA RPL14 AP1M2 NELFB ELOB RPL13 NELFCD RPL18 AP1M1 NELFA RPL17 CCR5 RPL19 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 RPL7A CHUK UBA7 HSPA5 DDX58 ISG15 RPL35A UBE2L6 HERC5 IFIH1 IKBKB IMPDH1 TRIM25 IMPDH2 ARIH1 IKBKG CLTC CLTA AP2A1 AP2B1 KEAP1 AP2A2 AP2S1 ATG7 ITGB1 SCAP PIK3R1 CUL5 UBA6 UBA5 JAK3 UBR4 PTPN6 TGFB1 RUNX1 UBA3 UBA1 RELA NFKB1 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN RIPK3 ST3GAL1 ST3GAL2 ST3GAL3 VPS16 SRPK2 MLKL EDEM2 PARP16 PYCARD PARP14 SRPK1 PARP10 RPS25 RPS27 CASP1 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE JAK1 TOMM70 PARP6 PTBP1 PARP4 PRMT1 RIPK2 SFTPD HNRNPH1 ANO8 ANO9 HNRNPA1-1 ANO6 HNRNPM TYK2 ANO4 PARP9 IL17RC NFE2L2 ANO5 ANO2 PARP8 IL17RA ANO3 ANO1 EEF1A1 SIKE1 SMN2;SMN1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 GPC4 RPS2 MGAT2 GPC6 STAT1 KDM1A STAT2 SEC24D-1 MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 RPS9 RPS7 RPS8 RPS5 VPS33A PHF21A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU RCOR1 IFNAR1 SNRPB DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG HMG20B CAV1 MAVS OSTC STT3A JAK2 UBE2N TAB3 TAB2 STT3B TAB1 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 IRF3 DOCK2 DAD1 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB EIF4A2 SNRPG-2 EIF4A1 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 MGAT4B VPS45 SEC24C EIF4E ATP6V1H PABPN1-1 PAK2 HNRNPF HNRNPA2B1 SNRPA1 DAXX MAPKAP1 SNW1 RAC1 RPTOR EXOC1 ELMO1 GBF1 RICTOR NPLOC4 UFD1 FASN U2AF1L5;U2AF1 EIF4A3 NPM1-2 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 PRR5 DHX38 SRSF11 SRSF4-1 ALYREF MLST8 RNPS1 CBX1 FKBP4 PML MTOR TLR3 LY96 RIPK1 CD14 TLR4 LYN NFKBIA H2AC16;H2AC11 ARID4A SOS1 BRMS1 IFNGR1 IFNGR2 P4HB H2BC18 REST SLC25A5 SLC25A6 ROCK1 MED19 MED15 MED18 MED11 PPIB MED26 MED29 MED22 MED25 MED21 P4HA1 RBMX P4HA2 P4HA3 RPL12-1 DYNC1LI1 DYNC1LI2 CD28 HNRNPC SP1 KPNA4-1 HYOU1 CPSF2-1 ATL2 CRBN NUDT21 FNTA LY6E FUS NACA BCAS2 C1S HNRNPA0 HNRNPA3 GPKOW CDC5L PDCD1 DHX9 BST2 TAOK1 SUGP1 PEX19 IGF1R IL6R DNAJB11 PPIE PPIH PPIG CD8B;CD8B2 SUN2 HNRNPU HNRNPR MAP1B WDR61 BTF3 HNRNPL HNRNPK HNRNPD WDR33 GAS6 ISY1;ISY1-RAB43 MED13L PHF5A AUP1 IPO7 PAPOLA TXNL4A SNRPN RAB5B NCL-1 PLRG1 DNAJC8 CEBPD CD33-1 FIP1L1 SEC11A NCK1 SEC11C SNRNP40 DNAJA2 PPIL3 PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 LCK CSTF3 CSTF2 CD79B ROCK2 CD79A CHMP1A HNRNPH2 TLR6 EMC4 SPCS3 SPCS2 SPCS1 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 CPSF4 CPSF1 CPSF3 CWC15 FNTB;CHURC1-FNTB CGAS BLNK BTK RBM5 C4BPA C4BPB CLDN1 LOC110384692;C4A;C4B_2;C4B GRPEL1 PQBP1 SRRT CALR-1 KPNA7 KPNA5 KPNA3 SNRNP200 VAV1 CTNNBL1 SIGMAR1 PRCC MERTK KDELR1 CCAR1 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 PAF1 DYNC1I1 RETREG1 DHX15 DHX16 BCAP31 UBE2I ZBP1 NR3C1 WBP11 HNRNPUL1 RTN3 DDX46 DDX42 SUMO1 RBM17 DYNLT1 BUD31 RBM22 DDX23 CSTF2T RRBP1 PPIA SMNDC1 U2SURP CLP1 TYRO3 MRC1 SF3B4 SF3B5 CSNK2A2 SF3B2 SF3B3 SF3B6 BRD4 DDX3X-1 SF3A3 SF3A1 SF3A2 XAB2 CSNK2B CPSF7 CLEC5A RPL5-1 VTN BAG2 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 CX3CR1 CLEC4M;CD209-2 PUF60 SNRPB2 AQR NMI SH3KBP1 PRPF19 MED28-1 PCF11 PACS1 MAPRE3 AXL HDLBP EFTUD2 PDIA3 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM MMAA MMUT POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation TDGF1 SALL4 SALL1 DPPA4 STAT3 POU5F1;POU5F1B EPHA1 SOX2 FOXD3 NANOG;NANOGP8 FGF2 ZIC3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PSMD12 MGME1 PSMD11 RNASEH1-1 PSMD14 EXOG PSMD13 POLG PRIM2 PRIM1 H2AC20 PSMA7 POLA1 PSMD8 POLA2 H2AB2;H2AB3;H2AB1 PSMB6 DNA2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 H2AJ TOP3A H2BC5 PCNA UBA52 H2BC1 CUL1 RPA1 RPA2 CDK2 RPA3 RPS27A H2AC4 UBB;UBC KPNA6 MCM10 DBF4 RBX1 POLRMT POLG2 KPNB1 TWNK POLD1 SSBP1 H2BC21 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 POLE RFC1 H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 GINS1 GINS2 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 POLD3 GINS3 CDC26 GINS4 CDC27 MCM3 POLD4 MCM4 POLD2 ANAPC7 MCM5 MCM6 UBE2C MCM2 POLE4 UBE2E1 FEN1 UBE2S CDC16 CCNE2 ANAPC4 POLE2 CCNE1 ANAPC5 ANAPC1 POLE3 ANAPC2 H2AC14 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling IL11 CBL CNTF LIF SOCS3 STAT1 TYK2 CNTFR PTPN11 IL11RA STAT3 CLCF1 LIFR IL31 OSM IL31RA OSMR IL6 IL6ST CRLF1 JAK1 CTF1 JAK2 IL6R CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway NFKB1 RELA PYCARD MALT1 CASP8 IL1B PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis INHA INHBE FSHB LHB PCSK1 CGA TSHB INHBB INHBA POMC INHBC BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization DDO STX1A PHYH-4 IDE SCP2 GSTK1 CROT APP HSCB TOMM20 TOMM22 HSD17B4 CAT TOMM40 TOMM7 SLC25A6 TOMM70 HAO1 ACAA1-1 NUDT7 CS UBE2D3-1 EHHADH-1 IDH3G AGPS ATP5MC1 GRPEL1 VAPA UBA52 CYC1 COX19 VAMP2 ABCD2 COX17 PEX3 RPS27A UBB;UBC CRAT VDAC1 NUDT19 CHCHD4 CHCHD5 TIMM17B PMPCB CMC2 TIMM23 PMPCA TIMM13 CHCHD10-1 TIMM50 PITRM1 GRPEL2 SLC27A2 PAOX TIMM8B DNAJC19 COA4 PECR ATAD1 TIMM8A TIMM44 PEX16 MTX2 PEX10 FIS1 PEX2 HMGCL GFER PEX11B TIMM10B PEX12 SAMM50 GDAP1 PEX13 CHCHD7-1 PEX26 PEX14 CHCHD3 PXMP4 ACOX2 ACOX3 PIPOX MTX1 ACBD5-1 DHRS4 HACL1 ACO2 EMD ACOX1 TYSND1 ABCD1 TIMM17A-1 CHCHD2 ACOT8 ACOT2;ACOT1 ECH1 SEC61G OTC SEC61B TIMM22 TIMM10 LDHD SLC25A17 AGXT FXN PRNP SLC25A12 HSPD1 SLC25A4 STX5 ATP5F1A ATP5F1B ACOT4 SLC25A13 ZFAND6 MPV17 USP9X HMOX1 PEX1 NDUFB8 PEX7 PEX6 GNPAT NOS2 EPHX2 OTOF IDH1 PEX19 HSPA9 UBE2D3;UBE2D2 COQ2 UBE2D1 AMACR LONP2 DAO PXMP2 TIMM21 BCS1L BAAT ABCD3 UBL4A CAMLG SGTA BAG6 GET1 GET3 GET4 TAZ DECR2 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway VLDLR FYN RELN SH3KBP1 DAB1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 TGFB1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome PYCARD AIM2 CASP1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor DLG3 DLG4 CALM3;CALM1 DLG1 GRIK5 GRIK3 GRIK4 NCALD GRIK1 GRIK2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis DGKZ DGKQ DGKK DGKI DGKH ABHD6 PRKCE MGLL DAGLA PRKCQ RASGRP2 RASGRP1 DAGLB ITPR1 ITPR2 PRKCD ITPR3 DGKG DGKE DGKD DGKB TRPC7 DGKA TRPC6 ABHD12 PRKCH TRPC3 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis ST3GAL4 ST3GAL3 B3GALT4 ST6GALNAC6 B3GALT5 B3GALT2 B3GALT1 FUT2 FUT4 FUT6;FUT5;FUT3 FUT7 B4GALNT2 FUT9 ST3GAL6 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins FGG SOS1 ITGA2B TLN1 VWF SRC FN1 RAP1A ITGB3 PTK2 FGB FGA RAP1B APBB1IP LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism ELOVL1 ELOVL2 ELOVL3 FADS2 ACSL1 ABCD1 ELOVL5 FADS1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein PRKCSH MOGS GANAB MGAT1 CANX RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes NCBP1 NABP1-1 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 CDK7 INTS9 INTS8 INTS11 INTS12 GTF2A1 INTS13 GTF2A2 INTS14 INTS10 ICE1 ICE2 TAF9 SSU72 NABP2 PHAX POLR2A ZNF143 POLR2B ELL2 POLR2C ELL3 ZC3H8 POLR2D RPRD2 RPAP2 RPRD1B SP1 POLR2G RPRD1A SNAPC5 SNAPC1 POLR2I SNAPC2 SNAPC3 SNAPC4 TBP TAF13 TAF11 POU2F1 NCBP2-1 TAF8 POU2F2 TAF6 TAF5 CCNK CCNT1 GTF2B POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L GTF2E1 GTF2E2 SUPT4H1-1 SRRT SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 PCF11 ELL SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism P2RY2 SLC34A2 SLC34A1 ADRA2C ADRA2A SFTPB SFTPC CTSH CSF2RB TTF1 CSF2RA CKAP4 GATA6 NAPSA ADORA2B CCDC59 ADORA2A PGA4;PGA3;PGA5 ADGRF5 ADA2 LMCD1 ABCA3 ZDHHC2 SFTPD PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses DLGAP3 IL1RAPL1 DLGAP4 STXBP1 SHANK2 STX1A SHANK1 NLGN3 NLGN1 NLGN2 EPB41 NRXN3 NRXN2 BEGAIN EPB41L5 GRIN2A EPB41L2 PDLIM5 NLGN4X;NLGN4Y HOMER1 HOMER2 LRFN3 SYT7 LRFN2 PTPRF GRIN2B LRFN4 SYT12 GRIN1 LRFN1 APBA3 APBA2 APBA1 GRM1 GRM5 PTPRD PPFIBP2 SLITRK2 SLITRK1 SLITRK4 IL1RAPL2 SLITRK6 RTN3 LRRC4B GRIA1 PPFIBP1 EPB41L1 GRIA3 GRIA4 SHANK3 SLITRK3 DLG1 SLITRK5 SYT9 PTPRS FLOT2 SHARPIN CASK LIN7A LIN7C GRIN2C GRIN2D NTRK3 DLG2 DLG3 DLG4 SYT2 SYT1 NRXN1;NRXN3;NRXN2 PPFIA1 FLOT1 PPFIA4 PPFIA3 PPFIA2 DBNL SYT10 LIN7B SIPA1L1 LRRTM3 LRRTM4 LRRTM1 LRRTM2 DLGAP1 HOMER3 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function MDM2-2 CTNNA1 CDH1 JUP PSMD12 VCL PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BANP ADRM1 CTSS PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 CTSB CTSV;CTSL UBA52 DNM2 RPS27A UBB;UBC RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway MED13L TLR2 MED1 RAB5B CSNK2A1;CSNK2A3 MED4 MED6 NCL-1 PPP1CC MED7 CCNC-1 SDC4 SEC11A SEC11C SDC2 CREBBP SDC3 TLR6 SDC1 MED16 MED17 SPCS3 MED12 SPCS2 RAB5A MED14 SPCS1 MED13 EGFR MED10 JAK1 PPP1CB MED19 MED15 MED18 MED11 TYK2 MED27 PPP1CA MED23 HSP90AA1 DDX58 MED26 MED24 ISG15 MED29 TLR7 UBE2L6 HERC5 MED22 MED20 IFIH1 MED25 TRIM25 GPC1 ARIH1 MED21 GPC3 GPC2 XPO1 GPC5 UBA52 GPC4 GPC6 STAT2 MED31-1 AGRN EP300 RPS27A UBB;UBC HSPA8 MED30 RBX1 IFNAR1 CDK8 BCAP31 KPNB1 MAVS HSPG2 HSP90AB1 IRF3 BECN1 MED8 MED9 CUL5 IFNB1-4 CSNK2A2 TLR3 LY96 CSNK2B CDK19 CD14 TLR4 H2BC15;H2BC3;H2BC11;H2BC12 IGF1R CX3CR1 CLEC4M;CD209-2 FURIN RAB5C MED28-1 MAP1B EIF2AK2 ELOC-1 ELOB DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type BCAN VCAN DCN CSPG5 NCAN CHST14 BGN REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion ABCC8 STXBP1 STX1A GNA14 GNG10 GNAS-1 GNA15 GNG2 GNG5 GNG4 PRKAR1B GNA11 PRKAR1A GNG8 CHRM3 INS;INS-IGF2 ADCY8 ADCY6 ADCY5 GNG13 CACNB2 PRKACB-1 CACNB3 GNAQ CACNA2D2 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 FFAR1 SNAP25 IQGAP1 GNAI1 GNAI2 CD36 KCNC2 GCG PRKACA-1 AKAP5 KCNS3 ADRA2C ADRA2A KCNJ11 MARCKS GNGT1 RAPGEF3 PRKCA VAMP2 RAPGEF4 PRKAR2B CACNA1A PLCB3 CACNA1D GLP1R SLC2A1 SLC2A2 CACNA1C KCNB1 PLCB1 CACNA1E AHCYL1 PLCB2 KCNG2 RAP1A SYT5 ACSL4 ACSL3 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity APAF1 UACA AVEN DIABLO-1 CASP9 MAPK1 MAPK3 CYCS-1 APIP XIAP TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation MARS1 AIMP1 SARS1 AIMP2 EPRS1 RARS1 QARS1 IARS1 LARS1 KARS1 EEF1E1 PPA2 RARS2 AARS2 PARS2 MARS2 DARS2 AARS1 HARS2 YARS2 HARS1 YARS1 FARS2 WARS1 WARS2 LARS2 GARS1 NARS1 DARS1 SARS2 NARS2 FARSA TARS2 CARS1 PPA1-1 IARS2 TARS1 VARS2 FARSB VARS1 CARS2 EARS2 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome ABCC9 KCNJ11 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 IFNGR1 TRIM46 IFNGR2 TRIM45 GBP2;GBP3;GBP1 TRIM35 TRIM38 TRIM31 B2M TRIM29 TRIM26 TRIM14 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRIM10 MID1 JAK2 IRF4 VCAM1 SOCS1 IRF6 IRF9 PIAS1 IRF8 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 SUMO1 HLA-DPA1 IRF1 IRF2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IRF3 HLA-DRA TRIM8 TRIM6 GBP7;GBP4 TRIM5 TRIM2 IRF7 TRIM3 SMAD7 JAK1 YBX1 FCGR1A CAMK2B CAMK2D CAMK2A NCAM1 CAMK2G PML PTPN11 PTPN6 SP100 RAF1 TRIM25 GBP6 CD44 SOCS3 PRKCD PTAFR PTPN1 OASL TRIM21 IFNG OAS1 OAS3 IRF5 MAPK1 MAPK3 GBP5-1 MT2A CIITA IFI30 TRIM68 ICAM1 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones MBTPS2 ATF6B HSPA5 MBTPS1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification COG4 COG3 COG2 SPTBN2 BET1L ANK2 TGFA GOLGB1 SPTBN4 B4GALT6 SPTBN5 CTSC B4GALT4 B4GALT5 TRAPPC3 TRAPPC1 GOSR2 CAPZA3 ST6GAL1 ACTR10 TRAPPC4 TRAPPC5 SAR1B TRAPPC9 ST3GAL4 ARFGAP3 GOLGA2 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 SPTA1 TRAPPC2;TRAPPC2B GRIA1 B4GALT1 TRAPPC6A NSF TMED2-1 TRAPPC6B ANK3 RAB1A RAB1B TRAPPC10 ACTR1A AREG ARF1 CSNK1D SCFD1 SPTBN1 MGAT5 GBF1 MGAT1 COL7A1 DYNC1I2 MGAT2 DCTN2 DCTN3 SEC24D-1 COPB1 MAN2A2 MGAT3 ST8SIA6 SPTAN1 CHST8 ST8SIA2 FUCA1 ST8SIA3 CD59 CD55 DYNC1H1 DYNC1LI1 KDELR1 DYNC1LI2 LHB ANK1 FUT8 MAN2A1 SEC31A DYNC1I1 MIA2 MIA3 INS;INS-IGF2 CAPZB MAN1A2 MAN1C1 TMEM115 MAN1A1 CTSZ MGAT4A-1 CHST10 DCTN1 MANEA SEC22B SEC23A CAPZA1 LMAN1 CAPZA2 SEC24B STX5 SEC24A YKT6 MGAT4C KDELR2 MGAT4B COPB2 COPA SEC24C CGA COPE MCFD2 SERPINA1 PPP6C TMED3 PPP6R1 TMED7 PPP6R3 LMAN1L TMED9 COPZ2 GORASP1 COPZ1 SEC22A SEC22C NAPB TMED10 ARF5 STX17 LMAN2L USO1 FUT6;FUT5;FUT3 NAPG LMAN2 SEC31B ANKRD28 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 ARCN1 COPG2 FOLR1 CNIH3 COPG1 BET1 F5 F8 B4GALT2 B4GALT3 NAPA TFG SPTB GOSR1 ARFGAP1 TRAPPC2L COG8 TBC1D20 COG7 PREB COG6 KDELR3 COG5 SEC13 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events CAMK2G ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG PRKCD NBEA PRKCA CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 KPNA2 PRKX CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants ALK LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy VPS37C VPS37D VPS37A VPS37B IFT88 CHMP3 CHMP6 CHMP7 CFTR CHMP4C CHMP4B PLIN2 CHMP4A VPS28 TSG101 MVB12B MVB12A UBA52 HDAC6 CETN1 PLIN3 CHMP2B HBD;HBB RNASE1 RPS27A PCNT CHMP2A UBAP1 ARL13B UBB;UBC HSPA8 PARK7 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSG STS ARSD-1 ARSA ARSL ARSB ARSJ ARSK ARSH SUMF2 ARSI SUMF1 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism SLC44A1 SLC44A2 BHMT DMGDH ALDH7A1 SARDH SLC22A4 CHDH DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 PLCG1 HRAS PIK3R1 FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants PDGFRA DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations MGAT5B-1 POMT2 DAG1 POMT1 POMGNT1 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling TGFBR3 GIPC1 FGF2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC34A2 SLC20A1 SLC34A1 SLC20A2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen GP1BA GP5 GP9 VWF GP1BB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation UBE2V1 MAPKAPK2 MAP2K6 IRAK1 IRAK2 TRAF6 MAP3K7 MAP2K3 MAPK14 MAPK11 IKBKG NOD1 MAPKAPK3 NOD2 UBE2N TAB3 RIPK2 TAB2 TAB1 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 HES1 SNW1 MAMLD1 MIB2 FABP7 WWC1 WWP2 PBX1 KAT2B DLGAP5 PTCRA KAT2A DLL4 HES5 PSENEN NEURL1 TACC3 MIB1 HEY1 HEY2 CREBBP JAG1 UBA52 ADAM10 NOTCH1 STAT1 PLXND1 RBPJ DLL1 JAG2 PSEN1 HEYL MAML2 EP300 MAML1 RPS27A NCSTN PSEN2 UBB;UBC NEURL1B EGF APH1A EGFR APH1B MAML3 NOTCH3 YBX1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 DDIT3 RPS11 RPL10A GCN1 RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ATF2 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 ASNS RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 CEBPG RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 EIF2S2 EIF2S3;EIF2S3B RPLP2 EIF2S1 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 CEBPB EIF2AK4 ATF4 RPL18A RPL23A FAU ATF3 TRIB3 RPL12-1 RPS27A RPS9 RPS7 RPS8 IMPACT RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events PPP2R1A PDE4A PPP1CA PPP3R1 PDE4C PPP2CB;PPP2CA PRKAR2B PRKAR1B PRKAR1A PPP2R5D CDK5 PPP1R1B PPP2R1B PPP3CC PDE4D-1 CALM3;CALM1 PPP3CA PPP3CB PRKACB-1 PRKAR2A PRKACA-1 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 GAB1 MET PTPN11 HGF MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes HSPG2 GJA1 ITGB1 PANX1 ITGA5 SPP1 P2RX7 CACNA1H ITGAV ITGB3 CACNG7 CACNB2 CACNB3 CACNB1 PIEZO1 CACNA2D1 AKT1 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling AKT2 SLC38A9 AKT3 STK11 PGK1 PRKAB2 AKT1S1 RHEB EIF4EBP1 PRKAB1 RRAGA CAB39 RRAGC RRAGB MLST8 RRAGD FKBP1A EEF2K PRKAA1 CAB39L STRADA PRKAG2 STRADB MTOR TNRC6C MOV10 TNRC6A-1 PRKAA2 AGO4 AGO2 PRKAG1 AGO3;AGO1 TNRC6B PRKAG3 EIF4E RPTOR EIF4B YWHAB AKT1 TSC2 TSC1 PPM1A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RPS6 EIF4G1 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde KPNA2 CAMK2G CALM3;CALM1 CAMK4 CAMKK1 CAMK2B CAMKK2 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling SOS1 EREG BTC EGF AREG TGFA HRAS EGFR HBEGF EPGN NRAS DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization HVCN1 ADAM2 ZP3;POMZP3 ACR IZUMO1-1 OVGP1 IZUMO3 IZUMO2 IZUMO4 ZP1 ZP2 CATSPER1 ZP4 ADAM21 KCNU1 CATSPER3 ADAM20 ADAM30 CATSPERB CATSPER2 B4GALT1 CATSPERD CATSPER4 CD9 CATSPERG SPAM1 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT GALT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 ALOX5AP MAPKAPK2 CYP4F22 ALOX15 GGT1 LTA4H DPEP2 CYP4B1 DPEP1 LTC4S ALOX5 PTGR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ABCC1 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA6 PSMC5 FBXL7 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 FBXL18 PSMA1 PSMC4 PSMC1 SKP1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 AURKA PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BCL7C SMARCA2 BCL7B BRD7 SMARCA4 SMARCC1 SMARCC2 ACTB-1 SMARCE1 SMARCD1 SMARCB1 SMARCD2 PHF10 ARID2 BCL7A SMARCD3 PBRM1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome NLRP1 BCL2 BCL2L1 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland EGF FGF10 AREG TGFA PRL MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease DIS3 SKIV2L EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 WDR61 HBS1L TTC37 NT5C3B DCPS ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 PTTG1;PTTG2 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PLK1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events FRS2 NGF KIDINS220 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 YWHAB BRAF CRK MAPK3 CRKL NTRK1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism FMO1 BHMT ENOPH1 TXN2 TST MAT1A ADI1 MPST GOT1-1 BHMT2 CDO1 TSTD1 ADO ETHE1 CTH CSAD SUOX MRI1 MTR-1 GOT2-1 MTRR AHCY CBS;CBSL APIP MTAP GADL1 SQOR SLC25A10 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle MFN1 MYO19 MFN2 TRAK1 TRAK2 RAP1GDS1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense CALM3;CALM1 UBB;UBC GBP6 GBP2;GBP3;GBP1 UBE2D3;UBE2D2 CASP5;CASP4 RPS27A UBA52 GBP7;GBP4 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition AKT2 AKT3 FBXO5 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 E2F1 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 PPP2R1A CDC6 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 PCNA AKT1 UBA52 CUL1 RPA1 PTK6 RPA2 CCNB1 CDK4 CDK2 PPP2CB;PPP2CA RPA3 RPS27A PPP2R1B UBB;UBC MCM10 DBF4 CDK1 CDK7 MNAT1 DHFR2;DHFR CKS1B PPP2R3B TYMS RBL2 CABLES1 RBL1 WEE1 MYC HDAC1 RBBP4 MAX CCND1 POLE LIN54 LIN37 LIN9 LIN52 TK1 CDC45 MCM7 MCM8 MCM3 MCM4 MCM5 E2F5 MCM6 E2F6 MCM2 POLE4 RRM2-1 CCNE2 POLE2 CCNE1 RB1 POLE3 CCNH ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) MVD HELZ2 GGPS1 MVK MED1 IDI1 HMGCS1-1 FDFT1 TM7SF2 SQLE ACACB ACACA CYP51A1 ELOVL6 TGS1 CREBBP SP1 SCD PMVK FDPS RXRA SREBF2 GPAM CARM1 MTF1 CHD9 PPARA NFYA-1 DHCR7 TBL1XR1 NFYB FASN SC5D LSS NFYC NCOA1 NCOA2 NCOA6 SMARCD3 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription RB1 DDX5 ZCRB1 VHL MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1-1 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance APOBR APOC1 VLDLR APOC4 APOB LSR MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase CDK1 NUP133 NUP50 POM121;POM121C NUP54 NUMA1 RAB2A GORASP2 BLZF1 SMC4 SMC2 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP43 H2BC21 GOLGA2 RAE1 RANBP2 ARPP19 EMD NCAPH2 NCAPG2 H2AC20 ENSA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 NCAPD3 MASTL MCPH1 LPIN1 LPIN2 NUP35 LPIN3 RAB1A RAB1B NUP37 PPP2R1A NUP107 NUP188 BANF1 LEMD3 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 GORASP1 NUP93 LMNB1 NUP205 USO1 NEK9 NEK6 H2BC15;H2BC3;H2BC11;H2BC12 AAAS NEK7 H2BC5 PPP2R2A;PPP2R2D NUP160 NUP85 H2BC1 NUP214 TPR NUP88 PRKCA NUP155 CCNB2 CCNB1 NUP153 PPP2CB;PPP2CA SET-1 PPP2R1B H2AC4 NUP62 MAPK1 RB1 KMT5A VRK1 LEMD2 PLK1 CTDNEP1 CNEP1R1 PRKCB NDC1 H2AC14 SEC13 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes CDK1 NPM1-2 CCNA2-1 CCNA1 CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT11 PLK2 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 SFN CARM1 ZNF385A E2F4-1 TP53 TFDP1 PCBP4 RBL2 TFDP2 RBL1 PLK3 PRMT1 E2F1 GADD45A E2F7 E2F8 ARID3A BAX CDKN1A BTG2 CDKN1B TNKS1BP1 CNOT6L PCNA PLAGL1 AURKA CCNB1 CDK2 EP300 CCNE2 CCNE1 CENPJ CDC25C CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC2 CDC6 MCM8 ORC5 ORC4 ORC6 ORC1 ORC3 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPKAPK2 ATF1 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 BLVRB BLVRA HELZ2 STAT3 MED1 NLRP3 COX7B COX7C TGS1 CREBBP SIN3A COX8A COX8C RXRA CARM1 PPARA COX4I1 HBD;HBB COX4I2 TXNIP COX5B COX5A HBA2;HBA1 ALB NCOA1 NCOA2 COX7A2L-1 NCOA6 SMARCD3 HDAC3 COX6C MAFK NFE2L2 HMOX1 NCOR2 HMOX2 COX6A1 COX6A2 NCOR1 COX7A2 COX6B2 COX6B1 STAP2 PTK6 NDUFA4 CHD9 CYCS-1 BACH1 TBL1XR1 HM13 FABP1 ABCC1 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle MYO19 RHOT1 TRAK1 TRAK2 RAP1GDS1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation HDAC4 IHH GLI2 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function CTNND1 TNRC6C MOV10 TNRC6A-1 AGO4 SNAI1 AGO2 CDH11 CTNNB1 AGO3;AGO1 TNRC6B ADAM33 CTNNA1 CDH8 JUP ADAM19 ANGPTL4 CDH24 SP1 PRDM8 HEYL ILF3 FOXF1 BHLHE22 HOXC8 ZEB2 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity AKT2 AKT3 CSNK2A1;CSNK2A3 CCNA2-1 CCNA1 TAF9 PRKAB2 TP53RK NOC2L SGK1-1 KAT5 TAF9B CHEK2 CHEK1 TP63 DAXX HUS1 TAF15 PRKAB1 TAF12 TAF13 TAF10 TAF11 SSRP1 DNA2 RHNO1 PHF20 TAF8 L3MBTL1 TAF7 MEAF6 MAPKAP1 TAF6 NUAK1 TAF5 TAF4 TAF3 TP53BP2 ATRIP TAF2 TAF1 BANP BARD1 PLK3 PRKAG2 TPX2 RAD17 ATM PPP2R1A ATR TP73 SETD9 PRKAG1 BRCA1 PRKAG3 ING5 ING2 PRMT5 BRD1 RMI2 RMI1 TOP3A MBD3 BRPF3-1 AKT1 UBA52 WRN RICTOR BRD7 GATAD2B AURKA RPA1 GATAD2A RPA2 CDK2 HIPK1 PPP2CB;PPP2CA POU4F1 POU4F2 HIPK2 TTC5 EP300 RPA3 PPP2R5C RPS27A CCNG1 RAD1 PPP2R1B UBB;UBC MRE11 MAPK14 MAPK11 KMT5A NBN USP7 USP2 CDK1 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 MAP2K6 STK11 CDK5 BRPF1 CHD4 CHD3 JMY PIN1 MDM4 RAD9B RAD9A PRR5 DYRK2 PPP1R13B EXO1 PIP4K2A TBP PDPK1 PPP1R13L PIP4K2B MLST8 PIP4K2C TOPBP1 ZNF385A RFC5 RFC3 RFC4 TP53 RFC2 PRDM1 PRKAA1 RNF34 AURKB TP53INP1 HDAC2 RBBP8 RFFL HDAC1 PML MTOR RAD50 CSNK2A2 PRKAA2 RBBP4 SUPT16H CSNK2B RBBP7 MTA2 PIP4P1 CDK5R1 CDKN2A TAF4B BRIP1 TAF7L EHMT2 EHMT1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion KCNS3 GNG10 GNAS-1 GNG2 GNG5 GNG4 PRKAR1B GNG8 PRKAR1A ADCY8 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 GNGT1 ITPR2 RAPGEF3 GNB5 ITPR3 RAPGEF4 PRKAR2B GLP1R KCNB1 IQGAP1 KCNG2 RAP1A KCNC2 GCG AKAP5 PRKACA-1 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination PRKDC TMEM129 HLTF RNF152 SHPRH CTR9 PEX10 PEX2 RTF1 PEX12 PEX13 PEX14 RNF40 RNF144A UBE2G1 SELENOS UBE2G2 PAF1 WAC-1 RNF181 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RAD18 DERL1 USP5 UBE2N UBE2Z RRAGA UBE2E3 UBE2T UBE2V2 RNF20 UBA6 UBE2D3-1 USP9X UBE2H UBE2B CDC73 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LEO1 CDC34 UBE2W UCHL3 BCL10 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 PCNA UBE2D3;UBE2D2 UBA1 UBA52 UBE2K H2BC1 UBE2Q2 UBE2D1 UBE2R2 VCP-1 RPS27A UBE2C UBE2E1 UBB;UBC UBE2J2 UBE2S WDR61 USP7 OTULIN RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 CSF2 CREBBP PRKCB LGALS3 CBFB DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis RIPK3 FADD MLKL TRADD TRAF2 CASP8 RIPK1 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA3 LAMA2 LAMA4 FN1 LAMB3 LAMB2 LAMB1 VTN LAMA1 LAMC3 LAMC2 LAMC1 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing NUP133 NUP50 URM1 WDR4 POM121;POM121C THADA EPRS1 NUP54 LAGE3 OSGEP THG1L ALKBH8 TRMT44 C9orf64 TRDMT1 PUS3 TRMT10A METTL1 NSUN2 TPRKB ADAT1 NUP42 TRMT1 NSUN6 CDKAL1 PUS7 FTSJ1 TP53RK ADAT3 NUP43 TRIT1 ADAT2 QTRT1 TRMT9B DUS2 RAE1 QTRT2 RANBP2 CTU2 CTU1 TRMT6 CSTF2 TRMT13 TRMT11 TRMT61A NUP35 RAN NUP37 CPSF4 CPSF1 TRMT112 NUP214 TYW5 TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 POP5 POP7 POP1 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 TSEN54 RPP38 RPP21 RPP25 TSEN34 DDX1 RPP14 C2orf49 CLP1 RTRAF RPP40 XPOT FAM98B YRDC NUP107 TRMU OSGEPL1 NUP188 MTO1 TRMT61B GTPBP3 NUP210 NUP93 TRMT10C PRORP TRNT1 NUP205 HSD17B10 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly ABCA1 A2M PRKACB-1 APOA1 ZDHHC8 PRKACA-1 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency OTC IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis ALDH9A1 SHMT1 TMLHE BBOX1 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects PNP-1 IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 IFIT1 IFIT3 IFIT2 SKP1 RPS27L RPS15A RPS3 IFIT5 RPS2 CUL1 FAU RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGF20 FGF23 INSR TGFA PIK3R3 PIK3R6 PIK3R5 IRS2 LCK SRC PIP5K1A PIP5K1B PIP5K1C EGF ERBB2 EGFR PDGFRA FGF6 HGF GAB1 PPP2R1A MET AREG RAC1 NRG1 NRG2 FGF7 EREG BTC FGF22 FGF3 FGF10 NRG3 NRG4 HBEGF KIT NTRK3 AKT1 NTF3 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG PPP2R5E VAV1 IER3 FLT3LG PDGFB CD19 CD28 STRN GAB2 IL33 CD86 FGF2 IRAK1 KLB CD80 PDGFRB INS;INS-IGF2 FGF19 FGFR4 IL1RL1 TRAT1 FLT3 PIK3AP1 ESR1 PIP4K2A PIP4K2B PIP4K2C PIK3CD TRAF6 PIK3CG IRS1 PIK3R2 ESR2 PIK3CB PIK3R1 FYN FRS2 PIK3CA MYD88 PTPN11 IRAK4 EPGN NTRK2 BDNF MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes ATM BAX TP73 NDRG1 PMAIP1 CHM BID BCL2L14 BBC3 ZNF420 FAS AIFM2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP10 TP53I3 BCL6 CREBBP PERP TP63 PPP1R13B NLRC4 PIDD1 CASP6 CASP2 CASP1 APAF1 TP53 RABGGTB RABGGTA STEAP3 TP53BP2 BIRC5 PRELID3A TMEM219 BNIP3L TP53INP1 PRELID1 CRADD IGFBP3 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism SDSL SDS RIDA DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism VCAN EXT1 EXT2 CSPG5 FMOD CHST6 LUM CHSY1-1 CHST14 B4GALT7 PRELP DCN GPC1 SDC4 GPC3 KERA B3GAT3 SDC2 GPC2 SDC3 GPC5 GPC4 SLC26A2 OGN HSPG2 GPC6 BCAN ST3GAL3 CHST3 OMD B3GALT6 ACAN B4GALT1 AGRN SDC1 PAPSS2 HEXB NCAN HEXA BGN CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME ALB ABCG2 SLCO1A2 SLC22A1 SLC22A8 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters ABCG5 ABCC8 NUP133 SLC34A2 SLC34A1 SLC6A19 SLC39A4 NUP50 SLC36A2 POM121;POM121C SLCO2A1 SLC6A14 ABCC6 NUP54 ABCC9 SLC26A4 SLC7A7 SLC26A3 AVPR2 SLC7A9 NUP42 NUP43 SLC26A2 PSMD12 PSMD11 PSMD14 RAE1 PSMD13 RANBP2 PSMA7 SLC35A2 PSMD8 SLC35A3 SLC33A1 SLC35C1 SLC22A12 PSMB6 SLC22A18 PSMB7 PSMD6 ABCB4 PSMB4 PSMD7 PSMB5 PSMB2 NUP35 PSMB3 PSMD2 PSMD3 SLC29A3 SLC27A4 PSMB1 PSMD1 SLC17A8 SLC5A5 ADRM1 NUP37 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 ABCA1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 SLC24A5 PSMA1 SLC40A1 PSMC4 PSMC1 HEPH APOA1 CFTR KCNJ11 SLC5A7 ABCB6 SLC5A2 ABCA3 UBA52 NUP214 ERLIN1 ERLIN2 SLC9A6 CP SLC9A9 SLC16A1 ABCB11 VCP-1 RPS27A DERL2 RNF5 UBB;UBC OS9 RNF185 LMBRD1 SLC22A5 SLC12A3 SLC12A1 SLC12A6 DERL3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 DERL1 SLC3A2 BSG SLC5A1-1 SLC35A1 ABCD1 ERLEC1 ABCA12 SLC2A9 SLC6A5 SLC6A2 SLC6A3 SLC2A10 NUP107 NUP188 NUP210 RHAG NUP93 NUP205 AAAS NUP160 NUP85 SLC24A1 TPR SLC24A4 NUP88 GCKR NUP155 GCK SLC11A2 NUP153 ABCD4 SLC2A1 SLC2A2 SLC4A1 SLC4A4 AVPR1B HK1 SLC1A1 AVPR1A SLC1A3 NUP62 SLC17A5 AVP SLC3A1 SLC20A2 SLC6A20 NDC1 ABCG8 SEC13 ABCC2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ TTN-1 STXBP3 STX4 CAP1 VEGFA CD109 RAB27B PRKCG APP TLN1 ISLR HABP4 CHID1 PSAP GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 SERPINE1 LY6G6F;LY6G6F-LY6G6D ALB EGF ENDOD1 APOH PECAM1 SPARC VTI1B MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 PCDH7 CTSW TIMP3 HGF ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD AHSG LHFPL2 PCYOX1L FAM3C ACTN1 LEFTY2;LEFTY1 APLP2 TMX3 APOA1 SELENOP SCG3 PFN1 HSPA5 RARRES2 CYRIB SCCPDH LAMP2 LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CDC37L1 TUBA4A BRPF3-1 STXBP2 PPBP PRKCA ITGA2B VWF ABCC4 PF4;PF4V1-1 TGFB2 TGFB3 MMRN1 PRKCB CYB5R1 TF PDGFB APOOL SELP ORM2;ORM1 QSOX1 CD63 ACTN4 VCL IGF2 A1BG FN1 IGF1 SERPINA3 PPIA A2M SERPINF2 ALDOA HRG THBS1 FLNA CFD TIMP1 SERPINA1 TGFB1 CALM3;CALM1 ACTN2 ITGB3 PROS1 F13A1 CFL1 FGB FGA FGG F5 PLG F8 SOD1 SERPING1 CLU KNG1 CD9 GAS6 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding OGG1 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling SOS1 GNA13 TBK1 ULK1 RASGRF2 TNF PLEKHG2 TAX1BP1 SOS2 PRKCI PRDM4 YWHAE IKBKE NGFR RIPK2 RNF31 XIAP OTUD7B SPATA2 TNFAIP3 SMPD3 SHARPIN USP21 USP4 SMPD2 RACK1 MIB2 UBE2D3-1 TNFRSF1A CYLD PLEKHG5 RBCK1 OTUD1 BIRC2 RAC1 CHUK BIRC3 OPTN-1 RHOA CASP10 KALRN IKBKB CFLAR IKBKG NET1 UBA52 NGF AKAP13 MAPKAPK2 VAV3 RPS27A TRIO PSEN2 UBB;UBC ITSN1 MAP3K7 APH1A VAV1 APH1B VAV2 TIAM2 SPPL2B SPPL2A PREX1 CLIP3 ARHGEF3 NSMAF ARHGEF4 MAPK8 ARHGEF1 OTULIN USP2 ARHGEF2 ARHGEF7 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF IRAK1 PSENEN ABR LINGO1 MAG OMG RTN4 SQSTM1 TAB3 TAB2 TAB1 ADAM17 ARHGEF33 ARHGEF37 ARHGEF38 PSEN1 CASP2 NCSTN TRAF6 ARHGDIA ARHGEF40 FGD1 FGD2 FGD3 FGD4 HDAC2 ARHGEF26 BEX3 HDAC3 HDAC1 MYD88 CASP3 TRADD FASLG MCF2 TRAF2 CASP8 TNFSF10 ECT2 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ARHGEF39 FADD BAG4 UBE2D3;UBE2D2 NFKBIA TRAF1 TIAM1 ARHGEF10L UBE2D1 RELA MCF2L ARHGEF11 AATF ARHGEF10 MAGED1 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 NFKB1 ARHGEF18 ITGB3BP STUB1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication ORC2 CDK1 PPP2R1A PRIM2 PRIM1 CCNB1 POLA1 MCM8 PPP2CB;PPP2CA POLA2 PPP2R1B TFDP1 TFDP2 RB1 ORC5 PPP2R3B ORC4 ORC6 E2F1 ORC1 ORC3 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression NR1H4 G0S2 MED13L NR1H3 FAM120B AGT MED1 ACSL1 MED4 MED6 AHR MED7 PEX11A CCNC-1 PPARGC1A PPARGC1B CREBBP RGL1 SREBF2 CLOCK ABCB4 ACADM ESRRA MED16 MED17 NFYA-1 MED12 MED14 MED13 MED10 CD36 RXRB NCOA1 NCOA2 MED19 NCOA6 MED15 NCOA3 ABCA1 MED18 HMGCS2 MED11 MED27 MED23 APOA2 NCOR2 APOA1 APOA5 NCOR1 MED26 MED24 TXNRD1 MED29 MED22 MED20 MED25 PLIN2 ANGPTL4 MED21 GPS2 MED31-1 CHD9 EP300 CPT2 CPT1A SLC27A1 TBL1XR1 TIAM2 FABP1 FADS1 MED30 HELZ2 CDK8 HMGCS1-1 NRF1 NPAS2 SULT2A1-4 TGS1 NR1H2 RORA GLIPR1 SP1 ANKRD1 RXRA CYP7A1 ALAS1 CARM1 PPARG PPARA FHL2 ME1 MED8 NFYB MED9 ARNT NFYC GRHL1 SMARCD3 HDAC3 ARNTL TNFRSF21 ARNT2 FDFT1 NR1D1 CDK19 CYP1A1 MTF1 AHRR TRIB3 MED28-1 THRAP3 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors FFAR4 FFAR1 FFAR2 FFAR3;GPR42 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle FLOT2 FRS2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST PLEKHG5 KIDINS220 TXNL1 ARHGAP35 LEMD3 TMEM59 GRB7 VANGL1 CCDC88A PTPN13 DEPDC1B VANGL2 UBXN11 CPD DLG5 CAV1 FAM135A PKP4 RBMX EPHA2 KIF14 RND1 RRAS2 TFRC PIK3R2 STMN2 PIK3R1 STIP1 ALDH3A2 FRS3 RASAL2 ARHGAP5 MUC13 PLXNA1 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome GAB1 PAG1 PIK3CA PTPN11 AREG TGFA SRC EREG BTC EGF CSK EGFR PIK3R1 HBEGF EPGN PXN DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication DPM1 DPM2 DPM3 IPO7 DNAJC10 EIF4A3 P4HB VIM SCAP MAP1LC3B2;MAP1LC3B-1 KPNB1 OST4 SEC11A UBE2I RPN2 SEC11C OSTC STT3A DNAJA2 RPN1 STT3B RTN3 SUMO1 DNAJC3-1 DDOST KPNA4-1 DAD1 HYOU1 RRBP1 ACOT2;ACOT1 ATL2 SPCS3 SPCS2 SPCS1 MAGT1 YBX1 EIF4A2 NACA EIF4A1 PRKG2 APOA1 KPNA1 EIF4E HSPA5 CANX BAG2 HSPA1A;HSPA1B P4HA1 EIF4G3 P4HA2 EIF4G2 EIF4E3 XPO1 P4HA3 DNAJB11 UBA52 XRN1 SUN2 NPLOC4 UFD1 CALR-1 KPNA7 VCP-1 KPNA5 RPS27A NMT1 KPNA3 TUSC3 KPNA2 UBB;UBC HSPA8 PABPC1;PABPC3 BTF3 FASN EIF4G1 HDLBP PDIA3 TMEM258 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes USP9X UBE2H UBE2B UBE2G1 UBE2G2 UBE2W CDC34 UCHL3 USP5 UBE2D3;UBE2D2 UBA1 UBA52 UBE2K UBE2Z UBE2Q2 UBE2D1 UBE2R2 UBE2E3 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S UBE2T UBA6 USP7 OTULIN INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling SMARCA4 STAT5A STAT3 PIK3R3 STAT5B TSLP BRWD1 IRS1 RAG2 PIK3R2 RAG1 CRLF2 CISH PIK3R1 IRS2 IL2RG H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JAK1 IL7R SOCS2 IL7 SOCS1 HGF JAK3 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants FLT3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis SLC45A2 OCA2 DCT TYRP1 TYR NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2A2 ATP6V1H CD8B;CD8B2 AP2S1 AP2A1 AP2B1 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint CDK1 PKMYT1 CCNB2 CCNB1 WEE1 CCNA2-1 CCNA1 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling CD4 NCK1 PSMD12 PSMD11 PSMD14 PSMD13 LCK EVL PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PLCG1 PSMB1 CSK PSMD1 ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 SEM1 PSMA6 PAG1 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 IKBKB IKBKG UBA52 CUL1 RPS27A UBB;UBC MAP3K7 UBE2V1 WAS GRAP2 PAK1 INPP5D LCP2 PAK3 TRAT1 UBE2N TAB2 ITK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 PDPK1 VASP FYB1 PTEN HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ENAH HLA-DRA CD3G LAT CD101 TRAF6 PIK3R2 PIK3CB PIK3R1 PIK3CA PLCG2 PTPRJ PTPN22 CDC34 PRKCQ CARD11 BCL10 MALT1 UBE2D3;UBE2D2 NFKBIA PAK2 UBE2D1 RELA PTPRC NFKB1 ZAP70 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 POLR2E NUP210 POLR2F POLR2H GTF2F1 GTF2F2 NUP93 POLR2L POLR2A NUP205 NUP42 POLR2B POLR2C AAAS POLR2D NUP160 NUP43 NUP85 POLR2G TPR NUP214 NUP88 POLR2I RAE1 RANBP2 NUP155 NUP153 POLR2J;POLR2J2;POLR2J3 NUP35 NUP62 NUP37 NDC1 SEC13 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate DCXR SORD AKR1A1 XYLB CRYL1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 E2F2 CDK6 PPP2R1A ABL1 CDKN1A CDKN1B SKP1 CDK7 CCND1 MNAT1 CKS1B JAK2 CDKN2B LYN PPP2R3B CCND3 CCND2 UBA52 PPP2R2A;PPP2R2D CDKN2D CUL1 CDKN2C PTK6 CDK4 CDK2 PPP2CB;PPP2CA E2F4-1 RPS27A E2F5 CDKN2A PPP2R1B SKP2 UBB;UBC TFDP1 RBL2 TFDP2 RBL1 CCNE2 CCNE1 RB1 CCNH CDKN1C E2F1 E2F3 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases STAT3 NR3C1 EGF ERBB2 HRAS EGFR RASA1 HIF1A NRAS CDKN1B LRRK2 ARHGAP35 SFPQ-1 RAC1 PELP1 NRG1 CCND1 NRG2 ARAP1 RHOA EREG BTC DOK1 NRG3 NRG4 ELMO1 ELMO2 CRK DOCK1 HBEGF KHDRBS1 KHDRBS2 KHDRBS3 AKT1 UBA52 EPAS1 PXN CBL SOCS3 GPNMB STAP2 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 RPS27A UBB;UBC CCNE1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template UBA7 ISG15 UBE2L6 POLK POLE TRIM25 RFC1 POLD1 PCNA UBA52 POLI POLH USP10 PCLAF USP43 RPA1 SPRTN RPA2 NPLOC4 UFD1 POLD3 POLD4 POLD2 RPA3 VCP-1 RPS27A RFC5 RFC3 RFC4 POLE4 UBB;UBC RFC2 REV1 POLE2 MAD2L2 RCHY1 REV3L POLE3 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions GJC1 GJA10 GJD2 PANX1 PANX2 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis NUP133 NUP50 HKDC1 POM121;POM121C NUP54 PGK1 PFKFB2 PFKFB1 PFKFB4 NUP42 PFKFB3 PRKACB-1 ENO1 ENO2 NUP43 ENO3 GNPDA1 ENO4 RAE1 GNPDA2 RANBP2 NUP35 ALDOC ALDOB ADPGK ALDOA NUP37 PRKACA-1 PPP2R1A NUP107 NUP188 BPGM NUP210 PGM2L1 NUP93 PFKL PGAM1 PGAM2 NUP205 PFKM AAAS PFKP GPI NUP160 NUP85 NUP214 TPR NUP88 GCKR NUP155 GCK TPI1 NUP153 PPP2CB;PPP2CA PPP2R5D GAPDH-1 HK2 PPP2R1B HK1 HK3 NUP62 GAPDHS NDC1 SEC13 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC TUBAL3 TUBA1A TUBA1C TUBB1 TUBA8 CCT3 CCT2 CCT8 TUBA3E;TUBA3C-1 CCT7 TUBB2B;TUBB2A CCT5 CCT4 TCP1 CCT6A TUBA4A TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CCT6B TUBB3;TUBB6 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures COL4A5 COL1A1 COL1A2 ITGB4 LOXL3 LOXL4 LOXL1 LOXL2 COL10A1 BMP1 COL9A1 COL27A1 COL9A3 COL9A2 COL18A1 PCOLCE LAMC2 COL2A1 CTSS LOX MMP20 COL4A2 COL4A1 COL4A4 COL6A2 PXDN COL4A3 COL6A1 COL8A2 COL8A1 COL6A3 ITGA6 COL6A6 COL6A5 CTSB CTSV;CTSL PLEC MMP7 CD151 COL11A1 COL11A2 MMP3 MMP9 COL24A1 COL3A1 COL5A1 MMP13 COL5A3 COL7A1 COL5A2 COL15A1 LAMA3 LAMB3 TLL2 TLL1 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 IRF7 UBB;UBC TBK1 TANK TLR3 IKBKE TICAM1 IRF3 OPTN-1 TRAF3 RPS27A UBA52 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E LNPEP CTSS CTSV;CTSL B2M PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis UMPS DHODH CAD DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels P2RX6 ITPR1 P2RX5 ITPR2 P2RX3 STIM1 ITPR3 P2RX2 P2RX1 ORAI2 ORAI1 P2RX7 P2RX4 TRPC7 TRPC6 TRPC3 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors P2RY6 P2RY2 LPAR4 P2RY1 GPR17 P2RY10 P2RY11 LPAR6 P2RY12 P2RY13 P2RY4 P2RY14 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste KCNJ2 TAS2R7 TAS2R8 TAS2R3-1 GRM4 SCN3A SCNN1G SCNN1D SCN2A TAS2R1 SCNN1B SCN2B TAS2R4 SCNN1A TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GRM1 CALHM1 OTOP1 TAS2R16 CALHM3 GNG13 SCN9A GNB1 TAS2R40 GNB3 TAS2R41 ITPR3 PRH1-TAS2R14;TAS2R14-3 TAS1R2 TAS1R1 TAS2R39 TAS1R3 GNAT3 TRPM5 PLCB2 SCN4B TRPM4 SCN1B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 ADAM17 DLL1 JAG2 DLL4 JAG1 ADAM10 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type MMAB DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis GLB1 CTSA NEU1 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling LAMA5 MET ITGA3 LAMA3 ITGB1 LAMA2 SRC LAMA4 ITGA2 LAMB3 LAMB2 LAMB1 LAMA1 LAMC3 LAMC2 LAMC1 PTK2 HGF REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand RPA1 RPA2 ACD TINF2 POLD3 TERF2 POLD4 DNA2 RPA3 POLD2 POT1 TERF2IP TERF1-1 FEN1 POLD1 PCNA WRN EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling ARHGEF7 EFNB2 EFNB1 EFNB3 PAK1 RAC1 GIT1 MYL12A PAK3 NCK2 FYN EPHB6 EPHB2 SDCBP EPHB1 EPHB4 PAK2 EPHB3 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling CBL SOCS3 STAT1 TYK2 IL6 PTPN11 IL6ST STAT3 JAK1 JAK2 IL6R OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency OTC SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2;SMAD3 FURIN LEFTY2;LEFTY1 CER1 FOXO3 FOXH1 SMAD4 PCSK6 TDGF1 GDF1 MAPK1 MAPK3 ACVR1B CFC1;CFC1B DAND5 ACVR1C NODAL ACVR2B DRAP1 ACVR2A DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation UHRF1 DNMT3B H2AC20 H2AB2;H2AB3;H2AB1 DNMT3A H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 DNMT1 DNMT3L H2BC5 H2BC1 H2AC14 H2BC21 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism NUP133 EIF4A3 NUP50 POM121;POM121C NUP54 KPNB1 NEDD4 NUP42 UBE2N PIN1 NUP43 RAE1 RANBP2 KPNA4-1 IRF3 NUP35 PLCG1 BECN1 IFIT1 JAK1 NUP37 EIF4A2 EIF4A1 USP18;USP41 MX1-1 NUP107 NUP188 EIF4E2 KPNA1 UBA7 EIF4E NUP210 DDX58 ISG15 UBE2L6 HERC5 NUP93 TRIM25 ARIH1 NUP205 EIF4G3 EIF4G2 EIF4E3 AAAS UBA52 NUP160 NUP85 NUP214 TPR NUP88 STAT1 NUP155 NUP153 KPNA7 KPNA5 RPS27A KPNA3 UBE2E1 KPNA2 UBB;UBC EIF2AK2 NUP62 MAPK3 FLNB EIF4G1 PPM1B NDC1 SEC13 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions CSRP1 SNCB MTF1 MT2A MT3 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) GNA13 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 ARRB1 GNB4 F2R GNB3 GNGT1 GNA12 F2 GNB5 F2RL2 F2RL3 ARRB2 MAPK1 MAPK3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines PAOX SAT1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling S100A12 HMGB1-1 PRKCSH APP SAA2;SAA1 MAPK1 MAPK3 CAPZA1 DDOST CAPZA2 LGALS3 AGER DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) PRELP OMD ACAN KERA FMOD LUM B4GALT1 OGN INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling SOS1 PIK3CA PTPN6 PTK2B IL21 PIK3R3 STAT3 IL3RA IL2RB GAB2 INPPL1 CSF2RB CSF2RA INPP5D IL5RA GRB2 SHC1-1 IL21R IL9 IL9R STAT4 JAK2 IL15 STAT1 CSF2 LCK STAT5A IL2 STAT5B IL3 SOS2 PIK3CD SYK PIK3R2 HAVCR2 PIK3CB IL5 IL2RA PIK3R1 IL2RG JAK1 LGALS9C;LGALS9;LGALS9B JAK3 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC36A4 SLC7A9 SLC7A5 SLC3A2 SLC6A12 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC7A1 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 OGG1 H2AC14 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t PGM1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters SLC22A6 SLC22A12 SLC22A8 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE ARHGEF7 SOS1 GNA13 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF PSENEN ABR RASGRF2 SQSTM1 PLEKHG2 ARHGEF33 ARHGEF37 ARHGEF38 SOS2 PSEN1 CASP2 NCSTN TRAF6 ARHGEF40 YWHAE FGD1 NGFR FGD2 FGD3 FGD4 ARHGEF26 BEX3 CASP3 PLEKHG5 MCF2 RAC1 ECT2 ARHGEF39 KALRN NET1 UBA52 NGF TIAM1 ARHGEF10L AKAP13 MCF2L ARHGEF11 AATF ARHGEF10 ARHGEF12 MAGED1 VAV3 ARHGEF15 ARHGEF17 RPS27A TRIO ARHGEF16 PSEN2 ARHGEF19 ARHGEF18 UBB;UBC ITSN1 VAV1 APH1A VAV2 APH1B TIAM2 PREX1 ARHGEF3 ITGB3BP ARHGEF4 MAPK8 ARHGEF1 ARHGEF2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 RIPK3 MYD88 NFKBIB RELA NKIRAS1 TLR3 NKIRAS2 NFKB2 CHUK TICAM1 DHX9 RIPK1 NFKB1 IKBKB IKBKG ZBP1 NFKBIA ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G4A PLAAT3 PLA2G1B PLBD1 PLA2R1 PLA2G3 PLA2G5 PLA2G10;LOC100652777 PLA2G2F PLA2G6 PLA2G2D PLA2G2E PNPLA8 TMEM86B MBOAT2 LPCAT4 LPCAT3 LPCAT2 LPCAT1 PLB1 PLA2G2A-1 PLA2G12A PLA2G4F JMJD7-PLA2G4B;PLA2G4B PLA2G4D PLA2G4E DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p ALG11 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly CDK1 TUBAL3 NUP133 RANGAP1 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 TUBA3E;TUBA3C-1 IST1 KPNB1 VPS4A SPAST CC2D1B UBE2I NUP43 SUMO1 EMD TUBA8 SIRT2 NUP35 RAN NUP37 TUBA1A PPP2R1A LBR NUP107 NUP188 RCC1 BANF1 LEMD3 NUP93 CHMP4C CHMP4B LMNB1 CHMP4A NUP205 TUBA4A PPP2R2A;PPP2R2D NUP160 AHCTF1 TNPO1 NUP85 TUBA1C TUBB1 NUP155 CCNB2 CCNB1 PPP2CB;PPP2CA CHMP2B ANKLE2 CHMP2A TUBB2B;TUBB2A NUP62 VRK1 LEMD2 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 NDC1 SEC13 TUBB3;TUBB6 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family MUC17 FCER1G MUC5B MUC20 CLEC6A MUC21 MUC12 MUC15 PLCG2 MUC3A MUC5AC SYK MUC1 FYN MUC2 LYN MUC7 CLEC4A MUC4 CLEC4D MUC6 MUC13 CLEC4E ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 FGF20 FGF23 FGFR2 FGF2 FGF7 FGF22 FGF3 FGF10 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease FRS2 GAB1 SOS1 PIK3CA PLCG1 FGFR4 HRAS PIK3R1 NRAS GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV GYG1 GYS1 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins DLGAP3 DLGAP4 STXBP1 SHANK2 STX1A SHANK1 NLGN3 NLGN1 NLGN2 EPB41 NRXN3 NRXN2 BEGAIN EPB41L5 GRIN2A EPB41L2 PDLIM5 NLGN4X;NLGN4Y HOMER1 HOMER2 SYT7 GRIN2B SYT12 GRIN1 APBA3 APBA2 APBA1 GRM1 GRM5 EPB41L1 SHANK3 SYT9 SHARPIN CASK LIN7A LIN7C GRIN2C GRIN2D DLG2 DLG3 DLG4 SYT2 SYT1 NRXN1;NRXN3;NRXN2 DBNL SYT10 LIN7B SIPA1L1 LRRTM3 LRRTM4 LRRTM1 LRRTM2 DLGAP1 HOMER3 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation COLEC10 FCN2;FCN1 MASP1 COLEC11 MBL2-1 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) TIAM1 CTNND1 FARP2 CBLL1 CDH11 SRC CTNNB1 RAC1 CTSB CTSV;CTSL RPS27A CDC42 CTNNA1 UBB;UBC CDH1 JUP VAV2 ELMO1 DOCK1 ARHGEF4 CTSS UBA52 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CD GAB1 PIK3CG PIK3CA PIK3CB EPO EPOR PIK3R1 IRS2 PIK3R5 JAK2 LYN FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis ABL1 ARPC4 ARPC5 WAS ARPC2 ARPC3 YES1 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A WASL ACTG1 CD3G CDC42 SYK FGR HCK FCGR3A;FCGR3B FYN WASF2 WASF3 BAIAP2 NCKIPSD RAC1 MYO10 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK DOCK1 LYN PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification DPM1 DPM2 DPM3 ARSD-1 ALPG;ALPP;ALPI-1 IDE BMI1 YY1 RING1 SATB1 RNF2 HDAC7 CBX8 PHC2 RAB4A PHC1 CBX4 CBX2 GCSH-3 PHC3 PNPLA2 NAGK RAB5A AMDHD2 GFPT2 GFPT1 PGM3 CETN2 GNPNAT1 UAP1 CCP110 RENBP OTUD7B ACTR1A TUBA1A TNFAIP3 USP21 USP4 BTRC CYLD APOA2 RAB8A BIRC2 APOA1 SKP1 BIRC3 CDC73 APOA5 LEO1 FBXW11 CSNK1D AXIN2 RAB14 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA CSF1 MAN2A2 MGAT3 ST8SIA6 CHST8 CAMKMT ST8SIA2 FUCA1 ST8SIA3 RPS27A UBB;UBC DYNC1H1 TUBB4B HSP90B1 TUBB4A;TUBB;TUBB8B;TUBB8 TNIP2 CDK1 LHB PRKDC TMEM129 HLTF RNF152 SHPRH PEX10 PEX2 PEX12 PEX13 PEX14 RNF40 RNF144A SELENOS WAC-1 RNF181 RAD18 INS;INS-IGF2 ADAM10 ADAMTS16 ADAMTS18 PLAUR LAMC1 ADAMTS4 ADAMTS5 GALNT2 ADAMTS1 TIMP1 ADAMTS8 ADAMTS9 FOXO4 ATXN3 OTUB2 OTUD5 OTUD7A FBXO32 VCPIP1 TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 OTUB1 FURIN SPP1 LAMB1 HK1 DBT TRAPPC2L RAB32 RAB31 TBC1D20 RAB35 H2AC14 TRIM28 RAB38 L3MBTL2 TGFA RAB6B HCFC1 TRAPPC3 TRAPPC1 SATB2 TRAPPC4 TRAPPC5 OGT-1 PPARGC1A RAB39A CREBBP RAB27A RAB39B RAB27B TRAPPC9 SMAD2;SMAD3 ADRB2 H2AC20 RAB8B TRAPPC2;TRAPPC2B RAB33A TRAPPC6A TRAPPC6B RAB7B RAB1A RAB1B RAB21 NCOA1 NCOA2 CHML GPIHBP1 TRAPPC10 ACTL6A RAB33B-1 RAB11B RAB10 RAB13 RAB18 UBE2D3-1 ARF1 NCOR2 KAT2B KAT2A SUZ12 H2BC5 SUMF2 MCRS1 PCGF2 SUMF1 H2BC1 MITF IGFBP1 EP300 MEN1 H2AC4 CLSPN DNMT1 SUDS3 CBX5 PENK ACTB-1 TADA3 CHD3 SIN3A H2BC21 PARP1 ZNF350;ZNF432 DNMT3B SRD5A3 WDR5 DNMT3A KCTD6 SMAD1 SMAD4 SMURF2 SMAD7 HDAC2 THBS1 HDAC1 ST6GALNAC5 MTA1 ST6GALNAC6 RBBP5 TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 PROS1 H2BC15;H2BC3;H2BC11;H2BC12 FGA FGG F2 NOTUM F5 F7 F8 F9 SERPINC1 KNG1 SERPIND1 F10 FUCA2 PROC EIF2AK2 TOPORS POMT2 ARSA SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ARSL ADAMTS7 ARSJ SBSPON ARSK MUC3A MUC5AC ARSH ADAMTS20 ARSI B3GLCT ST8SIA5 ADAMTS12 ARSG CFP THBS2 THSD1 CTSA THSD4 ADAMTS10 ADAMTS15 ADAMTS14 BPIFB2 MUC1 MUC2 ADAMTS19 ADAMTS17 RPL27A MUC7 MUC4 MUC6 PSMD12 GALNT3 MUC17 PSMD11 C1GALT1 PSMD14 MUC5B PSMD13 MUC20 MUC21 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 ANK3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 KDM8 AHSG PSMC3 OGFOD1 PSMA1 JMJD4 PSMC4 DHPS PSMC1 FN3KRP JMJD7 RCCD1 RAB3D EIF5A2 DNAJC24 RAB44 DPH1 DPH2 DPH5 DPH6 DPH7 ZC3H15 FN3K RAB37 RWDD1 ICMT RAB4B EIF5A;EIF5AL1 DOHH RAB24 RIOX1 DRG1 DRG2 NUP214 COPB1 CD59 CD55 HSPA8 MVD ASPH RBX1 MAT2B QSOX1 MBTPS1 POLB CTSZ RPL8 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN FCGR3A;FCGR3B SMC5 PARK7 SMC6 CUL3 DDX17 NSMCE3 FDX1 NSMCE2 NSMCE1 HIC1 EID3 ZBED1 KBTBD7 USP18;USP41 TP53BP1 SP3 C3-1 TOP2A TOP2B NUP107 ZNF131 NUP188 SENP5 FOXL2 SENP2 SAFB NSMCE4A TOP1 SP100 USP14 UHRF2 NUP210 RNF168-1 CASP8AP2 NOP58 RWDD3 MBD1 NUP93 RAD52 NUP205 UBXN1 NGLY1 MLEC AAAS ENGASE NUP160 ARRB1 NUP85 TPR NUP88 NUP155 XRCC4 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 NUP153 RCE1 NAPA RAB5C TGOLN2 CDH2 ELOC-1 NUP62 ELOB NDC1 SEC13 LIPT2 USP8 NFU1 LIPT1 NUP133 LIAS PIGS CPM LY6K PIGU GOLGB1 PGAP1 RANGAP1 PIGT NUP50 PSCA POM121;POM121C PIGO PIGN NUP54 GPAA1 PIGP PIGZ MSLN PIGW PIGV PRSS21 PRND TECTB IZUMO1R RTN4RL2 PIGC CISH PIGB NUP42 NRN1L RTN4RL1 CD109 PIGA SOCS2 LY6D PIGK NUP43 PIGM SPACA4 TAF9B PIGL PIGG RAE1 LY6H RANBP2 PIGF GPLD1 PIGH NRN1 NTM TEX101 TAF10 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 LYPD8 NUP35 ARRB2 ART4 ALB OTOA LY6G6C OPCML NTNG1 NTNG2 UBE2T NEGR1 CNTN5 NUP37 PIGX-1 LSAMP COP1 GP2 PLET1 PRSS41 XPNPEP2 LYPD6B ALPL VCAN CNTN3 MELTF GLB1 CNTN4 TECTA;TBCEL-TECTA MDGA2 RECK MDGA1 SPRN ARSB DDX58 IFIH1 TRIM25 FOLR2 IKBKG LRR1 CCNF KEAP1 HERC2 GALNT11 GALNT14 AMER1 GALNT13 GALNT16 FBXO7 GALNT15 AXIN1 FBXO9 GALNT18 B3GALNT2-2 GALNT10 POFUT2 WSB1 FBXO2 EMID1 GALNT9;GALNT17 RNF123 APC FUT10 FUT11 GALNTL5 UBE2J2 GALNTL6 B3GNTL1 GALNT9 VDAC1 GALNT8 POMGNT2 B3GNT9 SIAH2 B3GNT8 MMRN1 B3GNT6 MMRN2 CHST4 FBXL8 GCNT1 FBXL4 GCNT3 FBXL7 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 MGAT5B-1 A4GNT POMK GAN PRKN GATA3 GPR75-ASB3;ASB3-1 KLHL2 RAB2A KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 KBTBD8 SPSB4 FBXO27 UBE2Z FBXO21 FBXO22 DLAT BMP4 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 B3GNT7 B3GNT5 B3GNT4 LMO7 FBXO10 FBXO11 B3GNT3 PSME1 KLHL41 B3GNT2 SEC22B KCTD7 PSMB10 PSMB8 KLHL42 PSMB9 UBE2V2 HIF1A CUL7 CUL5 UBA6 MYC CUL2 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 ALG5 NUDT14 TGFB1 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBA3 TFAP2C UBA1 UBE2K TFAP2E;TFAP2B KBTBD13 UBE2Q2 GMPPB UBE2D1 FPGT RELA GMPPA GFUS DHRSX B4GALT2 GMDS PMM1 B4GALT3 UBE2R2 FCSK VGF DOLPP1 ALG10;ALG10B CDKN2A UBE2C ASB13 UBE2E1 ASB14 IL6 GOSR1 ASB11 UBE2S RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 ASB16 COG8 FBXL20 COG7 COG6 COG5 COG4 COG3 ASB10 COG2 SPTBN2 BET1L RAB30 RAB36 FBXL19 FBXL18 FBXL15 APOL3;APOL4;APOL1;APOL2 FBXL16 FBXL13 B4GALT6 FBXL14 CTSC FBXL12 B4GALT4 B4GALT5 ASB8 ASB9 ASB6 CAPZA3 ST6GAL1 ACTR10 ASB7 MOGS ASB4 ASB5 ASB2 RPN2 SAR1B ASB1 SDC2 RPN1 ST3GAL4 GOLGA2 DCTN6 CDC25A DCTN5 ST3GAL1 DCTN4 ST3GAL2 ST3GAL3 APP EDEM2 NFKB2 GRIA1 TOMM20 VDAC2-1 NSF SKP2 VDAC3 RPS23 MAGT1 IKBKE TOMM70 RIPK2 ANO8 AREG NFE2L2 EEF1A1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 CANX RNF135 UCHL1 SENP8 UCHL3 FOXK2 MGAT5 FOXK1 MBD5 GPC3 MBD6 ASXL1 ASXL2 MGAT1 BAP1 RPS2 MGAT2 SEC24D-1 VCP-1 TUSC3 MAP3K7 RPS6 OTULIN TMEM258 DDX5 ANK1 FUT8 MAN2A1 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CAPZB OST4 MAN1A2 MAN1C1 MAVS OSTC MAN1A1 USP30 SQSTM1 STT3A UBE2N STT3B TAB1 ST6GALNAC2 TRIM27 USP10 PRKCSH USP13 TNKS MGAT4A-1 TNKS2 RNF146 OTUD3 DDOST DAD1 TRAF3 TRAF6 ST6GALNAC1 CMAS MAN1B1 NPL ST6GALNAC3 NANP ST6GALNAC4 NEU4 BECN1 ST8SIA4 SEC23A NANS ST6GAL2 ST8SIA1 NOD1 GNE NOD2 CAPZA1 GANAB CAPZA2 VHL SEC24B SEC24A GALNT1 MGAT4C KDELR2 MGAT4B COPB2 SEC24C COPA COPE TMED3 TMED7 TMED9 COPZ2 DCAF13 HGS CALM3;CALM1 COPZ1 RAB7A ARF5 DCAF7 ARCN1 COPG2 TUBA1C COPG1 TUBB1 FBXO4 METTL21A FBXO6 KIN METTL22 ETFBKMT VCPKMT FAM86B1;EEF2KMT;FAM86B2 FBXW4 EEF1AKMT2 PSME2 EEF1AKMT1 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A FBXW7 MUL1 FBXW9 FBXW2 ARFGAP1 PREB KDELR3 TUBB3;TUBB6 PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSMD10 PSMB11 TUBA3E;TUBA3C-1 POMP PSMA8 PSMF1 PSMG3 GOSR2 PSMG4 PSMG1 PSMG2 USP5 USP3 FKBP8 MDC1 SNX3 USP37 USP34 USP47 HIF3A USP48 USP49 USP42 FBXL3 USP44 PTRH2 DAXX USP26;USP29 ARF4-1 FBXL5 USP16 WDR20 RRAGA USP24 USP25 USP20 IGFBP7 USP28 WFS1 B4GALT1 TMED2-1 CALU BARD1 SEL1L ST3GAL6 RAB6A UBXN7 SPP2 CDKN1A PDIA6 DPP3 APLP2 CHM BRCA1 SCG3 ING2 RHOA BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCC3 DDB2 GBF1 PCNA WRN EPAS1 RAB11A SOCS3 RPA1 NPLOC4 UFD1 UBA2 HIPK2 SAE1 VNN1 LTBP1 VNN2 USP7 IGFBP3 USP2 BLM MDM2-2 NPM1-2 CHRDL1 MIA2 UCHL5 MIA3 TMEM115 USP15 FSTL1 FSTL3 MDM4 DCAF8 DCAF5 DCAF6 U2AF2 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 COMMD8 COMMD9 TPGS1 TTL PUM2 DDA1 TPGS2 SVBP ANKRD9 COMMD2 ARPC4-TTLL3;TTLL3 COMMD3 TTLL12-1 AGTPBP1 COMMD1 LRRC49 COMMD6 RABGGTB NICN1 COMMD7 RABGGTA COMMD4 VASH2 SPSB3 VASH1 CCDC8 AGBL5 TTLL7 BIRC5 CUL9 AGBL4 UBD TTLL6 NAE1 TTLL5 SOCS6 SMC3 TTLL4 SOCS5 AURKB RAD21 AGBL1 WDTC1 AGBL3 CCDC22 TTLL1 DCUN1D2-1 COMMD10 AGBL2 STAG1 DTL TTLL11 TTLL9 TULP4 STAG2 SMC1A DCAF16 PML DCAF17 CAND1 FEM1C DCAF10 DCAF11 NRIP1 FEM1A TRRAP FEM1B TRAF2 NEURL2 ERCC8 JMJD6 RIPK1 CDC34 TADA2B NFRKB BCL10 ACTR5 RAD23A UBE2D3;UBE2D2 ACTR8 NFKBIA RAD23B DDB1 INO80C PRMT3 INO80B INO80E INO80D COPS7B COPS7A XPC TFPT INO80 H2AC16;H2AC11 TGFBR1-1 CUL4A COPS3 KDM1B TGFBR2 COPS6 COPS5 RUVBL1 COPS8 CUL4B PCSK9 FGF23 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L P4HB ATXN7 APOB CDC20 CCNA2-1 CCNA1 RIOX2 USP33 ETF1 H2BC18 MFGE8 USP22 CST3 SLC35C1 MUC13 JOSD2 CKAP4 JOSD1 KTN1 COL7A1 RAB3A ADAMTS13 DLST EDEM3 AMFR SYVN1 DERL2 EDEM1-1 RNF5 RNF103 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 MRTFA TF ABRAXAS2 TPST2 MYSM1 STAMBPL1 DYNC1LI1 TPST1 DYNC1LI2 STAMBP CDCA8 IL33 RHOT1 HNRNPC LRRC41 PTEN FN1 INCENP ETFB UMOD ASGR1 ASGR2 MANEA GPS1 LY6E LMAN1 STX5 YKT6 USP9X ALG8 ALG9 MCFD2 LGALS1 ALG6 AMELY;AMELX ALG2 SERPINA1 ALG3 EVA1A PPP6C PPP6R1 CCN1 ALG1 PPP6R3 CHGB IGFBP5 LMAN1L GORASP1 IGFBP4 SEC22A SEC22C SHISA5 NAPB MXRA8 TMED10 SPARCL1 STX17 LMAN2L USO1 SCG2 NAPG LMAN2 STC2 SEC31B ANKRD28 AMBN SEC23IP DHDDS TMEM132A HRC CNIH1 CRYZL2P-SEC16B;SEC16B PRSS23 BMP15-1 CNIH2 STS MEPE FOLR1 RCN1 CNIH3 ENAM BET1 AMTN VWA1 FAM20C FAM20A ITIH2 AFP GOLM1 NUCB1 TFG SPTB NEU2 NEU3 CTBP1 WDR61 NEU1 APOE HNRNPK B4GALNT2 WDR48 GAS6 ANK2 BST1 COPS4 RAB5B COPS2 SPTBN4 SPTBN5 RAB22A RAB40C RAB3B RAB3C RAB42 RAB2B RAB34 PTP4A2 RAB20 RAB25 RAB26 ARFGAP3 RAB23 RAB29 COG1 ARFGAP2 RAB15 RAB19 RAB17 SPTA1 DMP1 RNF20 ALG14 ALG12 ALG11 MATN3 NDUFAB1 TNC CFTR RFT1 LOC110384692;C4A;C4B_2;C4B SCFD1 SPTBN1 FBN1 STAM PMM2 CP SPTAN1 CALR-1 LAMB2 GGCX KDELR1 CTR9 RTF1 SEC31A PAF1 DYNC1I1 PIAS4 DERL1 HDAC4 PIAS3 DPAGT1 UBE2I THRB MPI VDR NR1H2 RORA NR3C1 RAB9A ESR1 NR2C1 PIAS1 NR3C2 RAB9B DOLK NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG DCTN1 PPARA TP53 STAM2 ST3GAL5 CGA MPDU1 FUT6;FUT5;FUT3 NUS1 SENP1 SLC17A5 PDIA3 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation HDAC1 PML KAT6A RBBP4 AKT2 AKT3 MAP2K6 ING5 BRPF1 ING2 RBBP7 MTA2 BRD1 CHD4 CHD3 MBD3 BRPF3-1 PIN1 AKT1 PIP4P1 BRD7 GATAD2B GATAD2A PIP4K2A PIP4K2B PIP4K2C EP300 MEAF6 TP53 HDAC2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway CASP3 TICAM2 DAPK1-1 TRADD DAPK2 LY96 DAPK3 FASLG TRAF2 APPL1 MAGED1 TICAM1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A UNC5A CD14 DCC FADD UNC5B TLR4 CASP9 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS SOS1 SHC1-1 EPO RAPGEF1 VAV1 HRAS EPOR IRS2 CRKL JAK2 LYN NRAS PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair TXN MSRA PCMT1 MSRB3 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 CBLIF AMN CUBN BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency ACAT1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation PPP2R1A CAMK2G MRAS MARK3 PPP1CC MAP3K11 ARAF CALM3;CALM1 RAF1 YWHAB JAK2 PPP2CB;PPP2CA SRC PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E MAP2K2;MAP2K1 HRAS BRAF PHB KSR1 SHOC2 CAMK2B CAMK2D BRAP CAMK2A PPP1CB NRAS SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors HMGB1-1 SAA2;SAA1 PRDX1 CD5L SSC5D CD36 APOB APOA1 S100A9 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors SPARC STAB1 STAB2 APOB ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding IZUMO3 IZUMO2 IZUMO4 CD9 ACR IZUMO1-1 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCG5 ABCC8 ABCC6 ABCC9 DERL3 DERL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 ABCD1 PSMB7 PSMD6 ABCB4 PSMB4 PSMD7 ERLEC1 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 ABCA12 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 ABCA1 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 APOA1 CFTR KCNJ11 ABCB6 ABCA3 UBA52 ERLIN1 ERLIN2 ABCD4 ABCB11 VCP-1 RPS27A DERL2 RNF5 UBB;UBC OS9 LMBRD1 RNF185 ABCG8 ABCC2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) S100A8 FGG TLR2 MYD88 LY96 IRAK4 BTK TLR6 S100A1 CD14 HMGB1-1 TIRAP TLR4 CD36 TLR1 FGB FGA S100A9 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes SOCS3 RUNX1 SERPINB13 CTSK SOCS4 CTSV;CTSL CBFB TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer TGIF1-1 HDAC1 SNW1 CCNK UBE2D3-1 USP9X CCNT1 NCOR2 CDK8 WWTR1 NCOR1 COL1A2 CCNC-1 NEDD4L CDKN2B SP1 UBA52 PARP1 SMAD2;SMAD3 UBE2D1 FURIN PPM1A ATP1B4 CDK9 TGIF2 SKI EP300 CCNT2-1 E2F4-1 RPS27A E2F5 SMAD4 MEN1 SMURF2 UBB;UBC SERPINE1 TFDP1 JUNB SMAD7 RNF111 TFDP2 MAPK1 RBL1 MAPK3 YBX1 SKIL MYC TRIM33 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation RPS14 RPS17 RPS16 DEPDC5 RPS19 RPS18 RPS11 RPL10A GCN1 RPS10 RPS13 RPS12 BMT2 SEH1L ATF2 WDR59 RPL27A MIOS WDR24 RRAGA RRAGC RRAGB RRAGD RPL10;RPL10L-1 RPS25 RPS27 RPS29 ASNS RPS20 RPS21 RPS24 RPS23 RPL36AL-1 CEBPG FNIP1 FNIP2 RPL7A C12orf66 ITFG2 KPTN ATP6V1E1 SZT2 ATP6V1E2 ATP6V1G1 ATP6V1G2 RPLP0 FLCN RPTOR RPLP2 RPL36-1 RPL35A RPS27L RPS15A ATP6V0D1 ATP6V0D2 ATP6V1A RPS3 UBA52 RPS2 ATF4 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPL18A FAU ATF3 RPL12-1 RPS27A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 RPS9 LAMTOR5 RPS7 RPS8 RPS5 SESN2 RPS6 TCIRG1 RPSA ATP6V0B ATP6V1B2 ATP6V0C ATP6V1B1 RPL22L1 DDIT3 SLC38A9 RPL37A-1 RPL26L1 RPL4 RPL30 ATP6V1G3 RPL3 RPL32 RHEB RPL31 RPL34 RPL8 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 RPS4X RPL35 RPL38 RPS3A MLST8 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 MTOR RPL15-1 EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPL3L RPL5-1 ATP6V1H RPLP1-2 NPRL2 NPRL3 EIF2AK4 CEBPB RPL23A TRIB3 CASTOR1 CASTOR2 SESN1 IMPACT RPL11 RPL14 SH3BP4 RPL13 RPL18 RPL17 RPL19 RPS15 SEC13 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 IL17C DUSP7 UBE2N ATF2 IL25 TAB3 TAB2 TAB1 TRAF6 NOD1 NOD2 RIPK2 JUN PPP2R1A MAPK7 IL17RC BTRC IL17RA SKP1 CHUK IL17RE FBXW11 IL17RB IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA IL17F PPP2R5D ATF1 RPS27A ELK1 IL17A RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination ATXN7 CDC20 CCNA2-1 CCNA1 IDE USP33 YY1 H2BC18 PSMD12 PSMD11 USP22 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 TOMM20 PSMB7 PSMD6 VDAC2-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 VDAC3 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 TOMM70 ADRM1 CCP110 PSMC2-1 RIPK2 PSMA2-1 PSMA5 OTUD7B SEM1 PSMA6 PSMC5 TNFAIP3 PSMA3 PSMC6 USP21 PSMA4 USP4 PSMC3 CYLD PSMA1 PSMC4 PSMC1 BIRC2 BIRC3 JOSD2 JOSD1 UCHL1 RNF135 SENP8 AXIN2 UCHL3 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 BAP1 UBA52 VCP-1 RPS27A UBB;UBC MAP3K7 TNIP2 CDK1 ABRAXAS2 MYSM1 STAMBPL1 STAMBP MAT2B IL33 RHOT1 NLRP3 POLB MAVS USP30 TAB1 USP10 USP13 TNKS TNKS2 RNF146 OTUD3 PTEN TRAF3 TRAF6 BECN1 NOD1 NOD2 USP18;USP41 USP9X FOXO4 USP14 ATXN3 HGS OTUB2 OTUD5 OTUD7A VCPIP1 TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 OTUB1 ARRB1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RCE1 MUL1 WDR48 H2AC14 USP8 HCFC1 OGT-1 USP5 USP3 FKBP8 SNX3 USP37 USP34 USP47 USP48 TAF9B USP49 USP42 USP44 PTRH2 ADRB2 SMAD2;SMAD3 USP26;USP29 USP16 WDR20 H2AC20 USP24 USP25 USP20 TAF10 USP28 ARRB2 BARD1 ACTL6A KAT2B BRCA1 KAT2A CFTR DDX58 RHOA IFIH1 BABAM1 BABAM2 TRIM25 UIMC1 ABRAXAS1 IKBKG BRCC3 STAM DDB2 H2BC5 MCRS1 H2BC1 KEAP1 UFD1 AXIN1 EP300 RNF123 APC H2AC4 CLSPN VDAC1 SIAH2 USP7 USP2 MDM2-2 SUDS3 PRKN GATA3 ACTB-1 TADA3 UCHL5 USP15 ESR1 MDM4 H2BC21 AR SMAD1 SMAD4 SMURF2 TP53 SMAD7 HIF1A MYC STAM2 TRRAP TRAF2 TGFB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIPK1 TADA2B NFRKB ACTR5 H2BC15;H2BC3;H2BC11;H2BC12 RAD23A NFKBIA ACTR8 RAD23B INO80C INO80B INO80E UBE2D1 INO80D TFPT INO80 H2AC16;H2AC11 TGFBR1-1 KDM1B TGFBR2 RUVBL1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 CDC20 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AURKB PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 AURKA ANAPC10 ANAPC11 PTTG1;PTTG2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 PLK1 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events PLA2G4A GNA14 GNA15 ADCY9 PRKAR1B GNA11 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNAQ PRKAR2A PRKCG ITPR1 ITPR2 ITPR3 CAMK4 PDE1C CAMKK1 GRK2 CAMKK2 GNAT3 GNAI1 GNAI3 GNAI2 CAMK2B CAMK2D CAMK2A PRKACA-1 CAMK2G CALM3;CALM1 GNAL PRKCD NBEA PRKCA PRKAR2B PLCB3 PLCB4 PLCB1 AHCYL1 PLCB2 KPNA2 PRKX MAPK1 PDE1B PDE1A TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA DIS3 XRN1 MAPKAPK2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A ZFP36 TNPO1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction MYL6 CALD1 CAV3 ITGB5 PAK1 MYH11 CACNA1H TRIM72 DYSF MYL12A LMOD1 CALM3;CALM1 MYL12B ANXA1 PAK2 PXN VCL ANXA2 ITGA1 MYL5 MYL7 TLN1 MYL10 TPM4 TPM3 MYLPF MYL6B ANXA6 ALDH2 MYLK SORBS1 GUCY1A2 SORBS3 PDE5A CACNA1G GUCY1A1 GUCY1B1 CACNA1I TPM2 TPM1 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling TGFA PIK3R3 GNG10 MED1 GNG2 AKT2 GNG5 NOS3 AKT3 GNG4 GNG8 GTF2A1 PTGES3-1 GTF2A2 YY1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 POLR2B POLR2C CREBBP GNB2 ATF2 POLR2D GNB1 GNB4 POLR2G KDM4B KAT5 GNB3 POLR2I GNB5 H2AC20 GPAM H2AB2;H2AB3;H2AB1 SRC POU2F1 SRF EGF GNAI1 EGFR GNAI2 NCOA1 NCOA2 PRMT1 NCOA3 JUN AREG CDKN1B KAT2B H2AJ HSP90AA1 NR5A2 EREG TLE3 BTC ZDHHC7 FOS FKBP5 CAV2 HBEGF PTK2 XPO1 H2BC5 MYB AKT1 PPP5C H2BC1 KDM1A AXIN1 EP300 ELK1 KPNA2 H2AC4 BCL2 STRN DDX5 GATA3 PRKCZ CAV1 CITED1 ESR1 SP1 H2BC21 HSP90AB1 ZDHHC21 TBP PDPK1 PGR CARM1 KCTD6 H2AZ2;H2AZ1 GNAT3 PIK3R2 ESR2 PPID HRAS GNAI3 PIK3R1 FOXA1 SMC3 FKBP4 MYC RAD21 JUND GREB1 NRAS STAG1 CXCL12 STAG2 HDAC1 SMC1A PIK3CA TFF1 KANK1 TNRC6C MOV10 CXXC5 TFF3-1 TNRC6A-1 AGO4 NRIP1 CCNT1 AGO2 USF2 USF1 CTSD AGO3;AGO1 ZNF217 FOSB TNRC6B EBAG9 FOXO3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 MMP7 POLR2E CBFB POLR2F GTF2F1 MMP2 POLR2H GTF2F2 RUNX1 MMP3 CALM3;CALM1 MMP9 S1PR3 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 IGF1R UHMK1 EPGN GNGT1 CDK9 POLR2J;POLR2J2;POLR2J3 SPHK1 MAPK1 MAPK3 H2AC14 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FGF2 PLCG1 HRAS PIK3R1 FGF1 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 GSD II%REACTOME%R-HSA-5357609.5 GSD II GAA GYG1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism IDO2 ACMSD IDO1 AFMID KYAT3 SLC36A4 SLC7A5 TDO2 KYAT1 KYNU SLC3A2 AADAT KMO HAAO EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 HSPA1A;HSPA1B NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants MARK3 ARAF RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF MAPK3 KSR1 KSR2 RAP1B NRAS APBB1IP INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling IL1RAPL1 IL1F10 MAPK8 IL1RL2 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling PTGES3-1 HSP90AB1 ARNT2 AIP ARNT AHRR AHR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination CPSF1 NCBP1 LSM10 CPSF3 LSM11 SNRPF PAPOLA SNRPB SNRPD3 SYMPK CPSF7 PABPN1-1 FIP1L1 SNRPE-2 SLBP ZNF473 CSTF3 CSTF2 NCBP2-1 CSTF2T PCF11 CPSF2-1 NUDT21 CLP1 SNRPG-2 WDR33 CPSF4 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels TSC22D3 TRDN ASPH STOM STOML3 CLCN3 CLCN2 CLCN1 BSND SGK3;C8orf44-SGK3 TPCN2 TPCN1 CLCN7 SGK1-1 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 ANO8 TRPV1 BEST2 ANO9 MCOLN1 BEST3 ANO6 TRPC4AP SLC9C2 MCOLN2 BEST1 ANO4 TRPV6 BEST4 TRPV4 TRPV5 ANO5 ANO2 ANO3 ANO1 SLC9B1 SLC9B2 SCNN1G CLCA4-1 SRI SCNN1D CALM3;CALM1 SCNN1B SCNN1A RAF1 TTYH3 TTYH2 NEDD4L ANO10 WNK4 NALCN ASIC4 UBA52 ASIC5 WWP1 CLCA2 CLCA1 ASIC2 ASIC3 ASIC1 RPS27A UBB;UBC WNK1 WNK3 RYR1 RYR2 RYR3 UNC80 CLCNKA;CLCNKB CLIC2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions PLXNC1 SEMA6A SEMA6D PLXND1 ITGA1 SEMA7A ITGB1 SEMA3E TREM2 PLXNA2 SEMA4A CD72 SEMA4D TYROBP PTPRC PLXNB3 SEMA5A PLXNA4 PLXNA1 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis DDC PNMT TH DBH REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 NQO1 PSMA1 PSMC4 PSMC1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ODC1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 OAZ1 PSMD3 PSMB1 PSMD1 ADRM1 AZIN1-2 PSMC2-1 PSMA2-1 PSMA5 SEM1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) RHOA LINGO1 ARHGDIA MAG OMG RTN4 NGFR MCF2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle MAOA STX1A SLC38A2 ARL6IP5 NAAA APBA1 GAD1 GAD2 SNAP25 GLS SLC18A3 DNAJC5 GLS2 SLC22A2 SLC22A1 SLC17A7 TSPOAP1 SLC5A7 CHAT CASK LIN7A LIN7C UNC13B SLC32A1 RAB3A SLC6A13 ABAT SYT1 SLC6A1 SYN3 VAMP2 ALDH5A1 CPLX1 SYN2 SYN1 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC6A12 SLC6A11 SLC1A1 HSPA8 SLC1A2 SLC1A3 LIN7B SLC1A6 SLC1A7 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation HDAC1 TAF1D MTA1 TAF1B RBBP4 RRN3 TAF1C KAT2B TAF1A KAT2A CDK7 POLR2E POLR2F POLR2H MNAT1 RBBP7 MTA2 MTA3 POLR2L CHD4 CHD3 MBD3 ERCC3 ERCC2 GTF2H1 GTF2H3 ERCC6 UBTF GTF2H4 GATAD2B GATAD2A TBP TTF1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 CCNH EHMT2 HDAC2 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion TFB1M MTERF4 NSUN4 TRMT10C RPUSD4 PRORP RPUSD3 TRUB2 MTERF3 RCC1L NGRN HSD17B10 MRM2 MRM3 FASTKD2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide HBA2;HBA1 CA1 AQP1 CA2 CA4 HBD;HBB RHAG SLC4A1 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling NGF CASP3 YWHAE NGFR CASP2 BEX3 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants FLT3 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair CCNA2-1 CCNA1 YY1 KDM4A PSMD12 POLI KDM4B POLH PSMD11 PSMD14 PSMD13 PSMA7 NTHL1 MUS81 PSMD8 C1orf112 EME1-1 BRCA2 PSMB6 PSMB7 RAD51AP1 PSMD6 SLX4 PSMB4 EME2 PSMD7 FIGNL1 PSMB5 GEN1 XRCC2 PSMB2 XRCC3 PSMB3 PSMD2 PALB2 PSMD3 SPIDR PSMB1 SLX1A;SLX1B PSMD1 CETN2 MPG ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 BAP1 UBA52 VCP-1 RPS27A UBB;UBC KPNA2 REV1 MAD2L2 REV3L MAPK8 RTEL1 PRKDC RBX1 ACD TINF2 TERF2 POT1 TERF2IP TERF1-1 PARG PNKP RAD18 POLB MBD4 SMUG1 NEIL2 APEX1 ADPRS UBE2N ASCC2 ASCC3 ZNF830 RAD51B USP10 PCLAF RAD51C USP43 SPRTN GPS1 MSH6 MSH3 TP53BP1 UVSSA POLQ RNF168-1 LIG1 LIG4 RAD52 ALKBH2 UBXN1 PPIE XRCC6 XRCC4 XRCC5 POLR2J;POLR2J2;POLR2J3 ALKBH3 ASCC1 FEN1 ELL BRIP1 CCNH WDR48 H2AC14 ISY1;ISY1-RAB43 MGMT COPS4 COPS2 PAXIP1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C MDC1 POLR2D POLR2G KAT5 CHEK2 SMARCA5 POLR2I CHEK1 NEIL3 NEIL1 HUS1 H2AC20 H2AB2;H2AB3;H2AB1 DCLRE1B DCLRE1A DNA2 FAAP24 RHNO1 LOC105377022;FANCB USP1 TCEA1 FAAP100 POLN CENPX SIRT6 FANCM FANCL FANCA RNF111 FANCE FANCG ATRIP FANCF UBE2T FAN1 BARD1 RAD17 ACTL6A ATM ATR BAZ1B BRCA1 H2AJ UBA7 ISG15 UBE2L6 BABAM1 BABAM2 RMI2 TRIM25 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 DDB2 APBB1 RAD51D EYA2 H2BC5 EYA3 PCNA MCRS1 EYA4 PPP5C WRN H2BC1 DCLRE1C PMS2 GTF2H1 RIF1 GTF2H3 POLL NHEJ1 GTF2H4 POLM TDP2 RPA1 HERC2 TDP1 RPA2 NPLOC4 MLH1 CDK2 UFD1 RPA3 RAD1 H2AC4 CLSPN MRE11 NBN USP7 MSH2 FANCD2 ABL1 BLM CDK7 FANCI ACTB-1 FANCC MNAT1 PIAS4 RAD51 PIAS3 FTO UBE2I ALKBH5 POLD1 PARP1 RAD9B H2BC21 EYA1 PIAS1 RAD9A SUMO1 EXO1 SUMO3 PHF6 SUMO2 H2AZ2;H2AZ1 TOPBP1 RFC5 RFC3 RFC4 TP53 RFC2 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 CENPS-CORT;CORT;CENPS RBBP8 OGG1 DTL RAD50 UBE2B TDG ERCC8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 XAB2 POLR2E POLR2F PPP4R2 POLR2H TIPIN TIMELESS PPP4C POLK POLE POLR2L NFRKB RFC1 PARP2 ACTR5 USP45 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 RAD23A ERCC3 CHD1L ACTR8 ERCC5;BIVM-ERCC5 RAD23B ERCC2 DDB1 INO80C ERCC6 INO80B INO80E INO80D XPA AQR COPS7B COPS7A XPC NSD2 POLD3 TFPT POLD4 PRPF19 POLD2 XRCC1 INO80 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 POLE2 RNF4 ERCC1 RCHY1 POLE3 RUVBL1 COPS8 CUL4B SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KANK1 GOLGA4 KDR ETV6 BIN2 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 SOS1 GABRQ GABRA1 PSENEN NEDD4 TAB2 ESR1 ADAM17 ITCH STAT5A PGR SRC PSEN1 NCSTN EGF CSN2-1 SPARC HRAS EGFR PIK3R1 MXD4 STMN1 NRAS ADAP1 CXCL12 PIK3CA NRG1 NRG2 NCOR1 EREG BTC SHC1-1 NRG3 NRG4 HBEGF WWOX UBA52 WWP1 DLG4 GABRB3 GABRB2 GABRB1 YAP1-1 RPS27A GFAP GABRG3;GABRG2 PSEN2 UBB;UBC APH1A APH1B APOE GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GAD1 GAD2 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism GBA UGCG ARSD-1 ARSL B4GALT6 ARSJ ARSK ARSH B4GALT5 ARSI ST8SIA5 ARSG CTSA ST3GAL2 ST3GAL3 B3GALT4 GALC PSAP GLA M6PR B3GNT5 GAL3ST1 HEXB UGT8 GM2A HEXA GLB1L3 GLB1L2 SMPD3 B3GALNT1 GLB1L ST6GALNAC5 GLB1 SMPD2 SMPD4 ST6GALNAC6 SMPD1 ST3GAL5 ARSB ENPP7 FUT2 FUT1 CERK SUMF2 SUMF1 STS GBA2 A4GALT NEU2 ASAH1 NEU3 ASAH2 NEU1 ARSA B4GALNT1 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death PDCD6IP UACA GZMH;GZMB-1 AKT2 AKT3 CHMP3 CHMP6 CHMP7 VIM OGT-1 SATB1 PSMD12 PSMD11 PSMD14 SFN RIPK3 TP63 PSMD13 DSG2 PPP3R1 MLKL PSMA7 PSMD8 GSDME PSMB6 PSMB7 PSMD6 CASP1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 TP53BP2 YWHAE ADRM1 ROCK1 PSMC2-1 E2F1 PSMA2-1 PSMA5 XIAP SEM1 FLOT2 PSMA6 PSMC5 PSMA3 PSMC6 DSP PSMA4 TP73 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 BIRC2 CTNNB1 BIRC3 HSP90AA1 PLEC OCLN-1 YWHAB DSG1 PTK2 AKT1 UBA52 PRKCD YWHAZ TJP1 C1QBP DAPK1-1 DAPK2 DAPK3 PKP1 SPTAN1 APPL1 DSG3 CYCS-1 RPS27A APC ADD1 UBB;UBC CDC37 CLSPN AVEN GSDMD DBNL GSN DIABLO-1 STK24 CASP9 STK26 CASP7 GAS2 BAK1 MAPT MAPK8 BCL2L11 BAD STAT3 BCL2 PMAIP1 BMF PRKN BID BBC3 BCL2L1 UNC5A PPP3CC DCC UNC5B CDH1 BCAP31 KPNB1 DNM1L BMX SDCBP CASP5;CASP4 ITCH TJP2 PPP1R13B YWHAQ YWHAH CASP6 IRF1 IRF2 APIP IL18 IL1A IL1B OPA1 APAF1 TP53 ELANE FNTA CASP3 BAX TICAM2 TRADD LY96 FASLG TRAF2 PELI1 TICAM1 KPNA1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CD14 FADD HMGB1-1 TLR4 CHMP4C CHMP4B PRKCQ CHMP4A LMNB1 DFFB DFFA HMGB2 PAK2 H1-0 H1-3 H1-2 H1-5 H1-4 ACIN1 FLOT1 MAGED1 CHMP2B NMT1 CHMP2A CDKN2A ARHGAP10 MAPK1 MAPK3 STUB1 OMA1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB-1 HADHA HADH ACADL ECHS1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins LTA4H CYP1A1 CYP1A2 ALOX15 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling CBL SOS1 PRKCA LCK PTPN6 YES1 SH2B3 SH2B2 FYN SOCS6 LYN KIT SOCS1 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes APAF1 CASP3 DIABLO-1 CASP9 CASP7 CYCS-1 XIAP CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition AKT2 AKT3 CDK7 CCNA2-1 CCNA1 MNAT1 CKS1B PSMD12 PSMD11 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 RBL2 TFDP2 PSMB1 CABLES1 PSMD1 WEE1 ADRM1 MYC PSMC2-1 E2F1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 RBBP4 PSMC4 PSMC1 SKP1 MAX CCND1 LIN54 LIN37 LIN9 LIN52 AKT1 UBA52 CUL1 PTK6 CDK4 CDK2 RPS27A E2F5 UBB;UBC CCNE2 CCNE1 RB1 CCNH VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 ELOC-1 PSMD3 PSMB1 PSMD1 ELOB ADRM1 CUL5 PSMC2-1 PSMA2-1 PSMA5 SEM1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors AVPR1B AVPR2 OXTR AVPR1A AVP OXT-1 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CEL LIPF CLPS PNLIP PNLIPRP1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species TXN P4HB TXN2 TXNRD1 SOD3 ATOX1 CCS AQP8 PRDX3 PRDX6 NCF1 NCF2 NOX4 NCF4 SOD2 SOD1 GSTP1 NOX5 CYCS-1 ATP7A GPX6 CAT ERO1A GPX5 GPX8 PRDX2 GPX7 PRDX1 CYBB CYBA NUDT2 TXNRD2 GPX1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex ORC2 CDT1 CDC6 POLE PRIM2 RPA1 PRIM1 RPA2 CDC45 MCM7 POLA1 CDK2 MCM8 POLA2 MCM3 RPA3 MCM4 MCM5 MCM6 POLE4 MCM2 MCM10 DBF4 POLE2 POLE3 GMNN ORC5 ORC4 ORC6 ORC1 CDC7 ORC3 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants SOS1 PIK3CA STAT1 PIK3R2 PIK3CB STAT3 HRAS PIK3R1 PDGFRA NRAS EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes ELANE PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly ABCA1 APOC2 APOC1 MTTP APOC4 P4HB APOA2 APOB APOA1 APOA4 A2M APOC3 PRKACB-1 APOE SAR1B ZDHHC8 PRKACA-1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA CPSF1 NCBP1 LSM10 CPSF3 LSM11 SNRPF PAPOLA SNRPB SNRPD3 SYMPK CPSF7 PABPN1-1 FIP1L1 SNRPE-2 SLBP ZNF473 CSTF3 CSTF2 NCBP2-1 CSTF2T PCF11 CPSF2-1 NUDT21 CLP1 SNRPG-2 WDR33 CPSF4 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL HADHB-1 PLA2G4A TAZ HADHA LCLAT1 PLA2G6 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation UGT1A1;UGT1A6 BLVRB ALB BLVRA SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HMOX1 ABCG2 HMOX2 FABP1 GSTA3;GSTA1 ABCC1 ABCC2 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B1;HSD3B2 LHB AKR1B15;AKR1B10 TSPO CGA TSPOAP1 HSD17B12 STARD3 HSD17B11 STARD4 CYP21A2 STARD6 STAR CYP19A1 SERPINA6 CYP11A1 POMC STS AKR1B1 SRD5A2 FDXR SRD5A1 SRD5A3 CYP11B1;CYP11B2 HSD17B3 STARD3NL CYP17A1 HSD17B1 HSD11B1 HSD17B2 HSD11B2 FDX1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 FGF20 FRS2 GAB1 SOS1 PPP2R1A FGF23 PIK3CA FLRT2 PTPN11 FLRT3 FLRT1 ANOS1-1 FGF2 FGF22 FGF3 TGFBR3 FGF10 GIPC1 FGFRL1 UBA52 CBL PPP2CB;PPP2CA RPS27A SPRED2 UBB;UBC SPRED1 PLCG1 MAPK1 HRAS PIK3R1 BRAF MAPK3 FGF1 FGF6 MKNK1 FRS3 FGF4 SPRY2 NRAS FGF9 FGF18 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER ISY1;ISY1-RAB43 RBX1 CDK7 MNAT1 POLR2A POLR2B POLD1 POLR2C POLR2D POLR2G ZNF830 POLR2I RFC5 TCEA1 RFC3 RFC4 RFC2 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 POLR2F POLR2H POLK POLE POLR2L RFC1 ERCC3 PCNA UBA52 ERCC5;BIVM-ERCC5 PPIE ERCC2 DDB1 GTF2H1 GTF2H3 ERCC6 GTF2H4 RPA1 XPA RPA2 AQR POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 PRPF19 POLD2 RPA3 RPS27A POLE4 CUL4A UBB;UBC ERCC4 POLE2 ERCC1 POLE3 CCNH CUL4B USP7 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants IL10RA PRF1 GCC2 GZMH;GZMB-1 RBX1 MDM2-2 STAT3 NPM1-2 STRN PRKAR1A MCL1 SEC31A MYH9 SQSTM1 IRF4 