S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 ELOVL2 EHHADH HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD PROTEIN N< I>-GLYCOSYLATION INITIAL PHASE (EUKARYOTIC)%BIOCYC%MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS protein N< i>-glycosylation initial phase (eukaryotic) STT3B DPAGT1 OST4 ALG8 ALG9 RPN2 ALG6 RPN1 ALG5 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 DDOST DPM1 DPM2 DPM3 DAD1 STT3A GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS HYPUSINE BIOSYNTHESIS%BIOCYC%PWY-5905 hypusine biosynthesis DHPS DOHH PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 IMPA1 INPP5F IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK RRM1 DUT RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 RRM2B NME6 NME7 CMPK1 CMPK2 NME2P1 UMPS SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis TM7SF2 NSDHL CYP51A1 MSMO1 HSD17B7 LBR &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSM3 ACSL1 ACSM1 ACSL6 ACSM6 FADS2 ACSL5 ACSL4 ACSM5 ACSL3 ACSM4 ACSBG1 SLC27A2 ACSBG2 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) MVK HMGCS1 GGPS1 IDI2 ACAT2 PMVK ACAT1 MVD HMGCR HMGCS2 FDPS IDI1 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 MAOB ALDH2 MAOA TOMT ADH1B COMT ADH6 ALDH3A2 PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II GNPDA1 NAGK GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation FTCD HAL MTHFD1 UROC1 AMDHD1 NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C SACM1L ITPK1 PLCB3 IPMK PLCB4 INPPL1 PIK3CA PTEN PIK3C3 OCRL PLCB1 PLCB2 SYNJ2 ITPKB PI4K2A IPPK INPP5B ITPKC MTMR3 MINPP1 PIK3R4 PIK3R3 INPP5A PIK3R2 SYNJ1 PIK3R1 PIK3R6 PLCG2 INPP5D PIP5K1A ITPKA PIP5K1B INPP5J PIP5K1C PLCG1 INPP5K IP6K1 CDIPT L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I LDHD GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation SOD3 SOD1 CAT SOD2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 COX6A1 MT-ND2 COX7C MT-ND3 MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB6 NDUFB10 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 COX7A2 UQCR11 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis ADSS2 RRM1 GART RRM2 NME2 NME3 NME4 NME5 NME1 RRM2B NME6 NME7 NME2P1 AK1 GMPS AK2 AK3 AK4 AK5 AK7 PFAS AK8 ATIC GUK1 PPAT ADSL PAICS IMPDH1 IMPDH2 ADSS1 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GAD1 GAD2 GLUD1 GLUL GLUD2 ALDH5A1 ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 RRM2B GMPS NME6 NME7 NME2P1 GUK1 IMPDH1 IMPDH2 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME6 DCK NME7 NME2P1 AK5 NME2 NME3 GUK1 NME4 NME5 NME1 DGUOK THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A1 UGT2B11 DIO1 DIO2 UGT1A8 SULT1A2 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP1B1 SULT1A1 CYP2C19 UGT2B11 CYP2A6 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation ADA PNP GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTM4 GGT5 GSTM3 GSTK1 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GSTA5 GSTA4 GSTA3 ANPEP GSTA2 GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT CHONDROITIN SULFATE BIOSYNTHESIS (LATE STAGES)%BIOCYC%PWY-6567 chondroitin sulfate biosynthesis (late stages) CHST13 CHST2 CHST3 CHST7 CHST11 CHST12 UST CHST15 CHST1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II PCYT2 CHKB ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) TM7SF2 KCNH7 DHCR24 LSS SQLE EBP SC5D DHCR7 FDFT1 NSDHL CYP51A1 MSMO1 HSD17B7 LBR PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME6 NME7 CMPK1 CMPK2 NME2P1 NME2 NME3 NME4 NME5 NME1 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PIPOX PYCR1 CRYM DHTKD1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP6V0E1 ATP5PD ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation MTHFD1L FPGS SHMT2 SHMT1 MTHFD1 DIPHTHAMIDE BIOSYNTHESIS%BIOCYC%PWY-6482 diphthamide biosynthesis DPH6 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis KCNH7 DHCR24 LSS SQLE EBP SC5D DHCR7 FDFT1 NSDHL CYP51A1 MSMO1 HSD17B7 LBR TM7SF2 ACAT2 ACAT1 FDPS IDI1 MVK HMGCS1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation UPP2 UPP1 CDA KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis HMGCL BDH2 BDH1 ACAT1 HMGCS2 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH2 ACSS1 ALDH3A2 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCAT2 ECHS1 ACAT2 ACAT1 BCKDHA HADHA DBT BCKDHB BCAT1 DLD ACADSB HSD17B10 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) ELOVL7 FADS1 FADS2 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I UGT1A4 HMOX2 BLVRA HMOX1 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST6GAL1 ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PEDS1 AGPAT1 GNPAT PCYT2 AGPS CHKB FAR1 ETNK2 FAR2 ETNK1 CEPT1 SELENOI PCYT1B PCYT1A CHKA L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR ACYLCERAMIDE BIOSYNTHESIS%BIOCYC%PWY-8042 acylceramide biosynthesis CERS3 CYP4F22 PNPLA1 SLC27A4 L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD TDO2 KYNU AFMID AADAT KYAT3 IDO2 ALDH8A1 IDO1 DHTKD1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B11 HSD17B7 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSM3 ACSL1 ACSM1 ACSL6 ACSM6 FADS2 ELOVL5 ACSL5 ACSL4 ACSM5 ACSL3 ACSM4 ELOVL7 FADS1 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ST3GAL3 FUT2 B3GALT5 ABO FUT3 B3GALT1 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 UBIQUINOL-10 BIOSYNTHESIS%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ3 COQ2 PDSS2 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 NME2P1 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK ITPK1 IPMK GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 PROTEIN N< I>-GLYCOSYLATION PROCESSING PHASE (MAMMALIAN)%BIOCYC%PWY-7919 protein N< i>-glycosylation processing phase (mammalian) MANEA GANAB MAN1A2 PRKCSH MAN1C1 MAN1A1 MOGS MAN1B1 [2FE-2S] IRON-SULFUR CLUSTER BIOSYNTHESIS%BIOCYC%PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis NFS1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 PROTEIN O< I>-MANNOSYLATION II (MAMMALS, CORE M1 AND CORE M2)%BIOCYC%PWY-7922 protein O< i>-mannosylation II (mammals, core M1 and core M2) POMT2 MGAT5B POMT1 DPM1 POMGNT1 DPM2 DPM3 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGS2 PTGDS PTGES PTGS1 HPGDS PTGIS PTGES2 PTGES3 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P1 TPTE2 INPP4A INPP4B INPP5E SACM1L INPPL1 PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 MTMR14 INPP5F INPP5D INPP5J INPP5K PIP4P2 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 HSD17B12 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2A6 ADH1B CYP2E1 CYP4X1 CYP2U1 CYP2S1 DERMATAN SULFATE BIOSYNTHESIS (LATE STAGES)%BIOCYC%PWY-6568 dermatan sulfate biosynthesis (late stages) DSE CHST14 UST CHST15 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 TRNA-URIDINE 2-THIOLATION (CYTOPLASMIC)%BIOCYC%PWY-7888 tRNA-uridine 2-thiolation (cytoplasmic) NFS1 TRMT112 CTU2 CTU1 MOCS3 ALKBH8 MPST PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IP6K2 IPPK PPIP5K1 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD1 TXNRD3 TXNRD2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis OXCT1 BDH2 BDH1 ACAT1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 BIOTIN-CARBOXYL CARRIER PROTEIN ASSEMBLY%BIOCYC%PWY0-1264 biotin-carboxyl carrier protein assembly HLCS ACACB ACACA L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP1B1 SULT1A1 CYP2C19 UGT2B11 CYP2A6 MAOA SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX4 GPX3 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NAMPT NMNAT3 NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis MBOAT2 ABHD5 AGPAT1 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM GPAT4 LPCAT4 LPCAT3 GPAT3 GPAT2 CDS1 AGPAT5 MBOAT7 MBOAT1 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PGK2 ALDOA PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 GAPDH PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC G6PC3 GAPDHS PGK1 ALDOC ALDOB PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH2 AOC3 AOC2 ALDH3A2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 HSD17B12 ELOVL1 TECR ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSM3 ACSL1 ACSM1 ACSL6 ACSM6 FADS2 ELOVL5 ACSL5 ACSL4 ACSM5 ACSL3 HSD17B12 ACSM4 ACSBG1 SLC27A2 ACSBG2 ELOVL7 FADS1 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis ITPK1 IPMK &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle CNDP2 GGT5 GGCT GCLC GSS OPLAH GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I ENTPD1 CANT1 CTPS2 CTPS1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis PYGB HK3 MGAM HKDC1 PGM2 PYGM PYGL GCK PGM1 HK2 HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation HIBCH ECHS1 ABAT BCKDHA HADHA DBT BCKDHB BCAT1 DLD BCAT2 ACAD8 HIBADH ALDH6A1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM2 GCK PGM1 HK2 HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II FAM98B TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage DCK TK2 TK1 CDA TYMS PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK RRM1 DUT RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 RRM2B NME6 NME7 NME2P1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR1 PYCR2 ALDH18A1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA5 GSTA4 GSTA3 GSTA1 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation ADA NT5C3A NT5E PNP GDA NT5C1A NT5C1B NT5C2 IMPDH1 XDH IMPDH2 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT2A MAT1A MAT2B MTAP ADI1 APIP MRI1 KYAT1 ENOPH1 SRM D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A SYNJ1 IMPA1 INPP5F IMPA2 INPP5J BPNT2 INPP5K BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 SMAD4 BMPR2 ZFYVE16 BMPR1B ACVR2B ACVR2A BMPR1A SKI LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis GGT5 DPEP2 DPEP1 GGT3P LTA4H LTC4S ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 SUPERPATHWAY OF CONVERSION OF GLUCOSE TO ACETYL COA AND ENTRY INTO THE TCA CYCLE%BIOCYC%PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ACO2 PFKM PFKP BPGM DLD GPI TPI1 MDH1 MDH2 PGAM1 GAPDH PGAM2 ENO1 ENO2 ENO3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA FH DLST PDHB IDH3B DLAT HK3 IDH3A PDHA2 PDHA1 SDHC HKDC1 PKLR IDH3G SDHD SDHA GCK CS SDHB PFKL HK2 PKM HK1 SUCLA2 OGDH SUCLG2 SUCLG1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB MAOA COMT SULT1A3 ALDH3A2 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis UGT8 GAL3ST1 ST3GAL5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE DECARBOXYLATION TO ACETYL COA%BIOCYC%PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA PDHB DLAT PDHA2 PDHA1 DLD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH2 ALDH3A1 MAOA ALDH3B2 ALDH1B1 SAT2 ALDH3B1 SAT1 ALDH3A2 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKB CKMT2 CKM CKMT1B QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCAT2 HMGCL MCCC2 AUH IVD MCCC1 HMGCLL1 BCKDHA DBT BCKDHB BCAT1 DLD GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 2-OXOGLUTARATE DECARBOXYLATION TO SUCCINYL-COA%BIOCYC%PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA DLST OGDH DLD L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG AGA ASRGL1 GOT1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A1 UGT2B11 ALDH2 MAOA ADH1B SULT1A3 SULT1A2 ADH6 ALDH3A2 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis ADSS2 AK2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde AFMID IDO2 IDO1 HAAO KMO TDO2 KYNU MRNA CAPPING%BIOCYC%PWY-7375-1 mRNA capping RNGTT RNMT CMTR1 CMTR2 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLA2G4A PLA2G10 PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLCZ1 PLAAT2 PLAAT5 PLAAT4 PLCE1 PLA2G1B PLD4 PLCB3 PLA2G3 PLCB4 PLA2G5 PLD6 PLA2G6 PLCB1 PLD1 PLCB2 PLB1 PLD3 PLD2 OC90 PLA2G2F PLA2G4F PLA2G12A PLA2G2D PLCG2 PLA2G2E PLA2G4D PLA2G4E PNPLA8 PLCG1 PLA2G4B PLA2G2A PLA2G4C EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I TM7SF2 KCNH7 DHCR24 LSS SQLE EBP SC5D DHCR7 FDFT1 NSDHL CYP51A1 MSMO1 HSD17B7 LBR OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GCLC GSS GOT1 GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TPI1 ALDOA TKFC SI KHK ALDOC ALDOB PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY pyridoxal 5'-phosphate salvage PDXK PNPO PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS NME1 DCK NME6 NME7 CMPK1 CMPK2 NME2P1 TK2 TK1 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB CEPT1 PCYT1B PCYT1A CHKA CHPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA CYP2A6 ADH1B SULT1A3 ADH6 HAAO KMO ACMSD TDO2 KYNU QPRT AFMID NADSYN1 SULT1A1 UGT2B11 AKR1A1 IDO2 ALDH8A1 IDO1 DHTKD1 TPH2 SULT1A2 TPH1 DDC AANAT ASMT POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 GCDH CYP2C19 ECHS1 ACAT2 ACAT1 ALDH3A2 NMNAT1 NMNAT3 NMNAT2 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACSL1 ACSL6 ACSL5 ACSL4 EHHADH ACSL3 ACSBG1 SLC27A2 ACSBG2 HSD17B4 SCP2 ACOX2 ACOX1 ACAA1 HADH L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine MAOB AKR1A1 ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 CARS1 FARSA TARS1 CARS2 FARSB TRNA-URIDINE 2-THIOLATION (MAMMALIAN MITOCHONDRIA)%BIOCYC%PWY-7889 tRNA-uridine 2-thiolation (mammalian mitochondria) MTO1 NFS1 GTPBP3 MPST TRMU N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage ADSS2 RRM1 APRT RRM2 HPRT1 NME2 NME3 NME4 NME5 NME1 RRM2B NME6 NME7 NME2P1 PNP ADA AK1 GMPS AK2 AK3 AK4 AK5 AK7 AK8 GUK1 ADSL ADK IMPDH1 IMPDH2 ADSS1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC2 SPTLC3 DEGS1 KDSR SPTSSA CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 DCTD TYMS NME1 RRM2B NME6 NME7 NME2P1 &ALPHA;-DYSTROGLYCAN GLYCOSYLATION%BIOCYC%PWY-7981 α-dystroglycan glycosylation LARGE1 LARGE2 FKTN FKRP CRPPA B4GAT1 RXYLT1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME6 NME7 CMPK1 CMPK2 NME2P1 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH SARDH CHDH SHMT2 ALDH7A1 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle ACO2 FH DLST MDH1 MDH2 IDH3B IDH3A SDHC IDH3G SDHD SDHA CS SDHB SUCLA2 OGDH SUCLG2 SUCLG1 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECHS1 ACSL1 ACSL6 ACSL5 ACSL4 ACSL3 ACSBG1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACAA2 ECI1 HADHB ACADL HADH CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC2 SPTLC3 DEGS1 KDSR SPTSSA CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis ST6GAL1 FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) GCDH ECHS1 ACAT2 ACAT1 HAAO KMO ACMSD TDO2 KYNU AFMID IDO2 ALDH8A1 IDO1 DHTKD1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 ALDH1A2 ALDH1A1 RBP4 RDH16 RBP5 RBP1 SDR16C5 GLYCINE CLEAVAGE%BIOCYC%GLYCLEAV-PWY glycine cleavage GLDC AMT DLD ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL3 ST8SIA2 FUT6 FUT5 FUT9 B4GALT2 B4GALT3 B4GALT1 FUT1 ABO FUT3 ST3GAL4 CHST1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME6 NME7 CMPK1 CMPK2 NME2P1 NME2 NME3 NME4 NME5 NME1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation UPP2 UPP1 DPYS DPYD UPB1 CDA THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSM3 ACSL1 ACSM1 ACSL6 ACSM6 FADS2 ELOVL5 ACSL5 ACSL4 ACSM5 ACSL3 ACSM4 FADS1 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT2 B4GALT3 B4GALT1 GCNT2 GCNT3 B3GNT2 L-PHENYLALANINE DEGRADATION%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation PAH QDPR PCBD1 PCBD2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis PFKM PFKP BPGM GPI TPI1 PGAM1 GAPDH PGAM2 ENO1 ENO2 ENO3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 PKLR GCK PFKL HK2 PKM HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY D-mannose degradation MPI MUCIN CORE 1 AND CORE 2 O< I>-GLYCOSYLATION%BIOCYC%PWY-7433 mucin core 1 and core 2 O< i>-glycosylation GALNT7 GALNT6 GALNT5 GALNT4 GALNT3 GALNT2 GALNT1 C1GALT1 B3GNT3 GALNTL6 ST3GAL2 GCNT3 GALNT12 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GCNT1 GALNT17 GALNT10 GCNT4 ST3GAL1 GCNT7 GALNT9 GALNT8 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 IMPDH1 XDH IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYRP1 TYR ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 GCK TREH HK2 HK1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP2 RDH12 DHRS9 RBP4 RBP3 RBP5 RDH11 RDH10 RBP1 RDH5 LRAT RDH8 DHRS3 RLBP1 RPE65 DHRS4 THYROID HORMONE BIOSYNTHESIS%BIOCYC%PWY-6241 thyroid hormone biosynthesis TPO CTSD ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis SRD5A2 SRD5A1 HSD17B3 AKR1C3 CYP17A1 HSD3B2 HSD3B1 PROCOLLAGEN HYDROXYLATION AND GLYCOSYLATION%BIOCYC%PWY-7894 procollagen hydroxylation and glycosylation COLGALT2 CRTAP PGGHG P3H2 PLOD3 P3H1 PLOD2 P3H3 PLOD1 JMJD6 P4HA1 P4HA2 P4HA3 P4HB PPIB COLGALT1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME6 GMPS NME7 NME2P1 NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP2 BCO1 RDH12 CES2 DHRS9 PNLIP RBP4 CES1 RBP5 RDH11 RDH10 RBP1 LRAT RDH8 DHRS3 CES5A CES4A DHRS4 LIPC 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GNPDA1 GCK GNPDA2 HK2 HK1 GPI PROTEIN O< I>-MANNOSYLATION III (MAMMALS, CORE M3)%BIOCYC%PWY-7979 protein O< i>-mannosylation III (mammals, core M3) POMT2 B3GALNT2 POMK POMT1 POMGNT2 DPM1 DPM2 DPM3 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 ACSL5 ACSL4 ACSL3 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ELOVL7 ACOT2 ACOT1 ACOT4 ACOT7 LIPOATE SALVAGE%BIOCYC%PWY0-522 lipoate salvage LIPT1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACER2 ACER1 ACSL1 ASAH1 ASAH2 SPHK2 SPHK1 PTGR1 SGPP2 SGPP1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate ADA PGM2 PNP PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation UPP2 UPP1 TYMP CDA D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PIP4P1 PLCZ1 PLCE1 PLCH1 PIP4K2A PLCH2 PIP4K2C PLCD3 PLCD4 PLCD1 PLCB3 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 AKR1C1 AKR1C3 AKR1C2 AKR1C4 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 GK3P L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III ADA HPRT1 PNP REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX2 SOD3 GPX1 SOD1 GPX3 GPX6 GPX5 GPX8 GPX7 CAT SOD2 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation ADA NT5C3A NT5E PNP NT5C1A NT5C1B NT5C2 XDH ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2A6 ADH1B CYP2E1 AKR1B10 CYP4X1 AKR1B1 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) ITPK1 IPMK INPPL1 OCRL SYNJ2 ITPKB IPPK INPP5B ITPKC INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIP PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 DAGLB PNLIPRP3 PNPLA2 LIPC CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH 2-OXOISOVALERATE DECARBOXYLATION TO ISOBUTANOYL-COA%BIOCYC%PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA BCKDHA DBT BCKDHB DLD GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis NME6 RRM1 NME7 RRM2 NME2P1 NME2 NME3 NME4 NME5 NME1 RRM2B FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB4 TIGAR PFKFB3 PFKFB2 PFKFB1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis NME6 RRM1 NME7 RRM2 NME2P1 NME2 NME3 NME4 NME5 NME1 RRM2B NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde QPRT NADSYN1 NMNAT1 NMNAT3 NMNAT2 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) ELOVL7 FADS2 ELOVL5 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 CDK11A ST8SIA2 ST6GAL2 B4GALT1 GCNT2 GCNT3 ST3GAL4 B3GNT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH2 ACSS1 CYP2E1 ALDH3A2 CYP2G1P TAURINE BIOSYNTHESIS%BIOCYC%PWY-5331 taurine biosynthesis CSAD CDO1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ACSS2 ALDH2 ACSS1 ADH1B ALDH3A2 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA MCEE DBT PCCA BCKDHB PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1L3 GLB1 LCT NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2A6 CYP2G1P UGT1A4 FMO1 UGT2B11 FMO2 FMO3 FMO4 FMO5 AOX1 FMO6P CYP4X1 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE PGM2 GALT GALM PGM1 GALK1 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GCK GFPT2 HK2 GFPT1 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT DHTKD1 ALDH7A1 AASS L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPHS2 PSTK SARS1 SARS2 SEPSECS SEPHS1 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation PHYH ALDH3A2 SLC27A2 HACL1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 IDI2 FDPS IDI1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW3 TYW1 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 PLAAT5 NAPEPLD ENPP2 GDE1 PLA2G1B PLAAT1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis QPRT AFMID NADSYN1 IDO2 IDO1 NMNAT1 NMNAT3 NMNAT2 HAAO KMO TDO2 KYNU LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSL6 ACSL5 ACSL4 ACSL3 ACSBG1 SLC27A2 ACSBG2 COMPLEX N< I>-LINKED GLYCAN BIOSYNTHESIS (VERTEBRATES)%BIOCYC%PWY-7426 complex N< i>-linked glycan biosynthesis (vertebrates) ST3GAL3 ST6GAL1 MGAT4C FUT8 MAN2A2 MAN2A1 MGAT5 MGAT4A MGAT4B MGAT3 MGAT1 MGAT2 B4GALT1 MGAT5B THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DAGLB DDHD1 DAGLA PLCB1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP2A6 CYP2B6 CYP4X1 CYP2U1 CYP2S1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM2 PGM1 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis PTGS2 LTA4H ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis GLUD1 GLUD2 ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201 folate transformations I MTHFD1L ALDH1L1 MTHFD2 SHMT2 MTHFD2L SHMT1 MTHFR MTHFD1 MTHFS ALDH1L2 MTR GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis PMM1 MPI PMM2 GMPPA GMPPB GPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) TM7SF2 KCNH7 DHCR24 LSS SQLE EBP SC5D DHCR7 FDFT1 NSDHL CYP51A1 MSMO1 HSD17B7 LBR UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ARG1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SARDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SUOX SQOR HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation BCKDHA SDSL DBT BCKDHB DLD SDS GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage HPRT1 PNP CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation MAT2A MAT1A MAT2B BCKDHA MCEE DBT BCKDHB PCCA CDO1 PCCB BHMT MMUT DLD BHMT2 MTR SUOX AHCY GOT1 CBS TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway MVK HMGCS1 IDI2 ACAT2 PMVK ACAT1 MVD HMGCR HMGCS2 IDI1 PROTEIN NEDDYLATION%BIOCYC%PWY-7899 protein NEDDylation CUL1 UBA3 DCUN1D1 NAE1 UBE2M RBX1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II ADO PPCS MUCIN CORE 3 AND CORE 4 O< I>-GLYCOSYLATION%BIOCYC%PWY-7435 mucin core 3 and core 4 O< i>-glycosylation GALNT7 GALNT6 GALNT5 GALNT4 GALNT3 GALNT2 GALNT1 GALNTL6 GCNT3 GALNT12 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MBOAT2 ABHD5 AGPAT1 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM GPAT4 LPCAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT5 MBOAT7 MBOAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 ITPK1 IPMK CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW3 TYW1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-6823 molybdenum cofactor biosynthesis NFS1 MOCS2 MOCS3 MOCS1 GPHN MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH1 MDH2 GOT1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DSP DST RPSA PRKCA YWHAZ PIK3CA ITGA6 PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD DKFZp666O0110 ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 hCG_16983 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 CCND1 ZMIZ1 ZMIZ2 PP2150 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 PIAS1 CCNE1 CDC37 PRKD1 IL6ST HTATIP ZNF278 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN MAGEA11 DKFZp686P15142 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 SIN3A DKFZp686G14213 CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 DKFZp434N101 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A RAF1 CCR1%IOB%CCR1 CCR1 CCL14 SRC CCL3L3 PXN RELA CCL15-CCL14 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 MAPK3 CCR1 CCL23 STAT1 DKFZp666O0110 MAPK14 NFKB1 CREB3 ZAP70 CCL26 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 FOXO3A CCL19 MAPK3 DKFZp434N101 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 DKFZp666O0110 STAT3 PTPN11 ESR2 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 DKFZp434N101 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 PIK3R2 PIK3R1 PTTG1IP HEL-S-17 PRKCZ DKFZp686J04131 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 CXNK2 COX2 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM3 CALM2 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 DKFZp686K0257 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA DKFZp686B23205 PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 DKFZp686O0451 DKFZp666O0110 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 DCBLD2 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 PEBP1 OK/KNS-cl.3 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 GRB10 SIRPA hCG_1991735 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A DYRK1B PRPF4B EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 DKFZp686A13234 PTPRE CDK5 PTPRA SP1 CDK2 ALB BCL2 RAB5A EIF4G1 ITGB1 DKFZp434N101 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HNRPA1 HEL-S-1 CCDC50 NCK1 ACTR3 DSP TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 TENC1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 DKFZp451F1115 FAM62A SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 ZDHHC5 ARAF HEL113 CBLC HEL114 KIAA0142 ANTXR1 CRKL DKFZp434G2016 RPS6KA3 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 EIF3S1 LCK TRAF3 CSNK2B TCP1 BTK PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B hCG_16983 NUMA1 FAF1 HEL113 hCG_20684 PARK2 TIAL1 CASP9 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF PTK2B FYN RAF1 CRK RET JUN MAP2K1 MAP2K2 DKFZp666O0110 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH GM-CSF%IOB%GM-CSF GM-CSF DKFZp434N101 GSK3B GSK3A CSF2 CRKL IKBKB HEL-S-164nA RPS6KA2 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 MAPK8 MAPK1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IFNAR1 IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 STAT6 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ STAT6 RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor GRAP IL7R MAD2L1 DKFZp434N101 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 MITF-C INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS5 LYN DKFZp686J1568 STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 LEPTIN%IOB%LEPTIN Leptin DKFZp666O0110 RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF SHC1 DKFZp666O0110 STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 MITF-C PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B hCG_16983 CSF1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 DKFZp586H0919 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A MAGEA1 EP300 CIR1 SKP2 SKP1 DKFZp762E1511 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 NOV MFNG DKFZp434N181 NUMB NOTCH3 HDAC2 NOTCH1 HDAC1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 HEL-S-72p FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 CRK CD44 ENG ROCK1 HDAC1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC DKFZp666O0110 MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 DKFZp586H0919 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C PRKCB FOXH1 RUNX2 RBX1 DKFZp762H177 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 DKFZp781N011 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 DKFZp451O0517 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK RAF1 NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 DKFZp666O0110 MAPK14 BMX PAK1 FES MAPK1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MARK2 MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A DKFZp781N011 DKFZp566E044 MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 P8 PTPN11 MAPK14 ZA20D2 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 hCG_16983 TNF-alpha UBE2D2 UBE2D3 hCG_20684 RPL8 DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 FKBP5 NSMAF COPB2 PSMD12 PSMD13 KIAA0287 TNFRSF11A PRKCZ DKFZp686J04131 GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL CBL RELA AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 DKFZp686N0152 TNFRSF10C TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX IRF5 ATM DAP3 H2AX DKFZp686A24188 BEX3 PRKAA1 hCG_16983 PRKDC DIABLO SRC TRADD hCG_20684 TNFRSF11B BCL10 WNT%IOB%WNT Wnt SETDB1 CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 DKFZp586H0919 ARRB2 DKFZp586M1622 STM7 DKFZp434G2016 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ROR1 ROR2 PI4K2A CTBP1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 WNT1 MARK2 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY ZNF42 HDAC1 MAX WT1 SP1 MYC SP3 PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB RAC1 FOXO3A JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 MTOR NFKB1 RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 RBL2 CCNA2 KAT2B KAT2A TFDP1 RBL1 CCNE2 TFDP2 CCNE1 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 E2F5 WASF1 E2F6 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP SERPINE1 BRCA1 YY1 UXT CCND3 TRIM28 EP300 MYBL2 TOPBP1 TK1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY PERP TP53INP1 SPP1 DROSHA BAK1 TIGAR NFYA NR1i1 NFYB GDF15 NFYC ARID3A POU4F1 PML POU4F2 APC RFWD2 CARM1 CCNG1 BAX FAS CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP SERPINE1 EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 CCNK STEAP3 HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TSC2 TAP1 DKK1 PRKAB1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B ZNF385 PLK3 JUN DKFZp686J1569 GADD45A SH2D1A TNFRSF10C LIF TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 DKFZp686A24188 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP6 AIFM2 CASP10 BDKRB2 DGCR8 DUSP5 EDN2 GPX1 PRMT1 MMP2 DDB2 hCG_27697 RNF144B VCAN RRM2B IRF5 HDAC2 PCNA BCL2A1 TYRP1 TAF9 RPS27L HTT PPM1J NLRC4 AFP RCHY1 EGFR PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN RFC3 RFC4 FANCM FANCL RMI1 RFC2 hCG_37731 TREX1 XRCC3 ATM FANCA RPA1 MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD50 FANCD2 BRCA1 UBE2T RAD17 FAN1 CENPS RAD9A ATR TOPBP1 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY PPP3CA PPP3CC CAPNS1 CAPNS2 CALM3 MEF2D CALM2 HDAC1 HDAC2 EP300 PRKCB NFATC2 PRKCA NFATC1 CABIN1 BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 MED1 RXRA LPL EP300 PPARG PPARGC1A CREBBP PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML HEL2 ZFYVE9 DKFZp451O0517 CAMK2A SHC1 PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 SKIL MAP3K7 RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 WWP1 TGFBR1 RPS6KB1 TGFBR2 TGFBR3 FKBP1A MAP3K7IP1 ITCH ZFYVE16 GRB2 BAMBI SOS1 CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY F2 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 FZD7 ACTN1 DKFZp666O0110 PRKCA FGF7B NUDT16L1 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY9 RPS6KA5 GNAL CREB1 PRKCE ADCY3 LPAR4 ADCY1 ADCY8 ADCY6 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY SRC ITGB3 PTPRM PIK3R1 F11R CLDN1 CDC42 RAP1A CTNNA1 ITGAV PIP5K1C hCG_1991735 RAC1 FARP2 VAV2 AFDN RAPGEF1 TLN1 CRK NECTIN3 NECTIN2 NECTIN1 PIK3CA CTNNB1 DKFZp666O0110 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY HEL25 HEL113 CDCA8 NCAPG PEBP1 KLHL13 AURKC SMC4 CENPA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 DKFZp686K18126 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 KIF20A tmp_locus_29 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY CTNND1 CLTC ASAP2 SLC2A4 ADRB2 INS PLD2 EDNRB ITGA4 ITGA2 ITGA1 AVPR2 MAPK8IP3 TSHR DKFZp762K123 ACAP1 DKFZp686P1551 BIN1 EXOC4 AGTR1 ITGA7 ITGA6 EXOC6 CTNNA1 EXOC5 ITGAV EXOC2 PIP5K1C ARF6 VAMP3 EXOC1 IL2RA CTNNB1 ITGB1 KNS2 RALA BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY TGFBR1 TGFBR2 MAP3K7IP1 ZFYVE9 APC SKIL MAP3K7 EP300 MAP2K1 SMAD2 CREBBP MAPK3 SMAD4 TGFB1 PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 LAMC2 LAMC1 RXRB ERBB3 RPS6KB1 YWHAQ PIK3CA ERBB2 HEL-S-1 HRAS RXRG YWHAG GRB2 LAMB3 LAMB2 ITGB1 EGF LAMB1 LAMA1 YWHAZ LAMA3 IL1A PMP22 PRKCA EGFR BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY RUVBL1 CDKN2A PIN1 SKP2 AXIN1 HTATIP KAT2A MAX PML MYC TRRAP PPP2CA TAF9 GSK3B TAF12 FBXW7 ACTL6A PPP2R5A SUPT7L RUVBL2 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 ITSN1 PXN WASL EFNA5 KALRN EFNB2 EFNB1 NRAS PAK1 EFNB3 SRC RRAS MAPK1 SHC1 EPHB2 PIK3R1 EPHB1 EPHB4 CDC42 EPHB3 RAP1A NCK1 TF SYNJ1 KRAS RAC1 MAP2K1 MAPK3 HEL-S-31 CRK PIK3CA HRAS GRB2 DKFZp666O0110 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADRB2 RAP2B PRKAR1B PRKAR1A PTGER1 ADCY1 PRKACG PLCE1 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP EPO CITED2 HEL-S-30 BHLHE41 ADM RORA HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p ADFP TFF3 ENG ABCG2 HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HEL-S-17 HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 DKFZp686O0451 BNIP3 HEL-S-133P DKFZp686P18130 CP GCK VEGFA PFKL COPS5 LEP NCOA1 ID2 JUN SP1 TERT SMAD4 CXCR4 SERPINE1 ABCB1 EP300 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB NFKBIA CSNK2B REL SRC PIK3R1 ARRB2 RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY LYN SELP ACTA1 EPHA4 EPHB1 FYN ITGB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY TGFA ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG BTC NRG3 NRG4 ERBB4 HBEGF EGFR PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY ADCY9 EDNRB GNAL JUN PRKCE ADCY3 MAPK14 ADCY1 ADCY8 ADCY6 SRC MAPK1 CDC42 RAC1 MAP2K1 MAPK3 GNAZ GNAI3 GNAI1 CRK GNA14 MAPK8 GNA15 EDNRA GNA11 KPG_011 PTK2B PRKCH HRAS MAP2K2 EDN1 TRPC6 EDN2 EDN3 FOS GNAO1 SLC9A3 PLCB3 COL3A1 COL1A2 GNAQ PRKCQ RAF1 PLCB1 PLCB2 PRKCB PRKCA BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY NFKB1 HEL-S-64p RELA HEL-75 IL8 TNF-alpha HEL-S-44 GPX1 XDH BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY IL13 IL18 IL16 IL2 IL4 IL3 IL6 IF2F IL5 TXLNA IL9 IL17A IL1A IL8 TNF-alpha IL10 IF1DA1 IFNA1 IL15 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAPK8 NFKB1 JUN ATF1 MAPK14 MAP2K3 IKBKB MAP2K4 NFKBIA MAP4K2 MAP3K1 CHUK CRADD TRADD hCG_20684 TRAF2 TANK DKFZp686J04131 RELA TNFRSF1A RIPK1 TNF-alpha IKBKG MAP2K6 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY TCEB1 CDKN2A VHL HIF1AN COPS5 HIF1A EGLN1 EGLN3 EGLN2 HIF3A RBX1 OS9 ARD1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY F2 GRB7 PLD2 PXN MAPK14 PAK1 MAPK1 SHC1 PIK3R1 AGTR1 FYN RELA NCK1 RAC1 MAPK3 PTPN11 CRK MAPK8 FOXO1 GRB14 NFKB1 DKFZp686H0575 RPS6KB1 ANGPT4 PIK3CA STAT5B ANGPT2 ANGPT1 BMX ELF2 GRB2 FES MMP2 ITGB1 CDKN1A PLG FGF2 TNF-alpha DKFZp666O0110 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 YWHAQ ATM GADD45A CDKN2D PRKDC PLK1 CDKN1A MYT1 WEE1 CDC34 DKFZp686G14213 CHEK2 BRCA1 RPS6KA1 MDM2 EP300 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY IL3 STAT5B HRAS FOS GRB2 SOS1 SHC1 RAF1 CSF2RB IL3RA PTPN6 MAP2K1 MAPK3 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASA4 RASA2 NF1 DKFZp781H1715 RIN1 SOS2 HRAS PRKCE GRB2 SOS1 NRAS RRAS PRKCZ RASGRF1 KRAS DAB2IP PRKCB RASAL1 hCG_22119 PRKCA RASGRP4 RASGRP3 SYNGAP1 PLCE1 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY IL2 MAPK8 STAT5B LCK CSNK2A1 IL2RA JUN SYK IL2RB HRAS FOS GRB2 SOS1 SHC1 RAF1 IL2RG MAP2K1 JAK3 MAPK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY CHRNA1 DOCK7 PIK3R3 PIK3CD JUN PIK3R2 MAPK9 CHRNE NRAS BAD STAT3 RNF41 SRC NFATC4 MAPK1 MAPK10 SHC1 NF2 PIK3R1 CDC42 NRG1 NRG2 KRAS RAC1 MAP2K1 MAPK3 PTPN11 MAPK8 MTOR ERBB3 PIK3CA ERBB2 HRAS MAP2K2 FOS GRB2 SOS1 RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY CCNB1 PRKAG1 CDC2 AKAP8 PPP2CA PRKACG DDX5 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY IL4 CCNA2 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 TNFSF6 LTA JAK3 JAK1 PTPN11 GAB2 IL2 DKFZp686H0575 PIK3CA STAT5B LCK IL2RA IL2RB BCL2 GRB2 SOS1 BCL2L1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY SHF CRK IF2F PIK3CA CSNK2A1 JUN FOS GRB2 SOS1 SHC1 PIK3R1 ITGAV DKFZp434N101 PDGFRA CAV3 SHB RAPGEF1 JAK1 CRKL PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY LRPAP1 VLDLR MAPK8 CBL LRP8 GRIN2B RELN PIK3CA DAB1 CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 PAFAH1B1 ITGB1 CDK5R1 PIK3R1 FYN RAP1A GSK3B RAPGEF1 CRKL BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY RPS6KA5 CREB1 MAX MAPK14 MAP2K4 MYC MAP3K1 SHC1 TRADD TRAF2 CDC42 RIPK1 MAP3K7 MAP2K6 RAC1 TGFB1 TGFBR1 HRAS GRB2 ATF2 HSPB2-C11orf52 MKNK1 HMGN1 MAP3K5 HEL-S-102 STAT1 DDIT3 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY MYT1 WEE1 DKFZp686G14213 CDC2 CDK2 ATM CDK4 CHEK1 RB1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY JUN PAK1 STAT3 MAPK1 ACTA1 PIK3R1 RAP1A MAP2K1 MAPK3 RAPGEF1 PTEN CRKL PTPN11 CRK MAPK8 PIK3CA PTK2B HRAS MAP2K2 FOS GRB2 SOS1 ITGB1 RAF1 HGF MAP4K1 DOCK1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY COL4A4 COL4A3 COL4A6 AGTR1 COL4A5 REN AGTR2 ACE2 COL4A2 CMA1 COL4A1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 CDC2 TSG101 CD3G CD3E CD3D UHMK1 MAPK13 HEL-S-89n CD2 CAMK4 RB1CC1 CD247 PRKAR1B PRKAR1A PRKACG PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY LCK MAP3K7IP1 MAPK14 MAP2K3 MAP2K4 PAK1 LYN SRC BLK YES1 RALB DUSP8 FYN DUSP16 CDC42 c-fgr MAPK11 DUSP10 RIPK1 TRAF6 MAP3K12 MAP2K6 RAC1 RALA BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY IL2 MAPK8 IL4 NFKB1 IF2F JUN MAPK14 IKBKB NFKBIA ATF2 MAP3K1 CHUK MAP3K5 TRAF2 RELA TNLG5A TNFRSF9 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY ACTA1 CDC42 WASL WASF1 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 GCK NF1 INS CREB1 SP1 CEBPA CEBPB ACADVL ALAS1 CEBPD SLC2A2 NR3C1 TTR UCP2 NKX2-1 ACADM NR2A1 PCK1 CPT1A IGFBP1 HMGCS1 FOXA1 PKLR FOXF1 ABCC8 PDX1 APOA1 HNF1A CPT1C G6PC1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP DKFZp686O0451 PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 PTPN6 IRS1 IL13RA2 AID MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 STAT6 CCL17 SOCS5 MAPK14 EGR2 HMGA1 SP1 PARP14 COL1A1 CD40LG SELP CCL26 SHC1 PIK3R1 IL2RG BCL6 MYB LTA JAK3 JAK1 CBL MTOR RPS6KB1 PIK3CA GRB2 BCL2L1 COL1A2 IL10 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY CTNND1 ROCK1 FGFR1 GRIA2 DAGLA PIK3R1 LRP5 CDC42 Pe1Fe6 DKFZp686I0746 CDH2 CTNNA1 CNR1 CXNK2 PIP5K1C CAMK2G