VCL RANBP2 STAT5A HIP1 BCL2A1 DCTN1 FN1 PPFIBP1 RRBP1 ALK IRS1 LMO7 TP53 PIK3R2 PIK3CB JUNB PLCG1 PIK3R1 CARS1 FRS2 HDAC1 JUN TYK2 PIK3CA PTPN6 TNRC6C MOV10 CDKN1A ATIC AGO4 AGO2 SKP1 EEF1G AGO3;AGO1 EIF2AK3 GRB2 IL22 EML4 CLTC UBA52 IL10 TPR CEBPB STAT1 MSN CUL1 KIF5B CCNB1 WDCP TPM4 BCL11A TPM3 RNF213-2 RPS27A TFG UBB;UBC ZC3HC1 FOXM1 ZAP70 KLC1 MAPK1 ICOS RB1 MAPK3 RPS6 MAPK9 FRS3 PPM1B DNMT1 MAPK8 BIRC6 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels GNB3 KCNJ2 GNGT1 KCNJ12;KCNJ18 KCNJ3 GNB5 KCNJ4 GABBR2 GNG10 KCNJ5 GNG2 GABBR1 GNG5 KCNJ6 GNG4 KCNJ10 GNG8 KCNJ9 KCNJ15 KCNJ16 GNG13 GNB2 GNB1 GNB4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A4 SLC39A1 SLC39A3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 ABCA3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation HDAC1 MET LEF1 CDC25B CDKN1A CCNB1 CDK2 CTNNB1 TCF7 TCF7L2 CCND1 CDKN2A TBX2 TCF7L1 HINT1 PLK1 SIN3A ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport COG4 COG3 COG2 SPTBN2 BET1L ANK2 TGFA GOLGB1 SPTBN4 SPTBN5 CTSC TRAPPC3 TRAPPC1 GOSR2 CAPZA3 ACTR10 TRAPPC4 TRAPPC5 SAR1B TRAPPC9 ARFGAP3 GOLGA2 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 SPTA1 TRAPPC2;TRAPPC2B GRIA1 TRAPPC6A NSF TMED2-1 TRAPPC6B ANK3 RAB1A RAB1B TRAPPC10 ACTR1A AREG ARF1 CSNK1D SCFD1 SPTBN1 GBF1 COL7A1 DYNC1I2 DCTN2 DCTN3 SEC24D-1 COPB1 SPTAN1 CD59 CD55 DYNC1H1 DYNC1LI1 KDELR1 DYNC1LI2 ANK1 SEC31A DYNC1I1 MIA2 MIA3 INS;INS-IGF2 CAPZB TMEM115 CTSZ DCTN1 SEC22B SEC23A CAPZA1 LMAN1 CAPZA2 SEC24B STX5 SEC24A YKT6 KDELR2 COPB2 COPA SEC24C COPE MCFD2 SERPINA1 PPP6C TMED3 PPP6R1 TMED7 PPP6R3 LMAN1L TMED9 COPZ2 GORASP1 COPZ1 SEC22A SEC22C NAPB TMED10 ARF5 STX17 LMAN2L USO1 NAPG LMAN2 SEC31B ANKRD28 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 ARCN1 COPG2 FOLR1 CNIH3 COPG1 BET1 F5 F8 NAPA TFG SPTB GOSR1 ARFGAP1 TRAPPC2L COG8 TBC1D20 COG7 PREB COG6 KDELR3 COG5 SEC13 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AEBP2 RBBP7 MTF2 PHF19 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EPOP H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC21 H2BC1 DNMT3B H2AC20 EED H2AB2;H2AB3;H2AB1 DNMT3A EZH1 H2AZ2;H2AZ1 EZH2 PHF1 H2AC4 JARID2 DNMT1 H2AC14 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth SOS1 SPTBN2 COL4A5 SPTBN4 SPTBN5 CACNA1H CACNB2 CACNB3 GFRA1 SPTA1 GDNF COL9A1 HRAS ST8SIA4 COL9A3 COL9A2 FYN CACNA1G CACNA1I NCAN NRTN COL4A2 NCAM1 COL4A1 NRAS CACNA1S COL4A4 PRNP COL6A2 PSPN GFRA2 GFRA4 COL4A3 COL6A1 ARTN CNTN2 COL6A3 COL6A6 COL6A5 SPTBN1 PTK2 SPTAN1 ST8SIA2 CACNA1D AGRN CACNA1C PTPRA RPS6KA5 SPTB MAPK1 MAPK3 CACNB1 CACNB4 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site CALR-1 CANX ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels ABCC8 KCNJ8 ABCC9 KCNJ11 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation CDK1 TYK2 PTPN11 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 DUSP4 IL6 MAP2K2;MAP2K1 DUSP6 DUSP7 MAPK1 JAK1 MAPK3 PEA15 JAK2 DUSP16 IL6R DUSP10 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors RXFP4 RXFP1 RXFP2 RXFP3 RLN3 INSL3 RLN2;RLN1 INSL5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex NCBP1 EAF1 EAF2 CTR9 RTF1 CDK7 CTDP1 PAF1 MNAT1 POLR2A SUPT6H POLR2B POLR2C POLR2D AFF4 POLR2G POLR2I MLLT1 MLLT3 IWS1 SSRP1 NCBP2-1 TCEA1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 CDC73 SUPT16H POLR2E LEO1 POLR2F GTF2F1 POLR2H GTF2F2 POLR2L ERCC3 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 ELL ELOC-1 WDR61 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis ACLY SLC27A3 OLAH SLC27A2 MORC2 SCD5 ACSL1 ELOVL1 HSD17B12 ELOVL4 ACACA ELOVL2 PPT1 ELOVL3 PPT2 ELOVL6 ELOVL7 ACSBG1 SCD ACSBG2 TECR ACSF3 HACD1 HSD17B3 ACSL6 ACSL5 CBR4 HACD3 HSD17B8 TECRL HACD2 HACD4 FASN ACSL4 ELOVL5 ACSL3 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC19A3 TPK1 THTPA SLC25A19 SLC19A2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA4 GRIA2 GRIA1 GRIA3 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends BLM CCNA2-1 CCNA1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MDC1 UBE2N H2BC21 RAD9B KAT5 CHEK1 RAD9A HUS1 EXO1 SUMO2 TOPBP1 DNA2 RHNO1 RFC5 RFC3 RFC4 RFC2 SIRT6 ATRIP UBE2V2 BARD1 RBBP8 RAD17 ATM TP53BP1 RAD50 ATR BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 PPP4R2 TIPIN TIMELESS BABAM1 PPP4C BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 UBA52 WRN H2BC1 RPA1 HERC2 RPA2 CDK2 NSD2 RPA3 RPS27A RAD1 UBB;UBC CLSPN BRIP1 MRE11 RNF4 NBN EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors PTGER1 TBXA2R LTB4R2 PTGDR GPR17 PTGIR CYSLTR1 PTGDR2 CYSLTR2 PTGER4 LTB4R PTGER2 PTGER3 PTGFR PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy TBK1 UBE2V1 UBE2D3-1 PRKN OPTN-1 MAP1LC3B2;MAP1LC3B-1 SQSTM1 UBE2N UBE2D3;UBE2D2 UBA52 TOMM20 TOMM22 VDAC2-1 MAP1LC3A RPS27A MFN1 ATG9A MFN2 ATG12-1 UBB;UBC VDAC3 TOMM40 PINK1 ATG5 MTERF3 TOMM7 VDAC1 TOMM70 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization FLT1 VEGFB VEGFC FLT4 VEGFD KDR VEGFA PGF DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells EGF AREG TGFA NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency NAGS WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 CLTB AP2A2 WNT5A ROR1 ROR2 AP2S1 FZD2 FZD5 CLTC CLTA AP2A1 AP2B1 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E ARL13B PDE6D INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) FKBP14 HERPUD1 MYDGF YIF1A HDGF DDIT3 ERN1 CREB3 DCSTAMP MBTPS1 CREB3L3 CREB3L4 SEC31A CREB3L1 GOSR2 CREB3L2 MBTPS2 CREBRF TSPYL2 DDX11 ZBTB17 SSR1 GSK3A TLN1 DNAJC3-1 DCTN1 WFS1 TPP1 HYOU1 ASNS LMNA WIPI1 CTDSP2 NFYA-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CEBPG NFYB DNAJB9 GFPT1 NFYC CUL7 JMJD7-PLA2G4B;PLA2G4B CXXC1 CXCL8 TATDN2 PDIA6 PDIA5 KLHDC3 SRPRA EIF2S2 ATF6B HSPA5 EIF2S3;EIF2S3B CCL13;CCL2 EIF2AK3 EIF2S1 SHC1-1 ATP6V0D1 ATF6 KHSRP DNAJB11 DIS3 CEBPB ATF4 PARN EXOSC7 EXTL1 EXOSC6 ACADVL CALR-1 PPP2R5B EXOSC5 IGFBP1 ATF3 EXTL2 EXOSC4 EXOSC9 EXOSC8 SYVN1 DCP2-1 EDEM1-1 EXOSC3 ADD1 EXOSC2 EXOSC1 ARFGAP1 EXTL3 SRPRB-1 PREB HSP90B1 KDELR3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state ULK3 KIF7 DZIP1 SPOPL RBX1 SMO GPR161 NUMB SPOP KIF3A IHH CSNK1A1 PTCH1 PSMD12 PSMD11 PSMD14 PSMD13 ITCH PSMA7 PSMD8 GRK2 PSMB6 PSMB7 PSMD6 SHH PSMB4 HHIP PSMD7 BOC PSMB5 SMURF2 GAS1 PSMB2 SMURF1 ARRB2 CDON PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CUL3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CDC73 DHH UBA52 ARRB1 RPS27A UBB;UBC EVC2 EFCAB7 EVC GAS8 GLI1 GLI3 GLI2 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 GNE NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways NUP133 NUP107 NUP188 NUP50 GBP2;GBP3;GBP1 POM121;POM121C NUP54 KPNA1 NUP210 ISG15 NUP93 PABPN1-1 KPNB1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 MLKL NUP153 KPNA4-1 KPNA7 KPNA5 KPNA3 NUP35 KPNA2 EIF2AK2 NUP62 NUP37 NDC1 CPSF4 SEC13 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle DBN1 TRA2B TMOD3 COPS4 SPEN ACTN1 TXNL1 COPS2 HSP90AA1 CCT7 CPSF7 VIM TWF1 MYO6 SRRM1 DDX39B CCT6A HNRNPC RBMX HSP90AB1 MSI2 ROCK2 ACTG1 CCT2 CDC37 PHIP GPS1 RBBP6 RHOBTB1 RHOBTB2 PDE5A ROCK1 CUL3 RNF20 STK38 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1A SNAP25 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK10 KCNK2 KCNK4 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 MAN1B1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway LIG1 PARG POLB POLE RFC1 PARP2 APEX1 ADPRS POLD1 PCNA PARP1 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 RFC5 RFC3 RFC4 POLE4 FEN1 RFC2 POLE2 POLE3 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant F8 F9 F10 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation ORC2 CDK1 CCNB1 MCM8 ORC5 ORC4 ORC6 ORC1 ORC3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA2-1 CHRNA7;CHRFAM7A CHRNA1 CHRNB4 CHRNA9 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT SOS1 FER PIK3CA PTPN11 PTPN6 GRB10 PIK3R3 STAT3 GRAP2 GAB2 RAC1 YES1 GRB7 MMP9 JAK2 LYN KIT SOCS1 CBL CHEK1 STAT1 PRKCA LCK STAT5A STAT5B CMA1 FES SH2B3 PIK3R2 SH2B2 VAV1 GRAP HRAS PIK3R1 FYN SOCS6 PTPRU NRAS TEC FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC1 APOBEC2 A1CF RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor DLG2 DLG3 DLG4 CAMK2G RASGRF1 RASGRF2 GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 HRAS CAMK2B CAMK2D GRIN2D CAMK2A NRAS REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription REST KCNIP3 SRF NR3C1 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type HSPG2 BCAN VCAN GPC6 CSPG5 AGRN B4GALT7 SDC1 DCN GPC1 SDC4 GPC3 SDC2 GPC2 NCAN SDC3 GPC5 BGN GPC4 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling SOS1 IL15 STAT5A STAT3 STAT5B IL2RB SOS2 GAB2 GRB2 SHC1-1 IL2RG JAK1 JAK3 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins TRIM28 NUP133 L3MBTL2 RANGAP1 NUP50 POM121;POM121C NUP54 BMI1 SATB2 RING1 NUP42 PPARGC1A MDC1 CREBBP SATB1 NUP43 RNF2 HDAC7 RAE1 RANBP2 DAXX CBX8 NFKB2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 IKBKE CETN2 NUP37 NCOA1 NCOA2 NCOR2 BRCA1 ING2 IKBKG SUZ12 PCNA PCGF2 WRN MITF NUP214 AURKA RPA1 HERC2 HIPK2 EP300 DNMT1 MRTFA BLM MDM2-2 NPM1-2 CDCA8 CBX5 DDX5 PIAS4 HDAC4 PIAS3 UBE2I HNRNPC THRB CHD3 VDR NR1H2 RORA NR3C1 ESR1 SIN3A PARP1 NR2C1 PIAS1 NR3C2 TRIM27 NR4A2 ZNF350;ZNF432 NR5A1 AR DNMT3B RXRA SUMO1 SUMO3 SUMO2 RARA PGR DNMT3A PPARG INCENP PPARA TP53 BIRC5 SMC5 PARK7 SMC6 SMC3 DDX17 AURKB NSMCE3 RAD21 NSMCE2 HDAC2 VHL NSMCE1 HIC1 STAG1 EID3 ZBED1 STAG2 HDAC1 TP53BP1 SMC1A PML SP3 TOP2A TOP2B MTA1 NUP107 ZNF131 NUP188 NRIP1 FOXL2 SAFB NSMCE4A TDG TOP1 SP100 NUP210 UHRF2 RNF168-1 CASP8AP2 NOP58 NUP93 MBD1 RAD52 NUP205 AAAS TFAP2C NUP160 NFKBIA NUP85 TFAP2E;TFAP2B TPR NUP88 NUP155 XRCC4 RELA NUP153 XPC CDKN2A CTBP1 EIF2AK2 TOPORS NUP62 HNRNPK NDC1 SEC13 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes PRKCI TRAF6 NGF UBB;UBC MYD88 IKBKB NGFR SQSTM1 RIPK2 IRAK1 RPS27A UBA52 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 NCL-1 RPS13 RPS12 NOP56 RPL27A RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 TRMT112 PELP1 RPLP2 RPL36-1 RPL35A RPS27L CSNK1D RPS15A LTV1 RRP1 FTSJ3 RPS3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 DIS3 TEX10 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 EXOSC7 WDR12 EXOSC6 BYSL RPL18A EXOSC5 BOP1 FAU EXOSC4 TSR1 RPL12-1 MTREX EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TPTEP2-CSNK1E;CSNK1E RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X SNU13 EXOSC10 RPL35 RPL38 RPS3A C1D RPP30 MPHOSPH6 RPL39 NOP2 DDX49 DDX47 RPP38 WDR3 FCF1 RPP21 RPP25 NAT10 THUMPD1 RPL21 WDR46 RPL23 WDR43 RPP14 RRP9 FBL RPL22 LOC102724159;PWP2 RPP40 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 DIMT1 RPL24 IMP3 RPL13A-1 WDR75 RPL27 IMP4 RPL26 DDX52 RPL29 UTP18 DKC1 RPL28 DDX21 NHP2 UTP25 HEATR1 TSR3 RPL15-1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPL3L RPL5-1 DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 RPLP1-2 NOL11 NOP10 RPL23A RPL11 RPL14 XRN2 RPL13 RPL18 RPL17 RPL19 RPS15 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u DPM1 DPM2 DPM3 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NGF PLCG1 NTRK1 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression REST KCNIP3 TNRC6C NPAS4 MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 SRF TNRC6B NR3C1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) IDH3A CS LYRM4 CSKMT TRAP1 SDHAF2 OGDH SUCLA2 IDH3G SDHAF3 IDH2 SDHC SDHAF1 SDHD ACAT1 SDHA SDHAF4 SDHB SIRT3 NNT ISCA2 DLD ACO2 ISCA1 FH MRPS36 DLST MDH2 SUCLG2 SUCLG1 FXN IDH3B GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis B3GALNT1 ST6GALNAC5 ST3GAL2 ST3GAL3 B3GALT4 UGCG ST6GALNAC6 ST3GAL5 B4GALT6 B4GALT5 ST8SIA5 B3GNT5 A4GALT GAL3ST1 FUT2 FUT1 B4GALNT1 CERK UGT8 FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants CBL FLT3LG UBB;UBC FLT3 RPS27A UBA52 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 CYP4F22 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation LYPLA1-1 ZDHHC21 DNM2 WASL NOSTRIN NOS3 NOSIP CYGB HSP90AA1 NMT1 SPR NMT2 CALM3;CALM1 CAV1 DDAH1 AKT1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation STOM ACTR1B CTSH B2M CTSC AGPAT2 SERPINB1 ACTR10 ITGB2 PYCARD MAGT1 RAP1B ANO6 CEP290 HSPA6 EEF1A1 HSP90AA1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 TTR RAB14 VAPA STING1 PKP1 FUCA1 VCP-1 DSC1 GSDMD TNFRSF1B DYNC1H1 TUBB4B GOLGA7-1 TUBB4A;TUBB;TUBB8B;TUBB8 DERA IST1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E APEH CAPN1 ADAM10 HSP90AB1 ADAM8 FRK CR1L;CR1 DDOST PSEN1 C3AR1 DOCK2 HBD;HBB NCSTN ELANE PTGES2 PLAUR PLAU CTSS SERPINB6-2 MGAM MMP25 PAFAH1B2 TIMP2 CHIT1 CTSG CTSD CTSB PTPRJ MMP8 RAB7A MMP9 CNN2 CHRNB4 IDH1 ITGAL CD44 FCN2;FCN1 ANXA2 MIF CCT2 TBC1D10C PRSS3;PRSS2;PRSS1 HK3 LRRC7 RAB31 LGALS3 PDXK CCT8 ALDH3B2;ALDH3B1 TRAPPC1 RAB27A PRDX6 GDI2 B4GALT1 CAT IQGAP1 RETN PECAM1 CD36 CYB5R3 RAB6A CDK13 RAB10 RAB18 FPR1 RAC1 RHOA PGAM1 P2RX1 LAMTOR2 LAMTOR1 LAMTOR3 VNN1 DBNL GSN GPR84 FABP5 ITGAV KPNB1 COMMD9 MME TRPM2 COMMD3 APAF1 ADGRE5 FPR2 ADGRE3 CAND1 TICAM2 PADI2 CD14 CD177 PTAFR LAIR1;LAIR2-1 LYZ-1 GMFG SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 MCEMP1 OSCAR HP;HPR FUCA2 PGLYRP1 CAMP OLR1 RAP1A YPEL5 DEFA6;DEFA4;DEFA5 MAPK1 TOM1 ARSA SLC11A1 ARL8A NIT2 RNASE3;RNASE2-2 ACP3 BPI S100A9 SNAP29 S100A8 SIGLEC5;SIGLEC14 LTF RNASET2 NPC2 TLR2 TMBIM1 CANT1 SELL C6orf120 CFP METTL7A-1 S100A7A;S100A7 SLPI CRISPLD2 CTSA TMEM63A SYNGR1 NBEAL2 LCN2 PSMD12 FCER1G PSMD11 CST3 PSMD14 PSMD13 RAP2B CAB39 DNAJC3-1 C1orf35 TSPAN14 PSMB7 GCA PSMD6 PSMD7 SRP14 LTA4H ENPP4 PSMD2 PSMD3 IRAG2 PSMB1 ADGRG3 PSMD1 GGH ADA2 ROCK1 MS4A3 TNFAIP6 PSMC2-1 CHI3L1 PSMA2-1 PSMA5 ATP8A1 ACAA1-1 PTX3 FRMPD3 TOLLIP DSP AHSG PLEKHO2 PSMC3 GRN ATP11B CD47 TMEM179B RAB3D ATP11A CKAP4 RAB44 LAMP1 LAMP2 KCMF1 ILF2 RAB37 RAB4B SIRPA;SIRPB1;SIRPG DSG1 FGL2 HSPA1A;HSPA1B RAB24 CPPED1 SIRPB1 KRT1 VAT1 RAB3A PRKCD CSTB SVIP C5AR1 QPCT ATP6V1D COTL1 COPB1 GSTP1 ATP6V0A1 CYFIP1 ATP8B4 CLEC12A TMEM30A SCAMP1 CD59 SERPINB3;SERPINB4-1 ITGAM CD55 PIGR HSPA8 TMC6 SERPINB10 MAPK14 SERPINB12 PKM TCIRG1 LRG1 OLFM4 PTPRB PRCP DYNC1LI1 ACLY PNP-1 VPS35L ATP6V0C SLC27A2 SURF4 IQGAP2 PRG2 PRG3 ORM2;ORM1 TYROBP QSOX1 CD53 CD63 PGRMC1 NCKAP1L CREG1 CD68 JUP MPO OSTF1 CD93 DOK3 SDCBP ARHGAP9 CTSZ TARM1 ANPEP MVP PDAP1 S100P ABCA13 HPSE ATP6AP2 NHLRC3 UNC13D SNAP25 A1BG CRACR2A PRDX4 S100A11 PA2G4 SERPINA3 ALAD PGM2 FGR NFAM1 AGA PGM1 ERP44 FCGR3A;FCGR3B SLCO4C1 GHDC EPX NRAS CLEC4D S100A12 BRI3 HVCN1 CFD C3-1 KCNAB2 SERPINA1 PTPRN2 STK11IP BST2 HMGB1-1 DNASE1L1 ATAD3A;ATAD3B DPP7 DNAJC13 CRISP3 HEBP2 CMTM6 MLEC PPIE FTH1 XRCC6 XRCC5 STK10 VAMP8 PTPRC RAB5C ASAH1 NEU1 NFASC TXNDC5 AP1M1 FTL-1 AOC1 IGF2R ARPC5 BST1 RAB5B SNAP23 CD33-1 CAP1 GYG1 ACTR2 GAA APRT AGL-1 PSAP ORMDL3 HEXB GM2A GLB1 GUSB ARSB HGSNAT CXCL2;CXCL3;CXCL1-1 PFKL CXCR1 IMPDH1 DSN1 IMPDH2 CXCR2 FAF2 ITGAX AP2A2 PPBP STBD1 SPTAN1 RHOG RHOF ATG7 DEGS1 MGST1 NDUFC2;NDUFC2-KCTD14 HUWE1 PLAC8 GLIPR1 VCL RAB9B DYNLT1 MANBA GALNS NME2 AMPD3 GLA CDA PPIA ARG1 ARMC8 ALDOC CYBB CYBA ALDOA ARHGAP45 BIN2 CPNE3 UBR4 GNS PTPN6 DGAT1 DDX3X-1 DNAJC5 HMOX2 CSNK2B CLEC5A TCN1 ALOX5 DIAPH1 PYGB PLD1 GPI PYGL MAN2B1 NFKB1 SLC44A2 LPCAT1 NAPRT SLC15A4 SLC2A5 MOSPD2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion PLCB1 PLCB2 GNA14 FFAR1 GNA15 GNAQ GNA11 PLCB3 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 FGF20 FGF23 PLCG1 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJA1 GJC1 GJB2 GJC2 GJB1 GJA3 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants FLT3 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN TBK1 NLRP4 ZBP1 IRF3 DTX4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus CNTN1 MIB2 DLL1 JAG2 PSEN1 DLL4 RPS27A PSENEN NCSTN NEURL1 PSEN2 UBB;UBC NEURL1B APH1A APH1B MIB1 NOTCH2 MDK JAG1 UBA52 ADAM10 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea KCNMB1 KCNMA1 MYH9 EPB41L1 RIPOR2 CLIC5 CIB2 PJVK EPS8 TPRN PLS1 TMC1 ESPN-1 MYO7A TMC2 MYO3B MYO3A KCNQ4 FSCN2 MYO1C EZR PCDH15 USH1C TWF1 ESPNL CDH23 OTOG CASK SPTBN1 CHRNA9 CHRNA10 XIRP2 KCNN2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX LHFPL5 OTOGL MSN TMIE USH1G STRC MYO15A SLC26A5 SPTAN1 GSN B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression DDX21 TAF1D BAZ1B TAF1B TAF1C KAT2B H2AJ TAF1A KAT2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E ACTB-1 POLR2F POLR2H GSK3B POLR2L H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 DEK SF3B1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 SMARCA5 ERCC6 MYBBP1A H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 POLR1A POLR1B POLR1C H2AC4 POLR1D POLR1E POLR1F POLR1G POLR1H H2AC14 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy TBK1 ULK1 GABARAP CHMP3 CSNK2A1;CSNK2A3 CHMP6 CHMP7 MAP1LC3B2;MAP1LC3B-1 ATG14 PRKAB2 PIK3R4 HDAC6 PRKAB1 RRAGA RRAGC RRAGB MTMR3 CETN1 TOMM20 RRAGD TOMM22 VDAC2-1 MAP1LC3A FUNDC1 ATG9A ATG12-1 ARL13B VDAC3 WIPI1 TOMM40 ATG5 MTERF3 TOMM7 TOMM70 MTMR14 PRKAG2 ATM UBE2D3-1 PRKAG1 HSF1 PRKAG3 HSP90AA1 RPTOR OPTN-1 CFTR PLIN2 UBA52 EPAS1 TSC2 TSC1 DYNC1I2 ATG3 ATG9B ATG10 ATG13 VCP-1 ATG101 RPS27A PCNT ATG16L2 LAMTOR2 ATG16L1 LAMTOR1 WDR45 UBB;UBC LAMTOR4 MAP1LC3C LAMTOR3 HSPA8 RB1CC1 LAMTOR5 WIPI2 VDAC1 ATG4C DYNC1H1 ATG7 ATG4B ATG4A ATG4D WDR45B AMBRA1 DYNC1LI1 DYNC1LI2 UBE2V1 IFT88 SLC38A9 PRKN DYNC1I1 UVRAG NBR1 RHEB PEX5 USP30 SQSTM1 UBE2N MLST8 MFN1 MFN2 PIK3C3 BECN1 PARK7 PRKAA1 MTOR CSNK2A2 PRKAA2 CSNK2B CHMP4C CHMP4B CHMP4A UBE2D3;UBE2D2 PLIN3 CHMP2B CHMP2A PINK1 GABARAPL2 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A13 SLC6A1 SLC6A12 SLC6A11 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors KIF17 CAMK2G GRIN2A GRIN2B GRIN1 APBA1 ACTN2 CASK LIN7A LIN7C GRIN2C GRIN2D GRIN3B GRIN3A DLG2 DLG3 DLG4 NBEA NEFL DLG1 LRRC7 LIN7B CAMK2B CAMK2D CAMK2A REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity HDAC1 CAMK2G LBR TNRC6C FOXG1 MOV10 TNRC6A-1 AGO4 AGO2 NCOR2 AGO3;AGO1 TNRC6B NCOR1 CALM3;CALM1 GPS2 SIN3A HTT CAMK4 HIPK2 TBL1XR1 CAMK2B AURKB CAMK2D HDAC2 CAMK2A HDAC3 PRKACA-1 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases CALM3;CALM1 SERPINB1 GSDMD CASP3 IL18 CASP5;CASP4 IL1B DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CDC20 FBXO5 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 FZR1 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants ALK ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC5A12 SLC5A8 SLC25A10 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System S100A8 TLR2 MYD88 TLR3 LY96 IRAK4 CHUK TICAM1 BTK TLR7 CD14 HMGB1-1 TIRAP TLR4 IKBKB IKBKG FGB FGA NFKBIA UNC93B1 FGG F2 RELA TLR10 NFKB2 SERPING1 F12 TRAF3 TLR6 S100A1 TLR5 NFKB1 KLKB1 CD36 TLR1 S100A9 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity RBX1 HIVEP3 GSK3B PPARGC1A PPARGC1B NR3C1 ESR1 PSMD12 MSX2 PSMD11 PSMD14 PSMD13 PSMA7 BMP2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 ESRRA PSMD7 PSMB5 PSMB2 SMURF1 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 DLX6 CBFB DLX5 UBA52 WWP1 NKX3-2 STAT1 CUL1 RPS27A UBB;UBC STUB1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 SPDL1 NUP43 RANBP2 C1orf112 NSL1 RPS27 NUP37 MAPRE1-1 PPP2R1A KNL1 ZW10 CDCA5 PDS5B PDS5A WAPL DSN1 CKAP5 RCC2 ZWINT XPO1 AHCTF1 PAFAH1B1 DYNC1I2 CCNB2 CCNB1 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E DYNC1H1 NDE1 PLK1 CDK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPO NUP160 CENPP NUP85 CENPQ CLIP1 MAD1L1 ITGB3BP SEC13 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME HPRT1 GUK1 ABCC5 NME2 GMPS ABCC4 RAC1 TPMT VAV3 NME1 SLC28A2 SLC29A1 GSTA3;GSTA5;GSTA1;GSTA2 VAV1 IMPDH1 VAV2 IMPDH2 SLC29A2 SLC28A3 GSTM1;GSTM2-1 XDH GSTA3;GSTA1 NUDT15 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins FIP1L1 STRN WDR48 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase BUB1 CLASP2 BUB1B CDC20 FBXO5 PPP1CC BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 LBR PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 CKAP5 TUBA4A XPO1 UBA52 PAFAH1B1 TNPO1 DYNC1I2 CCNB2 CCNB1 ANKLE2 RPS27A CLASP1 UBB;UBC DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CDK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 IST1 SPAST CC2D1B NUF2 KIF2A EMD NUDC KIF2C KIF2B INCENP CENPA CENPE CENPC CENPT NUP107 CENPU NUP188 RCC1 BANF1 CENPF CENPH CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A LMNB1 CENPL NUP205 CENPM CENPO PPP2R2A;PPP2R2D CENPP NUP160 NUP85 CENPQ TUBA1C TUBB1 NUP155 CHMP2B CHMP2A TUBB2B;TUBB2A CLIP1 MAD1L1 NUP62 NDC1 SEC13 TUBB3;TUBB6 TUBAL3 NUP133 NDC80 RANGAP1 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 TUBA3E;TUBA3C-1 VPS4A SPDL1 NUP43 RANBP2 TUBA8 NSL1 NUP35 RAN NUP37 KNL1 ZW10 CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 RCC2 ZWINT AHCTF1 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E VRK1 LEMD2 DYNC1I1 KPNB1 UBE2I B9D2 SPC24 SPC25 ERCC6L SUMO1 ZWILCH SIRT2 PMF1;PMF1-BGLAP KNTC1 BIRC5 SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA DLD DLST DHTKD1 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress HERPUD1 CXCL8 DDIT3 CCL13;CCL2 ATF6 KHSRP DIS3 CEBPB ATF4 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 IGFBP1 ATF3 EXOSC9 EXOSC8 DCP2-1 ASNS EXOSC3 EXOSC2 EXOSC1 NFYA-1 CEBPG NFYB NFYC UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation DLG2 DLG3 DLG4 CAMK2G GRIA2 GRIA1 GRIN2A GRIA3 GRIA4 GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 CAMK2B GRIN2C CAMK2D GRIN2D CAMK2A DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f MPDU1 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVPR1A AVP IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB IKBKG CHUK CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling CLEC4M;CD209-2 RELA PAK1 EP300 RELB PAK3 RPS6KA5 NFKB1 RAF1 HRAS FYN PRKACB-1 CREBBP LYN ICAM2 ICAM3 NRAS PAK2 PRKACA-1 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane RHOQ AKT2 RALGAPA2 RALGAPB C2CD5 SNAP23 STXBP3 STX4 PRKAB2 TBC1D1 MYH9 KIF3A TBC1D4 SFN YWHAQ PRKAB1 YWHAH RAB4A YWHAE PRKAG2 RAB10 RAB13 PRKAA2 YWHAG EXOC8 PRKAG1 RAB8A EXOC7 RAC1 PRKAG3 MYO5A MYO1C EXOC4 EXOC3 EXOC6 CALM3;CALM1 EXOC5 EXOC2 EXOC1 YWHAB RAB14 AKT1 RAB11A VAMP2 YWHAZ SLC2A4 RALA-1 KIFAP3 LNPEP KIF3B TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP3 CHMP2B CHMP6 CHMP7 CHMP2A MAP1LC3B2;MAP1LC3B-1 PIK3C3 CHMP4C CHMP4B BECN1 UVRAG CHMP4A PIK3R4 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants SOS1 PIK3CA STAT1 PIK3R2 PIK3CB STAT3 HRAS PIK3R1 PDGFRA NRAS BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins LTA4H ALOX5 ALOX15 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress ORC2 RAD17 CDC6 ATR RAD9B CHEK1 RAD9A CDC25A RPA1 HUS1 RPA2 CDC45 MCM7 CDK2 MCM8 MCM3 RPA3 MCM4 RFC5 MCM5 RFC3 RAD1 MCM6 RFC4 MCM2 RFC2 CLSPN MCM10 DBF4 ATRIP ORC5 ORC4 ORC6 ORC1 CDC7 ORC3 CDC25C TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors HSPD1 CDKN1A TGFA NPM1-2 CGA KDM5B YY1 UBE2I DEK VEGFA TFAP2A WWOX CREBBP CITED1 TFAP2C KIT CITED2 TFAP2D CITED4 KCTD1 ESR1 TFAP2E;TFAP2B KCTD15 SUMO1 ATAD2 MYBL2 NOP2 EP300 ERBB2 YEATS4 EGFR APOE MYC PITX2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence ATM RAD50 CDKN1A CDKN1B ACD HIRA EP400 TINF2 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCNA2-1 POT1 HMGA2 CCNA1 TERF2IP TERF1-1 CABIN1 LMNB1 ASF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 KAT5 UBN1 H1-0 H1-3 H1-2 H1-5 H1-4 H2AC20 CDK2 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 TP53 MRE11 CCNE2 CCNE1 RB1 NBN H2AC14 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair CCNA2-1 CCNA1 PAXIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 KDM4A PSMD12 KDM4B KAT5 POLH CHEK2 PSMD11 SMARCA5 CHEK1 PSMD14 PSMD13 HUS1 PSMA7 MUS81 PSMD8 C1orf112 EME1-1 BRCA2 PSMB6 DNA2 RAD51AP1 PSMB7 PSMD6 RHNO1 SLX4 EME2 PSMB4 PSMD7 FIGNL1 GEN1 PSMB5 XRCC2 PSMB2 XRCC3 SIRT6 PSMB3 PSMD2 PALB2 PSMD3 SPIDR PSMB1 SLX1A;SLX1B PSMD1 ATRIP ADRM1 BARD1 PSMC2-1 PSMA2-1 PSMA5 SEM1 RAD17 PSMA6 ATM PSMC5 PSMA3 PSMC6 ATR PSMA4 BAZ1B PSMC3 PSMA1 PSMC4 PSMC1 BRCA1 BABAM1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 APBB1 RAD51D EYA2 H2BC5 EYA3 BAP1 PCNA EYA4 UBA52 PPP5C WRN H2BC1 DCLRE1C RIF1 POLL NHEJ1 POLM TDP2 RPA1 HERC2 TDP1 RPA2 CDK2 RPA3 RPS27A RAD1 KPNA2 UBB;UBC CLSPN MRE11 NBN MAPK8 RTEL1 ABL1 BLM PRKDC RBX1 PIAS4 RAD51 UBE2I POLD1 UBE2N RAD9B H2BC21 PARP1 EYA1 RAD9A RAD51B RAD51C SUMO1 EXO1 PHF6 SUMO2 TOPBP1 RFC5 RFC3 RFC4 TP53 RFC2 UBE2V2 RBBP8 TP53BP1 RAD50 POLQ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 RNF168-1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLK RAD52 POLE RFC1 UBXN1 PARP2 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 DDB1 XRCC6 XRCC4 XRCC5 NSD2 POLD3 POLD4 POLD2 XRCC1 POLE4 CUL4A FEN1 BRIP1 ERCC4 POLE2 RNF4 ERCC1 POLE3 CUL4B NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle UNC13B MAOA RAB3A SYT1 VAMP2 STX1A CPLX1 SNAP25 RIMS1 PPFIA1 PPFIA4 SLC22A2 SLC18A2 SLC22A1 PPFIA3 PPFIA2 TSPOAP1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling GNAS-1 ADCY9 PRKAR2B PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKACA-1 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C CDK1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PLK1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells TET2 CBFA2T2 CXCR4 PRDM1 BMP4 POU5F1;POU5F1B NANOS3 EOMES TFAP2C NANOG;NANOGP8 PDPN SOX17 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) PSMA6 MRC1 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSME2 PSMB4 PSMD7 PSMB5 MRC2 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSME1 PSMD1 PSMB10 PSMB8 FCGR1A ADRM1 PSMB9 CD207 PSMC2-1 PSMA2-1 PSMA5 SEM1 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism UGT1A1;UGT1A6 BLVRB BLVRA COX15 ALAS2 HMOX1 ALAS1 CPOX HMOX2 ALAD ALB COX10 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UROS PPOX ABCG2 UROD HMBS FECH FABP1 GSTA3;GSTA1 ABCC1 ABCC2 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) DPF1 DPF2 DPF3 SMARCC1 SMARCC2 ACTB-1 PIWIL4 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 DNMT3L BCL7A SS18L1 H2BC21 BCL7C BCL7B SMARCA2 SMARCA4 H2AC20 H2AB2;H2AB3;H2AB1 DNMT3A H2AZ2;H2AZ1 ARID1A ARID1B C19orf84 SMARCD1 SMARCD2 SS18 HDAC2 SMARCD3 ACTL6A HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 SMARCE1 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 GATAD2B GATAD2A H2AC4 SPOCD1 SMARCB1 H2AC14 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair ISY1;ISY1-RAB43 COPS4 COPS2 YY1 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I TCEA1 RNF111 CETN2 ACTL6A DDB2 PCNA MCRS1 UBA52 GTF2H1 GTF2H3 GTF2H4 RPA1 RPA2 RPA3 RPS27A UBB;UBC USP7 RBX1 CDK7 ACTB-1 MNAT1 PIAS3 UBE2I POLD1 UBE2N PARP1 PIAS1 ZNF830 SUMO1 SUMO3 SUMO2 RFC5 RFC3 RFC4 RFC2 GPS1 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 LIG1 POLR2F POLR2H POLK POLE POLR2L NFRKB RFC1 PARP2 ACTR5 USP45 LIG3 RAD23A ERCC3 CHD1L ACTR8 PPIE ERCC5;BIVM-ERCC5 RAD23B ERCC2 DDB1 INO80C ERCC6 INO80B INO80E INO80D XPA AQR COPS7B COPS7A XPC POLD3 POLR2J;POLR2J2;POLR2J3 TFPT POLD4 PRPF19 POLD2 XRCC1 INO80 POLE4 CUL4A COPS3 COPS6 ELL COPS5 ERCC4 POLE2 ERCC1 POLE3 RUVBL1 COPS8 CCNH CUL4B FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation FGF20 FGF23 FGF2 FGF7 FGFBP1 FGFBP3 FGF22 FGF3 FGF10 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription STAT3 WWTR1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP H2BC21 LEF1 WDR5 H2AC20 IRF1 NFKB2 EED H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EZH2 ASH2L HIF1A MYC JUND MYCN JUN NFE2L2 RBBP4 TEAD1 TEAD2 RBBP5 BRD4 TEAD3 CTNNB1 H2AJ FOSB TEAD4 TCF7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L1 FOS H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 EPAS1 H2BC1 STAT1 RELA YAP1-1 ATF3 EP300 TCF7L2 H2AC4 NFKB1 KMT2A KMT2C H2AC14 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GP1BA GP5 GP9 F9 GP1BB F11 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling GPER1 ITGB1 GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 GNGT1 GNB5 PRKAR2B ITGA5 SRC GNAT3 GNAI1 GNAZ GNAI3 GNAI2 PRKACA-1 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis UBA7 ISG15 UBE2L6 POLK POLE TRIM25 RFC1 POLD1 PCNA UBA52 POLI POLH USP10 PCLAF USP43 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 RPS27A RFC5 RFC3 RFC4 POLE4 UBB;UBC RFC2 REV1 POLE2 POLE3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGL DPM2 PIGG PIGF PIGH PIGO PIGN PIGP PIGZ PIGW PIGV PIGC PIGB PIGX-1 PIGA PIGM TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 KPNA1 NUP210 NUP93 KPNB1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 HSPG2 GPC6 EXT1 EXT2 AGRN SDC1 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ATM TP63 PPP1R13B BAX TP73 PMAIP1 BID BBC3 ZNF420 AIFM2 TP53 STEAP3 TP53BP2 PRELID3A BNIP3L CREBBP PRELID1 TP53INP1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER ACTL6A RBX1 COPS4 COPS2 ACTB-1 YY1 NFRKB PARP2 ACTR5 DDB2 RAD23A MCRS1 ACTR8 UBA52 PARP1 RAD23B DDB1 INO80C INO80B INO80E INO80D COPS7B COPS7A XPC TFPT RPS27A INO80 CUL4A UBB;UBC COPS3 COPS6 GPS1 COPS5 CETN2 RUVBL1 COPS8 CUL4B METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA RPS14 RPS17 TRA2B RPS16 SNRPD2 RPS19 SNRPD1 RPS18 SNRPD3 RPS11 RPL10A RPS10 RPS13 RPS12 SNRPE-2 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 MTERF3 RPL36AL-1 PTBP1 PPP1CB HNRNPH1 HNRNPA1-1 HNRNPM PPP2R1A SUPV3L1 PNPT1 SLIRP REXO2 LRPPRC SMN2;SMN1 RPS27L CSNK1D RPS15A LTV1 RRP1 RPS3 FTSJ3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 TEX10 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 WDR12 BYSL RPL18A BOP1 FAU TSR1 RPS27A GEMIN2 UBB;UBC RPS9 RPS7 RPS8 RPS5 RPS6 RPSA ZCRB1 GEMIN4 TPTEP2-CSNK1E;CSNK1E GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX5 TCERG1 GPATCH1 PNN METTL3 CXorf56-1 FASTKD2 ZNF830 FASTKD5 SF1 TBRG4 SLBP ZNF473 DHX8 PRKRIP1 CWF19L2 RPS4X SNU13 RNPC3 HTATSF1 WDR70 RPS3A DHX35 PRPF38A SMU1 PPP1R10 DDX49 NKAP DDX47 UBL5 WDR3 FCF1 PRPF40A GCFC2 NAT10 THUMPD1 PRPF18 WDR46 SDE2 WDR43 TUT1 RRP9 FAM32A CACTIN FBL SRSF10 LOC102724159;PWP2 SRSF12 BUD23 DDX20 PRPF31 UTP14C;UTP14A PDCD7 UTP15 WDR36 EIF4A2 RBMX2 PAPOLG UTP11 SNRPG-2 EIF4A1 SNIP1 DIMT1 TUT7 SNRNP35 IMP3 WDR75 TUT4 IK PRPF4B IMP4 LENG1 DDX52 PRPF4 UTP18 DKC1 PRPF3 NHP2 SNRNP27 SNRNP25 UTP25 SNRPC HEATR1 TSR3 SNRPA NOC4L RPL15-1 PPP1R8;STX12 NOL6 ZMAT2 RRP7A ZMAT5 CCDC12 EMG1 YJU2 EIF4E PDCD11 LSM5 EIF4B BMS1 PAIP1 LSM4 DHX37 RRP36 LSM3 LSM2 UTP20 LSM8 DCAF13 NOP14 LSM7 UTP6 LSM6 UTP4 PABPN1-1 RBM25 KRR1 NSRP1-1 PNO1 PPWD1 UTP3 DDX41 RCL1 USP39 TBL3 SART1 METTL14 MPHOSPH10 SNRNP70 NOL11 NOP10 TFIP11 SYF2 PPP2R2A;PPP2R2D LUC7L3 C9orf78 WBP4 ZRSR2-1 RNF113A RBM39 PPIL2 WTAP MFAP1 ACIN1 RBM42 BUD13 HNRNPF SNRNP48 HNRNPA2B1 FAM50A SNRPA1 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM2 MRM3 XRN2 CCNH HBS1L TTC37 NT5C3B DCPS WDR82 NOP56 TP53RK SKIV2L RPL10;RPL10L-1 SNW1 RPLP0 TRMT112 PELP1 RPLP2 RPL36-1 TNKS1BP1 PRMT5 CNOT6L SF3B1 GTF2H1 GTF2H3 GTF2H4 MTREX DDX6 LSM1 PATL1 ZCCHC8 EDC3 EDC4 DCP1B TYW5 TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 NXT1 U2AF1L5;U2AF1 EIF4A3 RPL22L1 CASC3 GLE1 NXF2;NXF2B;NXF5-1 THOC1 THOC3 CDK7 THOC2 THOC5 CDC40 CNOT10 RPL37A-1 THOC7 THOC6 CNOT4 MNAT1 CNOT6 SRRM1 DDX39A DDX39B SARNP CNOT7 ZC3H11A SRSF2 CNOT11 SRSF3 SRSF5 CNOT1 SRSF6 CNOT2 SLU7 SRSF7 CNOT3 SRSF9 RBM8A RBM27 ZCCHC7 POLDIP3 CNOT8 SRSF1 RBM26 CNOT9 YTHDC1 NXF1 ZC3H4 U2AF2 FYTTD1-1 ZC3H3 DHX38 YTHDC2 SRSF11 TENT4B EXOSC10 MAGOH;MAGOHB RBM7 SRSF4-1 ZC3H18 CHTOP ZFC3H1 C1D ALYREF UPF3B DXO RNPS1 MPHOSPH6 NOP2 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 RPL13A-1 DDX21 WDR77 POLR2E SAP18 POLR2F POLR2H TRMT10C PRORP POLR2L TRNT1 HSD17B10 ERCC3 ERCC2 RPL23A GSPT2 GSPT1 UPF2 ETF1 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 GRSF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA PSMC3 PSMA1 PSMC4 PSMC1 YWHAB HSPA1A;HSPA1B HSPB1 RBMX ELAVL1 ZFP36 XPO1 KHSRP AKT1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ XRN1 MAPKAPK2 PARN ZFP36L1 EXOSC7 EXOSC6 IGF2BP3 EXOSC5 IGF2BP2 EXOSC4 RPL12-1 SET-1 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 HSPA8 PABPC1;PABPC3 MAPK14 ANP32A;ANP32D MAPK11 DCP1A EIF4G1 RAMAC LSM10 LSM11 RPL26L1 RPL4 RPL30 MTPAP RPL3 PHAX RPL32 RPL31 HNRNPC RPL34 RPL8 RPL9 RPL6 RPL7 POP5 POP7 POP1 RPL35 TSEN15 POP4 RPL38 RPP30 RTCB ZBTB8OS RPL39 TSEN2 TSEN54 CPSF2-1 RPP38 RPP21 RPP25 TSEN34 RPL21 DDX1 RPL23 RPP14 NUDT21 C2orf49 RPL22 RTRAF RPP40 XPOT FAM98B FUS RPL24 RPL27 BCAS2 RPL26 RPL29 RPL28 HNRNPA3 GPKOW YRDC CDC5L NUP107 TRMU OSGEPL1 NUP188 MTO1 TRMT61B GTPBP3 NUP210 DHX9 RPL3L GTF2F1 NOP58 GTF2F2 NUP93 SUGP1 NUP205 RPLP1-2 AAAS NUP160 NUP85 PPIE TPR PPIH NUP88 PPIG NUP155 TENT4A NUP153 SUPT5H POLR2J;POLR2J2;POLR2J3 HNRNPU HNRNPR WDR61 RPL11 NUP62 RPL14 HNRNPL HNRNPK RPL13 HNRNPD RPL18 RPL17 RPL19 WDR33 NDC1 SEC13 ISY1;ISY1-RAB43 NCBP1 NUP133 PHF5A PAPOLA TXNL4A URM1 NUP50 SNRPN WDR4 POM121;POM121C THADA LAGE3 EPRS1 NUP54 OSGEP THG1L ALKBH8 NCL-1 TRMT44 C9orf64 TRDMT1 RNMT PLRG1 PUS3 TRMT10A DNAJC8 METTL1 NSUN2 TPRKB ADAT1 POLR2A FIP1L1 TRMT1 NUP42 NSUN6 POLR2B POLR2C SNRNP40 CDKAL1 PUS7 FTSJ1 POLR2D PPIL3 ADAT3 PPIL4 TRIT1 NUP43 ADAT2 POLR2G SRRM2 QTRT1 TRMT9B POLR2I CRNKL1 DUS2 RAE1 QTRT2 RANBP2 CTU2 CTU1 TRMT6 RNGTT CSTF3 CSTF2 TRMT13 CLNS1A TRMT11 SNUPN TRMT61A NCBP2-1 HNRNPH2 NUP35 RBBP6 CWC25 RAN PPIL1-1 CWC27 CWC22 NUP37 RPL7A PRPF6 PRPF8 CPSF4 CPSF1 CPSF3 CWC15 RBM5 RPL35A IGF2BP1 PQBP1 SRRT PPP2CB;PPP2CA SNRNP200 CTNNBL1 APOBEC1 APOBEC2 ADAR ADARB1 A1CF PRCC CCAR1 TFB1M PCBP1 PAN2 PCBP2 PAN3 SYMPK RBM10 DHX15 DHX16 TGS1 SMG1 SMG9 WBP11 SMG7 SMG8 SMG5 SMG6 UPF1 DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 CSTF2T SMNDC1 U2SURP CLP1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 CPSF7 RPL5-1 CHERP PUF60 SNRPB2 AQR PRPF19 PCF11 EFTUD2 RPS15 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab CDC37 ERBB2 ERBIN HSP90AA1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants FLT3 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm SMAD2;SMAD3 LEF1 FOXA2 TEAD2 CTNNB1 YAP1-1 TEAD4 TCF7 FOXH1 SHH NOTO FOXA1 TBXT ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria SFN YWHAZ BAD PPP3R1 YWHAQ BCL2 YWHAH YWHAG AKT2 AKT3 BID PPP3CC YWHAE YWHAB AKT1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 MAMLD1 GZMH;GZMB-1 MIB2 DLL4 FCER2 HES5 PSENEN NEURL1 MIB1 JAG1 UBA52 ADAM10 CNTN1 RBPJ DLL1 JAG2 PSEN1 MAML2 EP300 MAML1 RPS27A NCSTN PSEN2 UBB;UBC NEURL1B APH1A APH1B MAML3 NOTCH2 MDK PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 RPA3 POLD2 LIG1 FEN1 POLD1 PCNA TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 SLC27A4 LCN12 APOD LCN1 SLC27A6 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity SYT2 SYT1 VAMP2 STX1A VAMP1 SNAP25 SV2C SV2B SV2A RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection CDK7 POLR2E POLR2F POLR2H GTF2F1 MNAT1 RNMT GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 RNGTT SUPT5H POLR2J;POLR2J2;POLR2J3 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation HSPG2 GPC6 HPSE IDS AGRN CTSV;CTSL SGSH SDC1 NAGLU GPC1 SDC4 GPC3 IDUA SDC2 GPC2 SDC3 GPC5 HPSE2 GPC4 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d ALG3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation FGF23 P4HB APOB APOL3;APOL4;APOL1;APOL2 MSLN BPIFB2 SDC2 MFGE8 CST3 APP DNAJC3-1 IGFBP7 WFS1 PNPLA2 ALB DMP1 CALU ANO8 VCAN MATN3 SPP2 MELTF AHSG PDIA6 TNC APLP2 APOA2 APOA1 SCG3 CKAP4 KTN1 APOA5 LOC110384692;C4A;C4B_2;C4B FBN1 GPC3 CP CSF1 IGFBP1 LAMB2 MEN1 LTBP1 IGFBP3 HSP90B1 TF CHRDL1 PENK QSOX1 MBTPS1 MIA3 FSTL1 FSTL3 ADAM10 PRKCSH MGAT4A-1 BMP4 FN1 LAMC1 C3-1 TIMP1 LGALS1 AMELY;AMELX SERPINA1 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 MXRA8 SPARCL1 SCG2 STC2 AMBN TMEM132A HRC FGA PRSS23 BMP15-1 FGG MEPE RCN1 ENAM NOTUM F5 AMTN VWA1 FAM20C FAM20A ITIH2 SERPINC1 AFP SPP1 KNG1 GOLM1 VGF SERPIND1 NUCB1 LAMB1 FUCA2 TGOLN2 PROC CDH2 IL6 APOE PCSK9 GAS6 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions CDH8 CTNND1 JUP CDH24 CDH11 CTNNB1 CTNNA1 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase VIM CDH1 BCAP31 KPNB1 DNM1L BMX SATB1 TJP2 DSG2 CASP6 FNTA ROCK1 CASP3 DSP BIRC2 CTNNB1 CASP8 KPNA1 PLEC HMGB1-1 PRKCQ OCLN-1 LMNB1 DFFB DSG1 DFFA HMGB2 PTK2 PAK2 PRKCD H1-0 H1-3 H1-2 H1-5 TJP1 H1-4 ACIN1 PKP1 SPTAN1 DSG3 APC ADD1 CLSPN DBNL GSN STK24 CASP7 STK26 GAS2 MAPT BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression ARNTL2 ARNTL NOCT HELZ2 MED1 NPAS2 BHLHE40 TGS1 CREBBP RXRA F7 CLOCK CARM1 CHD9 PPARA SERPINE1 NAMPT TBL1XR1 AVP NCOA1 NCOA2 NCOA6 SMARCD3 BHLHE41 KLF15 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling PSMD12 IL1R1 PSMD11 PSMD14 PSMD13 APP PSMA7 NFKB2 PSMD8 MAP3K3 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 TOLLIP PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 IKBKB IKBKG IL1RN IL1R2 UBA52 CUL1 RPS27A UBB;UBC MAP3K7 MAP3K8 MAP2K4 TNIP2 UBE2V1 RBX1 MAP2K6 IRAK1 IRAK2 SQSTM1 UBE2N TAB3 TAB2 TAB1 IL1A IL1B TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 TIFA HMGB1-1 IRAK3 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression SAP130 SUDS3 SAP30BP CDK7 MNAT1 BAZ2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIN3B SIN3A H2BC21 SMARCA5 UBTF DNMT3B H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 SUV39H1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 HDAC2 HDAC1 TAF1D SIRT1 TAF1B TAF1C SAP30L H2AJ TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H POLR2L H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 MBD2 H2BC1 ERCC2 GTF2H1 GTF2H3 GTF2H4 ARID4B TTF1 H2AC4 SAP30 CCNH DNMT1 RRP8 H2AC14 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins CTNND1 TNRC6C MOV10 TNRC6A-1 AGO4 SNAI1 AGO2 CDH11 CTNNB1 AGO3;AGO1 TNRC6B ADAM33 CTNNA1 CDH8 JUP ADAM19 ANGPTL4 CDH24 SP1 SOX10 CDH19 PRDM8 HEYL ILF3 FOXF1 BHLHE22 HOXC8 ZC3H12A ZEB2 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers MARK3 AKT2 AKT3 FXR1-1 DLL4 PPP1CC NEURL1 HDAC11 IRF4 HDAC5 AGK HDAC9 HDAC6 HDAC7 STAT5A STAT5B EGF ERBB2 PLCG1 EGFR PDGFRA FGF6 CARS1 AKAP9-1 PPP1CB RAP1B ESRP1 HGF GAB1 MET PPP2R1A TYK2 AREG MIB2 SKP1 EEF1G HSP90AA1 FGF7 FGF22 FGF3 FGF10 WNT3A UBA52 TSC2 STAT1 CUL1 KIF5B CCNB1 VCP-1 RPS27A UBB;UBC KLC1 CASP9 RPS6 MAPK9 MAPK8 CEP43 BCL2L11 BAD STAT3 BCL2L1 HEY1 SQSTM1 HEY2 JAK2 FLT3 ADAM10 GSK3A ADAM17 TNKS TNKS2 PDPK1 PSEN1 NCSTN PTPN11 FOXO4 FOXO3 CALM3;CALM1 IL10 MSN RB1 TGFA YES1 FOXO1-1 DUSP6 CCNC-1 DUSP7 MYH9 CREBBP IHH SMAD2;SMAD3 MAML2 MAML1 IQGAP1 MAPKAP1 JUNB MAML3 SEL1L JUN SNW1 MAMLD1 CDKN1A CDKN1B NCOR2 KAT2B RAC1 KAT2A NRG1 NCOR1 NRG2 EREG BTC NRG3 NRG4 HBEGF CBL RICTOR NTF3 ITGA2B EP300 PSEN2 APH1A APH1B TBL1XR1 DNMT1 MDM2-2 NPM1-2 CDK8 PSENEN GSK3B PRR5 MLST8 SMAD4 PIK3CD PIK3CG ESR2 NR4A1 CAMK2B CAMK2D HDAC2 CAMK2A HDAC3 HDAC1 HES1 CAMK2G MTOR KANK1 HDAC10 POLR2E POLR2F POLR2H SHC1-1 POLR2L ITGB3 LYN FGB FGA NTRK2 BDNF FGG TGFBR1-1 TGFBR2 MAP2K2;MAP2K1 RAP1A MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 GZMH;GZMB-1 PIK3R3 PIK3R6 PIK3R5 KDM7A HDAC8 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATIC PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 RAF1 YWHAB KIT NTRK3 AKT1 VWF SYVN1 DERL2 OS9 BCR FLT3LG PDGFB CD19 RBX1 CD28 STRN GAB2 PRKAR1A CD86 KLB CD80 PDGFRB FGF19 FGFR4 AKT1S1 TRAT1 RPS6KB2 PIK3AP1 CSNK1A1 CLCN6 FGFR1OP2 ZC3HAV1 JAG2 PTEN FN1 FKBP1A PPFIBP1 SHH DUSP8 DUSP9 SPRED3 SPRED2 NEURL1B SPRED1 HHAT HRAS FYN NRAS KIAA1549 NF1 KDR TRIM24 GTF2F1 GTF2F2 GRB2 IL22 AGTRAP CNKSR2 CNKSR1 AGGF1 PEBP1 EPGN ARRB1 TPR TENT4A MYO18A ETV6 WDCP AP3B1 TPM4 TPM3 POLR2J;POLR2J2;POLR2J3 TFG CLIP1 CTBP2 CTBP1 ICOS WDR48 APBB1IP NCBP1 IL10RA GOLGB1 FAM114A2 MCL1 MAP3K11 POLR2A FIP1L1 IRS2 POLR2B POLR2C POLR2D POLR2G POLR2I LCK RANBP2 TLN1 SRC HIP1 FZD5 FZD4 NCBP2-1 FZD6 FZD8 LMNA ARRB2 CSK CPSF6 FGFR3 FGFR2 FGFR1 CHUK TRIP11 EIF2AK3 HES5 ARAF MPRIP SND1 SPTBN1 EML4 DHH CLTC ERLIN2 NOX4 AMER1 PPP2CB;PPP2CA HEYL AXIN1 PPP2R5B PIM1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG APC PORCN PPP2R5E QKI CDC37 ZC3HC1 ERBIN VAV1 FOXM1 ATG7 PHB KSR1 KSR2 PPM1B BIRC6 LRP5 LRP6 PRF1 GCC2 TRAK1 FGF2 SEC31A HDAC4 MIB1 JAG1 ESR1 VCL LRRFIP1 BCL2A1 DCTN1 RRBP1 ALK ERLEC1 IRS1 TP53 LMO7 PIK3R2 PIK3CB FAM131B DKK1 PIK3R1 DKK2 DKK4 BIN2 MYC BRAP FRS2 PIK3CA MRAS PTPN6 TNRC6C MOV10 AGO4 AGO2 AGO3;AGO1 TGFB1 KRAS RNF43 BAG4 DUSP16 DUSP10 CEBPB PTPN12 GOLGA4 BCL11A TCF7L2 RNF213-2 ZMYM2 KREMEN1 KREMEN2 PAPSS1 ZAP70 CUX1 SHOC2 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin INHBB INHBA FSTL3 FST COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNA14 GNG10 CSNK2A2 GNA15 GNG2 GNG5 GNG4 GNA11 CSNK2A1;CSNK2A3 GNG8 CCT8 CCT7 CSNK2B CCT5 CCT4 GNG13 CCT6A GNAQ GNB2 GNB1 PDCL CCT6B GNB4 GNB3 GNGT1 GNB5 RGS11 RGS9 RGS6 RGS7 CCT3 CCT2 TCP1 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo STK4 STK3 LATS1 TJP2 LATS2 CASP3 TJP1 WWC1 YAP1-1 WWTR1 YWHAE YWHAB AMOTL2 AMOTL1 SAV1 MOB1A;MOB1B DVL2 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation ITGB1 BMP10 ITGB5 ITGB8 EFEMP2 EFEMP1 ITGAV ITGB6 TGFB1 FBN2 FBN3 VTN FBLN1 FBLN2 FBLN5 ITGB3 BMP7 FBN1 FURIN BMP4 BMP2 ITGA5 LOXL3 MFAP5 ITGA8 LOXL4 MFAP4 MFAP3 LTBP4 MFAP2 LTBP2 LOXL1 LTBP3 LOXL2 LTBP1 TGFB2 TGFB3 GDF5 LOX MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 LYRM4 FDXR GLRX5 HSCB SLC25A28 FDX1 SLC25A37 FXN NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 CXCL12 NRG1 NRG2 NCOR1 PSENEN EREG BTC NRG3 NRG4 HBEGF WWOX TAB2 ESR1 ADAM17 STAT5A SRC PSEN1 PGR YAP1-1 NCSTN GFAP PSEN2 CSN2-1 APH1A SPARC APH1B APOE MXD4 STMN1 ADAP1 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration RUNX3 ITGA4 SPP1 ITGAL CBFB CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression ACLY ACACB ACACA FASN MLX AGPAT1 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling N4BP1 USP18;USP41 IKBIP TRAF2 CHUK LRRC14 CASP8 USP14 RPS27A NLRC5 TRAF6 TP53 UBB;UBC IKBKB IKBKG NLRX1 UBA52 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK14 MAPK11 MAPK3 FOS MAPK9 MAPK8 ATF2 MAPK10 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 PER2 PER1 CRY2 CRY1 FBXW11 UBA52 PSMD12 PSMD11 PSMD14 FBXL3 PSMD13 CUL1 UBE2D1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells EPHA5 EPHA7 EPHA6 EPHA8 EPHA1 EPHA3 RAC1 EPHA10 YES1 PSENEN MMP2 MMP9 EPHA2 CLTC LYN CLTA AP2A1 ADAM10 AP2B1 TIAM1 AP2A2 DNM1 EFNA5 EFNA4 AP2S1 EFNB2 EFNB1 EFNB3 EFNA1 PSEN1 EFNA3 EFNA2 VAV3 NCSTN PSEN2 CLTB APH1A APH1B VAV2 FYN EPHA4 EPHB6 CLTCL1 EPHB2 EPHB1 EPHB4 EPHB3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PTGIS CYP8B1 TBXAS1 PTGDS CBR1-1 PTGS1 HPGDS PTGES3-1 HPGD PTGS2-2 PRXL2B PTGES2 PTGES PTGR2 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation NCBP1 TRA2B PHF5A SNRPD2 PAPOLA SNRPD1 SNRPN SNRPD3 DNAJC8 POLR2A FIP1L1 POLR2B POLR2C POLR2D SRRM2 POLR2G SNRPE-2 POLR2I CSTF3 CSTF2 NCBP2-1 HNRNPH2 RBBP6 PTBP1 PPP1CB HNRNPH1 CPSF4 HNRNPA1-1 CPSF1 CPSF3 HNRNPM PPP1CA RBM5 SF3B1 RBMX UBA52 SRRT RPS27A UBB;UBC SNRPF U2AF1L5;U2AF1 CCAR1 SNRPB DDX5 PCBP1 PCBP2 SYMPK CDC40 RBM10 DHX15 SRSF2 SRSF3 SRSF5 HNRNPC SRSF6 TCERG1 SRSF7 SRSF9 SRSF1 U2AF2 DDX46 DDX42 SRSF11 RBM17 SRSF4-1 HTATSF1 PPP1R10 CSTF2T CPSF2-1 PRPF40A SMNDC1 U2SURP TUT1 NUDT21 CLP1 SRSF10 SRSF12 YBX1 FUS PAPOLG SNRPG-2 HNRNPA3 SF3B4 SF3B5 SNRPC SF3B2 SNRPA SF3B3 PPP1R8;STX12 SF3B6 SF3A3 SF3A1 SF3A2 POLR2E DHX9 CPSF7 POLR2F GTF2F1 POLR2H GTF2F2 SUGP1 RBM25 PABPN1-1 POLR2L CHERP SNRNP70 PUF60 RBM39 SNRPB2 HNRNPF POLR2J;POLR2J2;POLR2J3 HNRNPA2B1 HNRNPU HNRNPR SNRPA1 PCF11 HNRNPL XRN2 HNRNPK HNRNPD WDR33 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events TRIM28 NUP133 DYNC1LI1 DYNC1LI2 ITGB1 NUP50 POM121;POM121C NUP54 DYNC1I1 H2BC18 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP43 H2BC21 RAE1 RANBP2 DAXX H2AC20 EED EZH2 NUP35 CBX1 EGFR NUP37 HDAC3 PML NUP107 NUP188 RBBP4 NCOR2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 NCOR1 RBBP7 NUP93 NUP205 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 AAAS SUZ12 H2BC5 NUP160 NUP85 H2BC1 NUP214 DYNC1I2 TPR NUP88 NUP155 NUP153 ELK1 H2AC16;H2AC11 H2AC4 NFKB1 NUP62 TBL1XR1 DYNC1H1 NDC1 H2AC14 SEC13 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib CDC37 ERBB2 ERBIN HSP90AA1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions LCK PTPN6 PTPN11 PECAM1 PLCG1 ITGB3 FYN LYN INPP5D ITGAV YES1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle UNC13B RAB3A SYT1 SLC38A2 VAMP2 STX1A CPLX1 ARL6IP5 SNAP25 RIMS1 PPFIA1 PPFIA4 GLS2 PPFIA3 PPFIA2 SLC17A7 GLS TSPOAP1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 GGCX F9 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B1;CYP11B2 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation SYK FGR HCK FCGR3A;FCGR3B FYN FCGR1A LYN YES1 CD3G PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism TAT ASRGL1 KYAT1 HPD GSTZ1 PAH QDPR HGD FAH PCBD1 IL4I1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification AAMP PLA2G4A GNA13 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 GNGT1 TBXA2R P2RY1 GNB5 P2RY12 GNAT3 GNAI1 GNAI3 GNAI2 MAPK14 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate TREH CHIT1 AMY1A;AMY1C;AMY1B;AMY2A;AMY2B SI LCT MGAM GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation KCNJ2 KCNJ12;KCNJ18 KCNJ3 KCNJ4 GNG10 GABBR2 GNG2 KCNJ5 GNG5 GABBR1 ADCY9 GNG4 KCNJ6 KCNJ10 GNG8 KCNJ9 ADCY4 ADCY3 KCNJ15 KCNJ16 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 GNB2 GNB1 GNAL GNB4 GNB3 GNGT1 GNB5 GNAT3 GNAI1 GNAI3 GNAI2 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA DBT BCKDHB MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling GAB1 MET ARF6 RAB4B CRK RAB4A CRKL GGA3 HGF RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription RUNX3 TP53 SMAD2;SMAD3 ZFHX3 CDKN1A TGFB1 SMAD4 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking COG4 GJA1 COG3 PLA2G4A COG2 SPTBN2 BET1L RAB30 RAB36 AKT2 AKT3 CTSC GJC1 ALPG;ALPP;ALPI-1 GJC2 GJA3 MAP1LC3B2;MAP1LC3B-1 AGPAT3 GJA10 CAPZA3 GJA5 STXBP3 ACTR10 GJA4 STX4 GJA9 GJA8 GJD2 GJD4 SAR1B GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GOLGA2 SFN DCTN6 DCTN5 DCTN4 APP RAB4A GRIA1 M6PR SYNJ2 NSF SCARB2 SYNJ1 AGFG1 EGF STON1-GTF2A1L KIAA0319 RAB5A EGFR TOR1A TOR1B YWHAE SYT9 SYT8 SNAP91 STON2 PIK3C2A SLC2A8 SLC18A3 SGIP1 EPN2 VAMP4 ACTR1A FCHO1 FCHO2 UBQLN1 REPS2 AREG REPS1 UBQLN2 NECAP2 EPS15 SYT11 YWHAG RAB8A MYO5A OPTN-1 MYO1C CSNK1D RAB14 UBA52 PAFAH1B1 TSC2 AP4M1 DYNC1I2 TSC1 AP1G2 DCTN2 DNASE2 DCTN3 CLVS2 SEC24D-1 AP4S1 CLVS1 TJP1 KIF5B KIF5A MAN2A2 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A RPS27A KIF20B UBB;UBC KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C KIF18A KIF18B ANK1 KIF12 MAN2A1 KIF11 KIF15 INS;INS-IGF2 KIF19 CAPZB KIF13B MAN1A2 KIF1C MAN1C1 KIF1B MAN1A1 KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 YWHAQ KIFC1 YWHAH KIF2C KIF2B CENPE SEC23A KIF26A CAPZA1 KIF26B CAPZA2 USP6NL BICD1 SEC24B SCOC BICD2 SEC24A SYS1 GALNT2 PAFAH1B3 GCC1 GALNT1 PAFAH1B2 GOLGA1 ARFIP2 RINT1 KDELR2 VPS45 COPB2 SEC24C COPA ARL1 COPE USE1 RABEPK TMED3 TMED7 NAA30 TMED9 COPZ2 HGS COPZ1 CALM3;CALM1 NAA35 RAB7A NAA38 ARF5 NBAS TMF1 STX18 STX10 ARFRP1 VPS51 VPS53 VPS52 BNIP1 VPS54 ARCN1 COPG2 COPG1 RALA-1 VAMP7 DENND5B RABGEF1 RINL TBC1D10C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A ARFGAP1 TBC1D10B GABARAPL2 TRAPPC2L SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 TBC1D7;TBC1D7-LOC100130357 PREB RAB35 KDELR3 TBC1D24 TBC1D25 DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 TGFA RIN2 GABARAP TBC1D13 TBC1D14 TBC1D17 RAB6B CCZ1;CCZ1B TBC1D15 TBC1D16 TRAPPC3 TRAPPC1 GOSR2 ANKRD27 DENND4B DENND4A TRAPPC4 TRAPPC5 DENND4C HPS1 RAB39A HPS4 MYH9 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 CHRM2 MON1A MON1B DENND1C DENND1B ADRB2 GDI1 DENND1A ARF4-1 PRKAB1 GDI2 RAB8B DENND2D DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 RAB33A TRAPPC6A TBC1D2 TMED2-1 RABEP1 TRAPPC6B RAB7B RAB3IP ARF6 RAB1A RABGAP1 RAB1B RAB21 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB6A RAB33B-1 RAB11B RGP1 RAB10 RAB13 RAB18 RAB3GAP2 ARF1 RAB3GAP1 EXOC8 PRKAG1 EXOC7 CHM RAC1 PRKAG3 EXOC4 EXOC3 EREG EXOC6 BTC EXOC5 EXOC2 EXOC1 HBEGF GBF1 RAB11A CBL VAMP2 BIN1 SNX18-1 GJB2 RALGAPA2 GJB1 RALGAPB C2CD5 MIA2 MIA3 AMPH PACSIN2 PACSIN3 PACSIN1 TMEM115 TBC1D1 TBC1D4 GRK3 AGTR1 LRP2 TACR1 F5 SLC2A4 COPS7B F8 COPS7A COPS3 COPS6 COPS5 COPS8 SNAP29 APOB CD4 PRKAB2 WASL GRK2 PIP5K1C ANK3 IL7R VPS36 SNF8 EPS15L1 VPS25 EPN1 PRKAG2 SBF1 SBF2 CPD YWHAB PICALM COL7A1 AKT1 RAB3A SYT1 YWHAZ COPB1 ITSN2 CD59 CD55 TFRC ITSN1 HSPA8 FNBP1L FNBP1 TF DYNC1LI1 DYNC1LI2 SURF4 MYO6 KIF3A CTSZ ARPC1A CD3G VAMP3 GPS1 LMAN1 STX5 YKT6 PRKAA2 MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB CHMP4C CHMP4B TMED10 STX17 CHMP4A VPS28 LMAN2L USO1 NAPG TSG101 LMAN2 SEC31B ANKRD28 SEC23IP EPGN CNIH1 AP4E1 ARRB1 CRYZL2P-SEC16B;SEC16B CLINT1 CNIH2 AP1G1 FOLR1 CNIH3 FTH1 SYT2 AP1S2 BET1 AP1S1 LDLRAP1 AP1S3 SH3D19 TPD52 VTA1 AP1B1 AP3B1 AP3S2;AP3S1 VAMP8 GAK CHMP2B DNAJC6 NAPA RAB5C CHMP2A TGOLN2 TFG BLOC1S4 BLOC1S6 SPTB SNX2 BLOC1S1 BLOC1S3 RHOBTB3 SNX9 AP1M2 SNX5 TXNDC5 AP1M1 TBC1D8B FTL-1 SNAPIN DVL2 SORT1 HIP1R SEC13 DTNBP1 TPD52L1 PUM1 VPS37C AP4B1 ARPC4 VPS37D IGF2R ARPC5 VPS37A NECAP1 ANK2 VPS37B GOLGB1 COPS4 YIPF6 ACBD3 ARPC2 ARPC3 CHMP3 RAB5B COPS2 SPTBN4 SPTBN5 CHMP6 CHMP7 CHMP5 AVPR2 SNAP23 VPS4B VPS4A MVB12B ACTR2 MVB12A ARFGAP3 COG1 ARFGAP2 WNT5A SPTA1 HIP1 FZD4 UBAP1 CLTB ARRB2 DAB2 CLTCL1 ZW10 TRIP11 CFTR SCFD1 SPTBN1 STAM CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 SPTAN1 CTTN LNPEP KDELR1 RHOQ GCC2 SEC31A DYNC1I1 SH3GL3 SH3GL1 TRIP10 RAB9A RAB9B CD3D DCTN1 SEC22B STAM2 GNS OCRL PLA2G6 ACTR3-1 GOLGA4 PLIN3 SH3KBP1 STX16 GOSR1 GOLIM4 CYTH3 CYTH2 GOLGA5 AVP ALS2 LDLR CYTH4 STX6 CUX1 VTI1A CYTH1 COG8 COG7 COG6 COG5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins TBK1 PTK2B IL21 S1PR1 VIM TNF STX4 IL4R IL13 VCAM1 IRF4 CCL3L1;CCL3L3;CCL3;CCL18 ITGB2 POMC STAT6 APP STAT5A STAT5B NFKB2 POU2F1 CASP1 SDC1 BATF IL4 IL5 JAK1 RIPK2 RAP1B PRKACA-1 HGF PPP2R1A TYK2 IL17RC TNFRSF1A BTRC IL17RA SKP1 HSP90AA1 CANX FBXW11 SOX2 UBA52 STAT1 STAT2 CUL1 CSF1 IL17F ATF1 RPS27A ELK1 IL17A RPS6KA3 RPS6KA5 RPS6KA2 UBB;UBC MAP3K7 RPS6KA1 GSDMD MAP3K8 MEF2A MAP2K3 TNFRSF1B MAP2K4 MEF2C MAPKAPK3 MAPK9 MAPK8 MAP2K7 HSP90B1 MAPK10 TNIP2 UBE2V1 STAT3 BCL2 BCL2L1 IRAK1 IRAK2 COL1A2 IL9 IL9R SQSTM1 JAK2 UBE2N TAB3 TAB2 TAB1 IL23R IL23A IL18 IL1A CDC42 IL1B TRAF6 RORC NOD1 NOD2 CAPZA1 PTPN11 CASP3 CTSG TIMP1 PTPN7 IL34 FOXO3 ALOX15 MMP1 NOS2 MMP2 MMP3 MMP9 PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 LAMA5 ANXA2 MSN MIF RALA-1 SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 IL2RA TCP1 PTPN4 YES1 DUSP4 FOXO1-1 DUSP3 VRK3 DUSP6 DUSP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VEGFA ATF2 SMAD2;SMAD3 SMARCA4 IL2 IL3 JUNB CD36 JUN MAPK7 CDKN1A ARF1 RPLP0 FPR1 CRK FOS CBL SOCS3 VAMP2 CSF2 MAP2K6 FCER2 OPRD1 BCL6 IL21R LIFR PIK3CD BIRC5 OPRM1 SOCS5 FASLG TRAF2 CASP8 SHC1-1 F13A1 ANXA1 LYN NFKBIA PTAFR TSLP IL31RA IL18BP CCR2 IFNL2;IFNL3;IFNL1 MAP2K2;MAP2K1 STX3 RAPGEF1 CRLF2 MAPK1 MAPK3 CRKL SOS1 STX1A PIK3R3 IL2RB P4HB IL36A IL36B BRWD1 CD4 IL36G MUC1 IL1F10 LCN2 IL20 IL25 IL26 IL24 PSMD12 IL11 PSMD11 IL15 PSMD14 IL19 PSMD13 IL16 PSMA7 PSMD8 MAP3K3 PSMB6 IL31 PSMB7 PSMD6 IL37 PSMB4 OSM PSMD7 IL18R1 PSMB5 PSMB2 PSMB3 RAG2 PSMD2 RAG1 PSMD3 PSMB1 PSMD1 IL36RN ADRM1 IL7R PSMC2-1 PSMA2-1 PSMA5 IL1RL2 SEM1 TEC PSMA6 CNTF PSMC5 PSMA3 PSMC6 TOLLIP PSMA4 PSMC3 PSMA1 IL10RB PSMC4 CLCF1 PSMC1 CSF3 IL5RA GSTO1 IL13RA2 IL13RA1 IL1RN IL1R2 AKT1 STXBP2 LIF YWHAZ MAPKAPK2 LBP IL11RA ITGAM IL20RA IL20RB IL22RA2 IL22RA1 HSPA8 MAPK14 MAPK11 CTF1 ZEB1 NANOG;NANOGP8 TXLNA FSCN1 IL1RAPL1 PTPN9 PTPN5 PTPN2 RBX1 GAB2 IL33 CD86 OSMR CD80 IL17C IL1RL1 IL7 CNTFR SNAP25 FN1 SYK HAVCR2 EBI3 HCK IL27 IL6ST CRLF1 IL27RA FYN CSF3R LGALS9C;LGALS9;LGALS9B ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 NDN MYD88 NFKBIB PTPN20 SAA2;SAA1 PTPN23 NKIRAS1 NKIRAS2 IKBIP IL3RA IRAK4 PELI1 PTPN14 LRRC14 USP14 PELI3 PELI2 IFNLR1 NLRC5 IL17RE TIFA IL17RB HMGB1-1 GRB2 IL22 IL18RAP SIGIRR IRAK3 IL6R TALDO1 PTGS2-2 CCR5 PTPN18 IL10RA CSF2RB CSF2RA MCL1 GSTA3;GSTA5;GSTA1;GSTA2 CEBPD CISH IRS2 AIP SOCS2 SOCS1 IL1R1 LCK SOS2 CXCL8 CHUK INPPL1 BLNK CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 PTPN13 CCL4L2;CCL4L1;CCL4 IKBKB CCL5 IKBKG CCL19 CCR1 CCL22 CCL20 ITGAX CXCL10 PPP2CB;PPP2CA PIM1 PPP2R5D PPP2R1B VAV1 RHOU MAOA CA1 ITGB1 GATA3 INPP5D FGF2 RORA PPIA IRS1 TP53 PIK3R2 PIK3CB MTAP PIK3R1 IL2RG HIF1A PTPRZ1 MYC JAK3 PIK3CA PTPN6 HMOX1 TGFB1 CCND1 ALOX5 HSPA9 CSF1R PTPN12 RELA NFKB1 IL6 ICAM1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors TFAP2A TFAP2C CITED2 PITX2 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects E2F2 CDK6 CDKN1A CDKN1B CCND1 CCND3 CCND2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CDK4 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 SKP2 TFDP1 UBE2S TFDP2 CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 RB1 ANAPC1 ANAPC2 CDKN1C E2F1 E2F3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi MANEA MAN1A2 MAN1C1 MAN1A1 MGAT1 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression CSNK2A1;CSNK2A3 WWTR1 SPOP PRKAB2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RPN2 CREBBP RPN1 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PRKAB1 H2AC20 PSMA7 NFKB2 PSMD8 H2AB2;H2AB3;H2AB1 EZH2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 ASH2L PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAGT1 JAK1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 NEK2 MIB2 BTRC NFE2L2 PSMC3 PSMA1 TEAD1 YWHAG PSMC4 PRKAG1 TEAD2 PSMC1 SKP1 TEAD3 CTNNB1 H2AJ TCF7 PRKAG3 TEAD4 TCF7L1 FOS SUZ12 H2BC5 UBA52 EPAS1 H2BC1 ERLIN1 ERLIN2 STAT1 CUL1 CDK4 ATF3 EP300 PDCD1LG2 VCP-1 RPS27A TUSC3 DERL2 H2AC4 RNF5 UBB;UBC OS9 RNF185 KMT2A KMT2C TMEM258 RBX1 STAT3 GSK3B OST4 DERL3 DERL1 DPY30 OSTC STT3A STT3B H2BC21 WDR5 IRF1 EED DDOST H2AZ2;H2AZ1 DAD1 ERLEC1 CD274 B3GNT3 HIF1A PRKAA1 CUL3 MYC JUND MYCN TNRC6C MOV10 CSNK2A2 TNRC6A-1 PDCD1 AGO4 PRKAA2 RBBP4 AGO2 RBBP5 BRD4 AGO3;AGO1 FOSB TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 RELA YAP1-1 TCF7L2 NFKB1 COPS5 H2AC14 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation MRPS17 MRPS15 MRPS16 MTFMT MRPS14 MRPS11 MTIF2 MRPS12 MTIF3 MRPL38 MRPS36 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation FGFR4 INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling TYK2 STAT3 P4HB IL23R STAT4 IL23A IL12B JAK2 IL12RB1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) MSH2 PMS2 RPA1 RPA2 MLH1 EXO1 POLD3 POLD4 RPA3 POLD2 LIG1 MSH3 POLD1 PCNA INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling SOS1 SHC1-1 ITGB3 RASGRP2 CRK RASGRP1 PTK2 FGB AKT1 FGA FGG RAPGEF3 ITGA2B PTPN1 RAPGEF4 TLN1 VWF PDPK1 BCAR1 SRC FN1 SYK RAP1A CSK RAP1B APBB1IP DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism GEMIN4 NCBP1 GEMIN5 NUP133 GEMIN6 SNRPF SNRPD2 GEMIN7 SNRPD1 GEMIN8 NUP50 POM121;POM121C SNRPB SNRPD3 NUP54 PHAX NUP42 TGS1 NUP43 SNRPE-2 RAE1 RANBP2 CLNS1A SNUPN NCBP2-1 NUP35 DDX20 NUP37 SNRPG-2 NUP107 NUP188 WDR77 SMN2;SMN1 NUP210 PRMT5 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 GEMIN2 NUP62 NDC1 SEC13 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism PIK3R3 FIG4 PIK3R6 PIK3R5 INPP5F INPP5D INPP5E INPP5J INPP5K TPTE;TPTE2 BMX RUFY1 PIK3R4 GDPD1 PIKFYVE TNFAIP8L1 GDPD3 TNFAIP8L3 MTM1 MTMR1 GDPD5 TNFAIP8L2 MTMR2 PIP4K2A MTMR3 RAB4A PTEN PIP4K2B PIP4K2C PI4K2B MTMR8 MTMR9 PIP5K1A PIK3CD PIP5K1B PIK3CG MTMR4 SYNJ2 PIK3C3 PIP5K1C PIK3R2 SYNJ1 PIK3CB PITPNB MTMR6 RAB5A PIK3R1 MTMR7 MTMR10 MTMR12 MTMR14 PIK3C2G PLEKHA1 PIK3C2A PNPLA7 PI4K2A PLEKHA2 PIK3C2B PLEKHA5 PLEKHA6 PIK3CA PLEKHA3 PLEKHA4 PLEKHA8 ARF1 PNPLA6 INPPL1 SBF1 SBF2 PTPN13 OCRL ENPP6 RAB14 PIP4P1 GDE1 PI4KA SACM1L PI4KB INPP4A INPP4B VAC14 TNFAIP8 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling ARHGEF7 SOS1 GNA13 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF IRAK1 PSENEN ABR RASGRF2 LINGO1 MAG OMG RTN4 SQSTM1 PLEKHG2 ADAM17 ARHGEF33 ARHGEF37 ARHGEF38 SOS2 PSEN1 CASP2 NCSTN PRKCI TRAF6 ARHGDIA ARHGEF40 YWHAE PRDM4 FGD1 NGFR FGD2 FGD3 FGD4 RIPK2 HDAC2 ARHGEF26 BEX3 HDAC3 HDAC1 MYD88 SMPD2 CASP3 PLEKHG5 MCF2 RAC1 ECT2 RHOA ARHGEF39 KALRN IKBKB NET1 UBA52 NFKBIA NGF TIAM1 ARHGEF10L AKAP13 RELA MCF2L ARHGEF11 AATF ARHGEF10 ARHGEF12 MAGED1 VAV3 ARHGEF15 ARHGEF17 RPS27A TRIO ARHGEF16 PSEN2 ARHGEF19 ARHGEF18 UBB;UBC NFKB1 ITSN1 VAV1 APH1A VAV2 APH1B TIAM2 PREX1 ARHGEF3 ITGB3BP ARHGEF4 MAPK8 ARHGEF1 ARHGEF2 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers ACTL6A DPF1 DPF2 DPF3 SMARCC1 SMARCC2 BICRAL BICRA ACTB-1 BRD9 SMARCE1 BCL7A SS18L1 PBRM1 BCL7C ACTL6B BCL7B SMARCA2 BRD7 SMARCA4 PHF6 BCL11A ARID1A ARID1B SMARCD1 SMARCB1 BCL11B SMARCD2 ARID2 PHF10 SS18 SMARCD3 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes TXN AKT2 SLC38A9 AKT3 PRKAB2 COX7B RHEB COX7C COX8A SCO2 SFN TP63 COX8C YWHAQ PRKAB1 YWHAH RRAGA RRAGC RRAGB PTEN MLST8 DDIT4 RRAGD COX4I1 COX4I2 COX5B GLS TP53 PRDX2 COX5A PRDX1 YWHAE PRKAA1 RRM2B COX7A2L-1 PRKAG2 COX6C MTOR TNRC6C MOV10 TNRC6A-1 PRKAA2 AGO4 YWHAG AGO2 PRKAG1 AGO3;AGO1 GLS2 TNRC6B PRKAG3 COX6A1 RPTOR COX6A2 TXNRD1 G6PD YWHAB COX7A2 GPI AKT1 COX6B2 TSC2 TSC1 COX6B1 YWHAZ TIGAR NDUFA4 CYCS-1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SESN3 SESN2 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CDK1 PPP2R1A CDK7 CCNA2-1 HJURP CCNA1 MIS18BP1 BORA MNAT1 XPO1 PPP2R3B PPP2R2A;PPP2R2D CDC25A PKMYT1 CDC25B CCNB2 CCNB1 CDK2 PPP2CB;PPP2CA FZR1 PPP2R1B OBI1 LCMT1 PPME1 TICRR FOXM1 WEE1 SGO1 CCNH PLK1 CDC25C METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals MT2A MT3 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle ARHGEF5 ITGB1 DOCK5 IQGAP2 HSPE1 DOCK4 PGRMC2 DOCK3 MAP3K11 PAK4 MCAM CAV1 PLEKHG3 MPP7 ESYT1 ARHGAP1 ARFGAP3 DSG2 EMD SHMT2 ARHGDIG ARHGAP39 DOCK2 CDC42 CDC42EP1 ARHGDIA VAMP3 ARHGDIB PIK3R1 LMAN1 ARHGAP5 ARHGEF26 ARHGAP21 STX5 LBR YKT6 OPHN1 TMPO ARHGAP35 MCF2 LEMD3 KTN1 VANGL1 DEPDC1B GARRE1 KALRN RAB7A ELMO2 DOCK1 EPHA2 PLD1 ARHGAP32 VAPB PAK2 DIAPH3 MCF2L STBD1 CYFIP1 ANKLE2 VAV3 VRK2 TRIO ARHGEF16 TFRC RHOG LAMTOR1 ITSN1 ERBIN VAV1 VAV2 PREX1 LETM1 NDUFS3 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism ALDH4A1 PRODH2 PRODH;LOC102724788 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control MRPS17 C12orf65 MRPS15 MIEF1 MRPS16 MALSU1 MRPS14 MRPS11 MRPS12 MRPL38 MRPS36 MTRES1 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 NDUFAB1 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins PDCD6IP SYT2 HSP90AB1 SYT1 VAMP2 STX1A PDZD3 FURIN VAMP1 SNAP25 SV2C SV2B SV2A HSP90AA1 CD9 EEF2 TXNRD1 CALM3;CALM1 MAP2K2;MAP2K1 MAP2K4 HBEGF MAP2K7 GUCY2C DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 HECW1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 KLHL12 DACT1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CUL3 DVL1 PSMC2-1 DVL2 PSMA2-1 DVL3 PSMA5 SEM1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) LTB4R2 NTS MCHR2 HRH1 TAC3 TAC1 OPN4 S1PR1 NMUR2 NMUR1 MLNR HTR2B HTR2A TRH LTB4R BDKRB2 BDKRB1 DRD1 CCL3L1;CCL3L3;CCL3;CCL18 DRD2 DRD3 DRD4 DRD5 POMC P2RY6 P2RY2 P2RY1 APP CCK KISS1 FFAR3;GPR42 ADORA2A ADORA3 ADORA1 C5AR2 C5AR1 C5 LHB OPN1MW3;OPN1MW2;OPN1MW;OPN1LW ADRA1D ADRA1B ADRA1A TBXA2R FSHB C3AR1 CYSLTR1 CYSLTR2 ADORA2B OPN1SW C3-1 SAA2;SAA1 MC2R SST CCR5 AGT CHRM3 AVPR2 CXCR4 CHRM2 CHRM4 ADRB1 ADRB2 HTR4 HTR6 HTR7 HRH3 HRH2 HRH4 HTR1E TAAR8 TAAR9 MCHR1 PSAP HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 RXFP4 MRGPRD CXCL9 RXFP1 CXCL8 ADRA2C RXFP2 CXCL13 RXFP3 CX3CL1 ADRA2A CCRL2 CCR9 CXCL5;CXCL6 CMKLR1 AGTR2 CCR8 FPR1 CCR7 SSTR3 CCR4 GALR3 CCR3 GALR2 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 GALR1 NPBWR1 CCL11 NPBWR2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 GPR183 CCL5 PNOC MC4R CXCR2 GPR18 CCL1 EDNRB CCL19 RHO CCL17 CCR10 EDN1 CCL16 CCR1 EDN3 GPR37 CCL25 GPR35 CCL22 CCL21 CCL20 PPBP MC3R RGR PLPPR1 CXCL10 PLPPR2 CXCL11 ACKR4 MC1R PLPPR3 ACKR2 PLPPR4 MC5R CCL28 PLPPR5 CCL27 ACKR3-2 NPFFR2 NPFFR1 NPFF P2RY12 HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR QRFP GPR55 LHCGR HCRTR2 FSHR HCRTR1 GPHA2 TSHR GPHB5 MTNR1A MTNR1B RLN3 ECE1 PRLHR INSL3 INSL5 P2RY4 APLN ECE2;EEF1AKMT4-ECE2 RRH PTGDR GPR37L1 KEL ADRA2B NLN PENK PPY PTGDR2 NPY4R2;NPY4R OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB PTGER2 PTGER3 NPW RLN2;RLN1 PRLH MAS1 XK HCAR1 PDYN HCAR2;HCAR3 NPY2R NPY FFAR1 NPY1R APLNR SUCNR1 OPN3 OXTR GRPR OPN5 EDNRA PYY PROK2 PROK1 UTS2R TRHR OPRM1 UTS2B HEBP1 AGTR1 PTGFR CENPS-CORT;CORT;CENPS LPAR1 LPAR2 LPAR3 CXCL12 GPER1 FPR2 LPAR4 NTSR1 NTSR2 GPR17 PTGIR NMB NPY5R XCR1 OPRK1 XCL1;XCL2 NMBR SSTR1 CGA LPAR5 SSTR2 LPAR6 NMS SSTR4 NMU SSTR5 GNRH1 MLN OPRL1 BRS3 CNR2 GPR132 CNR1 CCKAR GNRHR S1PR3 FFAR4 FFAR2 S1PR2 S1PR5 GPR39 S1PR4 EDN2 ANXA1 TACR2 TACR3 ACKR1 TACR1 CCKBR CX3CR1 NPSR1 GRP F2R PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 AVPR1B CHRM1 CCR2 AVPR1A GPR68 GPR65 AVP CHRM5 PMCH TSHB GHSR DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses SGSH GNS NAGLU GLB1 HYAL1 IDS GALNS GUSB IDUA ARSB HGSNAT NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 BRCA1 UBA52 PSMD12 PSMD11 DDB1 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 CUL4A PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 BARD1 CUL4B PSMC2-1 PSMA2-1 PSMA5 SEM1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants ARAF MRAS RAF1 YWHAB BRAF SHOC2 PPP1CB PPP1CC MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C5 C8G CLU C6 C7 C9 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) CSNK2A1;CSNK2A3 MGLL AGPAT2 HDAC11 BMI1 YY1 RING1 MAF HDAC5 HDAC9 RNF2 HDAC6 HDAC7 CBX8 GPAM CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 NFATC2 LPIN1 POU2F2 PHC3 PNPLA2 NFYA-1 ERBB2 EGFR YWHAE PRKACA-1 LBR PPP2R1A YWHAG SKP1 HSP90AA1 TCF7 CDC73 LEO1 AJUBA UBA52 CUL1 AURKA CCNB1 RPS27A UBB;UBC MEF2C CENPJ SPI1 TGIF1-1 CDK1 ZNF287 ZNF18 RBFOX1 RBFOX3 BCL2L11 TXN ZNF282 ZNF10 ZNF12 CLDN5 PMAIP1 DDIT3 ZNF23 BID ZNF25 BBC3 GRIN2A ZNF268 ZNF263 ABCA6 NR2F1 NR0B2 GRIN2B NR2F6 COL1A1 INS;INS-IGF2 COL1A2 ZNF496 ZNF250 UCMA ZNF45 HEY1 HEY2 ZNF41 CTLA4 ZNF248 ZNF485 ZNF483 ZNF235 SLBP ZNF473 SERPINB13 ZNF470 HTT ZNF226 ZNF222 CR1L;CR1 ATAD2 ZNF77 ZNF79 SKI ZNF70 AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 NFYB RORC RORB NFYC ZNF689 ZNF205 ZNF446 ZNF688 ZNF445 PITX2 ZNF202 ZNF200 ZNF160;ZNF347;ZNF665-1 ZFP69B CTSK FOXP3 NPAS4 ZNF432 PVALB BLK GRIA2 MAX DLX6 FOXO4 FOXO3 CTSV;CTSL ATXN3 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 SOCS4 ZKSCAN1 ZNF662 ZNF660 FBXO32 ZNF419 MMP13 ZNF658 ZNF416 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 FURIN ZKSCAN7;ZNF852 PPM1A HAND2 ITGA5 SPP1 PPM1D YAP1-1 ZNF624 ZNF621 E2F5 E2F6 ZNF747;ZNF764 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 RB1 ZNF613 SMARCB1 STUB1 CCNH EHMT2 PTPN4 EHMT1 TRIM33 UXT RRP8 LIPE LGALS3 CCN2 H2AC14 TRIM28 ZFP1 ZNF713 SAP130 ZNF711 DPF1 ZNF710 PDK4 L3MBTL2 DPF2 FOXG1 DPF3 TGFA KAT8 ZNF707 MED1 SAP30BP ZNF706 SMARCC1 ZNF704 SMARCC2 ZNF703 HIVEP3 ACSL1 WWTR1 HCFC2 YES1 MED4 IQSEC3 MED6 ITGBL1 MED7 MSTN HCFC1 HNF4G WDR82 PAXIP1 FOXO1-1 PEX11A SATB2 BAZ2A ZFP14 RXRG ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GAD1 GAD2 OGT-1 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CCNG2 PPARGC1B ZFP28 CREBBP IHH ZNF274;ZNF74 ZNF382 CCND3 SETDB1 CCND2 SS18L1 NPPA SETD1B MSX2 SETD1A SMARCA5 GEM SMARCA2 GPRIN1 SMAD2;SMAD3 CIDEC SMARCA4 ZFHX3 AUTS2 TADA2A IL2 ZZZ3 IL3 H2AC20 ZNF30 BMP2 LDB1 H2AB2;H2AB3;H2AB1 EZH1 MYBL2 EZH2 RBM14 CBX3-1 TGIF2 ELF1 PHF20 SUV39H1 ELF2 CAT PHF1 RETN ASH2L ZNF804B SGF29 MED16 ZNF175 MED17 SERPINE1 MED12 JUNB MED14 RNF111 MED13 ZSCAN25 MED10 ZNF157 CD36 ZNF398 ZNF394 JARID2 NCOA1 NKX2-5 BCDIN3D NCOA2 NR2C2AP SS18 TARBP2 ZNF383 NCOA6 ZNF140 PRKRA ELOVL5 CDC7 XPO5 NCOA3 DROSHA NR1D2 ACTL6A ZNF699-7 ZNF135 TET2 ZNF133 TET1 RARG PPHLN1 MED27 BTG1 BAZ1B ZNF568-3 SIRT1 UBE2D3-1 MED23 RSPO3 PHF20L1 TEAD1 TEAD2 NCOR2 PIWIL2 TEAD3 KAT2B PIWIL1 ZIK1 H2AJ HENMT1 TEAD4 KAT2A NR5A2 TCF12 ASZ1 PAX5 NCOR1 MAEL MED24 TDRKH-1 TAL1 MOV10L1 AEBP2 RARB MYBL1 TET3 ZNF599 MTF2 ZNF114 TDRD9 MED20 ZNF597 TDRD6 PLIN4 ZNF112 TDRD1 PLIN2 OCLN-1 TDRD12 ANGPTL4 ZIM2 FKBP6 PLIN1 ZNF584 GPS2 ZNF583 SF3B1 PCGF6 MBD3 ZNF582 CDKN2B SUZ12 H2BC5 PCGF5 MCRS1 PCGF2 MBD2 WWP1 SIRT3 H2BC1 RYBP ZNF669;ZNF670 ZNF334 GTF2H1 ZNF573 GTF2H3 ZNF570 GTF2H4 CSF2 GATAD2B ITGA2B GATAD2A ZFP30 FABP4 ZNF569 MYBBP1A ZNF567 MED31-1 ZNF566 ZFP37 MPHOSPH8 ZNF331 ZNF565 CYCS-1 ZNF563 ARID4B TTF1 IGFBP1 EP300 PF4;PF4V1-1 MTREX ZNF302;ZNF181 PHLDA1 NRBP1 MEN1 ZNF311 BOD1L2;BOD1 ZNF793 ZNF792 H2AC4 ADIPOQ ZNF791 SAP30 KRBA1 SPOCD1 ZNF549 ZNF548 TBL1XR1 ZNF317 ZNF546 ZNF354A;ZNF354B-4 ZNF304 ZNF786 ZCCHC8 KMT2D SKIL DNMT1 PLXNA4 KMT2A ZNF300 KMT2C ZNF782 KMT2B ESRRB CRCP BOD1L1 ESRRG POLR3GL ZFP69 LPL MED30 CDK6 POLR3A ZNF777 POLR3B TASOR ABL1 ZNF775 POLR3C MBIP ZNF426-1 POLR3D ZNF774 POLR3E TASP1 ZNF772 POLR3F SUDS3 ZNF324B;ZNF324 ZNF771 POLR3G MORC2 ZNF770 POLR3H DR1 ZNF529 POLR3K ZNF521 CBX5 CDK8 ZNF75D CDK7 ZNF75A STK11 CDK5 ZFP90 YEATS2 CRH ACTB-1 ZNF514 TADA3 ZNF750 MNAT1 ZNF746 PHF19 ZNF740 GSK3B KCNIP3 PIWIL4 KLF4 AKAP8L RAD51 PSIP1 ZNF606 DPY30 ZNF605 CHD4 SOX9 CHD3 ZNF839 PAGR1 ZNF555;ZNF57;ZNF556 DNMT3L TWIST2 BCL7A CITED1 SIN3B CITED2 SIN3A CITED4 H2BC21 PARP1 BCL7C GP1BA ZNF649 ZNF3 BCL7B ZNF350;ZNF432 UBTF ZNF557;ZNF558 DNMT3B NPY WDR5 CAMK4 LMO1 RBM7 ZNF197;ZNF660-ZNF197 KDM6A TBP LMO2 EED ATP1B4 DNMT3A LIFR KCTD6 H2AZ2;H2AZ1 ZNF124-4 ARID1A COX4I1 NOP2 ARID1B COX4I2 ZNF264;ZNF805-1 SMAD1 POLR1A SMAD4 POLR1B SMURF2 POLR1C SMURF1 POLR1D SMAD6 POLR1E ESR2 POLR1F SMAD7 POLR1G NR4A1 POLR1H NR4A3 C19orf84 THRA ARNT SMARCD1 NR2E1 CEBPA YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 OPRM1 SMARCD2 CAMK2B ACSS3 CAMK2D HDAC2 CAMK2A SMARCD3 NR2C2 HDAC3 THBS1 UHRF1 HSPD1 HDAC1 HES1 CXXC1 CAMK2G DDX21 ZNF189 TAF1D ZNF286A MTA1 ZNF184 TAF1B ZNF180 RBBP4 OPRK1 TAF1C RBBP5 SAP30L TDG TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L SMARCE1 ATF7IP DEK EPOP H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 ERCC3 KANSL2 SCD KANSL3 ERCC2 THRSP ERCC6 NDUFA4 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RXRB ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 G6PD YWHAB XPO1 AKT1 YWHAZ MAPK14 MAPK11 GLI3 GLI2 RBX1 ANG ITCH PIP4K2A PIP4K2B PIP4K2C MED8 CCNK CCNT1 GTF2B SUPT16H GTF2F1 GTF2F2 NEDD4L GTF2E1 GTF2E2 PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B RRM2-1 ELL ELOC-1 TAF7L ELOA NELFB ELOB NELFCD NELFA NELFE NCBP1 GTF2A1 GTF2A2 CTDP1 RNMT TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 ESRRA TAF7 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 GLS2 TXNRD1 FKBP5 PPP2CB;PPP2CA AXIN1 PPP2R5C PPP2R1B MTERF1-1 RET TFB2M GATA3 TFAM-1 POLRMT HNF4A JAG1 PRDM1 MYC COX7A2L-1 ARNTL TNRC6C MOV10 ARNT2 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 COX7A2 TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EAF1 EAF2 RRN3 AKT2 AKT3 SNRPD3 SUPT6H AFF4 POMC SNRPE-2 SFN MLLT1 MLLT3 NLRC4 IWS1 CASP1 TXNIP SKP2 PRMT1 MET TCF7L1 DLX5 SOX2 MYB TSC2 TSC1 STAT1 TJP1 ZFPM1 GATA4 GATA2 GATA1 NFE2 SNRPF SNRPB IRAK1 CAV1 YWHAQ YWHAH PDPK1 SNRPG-2 DICER1 PTPN11 CALM3;CALM1 PABPN1-1 SOD2 IFNG CCNE2 CCNE1 PLK2 MDC1 ATF2 TP53RK NOC2L SGK1-1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 MAML2 RHNO1 MAML1 E2F4-1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 TFDP1 NUAK1 PCBP4 PRDX1 TFDP2 TP53BP2 ATRIP MAML3 PRELID3A NOTCH2 NOTCH3 BANP BARD1 NOTCH4 PLK3 PRELID1 E2F1 CRADD GADD45A TPX2 RAD17 JUN ATM SNW1 CDK12 MAMLD1 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM BRCA1 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D BRPF3-1 PCNA WRN PLAGL1 PERP PMS2 SOCS3 RICTOR BRD7 PTPN1 TIGAR RPA1 RPA2 BRF2 CDK4 MLH1 BDP1 HIPK1 CDK2 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 FANCI BRPF1 CNOT10 FANCC CNOT4 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CNOT1 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 PHF6 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA RBL2 RBL1 BIRC5 TMEM219 PRKAA1 TRPC3 RNF34 AURKB TP53INP1 RBBP8 RFFL E2F7 E2F8 ARID3A PML MTOR RAD50 BAX HDAC10 FASLG EPC1 PRDM7;PRDM9 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SSB NFIX PRKCQ NFIA NFIB IPO8 NFIC PRMT6 PBRM1 ACTL6B BDNF CDK5R1 GCK YEATS4 MAPK1 MAPK3 ARID2 CCNA2-1 CCNA1 KDM5B PRKAB2 HDAC8 SCO2 REST DDX4 PRKAG2 MED15 TSNAX MED26 TSN MED25 KIT PPARD GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 BRF1 GTF3A GTF3C6-1 PRKCB RAMAC LSM10 LSM11 NABP1-1 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 PHAX ZNF143 G6PC1 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 SP1 RPRD1B RPRD1A SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 PTEN CPSF2-1 NUDT21 RRM2B USP9X PRKAA2 BRIP1 WDR61 APOE PCK1 WDR33 PAPOLA FIP1L1 COX7B COX7C COX8A SREBF1 COX8C CSTF3 CSTF2 SRC SRF COX5B COX5A COX6C CPSF4 CPSF1 CPSF3 COX6A1 COX6A2 COX6B2 COX6B1 SRRT CTR9 RTF1 SYMPK PAF1 CAVIN1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR4A2 NR5A1 AR RXRA SUMO1 SUMO2 RARA CARM1 PGR PPARG PPARA CSTF2T TP53 GLS NAMPT GAMT CLP1 DGAT2 CSNK2A2 CGA NR1D1 CSNK2B CPSF7 PLD6 GPI PCF11 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria BCL2L11 MAPK8 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling SOS1 IRS1 HRAS IRS2 NRAS AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation ACSM1 GLYATL3 ACSM5 ACSM4 ACSM2A;ACSM2B GLYAT BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency DLD BCKDHA DBT BCKDHB BCKDK REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBB;UBC TBK1 TANK TLR3 IKBKE TICAM1 OPTN-1 TRAF3 RPS27A UBA52 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms JUN WNT5A CYBA NOXO1 MAPK8 DVL1 RAC1 NOX1 NOXA1 FZD7 DVL2 DVL3 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants FLT3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ZP1 ZP2 ZP4 ADAM21 ADAM20 ADAM30 ADAM2 B4GALT1 SPAM1 ZP3;POMZP3 OVGP1 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR MSH2 PMS2 RPA1 RPA2 MLH1 EXO1 POLD3 POLD4 RPA3 POLD2 LIG1 MSH6 MSH3 POLD1 PCNA BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) ALOX5AP ALOX15 ALOX12 HPGD LTA4H PTGS2-2 GSTM4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 LTC4S ALOX5 CYP1A1 CYP1A2 PTGR1-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) S100A8 FGG TLR2 MYD88 LY96 BTK TLR6 S100A1 CD14 HMGB1-1 TIRAP TLR4 CD36 TLR1 FGB FGA S100A9 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) ACTL6A DPF1 DPF2 DPF3 SMARCC1 SMARCC2 ACTB-1 SMARCE1 BCL7A SS18L1 BCL7C ACTL6B BCL7B SMARCA2 SMARCA4 BCL11A ARID1A ARID1B SMARCD1 SMARCB1 BCL11B SMARCD2 PHF10 SS18 SMARCD3 