DKFZp434N101 RAC1 HEL-S-61 PTPN1 JUP GAP43 MYL2 PTPN11 MAPRE1 DAGLB MAPK8 AXIN1 PIK3CA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EPO VHL ASPH P4HB VEGFA COPS5 HIF1A JUN CREB1 EDN1 EP300 HEL-S-133P PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY CRK FLT4 VEGFC VEGFD PIK3CA ITGA4 ITGA2 CREB1 ITGA1 MAPK14 GRB2 SOS1 MAP2K4 ITGB1 COL1A1 COL1A2 MAPK1 SHC1 PIK3R1 RPS6KA1 MAPK11 MAPK3 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CAPNS1 CAPNS2 PPP2CA APP CDK5 GSK3B CDK5R1 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD1 FZD2 FZD5 WNT3A IGFBP4 FZD4 RYK WNT7B ATP6AP2 FZD9 KREMEN1 WNT7A LRP5 FZD8 FZD10 LRP6 WIF1 ROR2 DKK1 RSPO1 WNT1 FZD7 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY ADRBK1 GNAS MAP2K2 HRAS ADCY1 MAPK1 RAF1 PLCB1 c-fgr MAP2K1 KCNA1 MAPK3 KCNA2 KCNA3 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 UBE2L3 PLD2 KLK6 GRK5 SNCA CSNK2A1 SYK TH HEL-117 STUB1 BAD SRC LYN BLK MAPK1 YES1 FYN c-fgr MAPK3 PTK2B LCK FKBP1A PLCB2 PPP2R5D BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NCOA1 NR1i1 MED1 RXRA HDAC1 SMARCE1 PRMT1 SMARCD1 SUPT16H SMARCC1 SMARCC2 ARID1A SMARCA4 CARM1 BAZ1B CHAF1A NCOR1 TSC2 EP300 ACTL6A CREBBP BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY MAPK8 PIK3CA CSNK2A1 JUN HRAS FOS GRB2 SOS1 MAP2K4 STAT3 MAP3K1 SHC1 PIK3R1 RAF1 STAT1 PDGFA DKFZp434N101 PRKCB PDGFRA MAP2K1 PRKCA MAPK3 JAK1 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY SELP IL1A CSF3 IF2F ITGAM SELPLG IL8 SELL TNF-alpha PECAM1 ICAM2 PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY MMP9 ROCK1 IL6 THY1 SRC LYN BLK SELP YES1 CTGF FYN PRKCZ RAP1A c-fgr ITGAM SELPLG PLAT HMGB1 APOB JAM2 TLN1 JAM3 PLAUR MYH2 NFKB1 LCK MMP2 PLG TNF-alpha BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY IGF1 IGF1R IL3 KITLG PIK3CA KIT BCL2 BAD ADCY1 MAPK1 PIK3R1 BAX RPS6KA1 CSF2RB IL3RA PRKAR1B PRKAR1A MAPK3 PRKACG BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY SELE ITGA4 CD44 SELL PECAM1 ITGB1 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 SKP2 CCNA2 CCNE1 SP1 MYC BRCA2 MAP2K1 CREBBP LAMA4 CDKN2A CDC2 CDK2 GSK3A ONECUT1 FOXM1 CENPA FOS CENPB AURKB CKS1B MMP2 CCNB2 RB1 CCND1 PLK1 NEK2 H2BC1 NFATC3 DKFZp686G14213 ETV5 CHEK2 CENPF GAS1 CDK4 EP300 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY CDKN2A PIK3R1 PIK3CA POLR1A POLR1C MDM2 POLR1D TWIST1 TBX2 RAC1 MYC RB1 PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY TBXA2R ADRBK1 PTGDR PTGIR VCAM1 HEL-S-45 ROCK1 RAB11A GNB1 ARHGEF1 GNB5 SYK PRKCE MAPK14 SRC LYN BLK YES1 ARRB2 FYN PRKCZ c-fgr MAPK11 RAC1 GNA14 GNA15 GNA11 SELE LCK PRKCH EGF GNAQ PRKCQ PLCB2 ARR3 PRKCB PIK3R5 GNA13 PRKCA SLC9A3R1 EGFR GNG2 PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PIK3R3 PIK3CD PRL PIK3R2 LRIG1 WWOX CBFA2T3 PRLR ADAM17 DLG4 DKFZp451O0517 NEDD4 MAPK1 SHC1 PIK3R1 FYN NCOR1 NRG1 NRG2 MDM2 EREG BTC NRG3 NRG4 ERBB4 MAPK3 HBEGF WWP1 GRIN2B PIK3CA ERBB2 STAT5B ITCH GRB2 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PIK3CA RPS6KA5 CREB1 HRAS MAPK14 GRB2 SOS1 ADCY1 MAPK1 PIK3R1 RPS6KA1 PRKCB PRKAR1B RAC1 PRKAR1A PRKCA MAPK3 PRKACG PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY RAB11A PLD2 GNB1 LYN IL8RB PPP2R1A ARRB2 VASP ELMO1 PPP2CA DOCK2 c-fgr RAB5A RAB7A GNA14 PDPK1 CBL GNA15 PLCB3 PLCB1 PLCB2 IL8 PRKCB PRKCA GNG2 BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY LRP8 RELN CSNK2A1 CDK5 PAFAH1B1 CDK5R1 DKFZp686I0746 DCTN6 DNAH2 DNAH8 DNAH6 DCTN3 DCX DNCL1 NDEL1 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY EPO EPOR MAPK8 STAT5B CSNK2A1 JUN HRAS FOS GRB2 SOS1 SHC1 RAF1 PTPN6 DKFZp434N101 MAP2K1 MAPK3 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY PSEN1 NRG2 NRG3 PRKCB ERBB4 PRKCA ADAM17 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ITGB3 ACTA1 CAPNS1 EZR CAPNS2 RAC1 ACTN1 ITGB1 TLN1 PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY PIK3R3 WASL PIK3CD JUN PIK3R2 MAPK9 MAP2K4 BAD MAPK10 ARRB2 PIK3R1 FYN PRKCZ PARD6A NCK1 DKFZp434N101 RAC1 MAPK8 KIRREL1 PRKCI CD2AP DKFZp686A1195 PIK3CA NPHS1 NPHS2 F2RL2 NCK2 TRPC6 GRB2 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD247 THY1 CD3G CD3E CD3D PTPRC CD2 PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY BIRC3 MAP3K1 CRADD TRADD ACTA1 hCG_20684 BAX TRAF2 PRF1 TNFRSF1A RIPK1 PIDD1 HEL113 CASP6 CASP10 APP BCL2 hCG_16983 NUMA1 SATB1 DIABLO LMNB2 CASP9 CFL2 CASP3 CASP4 ARHGDIB LMNA TFAP2A DFFB DFFA TNF-alpha PARP1 LIMK1 KRT18 MADD DKFZp666O0110 GAS2 CYCS APAF1 BIRC2 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY ARPC1B KIAA0142 ACTR3 ACTR2 PAX6 TIAM1 IQGAP3 WASL HEL-S-15 HEL-S-47e PRKCE HES5 PAK4 MAP2K3 TNK2 MAP2K4 LIMK2 PAK1 BRAF MAP3K1 ARPC4 APC SRC ARPC5 MAPK1 CDC42BPA YES1 BAIAP2 ARPC2 ARPC3 CDC42 CTNNA1 hCG_1991735 MAP2K6 VAV2 RASGRF1 JUN MAPK9 MAPK14 DKFZp686P1551 PIK3R1 PRKCZ PARD6A RAC1 MAPK3 MYL2 MAPK8 CBL MTOR RPS6KB1 PIK3CA HRAS F2RL2 MAP3K11 CTNNB1 ATF2 RAF1 GSK3B LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2B1 VHL VEGFA FLT4 PIK3CA HRAS SHC1 PIK3R1 EIF2B5 HIF1A EIF2B3 EIF2B2 FLT1 EIF1AX EIF2S2 DKFZp434N101 PRKCB ELAVL1 EIF2S1 PRKCA SUI1 EIF2S3 KDR BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 FOXO4 GHR FOXO1 GH1 NFKB1 PIK3CA IKBKB BAD NFKBIA CHUK CASP9 PIK3R1 PPP2CA RELA TNFSF6 IKBKG FOXO3A BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY ACTA1 RAB1A RAB4A RAB11A RAB6C RAB5A RAB3A RAB7A RAB2 RAB9A RAB27A RAB8A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY FSHR FSHB ADCY1 CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY PSEN1 PSENEN SRC SDC3 CASK PTN POMC FYN MC4R APH1B AgRP IL8 CSPG3 EGFR PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY AURKAIP1 AJUBA KIAA0142 RAN GADD45A NFKBIA PAK1 MDM2 NDEL1 CENPA AURKB AURKA DKFZp686K18126 DKFZp686G14213 BRCA1 PPP2R5D GSK3B HCTP4 OAZ1 FZR1 BIRC5 DLGAP5 TDRD7 CKAP5 TACC3 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY RUVBL1 MMP9 HTATIP KAT2A BAX E2F3 EIF2S1 CREBBP NBN HEL-S-17 NCL BIRC5 DKFZp686O0451 HEL-S-133P CCNB1 EIF4A1 BMI1 PMAIP1 PEG10 UBTF PIM1 ID2 RCC1 HEL-S-162eP CAD NME2 MAX PTMAP7 BCAT1 HMGA1 MYC SHMT1 RPL11 IREB2 CDCA7 HSPD1 MTDH PRDX3 MDIG CCND2 MYCT1 PDCD10 TERT EIF4E HSPA4 HUWE1 KIR3DL1 FOSL1 LIN28B SMAD4 GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 CDK4 EP300 TAF12 ACTL6A TK1 SUPT7L RUVBL2 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY IL6 ERBB3 GRIP1 PIK3CA ERBB2 IL6ST IL6R HRAS GRB2 SOS1 STAT3 CARM1 MAPK1 SHC1 PIK3R1 RAF1 EP300 MAP2K1 ERBB4 MAPK3 EGFR BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNB1 DKFZp686G14213 CDC2 CDK7 SHH CCNH PTCH1 MNAT1 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY F2 CALM3 AGTR2 CALM2 MAPK14 STAT3 MAPK1 SHC1 FYN DKFZp434N101 MAP2K1 MAPK3 MAPK8 GNA11 PTK2B CDK5 HRAS MAP2K2 GRB2 SOS1 KNG1 RAF1 STAT1 PRKCB PRKCA PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY BIRC3 IKBKB MAP2K3 MAP4K2 ADAM17 MAP3K1 CHUK TRADD TRAF2 PRKCZ RELA TNFRSF1A RIPK1 SMPD1 IKBKG MAP3K7 HEL-S-31 PRKCI NFKB1 MAP3K7IP1 hCG_16983 NRK TNFAIP3 TXN SMPD2 BAG4 MAP3K5 FADD RFFL STAT1 TRAF1 TNFRSF1B CYLD TNF-alpha TNIK SQSTM1 NSMAF MADD BIRC2 PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN YWHAQ HEL-S-1 CREB1 TH MAPK14 YWHAG HEL2 YWHAZ DKFZp686G14213 RAF1 HEL-S-102 TSC2 MAPK11 MAPKAPK3 TCF3 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PPP3CA PPP3CC CALM3 GRIN2B CALM2 PRKAR1B PRKCB PRKAR1A PRKCA PRKACG GRIN1 DLG4 BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD247 THY1 CD3G CD3E CD3D PTPRC CD2 CD8A PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY PRNP SERPINC1 PLA2G2A VEGFA GPC1 SLIT2 TGFBR1 TDGF1 FGFR1 TGFBR2 APP LCK LYN SRC LAMA1 BLK YES1 FYN NRG1 c-fgr FGF2 FLT1 SMAD2 TGFB1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAPK8 NGFR PIK3CA NGF CSNK2A1 DPM2 JUN HRAS FOS GRB2 SOS1 SHC1 PIK3R1 RAF1 DKFZp434N101 MAP2K1 MAPK3 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY CCL11 GNB1 PIK3R3 CXCL9 PIK3CD MAPKAP1 PIK3R2 CXCL13 MAPK14 CXCR3 MAP2K3 NRAS MLST8 RICTOR CXCL10 SRC CXCL11 MAPK1 PF4 PIK3R1 MAPK11 KRAS MAP2K6 MAP2K1 MAPK3 GNAZ GNAI3 GNAI1 PDPK1 MTOR PIK3CA HRAS MAP2K2 GNAO1 RAF1 GNG2 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY NTRK1 SHC1 PIK3R1 PIK3CA NGF DPM2 HRAS DKFZp434N101 PRKCB GRB2 SOS1 PRKCA BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY CHEK2 PLK3 ATM ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PTPN11 PDPK1 CBL VEGFA CD2AP PIK3CA MAPK1 NRP1 PIK3R1 SHC2 VEGFB HIF1A DKFZp686J1169 NCK1 FLT1 DKFZp434N101 PRKCB PRKCA MAPK3 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY PPP3CA PPP3CC NFKB1 CALM3 CALM2 EGR2 NFKBIA MYC MAP3K1 CHUK GNAQ RELA VIPR2 VIP DKFZp434N101 PRKAR1B NFATC2 PRKAR1A NFATC1 PRKACG PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY PIM1 SYK IKBKB NRAS STAT3 LYN MAPK1 SHC1 PIK3R1 CSF2 KRAS CSF2RA CCL2 MAP2K1 CISH MAPK3 OSM PRKACG IRF8 PTPN11 GAB2 PIK3CA STAT5B HRAS MAP2K2 FOS GRB2 SOS1 YWHAZ RAF1 STAT1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY ADRBK1 NR1C1 GNAS AP2M1 PLCB1 KCNA1 ADCY1 KCNA2 KCNA3 AP2A1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY NFKB1 EDNRA ADAM12 AGTR2 EDNRB JUN HRAS EDN1 FOS EGF MYC RELA DKFZp434N101 PRKCB PRKCA EGFR PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY ROCK1 MAPK9 PPARG CAMK2A MAPK10 YES1 ARRB2 PRKCZ CDC42 MAP3K7 RAC1 NLK MAPK8 DKFZp586M1622 DVL1 DVL2 FLNA SETDB1 CSNK1A1 FZD2 MAP3K7IP1 DAAM1 FZD5 ROR2 FZD7 CTHRC1 NFATC2 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY IL18 MAPK8 IF2F CD3G CD3E JUN CD3D TYK2 MAPK14 STAT4 CXCR3 CCR5 IL12RB1 IL18R1 CD247 ETV5 MAP2K6 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY SKP1 CDKN1B UBE2M SKP2 TFDP1 CDK2 CCNE1 RBX1 CKS1B RB1 NEDD8 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY NFKB1 IKBKB NFKBIA CHUK TRADD FADD RELA TNFRSF1B TNFRSF1A RIPK1 TNF-alpha TRAF6 IKBKG EP300 CREBBP PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY ADRB2 PXN TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 NCK1 ARF6 GNA14 GNA15 GNA11 EGF GNAQ MST051 ITGA2B CYTH3 CYTH2 KIF13B HGF LHCGR USP6 ARAP2 IPCEF1 GULP1 EFNA1 ACAP2 EPHA2 EGFR PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY THRA NR1C1 NR1H2 NR1H4 NR1C2 NR1B3 RXRB NCOR2 RPS6KB1 FAM120B NCOA1 NR1i1 RARA MED1 RARB RXRA BCL2 RXRG PPARG TNF-alpha ABCA1 THRB TGFB1 PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY RAN NFKB1 ATM RIPK2 UBE2D3 NOD2 BCL10 IKBKB NFKBIA ERC1 CHUK TNFAIP3 RELA TNFRSF1A CYLD TNF-alpha TRAF6 IKBKG PRKCA BIRC2 PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY JUN IKBKB ERC1 HEL-S-71 IL1RN IRAK1 CHUK TICAM2 IL1R1 PIK3R1 IL1R2 IRAK3 PRKCZ IRAK4 RELA IL1B UBE2V1 MYD88 IKBKG MAP3K7 TRAF6 MAP2K6 MAPK8 PRKCI NFKB1 PIK3CA MAP3K7IP1 IL1A SQSTM1 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY GNAS NR3C1 PIK3R1 CALM3 ADRB2 NFKB1 PIK3CA CALM2 RELA ANXA1 NPPA CORIN PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF1 HEL-S-47e ARHGAP9 VAV2 ARHGAP8 TRIO ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 VAV3 ARHGEF2 FARP1 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 CDKN1B PLEKHG6 ARHGEF18 MYO9B ARHGDIB ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 ARHGEF5 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY EZR ADRB2 PRKAR1B PRKAR1A CFTR ADCY1 SLC9A3R1 PRKACG BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY MAPK1 CDC2 HRAS KHDRBS1 MAPK3 PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY DYNC1H1 NUDC HEL-S-303 DYNLT1 PAFAH1B3 CDK5R2 CSNK2A1 HEL2 CDC42 hCG_1991735 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 RELN DAB1 CDK5 MAP1B PAFAH1B1 CDK5R1 PPP2R5D PLA2G7 KATNA1 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY NFKB1 PIK3CA TFDP1 CDK2 HRAS CCNE1 IKBKB NFKBIA PAK1 RB1 CCND1 CDKN1A CHUK CDKN1B MAPK1 PIK3R1 RAF1 RELA CDK6 CDK4 IKBKG RAC1 MAPK3 PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY MMP9 SPP1 ROCK2 PIP5K1A HEL-S-28 JUN SYK NFKBIA MAP3K1 CHUK ITGB3 MAPK1 PIK3R1 CDC42 DKFZp686J04131 RELA ITGAV RAC1 MAPK3 MAPK8 NFKB1 PIK3CA PTK2B CD44 VAV3 FOS MMP2 PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY CTNND1 AJUBA PIK3CA PIP5K1A CASR FMN1 ZYX CTNNB1 SRC VASP PIK3R1 FYN CTNNA1 DKFZp434N101 RAC1 JUP EGFR PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 STXBP4 RRAD DLX5 DKFZp451O0517 DLX6 TBXT FLJ23306 HELLS GPX2 NRG1 TCF7L1 ADRM1 MDM2 KRT5 POU2F2 BRCA2 RUNX1 AXL FASN KRT14 HES1 RAB38 ADA CEBPD CDKN2A WWP1 BDKRB2 ATM ITCH MRE11A CCNB2 IL1A TP63 GSK3B FBXW7 PPP2R5A BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY CCR1 IFNGR1 IFNGR2 IL2 IL4 CCL4 CCL3 CCR7 IF2F CCR4 IL5 CCR3 CXCR3 CCR5 IL12RB1 IL18R1 CD40LG CXCR4 CSF2 TGFB1 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY IF2F SOCS1 STAT3 MAP3K1 CAMK2A MAPK1 PIK3R1 RAP1A IL1B CAMK2G MAP2K1 CEBPB MAPK3 CREBBP JAK1 RAPGEF1 CRKL PTPN11 IFNGR1 CBL MTOR PIK3CA CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY COL4A4 COL4A3 SPP1 COL4A6 COL4A5 IBSP COL4A2 ALPL ENPP1 COL4A1 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 KNG1 FGA SPON2 CD40LG F10 HEL-S-62p ICAM3 F11R ICAM4 GP1BA HEL-S-78p ITGAM CYR61 FCGR2A PROC ITGAX ICAM2 TGFBI PLAT BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY CDK2 ATM BCL2 GADD45A CCNE1 RB1 CCND1 CDKN1A BAX PCNA MDM2 CDK4 TIMP3 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL4 IL2RG RPS6KB1 IRS1 STAT6 GRB2 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A1 EIF4G1 EIF4E EIF4A2 EIF3A AAG1 BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY DUSP2 DUSP9 MAPK8 DUSP8 MAPK14 MAPK3 DUSP4 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY MAPK8 NFKB1 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 FOS IRF9 IFNAR1 FLJ23306 RELA TRAF6 FOSL1 IF1DA1 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL13 IL4 IL3 IF2F IL5 CD40 CD2 CD5 CD7 TLR7 CD33 CSF2 ITGAX IL10 IF1DA1 IFNA1 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY CNGB3 GNB3 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H DKFZp686E1183 GUCA1C GUCY2F RPE65 GRK1 GNGT2 RDH12 ARR3 GNAT2 RGS9BP GRK7 PDE6C RDH5 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY NLK AXIN1 NR1C2 CTBP1 DVL1 DKFZp781N011 FRAT1 FZD1 CSNK2A1 MAP3K7IP1 HDAC1 CTNNB1 MYC HNF1A APC CCND1 PPP2CA WIF1 GSK3B MAP3K7 WNT1 CREBBP SMAD4 PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY F2 ROCK1 ROCK2 GNB1 ARHGEF1 HEL-S-47e ZYX PIK3R1 VASP GNAZ GNAI3 MYL2 GNAI1 GNA14 GNA15 GNA11 PIK3CA SNX1 SNX2 F2R F2RL2 TRPC6 PKN1 GNAO1 PLCB3 GNAQ PLCB1 PLCB2 PRKCB GNA13 PRKCA GNG2 BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY GNAS PRKAA1 PRKAB2 PRKAA2 ADCY1 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 PRKAR1B PRKAR1A PRKACG BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL2 IL4 CD40 CD40LG HLA-DRB5 HLA-DRB4 CD80 HLA-DRA FAS HLA-DRB3 HLA-DRB1 TNFSF6 IL10 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY EIF4EBP1 EGR1 RANBP9 RANBP10 MUC20 PXN WASL PAK4 MLST8 MAP2K4 PAK1 MAP3K1 APC SRC MAPK1 CDC42 NCK1 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A EIF4E ARF6 DKFZp434N101 RAC1 MAP2K1 PTPN1 MAPK3 CRKL PTPN11 PDPK1 GAB2 SNAI1 MAPK8 CBL MTOR PRKCI PIK3CA HRAS MAP2K2 F2RL2 NCK2 GRB2 SOS1 CTNNB1 RAF1 raptor INPPL1 DKFZp434G2016 DEPTOR HGS AKT1S1 NUMB DKFZp666O0110 RIN2 DKFZp686B23205 BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY RAN RANBP2 NUP214 NUP210 hCG_19665 RCC1 NUTF2 NUP153 KPNA2 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SLC2A4 SFN MAPKAP1 AKT3 MLST8 BAD TBC1D4 HEL2 RICTOR SRC CHUK FOXO3A FOXO4 PDPK1 FOXO1 MTOR YWHAQ HEL-S-1 GSK3A YWHAG PRKDC BCL2L1 CDKN1A CASP9 YWHAZ CDKN1B MAP3K5 RAF1 GSK3B BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY CASP3 FYN THBS1 JUN FOS MAPK14 CD36 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY MAPK8 PIK3CA CSNK2A1 JUN HRAS FOS GRB2 SOS1 MAP2K4 EGF STAT3 MAP3K1 SHC1 PIK3R1 RAF1 STAT1 DKFZp434N101 PRKCB MAP2K1 PRKCA MAPK3 JAK1 EGFR BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C3 HEL-S-76p TBP SSB GTF3C5 GTF3C1 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNB1 CREB1 SRC MAPK1 PIK3R1 CDC42 PLCG2 PELP1 GNRH1 SHBG DKFZp434N101 RAC1 MAP2K1 MAPK3 GNAZ GNAI3 GNAI1 PIK3CA HRAS MAP2K2 FOS GNAO1 PLCB3 RAF1 PLCB1 PLCB2 DKFZp666O0110 GNG2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY EGR1 SIRT1 HTATIP KAT2B NCOA1 RXRA JUN HDAC1 MAPK14 SMARCE1 MAP2K4 SMARCC1 REL CEBPA SRC CARM1 MDM2 TMPRSS2 KLK3 MAP2K6 NR2C2 HOXB13 ZMIZ2 CREBBP TRIM24 KAT7 SRY SPDEF NR3C1 MAPK8 DKFZp686P15142 FOXO1 POU2F1 RXRB NR0B1 APPBP2 PDE9A RXRG PKN1 GATA2 HDAC7 GSK3B EP300 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY F2 GNA14 GNA15 ROCK1 GNA11 ROCK2 GNB1 F2RL3 F2RL2 GNAQ PLCB2 GNA13 GNG2 MYL2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 MBD3 GREB1 HEL-S-162eP HDAC1 PDZK1 TUBA4A TUBA1A HEL-S-130P TUBA2 MTA3 HSPB2-C11orf52 HEL-S-87p HEL-S-102 SNAI2 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY SELP ITGAM SELE ITGA4 CD44 SELL PECAM1 ITGB1 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY CAPNS1 CAPNS2 ROCK1 JUN ZYX MAPK1 SHC1 ACTA1 FYN RAP1A MAP2K1 MAPK3 RAPGEF1 CRKL TLN1 MAPK8 HRAS MAP2K2 GRB2 SOS1 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR ACTN1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAPK8 JUN CREB1 FOS MAPK14 MAPK1 HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFF HMOX1 MAFK hCG_1991559 PRKCB NFE2L2 PRKCA BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY CD3G LCK CD3E CD3D PTPRC ADCY1 CSK CD247 HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 PRKAR1B ZAP70 PRKAR1A CREBBP PRKACG BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY F2 ROCK1 PIK3CA PTK2B ARHGEF1 F2RL3 F2R ADCY1 GNAQ PPP1R12B PIK3R1 PLCB1 MAP3K7 PRKCB PRKCA GNA13 BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY NR1H4 RXRA FABP6 ABCA1 LDLR NR0B2 BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY HTATIP MDC1 ABRAXAS1 RNF8 SMC3 RAP80 TP53BP1 SMC1A TERF2 HEL-S-71 RFWD2 RBBP8 H2AX BLM MDM2 NBN CTBP1 HEL-S-1 ATM MRE11A RAD50 CHEK2 FANCD2 BRCA1 RAD17 TRIM28 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY NCOR2 RBL1 JUN HRAS FOS HDAC5 CSF1R CSF1 ETV3 ETS2 SIN3B HDAC2 SIN3A E2F4 BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY PTPN11 IL2 PIK3CA CD3G LCK CD3E CD3D GRB2 CD247 HLA-DRB5 HLA-DRB4 CD80 PIK3R1 HLA-DRA HLA-DRB3 HLA-DRB1 ITK CTLA4 ICOS PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY LNPEP GYS1 TRIP10 SLC2A4 STX4A PRKCI VAMP2 INS SFN YWHAQ HEL-S-1 YWHAG TBC1D4 HEL2 STXBP4 YWHAZ PPP1CC PRKCZ GSK3B HEL-S-42 INSR ASIP PPP1R3A BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY MMP9 MMP14 TIMP1 RECK TIMP4 HRAS TIMP3 MMP2 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY UBE2I MAPK1 NUP214 CTDSP1 CTDSP2 NUP153 CTDSPL KPNA2 SMAD2 MAPK3 SMAD4 MAP3K1 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY APC MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 DVL1 TGFBR1 TGFBR2 TGFBR3 FZD1 BMP10 BMPR2 CTNNB1 GATA4 ATF2 NPPB HNF1A DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C RFC1 NOG SMAD6 BMP7 GSK3B BMP5 WNT1 BMP4 BMP2 BMPR1A BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY PPP3CA CAMK1 PPP3CC CAMK1G IGF1 IGF1R CALM3 PIK3CA CALM2 MAPK14 HDAC5 PIK3R1 MAP2K6 NFATC2 INSR MAPK7 NFATC1 MYOD1 CABIN1 AVP BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 SUMO1 FLJ00340 PAX3 PRAM1 RARA HRAS PML RB1 FAS TNFRSF1B TNFRSF1A TNF-alpha TNFSF6 CREBBP PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY DKFZp781O1323 ACVR1 SMAD1 AMHR2 TLX2 SMAD9 FKBP1A AMH BMP7 BMPR2 SMAD4 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4EBP1 PDPK1 GHR EIF4A1 MTOR RPS6KB1 EIF4G1 PIK3CA PABPC1 PDK2 MAPK14 MKNK1 MAPK1 PIK3R1 EIF4E IRS1 PRKCB EIF4A2 PRKCA MAPK3 AAG1 PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R3 PIK3CD SYK PIK3R2 ARF1 DAPP1 NRAS BLNK PLEKHA1 PLEKHA2 SRC LYN BTK BLK SGK1 YES1 LAT PIK3R1 ARF5 FYN PLCG2 RAP1A c-fgr ITK KRAS ARF6 DKFZp434N101 RAC1 FOXO3A PTEN PDPK1 PIK3CA LCK HRAS CYTH3 CYTH2 INPPL1 PIK3R5 ZAP70 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY CS DKFZp564P2062 FH HEL-S-32 OGDH ACO2 SDHA PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A IKBKB EGR2 PML SP1 CHUK BAX TP53I3 FAS GPX2 MDM2 DICER1 SMARCD3 OGG1 CABL1 NOC2L EVPL ADA ITGB4 CLCA2 FLOT2 CDKN2A BBC3 NQO1 TFAP2C DST WWP1 AEN YWHAQ SSRP1 DHRS3 TRAF4 SHH ITCH PLK1 CDKN1A FDXR TP63 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY SMURF2 CCNB1 SMURF1 CDC2 SFN CDK2 CDK5 CDK8 CDK7 CDK3 TRIM25 CCNB2 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY VAMP2 CHRNA1 SNAP25 CHRM1 STX1A PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY DKFZp686I05169 CCNB1 NUDC ROCK2 PAK1 PPP2R1A PPP2CA CDC2 RAB1A ECT2 ERCC6L AURKA PLK1 BUB1B seTCTP SGOL1 WEE1 CDC14B GOLGA2 DKFZp686G14213 CDC20 KNTC2 HEL-S-80p CLSPN FBXO5 NINL HCTP4 CENPU INCENP C13orf34 FZR1 TUBG1 CENPE KIF20A PRC1 GORASP1 KIZ PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 SKP2 PAX3 CCNA2 TFDP1 CCNE1 CEBPA TBP RBBP4 E2F2 E2F3 E2F4 MAPK11 CSF2 CEBPB CREBBP CEBPD CDKN2A DKFZp686H0575 CDK2 CCND1 SPI1 SUV39H1 AATF BRD2 SFTPD RUNX2 UBTF RBP2 ATF7 HDAC3 MITF-C JUN HDAC1 BGLAP PPARG MAPK9 GSC MAPK14 CBX4 PPP2R3B TAF1 SMARCA4 PPP2CA CCND2 MDM2 CDK6 CTBP1 RB1 ATF2 CDKN1A CDKN1B RAF1 MEF2C CCND3 CDK4 EP300 MYOD1 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY MYT1 WEE1 DKFZp686G14213 CDC2 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY EGR1 SFN NGF CREB1 NRAS BAD HEL2 CAMK4 AGAP2 SRC TRPC3 CAMK2A TRPV1 SHC1 NTRK1 PIK3R1 KRAS DKFZp434N101 FOXO3A PDPK1 YWHAQ PIK3CA HEL-S-1 HRAS YWHAG GRB2 SOS1 CCND1 YWHAZ GSK3B BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY PPP3CA NR1C1 CAMK1 PPP3CC CAMK1G ESRRA SLC2A4 CALM3 CALM2 PPARGC1A HDAC5 CAMK4 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PIK3R1 CDC42 PIK3CA WASL RAC1 PDGFRA PAK1 PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 CRK PDPK1 IGF1R RPS6KB1 PIK3CA PXN HRAS NCK2 GRB2 SOS1 BAD HEL2 YWHAZ SHC1 PIK3R1 GRB10 RAF1 PRKD1 PRKCZ IRS1 PTPN1 DKFZp666O0110 CRKL BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY CD247 FAS PRF1 HLA-A B2M CD3G CD3E TNFSF6 CD3D BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY FBL GPT EIF4E NCL MAPK14 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY SDHB SLC25A6 ZNF183 GPD2 SDHA UQCRC1 SDHC SDHD SLC25A4 HEL-S-123m BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY GNAS DKFZp686K0257 IGF1R NGFR NGF RPS6KA5 DPM2 MAP2K2 HRAS GRB2 SOS1 ITGB1 STAT3 MYC MKNK1 MAPK1 SHC1 RAF1 PPP2CA RPS6KA1 PDGFRA MAP2K1 MAPK3 EGFR PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY MAPK8 CDC2 RBP1 NR1B3 RXRB NCOR2 KAT2B NCOA1 NR1i1 RARA HDAC3 RARB CDK7 RXRA HDAC1 RXRG CCNH MAPK14 MNAT1 MAPK1 EP300 CREBBP PRKCA MAPK3 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY PPP3CA PPP3CC MARCKS CALM3 CALM2 SP1 SP3 CDKN1A NFATC4 GNAQ NFATC3 DKFZp434N101 PRKCB NFATC2 PRKCA NFATC1 BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 PTGER3 EPHX1 PTGS2 PTGS1 ALOX5 ALOX5AP TBXAS1 PTGES PLCB1 PTGER1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY CTNND1 TIAM1 SRC FYN CDC42 RAB5A CDH2 CTNNA1 RAB7A ARF6 hCG_1991735 RAC1 PTPN1 CABL1 CREBBP JUP IGF1R SNX1 HRAS CTNNB1 EGF CASP3 RET ROBO1 SLIT1 DSP NTRK2 MMP7 PTPN6 BDNF MMP3 IGF2 HGS ADAM10 GNA13 ZBTB33 GDNF RIN2 EGFR MEP1B BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY RBPJ PSEN1 FURIN NOTCH1 ADAM17 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY CTNND1 CYFIP2 NCKAP1 AQP5 LPP ROCK1 AQP3 LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 ZYX KIFC3 DKFZp762K123 EXOC4 VASP NCK1 CTNNA1 PIP5K1C ARF6 AFDN MYL2 NECTIN2 STX4A IGF1R CTNNB1 EGF HEL114 HGF ACTN1 EFNA1 EPHA2 EGFR BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY SUMO1 RAN RANBP2 MDM2 PIAS1 HDAC1 HDAC4 DKFZp566E044 HDAC9 PIAS2 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IFNGR1 IL18 IFNGR2 IL2 IL4 IF2F IL2RA CD40 IL12RB1 IL18R1 NR1i2 CD40LG HLA-DRB5 IL12B HLA-DRB4 IL12A HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY MAPK8 NFKB1 MAPK14 CHUK TWEAK TNFSF13 TRAF2 TNFRSF13C DKFZp686J04131 RELA TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY BIRC3 CASP6 CASP10 hCG_16983 LMNB2 CASP9 CASP3 hCG_20684 CASP4 ARHGDIB PRF1 LMNA DFFB DFFA PARP1 APAF1 BIRC2 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY IL6 JUN MAPK14 IKBKB MAP2K3 NFKBIA IL1RN MAP3K1 IRAK1 CHUK IL1R1 IRAK3 DKFZp686J04131 RELA IL1B MYD88 MAP3K7 TRAF6 IRAK2 MAP2K6 TGFB1 MAPK8 NFKB1 MAP3K7IP1 IL1A TNF-alpha IF1DA1 IFNA1 BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY HLA-DRB5 HLA-DRB4 HLA-DRA HLA-A HLA-DRB3 B2M HLA-DRB1 TAP1 PSMB6 CD74 TAP2 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY S1PR1 PIK3CA ADCY1 ITGB3 MAPK1 SMPD2 PIK3R1 PLCB1 PDGFA ITGAV SMPD1 PRKCB RAC1 PDGFRA PRKCA MAPK3 SPHKAP SPHK1 BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY MBTPS1 SREBF2 MBTPS2 LIMA1 HMGCS1 LDLR PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3R3 PIK3CD PIK3R2 IKBKB MAP2K4 TNFRSF10C MAP3K1 TNFRSF10A CHUK TNFRSF10D MAPK1 TRADD PIK3R1 TRAF2 RIPK1 SMPD1 IKBKG DKFZp686A24188 MAPK3 MAPK8 TNFSF10 DAP3 CASP10 PIK3CA hCG_16983 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 IL1A IL1R1 TRADD FADD DKFZp686J04131 RELA TNFRSF1B TNFRSF1A RIPK1 MYD88 TNF-alpha TRAF6 IKBKG MAP3K7 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 TIMELESS WDR5 CRY1 BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 TBP NCOR2 KAT2B NCOA1 RARA RXRA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGAP5 ROCK1 ARHGAP4 OPHN1 PIP5K1A ARHGEF1 ARHGEF11 HEL114 ARHGAP1 BAIAP2 STM7 PPP1R12B PFN1 LIMK1 ARHGEF5 MYL2 TLN1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EEA1 RAB5A TF HGS DKFZp686O0451 EGF EGFR BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY CBL HRAS GRB2 SOS1 EGF MAPK1 SHC1 RAF1 SPRY4 PTPRB SPRY2 SPRY1 MAP2K1 MAPK3 EGFR PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNAI1 S1PR1 GNA14 VEGFA GNA15 GNA11 GNAO1 AKT3 SRC ITGB3 GNAQ MAPK1 CXCR4 FLT1 ITGAV EDG5 S1PR3 RAC1 GNA13 MAPK3 GNAZ GNAI3 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAPK8 PIK3CA STAT5B JUN HRAS FOS GRB2 SOS1 MAP2K4 BAD MYC MAP3K1 PIK3R1 RAF1 STAT1 BCR MAP2K1 MAPK3 CRKL BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY GNAS CCL11 ROCK2 CCR3 HRAS GNAQ MAPK1 PPP1R12B RAF1 PLCB1 LIMK1 PRKCB PIK3C2G MAP2K1 PRKCA MAPK3 MYL2 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY ORC3 MCM5 CDC6 MCM6 MCM2 KITLG CDK2 CCNE1 CDKN1B ORC1L CDT1 MCM7 ORC2L ORC6L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAPK8 NFKB1 AIFM1 BCL2 hCG_16983 MAP2K4 BAD MAP3K1 MAPK1 TRADD BAX RAF1 TRAF2 FADD RELA TNFRSF1A RIPK1 SMPD1 NSMAF MAP2K1 MAPK3 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY STAT1 STAT2 IFNAR2 TYK2 IRF9 IFNAR1 IF1DA1 IFNA1 JAK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ARF1 ASAP1 ARFGAP3 GPLD1 ARAP1 CYTH3 CYTH2 ARAP2 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY SIRT1 KAT2B RANBP2 HDAC4 DKFZp566E044 HDAC9 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC3 HDAC1 PPARG MAX NFKBIA HDAC10 HDAC5 STAT3 HDAC11 CHD4 CHD3 MBD3L2 SMG5 SIN3B SIN3A SIRT4 SIRT5 SIRT6 RELA SIRT7 SIRT2 WDR77 SIRT3 SAP30 FKBP3 ZFPM1 HDAC8 GATA1 SAP18 RBBP7 MTA2 SMURF1 MBD2 NFKB1 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 TNF-alpha EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY PPP3CA PPP3CC CALM3 CALM2 JUN SYK MAP2K4 MAP3K1 LYN NFATC4 BTK MAPK1 SHC1 PIK3R1 DKFZp434N101 MAP2K1 MAPK3 MAPK8 PIK3CA FCER1A HRAS FCER1G MS4A2 FOS GRB2 SOS1 NFATC3 RAF1 VAV1 PRKCB NFATC2 NFATC1 PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DYNLT1 TIAM1 NGFR NGF NRAS MAPK1 NTRK1 SHC2 CDC42 RAP1A KRAS RAPGEF1 CRK CCND1 RASGRF1 STAT3 SHC1 PIK3R1 ELMO1 PRKCZ DKFZp434N101 RAC1 MAP2K1 MAPK3 CRKL PTPN11 GAB2 PRKCI PIK3CA MCF2L HRAS MATK GRB2 FRS2 SOS1 FRS3 FAIM SHC3 MAGED1 NTF5 NTF3 SH2B1 NTRK3 ARHG RIT1 NTRK2 RIT2 BDNF SQSTM1 DOCK1 PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY WASF2 CYFIP2 ARPC1B MAP2K5 EGR1 NCKAP1 MAP3K2 ACTR3 MYLPF ACTR2 PPP5C RPS6KA5 WASL CREB1 MAPKAP1 ATF1 MLST8 MAP2K4 NRAS RICTOR BRAF MAP3K1 ARPC4 SRC ARPC5 MAPK1 BAIAP2 ARPC2 ARPC3 CDC42 KRAS hCG_1991735 VAV2 PEBP1 FOS PRKCA RALA RIN1 SFN PLD2 PIK3R3 PIK3CD JUN PIK3R2 MAPK9 BAD HEL2 STAT3 PPP2R2A PPP2R1A PIK3R1 PRKCZ PPP2CA RAB5A RAC1 MAP2K1 MAPK3 RPS6 PDPK1 MAPK8 MTOR YWHAQ PIK3CA HEL-S-1 HRAS MAP2K2 F2RL2 YWHAG GRB2 SOS1 EGF BCL2L1 ATF2 YWHAZ RAF1 SMAD1 MEF2C STAT1 USP6NL ARF4 BRK1 RPS6KA4 RPS6KA3 ZFP36 MAPK7 KSR1 SH2D2A EGFR BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY IGF1R TNKS XRCC5 TERF1 TEP1 BCL2 MYC RB1 PPP2CA TERT KRAS PRKCA EGFR BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY IRF4 NFKB1 KAT2B JUN IRF3 IRF1 IRF2 IRF7 ATF2 IRF5 RELA CREBBP HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAP2K5 MAP3K2 RPS6KA5 CREB1 MAPK13 DKFZp686M02159 MAP2K3 RPS6KA2 MAP2K4 MAP3K8 MAP4K2 PAK1 MAP3K6 MAP3K1 CHUK CEBPA MAPK6 MAPK1 MAPK4 TRADD RPS6KB2 MAP3K10 TRAF2 MAP3K13 DKFZp686J04131 MAPK11 RIPK1 MAP2K6 MAP3K12 FOS RPS6KA1 JUN MAX MAPK9 MAPK14 IKBKB NFKBIA SP1 MYC MAPK10 SHC1 RELA MAP3K7 RAC1 MAP2K1 MAPK3 HEL-S-31 TGFB1 MAPK8 NFKB1 TGFBR1 RPS6KB1 HRAS MAP2K2 GRB2 MAP3K11 ATF2 MKNK1 MAP3K5 RAF1 STAT1 RAPGEF2 MAPKAPK5 MAP4K1 RPS6KA4 RPS6KA3 MAPKAPK3 MAPK7 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY CCNB1 SIRT1 SKP2 RAN RBL2 SFN KAT2B MAPK9 GADD45A IKBKB HEL2 CHUK MAPK10 SGK1 RALB DKFZp564M2422 BCL6 BCL2L11 CSNK1G3 CSNK1D FBXO32 TNFSF6 ZA20D2 CSNK1G2 FOXO3A CSNK1G1 CREBBP FOXO4 MAPK8 FOXO1 YWHAQ CDK2 HEL-S-1 CSNK1A1 CSNK1E YWHAG CTNNB1 PLK1 YWHAZ CDKN1B G6PC1 EP300 RALA PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY CRK MAPK8 JUN MAP2K4 MAP3K8 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 LCP2 CRKL BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY hCG_37731 TREX1 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG FANCF RAD50 FANCD2 CHEK2 BRCA1 RAD17 RAD9A BRCA2 ATR CHEK1 RAD51 NBN PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PIK3R3 WASL PIK3CD PIK3R2 NRAS PAK1 STAT3 SRC MAPK1 SHC1 PIK3R1 NCK1 PIP5K1C KRAS DKFZp434N101 PTPN1 MAPK3 GNAI3 TLN1 GNAI1 PTPN11 PIK3CA HRAS NCK2 GRB2 SOS1 EGF STAT1 PTPN6 DKFZp666O0110 EGFR BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY BIRC3 TRADD BAG4 TRAF2 FADD TNFRSF1B TNFRSF1A RIPK1 TNF-alpha hCG_16983 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY NR1C1 PGLYRP1 TLR3 MAPK8 NFKB1 EIF2AK2 JUN MAP3K7IP1 FOS MAPK14 MAP2K3 IKBKB MAP2K4 NFKBIA MAP3K1 TLR7 CHUK DKFZp686J04131 RELA MYD88 TRAF6 IKBKG MAP3K7 MAP2K6 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY ADRBK1 GNAS MAPK1 RAF1 PLCB1 MAP2K2 MAP2K1 KCNA1 ADCY1 MAPK3 KCNA2 KCNA3 BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY IL18 KLRC2 KLRC3 KLRC4 KLRD1 PIK3CA KLRC1 PTK2B SYK ITGB1 PAK1 LAT PIK3R1 HLA-A VAV1 B2M PTPN6 RAC1 MAP2K1 MAPK3 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF4EBP1 PDPK1 IGF1 MTOR IGF1R RPS6KB1 PIK3CA PDK2 PIK3R1 EIF2B5 PPP2CA INPPL1 EIF4E GSK3B EIF2S2 EIF2S1 EIF2S3 PTEN BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY MAPK8 CASP6 CASP10 FAF1 PTPN13 JUN RIPK2 hCG_16983 MAP2K4 PRKDC PAK1 RB1 MAP3K1 LMNB2 CASP3 ARHGDIB FAS FADD LMNA DFFB DFFA PARP1 TNFSF6 MAP3K7 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABARAP GABRA2 GABRA6 GABRA5 GABRA4 GABRA3 UBQLN1 GPHN BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP1A2 CYP2E1 NR1H4 ABCG1 NR1C2 NR1B3 NR1i1 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 ABCC3 CYP4A22 ABCB1 CYP3A4 ABCB4 CYP27B1 CYP2B6 ABCB11 ABCG5 ABCC2 CYP4A11 CYP4B1 CYP8B1 CYP26A1 ABCA1 CYP2C9 NR0B2 CYP24A1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY RBPJ MAML2 KDM1A MAML1 RUNX2 NCOR2 GATA6 ASCL1 NCOA1 HEY1 HEY2 HDAC1 BGLAP SPEN HES6 GAA NOTCH1 RCAN1 STAT3 ID1 PTF1A NEUROG3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D GATA4 RB1 CDKN1B HIF1A YY1 TWIST1 PARP1 EP300 TCF3 MYOD1 BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY CD3G LCK CD3E CD3D PTPRC CD247 HLA-DRB5 HLA-DRB4 HLA-DRA FYN HLA-DRB3 HLA-DRB1 ZAP70 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4EBP1 PDPK1 EIF4A1 MTOR RPS6KB1 EIF4G1 PIK3CA PDK2 EIF3A TSC1 MKNK1 RHEB PIK3R1 PPP2CA TSC2 EIF4E EIF4A2 AAG1 PTEN PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY COL4A4 COL4A3 SPP1 COL4A6 VEGFA COL4A5 THY1 COL1A1 ITGB3 F11R VTN EDIL3 L1CAM SDC1 CD47 ITGAV FBN1 PECAM1 HMGB1 KDR SPHK1 LAMA4 PLAUR LAMC1 TGFBR2 IBSP SDC4 FGA LAMB1 COL1A2 TNC ITGA2B THBS1 HEL-S-78p CYR61 TGFBI COL4A1 PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY KIAA0142 DKFZp781H1715 TIAM1 HEL-S-47e KALRN ELMO1 DOCK2 ARHGAP17 PREX2 CHN1 RAC1 ARHGAP9 RALBP1 VAV2 SPATA13 TRIO ARHGEF25 VAV3 ARHGEF2 SOS1 ARHGAP1 DEF6 VAV1 BCR RASGRF1 DOCK1 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY TIRAP TLR1 TLR3 CD14 TLR4 S100A9 S100A8 IKBKB CHUK IRAK1 VCAN HSPD1 IRAK4 MYD88 IKBKG IRAK2 HMGB1 LY96 TICAM1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY BIRC3 NFKBIA MAP3K1 CHUK CRADD TRADD hCG_20684 TRAF2 FAS DKFZp686J04131 RELA TNFRSF1A MDM2 RIPK1 TNFSF6 PSEN1 MAPK8 CASP6 NFKB1 PSEN2 ACTG1 CDK11A BCL2 hCG_16983 NUMA1 PRKDC RB1 LMNB2 CASP9 CASP3 BAG4 MAP3K5 ARHGDIB FADD LMNA TRAF1 DFFB TNFRSF1B DFFA TNF-alpha PARP1 APAF1 BIRC2 BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY GNAQ PLCB1 NFKB1 RELA PRKCB NFKBIA PRKCA BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY MAPK8 NFKB1 ATM JUN TP73 GADD45A MRE11A NFKBIA CDKN1A RAD50 RBBP8 CHEK2 BRCA1 RELA MDM2 CHEK1 RAD51 NBN PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY ADRBK1 UBE2I SUMO1 RAN RANBP2 NCOR2 GNB1 HDAC3 HDAC4 DKFZp566E044 HDAC5 HEL2 HDAC10 HDAC9 CAMK4 HDAC11 BCL6 GATA1 NR3C1 HEL-S-1 TUBA1B RFXANK TUBB2A BCOR ANKRA2 GATA2 MEF2C HDAC7 GNG2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELE CD44 SELL PECAM1 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY EGR1 MAPK1 RAF1 NGFR NGF DPM2 CDK5 MAP2K2 HRAS MAP2K1 MAPK3 CDK5R1 PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY RUVBL1 KIAA0142 PXN HEL-S-28 JUN CREB1 ZYX RICTOR CDC42 hCG_1991735 RAC1 SNAI1 NCK2 CTNNB1 ILKAP AURKA CCND1 GIT2 PPP1R14A TNS1 PPP1R14B PPP1R14C PARVA PARVB ARHG hCG_2016482 PARVG CDC37 ELMO2 GSK3B PARP1 LIMS1 ACTN1 CKAP5 RUVBL2 TACC3 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY GNAI1 S1PR1 GNA14 GNA15 GNA11 GNAO1 GNAQ ABCC1 EDG5 SPHK2 S1PR3 SGPP1 SGPL1 GNA13 S1PR5 GNAZ S1PR4 SPHK1 GNAI3 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 AP2M1 CLTA PLD2 PIP5K1A COPA GBF1 CLTB ARF1 ASAP1 CYTH2 RAC1 KDELR1 AP2A1 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 STIL DHH HHIP PTCH2 PIK3CA IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY EPO IGF1 IL3 CCL3 KITLG IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 TGFB1 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY CHAF1A NGF BTG2 PRMT1 CHAF1B RB1 BTG1 CCND1 PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY ROCK1 EFNA5 SRC LYN EPHA7 BLK EPHA8 YES1 UNQ6114 EPHA4 EFNA3 FYN EFNA2 EPHA1 c-fgr EPHA3 DKFZp434N101 VAV2 CRKL CRK CBL LCK CDK5 VAV3 ARHGEF15 PIK3R5 EFNA1 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 UBE2M HEL-S-62p NR0B1 NCOA1 UBA3 DDX54 ZNF14 ESR2 SMARCE1 NEDD8 NR0B2 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY MAPK1 MTOR TYK2 JAK3 MAPK3 STAT3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY CASP9 HSPB2-C11orf52 IL1A ACTA1 CASP3 HEL-S-102 FAS TNFSF6 TNF-alpha BCL2 MAPKAPK3 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA1 ELANE IL8 GRN CELA2A CELA3B SLPI ELA2B PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY FOXO4 SIRT1 ACSS2 FHL2 FOXO1 HOXA10 KAT2B HIST1H1E MEF2D HIST1H4J ACSS1 TUBA1B TUBB2A HDAC4 PPARGC1A CDKN1A BAX SIRT7 SIRT2 SIRT3 EP300 FOXO3A CREBBP MYOD1 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY CD3G CD3E CD3D PRKCE BCL10 IKBKB NRAS MAP3K8 CHUK CD247 SHC1 LAT FYN PRF1 HLA-A DKFZp686J04131 RAP1A B2M IKBKG TRAF6 KRAS DKFZp434N101 GRAP2 LCP2 PDPK1 CBL LCK FLJ00120 FLJ14466 HRAS PAG1 PTPRC CD8B1 GRB2 TRPV6 SOS1 STIM1 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB ZAP70 PRKCA CD8A BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY PDPK1 PIK3CA HEL-S-28 PDK2 GRB2 SOS1 ITGB1 CDKN1B MAPK1 SHC1 PIK3R1 TNFSF6 FOXO3A MAPK3 PTEN EGFR PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY SNTA1 PKN1 MAP2K6 MAPK13 MAP2K3 DKFZp686M02159 EEF2K CCND1 pk PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY MMP9 CCNA2 IL6 JUN BGLAP SP1 LIF FLJ23306 CXNK2 CCL2 FOSL1 ITGB4 CDKN2A PLAUR MMP2 CCND1 COL1A2 LAMA3 TXLNG THBD NFATC3 JUNB JUND USF2 DCN DMTF1 IL8 MGP HMOX1 IVL EP300 ATF4 NFATC2 NFATC1 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY HBB DKFZp686P18130 CPOX HBA2 ALAS2 ERAF UROD UROS ALAS1 HMBS GATA1 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI IL7 IL7R PIK3CA STAT5B LCK PTK2B BCL2 PIK3R1 FYN EP300 CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY F2 COL4A4 COL4A3 COL4A6 COL4A5 F11 APP F9 SERPINE1 PLG PLAT COL4A2 COL4A1 BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY PAPOLA CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 CPSF2 CSTF2 CSTF1 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY IL18 IL4 IF2F CD3G CD3E CD3D MAP2K3 CD247 IL12B IL12A MAP2K6 CCL4 CCL3 TYK2 CD8B1 FOS STAT4 CCR5 IL12RB1 IL18R1 NOS2 PPP3CA SOCS1 RIPK2 STAT6 MAPK14 STAT3 IL18RAP IL1R1 RELB PPP3R1 IL2RG HLX HLA-A TBX21 B2M IL1B RELA GADD45B RAB7A GZMA GADD45G NFKB2 TNFSF6 IL2 MTOR NFKB1 LCK IL2RA IL2RB ATF2 HLA-DRA STAT1 SPHK2 CD8A BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY PPP3CA PPP3CC CALM3 CALM2 CD3G CD3E CD3D JUN MAP2K4 NFKBIA MAP3K1 NFATC4 CD247 SHC1 LAT PIK3R1 FYN RELA DKFZp434N101 RAC1 MAP2K1 MAPK3 MAPK8 NFKB1 PIK3CA LCK HRAS FOS GRB2 SOS1 NFATC3 RAF1 VAV1 PRKCB NFATC2 ZAP70 PRKCA NFATC1 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CDKN2A MTOR TGFBR1 RPS6KB1 TGFBR2 PIK3CA TGFBR3 MYC DKFZp781O1323 CDKN1B SMAD1 PIK3R1 PPP2CA MDM2 CTCF CD79B CD79A SMAD4 TGFB1 PTEN BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY GNAQ PPP1R12B ARHGAP5 PLCB1 ROCK1 ARHGEF1 PKN1 PRKCB GNA13 PRKCA PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY PTP4A1 EGR1 PTP4A2 PTP4A3 ATF5 CCNA2 ROCK1 CDK2 TUBA1B ITGA1 CCNE1 ITGB1 CDKN1A SRC MAPK1 RAC1 hCG_2043376 MAPK3 RABGGTB RABGGTA PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY KIAA0142 ITSN2 DOCK9 ITSN1 FGD1 DOCK10 MCF2L DOCK11 HEL-S-47e ARHGEF9 VAV3 APC ARHGAP1 CDC42 ARHGAP17 FARP2 DKFZp434N101 RALBP1 VAV2 