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PSPN FRS2 GAB1 GFRA2 SOS1 GFRA4 PIK3CA PTPN11 ARTN MAPK7 GRB10 PIK3R3 RET GAB2 GRB7 DOK2 DOK1 SHC1-1 GFRA3 IRS2 PRKACB-1 DOK4 DOK5 GFRA1 DOK6 PRKCA GDNF SHC3 RAP1GAP PIK3CD SHANK3 PIK3R2 PIK3CB PLCG1 PDLIM7 PIK3R1 NRTN PRKACA-1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis FAR1 AWAT2 FAR2 AWAT1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins C1GALT1C1 GCNT3 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 MUC12 A4GNT MUC15 B4GALT6 MUC3A MUC5AC B4GALT5 ST6GAL1 MUC1 MUC2 MUC7 MUC4 MUC6 GALNT3 ST3GAL4 MUC17 ST6GALNAC2 C1GALT1 MUC5B ST3GAL1 MUC20 ST3GAL2 MUC21 ST3GAL3 B3GNT7 B3GNT5 B3GNT4 B3GNT3 ST6GALNAC3 B3GNT2 ST6GALNAC4 MUC13 GALNT2 GALNT1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT10 GALNT9;GALNT17 GALNTL5 GALNTL6 B3GNTL1 GALNT9 GALNT8 B3GNT9 B3GNT8 B3GNT6 CHST4 GCNT1 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1 KCNA5 KCNH2 KCNE1;KCNE1B AKAP9-1 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses IFNB1-4 TYK2 STAT2 RBX1 IFNAR1 IRF3 EP300 DDX58 RPS27A UBB;UBC EIF2AK2 ELOC-1 IFIH1 TRIM25 MAVS JAK1 ELOB CREBBP CUL5 UBA52 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors YEATS4 TFAP2A WWOX CREBBP TFAP2C CITED1 TFAP2D CITED2 EP300 CITED4 TFAP2E;TFAP2B EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria AUH DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 NOTCH1 NOTCH2 NOTCH3 LFNG NOTCH4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization SOS1 GRAP2 PLCG2 BTK LCP2 CALM3;CALM1 LYN TXK NFATC3 ITPR1 ITPR2 ITK ITPR3 PPP3R1 VAV3 NFATC2 NFATC1 AHCYL1 SYK PPP3CA PPP3CB PLCG1 VAV1 VAV2 TEC FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands FPR2 APP SAA2;SAA1 ANXA1 HEBP1 FPR1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA AURKA PHLDA1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation NDUFAB1 HADH HADHA ACAA2 MCAT PCCA PCCB ACOT11 ACOT12 ACOT13 ECI1 ACBD7 ACBD6 ACSM3 THEM5 THEM4 MCEE ACSF2 MMAA ACADL ACADVL MMUT ACADM ECHS1 ACADS ACOT9 HADHB-1 ACOT2;ACOT1 MECR ACOT7 PCTP ACAD11 ACAD10 DECR1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NFKBIB BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK REL FBXW11 NFKBIE IKBKB CARD11 BCL10 IKBKG MALT1 UBA52 NFKBIA CUL1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 PRKCB GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA PIWIL4 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B ANG POLR2C POLR2D H2BC21 POLR2G POLR2I H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 RAN DDX4 BCDIN3D TARBP2 PRKRA XPO5 DROSHA DICER1 TNRC6C TNRC6A-1 AGO4 AGO2 PIWIL2 AGO3;AGO1 PIWIL1 H2AJ TNRC6B HENMT1 HSP90AA1 ASZ1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MAEL POLR2E TSNAX TDRKH-1 TSN POLR2F MOV10L1 MYBL1 POLR2H TDRD9 TDRD6 TDRD1 POLR2L TDRD12 IPO8 FKBP6 PLD6 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 DGCR8 H2BC1 POLR2J;POLR2J2;POLR2J3 H2AC4 H2AC14 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m DOLK ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI MBOAT7 PLA2G4A PLAAT3 PLA2G1B PLBD1 PLA2R1 PLA2G5 PLA2G2A-1 PLA2G10;LOC100652777 PLA2G2F PLA2G12A PLA2G4F PLA2G2D PLA2G2E PLA2G4D PLA2G4E IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs RAF1 IFNGR1 MAPK1 IFNGR2 JAK1 MAPK3 IFNG JAK2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction TMOD2 TTN-1 DMD TMOD3 NEB MYH3 VIM MYH8 MYH6 TNNI1 TNNI2 TNNI3 ACTN2 DES ACTN3 MYL4 MYL1 MYL2 MYL3 TPM4 TPM3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TMOD4 TPM2 TPM1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 MSH2 MSH6 MSH3 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV GBE1 GYG2 GYS2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT PLAUR GPAA1 PIGK CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC5A10 SLC45A3 SLC2A10 MFSD4B-2 SLC2A4 SLC2A6 SLC2A7 SLC2A1 SLC2A2 SLC50A1 FGF21 SLC2A9 SLC5A9 SLC5A2 SLC5A4 SLC2A11 SLC2A8 SLC5A1-1 SLC2A12 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling LPL MTTP P4HB APOB APOA2 APOA1 APOA4 PCSK5 LMF2 LMF1 MBTPS1 APOA5 LIPC CREB3L3 ANGPTL8 PCSK6 ANGPTL3 FGF21 MBTPS2 ANGPTL4 APOC3 APOC2 FURIN APOF LIPG LCAT ALB CETP ABCG1 APOE GPIHBP1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase BUB1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 LBR PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 CKAP5 TUBA4A XPO1 UBA52 PAFAH1B1 TNPO1 DYNC1I2 CCNB2 CCNB1 ANKLE2 RPS27A CLASP1 UBB;UBC DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CDK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 IST1 SPAST CC2D1B NUF2 KIF2A EMD NUDC KIF2C KIF2B INCENP CENPA CENPE CENPC CENPT NUP107 CENPU NUP188 RCC1 BANF1 CENPF CENPH CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A LMNB1 CENPL NUP205 CENPM CENPO PPP2R2A;PPP2R2D CENPP NUP160 NUP85 CENPQ TUBA1C TUBB1 NUP155 CHMP2B CHMP2A TUBB2B;TUBB2A CLIP1 MAD1L1 NUP62 NDC1 SEC13 TUBB3;TUBB6 TUBAL3 NUP133 NDC80 RANGAP1 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 TUBA3E;TUBA3C-1 VPS4A SPDL1 NUP43 RANBP2 TUBA8 NSL1 NUP35 RAN NUP37 KNL1 ZW10 CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 RCC2 ZWINT AHCTF1 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E VRK1 LEMD2 DYNC1I1 KPNB1 UBE2I B9D2 SPC24 SPC25 ERCC6L SUMO1 ZWILCH SIRT2 PMF1;PMF1-BGLAP KNTC1 BIRC5 SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPS14 NCBP1 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 ETF1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 UPF1 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 NCBP2-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 EIF4G1 RPSA RPL17 RPL19 RPS15 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors AGT NTS MCHR2 TAC3 TAC1 NMUR2 NMUR1 AVPR2 MLNR TRH CXCR4 BDKRB2 BDKRB1 CCL3L1;CCL3L3;CCL3;CCL18 POMC APP CCK KISS1 MCHR1 PSAP RXFP4 MRGPRD CXCL9 RXFP1 CXCL8 CXCL13 RXFP2 RXFP3 CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 AGTR2 CCR8 FPR1 CCR7 SSTR3 CCR4 GALR3 CCR3 GALR2 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 GALR1 NPBWR1 CCL11 NPBWR2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 PNOC MC4R CXCR2 CCL1 EDNRB CCL19 CCL17 CCR10 EDN1 CCL16 CCR1 EDN3 GPR37 CCL25 CCL22 CCL21 C5AR2 CCL20 PPBP MC3R C5AR1 CXCL10 CXCL11 ACKR4 MC1R ACKR2 MC5R CCL28 CCL27 C5 ACKR3-2 NPFFR2 NPFFR1 NPFF PF4;PF4V1-1 HCRT QRFPR QRFP HCRTR2 HCRTR1 RLN3 ECE1 PRLHR INSL3 INSL5 APLN ECE2;EEF1AKMT4-ECE2 GPR37L1 KEL NLN PENK PPY NPY4R2;NPY4R GAL OPRD1 NPB NPW RLN2;RLN1 PRLH MAS1 XK PDYN NPY2R NPY NPY1R APLNR C3AR1 OXTR GRPR EDNRA PYY PROK2 PROK1 UTS2R TRHR OPRM1 UTS2B HEBP1 AGTR1 CENPS-CORT;CORT;CENPS CXCL12 GPER1 FPR2 NTSR1 C3-1 NTSR2 SAA2;SAA1 NMB NPY5R XCR1 OPRK1 XCL1;XCL2 NMBR SSTR1 SSTR2 NMS SSTR4 NMU SSTR5 MLN OPRL1 MC2R BRS3 CCKAR EDN2 ANXA1 TACR2 TACR3 ACKR1 TACR1 CCKBR CX3CR1 NPSR1 F2R GRP F2 NPS PROKR1 PROKR2 KISS1R OXT-1 KNG1 F2RL1 F2RL2 CCR6 F2RL3 AVPR1B CCR2 AVPR1A SST AVP PMCH CCR5 GHSR STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses XRCC6 TBK1 STAT6 PRKDC XRCC5 CGAS STING1 TRIM21 IRF3 IFI16 NLRP4 MRE11 TREX1 DDX41 DTX4 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins NUP133 L3MBTL2 NUP50 POM121;POM121C CBX5 NUP54 BMI1 SATB2 HDAC4 RING1 NUP42 UBE2I CHD3 SATB1 NUP43 PIAS1 RNF2 RAE1 RANBP2 CBX8 SUMO1 SUMO3 SUMO2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 NUP37 HDAC2 HDAC1 ZBED1 NUP107 NUP188 NUP210 NUP93 NUP205 AAAS SUZ12 PCGF2 NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome HSP90AB1 TXN APP RELA MEFV NFKB2 HMOX1 PANX1 PYCARD P2RX7 PSTPIP1 CASP1 TXNIP SUGT1 NFKB1 NLRP3 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A GALNS TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 HDAC1 MTA1 RBBP4 EBF2 RBBP7 PRDM16 MTA2 MTA3 CIDEA ELOVL3 BMP7 CHD4 CHD3 PPARGC1A PPARGC1B MBD3 GATAD2B RXRA GATAD2A UCP1 PPARG PPARA HNRNPU SMAD1 SMAD4 ZNF423 NCOA1 HDAC2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus BRCA2 SEM1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex NCBP1 CDK7 POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 NELFB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs ALOX12 ALOX15 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression CD28 VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction LPL METAP1 GNAT1 METAP2 AKR1B15;AKR1B10 APOB RBP3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW LRAT AWAT2 SDC4 RBP4 SDC2 DHRS3 SDC3 RBP2 GNB1 RBP1 SAG DHRS9 HSPG2 RDH10 RDH12 RETSAT RDH11 RPE65 LOC118142757;GUCA1A SDC1 RDH8 FNTA HSD17B1 PDE6B PDE6A PLB1 CLPS OPN1SW RLBP1 GUCA1C GPIHBP1 MYO7A FNTB;CHURC1-FNTB APOA2 APOA1 APOA4 PPEF1 PNLIP GUCY2D LRP1 HSD17B6 CALM3;CALM1 TTR BCO2 PRKCQ CNGB1 LRP2 BCO1 GPC1 STRA6 LRP8 GPC3 APOC3 RHO GPC2 GPC5 CNGA1 GPC4 ABCA4 SDR9C7 SLC24A1 APOC2 GNGT1 GPC6 PRKCA CAMKMT RGS9BP LRP10 AGRN LRP12 NMT1 NMT2 RDH5 APOM CYP4V2 GRK1 GRK7 LDLR APOE RCVRN DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle ADD3 SRGAP2 BAIAP2L2 TOR1AIP1 BAIAP2L1 FARP1 ARHGAP12 TMPO ACTN1 SLC4A7 VANGL1 ACTB-1 DEPDC1B SNAP23 RAB7A CAPZB LMNB1 MCAM CAV1 MYO9B DIAPH1 ARHGAP32 DIAPH2 DIAPH3 ESYT1 ARHGAP1 SOWAHC AKAP12 MTMR1 ARHGAP39 SYDE1 BASP1 RHOF VAMP3 PIK3R2 SENP1 STEAP3 PIK3R1 ARHGAP5 ARHGAP21 FAM169A LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation HDAC1 MTA1 RBBP4 EBF2 RBBP7 PRDM16 MTA2 MTA3 CIDEA ELOVL3 BMP7 CHD4 CHD3 PPARGC1A PPARGC1B MBD3 GATAD2B RXRA GATAD2A UCP1 PPARG PPARA HNRNPU SMAD1 SMAD4 ZNF423 NCOA1 HDAC2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases FBXL18 CCNA2-1 TUBG2 CCNA1 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 HMMR CDC25B PSMA7 PSMD8 MYBL2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE CEP57 CETN2 ADRM1 CEP164 CCP110 AKAP9-1 PSMC2-1 PPP1CB E2F1 PSMA2-1 MAPRE1-1 PSMA5 E2F3 SEM1 TPX2 PRKACA-1 ACTR1A PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 CNTRL PSMC6 CEP250 PSMA4 NEK2 BTRC CDKN1A PSMC3 CEP290 PSMA1 YWHAG PSMC4 RAB8A PSMC1 SKP1 CDK5RAP2 HSP90AA1 OPTN-1 HJURP CEP135 PPP1R12A BORA MIS18BP1 FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 XPO1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 CDK2 HAUS8 PRKAR2B PPP2CB;PPP2CA HAUS7 CEP70 CEP72 EP300 CEP192 RPS27A PHLDA1 PCNT PPP2R1B OBI1 CEP76 LCMT1 CLASP1 PPME1 UBB;UBC CEP78 TICRR PLK4 OFD1-1 FOXM1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ CDC25C ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E FBXL7 CEP41 CEP43 RBX1 CDK7 GTSE1 FKBPL MNAT1 PPP2R3B HSP90AB1 PKMYT1 TP53 WEE1 SGO1 RBBP4 CENPF LIN54 LIN37 LIN9 LIN52 PPP2R2A;PPP2R2D FZR1 CCNH PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway PLA2G4A MAPK1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade METAP1 GNAT1 METAP2 FNTB;CHURC1-FNTB GUCY2D PPEF1 CALM3;CALM1 PRKCQ CNGB1 RHO GNB1 CNGA1 SAG GNGT1 PRKCA CAMKMT RGS9BP NMT1 LOC118142757;GUCA1A NMT2 GRK1 FNTA PDE6B GRK7 PDE6A RCVRN GUCA1C BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions ITGB1 SLC16A8 SLC16A3 ITGA6 ATP1B2 ATP1B1 SLC7A6 SPN SLC7A7 MMP1 SLC7A8 SLC7A9 SLC7A5 MAG SLC3A2 BSG CAV1 ATP1B3-1 PPIL2 ITGA3 SLC16A1 L1CAM PPIA SLC7A11 SLC7A10 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX15 ALAS2 ALAS1 CPOX ALAD ALB COX10 UROS PPOX ABCG2 UROD HMBS FECH HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells RAMP2 GNG10 GNAS-1 GNG2 ADCY9 GNG5 NOS3 GNG4 PRKAR1B GNA11 PRKAR1A GNG8 ADCY4 ADCY3 CAPNS1 ADCY2 ADCY1 CAPNS2 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 CAPN2 PRKACB-1 GNAQ GNB2 PRKAR2A GNB1 ADM GNB4 VCL GNB3 P2RY2 PRR5 GNB5 TLN1 CDH5 PDPK1 PANX1 CALCRL MLST8 PIK3CD MAPKAP1 PIK3R2 PIK3CB PECAM1 FYN PRKACA-1 PIK3CA MTOR TRPV4 KDR CTNNB1 CALM3;CALM1 MMP14 PKN2 AKT1 GNGT1 RICTOR PRKAR2B FLT4 PIEZO1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation AMT DDO DLD GNMT GRHPR GOT2-1 DAO ALDH4A1 PXMP2 MRPS36 DLST GCSH-3 OGDH AGXT2 PRODH2 HOGA1 GLDC AGXT HAO1 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis ARPC4 IGF2R ARPC5 NECAP1 TGFA COPS4 APOB ARPC2 ARPC3 RAB5B COPS2 AVPR2 CD4 ACTR2 CHRM2 WNT5A ADRB2 WASL GRK2 HIP1 FZD4 M6PR SYNJ2 CLTB SCARB2 PIP5K1C ARRB2 AGFG1 SYNJ1 EGF STON1-GTF2A1L ARF6 KIAA0319 RAB5A TOR1A EGFR TOR1B SYT9 SYT8 DAB2 IL7R CLTCL1 SNAP91 STON2 EPS15L1 PIK3C2A SLC2A8 EPN1 SLC18A3 SGIP1 EPN2 VAMP4 FCHO1 FCHO2 UBQLN1 REPS2 AREG REPS1 UBQLN2 EPS15 NECAP2 SYT11 CFTR EREG BTC STAM HBEGF PICALM CLTC CLTA UBA52 AP2A1 AP2B1 CBL AP2A2 SYT1 DNM1 DNM2 VAMP2 DNM3 AP2S1 SH3GL2 ITSN2 RPS27A TFRC UBB;UBC ITSN1 HSPA8 FNBP1L CTTN FNBP1 TF BIN1 SNX18-1 AMPH PACSIN2 PACSIN3 PACSIN1 SH3GL3 SH3GL1 TRIP10 ARPC1A CD3D GRK3 CD3G VAMP3 GPS1 AGTR1 STAM2 HGS OCRL LRP2 TACR1 EPGN ARRB1 SYT2 ACTR3-1 LDLRAP1 COPS7B COPS7A VAMP7 VAMP8 SH3KBP1 GAK DNAJC6 RAB5C TGOLN2 COPS3 COPS6 COPS5 ARFGAP1 SNX9 AVP LDLR GAPVD1 COPS8 DVL2 HIP1R TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 RBFOX1 FOXG1 GRIN2A CRH IRAK1 GRIN2B GAD1 GAD2 SIN3A SGK1-1 GPRIN1 HTT CAMK4 DLL1 PTEN PPARG GAMT TRPC3 OPRM1 CAMK2B AURKB CAMK2D HDAC2 CAMK2A PRKACA-1 HDAC3 HDAC1 LBR MET CAMK2G TNRC6C MOV10 TNRC6A-1 PVALB OPRK1 AGO4 AGO2 NCOR2 GRIA2 AGO3;AGO1 TNRC6B NCOR1 CALM3;CALM1 GPS2 SOX2 FKBP5 DGCR8 BDNF PTPN1 HIPK2 SST TBL1XR1 MEF2C PTPN4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation MAPK14 PRKAB1 PRKAB2 PRKAA2 MAPK11 PRKAG1 PPARGC1A MAPK12 PRKAG3 PRKAG2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System ABCC8 STX1A ABCC9 GJC1 KCNK10 PTPRF GJA10 KCNJ14 KCNK13 PRKAB2 KCNK16 GRM1 KCNK18-1 GJD2 GRM5 KCNK17 KCNK2 CACNA2D2 KCNK4 BCHE SLC6A4 PANX1 GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 KCNK6 KCNK7 KCNK1 KCNN1 SYT9 KCNN3 KCNN4 KCNC2 HCN4 HCN3 SLC18A3 HCN2 PRKAG2 HCN1 PRKACA-1 FLOT2 SHARPIN SLC5A7 NTRK3 UNC13B RAB3A SYT1 PRKCA SYN3 CPLX1 SYN2 KCND1 SYN1 KCND2 RIMS1 PPFIA1 PRKAR2B KCND3 PPFIA4 SLC18A2 PPFIA3 PPFIA2 PANX2 KCNB1 RPS6KA3 RPS6KA2 KPNA2 RPS6KA1 KCNG2 HSPA8 PRKCB IL1RAPL1 STXBP1 KCNMB1 KCNMB2 ARL6IP5 KCNMA1 KCNMB3 NAAA KCNMB4 ADCY9 PRKAR1B PRKAR1A GRIN2A ADCY4 LRFN3 ADCY3 LRFN2 MYO6 GRIN2B LRFN4 ADCY2 LRFN1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PTPRD PPFIBP2 PRKAR2A SLITRK2 SLITRK1 SLITRK4 IL1RAPL2 SLITRK6 LRRC4B SNAP25 PDPK1 CAMK1 CAMKK1 CAMKK2 PPFIBP1 GNAT3 HRAS GNAI3 NRAS COMT KCNAB2 PRKAA2 GRIA2 CALM3;CALM1 TSPOAP1 RPS6KA6 CHRNB2 ACTN2 CHRNA2-1 CASK CHRNA1 CHRNB4 CHRNA9 CHRNA3 LIN7A CHRNB3 LIN7C GRIN2C CHRNA5 GRIN2D CHRNA4 GRIN3B CHRNA6 GRIN3A GNAL SLC32A1 DLG2 SLC6A13 GNGT1 DLG3 ABAT SYT2 NBEA GABRB3 SLC6A1 GABRB2 ALDH5A1 GABRB1 KCNQ1 GRIK5 RASGRF1 GRIK3 GRIK4 GRIK1 GRIK2 PLCB3 NRGN GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 PLCB1 PLCB2 NPTN NEFL SLC1A1 HTR3A HTR3B LRRC7 SLC1A2 SYT10 SLC1A3 LIN7B CHRNA7;CHRFAM7A KCNA5 PPM1E PPM1F SIPA1L1 NCALD GLRA1 LRRTM3 CHRND KCNH2 CACNB1 LRRTM4 GLRA2 CACNB4 LRRTM1 CACNA2D1 GLRA3 SLC1A6 LRRTM2 CACNA2D3 DLGAP1 CHRNG HOMER3 CHRNE CACNA1B SLC1A7 DLGAP3 KCNJ2 DLGAP4 KCNJ12;KCNJ18 SHANK2 KCNJ3 GABRQ SLC38A2 SHANK1 NLGN3 KCNJ4 GABRA2 NLGN1 GNG10 GABBR2 NLGN2 KCNQ2 EPB41 GABRA1 KCNQ3 SLC38A1 NRXN3 GNG2 KCNJ5 GABBR1 NRXN2 GNG5 BEGAIN GNG4 KCNJ6 EPB41L5 KCNJ10 EPB41L2 GABRA6 GNG8 GABRA5 PDLIM5 NLGN4X;NLGN4Y KCNJ9 HOMER1 GABRA4 HOMER2 GABRA3 SYT7 KCNJ15 RASGRF2 KCNJ16 SYT12 GRIN1 APBA3 APBA2 GLRB APBA1 GAD1 GAD2 GNG13 CACNB2 CACNB3 GNB2 GNB1 PRKCG GNB4 GNB3 GNB5 PRKAB1 SRC SHANK3 SLITRK3 GNAI1 SLITRK5 GNAI2 PTPRS KIF17 KCNS3 PRKAG1 SLC22A2 GLS2 SLC22A1 RAC1 PRKAG3 NRG1 SLC17A7 KCNJ11 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 VAMP2 NRXN1;NRXN3;NRXN2 GLUL GIT1 CACNA1A SLC6A12 SLC6A11 LRTOMT CACNA1E DBNL MAOA KCNK9 KCNK3 MDM2-2 KCNJ1 KCNJ8 RTN3 CAMK4 KCNG1 KCNG3 KCNG4 GLS KCNC1 KCNA1 KCNC3 KCNA2 KCNC4 KCNA3 KCNA4 KCNA6 PRKAA1 KCNA7 KCNV1 CAMK2B KCNV2 CAMK2D KCNH1 CAMK2A KCNF1 AKAP5 KCNH3 SLC6A3 KCNH4 KCNH5 KCNH6 CAMK2G KCNH7 KCNH8 KCNB2 KCNAB1 KCNAB3 KCNS1 KCNS2 DNAJC5 KCNA10 KCNQ5 KCNQ4 CHAT KCNN2 DLG4 FLOT1 ACHE ALDH2 PRKX MAPK1 MAPK3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse PTPN22 LCK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 ZAP70 CD4 CD3E CD3D HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DRA CD3G DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 MBD4 SMUG1 NTHL1 APEX1 MPG TDG OGG1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine NEIL3 H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPG H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 OGG1 H2BC1 H2AC14 H2BC21 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR TRAF6 PSEN2 ADAM17 NFKB1 APH1A APH1B RELA NGFR PSEN1 PSENEN NCSTN REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination USP8 LGR5 LGR4 ZNRF3 RSPO3 FZD5 FZD4 FZD6 RPS27A FZD8 RNF43 UBB;UBC WNT3A RSPO2 RSPO1 RSPO4 LRP5 UBA52 LRP6 LGR6 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC12A3 SLC12A1 SLC34A2 SLC34A1 SLC26A7 SLC12A6 SLC26A9 SLC26A6 SLC4A7 SLC26A4 SLC26A3 SLC26A11 SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC5A8 SLC13A1 SLC26A2 SLC13A4 SLC26A1 SLC4A8 AHCYL2 SLC20A1 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLC4A1 SLC4A4 SLC20A2 SLC5A5 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors ABCG5 NR1H3 APOC1 PIK3R3 APOC4 AKT2 AKT3 ADH1C;ADH1B;ADH1A PTGES3-1 YY1 KDM3A KDM4A KDM4B APOD GPAM POU2F1 RDH11 EGF EGFR RXRB PRMT1 AREG HSP90AA1 PDHB TLE3 XPO1 MYB AKT1 APOC2 KDM1A PPARD PDK3 ELK1 PDK2 PDK1 PDHX KPNA2 BCL2 STRN DDX5 PRKCZ CAV1 CRABP2 CRABP1 DHRS3 DHRS4 ALDH1A3 SP1 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH14 ZDHHC21 HSP90AB1 RDH13 ALDH8A1 PDPK1 GNAT3 HRAS GNAI3 PPID NRAS CCNT1 CTSD FOXO3 MMP7 GTF2F1 MMP2 CALM3;CALM1 GTF2F2 MMP3 MMP9 IGF1R UHMK1 EPGN GNGT1 CDK9 POLR2J;POLR2J2;POLR2J3 SPHK1 APOE PCK1 ALDH1A1 H2AC14 PDK4 TGFA GNG10 CYP26A1 MED1 GNG2 GNG5 NOS3 GNG4 GNG8 GTF2A1 GTF2A2 RXRG POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 POLR2B POLR2C CREBBP GNB2 ATF2 POLR2D GNB1 GNB4 POLR2G KAT5 GNB3 POLR2I GNB5 H2AC20 H2AB2;H2AB3;H2AB1 SRC SRF GNAI1 GNAI2 NCOA1 NCOA2 NCOA3 ABCA1 JUN RARG CDKN1B NCOR2 KAT2B H2AJ NR5A2 NCOR1 RARB EREG BTC PLIN1 GPS2 ZDHHC7 FOS HBEGF FKBP5 CAV2 PTK2 H2BC5 PPP5C H2BC1 DLD AXIN1 EP300 H2AC4 CETP TBL1XR1 ARL4C FASN EEPD1 ABCG1 PDHA1 FABP5 FABP6 CYP26B1 GATA3 NR1H2 CITED1 ESR1 H2BC21 RXRA DLAT TBP RARA MYLIP PGR CARM1 KCTD6 H2AZ2;H2AZ1 PIK3R2 ESR2 PIK3R1 FOXA1 SMC3 FKBP4 MYC RAD21 JUND GREB1 STAG1 HDAC3 CXCL12 STAG2 HDAC1 SMC1A PIK3CA TFF1 KANK1 TNRC6C ADH4 MOV10 CXXC5 TFF3-1 TNRC6A-1 AGO4 NRIP1 AGO2 USF2 USF1 AGO3;AGO1 ZNF217 FOSB TNRC6B EBAG9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 POLR2E CBFB POLR2F ANGPTL3 POLR2H RUNX1 S1PR3 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 SCD KDM1B RDH5 MAPK1 MAPK3 ABCG8 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events CASR PLA2G4A MCHR2 TAS2R3-1 NMUR2 NMUR1 TAS2R16 BDKRB2 BDKRB1 RGS18 DRD3 RGS17 DRD4 RGS19 RGS13 POMC TAS2R40 RGS16 TAS2R41 RGS21 APP PDE1C GRK2 TAS2R39 ADORA3 ADORA1 PRKACA-1 PPP2R1A PPP1CA TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PRKCD PRKCA C5AR1 C5 PRKAR2B PRH1-TAS2R14;TAS2R14-3 KPNA2 PDE1B PDE1A TAS2R7 GNAS-1 TAS2R8 ADCY9 PRKAR1B PRKAR1A ADCY4 GRM4 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW ADCY3 ADCY2 TAS2R1 ADCY1 TAS2R4 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A CAMKK1 CAMKK2 C3AR1 TAS1R2 TAS1R1 TAS1R3 GNAT3 GNAZ GNAI3 OPN1SW C3-1 SAA2;SAA1 CALM3;CALM1 GNAL GNGT1 NBEA RGS9 RGS6 RGS7 PLCB3 PLCB4 PLCB1 PLCB2 SST CCR5 GNA14 GNG10 GABBR2 AGT GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 CXCR4 GNG13 GNAQ GNB2 GNB1 GNAT2 PRKCG GNB4 CHRM2 GNB3 CHRM4 ITPR1 ITPR2 GNB5 ITPR3 RGS11 PPP3R1 HRH4 HTR1E SRC MCHR1 PSAP HTR1F HTR1D HTR1B PPP3CA PPP3CB GNAI1 HTR5A GNAI2 RXFP4 CXCL9 CXCL8 ADRA2C CXCL13 RXFP3 CX3CL1 ADRA2A CCR9 CXCL5;CXCL6 AGTR2 CCR8 FPR1 CCR7 SSTR3 CCR4 GALR3 CCR3 GALR2 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 GALR1 NPBWR1 NPBWR2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 GPR183 CCL5 PNOC CXCR2 GPR18 CCL1 CCL19 RHO CCR10 CCL16 CCR1 GPR37 CCL25 CCL21 CCL20 PPBP RGR CXCL10 CXCL11 CCL28 CCL27 ACKR3-2 PPP2CB;PPP2CA P2RY12 P2RY13 PF4;PF4V1-1 PPP2R5D P2RY14 PPP2R1B GPR55 MTNR1A MTNR1B RLN3 INSL5 P2RY4 APLN RRH GNAT1 GPR37L1 TAS2R42 ADRA2B PENK PPY PPP1R1B CDK5 PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GAL OPRD1 NPB PTGER3 NPW HCAR1 PDYN HCAR2;HCAR3 NPY2R NPY RGS8 CAMK4 NPY1R PCP2 APLNR SUCNR1 OPN3 PDE4D-1 RGSL1 OPN5 PYY GPSM1 GPSM2 GRM3 OPRM1 HEBP1 CAMK2B GRM2 CAMK2D CENPS-CORT;CORT;CENPS CAMK2A LPAR1 GRM7 LPAR2 GRM6 LPAR3 CXCL12 GPER1 FPR2 GRM8 CAMK2G PDE4A GPSM3 GPR17 NPY5R PDE4C OPRK1 SSTR1 LPAR5 SSTR2 NMS SSTR4 NMU SSTR5 RGS14 OPRL1 CNR2 CNR1 RGS20 S1PR3 RGS22 S1PR2 S1PR5 S1PR4 RGS10 ANXA1 RGS12 CX3CR1 KNG1 CCR6 AHCYL1 CCR2 PRKX MAPK1 PMCH RGS4 RGS5 RGS3 RGS1 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription RB1 DDX5 ZCRB1 VHL ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME ABCB1 ADAL NT5C2 ABCG2 SLC22A2 PCK1 ADH1C;ADH1B;ADH1A SLC22A1 SLC22A3 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle E2F2 CDK6 CDKN1A CDKN1B ATRX CCND1 CCND3 CCND2 ANAPC15 ANAPC16 DAXX UBE2D1 ANAPC10 CDK4 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 SKP2 TFDP1 UBE2S TFDP2 CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 RB1 ANAPC1 ANAPC2 CDKN1C E2F1 E2F3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT USP8 WNT9A SFRP1 SFRP2 WIF1 SOST AKT2 CSNK2A1;CSNK2A3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP CSNK1G2 USP34 PSMD12 KAT5 RYK-1 PSMD11 WNT5A PSMD14 PSMD13 SMARCA4 LEF1 WNT1 H2AC20 PSMA7 FZD1 PSMD8 H2AB2;H2AB3;H2AB1 FZD2 FZD5 PSMB6 FZD4 PSMB7 PSMD6 FZD6 PSMB4 PSMD7 FZD8 PIP5K1B ASH2L PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 RSPO3 PSMA1 PSMC4 PSMC1 CTNNB1 H2AJ TCF7 CDC73 TERT LEO1 BCL9L SOX3 TLE4 TLE3 SOX6 TLE2 SOX7 TLE1 SOX4 AXIN2 TCF7L1 PYGO1 WNT3A SOX13 BCL9 PYGO2 HECW1 SOX2 CCDC88C RSPO2 XPO1 RSPO1 H2BC5 RSPO4 AKT1 UBA52 H2BC1 LGR6 LGR5 LGR4 CTNNBIP1 KLHL12 CBY1 YWHAZ DACT1 ZNRF3 AMER1 PPP2CB;PPP2CA WNT8A AXIN1 WNT8B PPP2R5B PPP2R5A EP300 PPP2R5D PPP2R5C RPS27A FRAT2 PPP2R1B MEN1 APC H2AC4 PPP2R5E UBB;UBC SOX17 KMT2B LRP5 LRP6 TPTEP2-CSNK1E;CSNK1E RBX1 GSK3B CAV1 DPY30 SOX9 WNT4 CHD8 CSNK1A1 H2BC21 TNKS WDR5 TNKS2 RNF146 H2AZ2;H2AZ1 WNT3 SMURF2 DKK1 DKK2 DKK4 CUL3 MYC HDAC1 CSNK2A2 TRRAP RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RNF43 RUNX3 H2BC15;H2BC3;H2BC11;H2BC12 SRY TCF7L2 KREMEN1 KREMEN2 CTBP1 RUVBL1 DVL1 DVL2 DVL3 H2AC14 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 CDK1 CCNB2 CCNB1 NEK9 NEK6 PLK1 NEK7 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry AKT2 AKT3 CDK7 CCNA2-1 CCNA1 MNAT1 CKS1B PSMD12 PSMD11 PSMD14 CDC25A PSMD13 CDC25B PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 RBL2 TFDP2 PSMB1 CABLES1 PSMD1 WEE1 ADRM1 MYC PSMC2-1 E2F1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 RBBP4 PSMC4 PSMC1 SKP1 MAX CCND1 LIN54 LIN37 LIN9 LIN52 AKT1 UBA52 CUL1 PTK6 CDK4 CDK2 FZR1 RPS27A E2F5 UBB;UBC CCNE2 CCNE1 RB1 CCNH ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PTPN6 CD19 BLK PLCG2 BLNK BTK DAPP1 CD22 CALM3;CALM1 NCK1 PIK3AP1 LYN ITPR1 ITPR2 STIM1 ITPR3 ORAI2 ORAI1 CD79B CD79A SH3KBP1 PIK3CD AHCYL1 SYK VAV1 PIK3R1 FYN TRPC1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib SLC37A4 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 AVP SLCO4C1 SLCO2B1 SLCO1A2 SLCO2A1 SLC16A2 SLCO1C1 SLCO4A1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs ALOX12 PTGS2-2 ALOX5 ALOX15 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis PLA2G4A GNA13 MGLL JCHAIN PDPN MPIG6B GP6 STXBP3 STX4 CD84 SDC4 SDC2 ITGB2 SDC3 APP P2RX7 TSPAN7 SDC1 EGF PICK1 PLCG1 RAB5A RAP1B PRKACA-1 HGF PRKG2 DOCK7 ANO6 PPP2R1A MAFK ANO5 PRKCE APOA1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GPC1 GPC3 TUBA4A GPC2 GPC5 MYB GPC4 HBG2;HBG1 GPC6 KDM1A JMJD1C DOCK10 DOCK11 KIF5B KIF5A KIF21A PRKAR2B KIF21B KIFAP3 KIF4B;KIF4A AGRN KIF16B KIF20A KIF20B ZFPM2 ZFPM1 GATA6 GATA5 AK3 GATA4 GATA2 KLC1 GATA1 PHF21A KLC4 GUCY1A2 KLC3 GUCY1A1 KLC2 GUCY1B1 PDE1B RACGAP1 PDE1A KIF3B MICAL1 PDE2A IRAG1 KIF3C CYB5R1 CARMIL1 PDE11A NFE2 PDE10A KCNMB1 EHD1 VPREB3 KCNMB2 EHD2 VPREB1 KCNMA1 KIF18A KCNMB3 EHD3 SLC16A8 KCNMB4 SLC16A3 KIF18B FCAMR MAFG NOS1 IGLL5;IGLL1 MAFF PDE9A GYPC RCOR1 ITGA2 CD99L2 DOCK6 GLG1 ITGA10 DOCK5 SELE DOCK4 SELP DOCK3 ESAM DOCK9 SPN DOCK8 KIF12 CD48 KIF11 SELPLG KIF15 CD2 CD244 AKAP10 KIF19 CAPZB KIF13B HMG20B BSG CAV1 KIF1C KIF1B KIF1A JAK2 KIF25 KIF23 KIF22 RBSN HSPG2 KIF6 KIF27 RAD51B KIF9 RAD51C KIF2A KIFC2 KIFC1 PDPK1 IRF1 IRF2 KIF2C KIF2B DOCK2 HBD;HBB AKAP1 CDC42 MFN1 P2RX4 MFN2 SH2B3 A2M SH2B2 SH2B1 CABLES1 CABLES2 SERPINF2 CENPE PLAUR WEE1 KIF26A PLAT SERPINB8 CAPZA1 KIF26B PLAU HRG CAPZA2 SERPINB6-2 S100A10 IFNB1-4 PTPN11 VPS45 TIMP1 SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 CD74 ATP2B2 ATP2A1 MMP1 NOS2 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 ACTN2 CFL1 ITGAL CD44 SERPINB2 GNGT1 ANXA2 ITGA4 PPIL2 MIF PLG SOD1 ITGA5 KLKB1 SLC7A11 SLC7A10 TTN-1 GNA14 GNG10 GNA15 GNG2 GNG5 NOS3 GNG4 GNA11 GNG8 YES1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 VEGFA GNAQ GNB2 RAB27B GNB1 GNB4 GNB3 GNB5 ISLR HABP4 CHID1 GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 SERPINE1 LY6G6F;LY6G6F-LY6G6D ENDOD1 PECAM1 APOH VTI1B MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 CTSW TIMP3 ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD LHFPL2 PCYOX1L FAM3C LEFTY2;LEFTY1 APLP2 TMX3 RAC1 SELENOP SCG3 RARRES2 CYRIB SCCPDH RHOA LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CRK CDC37L1 DOCK1 BRPF3-1 P2RX6 P2RX5 P2RX3 STIM1 ITGA2B PTPN1 P2RX2 P2RX1 ORAI2 ORAI1 CDK2 BCAR1 ABCC4 P2RY12 PF4;PF4V1-1 TGFB2 TGFB3 ABL1 MPL THPO ADRA2B CBX5 ITGAV CDK5 MAG ACTN4 SIN3A GP1BA PIK3CG TRPC7 TRPC6 PRKCH TRPC3 HDAC2 THBS1 HDAC1 PTGIR ANGPT4 ANGPT2 ANGPT1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DOK2 TEK GRB14-1 SHC1-1 PRKCQ SERPINE2 ITGB3 LRP8 PROS1 RASGRP2 F13A1 RASGRP1 SERPINA5 THBD LYN CD177 FGB FGA GP1BB F2R TREM1 FGG F2 F3 F5 F7 PROCR F8 CXADR F9 SERPING1 SERPINC1 CLU KNG1 SERPIND1 JAML F10 F2RL2 F12 F2RL3 F11 DGKG GP5 DGKE GP9 OLR1 DGKD PROC F13B DGKB RAP1A DGKA MAPK1 MAPK3 ABHD12 CD99 DGKZ SOS1 DGKQ DGKK DGKI DGKH PIK3R3 ABHD6 PIK3R6 PIK3R5 APOB SELL DAGLA DAGLB FCER1G P2RY1 PAFAH2 AAMP AHSG SMPD1 ITGA6 CD47 ATP1B2 ATP1B1 LAMP2 SLC7A5 RAF1 SIRPA;SIRPB1;SIRPG AKT1 STXBP2 PRKCD RAPGEF3 PRKCA RAPGEF4 YWHAZ ADAMTS13 VWF ITGAM MAPK14 PRKCB TF CLEC1B PDGFB GNAS-1 PRKAR1B PRKAR1A PRKCZ ORM2;ORM1 QSOX1 LCP2 CD63 PRKACB-1 ATP1B3-1 KIF3A PRKAR2A TBXA2R GNA12 A1BG F11R FN1 SERPINA3 IGF1 GNAT3 SYK FGR HRAS GNAI3 FYN NRAS FLNA CFD PLCG2 SERPINA1 ARRB1 ITGA1 ITPK1 L1CAM CD9 APBB1IP GAS6 EPCAM CAP1 CD109 PRKCG ITPR1 ITPR2 LCK ITPR3 TLN1 SRC PSAP ARRB2 ALB GNAI1 CSK SPARC GNAI2 PCDH7 ADRA2C JAM2 ADRA2A JAM3 ACTN1 PFN1 HSPA5 GRB7 PTK2 ITGAX PPBP ITGA3 SLC16A1 PPP2CB;PPP2CA PPP2R5B PPP2R5A VAV3 PPP2R5D PPP2R5C PPP2R1B RHOG PPP2R5E VAV1 VAV2 RHOB MMRN1 MERTK APOOL ITGB1 GATA3 INPP5D SLC3A2 VCL IGF2 LAT PPIA TP53 PIK3R2 PIK3CB PIK3R1 ALDOA PIK3CA PTPN6 TGFB1 PDE5A AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels HCN4 HCN3 HCN2 HCN1 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress RPS14 RPS17 RPS16 RPS19 RPS18 AKT2 AKT3 CSNK2A1;CSNK2A3 HSPE1 RPS11 RPL10A RPS10 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 BMI1 CAPZA3 ETS1 ACTR10 RING1 PGD ZBTB17 RNF2 HDAC6 DCTN6 DCTN5 DCTN4 CBX8 CBX6 PHC2 PHC1 CBX4 RPS25 CBX2 RPS27 TXNIP RPS29 PHC3 RPS20 SKP2 RPS21 RPS24 EGF NFYA-1 RPS23 RPL36AL-1 YWHAE HSPB8 HIKESHI GFPT1 CCAR2 DNAJC2 DNAJC7 ST13;LOC107986532 CRYAB RPS19BP1 HSPA4L HSPA14 ACTR1A HSPA13 DNAJB1 PDGFA HSPH1 BAG5 MAFK AREG DNAJB6 BAG3 NFE2L2 BTRC BAG1 HSPA1L HSPA4 APOA1 SKP1 HSPA6 HSPA12A EEF1A1 HSP90AA1 HSPA12B RPS27L RPS15A RPS3 AQP8 AJUBA UBA52 RPS2 DYNC1I2 DCTN2 DCTN3 CUL1 RPL18A FAU ATF3 VCP-1 RPS27A RPS6KA3 RPS6KA2 UBB;UBC RPS6KA1 RPS9 RPS7 MAP2K3 RPS8 DYNC1H1 MAP2K4 RPS5 MEF2C RPS6 MAPKAPK3 MAPK9 RPSA MAPK8 MAP2K7 HSP90B1 MAPK10 TXN HELZ2 STAT3 MAFG BCL2 DDIT3 ACD TINF2 TERF2 BCL2L1 POT1 CREB3 DCSTAMP TERF2IP CREB3L3 TERF1-1 CREB3L4 CREB3L1 CREB3L2 CREBRF NLRP3 CAPZB SQSTM1 GSK3A HSP90AB1 RPS4X RPS3A HBD;HBB IL1A NFYB NFYC CAPZA1 CAPZA2 VHL IFNB1-4 RPL15-1 HIRA EIF2S2 FOXO3 EIF2S3;EIF2S3B EIF2S1 ATP6V1H LMNB1 IDH1 ATF5 GSTA3;GSTA1 NPRL2 NPRL3 EIF2AK1 EIF2AK4 H1-0 H1-3 H1-2 H1-5 SOD2 H1-4 SOD1 NOX5 EXTL1 EGLN1 EGLN3 EGLN2 CASTOR1 WTIP CASTOR2 ERO1A FBXL17 BACH1 SESN1 MAP3K5 MUL1 ARFGAP1 IMPACT CCNE2 HM13 CCNE1 RB1 SH3BP4 SRPRB-1 SLC7A11 NUDT2 EHMT2 EHMT1 PREB KDELR3 H2AC14 OMA1 DELE1 FKBP14 HERPUD1 MYDGF MINK1 DEPDC5 MED1 YIF1A HDGF ETS2 ERN1 HTRA2 GCN1 HMGA2 CABIN1 GOSR2 SOD3 CCS BMT2 TSPYL2 DDX11 ASF1A SEH1L H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VEGFA ABCF2-H2BE1;ABCF2 PPARGC1A PRDX3 SSR1 CREBBP ATF2 WDR59 PRDX6 HIF3A MIOS KAT5 WDR24 UBN1 CDKN2D CDKN2C EPO H2AC20 ERF RRAGA TNIK RRAGC RRAGB H2AB2;H2AB3;H2AB1 IGFBP7 EZH2 WFS1 RRAGD RPL10;RPL10L-1 TPP1 SRXN1 HIF1AN GPX6 CAT PRKCI GPX5 GPX8 PRDX2 GPX7 WIPI1 TFDP1 CTDSP2 PRDX1 TFDP2 CEBPG DNAJB9 FNIP1 FNIP2 NCOA1 TXNRD2 NCOA2 DNAJA4 E2F1 LONP1 NCOA6 E2F3 C12orf66 LIMD1 UBXN7 JUN ATM ITFG2 KPTN MAP4K4 ATR TATDN2 MAPK7 SZT2 CDKN1A UBE2D3-1 SIRT1 PDIA6 CDKN1B PDIA5 HSBP1 DPP3 RPLP0 NCOR2 HSF1 KLHDC3 DNAJA1-1 BRCA1 H2AJ SRPRA FLCN RPTOR ATF6B NCOR1 RPLP2 RPL36-1 FOS CDKN2B SUZ12 H2BC5 EPAS1 SIRT3 H2BC1 ATF4 STAP2 RPA1 PTK6 RPA2 NPLOC4 CDK4 CDK2 ID1 UFD1 CYCS-1 EXTL2 IGFBP1 RPA3 EP300 LAMTOR2 LAMTOR1 LAMTOR4 H2AC4 ADD1 LAMTOR3 LAMTOR5 EXTL3 MRE11 TBL1XR1 SESN2 NBN FABP1 CDK6 MAPKAPK5 MDM2-2 RPL22L1 SLC38A9 MAP2K6 RPL37A-1 GSK3B RHEB PPP1R15A HSPA2 CITED2 MDM4 SIN3A H2BC21 EED MLST8 H2AZ2;H2AZ1 COX4I1 COX4I2 ME1 ARNT FKBP4 CAMK2B CAMK2D CAMK2A RPL13A-1 SMARCD3 HDAC3 HSPD1 CXXC1 CAMK2G MTOR RAD50 RBBP4 NRIP1 LY96 CRTC1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TLR4 SHC1-1 H2BC15;H2BC3;H2BC11;H2BC12 UBE2D3;UBE2D2 NDUFA4 RPL23A ATP7A DEFA6;DEFA4;DEFA5 MAPK1 MAPK3 GRB10 P4HB APOB EP400 CCNA2-1 CCNA1 ATOX1 KDM6B RPL27A PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 CLOCK PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 PSMC3 ATP6V1E2 PSMA1 ATP6V1G1 PSMC4 ATP6V1G2 PSMC1 G6PD ATP6V0D1 ATP6V0D2 HSPA1A;HSPA1B ATP6V1A XPO1 KHSRP AKT1 NUP214 DIS3 PRKCD ATP6V1D MAPKAPK2 ATP6V1C1 ATP6V1F PARN GSTP1 EXOSC7 GCLC ATP6V1C2 EXOSC6 GCLM EXOSC5 CHD9 EXOSC4 RPL12-1 EXOSC9 SYVN1 EXOSC8 DCP2-1 EDEM1-1 EXOSC3 EXOSC2 EXOSC1 HSPA8 MAPK14 MAPK11 TCIRG1 CRTC2 CRTC3 ATP6V0B RAI1 BLVRB CLEC1B DYNC1LI1 MEF2D DYNC1LI2 ATP6V1B2 ATP6V0C BLVRA RBX1 ATP6V1B1 NRF1 NPAS2 MBTPS1 RPL26L1 MBTPS2 RPL4 RPL30 ATP6V1G3 RPL3 AKT1S1 RPL32 RPL31 RPL34 RPL8 SP1 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 RPL35 RPL38 RPL39 HYOU1 RPL21 RPL23 RPL22 CUL3 RPL24 RPL27 RPL26 E2F2 RPL29 RPL28 NUP107 PRKAA2 NUP188 NUP210 RPL3L NUP93 NUP205 RPLP1-2 AAAS DNAJB11 NUP160 NUP85 TPR NUP88 NCF1 NCF2 NUP155 NCF4 TALDO1 NUP153 TRIB3 ELOC-1 RPL11 NUP62 RPL14 ELOB RPL13 STIP1 RPL18 RPL17 RPL19 NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 COX7B NUP42 DNAJA2 COX7C NUP43 COX8A RAE1 COX8C RANBP2 TLN1 ASNS COX5B LMNA NUP35 ALB COX5A NUP37 RPL7A GPX1 COX6C CXCL8 COX6A1 HSPA5 COX6A2 CCL13;CCL2 EIF2AK3 TXNRD1 TXN2 RPL35A ATF6 FKBP5 SLC46A1 COX6B2 KEAP1 COX6B1 NOX4 CHAC1 AMER1 TRIM21 CALR-1 PPP2R5B HIGD1A STOML2 PHB2 YME1L1 PGRMC2 CA9 SEC31A DYNC1I1 TGS1 RORA NR3C1 CHD6 ESR1 NR3C2 AR RXRA PGR CARM1 DCTN1 PPARA TP53 HBA2;HBA1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYBB CYBA HIF1A CUL7 MYC COX7A2L-1 JMJD7-PLA2G4B;PLA2G4B CUL2 ARNTL TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 NQO1 HMOX1 AGO3;AGO1 HMOX2 TNRC6B NR1D1 CSNK2B RPL5-1 BAG4 BAG2 ABCG2 COX7A2 HSPA9 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 ACADVL CDC27 TKT ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ABCC3 ABCC1 RPS15 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen GP1BA FCER1G ITGA1 ITGB1 ADAMTS13 VWF ITGA2 ITGA10 GP6 GP5 GP9 FYN LYN GP1BB DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection DPM1 DPM2 DPM3 SNRPD2 DNAJC10 SNRPD1 ELAVL2 P4HB SNRPD3 VIM MAP1LC3B2;MAP1LC3B-1 ATG14 SDC4 H2BC18 RPN2 SDC2 SDC3 RPN1 PIK3R4 SNRPE-2 DNAJC3-1 SDC1 MAGT1 IKBKE PTBP1 HNRNPH1 HNRNPA1-1 PRKG2 HNRNPM NEK2 CTNNB1 APOA1 HSP90AA1 CDC73 CANX LEO1 GPC1 HSPA1A;HSPA1B P4HA1 GPC3 RBMX P4HA2 ELAVL1 GPC2 XPO1 GPC5 P4HA3 UBA52 GPC4 GPC6 STAT2 XRN1 TJP1 STING1 AGRN VCP-1 RPS27A TUSC3 UBB;UBC KPNA2 HSPA8 PABPC1;PABPC3 EIF4G1 RPSA TMEM258 SNRPF SNRPB DDX5 OST4 MAVS HNRNPC OSTC STT3A STT3B HSPG2 HSP90AB1 KPNA4-1 DDOST HYOU1 DAD1 CPSF2-1 MBL2-1 ACOT2;ACOT1 ATL2 PIK3C3 NUDT21 BECN1 LY6E EIF4A2 FUS NACA SNRPG-2 EIF4A1 BCAS2 C1S HNRNPA0 HNRNPA3 NFKBIB GPKOW CDC5L KPNA1 EIF4E DHX9 GTF2F1 GTF2F2 SUGP1 TAOK1 PABPN1-1 MMP9 PEX19 TSG101 DNAJB11 PPIE CLINT1 FURIN SUN2 HNRNPF HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 HNRNPU HNRNPR NMT1 SNRPA1 WDR61 BTF3 HNRNPL HNRNPK HNRNPD RPL18 WDR33 H2AC14 GAS6 ISY1;ISY1-RAB43 PDCD6IP NCBP1 PHF5A AUP1 IPO7 PAPOLA TXNL4A SNRPN NCL-1 PLRG1 DNAJC8 CD33-1 POLR2A FIP1L1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A POLR2B SEC11C POLR2C SNRNP40 DNAJA2 POLR2D PPIL3 PPIL4 PPIL6 SRRM2 POLR2G COG1 POLR2I CRNKL1 DAXX CSTF3 CSTF2 H2AC20 NCBP2-1 HNRNPH2 MAPKAP1 EMC4 SPCS3 SPCS2 SPCS1 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 CPSF4 CPSF1 SNW1 CPSF3 CWC15 CGAS UBA7 RBM5 RPTOR HSPA5 TAL1 C4BPA C4BPB CLDN1 IFIH1 LOC110384692;C4A;C4B_2;C4B TRIM25 EXOC1 SF3B1 GRPEL1 H2BC5 GBF1 AP2A1 H2BC1 AP2B1 AP2A2 RICTOR PQBP1 AP2S1 NPLOC4 SRRT UFD1 CALR-1 KPNA7 KPNA5 KPNA3 NRBP1 SNRNP200 H2AC4 ATG7 FASN CTNNBL1 PRCC MERTK KDELR1 CCAR1 U2AF1L5;U2AF1 EIF4A3 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK CDC40 RBM10 SCAP PAF1 SRRM1 RETREG1 DHX15 DHX16 KPNB1 SRSF2 SRSF3 UBE2I SRSF5 SRSF6 SRSF7 SRSF9 WBP11 HNRNPUL1 H2BC21 SRSF1 RTN3 U2AF2 PRR5 DDX46 DHX38 DDX42 SRSF11 SUMO1 RBM17 DYNLT1 SRSF4-1 BUD31 ALYREF RBM22 MLST8 RNPS1 DDX23 CSTF2T RRBP1 SMNDC1 U2SURP CLP1 PIK3R1 YBX1 TYRO3 CAMK2B UBA6 CAMK2D UBA5 CAMK2A UBR4 MRC1 CAMK2G MTOR SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 LY96 DDX3X-1 SF3A3 SF3A1 SF3A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 XAB2 POLR2E RIPK1 CPSF7 CLEC5A POLR2F CD14 POLR2H VTN TLR4 BAG2 POLR2L CHERP PROS1 UBA3 EIF4G3 EIF4G2 H2BC15;H2BC3;H2BC11;H2BC12 EIF4E3 LYN UBA1 NFKBIA F2 CLEC4M;CD209-2 PUF60 SNRPB2 AQR CLU PRPF19 PCF11 H2AC16;H2AC11 MAPRE3 AXL HDLBP EFTUD2 PDIA3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN NGF BRAF NTRK1 RIT1 RIT2 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress ABL1 ITGB1 RAMP2 GNG10 GNAS-1 GNG2 ADCY9 GNG5 NOS3 GNG4 PRKAR1B GNA11 ITGAV PRKAR1A GNG8 ADCY4 ADCY3 CAPNS1 ADCY2 ADCY1 CAPNS2 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 CAPN2 PRKACB-1 GNAQ GNB2 PRKAR2A GNB1 ADM GNB4 VCL GNB3 P2RY2 PRR5 GNB5 TLN1 CDH5 PDPK1 PANX1 CALCRL MLST8 PIK3CD MAPKAP1 PIK3R2 PIK3CB PECAM1 IKBKE FYN PRKACA-1 PPP2R1A PIK3CA MTOR TRPV4 KDR CTNNB1 CHUK CALM3;CALM1 IKBKB ITGB3 IKBKG MMP14 PKN2 PTK2 AKT1 PPP2R2A;PPP2R2D NFKBIA GNGT1 ANXA2 RICTOR STAT1 PTPN1 RELA PPP2CB;PPP2CA ITGA5 PRKAR2B YAP1-1 PPP2R1B NFKB1 FLT4 PIEZO1 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology HDAC1 CAMK4 WDR5 NCOR2 RBBP5 NCOR1 ASH2L CALM3;CALM1 TBL1XR1 DPY30 GPS2 KMT2D SIN3A HDAC3 PRKACA-1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F8 F9 F10 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism RPS14 RPS17 GNMT RPS16 AIMP1 MARS1 RPS19 RPS18 AIMP2 EPRS1 RPS11 RPL10A RPS10 RPS13 RPS12 RARS1 SECISBP2 RPL27A LARS1 SCLY EEF1E1 AHCY RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A INMT SARS1 RPLP0 RPLP2 TXNRD1 RPL36-1 RPL35A MAT1A RPS27L RPS15A RPS3 UBA52 RPS2 CTH NNMT KARS1 CBS;CBSL RPL18A FAU RPL12-1 RPS27A SEPHS2 RPS9 RPS7 RPS8 RPS5 EEFSEC DARS1 RPS6 RPSA RPL22L1 HNMT RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 QARS1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 IARS1 SEPSECS RPL23A PAPSS2 PAPSS1 RPL11 RPL14 RPL13 RPL18 RPL17 PSTK RPL19 RPS15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS BDNF SOS1 HRAS NRAS NTRK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages LAMA5 LAMA3 AREG CSF1 TGFA LAMA2 IFNG LAMA4 FN1 LAMB3 LAMB2 LAMB1 FGF2 FGF7 VTN LAMA1 EGF FGF10 PRL LAMC3 LAMC2 LAMC1 FGF4 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli GJA1 ABL1 ITGB1 RAMP2 GNG10 GNAS-1 GNG2 ADCY9 GNG5 NOS3 GNG4 PRKAR1B GNA11 ITGAV PRKAR1A CACNA1H GNG8 ADCY4 ADCY3 CAPNS1 ADCY2 ADCY1 CAPNS2 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 CAPN2 CACNB2 PRKACB-1 CACNB3 GNAQ GNB2 PRKAR2A GNB1 ADM GNB4 HSPG2 VCL GNB3 P2RY2 PRR5 GNB5 TLN1 CDH5 PDPK1 PANX1 CALCRL MLST8 P2RX7 PIK3CD MAPKAP1 PIK3R2 PIK3CB PECAM1 IKBKE CACNG7 FYN PRKACA-1 PPP2R1A PIK3CA MTOR TRPV4 KDR CTNNB1 CHUK CALM3;CALM1 IKBKB ITGB3 IKBKG MMP14 PKN2 PTK2 AKT1 PPP2R2A;PPP2R2D NFKBIA GNGT1 ANXA2 RICTOR STAT1 PTPN1 RELA PPP2CB;PPP2CA ITGA5 PRKAR2B SPP1 YAP1-1 PPP2R1B NFKB1 FLT4 CACNB1 PIEZO1 CACNA2D1 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching PRIM2 PRIM1 POLA1 POLA2 POLD3 POLD4 POLD2 RFC5 RFC3 RFC4 RFC2 RFC1 POLD1 PCNA REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling SPATA2 TNFAIP3 SHARPIN TBK1 USP21 USP4 ULK1 RACK1 MIB2 UBE2D3-1 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 CHUK BIRC3 CASP8 OPTN-1 RIPK1 FADD TNF IKBKB IKBKG UBE2D3;UBE2D2 UBA52 TRAF1 UBE2D1 MAPKAPK2 TAX1BP1 RPS27A UBB;UBC IKBKE SPPL2B SPPL2A CLIP3 STUB1 OTULIN RNF31 XIAP USP2 OTUD7B FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex NCBP1 CDK7 POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 NELFB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion HSP90AB1 SEMA3A PLXNA2 LIMK1 PLXNA3 PAK1 RAC1 HSP90AA1 FES PAK3 NRP1 FYN CFL1 PLXNA4 PAK2 PLXNA1 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ CBX3-1 ADNP2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ADNP H2AC4 CBX1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 USP8 PTPN18 GAB1 SOS1 MATK PIK3CA PRKCE AKT2 AKT3 HSP90AA1 YES1 NRG1 NRG2 GRB7 RHOA EREG BTC SHC1-1 NRG3 NRG4 MEMO1 DIAPH1 HBEGF AKT1 UBA52 PRKCD PRKCA PTPN12 PTK6 SRC RPS27A UBB;UBC EGF CDC37 ERBB2 ERBIN PLCG1 EGFR HRAS PIK3R1 RNF41 FYN STUB1 CUL5 NRAS COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface ATOX1 SLC11A1 PDZD11 ATP7A THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH10 MYO7A RDH12 RDH11 HSD17B6 RBP3 RPE65 TTR LRAT RDH5 RDH8 STRA6 HSD17B1 CYP4V2 RHO RBP4 RLBP1 ABCA4 SDR9C7 DHRS9 RBP1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2R1B PPP2R1A TFDP1 PRIM2 TFDP2 PRIM1 RB1 POLA1 POLA2 PPP2CB;PPP2CA PPP2R3B E2F1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes CDK1 SMC4 SMC2 NCAPG NCAPH NCAPD2 CCNB2 CSNK2A2 CCNB1 CSNK2A1;CSNK2A3 CSNK2B DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions SIGLEC5;SIGLEC14 SOS1 PIK3CA TREM2 GRAP2 PLCG2 KLRC4-KLRK1;KLRK1 RAC1 SIGLEC15 KLRC4;KLRC3;KLRC2;KLRC1 BTK B2M TYROBP KLRD1 LCP2 CLEC5A HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SIRPB1 TREM1 LCK VAV3 CD300E SYK PIK3R2 PIK3CB PLCG1 HRAS VAV2 PIK3R1 FYN NRAS RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SIRT1 PPARGC1A SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) RWDD3 SUMO1 SUMO3 UBE2I SUMO2 UBA2 SAE1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling CDC37 ERBB2 ERBIN HSP90AA1 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway FGF20 SOS1 SPTBN2 FGF23 MARK3 IL2RB PPP1CC RGL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 DLG1 EGF PSMD3 IL5 ERBB2 PSMB1 PSMD1 EGFR JAK1 PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PPP1CB PSMA5 RAP1B HGF SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A TYK2 PSMA3 MET PSMC6 PSMA4 PTPN3 AREG PSMC3 PSMA1 PSMC4 PSMC1 IL5RA FGF7 FGF22 FGF3 FGF10 RAF1 ICMT YWHAB KIT UBA52 ZDHHC9 VWF RPS27A UBB;UBC GOLGA7-1 CDK1 FLT3LG PDGFB RBX1 BCL2L1 KLB GRIN2B PDGFRB FGF19 FGFR4 JAK2 FLT3 LYPLA1-1 FN1 DUSP8 DUSP9 SPRED3 SPRED2 RASA4;RASA4B SPRED1 SYNGAP1 HRAS FNTA RASA3 RASA1 FYN RASA2 CUL3 RASAL1 NRTN RASAL2 RASAL3 NCAM1 NRAS DAB2IP PSPN NF1 GFRA2 KBTBD7 GFRA4 ARTN PTPN11 DUSP5 DUSP2 DUSP1 PAQR3 IL3RA PTPN7 CALM3;CALM1 ACTN2 CNKSR2 CNKSR1 PEBP1 GRIN2D IL6R EPGN ARRB1 DLG2 DLG3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RASGRF1 ABHD17C ABHD17B ABHD17A RCE1 SHC3 PTPRA NEFL SPTB LRRC7 IL2RA MAPK12 APBB1IP ARL2 TGFA SPTBN4 CSF2RB SPTBN5 CSF2RA MAP3K11 DUSP4 RASGRF2 GRIN1 DUSP6 DUSP7 GFRA3 IRS2 SHC2 RALGDS TLN1 SPTA1 IL2 IL3 SRC IQGAP1 ARRB2 CSK FNTB;CHURC1-FNTB NRG1 NRG2 ARAF EREG BTC RASGRP3 NRG3 NRG4 SPTBN1 WDR83 RGL3 PDE6D RGL2 HBEGF PEA15 PTK2 IL17RD RAPGEF2 PPP5C RASGEF1A CSF2 ITGA2B PPP2CB;PPP2CA SPTAN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B LAMTOR2 PPP2R5E LAMTOR3 PHB KSR1 KSR2 RET FGF2 VCL GFRA1 GDNF IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG CAMK2B BRAP CAMK2D CAMK2A JAK3 FRS2 PIK3CA CAMK2G MRAS RANBP9 ANGPT1 KRAS TEK SHC1-1 PRKCQ ITGB3 RASGRP1 RASGRP4 DUSP16 DUSP10 FGB FGA DLG4 FGG MAP2K2;MAP2K1 IL6 RAP1A MAPK1 BRAF MAPK3 SHOC2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway AKT2 AKT3 CSNK2A1;CSNK2A3 MAP1LC3B2;MAP1LC3B-1 SOD3 ABCF2-H2BE1;ABCF2 PGD CREBBP PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 SRXN1 PSMB4 PSMD7 PRKCI PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PALB2 EGF PSMD3 PRDX1 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 UBXN7 PSMA6 PSMC5 PSMA3 PDGFA PSMC6 MAFK PSMA4 AREG BTRC NFE2L2 CDKN1A PSMC3 PSMA1 DPP3 PSMC4 PSMC1 SKP1 BRCA1 CCL13;CCL2 EIF2AK3 TXNRD1 G6PD AKT1 UBA52 KEAP1 PRKCD ATF4 CUL1 NPLOC4 AMER1 TRIM21 GCLC UFD1 GCLM EP300 VCP-1 RPS27A UBB;UBC SESN2 TXN RBX1 MAFG BCL2 BCL2L1 GSK3B SQSTM1 CHD6 SP1 ME1 CUL3 MYC CSNK2A2 PRKAA2 NQO1 HMOX1 CSNK2B ABCG2 IDH1 GSTA3;GSTA1 RELA TALDO1 TKT CDKN2A FBXL17 BACH1 SESN1 NFKB1 MUL1 SLC7A11 ABCC3 ABCC1 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells DYNC1LI1 SPTBN2 DYNC1LI2 KIF18A CTSO ACTR1B CTSH CTSF CTSE CTSC HLA-DMA HLA-DMB KIF11 DYNC1I1 KIF15 CAPZA3 CTSA ACTR10 CAPZB HLA-DOA HLA-DOB KIF3A KIF23 KIF22 DCTN6 DCTN5 HLA-DPB1-1 DCTN4 KIF2A HLA-DQB2;HLA-DQB1 OSBPL1A HLA-DPA1 RILP KIF2C HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 KIF2B DCTN1 HLA-DRA CENPE KIF26A CAPZA1 CTSS CAPZA2 ACTR1A CTSK CTSD CTSB CTSV;CTSL RAB7A DYNC1I2 DCTN2 DCTN3 KIF5B KIF5A KIFAP3 KIF4B;KIF4A KIF20A KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 IFI30 KIF3B KIF3C REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex CRY1 TPTEP2-CSNK1E;CSNK1E ARNTL CSNK1D CLOCK PER2 CREBBP PER1 KMT2A NPAS2 CRY2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression SAP130 SUDS3 SAP30BP CDK7 MNAT1 BAZ2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIN3B SIN3A H2BC21 SMARCA5 UBTF DNMT3B H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 HDAC2 HDAC1 TAF1D TAF1B TAF1C SAP30L H2AJ TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H POLR2L H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 MBD2 H2BC1 ERCC2 GTF2H1 GTF2H3 GTF2H4 ARID4B TTF1 H2AC4 SAP30 CCNH DNMT1 H2AC14 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle UACA DBN1 STOM NSFL1C PAK1 WDR11 SLC4A7 TMEM59 VANGL1 PAK5 PAK4 RAB7A JUP CAV1 PAK2 OSBPL11 NIPSNAP2 MTR-1 LCK BUB1B-PAK6;PAK6 ROCK2 ARHGDIG RALGAPA1 VCP-1 FAM91A1 TFRC RHOH LAMTOR1 ARHGDIA VAMP3 ARHGDIB DBT CSK ZAP70 ROCK1 SLC1A5 GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation CXCR4 IHH CREBBP PAX6 MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 LEF1 FOXA2 RBPJ DLL1 PSMA7 DLL3 PSMD8 LFNG PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 NOTO PSMB1 PSMD1 SOX1 HES7 MAML3 EPHA4 ZIC2 OTX2 ADRM1 POU3F1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 SNW1 PSMA3 PSMC6 MAMLD1 PSMA4 RIPPLY2 PSMC3 FGFR1 PSMA1 PSMC4 TEAD2 PSMC1 KAT2B CTNNB1 TCF7 TEAD4 KAT2A TCF7L1 WNT3A DLX5 POU5F1;POU5F1B PAX3 SOX2 PAX7 ZIC1 MYB MSX1 FOXF1 FGF8 EP300 FOXH1 GATA6 GATA4 ZEB2 EOMES TBXT NANOG;NANOGP8 SOX17 GSC TBPL2 MIXL1 SNAI1 FOXC2 FOXC1 ZNF521 FGF2 NOG CDH1 OSR1 PAX2 BMP4 PAX8 LHX1 SHH SMAD4 FOXA1 TFAP2A TFAP2C TFAP2E;TFAP2B YAP1-1 TCF7L2 FGF4 TRIM33 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MOGS MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLC34A2 SLC34A1 PDZD11 SLC4A7 SLC26A11 SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC26A2 SLC6A4 SLC26A1 SLC35B4 LCN15 LCN12 APOD SLC35A2 SLC35A3 SLC33A1 SLC35C1 ARL2BP LCN1 SLC27A6 SLC29A4 SLC28A2 SLC25A5 SLC29A1 SLC28A1 SLC29A3 SLC27A4 SLC29A2 SLC17A8 SLC28A3 SLC25A6 SLC2A8 SLC30A3 SLC30A2 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC5A6 SLC7A5 SLC5A7 SLC10A6 SLC9A2 SLC9A3 SLC9A4 SLC35B3 SLC9A5 SLC9A6 SLC35B2 SLC9A7 SLC9A8 SLC9A9 SLC22A3 SLC22A8 SLC27A1 SLC25A1 SLC22A6 SLC5A12 SLCO2B1 SLC16A2 SLC13A5 SLC13A2 SLC22A4 SLC13A3 SLCO1C1 SLC22A5 SLCO4A1 SLC35D1 SLC35D2 SLC16A8 SLC16A3 SLC26A7 SLC26A9 SLC26A6 SLC14A1 SLC14A2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC47A1 BSG SLC25A26 SLC22A15 SLC5A9 SLC22A16 SLC30A10 SLC5A4 SLC2A11 SLC2A12 SLC13A1 SLC13A4 SLC5A10 SLC30A8 SLC45A3 SLC30A5 MFSD4B-2 SLC20A1 SLC31A1 SLC35A1 SLC41A2 SLC41A1 SLC2A6 SLC2A7 SLC50A1 SLCO4C1 SLC8A3 SRI SLC36A4 CALM3;CALM1 SLC6A7 SLC8A1 SLC8A2 SLC2A13 SLC5A11 SLC5A3 SLC32A1 SLC6A13 SLC6A1 SLC4A1 SLC4A4 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC7A1 SLC1A7 SLC7A3 SLC25A29 SLC38A3 ARL2 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC39A4 SLC38A1 SLC36A2 SLC6A15 SLCO2A1 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC26A4 SLC7A8 SLC26A3 SLC7A9 SLC5A8 SLC22A12 SLC22A18 SLC5A5 SLC24A5 SLC40A1 SLC22A2 HEPH SLC22A1 SLC6A9 SLC17A6 SLC17A7 SLC5A2 SLC16A7 EMB CP SLC16A1 SLC6A12 SLC6A11 SLC12A3 SLC12A1 SLC12A6 SLC3A2 SLC24A2 SLC5A1-1 SLC9A1 SLC24A3 SLC8B1 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLCO1A2 SLC2A9 SLC25A18 SLC6A5 SLC6A2 SLC25A10 SLC6A3 SLC25A4 SLC2A10 SLC25A11 RUNX1 FGF21 CTNS SLC24A1 SLC24A4 SLC25A22 SLC2A4 SLC11A2 SLC44A5 SLC2A1 SLC2A2 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC17A5 AVP SLC15A1 SLC11A1 SLC20A2 SLC15A3 SLC15A4 RSC1A1 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling EPHA5 ARHGEF7 EPHA7 EPHA6 EPHA8 MYL6 ARPC4 ARPC5 NGEF EPHA1 LIMK2 ARPC2 EPHA3 LIMK1 ARPC3 PAK1 EPHA10 YES1 MYL12A PSENEN ACTB-1 PAK3 GRIN2B GRIN1 NCK2 MYH9 SDC2 ACTR2 SDCBP ARPC1B ARPC1A ADAM10 EFNA5 WASL EFNA4 EFNB2 EFNB1 EFNB3 ROCK2 EFNA1 PSEN1 EFNA3 EFNA2 ACTG1 CDC42 NCSTN CLTB HRAS EPHA4 RASA1 FYN ROCK1 CLTCL1 ARHGEF28 MYH14 RAC1 MYH11 MYH10 RHOA MMP2 KALRN MMP9 MYL12B CFL1 EPHA2 CLTC LYN PTK2 CLTA AP2A1 PAK2 AP2B1 TIAM1 AP2A2 DNM1 ACTR3-1 AP2S1 GIT1 VAV3 PSEN2 ITSN1 APH1A VAV2 APH1B EPHB6 EPHB2 EPHB1 EPHB4 EPHB3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 ABCA3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation CHEK2 ATM SMYD2-1 MDM2-2 SETD9 TTC5 EP300 RPS27A L3MBTL1 TP53 UBB;UBC PRMT5 KMT5A EHMT2 JMY EHMT1 MDM4 UBA52 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 CCNE1 RB1 CDK2 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins CSNK2A1;CSNK2A3 MOGS H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A RPN2 SEC11C RPN1 PSMD12 PSMD11 PSMD14 PSMD13 SMARCA4 FOXA2 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 SRC EZH2 PSMB6 TGIF2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PCSK7 SPCS3 PSMD3 ANK3 SPCS2 PSMB1 SPCS1 PSMD1 BANP ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 SIRT1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 H2AJ TCF12 CANX PCSK6 TLE1 SUZ12 H2BC5 UBA52 H2BC1 KDM1A DNM2 MPHOSPH8 RPS27A H2AC4 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 MDM2-2 SNAI1 SNAI2 CTNNA1 CDH1 KLF4 OST4 JUP STRAP OSTC STT3A TWIST2 SP1 H2BC21 VCL PRKCSH EED DDOST H2AZ2;H2AZ1 WT1 ARID1A DAD1 GANAB MYC CTSS HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 ZNF217 TNRC6B CTSB CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 FURIN ZMYM2 CTBP2 CTBP1 MAPK1 POMT2 RB1 MAPK3 POMT1 H2AC14 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA NUP133 NUP107 NUP188 RANGAP1 NUP50 POM121;POM121C RCC1 NUP54 NUP210 NUP93 NUP205 NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 RANBP1 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) NSDHL DHCR24 HSD17B7 LBR DHCR7 CYP51A1 SC5D EBP MSMO1 TM7SF2 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 L3MBTL2 RBBP4 EPC1 MAX CBX5 BRCA1 BMI1 RBBP7 RAD51 RING1 PCGF6 SUZ12 PCGF2 RYBP RNF2 YAF2 CHEK1 EED PHC1 EZH2 CBX3-1 E2F6 APAF1 MGA PHC3 RRM2-1 TFDP1 TFDP2 EHMT2 EHMT1 UXT RBBP8 E2F1 CDC7 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling DCC TRPC7 PITPNA PLCG1 TRPC5 NTN1 TRPC6 TRPC3 TRPC4 TRPC1 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A TPTEP2-CSNK1E;CSNK1E RBX1 GSK3B CSNK1A1 PSMD12 CHEK2 PSMD11 CHEK1 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PLK3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 FBXW11 NEK11 UBA52 CUL1 RPS27A UBB;UBC MAPK14 MAPK11 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations POMT2 DAG1 POMT1 POMGNT1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development HDAC1 CALM3;CALM1 CAMK4 TBL1XR1 GPS2 NCOR2 NCOR1 SIN3A PRKACA-1 HDAC3 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm NOG CREBBP MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 BMP4 PSMD8 LFNG PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES7 MAML3 EPHA4 ADRM1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 SNW1 PSMC6 MAMLD1 PSMA4 RIPPLY2 PSMC3 PSMA1 FGFR1 PSMC4 PSMC1 KAT2B CTNNB1 KAT2A WNT3A EP300 TBXT METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins DPM1 DPM2 DPM3 ARSD-1 N6AMT1 RPL10A IDE RARS1 MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 RAB4A MRPL38 MRPL39 MRPS10 MRPL36 GCSH-3 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 RAB5A MRPL3 RPL36AL-1 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 HMGCS2 MRPS23 IDH3A MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 APOA2 MRPL48 APOA1 MRPS7 APOA4 MRPL46 MRPS6 MRPL43 APOA5 MRPS5 MRPS18C MRPL44 PDHB MRPL52 MRPL53 TTR MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 RAB14 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 RPL18A MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 PDK1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 SUCLG2 HSP90B1 LHB TXN PRKDC TMEM129 HLTF RNF152 SHPRH PEX10 PEX2 PEX12 PEX13 PEX14 RNF40 RNF144A SELENOS WAC-1 RNF181 INS;INS-IGF2 RAD18 APEH ACOT2;ACOT1 ATP5PF ATP5PD ATP5PO NDUFA13 HADH RPL15-1 ATP5MG IDH2 GLUD1;GLUD2 HK1 DBT TRAPPC2L RAB32 RAB31 TBC1D20 RAB35 RAB38 ALDH1B1 RAB6B TRAPPC3 TRAPPC1 TRAPPC4 TRAPPC5 RAB39A RAB27A RAB39B RAB27B TRAPPC9 UQCRC2 RAB8B TRAPPC2;TRAPPC2B RPL10;RPL10L-1 RAB33A TRAPPC6A TRAPPC6B RAB7B RAB1A RAB1B RAB21 GGA2 GGA1 GGA3 CHML TRAPPC10 GPIHBP1 RAB33B-1 RAB11B RAB10 CS RAB13 RAB18 ARF1 RPLP0 TRMT112 RPLP2 RPL36-1 ARG2 SUMF2 SUMF1 MITF BDH1 DLD VAMP2 FH KARS1 CLSPN GSN MDH2 RPL22L1 RPL37A-1 ACAT1 SRD5A3 MME COX4I1 NADK2 ME2 RPL13A-1 ST6GALNAC5 ST6GALNAC6 NDUFB6 FFAR4 HSD17B10 IARS1 GRP RPL23A ARSA STX1A ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSG CTSA RPL27A P2RY2 PCSK1 CDX2 GPR119 GIP DPP4 LEP ACAD8 ANK3 KDM8 OGFOD1 JMJD4 DHPS FN3KRP JMJD7 RCCD1 EIF5A2 DNAJC24 DPH1 DPH2 DPH5 DPH6 DPH7 ZC3H15 FN3K RWDD1 ICMT EIF5A;EIF5AL1 DOHH RIOX1 DRG1 DRG2 CPB2 NDUFV3 NDUFV1 CD59 CD55 DARS1 NDUFS3 MVD NDUFS1 MAT2B MBTPS1 RPL26L1 RPL4 POLB RPL30 RPL3 RPL32 RPL31 PCSK2 RPL34 ERO1B CTSZ KIF5C RPL8 ANPEP CPA3 RPL9 SLC30A8 RPL6 SLC30A5 FSHB RPL7 ATP6AP2 MYRIP GZMH-1 RPL35 ENPEP CPB1 PLA2G7 RPL38 CRHR2 CLTRN ACE IGF1 RPL39 MBOAT4 INHBC INHBE CPE REN RPL21 RPL23 RPL22 SMC5 PARK7 SMC6 DDX17 NSMCE3 FDX1 NSMCE2 RPL24 NSMCE1 HIC1 RPL27 EID3 ZBED1 RPL26 TP53BP1 RPL29 SP3 RPL28 TOP2A TOP2B ZNF131 SENP5 FOXL2 SENP2 SAFB NSMCE4A TOP1 SP100 UHRF2 RNF168-1 CASP8AP2 NOP58 RPL3L RWDD3 MBD1 RAD52 OGDH UBXN1 NGLY1 MLEC RPLP1-2 ENGASE CDH2 RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 USP8 AGT FECH ALB UBE2T RPL7A ADRA2C ADRA2A SARS1 RPL35A FOLR2 OXCT1-1 VDAC1 TFAM-1 TWNK ACADSB STAR SSBP1 QARS1 IGF2 FFAR1 DLAT SEC61A2 B3GNT7 B3GNT5 SEC61A1 B3GNT4 SEC61G SEC61B B3GNT3 PSME1 B3GNT2 SEC22B PSMB10 PSMB8 PSMB9 PPA1-1 ATP5F1A ATP5F1B ATP5F1C OXA1L HSPA9 B4GALT2 B4GALT3 VGF ALDH2 TSHB SPTBN2 MARS1 CTSH B4GALT6 CTSC B4GALT4 B4GALT5 CAPZA3 ACTR10 POMC DCTN6 DCTN5 DCTN4 APP NFKB2 TOMM20 VDAC2-1 SKP2 VDAC3 AARS1 HARS1 YARS1 WARS1 GARS1 NARS1 FARSA CARS1 TARS1 FARSB VARS1 AREG NFE2L2 EEF1B2-1 EEF1G EEF1A1 EEF1D EEF1A2 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 UCHL1 SENP8 UCHL3 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 BAP1 KIF5B KIF5A GATA6 GATA4 ANK1 CAPZB MAN1A2 MAN1C1 MAN1A1 CAPZA1 CAPZA2 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 HGS DCAF13 RAB7A PSME2 MUL1 ARFGAP1 SRPRB-1 PREB KDELR3 OMA1 HTRA2 GOSR2 MDC1 SSR1 HIF3A DAXX RRAGA IGFBP7 WFS1 BARD1 PRELID1 LONP1 UBXN7 CDKN1A PDIA6 DPP3 CHM BRCA1 SRPRA ING2 BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCC3 DDB2 PCNA WRN RPA1 HIPK2 USP7 IGFBP3 USP2 BLM MDM2-2 NPM1-2 MDM4 DCAF8 DCAF5 DCAF6 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 COMMD8 COMMD9 PUM2 DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 RABGGTB COMMD7 RABGGTA COMMD4 SPSB3 CCDC8 BIRC5 CUL9 UBD NAE1 SOCS6 SOCS5 AURKB WDTC1 CCDC22 DCUN1D2-1 COMMD10 DTL TULP4 PML DCAF16 DCAF17 CAND1 FEM1C DCAF10 DCAF11 FEM1A TRRAP FEM1B NEURL2 ERCC8 JMJD6 TADA2B PRMT3 H2AC16;H2AC11 KDM1B RUVBL1 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L ATXN7 RIOX2 H2BC18 CALB1 BACE1 MFGE8 APCS CALCA TSPAN33 USP22 CST3 TSPAN5 SNCA ODAM NAT8-2 SNCAIP SORL1 TSPAN15 TSPAN14 SLC35C1 TGFBI ITM2B SLC25A5 SLC25A6 MUC13 CKAP4 KTN1 ADAMTS13 MRTFA TF DYNC1LI1 DYNC1LI2 CDCA8 RHOT1 HNRNPC LRRC41 INCENP GPS1 LMAN1 STX5 YKT6 USP9X MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB TMED10 STX17 LMAN2L USO1 NAPG LMAN2 SEC31B ANKRD28 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 SPTB ANK2 COPS4 COPS2 SPTBN4 SPTBN5 ARFGAP3 ARFGAP2 SPTA1 DMP1 RNF20 MATN3 TNC CFTR SCFD1 SPTBN1 FBN1 STAM SPTAN1 LAMB2 DYNC1I1 PIAS4 HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 RAB9A ESR1 NR2C1 PIAS1 NR3C2 RAB9B NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA TP53 STAM2 STARD7 CSNK2A2 CSNK2B ACHE SENP1 CSNK2A1;CSNK2A3 ALPG;ALPP;ALPI-1 BMI1 YY1 RING1 BCHE SATB1 RNF2 HDAC7 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 PNPLA2 NAGK AMDHD2 GFPT2 GFPT1 PGM3 CETN2 GNPNAT1 UAP1 CCP110 RENBP OTUD7B PRKACA-1 ACTR1A TNFAIP3 TUBA1A USP21 USP4 BTRC CYLD RAB8A BIRC2 SKP1 BIRC3 CDC73 LEO1 FBXW11 CSNK1D AXIN2 TUBA4A UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA CSF1 MAN2A2 MGAT3 ST8SIA6 CHST8 CAMKMT ST8SIA2 FUCA1 ST8SIA3 RPS27A UBB;UBC DYNC1H1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TNIP2 CDK1 STAT3 ADAM10 HSPG2 ADAMTS16 NCSTN ADAMTS18 PLAUR LAMC1 ADAMTS4 ADAMTS5 GALNT2 ADAMTS1 KLK3;KLK2 CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 FOXO4 ATXN3 MMP1 MMP2 OTUB2 OTUD5 OTUD7A FBXO32 VCPIP1 TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 OTUB1 FURIN PLG SPP1 CMA1 LAMB1 H2AC14 TRIM28 L3MBTL2 TGFA HCFC1 SATB2 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CREBBP NPPA SMAD2;SMAD3 ADRB2 H2AC20 H2AB2;H2AB3;H2AB1 NCOA1 NCOA2 ACTL6A UBE2D3-1 NCOR2 KAT2B KAT2A SUZ12 H2BC5 MCRS1 PCGF2 H2BC1 TTF1 IGFBP1 EP300 MEN1 H2AC4 DNMT1 SUDS3 CBX5 PENK ACTB-1 TADA3 KLF4 CHD3 SIN3A PARP1 H2BC21 ZNF350;ZNF432 DNMT3B WDR5 DNMT3A H2AZ2;H2AZ1 KCTD6 SMAD1 SMAD4 SMURF2 SMAD7 HDAC2 HDAC3 THBS1 HSPD1 HDAC1 MTA1 RBBP5 TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 PROS1 H2BC15;H2BC3;H2BC11;H2BC12 FGA FGG F2 NOTUM F5 F7 F8 LYZ-1 F9 SERPINC1 KNG1 SERPIND1 F10 FUCA2 PROC EIF2AK2 TOPORS POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 C1GALT1C1 ADAMTS2 LTF ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON MUC3A MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 BPIFB2 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 PSMD12 GALNT3 MUC17 PSMD11 C1GALT1 MUC5B PSMD14 MUC20 PSMD13 MUC21 DNAJC3-1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 SRP14 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADA2 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 AHSG PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 RAB3D RAB44 PCCB RAB37 RAB4B RAB24 NUP214 COPB1 HSPA8 PABPC1;PABPC3 EIF4G1 ASPH RBX1 QSOX1 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN GNAT3 ADORA2B FCGR3A;FCGR3B CUL3 KBTBD7 USP18;USP41 C3-1 SAA2;SAA1 NUP107 NUP188 USP14 NUP210 NUP93 NUP205 ABCE1 AAAS NUP160 NUP85 ARRB1 TPR NUP88 NUP155 XRCC4 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 NUP153 RCE1 NAPA RARS2 AARS2 RAB5C PARS2 TGOLN2 MARS2 DARS2 HARS2 YARS2 ELOC-1 FARS2 WARS2 NUP62 LARS2 SARS2 ELOB NARS2 TARS2 IARS2 VARS2 CARS2 EARS2 NDC1 LIPT2 SEC13 NFU1 LIPT1 NUP133 LIAS PIGS CPM LY6K PIGU GOLGB1 PGAP1 RANGAP1 PIGT NUP50 SFTPB POM121;POM121C PSCA SFTPC PIGO PIGN NUP54 CSF2RB GPAA1 CSF2RA PIGP PIGZ MSLN PIGW PIGV PRSS21 PRND TECTB IZUMO1R RTN4RL2 CISH PIGC PIGB NUP42 PRL NRN1L RTN4RL1 CD109 PIGA SOCS2 LY6D PIGK NUP43 PIGM SPACA4 TAF9B PIGL RAE1 PIGG LY6H RANBP2 PIGF GPLD1 PIGH NRN1 NTM TEX101 TAF10 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 LYPD8 NUP35 ARRB2 ART4 OTOA LY6G6C OPCML NTNG1 NTNG2 NEGR1 CNTN5 NUP37 PIGX-1 LSAMP COP1 GP2 PLET1 PRSS41 XPNPEP2 LYPD6B ALPL VCAN CNTN3 MELTF GLB1 CNTN4 TECTA;TBCEL-TECTA MDGA2 RECK MDGA1 SPRN ARSB DDX58 SRP19 TRAM1 UBE2L6 SRP54 SSR4 SSR2 IFIH1 SSR3 SRP9 TRIM25 SRP72 SRP68 IKBKG LRR1 CCNF KEAP1 HERC2 GALNT11 GALNT14 AMER1 GALNT13 GALNT16 FBXO7 AXIN1 GALNT15 FBXO9 GALNT18 B3GALNT2-2 GALNT10 POFUT2 WSB1 FBXO2 EMID1 GALNT9;GALNT17 RNF123 FUT10 APC FUT11 GALNTL5 UBE2J2 GALNTL6 B3GNTL1 GALNT9 GALNT8 SPG7 POMGNT2 B3GNT9 SIAH2 B3GNT8 MMRN1 SIAH1 AFG3L2 B3GNT6 MMRN2 SMDT1 CHST4 YME1L1 FBXL8 GCNT1 FBXL4 GCNT3 FBXL7 PMPCA GCNT4 MICU2 GALNT7 GALNT6 GALNT5 GALNT4 MGAT5B-1 A4GNT POMK GAN PRKN GATA3 EIF5 GPR75-ASB3;ASB3-1 KLHL2 RAB2A KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 EIF5B KBTBD8 SPSB4 FBXO27 LTN1 UBE2Z FBXO21 FBXO22 BMP4 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 UBE2V2 HIF1A CUL7 CUL5 UBA6 MYC CUL2 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H UBE2B KLHL25 ALG5 ZBTB16 NUDT14 TGFB1 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBA3 TFAP2C UBA1 UBE2K TFAP2E;TFAP2B KBTBD13 UBE2Q2 GMPPB FPGT UBE2D1 RELA GMPPA GFUS DHRSX GMDS PMM1 FCSK UBE2R2 DOLPP1 TCF7L2 ALG10;ALG10B GFM2 CDKN2A MTRF1 UBE2C ASB13 MTRF1L ASB14 UBE2E1 MRRF ASB11 IL6 GOSR1 UBE2S RNF7 ASB12 ASB17 RCHY1 ASB18 FBXL22 ASB15 ASB16 COG8 FBXL20 COG7 ZDHHC2 COG6 RPS15 COG5 RPS14 COG4 COG3 ASB10 RPS17 COG2 BET1L RAB30 RPS16 RAB36 FBXL19 RPS19 FBXL18 FBXL15 RPS18 APOL3;APOL4;APOL1;APOL2 FBXL16 FBXL13 FBXL14 RPS11 FBXL12 B2M RPS10 ASB8 RPS13 ASB9 RPS12 ASB6 ST6GAL1 ASB7 MOGS ASB4 ACE2 ASB5 ASB2 RPN2 SAR1B ASB1 SDC2 RPN1 ST3GAL4 GOLGA2 CDC25A ST3GAL1 ST3GAL2 C12orf65 ST3GAL3 MIEF1 MALSU1 MTFMT EDEM2 MTIF2 MTIF3 MTRES1 GRIA1 RPS25 RPS27 RPS29 RPS20 NSF RPS21 RPS24 RPS23 ADORA2A MAGT1 IKBKE TOMM70 RIPK2 SFTPD ANO8 MYO5A CANX RPS27L RNF135 RPS15A MGAT5 RPS3 GPC3 MGAT1 RPS2 MGAT2 KLK13 SEC24D-1 FAU VCP-1 TUSC3 MAP3K7 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA OTULIN TUFM TMEM258 DDX5 FUT8 MAN2A1 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 MAVS OSTC USP30 SQSTM1 STT3A UBE2N ZNF598 ASCC2 ASCC3 STT3B TAB1 ST6GALNAC2 TRIM27 USP10 PRKCSH USP13 TNKS MGAT4A-1 RPS4X TNKS2 RNF146 OTUD3 RPS3A DDOST DAD1 TRAF3 TIMM17A-1 TRAF6 CHCHD2 ST6GALNAC1 OPA1 CMAS OXSM ECH1 MAN1B1 NPL NANP ST6GALNAC3 TIMM22 NEU4 ST6GALNAC4 CLPX BECN1 ST8SIA4 CLPP NANS SEC23A TIMM10 LDHD ST6GAL2 NOD1 ST8SIA1 ALDH18A1 GNE NOD2 GANAB EIF4A2 EIF4A1 VHL SEC24B SEC24A GALNT1 MGAT4C KDELR2 MGAT4B COPB2 COPA SEC24C COPE EIF4E EIF4B TMED3 TMED7 TMED9 COPZ2 COPZ1 CALM3;CALM1 ARF5 DCAF7 CCT6B ARCN1 PFDN4-1 COPG2 GNGT1 COPG1 TUBA1C KIF13A TUBB1 FBXO4 METTL21A LONP2 FBXO6 KIN RGS9 METTL22 ETFBKMT RGS6 RGS7 VCPKMT FAM86B1;EEF2KMT;FAM86B2 CCT3 FBXW4 EEF1AKMT2 CCT2 EEF1AKMT1 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS PFDN1 PFDN2 FKBP9 PFDN5 TUBB3;TUBB6 PFDN6 TUBAL3 GBA ARL2 GNA14 AP3M1 PSMD9 GNG10 GNA15 PSMD4 GNG2 PSMD5 GNG5 PAAF1 GNG4 PSME3 GNA11 PSME4 GNG8 PSMD10 PSMB11 CCT8 TUBA3E;TUBA3C-1 POMP PSMA8 CCT7 PSMF1 CCT5 PSMG3 CCT4 NOP56 PSMG4 ARFGEF2 PSMG1 PSMG2 TBCD TBCC TBCB TBCA USP5 GNG13 USP3 CCT6A GNAQ FKBP8 GNB2 SNX3 PAX6 TBCE USP37 GNB1 USP34 PDCL USP47 GNB4 IAPP USP48 GNB3 USP49 SKIV2L USP42 FBXL3 USP44 PTRH2 GNB5 USP26;USP29 RGS11 ARF4-1 FBXL5 USP16 WDR20 TUBA8 WRAP53 USP24 USP25 USP20 USP28 B4GALT1 TMED2-1 CALU SEL1L ST3GAL6 RAB6A SPP2 EXOC8 EXOC7 APLP2 SCG3 EXOC4 RHOA EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GBF1 EPAS1 RAB11A SOCS3 ANKZF1 KLHDC10 NPLOC4 TCF25 UFD1 NEMF UBA2 SAE1 VNN1 LTBP1 VNN2 APH1A APH1B INHBB INHBA CHRDL1 PSENEN MIA2 UCHL5 MIA3 TMEM115 USP15 FSTL1 FSTL3 INHA U2AF2 TPGS1 TTL TPGS2 SVBP ARPC4-TTLL3;TTLL3 TTLL12-1 AGTPBP1 LRRC49 NICN1 VASH2 VASH1 AGBL5 TTLL7 AGBL4 TTLL6 SMC3 TTLL5 TTLL4 RAD21 AGBL1 AGBL3 TTLL1 AGBL2 STAG1 TTLL11 TTLL9 STAG2 SMC1A NRIP1 TRAF2 RIPK1 CDC34 NFRKB BCL10 ACTR5 RAD23A UBE2D3;UBE2D2 ACTR8 NFKBIA RAD23B DDB1 INO80C INO80B INO80E INO80D COPS7B COPS7A XPC TFPT INO80 TGFBR1-1 CUL4A COPS3 TGFBR2 COPS6 COPS5 COPS8 CUL4B PCSK9 FGF23 SLC34A2 SLC34A1 P4HB APOB ISL1 CDC20 GSPT2 GSPT1 CCNA2-1 CCNA1 USP33 ETF1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H LARS1 EIF3E EIF3F EIF3D EIF3A EIF3B SHMT2 JOSD2 JOSD1 COL7A1 RAB3A DLST RPL12-1 EDEM3 AMFR SYVN1 DERL2 EDEM1-1 RNF5 RNF103 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 ABRAXAS2 TPST2 MYSM1 STAMBPL1 TPST1 STAMBP IL33 UQCRQ ACO2 ALAS1 PTEN FN1 ETFB UMOD ASGR1 ASGR2 MANEA LY6E ALG8 ALG9 LGALS1 ALG6 AMELY;AMELX ALG2 ALG3 EVA1A ALG1 CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 IGFBP6 AMBN ECI1 DHDDS TMEM132A HRC PRSS23 BMP15-1 STS MEPE RCN1 ENAM AMTN VWA1 FAM20C FAM20A PAPPA2 ITIH2 AFP GOLM1 PPA2 NUCB1 CES1 TFG NEU2 NEU3 CTBP1 NAPSA WDR61 CCDC59 PGA4;PGA3;PGA5 NEU1 ADGRF5 LMCD1 APOE HNRNPK B4GALNT2 WDR48 GAS6 AIMP1 BST1 AIMP2 EPRS1 RAB5B RAB22A RAB40C RAB3B RAB3C SEC11A RAB42 SEC11C RAB2B RAB34 PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB29 COG1 RAB15 RAB19 RAB17 MSRA PCMT1 EEF1E1 MSRB3 MRPS36 COX5B COX5A SPCS3 SPCS2 SPCS1 ALG14 ALG12 ALG11 GCG NDUFAB1 RFT1 LOC110384692;C4A;C4B_2;C4B ABCA3 PMM2 CP CALR-1 GGCX PDHA1 KDELR1 CTR9 RTF1 SEC31A PAF1 DERL1 DPAGT1 MPI DOLK DCTN1 ST3GAL5 CGA RPL5-1 MPDU1 FUT6;FUT5;FUT3 NUS1 SLC17A5 PDIA3 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 AKT2 AKT3 HIVEP3 WWTR1 YES1 ITGBL1 SATB2 PPARGC1A MAF PPARGC1B IHH PSMD12 MSX2 PSMD11 HDAC6 PSMD14 PSMD13 PSMA7 BMP2 PSMD8 SRC RBM14 PSMB6 PSMB7 PSMD6 ESRRA PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 PSMA1 PSMC4 PSMC1 SKP1 DLX5 AKT1 UBA52 WWP1 STAT1 CUL1 CCNB1 CDK4 RPS27A UBB;UBC GLI3 GLI2 CDK1 ABL1 RBX1 ZNF521 GSK3B COL1A1 HDAC4 SOX9 UCMA HEY1 TWIST2 HEY2 NR3C1 ESR1 AR SMAD1 SMAD4 SMURF1 SMAD6 HDAC3 HES1 BAX DLX6 CCND1 CBFB RUNX1 MMP13 SP7 NKX3-2 HAND2 ITGA5 PPM1D YAP1-1 MAPK1 RB1 MAPK3 STUB1 LGALS3 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress MED1 P4HB AKT2 AKT3 CSNK2A1;CSNK2A3 MAP1LC3B2;MAP1LC3B-1 SOD3 ATOX1 CCS COX7B ABCF2-H2BE1;ABCF2 PGD PRDX3 CREBBP COX7C PRDX6 PSMD12 NOTCH1 PSMD11 COX8A PSMD14 PSMD13 COX8C PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 SRXN1 PSMB4 PSMD7 TXNIP GPX6 CAT PRKCI GPX5 COX5B PSMB5 GPX8 PSMB2 SKP2 PRDX2 GPX7 PSMB3 PSMD2 PALB2 ALB COX5A EGF PSMD3 PRDX1 PSMB1 PSMD1 ADRM1 NCOA1 NCOA2 TXNRD2 PSMC2-1 NCOA6 PSMA2-1 PSMA5 SEM1 GPX1 COX6C UBXN7 PSMA6 PSMC5 PSMA3 PDGFA PSMC6 MAFK PSMA4 AREG BTRC NFE2L2 CDKN1A PSMC3 PSMA1 DPP3 PSMC4 NCOR2 PSMC1 SKP1 BRCA1 COX6A1 COX6A2 NCOR1 TXN2 CCL13;CCL2 EIF2AK3 TXNRD1 G6PD AQP8 AKT1 COX6B2 UBA52 KEAP1 COX6B1 PRKCD ATF4 STAP2 CUL1 NOX4 PTK6 NPLOC4 AMER1 GSTP1 TRIM21 GCLC UFD1 GCLM CHD9 CYCS-1 EP300 VCP-1 RPS27A UBB;UBC TBL1XR1 SESN2 FABP1 BLVRB TXN HELZ2 BLVRA RBX1 STAT3 MAFG BCL2 BCL2L1 NLRP3 GSK3B SQSTM1 TGS1 CHD6 SP1 SIN3A RXRA CARM1 PPARA COX4I1 HBD;HBB COX4I2 HBA2;HBA1 ME1 CYBB CYBA CUL3 MYC COX7A2L-1 SMARCD3 HDAC3 CSNK2A2 PRKAA2 NQO1 HMOX1 HMOX2 CSNK2B ABCG2 IDH1 COX7A2 GSTA3;GSTA1 NCF1 NCF2 NCF4 RELA SOD2 TALDO1 SOD1 NOX5 NDUFA4 TKT ATP7A CDKN2A ERO1A FBXL17 BACH1 SESN1 NFKB1 MUL1 HM13 SLC7A11 NUDT2 ABCC3 ABCC1 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT1 TYK2 STAT2 IL19 PTPN11 STAT5A STAT3 STAT5B IL10RB IFNLR1 IL20RA IL20RB IL22RA2 IL22RA1 IFNL2;IFNL3;IFNL1 IL22 JAK1 STAT4 IL20 JAK2 IL26 IL24 JAK3 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles PSIP1 BANF1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly GEMIN4 NCBP1 GEMIN5 NUP133 GEMIN6 SNRPF SNRPD2 GEMIN7 SNRPD1 GEMIN8 NUP50 POM121;POM121C SNRPB SNRPD3 NUP54 PHAX NUP42 TGS1 NUP43 SNRPE-2 RAE1 RANBP2 CLNS1A SNUPN NCBP2-1 NUP35 DDX20 NUP37 SNRPG-2 NUP107 NUP188 WDR77 SMN2;SMN1 NUP210 PRMT5 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 GEMIN2 NUP62 NDC1 SEC13 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors GP1BA GP5 GP9 KLKB1 F9 KNG1 F12 GP1BB F11 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling IL18BP IL4 IL18RAP ALOX5 IL13 IL37 IL18 IL18R1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins ADAMTS2 ADAMTS3 ADAMTS1 ADAMTSL5 ADAMTSL4 ADAMTSL2 THSD7A ADAMTS8 ADAMTS6 ADAMTS7 ADAMTS9 SBSPON ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS19 ADAMTS17 ADAMTS13 ADAMTS16 POFUT2 ADAMTS18 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTSL3;ADAMTSL1 ADAMTS4 THBS1 ADAMTSL1 ADAMTS5 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PAK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 OPA1 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 ARHGAP10 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 OMA1 SEM1 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G4A LPCAT4 CRLS1 PLA2G1B PLA2R1 LPGAT1 LPCAT1 PLA2G3 PLA2G5 PLA2G2A-1 PLA2G10;LOC100652777 PLA2G2F PLA2G12A PLA2G4F PLA2G2D JMJD7-PLA2G4B;PLA2G4B PLA2G2E PLA2G4D RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L TBP BDP1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion ANO9 ANO6 TMPRSS2 ANO4 FURIN ANO5 ACE2 ANO2 ANO10 ANO3 ANO1 ANO8 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network FGF20 FGF23 INSR TGFA PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 IRS2 LCK SRC PIP5K1A PIP5K1B PIP5K1C EGF ERBB2 EGFR PDGFRA FGF6 HGF GAB1 PPP2R1A MET AREG RAC1 NRG1 NRG2 FGF7 EREG BTC FGF22 FGF3 FGF10 NRG3 NRG4 HBEGF KIT NTRK3 AKT1 NTF3 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG PPP2R5E VAV1 IER3 FLT3LG PDGFB CD19 CD28 STRN GAB2 PHLPP2 PHLPP1 IL33 CD86 FGF2 IRAK1 KLB CD80 PDGFRB INS;INS-IGF2 FGF19 FGFR4 IL1RL1 TRAT1 FLT3 PIK3AP1 ESR1 THEM4 PIP4K2A PIP4K2B PTEN PIP4K2C PIK3CD TRAF6 PIK3CG IRS1 PIK3R2 ESR2 PIK3CB PIK3R1 FYN FRS2 PIK3CA MYD88 PTPN11 IRAK4 EPGN NTRK2 BDNF TRIB3 MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation PTPN1 SRMS PTK6 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X GRSF1 RPL35 DNAJC3-1 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF18A KIF18B KIF12 KIF11 KIF15 KIF19 KIF13B KIF1C KIF1B KIF3A KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIF5B KIFC2 KIF5A KIFC1 KIF21A KIF21B KIFAP3 KIF2C KIF4B;KIF4A KIF2B KIF16B KIF20A KIF20B KLC1 CENPE KLC4 KIF26A KLC3 KLC2 KIF26B RACGAP1 KIF3B KIF3C NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes ATF4 TXN MAFK NFE2L2 NQO1 HMOX1 GCLC GCLM SRXN1 EP300 TXNRD1 BACH1 SOD3 PRDX1 SLC7A11 CREBBP CHD6 GSTA3;GSTA1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH1 NOTCH2 NOTCH3 NOTCH4 POGLUT1 POFUT1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 IRS4 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 IGF1R PIK3R4 THEM4 IGF2 PDPK1 IGF1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations PTGIS NR1H4 FMO1 FMO2 UGP2 ALDH1B1 FMO3 CYP26A1 N6AMT1 ADH1C;ADH1B;ADH1A TPMT UXS1 AHR AS3MT PTGES3-1 ABHD10 GSTA3;GSTA5;GSTA1;GSTA2 GSTK1 ACY3 AIP BPNT1 POMC CYP4F22 AHCY ESD CYP2C18-1 GSTM4 GSTM3 AKR1A1 CYP2J2-1 NCOA1 NCOA2 CYP2B6 CYB5R3 UGT1A1;UGT1A6 CYP8B1 GLYATL3 SULT1C2 SULT1B1-1 ACSS2 CYP46A1 TRMT112 GSTO2 GSTT2B;GSTT2 ACSS1 GSTO1 GGT1 AKR7A2 AKR7A3 MAT1A BPHL DPEP2 DPEP1 CYP21A2 CYP51A1 CYP11A1 ACSM1 ACSM5 SULT6B1 MTR-1 GGT5 ACSM4 MTRR NNMT GGT7 CHAC2 GGT6 CHAC1 GSTP1 GCLC GCLM PTGS1 GLYAT CMBL CYP27A1 SULT4A1 CYP2F1 ABHD14B POR CYP2U1 NAT1 GSTM1;GSTM2-1 ACY1;ABHD14A-ACY1 MAOB MTARC2 SLC35D1 MAOA PODXL2 TPST2 MTARC1 MGST3 SLC35D2 AADAC TPST1 MGST1 MGST2 CYP26B1 CYP27B1 PAOX MAT2B GSTT1 MAT2A HPGDS CYP2S1 CYP24A1 SULT2A1-4 CYP7B1 CYP19A1 UGDH TBXAS1 HSP90AB1 FDXR RXRA CYP1B1 CYP7A1 GGCT CYP11B1;CYP11B2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CBR3 UGT2A1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARNT FDX1 CYP2W1 GSTA4 ADH5 COMT CNDP2 ADH4 ARNT2 NQO2 ACSM2A;ACSM2B CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP4B1 ALDH3A1 GSTZ1 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GSTA3;GSTA1 EPHX1 BPNT2-1 CYP39A1 AHRR CES3 CES2 OPLAH CES1 ALDH2 CYP2R1 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 ALDH1A1 GSS AOC3 AOC1 AOC2 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 TACC3 AKT1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 YWHAZ PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NOTCH4 PSMC2-1 PSMA2-1 PSMA5 SEM1 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC STARD7 CSNK2A2 ABHD3-2 CSNK2A1;CSNK2A3 PHOSPHO1 CSNK2B CHAT CEPT1 BCHE CHKB CHKA STARD10 PEMT SLC44A5 ACHE CHPT1 SLC44A3 LPIN1 LPIN2 SLC44A4 LPIN3 SLC44A1 SLC44A2 LPCAT1 PCTP PCYT1B PCYT1A MFSD2A LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival GNG10 GNAS-1 GNG2 ADCY9 GNG5 GNG4 PRKAR1B PRKAR1A GNG8 YES1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 CD163 ADCY5 PLK2 GNG13 RHBDF2 PRKACB-1 MYH9 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 ADAM17 ITPR2 GNB5 ITPR3 CD3G CYSLTR1 CYSLTR2 GNAT3 SYK FGR HCK ADORA2B GNAI1 GNAZ PLCG1 GNAI3 GNAI2 FCGR3A;FCGR3B FYN FCGR1A PRKACA-1 PLCG2 GGT1 CALM3;CALM1 DPEP2 DPEP1 LYN IL10 GNGT1 GGT5 FURIN PRKAR2B AHCYL1 IL6 PRKX MAPK14 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta TBK1 DHX58 TKFC PCBP2 MAVS CREBBP PIN1 HSP90AB1 ITCH APP TAX1BP1 RNF125 NFKB2 IRF3 TRAF3 TRAF6 ATG12-1 IRF7 ATG5 IKBKE TOMM70 NLRX1 AGER S100A12 IFNB1-4 TNFAIP3 NFKBIB SAA2;SAA1 UBE2D3-1 NKIRAS1 NKIRAS2 CYLD TRAF2 CHUK CASP8 HSP90AA1 SIKE1 UBA7 DDX58 RIPK1 NLRC5 ISG15 UBE2L6 CASP10 HMGB1-1 FADD HERC5 MAP3K1 IFIH1 RNF135 IKBKB OTUD5 TRIM25 IKBKG UBE2D3;UBE2D2 UBA52 NFKBIA UBE2K UBE2D1 TANK RELA RNF216 EP300 RPS27A UBB;UBC NFKB1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints TPTEP2-CSNK1E;CSNK1E RBX1 MDM2-2 CCNA2-1 CCNA1 GSK3B CSNK1A1 MDM4 PSMD12 CHEK2 PSMD11 CHEK1 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 ZNF385A PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PCBP4 PSMB1 PSMD1 ADRM1 COP1 PLK3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 CDKN1A BTRC PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 FBXW11 NEK11 UBA52 CUL1 CDK2 RPS27A CDKN2A UBB;UBC CCNE2 MAPK14 CCNE1 MAPK11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade GNGT1 GNAT1 CNGB1 PDE6B PDE6A RHO GNB1 CNGA1 SLC24A1 SAG P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint MDM2-2 CCNA2-1 CCNA1 MDM4 PSMD12 CHEK2 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 ZNF385A PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PCBP4 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 UBA52 CDK2 RPS27A CDKN2A UBB;UBC CCNE2 CCNE1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 GNB3 PLA2G4A GNGT1 P2RY1 GNB5 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 MAPK14 GNG13 GNAQ GNB2 GNB1 GNB4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol CYP27A1 AMACR SLC27A2 SLC27A5 AKR1D1 CYP39A1 CYP46A1 ABCD3 HSD3B7 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy HSPA8 PLIN2 PRKAB1 PRKAB2 PRKAA2 PRKAG1 PLIN3 PRKAG3 PRKAG2 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS BCAN VCAN DCN CSPG5 CHSY1-1 NCAN BGN GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation KCNJ2 KCNJ12;KCNJ18 KCNJ3 GABRQ KCNJ4 GABRA2 GNG10 GABBR2 GABRA1 GNG2 KCNJ5 ADCY9 GNG5 GABBR1 GNG4 KCNJ6 KCNJ10 GNG8 GABRA6 GABRA5 KCNJ9 GABRA4 ADCY4 GABRA3 ADCY3 KCNJ15 KCNJ16 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNAT3 GNAI1 GNAI3 GNAI2 GNAL GNGT1 GABRB3 GABRB2 GABRB1 GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 NPTN ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) PTPN11 TBK1 TANK TICAM2 LY96 TICAM1 IRF3 OPTN-1 TRAF3 RPS27A IRF7 CD14 UBB;UBC TLR4 IKBKE UBA52 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription HDAC1 HES1 SNW1 MAMLD1 RBX1 HDAC10 NCOR2 SKP1 KAT2B CDK8 KAT2A NCOR1 HES5 HDAC11 TLE4 TLE2 TLE1 HDAC4 CCNC-1 HEY1 HEY2 CREBBP HDAC5 HDAC8 UBA52 HDAC9 NOTCH1 HDAC6 HDAC7 NBEA CUL1 RBPJ HEYL MAML2 EP300 MAML1 RPS27A UBB;UBC TBL1XR1 MAML3 HIF1A MYC HDAC2 HDAC3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes MSH2 FANCD2 CDK7 FANCI FANCC CTDP1 MNAT1 POLR2A POLR2B POLR2C MDC1 ATF2 POLR2D POLR2G POLR2I CHEK1 SSRP1 TCEA1 TP53 GTF2H2C;GTF2H2C_2;GTF2H2 JUN ATM CDK12 CDK13 ATR CCNK CCNT1 BRCA1 SUPT16H POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L FOS DDB2 RAD51D ERCC3 ERCC2 PMS2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 MLH1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 ELL ELOC-1 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors DLG3 DLG4 CALM3;CALM1 DLG1 GRIK5 GRIK3 GRIK4 NCALD GRIK1 GRIK2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 EIF2S2 EIF2S3;EIF2S3B RPS10 EIF2S1 RPS13 RPS12 RPS27L RPS15A EIF3C;EIF3CL RPS3 EIF1AY;EIF1AX EIF3M EIF3K EIF3L RPS2 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A FAU RPS25 RPS27A RPS27 RPS29 RPS20 RPS21 RPS24 RPS9 RPS23 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer PPP2R1A CTNNB1 RNF43 GSK3B WNT3A CSNK1A1 TNKS TNKS2 AMER1 PPP2CB;PPP2CA AXIN1 FZD5 PPP2R5B FZD4 PPP2R5A TCF7L2 PPP2R5D FZD6 PPP2R5C FZD8 PPP2R1B KREMEN1 APC PORCN PPP2R5E KREMEN2 CTBP2 CTBP1 DKK1 DKK2 DKK4 LRP5 LRP6 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels GNB3 KCNJ2 GNGT1 KCNJ12;KCNJ18 KCNJ3 GNB5 KCNJ4 GABBR2 GNG10 KCNJ5 GNG2 GABBR1 GNG5 KCNJ6 GNG4 KCNJ10 GNG8 KCNJ9 KCNJ15 KCNJ16 GNG13 GNB2 GNB1 GNB4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 CCNA2-1 CCNA1 CKS1B PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 CCND1 UBA52 CUL1 PTK6 CDK4 CDK2 RPS27A UBB;UBC CCNE2 CCNE1 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB38 RAB30 RAB36 RAB5B RAB6B RAB2A RAB22A RAB40C RAB3B RAB3C RAB42 RAB39A RAB2B RAB34 RAB27A PTP4A2 RAB39B RAB20 RAB27B RAB9A RAB25 RAB26 RAB23 RAB29 RAB9B RAB15 RAB19 RAB17 RAB8B RAB4A RAB33A RABGGTB RAB7B RABGGTA RAB1A RAB5A RAB1B RAB21 CHML RAB6A RAB33B-1 RAB11B RAB10 RAB13 RAB18 RAB8A CHM RAB3D RAB44 RAB7A RAB37 RAB4B RAB24 RAB14 RAB11A RAB3A RAB5C RAB32 RAB31 RAB35 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade C1S CFD C3-1 MASP1 CD19 CFB C4BPA C4BPB VTN LOC110384692;C4A;C4B_2;C4B PROS1 C1QB CPB2 CRP CD81 COLEC10 C1R C5AR2 FCN2;FCN1 CFI F2 C5AR1 C8B C8A CPN2 C2 CPN1 CR1L;CR1 C5 SERPING1 CLU C8G C6 C7 C3AR1 C9 CD59 CD55 MBL2-1 CR2 CFHR1;CFHR2 CFH-3 ELANE C1QC COLEC11 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP2S1 CYP2D6;LOC107987479;LOC107987478-1 CYP4B1 CYP4F22 CYP2U1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2W1 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EIF4A2 EIF4A1 EIF4E EIF2S2 EIF4B EIF2S3;EIF2S3B EIF2S1 RPS27L RPS15A RPS3 RPS2 FAU RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPS15 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells FOXA3 GCK FOXA2 AKT2 AKT3 SLC2A2 HNF4G FOXO1-1 INS;INS-IGF2 NEUROD1 NKX6-1 NKX2-2 PDX1 PAX6 HNF1A MAFA RFX6 AKT1 IAPP SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 FGFR3 FGF2 PLCG1 HRAS PIK3R1 FGF1 FGF4 FGF16 NRAS FGF9 FGF18 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins CCDC88C DVL1 DVL2 DVL3 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis STAG2 SMC1A ATR ACD TINF2 SYCP1 BRCA1 H2AJ SYNE2 TERF2 SYNE1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 SUN1 TERF2IP TEX12 TERF1-1 SMC1B SYCP3-2 LMNB1 SYCE2 FKBP6 SYCE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I HSPA2 H2BC15;H2BC3;H2BC11;H2BC12 REC8 H2BC5 STAG3 SYCP2-1 H2BC21 H2BC1 SUN2 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 SMC3 RAD21 H2AC14 STAG1 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity GJA1 TJP1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 PRKCZ NRAS DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 MSH2 MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNB3 GNGT1 GNB5 GNG10 GNG2 GNG5 GNG4 PLCB3 GNG8 PLCB1 PLCB2 GNG13 GNB2 GNB1 GNB4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding TAS2R3-1 S1PR1 TAS2R16 DRD1 CCL3L1;CCL3L3;CCL3;CCL18 DRD2 DRD3 DRD4 DRD5 POMC TAS2R40 TAS2R41 APP TAS2R39 ADORA2A ADORA3 ADORA1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 WNT3A PRH1-TAS2R14;TAS2R14-3 LHB TAS2R7 TAS2R8 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 TAS2R1 TAS2R4 C3AR1 TAS1R2 TAS1R1 TAS1R3 GNGT1 GLP1R SST GNG10 RAMP2 GABBR2 GNG2 GABBR1 GNG5 GNG4 GNG8 GNG13 IHH GNB2 GNB1 ADM IAPP GNB4 CHRM2 GNB3 CHRM4 ADRB1 ADRB2 GNB5 HTR4 HTR6 HTR7 HRH3 HRH2 CALCRL HRH4 HTR1E TAAR8 TAAR9 MCHR1 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 SCT RXFP4 MRGPRD FZD10 RXFP1 RXFP2 RXFP3 CRHBP CMKLR1 AGTR2 FPR1 SSTR3 GHRHR GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10B WNT10A FZD9 GPR183 PNOC MC4R GPR18 EDNRB RHO PTH1R EDN1 UCN3 EDN3 GPR37 GPR35 PTH2R RGR MC3R PLPPR1 PLPPR2 PLPPR3 MC1R PLPPR4 MC5R PLPPR5 WNT8A WNT8B NPFFR2 NPFFR1 P2RY12 NPFF HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR WNT7B QRFP GPR55 HCRTR2 SCTR HCRTR1 WNT7A ADM2 MTNR1A MTNR1B CALCB;CALCA RLN3 ECE1 PRLHR INSL3 INSL5 P2RY4 ADCYAP1 APLN ECE2;EEF1AKMT4-ECE2 ADCYAP1R1 VIPR1 VIPR2 RRH PTGDR GPR37L1 KEL TAS2R42 ADRA2B GIPR CRHR1 NLN PENK PPY CRH PTGDR2 NPY4R2;NPY4R OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB RAMP3 PTH PTGER2 PTGER3 NPW RLN2;RLN1 PRLH MAS1 XK GHRH HCAR1 HCAR2;HCAR3 RAMP1 NPY2R NPY NPY1R APLNR SUCNR1 WNT6 CALCR WNT2 WNT3 OPN3 OXTR PTCH2 GRPR OPN5 EDNRA PYY PROK2 PROK1 UTS2R WNT2B ADGRE1 TRHR GRM3 OPRM1 UTS2B HEBP1 AGTR1 GRM2 PTGFR ADGRE5 LPAR1 GRM7 LPAR2 GRM6 CXCL12 LPAR3 GPER1 FPR2 ADGRE3 LPAR4 GRM8 NTSR1 NTSR2 GPR17 PTGIR NMB NPY5R XCR1 OPRK1 XCL1;XCL2 GLP2R NMBR SSTR1 LPAR5 SSTR2 LPAR6 WNT16 NMS SSTR4 NMU SSTR5 GNRH1 MLN OPRL1 BRS3 PTHLH GPRC6A CNR2 GPR132 CNR1 CCKAR GNRHR S1PR3 FFAR4 FFAR2 S1PR2 S1PR5 GPR39 S1PR4 EDN2 ANXA1 TACR2 TACR3 ACKR1 TACR1 VIP CCKBR NPSR1 GRP F2R PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 CHRM1 CCR2 GPR68 GPR65 CHRM5 PMCH GHSR CASR LTB4R2 NTS MCHR2 HRH1 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 CALCA P2RY6 P2RY2 P2RY1 CCK KISS1 FFAR3;GPR42 GIP GCGR C5AR2 C5AR1 C5 CD55 GNAS-1 SMO ADRA1D PTCH1 ADRA1B ADRA1A TBXA2R FSHB SHH CYSLTR1 CYSLTR2 ADORA2B OPN1SW C3-1 SAA2;SAA1 MC2R CCR5 WNT9A AGT CHRM3 AVPR2 CXCR4 WNT5A WNT1 FZD1 FZD3 FZD2 FZD5 FZD4 FZD7 PSAP FZD6 FZD8 GCG CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 CCR8 CCR7 CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 DHH CCL17 CCR10 CCL16 CCR1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 LHCGR FSHR GPHA2 TSHR GPHB5 WNT11 WNT4 WNT9B PDYN FFAR1 CENPS-CORT;CORT;CENPS CGA CX3CR1 AVPR1B AVPR1A AVP TSHB HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis SLC35D2 EXT1 EXT2 NDST2 NDST1 NDST4 NDST3 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 HS3ST5 HSPG2 GPC6 HS3ST6 HS3ST4 HS3ST1 HS3ST2 HS6ST1 HS3ST3A1 HS6ST2 HS6ST3 EXTL2 AGRN SDC1 HS2ST1 HS3ST3B1 EXTL3 GLCE INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation CDK1 PPP2R1A LBR CCNB2 EMD CCNB1 PPP2CB;PPP2CA SIRT2 LEMD3 BANF1 ANKLE2 KPNB1 LMNB1 VRK1 LEMD2 PPP2R2A;PPP2R2D WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking WNT9A WNT16 VPS29 VPS35 WNT10B WNT10A WNT11 WLS WNT3A VPS26A WNT4 SNX3 TMED5 WNT5B WNT9B WNT5A WNT1 WNT8A WNT8B WNT6 WNT2 WNT7B WNT3 PORCN WNT7A WNT2B ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS SOS1 NTF3 HRAS NTRK3 NRAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection ABL1 ARPC4 ARPC5 WAS ARPC2 ARPC3 YES1 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A WASL ACTG1 CD3G CDC42 SYK FGR HCK FCGR3A;FCGR3B FYN WASF2 WASF3 BAIAP2 NCKIPSD RAC1 MYO10 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK DOCK1 LYN PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b MPI ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis ITPR1 PRKCD ITPR2 PIK3CA ITPR3 PRKCE PLPP5 PLPP4 PLCG2 CD3G AHCYL1 SYK PIK3R2 PIK3CB PLCG1 PLD4 PIK3R1 FCGR3A;FCGR3B FCGR1A PLD1 PLA2G6 PLD3 PLD2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins PROC F2 F7 GGCX FURIN F9 PROS1 F10 GAS6 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones DDC TPO DUOX1 CGA DUOXA1 DUOXA2 DBH AANAT TXNDC11 DUOX2 PNMT IYD DIO1 CAV1 DIO3 SLC5A5 TSHB TH TPH2 TPH1 ASMT NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases JUN GOLGA2 CDK5R1 CDC25A CDC25B BCL2L11 APP SOD2 FASLG FOXO3 CDK5 PRDX2 CAPNS1 CAPNS2 PRDX1 LMNB1 YWHAE CAPN2 CAPN1 CAST CDC25C SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 FGF20 SOS1 FGF23 FGF2 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FGF4 NRAS FGF9 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis HOXC4 HOXA2 PBX1 PAXIP1 CNOT6 YY1 DPY30 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B PAGR1 POLR2C PAX6 CREBBP POLR2D CTCF H2BC21 POLR2G POLR2I CNOT9 WDR5 RXRA KDM6A H2AC20 EED RARA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EZH2 HOXB4 ASH2L NCOA6 NCOA3 HDAC3 JUN RARG RBBP4 RBBP5 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 POLR2E RARB POLR2F POLR2H RBBP7 HOXA3 POLR2L HOXA1 PKNOX1 HOXA4 PIAS2 HOXB3 H2BC15;H2BC3;H2BC11;H2BC12 HOXB2 SUZ12 HOXB1 H2BC5 AJUBA HOXD1 PCGF2 MEIS1 H2BC1 MAFB HOXD4 HOXD3 ZNF335 POLR2J;POLR2J2;POLR2J3 EP300 EGR2 H2AC4 KMT2D KMT2C H2AC14 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing OGG1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling SOS1 PIK3CA PTPN6 PIK3R3 IL3RA IL2RB GAB2 INPPL1 CSF2RB CSF2RA INPP5D IL5RA SHC1-1 JAK2 CSF2 IL2 IL3 PIK3CD PIK3R2 PIK3CB IL5 IL2RA PIK3R1 IL2RG JAK1 JAK3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript CPSF1 NCBP1 NUP133 CPSF3 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E SYMPK NUP210 NUP93 FIP1L1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 CPSF2-1 NUP35 NUP62 NUP37 WDR33 NDC1 CPSF4 SEC13 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions HSPG2 LAMA5 ITGA1 ITGA3 LAMA3 ITGB1 ITGA7 LAMA2 ITGA6 LAMA4 ITGA2 NID1 LAMB3 LAMB2 ITGB4 ITGAV LAMB1 LAMA1 NID2 COL18A1 LAMC3 LAMC2 LAMC1 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260910%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism BCKDHA ACAD8 MCCC2 ECHS1 HIBADH MCCC1 BCKDHB HSD17B10 ACADSB ACSF3 ACAT1 ALDH6A1 PCCA AUH IVD PCCB DBT MMUT MLYCD BCAT1 HMGCLL1 DLD HIBCH BCAT2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260910%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 FOSL1 CCND1 MYC NRIP1 ERBB2 PGR VIM TIMP1 STAT5A EGF FN1 ESR1 AREG OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260910%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS BMP4 BMP2 MAG IL1B PLP1 CNTF CNP PDGFB ASCL1 FGF2 TNF GLI2 SHH SOX8 MBP SOX9 SOX6 SOX5 NKX2-2 NKX2-6 MOG OMG LIF CXCL2;CXCL3;CXCL1-1 OLIG1 IGF1 OLIG2 MYT1 SOX10 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260910%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT LMNA ZMPSTE24 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260910%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis FADD TICAM1 TNFRSF1A MAPK8 FTL-1 CASP8 RIPK3 PARP1 TRADD TNF PLA2G4A RIPK1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260910%WP100%HOMO SAPIENS Glutathione metabolism GSTA3;GSTA5;GSTA1;GSTA2 GCLM GGT1 GGT5 G6PD GPX1 GPX4 IDH1 GSS GSR GSTT2B;GSTT2 OPLAH GSTM1;GSTM2-1 GSTA3;GSTA1 GCLC ANPEP WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260910%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis CCND1 FZD1 NEUROD1 FZD3 WNT3A WNT5A WNT7A PROX1 NEUROG2 WNT3 LRP6 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260910%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT2 AKT3 AKT1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260910%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 ACE AGTR1 AGTR2 IL6 SIGNALING%WIKIPATHWAYS_20260910%WP364%HOMO SAPIENS IL6 signaling JAK2 IL6R MAP3K7 JUNB MAPK3 JAK1 NCOA1 MAP2K4 CREBBP STAT1 BAD PRKCD STAT3 GAB1 PTPN11 TYK2 AGT VAV1 NR2F6 HCK IL6 RPS6KB1 IRF1 GRB2 VIP IL6ST SOS1 BCL2L1 SHC1-1 TIMP1 AKT1 CRP GSK3B HDAC1 PIK3R2 PIK3R1 PRDM1 NLK SOCS3 MAP2K2;MAP2K1 MAPK1 RAC1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260910%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL18 TMPRSS2 FURIN IL2 IL1B GFAP IL4 IL1A IFNG HMGB1-1 TLR8 IL12A TLR7 TLR4 TNF TLR3 ACE2 IL6 IL10 CCL11 MAPK1 CXCL8 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases DLL1 DLL3 DLL4 MAPK9 WNT11 MAPK7 HES3 MAPK6 HES2 MAPK4 WNT7B MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 CTNNB1 FGF2 GLI2 SOX9 BMP4 BMP2 MAPK8 FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 PIK3R2 PIK3R1 MAPK1 MAPK3 STAT1 PRKCD IHH FZD10 RBPJ FGF1 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PRKCG HES6 PRKCI PRKCH WNT5B PRKCB PRKCE PRKCA RUNX2 SMO PRKCQ PRKD1 NOTCH2 NOTCH3 NOTCH1 PRKDC NOTCH4 PIK3R4 PIK3R3 PRKCZ PIK3R6 PIK3R5 WNT6 WNT1 WNT2 WNT4 JAG2 WNT10B SMAD1 WNT10A SMAD4 FZD2 JAG1 FZD5 FZD4 FZD7 PTCH1 FZD6 FZD9 SMAD9 FZD8 SMAD5 FGF18 FGFR4 BMPR1B FGFR3 FGFR2 BMPR1A FGF10 FGFR1 WNT2B BMPR2 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG GLI3 PIK3C2B HEY1 HEY2 WNT9B WNT9A WNT16 PIK3CA MYOD1 PPARG PIK3C3 LRP5 WNT8A WNT8B MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response RB1 CDKN1A CDKN1B MRE11 HUS1B BRCA1 BBC3 CASP9 PIDD1 CCND3 CCND2 CHEK2 CASP3 SESN1 CHEK1 TLK2 CCND1 TLK1 MYC NBN APAF1 RFC1 SMC1A CDC25C CDC25A DDB2 CREB1 CCNE2 RRM2B FANCD2 CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 MDM2-2 CYCS-1 CCNB3 CCNB2 CCNB1 ABL1 E2F1 PMAIP1 SFN BID ATRIP GADD45B GADD45A RPA2 PML GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 CCNG1 PRKDC CDK1 RAD17 CASP8 FAS BAX RAD1 ATM ATR RAD9A FOXA2 PATHWAY%WIKIPATHWAYS_20260910%WP5066%HOMO SAPIENS FOXA2 pathway GSTA3;GSTA5;GSTA1;GSTA2 FOXA2 ABCC3 FOXA1 SREBF1 ABCC4 ABCC2 IRS1 MTTP IRS2 FOXO1-1 ACACA INS;INS-IGF2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 GSTM1;GSTM2-1 FASN GSTA3;GSTA1 APOB SLC27A5 PPARGC1B 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome MTMR10 KLF13 OTUD7A CHRNA7;CHRFAM7A GPR75 TRPM1 KAT2B CREBBP GRM6 CCL5 SERPINH1 FYN FANCD2 FAN1 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260910%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment CXCL10 TRAF6 IL2RA IL2RB PDCD1 STAT3 IL4 CCL5 TLR8 TLR7 TLR4 CD86 CD274 CCL13;CCL2 CD80 IL2RG SOCS1 CTLA4 STAT6 PIAS3 TGFB2 IL4R TGFB1 TGFB3 IRAK4 NFKB1 NFKB2 TGFBR2 LUNG FIBROSIS%WIKIPATHWAYS_20260910%WP3624%HOMO SAPIENS Lung fibrosis CSF3 CSF2 SERPINA1 FAM13A MECP2 MT2A CYSLTR2 PLAU IL12B CCN2 CCR3 CCR2 DSP EDN1 HGF ELMOD2 IL6 SFTPC MMP2 IL13 ATP11A MMP9 GREM1 CCL3L1;CCL3L3;CCL3;CCL18 CALCA EGF CEBPB RTEL1 CCL11 CXCL8 PARN PDGFA TGFA CCL4L2;CCL4L1;CCL4 TERT DPP9 SPP1 IL4 HMOX1 TIMP1 SKIL STN1 CMA1 PDGFB MUC5B BMP7 FGF2 SMAD7 TNF IL5 PTX3 NFE2L2 FGF1 FGF7 CXCL2;CXCL3;CXCL1-1 IGF1 IL1B CCL5 CCL13;CCL2 TGFB1 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260910%WP5088%HOMO SAPIENS Prostaglandin signaling CXCL10 IL1B CCR2 IL6 MMP9 CCL3L1;CCL3L3;CCL3;CCL18 CXCL8 AREG IL1A IFNG IL12A TNF PTGER4 CCL13;CCL2 CXCL9 PIK3CG CSF1 PTGER2 AHR PYCARD CASP1 NLRP3 VEGFA IRF7 TGFB1 CXCL2;CXCL3;CXCL1-1 CD28 IL17F KLRD1 NFKB1 PTGES IL17A PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260910%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER3 ALOX15 ADCY3 ALOX12 LTC4S GNAI1 PTGS1 CYSLTR1 NRAS ALOX5 LTA4H PTGDS HRAS PTGIS IGFBP5 PLA2G4A ALOX15B MAPK11 SIRT1 RB1 GNAS-1 CDKN1A GNAQ PRXL2B ALOX5AP TBXAS1 KRAS PTGS2-2 TP53 PTGER4 PTGER2 PTGES PTGER1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260910%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein WDR19 IFT122 IFT80 WDR35 HSPB11 DYNC2LI1 DYNC1LI1 DYNC1LI2 IFT22 IFT43 IFT81 IFT27 DYNLRB2 DYNLRB1 IFT46 DYNC1I1 DYNC2H1 DYNC2I2 DYNC1H1 DYNC1I2 DYNC2I1 DYNLT1 IFT140 DYNLT2B NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260910%WP5572%HOMO SAPIENS Nucleosome remodeling complex H4C6 ASF1A MCM2 ASF1B PRKDC NASP-1 SUPT16H XRCC6 DAXX PCNA XRCC5 H4-16 NAP1L1 SSRP1 IPO4 CHAF1B CHAF1A RBBP4 CHEK2 HAT1 SMIM40 H4C1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5049%HOMO SAPIENS Glycolysis in senescence RB1 LDHA G6PD GAPDH-1 PRKAA1 PKM PGK1 ALDOC ENO1 HK1 TP53 IL4 SIGNALING%WIKIPATHWAYS_20260910%WP395%HOMO SAPIENS IL4 signaling JAK2 MAPK3 JAK1 STAT1 BAD MAPK14 ATF2 STAT3 ELK1 IKBKB PTPN11 EP300 TYK2 MAPK11 JAK3 CHUK GAB2 FOS DOK2 CEBPA RPS6KB1 CBL RELA GRB2 INPP5D FLNA SOS1 SOCS5 STAT5A STAT5B NFKBIA SHC1-1 CEBPB FES PTPN6 IL4 IRS1 IRS2 PIK3CD AKT1 IL2RG SOCS1 STAT6 PIK3R2 IL4R PIK3CA PIK3R1 SOCS3 NFKB1 MAPK1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260910%WP5236%HOMO SAPIENS Markers of kidney cell lineage CITED1 EPO TNC SIX1 TCF21 SALL1 HNF4A SIX2 KDR RSPO3 RSPO1 DACT1 PDGFRB BMP7 EMX2 FOXD1 OSR1 KCTD1 HNF1B HNF1A AXIN2 DCN PAX2 ACTA2 FGF7 SFRP1 FGF8 ALDH1A2 KIT PECAM1 TSHZ3 NTN1 NT5E EGLN1 EGLN3 EGLN2 EYA1 BMP4 AP2B1 TBX18 PBX1 DES NOTCH2 NPHS1 GDNF NOTCH1 NPHS2 WT1 LHX1 TLX1 REN FAT4 VSX2 WNT4 SMAD1 JAG1 SMAD5 WNT5A LIDOCAINE METABOLISM%WIKIPATHWAYS_20260910%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260910%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAPK9 JUNB MAPK3 MAP2K4 MAPK8 MAPK14 ATF2 MAPK12 MAPK13 MAPK10 MAPK11 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K9 FOS MAP2K7 EIF4E MAP3K4 MAP2K6 MAP2K3 JUN MAP3K1 BST2 DDIT3 BCL2 IFITM3;IFITM2;IFITM1 MAP3K10 RAF1 MAP3K11 MAP2K2;MAP2K1 MAPK1 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260910%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GPX4 GSS GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 TPMT CYP46A1 COMT HNMT HS6ST1 HS6ST2 HS6ST3 NAA80 NDST2 NDST1 AKR7A2 AKR7A3 NDST4 NDST3 CYP1B1 GSTK1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP39A1 SULT2B1 CYP27A1 CYP2U1 CYP2E1 SULT6B1 SULT2A1-4 NNMT HS3ST3A1 GSTCD MGST3 MGST1 MGST2 GLYAT CYP4F22 CYP19A1 CYP27B1 CYP4X1 CYP2B6 CHST11 CHST12 CYP11A1 CHST10 CHST13 CHST14 GSTM4 GSTM3 EPHX2 EPHX1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP26A1 CYP27C1 CYP2S1 CYP1A1 NAT9 GAL3ST1 NAT10 AKR1B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 NAT14 HS2ST1 SULT1C3 SULT1C2 CYP26B1 AKR1B15;AKR1B10 CYP4V2 CYP2R1 UGT2A1 SULT4A1 GAL3ST3 GAL3ST4 HS3ST3B1 CHST8 CHST9 CYP2D6;LOC107987479;LOC107987478-1 CHST6 NAA30 CHST7 GSTO2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 GSTO1 GPX5 AKR1A1 KCNAB1 KCNAB2 CYP7B1 KCNAB3 BAAT INMT NAA40-2 CYP21A2 CHST1 CHST4 NAT8L CHST2 CHST3 CYP2J2-1 NAA20 GSTP1 AKR1D1 CYP2C18-1 CYP7A1 CYP17A1 NAA50-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2F1 CYP51A1 NAT8-2 FMO1 CYP4B1 FMO2 HS3ST5 HS3ST6 FMO3 FMO4 HS3ST4 CYP8B1 FMO5 HS3ST1 SULT1B1-1 HS3ST2 GSTZ1 CYP2W1 CYP24A1 GSTA4 CYP11B1;CYP11B2 CYP20A1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260910%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB3 ITGB2 ILK ITGAE ITGAL MYPN MAPK7 ITGAX RAC3 MAPK6 ITGB8 ITGAV MAPK4 ITGB7 ITGB6 VAV3 MAPK12 ITGA4 PDPK1 MAPK10 ITGA3 ITGA2 ITGA1 VAV2 ITGAD ITGA8 RAPGEF1 ITGA7 ITGA6 ITGA5 ARHGEF7 CRK DOCK1 ITGA9 ROCK1 ROCK2 SRC CDC42 PAK1 RHO CSK PAK3 PAK2 PAK4 GIT2 SORBS1 CAPN11 CAPN10 ZYX BCAR1 MAP2K6 MAP2K3 RAF1 FYN AKT2 AKT3 AKT1 PIK3R2 MAP2K2;MAP2K1 MAPK1 RAC1 GRB2 SOS1 SHC1-1 HRAS MYLK2 BUB1B-PAK6;PAK6 ITGA2B ARAF CAPN9 CAPNS1 CAPN6 CAPN7 CAPN5 CAPN2 CAPN3 CAPN1 TNS1 SELENOP TLN1 VCL SHC3 PXN RAP1B RAP1A MAP2K5 VASP CAV3 CAV2 CAV1 BRAF PTK2 ITGA10 ITGA11 ITGB1 ITGAM ITGB5 ITGB4 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260910%WP530%HOMO SAPIENS Cytokines and inflammatory response IL1B CSF3 CSF2 IL12B IL6 IL13 IL10 PDGFA IL2 IL4 IL1A IFNG TNF IL11 IL5 IFNB1-4 IL15 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IL3 CSF1 CD4 IL7 HLA-DRA TGFB1 CXCL2;CXCL3;CXCL1-1 FELBAMATE METABOLISM%WIKIPATHWAYS_20260910%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260910%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IDO1 IL1B IFNG TNF IFNB1-4 AHR IL6 DDC GOT2-1 AADAT HAAO KMO TDO2 KYNU AFMID KYAT3 KYAT1 IDO2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260910%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming FTO ANKRD13C DNMT1 HDAC2 GGT6 CADM1 YTHDF3 CREBBP DNMT3A TET2 NOL9 PIP4K2A EZH2 EP300 IRS1 HDAC1 IFITM3;IFITM2;IFITM1 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260910%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders H4C6 WWTR1 YES1 SRRT SOX11 SOX12 POU3F1 POU3F2 FGF4 UTF1 SOX2 H4-16 SOX15 ZSCAN10 TEAD2 SOX4 H4C1 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260910%WP727%HOMO SAPIENS Monoamine transport and regulation ITGB3 IL1B MAPK14 AGT ACHE TPH2 TGFB1I1 PPP2CB;PPP2CA TNFRSF11B DBH SLC6A1 SLC6A2 SLC6A3 SLC6A4 HRH3 NOS1 UNC13B CDC25C IL1R1 TSC2 FBXO32 SYN1 SCAMP2 RBL2 TNF SLC5A7 ADORA2A TH AMPH STX1A NECTIN2 TDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260910%WP2037%HOMO SAPIENS Prolactin signaling JAK2 SOCS2 EIF4EBP1 PTPN1 MAPK9 TEC MAPK3 NFKBIB JAK1 STAT1 MAPK14 STAT3 ELK1 PTPN11 VAV1 GAB2 VAV2 FOS RPS6KB1 CBL RELA GRB2 FLNA SOS1 STAT5A STAT5B NFKBIA SHC1-1 CASP3 PTPN6 SRC PAK1 MYC ERBB2 MAPK8 HRAS RPS6KA2 IRS1 IRS2 JUN RAF1 FYN PIK3CB AKT1 PXN MTOR PIK3CG PRL NEK3 SOCS1 CTSD GSK3B YWHAG PIAS3 CISH RPS6 PIK3R2 PRLR PIK3CA PIK3R1 PTK2 YWHAZ ZAP70 ITGB1 PPIB SOCS3 PPIA MAP2K2;MAP2K1 NFKB1 AGAP2 MAPK1 RAC1 SIRPA;SIRPB1;SIRPG VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260910%WP1533%HOMO SAPIENS Vitamin B12 metabolism SCARB1 SERPINA3 MTRR SERPINE1 PLAT MTR-1 MPO ICAM1 MCEE SAA2;SAA1 CBS;CBSL FGB FGA CUBN SAA2-SAA4;SAA4 MMUT FGG IL6 APOA1 MAT1A F2 RELA F7 SHMT2 PLG LRP2 HBD;HBB APOE LDLR ABCA1 CBLIF MMAB INSR MTHFR SOD2 SOD3 SOD1 IFNG HBA2;HBA1 TCN2 TCN1 CTH ALB TNF IL1B INS;INS-IGF2 APOB CCL5 CCL13;CCL2 CRP NFKB1 NFKB2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260910%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis EGR2 CEBPD CEBPG GATA3 GATA2 KLF15 SREBF1 KLF2 KLF5 CEBPA PPARG DDIT3 CEBPB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260910%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IDO1 NOS1 IFNG TLR4 TNF IFNB1-4 TP53 CDKN1A KLF5 IL1R2 AHR EIF2AK1 QPRT AADAT EIF2AK4 HAAO FOXO1-1 ACMSD KMO CAT TDO2 KYNU AFMID IDO2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260910%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP2A13;CYP2A6;CYP2A7-1 XDH CYP1A2 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA MECR OXSM HSD17B12 MCAT METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260910%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts SLC2A1 LPAR1 PLOD1 SLC1A5 LOXL2 LDHA GLS ADAMTS2 UGP2 PHGDH PLCG1 CD36 PGM1 PSPH SLC16A1 PYCR1 P3H4 P3H3 RHOA GCK GLUD1;GLUD2 UGDH BMP1 P4HA1 P4HA2 PSAT1 P4HA3 ALDH18A1 FGFR4 SERPINH1 FGFR1 GPI THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260910%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ITGB3 PFKFB2 KDM3B NPR1 UCP1 ITPR2 ADCY8 SLC5A5 TPO RXRA ITGAV NPY PRDM16 BAD MAP4K5 MAPK14 ATF2 PPARGC1A DUOX2 FGF21 SLC16A10 MAFA CTNNB1 TSHR POMC TG RHEB RPS6KB1 AGRP SLC26A4 GRB2 PNPLA2 CASP9 SOS1 SRC SHH TP53 MDM2-2 ADCY3 NOTCH1 HRAS WNT4 FOXO1-1 KLB THRB THRA KDM1A TRH TTF2 RAF1 TTF1 MC4R RPTOR NPPB PRKACA-1 RPS6KA6 NHSL1 IYD TSC2 DUOXA2 MLST8 FGFR1 PRKG2 SLC16A2 TSHB AKT3 ACTL6B SECISBP2L DIO1 MTOR DIO3 TSC1 FRS2 SIRT6 LOC100509620;LOC112267859;AQP7 GSK3B SLCO1C1 CREB3 RPS6 TBC1D4 MAPKAPK3 PIK3CA ADRB3 PAX8 PPARG AKT1S1 ZNF516 MAP2K2;MAP2K1 PLIN1 MAPK1 MGLL LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260910%WP3965%HOMO SAPIENS Lipid metabolism pathway BCKDHA PRKAA1 PNPLA2 PRKAA2 ACSS2 ACACA PRKAG1 PRKAG2 ABHD5 FASN PRKAG3 PRKACB-1 LIPE PRKAR2B PRKAR2A PRKAB2 PDHA1 PRKAB1 PRKACA-1 ACLY PRKAR1B PRKAR1A ACSBG1 AKT2 AKT3 AKT1 PLIN1 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260910%WP2267%HOMO SAPIENS Synaptic vesicle pathway SNAP25 RAB3A CLTC CLTA AP2A1 PARK7 AP2A2 RIMS1 DNM1L SLC18A1 SLC18A2 AP2M1 SLC18A3 NSF UNC13C SLC38A1 UNC13A SLC32A1 SYP SYN3 SYN2 DNM1 DNM2 DNM3 SLC25A4 AP2B1 VAMP2 NAPA SLC22A3 STXBP1 CACNA1B SLC1A3 CACNA1A ATP1A2 CLN8 CPLX2 CPLX1 CPLX3 CLTCL1 AP2S1 SLC17A6 SLC17A7 SLC17A8 STX3 STX2 SYT1 SLC6A4 UNC13B SYN1 STX1A TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260910%WP3945%HOMO SAPIENS TYROBP causal network in microglia C3-1 ITGB2 GAPT C1QC ITGAX STAT5A IL18 GAL3ST4 SPP1 CD4 PYCARD SLC1A5 RPS6KA1 ABCC4 GPX1 CD84 NRROS FKBP15 NCF2 PLEK LOXL3 TGFBR1-1 TCIRG1 LYL1 RGS1 CREB3L2 CD37 IL13RA1 RNASE6 LGALS9C;LGALS9;LGALS9B TNFRSF1B RUNX3 APBB1IP SLC7A7 MAF TYROBP BIN2 ELF4 NPC2 DPYD HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 CAPG SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 ITGAM IL10RA PPP1R18;LOC107987457 LHFPL2 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260910%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development RUNX2 DMP1 KLF4 NOTCH2 DKK1 NOTCH3 DSPP NOTCH1 ALPL SP7 NOTCH4 SOST BMP7 CTNNB1 HNF1A CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 NSDHL SC5D DHCR24 DHCR7 LBR QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260910%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis NOS1 CYP2A13;CYP2A6;CYP2A7-1 IKBKB NFE2L2 MMP1 KEAP1 ACOX2 FOS MAFG MAFK PTGS2-2 VEGFA JUN NFKBIA NFKB1 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260910%WP4262%HOMO SAPIENS Breast cancer pathway DLL1 DLL3 DLL4 WNT11 WNT7B FGF21 CTNNB1 RB1 CDKN1A FOS MRE11 BRCA1 EGF ESR1 CCND1 MYC NBN ERBB2 PGR DDB2 FGF2 TP53 AXIN2 E2F1 KIT GADD45B GADD45A IGF1 GADD45G RAD50 CDK6 RAD51 CDK4 BAX PARP1 ATM ATR JUN RAF1 FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 AKT2 AKT3 AKT1 MTOR GSK3B PIK3R2 PIK3R1 MAP2K2;MAP2K1 NFKB2 MAPK1 MAPK3 NCOA1 IGF1R RPS6KB1 FRAT2 TNFSF11 GRB2 SKP1 CSNK2A2 SFRP4 SOS1 CSNK2B SHC4 SHC1-1 SHC2 TCF7 DVL1 DVL2 FGF20 DVL3 FGF23 FGF22 ESR2 FGF17 FGF16 SP1 FGF19 FLT4 CETN3 PTEN BRCA2 POLK FZD10 APC2 NCOA3 FGF1 AXIN1 FGF3 CSNK2A1;CSNK2A3 FGF4 SOS2 FGF5 LEF1 FGF6 EGFR FGF7 E2F2 FGF8 HES1 FGF9 E2F3 BAK1 HES5 TCF7L2 TCF7L1 WNT5B CSNK1A1 HEYL APC RPS6KB2 NOTCH2 NOTCH3 NOTCH1 NRAS NOTCH4 PIK3R3 HRAS WNT6 WNT1 WNT2 WNT4 JAG2 WNT10B WNT10A KRAS FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 ARAF FGF18 FGF10 FGFR1 WNT2B PIK3CD SHC3 HEY1 HEY2 BRAF WNT16 PIK3CA LRP5 ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP241%HOMO SAPIENS One carbon metabolism ST20-MTHFS;MTHFS ALDH1L1 DNMT1 MTFMT AHCYL2 AHCY SHMT1 MTRR GLRX MAT2B DNMT3A TYMS MTR-1 FTCD ATIC MTHFD1L DNMT3B AMT DHFR2;DHFR BHMT FOLH1B;FOLH1 MTHFD1 MTHFD2 CHDH GART MAT1A SHMT2 MTHFR TCN2 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260910%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling STAT1 STAT3 IL6 IL21 IL22 IL13 IL23R RORC JUN RORA NOD2 HLA-DMA IL18RAP IL10 TBX21 STAT4 SMAD2;SMAD3 IL18 IL21R IL12RB1 IL12RB2 IL2 IFNGR1 NFATC1 IL4 FOXP3 IL1A IFNG IL23A TLR5 MAF TLR2 IL12A TLR4 TNF IL5 GATA3 IL2RG STAT6 IL4R TGFB1 IL17F NFKB1 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260910%WP710%HOMO SAPIENS DNA damage response only ATM dependent MAPK9 WNT11 RAC3 WNT7B MAPK10 CTNNB1 CDKN1A CDKN1B BBC3 CCND3 CCND2 FOSL1 CDC42 CCND1 MYC ERBB2 TP53 MDM2-2 ABL1 PMAIP1 MAPK8 BAX ATM IRS1 MAP3K4 JUN MAP3K1 BCL2 WNT3A WNT5A WNT7A WNT3 RBL2 AKT2 AKT3 AKT1 GSK3B PIK3R2 PIK3R1 TGFB1 NFKB1 NFKB2 MAPK1 RAC1 MAP3K7 BAD PLAU GRB2 SOS1 SHC1-1 TCF7 LDLR DVL1 DVL2 DVL3 INSR HMGB1-1 PTEN AXIN1 SOS2 LEF1 CAT BAK1 TCF7L2 TCF7L1 WNT5B APC NRAS PIK3R4 PIK3R3 HRAS PIK3R5 WNT6 WNT1 WNT2 RHOA WNT4 WNT10B WNT10A KRAS SMAD4 SMAD2;SMAD3 SCP2 PDK1 WNT2B FOXO3 BCL2L11 PIK3CD PCK2 PIK3C2G MLKL PIK3CB G6PC1 PIK3C2A BCL6 PIK3CG TP73 FASLG PIK3C2B PPP2R5E PPP2R5C BIK CDKN2A WNT16 CCNG2 PIK3CA PIK3C3 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260910%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation MAPK3 CDK4 CDK2 IGF1R KRAS FOXO1-1 INS;INS-IGF2 TGFBR1-1 PDGFA MYC INSR SMAD7 AKT2 AKT3 AKT1 BRAF CRTC2 FLT1 FOXM1 RASSF1 IGF1 PDX1 MAPK1 PGF DLK1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260910%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGFR HPGD PTGDR2 EHHADH-1 PLA2G5 PLA2G6 PTGS1 TBXA2R JMJD7-PLA2G4B;PLA2G4B PTGR1-1 PTGDR PTGIR PTGDS ACAA1-1 PTGR2 PTGIS ACOX1 PLA2G4A ACOX3 PPARD CYP4F3;CYP4F2;CYP4F12;CYP4F11 ACOX2 PRXL2B TBXAS1 PTGS2-2 AKR1B1 PPARG PTGES MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260910%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCC1 UQCR11 UQCR10 BCS1L TTC19 UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCRC2 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260910%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 MYC E2F3 PIK3R1 TP53 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260910%WP4236%HOMO SAPIENS Krebs cycle disorders DLST GPT DHTKD1 LDHB LDHA;LDHC LDHA SUCLA2 MPC1 SUCLG2 SUCLG1 PCK2 PDHX FH MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260910%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COMP COL9A1 MATN1 COL9A3 COL9A2 MATN3 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260910%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways MRE11 BRCA1 CHEK1 NBN RFC1 DDB2 FANCD2 DCLRE1C CCNH MPG FAAP100 LIG1 REV1 LIG4 LIG3 RBX1 MSH6 NEIL3 NEIL2 MSH2 MSH3 CENPS-CORT;CORT;CENPS RPA2 XPA XPC BRIP1 RAD52 NTHL1 RAD50 NHEJ1 FANCI RAD51 FANCM XRCC4 FANCL FANCA XRCC1 FANCC FANCE PALB2 FANCG PARP1 FANCF ATM CDK7 ATR MNAT1 FEN1 WDR48 OGG1 CETN2 POLB EXO1 REV3L POLI POLL POLE POLH RFC5 RFC3 RFC4 RFC2 PARP2 RAD23A ERCC5;BIVM-ERCC5 TERF2 RAD23B DDB1 RAD51C GTF2H2C;GTF2H2C_2;GTF2H2 PNKP FAAP24 UNG RAD54B POLD3 FAN1 POLD4 WRN LOC105377022;FANCB TDG POLD1 POLD2 USP1 PMS2 MUTYH MBD4 CENPX MGMT POLM RPA1 APEX2 GTF2H1 GTF2H3 MLH1 GTF2H4 POLE4 SMUG1 CUL4A ERCC3 ERCC4 POLE2 RPA3 APEX1 ERCC1 POLE3 ERCC2 ERCC8 ERCC6 CUL4B HMGB1-1 BRCA2 POLK PRKDC RAP1A XRCC6 PCNA XRCC5 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260910%WP4814%HOMO SAPIENS Somatic sex determination WT1 RSPO1 PTGDS DMRT1 DHH GATA4 FOXL2 CTNNB1 SOX8 NR5A1 SRY SOX9 WNT4 AMH ZFPM2 FGF9 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260910%WP45%HOMO SAPIENS G1 to S cell cycle control MCM2 POLE2 RPA3 RB1 CDKN1A CDKN1B CDKN1C MCM7 CREB3L3 CREB3L4 CREB3L1 CCND3 CCNA1 CCND2 TFDP1 TFDP2 MCM3 MCM4 MCM5 MCM6 CCND1 PRIM2 MYC ATF6B PRIM1 ORC5 ORC4 CDC45 CDC25A ORC6 ORC1 CREB1 ORC3 CCNE2 ORC2 CDKN2D CDKN2B CCNE1 CDKN2C WEE1 TP53 POLA2 CCNH MDM2-2 CCNB1 E2F1 E2F2 E2F3 GADD45A RPA2 MYT1 CDK6 CDK4 CDK2 CDK1 ATM CDK7 MNAT1 POLE PCNA CREB3 CDKN2A CCNG2 RPA1 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260910%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome STAT5A STAT5B MYC PAK2 TFRC CEP19 HFE SLC40A1 PIGZ CASP7 SENP5 H2BC21 UBXN7 MAD2L1BP-1 SMCO1 PCYT1A NCBP1 FBXW7 ADAM10 SLC51A SLC51B FNDC8 PIGM GRIA1 MYCBP2 RNF168-1 RNF8 FBXO45 HIF1A BRINP1 PIK3R3 TM4SF19 CEP350 MCRS1 PIGX-1 WDR53 SIRT1 ZNF76 RABL2A;RABL2B NCBP2-1 TF DLG1 UBE2N MELTF NRROS NF2 DYNC2H1 HAMP DYNC2I2 JUN CEP43 DYNC2I1 DYNLT1 DYNLT2B DYNC2LI1 DYNLRB2 DYNLRB1 PXN TGFB1 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma MAPK3 BAD STAT3 GAB1 PTPN11 JAK3 CDKN1A HGF RAPGEF1 CBL GRB2 SOS1 CRK SRC CDC42 PAK1 PAK3 PAK2 PAK4 KDR SOS2 VEGFA NRAS MAPK8 PLCG1 PIK3R3 HRAS KRAS JUN ALK ETS1 CRKL ELOA INSL3 TFE3 BUB1B-PAK6;PAK6 RAF1 MET PRCC ARAF RPL11 PAK5 C8orf34 STRN PIK3CD AKT2 AKT3 PIK3CB AKT1 RAP1B RAP1A PIK3R2 BRAF PIK3CA PIK3R1 PTK2 MAP2K2;MAP2K1 MAPK1 RAC1 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260910%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism CYP4F3;CYP4F2;CYP4F12;CYP4F11 FADS2 ACSL1 FADS1 ALOX5 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP560%HOMO SAPIENS TGF beta receptor signaling MAPK9 MAPK3 JAK1 SERPINE1 CREBBP STAT1 ITGB6 STAT3 EP300 CTNNB1 FOS EGF SPP1 IFNG SKIL SMAD7 TNF LEF1 LIF BMP4 RUNX2 HRAS WNT1 SMAD1 SMAD4 JUN TGFBR1-1 TFE3 SMAD2;SMAD3 SMAD9 SMAD5 RUNX3 ZFYVE9 TGIF1-1 FST LEFTY2;LEFTY1 NOG FOXH1 TGFBR3 ZEB2 ENG LTBP1 THBS1 ZNF423 INHBA SMAD6 FKBP1A SKI BAMBI TGFB1 NFKB1 TGFBR2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260910%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 APOA5 LMF1 LIPC APOC2 ANGPTL8 ANGPTL3 ANGPTL4 PLTP GPIHBP1 APOA1 CETP LRP1 SEL1L APOA2 LPL LDLR LCAT NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260910%WP404%HOMO SAPIENS Nucleotide metabolism PRPS2 PRPS1 RRM2B RRM1 ADSL NME2 OAZ1 DHFR2;DHFR SAT1 POLD1 SRM POLA1 IMPDH1 MTHFD2 POLB HPRT1 ADSS2 RRM2-1 POLG ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260910%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ITPR2 GAPDH-1 HSD17B10 IKBKB CHUK RELA APP CALML6 CALML3 CALML4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 ATG14 PSMC2-1 ATG13 DKK2 DKK4 VDAC3 ULK2 ULK1 VDAC1 ATF6 TNF ATF4 APH1A NCSTN GRIN2A PPP3R1 AXIN2 APH1B NRBF2 XBP1 EIF2AK3 EIF2AK2 GRIN2C GRIN2B GRIN2D ATG2A NOX4 CALM1 CALM2 NOX1 ATG2B IDE SLC25A4 RYR3 TUBA1C IL1B PPP3CA PPP3CB TUBA1A PPP3CC PSENEN MAPK8 MME BACE1 CASP8 PSMA5 PSMA6 PLCB3 PSMA3 PLCB4 FADD PSMA4 PSMA1 MAPT TNFRSF1A PLCB1 PLCB2 MAP2K7 TUBB3;TUBB6 PSMA7 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 DDIT3 PSMB2 PSMB3 PSMB1 APBB1 TUBB4B RAF1 CALM3;CALM1 GRIN1 FZD1 PSMA2-1 PSMC5 FZD3 PSMC6 PSMC3 WNT3A PSMC4 WNT5A WNT7A PSMC1 CDK5R1 IRS4 VDAC2-1 WNT3 KIF5C LRP6 AKT2 KIF5B AKT3 KIF5A AKT1 TUBB1 MAP3K5 MTOR CYBB TUBA4A ERN1 ADAM17 PPIF PPID GSK3B RTN3 PIK3R2 PSMD12 PIK3R1 PSMD14 PSMD13 PSEN2 ITPR1 MAP2K2;MAP2K1 CACNA1D GPR83 MAPK1 ITPR3 CACNA1C PSEN1 CACNA1F KLC1 AGER MAPK3 DKK1 RTN4 KLC4 KLC3 KLC2 ATG101 NAE1 BAD CACNA1S TUBA3E;TUBA3C-1 EIF2S1 SEM1 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E MCU TUBA8 ATP2A3 IL6 ATP2A2 ATP2A1 FRAT2 RB1CC1 TUBB2B;TUBB2A TRAF2 CSNK2A2 WIPI1 SFRP4 WIPI2 CSNK2B SLC25A5 SLC25A6 BECN1 TUBAL3 DVL1 BECN2 DVL2 AMBRA1 SNCA DVL3 NOS2 ADRM1 SLC25A31 IL1A FZD10 APC2 AXIN1 CSNK2A1;CSNK2A3 CSNK1A1 WNT5B APC PIK3R4 PIK3R3 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 ARAF CAPN2 CAPN1 WNT2B PIK3CD PIK3CB BRAF WNT16 PIK3CA PIK3C3 LRP5 MAPK9 WNT11 WNT7B MAPK10 CTNNB1 CASP9 CASP3 APAF1 CYCS-1 BID CDK5 FAS IRS1 IRS2 INS;INS-IGF2 CHRNA7;CHRFAM7A NOS1 NFKB1 APOE INSR CSF1 CASP7 ADAM10 NRAS HRAS GNAQ KRAS PTGS2-2 LRP1 LPL VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2877%HOMO SAPIENS Vitamin D receptor pathway IL1RL1 CLMN CREG2 HSD17B2 LRRC8A LRRC25 S100G CDX2 RXRA KRT13 G0S2 MYO9B ATP2B1 DEFB132 CASP5;CASP4 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 PPARD CD9 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DEFB4A;DEFB4B CDKN1A CDKN1B CEBPA CCND1 MYC NRIP1 CCNE1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HNF1A SFRP1 GADD45A NOX1 CDK2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 G6PD FOXO1-1 TNFRSF11B LGALS9C;LGALS9;LGALS9B CTLA4 TGFB2 SULT2A1-4 PRDM1 TGFB1 JUNB CYP27B1 KLF4 CYP2B6 CBS;CBSL CYP2S1 CYP1A1 TNFSF11 SULT1C2 FGF23 STEAP4 SPP1 LPGAT1 GXYLT2 CLDN2 SLC8A1 CYP2D6;LOC107987479;LOC107987478-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 IL12A STS CDKN2D SALL4 CDKN2B SPRR1A;SPRR1B CDKN2C KRT16;KRT14 CYP2C9;CYP2C19 EPHB4 KRT71 PTGER4 IGFBP1 SLC34A2 S100A2 IGFBP3 TPM1 MED9 CDKAL1 CDC34 NINJ1 S100A6 S100A4 S100A9 S100A8 ABCB1 COL13A1 CLEC16A ADRB2 EFNA5 PRKCQ RASGRP1 KNG1 KLK6 CYP7A1 CCNC-1 CRACR2A CRACR2B HIF1A DND1 ALOX5 BTLA CD14 KL SLC37A2 IGFBP5 VDR KRTAP8-1 NFATC2 STAM BMP6 TRPV6 TNFSF4 TRPV5 ID1 PNOC ID4 IGSF9B CLPTM1L MXD1 CYP24A1 CD200 CD40 IL25 TNFAIP3 SLC2A4 ADRA1B TREM1 ORM2;ORM1 THBD ADAMTS5 CASP14 DUSP10 ADGRE5 DNER DACT2 TIMP2 TIMP3 SOSTDC1 BDKRB1 CA9 ABCD1 BCL6 CAMP SERPINB1 IRF4 IRF8 IRF5 COLEC11 SATB1 CDKN2A PTH SEMA3B ASAP2 ATP2C2 TRAK1 ITGAM LRP5 ALPG;ALPP;ALPI-1 CST6 PTHLH CELL CYCLE%WIKIPATHWAYS_20260910%WP179%HOMO SAPIENS Cell cycle MCM2 EP300 RB1 SMC3 CDKN1A CDC14A CDKN1B CDC14B CDC20 CDC23 CDC27 SKP2 ANAPC7 CCND3 CDC25B CCND2 ANAPC4 CHEK2 ANAPC5 MAD1L1 ANAPC1 CHEK1 ANAPC2 E2F4-1 CCND1 ANAPC13 MYC CUL1 PKMYT1 ANAPC10 ANAPC11 SMC1A CDC25C RAD21 CDC25A ZBTB17 PLK1 CDC7 CCNE2 CDC6 STAG1 STAG2 CCNE1 CDC16 YWHAE TP53 YWHAB CCNH MDM2-2 YWHAQ PTTG1;PTTG2 CCNB3 CCNA2-1 CCNB2 YWHAH CCNB1 SMC1B ABL1 RBL1 DBF4 E2F1 RBX1 ESPL1 SFN TTK FZR1 BUB3 GADD45B E2F5 GADD45A BUB1 MAD2L2 WEE2 GADD45G CDK6 HDAC2 CDK4 CDK2 CDK1 ATM CDK7 ATR RBL2 GSK3B YWHAG HDAC1 TGFB2 TGFB1 YWHAZ TGFB3 CDKN1C MCM7 SKP1 CCNA1 TFDP1 TFDP2 MCM3 MCM4 MCM5 MCM6 ORC5 ORC4 CDC45 ORC6 ORC1 ORC3 ORC2 CDKN2D CDKN2B CDKN2C WEE1 E2F2 E2F3 PRKDC SMAD4 SMAD2;SMAD3 PCNA CDKN2A SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260910%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RASGRF1 RAF1 HTR2B HTR2A RASGRP1 ELK4 MAPKAPK2 MAPK3 NRAS HRAS ELK1 GATA4 GNAQ KRAS ITPR1 MAP2K2;MAP2K1 MAPK1 SRF VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260910%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression CACNA1C CYP27B1 ITPR2 TPH1 KDM3A CHRM1 KDM1B RXRA GRM5 CALB1 KDM6B ATP2B1 ATP2B4 ATP2B3 VDR ATP2B2 KCNQ2 KCNQ3 PVALB G6PD GSR TPH2 BCL2 KDM1A GCLC GGT1 GRIN1 SLC8A1 NFE2L2 GRIN2A CYP27A1 GRIN2C GRIN2B GRIN2D ITPR1 ITPR3 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260910%WP206%HOMO SAPIENS Fatty acid omega oxidation ADH4 ADH1C;ADH1B;ADH1A ALDH2 CYP1A1 ALDH1A1 CYP2E1 CYP2A13;CYP2A6;CYP2A7-1 CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260910%WP5548%HOMO SAPIENS Blood based neuroinflammation markers TAC1 TREM1 IL1B GFAP CCL5 TNF CCL13;CCL2 IL6 CRP GRN BDNF ADM TREM2 CX3CL1 CCL23;CCL15 TSPO NEFL CCL11 OLR1 CHI3L1 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260910%WP4155%HOMO SAPIENS Endometrial cancer ILK MAPK3 BAD ELK1 PDPK1 CTNNB1 CDKN1A FOS GRB2 CASP9 SOS1 EGF TCF7 CCND1 MYC ERBB2 DDB2 PTEN FGF2 POLK APC2 TP53 FGF1 AXIN1 AXIN2 SOS2 LEF1 EGFR BAK1 TCF7L2 GADD45B TCF7L1 GADD45A GADD45G APC NRAS PIK3R3 BAX HRAS KRAS RAF1 CDH1 ARAF CTNNA1 CTNNA3 CTNNA2 FGFR3 FGFR2 FGFR1 FOXO3 PIK3CD AKT2 AKT3 PIK3CB AKT1 GSK3B PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260910%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis JAK2 IFNGR1 IFNAR2 JAK1 STAT2 IFNGR2 IFNG TAP1 STAT1 IFI35 IFIT1 PSMB8 IFIT3 PIAS1 MX1-1 TYK2 OAS1 IRF9 PTPN2 IFNAR1 SOCS1 IRF1 IFITM3;IFITM2;IFITM1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260910%WP4971%HOMO SAPIENS Phosphoinositides metabolism MTMR2 MTMR3 MTMR8 MTMR9 MTMR4 MTMR6 MTMR7 MTM1 PLCG2 PIP5K1A PIP5K1B PIP5K1C PIKFYVE PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 INPP5D PTEN PLCG1 PIK3R4 PIP4K2A PLCB3 PLCB4 PLCB1 PLCB2 MTMR10 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG MTMR12 PIK3C2B MTMR11 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2B PIK3CA PIP4K2C SBF1 SBF2 PIK3C3 SACM1L OCRL MTMR1 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260910%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2;SMAD3 TNC RUNX2 CDH1 MAPK3 VIM AKT2 AKT3 AKT1 CDH6 CDH2 SNAI1 SNAI2 ID1 CDH16 SMAD4 FN1 MAPK1 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260910%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MIPEP UBXN1 CLPB MICOS13 TXN2 AIFM1 OPA1 OPA3 C1QBP GDAP1L1 SACS LONP1 UFD1 PMPCB PMPCA UBXN6 SLC25A46 OXA1L AFG3L2 PPA2 CLPP YME1L1 MICU1 PRKN HTRA2 SPG7 DNM1L MFF HSPD1 TIMM50 MSTO1 PITRM1 ATAD3A;ATAD3B MFN1 MFN2 MARCHF5-1 MCL1 HSPA9 DNAJC19 TIMM8A TIMMDC1 USP9X TXNRD2 AGK TMEM126A-1 PYCR2 PYCR3 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 VCP-1 PYCR1 PLEK STAT2 TRAK1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260910%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGM PIGS PIGX-1 PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGQ PIGP PIGW PIGV PIGC DPM2 PIGB PIGA PIGK MPPE1 PIGL PIGG PIGF PIGH INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260910%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway BMP2 DDR1 NQO1 SUV39H1 ANXA5 LOXL4 NRF1 ECSIT PKD1 COL2A1 CDC37 EXOC6 NFE2L2 SIRT1 IGFBP7 FGF7 TGFB1 FN1 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260910%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface CXCL10 SMAD2;SMAD3 IL2RA ITGAE FOXP3 IFNG CD14 SMAD7 CD9 ANGPT2 ITGA1 ANGPT1 CD4 SMURF2 VEGFC FCGR3A;FCGR3B KLRC4-KLRK1;KLRK1 SMAD4 NCAM1 TGFB1 TGFBR1-1 PGF CXCL8 TGFBR2 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260910%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups GATM CPS1 SMS SARDH PYCR3 ASL NAGS CKB OTC PYCR1 SRM GLUD1;GLUD2 GAMT ARG2 ACY1;ABHD14A-ACY1 ALDH18A1 OAT CKM ARG1 ODC1 ASS1 FOLATE METABOLISM%WIKIPATHWAYS_20260910%WP176%HOMO SAPIENS Folate metabolism SCARB1 SERPINA3 MTRR SLC46A1 SERPINE1 PLAT FLAD1 MTR-1 RFK MPO GPX6 ICAM1 IZUMO1R SLC19A1 SAA2;SAA1 FOLR2 CBS;CBSL FOLR1 FGB FGA SAA2-SAA4;SAA4 FGG IL6 APOA1 MAT1A F2 RELA F7 SHMT2 PLG HBD;HBB LDLR ABCA1 INSR MTHFR IL2 SOD2 SOD3 IL4 SOD1 IFNG HBA2;HBA1 CTH ALB TNF TP53 CSF1 CAT ST20-MTHFS;MTHFS IL1B AHCY SHMT1 DHFR2;DHFR MTHFD1 MTHFD2 GPX1 GART GPX4 INS;INS-IGF2 APOB CCL13;CCL2 CRP NFKB1 NFKB2 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260910%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S1 EIF2S2 EIF2S3;EIF2S3B EIF1 EIF3C;EIF3CL EIF5 EIF3I EIF1AY;EIF1AX EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders TAT FAH HPD GSTZ1 HGD PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260910%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELPLG IL1B VCAM1 PF4;PF4V1-1 SELE SELP CD40LG CCL5 TLR2 TLR7 ICAM1 TLR4 CCL13;CCL2 TGFB2 TGFB1 TGFB3 CD40 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260910%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway RASGRF1 JAK2 HTR2A RASGRP1 ELK4 MAPK3 MAPKAPK2 GNAI1 MAPK14 STAT3 ELK1 PDPK1 RHOA GNAQ FOS MAP2K6 MAP2K3 MAP3K1 GNAI3 CREB1 GNAI2 RPS6KA5 HTR1E HTR1F HTR1D HTR1A HTR1B GNAO1 RAP1A BRAF MAPKAPK3 PIK3CA ITPR1 MAP2K2;MAP2K1 MAPK1 SRF INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260910%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MYD88 TRAF6 MAP3K7 MAPK9 MAPK3 MAPKAPK2 NFKBIB MAP2K4 MAPK8 MAPK14 ATF2 ELK1 IKBKB MAPK10 MAPK11 CHUK FOS MAP2K7 EIF4E RELA MAP2K6 MAP2K3 MAP3K1 NFKBIA MYC IL1A IL1R1 RPS6KA5 MBP IL1RAP TANK IRAK1 IRAK2 MKNK1 MKNK2 MAP3K8 MAP3K3 IRF7 SAFB TOLLIP IRAK4 TAB3 MAP2K2;MAP2K1 NFKB1 TAB2 MAPK1 TAB1 MAP3K14 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260910%WP4157%HOMO SAPIENS GABA metabolism aka GHB PON3 ALDH5A1 MAOB GLS2 GAD1 GLS ADHFE1 DPEP1 GAD2 ABAT AKR7A2 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma JAK2 IL6R JAK1 IL11RA ZEB1 STAT3 IL11 JAK3 IL6 RELA IL6ST SOX4 NFKB1 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260910%WP4918%HOMO SAPIENS Cellular proteostasis PFDN5 PFDN6 PFDN4-1 VBP1 PFDN1 PFDN2 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260910%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function SLC2A1 PRKCA C3-1 PRKCQ AGER PRKCD PRKCZ MMP1 MMP21 MMP20 MMP25 MMP24 MMP27 MMP2 MMP28 BDNF SCN9A TKTL1 MMP9 MMP7 TRPA1 MMP3 SORD TRPV1 MMP8 MMP10 MMP12 NOS2 MMP11 SCN10A MMP14 MMP13 MMP16 PRKD3 MMP15 SNAP25 MMP23B SCN8A MMP17 MMP19 PRKCG PRKCI PRKCH PRKCB PRKCE AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260910%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GLYAT ACSS2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260910%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A NAD METABOLISM%WIKIPATHWAYS_20260910%WP3644%HOMO SAPIENS NAD metabolism PARP1 NRK SIRT4 SIRT5 NMNAT3 SIRT1 NMNAT2 SIRT2 SIRT3 SIRT6 NMNAT1 NAMPT CD38 NADK NT5E FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260910%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling PFKFB2 PRKAA1 ATF2 PPARGC1A IKBKB FGF21 JAK3 RHEB PRKAA2 EGF FN1 LIPE EPO TNC KDR PDGFB ULK1 PDGFRB FGF2 ATF4 KIT IGF1 EIF4E CREB3L2 RAF1 IRS4 AKT2 AKT3 AKT1 MTOR GSK3B TCL1B PIK3R2 TCL1A PIK3R1 PPP2R1B PPP2R1A DDIT4 PPP2R2A;PPP2R2D MAP2K2;MAP2K1 EPHA2 MAPK1 EPAS1 LPAR2 JAK2 LPAR3 IL6R LPAR4 GNG10 PDGFD MAPK3 PDGFC JAK1 NGFR GNG13 COL1A1 COL1A2 LPAR5 BAD LPAR6 CAB39L HIF3A GYS2 GNGT1 GYS1 IKBKG RAB8A STRADA OSMR PHLPP2 IGF1R RPS6KB1 TNXB GRB2 PHLPP1 CAB39 COL11A1 COL11A2 SOS1 RELN VEGFB OSM VEGFD RAB11B KITLG COL3A1 FGF20 CHRM2 NOS2 CSF3R IL2 STK11 FGF22 IBSP TNN FGF17 TNR FGF16 RAB2A PDGFRA FGF19 F2R FLT4 COL4A2 COL4A1 PTEN EIF4E1B COL4A4 COL4A6 PFKFB1 FGF1 CSF1R FGF3 PFKFB4 FGF4 PFKFB3 EFNA4 EGFR FGF6 HSP90B1 FGF7 VTN FGF8 CHAD FGF9 EFNA1 EFNA3 EFNA2 FGF14 COL5A1 COL5A3 GNB2 COL5A2 GNB1 RPS6KB2 GNB4 EFNA5 GNB3 IL7R FGF13 FGF12 FGF11 HSP90AB1 LAMC3 SLC2A2 PIK3R4 LAMC2 LAMC1 ELAVL1 GHR PIK3R5 HSP90AA1 VWF PPP2R5B PPP2R5A PPP2R5D NGF TBC1D1 COL6A2 IL3RA EIF4E2 CREB5 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 THBS4 SLC2A4 THBS3 ITGA2B GNG2 GNG5 FGF18 PPP2R3C FGFR4 GNG4 GNG8 FGFR3 EIF4B FGFR2 ANGPT4 LAMB3 FGF10 NOS3 FGFR1 LAMB2 LAMB1 FOXO3 PPP2R3A PIK3CD EPOR RAB10 PIK3CB PPP2R2C PIK3C2A RAB14 PIK3CG PIK3IP1 PPP2R2B PIK3C2B TEK PPP2R5E PPP2R5C PTK2 CRTC2 PIK3CA ITGA10 FLT1 ITGA11 ITGB1 ITGAM PGF ITGB5 ITGB4 ITGB3 ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGAV ITGB7 ITGB6 ITGA4 PDPK1 ITGA3 ITGA2 CDKN1A CDKN1B ITGAD ITGA8 ITGA7 ITGA6 CASP9 ITGA5 ITGA9 COMP CREB1 IFNB1-4 MDM2-2 CHRM1 FOXA1 SREBF1 IRS1 IRS2 FOXO1-1 ACACA INS;INS-IGF2 PPP2CB;PPP2CA IFNAR2 NOS1 TSC2 IFNAR1 PRL IL2RG RPS6 IL4R PRLR EIF4EBP1 IL2RA IL2RB CSF3 HGF CREB3L3 CREB3L4 CREB3L1 PDGFA INSR ATF6B SPP1 CSF1 VEGFA SLC2A1 LPAR1 NRAS HIF1A HRAS KRAS MET RPTOR MLST8 COL2A1 CDC37 ANGPT2 TSC1 ANGPT1 THBS1 VEGFC CREB3 AKT1S1 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260910%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 MYC MAPK3 ELK1 FOS SOS2 KSR1 GAREM2 KRAS BRAF JUN ALK SOS1 SHC1-1 MAP2K2;MAP2K1 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260910%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases SNCA MAOB STAT1 BACE1 AKT2 AKT3 AKT1 MAPT SRPK2 NTRK2 BDNF APP SET-1 TARDBP LGMN CEBPB PPP2CB;PPP2CA METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260910%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway TAT IL4I1 MTAP MAT2A SMS ADI1 MSRB2 AHCY MSRB3 ENOPH1 MAT2B MTR-1 BHMT SRM CHDH MAT1A AMD1 APIP MRI1 ODC1 TXN MSRA CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260910%WP3594%HOMO SAPIENS Circadian rhythm genes PRKAA1 PPARGC1A EP300 AGRP PRKAA2 NRIP1 ATF4 HNF1B MAPK8 JUN PROX1 NAMPT GSK3B HDAC1 NGFR TPTEP2-CSNK1E;CSNK1E NR2F6 IL6 PHLPP1 SKP1 NOS2 PTEN PRKCG AHCY PRKDC TYMS ID4 HS3ST2 RORC RORA PPARG MAPK9 PRF1 HNRNPU CCAR2 HTR7 PROK2 BTRC PROK1 UTS2R MAPK10 CPT1A METTL3 SOX14 CSNK1D CLDN4 ATF5 UBA52 CLOCK DHX9 MAGED1 NKX2-1 OGT-1 EGR1 JUND EGR3 HOMER1 ROCK2 NR1D2 NR1D1 SETX STAR CUL1 NMS HNRNPD ID3 FBXL3 ADA ID2-1 TOP2A CREB1 SUV39H2 BHLHE41 PRMT5 NCOA2 KCND2 TP53 PAX4 MC3R NCOR1 KCNMA1 AVP PPARA CIPC DDC ADCY1 ARNTL2 RELB ARNTL CST3 NPS PROKR1 PROKR2 NFIL3 PML SIK1;SIK1B RPS27A UBB;UBC ARNT2 CAVIN3 NR1H3 HDAC2 TPH1 PPP1CA CDK4 PER2 PER1 CHRM1 MYBBP1A GHRH FAS GHRL LGR4 EZH2 CRTC1 NPY2R UBE3A RORB PPP1CB PPP1CC SREBF1 NAGLU ADORA1 CHRNB2 FBXW11 MTTP KCNH7 ADIPOQ USP2 DYRK1A CARTPT TPH2 SLC9A3 MTNR1A MTNR1B PSPC1 TIMELESS DDX5 MAGEL2 KMT2A SLC6A4 CREM TNFRSF11A NPAS2 RAI1 AANAT DRD1 DRD2 DRD3 DRD4 ZFHX3 OPN4 OPN3 ADORA2A TH NONO GFPT1 BTBD9 BHLHE40 RBM4;RBM4B KDM5A HEBP1 DBP SIN3A SIX3 SFPQ-1 KLF10 ARNT THRAP3 CRY2 CRY1 CRH TOP1 NLGN1 HDAC3 CRX OPRL1 CIART ATOH7 MTA1 SERPINE1 GNA11 NOCT NTRK1 NTRK3 HCRTR2 HCRTR1 LEP KLF9 SFTPC F7 AHR PTGDS SIRT1 GNAQ SUV39H1 PRKG2 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP5094%HOMO SAPIENS Orexin receptor pathway EIF4EBP1 MAPK9 MAPK3 MAPK7 PRKAA1 GNA11 NPY PRKCD MAPK14 STAT3 HCRTR2 HCRTR1 PDPK1 PTPN11 LEP NPFFR1 DAGLA PLCD1 ARRB1 POMC ARRB2 SGK1-1 IL6 FSHB RPS6KB1 RRAGC LHB CASP9 SLC1A2 PDHB PLD1 CAMKK2 NPVF CASP3 IL10 VHL CGA CXCL8 HCRT OPRK1 GCG CCK STAR IL9 GNRH1 IL4 CREB1 BMP7 TNF NFE2L2 CXCL2;CXCL3;CXCL1-1 NOX4 PRKCB PRKCE SLC2A1 PRKCA RUNX2 IL1B PRKD1 GRIA1 GNAI1 MAPK8 HIF1A GHRL PRKCZ GNAS-1 RPS6KA1 GNAQ SMAD1 ADIPOQ FOXO1-1 DYNLT1 SLC2A4 SMAD5 EIF4B BMPR1A PDK1 TH MTOR RPS6 PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260910%WP5443%HOMO SAPIENS Effects of MFN2 mutation SNCA RAB3B DCTN1 ATAT1 DYNC1LI2 RHOT1 SYPL1 RAB3A CASP8 MAP2 BAX KIF1B RABAC1 RAB7A TP53 DYNC1I1 TUBB3;TUBB6 DYNC2H1 MFN2 DYNC2I2 DYNC1H1 DYNC2I1 TRAK1 CASP3 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260910%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC3 HDAC2 PPP3CA PPP3CB PPP3CC CREBBP EP300 NFATC2 RELA NFKBIA NFATC1 SP1 HDAC4 HDAC5 CCNT1 HDAC8 HDAC9 PPP3R1 HDAC7 NELFB NELFA NELFCD HDAC1 NELFE SUPT4H1-1 HEXIM1 NFATC3 SUPT5H NFATC4 NFKB1 CDK9 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260910%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production PRKCA CLCN5 SLC26A6 MAPK3 PRKAA1 SLC5A5 TPO ELK1 DUOX2 TSHR PLCD1 TG PRKAA2 CGA TRH RAF1 CREB1 RAP1B RAP1A ACY1;ABHD14A-ACY1 MAP2K2;MAP2K1 NFKB1 DUOX1 MAPK1 ANO1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260910%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV NLGN1 NLGN3 CAMK2B CYFIP1 MAPK3 RYR2 CAMK2D NLGN2 FMR1 CAMK2A NRXN3 NRXN2 GRM1 RPH3A SYNGAP1 DLGAP1 CAMK2G NLGN4X;NLGN4Y NRXN1;NRXN3;NRXN2 TJP1 ARC DLG1 DLG2 SHANK1 HOMER1 GRIN1 GRIN2A STX1A YWHAG GRIN2C GRIN2B GRIN2D MAPK1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260910%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 F12 BDKRB2 SERPING1 KLKB1 CPN1 BDKRB1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2881%HOMO SAPIENS Estrogen receptor pathway SP1 STAT3 ACOX1 CYP1A2 CYP1B1 CYP1A1 PPARA JUN NR0B2 GPAM ESR1 PDK4 PCK1 SARS COV 2 ENVELOPE LIPID COMPOSITION AND HUMAN CELL BINDING%WIKIPATHWAYS_20260910%WP5255%HOMO SAPIENS SARS CoV 2 envelope lipid composition and human cell binding AXL CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260910%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism CYB5A H6PD CYP19A1 STAR SRD5A2 HSD17B3 HSD11B1 CYP17A1 HSD11B2 POR HSD3B1;HSD3B2 CYP11A1 CYP21A2 CYP11B1;CYP11B2 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260910%WP5574%HOMO SAPIENS Oligodendrocyte development PRKCA BMP4 MAG NFATC2 SOX11 SOX2 SMAD1 BMP1 WNT10A ID4 RELN ID2-1 MYRF PDGFRA CHD8 CHD7 ASCL1 PTN FGF2 EGR2 ZNF24 DUSP15 GLI2 SHH PTPRZ1 SOX8 NKX6-1 ZEB2 MBP ZNF488 SOX9 LGI1 SOX6 OPALIN SOX5 ZBTB33 NKX2-2 TMEM98 NKX2-6 NFIA CNTN1 CSPG4 HES5 TCF7L2 OLIG1 OLIG2 MYT1 SOX10 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260910%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260910%WP2363%HOMO SAPIENS Gastric cancer network 2 BRIX1 UBE2C ATAD2 FANCI CACYBP FAM91A1 RNF144B UBE2T SNURF CEBPZ RAD17 CD48 LBR CTNNB1 RFC3 RFC4 MYC TOP2A COL9A1 COL9A3 TP53 EGFR OTUD5 AHCTF1 S100A6 DSCC1 CHTF18 LMNB2 MTDH PLAC8 ESTROGEN SIGNALING%WIKIPATHWAYS_20260910%WP712%HOMO SAPIENS Estrogen signaling GNB1 MAPK9 PRKACA-1 SP1 CREB1 GPER1 MAPK14 ELK1 IKBKB GNGT1 AKT1 CHUK GNAS-1 IKBKG FOS BRAF JUN PIK3CA NFKB1 MAP2K2;MAP2K1 BCL2 ESR1 MAPK1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260910%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance CDKN1A HIF1A BCL2L1 ABCB1 WNT6 TP53 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260910%WP3927%HOMO SAPIENS BMP signaling in eyelid development BMP4 TGFA SMAD5 MAPK9 MAPK3 NOTCH1 DKK2 FGFR2 FGF10 FOXC2 FOXC1 INHBB PITX2 SHH SMAD1 EGFR SFRP1 SMAD4 JUN MAP3K1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades C3-1 C1QC SERPINA1 SERPINE1 PLAT PLAU PROS1 CLU FGB SERPINA5 C8G C3AR1 LOC110384692;C4A;C4B_2;C4B CR2 SERPINF2 PLAUR F2 F3 F7 F5 F8 PLG F9 MASP2 MASP1 CFB CFD C1QB CPB2 C1S C1R SERPINC1 CFI C5AR1 TFPI C2 LMAN1 F2R C6 CLTC C7 C9 CD55 F10 SERPIND1 CR1L;CR1 PROC F13B CFH-3 KNG1 VWF F12 SERPING1 KLKB1 THBD BDKRB1 APOA2 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260910%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC6A3 SLC18A2 PNMT COMT DDC TPH1 MAOA TPH2 TH DBH CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260910%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC3 ABCC2 CYP2D6;LOC107987479;LOC107987478-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260910%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders PDXK PNPO ALPL PLPBP ALDH7A1 PIGV ALPG;ALPP;ALPI-1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260910%WP363%HOMO SAPIENS Wnt signaling NetPath PRKCA TCF4 ROR1 MAP3K7 CDK6 ROR2 MAPK9 PI4K2A CSNK1G1 MAPK8 PIP5K1B NFATC2 CTNNB1 TPTEP2-CSNK1E;CSNK1E RHOA CSNK1D ARRB2 DVL1 DVL2 CCND1 DVL3 TSC2 LRP6 AKT1 MTOR AXIN1 TSC1 LEF1 GSK3B PRKCG GSK3A CTBP1 NLK TCF7L2 PPARG SOX1 LRP5 GCKR CSNK1A1 MAPK1 PRKCB RYK-1 RAC1 BCL9 APC FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260910%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 STAT3 IL10 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260910%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PI4K2A MOGAT3 PLA2G2A-1 PGS1 PTDSS1 GPAT4 PIP5K1A PTPMT1 GPAT3 GPAT2 CEPT1 CDIPT CHKB PCYT2 GK IPMK CRLS1 GNPAT GPD1 AGPS PEMT CHPT1 LPIN1 LPIN2 CDS2 GPAM PIK3CD PIK3CB PIK3CG PIK3CA PPAR SIGNALING%WIKIPATHWAYS_20260910%WP3942%HOMO SAPIENS PPAR signaling UBB;UBC APOA5 ILK EHHADH-1 UCP1 NR1H3 CYP7A1 ANGPTL4 RXRA PLTP CD36 ACAA1-1 ACOX1 PDPK1 PPARD MMP1 GK CYP8B1 APOA1 ADIPOQ SLC27A1 RXRB CPT2 OLR1 SLC27A5 ME1 PCK1 HMGCS2 RXRG APOC3 CPT1C FABP1 FABP3 FADS2 FABP4 ACSL1 SCD SORBS1 SLC27A4 SCP2 PCK2 PPARA LOC100509620;LOC112267859;AQP7 CYP27A1 PPARG APOA2 LPL PLIN1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260910%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation MTOR PIK3CG GRK1 PIK3CA FPR2 EPHB2 PDK1 LTB4R PIK3CD CMKLR1 AKT1 PIK3CB ID SIGNALING%WIKIPATHWAYS_20260910%WP53%HOMO SAPIENS ID signaling ELK4 ID3 CDK2 ID2-1 RBL2 ELK1 CCNE1 PAX5 ELK3 RB1 SREBF1 PAX2 RBL1 ID1 MYOD1 PAX8 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260910%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia IL6R IL1B JAK1 STAT3 IKBKB EP300 MAPK11 IKBKG CHUK TNFRSF1A IL6 IGF1R RELA SMAD4 NFKBIA CEBPB SMAD2;SMAD3 RPTOR IL1A IL1R1 FBXO32 MLST8 PDK1 FOXO3 TNF AKT1 MSTN MTOR MAP1LC3A TRIM63 TNFRSF12A ACVR2A REL RELB IGF1 AKT1S1 NFKB1 NFKB2 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260910%WP550%HOMO SAPIENS Biogenic amine synthesis COMT TPH1 GAD1 AANAT GAD2 TH PNMT DDC MAOA HDC CHAT ASMT PAH ACHE DBH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP138%HOMO SAPIENS Androgen receptor signaling ZMIZ1 RACK1 PIAS4 NCOA4 ETV5 PIAS2 NCOA1 TLE5 RHOB NCOR2 CREBBP AR ZNF318 FKBP4 RNF6 STAT3 RNF4 NR2C2 EP300 PSMC3IP PRDX1 CTNNB1 RB1 BAG1 RLN2;RLN1 PATZ1 SMARCE1 UBE2I BRCA1 LIMK2 RELA DSTN CARM1 FLNA STUB1 RAN ROCK1 ROCK2 SRC CDC42 CCND1 SP1 CREB1 PTEN NCOA2 CCNE1 PARK7 NCOA3 MDM2-2 NCOR1 EGFR RUNX2 UBE3A RAD9A SIRT1 RHOA SMAD4 FOXO1-1 JUN TGFB1I1 NR0B2 KDM1A BUB1B-PAK6;PAK6 SMAD2;SMAD3 KAT2B TGIF1-1 PIAS1 AKT1 DAXX GSK3B SIN3A PIAS3 HDAC1 CAV1 PIK3R2 PIK3R1 PTK2 CALR-1 RNF14 FHL2 EFCAB6 KAT5 SMIM40 SUMO1 RAC1 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260910%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY3 MAPK3 ADCY8 NRAS HRAS WWTR1 CCN2 LBR RHOA MAP3K9 KRAS SMAD4 GRB2 SOS1 ADCY4 ADCY2 SYNE4 SYNE3 ADCY7 ADCY6 SMAD2;SMAD3 SYNE2 SYNE1 ADCY5 TMEM43 CFL1 BANF1 EMD TMPO SUN1 LEMD3 ADCY10 ADCY9 KIF5B PLEC SOS2 ADCY1 TGFB2 TGFB1 TGFB3 MAP2K2;MAP2K1 MAPK1 SRF ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5393%HOMO SAPIENS Androgen biosynthesis SRD5A2 AKR1D1 HSD17B2 HSD17B3 HSD11B1 CYP17A1 HSD11B2 POR HSD3B1;HSD3B2 SRD5A1 HSD17B4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B1 SULT2A1-4 CYP11B1;CYP11B2 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma CS MDH2 NMRK2 HSPE1 SLC19A2 FH NONO TFE3 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP4159%HOMO SAPIENS GABA receptor signaling GABRA1 GABRP AP2B1 GABBR1 GABRA6 GABRA5 GAD1 GABRA4 GABRA3 SLC6A11 GAD2 GABRG1 ABAT ALDH9A1 AP2S1 SLC6A1 AP2A1 AP2A2 AP2M1 GABRB3 GABRB2 GABRB1 GPHN GABRG3;GABRG2 SLC32A1 GABRE GABRD GABRQ GABRA2 GABBR2 SIGNALING LIPIDS%WIKIPATHWAYS_20260910%WP5584%HOMO SAPIENS Signaling lipids HPGD ALOX15 ALOX12 LTC4S CYP7A1 CYP2B6 ALOX5 PLA2G1B LTA4H PTGDS CBR1-1 PLA1A EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PRXL2B PLCB1 CYP8B1 TBXAS1 GPX4 PTGS2-2 FADS2 CYP2C9;CYP2C19 CYP7B1 CYP27A1 PTGES SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1B1 FMO3 MSRB2 MSRB3 CYP1A2 MSRA NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260910%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection NPR1 CAMK2B IL1B CAMK2D CAMK2A BAD GUCY1B1 XIAP AKAP9-1 NPPA CAMK2G CNGA1 CNGA2 CNGA3 CNGA4 GUCY1A2 GUCY1A1 RELA ACTN2 CASP9 PDE2A DLG4 PDE3A CNGB3 TSPO NFKBIA CNGB1 NEFL BCL2 NOS2 GRIN1 NPPB NOS1 IFNG NOS3 CREB1 PRKG2 TNF CYCS-1 GRIN2A PPID GRIN2C GRIN2B GRIN2D NFKB1 CALM1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260910%WP5178%HOMO SAPIENS Disorders of fructose metabolism KHK PFKL ALDOB FBP1 SLC2A2 HK1 PGM1 G6PC1 ALDH1A1 TPI1 SORD GLYCTK GPI SLC5A1-1 IL11 SIGNALING%WIKIPATHWAYS_20260910%WP2332%HOMO SAPIENS IL11 signaling JAK2 RUNX2 MAPK3 JAK1 STAT1 IL11RA ICAM1 HRAS STAT3 IKBKB YES1 PDPK1 PTPN11 TYK2 ITGA2 CHUK RPS6KA1 RPS6KB1 RELA GRB2 IL6ST FES BCL2 SRC RAF1 ATF1 PTPA IBSP BIRC5 CREB1 FYN IL11 PIAS1 AKT1 PIAS3 PIK3R2 RPS6 PIK3R1 TGFB1 SOCS3 MAP2K2;MAP2K1 MAPK1 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260910%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids CDS1 DGAT2 PTDSS1 DGAT1 GPAT4 PLA2G1B DGKZ PISD AGPAT4 PTDSS2 ETNK1 CDIPT CHKB PNPLA3 PCYT2 CRLS1 PEMT PNPLA2 CHPT1 PLD1 PCYT1A GPAM MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260910%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260910%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation MAPK3 PLCG2 PLCG1 MAPK14 IL12B PLCB3 IKBKB PLCB4 PLCD3 PLCD4 IKBKG CHUK PLCD1 PLCB1 IL6 PLCB2 RELA NFKBIA CXCL8 IL12A PIK3CD TNF AKT2 AKT3 PIK3CB AKT1 PIK3CG RETN PLCE1 PIK3CA ITPR1 NFKB1 MAPK1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2858%HOMO SAPIENS Ectoderm differentiation MZF1 ASTN1 LY6E ARX GATA6 STC1 ARHGAP15 ZBTB2 TRPM2 SDCBP PODXL ST8SIA4 HESX1 PLXNA2 ZBTB7B GAS2L1 PPARD TFAP2A CTNNB1 TFAP2C JUP SMURF1 ZBTB16 GREB1 NR2F2 POU2F2 ZFHX4 PAN2 OGT-1 AHI1 PLCXD3 PRKAG2 PTPRB PPFIBP2 MAFB CCDC88C PI4KA MKS1 MYC CCDC130 EDA NUMA1 HMGB2 LDB2 EDA2R WDR44 PHF8 SIX6 BOC UBTF RAB8B BCAS3 SHH ELOVL4 TSC22D1 ELOVL2 PAX3 SORCS1 PAX6 BAZ1A FOXL1 RGMA CLDN11 ARHGAP10 TOX3 CTBP1 KIFC3 STX16 RRBP1 JAKMIP1 HDAC6 BMP4 IQCJ-SCHIP1;SCHIP1 DMD ROR2 SERPINB6-2 CLVS1 CAP2 TTC14 C1GALT1 PTPN13 VAX2 LHX1 RIT1 GLB1 SGSM3 ZNF219 SPRY2 BCOR PDE7A TRIM33 MYORG ABCC4 SOX2 TNFRSF11B FOXA2 CTNNA2 FYN CCL13;CCL2 NLK FHL2 SOCS2 NLGN1 TLE5 MECP2 CDH6 SNCA SKIL TCF7L1 PGM1 WNT1 SMAD4 NF2 FZD5 FZD4 FZD8 NFATC1 FGFR2 BMPR1A GLI3 HDAC10 CTNND2 ARHGDIG CELSR2 TSKU CDH8 NARS2 PIM1 ANKS1B CDON KCNK10 GRAMD1B-1 KRT6B;KRT6C;KRT6A METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases LIPC APOC2 SCARB1 ANXA2 PCSK9 LIPG APOA1 LDLRAP1 MTTP CETP APOA2 APOE APOB LPL LDLR ABCA1 LCAT AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260910%WP1403%HOMO SAPIENS AMP activated protein kinase signaling EIF4EBP1 PRKAA1 GYS2 LEP CPT1A GYS1 CDKN1A STRADA RPS6KB1 PRKAA2 CAB39 PRKAG1 CCNA1 PRKAG2 CAMKK2 PRKAG3 PRKACB-1 LIPE PRKAB2 INSR STK11 PRKAB1 HNF4A TP53 CCNA2-1 PFKFB3 CCNB1 RPS6KB2 PIK3R3 ELAVL1 SREBF1 PLCB1 ADRA1A EEF2K ADIPOQ LEPR STRADB ACACA INS;INS-IGF2 CPT1B ADIPOR1 ACACB FASN ADIPOR2 CAMKK1 PPARGC1B EEF2 SLC2A4 SLC2A4RG ADRA1B RPTOR CPT1C TSC2 PIK3CD AKT2 PIK3CB AKT1 MTOR PIK3CG HMGCR TSC1 PIK3R2 CRTC2 PIK3CA PIK3R1 PIK3C3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260910%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway IL1B CASP8 DUOX2 CASP5;CASP4 XIAP IKBKB HSP90AA1 IKBKG CHUK RELA CASP9 NOD2 NFKBIA IL18 NDUFA13 NOD1 NLRC4 MEFV NLRP7;NLRP2 NLRP4 NLRP1 AAMP RIPK2 CARD9 ERBIN CARD6 NLRP12 COPS6 ACAP1 AIM2 NLRP10 SUGT1 NAIP PYCARD CASP7 CASP1 NLRP3 PRDM1 RAC1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260910%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response TRIB3 ERP27 ATF3 BBC3 DDIT3 BCL2L11 ATF6 ATF4 NFE2L2 ERN1 PPP1R15A HSP90B1 NARS1 XBP1 DNAJB9 EIF2AK3 EIF2A HSPA5 UBE2E1 CALR-1 ASNS EDEM1-1 PDIA6 WARS1 DNAJC3-1 DNAJB11 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling GCLM GSTP1 NQO2 SRXN1 ABCC6 NQO1 HMOX1 ABCG2 CES1 MAPK8 MAPK14 MAPK12 MAPK13 EPHX1 MAPK11 NFE2L2 ABCC3 KEAP1 ABCC4 FOS ABCC2 JUN GCLC AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260910%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS GRIA1 PPP3CA PPP3CB PPP3CC TOMM40 DERL1 NEFM BAD NEFH MAPK14 BAX PRPH CCS ALS2 RAB5A TNFRSF1A GPX1 MAP2K6 SLC1A2 CASP9 BCL2L1 CASP3 NEFL BCL2 APAF1 NOS1 SOD1 TNF TP53 MAP3K5 DAXX CASP1 BID CAT CST3 MAP2K2;MAP2K1 SMIM40 RAC1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5103%HOMO SAPIENS Progeria associated lipodystrophy SMAD2;SMAD3 ICMT LMNA BANF1 ZMPSTE24 PARP1 WRN KCNJ6 POLD1 MUCL3 RECQL LMNB1 FNTA FFAR3;GPR42 SPRTN SMAD4 FBN1 TGFB1 INS;INS-IGF2 PPARG LMNB2 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260910%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A2 RETINOL METABOLISM%WIKIPATHWAYS_20260910%WP5188%HOMO SAPIENS Retinol metabolism LRAT RDH13 BCO1 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP1A1 ALDH1A1 RPE65 DHRS4 SDR16C5 CYP2W1 DHRS9 RDH12 AWAT2 PNPLA4 AOX1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260910%WP3407%HOMO SAPIENS FTO obesity variant mechanism FTO TBX1 UCP1 IRX5 IRX3 ARID5B PRDM16 PPARGC1A CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260910%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R3 PIK3CD PTPN11 CD86 PIK3CB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD80 CTLA4 PIK3R2 PIK3R1 PIK3CA CD28 PPP2CB;PPP2CA PTPN6 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GALT2 B3GNT5 B3GALT1 FUT2 FUT1 FUT6;FUT5;FUT3 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260910%WP615%HOMO SAPIENS Senescence and autophagy in cancer MAPK14 RB1 CDKN1A CDKN1B CDC25B FN1 SRC ATG14 ATG13 ULK1 IFNB1-4 TP53 MDM2-2 IL3 E2F1 CXCL2;CXCL3;CXCL1-1 IGF1 BMP2 IL1B MAP2K3 JUN INS;INS-IGF2 BCL2 RAF1 KMT2A MMP14 MTOR MAP1LC3A GSK3B TGFB1 MAP2K2;MAP2K1 MAPK1 IL6R SERPINE1 COL1A1 PLAT PLAU IL6 IGF1R RB1CC1 IRF1 IL6ST CCL3L1;CCL3L3;CCL3;CCL18 BECN1 CEBPB CXCL8 AMBRA1 COL3A1 IL1A IFNG PTEN SPARC CXCL14 LAMP1 LAMP2 SLC39A2 SLC39A1 SLC39A4 SLC39A3 IGFBP3 SH3GLB1 ATG3 VTN MAP1LC3B2;MAP1LC3B-1 GABARAPL2 ATG10 IRF7 ATG12-1 FKBP8 SQSTM1 GABARAP ATG7 ATG5 UVRAG TNFSF15 ATG16L1 IL24 BMI1 ING1 ING2 MAP1LC3C COL10A1 SERPINB2 CD44 RNASEL HRAS IFI16 CREG1 IGFBP5 GSN RSL1D1 SMAD4 SMAD2;SMAD3 MLST8 IGFBP7 THBS1 PCNA INHBA IRF5 CDKN2A BRAF AKT1S1 PIK3C3 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260910%WP26%HOMO SAPIENS S1P receptor signal transduction MAPK3 GNAI1 MAPK7 MAPK6 MAPK4 MAPK12 PLCB3 ASAH1 SMPD2 RACGAP1 S1PR1 PLCB1 S1PR3 PLCB2 S1PR2 S1PR5 SPHK2 SPHK1 GNAI3 GNAI2 AKT2 AKT3 AKT1 PIK3C2B MAPK1 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260910%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PRKCA MAPKAPK2 CDK1 NTRK1 NTRK3 STAT3 GNAQ MAPT TRIO TESK2 AURKB MAPRE1-1 ROCK1 SPRED1 PARD6A SRC DPYSL2 DVL1 CDC42 CFL2 PAK1 STMN1 RHO TPPP MARK2 CLASP1 PRKACA-1 MARK1 WNT3A LIMK1 TIAM1 DIAPH1 CLIP1 PTPRA EPHB2 TAOK1 PTEN CAMK4 MAP1B KIF2C AKT1 PHLDB2 F2RL2 ABL1 GSK3B NTRK2 RAC1 APC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260910%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy MTMR2 NEFL RAB11B RAB3B RAB3A KIF1B RABAC1 EGR2 RAB7A LRSAM1 HSPB8 HSPB1 NDRG1 LITAF FGD4 SH3TC2 RAB25 MFN2 MPZ RAB4A RAB4B SBF2 GDAP1 RAB11A FIG4 DNM2 PMP22 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260910%WP5145%HOMO SAPIENS COVID 19 structural coverage map NRP1 IGHMBP2 UBB;UBC MACROH2A2 MACROH2A1 MRM2 MACROD1 MACROD2 CMTR1 PAIP1 TOMM70 UPF2 UPF1 AQR SLC6A19 ISG15 PARP14 PARP9 MPP5 GDAP2 APOA1 UBA52 NLRP12 ACE2 TAB1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260910%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB3 CACNA1C CACNA1F ITGB8 ITGAV ITGB7 ITGB6 CACNA1S ITGA4 ITGA3 ITGA2 CTNNB1 DSP ITGA1 JUP ACTG1 CDH2 ATP2A2 GJA1 ITGA8 SGCD SGCA ITGA7 SGCB ITGA6 DAG1 ITGA5 SGCG ACTN3 ACTN1 CACNA2D1 ITGA9 CACNA2D3 CACNA2D2 TCF7 ACTN4 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 PKP2 DSG2 EMD DSC2 CACNG6 SLC8A1 CACNG7 CACNG8 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 ACTB-1 LEF1 TCF7L2 TCF7L1 DMD DES RYR2 LMNA ACTN2 LAMA2 ITGA2B CTNNA1 CTNNA3 CTNNA2 ITGA10 ITGA11 ITGB1 CACNA1D ITGB5 ITGB4 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway SYT11 UBB;UBC UBA1 PINK1 MAPK14 MAPK12 MAPK13 MAPK11 CASP9 CASP3 SNCA SLC6A3 APAF1 CCNE2 CCNE1 PRKN PARK7 HTRA2 TH UBA7 CYCS-1 LRRK2 UBE2L6 UBE2J2 DDC UBE2J1 CASP7 UCHL1 ATXN2 CASP6 CASP2 GPR37 SEPTIN5 UBE2G1 UBE2G2 SNCAIP EPRS1 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260910%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine GCH1 MAOB DNAJC12 COMT PTS QDPR SPR AANAT DHFR2;DHFR TH PNMT MAOA ASMT PAH DBH MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260910%WP2006%HOMO SAPIENS miR targeted genes in squamous cell NRP1 PKM SDCBP PODXL GAS2L1 RHEB VCAM1 GNAI2 FGF2 AP2A1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A YWHAQ UBE2J1 MAP3K8 SLC38A1 TUBA1A CPNE8 VEZT ACAA2 SRPRB-1 ARF4-1 PWP1 DHX57 ARFIP1 CIAO2A HOXA7 POGLUT3 RARS1 ANXA2 TPM3 FNDC3B FBXW11 FNDC3A GOLGA7-1 DHX40 IDH1 RAB34 RAI14 SRSF9 TMED10 CBFB ADIPOR2 MRPL20 COMMD9 ANPEP SLC38A2 ATP6V1C1 ATP6V1F PEDS1-UBE2V1;PEDS1 SLC4A10 TBCA MOV10 NCL-1 HNRNPM CHMP2A ANP32B PICALM TRAM1 ADAR MAGT1 MRC2 SPTLC1 GFPT1 SH3BGRL3 TMED7 POLD2 TMED2-1 ELOVL5 ATRX SIGMAR1 PRPF40A CTDSP1 CSDE1 POM121;POM121C PXDN PTMA PNP-1 MTPN SEC23A TGFBR2 MRPS33 AKAP8 DNAJB1 POLR2C PPP1R7 SH3BP4 RTN4 PDLIM7 MPZL1 SLC12A2 GALNT7 TXNRD1 GALNT1 AP3D1 ARCN1 CUL4B TMEM59 SPCS3 FMNL2 GYS1 ATP6V0E2;ATP6V0E1 NEDD4 PDCD4 LAMTOR5 ATP2A2 BET1 SYNE2 TMEM43 HMOX1 TPM1 HES1 E2F3 HSD17B12 LAMC1 SMAD1 P4HA2 NF2 MET AXL PISD THBS1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260910%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway RACK1 PDGFD COL1A1 HIF1A COL1A2 IL11RA CCN2 PTPN11 AGT RRAS MAS1 MAP2K6 SMAD4 F12 IL6ST TGFBR1-1 JUND SMAD2;SMAD3 RAF1 SP1 IL11 ACE2 AGTR1 ACTA2 TGFB1 NOX4 MAPK1 TGFBR2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260910%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 LIPC PLTP GPIHBP1 GHR EPHX2 PCSK9 APOA1 LDLRAP1 USF1 CETP APOA2 APOB LPL LDLR LCAT PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260910%WP4917%HOMO SAPIENS Proximal tubule transport ABCG2 SLC5A5 SLC6A19 SLC16A10 ATP6V0E2;ATP6V0E1 SLC4A2 SLC4A4 AQP1 CA2 CA4 ATP6V1E1 SLC22A11 SLC13A3 ATP6V1G1 ATP6V0B SLC6A18 SLC36A2 SLC34A1 ATP1B1 SLC5A8 SLC7A8 SLC7A9 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A SLC22A6 SLC47A1 SLC20A2 SLC22A2 SLC1A1 SLC3A1 SLC3A2 ATP1A1 SLC5A2 SLC6A20 CLTRN ATP6V1H ATP6V0A4 ATP6V1D SLC12A4 FXYD2;FXYD6-FXYD2 SLC22A8 ABCB1 SLC22A7 SLC2A1 SLC26A6 SLC2A2 ABCC4 ABCC2 SLC9A3 SLC5A1-1 ATP6V1C1 ATP6V1F SLC7A7 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260910%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies JUNB CREBBP WNT7B CTNNB1 RB1 CDKN1A FNTA CEBPA CEBPB TCF7 SPP1 EMD TMPO LEMD3 CEBPD ACTB-1 AXIN1 LEF1 MAOA E2F1 HES1 HES5 TCF7L2 TCF7L1 CSNK1A1 CTSK APC TLE1 DICER1 RUNX2 BMP2 HMGA2 MAOB TARBP2 AGO2 ICMT CDK4 LMNA NOTCH1 ZMPSTE24 SREBF1 WNT10B TNFRSF11B SMAD2;SMAD3 KAT2B MSTN GSK3B HDAC1 NAP1L1 TGFB2 MYOD1 TGFB1 PPARG HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260910%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GNRH1 SST GHRH IGF1 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260910%WP1434%HOMO SAPIENS Osteopontin signaling ITGB3 MAPK3 SPP1 ITGAV PLAU IKBKB CHUK RELA MMP9 NFKB1 MAP2K2;MAP2K1 MAPK1 MAP3K14 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260910%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ITGB3 ITGB2 MAPK9 ACTC1;ACTG2 SGMS1 LIMD1 MAPK8 ITGB8 STK3 SAV1 ITGB7 YAP1-1 ITGB6 MAP4K5 TEAD1 MAP4K3 WWTR1 TEAD3 MAPK10 MAP4K4 TEAD4 CTNNB1 MAP4K1 MAP4K2 ACTG1 MST1 LATS1 ACTA1 NF2 TEAD2 SRC BUB1B-PAK6;PAK6 PAK1 CDH1 CTNNA1 PAK5 PAK3 PAK2 PAK4 YWHAQ ACTB-1 ACTA2 ITGB1 ITGB5 ITGB4 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260910%WP4331%HOMO SAPIENS Neovascularization processes DLL4 MAPK9 MAPK3 NOTCH3 NOTCH1 MAPK8 NOTCH4 HIF1A SMAD1 ACVRL1 CXCR4 RELA CXCL12 JAG1 MMP9 TGFBR1-1 SMAD2;SMAD3 SMAD9 KITLG SMAD5 KDR FLT4 PDGFB EPHB2 AKT1 EPHB4 ANGPT1 REL RELB TGFB2 KIT TGFB1 TGFB3 NFKB1 MAPK1 NFKB2 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260910%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis MYD88 TRAF6 MAP3K7 MAPK8 MAPK14 ICAM1 IKBKB IKBKG CHUK IL6 IRF1 RELA ELANE GZMH;GZMB-1 TRAF3 CCL3L1;CCL3L3;CCL3;CCL18 NFKBIA LCN2 IL10 CXCL8 CCL4L2;CCL4L1;CCL4 VCAM1 IL1A TLR8 TLR7 TLR4 TNF IRAK1 REL IRF5 RELB IRF7 IRAK4 NFKB1 TAB2 NFKB2 TAB1 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 CUL1 HDAC2 STAT1 PARP1 STAT3 BTRC PARP14 PARP9 STAT6 RBX1 SKP1 DTX3L PARP11 PURINERGIC SIGNALING%WIKIPATHWAYS_20260910%WP4900%HOMO SAPIENS Purinergic signaling LPAR4 GNAI1 GNA11 LPAR6 GNAS-1 ADORA1 GNAZ PANX1 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 P2RY2 ADORA3 