SPATA13 ARHGEF25 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY F2 SERPINE1 PLG HEL-S-78p F2R CPB2 SERPINB2 F13A1 PLAT FGA PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY WASL PAK1 AGAP2 SRC CAMK2A MAPK1 YES1 PIK3R1 FYN ELMO1 CDC42 NCK1 DKFZp434N101 RAC1 MAP2K1 MAPK3 TRIO PIK3CA MAP2K2 MAP1B HEL-S-36 NTN1 MYO10 UNC5A UNC5B DCC DOCK1 DKFZp666O0110 PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAP2K4 MAP3K1 CHUK BTK MAPK1 LAT IKBKG LCP2 SPHK1 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 SYK JUN IKBKB LYN SHC1 PIK3R1 FYN Pe1Fe6 RELA ITK DKFZp434N101 MAP2K1 MAPK3 PTPN11 GAB2 MAPK8 CBL NFKB1 PIK3CA FCER1A HRAS FCER1G MAP2K2 MS4A2 GRB2 SOS1 WIPF1 RAF1 LAT2 DOK1 VAV1 PPAP2A HCLS1 PLA2G1B FCGR2B DKFZp666O0110 BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 HEL-S-62p CFD ADIB ADIC C1S ADIA C1R BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 DFFB GZMA DFFA SET APEX1 HMGB2 CREBBP BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 FUT9 MAN1A2 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY MMP9 CAMK4 APC TBXT TCF7L1 ZCCHC12 CHD8 CBY1 DKFZp586H0919 MED12 SALL4 PP2150 PITX2 CDKN2A TLE4 DKFZp586M1622 MYOG TLE2 KRT1 CTNNBIP1 AXIN2 DKK4 FGF7A MDFIC TBL1XR1 CACNA1G IGF2BP1 TBL1X CCND1 TCF7L2 SKP1 CDX4 CDX1 KLF4 BCL9 SP5 TCF4 NEUROG1 CYR61 MYF5 DKK1 INCENP SFN ID2 MITF-C JUN HDAC1 HEL2 MYC SMARCA4 CCND2 TERT SNAI2 CTBP1 YWHAQ HEL-S-1 YWHAG MMP2 CTNNB1 YWHAZ VCAN TRRAP HDAC2 IL8 TNIK EP300 RUVBL2 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY GHR SLC2A4 GH1 PIK3CA STAT5B SOCS1 HRAS GRB2 SOS1 HNF1A MAPK1 SHC1 PIK3R1 RAF1 RPS6KA1 PTPN6 IRS1 DKFZp434N101 PRKCB MAP2K1 INSR PRKCA MAPK3 BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY RBPJ DVL1 FZD1 HES7 GSK3B HEY2 DKFZp434N181 WNT1 NOTCH1 HES1 HNF1A BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C4B_2 C8A C2 C4A C6 C7 C9 HEL-S-62p ADIB ADIC C1S ADIA C1R BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 SYK BAD MYC MAPK1 SHC1 PIK3R1 IL2RG FAS TNFSF6 JAK3 MAPK3 JAK1 CRKL CBL RPS6KB1 PIK3CA STAT5B IL2RA HRAS IL2RB BCL2 FOS GRB2 SOS1 RAF1 PTPN6 IRS1 IKZF3 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY LYN PTPN11 PIK3R1 PIK3CA CSF2RB STAT5B IL5 PIM1 SDCBP GRB2 CISH IL5RA PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY STK11 KIAA0999 MAP2 MARK4 MARK2 SFN STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK1 SNF1LK2 MLST8 HEL2 MYC TSC1 PRKAG1 SMARCD3 SMAD4 EZR MTOR PSEN2 YWHAQ HEL-S-1 PRKAA1 YWHAG PRKAA2 HEL-S-130P YWHAZ raptor TSC2 CDC37 GSK3B PRKAB1 AKT1S1 BRSK1 CRTC2 CAB39 PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY APTX NHEJ1 XRCC5 CSNK2A1 CSNK2A2 POLM PNKP PRKDC APLF CSNK2B DNTT PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY CD3G CD3E CD3D PRKCE NRAS MAP3K8 CHUK CD247 LAT CDC42 NCK1 DKFZp686J04131 RAP1A IKBKG TRAF6 KRAS GRAP2 LCP2 FLNA FLJ00120 FLJ14466 PAG1 TRPV6 STIM1 CSK PTPN6 PRKCB ZAP70 PRKCA IKBKB BCL10 SLA2 SHC1 WAS STK39 FYN FYB1 ITK DKFZp434N101 PTEN PTPN11 PDPK1 GAB2 CBL LCK HRAS PTPRC GRB2 SOS1 PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAPK1 RAF1 KRAS HRAS PRKCB FOS MAP2K1 NRAS PRKCA MAPK3 MAP3K8 BRAF BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAG1 LEP LEPR ACACA CPT1A PRKAB1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY IL2 IL4 TGFBR1 TGFBR2 IF2F CD3G TGFBR3 CD3E IL2RA CD3D CD247 TOB2 TOB1 SMAD4 TGFB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNAI1 MAPK1 CDC42 DKFZp434N101 GNAO1 GNA13 S1PR5 MAPK3 GNAZ S1PR4 GNAI3 BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A HEL-S-62p C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP2 GHRL IGFALS GH1 IGF1 IGFBP6 IGFBP1 IGFBP5 IGFBP4 SST DKFZp667A016 GHRH BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY PTPN11 IL6 IL6ST CSNK2A1 IL6R JUN HRAS FOS GRB2 SOS1 STAT3 SHC1 RAF1 MAP2K1 CEBPB JAK3 MAPK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY IL18 IL2 EBI3 STAT2 IL27 IL6 GATA3 IF2F IL27RA IL6ST TYK2 IL17A STAT4 IL12RB1 STAT3 IL12B IL12A STAT1 TBX21 IL1B TNF-alpha JAK1 TGFB1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY KCNIP3 JUN CREB1 OPRK1 PRKAR1B FOS PRKAR1A MAPK3 PRKACG CREM BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY ARHGAP5 ROCK1 PIK3CA HRAS ITGB1 MAPK1 SHC1 PIK3R1 RAF1 PFN1 FYN MAP2K1 MAPK3 MYL2 TLN1 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 AP2M1 PFKL PFKM RPS6KB1 GSK3A PRKCE PFKP ARF1 ARHGEF2 BAD LYN BTK EEA1 PRKCZ RAB5A GSK3B DKFZp434N101 RAC1 VAV2 AP2A1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY SPP1 VCAM1 VEGFA HEL-S-45 ADAM12 VEGFC VEGFD PXN KCNJ15 F13A1 ADAM2 ADAM15 ITGB1 ADAM8 PAOX SRC TNC CSF2 CSF2RA RAC1 NOS2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY PPP3CA DRD1 DRD2 PLCB1 PPP2CA CDK5 CSNK1D PPP1R1B PRKAR1B PRKAR1A PRKACG CDK5R1 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY IL1A HEL-S-10 IL10RB IL10RA IL6 STAT1 TNF-alpha HMOX1 IL10 STAT3 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL18 IL6 IF2F SOCS3 CD3E CXCL9 IL17A NFKBIA STAT3 IL18RAP IL12B PIK3R1 RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 ALOX12B CXCL1 MPO TNF-alpha IF2E IL19 IL23A NOS2 IL17F PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMA1 ITGB4 LAMA3 LAMC2 LAMC1 ITGA6 LAMB3 LAMB2 LAMA5 LAMB1 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY F2 COL4A4 SERPINC1 COL4A3 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PROS1 COL4A2 F7 COL4A1 PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY PPP3CA CHP1 BATF3 IL4 IL3 IF2F JUN RCAN1 CD40LG PPP3R1 CSF2 TNFSF6 FOSL1 IL2 POU2F1 FKBP1A IL2RA FOS PTGS2 NFATC3 JUNB NFATC2 NFATC1 AKAP5 CABIN1 BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CSF1 ACAT1 IL6 LPL CCL2 LDLR BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK1 CAMK1G CAMKK1 CALM3 CAMKK2 CALM2 CREB1 CAMK4 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG DKFZp761B2210 SRA1 PHB2 PDIA2 SET DSCAM LMO4 HDAC4 POU4F1 AP1B1 SAFB POU4F2 LCOR CHUK TFF1 TRIM59 PGR PRDM15 NCOR1 ATP5J HSF2 NDUFV3 XBP1 UBA3 DDX54 ABCA3 EBAG9 ESR2 CEBPB KLRC3 NR0B1 AXIN2 GREB1 HEL-S-130P CD82 CCND1 NEDD8 UBE2M HEL-S-62p NR0B2 NCOR2 NCOA1 MED1 PRL JUN HDAC1 MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 CD40LG DKFZp686J04131 RELA TRAF3 TRAF6 IKBKG IKBKAP PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM2 CCNA2 PPP2R1A PPP2CA MDM2 BRCA2 SMARCAL1 CEP164 CHEK1 PPP2R2B NBN RAD51 RFC3 RFC4 CDC6 RFC2 hCG_37731 TREX1 CDK2 HEL-S-1 RPA1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 CLSPN RAD17 RAD9A ATR TOPBP1 MCM7 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY GNAS PRKAR1B PRKCB PRKAR1A PRKCA GRK4 PRKACG PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY COL4A4 COL4A3 COL4A6 SPP1 COL4A5 ROCK1 PXN HEL-S-28 SRC ITGB3 MAPK1 F11R ITGAV COL16A1 KDR TLN1 COL14A1 COL12A1 PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 PIK4CA COL5A2 COL9A1 HEL114 COL9A3 PI4KB COL9A2 IRS1 VEGFA CSF1R COL1A1 CSF1 PIK3R1 VTN EDIL3 SDC1 RAC1 MAPK3 COL17A1 PTPN11 CBL RPS6KB1 TGFBR2 PIK3CA PTK2B hCG_16983 VAV3 COL3A1 COL1A2 CDKN1B FGF2 DKFZp666O0110 COL4A1 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY CBL ARHGAP35 TIAM1 PIK3CA VAV3 GRB2 PAK1 SRC SHC1 PIK3R1 INPPL1 RAC1 VAV2 EFNA1 DKFZp666O0110 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY SUMO1 UBE2F GPR37 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A4 COL4A3 COL4A6 COL4A5 P4HB SLC23A2 SLC23A1 SLC2A3 COL4A2 COL4A1 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS DKFZp762K123 DKFZp686P1551 SGK1 SHC1 EXOC4 PIK3R1 GRB10 PRKCZ PARD6A NCK1 EXOC6 EXOC5 EXOC2 EXOC1 FOXO3A PTPN1 HEL-S-42 INSR RAPGEF1 PTPN11 CRK PDPK1 TRIP10 CBL GRB14 PRKCI RPS6KB1 PIK3CA HRAS F2RL2 NCK2 GRB2 SOS1 DOK1 IRS1 SH2B2 PTPRA PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY ADRBK1 PDPK1 GNA14 CBL GNA15 GNB1 PRKCE PLCB3 LYN ARRB2 PLCB1 PLCB2 c-fgr RAB5A IL8 PRKCB PRKCA CXCR1 GNG2 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 DKFZp586M1622 DVL1 DVL2 AXIN2 CSNK1A1 CSNK1E GSK3A FZD5 WNT3A CTNNB1 APC SKP1 LRP6 CSNK1D GSK3B PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY PTPN11 GAB2 IL3 PIK3CA STAT5B PIM1 HDAC1 GRB2 YWHAG ID1 BCL2L1 YWHAZ SHC1 PIK3R1 CSF2RB IL3RA CISH CEBPB OSM SRP9 PRKACG CNKSR1 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY SERPINA1 SFTPA2 C4BPB DKFZp686I24235 NKX3-1 SFTPD INS GCG NR2F2 PISD NFIA JUN NFIB SCGB1A1 DSCAM AP1B1 SP1 TFF1 PRDM15 VTN ATP5J NDUFV3 XBP1 KLK3 COL18A1 CEBPB CREBBP APOB POU2F1 FOXA1 SHH FOS CDKN1B BRCA1 FOXA3 FOXA2 EP300 HEL-S-44 PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY MMP9 EGR1 IL4 IL6 IF2F IL5 CREB1 TH FLJ23306 BCL2L11 CSF2 CCL2 CDKN2A NR3C1 CDC2 DKFZp686H0575 EDN1 FOS CCND1 TCF7L2 NFATC3 JUNB GATA2 JUND HIF1A CYR61 DMTF1 hCG_1991559 NFATC2 ATF3 NFATC1 COPS5 JUN CRTC1 DMP1 MT2A SP1 MYC MAF CBFB NTS BAG1 ACTA1 PENK FABP4 TRIP6 HLA-A CXNK2 NPPA MYB FOSB FOSL1 PTEN TGFB1 IL2 TIMP1 CTNNB1 ATF2 COL1A2 CDKN1B IL8 EP300 IL10 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY CS SLC25A1 ACLY PC HEL-S-32 PDHA1 ME1 SLC25A11 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY NFKB1 JUN HRAS FOS NFKBIA MYC MAPK1 RAF1 PLCB1 RELA TNF-alpha PRKCB CUZD1 MAP2K1 PRKCA MAPK3 BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPA1 SNRPB2 SNRPE DKFZp434N041 SNRPF SNRPD3 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 SNRPG PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY TGFBR1 TGFBR2 TLX2 SMAD9 FKBP1A ACVRL1 INHBA ACVR2B ACVR2A BMPR2 ID1 CSNK2B ENG DKFZp781O1323 MAPK1 ACVR1 SMAD1 ARRB2 MAPK3 SMAD4 TGFB1 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY CAPNS1 EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 PRKAR1B PRKAR1A PRKACG EGFR MYL2 TLN1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY GTF2A1 SMARCC2 ARID1A SMARCA4 TBP NF1 NR3C1 SMARCE1 SMARCD1 PS1TP5BP1 SMARCC1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY GHR GH1 PIK3CA ERBB2 HRAS GRB2 SOS1 BAD CTNNB1 ITGB1 TFF3 TFF2 CASP9 TFF1 MAPK1 SHC1 PIK3R1 MAPK3 APAF1 EGFR BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY CARM1 RARA CREB1 RXRA EP300 PRKAR1B PRKAR1A CREBBP PRKACG BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY ZBTB7A CCT4 CASP3 PIK3R1 MTOR JUND PIK3CA BIRC5 FOS ITGB1 DPF2 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMA4 HEL-S-276 RPN2 PSMB2 PSMA2 PSMB3 RPN1 UBE3A UBE2A PSMB6 UBE1 BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY HEL-S-45 PRKCB ADRA1B PRKCA BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CD247 FAS CD3G CD3E TNFSF6 CD3D CCR5 BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY SAG RHO PDE6A SLC25A22 GRK1 RCVRN SLC25A18 PDE6G BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MPL THPO PIK3CA STAT5B CSNK2A1 JUN HRAS FOS GRB2 SOS1 STAT3 SHC1 PIK3R1 RAF1 STAT1 DKFZp434N101 PRKCB MAP2K1 PRKCA MAPK3 PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY IL6 IF2F SDC2 NGF LMO4 NRAS NTRK1 KRAS AFDN KDR IFNGR1 IGF1R ANGPT1 PAG1 IRS1 VEGFA SHC1 PIK3R1 IL2RG MAP2K1 JAK3 JAK1 GNAI3 GNAI1 PTPN11 GAB2 IL2 ARHGAP35 PIK3CA LCK IL6ST IL6R IL2RA HRAS MAP2K2 IL2RB GRB2 FRS2 SOS1 FRS3 EGF NTF5 NTF3 RAF1 NTRK3 STAT1 NTRK2 BDNF EGFR PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY BIRC3 AIFM1 PAWR EIF2AK2 PRKRA MAP2K4 BAD NFKBIA MYC MAP3K1 MAPK1 CRADD TRADD BAX TRAF2 PDGFA PRKCZ RELA TNFRSF1A RIPK1 SMPD1 MAP2K1 MAPK3 HEL-S-31 MAPK8 NFKB1 MAP2K2 BCL2 hCG_16983 HEL-S-130P EGF BAG4 RAF1 FADD TNF-alpha SPHK2 MADD KSR1 CYCS PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY WASF2 PIN1 ARPC1B ACTR3 ACTR2 WASL SLA HEL-S-47e ACTN4 SLC9A3R2 DOCK4 MYOCD NRAS BRAF ACTA2 PAK1 ARPC4 TAGLN ARPC5 SIPA1 BLK MAPK1 YES1 BAIAP2 ARPC2 ARPC3 NCK1 c-fgr KRAS RAB4A FOS PRKCA EIF2AK2 HEL2 MYC LYN SHC1 GRB10 PIK3R1 FYN PPP2CA RAC1 PTPN1 PTPN11 MAPK8 PIK3CA LCK MAP2K2 GRB2 SOS1 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 RAP1A ITGAV hCG_1991735 VAV2 AFDN PPP2R2B RAPGEF1 SPHK1 CRK S1PR1 STAT5B PAG1 CSK JUND PIK3R5 SLC9A3R1 SFN PIK3R3 JUN PIK3CD PIK3R2 MAPK9 STAT3 MAPK10 PPP2R1A RAB5A DKFZp434N101 MAP2K1 MAPK3 PTEN CBL ARHGAP35 YWHAQ HEL-S-1 HRAS NCK2 YWHAG YWHAZ ARAP1 DOK1 STAT1 USP6NL BRK1 RPS6KA3 KSR1 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY SAG RHO PDE6A LRAT GNB1 GNB5 SLC24A1 GUCY2D GNGT1 CNGA1 DKFZp686E1183 GNAT1 GUCA1C GUCY2F RPE65 GRK1 RDH12 RGS9BP PDE6G RDH5 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY CHUK NFKB1 DNAJC3 DKFZp686J04131 RELA EIF2AK2 EIF2S2 EIF2S1 NFKBIA BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY VEGFA FLT4 CALM3 CHRNA1 CALM2 BDKRB2 CHRM1 KNG1 ACTA1 RYR2 PDE3B FLT1 PDE2A SLC7A1 TNNI1 PRKAR1B PDE3A PRKAR1A PRKACG KDR BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY PPP3CA PPP3CC AP2M1 CALM3 CALM2 SYNJ1 NME2 EPN1 PICALM AP2A1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY KIAA0142 GRB7 ROCK2 PXN WASL MAP2K4 PAK1 BRAF SRC RRAS MAPK1 YES1 NCK1 RAP1A ITGAV ITGB5 RAPGEF1 PTPN21 TLN1 SH3GL1 CRK ARHGAP26 KLF8 BMX HEL114 CCND1 JUN ASAP1 MAPK9 MAPK8IP3 ACTA1 PIK3R1 ELMO1 FYN DKFZp434N101 RAC1 MAP2K1 ARHGEF28 MAPK8 ARHGAP35 MMP14 PIK3CA NCK2 ARHGEF11 GRB2 SOS1 ITGB1 GIT2 RAF1 DOCK1 ACTN1 DKFZp666O0110 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY TNKS IF2F XRCC5 TERF1 MAPK1 RBBP4 BLM NBN PINX1 SMG6 PARP2 hCG_37731 TINF2 DKC1 POT1 ATM TERF2IP IRF1 WRN FOS ACD MRE11A HUS1 PTGES3 ZNFX1 HNRNPC CCND1 RAD50 RAD9A NCL NR2F2 IFNAR2 JUN HDAC1 MAX WT1 TERF2 SP1 HEL2 MYC SP3 SMG5 SIN3B SIN3A TERT SAP30 MAPK3 TGFB1 SAP18 RBBP7 IL2 MTOR NFKB1 RPS6KB1 MXD1 EGF CDKN1B HDAC2 UBE3A EGFR PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY BIRC3 NFKBIA CHUK CD247 CRADD TRADD hCG_20684 TRAF2 FAS DKFZp686J04131 RELA TNFRSF1A RIPK1 TNFSF6 MAPK8 CASP6 NFKB1 BCL2 hCG_16983 CASP9 CASP3 BAG4 MAP3K5 FADD TRAF1 DFFB DFFA TNF-alpha CYCS APAF1 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY NFKB1 PIK3CA MAP2K2 CREB1 MAPK14 MAP2K3 SP1 RB1 MAP3K1 MAPK1 PIK3R1 RELA MAP2K6 MAP2K1 MAPK3 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY UBE2I SUMO1 RAN RANBP2 MDM2 PIAS1 HDAC1 HDAC4 PIAS2 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY PRNP DNAJB6 LAMA1 APLP1 RPSA LAMC1 GFAP BCL2 NFE2L2 HEL-S-89n DNAJB1 LAMB1 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 TRAF2 TANK TRAF1 DKFZp686J04131 RELA TRAF3 TNFRSF1B RIPK1 IKBKG IKBKAP PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY ADRBK1 MMP9 CXCL12 CD3G PXN CD3E HEL-S-15 CD3D MAPKAP1 MLST8 PAK1 RICTOR SRC CD247 BLK YES1 RALB CDC42 c-fgr ITGAV CRK FOXO1 STAT5B PAG1 UBQLN1 CSK RGS1 RHOB VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 STAT2 GNB1 ITGA4 PIK3R3 PIK3CD ITGA2 ITGA1 PIK3R2 BAD STAT3 LYN ARRB2 PIK3R1 ITGA7 FYN ITGA6 PRKCZ RAC1 hCG_2043376 GNAZ PTEN GNAI3 GNAI1 PTPN11 PDPK1 MTOR PIK3CA LCK PTK2B ITCH PTPRC GNAO1 ITGB1 PLCB3 CXCR4 PLCB1 HLA-DRA PLCB2 STAT1 VAV1 LIMK1 HGS DKFZp666O0110 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY GHR SHC1 GH1 PIK3R1 IGF1 IGF1R DKFZp564M2422 PIK3CA HRAS HEL-S-44 FOXO3A BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY WASF2 NTRK1 NCKAP1 ACTA1 HEL-S-276 NCK1 WASL WASF1 ABI2 PIR RAC1 WASF3 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 NR1I3 PTGS2 PTGS1 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY RBPJ NR1C2 CSNK2A1 JUN HDAC1 NOTCH1 MYC APC NEDD4 MAPK1 MAP3K7 MAPK3 CREBBP PP2150 PSEN1 NLK AXIN1 CTBP1 DVL1 FRAT1 FZD1 CSNK1A1 MAP3K7IP1 FOS CTNNB1 CCND1 HNF1A PSENEN LRP6 APH1B WIF1 PPP2R5D GSK3B DKK1 WNT1 DTX1 ADAM10 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY CRK CXCL12 NFKB1 PIK3CA PTK2B HRAS GNAQ MAPK1 CXCR4 PIK3R1 RAF1 RELA DKFZp434N101 PRKCB PIK3C2G MAP2K1 PRKCA MAPK3 BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY DKFZp434A091 BAAT PLD3 PLD2 CNR1 CNR2 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY BIRC3 CLTA NRAS CEBPA NCOR1 KRAS hCG_1991735 DKFZp586H0919 CEBPB CREBBP HES1 ADA CEBPD ELANE CDKN2A NLK KITLG KIT CCND1 SPI1 PPP3CA UBE2I CCNB1 LYZF1 LECT2 YEATS4 RAG2 PIM1 CD34 HEL-S-72p COPA PAX5 SND1 ADORA2B TFEC CBX4 PRTN3 SP1 MYC MAF MAD1L1 CSF1R HEL-S-11 DKFZp686J11229 H2AZ1 ETS2 ZFHX3 GSTM1 SIN3A ATP2B1 HIPK2 SKI MYF6 CDK6 MAP3K7 MYB ZFPM1 GATA1 CASP6 GATA3 HRAS MAP3K7IP1 BCL2 PTGS2 CDKN1A COL1A2 CDKN1B MPO TRIM28 EP300 WNT1 MYOD1 BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 RBBP4 HDAC2 BMI1 YY1 SUZ12 DKFZp686A1782 HDAC1 EED COMMD3-BMI1 CBX4 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNAI1 GNA14 MAPK8 GNA15 GNA11 JUN FOS MAPK14 GNAO1 PAK1 GNAQ MAPK1 IRS1 EDG5 RAC1 GNA13 MAPK3 GNAZ GNAI3 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY IL13 IL4 IL3 IL7 IL6 IF2F IL5 IL11 CSF1 PDGFA CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 IL8 TNF-alpha IL10 IF1DA1 IFNA1 IL15 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PIK3R1 PLCB1 PIK3CA VAV1 DKFZp434N101 PRKCB PRKCA BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY IGF1R PIK3CA HRAS GRB2 SOS1 BAD ADCY1 MAPK1 SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PRKAR1B MAP2K1 PRKAR1A MAPK3 PRKACG PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 IF2F CD3G CD3E CD3D JUN MAPK9 STAT3 PIAS2 CD247 IL18RAP PPP3R1 PRF1 TBX21 CREBBP TGFB1 MAPK8 IL2 IL2RA IRF1 STAT4 FOS IL18R1 CD80 ETV5 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY NFYA NFYB NFYC SP1 RB1 SP3 BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN DSPG3 KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGB4 ITGB8 ITGB7 ITGB6 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGA6 ITGAM ITGAV ITGAX ITGB5 ITGAE PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY KAT2B KAT2A TFDP1 NR1i1 IL5 RBL1 CREB1 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CEBPB CREBBP ITGB5 FOXO4 NR3C1 FOXO1 NR2A1 CDK2 FOS ATF3 RUNX2 NCOA1 HEL-S-72p JUN HDAC1 MAX GSC SP1 MYC CBFB SP3 SIN3B SIN3A SKI SKIL SAP30 FOXO3A SMAD2 SMAD4 SAP18 RBBP7 CITED1 LAMC1 MED15 CTBP1 SNIP1 TGIF1 GATA3 TGIF2 FOXH1 RUNX3 DLX1 FOXG1 CDKN2B DCP1A ATF2 CDKN1A COL1A2 NKX2-5 SERPINE1 MEF2C HDAC2 CDK4 EP300 IL10 IF1DA1 TCF3 MYOD1 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY NQO1 HIC1 MAPK8 FHL2 ATM RPA1 GADD45A NFKBIB TAF1 DNAJB1 CDKN1A BAX ABCB1 HIF1A MDM2 EP300 BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40LG HLA-DRB5 HLA-DRB4 HLA-DRA FAS HLA-DRB3 HLA-DRB1 TNFSF6 CD40 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNB1 SMO HDAC1 RBBP4 ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D SAP30 CSNK1G2 MAP2K1 CSNK1G1 CREBBP GNAZ GNAI3 GNAI1 SAP18 RBBP7 CSNK1A1 CSNK1E PIAS1 SHH PTCH1 GNAO1 IFT172 GLI3 KIF3A SUFU RAB23 HDAC2 SPOP MTSS1 FOXA2 GSK3B hCG_22119 GNG2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 IL4 PPP5C IL6 IF2F TSG101 IL5 CREB1 SMARCD1 SMARCC1 SMARCC2 SGK1 MAPK1 TBP BAX MAPK11 KRT5 CSF2 CREBBP KRT14 PRKACG NR3C1 POU2F1 STAT5B SELE IRF1 FOS NR1I3 POMC SPI1 NFATC1 SUMO2 SFN NCOA1 PRL JUN HDAC1 BGLAP MAPK9 MAPK14 SMARCA4 MAPK10 TBX21 RELA MDM2 MAPK3 MAPK8 IL2 NFKB1 GATA3 CDK5 CDK5R1 CDKN1A HDAC2 STAT1 CSN2 POU1F1 FKBP4 IL8 GSK3B FKBP5 EP300 CGA PCK2 PBX1 AFP BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY CDKN2A SKP2 CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CCND1 CDKN1A CDKN1B CDK6 GSK3B CDK4 ATR SMAD4 TGFB1 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY WASF2 CYBA CYFIP2 ARPC1B NOXA1 NCKAP1 ACTR3 ACTR2 IQGAP3 PIP5K1A HEL-S-15 HEL-S-47e JUN MAPK9 MAPK14 MAP2K3 MAP2K4 PAK1 STAT3 MAP3K1 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 CTNNA1 WASF1 PIP5K1C hCG_1991735 MAP2K6 RAC1 CRK MAPK8 ARHGAP5 MAP3K11 CTNNB1 ATF2 STM7 PLCB2 ABI2 BRK1 LIMK1 NCF1 NCF2 CYBB BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY HOXA7 JUN PRKCE MAPK14 MAPK13 IKBKB MAP2K3 MAP2K4 NFKBIA SP1 MAP3K1 CEBPA CHUK MAPK1 ETS2 TRAF2 FAS PPP2CA DKFZp686J04131 RELA TNFRSF1A RIPK1 TNFSF6 MAP2K6 MAP2K1 MAPK3 MAPK8 NFKB1 PRKCH HRAS BCL2 FOS EGF PRKCQ MAP3K5 RAF1 TNFRSF1B TNF-alpha PRKCB PRKCA EGFR BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 NCOR2 GRIP1 MED1 HDAC3 SRA1 PHB2 SPEN HDAC1 HDAC4 PPARGC1A DKFZp566E044 HDAC5 CCND1 GTF2A1 CARM1 TBP HDAC2 MEF2C BRCA1 PELP1 EP300 CREBBP BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY PRKAG1 EDG2 LPAR3 EDG4 PRKACG PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAP2K5 EGR1 MAP3K2 RPS6KA5 CREB1 MAPK14 MAP2K3 NRAS BRAF MAPK1 TRPV1 RAP1A KRAS MAP2K6 MAP2K1 MAPK3 CDK5 HRAS FOS CDK5R1 NTF3 RAF1 MEF2C RPS6KA1 RIT1 RIT2 MAPK7 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY CD247 IF2F CD3G CD3E CD3D TYK2 STAT4 NOS2 CXCR3 CCR5 CD2 IL12RB1 PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY MMP9 EDG2 LPAR3 IL6 EDG4 TIAM1 ADCY9 PXN PRKCE ADCY3 SLC9A3R2 LPAR4 ADCY1 ADCY8 ADCY6 SRC CRK FOS GNA13 GNG2 PLD2 GNB1 ARHGEF1 JUN NFKBIA LYN PIK3R1 PRKD1 TRIP6 RELA DKFZp434N101 RAC1 HBEGF GNAZ GNAI3 GNAI1 GNA14 GNA15 NFKB1 GNA11 PTK2B HRAS GNAO1 MMP2 PLCB3 GNAQ CASP3 IL8 GSK3B ADRA1B DKFZp666O0110 EGFR PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY TAOK3 TAOK1 ATM MAP3K7IP1 TAOK2 GADD45A MAPK14 MAP2K3 MAP3K1 MAP3K6 TXN MAP3K10 MAP3K5 TRAF2 GADD45B MAPK11 GADD45G TRAF6 MAP3K7 MAP2K6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPC3 KCNQ3 GNAS KCNQ5 GUCY1A2 TRPC5 GUCY1B1 TRPC4 ADCY1 TRPV4 KCNQ2 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF5 DKFZp781H1925 EIF2AK1 EIF2B5 EIF2AK4 EIF2AK2 GSK3B EIF2S2 EIF2S1 EIF2S3 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC3 AIFM1 CASP6 BAK1 BCL2 hCG_16983 DIABLO CASP9 CASP3 BAX BIK DFFB DFFA APAF1 BIRC2 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY IF2F SOCS3 SOCS1 JUN SYK PRKCE MAPK9 MAPK14 NRAS MYC STAT3 MAPK1 SHC1 PIK3R1 IL2RG FYN SOCS2 MAPK11 STAM2 KRAS MAP2K1 CISH JAK3 MAPK3 JAK1 PTPN11 GAB2 MAPK8 IL2 PIK3CA PTK2B STAT5B LCK CDK2 IL2RA HRAS MAP2K2 IL2RB BCL2 FOS GRB2 SOS1 RAF1 STAT1 PPP2R5D IRS1 IKZF3 PRKCB PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY ROCK1 ROCK2 PLD2 PIP5K1A HEL-S-15 JUN DKFZp686M02159 MAP2K3 MAP2K4 LIMK2 ACTA1 PRKCZ CDC42 PARD6A PIP5K1C SCAI MAP2K6 HEL70 RDX MRTFA CIT PKN2 PTEN MYL2 TLN1 MAPK8 EZR F2RL2 PKN1 FOS SLC9A3 ITGB1 ATF2 HEL114 CDKN1B STM7 CYR61 LIMK1 DKFZp686B23205 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 UBE2D3 CCNE1 CSTF1 RBBP8 NBN BARD1 RAD51 EWSR1 FANCL CDK2 ATM FANCA MRE11A FANCC PRKDC FANCE FANCG FANCF RAD50 FANCD2 PCNA BRCA1 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY FANCG FANCF FANCD2 BRCA1 FANCA FANCC BARD1 FANCE BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY PPP3CA F2 CAMK1 PPP3CC CAMK1G CALM3 CALM2 MAPK14 CAMK4 NFATC4 MAPK1 ACTA1 PIK3R1 NPPA PRKAR1B MAP2K1 PRKAR1A MAPK3 CREBBP HBEGF PRKACG CTF1 HEL-S-99n MAPK8 MYH2 IGF1 HAND2 HAND1 RPS6KB1 PIK3CA CSNK1A1 HRAS EDN1 GATA4 NKX2-5 NFATC3 RAF1 MEF2C FGF2 GSK3B NFATC2 NFATC1 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY NF1 TACI SDC2 ITGA2 SRC MAPK1 EPHB2 BAX CSF2 MAPK3 TGFB1 MAPK8 EZR CAV2 TRAPPC4 HRAS MMP2 ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP IL8 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY P2RY2 PTK2B DKFZp434N101 PRKCB PRKCA BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB DFFA TOP2A HMGB2 HMGB1 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY JUN MAP2K4 PAK1 MAP3K1 CRADD TRADD hCG_20684 TRAF2 TNFRSF1A RIPK1 MAP3K7 MAPK8 hCG_16983 PRKDC RB1 LMNB2 CASP3 BAG4 ARHGDIB FADD LMNA DFFB DFFA TNF-alpha PARP1 MADD BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY RAN RCC1 KIF15 HCTP4 KPNA2 RANBP1 NUMA1 AURKA PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 IKBKG TRAF6 NSMCE3 OMG RTN4R MAGEH1 BEX3 ZNF274 BEX1 PSENEN RTN4 NDN SORT1 FURIN RHOB APH1B RIPK2 MAPK9 IKBKB BAD HEL2 ADAM17 IRAK1 MAPK10 SHC1 PIK3R1 PRKCZ MYD88 RAC1 hCG_2043376 PSEN1 MAPK8 CASP6 PRKCI PIK3CA APP DIABLO CASP9 MAGED1 NTF5 SMPD2 CASP3 NTF3 PLG MMP7 BDNF MMP3 SQSTM1 CYCS APAF1 BIRC2 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY IL18 VCAM1 MAP2K2 MAP2K3 MAP2K4 MAPK1 PGR ANTXR2 ANTXR1 NLRP1 IL1B DEFA1B TNF-alpha MAP2K6 MAP2K1 MAPK3 PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY CTNND1 WASF2 CYFIP2 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 CSNK2B SRC PIK3R1 CDC42 RAP1A CTNNA1 PIP5K1C ARF6 hCG_1991735 RAC1 VAV2 JUP AFDN RAPGEF1 ITGAE CRK ITGB7 DKFZp686A1195 PIK3CA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY HLA-DRB5 HLA-DRB4 IL4 CCL11 HLA-DRA IL6 HLA-DRB3 IL1B HLA-DRB1 IL5 CCR3 IL5RA PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY MMP9 GPLD1 SRC ITGB3 VTN ITGAM ITGAV RAC1 ITGB5 TGFB1 CRK ELANE PLAUR VLDLR ITGB1 FGA SERPINE1 PLG HGF HEL-S-78p FPR1 KLK4 PDGFD MMP3 NCL CTSG DOCK1 FPRL1 FPRL2 MMP12 EGFR CTRC BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IF2F JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY CAMKK2 ROCK1 PXN ARF1 MAP2K3 BRAF SRC ITGB3 MAPK1 CDC42 NCK1 CTNNA1 MAPK11 FLT1 ITGAV hCG_1991735 MAP2K6 KDR FES HEL114 PTPN6 PRKAB1 PRKCB PRKCA HSP90AB1 MYOF VEGFA MAPK14 NEDD4 PRKAG1 GRB10 PIK3R1 VTN FYN DKFZp434N101 MAP2K1 MAPK3 SHB PTPN11 PDPK1 CBL PIK3CA PTK2B MAP2K2 NCK2 PRKAA1 GRB2 PRKAA2 CTNNB1 RAF1 HGS DKFZp666O0110 SH2D2A PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY PLAUR MAPK1 RAB11FIP3 RAB11A TIAM1 PLD2 PIP5K1A ARF6 KALRN ARF1 RAC1 MAPK3 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY UBE2D1 ERBB3 NRG1 EGF EGFR BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG RPS6KA1 KIT CREB1 MITF-C BCL2 EP300 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY THRA ZBTB16 NCOR2 RARA RXRA MAPK14 MAP2K1 EGF MAP3K1 THRB EGFR BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 AXIN1 NFKB1 DVL1 LBP PIK3CA FZD1 EIF2AK2 CTNNB1 APC CCND1 PIK3R1 PPP2CA RELA MYD88 GSK3B CXNK2 WNT1 DKFZp586H0919 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 HTATIP DVL1 LDB1 FZD1 MED1 HDAC1 CTNNB1 APC TRRAP GSK3B EP300 WNT1 CREBBP DKFZp586H0919 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY IL3 KITLG IL6 CD3G CD58 CD34 CD3E CD3D IL17A CD2 CD247 CSF3 IL8 CD8A BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY PPP3CA CAMK1 PPP3CC CAMK1G CALM3 CALM2 MAPK14 MAP2K3 NFKBIA PAK1 MAP3K1 NFATC4 MAPK1 RELA MAP2K6 RAC1 MAP2K1 MAPK3 GNA15 NFKB1 HRAS MAP2K2 NFATC3 RAF1 PLCB1 FPR1 PIK3C2G NFATC2 NCF1 NCF2 NFATC1 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY RBPJ PSEN1 AXIN1 DVL1 DKFZp781N011 FZD1 NOTCH1 CTNNB1 ADAM17 HNF1A APC GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 HLA-DRB4 IL3 CCL11 HLA-DRA HLA-DRB3 HLA-DRB1 IL5 CCR3 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY NRP1 VEGFA FLT4 VEGFB VEGFC VEGFD DKFZp686J1169 FLT1 KDR BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY NR3C1 HSD11B1 RXRA TNF-alpha RETN LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY CCNB1 PIN1 CDC2 HRAS CAP1 PAQR7 PAQR5 ADCY1 MYT1 MAPK1 ACTA1 PGR RPS6KA1 PRKAR1B PRKAR1A MAPK3 PRKACG BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY RPS6KB1 PIK3CA CDK5 PAK1 CDK5R1 MAP3K1 PPP1R12B PIK3R1 VAV1 WASF1 LIMK1 CHN1 RAC1 PDGFRA RALBP1 TRIO NCF2 MYL2 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A4 MMP9 COL4A3 COL4A6 COL4A5 hEMMPRIN HPSE COL1A1 PPIB MAPK1 SDC1 MAPK3 COL17A1 LAMA5 COL16A1 TGFB1 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL3A1 COL9A3 COL1A2 COL9A2 CASK HGF SDCBP MMP7 CCL5 COL4A1 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP3 ARHGAP5 ARHGDIB PRF1 CASP10 JUN PARP1 hCG_16983 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP IL6 SOCS3 MITF-C JUN TNFSF11 MAPK14 LMO4 MAP2K4 MYC STAT3 CRP HEL-S-125m A2M PIK3R1 PTPRE MAPK11 MAP2K6 RAC1 MCL1 CEBPB JAK1 CEBPD PTPN11 GAB2 FOXO1 TIMP1 PIK3CA IL6ST IL6R PIAS1 TYK2 IRF1 FOS GRB2 SOS1 BCL2L1 JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY VLDLR FYN LRP8 RELN DAB1 CDK5 CDK5R1 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY HTATIP CCNA2 IL6 IF2F CREB1 TH MAPK1 DUSP8 MAPK11 DUSP10 HES1 POU2F1 SELE FOS CCND1 JUNB JUND NOS2 PRKCA ATF3 ARG1 NF1 INS SOCS3 JUN MAPK9 GADD45A MAPK14 PPARGC1A CBFB HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 MAPK8 DUSP5 BCL2 MMP2 BCL2L1 RB1 ATF2 BRCA1 DDIT3 IL8 CDK4 EP300 IL23A RUVBL2 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY MAP2 PRKAG1 CDC2 PPP2CA PRKCE PKN1 NUP85 AKAP9 PCNT PRKACG PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY PPP3CA CHP1 RAN SFN MEF2D NUP214 PIM1 CSNK2A1 PRKCE MAPK9 KPNA2 MAPK14 BAD RCAN1 HEL2 MAP3K8 CAMK4 MAP3K1 PPP3R1 PRKCZ MAPK3 CREBBP MAPK8 YWHAQ HEL-S-1 PRKCH CSNK1A1 FKBP1A BCL2 YWHAG BCL2L1 YWHAZ CASP3 NFATC3 PRKCQ GSK3B EP300 PRKCB NFATC2 PRKCA NFATC1 AKAP5 CABIN1 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG RAPSN PIK3R1 PIK3CA PTK2B TERT TNFSF6 FOXO3A BAD CHRNB1 MUSK PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY RBPJ SKP2 MAML2 IL4 KDM1A MARK2 ADAM12 MAML1 RAB11A NCOR2 HDAC1 SPEN NOTCH1 MYC RBBP8 NCOR1 PSEN1 NOTCH3 MYCBP CBL CTBP1 DLL3 DLL4 GATA3 DNER JAG2 MIB1 MFAP5 ITCH MFAP2 LNX1 CNTN1 CCND1 CDKN1A SKP1 PSENEN FURIN HEL-S-17 YY1 APH1B DKFZp434N181 EP300 FBXW7 DTX1 ADAM10 NUMB PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY NUP214 SMAD9 PPP1R15A MAPK1 SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CTDSP1 CTDSP2 CTDSPL ZFYVE16 BAMBI BMPR2 CHRDL1 SOSTDC1 CER1 DKFZp781O1323 AHSG FST HFE2 SMAD1 RGMB BMP6 RGMA NOG GREM1 SMAD6 BMP7 GSK3B BMP4 BMP2 BMPR1A PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY EGR4 EGR1 IF1AA9 IF1AA8 IF1AB4 IF1AB1 IF2F CD3G CD3E CD3D PRKCE NRAS BRAF CD247 MAPK1 KRAS TNFRSF9 CD8B1 FOS STAT4 NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA IFNAR2 JUN IFNAR1 MAPK9 PPP3R1 IL2RG PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 MAPK8 IL2 IL2RA HRAS MAP2K2 IL2RB PRKCQ RAF1 IFNA4 TNFRSF4 TNF-alpha IFNA14 TNFRSF18 IF1AA3 IF1AA1 IF1AA6 IFNA1 IF1AA5 CD8A IF1AA4 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY F2 F10 SERPINC1 TFPI F3 HEL-S-78p F5 PROC F2R PROS1 F7 FGA PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY INS LEP YBX1 SOCS3 PRL PRLR STAT3 CSF1R CSF1 SRC LYN BLK ITGB3 SHC1 YES1 LAT PIK3R1 FYN Pe1Fe6 LEPR c-fgr CDH2 PTPN1 INSR CRK PIK3CA STAT5B LCK TYK2 GRB2 TRPV6 EGF CSK TXN ITGA2B DOK1 CSN2 SPRY2 FCGR2A IRS1 EGFR BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY EPO IL2 IL4 IL3 IL7 IL6 IL5 IL9 IL11 CSF1 CSF3 IL8 CSF2 CD8A PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY EGR4 EGR1 BATF3 IRF4 IL4 IL3 IF2F IL5 DGKA SLC3A2 JUN PTPRK IKZF1 PPARG GBP3 EGR2 RNF128 MAF CD40LG TBX21 FOXP3 CSF2 TNFSF6 CTLA4 PTPN1 FOSL1 IL2 POU2F1 GATA3 IL2RA ITCH FOS PTGS2 CASP3 NFATC3 PRKCQ JUNB IL8 TNF-alpha CDK4 NFATC2 NFATC1 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY CAMK1 CAMK1G MYOD1 HDAC9 PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY VEGFA INS PIK3R3 EIF2AK2 PIK3CD STAT6 PIK3R2 ITGA1 KPNA2 LMAN1 STAT3 CSF1R CSF1 SRC SHC1 PIK3R1 PTPN1 JAK3 CREBBP INSR JAK1 KDR RAB4A PIK3CA STAT5B PIAS1 GRB2 SOS1 ITGB1 EGF STAT1 HGF ATR EGFR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK1 PELP1 EP300 CREBBP MAPK3 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 FCGR2B PTPRC CD40 CR2 BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY PCLO ACTA1 DLG2 CASK GUK1 NRXN3 NCAM1 ADD1 SPTBN1 GRIN1 DLG4 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAPK8 ROCK1 MAP2K2 HRAS MAP4K2 MAP3K1 HNF1A MAPK1 ACTA1 RAF1 CDC42 MAL LIMK1 RAC1 MAP2K1 MAPK3 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY STAT1 SOCS3 STAT5B TYK2 JAK3 STAT3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CSNK1E PER1 CRY2 CRY1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY IL1A VCAM1 CD34 IL8 ITGA4 MADCAM1 SELL PECAM1 ICAM2 ITGB1 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 LYN BTK SHC1 PIK3R1 PLCG2 RAP1A SH2B3 TEC DKFZp434N101 VAV2 RAPGEF1 CRKL EPO PTPN11 EPOR MAPK8 CBL NFKB1 STAT5B HRAS TRPC6 BCL2 GRB2 SOS1 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY GLI3 SUFU GSK3B SMO SHH PRKAR1B DYRK1A PRKAR1A PTCH1 DYRK1B PRKACG PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY PIN1 SKP2 HTATIP CCNA2 KAT2B RFWD2 CCNG1 CSNK1G3 CSNK1D CSNK1G2 CHEK1 CSNK1G1 RPL5 CREBBP DYRK2 SETD8 SETD7 TP53AIP1 CDKN2A RASSF1 PPP1R13L KAT8 RPL23 FBXO11 PPM1D CDK2 CSNK1E PTPA CSNK1A1 ATM SMYD2 E4F1 MDM4 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 PPP2CA HIPK2 MDM2 HUWE1 MAPK8 YY1 GSK3B TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY PTPN11 MAPK8 SLC2A4 PIK3CA CSNK2A1 JUN HRAS FOS GRB2 SOS1 SHC1 PIK3R1 RAF1 IRS1 MAP2K1 INSR MAPK3 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC3 CLTC PIK3R3 PIK3CD SYK PIK3R2 MAPK9 MAPK14 IKBKB MAP3K1 SRC CHUK BTK MAPK10 PIK3R1 FAS MAPK11 RIPK1 SMPD1 IKBKG TNFSF6 MAP2K6 PDPK1 MAPK8 EZR CASP10 PIK3CA hCG_16983 FAIM2 CASP3 FADD RFC1 BIRC2 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY UBE2I UBA2 SAE1 FBXO2 EDEM1 SEC61A1 HEL-S-164nA SKP1 MAN2A2 CANX GCS1 MAN1A2 UGGT1 MAN1A1 MAN2C1 RBX1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EIF6 EIF4E EIF1AX EIF2S2 EIF2S1 EIF4A2 SUI1 EIF2S3 AAG1 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY DAPP1 BLNK MAP3K1 CHUK BTK MAPK1 PLCG2 IKBKG TRAF6 POU2F2 VAV2 FLJ00120 PAG1 FOS CSK CD19 SH3BP5 CD72 IBTK PTPN6 CD22 NFATC1 PPP3CA PPP3CC CSNK2A1 SYK JUN MAPK14 IKBKB BCL10 NFKBIA LYN SHC1 PIK3R1 RELA MAP3K7 CAMK2G RAC1 CD79B MAP2K1 CD79A MAPK3 PTEN PDPK1 MAPK8 NFKB1 PIK3CA HRAS PTPRC GRB2 SOS1 NFKBIB RAF1 DOK1 BCL2A1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY MMP9 ROCK2 GNB1 GNAL NRAS SRC SHC1 PIK3R1 PELP1 MAPK11 KRAS HEL70 ESR2 HBEGF GNAZ GNAI3 GNAI1 GNA14 GNA15 IGF1R GNA11 PIK3CA HRAS GRB2 GNAO1 SOS1 MMP2 PLCB3 GNAQ PLCB1 PLCB2 STRN GNA13 GNG2 BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F2 COL4A4 SERPINC1 COL4A3 COL4A6 COL4A5 F11 F5 F9 F2R KNG1 FGA F10 HEL-S-78p PROC PROS1 F8 COL4A2 KLKB1 COL4A1 PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 PLAUR ITGB7 ITGB6 VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 CYR61 ITGAV MADCAM1 FBN1 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY LIN7A IFNGR1 TAX1BP3 IFNGR2 NFKB1 IF2F IKBKB WT1 NFKBIA RB1 RELA TNFRSF1B TNFRSF1A TNF-alpha USH1C BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY CSK LRRTM2 CTNNA3 CTNNA2 CTNNA1 PECAM1 ACTN1 CTNNB1 HEL114 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY SKP1 CDC34 TFDP1 CDK2 CCNE1 FBXW7 RB1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA2 GABRA6 PRKCE HEL-S-44 GPX1 GABRA5 GABRA4 GABRA3 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY GNAI1 S1PR1 VEGFA GNAO1 PTGS2 ITGB3 MAPK1 ABCC1 PLCB2 ITGAV DKFZp434N101 RAC1 MAPK3 GNAZ SPHK1 GNAI3 KDR BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RCC1 RANBP1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY SKP1 CDC34 SKP2 TFDP1 CDK2 CCNE1 RB1 BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 PTK2B CREB1 HRAS GRB2 SOS1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY PPP3CA PPP3CC CALM3 CALM2 JUN SYK MAPK14 MAP3K1 LYN NFATC4 BTK SHC1 DKFZp434N101 CD79B RAC1 CD79A MAP2K1 MAPK3 MAPK8 HRAS FOS GRB2 SOS1 NFATC3 RAF1 VAV1 PRKCB NFATC2 PRKCA NFATC1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY EIF4EBP1 GDI1 RPS6KA5 USF1 CSNK2A1 KRT19 MITF-C JUN CREB1 CSNK2A2 ATF1 MAPK14 PPARGC1A CSNK2B RAB5A MAPK11 EIF4E CEBPB PTGS2 ATF2 MKNK1 HEL-S-102 MEF2C DDIT3 MAPKAPK5 RPS6KA4 NOS2 MAPKAPK3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY VCAM1 C6 IL6 C7 ITGA4 ITGB1 KNG1 SELP IL1A HEL-S-62p SELPLG IL8 TNF-alpha BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY GNAQ PLCB1 TUB CHRM1 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY CHRNA1 JUN DAG1 DMD PAK4 AGRN SP1 PAK1 MAPK1 ACTA1 CDC42 NRG1 NRG2 NRG3 RAC1 MAPK3 MUSK LAMA4 RAPSN MAPK8 DVL1 CHRM1 ITGB1 GIT2 LAMA3 EGFR PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PXN JUN CREB1 PDLIM7 DOK4 DOK5 SRC DOK6 MAPK1 SHC1 PIK3R1 GRB10 RAP1A NCK1 RAC1 MAPK3 PTPN11 CRK MAPK8 PIK3CA HRAS GRB2 FRS2 SOS1 RET DOK1 IRS1 DKFZp666O0110 PRKCA GDNF BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY PPP3CA PPP3CC CALM3 CALM2 JUN CREB1 HRAS FOS ADCY1 NFATC4 GNAQ NFATC3 RAF1 DKFZp434N101 PRKCB PRKAR1B MAP2K1 NFATC2 RPS6KA3 PRKAR1A PRKCA MAPK3 NFATC1 PRKACG PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY SPP1 VCAM1 PXN ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 ARF6 RAC1 PRKAR1B PRKAR1A JAM2 TLN1 CRK CD14 MYH2 PTK2B ITGB1 YWHAZ THBS1 MDK DOCK1 PTPRA DKFZp666O0110 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY CASP6 ATM BCL2 BAD CASP9 CASP3 BAX STAT1 PARP1 PRKCB EIF2S1 PRKCA APAF1 TLN1 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY F2 F2RL3 SYK F2R HRAS ITGB1 PTGS1 TBXAS1 MAPK1 RAF1 PLCB1 PRKCB MAP2K1 PRKCA MAPK3 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY CSK CCNB1 DKFZp686G14213 CDC2 VPS16 PRKCB GRB2 PTPRA PRKCA PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 VEGFA APEX1 SP1 SLC11A2 FLT1 POU5F1 ADORA2A EIF3E EGLN2 FXN CREBBP KDR EPO TCEB1 CITED2 VHL HIF1AN MMP14 HEL-S-68p ABCG2 BHLHB2 SERPINE1 TWIST1 EP300 EGLN1 EGLN3 EFNA1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY TIAM1 EFNB2 EFNB1 MAP2K4 SRC LYN BLK ITGB3 EPHB2 YES1 PIK3R1 EPHB1 FYN EPHB4 c-fgr MAP3K7 RAC1 MAPK8 PIK3CA LCK PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC3 IL4 JUN MAPK9 MAPK14 CD40 MAP2K4 NFKBIA MYC MAP3K1 CD40LG MAPK10 TRAF2 DKFZp686J04131 RELA TRAF3 MAPK11 TRAF6 C4BPA JAK3 FCAMR MAPK8 NFKB1 BCL2L1 TNFAIP3 TRAF1 BIRC2 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY EIF4EBP1 PXN MAPKAP1 CCNE1 MLST8 NRAS PML RICTOR BRAF RB1CC1 SGK1 MAPK1 KRAS CDK2 EEF2K RPS6KA1 TSC2 IRS1 DDIT4 PRKCA BNIP3 EIF4A1 SFN PLD2 IKBKB PPARGC1A HEL2 TSC1 RHEB EIF4E RAC1 MAP2K1 MAPK3 hCG_2039433 DKFZp434G0310 RRAGA PDPK1 RRAGB RRAGD ULK2 MTOR ULK1 RRN3 RPS6KB1 YWHAQ EIF4B HEL-S-1 HRAS MAP2K2 YWHAG YWHAZ RAF1 YY1 raptor DEPTOR AKT1S1 CYCS BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY NCOR2 NCOA1 SRA1 MED1 RXRA JUN LPL PPARGC1A NFKBIA SP1 MYC MAPK1 PIK3R1 NCOR1 PDGFA RELA ME1 PRKAR1B PRKAR1A MAPK3 CREBBP PRKACG NR1C1 CITED2 PIK3CA MRPL11 STAT5B DUT APOA2 FABP1 ACOX1 EHHADH PTGS2 APOA1 RB1 TNF-alpha EP300 PRKCB NOS2 PRKCA NR0B2 BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A HEL-S-62p C6 C7 C9 CFD CFP PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 PIN1 HTATIP CCNA2 BAK1 CCNE2 GDF15 PML NTRK1 hCG_20684 BAX FAS BCL2L11 MAPK11 BRCA2 CHEK1 FASN RAD51 ADA CLCA2 TP53AIP1 FLOT2 CDC2 AEN CDK2 TP73 TUBA1A PLK1 TP63 S100A2 SERPINA1 CCNB1 SFN PLK3 HEY2 WWOX MAPK14 WT1 SP1 MYC DKFZp451O0517 BIN1 TP53I3 RELA MDM2 CDK6 FOXO3A JAK1 GATA1 BBC3 JAG2 ITCH RNF43 RB1 UBE4B CDKN1A HAGH PFDN5 FBXO45 GRAMD4 