P2RY1 GNAI3 GNAT1 GNAI2 P2RY12 P2RY13 P2RY10 P2RY11 P2RY14 ADORA2A P2RX7 P2RX6 GNAO1 P2RX5 P2RX4 P2RX3 ADORA2B P2RX2 P2RX1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway SIKE1 CXCL10 RNF125 TRAF6 MAP3K7 IRF3 IFNE MAPK9 IFNK NFKBIB NLRX1 TKFC DDX3X-1 CYLD MAVS SNW1 MAPK14 STING1 MAPK12 PIN1 MAPK13 TBKBP1 IKBKB ISG15 MAPK10 MAPK11 IKBKG CHUK RELA TRAF2 NFKBIA CXCL8 IFNG TNF IFNB1-4 TANK IRF7 ATG12-1 ATG5 MAPK8 CASP8 TRADD RIPK1 FADD CXCL12 MAP3K1 TRAF3 IFIH1 TBK1 OTUD5 CASP10 DHX58 TRIM25 AZI2 IKBKE NFKB1 DDX17 DDX58 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260910%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3R3 YAP1-1 TEAD1 PLCB3 PKN3 TEAD3 MOB1A;MOB1B PLCB4 TEAD4 LATS2 RHOA PKN2 GNAQ PKN1 PLCB1 LATS1 PLCB2 TEAD2 TRIO ROCK1 TSC2 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR TSC1 PIK3R2 PIK3R1 PTK2 PIK3CA MAPK1 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260910%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling SMAD2;SMAD3 MAPK9 LOXL2 MAPK8 BMPR1A LOXL4 MAPK14 BMPR2 LOXL1 LOX BMP1 SMAD4 TGFB1 GREM1 TGFBR1-1 TGFBR2 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260910%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions ITGB3 ITGAV HTR7 MAPK14 JAK3 ITGA2 IKZF2 LGALS3 LGALS1 CCN3 ROS1 TGM2 NKX6-2 STAT5A STAT5B EBI3 FOXO4 APOD GSDMD AREG MCAM CDC42 TMEM119 HEXB CCR8 CCR6 SSTR2 FAM20C CD47 CX3CR1 CNP SEMA3F AIF1 CCL1 KLRG1 TNF IL33 CCL20 IL10RB GALC MBP CD68 IL1RAP SOX9 CD4 NKX2-2 MOG CXCL2;CXCL3;CXCL1-1 OLIG1 IGF1 OLIG2 MYD88 IL1B PLP1 FOXO1-1 TGFBR1-1 TNFRSF1B CD86 CD274 CD80 IL2RG CTLA4 TGFB2 TGFB1 SOCS3 NFKB1 IL10RA NFKB2 SIRPA;SIRPB1;SIRPG RAC1 TGFBR2 IL2RA IL2RB PDCD1 JAK1 STAT1 STAT3 TYK2 IL6 IGF1R MMP9 IL10 OSM PDGFA IL18 NOS2 IL2 IL4 SPP1 IFNG PDGFRA IL12A TLR4 EGFR CASP1 NLRP3 VEGFA CD28 CD44 CXCL12 STAT4 SMAD2;SMAD3 IL12RB1 IL12RB2 FOXP3 P2RY12 FOXO3 TGFBR3 NKX6-1 CSPG4 PTK2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260910%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor SMAD2;SMAD3 RHO MAPK9 COL1A1 MAPK8 STAT3 MAPK10 CCN2 ENPP2 ACTA2 TGFB2 TGFB1 TGFB3 FN1 WNT SIGNALING%WIKIPATHWAYS_20260910%WP428%HOMO SAPIENS Wnt signaling MAPK9 WNT11 WNT7B CTNNB1 CCND3 CCND2 ROCK2 FOSL1 CCND1 MYC DKK2 DKK4 PPP3R1 SOX17 CER1 SERPINF1 CTNNBIP1 SFRP1 SFRP2 DAAM1 DAAM2 SFRP5 CTBP2 CTBP1 PORCN VANGL1 RYK-1 VANGL2 INVS KREMEN1 ROR1 SENP2 ROR2 PRICKLE2 PRICKLE1 PPP3CA CXXC4 PPP3CB NKD1 NKD2 PPP3CC WIF1 MAPK8 GPC4 NOTUM PLCB3 PLCB4 PLCB1 PLCB2 JUN FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 GSK3B NLK RAC1 MAP3K7 DKK1 SOST PLAU TPTEP2-CSNK1E;CSNK1E FRAT2 CSNK2A2 SFRP4 CSNK2B TCF7 DVL1 DVL2 DVL3 FZD10 AXIN1 CSNK2A1;CSNK2A3 LEF1 PRKCG NFATC3 TCF7L2 NFATC4 TCF7L1 WNT5B CSNK1A1 PRKCB APC PRKCA CAMK2B CAMK2D CAMK2A WNT6 WNT1 NFATC2 CAMK2G WNT2 RHOA WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 NFATC1 CHD8 WNT2B WNT16 LRP5 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes NR1H3 CYP7A1 IDI1 EBP CYP51A1 MVK NSDHL IDI2 SC5D MSMO1 DHCR24 HSD17B7 ACAT2 LBR TM7SF2 HMGCS1-1 PMVK SREBF1 ACOT2;ACOT1 FDFT1 MYLIP FDPS GGPS1 NR1H2 ELOVL3 ACSL3 LSS PLPP6 CH25H ABCG1 ABCA1 HMGCS2 CYP46A1 FADS2 ACSL1 SCD ELOVL4 MVD HMGCR ELOVL2 ELOVL5 CYP27A1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260910%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA9 DMAC2L ATP5PF NDUFA8 NDUFA7 NDUFA6 ATP5PD NDUFA5 NDUFA4 ATP5PB NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 GZMH;GZMB-1 NDUFA11 NDUFA10 ATP6AP1 ATP6AP2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFA4L2 NDUFB2 ATP5MC2 NDUFB1 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5ME COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases IDH2 D2HGDH MDH2 L2HGDH ADHFE1 ALDH7A1 ACY1;ABHD14A-ACY1 GCDH DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260910%WP2289%HOMO SAPIENS Drug induction of bile acid pathway SLC51A SLC51B CYP7A1 VDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 ABCC4 SLC10A1 ABCC2 NR1I3 NR1I2 NR1H4 BAAT ABCB11 SULT2A1-4 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 IL5 SIGNALING%WIKIPATHWAYS_20260910%WP127%HOMO SAPIENS IL5 signaling JAK2 RPS6KB2 MAPK3 JAK1 STAT1 STAT3 ELK1 PTPN11 RPS6KA1 MAPT RPS6KB1 KRAS GRB2 IL5RA CSF2RB JUN LYN SOS1 STAT5A STAT5B SYK BTK SHC1-1 SPRED1 RAF1 IL2 FOXO3 AKT1 PIK3CG GSK3B PIK3R2 RPS6 PIK3R1 GSK3A MAP2K2;MAP2K1 MAPK1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260910%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome C3-1 LMNB1 FNTA ICMT LMNA C5 LMNB2 RCE1 CFB CFD GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2276%HOMO SAPIENS Glial cell differentiation MSN MBP MAG TPPP PLP1 CNP GAP43 ALSTROM SYNDROME%WIKIPATHWAYS_20260910%WP5202%HOMO SAPIENS Alstrom syndrome DNM3 SMO VCP-1 RABL2A;RABL2B TFDP2 PTCH1 ACTN4 E2F4-1 IFT172 BLOC1S4 VCPIP1 HSPB11 IFT74 BLOC1S6 BLOC1S1 STX5 CEP192 SNAPIN PIFO IFT81 RFX2 IFT27 DTNBP1 RFX3 RFX1 TUBG1 ARMCX5-GPRASP2;GPRASP2 NSFL1C CEP19 RILPL1 MYO5B GPR161 ALMS1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2406%HOMO SAPIENS Cardiac progenitor differentiation DKK1 MAPK14 GATA4 KDR PDGFRA FGF2 SOX17 PAX6 MESP2 MESP1 MYLK3 KIT SCN5A MEF2C NRG1 SOX1 ISL1 IGF1 TNNT2 MYL2 ZFP42 MYH6 BMP4 POU5F1;POU5F1B ROR2 THY1 TBXT TBX20 TNNI3 ACTC1;ACTG2 NKX2-5 NOTCH1 IRX4 IGF2 TBX5 LIN28B NANOG;NANOGP8 LIN28A MIXL1 NODAL SOX2 BMP1 CXCR4 INS;INS-IGF2 ANPEP FOXA2 WNT3A NOG INHBA GSK3B NCAM1 TGFB1 SIRPA;SIRPB1;SIRPG NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260910%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging SIRT1 SIRT3 NAMPT FOXO1-1 HIF1A ROS1 PPARG PARP1 FOXO3 NFKB1 TFAM-1 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260910%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 EXOC8 RALBP1-1 RALA-1 YBX3 EXOC2 KRAS RAC3 NRAS HRAS RAC1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260910%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS ITGB3 ILK DKK1 ITGAV PODXL ITGA3 CTNNB1 CDKN1A CDKN1B CDH2 CDKN1C PLAUR DAG1 ACTN4 VIM TLR4 COL4A4 YWHAQ CR1L;CR1 PAX2 VTN DNM1 CAMK2B NPHS1 NOTCH1 NPHS2 WT1 MME PLCG1 WNT1 SCARB2 SMARCAL1 PTPRO MKI67 CLDN1 LAMA5 JAG1 SYNPO NCK1 KIRREL3 CTSV;CTSL TRPC6 KIRREL2 KRT8 CD2AP INF2 COL4A3 COL4A5 MYH9 IRF6 LMX1B UTRN CD151 LAMB2 PARVA FYN MYO1E LRP6 LIMS4;LIMS1 TLN1 FAT1 VCL AGRN AKT1 CD80 PCNA PLCE1 PTK2 TGFB1 ITGB1 LRP5 ITGB4 MRNA PROCESSING%WIKIPATHWAYS_20260910%WP411%HOMO SAPIENS mRNA processing XRN2 SRSF2 SRSF3 CD2BP2 SNRPF SREK1 SRSF5 SRSF6 HNRNPU SRSF7 SNRPA SNRPB DHX8 CSTF3 DDX1 CSTF2 SNU13 METTL3 PRPF8 PCBP2 DHX38 SNRPE-2 CPSF4 CPSF1 FUS DHX9 CPSF3 CLK4 CLK3 LSM2 CLK2 SRPK1 HNRNPL CLK1 LSM7 HNRNPK RNPS1 CLASRP HNRNPC HNRNPD SUGP2 SUGP1 SMC1A CELF1 CELF2 CELF4 SRP54 YBX1 PTBP1 SNRNP70 DHX15 DHX16 RBM5 CPSF2-1 RBM17 PRMT2 PRMT1 PTBP2 PRPF18 HNRNPH1 HNRNPH2 SNRPA1 DNAJC8 HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 SFSWAP RNMT SRSF1 DDX20 CSTF2T PPM1G NXF1 POLR2A U2AF2 TRA2B SPOP SNRPB2 SNRPG-2 SF3B1 SRSF10 SF3A3 RBM39 SF3A1 SRSF4-1 RNGTT SF3A2 HNRNPAB NUDT21 SNRNP40 PHF5A HNRNPA2B1 PABPN1-1 SRSF9 RBMX TMED10 HNRNPM NONO PRPF40A SFPQ-1 SUPT5H NCBP1 DICER1 NCBP2-1 U2AF1L5;U2AF1 HNRNPR EFTUD2 SNRPD2 CLP1 SNRPD1 PAPOLA SNRPD3 SRPK2 TXNL4A PSKH1 SNRPN PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism APOA4 IDI1 EBP CD36 CYP51A1 MVK NSDHL SC5D MSMO1 DHCR24 HSD17B7 DHCR7 ACAT2 LBR TM7SF2 HMGCS1-1 PMVK FDFT1 APOA1 MTTP FDPS SAR1B LSS NPC1L1 MGAT1 APOB LDLR ABCG8 ABCA1 ABCG5 FABP2 SQLE SLC27A4 DGAT1 MVD HMGCR STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260910%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling SCARB1 PRKAA1 FGF21 PRKAA2 PRKAG1 PRKAG2 PRKAG3 LDLR PRKAB2 PRKAB1 ACLY SP1 CREB1 ATF6 GSK3A IDI1 CYP51A1 SIRT1 HMGCS1-1 SREBF1 FDFT1 FDPS NR1H2 ACACA LPIN1 INS;INS-IGF2 LSS SAR1B FASN GPAM PPARGC1B SQLE MED15 YY1 SEC13 PRKACA-1 SREBF2 RBP4 KPNB1 SCD SAR1A INSIG2 INSIG1 RNF139 SCAP ACSS1 SEC23B AKT1 SEC31B MVD SEC31A MTOR CAMP HMGCR MBTPS1 SEC24B SEC24A MDH1 AMFR SEC24D-1 CDK8 NFYA-1 PIK3CA SEC24C MBTPS2 PPARG SEC23A LPL TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260910%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 INSR CACNA1A MAPK8 SLC2A2 PRKCZ TNF PIK3R5 IKBKB MAFA MTOR GK IRS1 ADIPOQ INS;INS-IGF2 SURF1 KCNJ11 PDX1 PHKA2 MAPK1 SOCS4 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260910%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PC HLCS PCCB MCCC2 MCCC1 ACACA ACACB BTD PCCA ERBB SIGNALING%WIKIPATHWAYS_20260910%WP673%HOMO SAPIENS ErbB signaling EIF4EBP1 CBLB NCK2 MAPK9 NRG2 MAPK3 EREG BTC MAP2K4 NRG3 NRG4 PLCG2 HBEGF ERBB3 BAD ERBB4 ABL2 ELK1 GAB1 PDPK1 MAPK10 CDKN1A CDKN1B RPS6KB1 CBL GRB2 SOS1 CRK STAT5A STAT5B SHC4 EGF SHC1-1 SHC2 AREG SRC CCND1 TGFA PAK1 MYC ERBB2 PAK3 PAK2 PAK4 TP53 MDM2-2 SOS2 EGFR ABL1 PRKCG NRG1 PRKCB PRKCA RPS6KB2 CAMK2B CAMK2D NRAS MAPK8 CAMK2A PIK3R3 HRAS CAMK2G MAP2K7 KRAS FOXO1-1 JUN NCK1 CRKL BUB1B-PAK6;PAK6 RAF1 ARAF PAK5 PIK3CD AKT2 BCL2L11 AKT3 PIK3CB AKT1 SHC3 MTOR GSK3B PIK3R2 BRAF PIK3CA PIK3R1 PTK2 MAP2K2;MAP2K1 MAPK1 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP3K7 MAPK9 MAPK3 MAP2K4 MAPK8 MAPK14 PARP1 MAPK12 TNKS MAPK13 MAP3K21 MAPK10 DUSP1 PARP14 MAPK11 MAP3K12 MAP3K9 MAP2K7 MAP2K6 MAP2K3 MAP3K1 MAP3K10 RAF1 MAP3K11 ARAF ATF4 MAP3K5 MAP3K8 BRAF MAP2K2;MAP2K1 MAPK1 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260910%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism SLC2A4 PYY GCG FFAR2 FFAR3;GPR42 PPARD ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260910%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway IRF3 IL1B RXRA GUCY1B1 IKBKB MMP1 KEAP1 IKBKG CHUK SLC7A11 IL6 GUCY1A2 GUCY1A1 RELA MMP3 NFKBIA GCLC CXCL8 GSTA3;GSTA5;GSTA1;GSTA2 TMPRSS2 GCLM HMOX1 NQO1 IL12A PRKG2 TNF NFE2L2 CCL13;CCL2 ACE2 NFKB1 NOX1 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260910%WP5124%HOMO SAPIENS Alzheimer 39 s disease ITPR2 GAPDH-1 HSD17B10 IKBKB CHUK RELA APP CALML6 CALML3 CALML4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 ATG14 PSMC2-1 ATG13 DKK2 DKK4 VDAC3 ULK2 ULK1 VDAC1 ATF6 TNF ATF4 APH1A NCSTN GRIN2A PPP3R1 AXIN2 APH1B NRBF2 XBP1 EIF2AK3 EIF2AK2 GRIN2C GRIN2B GRIN2D ATG2A NOX4 CALM1 CALM2 NOX1 ATG2B IDE SLC25A4 RYR3 TUBA1C IL1B PPP3CA PPP3CB TUBA1A PPP3CC PSENEN MAPK8 MME BACE1 CASP8 PSMA5 PSMA6 PLCB3 PSMA3 PLCB4 FADD PSMA4 PSMA1 MAPT TNFRSF1A PLCB1 PLCB2 MAP2K7 TUBB3;TUBB6 PSMA7 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 DDIT3 PSMB2 PSMB3 PSMB1 APBB1 TUBB4B RAF1 CALM3;CALM1 GRIN1 FZD1 PSMA2-1 PSMC5 FZD3 PSMC6 PSMC3 WNT3A PSMC4 WNT5A WNT7A PSMC1 CDK5R1 IRS4 VDAC2-1 WNT3 KIF5C LRP6 AKT2 KIF5B AKT3 KIF5A AKT1 TUBB1 MAP3K5 MTOR CYBB TUBA4A ERN1 ADAM17 PPIF PPID GSK3B RTN3 PIK3R2 PSMD12 PIK3R1 PSMD14 PSMD13 PSEN2 ITPR1 MAP2K2;MAP2K1 CACNA1D GPR83 MAPK1 ITPR3 CACNA1C PSEN1 CACNA1F KLC1 AGER MAPK3 DKK1 RTN4 KLC4 KLC3 KLC2 ATG101 NAE1 BAD CACNA1S TUBA3E;TUBA3C-1 EIF2S1 SEM1 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E MCU TUBA8 ATP2A3 IL6 ATP2A2 ATP2A1 FRAT2 RB1CC1 TUBB2B;TUBB2A TRAF2 CSNK2A2 WIPI1 SFRP4 WIPI2 CSNK2B SLC25A5 SLC25A6 BECN1 TUBAL3 DVL1 BECN2 DVL2 AMBRA1 SNCA DVL3 NOS2 ADRM1 SLC25A31 IL1A FZD10 APC2 AXIN1 CSNK2A1;CSNK2A3 CSNK1A1 WNT5B APC PIK3R4 PIK3R3 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 ARAF CAPN2 CAPN1 WNT2B PIK3CD PIK3CB BRAF WNT16 PIK3CA PIK3C3 LRP5 MAPK9 WNT11 WNT7B MAPK10 CTNNB1 CASP9 CASP3 APAF1 CYCS-1 BID CDK5 FAS IRS1 IRS2 INS;INS-IGF2 CHRNA7;CHRFAM7A NOS1 NFKB1 APOE INSR CSF1 CASP7 ADAM10 NRAS HRAS GNAQ KRAS PTGS2-2 LRP1 LPL NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260910%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease MAPK9 PRKAA1 RXRA IKBKB UQCRB UQCR11 CEBPA UQCR10 BBC3 RELA UQCRQ PRKAA2 UQCRC1 PRKAG1 PRKAG2 UQCRFS1 CYC1 UQCRC2 PRKAG3 CASP3 CDC42 PRKAB2 PRKAB1 VCAM1 TNF ATF4 CYCS-1 PPARA XBP1 EIF2AK3 BID GSK3A IL1B NR1H3 MAPK8 CASP8 FAS BAX SREBF1 TNFRSF1A IRS1 IRS2 ADIPOQ LEPR JUN INS;INS-IGF2 ADIPOR1 DDIT3 ADIPOR2 NDUFA11 NDUFA10 NDUFA13 MAP3K11 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB9 NDUFB8 AKT2 NDUFB7 AKT3 NDUFB10 AKT1 NDUFB6 MAP3K5 NDUFB5 CCL13;CCL2 NDUFB4 NDUFA4L2 ERN1 NDUFB2 NDUFB1 GSK3B CYP2E1 PIK3R2 PIK3R1 NDUFC2;NDUFC2-KCTD14 TGFB1 NDUFV3 SOCS3 NDUFV2 NFKB1 NDUFV1 RAC1 NDUFA9 IL6R NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 NDUFAB1 EIF2S1 NDUFS5-1 LEP NDUFA12 IL6 COX6A1 COX6A2 NR1H4 SDHC SDHD TRAF2 SDHA COX6B2 SDHB COX6B1 NDUFB11 COX7A2 COX7B2 CXCL8 COX7B COX4I1 INSR COX4I2 COX7C MLX COX8A COX8C IL1A COX7A2L-1 NDUFB3 COX5B COX5A MLXIP SMAD7 PKLR COX6C ITCH CASP7 BAK1 PIK3R3 BCL2L11 PIK3CD PIK3CB FASLG PIK3CA JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260910%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells SOCS2 JAK2 IL6R CDK4 NRAS STAT1 HRAS STAT3 GHR IL6 KRAS CCND3 CCND2 STAT5A STAT5B EPO RPTOR IFNGR1 IFNGR2 IFNG MLST8 AKT2 EPOR AKT3 AKT1 MTOR PRL SOCS1 CISH PRLR FOXM1 SOCS3 AKT1S1 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260910%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease RAF1 MAPK3 CREB1 RPS6KA5 GRM1 HRAS ELK1 HTT EGFR CASP7 NTRK2 BDNF EGF MAP2K2;MAP2K1 CASP3 MAPK1 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260910%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis GNA13 GNA12 RHOA ARHGEF1 TBXAS1 TBXA2R PTGS1 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260910%WP259%HOMO SAPIENS Nifedipine activity PTK2B PCNA SOD1 KDR BDKRB2 MAP2K2;MAP2K1 MAPK1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260910%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia MYC ABCG2 PDGFRA PDGFRB FOXO3 CSF1R GAB2 CDKN1B NOP2 BCR ABL1 SPRED2 PIM2 KIT SKP2 FLT1 PIM1 GADD45A ABCB1 LYL1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADM HADH ACADS EHHADH-1 ACSL1 SCP2 CPT1A PECR ACADVL ECI1 ACSL3 ACSL4 ACSF2 HADHA ACADL CPT2 SLC25A20 FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260910%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 APOA5 LMF1 LIPC APOC2 PLTP GPIHBP1 APOA1 CETP LRP1 SEL1L APOA2 LPL LDLR LCAT CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260910%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism JAK2 TRAF6 DKK1 SP7 SOST ATG101 LEP IL6 RB1CC1 CLOCK TNFSF11 PRKAA2 CALCA BECN1 NR1D2 AMBRA1 ATG13 HMGB1-1 BHLHE41 ULK1 LAMP2 IL3 CSF1 SERPINF1 ATG3 MAP1LC3B2;MAP1LC3B-1 ATG10 ARNTL ATG12-1 SQSTM1 IGF1 ATG7 CTSK ATG5 BMP4 RUNX2 BMP2 ATG16L1 ARHGAP4 FYCO1 MEPE ATG4C NOTCH1 CTF1 PER1 SEMA3A CHRD EFNB2 DRAM2 CTHRC1 TRAP1 VCP-1 SEMA4D RORB BMP5 BMP3 PLEKHM1 BMP6 WNT10B SMAD1 SMAD4 BCL2 TNFRSF11B SMAD9 SMAD5 TNFRSF11A NPAS2 NFATC1 WNT5A BMPR2 AKT1 MTOR MAP1LC3A BHLHE40 WNT16 PTH TGFB1 PIK3C3 LRP5 CRY1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260910%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway SLC2A1 PDHA1 PRKAB1 LDHA PRKAA1 HIF1A PDK1 TP53 NFE2L2 KEAP1 CUL3 SLC11A2 RPS6 VEGFA PDHB ACACA PRKAG1 ACACB EGLN1 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260910%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer ERBB3 VAV3 CDKN1A PKN1 CDKN1B RPS6KB1 APP JUND APOE CUL1 PAK2 VIM F2R SMAD7 TNF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A AXIN1 HSPD1 PTK2B ABL1 CASP7 NRG1 SQSTM1 IL7R YBX3 SERBP1-1 IER3 HELLS TRAF1 CARD14 TNFRSF21 BEX3 ETS1 CUL5 RNF7 NET1 GCLC BCL3 CTNNA1 BIRC5 NQO1 ANXA5 RIPK2 AKT1 HSPB1 ERN1 THBS1 HDAC1 HSPA5 PTK2 SOCS3 NFKB1 MAPK1 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260910%WP5546%HOMO SAPIENS 22q11 2 distal CNV UBA6 CUL2 CABP1 AK8 SNRPF CD79B CD79A SDF2L1 CWC15 TDRD3 RPS29 SNRPB SNW1 RPS20 HYOU1 AQR RPS21 RPS24 RPS23 ELOC-1 PRPF8 IQUB ELOB ARIH1 SNRPE-2 TOP3B CCDC116 BUD31 NME5 CBL PLRG1 YDJC CANX RBM22 LRP4 RSPH9 PPM1F RNF113A CHEK1 RPS15A RPS3 PAK1 PRAME RPS2 RILP UGGT1 PAK2 PPIL2 CDC5L RSPH3 XAB2 YPEL1 FAU CAMK1 PPIL4 ATF6 CDC16 PPIL6 DHX16 TP53 MDM2-2 SOX9 XBP1 RBX1 SNRPA1 SF3B4 SF3B5 SF3B2 SF3B3 RPS27A UBA1 SNRPB2 SNRPG-2 SF3B1 UBE3A SF3A3 SF3A1 SF3A2 SNRNP40 PHF5A RPS6 HSPA5 CALR-1 PPIB MAPK1 DNAJB11 RACK1 NEDD4 PRKN BCR HSP90B1 CAMK2A RNF19B GNAZ PPIL1-1 RPS15 RPS14 RPS17 VPREB1 RPS16 PTPA RPS19 RPS18 CWC22 ROPN1L RPS11 RPS10 RPS13 CAMK4 RPS12 RSPH6A SRRM2 PDIA2 EFTUD2 RPS9 SNRPD2 ZNF280D;ZNF280A RPS7 SNRPD1 RPS8 RPS5 SNRPD3 DNAJB13 RPSA CRNKL1 PDIA4 IGLL5;IGLL1 RAB36 ERP29 PPIE DYDC1 SNRNP200 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260910%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260910%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER3 CYP19A1 MAPK3 NRAS HRAS PLA1A MMP1 KRAS PTGS2-2 ESR1 SRC PIK3CD AKT2 AKT3 PTGES2 PIK3CB AKT1 PTGER4 PIK3CG PTGER2 EGFR BRAF PIK3CA MAPK1 PTGER1 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260910%WP3645%HOMO SAPIENS NAD biosynthetic pathways IDO1 PARP1 TNKS SIRT4 PARP4 SIRT5 NADSYN1 SIRT1 BST1 SIRT2 TNKS2 SIRT3 NAPRT SIRT6 NMNAT1 NAMPT QPRT CD38 ACMSD TDO2 PARP2 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260910%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR2A IL1B NEK7 RAPGEF3 PRKAR1B PRKAR1A NLRP3 PRKACB-1 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260910%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC1A1 SLC3A1 SLC36A2 SLC3A2 SLC6A20 CLTRN SLC7A7 SLC7A9 SLC6A19 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260910%WP3924%HOMO SAPIENS Hfe effect on hepcidin production BMP6 HFE HJV ID1 TMPRSS6 HAMP SMAD7 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260910%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A1 FGFR4 MAPK3 CYP7A1 ABCB11 FXR1-1 FGF19 SLC10A2 ABCG8 MAPK1 LDLR ABCG5 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260910%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CCR2 CTCF MSMP SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260910%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H4C6 UBE2C MAPK3 MAPK7 STAT3 CDKN1A CDKN1B FOS IL6 UBA52 CDC23 CDC27 RELA ANAPC7 CCNA1 ANAPC4 ANAPC5 CEBPB ANAPC1 CXCL8 ANAPC2 ANAPC10 ANAPC11 IL1A CDKN2D CDKN2B CDKN2C CDC16 CCNA2-1 H2BC21 FZR1 EHMT2 UBE2D1 EHMT1 H2AC14 CDC26 RPS27A H3-3A UBB;UBC H2AC4 CDK6 H2AZ2;H2AZ1 H2AJ ANAPC15 CDK4 ANAPC16 CDK2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC5 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 UBE2S H2AC20 H2AB2;H2AB3;H2AB1 RPS6KA3 RPS6KA2 RPS6KA1 JUN IGFBP7 H4-16 CDKN2A UBE2E1 NFKB1 MAPK1 H4C1 ATM SIGNALING%WIKIPATHWAYS_20260910%WP2516%HOMO SAPIENS ATM signaling RAD50 MAPK9 RAD51 CDK2 CDK1 ATF2 ATM MDC1 RIPK1 RAD9A TP53BP1 IKBKG CRADD CDKN1A MDM4 MRE11 BRCA1 PIDD1 JUN CHEK2 CHEK1 TLK1 NBN SMC1A CDC25C CDC25A CREB1 CCNE1 TP53 MDM2-2 TP73 CCNB1 ABL1 CASP2 BID GADD45A POLYOL PATHWAY%WIKIPATHWAYS_20260910%WP690%HOMO SAPIENS Polyol pathway KHK ALDOB AKR1B1 SORD 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome ABCC6 DCTN6 PLAG1 DCTN4 ACTR1A ACTR1B PLAGL1 KIAA0753 MYH11 BMERB1 DCP2-1 DISC1 OFD1-1 ABCC1 NDE1 MARF1 DCP1A CEP20 ACTR10 PAFAH1B1 DCTN1 RAPGEF4 PLK1 GATA3 RAP1A VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260910%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism SCARB1 RXRA CD36 CYP26A1 ADH4 ADH1C;ADH1B;ADH1A ALDH1A1 RPE65 SDR16C5 RDH12 NPC1L1 RXRB AWAT2 CYP26B1 ABCG8 ABCG5 LRAT RXRG BCO1 RBP4 RARG CRABP2 RDH8 DGAT1 RETSAT CRABP1 RLBP1 RDH10 BCO2 DHRS3 ALDH1A3 RBP7 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 RBP2 RBP1 SULT2B1 RARA RARB RDH5 ALDH1A2 CYP2E1 LPL MAPK1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260910%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome BBS4 NDC1 NUP214 NUP210 NUP133 NIPA1 TACR3 NIPA2 SNURF NUP93 NUP50 FEZ1 FEZ2 NUP54 NUP98 OCA2 NUP205 SLC45A2 RB1 SEH1L NUP58-2 POMC DLX5 TUBGCP2 FSHB ATP10A AAAS LHB NUP160 NHLH2 NUP85 NUP42 CCND2 TPR NDN NUP43 NUP88 CGA MSX1 RAE1 CCND1 RANBP2 NUP155 NUP153 TYR GNRH1 OXT-1 KISS1 TUBGCP5 NUP35 MKRN3 CDC6 TUBGCP6 TUBGCP3 CDKN2B TUBGCP4 CDKN2C NUP37 TP53 MDM2-2 GABRB3 E2F1 GABRG3;GABRG2 GABRD CDK6 CYFIP1 GABRA5 CDK4 RNF8 FMR1 GABRG1 GHRH GHRL PRKCZ UBE3A MDM4 NGF EIF4E UBE2N BDNF INS;INS-IGF2 MAGEL2 SEC13 PCSK1 CDKN2A NUP107 NUP188 SNRPN POM121;POM121C AHCTF1 GLE1 GABRR3 GABRR2 GABRR1 HERC2 NUP62 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GNT5 B3GALT1 B4GALT3 ARSA GBA GALC GBA2 UGT8 UGCG NEU3 NEU4 GAL3ST1 ST3GAL5 B4GALNT1 A4GALT B4GALT6 A3GALT2 GLA B4GALT4 B4GALT5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260910%WP4549%HOMO SAPIENS Fragile X syndrome CPT1A RHEB APP DAG1 HOMER1 SRC PRKAR1A CREB1 CLTC CAMK1 CLTA AP2A1 KCND2 GRIN2A AP2M1 MKNK1 GRIN2B DNM1 DNM2 AP2B1 ALDH5A1 PPP3CA GAD1 PPP1CA ABAT GRM5 CLTCL1 AP2S1 PLCB1 EIF4E BDNF RAF1 SLC6A1 GRIN1 TSC2 FYN AKT1 MTOR ITPR1 MAP2K2;MAP2K1 AGAP2 MAPK1 MECP2 GAB1 PTPN11 RPS6KB1 GRB2 MMP9 SOS1 SHC1-1 PTEN MAP1LC3B2;MAP1LC3B-1 GABRB2 GPHN GABRG3;GABRG2 GABRD CYFIP2 EIF4A1 SH3GL3 PRKCA GABRA1 GRIP1 DICER1 DEPTOR SH3GL1 CAMK2B TARBP2 CYFIP1 EPHA4 GRIA1 AGO2 GRIP2 EEF1A1 ALDH3A2 FMR1 TBC1D7;TBC1D7-LOC100130357 HOXB8 PLCG1 CAMK2A TELO2 GRIA2 RAP1GAP GRM1 EIF4EBP2 SLC16A1 SYNGAP1 ARHGAP32 NF1 EIF4G1 PPP2R5B ABCD3 KCNC1 TECR ARC CLTB DLGAP3 DUSP3 SHANK1 KRAS TTI1 PICK1 DLG4 AKAP5 CNR1 EPS8L1 PTPN5 HCN1 ARAF RPTOR PRKACA-1 MLST8 PDK1 CAMK4 MAP1B PIK3CB TSC1 NTRK2 CDKN2A BRAF AKT1S1 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation VLDLR PAFAH1B3 PAFAH1B2 NDEL1 PAFAH1B1 TUBA1A CLIP1 DYNC1H1 RELN NUDC DCX METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260910%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260910%WP4521%HOMO SAPIENS Glycosylation and related congenital defects DPAGT1 ALG8 ALG9 B4GALT1 ALG6 TUSC3 MPI PMM2 SRD5A3 ALG2 MAGT1 ALG14 ALG3 DOLK MOGS ALG12 ALG1 ALG11 DPM1 GMPPB DPM3 MGAT2 MPDU1 DPM2 JOUBERT SYNDROME%WIKIPATHWAYS_20260910%WP4656%HOMO SAPIENS Joubert syndrome TCTN2 BBS4 CSPP1 TCTN1 BBS9 BBS7 CEP97 CEP290 CC2D2A BBS5 ARMC9 RPGRIP1L TMEM138 RP2 TMEM216 ANKS6 CEP104 ARL3 ARL2 RAB8A ARL13B TMEM67 MRE11 INPP5E RHEB NPHP1 MYO6 PDE6D NPHP3 FLNA PDE6B PDE6A AHI1 PCNT PIBF1 NEK8 BBS2 DVL1 BBS1 RAB3IP MYO5A MKS1 DVL3 CPLANE1 TMEM231 NIN TTC8 TMEM17 KIAA0586 TMEM237 UNC119 B9D1 CEP41 B9D2 ATF4 SHH INVS RAD50 PARP1 ATM RHOA CETN2 OFD1-1 MTOR ZNF423 CETN1 CEP120 CEP164 CCP110 ARR3 KAT5 TCTN3 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260910%WP2328%HOMO SAPIENS Allograft rejection C3-1 IL2RA C1QC PRF1 STAT1 IL12B LOC110384692;C4A;C4B_2;C4B IL13 CASP9 CSNK2A2 CASP3 IL10 C5 CXCL8 C1QB IL2 IL4 IL1A VIM IFNG C2 CD40LG PDGFRA IL12A C6 C7 C9 HLA-DPB1-1 TNF CD55 IL5 CXCL13 C8B C8A HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCL9 HLA-DOA LRRK2 HLA-DOB GABPA HLA-DPA1 HLA-DRA BHMT2 CASP7 CXCR5 HLA-DQB2;HLA-DQB1 PECR HLA-DMB VEGFA CCL19 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD28 HARS1 CCL21 COL5A1 CXCL11 ABCB1 IL17A IL1B GDNF CASP8 FAS PRKCZ IL21 IL22 CXCL12 GZMH;GZMB-1 HLA-DMA CD40 FOXP3 CD86 CD80 FASLG AGTR1 CTLA4 TGFB1 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260910%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway EIF4EBP1 MAPK9 MAPK3 BAD MAPK14 STAT3 MAPK12 MAPK13 IKBKB PTPN11 MAPK11 CTNNB1 IKBKG CHUK DOK2 MMP2 RELA GRB2 CASP9 SOS1 CRK STAT5A STAT5B NFKBIA FN1 SRC PAK1 MYC NOS2 ERBB2 TP53 EGFR CASP7 MSH2 RS1 TNIP3-2 RASA1 ANGPTL1 GRB14-1 GRB7 RAD51 TIE1 TNIP1 TNIP2 NRAS MAPK8 YAP1-1 BAX HRAS KRAS FOXO1-1 NCK1 STMN1 NOS1 BIRC5 ANGPT4 AKT1 PXN ANGPT2 ANGPT1 TEK PIK3CA PIK3R1 PTK2 ITGB1 NFKB1 MAPK1 RAC1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260910%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HPSE2 IDUA HEXA GLB1 GNS SGSH GALNS HYAL1 HYAL2 HYAL4 IDS NAGLU HPSE GUSB ARSB IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260910%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL6 BLVRB JAK1 IL1A STAT2 HMOX1 BLVRA STAT1 STAT3 IL10 IL10RA IL10RB NUCLEAR RECEPTORS%WIKIPATHWAYS_20260910%WP170%HOMO SAPIENS Nuclear receptors ROR1 NR1H3 RXRA AR NR2C2 VDR PPARD NR5A1 NR2F6 NR1I3 NR1I2 NR2F2 NR2E1 NR3C1 NR1H2 RORC ESRRA RORA ESRRB NR2F1 THRB NR0B1 THRA RXRB NR4A2 ESR1 NR4A1 NR1D2 NR5A2 RXRG HNF4A ESR2 PGR RARG RARA PPARA RARB PPARG CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260910%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis ITPRIP CABIN1 LCK CD8A HDAC2 PPP3CA CD8B;CD8B2 PPP3CB MEF2D PPP3CC CAPN2 PLCG1 EP300 NFATC2 CD4 ATP2A1 HDAC1 ZAP70 CALM1 NR4A1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members DVL2 CUL1 DVL3 TNK2 TNK1 PLK1 PARP10 PARP1 BTRC CTNNB1 AXIN1 RBX1 SKP1 APC DVL1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260910%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CUL2 ELOB RBX1 ZYG11B UBA3 NAE1 CBFB ELOC-1 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260910%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL1B IL12B ZBTB16 IL6 IL22 IL13 RORC RORA IL25 TBX21 AREG IL18 IL9 IL4 IFNG IL23A ID2-1 IL12A GFI1 EOMES TNF IL33 TSLP IL5 BCL11B GATA3 IL15 TOX HNF1A IL7 AHR NFIL3 IL17A FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260910%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 APOA5 LMF1 LIPC APOC2 DGAT2 PLTP GPIHBP1 FAS ACSS1 PDIA2 GCK APOA1 MTTP CETP LRP1 SEL1L GCKR APOA2 LPL LDLR LCAT EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260910%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR3B POLR1A ILK POLR2C ERCC3 POLR3D POLR1B POLR3E POLR1D POLR2A TAF7 POLR1E TAF6 ERCC2 POLR3H TAF5 POLR3K CDK7 MNAT1 GTF2H2C;GTF2H2C_2;GTF2H2 GTF2A2 CCNH GTF2B TAF9 GTF2E1 GTF2E2 POLR2B POLR2E POLR2F POLR2G POLR2H POLR2I TBP GTF2H1 TAF12 GTF2H3 TAF13 GTF2F2 GTF2H4 POLR2J;POLR2J2;POLR2J3 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP5414%HOMO SAPIENS IDO metabolic pathway IDO1 GOT2-1 IFNG AADAT KMO TDO2 KYNU KYAT3 TNF KYAT1 IDO2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260910%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2A13;CYP2A6;CYP2A7-1 CYP2D6;LOC107987479;LOC107987478-1 FMO1 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 FMO3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A1 CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2A1-4 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260910%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex LCK CD8A CD8B;CD8B2 FYN CD3G PRG3 CD3E CD2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 NKRF CD247 CD4 LBP MMP25 IL6 HLA-DRA CRP IGLL5;IGLL1 ZAP70 CXCL8 KALLMANN SYNDROME%WIKIPATHWAYS_20260910%WP5074%HOMO SAPIENS Kallmann syndrome GNRH1 MYRF FGFR1 CHD7 ASCL1 PROK2 PTPN11 AKT1 PLXND1 FRS2 SEMA3E ANOS1-1 TMEM98 OTX2 LHB FGF8 GRB2 NEUROG1 PIK3CA OLIG2 PROKR2 MAP2K2;MAP2K1 MAPK1 SOX10 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260910%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADM HADH ACADS EHHADH-1 ACSL1 SCP2 CPT1A PECR HADHB-1 ACADVL SLC22A5 ECI1 ACSL3 ACSL4 ACSF2 HADHA ACADL CPT2 SLC25A20 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260910%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts CHST11 CHST12 CHST13 CHST14 HS3ST1 HS3ST2 CHPF XYLT2 HS2ST1 XYLT1 EXTL2 EXTL1 DSE CHST15 CHSY3 EXTL3 CSGALNACT1 CHPF2 B3GAT3 HS6ST1 HS3ST3B1 B3GAT2 HS6ST2 GLCE HS6ST3 B3GAT1 CSGALNACT2 NDST2 B3GALT6 NDST1 EXT1 CHST7 EXT2 CHSY1-1 NDST4 UST NDST3 B4GALT7 HS3ST3A1 CHST1 CHST3 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260910%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome TRAF6 HDAC3 MAPK3 TRAF2 ESR1 MSN PTEN PARP4 TP53 DOC2A CCT6B PAGR1 SPN PPP4R1 IGFBP3 PPP4R2 QPRT PPP4R4 CCT3 CCT2 UNC13A PPP4R3A PPP4R3B KIF22 TLCD3B ASPHD1 TCP1 KCTD13 TMEM219 ZG16 ALDOA EZR KMT2D INO80E PAXIP1 KMT2C MVP MAZ CASP8 GDPD3 SEZ6L2 CORO1A HIRA PPP4C CDIPT HIRIP3 CCT8 CCT7 PPP2R5D CCT5 CCT4 BPTF IGBP1 C16orf92 MAP2K6 PRRT2 NR3C1 MAP2K3 TBX6 C16orf54 CCT6A TAOK2 CCDC6 PPP2CB;PPP2CA YPEL3 UNC13B SIAH1 PCNA REL PPP2R1A PPARG NFKB1 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260910%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB AJUBA TRAF6 IRAK1 UBE2N IL1A SQSTM1 PRKCZ NFKB1 TIFA UBE2V1 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA1 SLC33A1 ST8SIA3 B3GALT4 ST8SIA5 ST3GAL1 ST3GAL2 ST6GALNAC6 B3GALT1 FUT1 ST3GAL5 B4GALNT1 A3GALT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260910%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAF1 ARAF MAPK3 NRAS RAB5B RAB5C PDCD6IP RAB27A HRAS RRAS2 MRAS HGS RAB5A RRAS HNRNPH1 KRAS BRAF MAPK1 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence HPGD ALOX15 GSTP1 ALOX12 LTC4S PTGS1 DPEP1 ALOX5 LTA4H PTGDS GSTM4 PTGIS EPHX2 PLA2G4A CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX15B TBXAS1 PTGS2-2 GGT1 FADS2 FADS1 CYP2D6;LOC107987479;LOC107987478-1 FPR2 CYP2C9;CYP2C19 GPR32 ELOVL2 ELOVL5 CYP2E1 PTGES CAMKK2 PATHWAY%WIKIPATHWAYS_20260910%WP4874%HOMO SAPIENS CAMKK2 pathway PFKFB2 TRPV4 GATM SPIRE1 MS4A3 HK2 OASL CCR9 CTSE ERMAP GIT1 GALNT9 MAMDC2 HK1 C1QTNF12 ATP10D TSPAN33 SLC25A21 EP300 AHSP TMEM176B IRGC KLF1 SLCO3A1 RHAG RELA ARHGEF7 CCND1 PAK1 VCAM1 SMC1A FAM20C KDR CDC25A CREB1 ULK1 CAMK1 TNF CCNE1 IL15 DNM1L CXCL11 CALM1 PARP1 SREBF1 ACACA FASN RAF1 CDH1 NOS1 NLRP1 MAF CCL5 MTOR MAP1LC3A RPS6 ASNS MAPK1 RAC1 MAPK3 ICAM1 KEAP1 RPS6KB1 AQP1 CAMKK2 ABCA1 HMOX1 HDAC4 NFE2L2 HFE PFKFB3 MAP1LC3B2;MAP1LC3B-1 CD28 SQSTM1 S100A8 SLC2A1 RASGRP1 TBXT HIF1A NFATC2 SIRT1 GCK SLC2A4 RPTOR WDR35 CAMK4 EPOR PCK2 CHRM3 CPOX TSC1 IFI44L ATP1B2 MID1 SPINT1 STIM1 HMBS CRTC2 NEDD4L CYB5R3 TSPAN8 SLC38A5 FIS1 WFS1 PLAC8 SELL AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260910%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy CACNA1F ITPR2 PRKAA1 SERPINE1 MPO CACNA1S PLAU PRG3 CCN2 FGB FGA MCU FGG IL6 RYR1 ATP2A1 MCUB SGCA MMP2 SCX GLI1 CASP9 DAG1 PRKAA2 TOMM20 MMP9 TRPC3 TRPC1 SLC25A5 CACNA2D1 TRDN NFKBIA IL10 ORAI1 CASQ1 TNNI1 SARAF CACNB1 DTNA CACNB2 NOS2 GP2 SSPN SNTB1 SPP1 IL1A CACNG1 VDAC1 TNF HSPA9 NOX4 DMD IL1B PLA2G2A-1 CAMK2D PLA2G4A SMAD4 ELANE TGFBR1-1 TRPC6 SMAD2;SMAD3 CAPN3 CYBB AGTR1 SIGMAR1 PPIF STIM1 FKBP1A TGFB1 ITPR1 NFKB1 TGFBR2 ITPR3 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260910%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1;GLUD2 SLC25A12 GOT2-1 SLC25A22 SLC25A13 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260910%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells PRKCA PRKCQ NLRP7;NLRP2 CSF2 IFNG ELF3 LCP2 PLCG1 TYROBP LAT FYN TNF VAV1 PTPN2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SYK ITPR1 PTPN6 RAC1 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260910%WP4758%HOMO SAPIENS Nephrotic syndrome NPHS1 LMNA ZMPSTE24 NPHS2 WT1 PODXL ITGA3 CUBN SCARB2 SMARCAL1 PTPRO SYNPO CYP11B1;CYP11B2 TRPC6 ACTN4 CD2AP INF2 COL4A3 COL4A5 MYH9 LMX1B CD151 LAMB2 YARS1 PMM2 MYO1E ARHGDIA TTC21B PDSS2 COL4A4 GPC5 EMP2 WDR73 COQ6 ALG1 ARHGAP24 PAX2 ANLN CTLA4 COQ2 APOL3;APOL4;APOL1;APOL2 PLCE1 E2F3 ITGB4 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260910%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway PRKCA PRKCQ CSF2 IFNG LCP2 PLCG1 TYROBP LAT FYN HRAS TNF VAV1 PTPN2 GRB2 CD34 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SYK ITPR1 PTPN6 RAC1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260910%WP34%HOMO SAPIENS Ovarian infertility MSH5 DMC1 CYP19A1 INHA RAD51 ZP2 CDK4 FMR1 ATM VDR NR5A1 CDKN1B CCND2 EGR1 CEBPB SMAD2;SMAD3 SYNE2 NRIP1 ESR2 PGR BMPR1B TSC2 CREB1 AKT1 MTOR NCOR1 TSC1 PTGER2 ZP3;POMZP3 SMPD1 PRLR GJA4 LHCGR TBP FIGLA MLH1 DAZL GDF9 FSHR WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260910%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates SLC2A1 MYC HK2 FBP1 OTUB2 LDHA USP7 USP37 PGAM1 U2AF2 KDR USP44 PGK1 OTUD7B HIF1A USP28 OTUD6B AKT1 G6PC1 MTOR FOXO1-1 VEGFA PIK3CA VHL TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260910%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex H4C6 POLR1A ASF1A POLR1B ASF1B MAPK3 POLR1D MTA1 CREBBP EP300 TLK2 UBTF H2BC21 H2AC14 H2AZ2;H2AZ1 H2AJ HDAC2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 PWWP2B CHD4 H2AC20 CHD3 H2AB2;H2AB3;H2AB1 PWWP2A KAT2A POLR1C RRN3 SRCAP TAF1D TAF1B TAF1C TAF1A EP400 MTA2 MBD3 MBD2 GATAD2B GATAD2A CDK2AP1 KAT2B H4-16 HDAC1 TBP RBBP4 TAF12 HAT1 H4C1 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260910%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ALDH1L1 MTHFR ALDH1A1 CYP2E1 CREB1 MTR-1 CEBPB CBS;CBSL ADH5 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP3941%HOMO SAPIENS Oxidative damage response TRAF6 C1QC MAP2K4 BAD MAPK13 MAPK10 CDKN1A CDKN1B C3AR1 MAP3K9 LOC110384692;C4A;C4B_2;C4B CDKN1C CR2 TRAF1 CASP9 TRAF2 MAP3K1 TRAF3 C5 CASP3 BCL2 C1QB CDC42 BAG4 TDP2 C1S NFKBIE C1R APAF1 TNFRSF1B C5AR1 TNK2 C2 TNF CYCS-1 PCNA BAK1 GADD45A NFKB1 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK9 NRAS MAPK8 COL1A1 MAPK14 HRAS MAPK12 MAPK13 MAPK10 MAPK11 ITGA1 KRAS GRB2 SOS1 FN1 SRC AREG RAF1 PIK3CD TLN1 AKT3 PXN EGFR PTK2 ITGB1 MAP2K2;MAP2K1 MAPK1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260910%WP2596%HOMO SAPIENS Gastric acid production CBLIF CCK GRP PGA4;PGA3;PGA5 SCT GAST PGC VIP MUC6 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260910%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex TERF2 DNMT1 CREBBP DNMT3A FLT3 GABPB1 ZFX PTEN FOXO3 ETV6 SMARCA4 DNMT3B ATM EP300 GABPA SMAD4 GZMH;GZMB-1 MCL1 BCL2L1 BCL2 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260910%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol AKR1D1 CYP7A1 EBP EPHX2 DHCR7 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 LBP ACOX2 ACOT2;ACOT1 CYP8B1 NR1I2 NR1H2 RORC CH25H IL25 ESR1 SLC27A5 CYP46A1 HSD11B1 ESR2 HSD11B2 INSIG1 SCP2 THEM5 ACOT9 HSD3B7 ACOT8 ACOT7 ACOT11 CYP39A1 ACOT12 SULT2B1 ACOT13 CYP7B1 CYP27A1 DBP AMACR BAAT GPR183 IL17D SULT2A1-4 ACOT6 IL17C IL17F SLC27A2 IL17B ACOT4 IL17A EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260910%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IFRD1 IL18 DUSP14 EIF4EBP1 NR4A3 ATF3 ANKRD1 CCN1 IL1A IL1R1 IFNG HBEGF ZEB1 MSTN EIF4E VEGFA JUND MYOG WDR1 ADAM10 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260910%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PC ALDOA AQP9 GAPDH-1 SDS PGAM1 GRHPR PGK1 GPD2 AGXT ENO1 HK1 GK GPD1 PNPLA2 TPI1 GLYCTK LIPE PCK1 KHK PFKL ALDOB FBP1 PKLR G6PC1 AKR1A1 LOC100509620;LOC112267859;AQP7 GPI MGLL MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260910%WP2001%HOMO SAPIENS miR targeted genes in adipocytes TMEM43 FADS1 CAP1 PICALM PHC2 HIPK3 IGF2R SRSF10 CSRP1 CYP1B1 ELOVL5 SRSF9 TMED10 CEBPB LPL TGFBR2 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260910%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium DLL1 PSEN1 RTN4 NGFR MECP2 NTRK1 ERBB4 NTRK3 STAT3 RET NUMB FAIM RTN4R PLXND1 NUMBL MRE11 LRP8 SEMA4A DAB1 NEURL1 APP NEUROG3 RELN MYC ID2-1 MAP2 ASCL1 PAX6 HES1 MEF2C NRG1 IL17A TCF4 CDK5 NOTCH1 GHRL MAPT NGF SOX2 ID1 BDNF CXCL12 JAG1 DISC1 KDM1A VLDLR NDEL1 MARK2 NEUROD1 PAFAH1B1 CDK5R1 MAP1B AGRN HEY1 GSK3B NTRK2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma WNT11 KLF4 DKK1 SOST WNT7B PLAU CTNNB1 TPTEP2-CSNK1E;CSNK1E FRAT2 SOX7 CSNK2A2 CCND3 SFRP4 CCND2 CSNK2B TCF7 DVL1 DVL2 FOSL1 CCND1 MYC DVL3 DKK2 DKK4 FZD10 AXIN1 CSNK2A1;CSNK2A3 SOX17 CER1 LEF1 SERPINF1 CTNNBIP1 SFRP1 SFRP2 SFRP5 CTBP2 CTBP1 TCF7L2 PORCN TCF7L1 WNT5B CSNK1A1 RYK-1 APC KREMEN1 SENP2 ROR1 ROR2 CXXC4 NKD1 NKD2 WIF1 NOTUM ELAVL1 EZH2 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 JUN FZD5 FZD7 FZD6 FZD9 FZD8 FZD1 FZD3 WNT3A WNT5A WNT7A CHD8 WNT2B WNT3 LRP6 GSK3B WNT16 NLK LRP5 MTDH SPINA BIFIDA%WIKIPATHWAYS_20260910%WP5150%HOMO SAPIENS Spina bifida MTHFD1 DNMT1 MTHFR AHCYL2 AHCY SHMT1 MAT1A MTRR DNMT3A MAT2B MTR-1 DNMT3B UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260910%WP4925%HOMO SAPIENS Unfolded protein response IL1B EIF2S1 BCL2L11 ATF6 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF4 TP53 NFE2L2 MBTPS1 ERN1 PPP1R15A XBP1 EIF2AK3 BBC3 PMAIP1 HSPA5 CASP2 BID RTCB MBTPS2 TXNIP DDIT3 BCL2 MONOAMINE GPCRS%WIKIPATHWAYS_20260910%WP58%HOMO SAPIENS Monoamine GPCRs HTR2B ADRB2 HTR2A CHRM1 HTR7 ADRA1A CHRM4 CHRM5 ADRB1 ADRA1D HTR4 ADRA1B HRH1 CHRM2 HTR6 HRH2 DRD5 ADRA2C HTR5A ADRA2B DRD1 ADRA2A DRD2 DRD3 DRD4 HTR1E HTR1F HTR1D HTR1A HTR1B CHRM3 ADRB3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260910%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis APAF1 PRF1 ENDOG DIABLO-1 CASP8 FAS CFLAR BAX HTRA2 FADD CYCS-1 FASLG CASP7 CASP9 CASP6 BAK1 BID AIFM1 CASP3 BCL2 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260910%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation ATG16L1 ATG13 ATG101 ULK1 WDR45B TNF TP53 MAP3K5 RB1 PTK2B RB1CC1 GABARAPL2 TRAF2 PTK2 GABARAP DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260910%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MYC LONP1 TSC2 SLC7A7 CLPP TRAP1 GDF15 MARS1 ATF4 PHB AKT1 OMA1 MTOR PHB2 TSC1 HSPD1 LARS1 SESN2 LONP2 IRS1 EIF2A FOXO1-1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260910%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR3 GPR6 MC5R F2RL1 F2RL3 OR1C1 GPR68 GPR65 GPR63 CCRL2 GHSR GPER1 OR2D2 NPY1R OR2T1 APLNR OR5V1-2 OR2C1 SUCNR1 OR5I1 C3AR1 GPR87 C5AR2 GPR85 MCHR1 OR1Q1 HCAR1 OR2B3 OR2F1-2 OR2J1;OR2J2;OR2J3-2 NMUR2 NMUR1 OR14J1 MLNR OR7C1;OR7C2-9 PRLHR NPY5R OR1F1 OR2H2 AVPR2 OPRM1 SSTR1 SSTR3 SSTR4 SSTR5 OR10A4 HTR1E OR10A5 HTR1F OR2A7;LOC107987545;OR2A4 HTR1D OPN1MW3;OPN1MW2;OPN1MW;OPN1LW HTR1A CNR2 HTR1B OR8B8 OR2W1 OR12D3 OR1D2 OR10J1-2 OPN1SW CXCR5 ACKR4 OR11A1 ACKR2 GPR37 FPR2 LTB4R CMKLR1 AGTR1 AGTR2 GPR83 LPAR4 LPAR5 LPAR6 FFAR2 MAS1 CHRM2 F2R ADRB2 CXCR4 ADRA1B P2RY6 P2RY4 P2RY2 ADORA3 P2RY1 P2RY12 P2RY13 P2RY10 P2RY11 P2RY14 BDKRB1 GPR32 CHRM3 ADORA2B PTGFR PTGDR2 CCR9 TBXA2R PTGDR HTR7 PTGIR RHO CCR8 CCR6 SSTR2 CX3CR1 MC3R LHCGR FSHR HTR2B HTR2A CHRM1 NPY2R ADORA1 ADRA1A MTNR1A MTNR1B HRH3 GPR75 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 ADORA2A OPRL1 CYSLTR2 HCRTR2 HCRTR1 CCR3 NPFFR1 CCR2 FFAR3;GPR42 CHRM4 CHRM5 ADRB1 ADRA1D HTR4 OPRK1 HRH1 HTR6 HRH2 DRD5 ADRA2C HTR5A ADRA2B ADRA2A PTGER4 PTGER2 GPR161 NPFFR2 OXTR RRH GRPR GPR174 GPR173 EDNRA EDNRB GPR171 GPR37L1 TRHR PTGER1 OR7A10;OR7A17-11 PTGER3 OR2AG1;OR2AG2 FPR1 OR1I1 MC2R GALR3 GALR2 GALR1 CYSLTR1 NPBWR1 NPBWR2 OR6B1 CCR10 NTSR1 NTSR2 CCR1 GPR17 XCR1 GPR15 GPR12 NMBR MC1R HCAR2;HCAR3 OR6A2 GPR18 ACKR3-2 BDKRB2 GPR19 GPR27 CNR1 GPR25 GPR21 GPR22 GPR20 NPY4R2;NPY4R OR10H1;OR10H5;OR10H2 BRS3 MC4R CCKAR OR2B6;OR2B2-1 CCR7 FFAR1 CCR5 CCR4 GPR39 AVPR1B GPR34 GPR35 OR2H1-1 OR1A1-1 AVPR1A OR2S2-1 CCKBR F2RL2 OR1E1;OR1E2 OR3A2 OR3A1 OPRD1 GPR45 PTAFR CXCR1 CXCR3 CXCR2 ADRB3 CHML GPR52 GPR1 OR8D2-1 GPR4 GPR50 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260910%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMP2 RUNX2 SMURF1 SMAD1 BMPR1B SMAD6 SMAD4 BMPR1A TOB2 TOB1 BMPR2 NOG NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260910%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death UVRAG AMBRA1 INSR ATG16L1 ATG14 TSC2 ULK2 ULK1 MAP1LC3A TSC1 SH3GLB1 ATG3 ATG10 INS;INS-IGF2 ATG12-1 ATG9B CHAF1A VMP1 BECN1 BCL2 ATG4A ATG7 ATG5 PURINE METABOLISM%WIKIPATHWAYS_20260910%WP4792%HOMO SAPIENS Purine metabolism DGUOK ITPA ADA PRPS1 ATIC ADSL IMPDH1 HPRT1 ADSS2 XDH PNP-1 AMPD1 APRT GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260910%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GGCT GGT1 DPEP1 GSS OPLAH GCLC NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260910%WP5399%HOMO SAPIENS NPHP1 deletion syndrome PTK2B FLNB FLNC MAPK3 NPHP1 FLNA RPGRIP1L BCAR1 MAPK1 INVS PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies JAK2 IL12RB1 IL1B CCR6 IL17RC IL23A STAT3 TNF IL12B CCL20 TYK2 IL22 IL23R CXCL2;CXCL3;CXCL1-1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL17F IL17A CXCL8 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer PDGFD PDCD1 PDGFC IL6 LGALS3 LGALS1 IL13 VEGFB IL10 VEGFD PDGFA IL4 CD40LG PDGFB SHH VEGFA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD28 NT5E IDO1 PVR VSIR B2M TNFRSF4 HAVCR2 FAS ENTPD1 PDCD1LG2 CD226 VTCN1 VDR ICOS TIGIT CCL17 CD276 CCL22 TNFRSF9 TNFSF4 FAP TNFSF9 CXCR4 CXCL12 CD40 LGALS9C;LGALS9;LGALS9B CD86 CD274 CD80 FASLG VEGFC CTLA4 TGFB2 TGFB1 TGFB3 ARG1 PGF RETT SYNDROME%WIKIPATHWAYS_20260910%WP4312%HOMO SAPIENS Rett syndrome TCF4 STXBP1 GABRA3 NCOR2 MECP2 CHD4 SYNGAP1 TAF1B KDM5B TRRAP FOXG1 SATB2 CRK GPS2 RHOBTB2 CECR2 HIVEP2 SCN1A SRRM3 SYNE2 EIF2B2 CDKL5 KCNJ10 SMARCA1 SMC1A SMARCA2 TBL1XR1 IMPDH2 XAB2 HAP1 SCN2A SCN8A SHANK3 SMARCA4 ACTL6B HDAC5 HTT HDAC8 GRIN2A GNAO1 NCOR1 HDAC1 BRAF GRIN2B MEF2C GABRD GABBR2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260910%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DICER1 AGO2 ERI1 XPO5 DROSHA DGCR8 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260910%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling TLE1 DICER1 RUNX2 HMGA2 CDK6 TARBP2 AGO2 ICMT LMNA ZMPSTE24 CTNNB1 SREBF1 FNTA WNT10B CEBPA ADIPOQ CEBPB TCF7 SLC2A4 CCND1 SPP1 EMD CEBPD TOR1AIP1 AXIN1 LEF1 GSK3B HES1 HES5 TCF7L2 PPARG TCF7L1 CSNK1A1 APC SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260910%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder CACNA1C EIF4EBP1 MAPK3 PRKAA1 RHEB RPS6KB1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 HOMER1 PRKAB2 PRKAB1 PTEN GRIN2A GRIN2C GRIN2B GRIN2D CAMK2B NRAS PIK3R3 GRM1 HRAS UBE3A SYNGAP1 NF1 ARC KRAS BDNF DLG4 GRIN1 RPTOR TSC2 SHANK3 CAMK4 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR GRIN3B GRIN3A TSC1 GSK3B NTRK2 PIK3R2 PIK3CA PIK3R1 MAPK1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260910%WP4823%HOMO SAPIENS Genes controlling nephrogenesis EYA1 ILK NCK2 NOTCH2 NPHS1 GDNF NPHS2 WT1 LHX1 CD36 FOXC2 FOXC1 RET ITGA3 CTNNB1 WNT4 ITGA8 CXCR4 CXCL12 NCK1 MAFB CD2AP SIX1 TCF21 KDR LMX1B FGFR2 PDGFB LAMB2 PDGFRB EMX2 FOXD1 SHH HNF1B ROBO2 GLI3 HOXD11 HOXA11 PAX2 SLIT2 KIRREL1 FGF8 MAGI2 ETV4 VEGFA ITGB1 IL7 SIGNALING%WIKIPATHWAYS_20260910%WP205%HOMO SAPIENS IL7 signaling IL7R MAPK3 JAK1 STAT1 BAD FYN STAT3 AKT1 JAK3 IL2RG IL7 PTK2B GSK3B PIK3R2 PIK3R1 STAT5A STAT5B MAP2K2;MAP2K1 MAPK1 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260910%WP3298%HOMO SAPIENS Melatonin metabolism and effects PRKCA TRAF6 PER2 PER1 CAMK2A CYP1A2 SIRT1 TPTEP2-CSNK1E;CSNK1E EDN1 CSNK1D CYP1A1 CLOCK FOXO1-1 ACHE MTNR1A APOE MTNR1B ADRB1 AANAT CYP2D6;LOC107987479;LOC107987478-1 MAP2 CYP2C9;CYP2C19 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 IRAK1 MAOA GSK3B ASMT ECE1 ARNTL NFKB1 CRY2 CALM1 CRY1 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260910%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 PNPT1 XRN1 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260910%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation ITGB3 ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 LATS2 CTNNB1 ITGA1 ITGAD ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PRKACB-1 PRKAR2B CCND1 PRKAR2A PAK1 MYC PAK3 PAK2 PRKAR1B PAK4 KDR PRKAR1A PDGFRB RBX1 KIT PPP1CA WWTR1 PLCB4 PPP1CB PPP1CC TEAD2 CDH1 CTNNA1 DDB1 FLT3 CDH9 AMOT EPHA2 CDH7 DCAF1 CXCL10 CDH5 CUL4A CDH4 CDH3 CDH20 CDH22 CDH24 NGFR PPP1R12A CDH10 CDH11 CDH12 NTRK1 CDH13 CDH15 CDH17 CCN2 CDH18 VGLL4 CDH19 PPP1R14A CDH6 CDH2 IGF1R CDH16 INSR PDGFRA FLT4 CSF1R EGFR NRAS STK3 SAV1 LIN28B CD44 YAP1-1 HRAS TEAD1 TEAD3 TEAD4 MST1 LATS1 KRAS NF2 BUB1B-PAK6;PAK6 AJUBA MET ITGA2B PAK5 FGFR4 PRKACA-1 FGFR3 FGFR2 FGFR1 TEK NTRK2 CDH8 PTK2 ITGA10 FLT1 ITGA11 FOXM1 ITGB1 ITGAM ITGB5 ITGB4 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260910%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation TRAF6 CBLB CD3G CD3E IKBKB PDPK1 ELOB IKBKG CHUK VAV1 PCBP2 CD247 ITK CDKN1B SMARCB1 DGKA CD3D TMEM222 GRAP2 RELA GRB2 ARIH2 UBASH3A RHOH RASA2 AGO3;AGO1 NFKBIA CARD11 BCL10 PTPN6 MALT1 ZFP36L1 RPRD1B SH2D1A FIBP CD5 LCP2 LAT GNA13 MAP3K8 CD28 MAP3K14 PRKCQ PLCG1 MAP4K1 CUL5 RNF7 TNFAIP3 LCK CD8A MEF2D DGKZ NDUFB10 AKT1 SOCS1 REL PIK3R2 PIK3R1 ZAP70 SH2B3 NFKB1 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260910%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260910%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 MYD88 TRAF6 IRF3 IKBKB IKBKG CHUK TICAM1 RELA TRAF3 TICAM2 TIRAP TLR1 TLR9 TLR5 TLR8 TLR6 TLR2 TLR7 TLR4 TLR3 IRAK1 REL RELB TBK1 IRF7 TOLLIP IRAK4 IKBKE NFKB1 MAPK1 NFKB2 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260910%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G5 PLA2G6 ALOX5 PLA2G2D PLA2G1B PLA2G12A PLA2G4F HRAS PLA2G12B PLA2G4D PLA2G4A PLA2G4E TP53 PLA2G3 PLA2G7 CDKN1A SLCO2A1 PLA2G10;LOC100652777 PTGS2-2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260910%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin PRKCA ADRB2 NPR1 ANKRD1 MYPN CAMK2A GUCY1B1 ADRB1 PRKACB-1 RAF1 PRKACA-1 PRKAR1A PRKG2 MDM2-2 TRIM63 FHL1 GUCD1 CSRP3 PLCZ1 ANKRD2 ANKRD23 TTN-1 NBR1 TCAP FHL2 CRYAB MAP2K2;MAP2K1 TRIM55 MAPK1 SRF NUP62 HUNGER AND SATIETY%WIKIPATHWAYS_20260910%WP5445%HOMO SAPIENS Hunger and satiety PYY GCG POMC MC4R AGRP NPY GHRL LEP ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260910%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma MYL3 ADRB2 ADCY3 ADCY8 PLCB3 PLCB4 GNAS-1 PLCB1 PLCB2 NR3C1 ADCY4 ADCY2 PRKACB-1 ADCY7 ADCY6 PRKAR2A ADCY5 PRKACA-1 PRKAR1B PRKAR1A CREB1 ADCY9 ADCY1 MYL4 MYL2 MYL1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260910%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO3 FMO4 FMO5 FMO1 FMO2 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260910%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways MAT2A SARDH MTR-1 GPX6 CBS;CBSL MAT1A BCAT1 SHMT2 BCAT2 PLD1 MTHFR SOD3 SOD1 CTH GPX5 BHMT2 BAAT ALDH7A1 PCYT1A DNM1 DMGDH AHCYL1 CSAD AHCYL2 SLC25A48 DNMT3L AHCY GAD1 PCYT1B SHMT1 GPX7 PHGDH DNMT3A MTHFD2L MAT2B GAD2 TYMS CHKA AGXT2 GNMT PSPH MTHFD1L ETNK2 DNMT3B CEPT1 CDO1 AMT DHFR2;DHFR CHKB PCYT2 BHMT MTHFD1 MTHFD2 CHDH GPX1 GPX4 PEMT GSS PSAT1 CHPT1 GSR GCLC GCLM ETNK1 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260910%WP2005%HOMO SAPIENS miR targeted genes in muscle cell NRP1 PKM GJA1 RHEB CACNA2D1 ESR1 CCND1 ERBB2 DSG2 FGF2 DHX15 PTBP2 UBE2J1 KIT SLC38A1 NT5E PPP3CA CPNE8 VEZT ACAA2 SRPRB-1 BACE1 ZEB1 ARF4-1 PWP1 SRSF10 CDIPT CIAO2A POGLUT3 RARS1 TPM3 FNDC3B G6PD FNDC3A EIF4E DHX40 RAB34 RAI14 SRSF9 TMED10 CBFB MRPL20 BCL2 COMMD9 ANPEP SLC38A2 ATP6V1C1 SLC4A10 TBCA MOV10 NCL-1 WNT5A CHMP2A ANP32B PICALM TRAM1 ADAR MAGT1 MRC2 SPTLC1 CYP1B1 SH3BGRL3 TMED7 TMED2-1 SEC24A ATRX CAPG PPIF CSDE1 PXDN PTMA MTPN SEC23A DNAJB1 POLR2C PPP1R7 SH3BP4 RTN4 PDLIM7 MPZL1 SLC12A2 COL1A1 GALNT7 COL1A2 TXNRD1 ERBB3 GALNT1 AP3D1 GSTM4 ARCN1 SPCS3 FMNL2 ATP6V0E2;ATP6V0E1 NEDD4 PDCD4 SLC7A11 LAMTOR5 ATP2A2 BET1 AGO3;AGO1 COL3A1 SYNE2 SYNE1 TMEM43 NCOA3 GNA13 EGFR TPM1 CDKAL1 HES1 E2F3 PRKCI SLC12A4 NOTCH2 NOTCH1 TYMS LAMC2 CYP51A1 LAMC1 BACH1 CHORDC1 RAVER2 CDK5RAP1 ANKFY1 SEC62 MTHFD2 VPS39 CDK5RAP3 TMEM41B-1 MBNL1 SCAMP1 CXCL12 CARHSP1 METTL7A-1 PDE3A WDR82 KCNQ1 FAR1 TMEM87A HACD3 GRPEL2 PANX1 ATP6V0A1 SNX6 RAB27B NCEH1 SFXN1 PTPA GFM1 ASH2L PTPRJ PTPRF COIL PISD HYAL3 TMED3 GNL3L-1 GNPNAT1 CTSC MRPS24 RHOG AP3B1 CPOX GAK SLC7A6 CDCP1 VSNL1 FRG1 BRPF3-1 SSNA1 AMIGO2 FSTL1 NAPG SLC38A5 PGRMC1 SHOC2 CA12 ITGB4 SPRYD4 TTC9C WDR11 TPPP3 SNX15 LRRC8A NUCB1 MAPK7 LAMTOR3 TUSC2 LTN1 ARID4B SDCBP LCLAT1 PODXL ABHD10 MAPK14 KPNA3 MAPK12 TPM4 TPM2 ATG9A CTNNB1 STX7 ITGA2 RB1 PKN2 UBE4A CSNK1D CDKN1A RAB30 CDKN1B DMTF1 WDFY1 MATR3 CLOCK GEMIN7 ERG SLC1A4 UAP1 CORO1C SLC9A3R2 CAMTA1 RAB6A ANAPC1 CD164 CNOT9 SLC25A1 DOCK5 CALCOCO2 SNAP23 DOCK7 TNFAIP2 CHD1 TMEM109 SLC25A13 PLK1 ACP2 SNAP29 SCYL1 HSDL1 ARHGDIA ARID1A RCN2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A RFT1 RBMS1 YWHAQ LUZP1 NUFIP2 NXN UHRF1 ACVR1B CAND1 TP53INP1 E2F1 IGF2BP1 ZNF622 PDLIM5 SLC25A24 MYO10 EHMT2 TM6SF1 SLC4A7 EHMT1 SLC25A32 SRF NAA15 CDK6 CCNG1 DNMT3A EZH2 IRS1 MYLIP ADIPOR2 RAD23B RDH10 TDG GFPT1 POLD2 USP1 PPIB TGFBR2 POLE4 IFRD1 CCN1 ABCG2 MTRR GPD2 HIPK3 CUL4B IGF2R CSRP1 ELMOD2 TXN2 CEBPB C1QBP HMOX1 SYPL1 SPARC HDAC4 POLA2 CSF1 NELFCD ATAD3A;ATAD3B MCL1 HSD17B12 GRIA2 PGM1 KRAS P4HA2 NF2 PSAT1 CLDN1 GPAM AXL MET PAFAH1B2 STRN FADS2 MYO1E PHLDB2 THBS1 NFIA IPO4 LRP1 LMNB2 LPL NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260910%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling LRRC8A ADCY8 FOS SLC1A4 DLD PDHA1 CNTF CREB1 FGF2 TNF IL10RB GRIN2A ADCY1 SLC38A1 GRIN2C LIF GRIN2B GRIN2D IGF1 CALM1 GOT1-1 GLUL NSMF SLC1A6 IL1B SLC38A3 GLS2 GRIA3 PPP1CA GRIA4 SLC1A3 TRPM4 DAO SLC6A9 GRM5 GRIK5 GRIK3 GRIK4 GRIK1 PLCB3 GRIK2 SLC7A10 PLCB4 PPP1CB GRM2 SLC17A6 PPP1CC GRM4 SLC17A7 GRM7 TNFRSF1A GRM8 PLCB1 DLAT PLCB2 IRS1 TRAF5 LTA BDNF SRR LRRC8C LRRC8D LRRC8B LRRC8E TGFBR1-1 BCL2 DISC1 CAMKK1 SLC38A2 IL13RA1 GRIN1 NOS1 TNFRSF1B IL1R1 IFNGR2 AKT1 GRIN3B GRIN3A STAT6 TGFB2 IL4R TGFB1 TGFB3 SOCS3 NFKB1 IL10RA NFKB2 MAPK1 TGFBR2 IL6R MAPK3 JAK1 STAT1 STAT3 IL12B IL6 IL13 SLC1A2 IL6ST SHMT2 CAMKK2 IL10 INSR GFAP CFL1 IL4 IL1A IFNG IL12A SMAD7 SLC1A1 IL1R2 PRKCG PRKCB PRKCA SLC2A1 ADCY3 CAMK2B GRIA1 GLS SHMT1 CAMK2D PHGDH CAMK2A GRIA2 PSPH GRM1 CAMK2G NGF ARC SMAD4 PSAT1 SMAD2;SMAD3 IFNGR1 PRKACA-1 CAMK4 TGFBR3 SLC38A5 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260910%WP4298%HOMO SAPIENS Acute viral myocarditis ITGB2 ILK ITGAL MAPK3 JAK1 RAC3 STAT1 ABL2 STAT3 IL12B CCR3 EDN1 IL6 SGCD SGCA SGCB CASP9 DAG1 SGCG MMP9 SOS1 BCL2L1 CASP3 IL10 SRC CCND1 IL2 IFNG CD40LG ENDOG CREB1 IL12A AIF1 TLR4 TNF TLR3 CD55 ACTB-1 CYCS-1 CD4 PYCARD ABL1 CASP7 CASP1 CASP6 CASP2 BID RASA1 MYH6 DMD CASP8 BAX PARP1 EIF4G1 TICAM1 CXCR4 LAMA2 NOD2 CAAP1 HLA-DMA PTCRA BCL2 DFFB DFFA CXADR KRT8 CHRAC1 BNIP2 PABPC1;PABPC3 EIF4G2 NOS1 CCR5 TLR5 FYN AKT1 CD80 SOCS1 GSK3B CAV1 PIK3R1 TGFB1 MAPK1 NFKB2 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260910%WP3601%HOMO SAPIENS Lipid particles composition APOC3 APOC2 APOA1 CETP APOA2 APOE APOB LPL LDLR LCAT ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260910%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 TP53 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260910%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260910%WP2857%HOMO SAPIENS Mesodermal commitment pathway DLL1 GATA6 FOXC2 VAV3 FOXC1 PITX2 HPRT1 ZFHX4 SESN1 CCND1 HNF4A PRKAR1A AXIN2 SOX17 PAX6 TOX3 CTBP2 SRF BMP4 TCF4 IQCJ-SCHIP1;SCHIP1 ELK4 PBX1 CRTC1 FOXA1 SOX2 TEAD2 ACACA PPP2CB;PPP2CA FOXA2 SOX21 TRIM28 WNT3A CEP250 RARG DIP2A RPL38 HES7 ACVR1 WNT3 EOMES WDHD1 ZNF281 PIAS1 EMSY ADAM19 TOX TWSG1 WDFY2 BCORL1 BHLHE40 MACF1 MBTD1 ACVR2A EPB41L5 RARB UBR5 ATP8B2 PBX3 GDF3 TRERF1 NLK CCDC88A NABP2 TRIM71 SETD2 NCAPG2 PHF6 JAK2 CSRP2 ZIC2 ZIC3 TRIM5 KLF4 DKK1 JARID2 KDM6A SLC2A12 MSGN1 TET1 PARP8 ARL4A DDAH1 CUL4B PLCH1 AEBP2 MTF2 HAND1 AHDC1 C9orf72 WDCP AMH ASCC3 SNAI1 ZNF462 ELP4 GRHL2 ACVR2B TBX3 MEIS1 RGS10 C1QBP TBX1 ARID5B BMP7 EXT1 EXT2 GATA3 NFE2L2 HTT AXIN1 KLF5 LEF1 FGF8 TCF7L1 POU5F1;POU5F1B HMGA2 CHRD NANOG;NANOGP8 YAP1-1 TEAD1 DNMT3B MIXL1 NODAL LATS1 SMAD1 SMAD4 TBX6 FZD5 FZD4 CCDC6 SMAD2;SMAD3 FZD8 PRKACA-1 BMPR1A FGFR1 LEFTY2;LEFTY1 BMPR2 NOG FOXH1 INHBA SMAD6 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP304%HOMO SAPIENS Kit receptor signaling JAK2 TEC MAPK3 STAT1 BAD MAPK14 STAT3 PTPN11 EP300 VAV1 GAB2 RPS6KB1 CBL GRB2 INPP5D SOS1 CRK LYN GRB10 STAT5A STAT5B MATK BTK SHC1-1 MITF DOK1 PTPN6 SRC SOCS6 SH2B2 KITLG KIT PRKCB PRKCA GRB7 MAPK8 PLCG1 HRAS RPS6KA3 RPS6KA1 MAPT CRKL RAF1 FYN FOXO3 AKT1 SOCS1 RPS6 PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260910%WP5601%HOMO SAPIENS Caffeine in blood vessels ADCY3 RYR3 RYR2 ADCY8 PPP1R12A PPP1CB GUCY1A2 ADRA1A GUCY1A1 PDE3A ADCY4 ADCY2 ADRA1D ADCY7 ADCY6 PDE3B ADRA1B CALM3;CALM1 MYLK ADCY5 PDE4B PDE4A PDE4D-1 PPP1R12C ADORA3 NOS3 ADCY9 ADORA2A ADORA2B ADCY1 CALM1 CALM2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260910%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MYD88 TRAF6 MAP3K7 IRF3 JAK1 MAPK8 STAT1 MAVS MAPK14 IKBKB RIPK1 TYK2 IKBKG CHUK TICAM1 FOS JUN TRAF3 NFKBIA IFNAR2 STAT2 OAS3 TLR7 OAS1 IRF9 IFNAR1 IFIH1 EIF2AK2 TBK1 IKBKE NFKB1 DDX58 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260910%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC6A6 SLC15A2 CARNS1 SLC15A4 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260910%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STK11 PRKAA1 CTDSP1 STRADB PTBP1 SIX4 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260910%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFAB1 NDUFS5-1 NDUFA12 NDUFB11 NDUFA10 NDUFA13 NDUFC1 NDUFS6 NDUFS4 NDUFB3 NDUFS3 NDUFS2 NDUFS1 NDUFB9 ECSIT NDUFB8 NDUFB7 DMAC2 NDUFB10 FOXRED1 NDUFB6 TMEM186 NDUFB5 TMEM70 NDUFB4 NUBPL ACAD9 NDUFB2 NDUFAF6 NDUFAF7 NDUFB1 NDUFAF4 NDUFAF2 NDUFAF3 TMEM126B NDUFAF1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFV1 TIMMDC1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260910%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins EPB41L2 NCDN EFNA5 NEO1 MAPK9 NTNG1 CADM3 APLP2 CADM1 CASK ANK3 TERF2IP MAPK4 SNW1 ATP2B1 PRKCZ RAP1GAP GRIK2 PLCB4 KCNQ2 CAMK2G KCNJ6 CDH2 STX2 DAB1 GRIN1 CLASP1 AGRN KCNMA1 CAV2 GPHN GRIN2B EPB41 GABRG3;GABRG2 CLSTN1 STXBP2 CSN3 EPB41L1 CHL1 GABBR2 GPCRS OTHER%WIKIPATHWAYS_20260910%WP117%HOMO SAPIENS GPCRs other PTGFR HTR7 UTS2R CCR2 C5AR2 OR2F1-2 ADRA1D CHRM2 OR1F1 SSTR2 F2R OR10A5 OR2A7;LOC107987545;OR2A4 HTR1F GRPR EDNRA PROKR2 FSHR ADRB2 HTR2A SMO OR2M4 GPR61 GPR62 CELSR1 GRM1 NTSR1 RXFP1 OR7E24-1 CELSR3 GPR17 RXFP3 GPR176 GPR132 ADGRE3 S1PR1 GNRHR GPR135 ADGRV1 OR8G1;OR8G5 GPR18 TAAR5 OR1J2 TAAR2 CNR1 OR1N1 GPR162 LTB4R2 ADGRF5 VN1R1 OR6C3 GPR88 GPR84 OR2B6;OR2B2-1 MCHR2 GHRHR ADGRG1 CCR5 HRH4 ADORA3 OR6C2;OR6C68 ALG6 OR5AC2-2 GPR55 DRD3 ADGRD1 DRD4 P2RY13 GPR143 OR2H1-1 ACKR1 P2RY11 OR2A5 ADORA2A LGR6 ADGRL2 CCKBR ADGRL3 CHRM3 OR1E1;OR1E2 OR3A1 CELSR2 CXCR1 GPR183 CXCR3 CXCR2 GPR83 FOXP3 IN COVID 19%WIKIPATHWAYS_20260910%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL6R IL2RA IL2 IL2RB IL7R FOXP3 STAT3 CD86 CD80 IL2RG IL6 IL6ST CD28 STAT5A STAT5B SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260910%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260910%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PPP3CA PPP3CB CAMK2D CTF1 MAPK8 MAPK14 STAT3 GATA4 MAPK11 AGT MYEF2 RHOA EDN1 LIFR FOS MAP2K3 JUN IL6ST NFATC4 CALM1 PRKCB MAPK1 PRKCE RAC1 NRF2 PATHWAY%WIKIPATHWAYS_20260910%WP2884%HOMO SAPIENS NRF2 pathway SLC5A6 ALDH3A1 SLC5A9 CES3 CES2 EPHA3 SLC5A3 SLC5A5 CES5A PTGR1-1 SLC5A4 RXRA PRDX6 SLC6A5 SLC2A9 SLC6A7 SLC6A19 SLC6A8 MAFF SLC2A5 PPARD SLC2A6 SLC2A7 SLC2A8 SLC2A11 SLC2A10 ABCC5 SLC2A13 SLC39A11 SLC39A10 SLC39A13 SLC39A12 EGR1 SLC39A14 SLC5A11 SLC5A12 SLC5A10 CBR3 TXNRD3 PDGFB FTL-1 SLC6A9 ABCC3 ABCC4 G6PD ABCC2 BLVRB GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GCLC ME1 GSTA3;GSTA5;GSTA1;GSTA2 SLC6A1 GCLM SLC6A2 GGT1 SLC6A3 SLC6A4 SLC5A7 TGFB2 TGFB1 MGST3 EPHA2 MGST2 TGFBR2 DNAJB1 AGER SRXN1 CES1 SERPINA1 SLC2A12 HBEGF TXNRD1 GSTM4 GSTM3 PRDX1 KEAP1 HGF MAFG SLC7A11 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TGFA SLC6A18 SOD3 SLC5A8 HMOX1 SLC6A6 NFE2L2 UGT1A1;UGT1A6 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC5A2 SLC6A20 NRG1 SQSTM1 SLC2A1 GSTP1 FGF13 SLC6A11 HSP90AB1 CYP2A13;CYP2A6;CYP2A7-1 SLC2A2 CBR1-1 HSP90AA1 GSTA4 SLC5A1-1 SLC2A4 NQO1 HSPA1A;HSPA1B SLC39A9 FTH1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC6A13 TXN PGD SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260910%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD CHUK IKBKG THBD AGER RELA HMGB1-1 NFKBIA NFKB1 IKBKB CCL18 SIGNALING%WIKIPATHWAYS_20260910%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 AK4-1 CDH2 PTK2B CCR8 MMP2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260910%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOB UBB;UBC RUNX1 RBX1 CUL5 CBFB ELOC-1 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NEU2 FUCA1 ST3GAL4 NAGA B4GALT1 B3GNT5 FUT2 FUT1 FUT6;FUT5;FUT3 B4GALT4 B4GALT3 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX15 ALOX5 EPHX2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260910%WP4249%HOMO SAPIENS Hedgehog signaling SMO CSNK1G1 SPOP DHH TPTEP2-CSNK1E;CSNK1E CUL3 ARRB1 CSNK1D ARRB2 SMURF1 GLI1 LRP2 CCND2 PTCH1 BCL2 PRKACB-1 CCND1 PRKACA-1 HHIP GRK3 GRK2 KIF3A BOC EVC2 CSNK1G3 PTCH2 IHH GLI2 FBXL17 SHH KIF7 EVC SPOPL GLI3 GAS1 SMURF2 CSNK1G2 GPR161 CDON CSNK1A1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260910%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC2A1 SLC7A11 SLC1A5 GLS PSAT1 PHGDH PSPH DNA REPLICATION%WIKIPATHWAYS_20260910%WP466%HOMO SAPIENS DNA replication UBB;UBC MCM2 POLE2 RPA3 CDK2 POLA1 UBA52 MCM7 POLE RFC5 RFC3 RFC4 MCM3 RFC2 MCM4 MCM5 MCM6 PRIM2 PRIM1 ORC5 RFC1 ORC4 CDC45 ORC6 ORC1 ORC3 CDC7 ORC2 CDC6 POLD3 POLD4 POLA2 POLD1 POLD2 PCNA GMNN MCM10 CDT1 DBF4 RPA1 RPA2 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260910%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness ITGB3 RYR3 PRKCQ MAPK3 CREB1 ITGAV PLCG1 TNNC1 MFAP5 JUN PTK2 MAPK1 ITPR3 ESTROGEN METABOLISM%WIKIPATHWAYS_20260910%WP697%HOMO SAPIENS Estrogen metabolism COMT NQO1 STS CYP1A2 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ARSD-1 ARSL GSTM1;GSTM2-1 GSTA3;GSTA1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 VAMP2 CREB1 YAP1-1 BCL2L11 CDKN1A POMC CDKN1B FOS IL6 CDKN1C CRP ADIPOQ VEGFA INS;INS-IGF2 PPARG ZINC HOMEOSTASIS%WIKIPATHWAYS_20260910%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A2 SLC30A5 SLC30A4 SLC30A1 MT3 MTF1 SLC30A9-1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC39A2 SLC39A1 SLC39A4 SLC39A9 SLC39A3 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC30A10 SLC30A7 SLC30A6 SLC30A8 SLC30A3 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260910%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2C ERCC3 TAF7 TAF6 TAF5 ELK1 NELFB NELFA NELFCD MED9 NELFE CCNC-1 POLR2A MED19 MED16 MED18 MED17 MED12 MED11 MED14 MED13 MED10 MED1 MED8 MED4 GTF2F1 MED27 MED26 MED6 MED29 MED7 MED23 MED22 MED25 MED24 THRA MED21 MED20 GTF2A1 MED28-1 CTDP1 MED15 MED30 POLR2D POLR2L POLR2M TAF10 TAF11 TAF8 MED31-1 TAF4 TAF3 TAF2 TAF1 GTF2B TAF9 GTF2E2 POLR2B POLR2E POLR2F CDK8 POLR2G POLR2H POLR2I TBP TAF12 TAF13 POLR2J;POLR2J2;POLR2J3 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260910%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 NBN MRE11 DDX1 DROSHA ATM DGCR8 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260910%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production IDO1 NMRK1 NMNAT3 NADSYN1 NMNAT2 NMRK2 NAPRT NMNAT1 NAMPT QPRT AADAT HAAO KMO TDO2 KYNU AFMID INSULIN SIGNALING%WIKIPATHWAYS_20260910%WP481%HOMO SAPIENS Insulin signaling MAPK9 MAPK7 PRKAA1 MAPK6 MAPK4 MAP4K5 MAPK14 MAPK12 ELK1 MAPK13 IKBKB PDPK1 MAPK10 MAPK11 FOS RHEB RAPGEF1 CBL PRKAA2 CRK EGR1 LIPE SNAP23 SORBS1 SNAP25 KIF3A RPS6KA5 XBP1 MAP3K8 MAP3K3 GSK3A MAP3K14 SRF GRB14-1 VAMP2 STXBP1 MAPK8 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K9 MAP2K7 IRS1 EIF4E MAP3K4 IRS2 MAP2K6 MAP2K3 FOXO1-1 JUN MAP3K1 MAP3K10 RAF1 MAP3K11 TSC2 IRS4 KIF5B AKT2 INPPL1 AKT1 CBLC MAP3K5 MTOR RPS6KA4 ENPP1 MAP3K6 GYG1 SOCS1 INPP4A STXBP3 GSK3B STXBP4 RRAD PIK3R2 PPP1R3A PIK3R1 EHD1 ARHGAP33 SOCS3 EHD2 MAP3K13 MAP2K2;MAP2K1 ARF1 MAPK1 FLOT1 RAC1 TRIB3 FLOT2 EIF4EBP1 MINK1 CBLB MAP3K7 RHOJ PTPN1 RHOQ ARF6 MAPK3 CYTH3 STX4 MAP2K4 SGK3;C8orf44-SGK3 MAP3K2 REG1B;REG1A CAP1 MYO1C PRKCD PFKM GAB1 GYS2 PTPN11 MAP3K12 GYS1 SGK1-1 IGF1R RPS6KB1 GRB2 SOS1 GRB10 SHC1-1 SHC2 SH2B2 INSR PTEN SOS2 PRKCI PRKCH STXBP2 PRKCB PRKCA SLC2A1 RPS6KB2 PRKCQ PIK3R4 PIK3R3 PRKCZ HRAS MAP4K3 MAP4K4 MAP4K1 MAP4K2 SLC2A4 PFKL RPS6KA6 PTPRF FOXO3 PIK3CD PIK3C2G SHC3 PIK3CB PIK3C2A PIK3CG TSC1 MAP2K5 TBC1D4 PIK3CA RAB4A PIK3C3 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260910%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 ELOVL2 ELOVL5 ACOT2;ACOT1 FADS2 FADS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260910%WP5293%HOMO SAPIENS Acute myeloid leukemia EIF4EBP1 MAPK3 CSF2 BAD MPO SPI1 STAT3 DUSP6 IKBKB BCL2A1 PPARD CEBPE FCGR1A IKBKG CHUK RUNX1T1 JUP ZBTB16 CEBPA RPS6KB1 RELA GRB2 GLI1 CCNA1 SOS1 STAT5A STAT5B TCF7 CCND1 MYC RUNX1 CSF1R IL3 CCNA2-1 SOS2 LEF1 PIM2 KIT TCF7L2 TCF7L1 PML RPS6KB2 PER2 NRAS PIK3R3 CD14 HRAS KRAS RAF1 ARAF FLT3 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR RARA PIK3R2 BRAF PIK3CA PIK3R1 PIM1 ITGAM MAP2K2;MAP2K1 NFKB1 MAPK1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260910%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2J2-1 GSTP1 COX8A COX5A CYP2C9;CYP2C19 EPHX2 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260910%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260910%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260910%WP5146%HOMO SAPIENS Lung pathology of COVID 19 IL18 CXCL10 IRF3 IL1B CSF2 MAVS TLR8 STING1 TLR7 TNF TLR3 CCL13;CCL2 CXCL9 CGAS IL6 IFIH1 TBK1 NFKB1 CXCL11 DDX58 ANGIOGENESIS%WIKIPATHWAYS_20260910%WP1539%HOMO SAPIENS Angiogenesis KDR FGFR2 CREBBP PDGFRA NOS3 HIF1A PLCG1 PDGFB MAPK14 TIMP2 FGF2 TIMP3 AKT1 ANGPT1 TEK SMAD1 VEGFA MMP9 PTK2 PIK3CA FLT1 ARNT MAPK1 SRC SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260910%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 NRP1 ACE2 FURIN KDR VEGFA MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260910%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A KEAP1 SLC3A2 SLC7A11 SLC1A5 SLC7A5 ATF4 NFE2L2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260910%WP4752%HOMO SAPIENS Base excision repair SMUG1 NTHL1 POLE2 APEX1 XRCC1 POLE3 PARP1 FEN1 OGG1 POLB PARP3 APTX POLG POLG2 POLL TDP1 POLE ADPRS NEIL1 RFC5 RFC3 RFC4 RFC2 PARP2 RFC1 PNKP HMGB1-1 UNG POLD3 POLD4 TDG PARP4 POLD1 MPG POLD2 LIG1 PCNA MUTYH MBD4 LIG3 NEIL3 NEIL2 POLE4 MALE INFERTILITY%WIKIPATHWAYS_20260910%WP4673%HOMO SAPIENS Male infertility SLC46A1 EP300 CLU CLOCK POLG ESR1 RFC1 TNF MDM2-2 GNAO1 SOX5 HLA-DRA LIG4 ARNTL DAZL XPC MSH5 DDX20 XRCC4 KDM3A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FAS PARP1 ATM POLB GPX1 PEMT APOB BCL2 NOS1 PMS2 MLH1 SIRPA;SIRPB1;SIRPG ETV5 MTRR ERCC1 CREBBP AR ERCC2 MTR-1 CYP1A1 MMP2 MMP9 CCNA1 CCNK IHO1 UBR2-2 SLC16A7 CYP26B1 RGS9 RAG1 NANOS1 USP8 INSR NOS2 PRDM7;PRDM9 MTHFR PRM3 SPATA17 ESR2 SOD3 MSH4 TSSK6 TSSK4 TCN2 DDX4 STRA8 UBD MOV10L1 TMEM132E BRCA2 UBE2B XRCC2 NFE2L2 CCNT1 XRCC3 PUM2 CCNT2-1 PIWIL2 AHR CRISP2 EPPIN;EPPIN-WFDC6 PIWIL1 PIWIL4 PIWIL3 SPO11 CAT SEPTIN12 YBX2 CHD2 CDK9 KLK3;KLK2 ABCB1 HORMAD2 HORMAD1 MSMB PRMT6 PACRG TEX15 AGO2 AHRR USP26;USP29 SHMT1 LTF CYP17A1 PON2 PON1 DND1 CXXC1 ABLIM1 OR2W3 PEX10 LRWD1 CDC42BPA MLH3 BHMT REC8 FOLH1B;FOLH1 CTCFL MTHFD1 TRIP13 BRDT PSAT1 SRD5A2 NQO1 NOS3 FASLG THBS1 XRCC5 H4C1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP2369%HOMO SAPIENS Histone modifications H4C6 H3-3A KMT2D KMT2C H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EZH2 AEBP2 KMT2E SETD4 SETD5 SMYD2-1 SETD3 SMYD5 SETD9 SETD6 KMT2B DOT1L SETD7 PRDM2 NSD1 SMYD1 KMT2A KMT5B SMYD4 KMT5A SMYD3 SETDB1 SUV39H1 KMT5C EED SETD1B SUV39H2 SETD1A SETMAR ASH1L SETBP1 EZH1 H4-16 SET-1 EHMT2 SETD2 EHMT1 H4C1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260910%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17RA IL17RC TLR4 IL17A ANO6 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260910%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCA CDK4 CDK2 GLB1 ASAH1 RB1 CDKN1A S1PR1 PLCB1 S1PR2 S1PR5 SPHK1 TERT SPTLC1 GBA MTOR SGMS2 SMPD3 UGCG KDSR RPP38 CERS4 E2F1 SGPP1 DEGS1 CERS2 MAPK1 PRKCB BDNF TRKB SIGNALING%WIKIPATHWAYS_20260910%WP3676%HOMO SAPIENS BDNF TrkB signaling EIF4EBP1 NRAS PLCG1 HRAS GAB1 RPS6KA1 GAB2 ARC RHEB RPS6KB1 KRAS EEF2K BDNF GRB2 DLG4 TRPC3 SOS1 SHC1-1 TRPC6 HOMER1 GRIN1 TSC2 CREB1 AKT1 MTOR PIK3CG TSC1 ADCY1 MKNK1 NTRK2 BRAF MAP2K2;MAP2K1 MAPK1 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260910%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH3 ALKBH2 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260910%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption ARHGDIB ADCY3 VAMP2 STX4 RAB5A GNAS-1 DCTN6 DCTN4 CREB3L3 CREB3L4 DYNC2H1 CREB5 CREB3L1 DYNC1H1 DYNC1I2 PRKACB-1 RAB11B ADCY6 CREB3L2 DYNC2LI1 PRKACA-1 AVPR2 DCTN1 DYNC1LI1 DYNC1LI2 RAB5B CREB1 RAB5C ARHGDIA ADCY9 DYNC1I1 AVP ARHGDIG NSF CREB3 DCTN5 DCTN2 AQP4 RAB11A AQP2 AQP3 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260910%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 H3-3A SMARCD2 SMARCD3 DPY30 RBBP5 PAXIP1 WDR5 KDM6A KMT2C SMARCC1 RXRA MBD5 SMARCC2 NCOA6 ACTL6A ARID1B ASXL1 BAP1 SMARCB1 NR1I3 SMARCA2 ASH2L ARID1A SMARCA4 ACTL6B PAGR1 EHMT1 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260910%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 NPAS2 POLR1E CREBBP CREB1 DDX21 NCOA3 FBL IRF2 ALX1 MAFG PCNA CLOCK SMAD4 FOXO1-1 ARNTL IL19 SIGNALING%WIKIPATHWAYS_20260910%WP5422%HOMO SAPIENS IL19 signaling MAPK3 JAK1 MAPK8 COL1A1 STAT1 MAPK14 STAT3 MMP1 TNFRSF1A IL20RA IL20RB IL19 MUC5AC CXCR4 SOCS5 CCL11 IL4 TNF AKT1 CCNB1 SOCS1 ACTA2 STAT6 IL4R TGFB1 NFKB1 MAPK1 RAC1 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260910%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway BMP4 IL6R DKK1 NOTCH1 TPO WNT7B NODAL WNT1 WNT2 HGF TF IL6 NTF4 TNFSF11 FLT3LG GDF5 ALK INS;INS-IGF2 EGF EPO PDGFA KITLG WNT3A WNT5A CNTF FGF10 PDGFB WNT2B FST FGF2 LEFTY2;LEFTY1 IL11 NOG SHH CSF1R FGF1 IL3 CSF1 FGF4 INHBA FGF8 CXCR1 VEGFA KIT TGFB1 TGFB3 NT5E IGF1 CREATINE PATHWAY%WIKIPATHWAYS_20260910%WP5190%HOMO SAPIENS Creatine pathway GATM CKB GAMT OAT SLC6A8 CANCER PATHWAYS%WIKIPATHWAYS_20260910%WP5434%HOMO SAPIENS Cancer pathways ADCY8 RXRA STAT5A EGF FN1 PRKACB-1 ESR1 TXNRD3 CCND1 MYC RUNX1 ERBB2 HHIP GNAI3 PDGFB GNAI2 RPS6KA5 PTCH2 GLI2 SHH KIF7 IGF1 BMP4 BMP2 MAPK8 CASP8 FADD TPM3 GSTT2B;GSTT2 GSTM1;GSTM2-1 TGFBR1-1 MMP3 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 IL13RA1 FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 AKT2 AKT3 AKT1 MTOR AGTR1 GSK3B HDAC1 PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 EPAS1 RAC1 JAK2 LPAR2 LPAR3 IL6R LPAR4 GNG10 MAPK3 JAK1 NCOA1 GNG13 CREBBP STAT1 TXNRD1 LPAR5 BAD LPAR6 SPI1 STAT3 GNGT1 AGT MMP1 IKBKG RUNX1T1 KEAP1 IL6 IGF1R RPS6KB1 FRAT2 GRB2 SKP1 IL6ST SOS1 BCL2L1 VEGFB VEGFD TCF7 DVL1 CXCL8 DVL2 KITLG DVL3 CSF3R IL2 ESR2 IL4 IFNG SP1 PDGFRA F2R FLT4 IL12A COL4A2 PTEN COL4A1 BRCA2 COL4A4 POLK FZD10 APC2 COL4A6 NCOA3 FGF1 CSF1R AXIN1 SOS2 LEF1 EGFR HSP90B1 E2F2 HES1 E2F3 PRKCG BAK1 HES5 TCF7L2 TCF7L1 KLK3;KLK2 WNT5B PRKCB HEYL GNB2 APC PRKCA GNB1 RPS6KB2 GNB4 SMO GNB3 IL7R NOTCH2 NOTCH3 NOTCH1 HSP90AB1 LAMC3 NOTCH4 LAMC2 PIK3R3 LAMC1 HSP90AA1 WNT6 WNT1 WNT2 WNT4 JAG2 MST1 WNT10B WNT10A IL3RA CXCR4 SMAD4 FZD2 CXCL12 JAG1 LAMA5 FZD5 LAMA2 FZD4 TRAF3 LAMA1 FZD7 CCDC6 LAMA4 PTCH1 LAMA3 FZD6 FZD9 STAT4 SMAD2;SMAD3 FZD8 GNG2 IL12RB1 GNG5 IL12RB2 IFNGR1 FGFR4 GNG4 GNG8 FGFR3 IL23A FGFR2 LAMB3 FGFR1 LAMB2 WNT2B LAMB1 BCL2L11 PIK3CD EPOR PIK3CB GLI3 FASLG HEY1 HEY2 WNT9B WNT9A CDKN2A WNT16 PIK3CA PPARG RASSF1 LRP5 WNT8A PGF WNT8B DLL1 DLL3 DLL4 MAPK9 WNT11 WNT7B MAPK10 PPARD CTNNB1 RB1 CDKN1A CDKN1B BBC3 GLI1 FLT3LG CASP9 TFG CCND3 DAPK2 CCND2 DAPK3 EML4 CASP3 MECOM APPL1 FH MAX NKX3-1 PLEKHG5 APAF1 TRAF4 CCDC42 BIRC7 BIRC2 BIRC3 DDB2 RASSF5 RALGDS CCNE2 RASGRP2 CSF2RA RASGRP4 CCNE1 PLD2 RASGRP3 TP53 GNB5 MDM2-2 CKS1B CYCS-1 ARHGEF11 ARHGEF12 DCC DAPK1-1 ABL1 RALB ADCY1 E2F1 LAMB4 RBX1 PMAIP1 MSH6 BID CTBP2 MSH2 GADD45B MSH3 GADD45A PML GADD45G CDK6 ARNT2 RAD51 CDK4 CDK2 FAS BAX FOXO1-1 FLT3 IL2RG STAT6 TGFB2 IL4R TGFB1 ARNT TGFB3 NFKB1 MLH1 NFKB2 TGFBR2 TRAF6 IL2RA IL2RB GNA11 NTRK1 IL12B RET EDN1 HGF MMP2 IL13 IL5RA CSF2RB PLD1 CCNA1 VHL PDGFA TGFA TERT HMOX1 CDKN2B IL5 NFE2L2 PTGER4 PTGER2 CASP7 VEGFA EDNRA EDNRB PTGER1 PTGER3 ADCY3 CAMK2B GNAI1 CAMK2D NRAS IGF2 HIF1A CAMK2A HRAS CAMK2G RALBP1-1 GNAS-1 RALA-1 GNAQ KRAS PTGS2-2 BDKRB2 ALK ETS1 CRKL MET COL4A3 COL4A5 F2RL3 ELK1 IKBKB EP300 JAK3 CHUK FOS CEBPA CBL RELA CALML6 CALML3 CALML4 STAT5B NFKBIA EPO PDGFRB AXIN2 KIT CTBP1 EGLN1 EGLN3 EGLN2 PLCB3 PLCB4 PLCB1 PLCB2 JUN BCL2 RXRB RAF1 RXRG MGST3 MGST1 MGST2 NCOA4 AR GSTM4 GSTM3 TRAF2 ADCY4 ADCY2 ADCY7 ADCY6 NOS2 ADCY5 ADCY9 GSTO2 GSTO1 GNA13 GNA12 ARHGEF1 BCR PIM2 GSTP1 RASGRP1 KNG1 XIAP TRAF1 GSTA4 ITGA2B ARAF BIRC5 BDKRB1 BRAF PTK2 PIM1 ITGB1 CUL2 RAC3 ITGAV ELOC-1 ITGA3 ITGA2 ELOB JUP ZBTB16 ITGA6 SKP2 CRK ROCK1 ROCK2 CUL1 ZBTB17 IL15 IL3 CCNA2-1 IL7 HDAC2 TRAF5 CDH1 CTNNA1 CTNNA3 CTNNA2 IFNAR2 STAT2 IFNGR2 IFNAR1 RARA RARB PLCG2 F2 TPR MITF TXNRD2 SLC2A1 LPAR1 PLCG1 RHOA PRKACA-1 NQO1 VEGFC PAX8 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5102%HOMO SAPIENS Familial partial lipodystrophy MAPK9 ICMT LMNA ZMPSTE24 KLF9 SREBF1 LMNB1 FNTA CEBPA PNPLA2 INS;INS-IGF2 STAT5B LIPE BANF1 FABP4 AKT2 GATA3 GATA2 KLF2 KLF5 PPARA PRRX1 CIDEA CIDEC PIK3CA PPARG LMNB2 LPL PLIN1 MGLL BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260910%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment MAPK7 IKBKB PDPK1 MAPK11 CTNNB1 CHUK RAPGEF1 CASP9 CRK NFKBIA ROCK1 ROCK2 CDC42 PAK1 MYC APAF1 DOCK7 CREB1 ARHGDIA YWHAE TP53 YWHAB YWHAQ CYCS-1 YWHAH MKNK1 SMPD1 MAP3K3 ARHGAP35 TIAM2 PARD3 IQGAP3 NPTX2 WASL RND3 PARD6B LINGO1 SORT1 MAPKAPK2 KIDINS220 MAPK8 CASP8 BAX TRADD FADD MAP2K7 IRS1 EIF4E IRS2 BDNF EEF2K JUN MAP3K1 BCL2 EEF2 RAF1 AKT1 MAP3K5 MTOR GSK3B YWHAG YWHAZ MAP2K2;MAP2K1 MAPK1 RAC1 EIF4EBP1 TRAF6 MAPK3 NGFR MAP2K4 BAD PRKCD STAT3 GAB1 PTPN11 IKBKG RTN4R RPS6KB1 GRB2 SOS1 SHC1-1 TCF7 SH2B2 CFL1 BMP7 LEF1 PRKCG PRKCI TCF7L2 PRKCH TCF7L1 PRKCB PRKCE PRKCA RPS6KB2 NRAS PLCG1 PRKCZ HRAS RHOA KRAS PARD6A CFL2 STMN1 LIMK1 TIAM1 DIAPH1 FOXO3 BCL2L11 PIK3CD PIK3CB RAP1B PIK3CG TP73 FRS2 MAP2K5 NTRK2 PIK3CA REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling IRF3 MAPK9 CYLD MAPK14 MAPK12 MAPK13 IKBKB MAPK10 MAPK11 CHUK FOS RELA NFKBIA PTPN6 PLK1 TNF IFNB1-4 IRAK1 IRAK2 MAP3K8 TOLLIP TAB3 CXCL11 TAB2 TAB1 MYD88 IL1B USP7 FBXW5 CD180 TRAFD1 RNF41 MAPK8 SIGIRR RBCK1 CASP8 LY96 RNF216 CUEDC2 SFTPD RIPK1 IRAK3 FADD MBL2-1 TICAM1 PELI1 ZMYND11 RNF31 MAP2K7 PELI3 PELI2 CTNNAL1 MAP2K6 SARM1 MAP2K3 JUN IFNAR2 CCL5 AKT2 AKT3 CD86 AKT1 TMED7 CD80 IFNAR1 SOCS1 CISH PIK3R2 PIK3R1 IRAK4 NFKB1 MAP2K2;MAP2K1 NFKB2 MAPK1 RAC1 CXCL10 TRAF6 MAP3K7 MAPK3 MAP2K4 STAT1 IL12B IKBKG LBP IL6 CCL3L1;CCL3L3;CCL3;CCL18 SYK BTK CXCL8 CCL4L2;CCL4L1;CCL4 TICAM2 SPP1 TIRAP TLR1 TLR9 TLR8 TLR6 IL12A TLR7 TLR4 TLR3 CXCL9 IRF7 SQSTM1 PIK3R3 CD14 PIK3R5 TRAF3 CD40 TIFA TNFAIP3 TREM1 TLR5 TLR2 MLST8 PIK3CD PIK3CB PIK3CG IRF5 SMAD6 TBK1 OTUD5 PIK3CA IKBKE ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment CHUK IKBKG IL6 RELA MUC1 NFKBIA TNF NFKB1 IKBKB NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260910%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY6 LPAR4 ADORA1 P2RY4 ADORA2B P2RY2 ADORA3 P2RY1 LPAR6 LTB4R ADORA2A OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260910%WP3287%HOMO SAPIENS Overview of nanoparticle effects CDH3 PTGS1 HMOX1 BAX COL4A1 PIK3CD TNF AKT3 ITGAD IL6 CRP PTGS2-2 PTK2 NFRKB CCND3 LAMA3 FN1 BCL2 CXCL8 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260910%WP4564%HOMO SAPIENS Neural crest cell migration during development NGFR CDH11 PIK3R4 PIK3R3 STAT3 PIK3R6 PIK3R5 RHOA FOS MMP2 BDNF TRIO JUN MMP9 EPHB6 EPHB1 EPHB3 NGEF MMP8 BUB1B-PAK6;PAK6 PAK1 PAK5 PAK3 PAK2 PAK4 TIAM1 EPHB2 PIK3CD AKT2 AKT3 PIK3CB AKT1 EPHB4 F2RL2 PIK3CG PIK3CA ARF1 RAC1 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer GOT1-1 SLC2A1 SLC1A5 HK2 BCKDHA GLS2 LDHA PKM HK1 SLC16A1 GLUD1;GLUD2 DLAT SLC7A5 KRAS CARM1 DLD UAP1 PDHB BCAT2 FASN SLC43A1 LDLR PDHX ME1 PGM3 HMGCS2 SLC16A4 GPT RPIA PFKL SOAT1 PDHA1 RPE;RPEL1 ACLY GNPNAT1 TP53 GFPT1 HMGCR CS MDH1 GOT2-1 GPI LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260910%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB3L2 IL1B CREB1 MAPK14 CD14 MAPK12 TLR4 MAPK13 ATF4 MAPK11 CCL13;CCL2 IL6 REL RELA CREB3 CREB3L3 RELB CREB3L4 CREB5 CREB3L1 IL10 NFKB1 NFKB2 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260910%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 PRKAA1 ADIPOQ LEPR ACACA PRKAG1 ADIPOR1 ADIPOR2 LEP CPT1A SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260910%WP15%HOMO SAPIENS Selenium micronutrient network SCARB1 SERPINA3 SERPINE1 PLAT FLAD1 TXNRD1 MTR-1 RFK MPO GPX6 ICAM1 SAA2;SAA1 CBS;CBSL FGB PRDX1 FGA SAA2-SAA4;SAA4 FGG IL6 APOA1 F2 RELA F7 PLG HBD;HBB LDLR ABCA1 TXNRD3 INSR MTHFR SOD2 SOD3 SOD1 IFNG HBA2;HBA1 CTH ALB TNF PNPO KMO CAT XDH KYNU TXNRD2 IL1B PTGS1 ALOX5 ALOX15B ALOX5AP GPX1 GPX4 PTGS2-2 GSR INS;INS-IGF2 APOB GGT1 SEPHS2 SELENOO SELENON SELENOS SELENOT SELENOK SELENOI PRDX3 SELENOP PRDX2 PRDX5 PRDX4 DIO1 DIO3 CCL13;CCL2 CRP NFKB1 TXN NFKB2 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL1RL1 IL13RA1 IL4 STAT3 IL33 TSLP IL5 FCER1G TYK2 IL31RA JAK3 FCER1A DEFB103A;DEFB103B IL2RG MS4A2 OSMR CRLF2 STAT6 IL13 IL4R IL25 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260910%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases SMAD2;SMAD3 PPP3CA NFATC1 RXRA MAPK14 TNF MED14 VDR IKBKB DUSP1 CHUK IKBKG PPP3R1 IL6 SMAD4 RELA MAP2K6 MAP2K3 NR3C1 MAP3K1 NFKBIA NFKB1 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome TJP3 TJP2 PRKAA1 CTNNB1 TJP1 GJA1 FMO5 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PRKAB2 PRKAB1 F11R GJA3 KIRREL1 AMELY;AMELX ACP6 GJA5 OCLN-1 GJA8 CHD1L PYGO1 PYGO2 BCL9 AFDN CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260910%WP2023%HOMO SAPIENS Cell differentiation expanded index RUNX2 MEF2A MEF2B;BORCS8-MEF2B KLF4 TLX3 TLX2 MEF2D PAX7 ID2-1 TLX1 LEFTY2;LEFTY1 STAT3 EZH2 HDAC5 SOX2 MEF2C MYOD1 SRF PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260910%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing IRF3 RNASEH2C RNASEH2B RNASEH2A MAVS TREX1 RNASEL RNASET2 STING1 ADAR SAMHD1 IFNB1-4 OAS1 CGAS IFIH1 DDX58 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies IL2 F2RL1 IFNG ITGB7 ITGA4 TNF DHODH IL15 CD4 EGFR IL21 GZMH;GZMB-1 TGM2 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260910%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer SLC2A1 SLC1A5 PYCR2 LDHA GLS GAPDH-1 PGAM1 PKM PGK1 ENO1 PSPH HK3 PYCR1 SLC16A3 IDH3A IDH2 TIGAR TALDO1 PAICS GLUD1;GLUD2 G6PD ACO2 TKT PSAT1 SHMT2 PDHB SDHB FASN FH DLST RPIA PFKL ALDOB PDHA1 ACLY SUCLG2 MDH2 GOT2-1 GPI PGD NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260910%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway DEPTOR ATG16L1 PLA2G6 PRKAA1 MECP2 ATG101 FTL-1 PIK3R4 RHEB WDR45 RB1CC1 DCAF17 C19orf12 ACACA WIPI1 GTPBP2 WIPI2 CP COASY FA2H BECN1 ATP13A2 RPTOR STK11 ATG14 ATG13 TSC2 SCP2 MLST8 ULK1 SPTLC1 MTOR MAP1LC3A TSC1 ATG3 ATG10 ATG12-1 ATG2A AKT1S1 PIK3C3 ATG4A ATG7 ATG5 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260910%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis PRKCA CAMK2B CAMK2A NRXN3 NRXN2 MAPK14 PPARGC1A RPS6KA1 NRXN1;NRXN3;NRXN2 NGF BDNF CAMKK2 CCND2 HNRNPL BCL2 CAMKK1 SYT2 SYT12 DRD1 CREB1 RPS6KA5 CAMK4 PRL NCAM1 CALM1 MAPK1 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260910%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSG ACE CTSD CMA1 REN MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260910%WP2003%HOMO SAPIENS miR targeted genes in leukocytes WDR11 LAMTOR3 TUSC2 PKM ARID4B MAPK14 CTNNB1 WDFY1 MATR3 SLC1A4 CORO1C RAB6A ANAPC1 CD164 SLC25A1 SNAP23 TNFAIP2 TMEM109 ACP2 SCYL1 GNAI2 ARHGDIA RFT1 YWHAQ MAP3K8 PDLIM5 CDK6 TUBA1A ACAA2 ARF4-1 ZEB1 SRSF10 CDIPT ANXA2 TPM3 G6PD GOLGA7-1 TNFSF9 IDH1 RAB34 TMED10 ADIPOR2 MRPL20 BCL2 ANPEP DDX5 ATP6V1F TBCA HNRNPM TRAM1 ADAR RDH10 MRC2 SPTLC1 SH3BGRL3 USP1 SEC24A PPIF CAPG PRPF40A POM121;POM121C PPIB PNP-1 POLE4 IFRD1 DNAJB1 POLR2C RTN4 TXNRD1 CAP1 PHC2 AP3D1 ARCN1 IGF2R CSRP1 FMNL2 GYS1 ATP6V0E2;ATP6V0E1 PLXND1 SLC7A11 ATP2A2 TXN2 CEBPB SERPINE2 C1orf56 DCAF7 KCNN4 TMEM43 SAC3D1 HMOX1 ADPGK PRSS21 PTRH1 UNC93B1 GNA13 NELFCD MCL1 TYMS CHORDC1 CDK5RAP1 MTHFD2 VPS39 CDK5RAP3 ATP6V0A1 SNX6 SFXN1 PTPA FADS1 RAB5C PISD TMED3 CTSC BCL6 RHOG GAK THBS1 SLC7A6 CDCP1 FRG1 BRPF3-1 MPDU1 LMNB2 LPL SHOC2 CA12 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260910%WP5496%HOMO SAPIENS Targeted therapy in breast cancer MAPK3 NRAS PIK3R4 ERBB3 PIK3R3 ERBB4 HRAS PIK3R6 PIK3R5 KRAS RAF1 ERBB2 PIK3CD AKT2 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A PIK3CG PIK3C2B EGFR PIK3R2 PIK3R1 PIK3CA MAPK1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260910%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway ITGB2 C1QC RAC3 PLCG2 PIK3R3 VAV3 PIK3R6 FCGR1A VAV1 VAV2 HCK NCF2 TREM2 LYN SYK PTPN6 C1QB TREM1 NCF1 TYROBP LAT ARPC1B NCF4 PIK3CD SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 CYBA PIK3CB FCER1G PIK3C2A PIK3CG CYBB PIK3R2 PIK3R1 PIK3CA NCKAP1L PIK3C3 ITGAM RAC1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260910%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOA4 APOA5 LIPC APOC2 SCARB1 CYP7A1 PLTP FDFT1 APOA1 MTTP APOE APOB LDLR ABCG8 ABCA1 ABCG5 SQLE APOC3 SOAT1 DGAT1 ACSS1 APOC1 PDIA2 HMGCR CETP LRP1 APOA2 LPL LCAT PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260910%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma KDM6A CREBBP ARID4B EP300 SMARCE1 CEBPA BRCA1 CHEK2 CHEK1 MAX TLK1 MYC ERBB2 SMC1A ARID5B FGF16 PTEN ARID1A TP53 JMJD1C MYB NCOR1 MYBL1 CMTR2 UHRF1 MAGI1 BRD1 INSRR IL17RD MORF4L1-2 FOXP2 MYCN KAT6A CTBP1 MAML3 DTX4 FBXW7 CNTN6 MGA MYCBP-1 H2AC16;H2AC11 H1-4 KANSL1 NFIB NOTCH1 KMT2C PRKDC KDM6B HRAS ATM BCOR SRCAP RAF1 NSD1 FGFR4 SMARCA2 ERBIN FOXO3 AKT1 BCORL1 ATRX MAGI2 PIK3CA MAP2K2;MAP2K1 SETD2 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260910%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC22A2 SLC31A1 HEART DEVELOPMENT%WIKIPATHWAYS_20260910%WP1591%HOMO SAPIENS Heart development BMP4 BMP2 GATA6 TBX20 BMP10 NKX2-5 NOTCH1 IRX4 TBX2 HAND2 TBX5 ERBB3 FOXC2 FOXC1 PITX2 PTPN11 GATA4 HAND1 NFATC2 CTNNB1 SMAD1 SMAD4 VEGFB FOXA2 SMYD1 TBX1 NFATC1 BMPR1A FGF10 BMPR2 FOXH1 SHH BHLHE40 HEY1 VEGFC HEY2 FGF8 VEGFA MEF2C NFATC3 ISL1 NFATC4 MAPK1 SRF NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260910%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation IL1B PYCARD CASP1 CTSB TLR4 NFKB1 NOX1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260910%WP4146%HOMO SAPIENS Macrophage markers CD68 F3 CD74 CD163 CD14 CD83 LYZ-1 CD86 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260910%WP4504%HOMO SAPIENS Cysteine and methionine catabolism GOT1-1 CSAD AHCY MTR-1 CTH CDO1 MPST SQOR CBS;CBSL SUOX BHMT ETHE1 MAT1A GSS GCLC SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260910%WP4496%HOMO SAPIENS Signal transduction through IL1R MYD88 TRAF6 MAP3K7 IL1B MAPK8 MAPK14 IKBKB IRAK3 CHUK IL1RN IL6 RELA MAP2K6 MAP2K3 JUN MAP3K1 NFKBIA IL1A IL1R1 ECSIT TNF IFNB1-4 IL1RAP IRAK1 IRAK2 TGFB2 TGFB1 TGFB3 TOLLIP NFKB1 TAB1 MAP3K14 TRANSLATION FACTORS%WIKIPATHWAYS_20260910%WP107%HOMO SAPIENS Translation factors EIF4EBP1 EEF1A1 PAIP1 EIF4EBP2 EIF2S1 EIF2S2 EIF4G1 EIF2S3;EIF2S3B EIF1 EIF4A2 EIF3C;EIF3CL GSPT2 EIF5 EIF4H EIF4E EIF3I EIF2B1 EIF1AY;EIF1AX EEF2K EEF1B2-1 EIF3J EIF2B5 EIF3G EIF2B4 EIF3H EIF5B EIF3E EIF2B3 EIF3F CLUH EIF3D EIF5A;EIF5AL1 EIF3A EEF1G EIF3B EEF2 EIF6 EEF1D EIF2B2 EEF1A2 ETF1 PABPC1;PABPC3 EIF4G3 EIF4B EIF2AK1 EIF2AK3 EIF2AK2 EIF4A1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260910%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling MAPK9 MAPK7 PRKAA1 MAPK14 VAV3 ELK1 IKBKB PDPK1 MAPK10 EIF2S2 CTNNB1 CHUK VAV2 RELA PRKAA2 STAT5A STAT5B NFKBIA CASP3 SRC CDC42 CREB1 RAB3A YBX1 RPS6KA5 CAMK1 NSF IGF2BP1 GRIN2B RASGRF1 LINGO1 SORT1 CDK5 KIDINS220 GRIA3 MAPK8 CRTC1 RPS6KA3 RPS6KA1 MAPT IRS1 EIF4E IRS2 BDNF NCF2 JUN MAP3K1 ACACB PPP2CB;PPP2CA EEF2 RAF1 CDKL5 GRIN1 TSC2 CDK5R1 SYN1 FYN AKT1 MTOR ADAM17 GSK3B RPS6 PIK3R2 PIK3R1 NFKB1 MAP2K2;MAP2K1 MAPK1 SIRPA;SIRPB1;SIRPG RAC1 JAK2 EIF4EBP1 RACK1 TRAF6 MEF2A NCK2 MAPK3 NGFR MAP3K2 STAT1 NTRK1 BAD PRKCD NTRK3 STAT3 EIF2S1 PTPN11 IKBKG CDH2 RPS6KB1 GRB2 SHC4 SHC1-1 SHC2 SH2B2 CFL1 NCF1 CSNK2A1;CSNK2A3 PTK2B GABRB3 MEF2C SQSTM1 NFATC4 APC GRIP1 CYFIP1 GRIA1 PLCG1 CAMK2A GRIA2 HRAS NGF DLG1 CNR1 NCK1 DPYSL2 FRS3 DOK5 KCNN2 TIAM1 DOCK3 KCNA3 PTPRF NTF3 SH2B1 RANBP9 FOXO3 MARCKS CAMK4 SHC3 RHOG RAP1A FRS2 MAP2K5 KSR1 NCAM1 NTRK2 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260910%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction ACE2 IFNAR1 TNFRSF1A ICAM1 TNF NFKB1 NOX1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C18-1 CYP2B6 CYP2C9;CYP2C19 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260910%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis MED15 NR1H3 SREBF2 PRKAA1 SCD PPARGC1A SIRT1 MTOR HMGCR HMGCS1-1 SREBF1 SIRT6 PPARA FASN LDLR ABCA1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260910%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC3 SLC51A SLC51B ABCC4 SLC10A1 ABCC2 ABCB11 SLC10A2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FABP6 ABCB1 NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP61%HOMO SAPIENS Notch signaling JAK2 DLL1 PSEN1 DLL3 DLL4 NCOR2 SNW1 STAT3 EP300 NUMB NUMBL SKP1 SRC CUL1 ITCH APH1A RBPJ NCSTN NCOR1 APH1B FHL1 HES1 HES6 HES5 MAML3 FBXW7 TLE1 HDAC2 NOTCH2 NOTCH3 NOTCH1 PSENEN NOTCH4 JAG2 JAG1 LCK MAML2 MAML1 AKT1 CIR1 MTOR RING1 SAP30 DTX1 ADAM17 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 HEY2 SPEN GSK3B HDAC1 PIK3R2 PIK3R1 PSEN2 NFKB1 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260910%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A1 GCG IL6R IL6 GLP1R SLC2A2 INS;INS-IGF2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260910%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets TCF4 RUNX2 CSF2 TPO ID2-1 SPI1 STAT3 CSF1 IRF4 IRF8 BATF3 FLT3LG IKZF1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260910%WP400%HOMO SAPIENS p38 MAPK signaling RASGRF1 MAP3K7 MAPKAPK2 MAP2K4 STAT1 MAPK14 ATF2 HRAS TRADD ELK1 PLA2G4A RIPK1 MAP3K9 MAP2K6 GRB2 TRAF2 MAP3K1 TGFBR1-1 DDIT3 SHC1-1 MAX CDC42 MYC MEF2D CREB1 RPS6KA5 MAP3K5 HSPB1 DAXX MKNK1 TGFB2 HMGN1 MAPKAPK5 SMIM40 RAC1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260910%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling WDR74 SKAP1 CFP BTN3A1;BTN3A3 APOM APOH HP;HPR VPS11 TPO VPS16 INTS4 TOMM70 HRG CTSZ UPF1 SDF2 GP1BA ATP13A3-1 IL16 OS9 SERPINA5 SRP72 MIB1 FOS LRG1 ACTG1 CCL27 RHEB CCL26 RRM2-1 SRP19 STEAP3 CLCC1 TLE3 VPS33A ADAM9 G3BP1 FN1 G3BP2 CFB NPTX1 PTPN6 MDN1 FAM83A NEK9 HSPA8 C1S GGH C1R TP53I3 CFI PF4;PF4V1-1 LGALS3BP ATG13 TRO SELP LARP1-1 TRIM59 SRP54 ITIH4 ITIH3 ULK1 RAP1GDS1 FGF2 ERLEC1 TNF CCL8 CXCL13 UGGT2 ATE1 C8A ACTB-1 COL7A1 VPS41 FAM98A CFH-3 IRAK1 CXCL2;CXCL3;CXCL1-1 CCL21 MYD88 IL1B MAPK8 CASP8 CD226 CCL22 MMP25 EIF4E JUN BST2 IFITM3;IFITM2;IFITM1 LCK CD8A CD8B;CD8B2 MOV10 AKT1 MTOR ACE2 SIGMAR1 CRP DDIT4 GTF2F2 RAC1 JAK2 JUNB JAK1 RTN4 STAT1 CD3G PRG3 CD3E DUSP1 CD2 NKRF AGT IKBKG CD247 LBP IL6 RRAS TRAF2 IL10 CARD11 CCL11 CXCL8 IL18 IL4 IL1A IFNG IL12A ITCH IGFBP3 TLE1 PRKCQ CD14 SMAD1 IL21 IL22 CXCL12 TRAF3 IL18RAP SMAD5 BIRC5 IFI44L IFIH1 TBK1 IGLL5;IGLL1 DDX58 IRF3 TRPM2 MAVS CASP5;CASP4 TBKBP1 ITGA3 CASP9 EGR1 CASP3 APOD CCR6 CCL1 IL33 CCL20 IFNB1-4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 CCNB2 IL7 CCNB1 HLA-DRA APOL3;APOL4;APOL1;APOL2 BID CDK1 CCL23;CCL15 PARP2 ATP6AP1 NLRP1 CCL5 IFIT1 FYN PIAS1 MX1-1 IRF9 CCL13;CCL2 CTSD RPS6 ZAP70 NFKB2 TGFBR2 CXCL10 EIF4EBP1 TRAF6 SERPINE1 NTRK1 SAA2;SAA1 FGB FGA FGG APOA1 IL13 CCL3L1;CCL3L3;CCL3;CCL18 HBD;HBB CEBPB C1QBP CCL4L2;CCL4L1;CCL4 IL9 PMPCB ALB IL5 APOC1 CXCL9 IL1R2 AHR PITRM1 MAP1LC3B2;MAP1LC3B-1 NLRP3 GABARAPL2 NFATC3 IL17A DEPTOR HIF1A CTSB CD163 GSN EIF4A2 TF PTGS2-2 CPN1 CTSV;CTSL RPTOR MARK2 CCR5 MLST8 CAMK4 CXCR1 CXCR2 TNFSF10 CXCL5;CXCL6 AKT1S1 GTSE1 APOA2 VPS36 VPS18 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer SMARCD1 SMARCD2 SMARCD3 HSD17B2 SMARCC1 SMARCC2 ACTL6A MAPK14 ARID1B ELK1 RB1 CDKN1A CDKN1B FOS MRE11 RHEB RAPGEF1 BRCA1 ERG CASP9 CDC25B CRK DOCK1 CHEK2 CASP3 CHEK1 CCND1 PAK1 MYC CDC25A PLK1 ARID1A TP53 MDM2-2 F13B SPINK1 FKBP5 BLM BARD1 E2F1 NOXA1 MSH6 RICTOR SPRY1 MSH2 RASA1 RAD50 CDK4 CDK2 CDK1 MAPK8 CASP8 BAX ATM SPRY2 ATR HSD17B7 FOXA1 ABCC4 JUN BCL2 RAF1 TSC2 SMARCA4 AKT1 MTOR ETV4 MAP2K2;MAP2K1 MAPK1 EIF4EBP1 MAPK3 JAK1 AR STAT1 BAD STAT3 GAB1 PTPN11 MMP1 HGF GRB2 SOS1 SP1 PTEN CDKN2B EIF4E1B HSD17B4 HSD17B1 PTK2B KLK3;KLK2 CYP17A1 PRKDC HRAS MAP4K1 CPN1 CRKL SMAD2;SMAD3 RPTOR ATF1 HSD17B3 HSD3B1;HSD3B2 ACTL6B PXN RAP1B TSC1 RAP1A NDRG1 CDKN2A PIK3CA ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2853%HOMO SAPIENS Endoderm differentiation GATA6 CEBPZ VAV3 CTNNB1 HPRT1 APP ZFHX4 NKX2-1 SESN1 ZBTB17 GLI2 HNF1B PAX3 SOX17 CER1 CAND1 SFRP1 WWC1 TOX3 HOXA1 CTBP2 SFMBT1 CDYL MAD2L2 RFX7 RAB38 NAA15 CTR9 TCF4 PRDM14 RTF1 ELK4 SIAH2 PBX1 FOXN3 DAB2 SP4 PAF1 TAF4B LHX1 ONECUT1 HOXC11 CDC73 CRTC1 EZH2 HHEX DUSP4 DUSP5 DUSP2 NME1 FOXA1 PAX9 BTAF1 LEO1 KDM4A SOX2 LRPPRC TNRC6C NR3C1 MAP2K3 FOXO1-1 ACACA FOXA2 PABPC1;PABPC3 SOX21 CEP250 RARG DIP2A WNT3 EOMES WDHD1 ZNF281 PIAS1 EMSY TOX WDFY2 BCORL1 MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 GDF3 TGFB1 TRERF1 NLK NABP2 TRIM71 NCAPG2 PHF6 ZIC3 TRIM5 DKK1 JARID2 SLC2A12 TET1 STAT1 PARP8 TAF5 DDAH1 CUL4B PLCH1 AEBP2 MTF2 GATA4 AHDC1 ASCC3 ZNF462 ELP4 OTX2 GRHL2 SOX7 RGS10 TCF7 C1QBP BMP7 EXT1 LEF1 TCF7L1 APC POU5F1;POU5F1B NOTCH1 NANOG;NANOGP8 LAMC1 ELAVL1 DNMT3B MIXL1 NODAL BPTF SMAD4 TBX21 SMAD2;SMAD3 BMPR1A NOG FOXH1 WNT8A PTHLH SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260910%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TRAF6 IRF3 TBK1 TOMM70 MAVS TRAF3 IKBKE IFNB1-4 DDX58 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 RAF1 ZP2 LMNA POR PTPMT1 MDH2 HSPB1 YWHAG TMEM120B RHBDD2 ZP3;POMZP3 SFN TMEM120A SSC4D DAPK2 STYXL1 G3BP1 KIF1C ZP1 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260910%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 NOS1 HBA2;HBA1 NOS3 XDH HBD;HBB MB AOX1 NRF2 ARE REGULATION%WIKIPATHWAYS_20260910%WP4357%HOMO SAPIENS NRF2 ARE regulation PRKCA PGAM5 GSTA3;GSTA5;GSTA1;GSTA2 GCLM INSR NQO1 HMOX1 MAPK8 MAF FYN EPHB2 YES1 NFE2L2 KEAP1 CUL3 SLC7A11 GSK3B RBX1 PIK3CA CEBPB GCLC SRC AIMP2 ROTENONE METABOLISM%WIKIPATHWAYS_20260910%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway S100P CPEB4 ZIC2 ANKRD1 LRRC8A ANGPTL4 RXRA NR1I3 CDKN1C NR1I2 SNAI2 CUL1 PDE4B BIRC2 BIRC3 B3GNT5 IL11 CCL20 SLC19A2 SPRY1 GADD45B POU5F1;POU5F1B ETNK2 HSP90AA1 ALOX5AP PTGS2-2 NR3C1 ACKR3-2 JUN TNFAIP3 AKAP13 EPB41L4B ARL5B THBD RGS2 ENC1 TNS4 SRGN FGFBP1 DNER EDN2 TSC22D3 SERPINB9 NAV3 ADGRF4 CDC42EP3 TGFBR3 SCNN1A PMP2 MFGE8 CCL13;CCL2 PTGES3-1 BHLHE40 SLC26A2 ABHD2 PRRG4 FGD4 SEC14L1 GPR153 SERTAD2 STOM AMIGO2 MGAM PPP1R14C CAVIN2 PLK2 DNAJC15 NFKB2 KTN1 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260910%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells FMO3 CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 AOX1 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260910%WP5061%HOMO SAPIENS Fatty acid transporters FABP2 FABP9 ACSL6 ACSL5 FABP1 FABP3 FABP5 FABP4 FABP7 ACSL1 ACSBG2 ACSBG1 SLC27A4 CD36 FABP6 ACSL3 ACSL4 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260910%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy PFKFB2 SLC2A1 SLC1A5 LDHA MAPK3 GLS PKM PGLS PPARGC1A TRAP1 SLC16A1 SLC16A3 CPT1A RPS6KA3 RPS6KA2 RPS6KA1 DLAT G6PD GPX4 DLD GSR MITF RAF1 ARAF RPTOR LDHB PDHA1 MLST8 PKLR ACSS1 MTOR NAMPT BRAF MAP2K2;MAP2K1 MAPK1 SPINAL CORD INJURY%WIKIPATHWAYS_20260910%WP2431%HOMO SAPIENS Spinal cord injury PLA2G5 PLA2G6 PLXNA2 RB1 CDKN1B FOS GJA1 LGALS3 ROS1 EGR1 CASP3 ROCK2 C1QB CDC42 CCND1 MYC VIM SELP CD47 AIF1 TNF TP53 MBP SOX9 E2F1 RGMA OMG CXCL2;CXCL3;CXCL1-1 NTN1 E2F5 GADD45A NOX4 MAG IL1B PPP3CA CDK4 PLA2G2A-1 GDNF CDK2 CCNG1 CDK1 BDNF NR4A1 MMP12 GRIN1 NOS1 IL1R1 LTB4R CCL13;CCL2 SLIT2 TGFB1 MAPK1 RAC1 CXCL10 MAPK3 RTN4 CHST11 NGFR APEX1 RHOB ZFP36 SEMA6A MIF ICAM1 PDYN BCAN KLK8 LEP LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 BTG2 CCR2 NCAN RTN4R TNFSF13B ANXA1 IL6 TACR1 RHOC VCAN LTB ACAN MMP9 SLIT1 AQP1 SLIT3 XYLT1 C5 CXCL8 GAP43 NOS2 IL2 GFAP IL4 IL1A IFNG COL4A1 TLR4 EGFR PRKCA EPHA4 EFNB2 RHOA PTGS2-2 PTPRA FOXO3 COL2A1 PTPRZ1 FKBP1A CSPG4 AQP4 ARG1 INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260910%WP4558%HOMO SAPIENS Interferon mediated signaling PRKCA JAK2 IFNE IFNGR1 IFNK IFNAR2 JAK1 STAT2 IFNGR2 IFNG STAT1 IFNB1-4 IL10RB TYK2 IRF9 IFNAR1 PIK3R1 PIK3CA IFNLR1 IFNL2;IFNL3;IFNL1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260910%WP47%HOMO SAPIENS Hedgehog signaling SMO GRK2 PTCH2 DHH IHH GLI2 KIF7 SHH GLI3 SIN3A GLI1 ARNTL PTCH1 STK36 SAP18 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260910%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAPK3 MAP2K4 YAP1-1 PDK1 AKT1 MTOR RHOA GNAQ MAP2K5 MAP2K7 MAP2K6 MAP2K3 TRIO PIK3CA NFKB1 MAP2K2;MAP2K1 AMOT MAPK1 RAC1 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260910%WP3871%HOMO SAPIENS Valproic acid pathway IVD EHHADH-1 CYP2B6 HDAC1 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 ABAT HSD17B10 ACADSB HADHA CYP2C9;CYP2C19 ACSM1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260910%WP3935%HOMO SAPIENS Leptin insulin signaling overlap SOCS2 JAK2 INSR IRS4 DGKZ PIK3R3 STAT3 PDPK1 LEP AKT1 PIK3CG SOCS1 IRS1 IRS2 LEPR INS;INS-IGF2 SOCS3 AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260910%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension HAL UROC1 AMDHD1 GPT2 GLUD1;GLUD2 FTCD CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy CAVIN1 AGPAT2 BSCL2 LPIN3 DGAT2 DGAT1 HIF1A GPAT3 FYN AKT2 IRS1 CAV1 GRB2 PIK3CA LPIN1 INS;INS-IGF2 LPIN2 ITGB4 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAPK9 ANGPTL8 MAPK7 PRKAA1 MAPK6 RXRA MAPK4 MAP4K5 MAPK14 MAPK12 MAPK13 PDPK1 MAPK10 MAPK11 RHEB RAPGEF1 CBL PRKAA2 PRKAG1 CRK PRKAG2 PRKAG3 PRKAB2 PRKAB1 RPS6KA5 MAP3K8 RICTOR MAP3K3 GSK3A MAP3K14 NR1H3 MAPK8 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RPS6KA3 RPS6KA2 RPS6KA1 SREBF1 MAP3K9 MAP2K7 IRS1 EIF4E MAP3K4 IRS2 MAP2K6 MAP2K3 FOXO1-1 INS;INS-IGF2 MAP3K1 FASN ABCG8 ABCG5 MAP3K10 RAF1 MAP3K11 SREBF2 SCD TSC2 IRS4 AKT2 AKT1 CBLC MAP3K5 MTOR RPS6KA4 MAP3K6 GSK3B PIK3R2 PIK3R1 MAP3K13 MAP2K2;MAP2K1 MAPK1 FLOT1 FLOT2 EIF4EBP1 MINK1 CBLB MAP3K7 PTPN1 RHOQ MAPK3 CYP2B6 MAP2K4 MAP3K2 CAP1 MAP3K12 GYS1 RPS6KB1 SOS1 SHC1-1 SHC2 INSR SESN3 MAPKAP1 EXOC7 TRIP10 SOS2 SLC2A1 RPS6KB2 CYP7A1 PIK3R4 PIK3R3 HRAS MAP4K3 MAP4K4 MAP4K1 MAP4K2 THRB THRA PCK1 SLC2A4 RPTOR FBP1 RPS6KA6 MLST8 SLC16A2 FOXO3 PIK3CD PIK3C2G SHC3 PIK3CB G6PC1 PIK3C2A PIK3CG TSC1 MAP2K5 SLCO1C1 PIK3CA PIK3C3 LPL CILIARY LANDSCAPE%WIKIPATHWAYS_20260910%WP4352%HOMO SAPIENS Ciliary landscape MCM2 CD2BP2 BBS9 BBS7 CEP97 ECHS1 CEP290 BBS5 ANKS6 PSMD8 NEK8 BBS2 PSMD7 BBS1 TTC8 VIM MCM10 CALM1 SNRPB2 RNGTT LRPPRC RHBDD2 PSMC6 PSMC4 ZYG11B HDAC1 PSMD12 POM121;POM121C STOM EXOSC4 PSMD13 RAC1 CREBBP RAB8A DVL3 AGPAT2 RAB2A EXOC7 TRAF3IP1 SMC4 COX6C ARMC8 IFT88 MYL6 INTU COPS7B COPS7A IQGAP1 IQGAP2 CDR2 AAR2 CTSA EXOC6B BBIP1 AIMP1 EHD3 WNK1 RANBP10 GDI1 APC MYL6B TNKS1BP1 TMED1 CNOT6L EIPR1 RAB3IL1 NME8 EXOC4 EXOC3 EXOC5 MAPRE2 EXOC1 YAP1-1 WDR26 EXOSC7 PGRMC2 EXOSC9 EXOSC2 WHRN UBE2D3;UBE2D2 TIPRL-2 MKLN1 GID4 GID8 YPEL5 DGKE MAEA APMAP LZTFL1 TTC30A;TTC30B LCN2 ERF ARL8B SPATA7 CDH23 UBE2H TFAP2D FUZ CNOT10 LSM4 IFT20 COPS4 COPS3 COPS5 CNOT1 COPS2 COPS8 TFAP2E;TFAP2B TTC26 ZMYND19 MCM8 RAB14 MCM9 RPGR IFT52 IFT57 IQCB1 RBM14 ARFGAP3 RABEP2 SSNA1 EFHC2 CCDC40 VPS4A USH1C EHBP1 RAB21 RMND5B DNPEP RMND5A DCAF11 LCA5 MFAP1 VAPB CLUAP1 CTNNB1 TFAP2A RB1 TFAP2C UQCC1 CNOT9 MKS1 DOCK5 SNAP29 ARHGDIA NEK7 RALB CTBP2 MSH2 IQGAP3 H3-3A HDAC2 GLB1 ACSL3 NEFL DDX5 PAFAH1B1 COPS6 NFKB1 BBS4 NDUFA9 NUP133 NDUFA5 NEFM CBS;CBSL MCM7 MCM3 NUP88 MCM4 MCM5 MCM6 IFT172 DCAF7 IFT74 AFG3L2 WEE1 HTRA2 GLA CAMK2A XPNPEP3 EXOC8 EXOC2 DYNC2I2 DYNC1H1 EIF5B DYNC1I2 DYNC2I1 DYNLT1 NUDC IFT140 DYNLT2B IFT122 IFT80 HSPB11 DYNC1LI1 IFT22 IFT43 IFT81 RANBP9 IFT27 DYNLRB2 DYNLRB1 IFT46 EXOC6 EFTUD2 TBC1D4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260910%WP1993%HOMO SAPIENS Angiogenesis overview NRP1 MAP3K7 ROBO4 MAP2K4 SHB ROBO1 TIMP4 BAD WAS MAPK14 ATF2 BMX ELK1 PDPK1 PTPN11 MAPK11 PLXND1 DOK2 SEMA4A MMP2 F2 GRB2 DAG1 MMP9 SOS1 CRK SHC1-1 VHL SRC CDC42 PAK1 KDR FGF1 PTK2B IQGAP1 VEGFA NOX4 APC PRKCA GRB14-1 GRB7 SEMA3A MAPK8 PLCG1 PLA2G1B KRAS MAP2K6 NCK1 RAF1 MMP14 NOS3 FGFR1 TIMP2 PIK3CD AKT1 PXN MTOR ANGPT1 FRS2 TEK SLIT2 MAP2K2;MAP2K1 MAPK1 RAC1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5365%HOMO SAPIENS 4p16 3 copy number variation H3-3A MAPK3 PLCG1 SLBP GAB1 NSD2 CLTCL1 TMEM129 FAM53A POLN CKAP5 LETM1 TACC3 C4orf48 CBL BCS1L GRB2 SOS1 FGFR3 ERI1 FGF2 FRS2 UBE2J2 NELFB NELFA NELFCD NELFE PIK3R1 NAT8L MAPK1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260910%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TRAF6 MAP3K7 PDLIM7 MAPK8 CCL5 TRADD TNF HSP90AA1 IFNB1-4 CCL20 IKBKB CHUK IKBKG IRAK1 TRAF1 RELA MAP3K3 NFKBIA NFKB1 NFKB2 MAPK1 CXCL8 MAP3K14 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260910%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R7 PPP1CA PPP1R12A MAPK8 EIF2S1 PPP1CB PPP1CC PPP1R14A PPP1R15B PPP1R13B PPP1R11 PPP1R10 PPP1R8;STX12 PPP1R2-1 PPP1R9A DDIT3 PPP1R16B BCL2 PPP1R14B PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B PPP1R3E PPP1R1C PPP1R12C PPP1R1B PPP1R3D PPP1R12B PPP1R14D ATF6 ATF4 MAP1LC3A MBTPS1 ERN1 PPP1R15A XBP1 EIF2AK1 EIF2AK3 EIF2AK2 HSPA5 PPP1R3A MBTPS2 PPP1R14C FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes APOA4 SORT1 ACSL6 ACSL5 APOC2 SCARB1 PCSK9 LDLRAP1 MYLIP ACSL3 SLC27A1 APOE APOB LDLR ABCA1 FABP2 SOAT1 STAR FABP1 FABP3 FABP4 ACSL1 SLC27A4 LIPA STARD3 VDAC1 OSBPL5 NPC2 SOAT2 APOC1 SLC27A3 LRP1 SLC27A2 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260910%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection MYD88 TRAF6 IRF3 JAK1 STAT1 MAVS TYK2 TRAF3 TMPRSS2 IFNAR2 STAT2 OAS3 TLR9 TLR6 TLR2 TLR7 TLR4 TLR3 OAS1 TREML4 IRF9 ACE2 IFNAR1 IFIH1 EIF2AK2 TBK1 IRF7 IRAK4 IKBKE DDX58 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260910%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2A MEF2B;BORCS8-MEF2B KLF4 MEF2D CAMK2D NKX2-5 MEF2C CCND2 ELK1 SRF ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260910%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling PRKCA EIF4EBP1 MAPK3 LAMC2 LAMC1 PRKCD MAPK14 HRAS GAB1 PTPN11 RHOA IRS1 IRS2 ITGA6 GRB2 LAMA5 LAMA2 SOS1 LAMA1 SHC1-1 LAMA3 SRC LAMB3 LAMB2 LAMB1 AKT1 MTOR PIK3R2 PIK3R1 PTK2 MAPK1 ITGB4 RAC1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP357%HOMO SAPIENS Fatty acid biosynthesis PC HADH ACSL6 ACSL5 ACLY ECHS1 ACSL1 SCD ACAA2 ECH1 ECHDC1 ECHDC2 ECHDC3 DECR1 PECR ACSS2 ACACA ACSL3 MECR ACSL4 ACACB FASN 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5402%HOMO SAPIENS 10q22q23 copy number variation NRG3 ERBB4 IQUB SMC3 CEBPA MAT1A NME5 MAS1 TNFSF11 RSPH9 SMC1A RAD21 RSPH3 AFG3L2 STAG1 SH2D4B ADIRF VEGFA BUB1B LDB3 GHITM SF3B4 FAM25A;FAM25C;FAM25G;FAM25E-1 GRID1 MAD2L2 CDHR1 ADAM10 MMRN2 SH3GL3 DYDC2 RGR BMP2 PDS5B PDS5A SNCG C10orf99 RSPH4A SUSD2 WAPL TSPAN14 RSPH1 LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 GPR15 CCSER2 ZMYND11 GLUD1;GLUD2 ACTN2 BMPR1A ROPN1L OPN4 RSPH6A SIRT4 DNAJB13 PPARG NFKB1 DYDC1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260910%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides DES B4GALT1 SGMS1 B3GNT5 DGAT1 SPTLC1 ASAH1 SGMS2 CERS3 UGT8 CERS5 UGCG KDSR CERS6 CERS4 CERK CERS1 B4GALNT1 SPHK1 A4GALT CERS2 A3GALT2 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3R4 PIK3R3 PARP1 PIK3R6 ATM PIK3R5 SIRT1 IKBKG PARP3 PHLPP1 FOXO1-1 PARP2 RPTOR STK11 TSC2 MAPKAP1 MLST8 PDK1 PIK3CD AKT2 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A MTOR PIK3CG TSC1 PIK3C2B GSK3B PIK3R2 RICTOR PIK3R1 PIK3CA OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260910%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 ITGB3 TNFRSF11A SPP1 GPR68 MAPK8 PDGFB IFNB1-4 IFNAR1 TRPV5 SLC9A1 TNFSF11 ACP5 TNFRSF11B AIMP2 CTSK SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260910%WP1455%HOMO SAPIENS Serotonin transporter activity ITGB3 STX1A IL1B SLC6A4 MAOA NOS1 IL1R1 TPH2 SCAMP2 TGFB1I1 PPP2CB;PPP2CA NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2064%HOMO SAPIENS Neural crest differentiation DLL1 DLL3 DLL4 TFAP2A CTNNB1 MYC ASCL1 FGF2 MBP SOX9 PAX3 AXIN2 SOX5 HOXA1 CTBP2 OLIG1 OLIG2 SOX10 HDAC6 BMP4 TCF4 HDAC2 LHX1 HDAC11 MSX2 MIA HOXB1 PHOX2B GJB1 LHX2 LHX5 CDH1 DMBX1 ZIC1 FOXD3 OLIG3 FZD3 DCT WNT3A PRTG GBX2 GSK3B HDAC1 NFKB1 NFKB2 CDH7 HDAC3 TLX2 PAX7 RHOB HAND1 CDH6 CDH2 DLX5 SNAI1 SNAI2 NEUROG1 COL11A2 MITF DVL1 MSX1 DVL2 DVL3 GFAP FGF19 BMP7 HDAC4 HDAC5 RBPJ MYB AXIN1 HDAC8 HDAC9 HDAC7 FGF8 HES1 HES5 ISL1 TCF7L1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 WNT1 SMAD1 ID1 TBX6 ETS1 FGFR3 FGFR2 FGFR1 TFAP2E;TFAP2B COL2A1 HDAC10 HEY2 MPZ ITGB1 WNT8A PMP22 FERROPTOSIS%WIKIPATHWAYS_20260910%WP4313%HOMO SAPIENS Ferroptosis NCOA4 ACSL6 ACSL5 TXNRD1 CBS;CBSL SAT1 PCBP2 SLC7A11 STEAP3 CP SLC39A14 HMOX1 VDAC3 CTH TP53 TFRC SLC3A2 SLC40A1 COQ2 MAP1LC3B2;MAP1LC3B-1 SLC38A1 ACSL4 NOX4 ATG7 ATG5 NOX1 ALOX15 GCH1 SLC1A5 MAP1LC3C FTL-1 BACH1 SLC11A2 TF FDFT1 GPX4 GSS ACSL3 GCLC GCLM ACSL1 POR CISD1 SAT2 AIFM2 VDAC2-1 CHMP6 CHMP5 IREB2 DPP4 FTMT PCBP1 MAP1LC3A CYBB HMGCR PHKG2 PRNP HSPB1 LPCAT3 FTH1 SLC39A8 NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP268%HOMO SAPIENS Notch signaling DLL1 PSEN1 DLL3 DLL4 HDAC2 NOTCH2 NOTCH3 NOTCH1 CREBBP NCOR2 NOTCH4 KAT2A NUMB NUMBL JAG2 JAG1 PTCRA DTX3L DVL1 DVL2 DVL3 KAT2B MAML1 APH1A RBPJ NCSTN DTX1 APH1B RBPJL ADAM17 DTX2 RFNG HDAC1 DTX3 HES1 LFNG INPP5K HES5 KCNJ5 CTBP2 CTBP1 PSEN2 MFNG MAML3 DTX4 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260910%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC CCN1 PRKAA1 RHOB STK3 SAV1 YAP1-1 TEAD1 CCN2 TEAD3 MOB1A;MOB1B TEAD4 LATS2 RHOA LATS1 RHOC PRKAA2 TEAD2 PRKAG1 PRKAG2 PRKAG3 RHO PRKAB2 PRKAB1 HMGCR STK4 RHOD 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome OGDHL EIF4ENIF1 FAM170B VSTM4 MEN1 C10orf71 BAZ1B RGMB WDFY4 SMARCC2 PARG LRRC18 MYO1C ERCC8 ARHGAP22 ERCC6 ATF2 HSF1 ELK1 HSF4 DRGX DDX21 KDM4D C10orf53 SMARCA5 DEK SMARCB1 TMEM273 UVSSA CLOCK DLD GDF5 JUND DLST ITCH SLC18A3 NLRP3 ARNTL BMP2 NEO1 MAPK8 MYBBP1A SF3B1 SIRT1 SMAD1 CUL5 ELOA BCL2 SMAD9 CDH1 ERCC5;BIVM-ERCC5 SMAD5 BMPR1B BMPR1A NOG SIRT6 PCNA CHAT RIF1 FRMPD2 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260910%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA TALDO1 RPE;RPEL1 G6PD TKT PGLS PGD T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260910%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 JAK2 MAPK3 CD3G IL12B CD3E IKBKB PDPK1 TYK2 IKBKG CHUK CD247 CDKN1A FOS RHEB CD3D IRF2BPL PTPRC GRAP2 RELA GRB2 CCL28 IL18R1 SOS1 BCL2L1 NFKBIA CARD11 BCL10 MALT1 CCND1 IL2 IL4 IFNG LCP2 IL12A LAT PTEN TNF IFNB1-4 TP53 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 HLA-DRA RICTOR CCL19 CD28 IL17A MYD88 DEPTOR PRKCQ RASGRP1 PPP3CC PLCG1 BAX HRAS ICOS LTA IL23R JUN STAT4 RAF1 LCK IL12RB1 RPTOR IL12RB2 IFNAR2 NFATC1 IL23A TSC2 MLST8 FYN FOXO3 PIK3CD CD86 AKT1 MTOR CD80 TSC1 IFNAR1 CTLA4 GSK3B CDKN2A PIK3R1 ZAP70 ITPR1 MAP2K2;MAP2K1 NFKB1 MAPK1 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260910%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NLGN1 NLGN3 GRIN1 GRIA1 GRIA3 GRIA4 NLGN2 GRIA2 GRIN3B NLGN4X;NLGN4Y GRIN2A GRIN3A NRXN1;NRXN3;NRXN2 GRIN2C GRIN2B DLG4 GRIN2D PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260910%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3R3 PIK3CD PIK3R6 PIK3C2G PIK3R5 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R2 PIK3R1 PIK3CA TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260910%WP1471%HOMO SAPIENS Target of rapamycin signaling PRKCA EIF4EBP1 PRKAA1 IDI1 RHEB RPS6KB1 RRAGC PRKAA2 PRR5 PRKAG1 PRR5L PRKAG2 DDIT4L RRAGA PRKAG3 RRAGB RRAGD ULK3 CDC42 PRKAB2 RPTOR PRKAB1 TSC2 MAPKAP1 MLST8 ULK2 ULK1 AKT1 MTOR HMGCR TSC1 FKBP1A RICTOR AKT1S1 DDIT4 RAC1 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260910%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM TRAF6 UPF1 ACTL6A ATF2 HSF1 SMC3 MRE11 BRCA1 CASP9 CHEK2 CASP3 CHEK1 MCPH1 NBN APAF1 SMC1A CDC25C FANCD2 BRCA2 DCLRE1C TP53 MDM2-2 BLM ABL1 E2F1 BAK1 BID RAD52 RAD50 RAD51 CDK5 RNF8 PRKDC STK3 RAD17 YAP1-1 BAX PARP1 ATM ATR MDC1 RAD9A TP53BP1 LATS1 EXO1 TERF2 TRIM28 TP73 PCNA CDKN2A RASSF1 NABP2 RIF1 KAT5 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260910%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection MAP3K7 MAPK9 MAPK3 PDCD1 CSF2 IKBKB IKBKG CHUK ITK FOS CD3D RRAS CBL PTPRC GRAP2 GRB2 DAG1 SOS1 NFKBIA IL10 CARD11 BCL10 PTPN6 MALT1 CHP1 PAK1 AHSA1 IL2 IL4 IFNG CD40LG LCP2 LAT TNF IL5 CD4 MAP3K8 CD28 CALM1 MAP3K14 PRKCQ CDK4 PLCG1 ICOS NFATC2 MAP2K7 DLG1 JUN NCK1 RAF1 LCK CD8A PDK1 FYN AKT1 CTLA4 GSK3B PIK3CA ZAP70 MAP2K2;MAP2K1 NFKB1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260910%WP1772%HOMO SAPIENS Apoptosis modulation and signaling TRAF6 MAPK3 BAD CASP5;CASP4 IKBKB BCL2A1 FOS BBC3 CASP9 PIDD1 BCL2L1 AIFM1 NFKBIA CASP3 HRK APAF1 PEA15 BOK BIRC7 SEPTIN4-1 BIRC2 PTRH2 BIRC3 MADD ENDOG TNFRSF25 BLK DIABLO-1 BCL2L10 CFLAR BAG3 BMF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BNIP3 TP53 HTRA2 BCL2L2 CYCS-1 IL1R2 IRAK1 CASP7 CASP1 PMAIP1 CASP6 CASP2 BAK1 BID MCL1 TOLLIP MAP3K14 MYD88 PRKD1 PTPN13 MAPK8 CASP8 FAS BAX TRADD XIAP RIPK1 FADD CRADD TNFRSF1A JUN TRAF3 BCL2 DFFB DFFA CAPNS1 TNFRSF1B BIRC5 IL1R1 AIFM2 BCL2L11 MAP3K5 HSPA1A;HSPA1B FASLG DAXX NAIP BIK CDKN2A CASP10 TNFSF10 NFKB1 SMIM40 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260910%WP4255%HOMO SAPIENS Non small cell lung cancer MAPK3 RXRA PLCG2 BAD STAT3 PDPK1 RET JAK3 RB1 CDKN1A HGF GRB2 CASP9 SOS1 STAT5A STAT5B EGF CASP3 EML4 CCND1 TGFA ERBB2 RASSF5 DDB2 POLK TP53 FHIT CYCS-1 SOS2 EGFR E2F1 E2F2 E2F3 PRKCG BAK1 BID GADD45B GADD45A PRKCB GADD45G PRKCA CDK6 CDK4 NRAS PLCG1 CASP8 BAX HRAS KRAS ALK RXRB RAF1 MET RXRG ARAF CRABP2 CRABP1 KIF5C FOXO3 PIK3CD KIF5B AKT2 KIF5A AKT3 PIK3CB AKT1 RARB CDKN2A BRAF PIK3CA RASSF1 STK4 MAP2K2;MAP2K1 MAPK1 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260910%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb NDUFA9 MAPK3 POLR3E PRKAA1 NDUFA4 MAPK14 MAPK12 MAPK13 CDH18 MAPK11 UQCRB UQCR11 UQCR10 RPS6KB1 PRKAA2 UQCRQ PRKAG1 UQCRC1 PRKAG2 UQCRFS1 CYC1 PRKAG3 UQCRC2 PRKAB2 COX7C PRKAB1 COX5A RAB5IF TRPM7 PDZD9 SDR42E2 VWA3A CDR2 MOSMO-1 CALM1 CALM2 CDK2 CDK1 TRAP1 RPS6KA1 EEF2K EEF2 CALM3;CALM1 RPTOR NDUFS8 NDUFS3 MLST8 MTOR MAP2K2;MAP2K1 MAPK1 NDUFV1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260910%WP186%HOMO SAPIENS Homologous recombination RAD52 RAD50 NBN RAD51 RAD54B POLD3 POLD4 BRCA2 ATM POLD1 POLD2 MRE11 RPA1 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling TRAF6 IL1B CSF2 ICAM1 BCL2A1 IKBKB MMP1 CHUK TNFRSF1A IL6 MMP2 RELA PTGS2-2 MMP9 MMP3 CXCL8 CCND1 IL2 VCAM1 SELE IL1A BIRC5 BIRC2 BIRC3 CD40LG CFLAR TNF BCL2L2 REL RELB VEGFA CXCL2;CXCL3;CXCL1-1 NFKB1 NFKB2 EGLN2 SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260910%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL10 IL6R TRAF6 IRF3 JAK1 CSF2 STAT1 MAVS NUP98 EP300 TFAP2A IL6 TRAF2 CCL3L1;CCL3L3;CCL3;CCL18 IL10 CXCL8 RAE1 CCL4L2;CCL4L1;CCL4 TP53I3 PF4;PF4V1-1 LARP1-1 TLR7 TNF CXCL13 IFNB1-4 CXCL9 TANK CXCL17 IFIT2 AP1G1 IRF7 BSG CXCL2;CXCL3;CXCL1-1 LAG3 CD160 PPBP CXCL11 HDAC2 CASP8 HAVCR2 TRADD RIPK1 FADD TRAF5 CXCL12 TRAF3 IFITM3;IFITM2;IFITM1 SMAD2;SMAD3 IFNAR2 STAT2 CCL5 MX1-1 ACE2 CCL13;CCL2 IFNAR1 TBK1 CXCR2 DHX58 TGFB1 TRIM25 CXCL5;CXCL6 NFKB1 DDX58 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis SRD5A2 AKR1D1 HSD11B1 HSD11B2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP21A2 CYP11B1;CYP11B2 SRD5A1 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260910%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress MAP2K4 MAPK14 ATF2 ICAM1 IKBKB KEAP1 IKBKG CDKN1A FOS IL6 RHEB BCL2L1 CXCL8 CHEK1 NOS2 SOD2 IL1A HMOX1 CREB1 RPS6KA5 PTEN TNF CCNE1 TP53 NFE2L2 MDM2-2 CAT IPCEF1 PIP-1 NOX1 GSX1 CDK2 MAPK8 PINK1 ATR SIRT1 CUL3 PTGS2-2 MAP2K3 FOXO1-1 BCL2 NQO1 NRF1 AKT1 MAP3K5 MTOR TSC1 PIK3CA NFKB1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260910%WP5598%HOMO SAPIENS Sodium channel in epilepsy JAK2 PTPRN PSEN1 RACK1 SCNM1;TNFAIP8L2-SCNM1 SCN11A PDCD10 FGF13 SCN7A FGF12 SCN3B SCN3A SCN1B CAMK2A MAPK8IP2 BACE1 NFASC SCN4A SCN4B SCN2B RNF121 NEDD4 PRRT2 SCN9A SCN1A SCN10A SCN2A SCN8A FYN TNF WEE1 AKT1 GSK3B NEDD4L SCN5A FGF14 CALM1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation BMP4 BMP2 MAPK3 STAT1 MAPK14 MAPK12 MAPK13 NPR2 MAPK11 PTH1R CDKN1A SNAI1 THRA PPP2CB;PPP2CA RAF1 FGF18 FGFR3 CNP IHH SOX9 RBL1 FGF9 MAP2K2;MAP2K1 MAPK1 PTHLH ATG5 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260910%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD CD38 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260910%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP PORCN LRP6 LRP5 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260910%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 CDH1 MYC E2F1 IL6ST MMP9 BAX SOCS3 STAT3 CHI3L1 TP53 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC3 HDAC2 AHCY TYMS MTR-1 ATF2 SLC19A1 DHFR2;DHFR ADH1C;ADH1B;ADH1A ELP3 ALDH2 ALDH1A1 MAT1A ACSS2 MTHFR KAT2B HDAC4 HDAC5 ALDH1A3 HDAC8 HDAC9 HDAC10 HDAC7 HDAC1 ALDH1A2 CYP2E1 EHMT2 HAT1 HDAC6 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5366%HOMO SAPIENS NF1 copy number variation syndrome H4C6 ARF6 MAPK3 JARID2 NGFR MAP3K2 MAVS TUBB4A;TUBB;TUBB8B;TUBB8 RTN4R SOS1 EGF EIF3A ROCK2 CFL1 EXOC7 CCNE2 PRMT5 CCNE1 IFNB1-4 CCNA2-1 EGFR OMG MCL1 HOXA1 SUPT5H MYT1 DNMT1 RAD51 EXOC4 PER1 EXOC3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EXOC5 EXOC1 ATR NF1 RAD9A EXOC8 WDR48 RHOA NGF HOXA9 EXOC2 POLRMT EVL ATAD5-1 SDC2 RNF135 INPP5A MAP3K1 RFC5 RBBP7 RFC3 E2F6 RFC4 RAB11FIP4 BCL2 RFC2 TEFM SUZ12 RAF1 UTP6 COPRS EVI2A CRLF3 EVI2B METAP2 LIMK1 EED SYN1 EZH1 EXOC6 USP1 PCNA H4-16 ADAP2 RAB11A CRY1 MAPK1 H4C1 DDX58 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260910%WP1422%HOMO SAPIENS Sphingolipid pathway PPP1CA SGMS1 ASAH1 CERS3 CERS5 CERS6 CERK GAL3ST1 SPHK2 SPHK1 PPP2CB;PPP2CA ASAH2 SGPL1 SPTLC3 CERT1 SGPP2 ACER1 SERINC1 PLPP1 SPTLC1 GBA SGMS2 GBA2 UGT8 UGCG KDSR CERS4 CERS2 B4GALT6 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260910%WP3972%HOMO SAPIENS PDGFR beta pathway JAK2 PRKCA RASA1 MAPK3 JAK1 MAP2K4 MAPK8 PLCG1 STAT1 HRAS STAT3 ELK1 FOS GRB2 JUN MAP3K1 SOS1 STAT5A STAT5B SHC1-1 RAF1 PDGFRB STAT6 EIF2AK2 PIK3R1 PIK3CA MAP2K2;MAP2K1 PRKCB SRF STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260910%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 STAR CYP19A1 CYP17A1 HSD3B1;HSD3B2 CYP11A1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5406%HOMO SAPIENS 13q12 12 copy number variation DMD LINGO1 MAG MAPK9 FLNC RTN4 MAPK8 RHOA RTN4R SGCD TRAF5 SGCA MIPEP SGCB ADIPOQ TRAF1 DAG1 TRAF2 SGCG TRAF3 CDC42 SACS DTNA SSPN SNTB1 C1QTNF9B;C1QTNF9 ATXN1 SNTA1 TNFRSF19 SPATA13 RAC1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome MS4A1 ITGB2 CD63 IGSF8 PHF21A CD19 ALX4 TP53I11 PEX16 SYT13 HBEGF SDCBP REST B4GAT1 TSPAN18 IZUMO1-1 ITGA4 ITGA3 CLOCK ITGA6 LGALS3BP TIMP1 CHST6 EXT1 EXT2 SHH TP53 CD4 LEF1 HLA-DRA HLA-DMB ARNTL CHST1 B4GALT4 VANGL1 NRXN1;NRXN3;NRXN2 HLA-DMA CD151 NDST1 GLI3 CD82 SPPL2C ACCS C11orf96 C11orf94 LARGE2 ALKBH3 CD53 SLC35C1 MAPK8IP1 ITGB1 SLC25A17 B3GNT7 CRY2 PEX3 PRDM11-1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260910%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNB1 GNG2 CDK5 GNAI1 PPP1CA PRKACA-1 PPP1R1B DRD2 DRD3 DRD4 CHRNA3 KCNK9 CHRNA5 TH CHRNA4 CHRNA6 KCNK3 SLC18A2 CHRNB2 DDC ADCY2 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP69%HOMO SAPIENS T cell receptor signaling TRAF6 SKAP1 CBLB MAP3K7 MAPK9 MAPK3 PRKCD WAS MAPK14 ATF2 CD3G VAV3 CD3E IKBKB PDPK1 PTPN11 IKBKG CHUK VAV1 CD247 ITK GAB2 PSTPIP1 FOS DBNL CD3D FYB1 CBL GRAP2 RELA GRB2 SOS1 CRK NFKBIA SHC1-1 CARD11 BCL10 MALT1 CDC42 PAK1 CREB1 LCP2 LAT CD4 PTK2B MAP3K8 CD28 MAP3K14 PRKCQ MAPK8 PLCG1 HRAS ICOS NFATC2 MAP4K1 JUN NCK1 CRKL RAF1 LCK CD8A NFATC1 RIPK2 FYN AKT1 REL PIK3R2 PIK3R1 ZAP70 ITPR1 SH2B3 MAP2K2;MAP2K1 NFKB1 MAPK1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260910%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction TPO INHBB CCL27 CCL26 CNTFR IL27RA IL36A IL36B TNFSF14 XCL1;XCL2 GDF2 IL36G GDF1 GDF6 GDF7 EPO IL1F10 IL22RA1 CD27 IL20 TNFRSF13B PF4;PF4V1-1 IL26 IL27 CNTF TNFRSF13C CD40LG BMP15-1 IL17RB CCL14 CXCR6 RELT TNF CCL8 GDF10 CXCL13 CCL25 GDF11 CCL24 IL31 IL1RAP IL37 CD70 IL34 CXCR5 BMP8B ACKR4 CLCF1 NFIC LIF CCL19 AMHR2 CXCL2;CXCL3;CXCL1-1 MPL TNFRSF8 CCL21 IL13RA2 EDAR CXCL11 TNFRSF17 IL36RN TNFRSF14 BMP4 INHBC INHBE TNFRSF18 IL9R IL17RC IL1RL2 ACVR1C LTBR TNFRSF4 IL11RA TNFRSF1A CCL22 TNFRSF9 TNFSF9 TGFBR1-1 IL13RA1 TNFRSF1B ANP32B TSLP MSTN TNFRSF12A ACVR2A IL10RA IL6R NGFR TNFSF13B IL6 TNFSF11 LTB IL6ST IFNLR1 IFNL2;IFNL3;IFNL1 IL10 CCL11 CXCL8 IL18 CSF3R IL2 IL4 IL1A IFNG CSF1R IL7R GHR BMP5 BMP3 BMP6 NGF TNFSF4 ACVRL1 IL21 IL3RA IL22 CXCR4 IL23R CXCL12 TNFRSF21 CD40 IL18RAP IL25 IL21R IL12RB1 IL12RB2 IFNGR1 BMPR1B IL23A BMPR1A BMPR2 EPOR IL17RA FASLG IL1RL1 IFNK CCR9 IL20RA IL20RB IL19 GDF5 CCR8 EDA CCR6 EDA2R CX3CR1 CSF2RA CCL1 IL11 IL33 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CCL20 IFNB1-4 IL15 IL10RB IL3 IL7 ACVR1B GDF9 INHA FAS LTA LEPR CX3CL1 CCL23;CCL15 TNFRSF11B TNFRSF11A IFNAR2 IL1R1 IFNGR2 CCL5 ACVR1 IL31RA CCL13;CCL2 IFNAR1 PRL IL2RG IL17D TGFB2 GDF3 IL4R PRLR IL17C TGFB1 TGFB3 IL17B TGFBR2 CXCL10 IL2RA IL2RB CSF3 CSF2 LEP CCR3 CCR2 AMH IL13 CCL28 ACVR2B IL18R1 IL5RA CSF2RB CCL3L1;CCL3L3;CCL3;CCL18 CCL4L2;CCL4L1;CCL4 IL9 TNFRSF25 BMP7 GDF15 IL5 CXCL14 CXCL9 CSF1 IL1R2 CXCL17 IL17F PPBP IL17A TNFSF15 IL24 BMP10 CCR10 CCR1 NODAL XCR1 IL1RN ACKR3-2 CCR7 CCR5 CCR4 TNFRSF19 LIFR INHBA CXCR1 CXCR2 TNFSF10 CXCL5;CXCL6 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260910%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure STAR HSD3B1;HSD3B2 CYP11A1 BAX PRDX2 CASP3 MAPK10 PARP2 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TCF4 MEF2B;BORCS8-MEF2B CD79B CD79A LOC102723996;ICOSLG SPIB SLAMF1 POU2AF1 SPI1 STAT3 TLR10 EZH2 CDKN1A CDKN1B IL6 POU2F2 CCND3 LYN CCND2 SYK BCL2L1 CD40 IL21R MYC ID3 TLR1 TNFRSF13C TLR9 TLR5 TLR8 TLR6 TLR2 TLR7 TLR4 TLR3 BCL6 IRF4 IRF8 BCR E2F1 STAT6 CDKN2A IL4R MEF2C NFKB1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260910%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA1 CHAT PEMT CHKA ACHE PCYT1A GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260910%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis SLC2A1 GCG GLP1R PCSK1 INS;INS-IGF2 PCSK2 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260910%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling PRDX6 ACTG1 GJA1 MYO6 PRKAA2 EIF3H EIF3F CACNA2D1 EIF3D FN1 CCND1 SELE CNP CLTC RPS6KA5 AP2A1 MKNK1 EPRS1 BMP2 NAPA MAPK8 ARF4-1 WASF1-1 PLA2G4A ARPC5L AP2S1 RPL7 FADD LUC7L IER5 SND1 TPM3 EWSR1 BIN1 GPX1 RPL27 PRKD2 RPL26 FLII NCF2 ABCF2-H2BE1;ABCF2 GIGYF2 PRRC2C TRIP4 NR4A2 LARP7 NR4A1 RPL5-1 GIPC1 MMP10 FARSB KCNC3 EEA1 PBK MMP14 TBCA MOV10 RPLP2 CGNL1 NCL-1 SSR4 SSR3 TAL1 KANK1 SLC7A1 APOLD1 FGD5 BRD4 AKT1 CTNND1 SH3BGRL3 PLOD3 MTOR RPL10A TMSB10 SEMA6D ARMCX1 RAB37 FSCN1 GSK3B DSC1 HDAC1 LRRC59 PIK3R2 STIP1 PIK3R1 HLX TXNDC5 QKI PTMA RCAN1 PNP-1 MAP2K2;MAP2K1 TFCP2 SYNJ1 EPHA2 MAPK1 RCAN2 RAC1 TPP1 NRARP CAPZB RHOJ ADAMTS1 ARF6 ADAMTS9 MAPK3 DKK1 ACP1 PRKG1 MAP2K4 SARS1 CREBBP RPL13A-1 STAT1 SLC25A11 PBXIP1 MYO1C PRKCD DNAJB4 STAT3 SLC25A25 CDC42BPB GAB1 PTPN11 PTPN14 TPCN2 PTPN9 P4HB TRAF3IP2 RPL18A UBAP2L CHAC1 RPS6KB1 TMEM170A TNXB INPP4B GRB2 KATNAL2 ZNF555;ZNF57;ZNF556 PFN1 BCL2L1 ATP6V0D1 FXR2 SHC1-1 SHC2 ATP6V1E1 DHX36 MICAL2 CALU CXCL8 DHX29 NRP2 FAF1 CCDC124 HERPUD1 CLIC1 FJX1 NEXN HMGB1-1 CRIP2 GPC1 EPS15 PRKRA COPG1 FHOD1 TMOD1 TMOD3 PSMD11 HTRA1 SCUBE2 ZC3H15 DNAJA1-1 GRSF1 C15orf39 RND1 LRRFIP2 ARHGEF15 SHROOM2 PRKCI EPN1 RCN1 USP10 PRKCB FAM120A PRKCE PDE4DIP PRKCA FMNL3 ALDOA EZR PRKD1 NOTCH4 PRKCZ HSP90AA1 TEAD4 CCT7 JAG1 TAOK2 NFATC1 NOS3 FOXO3 HGS SET-1 PIK3CA FLT1 PGF TXN SPIRE1 DLL4 MAPK9 PLA2G5 MAPK14 MAPK12 CTNNB1 TRPC3 TRPC1 EGR1 FOXO4 EGR3 CREB1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MDM2-2 CYCS-1 ABL1 PPP1CA FAS FBXW11 FOXO1-1 ACACA FYN PRDX2 ACOT9 CCL13;CCL2 STAT6 OCLN-1 ARNT NFKB1 AFDN NR4A3 CCN1 PLAU CSRP1 CCN2 NUMB IDH2 ARRB2 TKT MMP2 TXNIP CAMKK2 NCF1 HDAC4 HDAC5 HDAC9 HDAC7 VEGFA MEF2C MYL2 ADAM10 BMP10 HRAS TFAM-1 PTGS2-2 ACKR3-2 NCK1 ETS1 ELOA MYH9 PTPRZ1 ENG NAP1L1 MAPKAPK5 LDHA GAPDH-1 PRKAA1 PGK1 CCRL2 ATF2 ELK1 CBL RELA PLAUR F3 ADAM9 SRPK1 NFKBIA PTPN6 PSMD4 KDR SRP54 LMAN1 ATF6 ATF4 EIF2AK3 RICTOR NOX4 TUBA1C FLNB SIAH2 PPM1G PPP3CA PLCB3 DUSP5 RBM39 MAP2K7 EIF4E MAP2K6 MAP2K3 JUN BCL2 RAF1 SMARCA2 EPHB2 MAP3K5 CYBB ERN1 CALR-1 FHL2 AMOT RACK1 CDH5 HBEGF TUBB4A;TUBB;TUBB8B;TUBB8 ANXA1 RHOC CFL1 MAPKAP1 SLC8A1 ITCH PTK2B IQGAP1 IGFBP3 ADRB2 KL NFATC2 STAM VPS39 BIRC5 PTPRJ CAPN2 RPS11 VCL PXN RAP1B RAP1A CAV1 PTK2 ITGB1 ITGB5 ITGB3 SDF2L1 SHB ITGAV SDCBP HYOU1 BMX PDPK1 ELOC-1 VAV2 RAPGEF1 ERG CRK ROCK1 ROCK2 SRC CDC42 PAK1 CSK PAK2 LDB2 BCAR1 YWHAE DECR1 SRF MMRN2 MAPKAPK2 MYH11 ACACB PPP2CB;PPP2CA CTNNA1 PABPC1;PABPC3 EIF4G2 DNAJB9 EIF2A RPS6 INPP5K PDIA6 OCRL CSRP2 PTPN1 ICAM1 RAB5A FGB FGA ASCC3 FGG GRB10 HBD;HBB DOK1 SOD2 TNFRSF25 ALB FUT1 GATA2 BSG EPB41 PLCG1 EIF4G1 RHOA GLUD1;GLUD2 S1PR1 P4HA2 LIMK1 MLST8 IGFBP7 FRS2 HSPA1A;HSPA1B HSPB1 NDRG1 DPM1 RAB4A AKT1S1 RAB11A PGD UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260910%WP5158%HOMO SAPIENS Urotensin II mediated signaling JAK2 IRF3 MAPK9 MAPK3 CREBBP COL1A1 MAPK14 ICAM1 STAT3 IKBKB UTS2R PTPN11 EP300 CTNNB1 CHUK IL6 MMP2 RELA CASP9 MMP9 CASP3 FN1 ABCA1 COL3A1 VCAM1 HMOX1 NCF1 NCF4 PTEN TNF CCNE1 CYBA HDAC5 ACTA2 EGFR ESPL1 GSK3A NOX4 TRPC4 HSPA2 IL1B CDK2 MAPK8 CDK1 CAMK2A ALOX5 BAX NPPA RHOA NCF2 DDIT3 BCL2 SMAD2;SMAD3 NPPB PRKACA-1 AIFM2 COL2A1 AKT1 CYBB AGTR1 PCNA GSK3B FSCN1 TGFB1 NFKB1 MAPK1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260910%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome APOC2 MECP2 TET1 REST CSRP1 SMC3 DLX5 SGK1-1 IGF1R FUS DHX9 OPRK1 SP1 CREB1 CNP YBX1 PTEN FGF2 CEBPD NCOR1 MBP FGF3 FGF4 FGF5 FKBP5 HNRNPH1 E2F1 CTCF MEF2C IGF1 GRID1 MYT1 MAG PSIP1 RBFOX1 GRIA1 GPRIN1 GRIA3 GAD1 SST TET3 GRIA4 ARHGEF26 DLX6 IGF2 TET2 CAMK2A NREP FUT8 MPP1 PRPF38A EZH2 POU4F1 UBE3A HNRNPF SP3 NF1 POU3F2 BDNF FOXG1 GRIN1 TAP1 TAF1 AKT1 MTOR BCL6 SIN3A HDAC1 GAMT RPS6 TARDBP GABRR2 CDON MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260910%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A USP1 ID1 ID2-1 ARCN1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260910%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia DKK1 WIF1 PPARD WNT1 CTNNB1 RUNX1T1 JUP ZBTB16 FZD6 CCND1 MYC FLT3 LRP6 SALL4 AKT1 AXIN2 LEF1 RARA GSK3B LRP5 CSNK1A1 PYGO1 PML BCL9 APC MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway IDI1 MVK IDI2 ACAT1 ACAT2 HMGCL MVD HMGCR HMGCS1-1 PMVK FDFT1 FDPS GGPS1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260910%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ3 FAAH CACNA1H PTGS1 PTGS2-2 TRPA1 TRPV1 KCNQ2 HTR1A SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260910%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis VAMP2 NAPA STXBP1 CACNA1B CACNA1A SNAP25 RAB3A CPLX1 RPH3A RIMS1 STXBP5 STXBP6 SYT1 NSF UNC13A SYP GDI1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260910%WP322%HOMO SAPIENS Osteoblast signaling ITGB3 FGF23 IBSP COL1A1 PDGFRA ITGAV PDGFB PDGFRB PTH1R SLC17A2 TNFSF11 PTH TNFRSF11B TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260910%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals PRKCA GSTA3;GSTA5;GSTA1;GSTA2 GCLM NQO1 HMOX1 MAPK8 MAF EPHB2 NFE2L2 KEAP1 SLC7A11 PIK3CA CEBPB GCLC AIMP2 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260910%WP5028%HOMO SAPIENS Glycine metabolism including IMDs ISCU SHMT1 AMT LIPT2 LIPT1 PNPO GLDC DLD GLRX5 GCSH-3 IBA57 HSCB LIAS NFU1 BOLA3 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260910%WP399%HOMO SAPIENS Wnt signaling and pluripotency MAPK9 WNT11 WNT7B MAPK10 EP300 PPARD CTNNB1 CCND3 CCND2 FOSL1 CCND1 MYC TP53 LRRK2 AXIN2 CTBP2 CTBP1 NKD1 NKD2 SOX2 JUN ESRRB MMP7 PPP2CB;PPP2CA FZD1 FOXD3 FZD3 PAFAH1B1 WNT3A WNT5A WNT7A WNT3 LRP6 CTNND1 GSK3B NFYA-1 PPP2R1B PPP2R1A NLK PPP2R2A;PPP2R2D MAP3K7 MAP2K4 CREBBP PRKCD PLAU TPTEP2-CSNK1E;CSNK1E TCF7 LDLR DVL1 DVL2 DVL3 FZD10 AXIN1 LEF1 PRKCG PRKCI TCF7L2 PRKCH TCF7L1 WNT5B PRKCB PRKCE APC PRKCA POU5F1;POU5F1B PRKCQ PRKD1 CD44 NANOG;NANOGP8 PRKCZ WNT6 WNT1 WNT2 RHOA RACGAP1 WNT4 WNT10B WNT10A FZD2 FZD5 FZD4 FZD7 FZD6 FZD9 FBXW2 FZD8 PPM1J PPP2R3B PTPA WNT2B PPP2R3A PPP2R2C PPP2R2B ZBTB33 PPP2R5E PPP2R5C WNT9B WNT16 LRP5 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation SMCR8 GAS8 RMND5A GPS1 MIEF2 LDHA RASD1 NT5M PRKAA1 FNIP1 CLUAP1 FNIP2 FBXL13 MYO16 MYO15A DRG2 CCDC65 GPR85 CLOCK RELA APP PRKAG2 ROCK1 MYC PRKAB1 TNFRSF13B ATG13 BIRC2 CREB1 ULK1 CLTC CLTA TNF TP53 BLM ARNTL TOLLIP PARD3 MAP3K14 MYD88 PARD6B IL1B NR1H3 PER1 RNF41 CDK1 BAX WWTR1 FOXA1 SREBF1 PEMT NR1H2 FLII JUN APBB1 FOXA2 RAI1 COPS6 MTOR PRDM1 NFKB1 CRY2 CRY1 ETV5 PPP1R12A ATG101 STAT3 C9orf72 PPP1R14A RAB8A RB1CC1 CARM1 RRAGA IFT172 USP8 IFT74 TRAF3IP1 PTEN TLR4 FHOD1 ARMC8 PRKN IFT88 COPS7A MED9 HES6 PRKCI CLEC16A GRIP1 SHMT1 YAP1-1 WDR26 RHOA CLTB MKLN1 GID4 MAEA TTC30A;TTC30B PCK1 TFE3 CFL2 IFT80 RPTOR FERD3L HSPB11 ALKBH5 MPRIP IFT20 LIMK1 DENR COPS4 MIGA2 COPS3 IFT22 MIGA1 COPS5 DRC3-1 IFT81 MLST8 TOM1L2 COPS2 IFT27 RANBP9 LLGL1 COPS8 IQCA1 BCL2L11 DRC7 TTC26 IFT46 RAB10 ATPAF2-2 PLD6 G6PC1 RAB39B BCL6 HBP1 DRC1 IFT52 GDI2 IFT57 IRF8 WDR41 FLCN EFCAB2 RMI2 ARG2 RMI1 TOP3A ITPK1 TFEB IQCD TCTE1 IQCG DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260910%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR MCM2 SMARCC2 UPF1 DCLRE1A UBE2D3-1 SEM1 UIMC1 TOPBP1 IKBKG HUS1 POLN RECQL EEF1E1 ABRAXAS1 MRE11 BRCC3 PPM1D BRCA1 RECQL5 RBBP8 CLSPN TDP1 RFWD3-2 CLK2 CHEK2 CHEK1 MCPH1 NBN SMC1A CDC25C CDC45 PLK1 SP1 FANCD2 BRCA2 TP53 MDM2-2 E2F1 BARD1 ATRIP MSH2 RPA2 XPA PML BRIP1 RAD52 RAD50 FANCI RAD51 CDK2 RNF8 FANCA PRKDC CDK1 RAD17 PALB2 PARP1 RAD1 ATM ATR MDC1 RAD9A FEN1 TP53BP1 POLB EXO1 SMARCAL1 TRIM28 WRN BCL6 USP1 PCNA XRCC5 RMI1 RPA1 TOP3A FOXM1 CEP164 MLH1 HERC2 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260910%WP3930%HOMO SAPIENS EDA signaling in hair follicle development EDA DKK1 DKK4 WNT3 SOSTDC1 SHH BMP1 LTB GLI1 RELB EDARADD PTCH1 EDAR SLEEP REGULATION%WIKIPATHWAYS_20260910%WP3591%HOMO SAPIENS Sleep regulation NLGN1 HTR2A AHCY PTGDR GHRH GHRL PTGDS HCRTR2 NPY2R HCRTR1 UTS2R ADORA1 FOS DLAT CHRNB2 IL6 CACNA1I SLC29A1 MTNR1B MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 IL18 STAR NPAS2 OXT-1 ADA DRD1 DRD2 DRD3 ADORA2A TH GRIN2A BTBD9 OXTR CST3 NPS CRH FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260910%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma PCGF1 H3-3A MACROH2A2 H2AZ2;H2AZ1 MACROH2A1 H2AJ MAPK3 EED H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EZH2 DUSP6 BCOR H2AB2;H2AB3;H2AB1 BCL6 KDM2B MAPK1 SUZ12 RNF2 VISUAL CYCLE%WIKIPATHWAYS_20260910%WP5534%HOMO SAPIENS Visual cycle LRAT ABCA4 RDH11 RHO RBP3 RDH8 RLBP1 RDH10 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RBP1 OPN1SW RDH5 RPE65 RDH12 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260910%WP334%HOMO SAPIENS GPCRs class B secretin like VIPR1 GHRHR ADCYAP1R1 CALCRL VIPR2 GIPR ADGRE5 GCGR GLP2R SCTR PTH2R CRHR1 CRHR2 ADGRE1 ADGRL2 PTH1R ADGRG2 ADGRL3 CALCR ADGRL1 ADGRL4 GLP1R DOPAMINE METABOLISM%WIKIPATHWAYS_20260910%WP2436%HOMO SAPIENS Dopamine metabolism MAOB TYR COMT PRKACA-1 DDC MAOA NQO1 SOD1 PPP2CB;PPP2CA PRKACB-1 TH BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 BMP2 SMAD5 DKK1 SST LEFTY2;LEFTY1 BCL2L11 CTNNB1 WNT4 DCN SMAD1 SFRP1 FOXO1-1 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260910%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CASP8 BAX MCU TNFRSF1A FFAR3;GPR42 TRPV5 TNFSF11 SMAD4 CASP9 CALCA TGFBR1-1 G3BP1 CASP3 SMAD2;SMAD3 RAF1 APAF1 NOS1 AKT1 MAP3K5 MTOR PPP3R1 PDE1B ACTA2 CRYZL2P-SEC16B;SEC16B RGN PTH BRAF BAK1 PIK3CA TGFB1 MAPK1 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260910%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 TST PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260910%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA SCP2 ACAA1-1 ACOX1 HSD17B4 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome RNF168-1 RNF8 CBX3-1 NIPBL ATM ATR MDC1 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260910%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development PRICKLE1 ANK3 SEMA3A SNAP25 SCN2A ATF6 ATF4 KCNQ2 DNM1L MAPT CSNK2A1;CSNK2A3 EIF2AK3 PRRT2 EIF2A CSNK2A2 SCN5A BRSK1 SPTBN4 CSNK2B BRSK2 DDIT3 ANK2 L1CAM SPTAN1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260910%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins RPL30 TXNRD2 SELENBP1 SEPHS1 PSTK EEFSEC POU2F1 SECISBP2 TRNAU1AP SARS1 SEPSECS TXNRD1 SARS2 SCLY GPX6 SP3 FOS GPX1 GPX4 RELA JUN TXNRD3 CREM SEPHS2 FABP1 SELENOO SELENON SELENOS SP1 SELENOT SELENOK SELENOI CTH SELENOP NFE2L2 DIO1 DIO3 NFKB1 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX15 ALOX5 EPHX2 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma IL6R MAPK3 JAK1 PODXL MAPK14 STAT3 PTPN11 MMP1 CDKN1A VAV2 IL6 BRCA1 RRM2-1 GRB2 CASP9 SOS1 BCL2L1 CASP3 CXCL8 CCND1 MYC NOS2 BIRC3 COL4A2 TP53 HNF1A LEF1 UCHL1 CASP7 E2F2 VEGFA MAPK8 HIF1A CD44 MYOF CTTN FRZB PTGS2-2 SMAD4 JUN TGFBR1-1 SMAD2;SMAD3 BIRC5 AKT1 FASLG CXCR1 TGFB1 NFKB1 RAC1 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ZP2 MAPK3 ANKRD39 LMAN2L CIAO2A DUSP2 NCAPH PARL RHOA CIAO1 FAM178B ITPRIPL1 TMEM127 COX11 CIAO2B CNNM3 CNNM4 FER1L5 STARD7 SEMA4C ASTL NEURL3 KANSL3 PLXNB2 MMS19 ERBB2 ADRA2B COL2A1 ANKRD23 MAPK1 SNRNP200 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260910%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ RAF1 CHUK TRAF6 IKBKG RRAS MAP2K6 MAP3K1 NFKBIA NFKB1 IKBKB MAPK1 MAP3K14 CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260910%WP2029%HOMO SAPIENS Cell differentiation index TLX3 TLX2 TLX1 LEFTY2;LEFTY1 STAT3 HDAC5 SRF MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260910%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 CCND1 CDH1 MYC TERT NRG3 ALPL ERBB4 TNF AKT1 ZEB2 CLDN4 SFRP1 ITGA6 TGFB1 ITGB1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260910%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways ALDH4A1 PEPD PRODH;LOC102724788 OAT PYCR1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260910%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer DNAJB1 GNAS-1 HDAC7 PRKACA-1 SIK3 SIK2 CRTC2 CREB1 HDAC4 HDAC5 SIK1;SIK1B AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260910%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction ADRB2 MYLK PPP1CB PPP1R14A RHOA GNAQ PLCB1 RYR1 CD38 IL13 ROCK1 CALM1 ROCK2 GDI1 ITPR3 MYL1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260910%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin CXCL10 IL2RB MAPK3 JAK1 MAP2K4 ITGA4 MAPK11 JAK3 IL6 CXCR4 NR3C1 CXCL12 CX3CL1 STAT5A STAT5B CCL3L1;CCL3L3;CCL3;CCL18 PIBF1 IL10 BCL2 CXCL8 CCL4L2;CCL4L1;CCL4 VCAM1 ESR2 IL4 PGR NCR1-1 IFNG MRC1 CCL5 MADCAM1 GAB3 CD69 TNF CCL8 IL15 GATA2 CCL13;CCL2 ANGPT2 IL3 ANGPT1 IL2RG CXCR3 VEGFA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E MCL1 CXCL11 SELL TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260910%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 SMARCD1 H3-3A SMARCD2 CDK6 SMO SMARCD3 CDK4 SMARCC1 SMARCC2 ACTL6A ARID1B EZH2 RB1 SMARCB1 SMARCE1 GLI1 PTCH1 SUZ12 EED GLI4 ARID1A DPF1 SMARCA4 GLI2 DPF2 ACTL6B DPF3 GLI3 CDKN2A RBBP4 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260910%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 KRAS GRB2 NRAS BRAF SOS1 HRAS PTPN11 NF1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260910%WP696%HOMO SAPIENS Benzo a pyrene metabolism CYP1B1 AKR1A1 CYP1A1 EPHX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260910%WP4628%HOMO SAPIENS Aerobic glycolysis augmented SLC2A1 GPT ALDOA LDHA GAPDH-1 PKM PGK1 ENO1 HK1 PFKM PGAM2 TPI1 GPI SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260910%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TRAF6 NLRX1 TERF2IP TOMM70 MAVS STING1 REN AGT RPS6KA1 IL6 BCS1L TRAF3 IL18 TERF2 ECSIT TNF PHB ACE2 ACE ACAD9 SIRT6 NDUFAF2 NLRP3 NDUFAF1 NFKB1 NOX1 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260910%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP19A1 HSD17B2 HSD17B3 COMT HSD17B10 CYP2C9;CYP2C19 HSD17B7 CYP1A2 HSD17B4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B1 CYP1B1 HSD17B8 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260910%WP5130%HOMO SAPIENS Th17 cell differentiation pathway JAK2 IL6R IL2RA JAK1 RXRA STAT1 MAPK14 CD3G STAT3 CD3E IKBKB TYK2 CD247 FOS IL6 CD3D CLOCK IL27RA STAT5A NFKBIA NR1D1 RUNX1 IL2 IL4 IL27 IFNG LAT GATA3 CD4 AHR ARNTL IL17F NFIL3 IL17A IL1B PRKCQ PPP3CA PER1 MAPK8 HIF1A PLCG1 HSP90AA1 IL21 IL22 IL23R RORC JUN RORA TGFBR1-1 HLA-DMA TBX21 SMAD2;SMAD3 IL21R LCK IFNGR1 NFATC1 FOXP3 IL23A MTOR IRF4 RARA STAT6 IL4R TGFB1 ZAP70 SOCS3 NFKB1 CRY1 MAPK1 GASTRIN SIGNALING%WIKIPATHWAYS_20260910%WP4659%HOMO SAPIENS Gastrin signaling MAPK9 LAMTOR3 MAPK14 ATF2 ELK1 IKBKB CTNNB1 CHUK CDKN1A CDKN1B FOS RELA CRK EGR1 NFKBIA CASP3 ROCK1 SRC CDC42 CCND1 PAK1 MYC BIRC2 BIRC3 CREB1 BCAR1 KIT TCF4 BMP2 MAPK8 YES1 ANXA2 IRS1 PRKD2 SLC9A1 FOXO1-1 JUN MMP7 SLC9A3 RAF1 CDH1 MAP3K11 MEF2D GAST FYN AKT1 MTOR ARHGEF28 CHGA GSK3B HDC RPS6 PIK3R2 PIK3R1 NFKB1 RHOD MAP2K2;MAP2K1 KAT5 MAPK1 RAC1 JAK2 EIF4EBP1 MEF2B;BORCS8-MEF2B MAPK3 KLF4 RHOB SERPINE1 BAD PRKCD STAT3 PTPN11 ARRB1 ARRB2 RPS6KB1 GRB2 SOS1 BCL2L1 SHC1-1 CXCL8 IL2 SP1 HDAC7 EGFR VEGFA MEF2C PRKCH PRKCE PRKCA PRKCQ PRKD1 PLCG1 SERPINB2 CD44 PIK3R3 ELAVL1 HRAS RHOA GNAQ TJP1 KRAS PTGS2-2 CLDN1 JAG1 PRKACA-1 BIRC5 FOXO3 PXN CCKBR CDKN2A PTK2 PIK3CA PPARG ITGB1 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260910%WP106%HOMO SAPIENS Alanine and aspartate metabolism GOT1-1 PC GPT ASL ASPA GAD1 DARS1 GOT2-1 GAD2 ABAT AGXT ASS1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260910%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis APAF1 BAD CASP8 MAPK14 BAX MAPK12 TNF MAPK13 BCL2L11 MAPK11 AKT1 FADD FASLG CASP7 BBC3 CASP9 BID MCL1 BCL2L1 CASP3 BCL2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP707%HOMO SAPIENS DNA damage response RB1 CDKN1A CDKN1B MRE11 HUS1B BRCA1 BBC3 CASP9 PIDD1 CCND3 CCND2 CHEK2 CASP3 SESN1 CHEK1 TLK2 CCND1 TLK1 MYC NBN APAF1 RFC1 SMC1A CDC25C CDC25A DDB2 CREB1 CCNE2 RRM2B FANCD2 CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 MDM2-2 CYCS-1 CCNB3 CCNB2 CCNB1 ABL1 E2F1 PMAIP1 SFN BID ATRIP GADD45B GADD45A RPA2 PML GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 PRKDC CDK1 RAD17 CASP8 FAS BAX RAD1 ATM ATR RAD9A AKT1 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260910%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia MCL1 ZAP70 BCL2 TP53 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260910%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260910%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 CCR5 FLT3 STAT3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260910%WP5606%HOMO SAPIENS Beta globin gene expression regulation DNMT1 HDAC2 TAL1 PPARGC1A CHD3 NR2C2 MYB KLF1 HBG2;HBG1 LDB1 HDAC1 BCL11A LMO2 MTA2 GATA1 NR2C1 HBD;HBB GATAD2B ZBTB7A ZFPM1 KDM1A AXON GUIDANCE%WIKIPATHWAYS_20260910%WP5289%HOMO SAPIENS Axon guidance NRP1 DPYSL5 SEMA6C ILK UNC5D ENAH SEMA7A NTN4 MYL12B NTN3 EFNB1 ROBO1 ABLIM3 PLXNA1 LRIG2 SRGAP2 LRRC4C PDPK1 NTNG2 RRAS SLIT1 SLIT3 TRPC1 ROCK1 FES SRC CDC42 GDF7 CFL1 BOC SHH ARHGEF12 DCC ABL1 RGMA EFNA1 PARD3 RYK-1 L1CAM PRKCA RASA1 CDK5 GNAI1 SEMA3A HRAS PRKCZ WNT4 CXCR4 CXCL12 EPHB1 NCK1 NGEF PTCH1 PARD6A DPYSL2 RAF1 MET FZD3 BMPR1B WNT5A FYN BMPR2 ROBO2 SLIT2 GSK3B ITGB1 RHOD SEMA5B EPHA2 MAPK1 ROBO3 RAC1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260910%WP2889%HOMO SAPIENS Oxytocin signaling PLCD1 GNAQ OXTR CD38 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260910%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid ALOX12B ALOX15 ALOXE3 GPX4 PTGS1 PTGS2-2 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EPHX3 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260910%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 ESD CES2 PON2 CES5A CES1 PON1 LIPA DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260910%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport SLC51A SLC51B AKR1D1 CYP7A1 ABCC3 ABCD3 ACOX2 ABCB4 ABCC4 SLC10A1 ABCC2 ATP8B1 CYP8B1 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC27A5 SCP2 FABP6 HSD17B4 HSD3B7 CYP7B1 CYP27A1 AMACR BAAT SLC10A2 SLC27A2 ABCB1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma EIF4EBP1 PRKAA1 PDPK1 NUMB CTNNB1 RB1 KEAP1 CDKN1A RHEB IGF1R TP63 CSMD3 RELA PRKAA2 SESN1 CCND1 TERT STK11 ERBB2 BIRC2 MAPKAP1 PTEN TP53 NFE2L2 SESN2 EGFR E2F1 RICTOR VEGFA RPS6KB2 CDK6 NOTCH2 CDK4 NOTCH1 LTBR NRAS CASP8 HRAS PIK3R5 FADD CUL3 EIF4E KRAS SMAD4 TRAF3 AJUBA RPTOR IRF6 FGFR3 TSC2 MLST8 FGFR1 AKT2 FAT1 AKT3 MAML1 PIK3CB AKT1 MTOR PIK3CG TSC1 REL CDKN2A FKBP1A RPS6 PIK3R2 PIK3CA PIK3R1 DDIT4 NFKB1 NFKB2 TGFBR2 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260910%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways GAPDH-1 REST PPARGC1A EP300 CPT1A CHRNA4 CTNNB1 GJA1 LOC110384692;C4A;C4B_2;C4B POU2F2 EGR1 CASP3 PRKACB-1 PRKAR2B PRKAR2A NKX3-1 VIPR1 ADCYAP1R1 SSTR2 PRKAR1B VIPR2 PRKAR1A SSTR1 SNAP25 CREB1 YBX1 ASCL1 TNF YWHAE HTR1A YWHAB YWHAQ YWHAH AVP MAOA NKX2-2 DDC CTCF SLC25A4 HTR2A VAMP2 PBX1 IL1B PLP1 TPH1 SLC1A3 POU3F2 CHRNB2 SOX2 BDNF NR3C1 JUN SLC9A3 TPH2 PHOX2B PPARGC1B TAC1 GRIN1 CREM SLC6A4 NEUROD1 CHRNA7;CHRFAM7A RUNX3 TH BHLHE40 YWHAG CHAT HDAC1 NFYA-1 PAH ECE1 YWHAZ NFKB1 NFKB2 IL6R TLX3 CREBBP AR MECP2 RET IL6 TACR1 PKNOX1 IL13 KCNH2 HADHB-1 CHRNB4 TSPYL1 GPD1L-1 ADCYAP1 DLX2 IL10 CEBPB DEAF1 SPTBN1 CXCL8 PHOX2A FEV CHRM2 CC2D1A CDCA7L EN1 ESR2 HTR3A IL1A NOS1AP ATP1A3 SP1 KCNJ8 MBD1 MAP2 GATA3 GATA2 MYB HDAC9 HSPD1 HSP90B1 HES1 VEGFA SCN5A MEF2C HES5 HADHA ACADM GABRA1 POU5F1;POU5F1B GNB3 ALDOA RYR2 SST SCN3B MAZ HIF1A NANOG;NANOGP8 SCN4B SP3 FMO3 IL1RN GCK TF NGF RORA KCNQ1 THRB TPPP PRKACA-1 LMX1B G6PC1 SNTA1 TP73 CAV3 NTRK2 FOXM1 AQP4 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260910%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 XPO1 XPO4 EIF5A;EIF5AL1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism TBXAS1 PTGS1 PTGS2-2 EPHX2 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260910%WP183%HOMO SAPIENS Proteasome degradation UBE2D3-1 NEDD4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 PSMC2-1 IFNG PSMD5 UCHL3 PSME3 UBE2B PSME1 PSME2 PSMD11 PSMD10 UBA7 RPN2 RPN1 PSMB10 PSMB9 UCHL1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2D1 UBB;UBC UBA1 H2AC4 H2AZ2;H2AZ1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBE2D3;UBE2D2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMA2-1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMB8 PSMD12 PSMD13 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260910%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation GSTO1 ATP1A1 COA3 SOD1 AS3MT CAT SDHA UQCRFS1 VDAC1 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260910%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP2 LIPC MOGAT3 AGPAT2 DGAT2 DGAT1 AGPAT4 PLPP1 GK GNPAT GPD1 AGPS PNPLA2 MOGAT2 MOGAT1 AGPAT1 AGPAT3 GK2 LIPF GPAM LPL AGPAT5-1 LIPE PLPP3 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260910%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome ARHGAP44 SHARPIN MAP3K7 LZTS3 GRIA1 BAIAP2 ABI1 CAMK2A GRM5 GRIA2 GRM1 HRAS CTTN SYNGAP1 DLGAP1 DBNL DLG4 ARHGEF7 HCN1 HOMER1 CDC42 PAK1 GRIN1 SHANK3 ACTB-1 RAP1A ADGRL1 CTNND2 GRIN2B ITGB1 ITPR1 TAB2 SPTAN1 SERINE METABOLISM%WIKIPATHWAYS_20260910%WP4688%HOMO SAPIENS Serine metabolism SHMT1 SRR PSAT1 PHGDH SHMT2 TYMS PSPH DHFR2;DHFR MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260910%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TRAF6 IRF3 NLRX1 TOMM70 MAVS STING1 REN TICAM1 CGAS BCS1L TRAF3 CTSV;CTSL TMPRSS2 NDUFB9 ECSIT TLR7 TLR3 PHB PHB2 ACE2 ACE ACAD9 AGTR1 AGTR2 IFIH1 TBK1 IRF7 NDUFAF1 IKBKE NFKB1 NFKB2 DDX58 NOX1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260910%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity CS ALDH2 ACO2 ALDH3A2 ACSS2 ALDH9A1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP2571%HOMO SAPIENS Polycystic kidney disease pathway WNT11 MAPK3 PRKAA1 SLC12A2 GNA11 PLCG2 WNT7B IKBKB CTNNB1 FOS RHEB IGF1R PRKAA2 PRKAG1 SFRP4 PRKAG2 EGF VEGFB PRKAG3 SRC DVL1 ADCY6 DVL2 CCND1 MYC PRKAB2 DVL3 STK11 PRKAB1 ERBB2 KCNN4 SSTR2 KDR GNAI3 GNAI2 TNF FZD10 IGF1 WNT5B GNAI1 PKD2 CFTR PDE1A NRAS HRAS WNT6 WNT1 GNAS-1 WNT2 RPS6KA1 WNT4 GNAQ WNT10B WNT10A KRAS FZD2 JUN FZD5 FZD4 FZD7 FZD6 FZD9 FZD8 FZD1 FZD3 WNT3A WNT5A TSC2 WNT7A WNT2B WNT3 PKD1 MTOR TSC1 GSK3B WNT9B WNT9A WNT16 BRAF FLT1 MAP2K2;MAP2K1 WNT8A WNT8B LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP4478%HOMO SAPIENS LTF danger signal response pathway MYD88 TRAF6 TREM1 IL1B AGER IL1A LTF TLR2 CD14 TLR4 TNF IFNB1-4 IL6 IRAK1 IRAK4 NFKB1 MAPK1 CXCL8 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma SLC2A1 CUL2 CREBBP HIF1A CADM2 COL21A1 ELOC-1 EP300 ELOB CDKN1A VHL FH TFE3 DVL2 PRCC TGFA BIRC7 DIAPH1 PDGFB RBX1 TGFB2 VEGFA SFPQ-1 TGFB1 TGFB3 ARNT TFEB EGLN1 SETD2 EGLN3 EPAS1 CTSK EGLN2 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP561%HOMO SAPIENS Heme biosynthesis UROS PPOX CPOX HMBS ALAD ALAS2 ALAS1 FECH UROD MAPK CASCADE%WIKIPATHWAYS_20260910%WP422%HOMO SAPIENS MAPK cascade MAPK3 LAMTOR3 MAP2K4 NRAS MAP3K2 MAPK14 HRAS MAPK12 ELK1 PLCB3 MAPK10 MAP3K12 RASA3 SIPA1 MAP2K7 RRAS KRAS MAP2K6 GRB2 MAP2K3 JUN MAP3K1 SOS1 RAF1 ARAF MAP2 MBP SOS2 BRAF MAP3K3 MAP2K2;MAP2K1 MAPK1 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260910%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX HPGD ALOX15 EHHADH-1 ALOX12 LTC4S CYSLTR1 DPEP1 PTGR1-1 ALOX5 LTA4H CYSLTR2 ACAA1-1 PTGR2 ACOX1 ACOX3 ALOX15B PPARD CYP4F3;CYP4F2;CYP4F12;CYP4F11 ACOX2 GGT5 TRPA1 LTB4R2 TRPV1 FPR2 LTB4R PPARA G PROTEIN SIGNALING%WIKIPATHWAYS_20260910%WP35%HOMO SAPIENS G protein signaling AKAP8 GNG10 ADCY8 GNG13 GNA11 PRKCD GNGT1 RRAS ADCY4 ADCY2 PRKACB-1 ADCY7 ADCY6 PRKAR2B PRKAR2A PDE4B ADCY5 PDE4A PDE4D-1 PRKAR1B PRKAR1A GNAI3 GNAI2 ADCY9 GNB5 GNA13 GNA12 GNAO1 ARHGEF1 PDE1B ADCY1 PRKCG PRKCI PRKCH CALM1 PRKCB GNB2 PRKCE PRKCA GNB1 ADCY3 GNB3 PRKCQ PPP3CA PRKD1 GNAI1 PPP3CC PDE1A NRAS HRAS PRKCZ PLCB3 AKAP9-1 PDE7A RHOA GNAS-1 GNAQ AKAP12 AKAP10 AKAP11 KRAS PDE8B SLC9A1 PDE8A PDE4C AKAP5 PDE1C AKAP7 AKAP6 AKAP4 AKAP3 GNAZ AKAP1 GNA14 AKAP13 GNA15 GNG5 KCNJ3 GNAL GNG4 PDE7B PRKACA-1 GNG8 PRKD3 ITPR1 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260910%WP585%HOMO SAPIENS Interferon type I signaling RACK1 EIF4EBP1 JAK1 STAT1 MAPK14 STAT3 PTPN11 TYK2 VAV1 GAB2 PDCD4 RAPGEF1 RPS6KB1 CBL PTPRC CRK STAT5A PTPN6 CREB1 MAPKAP1 RPS6KA5 PRMT1 EIF4A1 IRS1 EIF4E IRS2 MAP2K6 MAP2K3 MAP3K1 CRKL STAT4 LCK RPTOR IFNAR2 EIF4B STAT2 MLST8 FYN PIK3CD PIAS1 IRF9 MTOR RPS6KA4 IFNAR1 RAP1A SOCS1 REL PIAS3 RPS6 PIK3R2 PIK3R1 ZAP70 SOCS3 RAC1 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260910%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders DPYS PUS1 CKB UPB1 TYMP TYMS NT5C NT5C3A RRM2B TK2 RRM1 UMPS DHODH DPYD RRM2-1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260910%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CXCL10 TMPRSS2 IL2RA IL2 IL1B CSF3 TNF AGT CCL13;CCL2 ACE2 IL7 IL6 CCL3L1;CCL3L3;CCL3;CCL18 IL10 CXCL8 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling SLC2A1 LDHA PKM SERPINE1 PGK1 HIF1A HK1 BAX SLC16A1 BCL2A1 EDN1 PTGS2-2 BCL2L1 EPO TGFA PFKL NOS2 PDHA1 BIRC5 HIF1AN BNIP3L BNIP3 IGFBP2 TP53 IGFBP1 ANGPT2 ANGPT1 IGFBP3 PMAIP1 VEGFA BAK1 BID MCL1 TGFB3 ARNT EGLN1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260910%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO4A1 SLCO1A2 SLCO3A1 SLC7A5 SLCO1C1 SLC7A8 SLC16A2 SLC16A10 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260910%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 WT1 PTGDS DMRT1 DHH GATA4 MAPK11 FOXL2 CTNNB1 NR5A1 SRY WNT4 AMH INSL3 FGFR2 RSPO1 FST EMX2 SRD5A1 SOX8 SOX9 RBFOX2 CBX2 FGF9 AMHR2 MAPK SIGNALING%WIKIPATHWAYS_20260910%WP382%HOMO SAPIENS MAPK signaling HSPA6 RASGRF2 DUSP16 PPM1A PPM1B PTPN7 ATF2 ELK1 IKBKB FGF21 CHUK FOS RELA FLNA CACNA2D1 EGF CACNA2D3 CACNA2D2 PRKACB-1 CACNA2D4 CACNB1 MYC CACNB2 HSPA8 CACNB3 CACNB4 CACNG6 CACNG7 PDGFB CACNG8 RPS6KA5 PDGFRB CACNG1 FGF2 CACNG2 TNF CACNG3 ATF4 CACNG4 CACNG5 PPP3R1 LRRK2 MKNK1 MKNK2 MAP3K8 TAB2 TAB1 MAP3K14 RASA1 IL1B FLNB PPP3CA FLNC PPP3CB CACNA1B PPP3CC CACNA1A MAPK8 DUSP4 PLA2G4A DUSP2 RPS6KA3 MAPT TNFRSF1A MAP2K7 MAP3K4 MAP2K6 MAP2K3 JUN MAP3K1 TGFBR1-1 DDIT3 NR4A1 RAF1 MAP3K11 AKT2 AKT3 AKT1 MAP3K5 RPS6KA4 MAP3K6 NLK MAP2K2;MAP2K1 CACNA1D MAP3K13 MAPK1 RAC1 CACNA1C MAP3K7 CACNA1F MAPK3 MAP2K4 MAP3K2 PRKCD CACNA1S DUSP6 DUSP1 MAP3K12 IKBKG RRAS GRB2 TRAF2 SOS1 RASA2 FGF20 FGF23 FGF22 IL1A FGF17 FGF16 FGF19 PLA2G4F PLA2G4D PLA2G4E FGF1 GNA12 FGF3 FGF4 SOS2 FGF5 EGFR FGF6 FGF7 FGF8 FGF9 PRKCG FGF14 PRKCA HSPA2 RASGRP1 FGF13 FGF12 FGF11 STK3 CD14 MAP4K3 MAP4K4 MAP4K1 MAP4K2 CACNA1H NGF TAOK2 ARAF FGF18 FGFR4 NFATC1 FGFR3 FGFR2 DUSP10 FGF10 FGFR1 RRAS2 MRAS RAP1B RAP1A MAP2K5 FASLG NTRK2 BRAF MAPK9 MAPK7 LAMTOR3 JMJD7-PLA2G4B;PLA2G4B RAC3 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 NTF4 CDC25B CRK CACNA1I JUND CASP3 MAX CDC42 PAK1 PAK2 RASGRP2 RASGRP4 RASGRP3 TP53 RELB GADD45A SRF RASGRF1 ELK4 MAPKAPK2 FAS BDNF IL1R1 TGFB2 TGFB1 TGFB3 STK4 NFKB1 NFKB2 TGFBR2 TRAF6 NTRK1 ARRB1 ARRB2 PDGFA IL1R2 MEF2C NFATC3 NRAS MAPK8IP2 HRAS NF1 DUSP3 KRAS CRKL PTPN5 STMN1 PRKACA-1 NTF3 ECSIT TAOK1 DAXX HSPA1A;HSPA1B HSPB1 MAPK8IP3 PPP5C PTPRR DUSP8 DUSP9 DUSP7 MAPKAPK3 RAPGEF2 MAPKAPK5 MAPK8IP1 HSPA1L TAOK3 CACNA1E CACNA1G SMIM40 MAP3K20 MELANOMA%WIKIPATHWAYS_20260910%WP4685%HOMO SAPIENS Melanoma MAPK3 STK19 GRM3 RHOB PREX2 PDE5A BAD ERBB4 PTPN11 RB1 CDKN1A RHOC GRB2 CALML6 CALML3 SOS1 CALML4 MITF SHC2 CCND1 PAK1 KDR DDB2 EXOC7 PTEN POLK TP53 MDM2-2 GRIN2A SOS2 E2F1 E2F2 KIT E2F3 BAK1 GADD45B GADD45A CALM1 CALM2 GADD45G CDK6 CDK4 NRAS PIK3R3 BAX HRAS CTTN NF1 RHOA KRAS RAF1 CDH1 CALM3;CALM1 ARAF PIK3CD AKT2 AKT3 VCL PIK3CB AKT1 CDKN2A PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 RAC1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP7A1 RXRA FGF19 SLCO2B1 IP6K3 PPARGC1A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC10A1 ABCB4 CYP8B1 FKBP5 NR1H4 IRS2 BAAT ABCB11 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2A1-4 NR0B2 SLC27A5 THERMOGENESIS%WIKIPATHWAYS_20260910%WP4321%HOMO SAPIENS Thermogenesis SMARCD1 KDM3B NPR1 SMARCD2 SMARCD3 UCP1 ADCY8 PRKAA1 SMARCC1 SMARCC2 PRDM16 ACTL6A MAPK14 ATF2 BMP8A;BMP8B PPARGC1A ARID1B MAPK12 SLC25A29 MAPK13 FGF21 CPT1A MAPK11 ACTG1 RHEB PNPLA2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PRKACB-1 LIPE PRKAB2 PRKAB1 CREB1 ARID1A ACTB-1 ADCY1 BMP8B KDM3A RPS6KA3 RPS6KA2 RPS6KA1 MAP2K3 ACSL3 CPT1B CPT2 CREB3L2 CPT1C SMARCA2 TSC2 DPF1 SMARCA4 DPF3 MAP3K5 MTOR RPS6 ACSL6 ACSL5 PRKG1 SMARCB1 SMARCE1 RPS6KB1 CREB3L3 GRB2 CREB3L4 CREB3L1 SOS1 ADCY4 ADCY2 ADCY7 ADCY6 GCG ADCY5 ADCY10 ADCY9 SOS2 ACSL4 SLC25A20 RPS6KB2 ADCY3 NRAS HRAS GNAS-1 KRAS CREB5 CNR1 KLB KDM1A RPTOR PRKACA-1 RPS6KA6 ACSL1 FGFR1 MLST8 PRKG2 ACTL6B TSC1 FRS2 SIRT6 CREB3 ADRB3 PPARG AKT1S1 ZNF516 PLIN1 MGLL 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome ASF1A FOXC2 FOXC1 GP1BA TSKS PITX2 EMC10 ZDHHC8 ZNF274;ZNF74 RCC1 GSC2 TANGO2 C22orf39 CLDN5 CLDN3 THAP7 TSSK2 RTL10 NPRL2 NPRL3 TRMT2A ESS2 CBX5 KLHL22 PI4KA SLC25A1 CDC42 GP5 GP9 LZTR1 LRRC74B AIFM3 MRPL40 PAK4 TNPO1 PLK1 SCARF2 SNAP29 DGCR2 SEPTIN11-1 GP1BB RANGAP1 SLC7A4 GNB1L TP53 SHH DEPDC5 SERPIND1 CCDC188 NCOR1 ARVCF PAX3 LOC102724770;DGCR6;DGCR6L RANBP1 SEPTIN8 ACTA2 RBX1 ALDH1A2 ARNTL SEPTIN5 SRF MAG POLR2A CLTCL1 PPP1CB SREBF1 BCL2 RAF1 FOXA2 MED15 ALDH4A1 COMT PRODH;LOC102724788 SREBF2 KPNB1 GBX2 DRD2 DROSHA DGCR8 HDAC3 RTN4 CDH15 CYP26A1 RTN4R RAN RELN CYP26B1 MALT1 UFD1 TBX1 CDC45 XPO1 PRKN EGFR FGF8 HES1 TXNRD2 NKX2-5 ACTC1;ACTG2 HAND2 CHRD HIRA VWF HIRIP3 CUL3 GLUD1;GLUD2 RORC CLDN1 CRKL SLC2A4 FGFR2 FGF10 FGFR1 P2RX6 OAT SHOC2 H4C1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260910%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP2A13;CYP2A6;CYP2A7-1 AKR7A2 GSTM1;GSTM2-1 AKR7A3 CYP1A2 EPHX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260910%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL13A-1 