SERPINE1 HSF1 DEDD PPAP2A D4S234E DCP1B EP300 AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY AXIN1 DKFZp586M1622 DVL1 DVL2 GSK3A FZD5 WNT3A CTNNB1 APC STM7 LRP6 KLHL12 GSK3B NKD2 PI4K2A CSNK1G1 PPP2R5A PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY SOCS1 MITF-C BAD STAT3 LYN SHC1 PIK3R1 GRB10 Pe1Fe6 SNAI2 SH2B3 TEC FOXO3A MAP2K1 GRAP2 MAPK3 CREBBP PTEN CRKL EPO PTPN11 EPOR PDPK1 MAPK8 CBL KITLG RPS6KB1 PIK3CA KIT HRAS MAP2K2 BCL2 MATK GRB2 SOS1 RAF1 STAT1 DOK1 VAV1 PTPN6 GSK3B MAP4K1 PTPRO SH2B2 PIK3C2B SPRED1 BRDG1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CSF1 IL1B TNF-alpha CCL2 PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY ZFYVE28 CHMP3 KIAA0142 AMPH UBE2D1 STAMBP TSG101 ITSN1 PIK3R3 PIK3CD UBE2D3 PIK3R2 LRIG1 NRAS SRC SHC1 PIK3R1 CDC42 RAB5A SYNJ1 KRAS EPN1 CBL PIK3CA HRAS GRB2 SOS1 EGF RAF1 SPRY2 HGS DKFZp666O0110 UBE2D2 EGFR DKFZp686B23205 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK1 NTRK1 SHC1 PIK3R1 RPS6KA1 PIK3CA CREB1 HRAS DKFZp434N101 GRB2 MAPK7 MAPK3 BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY CTNND1 MMP9 SPP1 FGF4B FGF6B RUNX2 FGFR1 SDC2 FGF6A FGF8 FGF8A FGF23 JUN BGLAP FGFR4 PAK4 FGFR3 FGFR2 SRC CAMK2A MAPK1 SHC1 PIK3R1 NCAM1 CDH2 DKFZp434N101 MAPK3 PTPN11 PDPK1 PLAUR CBL PIK3CA PTK2B STAT5B FGF7A FOS GRB2 FRS2 SOS1 RPS6KA1 STAT1 HGF FGF2 SPRY2 SSH1 FGF7B BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY BIRC3 NFKB1 CASP6 TNFSF10 CASP10 BCL2 hCG_16983 NFKBIA TNFRSF25 CHUK CASP9 TRADD CASP3 TRAF2 FADD LMNA DKFZp686J04131 RELA DFFB DFFA RIPK1 GAS2 APAF1 BIRC2 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY NFYA RBL1 NFYB CREB1 NFYC GFI1 CLU FTH1 CEBPA SLC11A1 TBP SFRP1 TMEFF2 CSDE1 TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 SFXN3 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 SPI1 DKK1 ID2 HDAC3 HDAC1 MAX GADD45A SP1 MYC DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 ERBB2 BCL2 CDKN2B ITGB1 CDKN1A COL1A2 CDKN1B BRCA1 DDIT3 EP300 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2A CCNB1 CDC2 TFDP1 CDK2 RBL1 CDK7 CCNH CCNE1 CDKN2B CDKN2D RB1 CCND1 CDKN1A CDKN1B CCND2 CCND3 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY CBL PRKCB GRB2 SH3GLB1 PDGFRA SH3GLB2 PRKCA EGF CSF1R EGFR BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY NR3C1 NFKB1 TGFBR1 TGFBR2 MAPK14 MAP2K3 IKBKB NFKBIA CHUK DKFZp686J04131 RELA IL1B MAPK11 IL8 MYD88 TNF-alpha MAP3K7 EP300 MAP2K6 CREBBP SMAD4 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY COL4A4 COL4A3 COL4A6 SPP1 COL4A5 ITGAV NPNT NID1 JAM2 CSPG4 PLAUR COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA HEL-S-45 ITGA4 ITGA2 ITGA1 COL1A1 IGSF8 CD81 THBS2 VTN ITGA7 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 LAMB2 ITGB1 LAMB1 COL3A1 LAMA1 COL1A2 LAMA3 TNC THBS1 MDK COL4A1 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY IL13 IL4 GATA3 IL5 PRKAR1B MAPK14 MAP2K3 PRKAR1A NFATC2 PRKACG NFATC1 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY FOXO4 NFKB1 PIK3CA HRAS BAD CHUK CASP9 PIK3R1 RAF1 CDC42 RELA RAC1 MAP2K1 RALBP1 MAPK3 RALA BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY PTPN11 MAPK8 IGF1 IGF1R PIK3CA CSNK2A1 JUN HRAS FOS GRB2 SOS1 SHC1 PIK3R1 RAF1 IRS1 MAP2K1 MAPK3 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY CALM3 CALM2 JUN MAPK14 MAP2K3 MAP2K4 PAK1 MAP3K1 MAPK1 SHC1 DKFZp434N101 RAC1 MAP2K1 MAPK3 CRKL MAPK8 PTK2B HRAS MAP2K2 GRB2 SOS1 GNAQ RAF1 PRKCB PRKCA PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY UBE2I RANBP9 KDM1A NKX3-1 XRCC5 PAWR MED1 CARM1 PELP1 UBA3 CDK6 TMPRSS2 KLK3 KDM3A CDKN2A TMF1 TGFB1I1 FHL2 ZMIZ1 HNRPA1 APPL1 TGIF1 PTK2B SVIL KDM4C NCOA6 PIAS1 CTDSP1 PA2G4 CTDSP2 hCG_16983 VAV3 hCG_2042738 LATS2 MAK CTNNB1 PRKDC ZNF318 CCND1 CMTM2 ZNF278 BRCA1 TCF4 CCND3 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY MAPK8 CALM3 CALM2 PTK2B JUN MAP2K2 HRAS GRB2 SOS1 MAP2K4 PAK1 ATF2 MAP3K1 GNAQ MAPK1 SHC1 AGTR1 RAF1 PRKCB RAC1 MAP2K1 PRKCA MAPK3 EGFR BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY MAPK8 CXCL12 CCL4 CALM3 CALM2 PTK2B JUN FOS MAPK14 CCR5 GNAQ CXCR4 DKFZp434N101 PRKCB CCL2 PRKCA BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPO EPOR NFKB1 DKFZp564M2422 HIF1A RELA NFKBIA GRIN1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 TGFB1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC IRS1 PRKACA SHC1 PIK3CA PXN JUN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 RASA1 MAPK8 GRB2 SOS1 SHANK3 MAPK1 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 TGFB1 COL5A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 AKT1 IL4R ARG1 GTF3A IL10 OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 MTOR CEBPB AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 SHC1 PIK3CA BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 HSP90AA1 IL2 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 JAK3 MYC JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 BDNF PIK3R1 NOS3 EGF NTRK3 IGF1 VEGFA NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D CDKN1B AR NOTCH1 KDM1A JAK2 MAML2 MAML1 GATA6 NCOR1 TWIST1 MYOD1 GATA4 STAT3 ASCL1 RBPJ GATA1 HIF1A GHR HDAC1 YY1 CD4 CTBP1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A NEUROG3 RCAN1 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGB3 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB5 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 PAK1 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 CDK2 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 GNAI2 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ EPB41L1 STAT5A SFN CREB1 PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ SHC1 PIK3CA CAMK4 NRAS FOXO3 HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 IL18RAP STAT4 STAT3 IL18 CD4 CD86 JUN CD80 PRF1 CD3G IL18R1 CD3D MAPK9 TBX21 FOS IL13 IL2 ETV5 IRF1 CD28 HLA-DRA CD247 PIAS2 HLA-DRB1 IFNG IL2RA CREBBP MAPK8 CD3E TGFB1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 TRIO PAK1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway CDC42 PLCG1 MAPK1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 GNAI2 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA GATA1 PTGS2 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 CLTA GATA3 YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 SND1 HSPA8 CCNA1 MAF CREBBP ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 PPID SKI MAD1L1 BIRC3 COL1A2 CEBPA SP1 CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 CBX4 MPO CDKN2A ATP2B1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 SHC1 EPHB4 PIK3CA PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 PAK1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 RFC1 MAPK8 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 SYK AKT1 CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway PRKRA MADD RB1 CYCS BAX NSMAF BAD NFKB1 PRKCZ PRKCD NFKBIA MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 BIRC3 ASAH1 MYC TRADD MAP3K1 PDGFA SMPD3 AKT1 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 EGF EIF2AK2 TNF PAWR TRAF2 IGF1 RELA TNFRSF1A ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 REL PIK3R1 ARRB2 IKBKB LCK RELA RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C CCN1 ROCK2 SCAI SH3GL2 MAP2K6 MAP2K3 ATF2 CDC42 LIMK2 MAPK8 LIMK1 RDX MSN MRTFA PIP5K1A MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B SOCS3 CSK PTPN1 INSR FER FCGR2A TRPV6 JAK2 LEP STAT5A NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 LEPR PIK3R1 CAPN1 EGF PRLR TXN INS SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events BAX FGFR4 CXCL8 FGFR3 CSF2 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC EPHB2 CAV2 PRKACA TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 RASA1 MAPK8 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 TGFB1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN HES1 POU2F1 HRK ACHE MAPK9 CSRP2 FOS DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 SERPINB5 IFNG CUL3 CCNA2 DDIT3 JDP2 ATF2 MACROH2A1 MAPK8 PPARGC1A PLAU TGFB2 JUND MAPK11 MAPK1 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 MAPK14 ATF3 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 INS EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 CHD3 SAP30 MBD3L2 SMG5 KAT2B PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 SIRT1 NCOR1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC5 HDAC2 HDAC3 HDAC1 HDAC8 GATA2 MAX HDAC9 NR2C1 HDAC6 HDAC7 MTA2 MBD3 RBBP4 SMURF1 MBD2 SAP18 GATAD2B RBBP7 GATAD2A TFCP2 MXD1 CREBBP ZFPM1 SMAD7 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 ITGA3 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 INS FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FBXO32 FASLG G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 CHUK EP300 CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 USP7 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ BCL2L1 FOXO4 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDH1 WASF2 CDC42 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family CDON TGFB2 LRPAP1 STIL DHH HHIP PIK3CA AKT1 PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 HHAT PIK3R1 SHH ARRB2 GRK2 SMO BOC GAS1 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK3 PLK4 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 WASF2 MAP2K6 ATF2 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C ARR3 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 ARHGEF9 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 VEGFA REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 KAT7 MDM2 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 HOXB13 MAPK8 RXRB RXRA SRY RXRG NR3C1 SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 SHC1 SHB PIK3CA JUN SHF ELK1 FOS SRF PIK3R1 PDGFRA SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B AGRP SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E NOS2 CREB1 MEF2A KRT8 PLA2G4A MAPK14 MITF USF1 CEBPB KRT19 PTGS2 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 ATF6 JUN RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network DMP1 MT2A GJA1 NPPA CDKN1B TIMP1 CCL2 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CXCL8 PENK CSF2 BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 MAFG IL6 TRIP6 JUNB FOSB JUN NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 MMP9 IL10 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 ACTA1 IL5 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A CRTC1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events JAK2 STAT5A GRB2 STAT5B SDCBP IL5 LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 PTPN11 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A PXN JUN RUVBL1 NCK2 ILKAP TNS1 PARP1 XPO1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ZEB1 ILK PARVG CDC42 NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 CTNNA1 MAPK8 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 CDH2 PIK3R1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB RXRA VDR RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 MED1 TGFB1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC CHUK EP300 NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG SRA1 CEBPB PHB2 DDX17 PDIA2 HDAC1 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 BRCA1 VTLGL1 SMAD4 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ABCA3 ESR1 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK ELF1 STAT5A NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 ETS1 MAPK1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 ANGPT4 PIK3R1 ANGPT2 NOS3 BMX TNF TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA7 IFNA6 IFNA2 STAT4 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 TNFRSF18 EGR1 FASLG CD8B CD8A PRKCQ IFNA10 IFNAR1 IFNA21 JUNB EGR4 JUN TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS CD3G NFATC3 PTPN7 CD3D NFATC2 MAPK9 NFATC1 FOS PRKCB IL2 PRKCE FOSL1 CD247 KRAS IFNG IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 IFNA4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 ETS1 MAPK1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMA5 LAMC1 LAMA1 LAMA2 LAMA3 LAMB3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 CENPS VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B YAP1 RUNX1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ADA CCNB2 TP63 ITGA3 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 ACTA1 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA CRMA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 TRIO DEF6 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PLD2 TIAM1 PIP5K1A KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT SPHK1 NFKB1 ITK PIK3CA WIPF1 JUN CBLB FCER1A S1PR1 FCER1G LAT2 NFATC2 HCLS1 FOS LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 BTK MAPK1 MAPK3 MAP3K1 SYK AKT1 CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 GNAI2 VEGFA A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK SQSTM1 CDC42 FAIM SHC2 RGS19 SHC3 MAPK1 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L BDNF PIK3R1 NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 ITK PIK3CA FGR HCK NRAS RAP1A FOXO3 HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 BLNK PIK3R1 CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ADAP1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 WWOX JAK2 NRG2 TAB2 STAT5A CBFA2T3 STAT5B GRIN2B EREG NCOR1 BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 SHC1 PIK3CA NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events INPP5D CCL2 JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACG PRKACA YWHAZ SHC1 OSM PIK3CA CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 MAP2K6 CALM3 CDC42 MAPK11 MAPK1 ITGAV MAPK3 SHB AKT1 RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VEGFA VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D ID2 KAT5 FOSL1 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP NBN SMAD3 NME1 EIF4A1 TFRC CDK4 TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A SUPT3H REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 MAP2K6 MAP2K3 MAP3K3 CDC42 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 PAK1 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER EPO JAK2 STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 EPOR AKT1 TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 GRB10 FOXO3 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC VEGFD VEGFA DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 ETS1 MAPK1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 ARF6 PIK3R1 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway WASL PTPN1 PLCG1 STAT1 STAT3 SRC SHC1 PIK3CA PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAK1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP PRKCG ROCK2 TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 GNAI2 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 TP53AIP1 CDK2 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A USP7 SMYD2 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CXCL8 CTLA4 CSF2 GBP3 CREM EGR1 EGR3 FASLG FOXP3 PPARG RNF128 PTGS2 PRKCQ JUNB EGR4 JUN CBLB GATA3 BATF3 POU2F1 NFATC3 NFATC2 ITCH NFATC1 TBX21 E2F1 FOS IL2 FOSL1 IL4 CASP3 IL3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 GNAI2 PAK1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 PLCB3 CDC42 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ GNAI2 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 TXLNG IL6 THBD BGLAP JUNB HMOX1 JUN LIF USF2 NFATC3 DCN NFATC2 MGP NFATC1 IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 MMP1 EP300 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 SMC3 MDM2 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF TRAF2 RELA TNFRSF1A ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A IL12RB2 TNF STAT2 TGFB1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA RTN4R BEX3 MAGEH1 ZNF274 ADAM17 BEX1 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO XIAP MMP7 NTF4 NTF3 NTRK1 TP53 PLG BDNF PIK3R1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 PPP2R5A DVL1 DVL2 AXIN1 CTNNB1 DVL3 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC SHC1 BGLAP PIK3CA JUN KLB FGF1 PAK4 RPS6KA1 NCAM1 FOS GAB1 IL17RD FRS2 SSH1 FGFR2 PTPN11 CTNND1 CDH1 GRB2 PLAU SOS1 SPP1 MAPK1 CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 CDH2 PIK3R1 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 SMAD1 AMHR2 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 PRKDC UBE3A NRIP1 BRCA1 RPS6KA3 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 XRCC6 LATS2 XRCC5 CTDSP1 CTDSP2 MAK ZNF318 SNURF FKBP4 UBA3 KDM3A TMF1 PRDX1 CTNNB1 HNRNPA1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC EGFR PIK3CA AKT1 CTNNB1 RHOA PIK3R1 AKT2 CASR FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP TIMP1 A2M MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 CEBPD AKT1 MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 EPHA5 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 FBXW11 PPP2R2B TIMELESS PLK1 MCM2 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 RFC2 CDK2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 WNT3A CUL1 SKP1 DVL1 DVL2 AXIN1 CTNNB1 DVL3 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 IRS1 YWHAZ PRKD1 SHC1 PIK3CA PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 MAP2K3 CALM3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B MAP2K4 NLRP1 pagA PGR TNF VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods GUCY2F PDE6B RPE65 GNAT1 GRK1 PDE6A CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GUCA1B GNGT1 GUCA1A RHO GUCA1C SAG CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 CCNA2 LAMA4 ONECUT1 TGFA AURKB CREBBP FOXM1 BRCA2 MAP2K1 CENPA CENPB CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A GAS1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 GNAI2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A PLAT FGG ICAM1 JAM3 PLAUR KNG1 VCAM1 ITGAM C3 CD40LG CCN1 ITGB2 ITGAL ITGAX PLAU ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport YWHAE RHOQ GSK3B VAMP2 YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP INS TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS MAPK9 FOS PRKCE KRAS JUND MYC VAV2 WASL CBL USP6NL SLA FYN ACTN4 YES1 SLC9A3R2 SLC9A3R1 RAB4A STAT5B DOCK4 MYOCD ARAP1 PLA2G4A ACTA2 TAGLN SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 LRP1 JAK2 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 NCKAP1 ITGB3 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN RAP1B PTPRM PVR CLDN1 SRC NECTIN3 NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDH1 NECTIN2 CDC42 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB TLN1 F11R IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 ETS1 BTK MAPK1 RAC1 MAP4K1 MAPK3 MAP3K1 SYK AKT1 CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN CSNK2A1 PPP3CB SHC1 PTPN6 PPP3CC CARD11 BCL2A1 POU2F2 BCL10 PPP3CA HRAS MALT1 CD79B CD79A CD19 PTEN SH3BP5 CD72 IBTK PTPRC CD22 MAP3K7 DOK1 NFKBIB RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGAP35 ARHGDIG ARHGEF10L ARHGAP6 ARHGAP4 ARHGDIB OPHN1 ARHGEF1 SRGAP1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 VAV3 MYO9B NET1 OBSCN DLC1 ARHGEF25 ARHGEF15 ARHGEF3 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 TRIO DEF6 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 CCND1 NOTCH2 NOTCH1 KDM1A NOTCH3 MAML2 MYCBP MAML1 NOTCH4 DTX1 DLL1 DLL3 DLL4 RBPJ MARK2 JAG2 JAG1 CUL1 CNTN6 YY1 SKP1 RAB11A DLK1 MIB1 MFAP5 NEURL1 RBBP8 MFAP2 DNM1 CNTN1 SPEN LNX1 NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 SHC1 PIK3CA BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 JAK3 MYC SP1 JAK1 CCND2 LTA PIK3R1 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA SHC1 PPP3CB PIK3CA JUN NRG1 NRAS HRAS DOCK7 MAPK9 ERBB3 FOS PIK3CB CHRNE USP8 NFATC4 RNF41 PTPN11 NF2 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 GNG2 RAC2 VASP PRKCG RAB7A PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA GNAI2 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC1 SDC3 SDC4 SDC2 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions THY1 COL4A3 COL4A6 SDC1 COL4A5 FGG HMGB1 TGFBR2 PLAUR PVR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP PDGFRB EDIL3 PLAU L1CAM SDC4 SPP1 PECAM1 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC COL4A1 TGFBI COL4A4 VEGFA THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA CISH JUN NRAS MAPK9 FOS PRKCB IL2 PRKCE KRAS IFNG IL2RA MAPK8 MAPK11 MAPK1 IKZF3 STAM2 SOCS2 MAPK3 JAK3 STAM MYC JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 ARNTL PER2 DELEC1 PER1 BHLHE40 CRY2 CRY1 WDR5 ATR CLOCK IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B B2M IL12RB1 JAK2 EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG CD8B TYK2 CD8A NFKB1 CD4 IL1B GZMB CD3G IL18R1 CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 HLA-DRB1 IFNG RAB7A IL2RA MAP2K6 ATF2 IL12A SPHK2 CCR5 IL12RB2 IL1R1 RELB CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 TGFBR1 PLAU ITGB8 ITGB5 ITGB7 ITGB6 ITGA4 FBN1 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 PIK3R1 COL4A4 IGF1 COL7A1 VEGFA COL5A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 SIRT2 MYOD1 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB RXRA VDR MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 RARG NCOA2 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network CDKN1B AR COL18A1 APOB CEBPB DSCAM NCOA3 JUN AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD GCG FOXA1 KLK3 NR2F2 NRIP1 PISD FOXA3 BRCA1 NFIA FOXA2 CREBBP NFIB NDUFV3 NFIC NKX3-1 ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH INS NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNA13 PELP1 HBEGF SRC GNA14 GNA15 SHC1 PIK3CA GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 GNAI2 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG BCL9 YWHAH SP5 TCF7L2 NEUROG1 MYF5 CUL1 SKP1 YWHAZ CAMK4 JUN TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF TCF7L1 HDAC2 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TLE5 TCF4 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A MT-CO2 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D EPO JAK2 STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 MAP2K6 MAP2K3 MAP3K3 CALM3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT7L GSK3B PIN1 TAF9 KAT2A PAK2 FBXW7 TAF12 HBP1 MAX PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A SUPT3H S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway KDR PDGFRB PLCG1 MAPK1 RAC1 ABCC1 MAPK3 SPHK1 PTGS2 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ VEGFA GNAI2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR SERPINC1 HCK SLIT2 PRNP PLA2G2A TDGF1 APP LCK SMAD2 GPC1 FGF2 FGFR1 TGFB1 VEGFA ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins ADCY7 EDN1 JAK2 PRKCQ PRKCD GNA14 GNA15 GNA11 JUN GNAQ EDNRA FOS CYSLTR1 PRKCB EDNRB PRKCE CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 CDC42 ADCY6 MAPK8 ADCY5 MAPK1 RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 SLC9A3 COL1A2 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 GNAI2 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR FLT1 NRP1 NRP2 FLT4 VEGFB PGF VEGFC VEGFD VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 NPHS2 AKT1 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GSK3B ADCY7 PLCG1 CXCL8 NFKB1 PRKCD NFKBIA GNA14 PRKD1 GNA15 TRIP6 GNA11 JUN GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 RAC1 ADRA1B AKT1 LPAR1 MMP2 LPAR2 MMP9 LPAR3 RHOA LPAR4 BCAR1 SLC9A3R2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA GNAI2 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions COL6A1 COL4A3 COL4A6 COL6A3 COL4A5 FGG ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 ITGA4 FBN1 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 FGB ITGA9 FGA NPNT NID1 TNC CSPG4 F13A1 TGFBI TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 VEGFA COL5A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling CTSG MMP12 MMP3 MMP13 CTRC GPLD1 LRP1 FGG ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB2 ITGB3 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR HGF ITGA5 FGB MMP9 FGA PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VLDLR PDGFD TGFB1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC ITGA6 EP300 ERBB2 GFI1 CLU RBL1 FTH1 HMGCS2 CREB1 TBP SLC11A1 DNTT DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 TMEM126A HDAC3 S100A7 HDAC1 ALDH9A1 MAX NDRG2 IRF8 NDRG1 ZFP36L1 NFYA FOXO3 NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 BRCA1 SMAD4 PDGFRB CDKN2B SMAD3 CCL5 COL1A2 CEBPA SP1 CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 SRF XPO1 HSP90AA1 UBE2I SUMO1 NCOR2 RFXANK RANGAP1 BCOR ANKRA2 RAN GNG2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 HDAC11 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A ZFYVE9 MAP3K7 PPP2R2A SMAD2 DACT2 RNF111 TGFBR3 SMAD4 ZFYVE16 STRAP GRB2 SOS1 PPP1R15A SMAD3 TGFBRAP1 PPP2CB SPTBN1 SMURF2 SMAD7 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 PRKCQ BAD CABIN1 PRKCD PRKCZ CHP1 PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 MAPK9 NFATC1 XPO1 PRKCB PRKCE FKBP1A CASP3 PRKCH RCAN1 RAN RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 RASGRP1 CD4 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 TRAF6 CDC42 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 RAP1A BCL10 HRAS MALT1 NCK1 PTEN GAB2 PRKCA LCK PTPN11 PTPRC GRB2 SOS1 FLNA DBNL SLA2 RASSF5 PAG1 STIM1 ORAI1 WAS STK39 SH3BP2 CD3E FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 NRP1 NRP2 MAPK1 VEGFB PGF MAPK3 CD2AP AKT1 PIK3R1 NOS3 VEGFA EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins STK36 GSK3B KIF3A CSNK1D SAP30 RAB23 CSNK1E SUFU SPOP MTSS1 BTRC IFT88 CSNK1G2 CSNK1G1 CSNK1A1 FBXW11 HDAC2 PRKCD HDAC1 PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 IFT172 SMO GLI1 CSNK1G3 GLI3 GNAI2 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 SHC1 PIK3CA FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 EXOC1 PIK3R1 INS TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFB PDGFA PDGFRB PDGFC PDGFRA PDGFD EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC SHC1 PIK3CA INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 PAK1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 MAPK9 FOS DUSP1 KRAS RIN1 PEBP1 CALM3 ATF2 AKT1 VAV2 MEF2C ATF1 WASL USP6NL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF ZFP36 STAT1 RALGDS STAT3 MAP2K5 MYLPF PPP5C DIAPH3 ARF4 DUSP6 MAPK7 PIK3CA MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 WASF2 CDC42 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 VLDLR SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB RABGGTA CCNA2 RHOC PTP4A1 PTP4A2 PTP4A3 CDKN1A ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 EPHB4 PIK3CA FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium CREB1 MAPK14 SHC1 FN1 PIK3CA RPS6KA1 ITGB1 GRB2 SOS1 MAPK11 MAPK1 CRK FLT4 ITGA4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC VEGFD ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 LHCGR TSHR USP6 IQSEC1 ARAP2 IPCEF1 ACAP1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 ADAP1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 GATA1 JAG2 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 CHEK1 MAPK11 SERPINE1 FAS NEDD4L ABL1 MYC JAK1 IL1RAP BBC3 IL4R TUBA1A EP300 PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP GRAMD4 CCNB1 PLK3 YAP1 HSF1 CLCA2 BAX BAK1 BUB3 WWOX DEDD GDF15 BUB1 NSG1 TP63 SIRT1 TP53I3 WT1 MAPK14 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 BIN1 SP1 TP53AIP1 CDK2 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAPK14 CXCL13 MTOR CXCR3 PDPK1 CXCL10 CXCL11 SRC PF4 PIK3CA NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK11 MAPK1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 GNAI2 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACG PRKACA YWHAZ SRP9 SHC1 OSM CNKSR1 PIK3CA CISH IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 PTPN11 IL3 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling ROCK1 ICAM1 PRKCQ PRKCD PRKCZ GNA14 RAB11A PRKACA GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE SYK AKT1 RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK SLC9A3R1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR PTGDR HCK PTGIR TBXA2R PLCB2 PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 GNAI2 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ SHC1 PIK3CA IL1A COL17A1 HRAS PMP22 ERBB3 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMA5 LAMC1 RXRG RAC1 EGFR AKT1 ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS CLIP1 MAPKAP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 TSC2 FBXW11 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K HRAS RPS6KA1 PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 RRN3 MAP2K1 POLDIP3 MAP2K2 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10A TNFRSF10D APC TADA2B RGCC JMY MCL1 BCL2L2 TAF9 BTG2 PPP1R13B SFN TRIAP1 CX3CL1 MET AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 PMAIP1 RNF144B RRM2B E2F3 IRF5 TYRP1 JUN HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR ARID3A DUSP5 EDN2 MLH1 CEBPZ DUSP1 SERPINB5 RCHY1 TGFA CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP BDKRB2 TSC2 ATF3 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 CSE1L SP1 EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 AFP CCNB1 PLK3 CAV1 BAX BAK1 GDF15 TP63 TP53I3 COL18A1 TP73 CD82 PTEN PCNA DDIT4 CCNK POU4F1 STEAP3 PRDM1 PYCARD POU4F2 SESN1 TRRAP FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 DDX5 TP53 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A TNFRSF10C TNFRSF10B LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 ADCY1 RPS6KA5 ADCY8 ADCY6 ADCY5 CREB1 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 SLIT1 DSP RAB7A IGF1R IGF2 GDNF CABLES1 CDH1 ZBTB33 CDC42 CTNNA1 CREBBP MEP1B JUP CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 DLGAP5 TACC3 TDRD7 CPEB1 GADD45A AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 PAK1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 TRAF6 MAPK8 MAPK10 MAPK11 CD40 BIRC2 TNFAIP3 C4BPA JAK3 BIRC3 MYC FCAMR MAP3K1 TRAF3 TDP2 AKT1 MAP3K14 MAP2K4 PIK3R1 TRAF2 RELA VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 SMARCB1 NCOA3 ZNF14 UBE2M NCOA1 DDX54 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events YWHAE STRADB GSK3B ETV4 YWHAB STK26 SIK3 SIK1 SIK2 YWHAQ SFN CREB1 YWHAG YWHAH TSC2 MARK2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 TSC1 MLST8 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CRTC2 CTSD BRSK2 SMARCD3 CAB39 TP53 PSEN2 STK11 MAP2 MARK4 STRADA STK11IP EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 EFNB1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 MAP2K5 EGR1 RAP1B PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A HRAS RPS6KA1 FOS SRF CDK5R1 KRAS MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway TNIK CAV1 MADD NSMAF TAB2 NRK TAB1 RFFL MAP4K5 MAP4K3 STAT1 MAP4K2 ADAM17 TNFRSF1B CYLD NFKB1 PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN TRAF2 RELA SMPD2 TNFRSF1A FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks AFP CREB1 G6PC1 CEBPB ACADVL ALAS1 TAT SLC2A2 DLK1 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 APOA1 NF1 HNF1A CPT1C FOXA1 CPT1B GCK FOXA3 BDH1 FOXA2 ALB ALDOB NR3C1 CEBPA SP1 TFRC HNF4A CEBPD AKT1 F2 INS CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 DIAPH3 PRKCZ PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 MAP2K6 ATF2 CDC42 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK PLCB2 FOXO1 ITCH SSH1 LCK ARR3 CFL1 PTPN11 PTPRC PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK RGS1 CXCL12 VPS4B VPS4A GRK6 GNAI3 UBQLN1 GNAI1 PAG1 PIK3R1 GNAO1 CD3E GNAZ VAV1 GNAI2 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 ETV1 YWHAZ LSP1 CDC25B TCF3 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 PPARD DTX1 DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 CSNK2A1 DVL1 JUN TLE1 FOS MAP3K7 HNF1A LRP6 CREBBP WIF1 MAPK1 FZD1 MAPK3 MYC NKD1 PPP2R5D FRAT1 PSENEN AXIN1 CTNNB1 NLK DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms SSRP1 DHRS3 YWHAQ ADA ITGA3 JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 BBC3 CHUK EP300 FLOT2 S100A2 SMARCD3 AEN SHH CLCA2 BAX BTRC GDF15 MFGE8 TP63 EGR2 TP53I3 PERP GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL NQO1 CDKN2A TFAP2C IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL PTGES2 CAMK2D CAMK2A SOCS1 IRF9 JAK2 DAPK1 STAT1 CAMK2B STAT3 RAP1B MTOR CEBPB PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 ARFGAP1 PLD2 GGA3 PIP5K1A ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 IL1RN ERC1 NFKB1 PRKCZ TICAM2 IL1R2 IRAK3 PIK3CA TOLLIP JUN UBE2V1 IL1B IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 TRAF6 SQSTM1 MAPK8 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B SGK1 FGG STAT5A SFN CXCL8 ICAM1 STAT1 CSF2 YWHAH EGR1 PPP5C NFKB1 PRKACA IL6 BGLAP JUN VIPR1 SUMO2 POU2F1 KMT5B POU1F1 SMARCC2 MAPK9 NFATC1 FOS FKBP5 TBX21 IL13 SMARCD1 IL2 TSG101 IRF1 NR1I3 CGA IL4 MDM2 SMARCC1 PCK2 PBX1 CDK5R1 KRT17 IFNG CDKN1A MAPK8 MAPK10 SPI1 MAPK11 MAPK1 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 CDK5 NCOA2 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG KRT5 GATA3 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC SHC1 PIK3CA RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB TSG101 USP8 PTK2 KRAS UBE2D2 ZFYVE28 UBE2D3 SH3GL2 EPN1 CHMP3 CDC42 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A UXT PLAU MYBL2 SERPINE1 SULT2A1 CES4A TFDP2 XRCC1 MCM3 CES3 CES2 MYC CES1 CES1P1 CBX5 TYMS CES5A EP300 ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C CCNE2 DHFR POLA1 TFE3 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 CDK1 E2F4 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 CEBPA SP1 TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway RIPK2 RAN IKBKG UBE2D3 TRAF6 BTRC CYLD BIRC2 TNFAIP3 NFKB1 ERC1 NFKBIA CHUK BCL10 MALT1 ATM XPO1 IKBKB TNF PRKCA NOD2 RELA TNFRSF1A EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling FYN EFNA5 EPHA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 RAP1A BCL10 HRAS MALT1 PRKCA LCK PTPRC GRB2 SOS1 RASSF5 PAG1 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 TERF2 IFNG BLM MAPK1 ABL1 SIN3B MAPK3 SIN3A MYC AKT1 HUS1 NCL RAD1 PINX1 TGFB1 SMG6 RAD9A E6 SAP30 PARP2 SMG5 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR ZNFX1 HNRNPC HDAC2 HDAC1 RPS6KB1 MAX TERT RBBP4 E2F1 HSP90AA1 SAP18 RBBP7 MXD1 MRE11 NR2F2 UBE3A NBN SMAD3 XRCC6 ESR1 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 SMARCB1 EP300 MEF2C PPP2CA RUNX2 TFDP1 TBP SIRT1 MYOD1 MAPK14 MITF PPARG CEBPB SUV39H1 AATF HDAC3 BRD2 HDAC1 PAX3 CTBP1 RBP2 ATF7 DNMT1 CKM PPP2R3B TAF1 RBBP4 GSC E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CEBPD CDK2 CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 TGFBRAP1 MAPK1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL NUP153 PPM1A UBE2I HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 MCL1 EPO LEP CITED2 NOS2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 HMOX1 JUN TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 NPM1 HNF4A AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 IGFBP1 TERT BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM PLIN2 GCK ALDOA SMAD4 ABCB1 CREBBP PFKFB3 FECH SMAD3 NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 VEGFA REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway GSK3B CBL ARHGEF2 FYN GRIN2B ITGA3 MAP1B PIK3CA LRP8 RELN RAP1A MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A MAPK8IP1 CRKL RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 VLDLR TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 TNFSF10 MAPK3 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TNFRSF10C TRAF2 TNFRSF10B RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling CRH GNG2 GNB1 MAPK8 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP PTPN1 INSR STAT6 STAT5A RAB4A STAT5B MET STAT1 STAT3 SRC SHC1 PIK3CA KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR PDGFRB CREBBP GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R LMAN1 JAK1 KPNA2 EGFR HGF CSF1 EIF2A ATR PIK3R1 EGF EIF2AK2 INS VEGFA BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling BMPR1A GSK3B SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMURF2 SMAD7 SKI CTDSP1 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV SOSTDC1 BMP4 CER1 AHSG FST NOG SMAD6 BMPR2 RGMB BMP6 RGMA SMAD1 GREM1 BMP2 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 F2RL3 ROCK2 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CLOCK ARNTL PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2A ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNA15 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNA15 GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG CX3CL1 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGAX ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A1 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL4 IL6 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA FOS IL1A PIK3CA IL23A IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRM1 GRIN2D GRIN1 GNA15 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway MYO1E MYO1B MYO1C SLC6A8 ACTC1 MYO1A MYO15A MYO5B MYO5C CHRFAM7A MYO1F MYO1G SLC44A3 ACTB ACTG2 ACTG1 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB2 CHRNB1 CHRNB4 CHRNB3 MYH15 MYO7B MYO7A ACTA2 MYH1 ACTA1 SLC5A7 MYH2 MYH3 ACTBL2 MYO3B CTAGE4 MYO3A CTAGE9 MYH8 MYH9 MYH4 MYH6 CTAGE15 MYH7 CHRNA1 CHRNA3 CHRNA2 PLEKHH3 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 MYH11 MYH10 MYH7B MYO10 MYO5A MYO9A MYO19 MYO16 MYO1D NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIR1 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNA15 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 YLR446W PGI1 SPR1 GSC2 TPS3 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 TSTA3 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-t2 Galk sgl Pgm1 UGP GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Dmel\CG10467 PyK Gapdh1 Ald1 Eno Pglym87 Pglym78 Tpi Hex-t2 Pgi Pfk Glut1 CG15400 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Tor INPP5E CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Dmel\CG6910 fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Prps Rpe Ald1 Taldo Rpi Dmel\CG13369 Dera anon-WO0118547.344 Pgi Pfk fbp CG17333 Zw Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Ipp CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ipk1 anon-WO0172774.149 Aps l(1)G0196 INPP5E WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect ScsbetaG Pglym87 Pdha SdhD Pdhb SdhC SdhB Pgd SdhA PCB Fum1 Hex-t2 Pgi kdn Pgk muc CG17333 Irp-1A PyK Gapdh1 Ald1 Eno Taldo Rpi Gdh Scsalpha1 Idh E3 GLS anon-WO0118547.344 Pfk Mpc1 Glut1 Mct1 Eaat1 CG1544 Zw alpha-KGDHC Mdh1 mAcon2 Idh3a GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis aldo-1 pfk-1.1 gpd-3 hxk-1 enol-1 pyk-1 C01B4.6 tpi-1 fgt-1 gpi-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 CELE_R01H10.7 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 gba-3 cgt-3 C27A7.1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway CELE_F08F8.7 F09E5.3 gspd-1 CELE_R05F9.6 Y57G11C.3 tald-1 CELE_R151.2 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 CELE_R01H10.7 ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 fgt-1 T05H10.6 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 mev-1 Y57G11C.3 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.2 Long-term potentiation CAMK2B GRIA1 GRIA2 CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2C GRIN2B GRIN1 NRGN GRIN2D GRIN2A DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 80%114294 Activation, translocation and oligomerization of BAX BID BAX GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.4 Glycerophospholipid biosynthesis LPGAT1 CPNE7 PITPNB CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A PCYT2 DGAT2 MIGA2 MIGA1 DGAT1 CSNK2A1 STARD7 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 PLA2G10 GPD1 CSNK2B PLBD1 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLA2G6 PLD1 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 CHKB TMEM86B OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP OSBPL10 ACP6 PCYT1B PLA2G4F PLA2G12A PCYT1A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PLA2G1B AGPAT1 AGPAT2 SELENOI AGPAT3 AGPAT4 AWAT2 GPAT4 GPAT3 CEPT1 GPAT2 CDIPT PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A MBOAT1 DDHD2 MBOAT2 DDHD1 ETNPPL GPAM ETNK2 LPCAT4 ETNK1 LPCAT3 LPCAT2 PNPLA3 CHPT1 GPD1L LPIN1 LPIN2 LPIN3 PNPLA2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.1 Regulation of PLK1 Activity at G2 M Transition CEP57 YWHAE CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 OFD1 HSP90AA1 CEP135 PPP1R12A BORA FBXW11 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 UBA52 SFI1 AJUBA OPTN SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 80%1170546 Prolactin receptor signaling BTRC SKP1 STAT5A STAT5B CUL1 CSH1 PTPN11 PRL PRLR RBX1 GH2 GHR GH1 JAK2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.1 Activation of NF-kappaB in B cells IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 IKBKG MAP3K7 CHUK PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CARD11 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BCL10 PSMA7 RELA MALT1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC NFKB1 PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE FBXW11 NFKBIB UBA52 CUL1 UBB UBC RPS27A STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 80%3249367 STAT6-mediated induction of chemokines TBK1 STING1 STAT6 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 80%9697154 Disorders of Nervous System Development NCOR1 TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X CALM1 NCOR2 PRKACA HDAC3 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 80%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer RPS27A SHC1 EGF GAB1 PIK3R1 UBA52 CBL EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 UBB UBC DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.4 Degradation of the extracellular matrix PRSS1 COL16A1 COL12A1 CAPN15 CAPN8 CAPN9 CAPN6 CAPNS1 CAPN7 CDH1 CAPNS2 CAPN5 BSG CAPN2 CAPN3 CAPN1 PRSS2 CAST PHYKPL CTRB2 COL23A1 CTRB1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 PSEN1 KLK2 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LAMC1 CTSV CTSS MMP20 ADAMTS4 ADAMTS5 MMP25 MMP24 CTSL ADAMTS1 CASP3 CTSK TIMP2 CTSG TIMP1 TPSAB1 ADAMTS8 CTSD ADAMTS9 CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 CD44 LAMA5 COL15A1 TMPRSS6 LAMA3 PLG FURIN COL19A1 ACAN SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 TLL1 KLKB1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 80%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2AX H2AB1 H2AC19 HJURP RSF1 H2AC14 H2BC12L MIS18BP1 H2BC21 RUVBL1 OIP5 H2BU1 H2AC8 H2AC6 H2AC7 KNL1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ITGB3BP CENPA CENPC RBBP4 RBBP7 H2AZ1 H2BC9 CENPT H2AZ2 CENPU NPM1 H4C9 H2BC8 CENPW CENPX H2BC5 H2BC3 SMARCA5 H2BC1 MIS18A CENPH CENPI H2AC20 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 80%2871837 FCERI mediated NF-kB activation IGKV1-17 IKBKB PSMD8 IGKV1-12 PSMD9 IGHV3-7 PSMD6 IGHV3-9 PSMD7 V2-11 PSMD4 IGHV3-30 PSMD5 V3-4 PSMD2 V3-3 PSMD3 V2-17 PSMD1 V3-2 IGHV3-33 IKBKG MAP3K7 V2-15 IGKV1D-39 CHUK V2-19 IGKV1D-33 PSMA5 CDC34 PSMA6 IGKV2D-28 PSMA3 IGKV4-1 PSMA4 IGHV7-81 PSMA1 PRKCQ PSMA2 PSME3 UBE2V1 PSME4 V1-11 PSME1 IGKV2D-30 PSME2 V1-16 CARD11 V1-13 PSMD10 IGHV4-59 IGHV1-69 PSMB11 PSMD12 RASGRP2 PSMD11 RASGRP1 PSMD14 RASGRP4 PSMD13 IGLV2-11 BCL10 IGLV1-40 IGLV1-47 PSMA7 IGLV6-57 RELA IGLV2-14 MALT1 IGLV1-44 PSMB10 IGKV3-15 PSMA8 IGKV3-11 PSMB6 LYN PSMB7 V2-8 PSMB4 V1-20 PSMB5 IGKV2D-40 PSMB2 IGHV3-11 PSMB3 IGHV3-13 PSMB1 PSMF1 IGKV1D-16 IGLV7-43 NFKB1 IGKV1D-12 PSMB8 IGLV1-51 PSMB9 NFKBIA IGLV2-23 SEM1 UBE2N TAB3 PSMC5 TAB2 PSMC6 TAB1 PSMC3 IGKV3-20 PSMC4 IGHV4-34 PSMC1 IGHV1-2 PSMC2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 PDPK1 V1-3 IGKV3D-20 V5-6 TRAF6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 BTRC SKP1 FBXW11 UBA52 CUL1 UBB UBC RPS27A UBE2D2 IGHV3-23 UBE2D1 IGLV IGLV2-8 IGKV1-16 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.1 Hedgehog 'off' state PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 IFT172 PRKACG PRKACB DYNC2H1 RPGRIP1L IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 INTU KIF3A TTC21B PRKAR2A PTCH1 IFT122 FUZ ADCY10 MKS1 GNAS GSK3B GLI1 GLI3 GLI2 IFT52 SUFU IFT57 IFT140 KIF7 WDR35 NUMB ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 WDR19 ITCH BTRC PRKACA SKP1 OFD1 UBA52 CUL1 UBB PRKAR2B UBC RPS27A RBX1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 80%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP NOTCH1 MAML2 ONECUT3 MAML1 ONECUT1 HNF1B RBPJ KAT2B KAT2A SNW1 EP300 HES1 MAML3 MAMLD1 NEUROG3 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.2 Interleukin-33 signaling IL33 IL1RL1 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 80%9723907 Loss of Function of TP53 in Cancer TP53 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.1 Regulation of RAS by GAPs PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 SPRED3 PSMD13 SPRED2 SPRED1 PSMA7 SYNGAP1 RASA3 RASA4 PSMB10 RASA1 PSMA8 RASA2 PSMB6 CUL3 PSMB7 RASAL1 PSMB4 RASAL2 PSMB5 RASAL3 PSMB2 PSMB3 DAB2IP PSMB1 NF1 PSMF1 KBTBD7 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 NRAS HRAS UBB UBC RPS27A RBX1 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.2 Alternative complement activation CFB C3 CFD GZMM NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.2 Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 80%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta IKBKB IKBKG ITCH CREBBP CHUK EP300 RELA NFKB1 NFKBIA HSP90AA1 NFKBIB IFNA5 TBK1 IFNA4 OTUD5 APP IFNA7 IFNA6 HSP90AB1 UBE2D3 IFNA2 TNFAIP3 UBE2L6 HMGB1 IFNA8 HERC5 IFIH1 TRAF6 CASP8 TRIM4 CASP10 UBA52 NKIRAS1 NKIRAS2 DHX58 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 TRAF2 ATG12 SIKE1 RNF125 UBB IRF3 TRAF3 IRF7 TAX1BP1 UBC IFNA10 NLRX1 UBA7 RPS27A NLRC5 AGER TANK RNF135 TKFC RNF216 PCBP2 S100A12 RIPK1 FADD ATG5 IFNA21 MAP3K1 IFNB1 ISG15 S100B NFKB2 CYLD MAVS SAA1 PIN1 UBE2K UBE2D2 UBE2D1 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.2 Diseases of mitotic cell cycle ANAPC11 FZR1 CCND3 CDC23 CCND2 CCND1 CDC26 CDC27 E2F1 E2F2 E2F3 SKP2 DAXX ANAPC7 UBE2C ATRX UBE2E1 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RB1 CDKN1C CDKN1A ANAPC15 UBE2D1 CDKN1B ANAPC16 ANAPC10 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 80%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 SPRY REGULATION OF FGF SIGNALING%REACTOME%R-HSA-1295596.1 Spry regulation of FGF signaling PPP2CA PPP2CB MKNK1 RPS27A MAPK1 SPRY2 MAPK3 PPP2R1A UBA52 CBL PTPN11 UBB BRAF UBC SERINE BIOSYNTHESIS%REACTOME%R-HSA-977347.4 Serine biosynthesis SRR PSAT1 PHGDH SERINC1 SERINC3 SERINC2 SERINC5 PSPH SERINC4 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 80%1299503 TWIK related potassium channel (TREK) KCNK2 KCNK4 KCNK10 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 80%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 80%71336 Pentose phosphate pathway TKT RBKS PRPS2 PRPS1 G6PD RPEL1 RPE TALDO1 PGD DERA RPIA SHPK PGM2 PGLS PRPS1L1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 80%389359 CD28 dependent Vav1 pathway CD86 CDC42 PAK1 LCK CD80 CD28 FYN RAC1 PAK3 PAK2 VAV1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 80%5689877 Josephin domain DUBs VCP RAD23A JOSD2 RPS27A JOSD1 RAD23B UBB UBA52 PRKN ATXN3 ATXN3L UBC DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 80%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 GPC2 GPC5 CSPG4 DCN GPC4 AGRN GPC6 HSPG2 BCAN SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-HSA-8851680.3 Butyrophilin (BTN) family interactions XDH PPL BTNL9 BTNL8 BTN2A2 BTN3A1 CD209 BTN2A1 BTN1A1 BTN3A3 BTNL2 BTN3A2 PLASMA LIPOPROTEIN REMODELING%REACTOME DATABASE ID RELEASE 80%8963899 Plasma lipoprotein remodeling GPIHBP1 FGF21 MBTPS1 APOA2 APOC3 APOA1 APOA4 APOA5 APOC2 ALB ANGPTL8 ANGPTL3 P4HB ANGPTL4 LPA MBTPS2 ABCG1 CETP MTTP FURIN LCAT LPL PCSK6 PCSK5 LMF2 LMF1 LIPC CREB3L3 LIPG APOF APOE APOB PROTEIN FOLDING%REACTOME%R-HSA-391251.1 Protein folding CCNE2 CCNE1 CSNK2A1 CSNK2A2 CSNK2B HDAC3 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 TP53 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 XRN2 GAPDHS FKBP9 ARL2 GNG10 TUBA1A TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNAQ GNB2 TBCE GNB1 GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 KIF13A CCT3 CCT2 VBP1 SPHK1 TUBA4A TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 GBA TUBA3E GNA14 AP3M1 TUBA3D GNA15 GNG3 TUBA3C GNG2 GNG5 GNG4 GNA11 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 STAT3 RGS11 TUBB4B TUBB4A DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.1 Drug resistance in ERBB2 TMD JMD mutants CDC37 HSP90AA1 ERBB2 ERBIN DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.3 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 80%182218 Nef Mediated CD8 Down-regulation AP2M1 CD8B AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.1 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 80%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 80%3108214 SUMOylation of DNA damage response and repair proteins BMI1 HERC2 SUMO3 SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 NUP210 RING1 NUP133 PARP1 NSMCE3 NSMCE2 NSMCE1 SMC1A PIAS1 NUP93 RNF168 EID3 NSMCE4A NUP50 NUP54 SP100 NUP205 POM121 BLM XPC AAAS NUP160 RNF2 HDAC7 WRN CETN2 POM121C NUP42 NUP85 RAD21 TDG TPR NUP88 NUP43 RAE1 RANBP2 CBX8 PHC2 PHC1 XRCC4 NUP155 CBX4 CDKN2A CBX2 PCGF2 UBE2I RPA1 NUP153 SUMO1 PHC3 PML RAD52 STAG1 STAG2 NUP35 NUP37 MDC1 NUP107 NUP188 SMC5 SMC6 BRCA1 SMC3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.1 Cytosolic tRNA aminoacylation RARS1 KARS1 MARS1 YARS1 DARS1 WARS1 AIMP1 GARS1 AIMP2 SARS1 EPRS1 NARS1 QARS1 PPA1 LARS1 IARS1 FARSA EEF1E1 CARS1 TARS1 FARSB VARS1 HARS1 AARS1 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.2 Alternative Lengthening of Telomeres (ALT) DAXX ATRX PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 80%1250342 PI3K events in ERBB4 signaling PIK3CA NRG1 BTC NRG3 NRG4 NRG2 HBEGF EREG PIK3R1 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 80%9759218 Cobalamin (Cbl) metabolism MMUT MMACHC MMADHC MTRR MMAA MMAB MTR SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.2 SUMO is conjugated to E1 (UBA2:SAE1) SUMO3 SUMO2 UBA2 SAE1 SUMO1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.3 Transport of Mature mRNA derived from an Intron-Containing Transcript FYTTD1 LUZP4 RBM8A POLDIP3 NUP62 SRSF1 NUP214 U2AF1 NDC1 U2AF1L4 NXF1 SEC13 U2AF2 NUP210 DHX38 SRSF11 NUP133 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP37 NXT1 EIF4A3 CASC3 GLE1 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 NUP107 SRSF4 NUP188 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 80%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER UBA52 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 UBB LIG1 RFC1 RFC2 RPA2 UBC XRCC1 LIG3 POLE4 RPS27A RPA3 POLE2 POLE3 RPA1 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.4 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 AGO1 AGO2 DICER1 TSN TARBP2 TRP CHANNELS%REACTOME%R-HSA-3295583.2 TRP channels TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.2 Vitamin B5 (pantothenate) metabolism PANK4 PANK2 PANK3 PANK1 COASY PPCDC SLC5A6 SLC25A16 VNN1 VNN2 PPCS PDZD11 FASN ENPP2 ENPP1 ENPP3 AASDHPPT SHC-MEDIATED CASCADE:FGFR1%REACTOME%R-HSA-5654688.1 SHC-mediated cascade:FGFR1 FGF22 FGF10 NRAS SOS1 HRAS FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 80%2206305 MPS IIID - Sanfilippo syndrome D GNS DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 80%5696400 Dual Incision in GG-NER PARP1 UBA52 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC POLE4 RPS27A RPA3 XPA POLE2 PARP2 POLE3 GTF2H1 CHD1L GTF2H2 GTF2H3 GTF2H4 GTF2H5 DDB2 CUL4A DDB1 ERCC3 ERCC4 ERCC1 ERCC2 ERCC5 CUL4B RPA1 RBX1 UNWINDING OF DNA%REACTOME%R-HSA-176974.2 Unwinding of DNA GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 80%416993 Trafficking of GluR2-containing AMPA receptors NSF PRKCG PRKCA GRIP2 GRIP1 TSPAN7 PICK1 GRIA3 GRIA4 GRIA1 GRIA2 PRKCB AP2A1 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 80%399710 Activation of AMPA receptors GRIA3 GRIA4 GRIA1 GRIA2 MTOR SIGNALLING%REACTOME%R-HSA-165159.6 MTOR signalling PRKAA1 PRKAA2 CAB39 CAB39L YWHAB PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 EEF2K AKT2 MLST8 EIF4EBP1 AKT1 SLC38A9 EIF4E EIF4B PRKAB2 STRADA STRADB RPS6 TSC2 TSC1 PRKAB1 MTOR FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB AKT1S1 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 EIF4G1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.1 Loss of Function of TGFBR2 in Cancer TGFB1 TGFBR1 TGFBR2 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.1 RAC3 GTPase cycle BAIAP2 MPP7 VANGL1 ARHGAP32 DIAPH3 TAOK3 ABI2 ABI1 NOXA1 NOX3 ESYT1 NOX1 FERMT2 LAMTOR1 ITGB1 NCKAP1 CYFIP1 TRIO NCF1 TFRC NCF2 SNAP23 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 CDC42 DOCK10 PAK1 SYDE1 PREX1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB PAK2 RAC3 PIK3R1 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 VAV2 BCR TIAM1 DEPDC1B RAPGEF1 CDC42EP1 DSG2 RAB7A EPHA2 VAMP3 GARRE1 AMIGO2 NOXO1 PIK3R2 ARHGAP17 SLC1A5 ERBIN ARHGAP15 LMAN1 ABR ARHGAP21 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SLITRK5 NCKAP1L WASF1 SRGAP2 WASF2 YKT6 PAK4 IL32 GIT2 JAG1 CAV1 MCAM MCF2 ARHGAP26 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 RB1 CDK2 CDKN1C CDKN1A CDKN1B METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 80%6799990 Metal sequestration by antimicrobial proteins S100A8 LTF S100A7 S100A7A LCN2 S100A9 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.1 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 80%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBA52 UBE2C CDC34 UBE2E1 UBE2S UBA6 UBE2Z UBE2L3 UBE2Q2 USP7 UBB UBE2H USP5 UBE2B USP9X UBC UBE2E3 UBE2G1 UBE2A RPS27A UBE2G2 UCHL3 UBE2W UBE2R2 UBE2T OTULIN UBA1 UBE2K UBE2D2 UBE2D1 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 80%5654699 SHC-mediated cascade:FGFR2 FGF22 FGF10 FGF16 FGF7 FGF18 NRAS SOS1 HRAS FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.2 ERKs are inactivated PPP2CA PPP2CB MAPK1 MAPK3 PPP2R1A DUSP4 DUSP3 PPP2R5D VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.1 APC truncation mutants are not K63 polyubiquitinated APC FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-140877.2 Formation of Fibrin Clot (Clotting Cascade) CD177 FGB FGA VWF KLKB1 F10 SERPIND1 GP1BB F12 F2R F11 FGG GP1BA F2 F3 GP5 F5 GP9 F7 PROCR F8 PROC F9 SERPING1 PRTN3 F13B PF4 SERPINE2 SERPINC1 PROS1 F13A1 PRCP TFPI KNG1 SERPINA5 THBD C1QBP A2M PF4V1 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.1 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC11 FZR1 CDC23 CDC26 CDC27 SKP2 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 RB1 ANAPC4 ANAPC5 ANAPC15 UBE2D1 ANAPC1 ANAPC2 ANAPC16 ANAPC10 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 80%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ECHS1 ACADM HADH RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.2 Recognition of DNA damage by PCNA-containing replication complex UBA52 PCNA POLD3 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 UBB RFC1 WDR48 UBE2B RFC2 USP1 RPA2 UBC DTL RAD18 POLE4 RPS27A RPA3 POLE2 POLE3 CUL4A DDB1 CUL4B RPA1 RBX1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.2 SUMO is transferred from E1 to E2 (UBE2I, UBC9) RWDD3 SUMO3 SUMO2 UBA2 SAE1 UBE2I SUMO1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.2 Eukaryotic Translation Elongation RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 EEF1G EEF1A1 EEF1D EEF1A2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 EEF1A1P5 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A EEF2 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 EEF1B2 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 80%157579 Telomere Maintenance DAXX ATRX PCNA POLD3 POLD4 POLD1 POLD2 RFC5 RFC3 CDK2 RFC4 LIG1 BLM RFC1 RFC2 RPA2 WRN RPA3 RPA1 WRAP53 FEN1 DSCC1 CHTF18 PPP6C RUVBL2 PPP6R3 H2AX H3-3B H2AB1 TINF2 H2AC19 TERF1 TERF2 CCNA2 H2AC14 CCNA1 H2BC12L SHQ1 DKC1 H2BC21 NHP2 RUVBL1 POT1 TERF2IP H2BU1 DNA2 H2AC8 PIF1 H2AC6 PRIM2 H2AC7 RTEL1 PRIM1 H2BC17 CHTF8 H2BC12 TERT H2BC13 POLR2A H2BC14 POLR2B H2AJ POLR2C H2BC15 POLR2D H2BC11 GAR1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J H2AZ1 POLR2K H2BC9 POLR2L CTC1 H2AZ2 ANKRD28 STN1 ACD H4C9 H2BC8 POLA1 POLA2 TEN1 H2BC5 H3-4 H2BC3 NOP10 H2BC1 H2AC20 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.2 Platelet homeostasis PECAM1 ORAI2 ORAI1 PDE5A PDE9A PDE1B PDE1A ITPR1 ITPR2 ITPR3 SRI LRP8 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 NOS2 NOS3 PDE2A ATP2B4 ATP2B3 ATP2B2 ATP2B1 MAPK14 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 CALM1 PDE10A P2RX4 PPP2CA P2RX3 PPP2CB P2RX2 P2RX1 PTPN6 GNG10 PPP2R1A GNG12 PPP2R5D GNG11 GNG13 GNB2 PPP2R1B GNB1 GNB4 TRPC7 GNB3 TRPC6 GNB5 TRPC3 GNGT1 GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GUCY1B2 PLA2G4A GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PPP2R5E GNAS PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR PTPN11 IRAG1 PPP2R5B PPP2R5A PPP2R5C FGR STIM1 KCNMA1 APOB IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 80%937039 IRAK1 recruits IKK complex IKBKB UBE2N IRAK1 UBE2V1 PELI3 PELI2 PELI1 TRAF6 IKBKG CHUK NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 80%180746 Nuclear import of Rev protein NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 NPM1 TPR RCC1 NUP88 NUP43 RAN RAE1 KPNB1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.1 Signaling by NOTCH1 HD Domain Mutants in Cancer RPS27A JAG2 ADAM10 NOTCH1 MIB2 UBA52 DLL1 MIB1 ADAM17 DLL4 NEURL1B NEURL1 JAG1 UBB UBC SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%R-HSA-3304356.2 SMAD2 3 Phosphorylation Motif Mutants in Cancer SMAD2 TGFB1 SMAD3 TGFBR1 TGFBR2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.2 Factors involved in megakaryocyte development and platelet production KIF6 RBSN KIF27 RAD51B KIF9 RAD51C KIFC2 KIF2A KIFC1 IRF1 IRF2 KIF2C KIF2B DOCK2 DOCK1 HDAC2 AKAP1 H3C15 MFN1 MFN2 SH2B3 SH2B2 SH2B1 CABLES1 CABLES2 CDK2 CENPE WEE1 KIF26A CAPZA1 KIF26B CAPZA2 VPS45 HDAC1 SIN3A CDC42 DOCK10 H3-3B RAC1 PRKACG PRKACB PRKAR1B PRKAR1A KIF3A PRKAR2A RACGAP1 TP53 PRKACA KIF28P KDM1A JMJD1C DOCK11 KIF5C KIF5B KIF5A MYB IFNA5 KIF21A IFNA4 KIF21B KIFAP3 HBE1 IFNA7 KIF16B IFNA6 KIF20A KIF20B ZFPM2 IFNA2 ZFPM1 GATA6 GATA5 AK3 IFNA8 GATA4 GATA3 KLC1 GATA2 GATA1 PHF21A KLC4 KLC3 KLC2 KIF3B MICAL1 IFNA13 ABL1 IFNA14 KIF3C IFNA16 NFE2 CARMIL1 IFNA17 CBX5 HBG2 HBG1 EHD1 EHD2 KIF18A PRKAR2B EHD3 KIF18B CDK5 IFNA10 KIF4B KIF4A MAFG MAFF MAFK RAB5A RCOR1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 DOCK7 IFNA21 HBB KIF12 KIF11 IFNB1 HBD KIF15 AKAP10 KIF19 CAPZB KIF13B KIF1C HMG20B KIF1B KIF1A H3C8 ITPK1 KIF25 KIF23 JAK2 KIF22 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 80%8951430 RUNX3 regulates WNT signaling TCF7L2 TCF7L1 MYC TCF7 LEF1 CCND1 CTNNB1 RUNX3 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.2 ATP sensitive Potassium channels KCNJ8 KCNJ11 ABCC8 ABCC9 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.1 Suppression of phagosomal maturation RAB7A RPS27A RAB5A KPNB1 VPS33B CORO1A ATP6V1H UBA52 HGS KPNA1 NOS2 UBB UBC P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.3 p53-Dependent G1 S DNA damage checkpoint PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME4 PSME1 CCNE1 PSME2 PSMD10 CDK2 PSMB11 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PHF20 PSMB9 CHEK2 ZNF385A SEM1 COP1 CDKN2A PSMC5 PCBP4 PSMC6 PSMC3 MDM2 PSMC4 MDM4 PSMC1 ATM PSMC2 CCNA2 CCNA1 UBA52 UBB UBC RPS27A CDKN1A CDKN1B DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 80%9669914 Dasatinib-resistant KIT mutants KIT PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 80%622323 Presynaptic nicotinic acetylcholine receptors CHRNG CHRNA4 CHRNE CHRNA6 CHRNB2 CHRNA1 CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.4 Lipoprotein metabolism GPIHBP1 FGF21 MBTPS1 APOA2 APOC3 APOA1 APOA4 APOA5 APOC2 ALB ANGPTL8 ANGPTL3 P4HB ANGPTL4 LPA MBTPS2 ABCG1 PRKACA FURIN CLTC HDLBP PCSK9 CLTA VLDLR ZDHHC8 LIPA LDLRAP1 MYLIP UBA52 CUBN AMN LSR NPC1 SOAT1 SOAT2 NPC2 CES3 SAR1B LDLR ABCA1 NR1H2 APOC4 NR1H3 UBB APOBR NCEH1 APOC1 UBC PRKACG PRKACB RPS27A AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 CETP MTTP LCAT LPL PCSK6 PCSK5 LMF2 LMF1 LIPC CREB3L3 LIPG APOF APOE A2M APOB FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 80%217271 FMO oxidises nucleophiles FMO3 FMO1 FMO2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-HSA-937042.2 IRAK2 mediated activation of TAK1 complex IRAK2 TAB3 RPS27A TAB2 TAB1 TRAF6 UBB MAP3K7 UBA52 UBC AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 80%209563 Axonal growth stimulation NGFR ARHGDIA NGF RHOA INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.2 Inactivation of APC C via direct inhibition of the APC C complex ANAPC11 CDC23 BUB1B CDC26 CDC20 CDC27 BUB3 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC15 UBE2D1 ANAPC1 ANAPC2 ANAPC16 ANAPC10 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.1 CD163 mediating an anti-inflammatory response FURIN MAPK14 IL10 IL6 CD163 PLK2 ADAM17 RHBDF2 MYH9 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 80%428157 Sphingolipid metabolism ENPP7 CERS3 CERS4 ARSA CERS5 CERS6 SPHK2 SPNS2 SUMF2 SUMF1 PRKD3 ESYT1 CPTP PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 CERS1 CSNK1G2 CERS2 ASAH1 SAMD8 ASAH2 PPM1L SGMS1 SGMS2 NEU2 UGCG UGT8 NEU3 ALDH3B2 SGPL1 ARSL ALDH3B1 ARSJ ORMDL2 NEU1 ARSK ORMDL3 PSAP ARSH ARSI ARSF B4GALNT1 SPTSSB ARSG KDSR SPTSSA ARSD ARSB CTSA B3GALNT1 ORMDL1 SGPP2 SGPP1 GALC ACER2 FA2H ACER1 GLB1L VAPA GLB1 VAPB ACER3 ESYT3 ESYT2 DEGS1 DEGS2 SPHK1 GBA GLTP CERK HEXB HEXA GBA3 GBA2 SMPD3 SMPD2 STS SPTLC1 SMPD4 GM2A SPTLC2 SPTLC3 SMPD1 OSBP MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.2 Maturation of spike protein ST6GALNAC2 RPN2 TUSC3 ZDHHC20 PRKCSH RPN1 ZDHHC8 ZDHHC5 MAGT1 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 GOLGA7 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 DAD1 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 80%193692 Regulated proteolysis of p75NTR RELA NGFR PSEN1 APH1A PSENEN TRAF6 APH1B PSEN2 NCSTN NFKB1 ADAM17 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 80%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 80%77387 Insulin receptor recycling INSR ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1H ATP6V1A TCIRG1 INS ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 ATP6V1F ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.3 Transport of vitamins, nucleosides, and related molecules SLC35B3 SLC35B2 LCN9 SLC27A1 SLC35B4 SLC35D1 SLC35D2 SLCO1B1 SLC5A6 LCN15 SLCO2B1 LCN12 SLCO1B3 PDZD11 APOD SLC16A2 SLC35A2 SLC35A1 SLC35A3 SLC33A1 SLC35C1 SLCO1C1 ARL2BP SLCO4A1 SLCO2A1 SLCO1A2 SLCO4C1 LCN1 SLC29A4 SLC27A6 AVP SLC25A5 SLC28A2 SLC29A1 SLC28A1 ARL2 SLC25A4 SLC29A3 SLC25A6 SLC29A2 SLC28A3 SLC27A4 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 80%71064 Lysine catabolism OGDH PIPOX DLST SLC25A21 CRYM ALDH7A1 DLD PHYKPL AASS GCDH HYKK AADAT RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.1 RND3 GTPase cycle FAM83B ARHGAP5 DSP ANKRD26 VANGL1 ARHGAP35 DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F PTPN13 CKAP4 KTN1 PIK3R1 NISCH CCDC88A VANGL2 UBXN11 DLG5 CPD KCTD13 DSG1 PKP4 RBMX PICALM LEMD3 DEPDC1B EPHA2 PIK3R2 RASAL2 ARHGAP21 DDX4 ROCK1 TNFAIP1 RND3 MUC13 CAV1 FLOT2 WDR6 CKB GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 80%3229121 Glycogen storage diseases GYG2 SLC37A4 RPS27A GYG1 UBA52 EPM2A GBE1 GAA G6PC1 GYS2 UBB GYS1 G6PC3 PPP1R3C UBC NHLRC1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 80%8955332 Carboxyterminal post-translational modifications of tubulin TUBA1B TUBB2B TUBB2A TUBA3E TUBB6 TUBA3D TUBB3 TUBB1 TUBA3C TTLL10 TPGS1 TTL TPGS2 TUBB8 TUBA1A SVBP AGTPBP1 LRRC49 NICN1 TUBB8B VASH2 TUBB4B VASH1 TUBB4A TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 TTLL1 AGBL3 AGBL2 TTLL13 TTLL11 TTLL12 TTLL9 TUBA1C TTLL8 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%6787639 GDP-fucose biosynthesis GMDS FCSK FPGT FUOM GFUS SLC35C1 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702569 KW2449-resistant FLT3 mutants FLT3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 80%198323 AKT phosphorylates targets in the cytosol GSK3A BAD CASP9 MKRN1 AKT1S1 AKT3 CHUK GSK3B AKT2 MDM2 AKT1 CDKN1A CDKN1B TSC2 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.1 Sodium Proton exchangers SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.2 IRF3 mediated activation of type 1 IFN ZBP1 NLRP4 DTX4 TBK1 IRF3 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 80%2871796 FCERI mediated MAPK activation IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MAPK1 IGKV3-15 IGKV3-11 MAPK3 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 PAK1 V1-3 IGKV3D-20 V5-6 RAC1 IGHE IGLV3-19 PAK2 VAV1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 NRAS IGHV3-48 IGLV3-25 PLCG1 IGLV3-27 SOS1 IGKC HRAS IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 VAV2 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 GRAP2 MAP2K4 PLCG2 MAP2K7 JUN VAV3 SYK FOS LCP2 MAPK9 MAPK8 MAPK10 MAP3K1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME DATABASE ID RELEASE 80%9027283 Erythropoietin activates STAT5 EPO IRS2 STAT5A EPOR LYN STAT5B JAK2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME%R-HSA-442660.1 Na+ Cl- dependent neurotransmitter transporters SLC6A19 SLC6A18 SLC6A15 SLC22A2 SLC22A1 SLC6A14 SLC6A13 SLC6A12 SLC6A11 SLC6A20 SLC6A1 SLC6A2 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9 SLC18A1 SLC18A2 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME DATABASE ID RELEASE 80%6803207 TP53 Regulates Transcription of Caspase Activators and Caspases TP63 TP73 ATM PIDD1 APAF1 CRADD CASP6 CASP10 CASP1 TP53 CASP2 NLRC4 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.2 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 SEC13 NUP133 SRC DLG4 AAAS CALM1 NUP160 NUP85 NUP43 RANBP2 DDX4 ROCK1 TNFAIP1 RND3 MUC13 FLOT2 NUP37 WDR6 CKB FAM83B DSP ANKRD26 DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F PLD1 PTPN13 PLD2 CKAP4 KTN1 NISCH CCDC88A VANGL2 UBXN11 DLG5 CPD KCTD13 DSG1 PKP4 RBMX PICALM MTR SRRM1 DDX39B VAV3 YWHAE CCP110 PPP1CB PPP2R1A YWHAG HSP90AA1 PPP1R12A CYFIP2 ITSN2 ANKLE2 DYNLL1 WIPF1 CKAP5 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MYLK MAPRE1 PREX2 GJA1 WDR91 EPSTI1 ANKFY1 CEP97 PAFAH1B1 FNBP1 DYNC1I2 STARD8 PRKCD MRTFA FRS2 FRS3 AR DYNC1LI1 DYNC1LI2 MYL6 DAAM1 WDR81 MYL9 NGEF MTMR1 SHMT2 CDCA8 IQGAP1 IQGAP2 PRKCZ CLASP1 IQGAP3 SKA1 SKA2 DYNC1H1 RHOT2 RHOT1 NDE1 MYO6 SFN PLK1 HMOX2 STARD13 JUP FAM135A HNRNPC CDC42SE2 ARHGAP9 ARHGAP8 ARPC1B ARPC1A OSBPL11 LRRC1 ARHGAP4 NUF2 NUDC RRAS2 GMIP DYNLL2 LRRC41 CIT INCENP PRKCA CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 PLIN3 PKN3 GPS1 FGD1 FGD2 FGD3 FGD4 PRKCB FGD5 YWHAB CHN2 CHN1 FLNA STX5 FARP2 FARP1 KIDINS220 WWP2 DEF6 WDR11 LETM1 TMEM59 CENPF TAOK1 SHKBP1 PKN2 GOPC FILIP1 PKN1 UHRF1BP1L FAM13B PLXND1 FAM13A MSI2 PPP1CC STK10 SLK CFL1 POTEE MEN1 GOLGA8R LAMTOR1 TPM4 TPM3 RALGAPA1 CDC25C FAM91A1 TEX2 ARMCX3 CLIP1 OBSCN ITGB1 NCKAP1 PHIP CYFIP1 MAD1L1 TRIO RHOBTB3 NCF1 LIN7B TFRC RHOBTB1 NCF2 RHOBTB2 STIP1 SNAP23 NCF4 DDRGK1 ARHGAP1 DVL1 STK38 BRK1 DVL2 ARHGAP39 ARHGAP5 PLXNA1 ARHGAP6 DVL3 SRGAP3 ARHGAP35 SRGAP1 DOCK10 ARPC4 SYDE1 PREX1 ARPC5 NDC80 ARHGAP42 COPS4 BAIAP2L1 NSFL1C OPHN1 ARPC2 STBD1 ARPC3 ARHGDIB COPS2 PIK3R1 RAC3 EMD PLXNB1 NF2 LBR MAP3K11 GIT1 ARHGAP11A PIK3CA TMPO SWAP70 ZNF512B CDC37 ARHGAP11B ARAP2 RASGRF2 SOS1 CYBB TAGAP ARAP3 EFHD2 CYBA NCK2 OCRL VRK2 SPDL1 LEMD3 NCK1 ACTR3 VAV2 BCR PLEKHG3 ACTR2 TIAM1 DEPDC1B PLEKHG4 RAPGEF1 PLEKHG1 CDC42EP1 CDH1 PLEKHG2 PLEKHG6 DSG2 ARFGAP3 RAB7A RANGAP1 EPHA2 VAMP3 NIPSNAP2 ARFGAP2 GARRE1 BIRC5 AMIGO2 PIK3C3 NOXO1 EVL PIK3R2 PPP1R12B ARHGAP17 SOS2 SLC1A5 ROCK2 ARHGAP15 LMAN1 SRF ABR NSL1 PARD6B ARHGAP21 PARD6A PGRMC2 ARL13B RACGAP1 SH3BP1 SLITRK3 NHS CSK ABL2 RBBP6 SLITRK5 WHAMM NCKAP1L WASF3 WASF1 RNF20 SRGAP2 PPP1R14A WASF2 NDUFA5 YKT6 PCDH7 KLK2 CDC42BPB PAK4 CDC42BPA IL32 MYO19 GIT2 JAG1 PRC1 CPNE8 CAV1 MCAM GOLGA3 MCF2 BAIAP2L2 ACTN1 ARHGAP26 BAIAP2 TIAM2 ZW10 MPP7 VANGL1 SPATA13 BTK ARHGAP32 PFN1 DIAPH3 TAOK3 CFTR ABI2 ROPN1 ABI1 PFN2 NOXA1 GRB7 NOX3 TMEM87A PIK3R4 ESYT1 NOX1 PIK3R3 FERMT2 TWF1 KLK3 KALRN S100A9 MYL12B S100A8 DSN1 SCFD1 SCAI SPTBN1 RCC2 STAM ZWINT PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 WASL USP9X SH3RF1 AKAP12 AKAP13 XPO1 HINT2 SH3PXD2A RAC2 SPTAN1 NDEL1 NCOA2 CCDC115 RHOG RHOH RHOF RHOC RHOD RHOB PPP2R5D ARHGEF9 CTTN RHOJ ARHGEF3 PPP2R1B ARHGEF4 RHOU ARHGEF1 TAX1BP3 ARHGEF2 RHOV ARHGEF7 RHOQ DBN1 ARHGEF5 ARHGEF6 C1QBP MIS12 WAS TRAK1 TRAK2 SAMM50 PLEKHG4B H2AX EMC3 CTNNA1 H2AB1 H2AC19 PAK6 DYNC1I1 PAK5 H2AC14 BCAP31 H2BC12L CAVIN1 MTX1 MYO9B H2BC21 MYO9A DLC1 H2BU1 TRIP10 RAB9A H2AC8 B9D2 H2AC6 RAB9B H2AC7 KNL1 SPC24 SPC25 H2BC17 ERCC6L H2BC12 STEAP3 H2BC13 RTKN H2BC14 H2AJ PRAG1 ZWILCH H2BC15 ARHGDIG H2BC11 ACTG1 ITGB3BP CENPA SYDE2 CENPC ARHGAP44 ARHGAP40 BASP1 H2AZ1 KNTC1 H2BC9 ARHGEF40 CENPT RALBP1 H2AZ2 KCTD3 CENPU ARHGAP45 SGO1 H4C9 ALDH3A2 H2BC8 SGO2 ELMO2 STAM2 H2BC5 ARHGEF26 H2BC3 ARHGEF25 ARHGEF28 H2BC1 ARHGAP19 ARHGAP18 CENPH PMF1 CENPI TOR1AIP1 H2AC20 ARHGAP12 CENPK NCKIPSD CENPL ARHGAP22 CENPM ARHGAP20 CENPN RHPN1 CENPO MYH14 CENPP MYH11 CENPQ RHPN2 CENPS ECT2 MYH10 CPSF7 ACBD5 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 DIAPH2 ARHGAP31 DNMBP ARHGAP30 SOWAHC ARHGEF10L RND2 RND1 LMNB1 YWHAQ MCF2L DBT FLOT1 YWHAH ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 ARAP1 YWHAZ SENP1 ZAP70 ARHGAP10 ALS2 GFOD1 PEAK1 NDUFS3 CCDC187 RAP1GDS1 MOSPD2 ADD3 FAM169A UACA AURKB GNA13 TRA2B PTK2B STOM VHL BUB1 CLASP2 RPS27 SPEN KDM4C LIMK2 LIMK1 HSPE1 SLC4A7 FMNL3 MAPK11 FMNL1 FMNL2 ACTC1 VIM H3-3B PDPK1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C PDE5A MAPK14 CUL3 RASAL2 KDM1A DOCK11 KIF5B KIF5A HSP90AB1 KLC1 KLC4 KLC3 KLC2 ABL1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 DOCK7 CAPZB PIN1 H3C8 CDKN1B KIF2A KIF2C KIF2B DOCK2 DOCK1 H3C15 MFN1 MFN2 CCNE1 CENPE PPP2CA PPP2CB MAPK1 CTNNB1 MAPK3 HGS CDC42 CLTC PAK1 LCK RAC1 PAK3 PAK2 VAV1 VCP ARHGDIA RHOA BUB1B CDC20 BUB3 MAD2L1 MYH9 ACTB CCT6A VAPB TUBA1B CCT2 CCT7 ERBIN NUP107 ATP6AP1 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.3 Collagen chain trimerization COL11A1 COL11A2 COL10A1 COL9A1 COL28A1 COL9A3 COL27A1 COL9A2 COL18A1 COL24A1 COL14A1 COL22A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL5A3 COL4A4 COL7A1 COL5A2 COL6A1 COL4A3 COL8A2 COL16A1 COL4A6 COL12A1 COL20A1 COL6A3 COL8A1 COL4A5 COL21A1 COL6A6 COL6A5 COL25A1 COL23A1 COL15A1 COL17A1 COL13A1 COL19A1 COL26A1 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 80%5684264 MAP3K8 (TPL2)-dependent MAPK1 3 activation IKBKB MAP3K8 RPS27A IKBKG CHUK UBA52 NFKB1 BTRC SKP1 CUL1 MAP2K4 FBXW11 UBB MAP2K1 TNIP2 UBC TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 80%190827 Transport of connexins along the secretory pathway GJB2 GJB1 GJA1 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 80%3928663 EPHA-mediated growth cone collapse YES1 RHOA LYN FYN ROCK2 MYL12B MYH9 MYH14 MYH11 ROCK1 MYH10 MYL6 MYL9 NGEF AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.2 Amine ligand-binding receptors TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C HTR5A TAAR1 ADRA2B ADRA2A GPR143 ADRB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRA1D ADRB2 HTR2A HTR4 ADRA1B ADRA1A TAAR3P HTR6 HRH1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 TAAR8 HTR1E SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 80%190236 Signaling by FGFR KLB FGFRL1 TIAL1 PTBP1 FGFBP3 FGFBP1 RBFOX2 FGFBP2 GTF2F1 GTF2F2 HNRNPH1 ESRP2 ESRP1 ANOS1 FLRT2 FLRT3 SPRED2 FLRT1 BRAF SPRED1 PPP2CA HNRNPA1 PPP2CB TIA1 MKNK1 GALNT3 MAPK1 HNRNPM FGF19 SPRY2 MAPK3 HNRNPF FGFR4 PPP2R1A FGF16 FGF7 FGF18 GAB1 UBA52 PIK3R1 CBL NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 POLR2A FRS3 POLR2B FGF1 POLR2C FGF2 POLR2D FGF3 FGF4 UBB POLR2E FGF6 POLR2F FGF9 POLR2G FGF20 POLR2H UBC POLR2I FGF23 POLR2J FGF22 POLR2K FGF10 RPS27A POLR2L NCBP1 NCBP2 PTPN11 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.3 SUMOylation of immune response proteins NFKBIA IKBKE RELA SUMO3 NFKB2 UBE2I PIAS4 PIAS3 SUMO1 TOPORS IKBKG TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 80%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 80%180534 Vpu mediated degradation of CD4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CD4 PSMB1 PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 UBB UBC RPS27A REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 80%3248023 Regulation by TREX1 TREX1 PHENYLKETONURIA%REACTOME%R-HSA-2160456.2 Phenylketonuria PAH NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 80%194441 Non-coding RNA Metabolism NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 GEMIN2 PHAX SNRPD2 SNRPD1 NUP155 SNRPD3 PRMT5 WDR77 CLNS1A GEMIN4 SNRPG NUP153 GEMIN5 GEMIN6 SNRPE GEMIN7 SNRPF GEMIN8 NUP35 SNRPB NUP37 DDX20 TGS1 SMN2 SNUPN NCBP1 NCBP2 NUP107 NUP188 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 80%5250941 Negative epigenetic regulation of rRNA expression HDAC2 H3C15 CCNH HDAC1 SUV39H1 SIN3A H2AX ARID4B H3-3B H2AB1 TTF1 H2AC19 RRP8 SIN3B SAP130 H2AC14 UBTF H2BC12L DNMT3B SAP30BP H2BC21 TBP SIRT1 SAP30 H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 DNMT1 H2AJ BAZ2A H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E SAP30L POLR2F TAF1A SAP18 POLR2H SUDS3 H2AZ1 MBD2 POLR2K H2BC9 CDK7 POLR2L MNAT1 H2AZ2 GTF2H1 H4C9 H2BC8 GTF2H2 GTF2H3 GTF2H4 H2BC5 GTF2H5 H2BC3 SMARCA5 H2BC1 ERCC3 H2AC20 ERCC2 H3C8 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 80%2046106 alpha-linolenic acid (ALA) metabolism FADS2 ELOVL1 ACOT8 SCP2 ACSL1 ELOVL5 ELOVL2 ELOVL3 HSD17B4 ACAA1 ABCD1 FADS1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) UBAP1 CHMP4A CHMP6 CHMP7 VPS25 VPS28 CHMP5 UBA52 STAM UBB UBC RPS27A STAM2 HGS TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A SNF8 VPS37B CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 80%5619060 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME%R-HSA-5579004.2 Defective CYP26C1 causes FFDD4 CYP26C1 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 80%5657562 Essential fructosuria KHK INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.3 Influenza Viral RNA Transcription and Replication RPS11 RPS10 RPL39 RPS13 RPS12 NUP62 NUP214 RPS9 RPL21 NDC1 RPS7 RPS8 SEC13 NUP210 RPS5 RPL23 IPO5 RPL22 NUP133 GRSF1 PARP1 RPL13A RPSA DNAJC3 RPS3A RPL9P9 NUP93 RPL37A RPL24 RPL27 NUP50 RPL26 NUP54 RPL29 RPL28 NUP205 POM121 RPS4Y2 RPL10 AAAS RPL12 RPS6 NUP160 RPL11 RPL36A RPS27L RPS4Y1 POM121C RPS15A NUP42 RPL14 NUP85 RPS3 RPL13 RPS2 TPR RPL15 NUP88 RPL18 NUP43 RPL17 RAE1 RPL19 RPL39L RANBP2 RPL41 RPL35A RPL23A NUP155 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 NUP153 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 NUP35 RPS23 NUP37 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSP90AA1 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL NUP107 RPS18 NUP188 RPL36 RPL35 RPLP2 RPL38 RPL37 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.1 Mitochondrial translation elongation MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPS21 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPL43 MRPS5 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPS33 MRPL18 MRPL19 MRPS34 MRPS31 MRPL16 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 80%113418 Formation of the Early Elongation Complex CCNH POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 SUPT5H ERCC3 ERCC2 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.4 Viral Messenger RNA Synthesis NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 POLR2A NUP50 POLR2B GTF2F1 NUP54 POLR2C GTF2F2 NUP205 POLR2D POM121 POLR2E