RPS29 RPS20 RPS21 RPS24 RPS23 RPL18A UBA52 RPS6KB1 RPS15A RPS3 RPS2 FAU RPL4 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPL30 RPL7A RPS27A RPS6KB2 RPL37A-1 RPL35 RPL36-1 RPL39 RPL15-1 RPL21 RPL23 RPL22 RPS3A RPL24 RPL29 RPL28 RPL10;RPL10L-1 MRPL19 RPL14 RPL7 RPS6KA3 RPL13 RPS6KA2 RPL12-1 RPS6KA1 RPL18 RPL17 RPL19 RPL35A RPL27 RPL23A RPL3L RPL26 RPS25 RPS27 RPL27A RPL5-1 RPS15 RPS14 RPL11 RPS17 RPS16 RPLP2 RPS6KA6 RPS19 RPS18 RPL38 RPS11 RPS10 RPS13 RPS12 RPL10A RPS9 RPS7 RPS8 RPS5 RPSA RPS6 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260910%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade LCK CD8A CD8B;CD8B2 PDCD1 NFATC1 IFNG STAT3 CD3G PDCD1LG2 PTPN11 CD3E CD274 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 NFATC2 CD3D JUN NFATC3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NFAT5 ZAP70 NFATC4 BATF NFKB1 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260910%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ITGB3 MYLK PRKCQ MAPK3 CREB1 ITGAV PLCG1 VCL PXN TJP1 MFAP5 JUN PTK2 ACTN1 ITPR1 LPP MYL2 MAPK1 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260910%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways MAPK9 PRKAA1 CKB REST PPARGC1A ELK1 IKBKB MAPK10 RHEB PRKAA2 AHI1 PRKAG1 PRKAG2 EGF PRKAG3 CASP3 PRKAB2 PRKAB1 CREB1 RAB3A RPS6KA5 MBP RICTOR BID IL1B HDAC2 MAPK8 CASP8 BAX HMGCS1-1 MAP2K7 EIF4E BDNF NR1H2 BCL2 ABCG4 ABCG1 MAP3K10 SLC12A5 RAF1 HMGCS2 RAB3GAP1 CYP46A1 NEUROD1 SREBF2 TSC2 HAP1 AKT2 KIF5A AKT3 AKT1 MTOR SIN3A HDAC1 PIK3R2 PIK3R1 ITPR1 NFKB1 MAP2K2;MAP2K1 MAPK1 EIF4EBP1 MAPK3 MAP2K4 SLC12A2 BAD DHCR7 IL6 RPS6KB1 PRR5L BCL2L1 APOE OPA1 ABCA1 SP1 PTEN BNIP3 HTT EGFR GABRB3 CASP7 GABRB2 GABRB1 GABRG3;GABRG2 GABRE GABRD GABRQ GABRA2 GABRA1 GABRP DEPTOR GABRA6 GABRA5 GABRA4 GABRA3 GABRG1 PIK3R4 CYP51A1 PIK3R3 GRM1 HRAS PIK3R6 PIK3R5 RPTOR MLST8 BCL2L11 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG HMGCR TSC1 PIK3C2B NTRK2 PIK3CA AKT1S1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260910%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination FGFR2 MAPK11 FOXL2 CTNNB1 AXIN1 RHOA SRY SOX9 WNT4 GSK3B MAP3K4 FGF9 MAP3K1 ROCK1 MAPK1 GADD45G SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260910%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling HTR4 HTR6 ELK4 ATF1 MAPKAPK2 MAPK3 CREB1 HTR7 RPS6KA5 ELK1 GNAS-1 RAP1A BRAF NR3C1 EGR1 MAP2K2;MAP2K1 MAPK1 SRF TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260910%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc DLST PC OGDH ACO1 PDHA1 ACLY SUCLG2 IDH3A CS MDH1 DLAT IDH1 DLD SDHA FH PCK1 FOCAL ADHESION%WIKIPATHWAYS_20260910%WP306%HOMO SAPIENS Focal adhesion ELK1 ACTG1 FLNA ACTN1 EGF FN1 ACTN4 TNC CCND1 ERBB2 KDR PDGFB PDGFRB ACTB-1 IGF1 FLNB FLNC MAPK8 JUN BCL2 RAF1 MYL5 MYL7 TLN2 TXK TNK2 MYL12A TNK1 MYL10 SRMS PTK6 PARVB MYLPF AKT2 PARVG AKT3 ARHGAP5 AKT1 MYLK4 FGR STYK1 GSK3B PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 RAC1 PDGFD MAPK3 PDGFC PPP1R12A COL1A1 COL1A2 BAD VAV1 HCK IGF1R TNXB GRB2 SOS1 RELN VEGFB SHC4 SHC1-1 SHC2 VEGFD IBSP TNN TNR PDGFRA COL4A2 COL4A1 PTEN COL4A4 COL4A6 EGFR VTN CHAD PRKCG COL5A3 PRKCB COL5A2 PRKCA LAMC3 LAMC2 PIK3R3 LAMC1 XIAP VWF COL6A2 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 MYLK2 THBS4 BUB1B-PAK6;PAK6 THBS3 ITGA2B CAPN2 LAMB3 LAMB2 LAMB1 TLN1 PIK3CD VCL SHC3 PIK3CB PXN RAP1B RAP1A VASP CAV3 CAV2 CAV1 BRAF PTK2 PIK3CA ITGA10 FLT1 ITGA11 ITGB1 PGF ITGB5 ITGB4 ITGB3 ILK MAPK9 RAC3 ITGB8 ITGAV ITGB7 ITGB6 VAV3 ITGA4 PDPK1 MAPK10 ITGA3 CTNNB1 ITGA2 ITGA1 VAV2 ITGA8 RAPGEF1 ITGA7 ITGA6 ITGA5 CCND3 CRK CCND2 DOCK1 ITGA9 ROCK1 ROCK2 SRC CDC42 PAK1 PAK3 PAK2 PAK4 BIRC2 BIRC3 COMP PPP1R12B ZYX BCAR1 EMP2 ARHGAP35 RASGRF1 PPP1CA PPP1CB PPP1CC FYN MYL12B PIP5K1C HGF PDGFA MYLK SPP1 PPP1R12C BLK VEGFA MYLK3 MYL2 HRAS RHOA TESK2 CRKL MET DIAPH1 PARVA COL2A1 THBS1 VEGFC FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260910%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 VLDLR LIPC SCARB1 PLTP APOA1 CETP LRP1 APOA2 APOE LPL LDLR LCAT CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260910%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling JUNB MAPK9 MAPK3 CYP11A1 GNA11 PLCG2 PRKCD MAPK14 ELK1 TFAP2A CTNNB1 ARRB1 JUP POMC ARRB2 FOS GJA1 RELA CASP9 PRKAA2 JUND NFKBIA CASP3 CXCL8 IL18 FOSL1 STAR IL2 GRK3 SP1 CREB1 GNAI2 TLR4 NCOA2 CRHR1 KRT16;KRT14 CRHR2 GNB5 GNAO1 RAPGEF3 CYP21A2 PRKCI PRKCB GNB2 PRKCA GNB1 TCF4 GNB3 PRKCQ GNAI1 MAPK8 CAMK2A PLCG1 PARP1 HSP90AA1 RHOA GNAS-1 CACNA1H GNAQ ACACA NR4A2 CYP11B1;CYP11B2 BCL2 NR4A1 GNAZ RAF1 TRIM28 HSD3B1;HSD3B2 NOS3 AKT1 MAP3K5 RAP1B CRHBP KRT1 ERN1 IVL GRK6 GSK3B TBX19 FOSL2 BRAF FOSB ECE1 SULT2A1-4 PTK2 TGFB1 MAP2K2;MAP2K1 NFKB1 MAPK1 CRH UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260910%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GFPT1 GCK HK2 UGDH GALE UXS1 PGM1 HK1 HK3 GPI PGM3 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP5304%HOMO SAPIENS Cholesterol metabolism APOA4 LIPC APOC2 SCARB1 ANGPTL8 APOH ANGPTL3 PLTP EBP NSDHL SC5D DHCR24 DHCR7 LBR APOA1 ABCB11 APOE LDLR ABCA1 STAR LIPA STARD3 VDAC1 OSBPL5 APOC1 SORT1 CYP7A1 CD36 IDI1 CYP51A1 MVK MSMO1 HSD17B7 ACAT2 TM7SF2 HMGCS1-1 PMVK PCSK9 LIPG FDFT1 LDLRAP1 MYLIP MTTP FDPS LSS SAR1B TSPO NPC1L1 MGAT1 APOB ABCG8 ABCG5 FABP2 SQLE SOAT1 APOC3 SLC27A4 DGAT1 NPC2 MVD HMGCR CYP27A1 CETP NPC1-1 LRP1 LRPAP1 APOA2 CIDEB LPL VAPA LCAT PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260910%WP3527%HOMO SAPIENS Pre implantation embryo CELF3 NR3C2 FOXQ1 MACROH2A2 KHSRP ZAR1 KLF4 AQP9 DPPA3 PADI6 BARX2 CDX2 LEUTX ZFP36 NLRP5 MTA3 DPRX-1 MOS TPRX1;RAX2 ZSCAN4 TBX3 NKX2-1 EGR1 DLX2 IRX5 FOXD1 GATA3 SOX8 GATA2 MYBL1 ATP1A1 E2F5 TCF7L1 ZFP42 POU5F1;POU5F1B PBX1 DNMT3L NANOG;NANOGP8 ELAVL1 TEAD4 SOX11 HNRNPAB SOX2 ESRRA MXD1 DDIT3 CDH1 SMARCA4 TFAP2E;TFAP2B IRF4 BATF3 ZFP36L2 SIX3 FOSB NANOGNB AQP3 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260910%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence GOT1-1 SLC2A1 SLC2A4 IL1B PRKAA1 PARP1 ELAVL1 SIRT5 TP53 SIRT1 NMNAT2 MDH2 SIRT2 SIRT3 G6PD MDH1 IL6 CCL27 NAMPT GOT2-1 RELA HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260910%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 BMP4 RUNX2 SMO FOXI3 GTPBP4 CTNNB1 GJB6 SNAI1 TP63 GLI1 LAMA5 CCND2 PTCH1 PDGFA CCND1 CDH1 MYC EDA FZD1 WNT5A FGFR2 PDGFRA GLI2 SHH FGF1 LEF1 INHBA NCAM1 ITGB1 LRP5 NFKB1 EDAR INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260910%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 MTOR INSR RPS6KB1 IRS1 TBC1D4 RPS6 AKT2 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260910%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity ITGB3 ITGB2 CFP ITGAX ITGAV PROS1 CLU MPP5 C8G C3AR1 LOC110384692;C4A;C4B_2;C4B C5AR2 CR2 CASP9 MASP2 MASP1 CASP3 CFB CFD C1QB C1S APAF1 C1R CFI C5AR1 C2 CX3CR1 C6 C7 C9 CD55 C8B C8A CR1L;CR1 MBP CYCS-1 CFH-3 BID PARD3 PARD6B CASP8 FAS BAX MBL2-1 CX3CL1 MFGE8 ATP8B2 TGFB2 TGFB1 TGFB3 C3-1 C1QC CAP1 PATJ C4BPA C4BPB ATP8B1 FCN2;FCN1 ATP10A ATP11C SCRIB ATP11A TYRO3 LLGL2 MARK3 ATP8B3 DLGAP5 C5 PLSCR1 PLSCR3 PLSCR4 GAS6 CRB2 COLEC12 CRB1 COLEC10 PARD6G SUSD4 IFNG CD59 CSMD1 DEDD DIABLO-1 MERTK HTRA2 VTN CASP7 BAK1 PRKCI PRKCZ XIAP SERPING1 PARD6A AXL MARK2 MARK1 FASLG COLEC11 CASP10 ITGAM MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260910%WP391%HOMO SAPIENS Mitochondrial gene expression PPP3CA SP1 CREB1 NRF1 GABPB1 MTERF3 TFB2M CAMK4 PPARGC1A MTERF1-1 TFB1M PPRC1 TFAM-1 HCFC1 MYEF2 GABPA POLRMT ESRRA PPARGC1B ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260910%WP2374%HOMO SAPIENS Oncostatin M signaling JAK2 JUNB MAPK9 MAPK3 JAK1 STAT1 PRKCD MAPK14 STAT3 PTPN11 TYK2 JAK3 CDKN1B FOS OSMR RELA GRB2 IL6ST SOS1 STAT5B EGR1 JUND NFKBIA SHC1-1 CASP3 CEBPB OSM SRC CREB1 PTK2B CASP7 RICTOR VEGFA PRKCH PRKCB PRKCE PRKCA CDK2 MAPK8 HIF1A HRAS IRS1 KRAS RAF1 AKT1 PXN MTOR LIFR PIAS3 RPS6 PIK3R1 SOCS3 MAP2K2;MAP2K1 NFKB1 MAPK1 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260910%WP5241%HOMO SAPIENS Mitochondrial beta oxidation EHHADH-1 ECHS1 DECR1 ACAA2 ECI1 ACSL3 HSD17B10 ACADSB ACADL HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260910%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling JAK2 IL6R MAPK3 NGFR NTRK1 STAT3 ELK1 IKBKB PPARD CTNNB1 IKBKG CHUK RUNX1T1 CDKN1A JUP FOS ZBTB16 IL6 RHEB IGF1R RELA GRB2 SOS1 NFKBIA SHC1-1 SRC CCND1 MYC INSR KDR PDGFRA FLT4 ULK2 PDGFRB PTEN SALL4 TP53 MDM2-2 CSF1R AXIN2 SOS2 LEF1 EGFR KIT CSNK1A1 PML BCL9 APC DEPTOR TELO2 HRAS WNT1 KRAS TTI1 FOXO1-1 JUN FZD6 RAF1 MET NFKBIE RPTOR FGFR4 FGFR3 FGFR2 TSC2 FLT3 MLST8 FGFR1 LRP6 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR PIK3CG TSC1 RETN TEK KSR1 RARA GAREM2 REL GSK3B NTRK2 BRAF PIK3CA PTK2 FLT1 AKT1S1 PYGO1 LRP5 MAP2K2;MAP2K1 NFKB1 EPHA2 MAPK1 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260910%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ HBG2;HBG1 LDB1 HBA2;HBA1 TAL1 LMO2 GATA1 HBD;HBB GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260910%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TCTN2 TCTN1 BBS9 BBS7 CEP97 CLUAP1 CC2D2A BBS5 ARMC9 RPGRIP1L TMEM216 CEP104 ARL3 ARL13B MIB1 TMEM67 INPP5E PIBF1 BBS2 BBS1 MKS1 CPLANE1 TMEM231 TTC8 TMEM17 KIF3A B9D1 EVC2 TTC21B EVC KIAA0753 OFD1-1 CEP20 BBS4 IFT172 IFT74 CEP192 TRAF3IP1 IFT88 CEP19 TXNDC15 CDK20 TRAPPC11 KIFAP3 WDPCP TEDC1 TEDC2 ARL6 FBF1 TTBK2 KIF3B CEP76 CPLANE2 SASS6 CEP83 CIBAR1 TTC23 C2CD3 CBY1 EFCAB7 TMEM107 MKKS CEP295 BBS10 BBS12 CILK1 TUBD1 TULP3 KATNB1 RAB23 SCLT1 TUBE1 RABL2A;RABL2B CEP162 CEP44 DYNC2H1 DYNC2I2 CEP43 LZTFL1 DYNC2I1 TTC30A;TTC30B DYNLT1 IFT140 DYNLT2B WDR19 IFT122 IFT80 FUZ WDR35 HSPB11 DYNC2LI1 IFT20 IFT43 IFT81 IFT27 TTC26 IFT46 IFT52 IFT57 CEP120 TCTN3 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260910%WP5174%HOMO SAPIENS Ulcerative colitis signaling NFATC1 IL4 FOXP3 IFNG MAF TLR2 TNF IL5 GATA3 IL2RG STAT6 IL13 IL4R TGFB1 NOD2 HLA-DMA IL10 NFKB1 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260910%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer POLE2 RPA3 RRM1 MAPK13 RB1 CDKN1A SMC3 POLA1 CDKN1B MCM7 RRM2-1 SKP2 CCND3 CDC25B TFDP1 TFDP2 MCM3 MCM4 CHEK1 MCM6 CCND1 FAF1 MYC PRIM1 HMGB2 SMC1A CDC45 CDC25A ORC1 HMGB1-1 TOP2A CDC7 CCNE2 CCNE1 WEE1 TP53 MDM2-2 CCNA2-1 PRMT2 CCNB2 CCNB1 ANLN ABL1 E2F1 E2F2 BARD1 CDT1 MSH6 TTK E2F3 RPA2 CDK6 H2AZ2;H2AZ1 DNMT1 CDK4 CDK2 PRKDC CDK1 TYMS FANCG DHFR2;DHFR SMC2 KIF4B;KIF4A DCK NPAT HLTF POLE PLK4 RABIF RFC5 RBBP7 ZNF655 RFC3 CCDC6 RFC4 RAF1 STMN1 SMARCA2 SUV39H1 POLD3 SAP30 RBP1 PCNA SIN3A HDAC1 RPA1 RBBP4 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260910%WP4271%HOMO SAPIENS Vitamin B12 disorders CBLIF CD320 MMAB MTRR TCN2 TCN1 MTR-1 CUBN MMUT AMN MMAA MMACHC MMADHC 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome POLR1A POLR1B ARF6 POLR1D CSF2 POLR1E PLCG2 STAT1 IL6 LGALS3 GRB2 IL36A IL36B IL36G ANAPC1 GAS6 IL1F10 IL2 IL1A MERTK CXCL13 GATA3 CSF1 IL1RAP IL37 IL36RN IL1B IL1RL2 POLR1C IL1RN ZC3H8 ZC3H6 CHCHD5 ACOXL POLR2L PSD4 ARL14 CKAP2L IL1R1 IL23A POLR1F POLR1G POLR1H FBLN7 TMEM87B SLC20A1 BCL2L11 TULP1 TTL SOCS1 POLR2E POLR2F POLR2H PTK2 SOCS3 MAPK1 RAC1 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260910%WP3286%HOMO SAPIENS Copper homeostasis MT3 SLC31A1 MTF1 MT2A BACE1 CCS XIAP MTF2 MAPT SLC11A2 COX11 STEAP3 APP FOXO1-1 JUN ADAM9 CASP3 CCND1 STEAP4 SOD3 SOD1 SP1 PTEN FOXO3 AKT1 TP53 MDM2-2 COX17 ATP7B ATP7A PRNP SLC31A2 COMMD1 ADAM17 ATOX1 GSK3B SCO1 STEAP1 STEAP2 PIK3CA ADAM10 APC OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis FADS2 ACSL1 SCD FADS1 ELOVL2 ELOVL5 ACOT2;ACOT1 ELOVL1 ELOVL3 SCD5 ACSL3 ELOVL6 ACSL4 FASN SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome RAD50 NBN SMC3 MRE11 SMC1A PAXIP1 RAD21 BRCA1 RAD18 ATM MDC1 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260910%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 MTOR INSR RPS6KB1 IRS1 TBC1D4 RPS6 AKT2 IL9 SIGNALING%WIKIPATHWAYS_20260910%WP22%HOMO SAPIENS IL9 signaling IL9 IL9R MAPK3 JAK1 STAT1 STAT3 JAK3 IL2RG GRB2 PIK3R2 PIK3R1 STAT5A STAT5B CDK9 MAP2K2;MAP2K1 MAPK1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260910%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX18 HIGD1A PET117 COX14 COX10 CMC1 TMEM177 PNKD NDUFA4 SMIM20 COX20 COX6A1 COX11 COX6B1 COX7A2 COX7B COX4I1 COX7C COX8A COX5B COX5A COX6C COX17 COA3 SURF1 COX19 COX15 TACO1 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260910%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway MSN RHOA RACGAP1 EZR ANLN SEPTIN2 RAB35 RDX AFAP1 MYL2 KIF23 OCRL TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP75%HOMO SAPIENS Toll like receptor signaling CXCL10 TRAF6 MAP3K7 IRF3 MAPK9 MAPK3 NFKBIB MAP2K4 STAT1 MAPK14 MAPK12 IL12B MAPK13 IKBKB MAPK10 MAPK11 IKBKG CHUK LBP FOS IL6 RELA CCL3L1;CCL3L3;CCL3;CCL18 NFKBIA CXCL8 CCL4L2;CCL4L1;CCL4 TICAM2 SPP1 TIRAP TLR1 TLR9 TLR8 TLR6 IL12A TLR7 TLR4 TNF TLR3 IFNB1-4 CXCL9 IRAK1 MAP3K8 IRF7 TOLLIP TAB3 CXCL11 TAB2 TAB1 MYD88 IL1B MAPK8 CASP8 LY96 CD14 RIPK1 FADD TICAM1 MAP2K7 MAP2K6 MAP2K3 JUN TRAF3 CD40 IFNAR2 TLR5 TLR2 CCL5 AKT2 AKT3 CD86 AKT1 CD80 IFNAR1 IRF5 TBK1 IRAK4 IKBKE MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy JAK2 JUNB MAPK3 COL1A1 NTRK1 STAT3 CCN2 GANC DDR2 CNMD P4HTM FOS LAMTOR1 RELA ACAN JUND CEBPB VHL FOSL1 COL3A1 FGF23 IBSP SPP1 KDR SOX9 RELB VEGFA PRKCA RUNX2 COL10A1 HIF1A NGF JUN FGFR4 MMP13 FGFR3 FGFR2 FGFR1 AKT2 COL2A1 AKT3 AKT1 FOSL2 FOSB PIK3CA ARNT NFKB1 MAPK1 EPAS1 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA1 HEXB B3GALT4 ST3GAL4 ST8SIA5 ST3GAL1 ST3GAL2 HEXA NEU3 ST8SIA6 NEU4 ST3GAL5 B4GALNT1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260910%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK9 MAPK3 PRKAA1 MAPK8 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 G6PC2 G6PC3 PRKAA2 ACACA PRKAG1 PRKAG2 ACACB PRKAG3 PRKAB2 PRKAB1 ACLY PCK2 G6PC1 CRP SLC27A2 MAPK1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260910%WP2324%HOMO SAPIENS AGE RAGE pathway JAK2 MAPK9 AGER MAPK3 ALPL STAT1 PRKCD MAPK14 ATF2 STAT3 INHBB IKBKB CHUK LGALS3 MMP2 DDOST RELA CASP9 MSR1 MMP9 STAT5A STAT5B NFKBIA SHC1-1 CASP3 ROCK1 FOXO4 SRC CDC42 MSN NOS2 INSR TIRAP SOD1 SP1 NCF1 CYCS-1 EGFR PRKCB PRKCA MYD88 EZR MAPK8 HIF1A CASP8 PRKCZ PLA2G4A RHOA IRS1 FOXO1-1 JUN INS;INS-IGF2 MMP7 RAF1 SMAD2;SMAD3 MMP14 MMP13 DIAPH1 NOS3 AKT1 IRAK4 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260910%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD AHRR CDK2 NRAS NCOR2 CD36 HRAS FGF21 HSP90AA1 CYP1A2 RET EP300 NF1 RB1 CDKN1A CDKN1B CYP1A1 KRAS RELA PTGS2-2 PLAGL1 HPGDS AIP KLF6 PSRC1 NCOA7 ESR1 GCLC SRC RAF1 MYC NRIP1 NQO1 CCL1 TNF CDC37 NFE2L2 CYP1B1 AHR EGFR E2F1 VEGFA ARNT MAP2K2;MAP2K1 NFKB1 LPL MAPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260910%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TCF4 CDH1 SIX1 HDAC2 SUV39H1 ELF3 FOXC2 ZEB1 EZH2 SIRT1 ZEB2 GSC2 SNAI1 SNAI2 GRHL2 PRRX1 HDAC1 TGFB1 KDM1A KLF8 SUZ12 ELF5 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260910%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling JAK2 MAPK3 JAK1 MYL12B APEX1 STAT1 MAPK14 STAT3 PDPK1 RB1 TSHR CDKN1B IGF1R RPS6KB1 SCRIB CCND3 PLD1 ADCY2 CGA SRC KCNIP3 PDE4D-1 CREB1 GNAI3 RALGDS GNAI2 CCNE1 GNA13 GNA12 GNAO1 GNB1 ADCY3 GNAI1 CDK4 CDK2 HRAS RAP1GAP GNAS-1 RPS6KA1 GNAQ PLCB1 MAP2K6 MAP2K3 RAF1 GNG2 RBL2 TSHB AKT1 MTOR RAP1B RAP1A RPS6 PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 ERYTHROPOIESIS%WIKIPATHWAYS_20260910%WP5607%HOMO SAPIENS Erythropoiesis EPO KITLG CD79A HBA2;HBA1 FAS EPOR GDF11 GATA2 HBZ TFRC IL3 FASLG TF HBG2;HBG1 PTPRC IL3RA CD34 KIT GATA1 HBD;HBB PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260910%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases KHK H3-3A SNAP23 PAK2 PKM PGK1 PRPS1 PDK1 STAT3 BUB3 AKT1S1 BECN1 MYL2 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260910%WP5461%HOMO SAPIENS Primary ovarian insufficiency COX10 PPM1B ATG9A PCCA PCCB POLG RFWD3-2 ESR1 PRORP RCBTB1 NBN STAR MEIOSIN POF1B MEIOB SIL1 SOHLH2;CCDC169-SOHLH2 HFM1 NANOS3 BMP15-1 LARS2 SGO2 PREPL NOBOX KHDRBS1 AARS2 SOX8 AIRE SYCP2L MST1R HMMR WDR62 LIG4 BLM SYCE1 ANTXR1-1 SOHLH1 ZP3;POMZP3 KASH5 AMHR2 SWI5 HELQ ERAL1 HARS2 FIGLA DAZL CPEB1 GDF9 DIAPH2 STAG3 FSHR MSH5 H1-8 HROB DMC1 LHX8 FANCI BNC1 RAD51 FANCM MCMDC2 XRCC4 ELAVL2 FANCL C1orf146 LMNA FANCA MRPS22 TWNK WT1 FANCC SPIDR C14orf39 HAX1 LGR4 GALT ATM SLX4 SHOC1 CCDC185 MGME1 MND1 CENPE XPNPEP2 SPATA33 EXO1 EIF2B2 WRN NUP107 PRDM1 MLH1 EIF4ENIF1 CYP19A1 POLR2C ZAR1 AR POLR3H ERCC6 PSMC3IP FOXL2 NR5A1 AMH TP63 DCAF17 NUP43 ESR2 MSH4 STRA8 CLPP SALL4 BRCA2 XRCC2 HSD17B4 HSD17B1 ATG7 ALOX12 NOTCH2 CYP17A1 FMR1 LAMC1 GNAS-1 BMP6 EIF2B1 EIF2B5 EIF2B4 BMPR1B BMPR1A PMM2 BMPR2 TGFBR3 MCM8 MCM9 CAV1 PGRMC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260910%WP51%HOMO SAPIENS Regulation of actin cytoskeleton RAC3 MAPK6 GIT1 MAPK4 WAS RDX FGF21 ITGA1 ACTG1 ARHGEF7 CRK ACTN1 DOCK1 EGF FN1 ROCK1 ROCK2 CDC42 PAK1 CSK PAK3 PAK2 PAK4 PDGFB PDGFRB FGF2 BCAR1 ACTB-1 ARHGAP35 CHRM1 PIP4K2A WASF1-1 NCKAP1 MYH10 SLC9A1 RASSF7 ARPC5 SSH2 SSH3 SSH1 VIL1 DIAPH3 PIP5KL1 ARHGEF4 RAF1 ARHGEF6 FGD1 WASF2 ABI2 PIK3R2 PIP4K2B PIK3R1 PIP4K2C MAP2K2;MAP2K1 MAPK1 RAC1 ENAH MAPK3 PPP1R12A PIP5K1A PIP5K1B PIP5K1C MOS VAV1 RRAS F2 PFN1 SOS1 CHRM4 CHRM5 PDGFA MSN FGF20 CHRM2 MYLK FGF23 FGF22 CFL1 FGF17 FGF16 PDGFRA FGF19 F2R APC2 GNA13 FGF1 GNA12 FGF3 ARHGEF1 FGF4 SOS2 FGF5 IQGAP1 FGF6 EGFR FGF7 FGF8 FGF9 FGF14 CYFIP2 MYL1 APC MYL3 EZR FGF13 BAIAP2 FGF12 FGF11 NRAS PIK3R4 PIK3R3 CD14 PIK3R5 GSN RHOA KRAS BDKRB2 BUB1B-PAK6;PAK6 CFL2 FGF18 PAK5 FGFR4 FGFR3 LIMK1 FGFR2 DIAPH1 FGF10 FGFR1 PIK3CD RRAS2 VCL PIK3C2G BDKRB1 MRAS PIK3CB PXN PIK3C2A CHRM3 PIK3CG PIK3C2B BRAF PTK2 PIK3CA PIK3C3 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response RAD52 CCND1 CDK6 MYC CDC25A CREB1 CCNE1 ATM TP53 CDKN1A CDKN1B ABL1 E2F1 CCND3 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP4149%HOMO SAPIENS White fat cell differentiation IRF3 NR1H3 KLF4 SREBF1 WNT10B CEBPA NR2F2 NR3C1 FOXO1-1 TLE3 RORA INS;INS-IGF2 STAT5A STAT5B DDIT3 CEBPB MECOM CTNNA1 EBF1 CREB1 EGR2 CEBPD GATA3 GATA2 KLF15 KLF2 KLF5 IRF4 ZNF423 RARA PPARG TCF7L1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260910%WP1971%HOMO SAPIENS Integrated cancer pathway RAD50 JAK1 POU2F1 CDK4 CDK2 CDK1 STAT1 CASP8 BAD BAX ATM BACH1 ATR MMP1 RB1 CDKN1A CDKN1B MRE11 BRCA1 BBC3 CASP9 CDC25B CHEK2 CASP3 BCL2 CHEK1 SMAD2;SMAD3 MYC ATF1 CDC25A PLK1 PTEN CDKN2B AKT1 TP53 MDM2-2 MAP3K5 BLM E2F1 BARD1 NOXA1 MSH6 MSH2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260910%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells NRAS HRAS CTNNB1 HGF KRAS SMAD4 TGFBR1-1 SMAD2;SMAD3 RAF1 MET TGFA ERBB2 PROM1 WNT3A WNT5A DKK4 AKT1 TGFBR3 MTOR AXIN1 MFGE8 EGFR TGFB2 TGFB1 TSPAN8 TGFB3 TGFBR2 APC PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases CPS1 GLS2 DPYS CAD UPB1 OTC TYMP ABAT TYMS NT5C AGXT2 NT5C3A RRM2B TK2 RRM1 UMPS DHODH ALDH6A1 DPYD RRM2-1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260910%WP2878%HOMO SAPIENS PPAR alpha pathway ACADM APOA5 CCND1 APOC3 MYC EHHADH-1 NR1H3 FABP1 CYP7A1 CDK4 KLK15 RXRA CDK1 PLTP SCP2 ACAA1-1 CPT1A CYP8B1 PPARA APOA1 SLC27A1 APOA2 CPT2 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260910%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG GNAQ PCSK1 SLC2A2 SLC5A1-1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260910%WP2338%HOMO SAPIENS miRNA biogenesis DICER1 TARBP2 RAN XPO5 DROSHA DGCR8 BLADDER CANCER%WIKIPATHWAYS_20260910%WP2828%HOMO SAPIENS Bladder cancer CDK4 NRAS HBEGF HRAS MMP1 RB1 CDKN1A MMP2 KRAS MMP9 DAPK2 EGF DAPK3 CXCL8 SRC RAF1 CCND1 CDH1 ARAF MYC ERBB2 FGFR3 TYMP UPK3A RPS6KA5 TP53 MDM2-2 THBS1 DAPK1-1 EGFR E2F1 CDKN2A PIK3R2 BRAF VEGFA PIK3R1 RASSF1 MAP2K2;MAP2K1 MAPK1 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260910%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway CXCL10 POLR3B RNF125 IRF3 POLR3D POLR3E NFKBIB POLR1D NLRX1 CYLD MAVS POLR3H TREX1 STING1 POLR3K IKBKB ISG15 IKBKG CHUK CGAS IL6 RELA NFKBIA IL18 CCL4L2;CCL4L1;CCL4 IL33 IFNB1-4 PYCARD CASP1 IRF7 ATG12-1 ATG5 IL1B CASP8 RIPK3 TRADD RIPK1 FADD POLR1C POLR2L ZBP1 CCL5 POLR3GL POLR3A ADAR POLR3C POLR3F POLR3G AIM2 POLR2E POLR2F TBK1 CASP10 POLR2H TRIM25 IKBKE NFKB1 DDX58 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260910%WP5526%HOMO SAPIENS Age related macular degeneration PRKAB2 RPTOR PRKAB1 MAPK3 PRKAA1 MLST8 PPARGC1A SIRT1 MTOR MDH1 RPS6KB1 PMAIP1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PARP2 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260910%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGFR PTGER3 HPGD PTGS1 TBXA2R CYP11A1 PTGDR PTGIR PTGDS CBR1-1 PPARGC1A PTGIS PLA2G4A EDN1 ANXA2 ABCC4 ANXA1 TBXAS1 PTGS2-2 AKR1B1 HPGDS MITF PPARGC1B HSD11B1 HSD11B2 ANXA5 ANXA8;ANXA8L1 PTGER4 ANXA6 PTGFRN SOX9 S100A10 PTGER2 PRL ANXA3 ANXA4 SCGB1A1 S100A6 EDNRA PPARG EDNRB PTGES PTGER1 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260910%WP4963%HOMO SAPIENS p53 transcriptional gene network RPRM ULBP3;ULBP1;RAET1G;ULBP2;RAET1L SIVA1 PRKAA1 SERPINE1 ICAM1 ISG15 BTG2 SAT1 TIGAR CDKN1A SLC7A11 BBC3 PRKAA2 PIDD1 PRKAG1 PRKAG2 PRKAG3 SESN1 PRKAB2 APAF1 TRAF4 PRKAB1 FUCA1 TP53I3 CDC25C CDC25A DDB2 ULK2 RRM2B ULK1 PTEN TNF CCNE1 POLK TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SESN2 TP53INP1 PMAIP1 SFN LIF MSH2 GADD45A PML XPC SLC2A1 DEPTOR GLS2 CDK2 NOTCH1 CCNG1 FANCC FAS NANOG;NANOGP8 BAX GPX1 NCF2 CX3CL1 POLH ERCC5;BIVM-ERCC5 ALDH4A1 RPTOR CPT1C TSC2 MLST8 IRF9 MTOR CCL13;CCL2 FASLG THBS1 ADORA2B PCNA IRF5 XRCC5 ACAD11 SERPINB5 MGMT SCO2 ADGRB1 ULBP1-2 AURKA AKT1S1 DDIT4 DRAM1 ZMAT3 MLH1 PERP E2F7 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEDS1-UBE2V1;PEDS1 PEX19 LPCAT1 PEX1 PEX7 PEX16 ALDH3A2 PEX5L LPIN3 DHRS7B AGMO DGKQ FAR2 ACAD10 CEPT1 ARSA UGT8 GNPAT GAL3ST1 AGPS LPIN1 LPIN2 FAR1 PEX3 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260910%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 G13 SIGNALING%WIKIPATHWAYS_20260910%WP524%HOMO SAPIENS G13 signaling ARHGDIB CYFIP1 WAS PIP4K2A MAPK10 RTKN SH3RF1 PPP1CB RHPN2 RHOA MYBPH PKN1 CIT RPS6KB1 MAP3K4 PFN1 ROCK1 ROCK2 CDC42 CFL2 PAK3 CFL1 TNK2 LIMK1 DIAPH1 PIK3CD PIK3CB GNA13 ARHGEF1 IQGAP1 ARHGDIG IQGAP2 PIK3R2 PIK3CA CALM1 WASL RAC1 MYL1 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260910%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA2 ITGB2 SELPLG VCAM1 SELE MADCAM1 ITGB7 ITGB1 ICAM1 ITGA4 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260910%WP2197%HOMO SAPIENS Endothelin pathways PRKCA GNAI1 GNG13 NPY PTGIR NPY1R GNAS-1 EDN1 PLCB1 ATP2A2 CNN1 RIIAD1 ADRA1A RAMP1 CALCA ADRB1 RAF1 GNA15 MYLK CALCRL CAD NOS3 ADCY10 GNB5 ECE1 EDNRA EDNRB MAP2K2;MAP2K1 CALM1 MAPK1 MYL1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260910%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK CYP2E1 MAPK8 SP1 MAP2K2;MAP2K1 MAFF NFE2L2 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260910%WP438%HOMO SAPIENS Non homologous end joining XRCC6 NHEJ1 XRCC4 XRCC5 LIG4 PRKDC POLM POLL WRN DCLRE1C CILIOPATHIES%WIKIPATHWAYS_20260910%WP4803%HOMO SAPIENS Ciliopathies TCTN2 CSPP1 GAS8 TCTN1 BBS9 LCA5 BBS7 CEP290 CLUAP1 CC2D2A BBS5 RPGRIP1L TMEM138 RP2 CCDC65 TMEM216 ANKS6 CEP104 ARL3 ARL13B TMEM67 INPP5E NPHP1 PDE6D NPHP3 AHI1 PIBF1 RSPH9 NEK8 BBS2 BBS1 NEK9 MKS1 CPLANE1 TMEM231 TTC8 TMEM17 RSPH3 KIAA0586 TMEM237 UNC119 B9D1 EVC2 CEP41 B9D2 TTC21B GLI2 KIF7 EVC INVS RSPH4A RSPH1 KIAA0753 OFD1-1 OCRL BBS4 ZIC2 CRX ODAD1 GALNT11 ODAD3 ODAD2 ODAD4 MCIDAS TBC1D32 NEK1 NEK2 DNAAF3 ADCY6 IFT172 DNAAF2 DNAAF1 DNAAF6 DNAAF5 DNAAF4 CFAP410 RP1-2 FAM161A MAK CFAP298;CFAP298-TCP10L CCNQ TRAF3IP1 CCNO AK7 GLIS2 PKHD1 CEP78 INTU DNAH11 CEP19 DCDC2 C8orf37 GPR161 ARL2BP DNAL1 ALMS1 WDPCP HYDIN TAPT1 CCDC39 ARL6 DDX59 BBIP1 CFAP52 TTBK2 DNAI2 POMGNT1 TOPORS NME7 NME9 USP9X CEP83 EFHC1 ZMYND10 SMO KIZ C2CD3 CFAP53 KATNIP CCDC103 PKD2 TMEM107 DNAH6 MKKS PKD1L1 POC1A BBS10 POC1B PIK3R4 BBS12 RAB28 XPNPEP3 CILK1 DNAI1 TUB PCARE RPGRIP1 RAB23 RP1L1 SCLT1 TTLL5 CNGA1 CENPF SPAG1 HYLS1 ATXN10 TRIM32 DYNC2H1 DYNC2I2 PLK4 LZTFL1 DYNC2I1 CNGB1 IFT140 SPATA7 DYNLT2B WDR19 IFT122 IFT80 WDR35 DYNC2LI1 IFT43 IFT81 IFT27 PKD1 TULP1 GLI3 DRC1 IFT52 ZNF423 IFT57 IQCB1 DNAJB13 FLCN CCDC40 CEP120 CEP164 TCTN3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP3995%HOMO SAPIENS Prion disease pathway MAPK3 RXRA SPI1 STAT3 ELK1 EP300 SMC3 PDIA3 POU2F2 RFX5 BATF CASP3 BCL2 EBF1 RAD21 CREB1 FGFR1 FYN PAX5 PRNP IRF4 HSP90B1 NCAM1 HSPA5 BCL11A PTK2 CTCF MEF2C TBP CHD2 NFKB1 MAPK1 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260910%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis RPL11 MAPKAP1 MLST8 PTEN FOXO3 AKT2 AKT3 AKT1 TP53 MTOR EGFR RICTOR RIOK2 PIK3CA RIOK1 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260910%WP3877%HOMO SAPIENS MYD88 distinct input output pathway MYD88 TRAF6 IL1A TLR1 TLR9 TLR5 TLR8 TLR6 TLR2 TLR7 TLR10 TLR4 IRAK1 UBE2N JUN NFKB1 TIFA UBE2V1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260910%WP4172%HOMO SAPIENS PI3K Akt signaling CD19 PRKAA1 ATF2 IKBKB FGF21 JAK3 CHUK RHEB RELA PRKAA2 EGF FN1 EPO TNC CCND1 MYC KDR PDGFB PDGFRB FGF2 ATF4 KIT IGF1 EIF4E BCL2 CREB3L2 RAF1 AKT2 AKT3 AKT1 MTOR GSK3B TCL1B PIK3R2 TCL1A PIK3R1 PPP2R1B PPP2R1A DDIT4 PPP2R2A;PPP2R2D MAP2K2;MAP2K1 EPHA2 MAPK1 RAC1 LPAR2 JAK2 LPAR3 IL6R LPAR4 GNG10 PDGFD MAPK3 PDGFC JAK1 NGFR GNG13 SGK3;C8orf44-SGK3 COL1A1 COL1A2 LPAR5 BAD LPAR6 GYS2 GNGT1 GYS1 IKBKG OSMR IL6 PHLPP2 IGF1R RPS6KB1 TNXB GRB2 PHLPP1 SOS1 RELN BCL2L1 VEGFB OSM VEGFD KITLG FGF20 CHRM2 CSF3R FGF23 IL2 STK11 FGF22 IBSP IL4 TNN FGF17 TNR PDGFRA FGF19 F2R FLT4 COL4A2 TLR4 COL4A1 PTEN EIF4E1B COL4A4 COL4A6 FGF1 CSF1R FGF3 FGF4 SOS2 FGF5 EFNA4 EGFR FGF6 HSP90B1 FGF7 VTN FGF8 CHAD FGF9 EFNA1 EFNA3 EFNA2 FGF14 GNB2 PRKCA GNB1 RPS6KB2 GNB4 EFNA5 GNB3 IL7R FGF13 FGF12 FGF11 HSP90AB1 LAMC3 LAMC2 PIK3R3 LAMC1 PIK3R6 GHR PIK3R5 HSP90AA1 VWF PPP2R5B PPP2R5A PPP2R5D NGF COL6A2 IL3RA EIF4E2 CREB5 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 ITGA2B GNG2 GNG5 FGF18 PPP2R3C PPP2R3B FGFR4 GNG4 GNG8 FGFR3 EIF4B FGFR2 ANGPT4 LAMB3 TLR2 FGF10 NOS3 FGFR1 LAMB2 LAMB1 FOXO3 PPP2R3A BCL2L11 PIK3CD EPOR PCK2 PIK3CB PPP2R2C G6PC1 PIK3CG PPP2R2B FASLG TEK PPP2R5E PPP2R5C NTRK2 PTK2 PIK3CA ITGA10 FLT1 ITGA11 ITGB1 PGF ITGB5 ITGB4 ITGB3 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 PKN3 PDPK1 ITGA3 ITGA2 PKN2 ITGA1 CDKN1A PKN1 CDKN1B ITGA8 G6PC2 BRCA1 G6PC3 ITGA7 NTF4 ITGA6 FLT3LG CASP9 ITGA5 CCND3 CCND2 ITGA9 COMP CREB1 COL9A1 CCNE2 COL9A3 COL9A2 CCNE1 IFNB1-4 TP53 GNB5 MDM2-2 IL3 IL7 LAMB4 CDK6 CDK4 CDK2 CHRM1 IRS1 BDNF INS;INS-IGF2 PPP2CB;PPP2CA IFNAR2 TSC2 FLT3 RBL2 IFNAR1 PRL IL2RG RPS6 IL4R PRLR NFKB1 EIF4EBP1 IL2RA IL2RB CSF3 NTRK1 HGF SGK1-1 CREB3L3 CREB3L4 CREB3L1 SYK PDGFA TGFA INSR ATF6B SPP1 MYB CSF1 VEGFA MCL1 LPAR1 IGF2 NRAS HRAS KRAS THEM4 COL6A1 COL6A3 COL6A6 COL6A5 PCK1 PIK3AP1 MET RPTOR COL4A3 COL4A5 NTF3 MLST8 COL2A1 CDC37 ANGPT2 TSC1 ANGPT1 THBS1 VEGFC CREB3 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260910%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY6 ADRB2 ADCY3 ADCY5 ADCY8 ADRA2C ADRA2B ADRA2A ADCY10 ADCY9 ADCY1 ADCY4 ADCY2 ADRB1 ADRA1D ADCY7 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CSRP2 CCND1 CDH1 MACROH2A1 CDK4 TULP3 MED1 CTNNB1 RB1 E2F1 CDK8 PMAIP1 JAG1 SOX4 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders BHMT ADK CSAD AHCY MAT1A MAT2B CTH MTR-1 GNMT CDO1 CBS;CBSL NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260910%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT8 PRMT7 NOS2 PRMT3 DDAH2 NOS1 NOS3 PRMT5 DDAH1 PRMT2 PRMT1 CARM1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation NDEL1 CDK5 DCTN3 PAFAH1B1 DCTN1 YWHAE YWHAB TH YWHAQ DCTN6 YWHAH DDC DCTN4 YWHAG DYNC1H1 YWHAZ DCTN5 DCTN2 PPP2CB;PPP2CA DISC1 DBH 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome TRIM74;TRIM73;TRIM50 TMEM270 GAPDH-1 DDX21 CTNNB1 RB1 CLDN4 CLDN5 CLDN3 DLD DLST MYC SNAP25 ULK1 CLTC ATF4 UBE2L6 EIF2AK3 HDAC6 VAMP2 HDAC2 MYBBP1A FAS SF3B1 ACACA RFC5 ACACB RFC2 OGDH BRD4 STX1A ATP5MC2 ATP5MC3 EIF2A ATP5MC1 ATP5F1A UBE2E1 ATP5F1B NUP62 HDAC3 MAPK3 PRKG1 BAZ1B ATP5PB MYO1C ATP5F1D ERCC6 ATP5PO SMARCA5 DEK CDKN1C GRB2 FBN1 USF1 BTK BECN1 CFL1 PKLR NRG1 SQSTM1 GRIP1 HSPA2 WNT2 EIF4H CLDN1 FZD9 CLASP1 ABHD11 LIMK1 GTF2I UBE2E3 CLIP2 DNAJC30 FKBP6 VPS28 UBIAD1 TSG101 ATPAF2-2 FBLN2 FBLN5 HOXC8 TBL2 GTF2IRD1 BCL7B PCNA BUD23 VPS9D1 VPS37C VPS37D VPS37A VPS37B LAT2 CHTF18 METTL27 ATPAF1 MVB12A CLASP2 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260910%WP2333%HOMO SAPIENS Trans sulfuration pathway GOT1-1 GCLM DNMT1 CSAD AHCY MAT2B CTH MTR-1 MPST CBS;CBSL GLUCURONIDATION%WIKIPATHWAYS_20260910%WP698%HOMO SAPIENS Glucuronidation PGM2 UGT2A1 PGM5 UGDH UGP2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PGM1 HK1 UGT1A1;UGT1A6 PGM3 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260910%WP5166%HOMO SAPIENS Glyoxylate metabolism ALDH4A1 LDHA SLC26A1 PXMP2 GOT2-1 HAO1 GRHPR HOGA1 DAO PRODH2 AGXT ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260910%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance SLC2A4 INSR ACSL1 MAPK8 CD36 PRKCZ TNF AKT1 MAFA TNFRSF1A SMPD3 ERN1 IRS1 RPS6KB1 EIF2AK2 IRS2 TRAF1 PIK3R1 CPT1B INS;INS-IGF2 PPP2CB;PPP2CA PDX1 PRKAG3 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260910%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells CD63 SPP1 SOD1 BIRC5 KDR CD81 SORBS2 ETS2 STAT3 PTEN TLR4 GATA4 HSPB1 IL6 EGFR MMP9 PDLIM5 EGF IGF1 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260910%WP3944%HOMO SAPIENS Serotonin and anxiety related events PLCD4 NLGN1 HTR2A FOS PPP3CA ARC PLEK GRIN2D CRHR1 PRKCB CRH HTR1A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260910%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases ASAH1 KDSR SGPP1 SPHK2 SPHK1 SGPP2 SPTLC1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260910%WP5053%HOMO SAPIENS Development of ureteric derived collecting system EYA1 BMP4 GRIP1 BMP2 SMO WNT11 ETV5 GDNF CELSR1 BMPER GPC3 CRIM1 RET GFRA1 BMP5 CTDNEP1 FRAS1 FREM1 FREM2 ITGA8 SMAD1 ANOS1-1 GLI1 CCND1 SIX1 SALL1 SIX2 RARG BMPR1A FST BMP7 BMPR2 GLI2 SHH GDF11 GLI3 HOXD11 DCN HOXA11 PAX2 RARA RARB TGFB2 ETV4 SPRY1 TGFB1 MYCN VANGL2 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260910%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GOT1-1 SLC2A1 PC ALDOA HK2 LDHA GAPDH-1 PGAM1 PKM PGK1 SLC2A2 ALDOC ENO1 HK1 PFKM HK3 SLC2A5 GCK ENO2 DLAT ENO3 MPC2 PFKP DLD FBP2 LDHAL6B TPI1 PCK1 SLC2A4 PFKL ALDOB LDHB PDHA1 FBP1 LDHA;LDHC MPC1 PKLR PGAM2 G6PC1 MDH2 MDH1 GOT2-1 GPI ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260910%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B PYCARD CASP1 NLRP3 RELA TRAF3 NFKB1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260910%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX15 GGT1 ALOX12 PLA2G5 LTC4S PLA2G6 PTGS1 DPEP1 JMJD7-PLA2G4B;PLA2G4B ALOX5 LTA4H PTGDS CBR1-1 PTGIS PTGES2 PLA2G4A ALOX15B PRXL2B ALOX5AP TBXAS1 PTGS2-2 PTGES RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260910%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2B ITPR2 CAMK2D CYP11A1 CAMK2A REN ATF2 CAMK2G AGT GNAQ PLCB2 CREB3L3 CREB3L4 CREB5 CALML6 CREB3L1 CALML3 CAMK1D CALML4 CAMK1G CYP11B1;CYP11B2 CREB3L2 CTSG CALM3;CALM1 ATF6B STAR ATF1 HSD3B1;HSD3B2 CMA1 CREB1 CAMK1 CAMK4 ATF4 ACE AGTR1 AGTR2 CREB3 CYP21A2 ITPR1 CALM1 CALM2 ITPR3 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260910%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma JAK2 JAK1 EREG BTC NRAS HRAS STAT3 TYK2 JAK3 RHEB KRAS GRB2 SOS1 EGF RAF1 TGFA RPTOR TSC2 PDK1 PTEN AKT2 AKT3 AKT1 MTOR TSC1 SOS2 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism SLC2A4 ACADM SOD2 STK11 ACLY NOS3 AKT2 PPARA MTTP HADHB-1 ESRRA APOB ESR1 PPARGC1B TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260910%WP3851%HOMO SAPIENS TLR4 signaling and tolerance MYD88 TRAF6 MAP3K7 IRF3 IKBKB RIPK1 IRAK3 IKBKG CHUK TICAM1 IL6 INPP5D TRAF3 NFKBIA CXCL8 TIRAP TRAM1 TLR4 TNF IFNB1-4 IRAK1 TBK1 IRF7 IRAK4 IKBKE NFKB1 TAB2 TAB1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260910%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1C CHRNB4 CHRNA3 CACNA1G RANKL RANK SIGNALING%WIKIPATHWAYS_20260910%WP2018%HOMO SAPIENS RANKL RANK signaling TRAF6 MAP3K7 MAPK9 MAPK3 STAT1 MAPK14 SPI1 IKBKB IKBKG CHUK GAB2 FOS CBL TNFSF11 RELA TRAF2 LYN SYK PAPSS2 NFKBIA MITF SRC CDC42 RELB SQSTM1 TAB2 TAB1 MAPK8 PLCG1 MAP2K7 TRAF5 TRAF1 MAP2K6 JUN TRAF3 TNFRSF11B TNFRSF11A NFATC1 AKT2 AKT1 MTOR PIK3R2 PIK3R1 PTK2 FHL2 MAP2K2;MAP2K1 NFKB1 MAPK1 NFKB2 RAC1 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260910%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism FMO3 CHDH ALDH7A1 SLC44A1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260910%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis DLL1 DLL3 EPHA4 MESP2 NOTCH1 LFNG TBX6 HES7 RIPPLY2 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260910%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria NDUFA9 DMAC2L ATP5PF UCP1 NDUFA8 NDUFA7 NDUFA6 ATP5PD NDUFA5 NDUFA4 ATP5PB NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 UQCRB NDUFA12 UQCR11 COX6A1 UQCR10 COX6A2 SDHC SDHD UQCRQ SDHA UQCRC1 UQCRFS1 SDHB SLC25A5 COX6B1 SLC25A6 UQCRC2 COX7A2 ATP5IF1 COX7B SLC25A14 COX4I1 SLC25A27 UCP3 COX7C UCP2 ATP5F1C COX8A COX7A2L-1 NDUFB3 COX5B COX5A COX6C SLC25A4 COX11 NDUFA11 NDUFA10 NDUFA13 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 COX17 NDUFB4 NDUFB2 ATP5MC2 NDUFB1 SCO1 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 SURF1 NDUFV2 ATP5MG COX15 NDUFV1 ATP5ME DNA MISMATCH REPAIR%WIKIPATHWAYS_20260910%WP531%HOMO SAPIENS DNA mismatch repair RFC1 POLE2 RPA3 POLE3 POLD3 POLD4 POLD1 POLD2 LIG1 PMS2 PCNA EXO1 MSH6 RPA1 POLE RFC5 MSH2 RFC3 RFC4 RPA2 MLH1 RFC2 POLE4 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling RASA1 MAPK3 MAPK8 HRAS STAT3 ELK1 GAB1 PTPN11 MAP4K1 ITGA1 HGF FOS RAPGEF1 GRB2 PTGS2-2 JUN SOS1 CRK DOCK1 CRKL SRC RAF1 MET PAK1 PTEN PXN RAP1B RAP1A PTK2B PTK2 PIK3CA ITGB1 MAP2K2;MAP2K1 MAPK1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260910%WP4537%HOMO SAPIENS Hippo YAP signaling CXCL10 MINK1 STK38L TNIK STK3 SAV1 YAP1-1 TEAD1 WWTR1 MAP4K3 TEAD3 MAP4K4 TEAD4 LATS2 MAP4K1 MAP4K2 MST1 NDRG1 LATS1 NF2 TEAD2 RASSF1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260910%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG16L1 ATG13 ZFYVE1 ATG16L2 PIK3R4 ULK2 ULK1 MTOR MAP1LC3A ATG3 RB1CC1 ATG10 WIPI1 ATG12-1 PIK3C3 BECN1 ATG4A ATG7 ATG5 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260910%WP272%HOMO SAPIENS Blood clotting cascade SERPINE1 SERPINB2 KLK1 PLAT F11 PLAU F10 VWF FGB FGA F13B FGG SERPINF2 F12 F2 F3 F7 F5 PLG F8 KLKB1 F9 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260910%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling CREBBP AR BAD CTNNB1 IKBKG CDKN1A CDKN1B KRAS GRB2 CASP9 FOXO1-1 CREB3L1 SOS1 NFKBIA BCL2 TCF7 PDGFA RAF1 CCND1 PDGFRB AKT3 TP53 MDM2-2 MTOR GSK3B PIK3CA MAP2K2;MAP2K1 KLK3;KLK2 NFKB1 MAPK1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer MAP3K7 ATF3 MACROH2A2 WNT11 DKK1 HNRNPU SOST WNT7B PLAU TFAP2A CTNNB1 TPTEP2-CSNK1E;CSNK1E FRAT2 CSNK2A2 CCND3 SFRP4 CCND2 CSNK2B TCF7 DVL1 DVL2 FOSL1 HNRNPK CCND1 MYC DVL3 DKK2 DKK4 RUVBL1 FZD10 APC2 AXIN1 AXIN2 CSNK2A1;CSNK2A3 SOX17 CER1 LEF1 SERPINF1 CTNNBIP1 SFRP1 SFRP2 SFRP5 CTBP2 CTBP1 TCF7L2 PORCN TCF7L1 WNT5B CSNK1A1 RYK-1 APC KREMEN1 SENP2 ROR1 ROR2 CDK6 CXXC4 NKD1 NKD2 WIF1 NOTUM EZH2 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 JUN FZD5 FZD7 FZD6 FZD9 FZD8 FZD1 FZD3 WNT3A WNT5A WNT7A CHD8 WNT2B WNT3 LRP6 GSK3B CDK8 WNT16 NLK LRP5 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B1 F13B HSD17B2 HSD17B3 CYP17A1 HSD3B1;HSD3B2 CPN1 HSD17B7 HSD17B4 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260910%WP5193%HOMO SAPIENS Cholesterol synthesis disorders SQLE HSD3B1;HSD3B2 IDI1 CYP51A1 EBP MVK SC5D DHCR24 MSMO1 DHCR7 LBR MVD HMGCR HMGCS1-1 PMVK FDFT1 FDPS LSS GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260910%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis IL2RA CCR6 ITGAV BLK SLC22A4 CIITA FCRL3 PTPN22 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PADI4 CD244 PHF19 CTLA4 IRF5 TRAF1 IL6ST CD40 STAT4 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260910%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2;SMAD3 GLI3 TGIF2 FGF8 FOXG1 NKX2-1 TGIF1-1 NODAL SHH LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260910%WP5314%HOMO SAPIENS Lactate shuttle in glial cells SLC2A1 LDHB LDHA NUDT14 SLC1A2 SLC4A4 CA2 HK1 CA4 SLC16A1 SLC16A7 SLC16A3 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260910%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits TNC VCAM1 NOTCH1 PIK3CG WNT2 LEF1 POSTN CYTIP CXCR4 VEGFA JAG1 TCF7L2 TCF7L1 VHL TCF7 EPAS1 SRC INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260910%WP5120%HOMO SAPIENS Inclusion body myositis NCSTN MSTN SIRT1 PSEN1 MAPT PSENEN APP BACE1 PSEN2 NFKB1 NFKB2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260910%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT1 SGMS1 SGPL1 B3GALT2 B3GALT1 GALNT1 SGPP2 SGMS2 CERS3 UGT8 UGCG KDSR CERK SGPP1 B4GALT2 SPHK2 B4GALNT1 B3GALNT1 SPHK1 GALNT16 ST6GALNAC3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260910%WP4630%HOMO SAPIENS Measles virus infection HSPA6 IRF3 MAPK9 MAVS IKBKB MAPK10 JAK3 CHUK CDKN1B FOS BBC3 RELA CASP9 EIF3H CCND3 CCND2 STAT5A STAT5B NFKBIA CASP3 CCND1 HSPA8 APAF1 CCNE2 CCNE1 IFNB1-4 TP53 CYCS-1 IRAK1 EIF2AK3 EIF2AK2 BID RCHY1 CLEC4M;CD209-2 TAB2 RAB9A NECTIN4 RAB9B MYD88 CDK6 IL1B CDK4 CDK2 MAPK8 SLAMF1 CASP8 FAS BAX TRADD FADD JUN BCL2 IFNAR2 STAT2 ADAR MX1-1 OAS1 IRF9 IFNAR1 IL2RG PIK3R2 PIK3R1 IRAK4 NFKB1 NFKB2 RACK1 TRAF6 CBLB MAP3K7 IL2RA IL2RB NFKBIB JAK1 STAT1 BAD CD3G STAT3 IL12B EIF2S1 CD3E TYK2 IKBKG IL6 CD3D CSNK2A2 CSNK2B BCL2L1 MSN IL2 IL1A OAS3 TLR9 IL12A TLR7 TLR4 CSNK2A1;CSNK2A3 EIF2AK1 EIF2AK4 IRF7 BAK1 CD28 HSPA2 PIK3R3 TRAF3 TNFAIP3 TLR2 PIK3CD PIK3CB TP73 HSPA1A;HSPA1B FASLG IFIH1 TBK1 PIK3CA HSPA1L IKBKE DDX58 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260910%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA VDR COPPER METABOLISM%WIKIPATHWAYS_20260910%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC11A2 SLC31A1 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260910%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IRF3 NFKBIE IL1B NLRX1 STING1 IFNB1-4 IKBKB CHUK IKBKG CGAS REL RELA NLRP3 F3 TBK1 ITPR1 NFKBIA NFKB1 IKBKE GSDMD FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260910%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins ARHGDIB NFX1 MAP3K7 MAPKAPK2 LMNA MAP2K4 PRKDC MAPK8 CASP8 FAS PARP1 FADD RB1 LMNB1 ACTG1 ACTA1 CASP9 JUN MAP3K1 CASP3 BCL2 DFFB DFFA PAK1 FAF1 APAF1 PAK2 IL1A RIPK2 CFLAR TNF ACTB-1 CYCS-1 HSPB1 FASLG DAXX CASP7 CASP6 CASP10 MAPKAPK3 LMNB2 SMIM40 SPTAN1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway DNAJC7 EHHADH-1 CYP2B6 NCOA1 RXRA CYP2A13;CYP2A6;CYP2A7-1 NCOA6 PPARGC1A ALAS1 HSP90AA1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 NR1I3 ABCC2 FOXO1-1 GSTA3;GSTA5;GSTA1;GSTA2 PTPA SMC1A SP1 NCOA2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2A1-4 ABCB1 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260910%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2L12 MYC BCL2L13 BCL2L14 BCL2L15 BOK BCL2L10 BAX AKT2 BCL2A1 AKT3 AKT1 BCL2L2 PIK3CG GSK3B ITGA6 BAK1 BID GSK3A MCL1 BCL2L1 BCL2 ITGB4 PTHLH INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CCL4L2;CCL4L1;CCL4 MYC BMI1 CD96 CSF2 PVR NCR1-1 PRF1 IFNG NCR3LG1-1 CCL5 CCL1 TNF CD226 GATA2 TIGIT CCL13;CCL2 ADAM17 FCGR3A;FCGR3B KLRC4-KLRK1;KLRK1 FOXO1-1 GZMH;GZMB-1 CCL3L1;CCL3L3;CCL3;CCL18 ADAM10 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260910%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response C3-1 ITGB2 SELPLG VCAM1 ITGAL KNG1 IL1A SELP C6 C7 ICAM1 ITGA4 TNF IL6 ITGB1 C5 CXCL8 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260910%WP4707%HOMO SAPIENS Aspirin and miRNAs MVD WNT1 ABCC4 PPARA PTGS1 PTGS2-2 VEGFA NOS3 PDK1 NFKB1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260910%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway PLPP2 SGMS1 DEGS2 ASAH1 CERS3 CERS5 CERS6 CERK CERS1 SPHK2 SPHK1 SGPL1 SGPP2 PLPP1 SPTLC1 SGMS2 UGT8 UGCG KDSR CERS4 SGPP1 DEGS1 CERS2 SMPD1 PLPP3 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260910%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GAPDH-1 GRM3 MBD5 SDCBP SLC6A8 ORAI1 HOMER1 SRC CACNG8 CACNG2 AP2A1 AP2A2 GRIN2A GRIN2C GRIN2B GRIN2D SLC32A1 GLUL AP2B1 SLC1A6 GLS2 GRIA3 GAD1 GRIA4 SLC1A3 FRMPD3 ABAT GRM5 ADARB1 GRIK5 ZFYVE27 GRIK3 CRTC1 SH3GL2 GRIK4 SLC6A12 GRIK1 SLC1A7 GRIK2 NETO2 CPEB3 GRM2 GRM4 NPTN GRM7 C1QL3 GRM8 C1QL2 PLCB1 NWD1 SNX27 UBQLN4 ATAD1 SYVN1 LHFPL4 SNX14 PPP2CB;PPP2CA NR4A1 SLC12A5 SLC6A1 CABIN1 GRIN1 GRM6 KIF5C GRIN3B GRIN3A HDAC1 GABRR3 GABRR2 GABRR1 MAP2K2;MAP2K1 MAPK1 SUMO1 MAPK3 CREBBP GNA11 STAT1 ERBB4 STAT3 P4HB CDH2 SLC7A11 SLC1A2 SLC6A6 SLC1A1 GABRB3 MAP1LC3B2;MAP1LC3B-1 GABRB2 GABRB1 GABRG3;GABRG2 NRG1 GABRE GABRD GABRQ GABRA2 PRKCA GABRA1 GRIP1 GABRP GABRA6 GRIA1 GABRA5 GABRA4 GABRA3 SLC6A11 GABRG1 CAMK2A EFNB2 NRXN3 GRIA2 GRM1 GNAQ ARC DLGAP3 PICK1 DLG4 FFAR1 PDIA2 HDAC10 STIM1 SLC6A13 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260910%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 MS4A1 C3-1 ITGB2 CD19 PDCD1 CD79A ITGAX ISG15 TNFSF13B LOC110384692;C4A;C4B_2;C4B IL6 CR2 PTPRC SYK STAT5A EBI3 IL10 HSPA8 SH2D1A IL2 IL4 IFNG CD40LG IL12A TLR7 TLR4 TNF CXCL13 CR1L;CR1 BCR XBP1 CXCR5 IFIT2 CCL19 CCL21 LOC102723996;ICOSLG BTLA ICOS IL21 CXCR4 FOXO1-1 CXCL12 ETS1 BACH2 BLNK CD40 PTCRA FCRL5 IFITM3;IFITM2;IFITM1 CD1D TBX21 SLAMF7 AICDA CD22 CCR7 IFNAR2 MAF CD69 PAX5 ZEB2 MFGE8 BCL6 CD80 TMSB10 CD82 IRF4 IRF8 CRP GPR183 PRDM1 SELL KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PCYT1B SGPL1 PTDSS1 CHKA PISD ETNK2 PTDSS2 CEPT1 ETNK1 CHKB PCYT2 PEMT CHPT1 PCYT1A ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP1541%HOMO SAPIENS Energy metabolism MEF2A MEF2B;BORCS8-MEF2B PPP3CA PPP3CB PRKAA1 NCOA1 PPP3CC RXRA MYBBP1A MAPK14 ATF2 PPARGC1A TFAM-1 EP300 PPARD CAMK2G MED1 SIRT1 PRKAA2 FOXO1-1 ESRRA PRKAG1 PRKAG2 PRKAG3 PPARGC1B UCP3 PRKAB2 UCP2 PRKAB1 MEF2D CREB1 NRF1 FOXO3 TFB2M CAMK4 TFB1M PPRC1 PPP3R1 GABPA PRMT1 SIRT3 PPARA GSK3B HDAC1 MEF2C PPARG NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260910%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 NMNAT1 QPRT HAAO KMO TDO2 KYNU AFMID BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260910%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GOT1-1 GATM GPT GLS2 ASL NAGS OTC GAMT F7 ARG1 F10 ASS1 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260910%WP4562%HOMO SAPIENS Canonical NF kB pathway CHUK IKBKG NFKBIE REL RELA NFKBIA NFKB1 IKBKB ATR SIGNALING%WIKIPATHWAYS_20260910%WP3875%HOMO SAPIENS ATR signaling TOPBP1 HUS1 RAD9B RPA3 RPA1 ATRIP RAD1 RPA2 ATR CHEK1 RAD9A NEUROINFLAMMATION%WIKIPATHWAYS_20260910%WP4919%HOMO SAPIENS Neuroinflammation MTOR CHUK NOS2 ASCC1 FOS RELA MAPK8 JUN MAPK14 NFKBIA TLR4 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260910%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling PRKCA RASA1 RASGRP1 PPP3CA PDCD1 PLCG1 NFATC2 ITK DYRK1A NFKBIA PTPN6 LCK IL2 CD8A DYRK2 CD8B;CD8B2 FYN PDK1 PTEN AKT1 CTLA4 GSK3B GSK3A CD28 ZAP70 CSNK1A1 NFKB1 CALM1 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260910%WP5195%HOMO SAPIENS Disorders in ketolysis HMGCS1-1 BDH1 OXCT1-1 ACAT1 ACAT2 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260910%WP4540%HOMO SAPIENS Hippo signaling regulation CDH5 CDH4 CDH3 CDH20 CDH22 PRKAA1 CDH24 NGFR CDH10 GNA11 CDH11 CDH12 NTRK1 PRKCD CDH13 CDH15 CDH17 CDH18 LATS2 CDH19 CTNNB1 CDH6 CDH2 IGF1R CDH16 PRKAA2 PRKAG1 PRKAG2 PRKAG3 TCF7 PRKACB-1 CDC42 PRKAR2B PRKAR2A PRKAB2 INSR PRKAB1 PRKAR1B KDR PRKAR1A PDGFRA GNAI3 FLT4 GNAI2 PDGFRB CSF1R LEF1 EGFR KIT PRKCG PRKCI TCF7L2 PRKCH TCF7L1 PRKCB PRKCE PRKCA PRKCQ STK3 YAP1-1 TEAD1 PRKCZ PLCB3 WWTR1 TEAD3 PLCB4 TEAD4 RHOA GNAS-1 GNAQ MST1 PLCB1 LATS1 PLCB2 NF2 TEAD2 MET SMAD2;SMAD3 CDH1 GNAL FGFR4 PRKACA-1 FGFR3 PRKD3 FGFR2 FLT3 FGFR1 MTOR TEK NTRK2 CDH8 FLT1 CDH9 EPHA2 CDH7 RAC1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260910%WP129%HOMO SAPIENS Matrix metalloproteinases TIMP4 MMP1 MMP21 MMP20 MMP25 MMP24 MMP27 MMP2 MMP28 MMP9 MMP7 MMP3 MMP8 MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 TCF20 TIMP1 MMP15 MMP23B TIMP2 MMP17 TIMP3 MMP19 TNF BSG KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260910%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy VAMP2 FGF13 FGF12 ANK3 CAMK2A BACE1 SCN4B KCNQ2 KCNQ3 NEDD4 PRRT2 DAG1 AKAP5 KCNQ1 PRKACA-1 RAB1A SNAP25 TRAPPC3 SCN2A TRAPPC2;TRAPPC2B SCN8A GIGYF1 TRAPPC6B KCNQ4 KCNQ5 STX1A NEDD4L ITPR1 RAB11A CALM1 PRKCE LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP5171%HOMO SAPIENS Leukotriene metabolic pathway GGT1 LTC4S DPEP1 PTGR1-1 ALOX5 LTA4H DPEP2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DECR2 GGT5 ALOX5AP DECR1 ABCC1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis SRD5A2 AKR1D1 HSD11B1 HSD11B2 CYP21A2 CBR1-1 CYP11B1;CYP11B2 SRD5A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BENZENE METABOLISM%WIKIPATHWAYS_20260910%WP3891%HOMO SAPIENS Benzene metabolism DHDH NQO1 CYP2E1 MPO GSTM1;GSTM2-1 EPHX1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260910%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis COL3A1 COL1A1 YAP1-1 TEAD1 BCAR1 SPARC TEAD3 TEAD4 GPC6 SNAI2 PBX3 TEAD2 EDNRA COL5A1 FN1 THBS2 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260910%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP27B1 NR1H3 CYP7A1 CYP2B6 CYP4B1 VDR CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PPARD ABCC3 ABCD3 CYP26A1 ABCB4 NR1I3 ABCC2 CYP8B1 NR1I2 NR1H4 ABCB11 CYP24A1 ABCG1 ABCA1 ABCG5 RARG CYP2C9;CYP2C19 ABCD2 RARA PPARA RARB CYP2E1 PPARG ABCB1 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP19A1 SRD5A2 HSD17B2 HSD17B3 CYP17A1 HSD3B1;HSD3B2 CYP11A1 SRD5A1 UGT1A1;UGT1A6 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP581%HOMO SAPIENS EPO receptor signaling JAK2 RASA1 MAPK3 STAT1 STAT3 IRS1 PTPRC IRS2 GRB2 SOS1 STAT5A STAT5B SHC1-1 SRC EPO RAF1 PDK1 EPOR AKT1 PIK3CG PTPRU SOCS1 CISH MAP2K2;MAP2K1 MAPK1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4224%HOMO SAPIENS Purine metabolism and related disorders DGUOK ITPA TPMT MAT2A ADA GRM5 PRPS1 ATIC RRM2B ADSL PAICS IMPDH1 HPRT1 MOCOS ADSS2 GART PFAS PPAT XDH PNP-1 AMPD1 APRT AOX1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation ITGB3 CSF3 CSF2 TPO SPI1 VAV1 KLF1 FOS IL6 TNXB KCNH2 RHOH STAT5A EPO KITLG RUNX1 GP9 IL1A CIITA IL5 GATA2 MYB IL3 CSF1 LEF1 ACVR1B CD34 HES6 IL1B NOTCH1 NFATC2 CXCR4 MUC1 THRB LYL1 ITGA2B IRF5 TRAF3IP3 IKZF1 FOSB HMGN5 LMO2 TRIM29 PIM1 GATA1 SEC14L2 NCKAP1L MXI1 NFE2 RIOK3 FLI1 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260910%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK3 EGFR JAK1 STAT3 MAPK1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260910%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260910%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways ITPR2 ADCY8 ETS2 ATF2 MAFF ACTG1 FOS GJA1 ATF5 RYR1 PRKACB-1 PRKAR2B PRKAR2A CACNB3 PRKAR1B PRKAR1A CREB1 CRHR1 ATF4 YWHAE GNB5 YWHAB ACTB-1 YWHAQ GABPA YWHAH ACTA2 ADCY1 SFN CALM1 CALM2 RYR3 IL1B PLCB3 ADM JUN RGS1 CALM3;CALM1 RGS2 NOS1 GABPB1 GRK6 YWHAG YWHAZ ITPR1 NFKB1 ITPR3 CRH CRCP RXFP2 RGS4 ATF3 RGS5 RGS3 RGS6 RGS7 IGFBP4 GNG13 CNN2 PLCG2 GRK5 GRK4 PRKCD CALD1 IGFBP6 PKIB PKIA GPR182 GNGT1 PKIG RGS18 PLCD1 ARRB1 RGS17 RLN2;RLN1 ATP2A3 ARRB2 RAMP2 CNN1 IL6 ATP2A2 RGS19 RAMP3 RGS14 RAMP1 RGS16 RGS20 CORIN GUCA2B RGS10 ADCY4 GUCA2A CALCA ADCY2 RGS11 RGS9 ADCY7 ADCY6 ATF6B PDE4B ADCY5 PDE4D-1 OXT-1 SP1 SLC8A1 ADCY9 GSTO1 IGFBP1 IGFBP3 OXTR PRKCG PRKCH PRKCB MYL4 MYL2 GNB2 PRKCE PRKCA GNB1 LPAR1 GNB4 GNB3 ADCY3 PRKCQ CAMK2B PRKD1 RYR2 ACTC1;ACTG2 CAMK2D PLCG1 CAMK2A PRKCZ RXFP1 IGFBP5 CAMK2G GNAS-1 GNAQ ACTA1 GUCY1A1 ACKR3-2 MYLK2 GNG2 GNG5 ATF1 GNG4 PRKACA-1 GNG8 NOS3 DGKZ IGFBP2 CREB3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP453%HOMO SAPIENS Inflammatory response pathway IL2RA IL2RB COL1A1 COL1A2 LAMC2 LAMC1 TNFRSF1A IL5RA LAMA5 CD40 FN1 THBS3 COL3A1 LCK IL2 TNFRSF1B IL4 IFNG CD40LG LAMB2 LAMB1 IL5 CD86 CD80 IL2RG THBS1 VTN IL4R CD28 ZAP70 CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260910%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer CYP19A1 CDK6 MAPK3 CDK4 CDK2 NRAS PIK3R4 PIK3R3 HRAS PIK3R6 PIK3R5 CDKN1A CDKN1B IRS1 IGF1R KRAS INS;INS-IGF2 ESR1 RAF1 CCND1 RPTOR ERBB2 PIK3CD AKT2 CCNE1 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A MTOR PIK3CG PIK3C2B EGFR PIK3R2 PIK3R1 PIK3CA MAPK1 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260910%WP2261%HOMO SAPIENS Glioblastoma signaling MAPK3 MAP2K4 PLCG2 ERBB3 PRKCD GAB1 PDPK1 EP300 RB1 CDKN1A CDKN1B IGF1R BRCA1 CBL GRB2 CCND2 ERRFI1 FOXO4 SRC CCND1 ERBB2 PDGFRA PDGFRB PTEN CDKN2B BRCA2 CCNE1 CDKN2C TP53 MDM2-2 EGFR E2F1 MSH6 PRKCG PRKCI PRKCH PRKCB PRKCA CDK6 PRKCQ CDK4 CDK2 NRAS PLCG1 HRAS PRKCZ SPRY2 ATM NF1 MDM4 MAP2K7 IRS1 KRAS MAP2K6 MAP2K3 FOXO1-1 RAF1 MET ARAF FGFR2 TSC2 FGFR1 FOXO3 PIK3CD AKT2 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A PIK3CG TSC1 PIK3C2B MAP2K5 CDKN2A PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2876%HOMO SAPIENS Pregnane X receptor pathway DNAJC7 CYP2B6 NCOA1 RXRA CYP2A13;CYP2A6;CYP2A7-1 PPARGC1A HSP90AA1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ABCC4 ABCC2 NR1I2 FOXO1-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SRPX2 SRC GSTA3;GSTA5;GSTA1;GSTA2 NRIP1 PSMC5 NCOA2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 NCOA3 SULT2A1-4 ABCB1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260910%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL3 MYH6 DMD DES TNNI3 ACTC1;ACTG2 TPM4 TPM2 ACTG1 TPM3 ACTA1 ACTN2 ACTN3 MYOM1 TNNI1 ACTN4 TNNI2 MYBPC3 MYBPC1 MYBPC2 TNNC2 NEB MYH3 VIM TNNT1 TNNT3 MYH8 TMOD1 TPM1 ACTA2 TNNC1 TTN-1 TCAP TNNT2 MYL4 MYL2 MYL1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXTL3 CSGALNACT1 B3GAT3 SLC35B3 B3GALT6 SLC35B2 EXT1 CHST14 CANT1 EXT2 BPNT2-1 CHSY1-1 B4GALT7 SLC26A2 XYLT2 XYLT1 PAPSS2 CHST3 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260910%WP5294%HOMO SAPIENS Sildenafil treatment NOS2 PDE4B PDE4A PDE4D-1 GAPDH-1 NOS1 PRKG1 NOS3 PDE5A NRF1 PPARGC1A GUCY1B1 AKT2 PRKN AKT3 ZNF746 TFAM-1 AKT1 GUCY1A2 GSK3B GUCY1A1 PDE4C SICKLE CELL DISEASE%WIKIPATHWAYS_20260910%WP5604%HOMO SAPIENS Sickle cell disease IL18 IL1B HBA2;HBA1 HBD;HBB TLR4 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260910%WP2855%HOMO SAPIENS Dopaminergic neurogenesis STAT3 RET WNT1 CDKN1C SOX2 ALDH1A1 OTX2 GLI1 NR4A2 MSX1 FOXA2 SLC6A3 NEUROD1 EN1 GBX2 LMX1B NEUROG2 ASCL1 GLI2 SHH PITX3 TH NKX6-1 EN2 LMX1A SLC18A2 DDC NKX2-2 FGF8 TGFB1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260910%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 APAF1 CASP8 FAS MAPK10 RIPK1 FADD CYCS-1 TNFRSF1A HSPA1A;HSPA1B FASLG CASP7 CASP9 CASP6 CASP2 BID MAP3K1 AIFM1 NFKB1 CASP3 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260910%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways PGM2 HK2 LDHA GAPDH-1 CEP290 SDS PKM PGK1 CREBBP ALDOC ENO1 HK1 CDH13 PFKM STAT3 HK3 BAP1 EP300 ENO2 RHEB ENO3 PFKP SHMT2 GRB10 VHL LDHB SSPN LDHA;LDHC ACLY KDR PDGFRA PDGFB BHLHE41 PDGFRB CAMK1 PTEN PKLR KDM5C EFCAB3 PLOD2 ENPP3 EGFR PBRM1 TOX2 RAPGEF5 VEGFA SDSL PGBD5 LDHD SQSTM1 KCNJ2 GPI SLC2A1 DEPTOR ALDOA SHMT1 PHGDH HIF1A PGM1 ZEB1 PSPH PSAT1 ACACA ACACB FASN TPI1 ME1 PFKL ALDOB RPTOR TSC2 MLST8 AKT1 MTOR TSC1 MAP2K5 KSR1 MDH1 FLT1 ARNT AKT1S1 SETD2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4571%HOMO SAPIENS Urea cycle and related diseases CPS1 GLS2 ASL NAGS SLC25A13 OTC SLC25A15 ARG1 ASS1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260910%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2;SMAD3 NEDD4 ATG16L1 TGFBR1-1 PMEPA1 LDLRAD4 TGFBR2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5380%HOMO SAPIENS 5q35 copy number variation MAPK9 TPM2 MAPK10 UIMC1 ABRAXAS1 BRCC3 BRCA1 PNPLA2 MAGED1 INPP5D ABHD5 SRC MAX MYC GNAI3 GNAI2 ABL1 BARD1 GRIN2B NTN1 H3-3A MAPK8 KDM6B JUN TMED10 GRIN1 DRD2 PTPN2 TMED2-1 GRK6 PIK3R1 PDLIM7 GAB1 HK3 COX6A1 IGF1R RGS14 GRB2 SOS1 COX6B1 COX7B COX4I1 SNCA COX7C SLC34A1 COX8A FGF19 COX5B COX5A EIF4E1B COX6C B4GALT7 FGF1 NELFB FBXW7 ADAM10 KIAA1191 ARL10 RNF44 UNC5A MYO7B HIC2 GPRIN1 CYP7A1 GNAI1 DOK3 PFN3 PRELID1 PLCG1 PTPRN2 NOP16 HIGD2A MXD3 PRR7 HIP1 FAF2 DDX41 BABAM1 BABAM2 TMED9 CLTB ARFGAP2 CDHR2 FAM193B CDHR5 CXCR4 F12 DBN1 LMAN2 RAB24 ZNF346 SNCB HIP1R SIMC1 TSPAN17 NSD1 ANKS4B FGFR4 EED CAPN3 FRS2 PTH USH1C COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome PDS5B PDS5A WAPL CDK1 PPP2R5B REC8 PPP2R5A SMC3 PPP2R5D AURKB PPP2CB;PPP2CA CDCA5 ESCO1 ESCO2 SGO1 PTPA SMC1A MAU2 RAD21 PLK1 SGO2 STAG2 HDAC8 PTTG1;PTTG2 PPP2R5E SMC1B PPP2R5C ESPL1 NIPBL PPP2R1B PPP2R1A STAG3 APC CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK9 MAPK3 MAPK8 MAPK14 MAPK12 MAPK13 MAPK10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAPK11 FAAH DAGLA CYP1A1 CNR1 PRKACB-1 ADCY7 PRKAR2B PRKACA-1 PRKAR1B NAPEPLD PRKAR1A DAGLB CYP2C9;CYP2C19 ADORA2A CNR2 AHR ADCY1 MAPK1 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation DLL1 RIMBP2 GATA6 HES3 ROBO1 SLC6A5 ITGA6 HOMER1 TNC HNF4A CNP SNAP25 CACNG2 AP2A1 HTR1A AP2A2 MBP SOX9 PAX3 SOX17 PAX6 SLC18A3 CD34 MOG CLDN11 UNC13A GRIN2B PECAM1 SYP OLIG2 SOX10 BMP4 GLUL TPH1 GAD1 SLC1A3 GAD2 SLC6A9 LHX1 SLC17A6 SLC17A7 SOX2 TUBB3;TUBB6 MSX2 ESRRB ACHE NR4A2 NEFL SLC6A1 FOXA2 CDH1 SLC6A2 SLC6A3 GRIN1 SLC6A4 FOXD3 SHANK3 TH CHAT NLGN1 KLF4 DPPA3 NGFR FABP7 NEFM GATA4 KCNJ6 CDH2 SNAI1 SNAI2 SLC1A2 MSX1 FEV GFAP ADRA2C HTR5A ADRA2B ADRA2A MAP2 FGF4 LEF1 TPM1 HES1 GPHN HES5 ZFP42 GABBR2 POU5F1;POU5F1B ALDH1L1 GABBR1 TBXT GLS CASK NOTCH1 NANOG;NANOGP8 MIXL1 NODAL DLG1 DLG2 SHANK1 DLG4 DCX LMX1B RIMS2 PPFIA1 HOMER3 BSN RBFOX3 FBXO15 TBR1 TWIST2 LIN7A FUT4 HOMER2 EVX1 DLG3 CD24 NES PCLO CSPG4 ERC1 DPPA2 ERAS GLRA1 ITGB1 GLRA2 AQP4 GLRA3 GLRB KRT15 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260910%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone CASR GABBR1 GPRC5B GPRC5A GPRC5D GPRC5C GRM3 GRM6 GRM5 GRM1 GRM2 GRM4 GRM7 GRM8 GABBR2 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260910%WP500%HOMO SAPIENS Glycogen synthesis and degradation HK2 PYGB GBE1 UGP2 PYGM PYGL PHKG1 HK1 GYG2 PGM1 PHKB PHKA1 GYS2 HK3 HKDC1 AGL-1 GYS1 PPP2R5B PPP2R5A PPP2R5D PPP2CB;PPP2CA CALM3;CALM1 PPP2R3B PTPA PPP2R3A PPP2R2C PHKG2 PPP2R2B PPP2R5E GYG1 PPP2R5C GSK3B GSK3A PPP2R1B PPP2R1A PHKA2 CALM1 PPP2R2A;PPP2R2D CALM2 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260910%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy SLC2A1 LDHA GAPDH-1 GPD1 HIF1A CD36 GPAT3 PPARG TPI1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260910%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection PRKCA TUBA1C NCK2 EZR TUBA1A WAS LY96 CD14 TUBA3E;TUBA3C-1 CTTN ARPC5L TUBB4A;TUBB;TUBB8B;TUBB8 ARPC1A CTNNB1 ARPC4 RHOA KRT18 TUBA8 ACTG1 ARPC2 ARPC3 ARHGEF2 TUBB3;TUBB6 TUBB2B;TUBB2A ARPC5 CLDN1 NCK1 ROCK1 TUBAL3 ROCK2 CDC42 TUBB4B CDH1 NCL-1 TLR5 ARPC1B FYN TLR4 TUBB1 HCLS1 YWHAQ ACTB-1 TUBA4A ABL1 OCLN-1 YWHAZ ITGB1 WASL COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260910%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C3-1 C8A ACE2 C3AR1 FCN2;FCN1 COLEC11 C5AR1 C6 C7 C9 MASP2 C5 CHOLESTASIS%WIKIPATHWAYS_20260910%WP5238%HOMO SAPIENS Cholestasis TJP2 SCARB1 RXRA EPHX1 ABCC3 HMGCR SLCO1A2 ABCC4 SLC10A1 ABCB4 ABCC2 ATP8B1 NR1I3 SLC22A1 NR1H4 ABCB11 ABCG8 LDLR ABCG5 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome DUSP14 TEC DHRS11 SLC35G4;SLC35G5;SLC35G3;SLC35G6 CWC25 SLFN11;SLFN13 AATF CCL3L1;CCL3L3;CCL3;CCL18 IKZF3 CISD3 RDM1 CCL11 LASP1 ARL5C C17orf98 CACNB1 C17orf50 CCL4L2;CCL4L1;CCL4 GPR179 UNC45B ERBB2 DDX52 LYZL6-1 MRPL45 PPP1R1B SRCIN1 RAD51D SLFN14 ZNF830 CCL14 CCL1 STARD3 SLFN5 GGNBP2 CCL8 TMEM132E FBXO47 MLLT6 HNF1B FBXL20 CCT6B NEUROD2 MIEN1 ZNHIT3 PNMT C17orf78 RFFL LIG3 ASIC2 SOCS7 GAS2L2 CCL16 HEATR9 TAF15 TCAP RASL10B SYNRG PCGF2 EPOP PEX12 AP2B1 MYO19 FNDC8 PLXDC1 GRB7 NLE1 ARHGAP23 TADA2A STAC2 RPL23 SLFN12L;SLFN12-1 CDK12 LHX1 MED1 PGAP3 MMP28 PIGW ACACA CCL23;CCL15 CCL5 CCL13;CCL2 PIP4K2B MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 GPHN MTARC2 XDH MOCS1 AOX1 VOLTAGE GATED SODIUM CHANNEL ACTION POTENTIAL%WIKIPATHWAYS_20260910%WP5594%HOMO SAPIENS Voltage gated sodium channel action potential PRKCA PRKACA-1 AKAP7 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260910%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria H3-3A HDAC2 SUV39H1 MTA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA3 CBX1 CHD4 CHD3 TP53 RB1 SREBF1 LEF1 E2F1 HDAC1 CBX3-1 INPP5K MTA2 MBD3 MBD2 RBBP7 RBBP4 KDM1A CBX5 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260910%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF3 TNFRSF11A IFIH1 MAVS IRF7 TLR8 TLR7 MR1 TLR3 DDX58 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260910%WP5355%HOMO SAPIENS Metabolic epileptic disorders GATM PC HLCS CPS1 HK2 LDHA ASL GAPDH-1 ECHS1 PKM OTC PGK1 ALDOC ENO1 HK1 PFKM ACAT1 HK3 SLC2A5 CBS;CBSL GCDH ENO2 ENO3 MPC2 PFKP DLD FBP2 SHMT2 LDHAL6B SLC25A5 SLC25A1 GPT DHTKD1 LDHB PDHA1 LDHA;LDHC MPC1 CTH PKLR MDH2 GOT2-1 AADAT GPHN ALDH7A1 XDH SLC25A15 GPI GOT1-1 SLC2A1 HADH ALDOA SLC1A5 GLS2 SHMT1 PGAM1 PHGDH MOCS2 SLC2A2 MOCS1 PSPH CDO1 MOCS3 AMT AASS SQOR SLC7A2 SUOX ETHE1 SPCS1 GCK GLUD1;GLUD2 DLAT GLDC PSAT1 TPI1 PCK1 SLC2A4 PFKL ALDOB ACO1 FBP1 SFXN1 PGAM2 G6PC1 MDH1 GAMT ARG1 BTD ASS1 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260910%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway NRP1 ACE2 TMPRSS2 TMPRSS4 FURIN SCARB1 TLR7 CTSV;CTSL SLC6A19 ACAT1 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260910%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds DVL2 TCF4 FZD8 FZD1 TNKS CTNNB1 WNT1 AXIN1 MBOAT1 LEF1 DKK3 GSK3B SFRP4 LRP1 FZD7 CSNK1A1 APC MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAPK3 MAPK7 PRKG1 MAP2K4 MAPK4 MAPK14 STAT3 IKBKB PDPK1 GATA4 AGT CTNNB1 IKBKG CHUK EDN1 IGF1R IL6ST EGF ROCK1 ROCK2 DVL1 MYLK FGF2 TNF HDAC4 HDAC5 HDAC9 HDAC7 MYLK3 LIF NRG1 IGF1 NFATC4 CDK9 CALM1 PRKCB TAB1 MAP3K14 PPP3CA PPP3CB PLA2G2A-1 CAMK2D CTF1 MAPK8 PIK3R3 CDK7 NPPA RHOA PLCB2 MAP2K7 MAP2K6 MAP2K3 EIF2B5 FZD2 RAF1 FZD1 NPPB WNT3A WNT5A FGFR2 LRP6 PIK3CD AKT2 PIK3CB AKT1 MTOR PIK3CG MYEF2 MAP2K5 GSK3B CISH PIK3R2 PIK3CA PIK3R1 TGFB1 RCAN1 IKBKE LRP5 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260910%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation FGB FGA F13B FGG F13A1 F2 PLG IL26 SIGNALING%WIKIPATHWAYS_20260910%WP5347%HOMO SAPIENS IL26 signaling JAK2 MAPK9 IL1B MAPK3 JAK1 EPHA3 CSF2 MAPK8 STAT1 MPO MAPK14 BAX ICAM1 STAT3 TYK2 MMP1 DEFB4A;DEFB4B IL20RA IL6 DCSTAMP RELA TNFSF11 RORC JUN MMP9 NFKBIA DDIT3 CASP3 IL10 CXCL8 SMAD2;SMAD3 NFATC1 IL26 ATP6V0D2 TNF IL33 CCL20 AKT1 IL10RB ACTA2 PIK3CA SOCS3 MAPK1 IL17A CTSK SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260910%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT4A1 SULT2B1 G6PD SULT1B1-1 PAPSS1 SULT6B1 GSR SULT2A1-4 SULT1C3 PAPSS2 SULT1C2 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260910%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2-2 LEPTIN SIGNALING%WIKIPATHWAYS_20260910%WP2034%HOMO SAPIENS Leptin signaling JAK2 SOCS2 EIF4EBP1 PTPN1 MAPK3 JAK1 NCOA1 PRKAA1 PLCG2 STAT1 BAD MAPK14 STAT3 ELK1 IKBKB PTPN11 LEP IKBKG CHUK RPS6KB1 RELA GRB2 PRKAA2 SOS1 STAT5B SHC1-1 ROCK1 ROCK2 ESR1 SRC CDC42 PDE3B ERBB2 SP1 CREB1 PTEN KHDRBS1 SOCS7 GSK3A MAPK8 PLCG1 HRAS RHOA RPS6KA1 IRS1 EIF4E LEPR FOXO1-1 KPNA4-1 ACACA ACACB CFL2 RAF1 NOS3 SH2B1 FYN AKT1 MTOR REL GSK3B CISH RPS6 PIK3R2 PIK3R1 PTK2 SOCS3 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260910%WP4315%HOMO SAPIENS Malate aspartate shuttle MDH1 GOT2-1 SLC1A3 SLC25A11 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260910%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYB5A STAR SRD5A2 HSD17B3 CYP17A1 POR HSD3B1;HSD3B2 CYP11A1 HSD17B6 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260910%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling JAK2 IL6R IL2RA MAPK9 IL2RB MAPK3 F2RL3 JAK1 MAPK7 MAPK6 CREBBP MAPK4 MAPK14 STAT3 MAPK12 MAPK13 MAPK10 TYK2 MAPK11 JAK3 IL20RA OSMR IL20RB CNTFR PTPRC IL27RA IL5RA IL6ST CSF2RB IFNLR1 SRC IL22RA1 CSF3R PDGFRA MAPKAP1 F2R PDGFRB CSF2RA IL10RB EGFR RICTOR MPL PRKCB DEPTOR IL7R IL9R CTF1 MAPK8 IL11RA GHR DUSP2 IL3RA PTPRT MAPK15 PTPRD SETD7 STMN1 IL21R RPTOR IL12RB2 IFNGR1 IFNAR2 TRIM28 IFNGR2 MLST8 MTOR F2RL2 LIFR IFNAR1 AGTR1 IL2RG AGTR2 PIAS3 AKT1S1 SOCS3 IL10RA MAPK1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260910%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IFNK CCL27 IL19 CCL26 IL36A IL36B XCL1;XCL2 EBI3 IL36G AREG EPO IL1F10 IL20 PF4;PF4V1-1 IL26 IL27 CNTF CCL14 CCL1 TNF IL11 CCL8 IL33 CXCL13 IFNB1-4 CCL20 IL15 CCL25 IL3 CCL24 IL31 IL7 IL37 LIF CCL19 CCL16 CXCL2;CXCL3;CXCL1-1 CCL21 CXCL11 IL36RN IL1B CCL17 CCL22 LTA CX3CL1 CCL23;CCL15 MMP3 CCL5 TSLP CCL13;CCL2 IL17D TGFB1 IL17C IL17B NFKB1 CXCL10 CSF3 CSF2 IL12B MMP1 TNFSF13B IL6 IL13 CCL28 MMP9 CCL3L1;CCL3L3;CCL3;CCL18 IFNL2;IFNL3;IFNL1 IL10 OSM CCL11 CXCL8 IL18 CCL4L2;CCL4L1;CCL4 IL2 IL9 IL4 SPP1 IL1A IFNG IL12A IL5 CXCL14 CXCL9 CSF1 CXCL17 VEGFA IL17F PPBP IL17A IL24 CTF1 IL1RN IL21 IL22 CXCL12 IL25 IL23A CXCL5;CXCL6 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260910%WP3878%HOMO SAPIENS ATM signaling in development and disease RAD50 NHEJ1 CDK5 RNF168-1 CDK2 RNF8 PRKDC MAPK14 ATF2 MAPK12 MAPK13 ATM ATR MDC1 MAPK11 TP53BP1 IKBKG MRE11 G6PD PPM1D RBBP8 AURKB CHEK2 PPP2CB;PPP2CA RNF20 ATMIN-1 CHEK1 RNF40 CEP63 NBN STK11 SMC1A TRIM28 CDC25A TSC2 HDAC4 DCLRE1C TP53 MTOR HSPB1 PPP5C HMGN1 BUB1 LMNB2 NFKB1 RIF1 KAT5 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260910%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRG RARA RARB RARG RXRA RXRB IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260910%WP5172%HOMO SAPIENS Iron metabolism disorders CYBRD1 HEPH TFR2 FTL-1 TFRC HFE SLC11A2 TF SLC40A1 FTH1 BCS1L HJV STEAP3 HAMP CP UQCRFS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260910%WP408%HOMO SAPIENS Oxidative stress response TXNRD2 JUNB TXNRD1 MAPK14 MAPK10 FOS CYP1A1 GPX1 GSR GSTT2B;GSTT2 TXN2 GCLC NFIX SOD2 SOD3 NOX3 HMOX1 NQO1 SOD1 NOX5 SP1 UGT1A1;UGT1A6 NFE2L2 CYBB MAOA CAT XDH NOX4 NFKB1 MGST1 NOX1 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260910%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling JAK2 EIF4EBP1 MAPK9 TEC IL7R MAPK3 JAK1 MAPK8 STAT1 MAPK14 STAT3 YES1 PTPN11 GAB2 HCK RELA LYN STAT5A STAT5B NFKBIA BTK FES SRC STAT4 LCK FYN TSLP AKT1 CRLF2 STAT6 RELB RPS6 MAP2K2;MAP2K1 NFKB1 MAPK1 NFKB2 DRAVET SYNDROME%WIKIPATHWAYS_20260910%WP5200%HOMO SAPIENS Dravet syndrome PRKCA FGF13 STXBP1 SCN3B SCN3A SCN1B CAMK2A SCN4B SCN2B MAPK11 PRR5 PRR5L HCN1 SCN1A KCNA2 PCDH19 MAPKAP1 SCN2A MLST8 SCN8A TNF AKT1 SNTA1 MTOR RICTOR PIK3CA CHD2 NFKB1 CALM1 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL1B CSF2 IL12B IL6 LGALS3 LGALS1 IL13 CCL28 CXCL12 MMP9 VEGFB IL10 IL25 VEGFD CXCL8 IL2 LGALS9C;LGALS9;LGALS9B IL4 IFNG IL23A CCL5 REG4 IL12A TNF IL5 CCL20 CCL13;CCL2 VEGFC TGFB2 VEGFA IL17D TGFB1 CXCL2;CXCL3;CXCL1-1 IL17C TGFB3 IL17F CXCL5;CXCL6 IL17B IL17A PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260910%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 BIRC3 CASP8 RIPK3 BAX TRADD TNF RIPK1 FADD CYCS-1 TNFRSF1A CASP7 TRAF2 CASP9 PPP2CB;PPP2CA CASP3 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260910%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair H4C6 NBN RAD51 RNF168-1 RNF8 PRKDC RAD54L ATM MDC1 NASP-1 TP53BP1 SUPT16H XRCC6 XRCC5 H4-16 NAP1L1 SSRP1 SETD2 H4C1 AUTOPHAGY%WIKIPATHWAYS_20260910%WP4923%HOMO SAPIENS Autophagy UVRAG DEPTOR ATG16L1 PRKAA1 ATG101 PIK3R4 ATG9A RB1CC1 PRKAA2 PRKAG1 WIPI2 PRKAG2 BECN1 PRKAG3 AMBRA1 PRKAB2 RPTOR ATG14 PRKAB1 ATG13 MLST8 ULK1 MTOR ATG3 MAP1LC3B2;MAP1LC3B-1 ATG12-1 AKT1S1 PIK3C3 ATG7 ATG5 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260910%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO4A1 HSD17B1 SLCO1A2 CYP19A1 HSD17B2 HSD17B3 ESR2 HSD3B1;HSD3B2 SLCO2B1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO4C1 ESR1 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260910%WP545%HOMO SAPIENS Complement activation C1QB C3-1 C1S CFP C1QC C1R C2 C6 C7 C9 CD55 C8B C8A C8G LOC110384692;C4A;C4B_2;C4B MASP2 C5 MASP1 CFB CFD PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260910%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA TALDO1 RPE;RPEL1 G6PD PGLS DERA TP53 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260910%WP4658%HOMO SAPIENS Small cell lung cancer TRAF6 NFKBIB RXRA ITGAV IKBKB ITGA3 ITGA2 RB1 IKBKG CHUK CDKN1A CDKN1B CDKN1C ITGA6 RELA CASP9 SKP1 TRAF2 BCL2L1 NFKBIA CASP3 FN1 MAX CCND1 MYC NOS2 APAF1 TRAF4 BIRC7 BIRC2 BIRC3 ZBTB17 DDB2 CCNE2 COL4A2 PTEN COL4A1 CDKN2B CCNE1 POLK COL4A4 COL4A6 TP53 CKS1B FHIT CYCS-1 E2F1 E2F2 LAMB4 E2F3 BAK1 BID GADD45B GADD45A GADD45G CDK6 CDK4 CDK2 LAMC3 LAMC2 CASP8 LAMC1 PIK3R3 BAX TRAF5 TRAF1 PTGS2-2 LAMA5 LAMA2 TRAF3 LAMA1 LAMA4 LAMA3 RXRB BCL2 ITGA2B RXRG COL4A3 COL4A5 LAMB3 LAMB2 LAMB1 PIK3CD AKT2 CKS2 AKT3 PIK3CB AKT1 RARB PIK3R2 PIK3CA PIK3R1 PTK2 ITGB1 NFKB1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 IL3 SIGNALING%WIKIPATHWAYS_20260910%WP286%HOMO SAPIENS IL3 signaling JAK2 MAPK3 JAK1 BAD STAT3 PTPN11 CCR3 VAV1 GAB2 FOS HCK RAPGEF1 CBL GRB2 IL5RA INPP5D CSF2RB SOS1 LYN SYK STAT5A STAT5B BCL2L1 SHC1-1 PTPN6 CXCL8 SRC YWHAB YWHAQ IL3 ENPP3 MAPK8 HRAS IL3RA JUN CRKL BCL2 RAF1 PRKACA-1 FYN CD69 PIK3CD CD86 AKT1 PIK3R2 PIK3R1 TGFB1 MAP2K2;MAP2K1 MAPK1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling TRAF6 JUNB MAP2K4 HBEGF MAPK14 ATF2 MAPK12 ELK1 MAPK13 MAPK11 RB1 CDKN1A FOS IL6 MMP2 TRAF2 BCL2L1 CCND1 IL2 IFNG PDGFRA CFLAR TNF CCNE1 BMF TP53 NFE2L2 CCNA2-1 EGFR FGF7 BAK1 BID MCL1 MAPK8 FAS BAX HSP90AA1 TNFRSF1A MAP2K7 TRAF5 MAP2K6 MAP2K3 JUN BCL2 BCL3 BCL2L11 MAP3K5 FASLG CDKN2A TNFSF10 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260910%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer NRP1 CDH5 MAPK3 COL1A1 COL1A2 PLXNA1 PLXNA2 CCN2 CDKN1B HGF SNAI1 SNAI2 MMP2 RELA MMP9 EGF SRC CHD1 KDR CCNE2 BCAR1 CCNE1 SLC39A4 EGFR RELB VEGFA PECAM1 GSK3A CHD2 CDK2 SEMA3A SMAD4 TGFBR1-1 MET SMAD2;SMAD3 AKT2 AKT3 AKT1 TGFBR3 PLXNA4 REL TGFB2 PTK2 FLT1 TGFB3 MAP2K2;MAP2K1 NFKB1 MAPK1 NFKB2 RAC1 TGFBR2 PEPTIDE GPCRS%WIKIPATHWAYS_20260910%WP24%HOMO SAPIENS Peptide GPCRs MC5R OPRL1 CCR9 TACR3 GHSR NPY1R HCRTR2 HCRTR1 CCR3 CCR2 TSHR C3AR1 TACR1 OPRK1 NPY5R CCR8 CCR6 AVPR2 SSTR2 OPRM1 C5AR1 SSTR1 SSTR3 CX3CR1 SSTR4 SSTR5 CXCR6 MC3R OXTR CXCR5 GRPR EDNRA LHCGR EDNRB TRHR FSHR FPR1 MC2R GALR3 GALR2 GALR1 CCR10 NTSR1 NPY2R NTSR2 CCR1 NMBR GNRHR MC1R CXCR4 BDKRB2 NPY4R2;NPY4R BRS3 MC4R CCKAR CCR7 CCR5 CCR4 AVPR1B FPR2 ACKR1 BDKRB1 AVPR1A ATP8A1 CCKBR TACR2 TAC4 AGTR1 AGTR2 OPRD1 CXCR1 CXCR3 CXCR2 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260910%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 ADRB2 MYC ESR2 PAX7 FBXO32 UPF1 PPARGC1A RET EP300 CDKN1A TRIM63 DUX4;DUXA MYF5 VEGFA MYOD1 MYOG CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260910%WP5603%HOMO SAPIENS Caffeine in myocytes MYL3 MYH6 RYR3 RYR2 TNNI3 ACTC1;ACTG2 TPM4 TPM2 ACTG1 TPM3 RYR1 ACTA1 MYH11 TNNI1 TNNI2 TNNC2 MYH3 TNNT1 TNNT3 MYH8 MYLPF MYL6 ACTB-1 MYH13 TPM1 ACTA2 MYH1 TNNC1 MYH7 TNNT2 MYL2 MYL1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260910%WP3963%HOMO SAPIENS Mevalonate pathway MVD HMGCS1-1 HMGCR PMVK FDPS MVK ACAT2 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260910%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways NR1H3 IDI1 EBP CYP51A1 MVK NSDHL SC5D MSMO1 DHCR24 HSD17B7 DHCR7 ACAT2 LBR TM7SF2 HMGCS1-1 PMVK SREBF1 ACOT2;ACOT1 FDFT1 MYLIP FDPS GGPS1 NR1H2 ELOVL3 ACSL3 LSS FASN CH25H ABCG1 ABCA1 HMGCS2 SQLE SOAT1 CYP46A1 SREBF2 FADS2 ACSL1 SCD FADS1 SOAT2 ELOVL4 MVD HMGCR ELOVL2 ELOVL5 CYP27A1 ACSL4 TP53 NETWORK%WIKIPATHWAYS_20260910%WP1742%HOMO SAPIENS TP53 network MYC BOK BAX ATM TP53 MDM2-2 CDKN1A TP73 ABL1 TP63 OTX2 CDKN2A BBC3 PMAIP1 BID TNFSF10 GADD45A BCL2 SUMO1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260910%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TRAF6 PLEKHM1 TNFRSF11A TNFSF11 CLCN7 OSTM1 SNX10 TCIRG1 NFKB1 RAB7A IKBKB RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260910%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 NPR1 IL1B KNG1 PRKG1 SERPINE1 REN VDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AGT RHOA F12 BDKRB2 SERPING1 KLKB1 CPN1 CYP24A1 ROCK1 NOS1 IL1A KLK1 NOS3 TNF BDKRB1 ACE2 ACE AGTR1 AGTR2 NFKB1 MAPK1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260910%WP4742%HOMO SAPIENS Ketogenesis and ketolysis SLC2A1 UCP2 BDH1 OXCT1-1 SLC16A1 ACAT1 CPT2 SLC25A20 HINT1 PATHWAY%WIKIPATHWAYS_20260910%WP5523%HOMO SAPIENS HINT1 pathway TCF4 ERCC3 MAPK9 GTF2H2C;GTF2H2C_2;GTF2H2 ERCC2 RUVBL1 CDK7 MNAT1 CCNH NFATC2 SH3RF1 CTNNB1 FOS JUN KARS1 GTF2H1 GTF2H3 USF2 MITF NFKB1 HINT1 GTF2H4 RUVBL2 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway BCLAF1 MAPK3 NRAS MAP3K2 MAPK14 ATF2 HRAS MAPK11 VAV1 RPS6KA1 GAB2 SPAG1 CBL KRAS GRB2 INPP5D SOS1 CRK SHC4 CRKL SHC1-1 SHC2 BCL2 DOK1 SRC RAF1 ARAF EIF4B BCAR1 AKT2 AKT3 SHC3 AKT1 PXN HSPB1 ABL1 BCR BRAF PIK3R1 PTK2 PIK3CA MEF2C MAPK1 HSPB2 BCL9 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260910%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PMEL TYRP1 ASIP MLANA PLCB3 PLCB4 GNAS-1 ARRB1 POMC GNAQ ARRB2 PLCB1 MC1R PLCB2 ADCY4 ADCY2 MITF PRKACB-1 GNA15 TYR PRKACA-1 DCT CREB1 GPR143 ADCY9 SERPINF1 VEGFA ITPR1 PRKCB IRINOTECAN