POLR2F AAAS POLR2G NUP160 POLR2H POLR2I POLR2J POLR2K POM121C POLR2L NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.2 G1 S DNA Damage Checkpoints PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME4 PSME1 CCNE1 PSME2 PSMD10 CDK2 PSMB11 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PHF20 PSMB9 CHEK2 ZNF385A SEM1 COP1 CDKN2A PSMC5 PCBP4 PSMC6 PSMC3 MDM2 PSMC4 MDM4 PSMC1 ATM PSMC2 CCNA2 CCNA1 UBA52 UBB UBC RPS27A CHEK1 CDC25A CDKN1A CDKN1B INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.2 Inhibition of TSC complex formation by PKB TSC1 AKT2 TSC2 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.2 ARL13B-mediated ciliary trafficking of INPP5E PDE6D ARL13B INPP5E SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 80%1660516 Synthesis of PIPs at the early endosome membrane PIK3C3 PIK3R4 VAC14 PI4K2B MTMR10 MTMR2 MTMR12 MTMR4 PIK3C2A MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.2 Activation of the TFAP2 (AP-2) family of transcription factors CITED2 TFAP2A CITED4 TFAP2B YEATS4 WWOX TFAP2C TFAP2D EP300 TFAP2E CREBBP CITED1 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 80%2219530 Constitutive Signaling by Aberrant PI3K in Cancer IRS1 PIK3CD FLT3 PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG GAB2 PIK3R3 MET PDGFB SRC TGFA KLB CD19 NRG1 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 IRS2 RAC2 FGF19 FGFR4 RHOG FGF16 FGF7 FGF18 KIT CD86 LCK CD80 CD28 FYN RAC1 EGF GAB1 VAV1 PIK3R1 EGFR PIK3CA FRS2 BTC NRG3 FGF1 NRG4 FGF2 NRG2 FGF3 HBEGF FGF4 EREG FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 PIK3R2 ERBB2 PTPN11 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.1 Triglyceride metabolism GPAT2 PLIN3 GPAM GK3P MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK2 LPIN1 LIPE LPIN2 AGMO LPIN3 GK PRKACG FABP9 PRKACB PPP1CA FABP1 FABP2 FABP3 PPP1CB FABP4 PPP1CC FABP5 FABP6 FABP7 PNPLA4 PNPLA5 PLIN1 DGAT2 PRKACA DGAT1 MGLL GPD2 CAV1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.3 Attachment and Entry GPC2 GPC5 GPC4 AGRN GPC6 TMPRSS2 HSPG2 ACE2 VCP CTSL FURIN SDC4 SDC2 SDC3 GPC1 GPC3 SDC1 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 80%447041 CHL1 interactions CHL1 CNTN6 ITGA2 ITGA10 ITGA1 ITGB1 ANK1 HSPA8 NRP1 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.1 Sensory perception of salty taste SCNN1G CALHM1 SCNN1D SCNN1B SCNN1A CALHM3 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 80%6791312 TP53 Regulates Transcription of Cell Cycle Genes E2F1 PCNA TFDP1 CCNE2 TFDP2 EP300 CCNE1 CDK2 TP53 BAX CDC25C ZNF385A PCBP4 BTG2 TNKS1BP1 CNOT6L PRMT1 RBL2 RBL1 PLAGL1 E2F4 E2F7 E2F8 PLK3 GADD45A CCNA2 ARID3A CCNA1 CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT1 CNOT11 CARM1 CNOT2 CNOT3 CNOT8 CNOT9 AURKA CCNB1 NPM1 SFN PLK2 CENPJ CDK1 CDKN1A CDKN1B BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 80%1307965 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 80%4085023 Defective GFPT1 causes CMSTA1 GFPT1 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.1 Estrogen-dependent nuclear events downstream of ESR-membrane signaling XPO1 MAPK1 CCND1 MAPK3 AREG EGF SRF AKT3 TGFA EGFR EPGN AKT2 FOXO3 BTC ELK1 PTK2 AKT1 UHMK1 CREB1 BCL2 HBEGF EREG CDKN1B FOS MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.2 Maturation of nucleoprotein PARP14 PARP8 GSK3B UBE2I GSK3A SUMO1 PARP10 PARP6 PARP4 PARP16 PARP9 PURINE SALVAGE%REACTOME%R-HSA-74217.5 Purine salvage GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP HPRT1 ADA SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 80%9649948 Signaling downstream of RAS mutants CNKSR1 FGB KRAS FGA TLN1 VWF RAF1 VCL CAMK2B FGG CAMK2D YWHAB SRC CAMK2A NRAS MAP3K11 HRAS CALM1 CAMK2G MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 PHB1 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.1 Heparan sulfate heparin (HS-GAG) metabolism HPSE2 XYLT2 XYLT1 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 NDST1 NAGLU NDST4 NDST3 IDS GUSB HS3ST3B1 GLCE B4GALT7 HS3ST3A1 IDUA B3GAT3 B3GAT2 B3GAT1 HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 EXT2 DCN HPSE GLB1L GLB1 SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 GPC5 CSPG4 GPC4 AGRN GPC6 HSPG2 BCAN POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 80%163125 Post-translational modification: synthesis of GPI-anchored proteins GPIHBP1 PIGS LY6K CPM PIGU PGAP1 PIGT PIGO PSCA PIGN GPAA1 PIGP PIGZ MSLN PIGW PIGV PIGY PRSS21 PIGX FCGR3B PRND TECTA TECTB CD52 PLAUR IZUMO1R RTN4RL2 PIGC DPM1 DPM2 PIGB DPM3 CEACAM7 NRN1L RTN4RL1 CEACAM5 CD109 PIGA LY6D PIGK PIGM SPACA4 PIGL PIGG LY6H VNN1 PIGF VNN2 GPLD1 PIGH LY6E NRN1 NTM TEX101 LYPD1 LYPD2 ALPI LYPD3 LYPD4 THY1 LYPD5 ART3 ART4 LYPD8 OTOA LY6G6C LY6G6D OPCML NTNG1 NTNG2 CNTN5 NEGR1 LSAMP GP2 PLET1 BST1 PRSS41 XPNPEP2 RAET1G LYPD6B RAET1L ALPL CNTN3 MELTF CNTN4 FOLR2 ULBP2 MDGA2 ALPG RECK MDGA1 SPRN INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 80%9006925 Intracellular signaling by second messengers INSR BMI1 CAMK2B RING1 CAMK2D SRC CAMK2A NRG1 CALM1 CAMK2G RNF2 HDAC7 CBX8 PHC2 PHC1 CSNK2A1 CBX4 CSNK2A2 CBX2 PHC3 PML CSNK2B PDPK1 TRAF6 BTC NRG3 NRG4 NRG2 HBEGF EREG PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PRKAR2A PPP2R5E GSK3B PPP2R5B PPP2R5A ATF2 PPP2R5C AHCYL1 PIP4K2A PIP4K2B ADCY4 TRIM27 PIP4K2C ADCY3 IER3 ADCY2 PRKCE ADCY1 TRIB3 ADCY8 PDE1C PDE1B ADCY7 FLT3 PDE1A MAPKAP1 ADCY6 GSK3A PIP5K1A ADCY5 ITPR1 BAD PIP5K1B ITPR2 CASP9 PIP5K1C ITPR3 MKRN1 AKT3 EGR1 MOV10 SNAI1 SNAI2 EZH2 MECOM KLB PPARG PHLPP2 PHLPP1 XIAP PRKX CAMKK1 CAMKK2 RICTOR MBD3 SUZ12 GATAD2B JUN IL33 GATAD2A RNF146 IL1RL1 TP53 NEDD4 FRK ATN1 SALL4 MAF1 KPNA2 TNKS IRS2 FOXO6 IRAK1 FGF19 FOXO4 AGO3 FOXO1 FGFR4 GRK2 AGO4 THEM4 PPP2R1A AGO1 CBX6 AGO2 NR4A1 NBEA MYD88 PRR5 PRKACA PTEN CHD4 CHD3 NR2E1 EED IRAK4 USP13 KDM1A HDAC5 MTA1 TNKS2 MTA2 MTA3 TNRC6C REST RPS6KB2 STUB1 TNRC6A OTUD3 TNRC6B PREX2 UBA52 PRKCD FRS2 FGF1 FGF2 FGF3 FGF4 UBB FGF6 PRKAR2B FGF9 FGF20 UBC FGF23 FGF22 FGF10 RPS27A RCOR1 PTPN11 CDKN1A CDKN1B PSMD8 PRKCG PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 CHUK PSMA5 PSMA6 HDAC2 PSMA3 RPTOR PSMA4 PSMA1 PSMA2 AKT2 PSME3 PSME4 WWP2 MLST8 PSME1 AKT1 PSME2 SLC38A9 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 TSC2 PSMA7 PPP2CA PPP2CB MTOR PSMB10 MAPK1 PSMA8 RRAGA PSMB6 MAPK3 RRAGC PSMB7 PSMB4 PSMB5 RHEB RRAGB PSMB2 PSMB3 AKT1S1 RRAGD PSMB1 PSMF1 LAMTOR2 LAMTOR1 PSMB8 LAMTOR4 PSMB9 LAMTOR3 LAMTOR5 SEM1 PSMC5 PSMC6 PSMC3 MDM2 PSMC4 PSMC1 KIT PSMC2 HDAC3 CD86 HDAC1 CAMK4 LCK CD80 CD28 FYN RAC1 EGF GAB1 PIK3R1 VAV1 EGFR PIK3CA PLCG1 PIK3R2 IRS1 PIK3CD PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG PIK3R3 GAB2 MET PDGFB TGFA CD19 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 USP7 RAC2 RHOG FGF16 FGF7 FGF18 PPP2R5D PPP2R1B FOXO3 CREB1 RBBP4 RBBP7 ERBB2 INS SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 80%5655302 Signaling by FGFR1 in disease BAG4 ZMYM2 CUX1 FGFR1OP2 MYO18A TRIM24 LRRFIP1 CPSF6 STAT1 ERLIN2 GAB1 GAB2 FGFR1 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FGF1 FGF2 BCR FGF4 FGF6 FGF9 FGF20 FGF23 STAT3 CEP43 STAT5A STAT5B TIE2 SIGNALING%REACTOME%R-HSA-210993.1 Tie2 Signaling PIK3CB PIK3R2 GRB7 SHC1 ANGPT4 PIK3R1 ANGPT2 ANGPT1 DOK2 NRAS GRB14 PIK3CA TEK SOS1 HRAS PTPN11 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-HSA-8941855.1 RUNX3 regulates CDKN1A transcription SMAD4 TGFB1 ZFHX3 SMAD3 RUNX3 CDKN1A TP53 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 80%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex TAB3 RPS27A TAB2 TAB1 TICAM1 TLR3 TRAF6 UBB MAP3K7 UBA52 UBC INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.1 Interleukin-12 signaling CDC42 TCP1 PAK2 P4HB LMNB1 ARF1 RALA PSME2 PITPNA BOLA2B CNN2 CA1 HNRNPDL CAPZA1 STAT4 IL12B IL12A IL12RB1 IL12RB2 JAK1 HSPA9 SERPINB2 ANXA2 HNRNPF GSTO1 AIP MSN CFL1 TYK2 IL10 MIF RPLP0 SOD2 SOD1 MTAP VAMP7 IFNG GSTA2 HNRNPA2B1 PDCD4 SNRPA1 LCP1 PPIA RAP1B TALDO1 JAK2 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.2 ASP-3026-resistant ALK mutants ALK DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.3 Defective ABCC2 causes DJS ABCC2 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.2 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 80%111932 CaMK IV-mediated phosphorylation of CREB KPNA2 CAMK4 CAMKK1 CAMKK2 CAMK2B CREB1 CAMK2D CALM1 CAMK2G CAMK2A RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 80%73854 RNA Polymerase I Promoter Clearance HDAC2 H3C15 KAT2B KAT2A MBD3 GATAD2B GATAD2A MAPK3 CHD4 CHD3 MTA1 MTA2 MTA3 CCNH HDAC1 H2AX H3-3B H2AB1 TTF1 H2AC19 H2AC14 UBTF H2BC12L H2BC21 TBP H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 H2AJ H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E POLR2F TAF1A RBBP4 POLR2H RBBP7 H2AZ1 MBD2 POLR2K H2BC9 CDK7 POLR2L MNAT1 H2AZ2 GTF2H1 H4C9 H2BC8 GTF2H2 GTF2H3 GTF2H4 H2BC5 GTF2H5 H2BC3 H2BC1 ERCC3 H2AC20 ERCC2 EHMT2 RRN3 CBX3 H3C8 ERCC6 ERK MAPK TARGETS%REACTOME%R-HSA-198753.1 ERK MAPK targets PPP2CA RPS6KA2 PPP2CB RPS6KA1 MAPK1 MAPK3 PPP2R1A DUSP4 DUSP3 PPP2R5D VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B ELK1 MAPK14 MAPK11 MEF2A MEF2C RPS6KA3 RPS6KA5 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 80%446652 Interleukin-1 family signaling IKBKB PSMD8 IL1RN PSMD9 PSMD6 IL18RAP PSMD7 IL36A PSMD4 IL36B PSMD5 IL1R1 PSMD2 IL1R2 PSMD3 SIGIRR PSMD1 SQSTM1 IL36RN IKBKG MAP3K7 MAP2K6 GSDMD CHUK IL36G IL1F10 PSMA5 IL4 PSMA6 TOLLIP PSMA3 PTPN20 PSMA4 PTPN23 PSMA1 IL18BP PSMA2 PSME3 UBE2V1 RIPK2 PSME4 IL13 PSME1 IL18 PSME2 IRAK3 IL1A PSMD10 IL1B IL1RAPL1 PSMB11 PSMD12 NOD1 PSMD11 NOD2 PSMD14 IL1RL2 PSMD13 ALOX5 MAP3K3 PSMA7 PTPN18 RELA IL37 PTPN12 PSMB10 PTPN14 PSMA8 PTPN9 PSMB6 PTPN7 PSMB7 PTPN4 PSMB4 PTPN5 PSMB5 IL18R1 PSMB2 PTPN2 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 UBE2N TAB3 PSMC5 TAB2 PSMC6 TAB1 PSMC3 PSMC4 PSMC1 PSMC2 NFKBIB TBK1 TRAF6 PTPN13 MAP2K1 TNIP2 MAP3K8 IRAK2 CTSG MAP2K4 IL33 IL1RL1 MAPK8 PTPN6 IRAK1 PELI3 PELI2 PELI1 MYD88 BTRC SMAD3 IRAK4 SKP1 FBXW11 CASP1 APP HMGB1 UBA52 NKIRAS1 NKIRAS2 CUL1 UBB UBC RPS27A AGER STAT3 S100A12 S100B NFKB2 SAA1 PTPN11 RBX1 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 80%8963888 Chylomicron assembly MTTP APOA2 APOC3 SAR1B APOA1 APOA4 APOC2 P4HB APOE APOB DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.1 Defective CYP1B1 causes Glaucoma CYP1B1 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME%R-HSA-168316.3 Assembly of Viral Components at the Budding Site CANX CALR TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.2 Transcriptional regulation of granulopoiesis E2F1 H3C15 TFDP1 TFDP2 EP300 CDK4 CDK2 MYC LEF1 SPI1 CSF3R IL6R RUNX1 TAL1 RARA CEBPA CEBPB KMT2A CBFB CEBPE RXRA DEK FLI1 KLF5 MYB H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L GATA2 H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ CREB1 H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 STAT3 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDKN1A H3C8 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 80%1266738 Developmental Biology TLN1 PCGF2 EIF4A3 CASC3 MAGOH NCBP1 NCBP2 RBM8A PIP5K1C UPF3B MAGOHB EZH2 PPARG RNPS1 SUZ12 SALL4 FOXO1 EED TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 DOK2 SMAD4 PITPNA FGF2 FGF9 FGF10 MSN MEF2A MEF2C RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 PRKCA MAP2K6 AKT2 AKT1 RPS6 SPI1 CSF3R IL6R RUNX1 TAL1 RARA EIF4G1 CEBPA TGFB1 CEBPB KMT2A ITGB1 CBFB CEBPE RXRA TRIO DEK FLI1 KLF5 LIPJ DPYSL4 DPYSL5 DPYSL2 DPYSL3 LIPN ARHGAP39 LIPM LIPK MEF2B ARHGAP35 UNC5A UNC5B UNC5C UNC5D ISL1 RFX6 FLG DHH KRTAP27-1 AGAP2 KRTAP5-10 KRTAP5-11 GIT1 PPARGC1A KRTAP16-1 NR2F2 L1CAM PBX1 NANOG MED19 CTCF MED16 MED15 VAV2 MED18 MED17 TIAM1 MED12 CASP14 MED11 MED14 DSG2 MED13 MED10 EPHA2 MYOG UPF2 LYPLA2 LEFTY1 MED27 PIK3R2 MED26 POU5F1 MED29 MED28 MED23 MED22 MED25 MED24 MED21 MED20 PPARA ABL2 DSCAML1 KRTAP25-1 ADAM22 ADAM23 SRGAP2 ZSWIM8 KRTAP2-4 KRTAP2-3 PAK4 ZNF467 KRTAP2-2 LEFTY2 KRTAP2-1 MEF2D WT1 PTF1A NAB1 NAB2 MSI1 YY1 ADIPOQ PIAS2 MAG PKP2 PKP1 PKP3 UTRN DSC1 DSC2 DSC3 KMT2D SHC3 KMT2C RAP1GAP MED30 MED31 CLTCL1 KRTAP4-4 KRTAP4-3 MBP KRTAP4-2 KRTAP4-1 KRTAP4-9 KRTAP4-8 KRTAP4-7 KRTAP4-6 KRTAP4-5 DRAP1 PTPRC CXCL12 PTPRA CNTNAP1 ITGAV NEO1 ADGRV1 SPTB ZNF638 ETF1 DSG3 ITGA5 DSG4 ITGA9 KRTAP29-1 NTN4 NTN1 NTN3 KRTAP6-2 MAPK7 KRTAP6-1 SRY MYO10 KRTAP6-3 NELL2 EPHB6 CCNC EPHB2 EPHB1 CER1 EPHB4 SCN1B SCN1A EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 FOXH1 ANK2 HNF1A ANK3 SHTN1 STX1B KCNQ2 KCNQ3 LORICRIN EPHA1 STX1A EPHA3 PAXIP1 EPHA10 EPAS1 EVPL GSPT2 GSPT1 RRAS ST8SIA4 PCK1 SCN3B SCN3A WWTR1 EGR2 ST8SIA2 KRTAP8-1 MED13L SMARCA4 RPL4 ARTN RPL5 CD24 RPL30 SCN2A RPL3 SCN2B RPL32 NRP2 RPL31 HNF4G RPL34 RPLP1 PPP3CB CD36 RPL10L RPLP0 NCOA1 CAP1 RPL10A FOXD3 RPL8 NCOA6 RPL6 NCOA3 RPL7 RGMB SREBF2 RPS4X RGMA RPS15 NR5A1 RPL7A ENAH RPS14 PABPC1 RPS17 YAP1 RPS16 RELN RPS19 PERP RPL18A CAP2 RPL36AL CD72 RPS18 KLK13 RPL36 KLK14 RPL35 RPLP2 GCK KLK12 RPL38 FOXA3 RPL37 FOXA2 RPS11 TGM1 RPS10 MPZ RPL39 SCN9A RPS13 NRTN RPS12 TGM5 RPS9 SH3GL2 RPL21 SPINK6 RPS7 SPINK5 RPS8 ADAM11 RPS5 POU3F1 RPL23 POU3F2 RPL22 DOK1 RPL13A TYROBP RPSA DOK4 RPS3A DOK5 RPL9P9 DOK6 SCN8A SPINK9 KRTAP23-1 CACNA1D RPL37A CACNA1C RPL24 CACNA1H RPL27 CACNA1G RPL26 SPTA1 RPL29 CACNA1I RPL28 ADGRG6 RPS4Y2 LELP1 CACNA1S RPL10 WNT1 RPL12 KRTAP12-1 RPL11 PRNP RPL36A RPS27L KRTAP12-3 KRTAP12-2 RPS4Y1 KRTAP12-4 RPS15A CNTN1 RPL14 CNTN2 RPS3 TCF4 RPL13 TCF3 RPS2 LDB1 RPL15 CHD9 RPL18 TCHH RPL17 ZIC3 RPL19 SCN5A RPL39L KRTAP10-1 RPL41 CELA2A RPL35A RPL23A DPPA4 MYOD1 SCN4A RPL3L SCN4B RPS26 SHANK3 RPS25 KRTAP21-2 RPS28 KRTAP21-3 RPS27 LAMA2 RPS29 RPL27A LAMA1 RPL22L1 CRMP1 HMGCR RPS20 ACVR1B FAU ACVR1C RPS21 SLIT1 RPL26L1 BNIP2 RPS24 SCN7A RPS23 SLIT3 SLIT2 PDLIM7 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 H3-3B KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 ACVR2B CFC1 ACVR2A MAPK12 MAPK13 KRTAP21-1 LCE1A LCE1B ALCAM SCN11A HOXA3 HOXA2 HOXA1 PRSS8 POLR2A HOXA4 POLR2B MED1 POLR2C KRTAP17-1 POLR2D MED8 MED9 POLR2E LCE1E POLR2F MED4 POLR2G SOX10 POLR2H LCE1F POLR2I MED6 POLR2J LCE1C POLR2K MED7 POLR2L LCE1D LCE2B LCE2C SCN10A LCE2A KRTAP4-11 HOXB4 HOXB3 HOXB2 HOXB1 HOXD1 PRDM14 ZSCAN10 HOXC4 NKX2-2 WNT10B CDK19 ST14 RDX UPF3A HOXD4 HOXD3 DAND5 RET RARG KRTAP26-1 CLTB ASH2L HIF3A LCE5A KRTAP1-5 ELOB KRTAP1-4 ELOC KRTAP1-3 TEAD1 KRTAP1-1 KRTAP15-1 TCF12 PAX4 PAX6 LCE6A RARB IVL LCE2D LCE3C LCE3D LCE3A LCE3B LCE3E LCE4A ZNF335 SEMA5A MAPK14 TNF CDH4 SALL1 CDH2 GRB10 KRTAP3-3 KRTAP3-2 PLXNC1 KRTAP3-1 RPTN SEMA6A SEMA6D CACNB1 CACNB2 CACNB3 CACNB4 IAPP SEMA7A CUL2 NEUROD1 PLXNA2 PI3 NKX6-1 PLXNA4 PLXNA3 MAFA CDK8 SMAD2 MAFB SMAD3 DAB1 LHX3 LHX2 PLXNB3 LHX4 LHX9 TREM2 MYB PAGR1 KRTAP5-3 WDR5 KRTAP5-2 KRTAP5-1 AMH KRTAP5-9 KRTAP5-8 KRTAP5-7 ZFPM2 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 GATA4 KRTAP19-1 KRTAP19-4 KRTAP19-3 GATA2 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 SMARCD3 CEBPD SEMA3A SEMA3E ABL1 CACNG8 ABLIM1 ABLIM2 ABLIM3 RBBP5 CACNG2 CACNG3 CACNG4 SPAG9 SEMA4A SEMA4D CYP51A1 CDK5 KLF4 KIF4B NFASC KIF4A LEP INSM1 RPS6KA4 SOX2 RPS6KA6 DAG1 SOX9 PTGDS CDON KRT4 KRT3 KRT2 KRT1 KRT8 EBF1 KRT7 KRT5 KRT9 KRTAP20-1 EZR KRTAP20-2 SPRR2E SPRR2F SPTBN4 SPRR2G SPTBN5 H3C8 KRTAP10-10 KRTAP10-11 KRTAP10-12 KLK5 KLK8 MYL12A KRT33B HELZ2 KRT33A SPRR2A SPRR2B SPRR2D SPTBN2 VASP CDSN SIAH2 SIAH1 GDF1 TDGF1 SPRR1A DOCK1 HDAC2 SPRR1B NODAL H3C15 ROBO2 SH3KBP1 KRT24 ADIRF KRT23 KRT20 ROBO1 KRT28 KRT27 KRT26 KRT25 PRX KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP9-2 MYC KRTAP9-1 KRT35 KRT34 LEF1 GFRA1 CTNNB1 KRT32 KRT31 GFRA3 GFRA2 KRTAP9-9 KRTAP9-8 GFRA4 KRT39 KRT38 KRT37 KRT36 SPRR3 CSTA CXCR4 AKAP5 DRP2 CTNNA2 DMRT1 SCD5 KRT13 KRT12 RANBP9 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 KRT14 CDK5R1 CLTC KRTAP24-1 NRCAM KRT6C CLTA KRT6B VLDLR KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 DSCAM KRTAP13-3 KRT79 KAZN KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 EFNA5 EFNA4 KRT40 EFNB2 SDCBP EFNB1 EFNB3 PSPN EFNA1 EFNA3 LIN28A EFNA2 GDNF RHOA FES MYF6 MYF5 KRTAP22-1 USP33 SLC2A2 SLC2A4 HJV KDM6A KRTAP11-1 DCC MYH9 DNM1 DNM2 DNM3 GAP43 THRAP3 DCX TDGF1P3 CDH15 KRT82 KRT81 KRT80 KRT86 KRT85 KRT84 KRT83 FAM120B NCAM1 LGI1 LGI4 LGI3 LGI2 PDX1 MEIS1 PMP22 APH1A PSENEN APH1B PSEN2 INS SRC GRIN2B GRIN1 DLG1 DLG3 DLG4 CSNK2A1 CSNK2A2 ROCK1 CSNK2B DSP DSG1 PKP4 AKT3 JUN VAV3 MAPK8 IRS2 PRKACA HSP90AA1 ITSN1 UBA52 AJUBA FRS2 MYL6 UBB MYL9 NGEF UBC RPS27A CLASP1 JUP ARPC1B ARPC1A PTPN11 RBX1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 FARP2 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 RELA PSMB10 PLXND1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CFL1 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NCOR2 HDAC3 NCOR1 PLXNA1 TBL1XR1 SRGAP3 SRGAP1 ARPC4 ARPC5 TBL1X SHC1 ARPC2 ARPC3 GAB1 PIK3R1 PLXNB1 EGFR NRAS PIK3CA PLCG1 SOS1 HRAS NCK2 NCK1 ACTR3 ACTR2 CAPNS1 CAPN1 EVL SOS2 ROCK2 ADAM10 PSEN1 NCSTN COL9A1 COL9A3 COL9A2 PFN1 PFN2 GRB7 LAMC1 PIK3R3 KALRN MYL12B SPTBN1 PTK2 WASL MMP2 MMP9 SPTAN1 NCOA2 RHOC RHOB FURIN ARHGEF7 LAMB1 H2AX CTNNA1 H2AB1 PAK6 H2AC19 PAK5 H2AC14 H2BC12L MYO9B H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ACTG1 RBBP4 RBBP7 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 ARHGEF28 H2BC1 H2AC20 MYH14 MYH11 MYH10 RND1 PRKCQ ARHGEF11 ARHGEF12 LYN CLASP2 LIMK2 LIMK1 MAPK11 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 COL6A3 COL4A5 COL6A6 COL6A5 MAP2K1 PRKACG PRKACB YES1 PRKAR2A GSK3B NUMB CREBBP NOTCH1 MAML2 ONECUT3 MAML1 ONECUT1 HNF1B RBPJ KAT2B KAT2A SNW1 EP300 HES1 MAML3 MAMLD1 NEUROG3 FLRT3 RASA1 TGS1 HSP90AB1 CDKN1A CCND3 E2F1 TFDP1 TFDP2 CDK4 CDK2 MAPK1 MAPK3 CDC42 PAK1 FYN RAC1 PAK3 PAK2 NCAN SDC2 GPC1 AGRN PPL LPL PCSK6 PIK3CD PIK3CB GAB2 MET ANGPTL4 ACTB FABP4 PLIN1 HSPA8 NRP1 CHL1 CNTN6 ITGA2 ITGA10 ITGA1 ANK1 CNOT6 CARM1 CNOT9 FOXO3 CREB1 STAT3 ERBB2 AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 ITGB3 ITGA2B MAP2K2 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.2 LGI-ADAM interactions LGI1 LGI4 LGI3 LGI2 ADAM11 STX1B STX1A CACNG8 ADAM22 ADAM23 CACNG2 CACNG3 CACNG4 DLG4 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.2 Defective CYP11B1 causes AH4 CYP11B1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 80%418555 G alpha (s) signalling events SRC AVP ITGB1 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADRB1 ADRB2 PRKAR2A HTR4 TAAR3P HTR6 GNAS HTR7 HRH2 PTGIR DRD1 DRD5 TAAR8 ADCY4 TAAR9 ADCY3 TAAR6 ADCY2 ADCY1 ADCY8 TAAR5 PDE1B ADCY7 PDE1A ADCY6 TAAR2 ADCY5 VIPR1 VIPR2 TAAR1 SCT RXFP1 PDE11A RXFP2 GPR176 ADRB3 CYSLTR2 GNAT3 PDE8B PDE8A PTGDR PDE2A LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB GPR83 GPR84 PDE10A CRHR1 CRHR2 GHRHR GRK3 MC2R CALCR GRK5 GRK6 GRK2 CGA IAPP GNG10 GPR15 MC1R PDE3A RLN2 ITGA5 RLN3 GNG12 GPR27 PRKACA GNG11 GLP1R GNG13 GPR25 PDE3B GPR20 GNB2 ADM PTH1R GNB1 MC4R GNB4 GPER1 PDE4A GNB3 INSL3 TSHB GPR39 GNB5 GPR32 FSHB PDE4D GLP2R GNGT1 AVPR2 PDE4C GPBAR1 GNGT2 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 GNG3 P2RY11 SCTR GNG2 GCG GNG5 TSHR GNG4 POMC GHRH PRKAR2B GNG7 ADM2 GNG8 MC5R PDE7B PDE7A VIP RAMP1 GPHB5 ARRB1 ARRB2 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME%R-HSA-3656225.1 Defective CHST6 causes MCDC1 CHST6 ACAN LUM OGN OMD KERA PRELP FMOD VITAMINS%REACTOME DATABASE ID RELEASE 80%211916 Vitamins CYP26C1 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP2R1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.2 Antigen processing: Ubiquitination & Proteasome degradation FBXO2 HERC2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 NEDD4L UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 CDC34 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 UBE2V1 FBXL7 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B GAN RNF138 RNF130 HUWE1 KLHL2 WWP1 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE2N VHL UBE3A UBE3B FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 SOCS3 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F KLHL25 SMURF2 SMURF1 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO32 FBXO30 FBXO31 KLHL20 UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 BLMH UBE2M TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 TRIM69 UNKL TRIM63 DTX3L PJA2 PJA1 TRAF7 THOP1 TRIM50 RNF34 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 ELOB RNF7 RNF4 ELOC ASB17 RCHY1 ASB18 FBXL22 ASB15 MKRN1 FBXL21P ITCH ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 NEDD4 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 CUL3 TRIM32 ASB3 ASB1 CUL2 MIB2 KBTBD7 BTRC SKP1 FBXW11 STUB1 UBE2D3 UBE2L6 HERC5 TRIM4 UBA52 CUL1 UBB UBC RPS27A UBA7 UBE2K RBX1 ANAPC10 LRRC41 ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SIAH2 SKP2 SIAH1 ANAPC7 PSMA5 UBE2C PSMA6 PSMA3 UBE2E1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MYLIP PRKN CDC20 RBBP6 UBA6 FBXO4 UBE2Z UBE2L3 FBXO6 UBE2Q2 UBE2H FBXW4 UBE2B SH3RF1 FBXW5 FBXW10 UBE2E3 UBE2G1 FBXW7 FBXW9 UBE2A UBE2G2 FBXW2 UBE2W UBE2R2 UBA1 FBXL3 FBXL5 LRR1 CCNF KEAP1 CBLB DCAF1 HERC4 HERC3 RNF115 RNF114 HERC1 TRIM21 UBE2D2 FBXO7 RNF111 UBE2D1 HERC6 FBXO9 WSB1 DISEASES ASSOCIATED WITH THE TLR SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 80%5602358 Diseases associated with the TLR signaling cascade IKBKB FGB FGA BTK HMGB1 IKBKG FGG CHUK S100A9 S100A8 TICAM1 TLR3 TRAF3 RELA UNC93B1 LY96 CD36 CD14 S100A1 MYD88 TIRAP NFKB1 TLR1 TLR10 NFKBIA TLR6 TLR5 TLR4 IRAK4 NFKB2 TLR2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.2 Downstream signaling of activated FGFR1 FGF22 FGF10 GAB1 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FLRT2 FLRT3 FGF20 FLRT1 FGF23 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 80%8939245 RUNX1 regulates transcription of genes involved in BCR signaling BLK ELF1 CBFB ELF2 PAX5 RUNX1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.1 Regulation of RUNX1 Expression and Activity TNRC6B CCND3 CCND2 CCND1 AGO3 AGO4 AGO1 AGO2 MOV10 SRC RUNX1 CDK6 CBFB PTPN11 PML TNRC6C TNRC6A ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.1 Association of TriC CCT with target proteins during biosynthesis KIF13A CCT3 CCT2 SPHK1 TCP1 USP11 GBA DCAF7 CCT6B CCNE2 AP3M1 FBXO4 CCNE1 LONP2 FBXO6 FBXW4 TP53 FBXW5 CCT8 FBXW10 CCT7 FBXW7 CCT5 FBXW9 CCT4 NOP56 FBXW2 ARFGEF2 XRN2 STAT3 GAPDHS FKBP9 CCT6A SKIV2L FBXL3 FBXL5 WRAP53 HDAC3 CIRCADIAN CLOCK%REACTOME%R-HSA-400253.3 Circadian Clock HELZ2 CREBBP EP300 PPP1CA AVP PPP1CB PPP1CC NCOA2 CHD9 BTRC SKP1 RXRA CRTC2 CRTC3 FBXL3 CRTC1 SERPINE1 BHLHE41 RORA NR3C1 RBM4 HDAC3 TGS1 DBP CSNK1D NCOR1 NAMPT TBL1XR1 SREBF1 CSNK1E CPT1A KLF15 CRY2 CRY1 TBL1X SIK1 CLOCK HIF1A ARNTL2 NPAS2 UBA52 ARNTL SIRT1 RAI1 NFIL3 SMARCD3 NOCT NRIP1 PPARGC1A CARM1 F7 NR1D1 PER2 PER1 BHLHE40 CUL1 MED1 CREB1 UBB UBC RPS27A NCOA1 NCOA6 PPARA ATF2 MEF2C MEF2D DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.2 Defective GSS causes GSS deficiency GSS FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-HSA-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands HEBP1 SAA1 ANXA1 MT-RNR2 FPR1 FPR3 FPR2 APP SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.3 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 GSD IA%REACTOME DATABASE ID RELEASE 80%3274531 GSD Ia G6PC1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.3 PLCG1 events in ERBB2 signaling PLCG1 ERBB2 EGF EGFR DEATH RECEPTOR SIGNALLING%REACTOME%R-HSA-73887.4 Death Receptor Signalling IKBKB USP21 CFLAR FAS RBCK1 SQSTM1 FGD1 IKBKG FGD2 MAP3K7 FGD3 ARHGEF10L CHUK FGD4 HDAC2 MCF2L RIPK2 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 RELA NFKB1 GNA13 NFKBIA TAB3 TAB2 TAB1 OBSCN TRIO HDAC3 HDAC1 PLEKHG5 PREX1 RAC1 TRAF6 VAV1 RASGRF2 SOS1 VAV2 TIAM1 PLEKHG2 NGFR ARHGDIA NGF RHOA SOS2 ABR ADAM17 PSEN1 SMPD3 SMPD2 NCSTN MCF2 TIAM2 MAG BAD KALRN CASP3 XIAP TNF NET1 VAV3 AKAP13 YWHAE MAPK8 IRAK1 OTULIN MYD88 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 ARHGEF6 CASP2 BAG4 TNFAIP3 ITSN1 CASP8 UBA52 CASP10 TRAF2 UBB ITGB3BP PRDM4 SPPL2B NGEF UBC TAX1BP1 SPPL2A TNFSF10 ARHGEF40 PRKCI RPS27A USP4 USP2 OMG CLIP3 NSMAF BEX3 APH1A MAGED1 PSENEN ARHGEF26 RTN4 APH1B PSEN2 BCL2L11 RIPK1 SHARPIN FADD ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 TNFRSF10B TNFRSF10A TNFRSF10D CYLD TRADD OTUD7B FASLG AATF RACK1 ECT2 TRAF1 SORCS3 TNFRSF1A BIRC2 ARHGEF39 BIRC3 RNF31 LINGO1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 80%168256 Immune System AGA HERC2 METTL7A CCL19 AOC1 NUP62 CCL22 NUP214 CCL20 NDC1 AGL CARD9 SEC13 ERP44 NUP210 HSPA1B HSPA1A NUP133 GHDC ATP8A1 EPX PYCARD CLEC5A DEFB119 PIAS1 DEFB118 NUP93 DEFB117 DEFB116 CD180 DEFB115 NUP50 TAP2 NUP54 DEFB114 TAP1 SP100 NUP205 DEFB113 POM121 DEFB112 DEFB110 CLEC4A AAAS CLEC4C NUP160 CLEC4D CLEC4E CLEC4G CSF1R POM121C BRI3 NUP42 HVCN1 NUP85 VTN CLEC7A NDN TPR SLC15A4 NUP88 ATP8B4 NUP43 CD160 RAE1 CLEC6A XAF1 RANBP2 EIF4G3 EIF4G2 FCGR1BP EIF4E3 NUP155 PTPN22 TREM1 KCNAB2 IL3RA EIF4E2 ITLN1 NUP153 PFKL CLEC2B PML IMPDH1 IMPDH2 MNDA FOLR3 NUP35 CLEC2D NUP37 B2M MUCL1 SLC11A1 CHIT1 PLPP5 PLPP4 PDE12 CD101 MAOA EBI3 MGST1 C4B_2 cd21 INPP5D SIGLEC16 SIGLEC15 PTPRN2 SIGLEC14 STK11IP SIGLEC12 SIGLEC11 SIGLEC10 IFNLR1 GDI2 GLIPR1 MANBA NME2 IL17RE IL17RC IL17RB IL17RA CEACAM3 CEACAM1 CEACAM6 ALDOC CEACAM8 ALDOA DNASE1L1 OPRD1 LILRA6 IFI6 EIF4A3 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 CXCR1 NCR3LG1 CXCR2 GLYCAM1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 BATF SIRPA PDIA3 CD300A KLRF1 ELMO1 CD300E DEFB130A CD300C DEFB130B KLRB1 DEFB131A C5AR2 C5AR1 CSF2RB CSF2RA DPP7 KLRC1 RAP1GAP2 HSPA5 KLRC2 HSPA6 DNAJC13 MAN2B1 KLRD1 ULBP1 ULBP3 CXCL8 CRISP3 SLC2A3 CXCL1 SLC2A5 CXCL2 HTN1 HTN3 HEBP2 NAPRT OPRM1 USP41 USP18 S1PR1 KLRG1 CMTM6 LTBR ABCE1 TRPM2 TRPC1 VNN1 PDZD11 FGF2 GNS CAB39 YWHAB AKT2 MLST8 AKT1 EIF4E MTOR FKBP1A LAMTOR2 LAMTOR1 LAMTOR3 EIF4G1 TGFB1 ITGB1 NCKAP1 CYFIP1 NCF1 NCF2 SNAP23 NCF4 BRK1 STBD1 CYBB CYBA VAV2 RAPGEF1 RAB7A VAMP3 PIK3R2 RACGAP1 ABL2 NCKAP1L WASF1 WASF2 IL32 BAIAP2 ABI2 ABI1 S100A7A LCN2 S100A9 S100A8 LTF S100A7 UBA6 UBE2Z UBE2L3 UBE2Q2 UBE2H UBE2B UBE2E3 UBE2G1 UBE2A UBE2G2 UBE2W UBE2R2 UBA1 DUSP4 DUSP3 PPP2R5D VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B PROS1 F13A1 PRCP CD177 FGB FGA FGG F2 SERPING1 PRTN3 RPLP0 EEF1A1 EEF2 POLR2E POLR2F POLR2H POLR2K POLR2L PPP2R5E NOS1 PPP2R5B PPP2R5A PPP2R5C FGR STIM1 PECAM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 NOS2 NOS3 MAPK14 P2RX7 P2RX1 PTPN6 IRAK1 PELI3 PELI2 PELI1 KPNB1 MIB2 SMAD3 KIF5C KIF5B KIF5A KIFAP3 KIF20A GATA3 KLC1 KLC4 KLC3 KLC2 KIF3B ABL1 KIF3C KIF18A KIF4B KIF4A HBB KIF11 KIF15 CAPZB H3C8 KIF23 KIF22 RBSN KIF2A IRF1 IRF2 KIF2C KIF2B DOCK2 DOCK1 H3C15 SH2B3 CENPE KIF26A CAPZA1 CAPZA2 MYC CTNNB1 KPNA1 CHRNB4 CLTC CLTA MYLIP NPC2 SAR1B IRAK2 RHOA CDC20 IL10 IL6 MYH9 HEXB GM2A ARSA ASAH1 ALDH3B1 NEU1 ORMDL3 PSAP ARSB CTSA VAPA GLB1 DEGS1 PRKCSH MAGT1 GOLGA7 DDOST CANX B4GALT1 ATP6V1A TCIRG1 ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 ATP6V1F ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 SLCO4C1 ROCK1 MUC13 DSP PTPN13 CKAP4 DSG1 GAA GYG1 FLT3 CASP9 MKRN1 AKT3 ZBP1 NLRP4 DTX4 GRAP2 MAP2K4 PLCG2 MAP2K7 JUN VAV3 SYK FOS LCP2 MAPK9 MAPK8 MAPK10 IRS2 APAF1 CASP1 CASP2 NLRC4 CYFIP2 WIPF1 WIPF2 WIPF3 PRKCD DYNC1LI1 DYNC1LI2 IQGAP1 IQGAP2 HMOX2 JUP ARHGAP9 ARPC1B ARPC1A DYNLL2 LRRC41 FLNA STK10 CFL1 ARPC4 ARPC5 ARPC2 ARPC3 NF2 NCK1 ACTR3 ACTR2 BIRC5 PIK3C3 EVL SOS2 CSK RBBP6 WASF3 BTK PIK3R4 PIK3R3 DSN1 PTK2 FAF2 WASL SH3RF1 RAC2 SPTAN1 RHOG RHOF RHOU WAS DYNC1I1 MYO9B RAB9B ACTG1 ARHGAP45 ELMO2 NCKIPSD DIAPH1 LMNB1 YWHAZ ZAP70 MOSPD2 PTK2B STOM VHL LIMK1 MAPK11 VIM COL1A2 MAP2K1 TNIP2 MAP3K8 YES1 HNRNPF CD4 TREX1 POLR1C POLR1D ACAA1 DNAJC3 IRS1 PIK3CD PIK3CB HGF FLT3LG GAB2 CD19 TRAT1 PIK3AP1 FABP5 HSPA8 FOXO3 ELK1 CREB1 BCL2 AMPD3 APRT PNP RAP1B RAP1A FN1 KRAS RAF1 VCL GUSB HPSE FCGR3B PLAUR BST1 ATF2 AHCYL1 PRKCE TRIB3 MAPKAP1 EGR1 RICTOR NEDD4 FRK KPNA2 FOXO1 THEM4 MYD88 PRR5 PTEN IRAK4 STUB1 LRRFIP1 STAT1 TICAM1 TLR3 ARF1 RALA PITPNA BOLA2B CNN2 CA1 HNRNPDL STAT4 IL12B IL12A IL12RB1 IL12RB2 JAK1 HSPA9 SERPINB2 ANXA2 GSTO1 AIP MSN TYK2 MIF SOD2 SOD1 MTAP VAMP7 IFNG GSTA2 HNRNPA2B1 PDCD4 SNRPA1 LCP1 PPIA MEF2A MEF2C RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 IL1RN IL18RAP IL36A IL36B IL1R1 IL1R2 SIGIRR SQSTM1 IL36RN MAP2K6 GSDMD IL36G IL1F10 IL4 TOLLIP PTPN20 PTPN23 IL18BP RIPK2 IL13 IL18 IRAK3 IL1A IL1B IL1RAPL1 NOD1 NOD2 IL1RL2 ALOX5 MAP3K3 PTPN18 IL37 PTPN12 PTPN14 PTPN9 PTPN7 PTPN4 PTPN5 IL18R1 PTPN2 CALR CSF3R IL6R NANOG PKP1 DSC1 RAP1GAP PTPRC ITGAV MYO10 STX1A SMARCA4 PPP3CB CD36 CAP1 ENAH SH3GL2 TYROBP MAPK12 MAPK13 ELOB ELOC TNF GRB10 CUL2 PI3 TREM2 CEBPD NFASC SOX2 KRT1 SPTBN2 VASP SIAH2 SIAH1 SH3KBP1 SDCBP DNM1 DNM2 DNM3 NCAM1 GPR84 POMC LRR1 CCNF KEAP1 CBLB DCAF1 HERC4 HERC3 RNF115 RNF114 HERC1 TRIM21 FBXO7 RNF111 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 NEDD4L UBE2J2 CAMK2B UBE2J1 RNF213 RNF217 CAMK2D ATG7 HACE1 LNPEP CAMK2A MEX3C UBAC1 FBXL8 FBXL4 DZIP3 FBXL7 RNF220 DET1 LRSAM1 TRIM9 LRRC7 ARIH2 RNF144B GAN CALM1 RNF138 RNF130 CAMK2G HUWE1 KLHL2 WWP1 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM CPNE1 TRIP12 CPNE3 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 DGAT1 RNF19B UBE3A UBE3B FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 FBXO17 CSNK2B UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 PLD4 KCTD7 TRAIP RNF41 PLA2G6 KLHL42 PLD1 UBE2V2 PLD3 CUL7 PLD2 CUL5 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 SOCS3 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F KLHL25 SMURF2 SMURF1 ZBTB16 GLMN KLHL21 SLC44A2 KLHL22 LPCAT1 BTBD6 FBXO32 FBXO30 FBXO31 KLHL20 UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 BLMH UBE2M TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 TRIM69 UNKL TRIM63 DTX3L PJA2 PJA1 TRAF7 THOP1 TRIM50 RNF34 MGRN1 AGPAT2 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 PLA2G2A HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 ACTR1A ASB3 ASB1 PPP2R1A UNC93B1 LY96 CD14 S100A1 TIRAP BTRC PRKACA TLR1 TLR10 CEP290 TLR6 TLR5 TLR4 TLR2 BLK SKP1 HSP90AA1 FBXW11 TUBB RORA DYNLL1 HIF1A UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 ANXA1 FPR1 UBB FPR2 UBC RPS27A DYNC1H1 BCL2L11 TUBB4B STAT5A STAT5B FASLG CSH1 PTPN11 PRL PRLR TNFRSF1A RBX1 GH2 BIRC2 GHR BIRC3 GH1 JAK2 IKBKB PSMD8 PSMD9 ATF1 PSMD6 PGLYRP4 PSMD7 PGLYRP3 PSMD4 PGLYRP2 PSMD5 GMFG PSMD2 SLA2 PSMD3 C3AR1 PSMD1 PGLYRP1 IKBKG CXADR MAP3K7 MCEMP1 CHUK TXNIP PRKCB LTA4H PSMA5 HLA-DRB5 PSMA6 HLA-DRB4 PSMA3 TSLP PSMA4 FUCA1 PSMA1 FUCA2 PSMA2 IL31RA PSME3 EIF2AK2 PSME4 TREML1 PSME1 TREML4 PSME2 TREML2 CARD11 HLA-DRB3 PSMD10 HLA-DRB1 PSMB11 LGMN PSMD12 SIGLEC9 PSMD11 PANX1 PSMD14 OLR1 PSMD13 JAK3 BCL10 HCST PSMA7 PAFAH1B2 RELA RAPGEF3 MALT1 RAPGEF4 PSMB10 GSTP1 PSMA8 PTAFR PSMB6 STX4 PSMB7 STX3 PSMB4 KIR3DL1 PSMB5 KIR3DL2 PSMB2 TRAV8-4 PSMB3 SIGLEC1 PSMB1 YPEL5 PSMF1 SIGLEC8 NFKB1 SIGLEC7 PSMB8 SIGLEC6 PSMB9 CRLF1 NFKBIA SIGLEC5 SEM1 CRLF2 PSMC5 CRCP PSMC6 SLA PSMC3 APEH PSMC4 TOM1 PSMC1 TNFRSF8 PSMC2 TNFRSF4 REL CISH NFKBIE IST1 NFKBIB TBK1 ATP11B ATP11A STING1 CNPY3 STAT6 ACLY JAML IL6ST SLC27A2 ARL8A FTL CD274 REG3A REG3G HSP90B1 TNFRSF17 SHC1 TNFRSF14 TXNDC5 IP6K2 TNFRSF9 PIK3R1 LY86 CBL OSBPL1A NRAS NIT2 SNAP25 PIK3CA CIITA ITGAM PLCG1 KIR3DS1 SOS1 ITGB5 HRAS LEAP2 ITGB2 ITGAL TNFSF13B ALAD ITGAX TRIM68 ITGB7 ACP3 SNAP29 CDH1 PGM1 MBL2 TRIM62 PIANP ITGA4 RNASET2 CAPN1 TNFRSF18 PRSS2 TNFRSF1B MUC5AC TMBIM1 TNFRSF25 BPI TRIM56 ADAM10 BECN1 CANT1 C1S ADAM17 C1R IL2RG TRIM46 TRIM48 ADAM8 RILP TRIM45 TSPAN14 MYO1C PSEN1 IL2RA IL2RB TRIM35 PDCD1 TRIM38 TRIM31 NCSTN TRIM34 TNFRSF6B ICAM2 ICAM3 ELANE ICAM4 ICAM5 ICAM1 CRKL IL27RA C4A LGALS3 MT2A TRIM29 CTSV ANPEP CTSS TNFSF11 TRIM26 LGALS9 MMP25 TRIM22 C6orf120 SLPI CTSL TRIM17 CRISPLD2 CASP3 TRIM14 CTSK CD226 TIMP2 TRIM10 CTSG TMEM63A TIMP1 DHX9 MMTAG2 SYNGR1 CTSD TNFSF18 TNFSF14 CTSB TNFSF15 TNFSF12 MMP1 TNFSF13 RAB27A MMP2 MYO5A MMP3 NBEAL2 MMP8 PPBP MMP9 BST2 CD207 GRB2 CD200 IL21 IGHM IL22 IL20 IL25 IL26 IL24 CD44 IL27 LAMA5 C8B C8A PPP3CA ACTR1B C8G MUC12 FCER1A MUC15 CAMP IL11 FCER1G IL15 IL19 IL16 RAP2C RAP2B IGHD RELB IL31 GCA IL34 OSM CFHR2 CFHR1 CFHR4 CFHR3 SEMG1 CFHR5 ACTR10 INPPL1 SRP14 PLAU ENPP4 RAG2 RAG1 IL4R IRAG2 MUC3A MUC3B PPIE DAPP1 ADGRG3 TRAV19 MGAM VCAM1 MUC16 MUC17 CRTAM MUC19 GGH ADA2 IGF2R IL7R MUC20 MUC21 MS4A3 TNFAIP6 ADAR ADGRE5 ADGRE3 ATP6AP2 TAPBP CAT CHI3L1 MS4A2 IL9R RETN CAND1 MUC5B GALNS TEC PTX3 SUGT1 CDA CNTF FRMPD3 UBE2D2 IGHV3-23 CLEC10A AP1S2 UBE2D1 IGLV AP1S1 AP1S3 IGLV2-8 IGKV1-16 PRSS3 IGKV1-17 ARMC8 IGKV1-12 ATG14 IGHV3-7 CFH IGHV3-9 PRKDC CFI V2-11 IGHV3-30 CFP PLAC8 V3-4 HMOX1 V3-3 HLA-DQA2 V2-17 HLA-DQA1 V3-2 IGHV3-33 NFATC3 NFATC2 V2-15 NFATC1 IGKV1D-39 TCN1 V2-19 GPI IGKV1D-33 CDC34 PYGB GNLY IGKV2D-28 EDARADD IGKV4-1 AHSG IGHV7-81 PRKCQ ZEB1 PLEKHO2 UBE2V1 HLA-DQB2 V1-11 HLA-DQB1 IGKV2D-30 GRN V1-16 TRBV12-3 V1-13 TRBV7-9 IGHV4-59 GSN IGHV1-69 IL10RB RASGRP2 IL10RA RASGRP1 CLCF1 RASGRP4 CSF3 IGLV2-11 MRE11 IGLV1-40 RAB3A IGLV1-47 CSF2 IGLV6-57 CSF1 IGLV2-14 TMEM179B IGLV1-44 RAB3D IGKV3-15 IL5RA IGKV3-11 CLU LYN DEFB109B V2-8 IGHG3 V1-20 RAB44 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGHG2 IGKV1D-16 LAMP1 IGLV7-43 LAMP2 IGKV1D-12 IL13RA2 IGLV1-51 IL13RA1 IGLV2-23 UBE2N MAP2K3 KCMF1 TAB3 ILF2 TAB2 EDAR TAB1 RAB31 IGKV3-20 RAB37 IGHV4-34 IFNAR1 IGHV1-2 RAB5B IGHV1-46 RAB5C IGHV4-39 IGHV CD300LB BTLA IGKV2-29 CD300LD IGKV2-28 RAB6A IGLC3 CD300LF IGLC1 CD300LG IGLC2 AP1M2 V1-9 V5-4 AP1M1 MCL1 V1-7 V5-1 RAB4B TRAPPC1 V1-5 PDPK1 POLR3GL BCL6 V1-3 MAP3K14 IGKV3D-20 V5-6 LAT BCL2L1 TRAF6 IGHE FCAR PSTPIP1 IGLV3-19 AP1G1 IGKV2-30 LBP IGHV2-70 CR2 IGHV2-5 IGLV3-1 CR1 IGHV3-48 PKM DNAJC5 IGLV3-25 CRK IGLV3-27 IGKC CRP IGKV1-39 FGL2 NLRC3 IGLV3-21 IGKV1-33 TTR V4-6 RAB24 IGHV3-53 IL21R V4-2 CPPED1 RAB10 IGLC7 V4-1 POLR3A IGKV5-2 POLR3B IGKV1-5 POLR3C POLR3D IGLC6 POLR3E PRKACG RAB18 PRKACB POLR3F POLR3G POLR3H POLR3K NECTIN2 IFITM3 IFITM1 IFITM2 CALML5 IL23R IFIT5 KIF3A IFIT1 IFIT3 IFIT2 FTH1 TBC1D10C ICOSLG IL15RA HLA-H HLA-B AP1B1 HLA-C HLA-A HLA-F HLA-G HLA-E IL23A TXK STXBP2 TWIST1 TRAV29DV5 CD79B CD79A MLEC VAT1 SH2D1A SH2D1B LIF RAET1E ORM1 ORM2 ITCH SEC61G CREBBP SEC61B PDCD1LG2 HCK TLR9 TLR8 TLR7 C1QB CSTB C1QA CST3 LAIR2 LAIR1 EP300 PTGES2 SVIP CD40LG CAPZA3 IL33 QPCT IL1RL1 SIPA1 TP53 C1QC FCN1 FCN2 FCN3 PVR COTL1 IL11RA LIFR COPB1 ALOX15 CUL3 LPO NLRP3 NLRP1 POU2F1 IDH1 KBTBD7 SELL BRWD1 C3 CFD CGAS GZMM OASL CFB HK3 CASP4 BLNK HGSNAT DCD MYH2 AIM2 OAS1 SUMO1 OAS2 OAS3 LTA IFNA5 LTB IFNA4 DEFB4B OTUD5 COLEC12 COLEC11 APP IFNA7 PDXK IFNA6 COLEC10 CLEC12A HSP90AB1 IFNL2 UBE2D3 IFNA2 MUC1 TNFAIP3 IFNL1 MUC2 UBE2L6 MUC7 HMGB1 IFNA8 GBP2 HERC5 GBP1 IFIH1 IFNL3 CASP8 MUC4 GBP4 TRIM4 CASP10 GBP3 MUC6 NKIRAS1 TMEM30A NKIRAS2 C4BPA DHX58 TRIM25 C4BPB TRBC1 IKBKE GBP6 TOMM70 IFNA13 GBP5 IFNA14 GBP7 IFNA16 RNASE6 RNASE3 DDX58 IFNA17 SCAMP1 RNASE2 TRAF2 ATG12 FLG2 SIKE1 PADI2 IL20RA RNF125 IL20RB IRF3 C2 TRAF3 IL22RA2 IRF7 TAX1BP1 C5 IFNA10 KLRK1 NLRX1 C6 UBA7 CYB5R3 NLRC5 C7 C9 AGER FYB1 TANK AZU1 RNF135 TKFC LYZ RNF216 HRNR IL22RA1 PCBP2 PIGR S100A12 ECSIT RIPK1 EEA1 FADD ATG5 CTLA4 IFNA21 HLA-DPA1 MAP3K1 RIPK3 IFNB1 ARG1 PGAM1 ISG15 TMC6 S100B VAMP2 NFKB2 SERPINB10 CYLD SERPINB12 MAVS SAA1 RNASEL CTF1 PIN1 UBE2K PTGS2 HLA-DMA HLA-DMB CDKN1A RNASE8 RNASE7 CDKN1B FLNB STAT2 ANAPC10 LRG1 ANAPC11 HLA-DPB1 RORC FZR1 HP CDC23 DEFB1 PIM1 KPNA7 CCND1 CDC26 KPNA4 CDC27 KPNA5 HLA-DOA HLA-DOB KPNA3 LAG3 SKP2 TICAM2 ANAPC7 OLFM4 UBE2C TXLNA MAPKAPK3 UBE2E1 MAPKAPK2 FSCN1 CPB2 TNFRSF11B TNFRSF11A UBE2S SOCS2 SOCS6 SOCS5 CDC16 DEFA6 DEFA4 ANAPC4 DEFA5 ANAPC5 DEFA3 ANAPC1 CXCL10 ANAPC2 PTPRB HLA-DRA FCGR3A PPP2CA ATP7A PPP2CB NDUFC2 PPM1B MAPK1 SEC22B SEC23A MAPK3 PTPRZ1 IFI16 CCL5 TIFA CCL4 CCL3 CCL2 FCGR1A AAMP PTPN1 SEC24B SEC24A ERAP2 ERAP1 ATOX1 FCGR2A SEC24D FCGR2B SEC24C TALDO1 VPS35L EIF4A2 DERA EIF4A1 IFI35 IFI30 PGM2 BPIFA1 BPIFA2 RSAD2 IFI27 ALPK1 DEFB103B CD86 CDC42 CD1D CD1C PAK1 LCK CD1B CD1A CD80 ART1 CD28 FYN COMMD9 RAC1 DHX36 SLAMF7 PAK3 SLAMF6 PAK2 VAV1 PAG1 SEC31A PRKN CCR1 DEFB104B XRCC6 VCP XRCC5 SURF4 PRG2 PILRB PRG3 PILRA BPIFB2 BPIFB1 BPIFB4 BPIFB6 CD27 CYSTM1 CD22 DEFB105B SDC1 TNFRSF13B CTSZ CD3G PTPRJ TNFRSF13C CD3E CD3D EDA2R BTNL9 CTSO BTNL8 CTSH BTN2A2 QSOX1 BTN3A1 CD209 CTSF CCR6 BTN2A1 BTN1A1 ARIH1 CTSE BTN3A3 CCR5 BTNL2 CD33 BTN3A2 XDH CTSC PPL CCR2 CD53 DEFB106B DBNL MME TNFRSF12A COMMD3 ANO6 OSMR NCR1 LAT2 NCR2 NCR3 CD47 APOB CD46 CD63 DEFB129 DEFB128 DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB121 DEFB107B CPN2 CPN1 P4HB PGRMC1 CREG1 CD59 CD58 MICA ACTB CD55 MICB NPDC1 CD74 CD70 DEFB136 FBXO4 DEFB135 DEFB134 FBXO6 DEFB133 DEFB132 DEFB108B DEFB108C FBXW4 IL17F FBXW5 CD68 FBXW10 IL17C FBXW7 IL17A FBXW9 CD81 TRAC FBXW2 MPO OSTF1 EPPIN CD96 CD93 ATAD3B MID1 OSCAR DOK3 CD8A MASP1 CCL3L3 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 RASGRP3 CD99 IL2 ISG20 IL3 IL5 FBXL3 IL7 TARM1 FBXL5 IL9 DDX3X EDA DDX41 SIRPB1 SEC61A2 SEC61A1 DYNLT1 IRF4 CCT2 IRF8 IRF5 IRF6 IRF9 DCTN6 TCP1 DCTN5 DCTN1 MVP DCTN4 SAMHD1 DEFA1B CHGA MX2 MX1 PDAP1 S100P CNTFR ABCA13 JUNB NHLRC3 UNC13D BIN2 A1BG MEFV PPP3R1 CRACR2A PRDX4 CCT8 S100A11 KIR2DS1 KIR2DS2 KIR2DS4 KIR2DS5 PA2G4 STAT3 PRDX6 TNFSF6 TNFSF4 TNFSF9 TNFSF8 CD8B CDK13 AP2S1 GSDME SERPINA3 ATP6V1H AP2A1 ITK AP2B1 SERPINA1 AP2A2 MRC2 AP2M1 TRIM8 TRIM6 TRIM5 TRIM2 MRC1 TRIM3 HAVCR2 SERPINB3 VEGFA SERPINB1 IFNGR1 NUP107 NFAM1 NUP188 IFNGR2 SERPINB6 FCER2 CD200R1 CCL11 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.1 Processing of SMDT1 STOML2 MCUB SPG7 MAIP1 PHB2 PARL AFG3L2 SMDT1 PMPCB YME1L1 PMPCA MICU3 MICU2 MICU1 PHB1 MCU DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 80%9675151 Disorders of Developmental Biology NCOR1 TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X CALM1 NCOR2 PRKACA HDAC3 ACTIVATION OF TRKA RECEPTORS%REACTOME%R-HSA-187015.2 Activation of TRKA receptors NTRK1 NTRK2 ADORA2A NGF ADCYAP1 ADCYAP1R1 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 80%9701193 Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function RAD50 RAD51 RAD51B RAD51C DNA2 BLM MRE11 WRN SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.6 Diseases of programmed cell death EZH2 LMNB1 H3C15 SUZ12 JUN TP53 YWHAE CDC25C EED CDKN2A APP C1QBP GOLGA2 DNMT3A CDK5R1 H2AX H3-3B CDC25B H2AB1 PRDX2 H2AC19 PRDX1 H2AC14 CASP8 H2BC12L DNMT3B H2BC21 H2BU1 H2AC8 H2AC6 PRIM2 H2AC7 PRIM1 H2BC17 H2BC12 H2BC13 FOXO3 H2BC14 DNMT1 TRAF2 H2AJ H2BC15 H2BC11 CAPNS1 RBBP4 CAPNS2 RBBP7 CDK5 H2AZ1 H2BC9 CAPN2 H2AZ2 CAPN1 CAST H4C9 H2BC8 POLA1 POLA2 H2BC5 BCL2L11 RIPK1 H2BC3 SOD2 GSDME FADD H2BC1 CDC25A H2AC20 TRADD FASLG H3C8 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 80%399954 Sema3A PAK dependent Axon repulsion HSP90AB1 PLXNA1 PAK1 FES FYN CFL1 RAC1 PAK3 PAK2 PLXNA2 NRP1 PLXNA4 PLXNA3 SEMA3A HSP90AA1 LIMK1 DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 80%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 80%1855167 Synthesis of pyrophosphates in the cytosol IP6K3 NUDT4 IPPK NUDT11 NUDT10 PPIP5K1 ITPK1 PPIP5K2 IP6K1 NUDT3 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.6 Transcriptional Regulation by TP53 GPI YWHAQ YWHAH BLM YWHAZ MRE11 BAX BID WRN AURKB CSNK2A1 CDKN2A CSNK2A2 RPA1 PML CSNK2B MAPK11 PDPK1 BCL6 CCNA2 CCNA1 DNA2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNF34 ATF2 PPP2R5C PIP4K2A PIP4K2B PIP4K2C ELOB ELOC MAPKAP1 AKT3 CREBBP MOV10 PCNA EP300 RICTOR GTF2F1 MBD3 GTF2F2 RFC5 MAPK14 RFC3 GATAD2B RFC4 JUN GATAD2A TP53 RFC2 FOS RPA2 YWHAE RPA3 AGO3 AGO4 PPP2R1A AGO1 AGO2 PRR5 PTEN CHD4 CHD3 PRMT5 YWHAG BRIP1 KAT5 EXO1 RBBP8 NBN MTA2 BARD1 PIDD1 RMI2 APAF1 TNRC6C CRADD RMI1 CASP6 TOP3A CASP1 CASP2 TNRC6A RAD51D NLRC4 TP63 RAD50 TNRC6B TP73 CCNH PRDX2 PRDX1 UBA52 CASP10 TBP CCNK TP53RK MT-CO1 EHMT1 NOC2L GLS AURKA TP53AIP1 HUS1 CCNB1 COX7A2L SCO1 UBB SCO2 DDIT4 MT-CO2 MT-CO3 UBC CDK5 RHNO1 L3MBTL1 CDK7 MEAF6 RPS27A MNAT1 NUAK1 TP53BP2 USP2 ATRIP GTF2H1 PRELID3A BANP GTF2H2 PRELID1 GTF2H3 SURF1 GTF2H4 TPX2 GTF2H5 RAD17 DDB2 SFN CDK12 ATR COX7B ERCC3 ELL SETD9 CENPJ CHM TNFRSF10B ERCC2 COX7C TNFRSF10A CDK1 BBC3 TNFRSF10D TAF7L ING5 ING2 PIP4P1 PIN1 EHMT2 AIFM2 ELOA COX8A CDKN1A BRD1 SGK1 CDKN1B COX5B COX5A PMS2 TAF9B BRD7 TIGAR FAS MLH1 HIPK1 COX6C POU4F2 LRPPRC HIPK2 E2F1 TTC5 PRKAA1 CCNG1 PRKAA2 TCEA1 MAP2K6 DAXX RAD1 CCNT2 YWHAB PRKAG1 CCNT1 PRKAG2 TACO1 HDAC2 PRKAG3 PRDM1 RPTOR COX6A1 STK11 SESN3 TFDP1 SESN2 CCNE2 AKT2 KMT5A TFDP2 BNIP3L MLST8 SUPT16H AKT1 IGFBP3 CCNE1 COX6B1 SLC38A9 MSH2 CDK2 FANCD2 PRKAB2 KAT6A MAPKAPK5 COX19 COX16 TSC2 COX18 PPP2CA TSC1 NDRG1 PRKAB1 PPP2CB SMYD2 PMAIP1 MTOR COX11 COX14 RRAGA BCL2L14 RRAGC ZNF420 FANCI BRPF1 RHEB RRAGB BRPF3 TNFRSF10C RRAGD ELOA2 LAMTOR2 FANCC LAMTOR1 CDK9 LAMTOR4 TP53I3 PHF20 LAMTOR3 JMY CHEK2 LAMTOR5 CDC25C CYCS TAF4B ZNF385A RAD9B PCBP4 RAD9A MDM2 COX20 G6PD MDM4 DYRK2 ATM PPP1R13B COX4I1 TRIAP1 PPP1R13L TOPBP1 GPX2 RABGGTB RABGGTA RRM2B TMEM219 GLS2 TAF9 HDAC1 TAF1L CDK5R1 TP53INP1 RFFL TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 TAF11 SSRP1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 BIRC5 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CHEK1 PLK2 USP7 PPP2R1B BTG2 TNKS1BP1 CNOT6L PRMT1 RBL2 RBL1 PLAGL1 E2F4 E2F7 E2F8 PLK3 GADD45A ARID3A CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT1 CNOT11 CARM1 CNOT2 CNOT3 CNOT8 CNOT9 STEAP3 RBBP4 RBBP7 NPM1 CDK13 PERP MDC1 BRCA1 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 80%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CYCS CASP3 XIAP CASP7 DIABLO CASP9 APAF1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 80%69052 Switching of origins to a post-replicative state ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SKP2 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME4 UBE2S PSME1 CCNE1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 UBA52 GMNN CUL1 ORC5 ORC4 ORC6 ORC1 UBB ORC3 ORC2 CDT1 CDC6 UBC RPS27A MCM7 MCM8 RBX1 MCM3 UBE2D1 MCM4 ANAPC15 MCM5 MCM6 ANAPC16 MCM2 ANAPC10 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%R-HSA-3304347.1 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.7 Activation of NMDA receptors and postsynaptic events RPS6KA2 RPS6KA1 ADCY1 ADCY8 GRIA3 GRIA4 CAMK2B PRKAA1 GRIA1 PRKAA2 GRIA2 CAMK2D ACTN2 PRKAG1 SRC PRKAG2 CAMK2A PRKAG3 NRG1 GRIN2C GRIN2B GRIN1 NRGN PRKX CAMKK1 GRIN2D CAMKK2 GRIN2A DLG1 DLG2 DLG3 LRRC7 PRKAB2 DLG4 NEFL CALM1 CAMK2G PRKAB1 KPNA2 MAPK1 MAPK3 NBEA PRKACA LIN7B CAMK4 PDPK1 RAC1 GIT1 NRAS RASGRF2 HRAS CREB1 PRKAR2B RASGRF1 KIF17 PRKACG PRKACB CASK LIN7A LIN7C PPM1E RPS6KA6 PPM1F GRIN3B PRKAR1B APBA1 PRKAR1A CAMK1 PRKAR2A RPS6KA3 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.1 Regulation of PTEN stability and activity TRIM27 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 MKRN1 AKT3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 XIAP AKT2 PSME3 PSME4 WWP2 PSME1 AKT1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 RNF146 PSMD14 NEDD4 PSMD13 FRK PSMA7 TNKS PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PTEN PSMB8 PSMB9 CSNK2A1 SEM1 PSMC5 CSNK2A2 PSMC6 USP13 PSMC3 PSMC4 PSMC1 TNKS2 PSMC2 CSNK2B STUB1 OTUD3 PREX2 UBA52 UBB UBC RPS27A ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.1 Acetylcholine inhibits contraction of outer hair cells CHRNA9 CHRNA10 KCNN2 KCNMB1 KCNMA1 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME%R-HSA-3560801.1 Defective B3GAT3 causes JDSSDHD GPC2 GPC5 CSPG4 DCN GPC4 AGRN GPC6 HSPG2 BCAN SDC4 NCAN SDC2 SDC3 B3GAT3 BGN VCAN GPC1 GPC3 CSPG5 SDC1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 80%212676 Dopamine Neurotransmitter Release Cycle RAB3A CASK LIN7A LIN7C APBA1 UNC13B SYT1 SYN3 CPLX1 SNAP25 SYN2 STX1A SYN1 RIMS1 PPFIA1 VAMP2 PPFIA4 TSPOAP1 PPFIA3 PPFIA2 SLC18A2 LIN7B ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 80%1482788 Acyl chain remodelling of PC PLA2G3 PLA2G5 PLA2G2F PLA2G6 PLA2G2D PLA2G2E PNPLA8 PLA2G2A MBOAT2 TMEM86B LPCAT4 LPCAT3 LPCAT2 LPCAT1 PLA2G4F PLB1 PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLA2G10 PLA2G1B PLBD1 PLA2R1 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.2 Sialic acid metabolism ST8SIA6 ST3GAL6 NANS ST6GAL2 ST6GALNAC2 ST8SIA1 ST8SIA3 ST6GALNAC5 ST6GALNAC6 GNE ST3GAL4 ST3GAL1 SLC35A1 ST3GAL2 ST3GAL3 ST8SIA4 ST6GAL1 NEU2 NEU3 ST8SIA2 NEU1 ST6GALNAC3 ST6GALNAC4 CTSA ST6GALNAC1 CMAS NPL NANP NEU4 SLC17A5 GLB1 ST8SIA5 ST3GAL5 FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-HSA-5654700.3 FRS-mediated FGFR2 signaling FGF22 FGF10 FGF16 FGF7 FGF18 NRAS SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 80%1480926 O2 CO2 exchange in erythrocytes RHAG SLC4A1 AQP1 CYB5R2 CYB5R1 CA1 CYB5R4 CA2 CA4 HBB HBA2 CYB5RL CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 80%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RPS6KA2 RPS6KA1 PDPK1 CAMK2B CAMK2D ACTN2 CAMK2A NRAS GRIN2B RASGRF2 GRIN1 HRAS GRIN2D DLG1 DLG2 CREB1 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G RASGRF1 MAPK1 RPS6KA6 MAPK3 RPS6KA3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 80%3371556 Cellular response to heat stress NUP62 NUP214 NDC1 HSPA5 SEC13 NUP210 CAMK2B HSPA6 HSPA1B HSPA1A NUP133 CREBBP CAMK2D CAMK2A MAPKAPK2 RPTOR EEF1A1 NUP93 HSPB8 HIKESHI CCAR2 MLST8 EP300 HSBP1 NUP50 DNAJC2 NUP54 DNAJC7 FKBP4 NUP205 CRYAB POM121 RPS19BP1 HSPA4L AAAS HSPA14 HSPA13 NUP160 CAMK2G RPA2 HDAC6 DNAJB1 YWHAE BAG5 HSPH1 POM121C MTOR RPA3 DNAJB6 NUP42 MAPK1 BAG2 NUP85 BAG3 MAPK3 HSF1 TPR BAG1 NUP88 HSPA1L NUP43 HSPA4 AKT1S1 RAE1 ST13 RANBP2 HSPA7 PTGES3 HSPA2 HSPA8 HSPA12A HSPA12B NUP155 RPA1 HSP90AA1 NUP153 ATM NUP35 NUP37 HSP90AB1 BAG4 SIRT1 VCP HSPA9 ATR GSK3B NUP107 NUP188 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 80%9664323 FCGR3A-mediated IL10 synthesis IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 CALM1 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 FCGR1A IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 FCGR2A IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 PLCG1 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB CD3G YES1 ADCY9 PRKAR1B PRKAR1A IL10 PRKAR2A AHCYL1 FGR ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ITPR1 ADCY5 ITPR2 ITPR3 HCK PRKX PLCG2 SYK PRKACA CREB1 PRKAR2B IGHV3-23 IGLV IGLV2-8 IGKV1-16 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 80%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.1 Estrogen-dependent gene expression CCND1 CCNT1 SMC1A H3C15 MYC RAD21 CDK9 RUNX1 CBFB STAG1 STAG2 HDAC1 KCTD6 H3-3B POLR2A POLR2B MED1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L ATF2 CITED1 YY1 CREBBP MOV10 TGFA ESR1 KAT2B GPAM EP300 GTF2F1 GTF2F2 FKBP4 CTSD JUN FOS CXCL12 KPNA2 AGO3 NCOA2 AGO4 AGO1 POU2F1 AGO2 PTGES3 FOXA1 TLE3 PGR DDX5 JUND KDM1A KAT5 GREB1 SP1 HSP90AA1 CHD1 AXIN1 NR5A2 TFF3 TNRC6C MYB TFF1 GTF2A1 KANK1 GTF2A2 TNRC6A PRMT1 CXXC5 KDM4B TNRC6B HSP90AB1 USF2 USF1 ZNF217 H2AX FOSB H2AB1 EBAG9 H2AC19 H2AC14 GATA3 H2BC12L H2BC21 TBP H2BU1 H2AC8 NRIP1 CARM1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 BCL2 H2BC11 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 NCOA1 H2BC3 H2BC1 NCOA3 H2AC20 H3C8 SMC3 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.3 Cargo trafficking to the periciliary membrane RAB8A CCT3 CCT2 ARF4 PKD2 PKD1 CNGA2 TCP1 BBS9 CNGA4 BBS7 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 RP2 BBS12 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 CNGB1 EXOC1 UNC119B CCT8 ARL6 ARL3 CCT5 ASAP1 CCT4 MCHR1 RHO NPHP3 SMO RAB11FIP3 BBS2 BBS1 RAB3IP GBF1 BBIP1 RAB11A TTC8 ARL13B INPP5E PDE6D METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%425410 Metal ion SLC transporters SLC30A5 SLC11A2 SLC39A10 SLC30A1 SLC39A14 SLC40A1 CP SLC41A2 SLC41A1 SLC30A10 HEPH SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC31A1 SLC11A1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 80%2173789 TGF-beta receptor signaling activates SMADs PPP1R15A USP15 LTBP4 NEDD4L NEDD8 LTBP2 LTBP3 LTBP1 ITGB8 UBA52 CBL PMEPA1 ITGB6 TGFB2 TGFB3 UCHL5 SMAD4 SMAD7 BAMBI ITGB5 ITGA8 STRAP SMURF2 UBB SMURF1 UBC XPO1 PPP1CA RPS27A FKBP1A ITGAV PPP1CB PPP1CC UBE2M ITGB3 SMAD2 TGFB1 FURIN SMAD3 TGFBR1 TGFBR2 ITGB1 MTMR4 STUB1 TRAF3 DEFICIENCY - HSE%REACTOME%R-HSA-5602571.2 TRAF3 deficiency - HSE TICAM1 TLR3 TRAF3 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 80%3359467 Defective MTRR causes HMAE MTRR MTR PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.6 Phosphate bond hydrolysis by NUDT proteins NUDT16 NUDT5 NUDT15 ADPRM BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 80%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.2 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 80%6793080 rRNA modification in the mitochondrion MRM2 MRM3 NSUN4 MTERF4 TFB1M MRM1 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358752.2 CTNNB1 T41 mutants aren't phosphorylated PPP2CA PPP2CB AMER1 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 80%453274 Mitotic G2-G2 M phases PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 E2F3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 FBXL7 PSME1 PSME2 PSMD10 CDK2 PSMB11 CENPF WEE1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB PPP2R2A PSMB10 PPME1 PSMA8 PHLDA1 PSMB6 GTSE1 PSMB7 FKBPL PSMB4 TUBGCP2 PSMB5 HMMR PSMB2 PKMYT1 PSMB3 TUBGCP5 PSMB1 PSMF1 TUBGCP6 TUBGCP3 TUBGCP4 PSMB8 LIN54 PSMB9 CDC25C FOXM1 SEM1 MYBL2 LIN52 PSMC5 TUBG2 PSMC6 MZT2B PSMC3 MZT2A PSMC4 NME7 PSMC1 LIN37 PSMC2 LIN9 LCMT1 CDK11A PPP2R3B CDK11B MZT1 CCNA2 CCNA1 CDC25A FBXL18 EP300 TP53 CEP57 YWHAE XPO1 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG PPP2R1B CDK5RAP2 SKP1 OFD1 HSP90AA1 CEP135 PPP1R12A BORA FBXW11 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HSP90AB1 HAUS5 CCNH CSNK1E TUBG1 CDC25B DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 UBA52 SFI1 AJUBA OPTN SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 RBBP4 UBC CEP72 CEP192 CDK7 MNAT1 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 TPX2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 RBX1 CDKN1A SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 80%5654719 SHC-mediated cascade:FGFR4 FGF19 FGFR4 FGF16 FGF18 KLB NRAS SOS1 HRAS FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 80%350864 Regulation of thyroid hormone activity DIO3 DIO1 DIO2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 80%112043 PLC beta mediated events PRKCG ADCY3 PRKCA ADCY2 ADCY1 ADCY8 PDE1C PDE1B ADCY7 PDE1A ADCY6 ITPR1 ADCY5 ITPR2 CAMK2B ITPR3 CAMK2D CAMK2A PRKX CAMKK1 CAMKK2 CALM1 CAMK2G KPNA2 MAPK1 GRK2 NBEA PRKACA GNAQ PLCB3 PLCB4 PLCB1 PLCB2 CAMK4 GNA14 PRKCD GNA15 CREB1 GNA11 PRKAR2B PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PLA2G4A PRKAR2A AHCYL1 ADCY4 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.1 Defective CHST3 causes SEDCJD CSPG4 DCN CHST3 NCAN BGN VCAN BCAN CSPG5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 80%176409 APC C:Cdc20 mediated degradation of mitotic proteins ANAPC11 PSMD8 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NEK2 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTTG1 CCNA2 CCNA1 UBA52 CCNB1 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 CDK1 UBE2D1 ANAPC15 ANAPC16 ANAPC10 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME%R-HSA-5632968.1 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 80%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB HADHA ACADL POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.2 Polo-like kinase mediated events PKMYT1 PLK1 CDC25A LIN54 CDC25C FOXM1 MYBL2 LIN52 EP300 LIN37 LIN9 CCNB2 CCNB1 WEE1 CENPF RBBP4 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.4 Pre-NOTCH Transcription and Translation CCND1 E2F1 E2F3 CREBBP MOV10 NOTCH1 MAML2 MAML1 H3C15 RBPJ TFDP1 KAT2B KAT2A TFDP2 SNW1 EP300 MAML3 MAMLD1 JUN TP53 AGO3 AGO4 AGO1 AGO2 RUNX1 TNRC6C TNRC6A TNRC6B H2AX H3-3B H2AB1 H2AC19 H2AC14 SIRT6 H2BC12L ELF3 NOTCH2 H2BC21 NOTCH3 NOTCH4 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 PRKCI H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H3C8 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME%R-HSA-418890.1 Role of second messengers in netrin-1 signaling NTN1 PLCG1 TRPC7 TRPC5 PITPNA TRPC6 TRPC3 TRPC4 TRPC1 DCC PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 80%3214841 PKMTs methylate histone lysines SUV39H1 KMT2E KMT2D EZH2 SUV39H2 MECOM SETD2 KMT2C PRDM9 H3C15 SETD3 SETD6 DOT1L KMT5A KMT2B EHMT1 SETD7 DPY30 RBBP5 NSD3 NSD1 SUZ12 NSD2 PRDM16 KMT5B SMYD3 RBBP4 ATF7IP RBBP7 SETDB1 KMT5C RELA SMYD2 SETD1B SETDB2 SETD1A ASH1L AEBP2 H4C9 NFKB1 EED NFKB2 KMT2A EHMT2 H3C8 WDR5 ASH2L ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.3 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA RPS3A EIF4EBP1 EIF4E RPS4Y2 EIF4B RPS6 RPS27L RPS4Y1 RPS15A RPS3 RPS2 RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPS24 RPS23 RPS27A EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G RPS4X EIF3H RPS15 EIF3E EIF3F RPS14 EIF3C RPS17 PABPC1 EIF3D RPS16 EIF3A RPS19 EIF3B RPS18 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 80%350562 Regulation of ornithine decarboxylase (ODC) PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ODC1 OAZ1 OAZ2 OAZ3 NQO1 AZIN1 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 80%162909 Host Interactions of HIV factors PSMD8 PSMD9 PSMD6 PSMD7 NUP62 PSMD4 NUP214 PSMD5 NDC1 PSMD2 PSMD3 SEC13 PSMD1 NUP210 NUP133 DOCK2 CCNT1 PSMA5 PSMA6 PSMA3 PSMA4 NUP93 PSMA1 PSMA2 PSME3 PSME4 PSME1 NUP50 PSME2 NUP54 PSMD10 NUP205 POM121 PSMB11 PSMD12 PSMD11 PSMD14 AAAS PSMD13 NUP160 PSMA7 POM121C SLC25A5 PSMB10 NUP42 NUP85 PSMA8 PSMB6 PSMB7 TPR SLC25A4 PSMB4 NUP88 PSMB5 SLC25A6 PSMB2 NUP43 PSMB3 RAE1 PSMB1 RANBP2 PSMF1 CDK9 KPNA1 PSMB8 PSMB9 NUP155 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 NUP153 PSMC1 PSMC2 NUP35 B2M NUP37 AP1M2 AP1M1 LCK CD28 FYN RAC1 CUL5 PAK2 AP1G1 RANGAP1 AP1B1 HLA-A ELMO1 BANF1 HMGA1 PSIP1 PACS1 ELOB RANBP1 ELOC HCK XPO1 RCC1 RAN KPNB1 CD4 BTRC SKP1 UBA52 ARF1 UBB UBC RPS27A NPM1 CD8B AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 PPIA NUP107 NUP188 RBX1 AP1S2 AP1S1 AP1S3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-HSA-1234176.2 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha PSMD8 PSMD9 ELOB LIMD1 PSMD6 PSMD7 ELOC EGLN1 PSMD4 EGLN3 PSMD5 EGLN2 PSMD2 WTIP PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CUL2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 VHL SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2D3 HIF1A UBA52 AJUBA EPAS1 UBB UBC RPS27A UBE2D2 RBX1 UBE2D1 HIF3A KETONE BODY METABOLISM%REACTOME%R-HSA-74182.3 Ketone body metabolism AACS ACAT1 HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.2 Signaling by TGF-beta Receptor Complex in Cancer SMAD2 SMAD4 TGFB1 FKBP1A SMAD3 TGFBR1 TGFBR2 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.1 Defective NTHL1 substrate processing NTHL1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 80%380320 Recruitment of NuMA to mitotic centrosomes NUMA1 CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A TUBGCP2 PPP2R1A CNTRL CEP250 TUBGCP5 NEK2 TUBGCP6 TUBGCP3 PRKACA TUBGCP4 NINL CEP290 YWHAG CDK5RAP2 TUBG2 MZT2B OFD1 MZT2A HSP90AA1 NME7 CEP135 TUBB CEP131 HAUS4 MZT1 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 80%1855183 Synthesis of IP2, IP, and Ins in the cytosol MIOX ISYNA1 INPP1 OCRL MTMR9 MTMR7 INPP4A INPP5B INPP5A INPP4B IMPA1 SYNJ1 IMPA2 INPP5J SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.2 Synthesis of IPs in the nucleus IPPK IP6K2 IP6K1 IPMK ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 80%9660821 ADORA2B mediated anti-inflammatory cytokines production AVP PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A ADRB1 IL6 ADRB2 PRKAR2A HTR4 TAAR3P HTR6 GNAS HTR7 HRH2 PTGIR DRD1 DRD5 TAAR8 ADCY4 TAAR9 ADCY3 TAAR6 ADCY2 ADCY1 ADCY8 TAAR5 ADCY7 ADCY6 TAAR2 ADCY5 VIPR1 VIPR2 TAAR1 SCT RXFP1 RXFP2 GPR176 ADRB3 CYSLTR2 GNAT3 PTGDR LHCGR PRKX ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB GPR83 GPR84 CRHR1 CRHR2 GHRHR MC2R CALCR CGA IAPP GNG10 GPR15 MC1R RLN2 RLN3 GNG12 GPR27 PRKACA GNG11 GLP1R GNG13 GPR25 GPR20 GNB2 ADM PTH1R GNB1 MC4R GNB4 GNB3 INSL3 TSHB GPR39 GNB5 GPR32 FSHB GLP2R GNGT1 AVPR2 GPBAR1 GNGT2 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 GNG3 P2RY11 SCTR CREB1 GNG2 GCG GNG5 TSHR GNG4 POMC GHRH PRKAR2B GNG7 ADM2 GNG8 MC5R VIP RAMP1 GPHB5 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 80%9648025 EML4 and NUDC in mitotic spindle formation INCENP ZW10 KIF2A SEC13 NUP133 KIF2C KIF2B DSN1 RCC2 ZWINT CENPE AHCTF1 CENPF TAOK1 NUP160 EML4 PPP2CA XPO1 PPP2CB NEK9 NEK6 NEK7 NUP85 PPP1CC NDEL1 PPP2R1A NUP43 RANBP2 AURKB PPP2R5D BUB1 PPP2R1B CLASP2 CLIP1 RPS27 MAD1L1 NUP37 MIS12 DYNLL1 CKAP5 DYNC1I1 NDC80 MAPRE1 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L SPDL1 ZWILCH DYNC1LI1 DYNC1LI2 ITGB3BP CENPA KIF18A CENPC KNTC1 RANGAP1 CDCA8 CENPT BIRC5 CENPU SGO1 CLASP1 BUB1B CDC20 SGO2 SKA1 SKA2 BUB3 DYNC1H1 MAD2L1 NDE1 NSL1 PLK1 PMF1 CENPH CENPI CENPK PPP2R5E CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 PPP2R5B NUDC PPP2R5A PPP2R5C DYNLL2 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME DATABASE ID RELEASE 80%5678420 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 80%1169408 ISG15 antiviral mechanism NUP62 KPNA7 NUP214 KPNA4 NDC1 KPNA5 SEC13 NUP210 KPNA3 NUP133 UBE2E1 NUP93 EIF2AK2 NUP50 NUP54 NUP205 EIF4E USP41 POM121 USP18 AAAS NEDD4 NUP160 KPNA2 PPM1B POM121C NUP42 NUP85 MAPK3 TPR NUP88 NUP43 KPNB1 RAE1 RANBP2 EIF4G3 EIF4G2 KPNA1 EIF4E3 NUP155 UBE2N EIF4G1 EIF4E2 NUP153 EIF4A2 EIF4A1 NUP35 NUP37 UBE2L6 HERC5 STAT1 UBA52 TRIM25 MX2 MX1 PLCG1 DDX58 UBB IRF3 UBC JAK1 UBA7 RPS27A EIF4A3 IFIT1 ARIH1 ISG15 PIN1 NUP107 NUP188 FLNB MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 80%2465910 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB CDK1 PPP2R1B PPP2R2D ENSA MASTL CCNB1 PPP2R1A ARPP19 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.1 Defective ACY1 causes encephalopathy ACY1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 80%429914 Deadenylation-dependent mRNA decay EIF4E EIF4B HBS1L TUT7 TUT4 EDC3 EDC4 TTC37 DIS3 EIF4G1 PATL1 NT5C3B XRN1 DCP2 DDX6 PARN WDR61 SKIV2L EIF4A2 EXOSC7 EIF4A1 EXOSC6 EXOSC5 EXOSC4 TNKS1BP1 EXOSC9 CNOT6L EXOSC8 EXOSC3 DCPS EXOSC2 EXOSC1 PAIP1 LSM1 LSM5 LSM4 LSM3 LSM2 CNOT10 PAN2 CNOT4 LSM7 CNOT6 PAN3 LSM6 CNOT7 DCP1A CNOT1 DCP1B CNOT11 CNOT2 CNOT3 CNOT8 CNOT9 EIF4A3 PABPC1 REGULATED NECROSIS%REACTOME%R-HSA-5218859.4 Regulated Necrosis ELANE CHMP4A CHMP6 FAS CHMP7 IRF1 IRF2 GSDMD CASP3 FLOT1 XIAP IL18 IL1A IL1B TP53 BAX PELI1 CYCS CASP4 HSP90AA1 CASP1 FLOT2 STUB1 TP63 HMGB1 CASP8 UBA52 CASP5 PDCD6IP CDC37 BAK1 MLKL GZMB OGT TRAF2 UBB SDCBP UBC TNFSF10 RPS27A RIPK1 GSDME FADD RIPK3 TNFRSF10B TNFRSF10A TRADD FASLG CHMP2B CHMP4C BIRC2 BIRC3 CHMP2A CHMP4B CHMP3 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 80%211994 Sterols are 12-hydroxylated by CYP8B1 PTGIS CYP8B1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 80%168164 Toll Like Receptor 3 (TLR3) Cascade IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 MAPK3 PPP2R1A DUSP4 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N MAPK7 TAB3 PPP2R1B TAB2 SKP1 TAB1 FBXW11 NFKBIB TBK1 MAPK11 APP UBE2D3 HMGB1 TRAF6 CASP8 UBA52 NKIRAS1 NKIRAS2 IKBKE TICAM1 TLR3 CUL1 ELK1 CREB1 UBB IRF3 TRAF3 MAP2K1 IRF7 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER TANK S100A12 RIPK1 FADD RIPK3 S100B NFKB2 SAA1 UBE2D2 ATF2 UBE2D1 MEF2A BIRC2 MEF2C BIRC3 RPS6KA3 RPS6KA5 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.3 Beta-oxidation of very long chain fatty acids ACOT8 EHHADH ACOT6 DECR2 ACOT4 HSD17B4 ACAA1 ABCD1 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.3 Signaling by PDGFR in disease STAT3 PIK3CB PIK3R2 PDGFRA STAT1 PIK3R1 NRAS PIK3CA KDR SOS1 STRN HRAS BIN2 ETV6 GOLGA4 KANK1 WDR48 FIP1L1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 80%174411 Polymerase switching on the C-strand of the telomere CHTF18 TINF2 TERF1 TERF2 POT1 TERF2IP PRIM2 PCNA POLD3 PRIM1 POLD4 CHTF8 POLD1 POLD2 RFC5 RFC3 RFC4 RFC1 RFC2 CTC1 STN1 ACD POLA1 POLA2 TEN1 DSCC1 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.3 Synthesis of PI PITPNM1 PITPNM3 CDIPT PITPNM2 CDS1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 80%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol AKR1D1 AKR1C3 SLC27A2 NR1H4 AKR1C2 AKR1C4 ACOT8 CYP7B1 ABCB11 NCOA2 BAAT CYP7A1 CYP27A1 AMACR NCOA1 HSD17B4 ACOX2 SLC27A5 PTGIS CYP8B1 RXRA HSD3B7 AKR1C1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 80%6802949 Signaling by RAS mutants CNKSR1 FGB KRAS FGA TLN1 VWF RAF1 VCL CAMK2B FGG CAMK2D YWHAB SRC CAMK2A NRAS MAP3K11 HRAS CALM1 CAMK2G MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 PHB1 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 80%879518 Transport of organic anions SLCO1B3 AVP SLC16A2 SLCO1C1 SLCO4A1 SLCO2A1 SLCO1B1 SLCO1A2 SLCO4C1 SLCO2B1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.3 Potential therapeutics for SARS FXYD1 FXYD7 FXYD6 NFE2L2 IL1R1 TLR9 HDAC2 TLR7 ZBP1 MBD3 FKBP4 GATAD2B GATAD2A S1PR1 JAK3 FKBP1A CUL3 PTGES3 ACE2 IL6R CHD4 CHD3 FURIN ITGB1 KDM1A HSP90AA1 MTA1 IFNAR1 MTA2 IMPDH1 ROCK1 MTA3 IMPDH2 TBK1 TUBB REST NR3C1 HSP90AB1 HDAC1 ARID4B PHF21A SAP30 SAP30L RBBP4 SAP18 SUDS3 RBBP7 JAK1 ITGA4 RCOR1 TYK2 ROCK2 AP2S1 RIPK1 ARID4A AP2A1 COMT AP2B1 AP2A2 CYSLTR1 FNTA AP2M1 FNTB KEAP1 SIGMAR1 ATP1B3 ATP1B2 ATP1B1 BRMS1 ATP1A4 HMG20B ATP1A3 IFNGR1 ATP1A2 ATP1A1 PDCD1 IFNGR2 RBX1 BRD4 CRBN FXYD4 STAT2 FXYD3 JAK2 FXYD2 MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 80%5602680 MyD88 deficiency (TLR5) TLR5 MYD88 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 80%9675108 Nervous system development TLN1 SRC GRIN2B GRIN1 DLG1 DLG3 DLG4 CSNK2A1 CSNK2A2 ROCK1 CSNK2B EIF4A3 CASC3 MAGOH NCBP1 NCBP2 RBM8A PIP5K1C UPF3B MAGOHB RNPS1 VAV3 MAPK8 IRS2 PRKACA TRPC7 HSP90AA1 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 ITSN1 UBA52 DOK2 FRS2 PITPNA MYL6 UBB MYL9 NGEF UBC RPS27A CLASP1 MSN ARPC1B ARPC1A PTPN11 RBX1 RPS6KA3 RPS6KA5 RPS6KA2 PSMD8 RPS6KA1 PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 FARP2 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 RPS6 PSMD13 PSMA7 PLXND1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CFL1 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 EIF4G1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 ITGB1 PSMC1 PSMC2 TRIO DPYSL4 DPYSL5 DPYSL2 DPYSL3 ARHGAP39 PLXNA1 SRGAP3 ARHGAP35 UNC5A SRGAP1 UNC5B ARPC4 UNC5C ARPC5 UNC5D ISL1 SHC1 ARPC2 ARPC3 GAB1 PIK3R1 AGAP2 PLXNB1 EGFR NRAS GIT1 PIK3CA PLCG1 L1CAM SOS1 HRAS NCK2 NCK1 ACTR3 VAV2 ACTR2 TIAM1 EPHA2 UPF2 LYPLA2 EVL PIK3R2 SOS2 ROCK2 ADAM10 ABL2 DSCAML1 SRGAP2 ZSWIM8 PSEN1 PAK4 NCSTN NAB1 NAB2 MSI1 COL9A1 COL9A3 PFN1 COL9A2 MAG PFN2 GRB7 LAMC1 UTRN PIK3R3 KALRN SHC3 MYL12B RAP1GAP SPTBN1 CLTCL1 MBP PTK2 WASL MMP2 PTPRC CXCL12 PTPRA MMP9 CNTNAP1 ITGAV NEO1 SPTAN1 ADGRV1 SPTB ETF1 ITGA5 RHOC ITGA9 RHOB NTN4 NTN1 MAPK7 MYO10 NELL2 EPHB6 ARHGEF7 EPHB2 EPHB1 LAMB1 EPHB4 SCN1B SCN1A EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 PAK6 ANK2 PAK5 ANK3 SHTN1 KCNQ2 MYO9B KCNQ3 EPHA1 EPHA3 EPHA10 GSPT2 GSPT1 RRAS ST8SIA4 SCN3B ACTG1 SCN3A WWTR1 EGR2 ST8SIA2 RPL4 SMARCA4 RPL5 ARTN RPL30 CD24 RPL3 SCN2A RPL32 SCN2B RPL31 NRP2 RPL34 RPLP1 PPP3CB RPL10L RPLP0 RPL10A CAP1 ARHGEF28 RPL8 RPL6 RPL7 RGMB SREBF2 RPS4X RPS15 RGMA RPL7A RPS14 ENAH RPS17 PABPC1 RPS16 YAP1 MYH14 RPS19 RELN MYH11 RPL18A RPL36AL CAP2 RPS18 CD72 MYH10 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPS10 RPL39 MPZ RPS13 SCN9A RPS12 NRTN RPS9 RPL21 SH3GL2 RPS7 RPS8 RPS5 RPL23 POU3F1 RPL22 POU3F2 RPL13A DOK1 RPSA TYROBP DOK4 RND1 RPS3A RPL9P9 DOK5 DOK6 SCN8A PRKCQ RPL37A CACNA1D RPL24 CACNA1C ARHGEF11 RPL27 CACNA1H RPL26 CACNA1G ARHGEF12 RPL29 SPTA1 RPL28 CACNA1I RPS4Y2 ADGRG6 RPL10 CACNA1S RPL12 RPL11 RPL36A PRNP RPS27L RPS4Y1 RPS15A RPL14 CNTN1 RPS3 CNTN2 RPL13 LYN RPS2 RPL15 LDB1 RPL18 RPL17 RPL19 RPL39L SCN5A RPL41 RPL35A RPL23A RPL3L SCN4A RPS26 SCN4B RPS25 SHANK3 RPS28 CLASP2 RPS27 RPS29 LAMA2 RPL27A LAMA1 LIMK2 RPL22L1 CRMP1 LIMK1 RPS20 HMGCR FAU RPS21 SLIT1 MAPK11 RPL26L1 RPS24 RPS23 SCN7A SLIT3 SLIT2 PDLIM7 COL4A2 MAPK12 COL4A1 MAPK13 COL6A2 COL4A4 ALCAM SCN11A COL6A1 HOXA2 COL4A3 COL6A3 COL4A5 COL6A6 COL6A5 SOX10 MAP2K1 PRKACG PRKACB YES1 SCN10A PRKAR2A GSK3B RDX UPF3A RET CLTB NUMB ELOB ELOC TEAD1 SEMA5A MAPK14 GRB10 FLRT3 PLXNC1 SEMA6A SEMA6D CACNB1 RASA1 CACNB2 CACNB3 CACNB4 SEMA7A CUL2 PLXNA2 PLXNA4 PLXNA3 DAB1 LHX3 LHX2 PLXNB3 LHX4 LHX9 TREM2 HSP90AB1 SEMA3A SEMA3E ABL1 ABLIM1 ABLIM2 ABLIM3 SEMA4A SEMA4D CYP51A1 CDK5 NFASC KIF4B KIF4A RPS6KA4 RPS6KA6 DAG1 EZR SPTBN4 SPTBN5 MYL12A SPTBN2 VASP SIAH2 SIAH1 DOCK1 HDAC2 ROBO2 SH3KBP1 ROBO1 PRX MAPK1 GFRA1 MAPK3 GFRA3 GFRA2 GFRA4 CXCR4 AKAP5 DRP2 SCD5 RANBP9 CDC42 CDK5R1 CLTC PAK1 NRCAM CLTA FYN VLDLR RAC1 PAK3 PAK2 DSCAM NCAN SDC2 EFNA5 EFNA4 EFNB2 GPC1 SDCBP EFNB1 EFNB3 PSPN EFNA1 EFNA3 EFNA2 AGRN GDNF RHOA FES USP33 HJV DCC MYH9 DNM1 DNM2 DNM3 GAP43 DCX NCAM1 PIK3CD PIK3CB PMP22 GAB2 MET ACTB HSPA8 NRP1 CHL1 CNTN6 ITGA2 ITGA10 ITGA1 ANK1 CREB1 ERBB2 APH1A PSENEN APH1B AP2S1 PSEN2 AP2A1 AP2B1 AP2A2 AP2M1 ITGB3 ITGA2B MAP2K2 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.2 Signaling by NOTCH3 WWC1 YBX1 HEY1 HEY2 HES5 DLGAP5 STAT1 PTCRA EGF CREBBP HEYL NOTCH3 NOTCH1 TACC3 UBA52 MAML2 EGFR MAML1 RBPJ KAT2B PBX1 KAT2A WWP2 SNW1 EP300 HES1 MAML3 MAMLD1 UBB UBC RPS27A PLXND1 APH1A FABP7 PSENEN APH1B PSEN2 JAG2 ADAM10 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 PSEN1 JAG1 NCSTN LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.1 LXRs regulate gene expression to control bile acid homeostasis NCOR1 RXRA FABP6 NR1H2 NR1H3 NCOA1 RXRB NCOR2 UGT1A3 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.1 Sensory processing of sound by outer hair cells of the cochlea TWF1 KCNMB1 CLIC5 RIPOR2 CIB2 PJVK ESPN SPTBN1 EPS8 PLS1 TPRN TMC1 MYO7A TMC2 MYO3B GSN MYO3A KCNQ4 FSCN2 TWF2 PCDH15 USH1C ESPNL EPB41L1 EPB41L3 OTOG SPTAN1 CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 CASK MSN CHRNA9 CHRNA10 KCNN2 MYH9 EZR RDX MYO1C KCNMA1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 80%2161517 Abacavir transmembrane transport SLC22A3 ABCB1 ABCG2 SLC22A2 SLC22A1 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 80%9018683 Biosynthesis of DPA-derived SPMs ALOX15 ALOX12 PTGS2 ALOX5 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.1 PTK6 Down-Regulation SRMS PTK6 PTPN1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.3 Calcitonin-like ligand receptors ADM RAMP1 CALCR CALCA IAPP CALCB RAMP2 CALCRL RAMP3 ADM2 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 80%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HERC2 PIAS4 RNF168 TP53 MRE11 MAPK8 CHEK2 UBE2N KAT5 UBE2I ATM SUMO1 NBN UBXN1 BARD1 BABAM1 BABAM2 UIMC1 BAZ1B ABRAXAS1 RNF8 BRCC3 KDM4B RAD50 APBB1 TP53BP1 KDM4A H2AX EYA1 EYA2 EYA3 EYA4 UBE2V2 PPP5C BAP1 H2BC12L H2BC21 UBA52 H2BU1 ABL1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 NSD2 UBB UBC H2BC9 RPS27A H4C9 H2BC8 H2BC5 H3-4 H2BC3 SMARCA5 H2BC1 MDC1 BRCA1 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 80%9006335 Signaling by Erythropoietin EPO PIK3CD IRS2 CRKL PIK3CB EPOR LYN SHC1 PIK3CG GAB1 PIK3R5 PIK3R1 VAV1 NRAS PIK3CA PLCG1 SOS1 HRAS STAT5A STAT5B PLCG2 RAPGEF1 JAK2 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%8848584 Wax and plasmalogen biosynthesis AWAT2 FAR2 GNPAT AWAT1 DHRS7B AGPS FAR1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.3 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 HSPA1A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 HSPA8 PSMB8 PSMB9 SEM1 EIF4G1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 HSPB1 UBB UBC RPS27A PABPC1 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.1 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.2 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.1 Scavenging by Class A Receptors FTL APOA1 HSP90B1 COL1A1 COL3A1 COL1A2 COL4A2 CALR COL4A1 MASP1 FTH1 MSR1 SCARA5 MARCO SCGB3A2 COLEC12 COLEC11 APOE APOB RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.1 Resistance of ERBB2 KD mutants to osimertinib CDC37 HSP90AA1 ERBB2 ERBIN LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 80%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 80%8949215 Mitochondrial calcium ion transport STOML2 MCUB SPG7 MAIP1 PHB2 PARL AFG3L2 SMDT1 PMPCB YME1L1 PMPCA MICU3 MICU2 MICU1 PHB1 MCU AKAP1 SLC8B1 VDAC3 LETM1 VDAC2 VDAC1 SLC8A3 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9755779.1 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAQ YWHAE YWHAG AKT2 YWHAH PDPK1 AKT1 AKT3 CAV1 SFN YWHAB YWHAZ SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.2 Signaling by ERBB2 TMD JMD mutants ERBB2 ERBIN SHC1 EGF EGFR NRAS NRG1 CDC37 PLCG1 SOS1 HRAS HSP90AA1 BTC NRG3 NRG4 NRG2 HBEGF EREG SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.4 Signaling by ERBB2 in Cancer PTPN12 ERBB2 ERBIN SHC1 EGF GAB1 PIK3R1 EGFR NRAS NRG1 PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 BTC NRG3 NRG4 NRG2 HBEGF EREG INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 80%909733 Interferon alpha beta signaling IRF1 IRF2 EGR1 USP18 ABCE1 BST2 PTPN6 KPNB1 XAF1 KPNA1 PTPN1 PSMB8 OASL ISG20 OAS1 IFNAR1 OAS2 OAS3 IFNA5 IFI35 IFNA4 IFNA7 RSAD2 IFNA6 IFI27 IFNA2 IRF4 IRF8 IRF5 IRF6 IFNA8 IRF9 GBP2 STAT1 IP6K2 SAMHD1 MX2 MX1 IFNA13 SOCS3 IFNA14 IFNA16 SOCS1 IFNA17 IRF3 IRF7 IFNA10 JAK1 IFI6 IFITM3 IFITM1 IFITM2 ADAR TYK2 IFIT5 IFIT1 IFIT3 IFIT2 IFNA21 IFNB1 ISG15 HLA-H HLA-B HLA-C RNASEL HLA-A HLA-F PTPN11 HLA-G HLA-E STAT2 DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 80%5083635 Defective B3GALTL causes PpS CFP ADAMTS4 ADAMTS5 ADAMTS1 SEMA5A ADAMTS8 SPON2 ADAMTS9 SEMA5B SPON1 THSD7B B3GLCT THBS2 ADAMTS12 THBS1 THSD1 THSD4 ADAMTS10 ADAMTSL1 ADAMTS15 ADAMTS2 ADAMTS14 ADAMTS3 ADAMTS13 ADAMTSL5 ADAMTSL4 ADAMTS19 ADAMTSL3 ADAMTSL2 ADAMTS17 THSD7A ADAMTS6 ADAMTS7 SBSPON SSPOP ADAMTS20 ADAMTS16 ADAMTS18 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 80%75064 mRNA Editing: A to I Conversion ADARB1 ADAR FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 80%112382 Formation of RNA Pol II elongation complex LEO1 EAF1 ELOB EAF2 PAF1 ELOC TCEA1 CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 ELOA2 CDK9 WDR61 CCNH SSRP1 CCNK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 SUPT5H ERCC3 ELL ERCC2 AFF4 CDC73 ELOA CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 PROGRAMMED CELL DEATH%REACTOME%R-HSA-5357801.2 Programmed Cell Death LMNB1 YWHAQ PRKCQ FLOT1 YWHAH GSN YWHAZ BAX BID ARHGAP10 UACA CDKN2A ROCK1 FLOT2 VIM DSP BCL2L1 DSG1 BAD CASP9 AKT3 XIAP TP53 YWHAE MAPK8 PELI1 KPNB1 LY96 CD14 CASP4 TLR4 YWHAG HSP90AA1 APAF1 CASP6 CASP1 STUB1 TP63 TP73 DYNLL1 HMGB1 CASP8 UBA52 CASP5 PDCD6IP BAK1 MLKL GZMB PRKCD TICAM1 OGT TRAF2 UBB UBC TNFSF10 RPS27A TP53BP2 MAGED1 BCL2L11 RIPK1 SFN FADD RIPK3 FNTA TNFRSF10B TNFRSF10A BBC3 TRADD FASLG CHMP2B CHMP4C BIRC2 CHMP2A BIRC3 DYNLL2 CHMP4B CHMP3 PSMD8 CHMP4A PSMD9 FAS CHMP6 PSMD6 CHMP7 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 IRF1 IRF2 GSDMD TICAM2 YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 TFDP1 PSMA2 AKT2 PSME3 TFDP2 PSME4 PSME1 IL18 AKT1 PSME2 IL1A IL1B PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PMAIP1 PSMB10 MAPK1 PSMA8 PSMB6 CTNNB1 MAPK3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 KPNA1 PSMB9 CYCS SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PPP1R13B PSMC2 UNC5A UNC5B PAK2 CDC37 CASP7 DIABLO SDCBP CDH1 DSG2 DCC DBNL ELANE DAPK1 DAPK2 DAPK3 OMA1 H1-1 PKP1 H1-0 H1-3 H1-2 H1-5 H1-4 OCLN NMT1 PPP3CC APPL1 DFFB CASP3 DFFA GAS2 MAPT SATB1 PTK2 CARD8 TJP1 BMF CLSPN BMX STK24 STK26 AVEN HMGB2 APIP OPA1 DNM1L PLEC ADD1 SPTAN1 ACIN1 DSG3 APC C1QBP BCAP31 BCL2 PPP3R1 STAT3 GSDME C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME DATABASE ID RELEASE 80%5621481 C-type lectin receptors (CLRs) IKBKB PSMD8 PSMD9 PSMD6 RAF1 PSMD7 PSMD4 PSMD5 PSMD2 CARD9 PSMD3 PSMD1 NFATC3 IKBKG MAP3K7 NFATC2 NFATC1 CHUK PYCARD PSMA5 CDC34 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 UBE2V1 PSME4 PSME1 PSME2 CARD11 PSMD10 IL1B PSMB11 PSMD12 CLEC4A PSMD11 CLEC4C PSMD14 CALM1 CLEC4D PSMD13 CLEC4E BCL10 PSMA7 RELA MALT1 PSMB10 PSMA8 CLEC7A PSMB6 LYN PSMB7 PSMB4 PSMB5 PSMB2 CLEC6A PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 UBE2N TAB3 PSMC5 TAB2 PSMC6 TAB1 PSMC3 PSMC4 PSMC1 PSMC2 MUC13 MUCL1 PAK1 PDPK1 MAP3K14 FYN TRAF6 PAK3 PAK2 NRAS HRAS PRKACG PRKACB MUC5AC UBA3 CD209 UBE2M AHCYL1 ICAM2 ICAM3 ITPR1 ITPR2 ITPR3 CREBBP EP300 PLCG2 SYK BTRC PRKACA PPP3CA SKP1 MUC12 MUC15 FCER1G FBXW11 RELB MUC1 MUC2 MUC7 CASP8 MUC4 UBA52 MUC6 PRKCD MUC3A MUC3B CUL1 UBB PPP3R1 MUC16 MUC17 UBC MUC19 RPS27A MUC20 MUC21 PPP3CB NFKB2 MUC5B UBE2D2 CLEC10A UBE2D1 RPS6KA5 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.2 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation TFAP2A MYBL2 NPM1 NOP2 HSPD1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-HSA-141405.4 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC11 CDC23 BUB1B CDC26 CDC20 CDC27 BUB3 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC15 UBE2D1 ANAPC1 ANAPC2 ANAPC16 ANAPC10 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.1 PIWI-interacting RNA (piRNA) biogenesis PLD6 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PIWIL2 TDRKH PIWIL1 PIWIL4 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 HSP90AA1 DDX4 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 80%2730905 Role of LAT2 NTAL LAB on calcium mobilization IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 PDPK1 V1-3 IGKV3D-20 V5-6 FYN IGHE IGLV3-19 PIK3R1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 PIK3CA IGHV3-48 IGLV3-25 IGLV3-27 SOS1 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PIK3R2 LAT2 PIK3CB GAB2 SYK IGHV3-23 IGLV IGLV2-8 IGKV1-16 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME DATABASE ID RELEASE 80%444411 Rhesus glycoproteins mediate ammonium transport. RHAG RHCG RHBG PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 80%5654221 Phospholipase C-mediated cascade; FGFR2 FGF22 FGF10 FGF16 FGF7 FGF18 PLCG1 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 80%192905 vRNP Assembly HSP90AA1 IPO5 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 80%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RPS27A SHC1 EGF GAB1 PIK3R1 UBA52 CBL EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 UBB UBC TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 80%5626978 TNFR1-mediated ceramide production SMPD3 SMPD2 NSMAF RACK1 TNF TNFRSF1A DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 80%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 80%9686347 Microbial modulation of RIPK1-mediated regulated necrosis MLKL CASP8 RIPK1 RIPK3 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 80%5668599 RHO GTPases Activate NADPH Oxidases PRKCA MAPK1 RAC2 NOXO1 PRKCZ PIK3C3 MAPK3 NOXA1 NOX3 RAC1 PIK3R4 NOX1 PRKCB S100A9 S100A8 CYBB PRKCD CYBA PIN1 MAPK14 NCF1 NCF2 MAPK11 NCF4 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 80%381183 ATF6 (ATF6-alpha) activates chaperone genes HSPA5 HSP90B1 NFYA NFYB DDIT3 CALR NFYC ATF6 ATF4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-HSA-186763.2 Downstream signal transduction CRKL PIK3CB PDGFRB GRB7 PDGFRA STAT1 PIK3R1 PDGFB SRC NRAS PIK3CA PLCG1 CRK SOS1 HRAS NCK2 NCK1 RAPGEF1 RASA1 STAT3 PIK3R2 STAT5A STAT5B PTPN11 STAT6 BCAR1 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 80%167242 Abortive elongation of HIV-1 transcript in the absence of Tat POLR2J POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NCBP1 NELFA NCBP2 NELFE SUPT5H POLR2A GTF2F1 POLR2B GTF2F2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.3 ERBB2 Regulates Cell Motility MEMO1 RHOA DIAPH1 ERBB2 EGF EGFR NRG1 BTC NRG3 NRG4 NRG2 HBEGF EREG TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.2 Toxicity of botulinum toxin type F (botF) SV2C SV2B SV2A VAMP2 VAMP1 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.2 rRNA processing in the mitochondrion MRM2 MRM3 TRMT10C ELAC2 PRORP HSD17B10 NSUN4 MTERF4 TFB1M MRM1 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 80%8985586 SLIT2:ROBO1 increases RHOA activity RHOA ROBO1 MYO9B SLIT2 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.1 HSF1 activation VCP EEF1A1 YWHAE HSP90AB1 RPA3 RPA1 HSP90AA1 HSBP1 HSF1 PTGES3 RPA2 HDAC6 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.3 Processing of Capped Intron-Containing