PATHWAY%WIKIPATHWAYS_20260910%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 CES2 BCHE ABCG2 CES1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260910%WP4830%HOMO SAPIENS GDNF RET signaling axis EYA1 BMP4 GDNF WT1 ROBO1 LHX1 HOXC11 FOXC2 FOXC1 FAT4 RET GFRA1 SOX11 CTNNB1 GREM1 HSPB11 SALL1 SIX2 IFT27 GATA3 HNF1B ROBO2 GLI3 HOXD11 SOX17 HOXA11 PAX2 AGTR2 SLIT2 ALDH1A2 SPRY1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260910%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease H2AZ2;H2AZ1 DES NOTCH3 DMPK LMNA HP1BP3 HSPB3 LBR LMNB1 ACTA1 MEF2C MYOD1 MYOG CBX5 HSPB2 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment NRP1 CXCL10 CSF2 FAS ITGB6 CCR2 CXCR4 CXCL12 IFITM3;IFITM2;IFITM1 CCR5 KDR CCL5 CSF2RA BAG3 CD86 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CSF1R CCL13;CCL2 CSF1 CD80 FASLG HLA-DRA CTLA4 CXCR3 VEGFA TGFB1 LAG3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260910%WP554%HOMO SAPIENS ACE inhibitor pathway CTSG NR3C2 ATP6AP2 KNG1 CMA1 NOS3 REN BDKRB1 AGT ACE2 ACE AGTR1 AGTR2 MAS1 BDKRB2 TGFB1 CYP11B1;CYP11B2 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5407%HOMO SAPIENS 15q11q13 copy number variation TJP3 TJP2 CREBBP SPEF1 SMC5 SMC6 NSMCE3 NSMCE2 CDC42BPB NSMCE1 EID3 GJD3 NECAB3 LYPD6 GJC2 GJA1 UBN1 GCOM1;MYZAP TRPM3 RELA RIC3 APP SLF1 CANX SLF2 FAM189A1 CGN DNMBP MITF APBA2 FANCD2 ANKRD2 CALM1 FANCI STXBP1 TJP1 CXADR MTMR10 KLF13 OTUD7A CHRNA7;CHRFAM7A TRPM1 KAT2B CCL5 SERPINH1 FAN1 STX1A SIN3A HDAC1 OCLN-1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260910%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders POT1 TPP1 H4C6 TERF1-1 TERF2 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TERF2IP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC5 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H2AC20 H2AB2;H2AB3;H2AB1 H4-16 H2BC21 ACD TINF2 H2AC14 H4C1 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5400%HOMO SAPIENS 6q16 copy number variation INSR MC4R SIM1 NPY GHSR GHRL LEP POMC AGRP NTRK2 BDNF LEPR INS;INS-IGF2 ARNT MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies MS4A1 S1PR1 S1PR4 S1PR3 S1PR5 ITGB1 BTK ITGA4 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260910%WP247%HOMO SAPIENS Small ligand GPCRs PTGFR PTGER3 LPAR1 S1PR4 TBXA2R PTGDR PTGIR CNR2 PTGER4 PTGER2 S1PR1 S1PR3 S1PR2 PTAFR CNR1 MTNR1A MTNR1B PTGER1 GPR50 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases HEXB NEU2 GM2A PSAP NEU1 HEXA GLB1 LIPA NPC2 ARSA GBA GALC NEU3 SCARB2 NEU4 NPC1-1 GLA NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260910%WP288%HOMO SAPIENS Nod like receptor NLR signaling CHUK IKBKG MAP3K7 RELA MAPK8 ERBIN EPHB2 CD40 IKBKB EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260910%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways WNT11 MAPK7 MAPK6 MAPK4 WNT7B MAPK12 ELK1 FGF21 CTNNB1 FOS EGF PDGFB PDGFRB FGF2 MDM2-2 HNF1A LIF BMP4 MAP2K6 MAP2K3 JUN RAF1 FZD1 FZD3 WNT3A WNT5A WNT7A ACVR1 WNT3 LRP6 AKT2 AKT3 AKT1 MTOR GSK3B PIK3R2 MAP2K2;MAP2K1 MAPK1 JAK1 STAT3 GAB1 PTPN11 GRB2 ACVR2B IL6ST SOS1 DVL1 PDGFA DVL2 FGF20 DVL3 FGF23 FGF22 FGF17 FGF16 ACTR2 PDGFRA FGF19 SMAD7 PTEN FGF1 AXIN1 FGF3 FGF4 FGF5 FGF6 EGFR FGF7 FGF8 FGF9 FGF14 WNT5B APC FGF13 FGF12 FGF11 HRAS WNT6 WNT1 WNT2 WNT4 WNT10B SMAD1 WNT10A SMAD4 FZD2 FZD5 FZD4 FZD7 FZD6 FZD9 SMAD9 FZD8 ARAF SMAD5 FGF18 FGFR4 BMPR1B FGFR3 FGFR2 BMPR1A FGF10 FGFR1 WNT2B SELENOP BMPR2 PIK3CD NOG LIFR MAP2K5 SMAD6 WNT9B BRAF WNT16 ERAS LRP5 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260910%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport ST20-MTHFS;MTHFS ALDH1L1 MTHFR QDPR SHMT1 SLC46A1 ALDH1L2 MTHFD2L TYMS MTR-1 FTCD ATIC SLC19A1 DHFR2;DHFR FOLR1 MTHFD1 MTHFD2 GART SHMT2 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260910%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis ISCU NARF ABCB7 NUBP1 NUBP2 NFS1 LYRM4 FDX1 FDXR FXN CIAO2B GLRX5 HSPA9 HSCB NFU1 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260910%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TRAF6 IRAK1 RELA TLR2 SPI1 TLR4 APOE NFKB2 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260910%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta PLOD1 ADAMTS2 COL1A1 SP7 COL1A2 WNT1 P4HB LOX BMP1 P4HA1 TNFSF11 P4HA2 CREB3L1 TNFRSF11B FZD1 TNFRSF11A SERPINH1 LRP6 MBTPS1 FKBP10 MIA3 PLOD2 TMEM38B COLGALT1 SERPINF1 IFITM5 CRTAP P3H2 P3H1 MBTPS2 ITPR1 PPIB LRP5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260910%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 STAG1 PTTG1;PTTG2 SMC3 CENPE CDC20 ESPL1 BUB1B BUB3 MAD2L1 BUB1 MAD1L1 APC TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias MAPK9 MAPK3 JAK1 SERPINE1 CREBBP STAT1 ITGB6 STAT3 EP300 CTNNB1 FOS FBN1 EGF SPP1 IFNG SKIL SMAD7 TNF LEF1 LIF ADAMTSL2 LTBP3 ADAMTS10 BMP4 RUNX2 HRAS WNT1 SMAD1 SMAD4 JUN TGFBR1-1 TFE3 SMAD2;SMAD3 SMAD9 SMAD5 RUNX3 ZFYVE9 TGIF1-1 FST LEFTY2;LEFTY1 NOG FOXH1 TGFBR3 ZEB2 ENG LTBP1 THBS1 ZNF423 INHBA SMAD6 FKBP1A SKI BAMBI TGFB1 NFKB1 TGFBR2 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260910%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming POU5F1;POU5F1B MYC KLF4 SOX2 EGR1 TRIM71 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260910%WP5050%HOMO SAPIENS TCA cycle in senescence GOT1-1 PDHA1 MDH1 BRAF PDK1 PDP2 FH ME1 ME2 TP53 SLC25A46 PATHWAY%WIKIPATHWAYS_20260910%WP5521%HOMO SAPIENS SLC25A46 pathway APOOL MMGT1 IMMT MICOS10 APOO CHCHD3 CHCHD6 EMC1 SLC25A46 EMC2 EMC3 EMC4 EMC6 EMC7 EMC8 EMC10 DNM1L MFN1 MFN2 MICOS13 OPA1 IL1 SIGNALING%WIKIPATHWAYS_20260910%WP195%HOMO SAPIENS IL1 signaling TRAF6 MAP3K7 MAPK9 MAPK3 NFKBIB MAP2K4 MAP3K2 MAPK14 ATF2 IKBKB PTPN11 IKBKG CHUK RELA NFKBIA IL1A IL1RAP IRAK1 IRAK2 MAP3K3 TOLLIP SQSTM1 TAB3 TAB2 TAB1 MAP3K14 MYD88 IL1B MAPKAPK2 MAPK8 PLCG1 PRKCZ IRAK3 PELI1 MAP2K7 PELI2 UBE2N MAP2K6 MAP2K3 JUN MAP3K1 UBE2V1 IL1R1 ECSIT AKT1 REL PIK3R2 PIK3R1 IRAK4 MAP2K2;MAP2K1 NFKB1 MAPK1 HSPB2 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260910%WP4217%HOMO SAPIENS Ebola virus infection in host ITGB3 IRF3 VPS11 VPS16 ITGAV ITGA4 EP300 ITGA3 FOLR1 TFAP2A ITGA2 ITGA1 VAV2 ACTG1 ITGA6 RELA ITGA5 FLNA VPS33A ACTN1 ACTN4 CDC42 PAK1 RFC1 CLTC CLTA HLA-DPB1-1 ACTB-1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DOA VPS41 HLA-DOB HLA-DRA HLA-DPA1 EIF2AK2 HLA-DQB2;HLA-DQB1 RELB HLA-DMB HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CLEC4M;CD209-2 RAB9A FLNB FLNC HAVCR2 CLTCL1 MBL2-1 BST2 NPC2 AKT1 MFGE8 ADAM17 REL PIK3R2 PIK3R1 NPC1-1 SOCS3 NFKB1 NFKB2 MAPK1 RAC1 TOP1 MAPK3 RHOB CREBBP STAT1 EIF2S1 RAB5A TPCN2 NEDD4 IGF1R RHOC TYRO3 RASA2 C1QBP GAS6 IL4 EPS15 MERTK PRKRA TLR4 RAB7A IQGAP1 EGFR IRF7 CTSB PIK3R3 ICAM2 GSN ICAM3 KPNA1 TIMD4 RHOA CLEC4G SCIN VPS39 CLEC6A CLTB ASGR1 DAB2IP HLA-DMA CTSV;CTSL AXL TIAM1 PIK3CD TSG101 PIK3CB CAV3 CAV2 CAV1 TBK1 PIK3CA VPS4A ITGB1 IKBKE VPS18 DDX58 ADIPOGENESIS%WIKIPATHWAYS_20260910%WP236%HOMO SAPIENS Adipogenesis UCP1 RXRA FOXC2 PPARGC1A PPARD CTNNB1 RB1 CDKN1A CEBPA CNTFR STAT5A STAT5B KLF6 LIPE CFD E2F4-1 NRIP1 ID3 CELF1 CREB1 TNF NCOA2 GDF10 HNF1A NCOR1 PPARA RBL1 E2F1 LIF GADD45B GADD45A IGF1 BMP4 BMP2 NR1H3 LMNA ZMPSTE24 FAS WWTR1 FRZB SREBF1 IRS1 IRS2 ADIPOQ NR3C1 FOXO1-1 LPIN1 INS;INS-IGF2 LPIN2 NR2F1 DDIT3 RXRG FZD1 EBF1 MEF2D STAT2 SCD CISD1 IRS4 RBL2 SOCS1 RARA NAMPT STAT6 PRLR TGFB1 SOCS3 EPAS1 TRIB3 MEF2A MEF2B;BORCS8-MEF2B ASIP NCOA1 SERPINE1 NCOR2 STAT1 MIF STAT3 LEP GATA4 AGT CYP26A1 IL6 IL6ST SFRP4 NDN CEBPB OSM CYP26B1 DVL1 AGPAT2 BSCL2 LPIN3 SP1 EGR2 CEBPD GATA3 GATA2 KLF15 KLF5 AHR MEF2C WNT5B HIF1A PTGIS MIXL1 WNT1 BMP3 WNT10B BMP1 MBNL1 GTF3A PLIN2 SPOCK1 RORA KLF7 PCK1 SMAD2;SMAD3 SLC2A4 PCK2 PNPLA3 LIFR RETN PPARG LPL PLIN1 DLK1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260910%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 FOXQ1 GPRC5D DKK1 CCN2 GTPBP4 CTNNB1 GJB6 FOS ZBTB16 TP63 MSX1 KITLG IFNG DSC2 DKK4 EGR2 GLI2 GATA3 RBPJ SOX9 GAS1 LEF1 EGFR SFRP1 CD34 S100A4 IGF1 BMP4 TCF4 NOTCH2 KLK6 NOTCH1 WIF1 IGFBP5 KRTAP8-1 BMP6 DKK3 SOX2 SMAD1 SMAD4 NR3C1 ELANE JUN MSX2 FOXE1 HR CD200 HOXC12 PHLDA1 SPINK6 LHX2 SPINK5 KRTAP3-2;KRTAP3-3-1 ADAMTS20 DSG1 FZD1 DSG4 DLX3 PROM1 NFATC1 CASP14 RUNX3 KLK5 WNT5A KLK4 KLK7 BMPR1A CUX1 LRIG1 FST GSDMA KLK13 SOSTDC1 KLK14 BCL11B FOXN1 KRT19 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 LGR5 ADAM17 FOSB NFKB1 PERP KRT15 KETOGENIC DIET IN EPILEPTOGENESIS%WIKIPATHWAYS_20260910%WP5639%HOMO SAPIENS Ketogenic diet in epileptogenesis SLC2A1 HDAC3 HDAC2 LDHA GAD1 ERBB4 HMGCS1-1 GLUD1;GLUD2 HCAR2;HCAR3 TXNIP SLC25A14 SLC25A27 UCP2 AKT3 SIRT4 NFE2L2 HDAC8 KCNA1 ABCC8 PPID HDAC1 NLRP3 RPS6 CAT NRG1 PPARG KCNJ11 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260910%WP2113%HOMO SAPIENS Type III interferon signaling IRF9 JAK1 STAT2 STAT1 IFNLR1 IFNL2;IFNL3;IFNL1 IL10RB TYK2 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260910%WP2007%HOMO SAPIENS Iron metabolism in placenta TFRC ACO1 TF TFR2 SLC11A2 HEPHL1 SLC40A1 MCOLN1 STEAP3 HAMP IREB2 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260910%WP3947%HOMO SAPIENS Serotonin and anxiety GABRA1 HTR2A CAMK2B PPP3CA FMR1 GRM1 HTR1A PLCD4 POMC FOS ARC ADRA1A EEF2K PLEK PRKCB TRPV1 CRH NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260910%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum H4C6 CUL4A GPS1 ERCC3 ERCC4 POLE2 RPA3 ERCC1 POLE3 ERCC2 ERCC8 ERCC6 CUL4B UVSSA BRCA1 RFC1 DDB2 XAB2 POLK CCNH LIG1 LIG3 RBX1 RPA2 XPA XPC H3-3A USP7 XRCC1 PARP1 SLX4 CDK7 MNAT1 CETN2 POLE POLH RFC5 RFC3 RFC4 RFC2 RAD23A RAD23B DDB1 GTF2H2C;GTF2H2C_2;GTF2H2 POLD3 POLD4 POLD1 POLD2 PCNA SLX4IP H4-16 HMGN1 RPA1 GTF2H1 CHD1L GTF2H3 RAD18 GTF2H4 H4C1 POLE4 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G5 PLA2G6 FADS2 ACSL1 JMJD7-PLA2G4B;PLA2G4B FADS1 ACOX1 PLA2G4A ACOX3 ELOVL2 ELOVL5 ACOT2;ACOT1 ACSL3 ACSL4 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260910%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TFAP2A RHOA ARHGEF2 TP63 IRF6 ARHGAP29 TGFB3 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260910%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CYP27B1 MAPK9 MAPK3 JAK1 MAPK7 RXRA PLCG2 STAT1 PRKCD MAPK14 MAPK12 MAPK13 IKBKB ISG15 TYK2 MAPK11 DEFB4A;DEFB4B PLCD1 IL6 CXCL8 IFNG CD40LG SP1 TLR8 TLR4 TNF RELB PRKCG PRKCH PRKCB PRKCE PRKCA PRKCQ CAMK2B CAMK2D NRAS MAPK8 CAMK2A HRAS PRKCZ PLCB3 VDR PLCB4 SP3 MED1 CAMK2G TNFRSF1A PLCB1 PLCB2 KRAS JUN ETS1 NOD2 CYP24A1 CD40 RXRB RXRG IFNGR1 IFNAR2 STAT2 IFNGR2 TLR2 CAMP CCL13;CCL2 IFI44L CAV1 IFI27L2 PLCE1 RSAD2 NFKB1 MAPK1 NFKB2 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260910%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL HMGCS2 BDH1 OXCT1-1 ACAT1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260910%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHC SDHD SDHA SDHAF2 SDHAF3 SDHB SDHAF1 SDHAF4 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260910%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging SIRT1 MTOR IGF1R FOXO1-1 PTEN AKT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260910%WP1531%HOMO SAPIENS Vitamin D metabolism CYP2R1 CYP27B1 CYP27A1 RXRA PTH CYP24A1 RXRB VDR DHCR7 GC CYTOSINE METHYLATION%WIKIPATHWAYS_20260910%WP3585%HOMO SAPIENS Cytosine methylation IDH2 DNMT1 IDH1 MECP2 TET2 TET1 MBD3 TDG CAFFEINE IN NEURONS%WIKIPATHWAYS_20260910%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADORA2A ADRA1D ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias NKX3-2 MGP ADAMTS1 CHST11 ALPL PLAT STAT1 PLAU DDR2 CDKN1C IGF1R CAB39 ACAN MMP9 STAT5B SPP1 KIF3A BMP7 FGF2 IHH HDAC4 IFT88 SOX9 SOX6 SOX5 VEGFA MEF2C IGF1 CALM1 RUNX2 COL10A1 IGF2 GHR FRZB PTH1R HMGCS1-1 BMP6 SCIN THRA CTSV;CTSL PTCH1 SLC38A2 FGF18 ADAMTS5 PRKACA-1 MMP13 RUNX3 FGFR3 BMPR1A SERPINH1 FGFR1 TIMP3 COL2A1 AKT1 GLI3 ENPP1 PTH TGFB2 TGFB1 ADAMTS4 PTHLH PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP4147%HOMO SAPIENS PTF1A related regulatory pathway CTNNB1 RBPJ NKX6-1 PTF1A RBPJL KAT2B NOTCH1 HES1 PROX1 FGF10 PDX1 IL17 SIGNALING%WIKIPATHWAYS_20260910%WP2112%HOMO SAPIENS IL17 signaling JAK2 TRAF6 MAP3K7 IL17RE MAPK3 NFKBIB JAK1 IL17RC STAT3 IKBKB IKBKG TRAF3IP2 RELA TRAF3 CEBPB IL25 SP1 IL17RB CEBPD AKT1 IL17RA GSK3B IL17RD IL17D PIK3CA IL17C IL17F IL17B NFKB1 MAPK1 IL17A MAP3K14 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260910%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes NRP1 BCKDHB RHEB CACNA2D1 CCND1 VCAM1 GNAI2 FGF2 AP2A1 UBE2J1 MAP3K8 SLC38A1 HARS1 CPNE8 VEZT ACAA2 SRPRB-1 ZEB1 ARF4-1 PWP1 DHX57 ARFIP1 CIAO2A POGLUT3 RARS1 TPM3 FNDC3B G6PD FNDC3A GOLGA7-1 DHX40 IDH1 RAB34 RAI14 ABCF2-H2BE1;ABCF2 SRSF9 TMED10 CBFB MRPL20 COMMD9 SLC38A2 ANPEP ATP6V1C1 ATP6V1F PEDS1-UBE2V1;PEDS1 SLC4A10 TBCA MOV10 NCL-1 HNRNPM WNT5A CHMP2A ANP32B PICALM TRAM1 ADAR MAGT1 MRC2 SPTLC1 SH3BGRL3 TMED7 TMED2-1 ELOVL5 ATRX SIGMAR1 CAPG PRPF40A CSDE1 TCL1A POM121;POM121C PXDN PTMA PNP-1 MTPN SEC23A MRPS33 AKAP8 DNAJB1 POLR2C PPP1R7 SH3BP4 PDLIM7 MPZL1 SLC12A2 GALNT7 TXNRD1 GALNT1 AP3D1 ARCN1 TMEM59 SPCS3 FMNL2 ATP6V0E2;ATP6V0E1 GYS1 NEDD4 PDCD4 LAMTOR5 PLXND1 BET1 FXR2 COL4A2 NCOA3 EGFR E2F3 PRKCI SLC12A4 ARL10 NOTCH2 NOTCH1 TYMS LAMC2 LAMC1 DNMT3B TRIP13 MTHFD2 SMAD1 CXCL12 PANX1 RAB5C BCL6 CPOX PPP2R5C CDKN2A MAT2A MAPK7 MAPK14 MAPK12 CTNNB1 RB1 PKN2 CDKN1A CSNK1D CDKN1B CLOCK SMC1A SLC25A22 SLC25A13 SUCLG2 ARHGDIA TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A E2F1 IQGAP3 CDK6 IRS1 MYLIP FBXW11 DDX5 RAD23B TDG GFPT1 POLD2 USP1 TGFBR2 POLE4 IFRD1 CCN1 GPD2 CAP1 PHC2 HIPK3 CUL4B IGF2R CSRP1 ELMOD2 CDKN1C CEBPB SERPINE2 C1orf56 DCAF7 TERT PRIM1 KCNN4 SAC3D1 HMOX1 ADPGK ATAT1 PTRH1 SYPL1 UNC93B1 HDAC4 POLA2 MYB NELFCD MYCN KRAS NF2 CLDN1 GPAM MET AXL STRN FADS2 FADS1 NT5C3A MYO1E PPP5C NFIA IPO4 CHAF1A LMNB2 LPL RRP8 HOXA5 GTPBP3 OTULINL PKM CEP72 VTI1B FERMT2 HOXD8 VAMP3 TAF9B TRMT1 LY6K MSI2 NPR3-1 ARFIP2 BRI3BP RCOR1 MEOX2 PURA MTX1 YIF1B GEMIN2 ARID2 UTP15 MARS2 RBM19 PTBP1 DHX15 PPP3R1 PTBP2 KIT NT5E PPP3CA TUBA1A BACE1 SRSF10 CDIPT EIF4E TNFSF9 BCL2 CYP1B1 SEC24A PPIF RTN4 RHOB GSTM4 ATP2A2 AGO3;AGO1 SYNE2 SYNE1 TMEM43 GNA13 TPM1 CDKAL1 CYP51A1 BACH1 RAB23 CHORDC1 RAVER2 CDK5RAP1 ANKFY1 SEC62 TRPV6 VPS39 CDK5RAP3 TMEM41B-1 MBNL1 SCAMP1 CARHSP1 METTL7A-1 PDE3A WDR82 KCNQ1 FAR1 HACD3 GRPEL2 ATP6V0A1 SNX6 RAB27B NCEH1 SFXN1 PTPA GFM1 ASH2L PTPRJ PTPRF COIL PISD TMED3 GNL3L-1 GNPNAT1 CTSC MRPS24 RHOG AP3B1 GAK SLC7A6 CDCP1 FRG1 BRPF3-1 SSNA1 AMIGO2 NAPG PGRMC1 SHOC2 SPRYD4 TTC9C WDR11 TPPP3 SNX15 LRRC8A NUCB1 LAMTOR3 TUSC2 LTN1 ARID4B SDCBP LCLAT1 ABHD10 KPNA3 TPM4 TPM2 ATG9A GAS2L1 STX7 ITGA2 UBE4A RAB30 DMTF1 WDFY1 MATR3 GEMIN7 SLC1A4 UAP1 CORO1C SLC9A3R2 RAB6A ANAPC1 CD164 CNOT9 SLC25A1 DOCK5 CALCOCO2 SNAP23 DOCK7 TNFAIP2 CHD1 TMEM109 PLK1 ACP2 SNAP29 SCYL1 HSDL1 ARID1A RCN2 RFT1 RBMS1 LUZP1 YWHAQ NUFIP2 NXN UHRF1 CAND1 TP53INP1 IGF2BP1 ZNF622 PDLIM5 SLC25A24 MYO10 EHMT2 TM6SF1 SLC4A7 EHMT1 SLC25A32 NAA15 DNMT3A EZH2 UBE2S ANXA2 PLAG1 BDNF ADIPOR2 RDH10 NARS1 PPIB ABCG2 MTRR TXN2 C1QBP ATG3 ATAD3A;ATAD3B MCL1 HSD17B12 PGM1 P4HA2 PSAT1 THEM4 AURKB PAFAH1B2 ABHD11 MPDU1 CORI CYCLE%WIKIPATHWAYS_20260910%WP1946%HOMO SAPIENS Cori cycle SLC2A1 SLC2A4 GPT ALDOA LDHA GAPDH-1 PGAM1 PGK1 SLC2A2 HK1 TALDO1 G6PD PFKP INS;INS-IGF2 TPI1 GPI 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260910%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways CYP7A1 EBP EPHX2 DHCR7 ACOX2 ACOT2;ACOT1 SLC27A5 HSD11B1 HSD11B2 SCP2 NPC2 THEM5 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 CYP27A1 DBP AMACR BAAT ACOT6 NPC1-1 SLC27A2 ACOT4 RAS SIGNALING%WIKIPATHWAYS_20260910%WP4223%HOMO SAPIENS Ras signaling RASGRF2 MAPK9 PLA2G5 PLA2G6 JMJD7-PLA2G4B;PLA2G4B RAC3 HTR7 ETS2 ELK1 IKBKB MAPK10 CHUK GAB2 RELA CALML6 CALML3 CALML4 FOXO4 RIN1 PRKACB-1 RASAL1 RASAL2 CDC42 RASAL3 PAK1 TTBK1 BRAP RGL1 PAK3 RGL2 PAK2 RASA4;RASA4B PAK4 KDR PLAAT3 RASSF5 KSR2 RALGDS PLA2G2F RASGRP2 LAT PLA2G2E PDGFRB PLA2G2C RASGRP4 PLD2 RASGRP3 GNB5 GRIN2A ABL1 RALB KIT GRIN2B CALM1 CALM2 RASGRF1 RASA1 PLA2G2A-1 MAPK8 PLA2G4A RAF1 CALM3;CALM1 GRIN1 FLT3 AKT2 AKT3 AKT1 REL PLCE1 PIK3R2 PIK3R1 ZAP70 STK4 NFKB1 MAP2K2;MAP2K1 EPHA2 MAPK1 AFDN RAC1 GNG10 ARF6 MAPK3 NGFR GNG13 PLCG2 NTRK1 BAD ABL2 GAB1 PTPN11 RAB5A GNGT1 IKBKG IGF1R RRAS GRB2 PLD1 SOS1 BCL2L1 RASA2 SHC4 SHC1-1 SHC2 INSR PDGFRA FLT4 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLA2G3 CSF1R SOS2 PLA2G10;LOC100652777 EGFR RAPGEF5 PRKCG PRKCB GNB2 PRKCA GNB1 GNB4 GNB3 RASGRP1 NRAS PLCG1 PLA2G1B PIK3R3 PLA1A HRAS SYNGAP1 NF1 RALBP1-1 RHOA RALA-1 RASA3 EXOC2 KRAS ETS1 BUB1B-PAK6;PAK6 MET GNG2 GNG5 PAK5 FGFR4 GNG4 PRKACA-1 GNG8 FGFR3 TIAM1 FGFR2 RAB5B RAB5C FGFR1 PIK3CD RRAS2 MRAS SHC3 PIK3CB RAP1B RAP1A FASLG TEK KSR1 NTRK2 PIK3CA FLT1 RASSF1 SHOC2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260910%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis DLL1 EPHA4 MESP2 WNT3A FGF8 NOTCH1 HES1 LFNG TBX6 HES7 RIPPLY2 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260910%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL2 IL4 IFNG FAS IL12A IL5 CD86 CD80 CTLA4 VIP TGFB1 CD28 IL10 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP23%HOMO SAPIENS B cell receptor signaling MAP3K7 MAPK9 TEC CD79B CD19 CD79A PLCG2 CD81 PIP5K1A MAPK4 PIP5K1B PRKCD PIP5K1C MAPK14 ATF2 ELK1 GAB1 IKBKB PDPK1 PTPN11 IKBKG CHUK VAV1 GAB2 VAV2 CR2 RAPGEF1 CBL PTPRC RELA GRB2 INPP5D SOS1 CRK LYN SYK BTK NFKBIA SHC1-1 CARD11 BCL10 PTPN6 MALT1 MAX CDC42 MYC CREB1 BLK KLF11 DAPP1 RASGRP3 SH3BP2 PTPN18 GSK3A NFATC3 PRKCB MAPK8 CAMK2A PLCG1 HRAS NFATC2 MAP4K1 RPS6KA1 MAP2K6 FOXO1-1 JUN ETS1 NCK1 CRKL BLNK PIK3AP1 RAF1 CD22 LCK GTF2I FYN AKT1 HCLS1 PIK3CG BCL6 REL GSK3B PIK3R2 BRAF PIK3R1 LAT2 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome ITGB3 ILK SEPTIN2 NFKBIA MYO5A CALCRL CAPN10 ASCL1 TNF TP53 DGKD HDLBP HJURP ERFE KLHL30 PASK THAP4 AGAP1 COPS9-1 ESPNL TRPM8 OR6B2 UBE2F MTERF4 CXCL11 CALM1 STK25 SNED1 RTP5 GMEB1 RNPEPL1 ING5 IL1B LRRFIP1 KIF1A ILKAP PER2 AQP12B DUSP28 OTOS ARL4C SCLY ATG4B USP40 ARF5 DTYMK ASB18 CENPA CYTH2 CYTH4 SPP2 PRLH CYTH1 FARP2 SEPTIN6 MAB21L4 JUN MLPH RAB17 RBM44 ASB1 DISC1 NDUFA10 IL13RA1 GBX2 MAP1LC3A PRL RPS6 ARF1 MYOG RAC1 MEF2A PPP1R7 SH3BP4 PDCD1 CYTH3 AGXT GYS1 D2HGDH RRAGC RAMP1 RRAGA CALCA RRAGB RRAGD ABCA1 PDGFA BOK SEPTIN4-1 GPC1 CFLAR TRAF3IP1 HDAC4 UGT1A1;UGT1A6 NEU4 EGFR MAP1LC3B2;MAP1LC3B-1 HES1 GABARAPL2 HES6 MEF2C SEPTIN12 GABARAP EEF1A1 MAP1LC3C CXCR4 CXCL12 HAMP ACKR3-2 TRAF3 COL6A3 GPR35 RAB27A COPS8 IQCA1 TWIST2 IRF8 MYOD1 ITPK1 PDX1 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260910%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease SMAD2;SMAD3 RUNX2 MAPK3 SERPINE1 MAPK8 MAPK14 NR2C2 CCN2 TGFBR3 ANGPT2 ENG LTBP1 AGTR1 POSTN SMAD4 FBN1 FLNA TGFBR1-1 SHC1-1 FBN2 FBN3 MAPK1 LTBP2 TGFBR2 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260910%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2;SMAD3 POSTN YWHAG SMAD4 SERPINE1 TGFBR1-1 WWTR1 SPARC CCN2 TGFBR3 TGFBR2 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260910%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects MYB KLF2 PRL RGS16 CXCL12 ERBB4 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway MIF AIFM1 PARP1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260910%WP474%HOMO SAPIENS Endochondral ossification NKX3-2 MGP ADAMTS1 CHST11 ALPL PLAT STAT1 PLAU DDR2 CDKN1C IGF1R CAB39 ACAN MMP9 STAT5B SPP1 KIF3A BMP7 FGF2 IHH HDAC4 IFT88 SOX9 SOX6 SOX5 VEGFA MEF2C IGF1 CALM1 RUNX2 COL10A1 IGF2 GHR FRZB PTH1R HMGCS1-1 BMP6 SCIN THRA CTSV;CTSL PTCH1 SLC38A2 FGF18 ADAMTS5 PRKACA-1 MMP13 RUNX3 FGFR3 BMPR1A SERPINH1 FGFR1 TIMP3 COL2A1 AKT1 GLI3 ENPP1 PTH TGFB2 TGFB1 ADAMTS4 PTHLH OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260910%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2J2-1 CYP4F22 CYP19A1 CYP27B1 CYP2C18-1 CYP4X1 CYP7A1 CYP2B6 CYP17A1 CYP2A13;CYP2A6;CYP2A7-1 CYP11A1 CYP2F1 CYP51A1 CYP4B1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP26A1 CYP27C1 CYP2S1 CYP8B1 CYP1A1 CYP2W1 CYP24A1 CYP11B1;CYP11B2 CYP26B1 CYP20A1 CYB5R2 CYP4V2 CYB5R1 CYP2R1 CYB5A CYB5R4 CYP46A1 POR CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP1B1 CYP39A1 CYP7B1 CYP27A1 CYP2U1 CYP2E1 CYB5R3 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5408%HOMO SAPIENS 15q25 copy number variation SH3GL3 RNMT SLC2A1 DNM3 TOP1 BNC1 RYR2 GRM5 AP3D1 GRM1 SPCS3 SPCS1 NMBR RYR1 SHANK1 PDE8A EGF RAF1 RAMAC ZNF592 ADAMTSL3;ADAMTSL1 TENT4B AP3M2 BTBD1 C15orf40 FSD2 SHANK3 WHAMM SEC11A NMB AP3B2 HTT AP3S2;AP3S1 SPCS2 WDR73 ALPK3 HOMER2 SLC28A1 ZSCAN2 ITPR1 TM6SF1 CPEB1 AGAP2 SYNJ1 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260910%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HEY1 VEGFC HES1 VEGFA HIF1A VEGFB HIF1AN DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260910%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development DLL1 PSEN1 REST LATS2 CDKN1B SMARCB1 APP GLI1 CASP9 TFDP1 TFDP2 CASP3 E2F4-1 CCND1 DCAF7 CREB1 FGF2 TP53 APH1A NCSTN GMNN RBL1 HES1 HES5 E2F5 CSNK1A1 DNM1 H3-3A DEPTOR CDK6 CDK4 NOTCH1 PSENEN BACE1 SPRY2 HIP1 SIRT1 MAPT FOXO1-1 EIF2B5 DYRK1A RPTOR NFATC1 TSC2 DNER MLST8 NEUROG2 RBL2 AMPH MTOR TSC1 LIN54 LIN52 GSK3B RAD54L2 LIN37 LIN9 TFAP4 AKT1S1 RBBP4 CRY2 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260910%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K7 MEF2A MAPK3 MAPK7 PRKG1 MAP2K4 MAPK14 IKBKB PDPK1 IKBKG CHUK EGF FGF2 TNF HDAC4 HDAC5 HDAC9 HDAC7 NRG1 IGF1 CDK9 CALM1 MAP3K14 PRKCA PPP3CA PRKD1 PLA2G2A-1 CAMK2D MAPK8 CDK7 NPPA NFATC2 MAP4K1 TNFRSF1A MAP2K7 MAP2K6 MAP2K3 MAP3K1 TGFBR1-1 RAF1 FGFR2 AKT2 AKT1 MTOR MAP2K5 GSK3B LOC118142757;GUCA1A TGFB1 IKBKE MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis SRD5A2 AKR1D1 CYP17A1 HSD3B1;HSD3B2 CYP11A1 CYP21A2 SRD5A1 IL18 SIGNALING%WIKIPATHWAYS_20260910%WP4754%HOMO SAPIENS IL18 signaling TRAF6 MAP3K7 MEF2A MAPK9 MAPK3 PRKAA1 PRKCD IKBKB CTNNB1 CHUK RPS6KB1 IRF1 RELA IL18R1 NFKBIA CASP3 CEBPB IL18 TICAM2 SP1 NCF1 CFLAR PTEN TNF TP53 CYCS-1 IL37 IRAK1 BID GRIN2B NFATC4 PRKCB NOX1 PRKCA MYD88 CASP8 FAS BAX ELAVL1 PARP1 TNFRSF1A MAP2K7 NCF2 ACACB IL18RAP LCK HSPB1 FASLG GSK3B PIK3R1 GATA1 IMP3 CSN2-1 SLC12A3 NFKB1 MAPK1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260910%WP4022%HOMO SAPIENS Pyrimidine metabolism TK1 POLR3B ENTPD3 POLR1A NME3 POLR2C POLR3D CTPS2 POLR1B CTPS1 POLE2 POLR3E DCTD POLR1D NT5M NME6 CMPK1 POLR1E CMPK2 POLE3 UPRT POLR3H DCTPP1 NME4-1 POLR3K RRM1 DUT UCKL1 DHODH NME2 UCK1 POLA1 RRM2-1 PRIM2 PRIM1 RRM2B POLA2 ENPP3 NME7 POLR2A TYMS ENTPD1 DTYMK NME1 POLR1C DCK POLE POLR2D POLR2L DPYS CAD UPB1 POLR1F TYMP NT5C POLR1H POLR3GL TK2 POLD3 POLR3A UMPS POLD4 POLR3C POLR3F DPYD POLR3G POLD1 POLD2 ENPP1 POLR2B POLR2E POLR2G POLR2H POLR2I PNPT1 CDA UPP1 POLE4 POLR2J;POLR2J2;POLR2J3 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260910%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling MYC PDHA1 LDHA TSC2 RXRA IL12A VDR HK3 CD86 AKT1 MTOR PFKFB4 CD80 TSC1 HLA-DRA GSK3B RELA PRKAA2 PIK3CA CYP24A1 IL10 IL2 SIGNALING%WIKIPATHWAYS_20260910%WP49%HOMO SAPIENS IL2 signaling RPS6KB2 IL2RA IL2RB MAPK3 JAK1 STAT1 HRAS STAT3 PTPN11 NMI JAK3 GAB2 MAPT RPS6KB1 CBL GRB2 SOS1 STAT5A STAT5B SYK CRKL SHC1-1 RAF1 LCK IL2 FYN FOXO3 AKT1 IL2RG PTK2B CISH RPS6 PIK3R1 SOCS3 MAP2K2;MAP2K1 MAPK1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260910%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly H4C6 DAXX ATRX H4-16 CHAF1B H2BC15;H2BC3;H2BC11;H2BC12 CHAF1A RBBP4 HIRA SMIM40 H4C1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260910%WP5087%HOMO SAPIENS Pleural mesothelioma PPARGC1A FGF21 ACTG1 RHEB PRKAA2 PRKAG1 PRKAG2 EGF FN1 PRKAG3 AREG FOSL1 CCND1 MYC PRKAB2 PRKAB1 STK38L TNIK SELE PDGFB RPS6KA5 FGF2 ACTB-1 GABPA IL34 MKNK1 MKNK2 MAP3K3 CXCL2;CXCL3;CXCL1-1 IGF1 IL1B MAPK8 MMP3 FZD1 MMP14 LGALS9C;LGALS9;LGALS9B FZD3 MEF2D WNT3A WNT5A WNT7A WNT3 LRP6 AKT2 AKT3 AKT1 MTOR MAP3K6 GSK3B MAP2K2;MAP2K1 EPHA2 MAPK1 MINK1 ADAMTS1 PDGFD MAPK3 DKK1 PDGFC JAK1 NGFR MAP2K4 MAP3K2 STAT1 SOST SLC7A5 IL6 IGF1R RPS6KB1 FRAT2 GRB2 CSNK2A2 SOS1 SFRP4 CSNK2B VEGFB SHC1-1 IL10 VEGFD TCF7 DVL1 DVL2 KITLG FGF20 DVL3 FGF23 FGF22 FGF17 TNNT1 HMGB1-1 SP1 PDGFRA FGF19 FLT4 COL4A2 PTEN COL4A1 COL4A4 FZD10 COL4A6 FGF1 CSF1R AXIN1 CSNK2A1;CSNK2A3 FGF3 FGF4 SLC3A2 FGF5 EFNA4 LEF1 EGFR FGF6 FGF7 FGF8 FGF9 EFNA1 BAK1 EFNA3 EFNA2 FGF14 TCF7L2 TCF7L1 CSNK1A1 WNT5B APC RPS6KB2 FGF13 FGF12 ACTC1;ACTG2 FGF11 KMT2C LIMD1 LAMC3 STK3 SAV1 LAMC2 YAP1-1 LAMC1 TEAD1 MAP4K3 TEAD3 MAP4K4 WNT6 TEAD4 WNT1 MAP4K1 WNT2 MAP4K2 WNT4 NGF MST1 WNT10B LATS1 ACTA1 WNT10A SETD5 FZD2 CXCL12 LAMA5 FZD5 LAMA2 LAMA1 FZD7 LAMA4 LAMA3 FZD6 FZD9 AJUBA FZD8 FGF18 FGFR4 EIF4B SETDB1 FGFR3 ANGPT4 FGFR2 EED LAMB3 FGF10 FGFR1 LAMB2 PDK1 WNT2B LAMB1 PIK3CD PIK3CB PIK3CG TEK CDKN2A NTRK2 WNT16 PIK3CA FLT1 FOXM1 RASSF1 LRP5 PGF MAPK9 WNT11 MAPK7 WDR5 WNT7B MAPK14 BTRC ASXL1 BAP1 MAPK10 MOB1A;MOB1B CTNNB1 LATS2 CDKN1A BRCA1 BBC3 NTF4 FLT3LG OGT-1 CCND3 CCND2 RNF2 MAX CD47 RASSF5 CREB1 CCNE1 TP53 MDM2-2 CYCS-1 SOX17 CER1 SERPINF1 E2F1 SFRP2 SFRP5 CTBP2 PORCN KREMEN1 SENP2 CXXC4 CDK4 CDK2 WIF1 NOTUM BAX ATM CDK7 FOXO1-1 INS;INS-IGF2 FLT3 CCL5 CD274 CCL13;CCL2 TGFB1 NFKB1 CXCL10 CSF3 CSF2 NTRK1 PLAU CCN2 HGF MMP2 MMP9 PDGFA TGFA CCL4L2;CCL4L1;CCL4 TERT CSF1 CASP1 NLRP3 VEGFA MAD2L1 IGF2 HIF1A LIN28B HRAS NF2 MET PAK5 COL4A3 COL4A5 NTF3 CHD8 RING1 HMGN1 RBBP4 CXCL5;CXCL6 PRKAA1 ATF2 ELK1 ATG13 DKK2 KDR DKK4 ULK2 ULK1 PDGFRB ACTA2 BARD1 SFRP1 KIT WWC1 CTBP1 RYK-1 ROR1 ROR2 PLCB4 RPS6KA3 RPS6KA1 MAP3K9 MAP2K7 MAP3K4 MAP2K6 MAP2K3 JUN MAP3K1 DDIT3 BCL2 MAP3K10 RAF1 MAP3K11 YY1 FABP4 MAP3K5 CDH9 AMOT CDH7 ITPR3 CDH5 CDH4 CDH3 AGER CDH20 CDH22 BTC CDH24 CDH10 HBEGF CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 VGLL4 PHC1 TPTEP2-CSNK1E;CSNK1E CDH19 PRSS23 MCU DSC3 BAG2 MDK RASSF2 RASSF3 RB1CC1 RASSF4 TRAF2 RASSF6 BECN1 HCFC1 EFNA5 CTHRC1 BUB1B-PAK6;PAK6 MAP2K5 CDH8 PTK2 ITGB1 ITGB4 ITGB3 ITGB2 ITGAV PODXL ITGA4 KIF23 ITGA3 ITGA2 ITGA1 ITGA6 MAD1L1 SRC PAK1 CUL1 PAK3 PAK2 PAK4 YWHAB UHRF1 IDO1 MAPKAPK2 EZH2 WWTR1 MDM4 BDNF RASSF7 TEAD2 CDH1 CTNNA1 CTNNA3 CTNNA2 TSC2 RPS6 SETD2 EIF4EBP1 ATF3 KDM6A CDH6 CIT CDH2 CDH16 INSR SPARC MCL1 SLC2A1 DEPTOR BMI1 TELO2 CD44 EIF4G1 TTI1 SUZ12 PIGF RPTOR MLST8 ANGPT2 ANGPT1 TSC1 VEGFC NDRG1 AKT1S1 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260910%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression RAF1 EIF4EBP1 MAP3K11 PBK MAPK3 PRKAA1 TSC2 PIK3R3 PIK3CD PIK3CB AKT1 MTOR MAP3K5 TSC1 EIF4E MKNK1 MKNK2 MAP2K6 MAP2K3 PIK3R2 PIK3R1 PIK3CA MAP2K2;MAP2K1 MAPK1 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260910%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 INSR NRIP1 MAPK8 RXRA CREB1 PPARGC1A CEBPD TNF LEP PCK2 IL6 CEBPA IRS1 ADIPOQ IRS2 FOXO1-1 NR3C1 LPIN1 PPARG CEBPB AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260910%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma AGER PINK1 HMGB1-1 STAT3 PRKN TP53 NFE2L2 MDM2-2 KRAS MAP1LC3B2;MAP1LC3B-1 IPO8 TFEB VMP1 SQSTM1 BECN1 MITF NFKB1 SHOC2 ATG7 TFE3 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260910%WP465%HOMO SAPIENS Tryptophan metabolism IL4I1 IDO1 HADH TPH1 ECHS1 STAT1 ACAT1 GCDH ALDH2 CYP1A1 DLD AOC1 TPH2 ALDH8A1 AOX1 AANAT AHR DDC MAOA GOT2-1 AADAT HAAO ASMT ACMSD INMT KMO CAT TDO2 KYNU AFMID KYAT3 KYAT1 IDO2 FANCONI ANEMIA%WIKIPATHWAYS_20260910%WP5465%HOMO SAPIENS Fanconi anemia BRIP1 RAD50 MCM2 FANCI RAD51 ERCC4 MEN1 FANCM FANCL UBE2T FANCA ERCC1 FANCC FANCE PALB2 FANCG SLX4 FANCF ATM ATR MRE11 BRCA1 RFWD3-2 DCLRE1B UHRF2 CTDP1 NBN RAD51C FAAP24 PTEN FANCD2 FAN1 CEBPD BRCA2 SMARCA4 LOC105377022;FANCB XRCC2 USP1 FAAP100 UHRF1 REV1 EGFR HSP90B1 CENPX CENPS-CORT;CORT;CENPS MAD2L2 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members CREBBP MAVS BTRC PARP1 IKBKB EP300 PARP14 IKBKG CHUK SKP1 NFKBIA ZC3HAV1 TIPARP TFPI2 PARP16 CUL1 PARP12 CLDN6 PARP10 ERN1 GSK3B EIF2AK3 RBX1 RELB TBK1 NFKB2 DDX58 MAP3K14 EGF EGFR SIGNALING%WIKIPATHWAYS_20260910%WP437%HOMO SAPIENS EGF EGFR signaling MAPK9 MAPK7 MAPK4 MAPK14 VAV3 ELK1 PDPK1 GAB2 VAV2 FOS GJA1 DOK2 CBL INPP5D CRK STAT5A STAT5B JUND EGF FOXO4 ROCK1 RIN1 SRC CDC42 PAK1 CSK ERBB2 RALGDS CREB1 RPS6KA5 BCAR1 PLD2 AP2A1 AP2M1 ABL1 RALB E2F1 ATXN2 RICTOR MAP3K3 DNM1 RASA1 AP2B1 ELK4 STXBP1 MAPK8 SH3GL2 SPRY2 AP2S1 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K4 FOXO1-1 JUN MAP3K1 RAF1 NDUFA13 MEF2D TNK2 PTK6 INPPL1 AKT1 CBLC MTOR PIAS3 PLCE1 PIK3R2 FOSB PIK3R1 PXDN MAP2K2;MAP2K1 SYNJ1 MAPK1 RAC1 JAK2 EIF4EBP1 CBLB MEF2A NCK2 ARF6 JAK1 MAP3K2 STAT1 PRKCD STAT3 GAB1 PTPN11 RAB5A VAV1 NEDD4 RPS6KB1 LIMK2 GRB2 PLD1 SOS1 GRB10 SHC1-1 ERRFI1 PLSCR1 USP8 USP6NL PEBP1 CFL1 EPS8 STAMBP STAM2 SP1 IQSEC1 SH3KBP1 EPS15 EPS15L1 PTEN ASAP1 REPS2 PTPN12 ITCH NCOA3 ARHGEF1 SOS2 PTK2B IQGAP1 EGFR MEF2C PRKCI EPN1 PRKCB SH3GL3 PRKCA ABI1 PLCG1 CAMK2A PRKCZ HRAS STAM MAP4K1 RALBP1-1 RALA-1 KRAS NCK1 CRKL PTPN5 STMN1 ATF1 NOS3 HGS RAP1A MAP2K5 PIK3C2B PCNA CAV2 PTPRR CAV1 BRAF PTK2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260910%WP4666%HOMO SAPIENS Hepatitis B infection IRF3 MAPK9 DDX3X-1 MAVS MAPK14 ATF2 MAPK12 ELK1 MAPK13 IKBKB MAPK10 EP300 MAPK11 JAK3 CHUK CDKN1A FOS RELA CASP9 STAT5A STAT5B EGR3 CASP3 SRC MYC APAF1 DDB2 VDAC3 CREB1 TNF ATF4 IFNB1-4 YWHAB YWHAQ CYCS-1 IRAK1 BID TAB2 TAB1 MYD88 MAPK8 CASP8 FAS BAX FADD TICAM1 MAP2K7 MAP2K6 MAP2K3 JUN MAP3K1 TGFBR1-1 BCL2 CREB3L2 RAF1 ATP6AP1 DDB1 STAT2 AKT2 AKT3 AKT1 IFNAR1 STAT6 PIK3R2 TGFB2 PIK3R1 TGFB1 YWHAZ TGFB3 IRAK4 NFKB1 MAP2K2;MAP2K1 MAPK1 TGFBR2 JAK2 TRAF6 MAP3K7 MAPK3 JAK1 MAP2K4 CREBBP STAT1 BAD STAT3 TYK2 IKBKG SLC10A1 IL6 CREB3L3 GRB2 CREB3L4 CREB3L1 MMP9 SOS1 CXCL8 ATF6B TICAM2 TIRAP EGR2 TLR4 TLR3 HSPG2 SOS2 PTK2B PRKCG IRF7 NFATC3 NFATC4 PRKCB PRKCA NRAS PIK3R3 HRAS NFATC2 KRAS SMAD4 CREB5 TRAF3 STAT4 SMAD2;SMAD3 ARAF NFATC1 BIRC5 TLR2 PIK3CD PIK3CB FASLG PCNA IFIH1 CREB3 TBK1 BRAF CASP10 PIK3CA IKBKE DDX58 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260910%WP3929%HOMO SAPIENS Chemokine signaling CCR9 ADCY8 WAS VAV3 IKBKB JAK3 CHUK VAV2 CCL27 CCL26 RELA CRK STAT5B XCL1;XCL2 NFKBIA ROCK1 ROCK2 PRKACB-1 CDC42 PAK1 CCR8 CSK CCR6 PF4;PF4V1-1 CX3CR1 GRK2 GNAI3 RASGRP2 GNAI2 CCL1 CXCR6 BCAR1 CXCL13 CCL20 GNB5 CCL25 CCL24 CXCR5 ADCY1 CCL19 CXCL2;CXCL3;CXCL1-1 TIAM2 PARD3 CCL21 CXCL11 WASL PLCB3 PLCB4 CCL17 PLCB1 CCL22 PLCB2 CX3CL1 CCL23;CCL15 RAF1 STAT2 GRK1 CCL5 AKT2 AKT3 AKT1 FGR GRK6 GSK3B PIK3R2 PIK3R1 NFKB1 MAP2K2;MAP2K1 MAPK1 RAC1 CXCL10 JAK2 GNG10 NFKBIB MAPK3 GNG13 GRK5 STAT1 GRK4 PRKCD STAT3 GNGT1 CCR3 CCR2 IKBKG VAV1 ITK ARRB1 ARRB2 HCK GRB2 CCL28 LYN SOS1 CCL3L1;CCL3L3;CCL3;CCL18 ADCY4 SHC4 ADCY2 SHC1-1 SHC2 CCL11 ADCY7 ADCY6 CCL4L2;CCL4L1;CCL4 ADCY5 NCF1 ADCY9 CXCL14 PREX1 ELMO1 CXCL9 DOCK2 SOS2 PRKX PTK2B PPBP PRKCB GNB2 GNB1 GNB4 GNB3 ADCY3 GNAI1 NRAS PIK3R3 CCR10 PRKCZ HRAS PIK3R5 CCR1 XCR1 KRAS CXCR4 CXCL12 CRKL GNG2 GNG5 CCR7 GNG4 GNG8 TIAM1 CCR4 FOXO3 PIK3CD SHC3 PIK3CB PXN RAP1B PIK3CG RAP1A BRAF CXCR3 PTK2 PIK3CA CXCR2 CXCL5;CXCL6 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260910%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling CCK RYR3 RYR2 GNAI1 CCKBR DAGLA GNAQ PLCB1 RYR1 CD38 CNR1 TRPC1 ITPR1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2-2 EPHX2 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260910%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY AKT1 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260910%WP3958%HOMO SAPIENS GPR40 role in insulin secretion FFAR1 GNA11 PLCG2 PLCG1 PKD1 PLCB3 PLCH1 PLCD3 PLCD1 PLCB1 PLCL1 PLCB2 PLCZ1 PLCE1 ITPR3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260910%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells PRKCA RPS6KB2 EIF4EBP1 MAPK9 MAPK3 MAP2K4 MAPK8 PIK3R3 PRKCD MAPK14 MAPK10 EIF4G1 RPS6KA2 RPS6KA1 PDCD4 EIF4A2 MAP2K7 EIF4E RPS6KB1 MAP2K6 MAP2K3 RPTOR EIF4G3 PRKACA-1 EIF4B RPS6KA5 PDK1 AKT2 AKT3 PIK3CB AKT1 MTOR PIK3CG RPS6KA4 CSNK2A1;CSNK2A3 MAP2K5 PIM2 PIK3R2 RPS6 PIK3R1 PIK3CA PIM1 MAP2K2;MAP2K1 MAPK1 EIF4A1 LIPOPROTEIN METABOLISM IN PERIPHERAL TISSUES%WIKIPATHWAYS_20260910%WP5620%HOMO SAPIENS lipoprotein metabolism in peripheral tissues APOC3 LIPC APOC2 APOA1 PLTP CETP APOE APOB LPL LCAT FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP143%HOMO SAPIENS Fatty acid beta oxidation ACADM HADH ACADS LIPC ACSL6 ACSL5 ECHS1 GPD2 ACAT1 GCDH CPT1A CHKB GK PNPLA2 HADHB-1 DLD ACSS2 ACSL3 CPT1B TPI1 CPT2 LIPE ACSL1 CRAT DECR1 ACADVL ECI1 ACSL4 GK2 LIPF HADHA LPL ACADL SLC25A20 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260910%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders FLAD1 RFK PDSS2 COQ6 COQ2 ETFDH APTX ETFA COQ9 COQ7 SLC52A1;SLC52A2 PDSS1 COQ8A TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260910%WP619%HOMO SAPIENS Type II interferon signaling JAK2 CXCL10 IL1B JAK1 REG1B;REG1A STAT1 PRKCD SPI1 ICAM1 PTPN11 ISG15 IRF2 IRF1 NOS2 IFNGR1 STAT2 IFNGR2 IFNG TAP1 CIITA IFNB1-4 OAS1 IRF9 CXCL9 CYBB IRF4 SOCS1 IRF8 PSMB9 EIF2AK2 IFIT2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SOCS3 GBP2;GBP3;GBP1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260910%WP4747%HOMO SAPIENS Netrin UNC5B signaling CDH5 MAPK3 NTN4 ROBO4 NTN3 ALPL COL1A1 MAPK14 ICAM1 CCN2 PTPN11 INPP5D CASP3 IL10 SRC VCAM1 IL1A SELE KDR TNF TP53 ARHGEF12 PTK2B DAPK1-1 RGMA NTN1 UNC5B CIP2A PRKCA RLF PLEKHH1 NEO1 PPP1CA YAP1-1 RHOA DCSTAMP JUN RAF1 PTPA FYN AKT1 CCL13;CCL2 MYF5 PIK3CA PTK2 PPP2R1B MAP2K2;MAP2K1 AGAP2 MAPK1 ITGB4 RAC1 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer EIF4EBP1 NRAS BAD PIK3R3 HRAS CDKN1B RHEB RB1CC1 KRAS FOXO1-1 GRB10 FOXO4 RPTOR ATG13 TSC2 MAPKAP1 NOS3 MLST8 PDK1 ULK1 PTEN FOXO3 PIK3CB AKT1 MTOR PIK3CG GSK3B PIK3R2 RICTOR PIK3R1 PIK3CA TFEB MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260910%WP4318%HOMO SAPIENS Mitochondrial fission and fusion MTFP1 BAX SH3GL2 BNIP3 PHB DNM1L MIB1 MFN1 MFN2 PLD1 BCL2L1 FIS1 OPA1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260910%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome JAK2 C3-1 RABGEF1 CD19 NFATC2IP TUFM ATXN2L SPNS1 CD81 RAB5A NFATC2 VAV2 ATP2A1 CR2 TRAF1 GRB2 TRAF2 IFITM3;IFITM2;IFITM1 INSR IL4 KDR SH2B1 LAT CD82 PRMT1 RABEP2 MPL RAB4A APOPTOSIS%WIKIPATHWAYS_20260910%WP254%HOMO SAPIENS Apoptosis IRF3 NFKBIB PRF1 MAP2K4 BAD CASP5;CASP4 IKBKB MAPK10 IKBKG CHUK IRF2 IGF1R TP63 IRF1 BBC3 RELA CASP9 TRAF2 BCL2L1 NFKBIA CASP3 MYC HRK APAF1 BOK BIRC2 BIRC3 TNFRSF25 DIABLO-1 CFLAR TNF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 BCL2L2 MDM2-2 CYCS-1 CASP7 CASP1 PMAIP1 CASP6 CASP2 IRF7 BAK1 BID MCL1 IGF1 SCAF11 IGF2 CASP8 FAS BAX TRADD XIAP RIPK1 FADD CRADD TNFRSF1A HELLS LTA TRAF1 TNFRSF21 JUN GZMH;GZMB-1 MAP3K1 TRAF3 BCL2 DFFB DFFA NFKBIE TNFRSF1B BIRC5 IRF6 BCL2L11 BNIP3L AKT1 TP73 FASLG IRF4 IRF5 CDKN2A CASP10 PIK3R1 TNFSF10 NFKB1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260910%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IL18 MYD88 SELENBP1 IL1B IL1R1 TLR1 IFNG TIMP1 HBEGF TLR2 F2R TIMP2 ICAM1 CCR3 CCL13;CCL2 PLA2G7 FCER1A IRAK1 F2 NLRP3 MMP9 PIK3CA S100A9 NFKB1 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260910%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 JAK2 PTPN1 NFIB PNCK ERBB3 DLGAP4 ERBB4 TTC9 GJB2 GAL HDGFL2 EIF4G1 CHUK TPM3 CEBPA EIF4E TNFSF11 USF1 NR3C1 STAT5A STAT5B BCL2L1 CEBPB ORAI1 ESR1 ELF5 TFPI2 CCND1 MYC YY1 CLDN6 NFIX TNFRSF11A ERBB2 ESR2 PGR PRL EGFR NFIA CAV1 NFIC PRLR ATP2C2 NRG1 USF2 CSN2-1 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260910%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SLIT2 ROBO4 KDR VEGFA SRC RAC1 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260910%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP1 CALM1 ESR1 SP3 KCNN3 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260910%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 CTNNB1 RB1 CHUK CSNK1D MRE11 RHEB BRCA1 DAG1 CASP9 CDC25B CHEK2 CASP3 ESR1 CHEK1 MAX FOSL1 CDC42 CCND1 PAK1 MYC DHTKD1 RHO CDC25A TFPI PLK1 CREB1 FAU RASGRP3 TP53 MDM2-2 BLM ABL1 BARD1 E2F1 NOXA1 MSH6 BID GSK3A MSH2 ERAL1 UBE2F GADD45A EDAR MYT1 TAB1 JAKMIP1 PML RAD50 RAD51 CDK4 CDK2 CASP8 BAX ATM TRADD CDK7 ATR FADD CERK IRS1 GRN FOXO1-1 JUN TGFBR1-1 BCL2 CDH1 TSC2 SELENOK RAD54L PIAS1 SMARCA4 HIPK2 AKT1 MTOR FOSL2 HDAC1 PIK3R2 AURKA NFKB1 MAP3K13 MAPK1 RAC1 TGFBR2 ZMIZ1 CYP19A1 JAK1 AR STAT1 BAD PKIA MMP1 ANXA1 RRAS NUP85 TPR STK11 SP1 SMAD7 PTEN BRCA2 WEE1 PHB XRCC3 NCOA3 AHR EGFR VEGFA PPP4R3A BAK1 PPP4R3B GDI1 MYCBP2 BACH1 NF1 NAB1 SIRT1 MAP3K7CL ZMYND8-1 RALA-1 ALKBH1 RALGAPA1 CCNB1IP1 SMAD1 PLK3 KRAS SMAD4 FER PIGR USP38 IMPA1 ZNF655 RASGEF1A DCAKD ITPKC USP15 USP16 SMAD2;SMAD3 USP21 FILIP1 ARAF ATF1 BMPR1A BMPR2 HMGCR TSC1 RAP1A RPP38 SMAD6 BRAF ODC1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders CCND1 GALNT3 DMP1 PHEX CYP27B1 FGF23 SLC34A1 SPP1 FAM20C FGFR3 ALPL FGFR2 KL CDKN1A ENPP1 PTH ROS1 CYP24A1 NFKB1 CYP11B1;CYP11B2 ORAI1 NFKB2 MITOPHAGY%WIKIPATHWAYS_20260910%WP5636%HOMO SAPIENS Mitophagy MAPK9 NLRX1 TOMM40 TOMM70 EIF2S1 MAPK10 ATG9A RAB5A ARIH1 SMURF1 MTX1 TRAF2 TOMM20 CSNK2A2 BCL2L1 OPA1 MITF BECN1 SRC BECN2 AMBRA1 CALCOCO2 USP8 RHOT1 SP1 ULK1 RAB7A ATF4 PRKN BNIP3 PHB2 CSNK2A1;CSNK2A3 E2F1 EIF2AK3 MFN1 MFN2 MARCHF5-1 NBR1 ATG9B FKBP8 SQSTM1 RABGEF1 BCL2L13 MAPK8 PINK1 HIF1A VCP-1 KRAS JUN USP15 TFE3 PGAM5 CITED2 FUNDC1 USP30 OPTN-1 MUL1 TAX1BP1 RAB5B RAB7B RAB5C SAMM50 FOXO3 TBC1D17 CCZ1;CCZ1B SIAH1 BNIP3L TBC1D15 HUWE1 TOMM7 MAP1LC3A AMFR TBK1 TFEB FIS1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260910%WP5234%HOMO SAPIENS Bardet Biedl syndrome BBS4 ZIC2 BBS9 CRX LCA5 BBS7 CEP290 CLUAP1 BBS5 RP2 TMEM216 CEP104 ARL3 ARL13B TMEM67 INPP5E PDE6D NPHP3 NEK8 NEK1 BBS2 BBS1 IFT172 MKS1 IFT74 TTC8 CFAP410 MAK EVC2 CEP41 TRAF3IP1 TTC21B GLI2 KIF7 PKHD1 EVC DCDC2 C8orf37 GPR161 WDPCP ARL6 ARNTL BBIP1 INVS USP9X EFHC1 SMO PKD2 TMEM107 MKKS PKD1L1 BBS10 BBS12 CILK1 PCARE RAB23 SCLT1 CNGA1 TRIM32 DYNC2H1 DYNC2I2 LZTFL1 DYNC2I1 CNGB1 PTCH1 IFT140 DYNLT2B WDR19 IFT122 IFT80 WDR35 FUZ DYNC2LI1 IFT43 IFT81 IFT27 PKD1 SCAPER GLI3 IFT52 IFT57 IQCB1 FLCN EFHC2 CEP164 OCRL MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260910%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission JAK2 GABRA1 GABRP AP2B1 GABRA6 GABRA5 GABRA4 NGFR GABRA3 GABRG1 PLCG1 PIK3R3 STAT3 RHOA BDNF SHC1-1 ROCK1 SLC12A5 CREM CREB1 PTEN AP2A1 PIK3CB AP2A2 PIK3CG GABRB3 GABRB2 NTRK2 GABRB1 PIK3R2 PIK3R1 PIK3CA GABRG3;GABRG2 GABRE GABRD GABRQ GABRA2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260910%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system ISG15 EP300 CTNNB1 CDC20 FUS ERG G3BP1 HSPA8 VIM GRK2 ITIH4 PARK7 SHH GSK3A SNCAIP HDAC6 MYD88 TUBA1C PPP1CA MAPK8 BAX CTTN MAPT TUBB3;TUBB6 ACTR1A BDNF NR3C1 EP400 HDAC11 BCL2 RAD23B PROM1 PRDX2 AKT1 MAP3K5 CYBB MAP1LC3A TUBA4A SIRT2 MDH1 GSK3B AURKA KAT5 NDUFV1 MAPK1 RAC1 MAPK3 SGK3;C8orf44-SGK3 MIF TUBA3E;TUBA3C-1 HSF1 TUBB4A;TUBB;TUBB8B;TUBB8 PRDX1 SGK1-1 CSNK2A2 STUB1 CSNK2B APOE VHL ATP13A2 SNCA DCTN1 SOD1 RHOT1 SP1 UBD SMAD7 PRKN HTT HDAC9 PTK2B DNAJA1-1 EGFR BBIP1 SQSTM1 PRKCE APC POU5F1;POU5F1B GRIA1 CFTR HIF1A GRIA2 PRKCZ VCP-1 HSP90AA1 ELP3 DLG2 DLG4 DYNC1I2 MAPRE1-1 SMAD2;SMAD3 TPPP MYH9 FOXP3 BIRC5 OPTN-1 MAP1B PXN KALRN XRCC6 ATXN3 HSPB1 CCDC141 HSPA4 CNOT6 NEDD9 MIIP ELP1 TARDBP ARID3A GARS1 MTHFR DEFICIENCY%WIKIPATHWAYS_20260910%WP4288%HOMO SAPIENS MTHFR deficiency GRIN1 DNMT1 MTHFR COMT HNMT DNMT3A CHKA DNMT3B MARS1 BHMT CYCS-1 GRIN2A NDUFAF7 CHDH PEMT ASMT CASP9 CHPT1 ALDH7A1 GRIN2D PCYT1A EHMT2 CASP3 EHMT1 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260910%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease DGUOK C4orf54 BEND6 DLL4 EFL1 SHCBP1 MAPK3 IBTK ARHGAP31 EOGT NOTCH1 SBDS NOTCH4 KCNN3 NCF2 BTK ESR1 EIF6 CDC42 COX4I2 NOX3 GTF2I SP1 TLR9 TLR8 NCF1 NCF4 CYBA RBPJ CYBB DOCK6 CYBC1 NFKB1 CXXC5 MAPK1 CHCHD2 RAC1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260910%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance JAK2 IL6R EIF4EBP1 NRG2 PDGFD MAPK3 JAK1 PDGFC PLCG2 ERBB3 BAD STAT3 GAB1 PDPK1 HGF IL6 IGF1R RRAS RPS6KB1 GRB2 SOS1 BCL2L1 SHC4 EGF SHC1-1 SHC2 SRC GAS6 PDGFA CCND1 TGFA MYC ERBB2 KDR PDGFRA PDGFB PDGFRB PTEN FGF2 SOS2 EGFR VEGFA PRKCG NRG1 IGF1 PRKCB PRKCA RPS6KB2 NRAS PLCG1 PIK3R3 BAX HRAS NF1 EIF4E KRAS EIF4E2 BCL2 RAF1 MET AXL ARAF FGFR3 FGFR2 FOXO3 PIK3CD AKT2 RRAS2 BCL2L11 AKT3 MRAS PIK3CB AKT1 SHC3 MTOR GSK3B RPS6 PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260910%WP3925%HOMO SAPIENS Amino acid metabolism PC CPS1 SMS EHHADH-1 LDHA SDS HIBADH PKM TPO OTC MCCC1 PPM1L IARS1 VARS1 AOC3 ACAA1-1 CBS;CBSL AUH SRM MMUT ACO2 G6PC2 BCAT1 DLD HIBCH SDHA MARS2 PDHX FH TAT DLST HAL FAH GPT2 PDHA1 ACLY SUCLG1 LARS2 CTH CS MDH2 PNMT DDC MAOA GOT2-1 ALDH7A1 TDO2 EPRS1 GOT1-1 ACADM HADH GLUL GLS TPH1 FTCD MPST PYCR1 HMGCL BHMT RARS1 ADH4 ADH1C;ADH1B;ADH1A GLUD1;GLUD2 ALDH1A1 IDH1 P4HA2 GSS GSR ALDH18A1 PDK4 DBH ADH5 PCK1 HMGCS2 OGDH GCLM FARSB HNMT CAD ACSS1 TH MDH1 HDC ARG2 ASNS OAT ARG1 WARS1 ODC1 ASS1 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260910%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells SLC2A1 LDHA PKM PFKP HK1 PDK1 PDP1 SLC16A1 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260910%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins ATG2B DEPTOR ATG16L1 VPS11 PKM VPS16 VAMP8 TMEM59 ATG9A LAMTOR1 VPS39 RHEB RPS6KB1 RB1CC1 PRKAA2 VPS33A PPP1R9A APOB CALCOCO2 RPTOR EIF4B ATG13 OPTN-1 LARP1-1 TAX1BP1 MLST8 ULK1 RAB7A AKT1 LAMP2 MTOR VPS41 ATG3 MAP1LC3B2;MAP1LC3B-1 GABARAPL2 RPS6 ATG12-1 NBR1 AKT1S1 SQSTM1 ATG4A ATG7 ATG5 VPS18 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260910%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling ILK DEPTOR PPARGC1A IGFBP5 TNFRSF1A IRS1 IGF1R EIF4E RPS6KB1 TNFSF9 ACVR2B PLD1 SMAD2;SMAD3 EIF2B2 RPTOR PRKAB1 NEB MAPKAP1 FBXO32 MLST8 PDK1 PTEN AKT1 MSTN MTOR PIK3CG MAP1LC3A TRIM63 GSK3B RICTOR ITGB1 IGF1 AKT1S1 NFKB1 WASL 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome MTMR8 MTMR9 MAPK3 MTMR6 MEPE MTMR7 CTSB TBX5 SLBP TNKS MCRS1 CSTA PINX1 GATA4 RP1L1 HEPACAM2 CTNNB1 C8orf74 DEFB135 CGAS CLDN23-1 FDFT1 MFHAS1 FAM167A BMP1 XKR6 SLC35G4;SLC35G5;SLC35G3;SLC35G6 SOX7 SLC2A4 RAF1 TERF1-1 TERT NUMA1 PPP1R3B SGPL1 TLR2 BLK ERI1 TLR4 NKX6-1 AXIN1 HSPD1 S100A10 CTSD NEIL2 PDX1 MAPK1 MSRA GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260910%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes GJA1 PTBP2 HCN4 ERG HAND2 KCNE1;KCNE1B HCN2 KCNQ1 IGF1 KCNJ2 HDAC4 SRF EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer DLL1 DLL3 DLL4 WNT11 WNT7B FOXC2 MAPK14 MAPK12 MAPK13 MAPK11 LATS2 CTNNB1 MPP5 JUP CLDN4 CLDN23-1 CLDN5 CLDN3 ITGA5 PDCD6 CDKL2 CLDN9 CLDN8 FN1 CLDN7 PKP1 EIF5A2 CLDN20 PAK1 CLDN22;CLDN24-1 CLDN10 CLDN15 PKP2 CLDN14 CLDN12 CLDN19 ID2-1 STRAP CLDN18 CLDN17 CLDN16 CRB3 TP53 CLDN11 MAPK8 ZEB1 EZH2 TMPRSS4 MAP2K6 MAP2K3 TGFBR1-1 RAF1 CDH1 FZD1 FZD3 MEF2D WNT3A WNT5A MMP15 WNT7A PROX1 WNT3 LRP6 AKT2 AKT3 AKT1 GSK3B CTDSP1 PIK3R2 TGFB2 PIK3R1 TGFB1 OCLN-1 TGFB3 MAP2K2;MAP2K1 MAPK1 TGFBR2 TRAF6 FOXQ1 MAPK3 MAP2K4 NR2C2 FMNL2 DSP CDH2 SNAI1 SNAI2 MMP2 GRB2 MMP9 SOS1 SHC1-1 NRP2 CLDN6 CLDN2 COL4A2 COL4A1 SPARC GDF15 COL4A4 FZD10 COL4A6 RBPJ NUBPL SOS2 VTN WNT5B NOTCH2 NOTCH3 NOTCH1 NOTCH4 HIF1A PIK3R3 HRAS WNT6 WNT1 WNT2 WNT4 JAG2 TJP1 WNT10B WNT10A ID1 KRAS SMAD4 FZD2 CLDN1 JAG1 FZD5 FZD4 FZD7 FZD6 FZD9 SUZ12 SMAD2;SMAD3 FZD8 COL4A3 COL4A5 EED TUSC3 WNT2B PKD1 PIK3CD TWIST2 PIK3CB ZEB2 WNT9B WNT9A WNT16 PIK3CA FOXM1 RBBP4 LRP5 WNT8A WNT8B DLK1 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260910%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway MAPK9 MAPK3 JAK1 RAC3 STAT1 BAD PRKCD STAT3 DUSP6 IKBKB MAPK10 RB1 IKBKG CHUK CDKN1A RPS6KB1 RELA CASP9 PLD1 BCL2L1 EGF CDC42 CCND1 TGFA PAK1 ERBB2 PAK3 PEBP1 PAK2 PAK4 DDB2 RALGDS BRCA2 RIPK4 PLD2 POLK TP53 RALB EGFR E2F1 E2F2 E2F3 VEGFA BAK1 GADD45B GADD45A GADD45G RPS6KB2 CDK6 RAD51 CDK4 MAPK8 PIK3R3 BAX RALBP1-1 RALA-1 KRAS SMAD4 TGFBR1-1 BUB1B-PAK6;PAK6 RAF1 ARHGEF6 SMAD2;SMAD3 ARAF PAK5 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR CDKN2A PIK3R2 TGFB2 BRAF PIK3CA PIK3R1 TGFB1 TGFB3 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 TGFBR2 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260910%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions ITGAL CD19 STK3 SAV1 YAP1-1 MAPK14 TEAD1 WWTR1 TEAD3 MOB1A;MOB1B TEAD4 LATS2 RHOA MST1 LATS1 FYB1 TEAD2 FOXO1-1 FOXO4 CCR7 STK38L FOXP3 RASSF5 FOXO3 FOXO6 KNSTRN-1 YWHAQ RAB13 FERMT3 RAP1A NDRG1 PRDM1 LPL RAC1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260910%WP2806%HOMO SAPIENS Complement system ITGB3 C3-1 CFP CD19 WAS ICAM1 PROS1 FGB ITGA2 FGA C4BPA ARRB2 C3AR1 LOC110384692;C4A;C4B_2;C4B FGG C5AR2 CR2 FCN2;FCN1 APOA1 PLAUR PLG LRP2 MASP2 MASP1 C5 CFB C1QBP CFD C1S SELPLG IBSP CFI SPP1 C5AR1 SELE CD59 SELP C2 GNAI3 GNAI2 C6 F11 C7 ALB C9 CD55 F10 PTX3 C8A CR1L;CR1 VSIG4 CD93 DCN CFH-3 CFHR1;CFHR2 FCER2 APCS VTN FKBP2 CLEC4M;CD209-2 CSNK1A1 PRKCA FPR1 LAMC1 ICAM2 MBL2-1 F13A1 ADIPOQ F12 ADM SERPING1 LAMA5 ELANE KLKB1 CPN1 CD40 ITGA2B GNA15 PRKACA-1 RPS19 TLR2 LAMB1 PRNP THBS1 CRP FCGR3A;FCGR3B CALR-1 TXN SELL BURN WOUND HEALING%WIKIPATHWAYS_20260910%WP5055%HOMO SAPIENS Burn wound healing KLF4 COL1A1 COL1A2 ICAM1 CD3E MMP1 HGF IL6 SNAI2 MMP2 LGALS1 FBN1 MMP9 EGF CASP3 CXCL8 TNC TIMP1 HMGB1-1 PDGFRB TLR4 TNF IFNB1-4 IL15 TP53 DCN SFRP2 HEXD VEGFA KRT222 PECAM1 CXCL2;CXCL3;CXCL1-1 S100A6 SCEL S100A11 S100A9 AMBP NOX4 SLURP1 TPT1 CDK16 MYD88 IL1B BAX LIN28A F13A1 ACTA1 MMP28 CXCR4 CXCL12 ACHE FOXE1 BCL2 SMAD2;SMAD3 CHRNA7;CHRFAM7A FGFR4 FGFR3 FGFR2 SERPINH1 FGFR1 FST BRD4 AKT1 CCL13;CCL2 INHBA TGFB2 CXCR2 TGFB3 NFKB1 KRT6B;KRT6C;KRT6A LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2874%HOMO SAPIENS Liver X receptor pathway SREBF1 NR1H3 CYP2B6 CYP7A1 SCD RXRA FASN ABCG8 ABCG5 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260910%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 ING2 SKIL STK3 MECP2 MERTK PRMT5 TEAD1 TEAD3 NF1 TEAD4 LATS2 LATS1 HDAC1 SIN3A SKI TEAD2 SATB2 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260910%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms AGT ACE2 TMPRSS2 ACE AGTR1 MAS1 REN PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260910%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PI4K2B MTMR2 TPTE;TPTE2 MTMR8 PI4KB PI4K2A MTMR6 MTM1 PLCG2 PIP5K1A PLCG1 PIP5K1B PIP4K2A PIP5K1C PIKFYVE PLCB3 PLCB4 PLCD3 PLCD4 PLCD1 IPMK PLCB1 INPP5E PLCB2 INPP4B INPP5D PI4KA PTEN PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 INPP4A PIP4P1 PLCE1 INPP5K PIP4K2B PIK3CA PIP4K2C SACM1L OCRL FIG4 MTMR1 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome CYFIP1 TUBGCP2 NIPA1 TUBGCP5 NIPA2 FMR1 TUBGCP6 TUBGCP3 TUBGCP4 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260910%WP5390%HOMO SAPIENS Pancreatic cancer subtypes SLC2A1 SPRR3 ST6GALNAC1 SERPINB3;SERPINB4-1 KRT20 CTSE LGALS4 TFF3-1 VSIG2 AGR2 AGR3 FAM3D LYZ-1 SPINK4 CDH17 KRT7 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ANXA10 LEMD1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 KRT17 MYO1A GPR87 PRR15L LY6D TFF1 VGLL1 CLRN3 DHRS9 CTSV;CTSL AREG FAM83A TNS4 FGFBP1 REG4 SPRR1A;SPRR1B ANXA8;ANXA8L1 PLA2G10;LOC100652777 S100A2 SCEL TSPAN8 CST6 KRT15 KRT6B;KRT6C;KRT6A LUPUS PATHOGENESIS%WIKIPATHWAYS_20260910%WP5559%HOMO SAPIENS Lupus pathogenesis PDCD1 LOC102723996;ICOSLG TNFRSF13C CD40LG TLR9 TLR7 TLR4 CD86 ICOS CD274 CD80 TNFSF13B IL6 BCR CD28 CD40 IL17A COCAINE METABOLISM%WIKIPATHWAYS_20260910%WP2826%HOMO SAPIENS Cocaine metabolism CES2 BCHE CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TAR SYNDROME%WIKIPATHWAYS_20260910%WP5362%HOMO SAPIENS TAR syndrome PEX19 MTA1 CCAR2 STAT3 CD247 LAMTOR1 CD3D UBE2I FURIN IFNG SLC22A4 EGFR HJV HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD160 DNM1 TNFRSF14 BCL2L13 HDAC2 CFTR RBCK1 SIRT1 AKAP10 FARP2 CXCR4 ANKRD35 HAMP EIF4A3 SLC22A12 SLK SUMO2 PDZK1 GPR89A;GPR89B PEX11B MET CLCN3 SLC9A3R1 LCK MAGOH;MAGOHB BRF1 PYM1 PDZK1IP1 MITD1 FLT3 POLR3GL ZFHX3 POLR3C POLR3F POLR3G PIAS3 ITGA10 ITGB1 DDIT4 NFKB1 TXN GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260910%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCA PRKCQ PPP3CA PRKD1 NFATC1 PPP3CB PPP3CC PRKD3 PRKCD PRKCZ PLCB3 PKN3 ANGPT2 PKN2 PPP3R1 GNAQ PKN1 PRKD2 PRKCG PRKCI PRKCH RCAN1 PRKCB PRKCE EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260910%WP410%HOMO SAPIENS Exercise induced circadian regulation GSTP1 NCOA4 PER2 UGP2 PER1 G0S2 IDI1 H2BC15;H2BC3;H2BC11;H2BC12 GSTM3 SF3A3 GFRA1 KLF9 PSMA4 NCKAP1 TUBB3;TUBB6 PURA CLDN5 CLOCK HLA-DMA CEBPB PPP2CB;PPP2CA NR1D2 UCP3 HSPA8 PPP1R3C PIGF HERPUD1 EIF4G2 DAZAP2 BTG1 AZIN1-2 STBD1 SUMO3 ERC2 ETV6 RBPMS ZFR MYF6 DNAJA1-1 CBX3-1 ARNTL TOB1 QKI CRY2 TAB2 VAPA CRY1 SUMO1 GLYCINE METABOLISM%WIKIPATHWAYS_20260910%WP1495%HOMO SAPIENS Glycine metabolism MTHFR SHMT1 SHMT2 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260910%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF3 IFNAR2 JAK1 STAT2 STAT1 MAVS TLR3 IFNB1-4 TYK2 IRF9 TICAM1 ACE2 IFNAR1 IFIH1 TBK1 TRAF3 IKBKE DDX58 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260910%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide MYD88 MAP1LC3A TRAF6 IRF3 IFNG TLR9 TLR4 BECN1 TNF NFKB1 IFNB1-4 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260910%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling HK2 MAPK9 LDHA MAPK14 PPARGC1A ELK1 PDPK1 CPT1A CTNNB1 FOS CLDN5 RELA PRKAA2 EGR1 FN1 SRC SIX1 VIM KDR RPS6KA5 PDGFRB TNF IFNB1-4 TP53 MST1R ABL1 ACTA2 CXCL2;CXCL3;CXCL1-1 IL1B MAPK8 ZEB1 PARP1 DUSP4 RPS6KA3 RPS6KA1 ACACA JUN NR4A1 RAF1 CDH1 FZD1 KLK15 AKT1 SLPI MTOR RPS6KA4 CCL13;CCL2 SOCS1 GSK3B RPS6 PIK3R1 TGFB1 OCLN-1 SOCS3 NFKB1 MAP2K2;MAP2K1 MAPK1 CXCL10 MAPK3 CSF3 CSF2 SP7 GAB1 DUSP6 DUSP1 PDCD4 CDH2 IL6 IGF1R SNAI2 RPS6KB1 GRB2 MMP9 SHC1-1 IL10 CXCL8 IBSP PDGFRA COL4A1 PTEN VEGFA PRKCB SLC2A1 PLCG1 MST1 TJP1 WNT10B SMAD1 CLDN1 CRKL NR0B2 SMAD2;SMAD3 SMAD9 SMAD5 FGFR1 ZEB2 HSPB1 NDRG1 PCNA SMAD6 PTK2 FLT1 CXCL5;CXCL6 ITGB1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260910%WP4753%HOMO SAPIENS Nucleotide excision repair CUL4A ERCC3 ERCC4 POLE2 RPA3 ERCC1 POLE3 ERCC2 ERCC8 ERCC6 CUL4B CDK7 MNAT1 CETN2 POLE RFC5 RFC3 RFC4 RFC2 RAD23A ERCC5;BIVM-ERCC5 RAD23B RFC1 DDB1 GTF2H2C;GTF2H2C_2;GTF2H2 DDB2 POLD3 POLD4 CCNH POLD1 POLD2 LIG1 PCNA RBX1 RPA1 GTF2H1 GTF2H3 RPA2 XPA GTF2H4 XPC POLE4 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260910%WP5173%HOMO SAPIENS Disorders of galactose metabolism GBE1 SLC2A2 PYGL GYG2 PGM1 GALT GYS2 GYS1 GALK1 GYG1 AKR1B1 GALE SLC5A1-1 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC42 STAT3 RHOA AMER3 PLEKHB2 MZT2A;MZT2B STMN2 FAM168B CDC27 GPR148 APC ARHGEF4 RAC1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway ALDH3A1 JUNB IL1B CES3 CAP2 AHRR NCOA1 SERPINB2 MYOF BAX IL12B HSP90AA1 CYP1A2 EP300 CDKN1B SLC7A5 CYP1A1 JUN AIP JUND SRC GSTA3;GSTA5;GSTA1;GSTA2 IL2 NQO1 IFNG IL12A TNF POLK CDC37 UGT1A1;UGT1A6 NFE2L2 CYP1B1 IGFBP1 PTGES3-1 AHR EGFR HES1 TGFB1 ARNT IL17B MGST1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260910%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway HSPA6 TUBA3E;TUBA3C-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 TUBB2B;TUBB2A STUB1 PSMD8 PSMD9 PSMD6 TUBAL3 PSMD7 PSMD4 PSMD2 SNCA PSMD3 CUL1 HSPA8 PSMD1 PSMC2-1 PSMD5 CCNE1 PRKN PSMD11 PSMD10 UBE2L6 UBE2J2 UBE2J1 CASP1 GPR37 HSPA9 SEPTIN5 UBE2G1 UBE2G2 FBXW7 SNCAIP UBA1 HSPA2 TUBA1C SIAH2 TUBA1A CASK CASP8 TUBB3;TUBB6 TUBB4B PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SIAH1 TUBB1 TUBA4A HSPA1A;HSPA1B HSPA4 RNF19A PSMD12 HSPA5 PSMD14 HSPA14 PSMD13 HSPA1L HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260910%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 ZEB1 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling DLL1 PSEN1 DLL3 DLL4 MFAP1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 CHUK JAG2 RRAS JAG1 DNER MAML2 MAML1 RBPJ LEF1 HEY1 HES1 DLK2 PSEN2 MFAP2 MAML3 CNTN6 ADAM10 DLK1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260910%WP704%HOMO SAPIENS Methylation pathways TPMT MAT2A PNMT COMT HNMT MAT1A MAT2B INMT NNMT TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260910%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle DLST OGDH SUCLA2 SUCLG2 SUCLG1 IDH2 IDH3A CS MDH2 ACO2 SDHC SDHD DLD SDHA SDHB IDH3G IDH3B FH PDGF PATHWAY%WIKIPATHWAYS_20260910%WP2526%HOMO SAPIENS PDGF pathway RASA1 MAPK3 JAK1 MAP2K4 MAPK8 PLCG1 STAT1 HRAS STAT3 ELK1 PLA2G4A PTPN11 CHUK RHOA VAV1 ARFIP2 VAV2 FOS GRB2 JUN MAP3K1 SOS1 NFKBIA SHC1-1 SRC PDGFA CDC42 RAF1 PAK1 TIAM1 PDGFB PDGFRB PIK3R1 MAP2K2;MAP2K1 NFKB1 MAPK1 SRF WASL RAC1 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids ASAH2 HIF1A AKT1 MTOR TSC1 S1PR1 S1PR3 CERK IGF1R CERS1 SPHK2 PIK3CA PLD1 NFKB1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260910%WP1601%HOMO SAPIENS Fluoropyrimidine activity TK1 SMUG1 CES2 ABCG2 CES1 CYP2A13;CYP2A6;CYP2A7-1 TYMS ERCC2 RRM1 UCK1 DHFR2;DHFR ABCC3 ABCC4 ABCC5 RRM2-1 SLC29A1 GGH MTHFR DPYS UPB1 TYMP UMPS DPYD TDG TP53 XRCC3 PPAT CDA FPGS SLC22A7 UPP1 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway SQLE IDI1 CYP51A1 MVK NSDHL SC5D MSMO1 DHCR7 MVD HMGCR HMGCS1-1 PMVK FDFT1 FDPS LSS HEROIN METABOLISM%WIKIPATHWAYS_20260910%WP2645%HOMO SAPIENS Heroin metabolism CES2 BCHE CES1 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260910%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways ACTR3-1 WNT11 MAP2K4 NEFM NEFH ERBB4 ELK1 CTNNB1 CDKN1A CDKN1B CBL GRB2 SOS1 PFN1 STAT5A SHC1-1 FN1 ROCK2 SRC DVL1 TGFA PAK1 MYLK MYC ERBB2 SOD1 ACTR2 CAMK1 FZD10 AXIN1 EGFR DAAM1 MYL1 APC GRIA1 PFN3 MAPK8 PLCG1 RHOA GPX1 ACTA1 FZD2 JUN FZD5 NCK1 FZD4 FZD7 PPP2CB;PPP2CA NEFL FZD6 FZD9 RAF1 FZD8 FZD1 NOS1 FZD3 AKT1 PIK3CG GSK3B WNT16 PTK2 MAP2K2;MAP2K1 MAPK1 PFN2-1 LAC PHE PATHWAY%WIKIPATHWAYS_20260910%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260910%WP5360%HOMO SAPIENS KCNQ2 related epilepsies PRKCA PRKACA-1 CHRM1 ANK3 PPP3CC P2RY1 PLCG2 SCN1B BACE1 KCNQ2 KCNQ3 STX1A CSNK2A1;CSNK2A3 AGTR1 BDKRB2 PPP1R10 AKAP5 ITPR1 CALM1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5153%HOMO SAPIENS N glycan biosynthesis MGAT4A-1 MAN1A2 GMPPA MAN1A1 ST6GAL1 ST6GAL2 ALG5 DAD1 MAN1B1 GANAB MAN2A2 MAN2A1 MGAT5 MAN1C1 MGAT3 MGAT5B-1 MGAT4C MGAT4D DOLPP1 MGAT4B STT3A DDOST STT3B ALG10;ALG10B B4GALT3 RFT1 RPN2 RPN1 B4GALT2 GPI FUT8 DPM2 MGAT1 DPAGT1 ALG8 ALG9 B4GALT1 ALG6 TUSC3 MPI PMM2 SRD5A3 ALG2 ALG14 ALG3 DOLK MOGS ALG12 ALG1 ALG11 DPM1 GMPPB DPM3 MGAT2 MPDU1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260910%WP4595%HOMO SAPIENS Urea cycle and associated pathways GOT1-1 GPT CPS1 NOS2 ALDH4A1 LDHB GLS2 ASL NAGS NOS1 SLC25A12 SLC25A13 OTC NOS3 PYCR1 MDH2 GLUD1;GLUD2 MDH1 GOT2-1 OAT ARG1 SLC25A15 FH ASS1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260910%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 ADAM17 AVPR1B CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260910%WP536%HOMO SAPIENS Calcium regulation in cardiac cells ITPR2 ADCY8 ATP2B1 GJA1 RYR1 ORAI1 CASQ1 PRKACB-1 PRKAR2B CACNB1 PRKAR2A CACNB3 PRKAR1B PRKAR1A GNAI3 GNAI2 CAMK1 YWHAE GNB5 YWHAB YWHAQ GNAO1 YWHAH ADCY1 SFN GJA4 CALM1 CALM2 RYR3 CACNA1B CHRM1 CACNA1A PLCB3 ATP2B3 ATP2B2 ADRA1A GJB1 RGS1 CALM3;CALM1 RGS2 ANXA6 GRK6 GJA3 YWHAG GJA5 CALR-1 YWHAZ KCNJ5 GJA8 ITPR1 CACNA1D ITPR3 CACNA1C RGS4 RGS5 RGS3 RGS6 RGS7 GNG13 GNA11 GRK5 GRK4 PRKCD CACNA1S PKIB PKIA GNGT1 PKIG GJB6 RGS18 ARRB1 RGS17 GJC2 ATP2A3 ARRB2 ATP2A2 RGS19 RGS14 RGS16 RGS20 GJA9 STIM2 RGS10 GJC1 ADCY4 CHRM4 GJB4 ADCY2 RGS11 CHRM5 GJB3 ADRB1 GJB5 RGS9 ADRA1D GJD2 ADCY7 CASQ2 ADCY6 ATP1A4 CHRM2 KCNB1 ADCY5 ATP1B3-1 SLC8A3 ATP1B1 SLC8A1 ADCY9 PRKCG PRKCH FXYD2;FXYD6-FXYD2 PRKCB GNB2 PRKCE PRKCA GNB1 ADRB2 GNB4 GNB3 ADCY3 PRKCQ CAMK2B PRKD1 RYR2 GNAI1 CAMK2D CAMK2A PRKCZ GJB2 CAMK2G GNAS-1 GNAQ GNAZ ADRA1B GNG2 GNG5 KCNJ3 GNG4 PRKACA-1 GNG8 CAMK4 CHRM3 ATP1B2 FKBP1A ADRB3 CACNA1E NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260910%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC5A6 ALDH3A1 APOA5 SLC5A9 CES3 CES2 EPHA3 SLC5A3 SLC5A5 ANGPTL4 CES5A SLC5A4 RXRA PLTP PRDX6 SLC6A5 SLCO2B1 IP6K3 SLC2A9 PPARGC1A SLC6A7 SLC6A19 SLC6A8 MAFF EP300 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A11 SLC2A10 ABCC5 SLC2A13 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC5A11 SLC5A12 ESR1 SLC5A10 CBR3 TXNRD3 CCND1 MYC NRIP1 PDGFB TNF FKBP5 SPRY1 DNAJC7 IL1B FTL-1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 G6PD BLVRB NR3C1 JUN GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 SLC27A1 GSTA3;GSTA1 ABCG8 GCLC CPT2 ABCG5 ME1 GSTA3;GSTA5;GSTA1;GSTA2 AKAP13 GCLM EPB41L4B GGT1 APOC3 ARL5B SMARCA1 FABP1 PSMC5 RGS2 ENC1 TNS4 SRGN SCD FGFBP1 EDN2 TSC22D3 SERPINB9 NAV3 ADGRF4 CDC42EP3 SCNN1A CYP1B1 PMP2 MFGE8 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 PTGES3-1 SLC26A2 ABHD2 PRRG4 SEC14L1 GPR153 SERTAD2 SULT2A1-4 STOM PPP1R14C CAVIN2 MGST3 PLK2 EPHA2 MGST1 DNAJC15 MGST2 KTN1 S100P CPEB4 DNAJB1 JUNB AGER CYP2B6 NCOA1 HBEGF TXNRD1 GSTM4 STAT3 GSTM3 PRDX1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 KEAP1 SLC7A11 MAFG CYP1A1 SLC7A5 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SRPX2 SLC6A18 IL2 SLC5A8 IFNG SP1 FGF19 IL12A CYP2C9;CYP2C19 POLK UGT1A1;UGT1A6 NCOA3 IGFBP1 SLC5A2 SLC19A2 EGFR SLC6A20 BAAT HES1 ABCB1 ACADM GSTP1 AHRR FGF13 CYP7A1 SLC6A11 HSP90AB1 CYP2A13;CYP2A6;CYP2A7-1 SLC2A2 CBR1-1 ETNK2 VDR HSP90AA1 CYP8B1 GSTA4 SLC5A1-1 TNFAIP3 SLC2A4 THBD PTPA DNER SCP2 AMIGO2 TXN EHHADH-1 LRRC8A PTGR1-1 NCOA6 ACAA1-1 ACOX1 CPT1A PPARD CDKN1B AIP EGR1 JUND SRC CUL1 SMC1A BIRC2 BIRC3 IL11 NCOA2 CCL20 PPARA GADD45B CAP2 NR1H3 CDK4 CDK1 SLC6A9 MYOF BAX ABCC3 SREBF1 ABCC4 ABCC2 IRS2 FOXO1-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FASN SLC27A5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 KAT2B KLK15 SLC5A7 CCL13;CCL2 BHLHE40 TGFB2 TGFB1 ARNT IL17B NFKB2 TGFBR2 ZIC2 ANKRD1 SRXN1 CES1 SERPINA1 SLC2A12 IL12B ABCB4 SLC10A1 HGF NR1I3 SNAI2 CDKN1C NR1I2 APOA1 NR1H4 ABCB11 TGFA PDE4B GCC1 SOD3 HMOX1 SLC6A6 B3GNT5 NFE2L2 SLC39A2 SLC39A1 SLC39A4 AHR SLC39A3 NRG1 SQSTM1 SLC2A1 POU5F1;POU5F1B SERPINB2 ALAS1 ALOX5AP PTGS2-2 ACKR3-2 NR0B2 GPAM PDK4 PCK1 NQO1 CDC37 TGFBR3 HSPA1A;HSPA1B SLC39A9 FTH1 FGD4 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC6A17 SLC6A16 SLC6A15 SLC6A14 APOA2 SLC6A13 PGD OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260910%WP5093%HOMO SAPIENS Opioid receptor pathways RGS4 OPRL1 ADCY8 CACNA1B DNMT3A ALDH9A1 PGM1 GATA4 TUBB4A;TUBB;TUBB8B;TUBB8 JUP ARC RELA BDNF RGS9 HSPA8 NOS2 NEU2 RPLP2 HMOX1 OPRM1 GNAI2 TLR4 TNF PIK3CG GNA12 MBP ADCY1 E2F1 HDAC1 MAP1LC3B2;MAP1LC3B-1 PRKCG SQSTM1 RAC1 PRKCE LUPUS THERAPIES%WIKIPATHWAYS_20260910%WP5560%HOMO SAPIENS Lupus therapies C3-1 MS4A1 IL6R C1QC CD19 IL12B TNFSF13B LOC110384692;C4A;C4B_2;C4B IL6 CD40 IL25 C1QB CD22 IFNG IL23A C2 CD40LG IL12A CD86 CD80 CD38 IL17D CD28 IL17C IL17F IL17B IL17A IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260910%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease JAK2 IL12RB1 CSF2 IFNG IL23A STAT1 STAT3 TLR4 TNF IL12B TYK2 IL22 RORC STAT5A STAT5B IL17F IL17A STAT4 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260910%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED27 TAF8 MED23 TBP TAF2 TAF13 H4C1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260910%WP4565%HOMO SAPIENS Neural crest cell migration in cancer SORT1 KIDINS220 NGFR CDH11 PIK3R4 PIK3R3 STAT3 PIK3R6 PIK3R5 RHOA FOS MMP2 BDNF TRIO JUN MMP9 EPHB6 EPHB1 EPHB3 NGEF MMP8 BUB1B-PAK6;PAK6 PAK1 PAK5 PAK3 PAK2 PAK4 TIAM1 EPHB2 PIK3CD AKT2 AKT3 PIK3CB AKT1 EPHB4 F2RL2 PIK3CG NTRK2 PIK3CA ARF1 RAC1 GDNF SIGNALING%WIKIPATHWAYS_20260910%WP5143%HOMO SAPIENS GDNF signaling FMOD 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome DLL1 MCM2 ARF6 INTS4 C1QTNF12 ISG15 PLCH2 TRAF2 CALML6 LRP4 ESR1 DVL1 DLST HSPA8 INTS11 PANK4 INTS13 INTS14 B3GALT6 INTS10 GDE1 CDK11A;CDK11B TMEM52 NOC2L OR4F21;OR4F16;OR4F29;OR4F3 METTL14 SDF4 CCNL2 PLEKHN1 UBE2J2 SAMD11 MUSK VTN ATAD3A;ATAD3B OR4F5;OR4F17;OR4F4 RBX1 SSU72 VEGFA PEX2 ACAP3 HES5 SCNN1D RER1 GABRD CD160 CPTP PEX5 MXRA8 VWA1 TNFRSF14 PEX12 GNB1 AURKAIP1 PARD6B PERM1 TNFRSF18 MEPCE KLHL17 PUSL1 TAS1R3 HES4 TNFSF18 TNFRSF4 CFAP74 BTLA MIB2 RNF223 ELAVL1 PRKCZ PEX10 MORN1 FNDC10 GRIK2 ANKRD65 INTS9 SLC35E2B KRT17 C1orf159 CUL3 DKK3 TNFSF4 TRAF5 SMAD4 MRPL20 SMAD2;SMAD3 MMP23B IFIT1 AGRN PHKG2 COMMD1 IFIH1 NADK SKI TGFB1 TRIM25 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260910%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP2 SGMS1 DEGS2 ASAH1 CERS3 CERS6 CERK CERS1 SPHK2 SPHK1 SGPL1 SGPP2 PLPP1 SPTLC1 GBA SGMS2 GBA2 UGT8 UGCG KDSR CERS4 SGPP1 DEGS1 CERS2 SMPD1 PLPP3 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260910%WP4191%HOMO SAPIENS Caloric restriction and aging SIRT1 MTOR PRKAB2 NAMPT IGF1 PPARGC1A AKT1 TP53 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260910%WP5300%HOMO SAPIENS TROP2 regulatory signaling JAK2 PRKCA RACK1 CDK4 CDK2 NOTCH1 IGF2 STAT1 PRKCD BAX IGF2R CTNNB1 RB1 TACSTD2 CDKN1B MDK IGF1R ACVRL1 ITGA5 CLDN1 JUN FN1 BCL2 CLDN7 SRC CHEK1 ABCC1 CCND1 CDH1 MMP13 PAK4 VIM PTEN CCNE1 TLN1 EGFR CDKN2A PIK3R1 PTK2 PECAM1 PSEN2 ITGB1 IGF1 NFKB1 RAC1 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260910%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX15 ALOX12 FADS2 PTGS2-2 FADS1 ALOX5 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260910%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling MAP3K7 MAPK9 MAPK3 NFKBIB MAPK8 CASP8 MAPK14 IKBKB RIPK1 FADD CTNNB1 CHUK TRAF5 RELA TRAF1 TRAF2 JUN TRAF3 NFKBIA CASP3 RAF1 BIRC2 BIRC3 TNF AKT2 AKT1 TRIM63 TNFRSF12A GSK3B CASP7 HDAC1 RELB NFKB1 MAPK1 NFKB2 RAC1 MAP3K14 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer APAF1 SERPINE1 DDB2 SESN3 CASP8 BAX PTEN SIAH1 ATM TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 MDM2-2 SHISA5 CYS1 EI24-1 BBC3 PMAIP1 CASP9 BID CHEK2 ZMAT3 CASP3 PERP CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260910%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MAPK9 MAPK3 RAC3 BAD MAPK10 CTNNB1 CDKN1A FOS BBC3 CASP9 CASP3 TCF7 APPL1 CCND1 MYC DDB2 RALGDS POLK APC2 TP53 AXIN1 CYCS-1 AXIN2 DCC LEF1 RALB PMAIP1 MSH6 BAK1 MSH2 NTN1 TCF7L2 GADD45B MSH3 TCF7L1 GADD45A CSNK1A1 GADD45G APC MAPK8 BAX RHOA RALA-1 EXOC2 KRAS PTGS2-2 SMAD4 JUN TGFBR1-1 BCL2 RAF1 SMAD2;SMAD3 ARAF BIRC5 AKT2 BCL2L11 AKT3 AKT1 REL GSK3B TBK1 TGFB2 BRAF TGFB1 TGFB3 MAP2K2;MAP2K1 MLH1 MAPK1 RAC1 TGFBR2 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260910%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification DLL1 LPAR1 DLL3 MGP DLL4 FGFR3 NOTCH1 ALPL PLAT SAT1 ITGA1 JAG2 SOX6 VEGFA JAG1 GJA5 CALU COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP558%HOMO SAPIENS Complement and coagulation cascades C3-1 C1QC SERPINA1 SERPINE1 PLAT PLAU PROS1 CLU FGB SERPINA5 C8G C3AR1 LOC110384692;C4A;C4B_2;C4B CR2 SERPINF2 PLAUR F2 F3 F7 F5 F8 PLG F9 MASP2 MASP1 CFB CFD C1QB CPB2 C1S C1R SERPINC1 CFI C5AR1 TFPI C2 LMAN1 F2R C6 CLTC C7 C9 CD55 F10 SERPIND1 CR1L;CR1 PROC F13B CFH-3 KNG1 VWF F12 SERPING1 KLKB1 THBD BDKRB1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260910%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling PRKCA RPS6KB2 RAF1 EIF4EBP1 MAPK3 PRKACA-1 TSC2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREB1 MAPK14 AKT1 MTOR SGK1-1 RHEB FSHB RPS6KB1 GRK6 RPS6 FOXO1-1 MAPK1 CGA SRC FSHR APPL1 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260910%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260910%WP5133%HOMO SAPIENS Non classical role of vitamin D AGT ACE2 CYP2R1 ACE CYP27B1 AGTR1 AGTR2 REN THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260910%WP4297%HOMO SAPIENS Thiamine metabolic pathways OGDH BCKDHA PDHA1 TKT SLC19A2 BCKDK TPK1 SLC25A19 SLC19A3 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260910%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer EIF4EBP1 DEPTOR MAPK3 NRAS AR TELO2 HRAS PARP1 IRS1 RPS6KB1 KRAS INPP4B GRB2 PRR5L SOS1 PARP2 RAF1 ARAF RPTOR TSC2 MAPKAP1 MLST8 PDK1 PTEN AKT2 AKT3 AKT1 MTOR TSC1 SOS2 RICTOR BRAF PIK3R1 PIK3CA AKT1S1 MAP2K2;MAP2K1 MAPK1 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260910%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GNA14 GNA15 RYR3 GRIA1 GRIA3 GRIA4 CACNA1A GNA11 HOMER3 GRIA2 PDK1 GRM1 PLCB3 ATP2B2 PLCB4 GNAQ PLCB1 PLCB2 PRKCG TRPC3 CA8 ITPR1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260910%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit CD247 CD80 SPN CD27 IL2 CD3D CD28 CD3G BCL2 CD3E CD86 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260910%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer SYTL4 UNC13D SYTL3 RAB27B SYTL2 TBC1D10A EXPH5 MADD RAB27A RPH3A MLPH RPH3AL SYTL1 GCC2 MYRIP SYTL5 NEPHROGENESIS%WIKIPATHWAYS_20260910%WP5052%HOMO SAPIENS Nephrogenesis FGF20 TCF21 NOTCH2 WNT3A GREB1L SIX2 RSPO3 RSPO1 BMP7 FOXD1 OSR1 WNT4 PAX2 WNT9B FGF8 ALDH1A2 JAG1 MEIS1 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260910%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists PPARA SCARB1 NR1I2 CD36 NPC1L1 CYP2C9;CYP2C19 VDR PPARD INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260910%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 BCLAF1 SETX JARID2 MORC3 ELL EED STK38 TRIM35 EZH2 AEBP2 MTF2 EZH1 RBBP7 RBBP4 THRAP3 SUZ12 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260910%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte BMP4 BMP2 PRDM16 PPARGC1A LEP SLC7A10 CEBPA SMAD1 ADIPOQ CEBPB PPARGC1B SMAD9 ZIC1 SMAD5 HSPB7 BMP7 HOXC9 MPZL2 CEBPG EBF3;EBF1 HOXC8 ZNF423 CIDEA PPARG PLAC8 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260910%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2C18-1 PPARA PPARG EPHX2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260910%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PRKCA GRIA1 MAPK3 ADCY8 GNAI1 GRIA3 PPP1CA ACTC1;ACTG2 GRIA4 CAMK2A GRM5 GRIA2 GRM1 PPP1CB PPP1CC GNAS-1 ACTG1 PRKACB-1 GJB1 RAF1 ARAF GRIN1 PPP1R1A PRKACA-1 DRD1 DRD2 CREB1 DRD4 CAMK4 ACTB-1 RAP1B GRIN2A RAP1A ADCY1 PRKCG MAP2K2;MAP2K1 CALM1 MAPK1 PRKCB WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260910%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK9 WNT11 MAPK8 WNT7B MAPK10 WNT6 WNT1 CTNNB1 WNT2 RHOA WNT4 WNT10B WNT10A NPHP3 FZD2 FZD5 FZD4 FZD7 FZD6 DVL1 FZD9 DVL2 FZD8 DVL3 FZD1 FZD3 WNT3A WNT5A WNT7A WNT2B WNT3 LRP6 WNT9B WNT16 LRP5 WNT5B INVS AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260910%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAB2 RPTOR PRKAB1 PRKAA1 TSC2 MLST8 CSN1S1 MTOR EIF4G1 EIF4A2 RPS6KB1 EIF4E EEF2K PRKAA2 PRKAG1 PRKAG2 CSN2-1 CSN3 PRKAG3 EEF2 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260910%WP2361%HOMO SAPIENS Gastric cancer network 1 S100P H3-3A UBE2C NOTCH1 ACTL6A RNF216 CENPF CCNA1 MCM4 CEP192 TOP2A RUVBL1 INO80D KIF15 ESM1 MYBL2 ECT2 TPX2 H4-16 SMOC2 GATD3B;GATD3A NUP107 LIN9 KIF20B AURKA E2F7 APC VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260910%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins PROC NQO1 F2 F7 VKORC1 VKORC1L1 AIFM2 F9 GGCX UBIAD1 F10 PROS1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260910%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy RASGRF1 MYEF2 PPP3R1 TGFB1 STAT3 AKT2 NFKB1 AKT1 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260910%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias UROS PPOX CPOX HMBS ALAD ALAS2 ALAS1 FECH UROD SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260910%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CSF2 IL12B CCR1 CCR3 CCR2 CXCR4 IL18R1 CCL3L1;CCL3L3;CCL3;CCL18 CCL4L2;CCL4L1;CCL4 IL12RB1 IL12RB2 IL2 CCR7 IFNGR1 IL4 CCR5 CCR4 IFNGR2 IFNG CD40LG IL12A IL5 CD4 CXCR3 TGFB2 IL4R TGFB1 CD28 TGFB3 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence HPGD ALOX15 GSTP1 ALOX12 LTC4S PTGS1 CYSLTR1 DPEP1 SERPINE1 ALOX5 LTA4H PTGDS CBR1-1 PTGR2 PTGIS EPHX2 PLA2G4A ALOX15B MAPK11 SIRT1 RB1 ALOXE3 CDKN1A GGT5 ABCC4 PRXL2B ALOX5AP GPX1 ALDH1A1 TBXAS1 PTGS2-2 AKR1B1 HPGDS GGT1 FADS2 FADS1 PTGES2 DPEP2 TP53 ELOVL2 PTGES3-1 SLCO2A1 ELOVL5 DECR1 PTGES PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260910%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE6H PDE10A ADCY8 PRKG1 PDE5A PDE6D PDE6B PDE6A ADCY4 ADCY2 ADCY7 ADCY6 PDE3B PDE4B ADCY5 PDE4A PDE4D-1 PPP1R1B CREB1 ADCY10 ADCY9 GRIN2A PDE1B ADCY1 GRIN2C GRIN2B GRIN2D ADCY3 GRIA1 PDE1A CAMK2A GUCY1B1 PDE7A GUCY1A2 GUCY1A1 PDE8B PDE8A PDE2A PDE4C PDE1C PDE3A GRIN1 CHRNA7;CHRFAM7A PDE7B PRKACA-1 NOS1 DRD1 DRD2 ADORA2A PDE12 PDE9A PDE11A PDE6C TNF ALPHA SIGNALING%WIKIPATHWAYS_20260910%WP231%HOMO SAPIENS TNF alpha signaling MAP3K7 PTPRCAP NSMAF MAPK9 NOXO1 MAPK3 NFKBIB MAP2K4 CREBBP PYGL RFK BAD BTRC IKBKB IKBKG CHUK GRB2 CASP9 SKP1 TRAF2 SOS1 BCL2L1 NFKBIA CASP3 PSMD2 CUL1 APAF1 BIRC2 BIRC3 KSR2 MADD PLK1 DIABLO-1 CFLAR TNF CYBA CSNK2A1;CSNK2A3 TANK RFFL CASP7 MAP3K8 BID MAP3K3 TAB3 TAB2 TAB1 MAP3K14 NOX1 GLUL NRAS MAPK8 OTUD7B CASP8 RIPK3 BAX HRAS PRKCZ TRADD TRAP1 HSP90AA1 RIPK1 FADD SMPD2 MAP4K2 TNFRSF1A MAP2K7 FBXW11 KRAS TRAF1 MAP2K6 MAP2K3 JUN MAP3K1 PPP2CB;PPP2CA TNFAIP3 RAF1 NFKBIE TNFRSF1B CDC37 AKT1 MAP3K5 KSR1 REL TBK1 NFKB1 TXN MAPK1 NFKB2 RAC1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260910%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors COL3A1 COL1A2 LAMB2 LAMC1 COL4A2 ITGB6 COL4A1 ITGA1 THBS1 COL6A2 TNXB SDC2 ITGA11 COL6A1 LAMA4 COL5A1 COL6A3 FN1 COL5A3 ITGB5 THBS2 COL5A2 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260910%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PRKCA PRKCQ MAPK3 KISS1R NRAS CYP11A1 PRKCD HRAS PLCB3 PLCB4 ARRB1 ARRB2 AMH PLCB1 PLCB2 KRAS MMP9 RAF1 STAR KISS1 HSD3B1;HSD3B2 BMP15-1 PDK1 PIK3CD AKT2 PIK3CB AKT1 PIK3CG PRKCG PIK3CA PRKCH MAP2K2;MAP2K1 NFKB1 MAPK1 PRKCB GDF9 PRKCE FSHR FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260910%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling CXCL10 MYD88 ITGB2 TRAF6 CBLB IRF3 PLAT LY96 CD14 IL12B IKBKB FGB IKBKG FGA CHUK TICAM1 RHOA LBP FGG IL6 RELA PLG SYK SRC NOS2 TICAM2 TIRAP RASSF5 TYROBP TLR4 TNF TLR3 IFNB1-4 AKT1 FCER1G CCL13;CCL2 IRAK1 IRAK2 REL PIK3CA CXCL2;CXCL3;CXCL1-1 IRAK4 ITGAM NFKB1