Pre-mRNA TXNL4A SNRNP35 SNRPN ZCRB1 WBP11 NUP62 NUP214 PRPF4 NDC1 PRPF6 HNRNPUL1 SEC13 PRPF3 NUP210 SNRNP27 PPIH SNRNP25 NUP133 SNRNP200 SNRPC SNRPA PRPF8 ZMAT5 CPSF4 NUP93 CPSF1 FUS CPSF3 CPSF2 CWC15 NUP50 CHERP NUP54 LSM8 NUP205 ISY1 POM121 DDX46 DDX42 PPWD1 AAAS USP39 NUP160 ELAVL1 ELAVL2 SART1 METTL14 POM121C SNRNP70 BCAS2 NUP42 NUP85 RBM5 CTNNBL1 RBM17 TPR BUD31 NUP88 TFIP11 PLRG1 NUP43 RAE1 SYF2 RANBP2 DNAJC8 RBM22 WBP4 PRCC TRA2B DDX23 NUP155 CSTF2T PABPN1 PUF60 SNRPB2 SMNDC1 HNRNPA0 NUP153 HNRNPA3 PPIL1 WTAP GPKOW CDC5L U2SURP SNRNP40 NUP35 SNRNP48 NUP37 PPIL3 PPIL4 PPIL6 RBMX POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L NXT1 EIF4A3 CASC3 GLE1 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 PTBP1 SNW1 GTF2F1 GTF2F2 HNRNPH1 HNRNPA1 HNRNPM HNRNPF SNRPD2 SNRPD1 SNRPD3 SNRPG SNRPE SNRPF SNRPB LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 FIP1L1 PCBP2 HNRNPC HNRNPA2B1 SNRPA1 YBX1 EIF4E DHX9 HSPA8 DDX5 HNRNPU HNRNPR CCAR1 CLP1 SRRM2 AQR METTL3 CRNKL1 CD2BP2 SF1 SLBP CSTF3 CSTF2 SNU13 PPIE RNPC3 PCBP1 CSTF1 SYMPK ZRSR2 PRPF38A HNRNPL HNRNPK HNRNPD SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 SRSF10 SF3A3 SF3A1 SF3A2 NUDT21 XAB2 PHF5A PRPF31 PDCD7 NUP107 CWC25 NUP188 CWC27 CPSF7 EFTUD2 CWC22 PAPOLA MTREX ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 80%399997 Acetylcholine regulates insulin secretion MARCKS PLCB3 GNAQ PRKCA GNA14 PLCB1 PLCB2 CHRM3 GNA15 GNA11 PECAM1 INTERACTIONS%REACTOME%R-HSA-210990.1 PECAM1 interactions ITGB3 PECAM1 PLCG1 YES1 PTPN6 ITGAV LCK LYN PTPN11 FYN INPP5D CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME DATABASE ID RELEASE 80%204998 Cell death signalling via NRAGE, NRIF and NADE TIAM2 BAD SQSTM1 FGD1 FGD2 FGD3 ARHGEF10L FGD4 KALRN MCF2L CASP3 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 NET1 ARHGEF17 ARHGEF16 ARHGEF19 VAV3 ARHGEF18 AKAP13 YWHAE MAPK8 GNA13 ARHGEF9 ARHGEF3 ARHGEF4 OBSCN ARHGEF1 ARHGEF2 TRIO ARHGEF7 ARHGEF5 ARHGEF6 CASP2 PLEKHG5 PREX1 ITSN1 RAC1 TRAF6 VAV1 UBA52 RASGRF2 SOS1 VAV2 TIAM1 ITGB3BP UBB PLEKHG2 NGEF UBC ARHGEF40 RPS27A NGFR NGF SOS2 BEX3 APH1A PSENEN MAGED1 ARHGEF26 APH1B PSEN2 ABR BCL2L11 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 PSEN1 AATF ECT2 NCSTN ARHGEF39 MCF2 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME DATABASE ID RELEASE 80%9668250 Defective factor IX causes hemophilia B GP9 GGCX F8 F10 F9 GP1BB F11 GP1BA GP5 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.3 Binding of TCF LEF:CTNNB1 to target gene promoters TCF7L2 TCF7L1 MYC TCF7 AXIN2 LEF1 CTNNB1 RUNX3 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 80%6783783 Interleukin-10 signaling CD86 IL1RN CCL19 ICAM1 CCL22 CCL20 CD80 IL1R1 LIF IL1R2 CCR1 CXCL8 CXCL1 CXCL2 TIMP1 IL18 TNF IL1A FPR1 IL1B IL10RB IL10RA CXCL10 CSF3 IL12B IL12A CSF2 CSF1 JAK1 PTAFR STAT3 TNFRSF1B CCL5 CCL4 TYK2 CCL3 IL10 CCL2 IL6 CCL3L3 CCR5 CCR2 PTGS2 TNFRSF1A FCER2 KERATAN SULFATE DEGRADATION%REACTOME DATABASE ID RELEASE 80%2022857 Keratan sulfate degradation HEXB GNS HEXA ACAN LUM OGN OMD KERA PRELP FMOD GLB1L GLB1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.1 Toll Like Receptor TLR1:TLR2 Cascade RPS6KA2 IKBKB RPS6KA1 ATF1 SIGIRR IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 UBE2V1 RIPK2 IRAK3 NOD1 NOD2 PPP2CA RELA PPP2CB MAPK1 MAPK3 NFKB1 NFKBIA MAP2K3 UBE2N TAB3 TAB2 TAB1 NFKBIB MAPK11 TRAF6 SOCS1 MAP2K1 TNIP2 MAP3K8 IRAK2 ATF2 BTK S100A9 S100A8 MAP2K4 MAPK14 MAP2K7 JUN FOS MAPK9 MAPK8 MAPK10 IRAK1 PELI3 PELI2 PELI1 PPP2R1A LY96 CD14 S100A1 MYD88 DUSP4 BTRC DUSP3 TIRAP PPP2R5D TLR1 VRK3 DUSP6 TLR6 DUSP7 TLR4 MAPK7 PPP2R1B IRAK4 TLR2 SKP1 FBXW11 APP FGB FGA HMGB1 FGG UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB UBC RPS27A AGER S100A12 CD36 ECSIT MAP3K1 S100B NFKB2 SAA1 MEF2A MEF2C RPS6KA3 RPS6KA5 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 80%8868773 rRNA processing in the nucleus and cytosol RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 DKC1 IMP4 NHP2 RRP7A PDCD11 ERI1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 GAR1 TRMT112 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 RRP36 UTP6 NOP10 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL RPP38 DIMT1 FTSJ3 EBNA1BP2 NCL RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 UTP18 SENP3 C1D DDX21 BMS1 RPP14 DCAF13 NOP58 KRR1 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 CSNK1D EXOSC2 CSNK1E EXOSC1 UBA52 RPS27A RPS6 XRN2 NOP2 SNU13 RPL4 RPL5 NOP56 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 MTREX TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 80%1296346 Tandem pore domain potassium channels KCNK2 KCNK4 KCNK6 KCNK7 KCNK13 KCNK9 KCNK16 KCNK17 KCNK18 KCNK1 KCNK10 KCNK3 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 80%8964540 Alanine metabolism GPT REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.1 Regulation of TP53 Degradation RFFL PDPK1 MAPKAP1 CCNA2 CCNA1 AKT3 CCNG1 DAXX UBA52 AKT2 MLST8 AKT1 RICTOR CDK2 USP7 UBB TP53 UBC PPP2CA PPP2CB RPS27A MTOR USP2 PPP2R1A PRR5 PHF20 CHEK2 CDKN2A CDK1 PPP2R1B MDM2 MDM4 ATM RNF34 PPP2R5C SGK1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-HSA-425393.2 Transport of inorganic cations anions and amino acids oligopeptides CALM1 SLC15A4 SLC4A7 SLC36A1 SLC36A2 SLC8B1 SLC1A5 SLC8A1 SLC8A2 SLC17A5 SRI SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC4A1 SLC9A8 SLC9A9 SLC34A3 SLC9A1 SLC34A2 SLC34A1 SLC8A3 AHCYL2 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC26A11 SLC6A19 SLC12A6 SLC6A18 SLC12A7 SLC6A15 SLC38A1 SLC15A1 SLC15A2 SLC6A14 SLC5A8 SLC6A12 SLC26A2 SLC26A1 SLC1A1 SLC6A20 SLC1A2 SLC1A3 SLC1A4 SLC1A6 SLC1A7 SLC6A6 SLC5A5 SLC38A3 SLC15A3 SLC38A2 SLC38A5 SLC38A4 SLC4A10 SLC16A10 SLC26A7 SLC26A9 SLC26A4 SLC26A3 SLC26A6 SLC7A11 SLC7A10 SLC32A1 SLC7A5 SLC7A6 SLC25A18 SLC7A9 SLC7A7 SLC3A1 SLC7A8 SLC25A10 SLC24A2 SLC24A1 SLC24A4 SLC24A3 SLC43A2 SLC20A2 SLC20A1 SLC43A1 SLC5A12 SLC3A2 SLC7A1 SLC7A3 SLC25A26 SLC25A29 SLC17A6 SLC17A7 SLC17A8 SLC17A1 SLC36A4 SLC25A22 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 CTNS SLC4A8 SLC4A9 SLC24A5 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%5652227 Fructose biosynthesis SORD AKR1B1 ACETYLATION%REACTOME DATABASE ID RELEASE 80%156582 Acetylation NAT1 NAT2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 80%429958 mRNA decay by 3' to 5' exoribonuclease DCPS EXOSC2 EXOSC1 HBS1L TTC37 DIS3 NT5C3B WDR61 SKIV2L EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 80%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint ANAPC11 PSMD8 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NEK2 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 UBA52 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 CDK1 UBE2D1 ANAPC15 ANAPC16 ANAPC10 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.1 Constitutive Signaling by AKT1 E17K in Cancer PDPK1 GSK3A MAPKAP1 BAD CASP9 AKT3 CHUK AKT2 MLST8 FOXO3 AKT1 RICTOR CREB1 TSC2 MTOR FOXO6 FOXO4 FOXO1 NR4A1 AKT1S1 PRR5 GSK3B MDM2 CDKN1A RPS6KB2 CDKN1B BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.3 Beta oxidation of butanoyl-CoA to acetyl-CoA ECHS1 ACSM3 HADH ACSM6 ACADS ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 80%9028335 Activated NTRK2 signals through PI3K PIK3CA BDNF NTRK2 GAB1 PIK3R1 NTF4 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 80%4086398 Ca2+ pathway PRKCA ITPR1 ITPR2 ITPR3 MAP3K7 MOV10 NFATC1 CAMK2A CALM1 TCF7L2 TCF7L1 TCF7 LEF1 CTNNB1 AGO3 GNG10 AGO4 AGO1 AGO2 GNG12 GNG11 GNG13 PPP3CA GNB2 GNB1 GNB4 GNB3 TNRC6C GNB5 GNGT1 TNRC6A TNRC6B GNGT2 PLCB3 PLCB1 PLCB2 GNG3 GNG2 GNG5 GNG4 PPP3R1 GNG7 GNG8 PPP3CB GNAT2 PRKG1 WNT5A PRKG2 NLK WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 PDE6G FZD4 FZD6 GNAO1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.2 RNA Polymerase III Chain Elongation POLR3F POLR2K POLR3G POLR2L POLR3H POLR3K POLR3GL POLR1C POLR1D CRCP POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%209931 Serotonin and melatonin biosynthesis DDC TPH1 AANAT ASMT TPH2 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 80%198765 Signalling to ERK5 MAPK7 MAP2K5 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 80%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane C2CD5 RALGAPA2 TBC1D1 RALGAPB TBC1D4 PRKAA2 STXBP3 RAB4A ASPSCR1 YWHAB RAB13 PRKAG1 PRKAG2 LNPEP PRKAG3 YWHAQ AKT2 YWHAH AKT1 PRKAB2 CALM1 YWHAZ MYO5A YWHAE PRKAB1 STX4 RAB8A YWHAG RHOQ SNAP23 KIFAP3 RAC1 EXOC8 EXOC7 KIF3B RALA EXOC4 EXOC3 EXOC6 RAB10 EXOC5 EXOC2 EXOC1 SLC2A4 KIF3A SFN RAB11A MYH9 VAMP2 MYO1C NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 80%112311 Neurotransmitter clearance SLC6A4 SLC6A3 MAOA BCHE SLC22A2 SLC22A1 ACHE ALDH2 COMT TOMT TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.5 TAK1-dependent IKK and NF-kappa-B activation IKBKB HMGB1 TRAF6 IKBKG MAP3K7 CHUK NKIRAS1 NKIRAS2 RIPK2 UBE2V1 NOD1 NOD2 RELA IRAK2 AGER IRAK1 S100A12 NFKB1 NFKBIA UBE2N S100B TAB3 NFKB2 TAB2 TAB1 SAA1 NFKBIB APP REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 80%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PRKACG PFKFB2 PPP2CB PRKACB PFKFB1 PFKFB4 PPP2R1B PFKFB3 PPP2R1A PPP2R5D PRKACA SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.6 Smooth Muscle Contraction MYL12A TLN1 PAK1 VCL MYLK PAK2 MYL12B ITGB5 TRIM72 PXN DYSF ANXA1 LMOD1 MYL6B ACTG2 CALD1 MYL6 ANXA6 MYL10 CALM1 CAV3 MYL9 TPM2 TPM1 SORBS1 SORBS3 ACTA2 MYLPF ANXA2 MYL5 MYL7 GUCY1B2 GUCY1B1 TPM4 TPM3 ITGA1 GUCY1A2 MYH11 GUCY1A1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.2 Synthesis of PIPs in the nucleus PIP4K2C PIP4P1 PIP4K2A PIP4K2B RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) CBFB TNFRSF18 IL2 IL2RA FOXP3 NFATC2 CTLA4 CR1 IFNG RUNX1 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.1 Constitutive Signaling by Overexpressed ERBB2 CDC37 PTPN12 SOS1 HRAS HSP90AA1 ERBB2 ERBIN SHC1 NRAS NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 80%375165 NCAM signaling for neurite out-growth NCAM1 COL9A1 COL9A3 NRTN COL9A2 SPTBN2 SPTBN1 CACNA1D CACNA1C CACNA1H CACNA1G PTK2 SPTA1 CACNA1I CACNA1S PRNP PTPRA MAPK1 CACNB1 CNTN2 SPTAN1 GFRA1 CACNB2 MAPK3 CACNB3 SPTB CACNB4 GFRA2 GFRA4 FYN COL4A2 COL4A1 COL6A2 NRAS COL4A4 COL6A1 SOS1 HRAS COL4A3 NCAN COL6A3 CREB1 ST8SIA4 COL4A5 COL6A6 COL6A5 PSPN ST8SIA2 ARTN GDNF AGRN SPTBN4 SPTBN5 RPS6KA5 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 80%6802957 Oncogenic MAPK signaling CNKSR1 KRAS TLN1 RAF1 VCL CAMK2B AGK CAMK2D YWHAB ATG7 SRC CAMK2A ESRP1 CALM1 SPRED3 CAMK2G SPRED2 BRAF SPRED1 MAPK1 PPP1CB MAPK3 PPP1CC TENT4A DUSP16 KIAA1549 DUSP10 NF1 MPRIP AGTRAP AP3B1 DUSP8 DUSP9 DUSP6 SND1 DUSP7 MRAS KDM7A FAM114A2 ZC3HAV1 PAPSS1 FXR1 LMNA SHOC2 QKI CLCN6 FAM131B AGGF1 TRAK1 FGB FGA VWF TRIM24 AKAP9 FGG NRAS MAP3K11 HRAS MAP2K1 IQGAP1 BCL2L11 PHB1 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.2 Potassium Channels KCNQ4 KCNJ8 KCNJ11 ABCC8 ABCC9 KCNK10 KCNK2 KCNK4 KCNAB2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNN1 KCNN3 KCNN4 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNJ2 KCNJ3 KCNJ4 GABBR2 KCNJ5 KCNN2 GABBR1 KCNJ10 KCNJ12 KCNJ9 KCNB1 KCNB2 KCNJ14 KCNJ15 KCNJ16 KCNS1 KCNS2 KCNS3 HCN2 HCN1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNK7 KCNK9 KCNK16 KCNK17 KCNK18 KCNK1 KCNK3 GNG10 KCNK13 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNQ2 KCNQ3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.3 Defective GALE causes EDG GALE INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 80%9014826 Interleukin-36 pathway IL36A IL36B IL36RN IL1RL2 IL36G IL1F10 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.2 Physiological factors CORIN KAT2B HIPK1 GATA4 HIPK2 NPPC NPR1 NPR2 WWTR1 NPPA TBX5 NKX2-5 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 80%167152 Formation of HIV elongation complex in the absence of HIV Tat CCNH ELOB ELOC TCEA1 SSRP1 CCNT2 CCNT1 CCNK POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 ELOA2 SUPT5H CDK9 ERCC3 ELL ERCC2 ELOA NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 80%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL2 CCDC88C DVL3 CXXC4 DVL1 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.1 MECP2 regulates transcription of neuronal ligands BDNF HDAC1 SIN3A SST CRH CREB1 DLL1 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013148 CDC42 GTPase cycle ARHGAP27 CDC42EP5 ARHGAP24 CDC42EP4 CDC42EP3 ARHGAP33 CDC42EP2 ARHGAP31 DNMBP FGD1 ARHGAP30 FGD2 FGD3 FGD4 CHN1 MCF2L FARP1 ARHGEF11 ARHGEF10 DEF6 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF19 SHKBP1 ARAP1 ARHGAP10 FAM13B GOLGA8R GNA13 LAMTOR1 STOM TRIO TFRC FMNL3 SNAP23 FMNL1 FMNL2 ARHGAP1 ARHGAP39 ARHGAP5 ARHGAP35 SRGAP3 CDC42 DOCK10 SRGAP1 PAK1 SYDE1 PREX1 ARHGAP42 SCRIB PLD1 OPHN1 PAK3 ARHGDIB PAK2 KTN1 PIK3R1 LBR MAP3K11 GIT1 TMPO ARHGAP11B ARAP2 RASGRF2 TAGAP ARAP3 VAV2 BCR PLEKHG3 TIAM1 DEPDC1B PLEKHG4 PLEKHG1 PLEKHG2 CDC42EP1 ARFGAP3 RAB7A VAMP3 ARHGDIA ARFGAP2 PIK3R2 ARHGAP17 ABR ARHGAP21 PARD6A RACGAP1 SRGAP2 YKT6 PAK4 CDC42BPB CDC42BPA GIT2 CPNE8 CAV1 MCF2 ARHGAP26 BAIAP2 SPATA13 VANGL1 ARHGAP32 DIAPH3 VAV3 WASL SH3PXD2A ARHGEF9 ARHGEF4 DOCK11 ARHGEF7 ARHGEF5 ARHGEF6 WAS PLEKHG4B WIPF1 WIPF2 PAK6 ITSN1 WIPF3 PAK5 FNBP1L PREX2 MYO9B WDR91 DLC1 FNBP1 STARD8 STEAP3 ARHGDIG DAAM1 ARHGAP44 WDR81 ARHGAP40 NGEF RALBP1 KCTD3 IQGAP1 ARHGAP45 IQGAP2 IQGAP3 DOCK6 ARHGEF26 ARHGEF25 DOCK9 DOCK8 DOCK7 STARD13 JUP CDC42SE2 ARHGAP22 ARHGAP9 ARHGAP20 ECT2 ARHGAP4 GMIP ARHGAP29 PI3K CASCADE%REACTOME%R-HSA-109704.5 PI3K Cascade IRS1 TRIB3 FLT3 PIK3CB PDPK1 PIK3R4 FLT3LG GAB1 GAB2 PIK3R1 TLR9 KLB PIK3CA AKT2 FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 IRS2 FGF19 PIK3C3 PIK3R2 FGFR4 THEM4 FGF16 FGF7 FGF18 PDE3B PTPN11 DEFECTIVE HEXB CAUSES GM2G2%REACTOME DATABASE ID RELEASE 80%3656248 Defective HEXB causes GM2G2 HEXB DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.3 Diseases associated with O-glycosylation of proteins GALNT12 POMT2 CFP POMT1 LFNG C1GALT1C1 LARGE1 POMGNT1 C1GALT1 ADAMTS4 NOTCH1 B4GAT1 ADAMTS5 ADAMTS1 SEMA5A ADAMTS8 ADAMTS9 GALNT3 MUC12 MUC15 MUC13 MUCL1 MUC1 MUC2 MUC7 MUC4 NOTCH2 NOTCH3 NOTCH4 MUC6 MUC3A MUC3B SPON2 SEMA5B SPON1 MUC16 THSD7B MUC17 B3GLCT THBS2 MUC19 ADAMTS12 THBS1 THSD1 THSD4 ADAMTS10 MUC20 ADAMTSL1 MUC21 DAG1 ADAMTS15 ADAMTS2 MUC5AC ADAMTS14 ADAMTS3 ADAMTS13 ADAMTSL5 ADAMTSL4 ADAMTS19 ADAMTSL3 ADAMTSL2 ADAMTS17 THSD7A ADAMTS6 ADAMTS7 MUC5B SBSPON SSPOP ADAMTS20 ADAMTS16 ADAMTS18 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.1 Defective F8 cleavage by thrombin F8 VWF F2 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.1 Ligand-receptor interactions IHH GAS1 CDON DHH SHH HHIP PTCH1 BOC SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702624 sorafenib-resistant FLT3 mutants FLT3 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 80%351200 Interconversion of polyamines SAT1 PAOX DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.2 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.3 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB POLA1 POLA2 E2F1 PPP2R1A PRIM2 TFDP1 PRIM1 PPP2R1B TFDP2 RB1 PPP2R3B RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.1 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function MOV10 KMT2D KMT2C H3C15 KAT2B PRKCQ PRMT6 NR4A3 EP300 AGO3 AGO4 AGO1 RUNX1 KMT2A CBFB TNRC6C WDR5 TNRC6A PRMT1 TNRC6B HDAC1 SIN3A H2AX H3-3B ZFPM1 H2AB1 H2AC19 SIN3B H2AC14 H2BC12L GP1BA H2BC21 GATA1 KMT2E H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 KMT2B NFE2 H2BC13 DPY30 H2BC14 RBBP5 H2AJ H2BC15 PF4 H2BC11 MYL9 H2AZ1 THBS1 H2BC9 SETD1B H2AZ2 SETD1A H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ITGA2B H2AC20 H3C8 ASH2L INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.2 Incretin synthesis, secretion, and inactivation TCF7L2 SEC11A LEP SEC11C GIP CTNNB1 GATA4 ISL1 PAX6 GNG13 GNAT3 GNB1 PCSK1 CDX2 GNB3 GRP GPR119 GCG DPP4 SPCS3 SPCS2 SPCS1 FFAR4 FFAR1 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 80%4551638 SUMOylation of chromatin organization proteins BMI1 SUMO3 SUMO2 NUP62 NUP214 NDC1 SEC13 NUP210 RING1 NUP133 HDAC2 PIAS1 NUP93 NUP50 SATB1 NUP54 NUP205 SUZ12 POM121 AAAS NUP160 RNF2 HDAC4 POM121C L3MBTL2 NUP42 SATB2 NUP85 ZBED1 TPR NUP88 NUP43 RAE1 RANBP2 CBX8 PHC2 PHC1 CHD3 NUP155 CBX4 CBX2 PCGF2 UBE2I NUP153 SUMO1 PHC3 NUP35 NUP37 HDAC1 CBX5 H4C9 NUP107 NUP188 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.1 Regulation of TP53 Expression PRDM1 TP53 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 80%69541 Stabilization of p53 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PHF20 PSMB9 CHEK2 SEM1 COP1 CDKN2A PSMC5 PSMC6 PSMC3 MDM2 PSMC4 MDM4 PSMC1 ATM PSMC2 UBA52 UBB UBC RPS27A SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.2 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 80%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 80%877300 Interferon gamma signaling NCAM1 HLA-DPB1 ICAM1 MT2A HLA-DQA2 TRIM29 IRF1 CAMK2B HLA-DQA1 IRF2 TRIM26 CAMK2D TRIM22 CAMK2A HLA-DRB5 HLA-DRB4 PIAS1 TRIM17 TRIM14 TRIM10 HLA-DQB2 HLA-DQB1 SP100 HLA-DRB3 HLA-DRB1 CAMK2G HLA-DRA PTPN6 PTAFR MID1 FCGR1A CD44 FCGR1BP PTPN1 OASL SUMO1 OAS1 OAS2 PML OAS3 IFI30 B2M IRF4 IRF8 IRF5 IRF6 IRF9 GBP2 GBP1 GBP4 GBP3 TRIM25 CIITA GBP6 GBP5 SOCS3 GBP7 PRKCD SOCS1 TRIM68 VCAM1 IRF3 IRF7 TRIM62 JAK1 HLA-DPA1 IFNG TRIM8 TRIM6 TRIM46 TRIM5 TRIM48 TRIM2 HLA-H HLA-B TRIM45 TRIM3 HLA-C HLA-A HLA-F PTPN11 IFNGR1 HLA-G TRIM35 TRIM21 HLA-E IFNGR2 TRIM38 TRIM31 TRIM34 JAK2 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.3 Signaling by CTNNB1 phospho-site mutants PPP2CA PPP2CB AMER1 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.1 ERBB2 Activates PTK6 Signaling NRG1 BTC NRG3 ERBB2 NRG4 PTK6 NRG2 EGF HBEGF EREG EGFR SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.4 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) TCF7L2 SEC11A LEP SEC11C CTNNB1 PAX6 GNG13 GNAT3 GNB1 PCSK1 CDX2 GNB3 GRP GPR119 GCG DPP4 SPCS3 SPCS2 SPCS1 FFAR4 FFAR1 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 80%1221632 Meiotic synapsis LMNB1 SMC1A RAD21 SYCP2 SYCP1 SYNE2 SYNE1 SUN2 SUN1 TEX12 SMC1B HSPA2 SYCE3 SYCE2 SYCE1 REC8 STAG3 SYCP3 FKBP6 UBE2I STAG1 STAG2 H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 ATR H2AC20 BRCA1 SMC3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 80%199418 Negative regulation of the PI3K AKT network INSR SRC NRG1 AKT2 AKT1 PPP2CA PPP2CB MAPK1 MAPK3 KIT CD86 LCK CD80 CD28 FYN RAC1 TRAF6 EGF GAB1 PIK3R1 VAV1 EGFR PIK3CA BTC NRG3 NRG4 NRG2 HBEGF EREG PIK3R2 PPP2R5E PPP2R5B PPP2R5A PPP2R5C PIP4K2A PIP4K2B PIP4K2C IER3 IRS1 TRIB3 PIK3CD FLT3 PIK3CB AREG PDGFRB PIP5K1A PDGFRA PIP5K1B HGF PIP5K1C AKT3 FLT3LG PIK3R3 GAB2 MET PDGFB TGFA KLB CD19 TRAT1 ESR1 PHLPP2 ESR2 PHLPP1 EPGN STRN PIK3AP1 IL33 IL1RL1 IRS2 IRAK1 FGF19 RAC2 FGFR4 THEM4 PPP2R1A FGF16 RHOG FGF7 FGF18 MYD88 PTEN PPP2R5D PPP2R1B IRAK4 FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 ERBB2 INS PTPN11 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.5 Regulation of Complement cascade IGKV1-17 IGKV1-12 IGHV3-7 CFH IGHV3-9 V2-11 CFI IGHV3-30 V3-4 V3-3 V2-17 C3AR1 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CPB2 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 VTN IGKV3-15 IGKV3-11 CLU V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 C4B_2 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 CR2 IGHV2-5 CR1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1S C1R CD46 C5AR2 ELANE C5AR1 C4A CPN2 CPN1 CD59 CD19 C1QB CD55 C1QA C1QC CD81 C3 C8B CFB C8A C8G PROS1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 F2 C4BPA C4BPB SERPING1 C2 C5 C6 C7 C9 IGHV3-23 IGLV IGLV2-8 IGKV1-16 HYPUSINYLATION%REACTOME%R-HSA-204626.1 Hypusinylation EIF5A DHPS EIF5A2 DOHH MTF1 ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-5660489.1 MTF1 activates gene expression CSRP1 MTF1 SNCB DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 80%5660724 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 80%8957275 Post-translational protein phosphorylation CP LTBP1 DNAJC3 AHSG FUCA2 IGFBP3 CSF1 MEN1 MSLN PCSK9 HSP90B1 CKAP4 KTN1 SDC2 BPIFB2 VCAN GPC3 QSOX1 ADAM10 IL6 MELTF APOE APOB MBTPS1 APOA2 APOA1 C4A APOA5 LAMC1 ALB P4HB CST3 TIMP1 CDH2 PNPLA2 C3 SERPINC1 SPP1 TNC KNG1 LAMB1 DMP1 LGALS1 APP EVA1A CCN1 CHGB IGFBP1 IGFBP5 FGA IGFBP4 APLP2 SHISA5 SERPIND1 PDIA6 MXRA8 SPARCL1 PRKCSH SCG3 SCG2 FGG TGOLN2 STC2 PENK IGFBP7 AMELX F5 WFS1 AMBN TMEM132A BMP4 TF PROC CALU HRC FBN1 SERPINA10 MIA3 CHRDL1 PRSS23 BMP15 ANO8 MEPE FGF23 RCN1 VGF ENAM MGAT4A AMTN VWA1 FAM20C FAM20A MFGE8 GAS6 MATN3 ITIH2 AFP FSTL1 FSTL3 SPP2 SERPINA1 APOL1 LAMB2 GOLM1 NUCB1 NOTUM FN1 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.3 Virus Assembly and Release CANX CALR DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 80%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 80%418217 G beta:gamma signalling through PLC beta PLCB3 GNGT2 PLCB1 PLCB2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNG3 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 80%169893 Prolonged ERK activation events MAPK1 NGF CRKL MAPK3 YWHAB NTRK1 CRK KIDINS220 FRS2 RAP1A MAP2K2 RAPGEF1 MAP2K1 BRAF CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 80%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKACG PRKACB ADCY1 PRKX ADCY8 PRKAR1B PRKAR1A CREB1 PRKAR2B PRKAR2A CALM1 PRKACA PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 80%75067 Processing of Capped Intronless Pre-mRNA CLP1 CPSF4 CPSF1 SLBP CSTF3 CPSF3 CSTF2 CPSF2 CSTF1 SYMPK FIP1L1 PCF11 WDR33 NCBP1 NCBP2 CSTF2T PABPN1 SNRPD3 ZNF473 LSM10 LSM11 NUDT21 SNRPG SNRPE CPSF7 SNRPF SNRPB PAPOLA FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.2 FOXO-mediated transcription CITED2 AKT3 CREBBP YWHAB TXNIP HDAC2 YWHAQ STK11 KAT2B AKT2 EP300 AKT1 YWHAZ FOXO6 FOXO4 FOXO1 PLXNA4 YWHAG SMAD2 PCBP4 SMAD3 NFYA NFYB DDIT3 NFYC NR3C1 RBL2 IGFBP1 SREBF1 HDAC1 SIN3A BCL6 GADD45A SIRT1 ATXN3 PPARGC1A SMAD4 FOXO3 PCK1 G6PC1 POMC KLF4 FBXO32 BCL2L11 SOD2 SFN CAT INS RETN BBC3 TRIM63 BTG1 FASLG MSTN SIRT3 FOXG1 NPY CDKN1A ABCA6 CAV1 PINK1 CDKN1B GCK CCNG2 AGRP RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013149 RAC1 GTPase cycle CIT ARHGAP27 ARHGAP25 ARHGAP24 CDC42EP4 ARHGAP23 ARHGAP33 ARHGAP31 ARHGAP30 DOCK2 FGD5 DOCK1 CHN2 CHN1 MCF2L FARP2 FARP1 ARHGEF11 ARHGEF10 DEF6 ARHGEF15 ARHGEF19 ARHGEF18 ARAP1 PKN2 PKN1 ARHGAP10 FAM13B ALS2 FAM13A GNA13 LAMTOR1 ITGB1 NCKAP1 CYFIP1 TRIO NCF1 TFRC NCF2 SNAP23 FMNL1 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP35 SRGAP3 CDC42 DOCK10 SRGAP1 PAK1 PREX1 ARHGAP42 BAIAP2L1 PLD1 OPHN1 RAC1 PLD2 PAK3 ARHGDIB PAK2 KTN1 NISCH PIK3R1 VAV1 EMD LBR GIT1 TMPO PIK3CA SWAP70 ARAP2 CYBB RASGRF2 SOS1 TAGAP ARAP3 CYBA VRK2 LEMD3 VAV2 BCR PLEKHG3 TIAM1 DEPDC1B PLEKHG4 PLEKHG1 PLEKHG2 CDC42EP1 PLEKHG6 RAB7A EPHA2 VAMP3 ARHGDIA GARRE1 AMIGO2 NOXO1 PIK3R2 ARHGAP17 SLC1A5 SOS2 ARHGAP15 ABR ARHGAP21 PARD6A RACGAP1 SH3BP1 NHS ABL2 NCKAP1L WASF3 WASF1 SRGAP2 WASF2 YKT6 PAK4 CDC42BPA GIT2 JAG1 CAV1 MCAM MCF2 ARHGAP26 TIAM2 BAIAP2 MPP7 SPATA13 VANGL1 ARHGAP32 DIAPH3 TAOK3 ABI2 ABI1 NOXA1 NOX3 ESYT1 PIK3R3 NOX1 FERMT2 KALRN VAV3 WASL ARHGEF4 DOCK11 ARHGEF7 ARHGEF5 ARHGEF6 WAS CYFIP2 WIPF1 WIPF2 PAK6 WIPF3 PAK5 PREX2 MYO9B DLC1 SYDE2 ARHGAP44 NGEF RALBP1 IQGAP1 ARHGAP45 IQGAP2 IQGAP3 DOCK6 DOCK5 ERBIN DOCK4 DOCK3 ARHGEF25 DOCK9 DOCK8 DOCK7 ARHGAP12 ARHGAP22 ARHGAP9 ARHGAP20 ECT2 ARHGAP4 ARHGEF39 GMIP ARHGAP29 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 80%4641257 Degradation of AXIN PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 RNF146 PSMD14 PSMD13 PSMA7 TNKS PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 TNKS2 PSMC2 AXIN1 AXIN2 UBA52 SMURF2 UBB UBC RPS27A DEFECTIVE SLC6A18 MAY CONFER SUSCEPTIBILITY TO IMINOGLYCINURIA AND OR HYPERGLYCINURIA%REACTOME DATABASE ID RELEASE 80%5619079 Defective SLC6A18 may confer susceptibility to iminoglycinuria and or hyperglycinuria SLC6A18 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 80%9748787 Azathioprine ADME GSTM1 TPMT ABCC5 GMPS NME1 SLC28A2 GUK1 SLC29A1 GSTA1 RAC1 SLC29A2 SLC28A3 VAV1 HPRT1 GSTA2 XDH NME2 IMPDH1 NUDT15 VAV2 IMPDH2 VAV3 ABCC4 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 80%9617828 FOXO-mediated transcription of cell cycle genes RBL2 FOXO4 FOXO1 GADD45A SMAD2 SMAD4 SMAD3 PCBP4 BTG1 FOXO3 MSTN FOXG1 CDKN1A CAV1 CDKN1B CCNG2 KLF4 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.1 Growth hormone receptor signaling IRS1 MAPK1 PTPN6 IRS2 STAT3 MAPK3 LYN STAT1 PTPN1 ADAM17 SOCS3 STAT5A SOCS2 SOCS1 STAT5B CSH1 CISH PRL PRLR GH2 GHR GH1 JAK2 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.1 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 80%5656121 Translesion synthesis by POLI RPA3 RPS27A REV1 MAD2L2 REV3L POLI UBA52 PCNA RPA1 RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.2 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ELAC2 ANG DICER1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 80%9660537 Signaling by MRAS-complex mutants MRAS ARAF RAF1 PPP1CB PPP1CC SHOC2 YWHAB BRAF HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 80%3214815 HDACs deacetylate histones H2AW HDAC10 H2AC17 H2AC12 HDAC2 H2AC1 H2BC18 H3C15 HDAC8 H2AC21 MBD3 GATAD2B GATAD2A CHD4 CHD3 KDM1A MTA1 MTA2 MTA3 REST NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 ARID4B GPS2 H2AC19 TBL1X H2AC14 H2BC21 PHF21A SAP30 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 SAP30L RBBP4 SAP18 SUDS3 RBBP7 H2BC9 H4C9 RCOR1 H2BC8 H2BC5 H2BC3 ARID4A H2BC1 H2AC20 BRMS1 HMG20B H3C8 MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.4 mRNA Editing: C to U Conversion APOBEC3C APOBEC1 APOBEC2 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.1 Trafficking and processing of endosomal TLR HSP90B1 UNC93B1 CTSV CTSS TLR9 TLR8 CTSL TLR7 CTSK TLR3 LGMN CTSB CNPY3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 80%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway PARP1 PCNA POLD3 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 PARG RFC1 POLB RFC2 RPA2 APEX1 ADPRS POLE4 RPA3 POLE2 PARP2 POLE3 RPA1 FEN1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.1 Toll Like Receptor 2 (TLR2) Cascade RPS6KA2 IKBKB RPS6KA1 ATF1 SIGIRR IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 UBE2V1 RIPK2 IRAK3 NOD1 NOD2 PPP2CA RELA PPP2CB MAPK1 MAPK3 NFKB1 NFKBIA MAP2K3 UBE2N TAB3 TAB2 TAB1 NFKBIB MAPK11 TRAF6 SOCS1 MAP2K1 TNIP2 MAP3K8 IRAK2 ATF2 BTK S100A9 S100A8 MAP2K4 MAPK14 MAP2K7 JUN FOS MAPK9 MAPK8 MAPK10 IRAK1 PELI3 PELI2 PELI1 PPP2R1A LY96 CD14 S100A1 MYD88 DUSP4 BTRC DUSP3 TIRAP PPP2R5D TLR1 VRK3 DUSP6 TLR6 DUSP7 TLR4 MAPK7 PPP2R1B IRAK4 TLR2 SKP1 FBXW11 APP FGB FGA HMGB1 FGG UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB UBC RPS27A AGER S100A12 CD36 ECSIT MAP3K1 S100B NFKB2 SAA1 MEF2A MEF2C RPS6KA3 RPS6KA5 FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 80%2029481 FCGR activation IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 FCGR1A IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 FCGR2A IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G YES1 FGR HCK SYK IGHV3-23 IGLV IGLV2-8 IGKV1-16 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%R-HSA-111465.3 Apoptotic cleavage of cellular proteins DSP PKP1 BCAP31 CASP8 OCLN LMNB1 CASP3 DSG1 PRKCQ CASP7 PRKCD GAS2 MAPT SATB1 PTK2 TJP1 CLSPN GSN BMX STK24 STK26 CDH1 DSG2 PLEC ADD1 SPTAN1 ACIN1 CTNNB1 DSG3 FNTA DBNL APC ROCK1 CASP6 BIRC2 VIM PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 80%167021 PLC-gamma1 signalling NTRK1 PLCG1 NGF CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.3 Cellular response to chemical stress PSMD8 PSMD9 HELZ2 PSMD6 NFE2L2 PSMD7 PSMD4 COX6C PSMD5 GSTA1 PSMD2 HMOX1 LRPPRC PSMD3 PSMD1 SQSTM1 SKP2 TXNIP PSMA5 TACO1 PSMA6 PSMA3 COX6A1 PSMA4 PSMA1 SESN2 PSMA2 AKT2 PSME3 PSME4 PSME1 AKT1 PSME2 COX6B1 PSMD10 PSMB11 PSMD12 PSMD11 COX19 PSMD14 COX16 PSMD13 COX18 ERO1A ATP7A PSMA7 AQP8 NUDT2 MYC BACH1 COX11 PSMB10 TXN2 COX14 GSTP1 PSMA8 SESN1 PSMB6 MUL1 PSMB7 PRDX3 PSMB4 STAP2 CHD9 PSMB5 GCLC PSMB2 NPLOC4 PSMB3 NOX4 PSMB1 PSMF1 NOX5 GCLM SRXN1 PSMB8 MAP1LC3B PSMB9 CYCS ME1 CSNK2A1 SEM1 UBXN7 UFD1 CDKN2A PSMC5 CSNK2A2 ABCC1 ATOX1 PSMC6 COX20 GPX1 PSMC3 G6PD GPX3 PSMC4 GPX6 PSMC1 COX4I1 GPX5 RXRA PSMC2 TALDO1 PTK6 GPX8 NCF1 PGD GPX7 BLVRB NCF2 CSNK2B GPX2 BLVRA HM13 NCF4 TXNRD2 NCOR2 FBXL17 HDAC3 SOD3 NCOR1 TKT CCS TBL1XR1 GSTA3 SIN3A TBL1X NDUFA4 TXNRD1 VCP CYBB CYBA MED1 PPARA GSK3B NQO1 ALB AKT3 CREBBP NOTCH1 P4HB HBA2 EP300 FABP1 CUL3 NCOA2 NLRP3 IDH1 BTRC SKP1 ATF4 TGS1 SLC7A11 PRDX2 PRDX1 UBA52 SMARCD3 CARM1 MT-CO1 PRKCD CUL1 COX7A2L SCO1 UBB SCO2 MT-CO2 MT-CO3 UBC MAFG RPS27A MAFK PRDX6 STAT3 SURF1 NCOA1 SOD2 SOD1 HMOX2 CAT COX7B HBB NCOA6 KEAP1 COX7C TRIM21 COX8A RBX1 COX5B COX5A LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-HSA-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.3 Cyclin A:Cdk2-associated events at S phase entry PSMD8 FZR1 PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 AKT3 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 TFDP1 PSMA1 CCNE2 PSMA2 AKT2 TFDP2 PSME3 PSME1 CDK4 AKT1 CCNE1 PSME2 CABLES1 PSMD10 CDK2 WEE1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYC PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 LIN54 PSMB9 SEM1 LIN52 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 LIN37 PSMC2 LIN9 PTK6 RBL2 CCNH CKS1B MAX E2F4 CDC25B E2F5 CCNA2 CCNA1 UBA52 CUL1 UBB RBBP4 UBC CDK7 RPS27A MNAT1 CDC25A RB1 CDKN1A CDKN1B IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 80%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IKBKB UBE2N IRAK1 UBE2V1 PELI3 PELI2 PELI1 TRAF6 IKBKG CHUK MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.4 Mitotic G1 phase and G1 S transition PSMD8 PSMD9 CCND3 PSMD6 CCND2 PSMD7 CCND1 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 E2F2 E2F3 SKP2 PSMA5 PSMA6 PSMA3 CDK6 PSMA4 TFDP1 PSMA1 CCNE2 PSMA2 AKT2 PSME3 TFDP2 PSME1 CDK4 AKT1 CCNE1 PSME2 CABLES1 PSMD10 CDK2 WEE1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB MYC PPP2R2A PSMB10 PSMB6 LYN PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 LIN54 PSMB9 SEM1 MYBL2 LIN52 CDKN2A PSMC5 PSMC6 PSMC3 RPA1 PSMC4 PSMC1 LIN37 PSMC2 PTK6 LIN9 PPP2R3B CKS1B HDAC1 MAX E2F5 FBXO5 DYRK1A CDC7 DHFR CCNA2 TOP2A CCNA1 MCM10 TK1 DBF4 TYMS E2F6 CDKN2D CDKN2B PRIM2 RRM2 CDKN2C PRIM1 RPA4 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 POLA1 POLA2 CDC25A AKT3 PCNA POLE RPA2 POLE4 RPA3 POLE2 POLE3 PPP2R1A PPP2R1B SKP1 RBL2 RBL1 CCNH E2F4 UBA52 ABL1 CUL1 CCNB1 UBB RBBP4 UBC CDK7 MNAT1 RPS27A CDK1 CDC45 MCM7 MCM8 RB1 CDKN1C CDKN1A MCM3 MCM4 CDKN1B MCM5 MCM6 JAK2 MCM2 MYOGENESIS%REACTOME%R-HSA-525793.2 Myogenesis CDC42 MEF2B CTNNA1 TCF12 MAP2K6 MAPK12 ABL1 MAPK14 CDH4 CDH2 SPAG9 MYOG NEO1 CTNNB1 TCF4 MYF6 TCF3 MYF5 CDON MYOD1 NTN3 CTNNA2 CDH15 MAPK11 BNIP2 MEF2A MEF2D MEF2C NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.2 Neutrophil degranulation AGA METTL7A AOC1 ATP6V0C VCL AGL ERP44 HSPA1B HSPA1A GHDC ATP8A1 ATG7 EPX PYCARD CLEC5A GUSB LRRC7 CLEC4C SLCO4C1 CLEC4D HUWE1 BRI3 HVCN1 HPSE SLC15A4 ATP8B4 CPNE1 CPNE3 DGAT1 KCNAB2 FCGR3B PFKL IMPDH1 ROCK1 IMPDH2 MNDA FOLR3 CSNK2B PLAUR B2M SLC11A1 CHIT1 DSP MGST1 PLD1 CKAP4 UBR4 PTPRN2 SIGLEC14 STK11IP DSG1 GDI2 GLIPR1 MANBA NME2 GAA CEACAM3 CEACAM1 CEACAM6 SLC44A2 ALDOC LPCAT1 CEACAM8 ALDOA GYG1 DNASE1L1 LILRA3 BST1 CXCR1 CXCR2 LILRB2 LILRB3 SIRPA CD300A AGPAT2 C5AR1 DPP7 HSPA6 DNAJC13 MAN2B1 CRISP3 SLC2A3 CXCL1 SLC2A5 HEBP2 NAPRT FRK CMTM6 CD14 TRPM2 CEP290 TLR2 HSP90AA1 APAF1 TUBB DYNLL1 VNN1 PRKCD DYNC1LI1 FPR1 CNN2 FPR2 GNS IQGAP1 IQGAP2 ANXA2 DYNC1H1 MIF HMOX2 TUBB4B JUP ARHGAP9 PPIA PSMD6 PSMD7 GMFG PSMD2 PSMD3 C3AR1 PSMD1 PGLYRP1 CAB39 MCEMP1 GSDMD LTA4H PSMA5 TOLLIP FUCA1 FUCA2 PSMA2 PSMD12 SIGLEC9 PSMD11 PSMD14 OLR1 ALOX5 PSMD13 PAFAH1B2 GSTP1 PTAFR PSMB7 STK10 PSMB1 LAMTOR2 YPEL5 LAMTOR1 NFKB1 LAMTOR3 SIGLEC5 PSMC3 APEH TOM1 CYFIP1 PSMC2 IST1 ATP11B STING1 ATP11A SNAP23 ACLY SLC27A2 ARL8A FTL ARPC5 TXNDC5 STBD1 NRAS NIT2 SNAP25 ITGAM CYBB CYBA ITGB2 ITGAL ALAD ITGAX ACTR2 ACP3 SNAP29 PGM1 RAB7A RNASET2 CAPN1 PRSS2 TNFRSF1B TMBIM1 BPI ADAM10 CANT1 ADAM8 NCKAP1L TSPAN14 PSEN1 NCSTN ELANE LGALS3 PKP1 ANPEP CTSS DSC1 MMP25 LCN2 S100A9 C6orf120 S100A8 SLPI DSN1 LTF S100A7 CRISPLD2 TIMP2 CTSG TMEM63A MMTAG2 SYNGR1 CTSD FAF2 CTSB RAB27A PTPRC NBEAL2 MMP8 PPBP MMP9 BST2 ITGAV SPTAN1 RHOG RHOF CD44 ACTR1B CAMP PRCP FCER1G RAP2C RAP2B CD177 GCA ACTR10 SRP14 PLAU ENPP4 RAB9B IRAG2 PPIE PRTN3 ADGRG3 MGAM GGH ADA2 IGF2R ARHGAP45 MS4A3 TNFAIP6 ADGRE5 CD36 ADGRE3 ATP6AP2 CAP1 CAT CHI3L1 RETN CAND1 GALNS PTX3 CDA FRMPD3 PRSS3 ARMC8 CFP PLAC8 DIAPH1 TCN1 TYROBP GPI PYGB EEF1A1 AHSG PLEKHO2 GRN GSN RAB3A TMEM179B RAB3D MOSPD2 RAB44 LAMP1 LAMP2 EEF2 STOM KCMF1 ILF2 RAB31 RAB37 RAB5B RAB5C RAB6A AP1M1 RAB4B TRAPPC1 FCAR CR1 PKM DNAJC5 FGL2 TTR RAB24 CPPED1 RAB10 RAB18 CALML5 FTH1 TBC1D10C HLA-H HLA-B HLA-C HLA-A FGR PECAM1 MLEC VAT1 ORM1 ORM2 CSTB CST3 LAIR1 PTGES2 SVIP MAPK14 QPCT FCN1 P2RX1 COTL1 PTPN6 COPB1 KPNB1 IDH1 SELL C3 CFD HK3 HGSNAT PDXK HSP90AB1 CLEC12A HMGB1 TMEM30A RNASE3 SCAMP1 RNASE2 FLG2 PADI2 NFASC CYB5R3 AZU1 LYZ HRNR S100A12 PIGR ACAA1 KRT1 HBB ARG1 PGAM1 TMC6 SERPINB10 SERPINB12 LRG1 HP TICAM2 OLFM4 DNAJC3 DOCK2 DEFA4 PTPRB NDUFC2 MAPK1 FCGR2A VPS35L DERA CHRNB4 PGM2 COMMD9 RAC1 XRCC6 VCP XRCC5 SURF4 NPC2 PRG2 PRG3 CYSTM1 SDCBP CTSZ PTPRJ RHOA CTSH QSOX1 CD33 CTSC HEXB CD53 DBNL MME COMMD3 ANO6 GM2A CD47 CD63 ARSA PGRMC1 CREG1 CD59 CD58 CD55 ASAH1 GPR84 CD68 ALDH3B1 MPO NEU1 OSTF1 FABP5 ORMDL3 PSAP CD93 ATAD3B OSCAR DOK3 HSPA8 ARSB CTSA TARM1 VAPA DDX3X GLB1 SIRPB1 DEGS1 DYNLT1 CCT2 MAGT1 MVP DEFA1B PDAP1 S100P ABCA13 GOLGA7 NHLRC3 UNC13D BIN2 A1BG CRACR2A DDOST PRDX4 S100A11 CCT8 PA2G4 PRDX6 AMPD3 APRT CDK13 SERPINA3 PNP B4GALT1 SERPINA1 TCIRG1 AP2A2 RAP1B ATP6V1D SERPINB3 RAP1A SERPINB1 ATP6V0A1 NFAM1 SERPINB6 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.1 Establishment of Sister Chromatid Cohesion SMC1A ESCO1 CDCA5 RAD21 PDS5B ESCO2 PDS5A WAPL STAG1 STAG2 SMC3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.2 RNA Polymerase III Transcription Initiation POLR3GL TBP POLR1C POLR1D GTF3C1 GTF3C2 POLR2E POLR3A GTF3C3 POLR2F POLR3B GTF3C4 POLR3C GTF3C5 POLR2H POLR3D GTF3C6 POLR3E SNAPC5 SNAPC1 POLR2K POLR3F SNAPC2 POLR2L POLR3G SNAPC3 POLR3H SNAPC4 POLR3K ZNF143 BRF2 BRF1 GTF3A BDP1 POU2F1 CRCP NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 80%927802 Nonsense-Mediated Decay (NMD) RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L PPP2CA RPS4Y1 RPS15A PPP2R2A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UPF2 EIF4A3 CASC3 MAGOH SMG1 NCBP1 SMG9 NCBP2 SMG7 SMG8 SMG5 SMG6 UPF1 PNRC2 UPF3A RBM8A UPF3B MAGOHB RNPS1 PPP2R1A ETF1 UBA52 DCP1A GSPT2 GSPT1 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.4 Chemokine receptors bind chemokines XCL1 CX3CR1 CCL13 CCL19 CXCR5 CXCR6 CCL22 CCL7 CCL20 CXCR3 CCL1 CCL17 CCL16 CCR10 CCL25 XCR1 CCL21 CXCL11 CXCL8 ACKR4 ACKR3 ACKR2 CXCL1 CCL28 CCL27 CXCL2 CXCL10 CXCL12 PPBP CCL5 CCL4 CCL3 CCL2 CCL3L3 CXCR4 CCR1 PF4 CCR6 CXCR1 CXCR2 CCR5 CCR2 CXCL6 CXCL9 CXCL13 CXCL3 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 XCL2 CCL11 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.2 FasL CD95L signaling FAS FASLG CASP8 CASP10 FADD NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP1M2 PACS1 AP1M1 LCK CD28 CD4 CD8B AP2S1 AP1G1 ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 AP1B1 ARF1 HLA-A AP1S2 AP1S1 B2M AP1S3 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 80%8866654 E3 ubiquitin ligases ubiquitinate target proteins LEO1 PRKDC PAF1 UBE2J2 UBE2E1 PCNA RNF152 SHPRH PEX2 RNF40 UBE2L3 RNF144A SELENOS WAC DERL1 TMEM129 HLTF UBE2B PEX10 BCL10 PEX12 PEX14 UBE2A RNF181 RRAGA UBE2N WDR61 UBE2D3 UBE2V2 UBA52 VCP H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBB UBC RAD18 H2BC9 RPS27A H2BC8 H2BC5 H2BC3 H2BC1 HLA-B RNF20 HLA-A CDC73 UBE2D2 CTR9 UBE2D1 RTF1 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 80%8941413 Events associated with phagocytolytic activity of PMN cells MPO LPO GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.3 GABA B receptor activation ADCY3 GNGT2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAL ADCY9 KCNJ2 KCNJ3 GNG10 KCNJ4 GABBR2 KCNJ5 GABBR1 KCNJ10 KCNJ12 GNG12 KCNJ9 GNG11 GNG13 KCNJ15 GNB2 KCNJ16 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY4 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-HSA-5685942.1 HDR through Homologous Recombination (HRR) RAD51B RAD51C RAD1 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 BLM RFC1 RFC2 RPA2 MRE11 WRN POLE4 RPA3 MUS81 POLE2 EME1 POLE3 EME2 POLH GEN1 SLX1B SPIDR SLX4 XRCC3 SEM1 BRCA2 RAD9B RAD51AP1 RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51D RAD50 RAD51 UBA52 DNA2 RTEL1 HUS1 UBB UBC RHNO1 RPS27A ATRIP RAD17 CHEK1 ATR BRCA1 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.1 LXRs regulate gene expression linked to cholesterol transport and efflux NCOR1 TNRC6B TBL1XR1 KDM4A GPS2 TBL1X APOC2 MOV10 RXRB ABCG1 APOD EP300 ABCA1 NR1H2 APOC4 NR1H3 APOC1 AGO3 AGO4 AGO1 AGO2 NCOA1 KDM3A KDM1B ABCG8 ABCG5 ARL4C EEPD1 CETP KDM1A RXRA TNRC6C APOE NCOR2 TNRC6A HDAC3 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.2 Nucleotide biosynthesis GMPS ADSL CAD PAICS PFAS DHODH ATIC IMPDH1 PPAT IMPDH2 ADSS1 ADSS2 UMPS GART FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%190371 FGFR3b ligand binding and activation FGF1 FGF18 FGF9 FGF20 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 80%5683678 Defective ABCA3 causes SMDP3 ABCA3 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 80%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.1 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP4A CHMP6 CHMP7 PIK3C3 PIK3R4 BECN1 MAP1LC3B CHMP2B CHMP4C CHMP2A UVRAG CHMP4B CHMP3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME DATABASE ID RELEASE 80%5696399 Global Genome Nucleotide Excision Repair (GG-NER) SUMO3 YY1 SUMO2 GPS1 PARP1 ACTB PIAS1 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 LIG1 RFC1 XPC RFC2 RPA2 XRCC1 LIG3 POLE4 CETN2 RPA3 POLE2 POLE3 PIAS3 UBE2N UBE2I RPA1 SUMO1 NFRKB ACTR5 ACTL6A CCNH USP45 ACTR8 INO80C INO80B INO80E INO80D UBE2V2 COPS7B COPS4 COPS7A TFPT MCRS1 UBA52 INO80 COPS2 RUVBL1 COPS3 COPS6 COPS5 COPS8 RAD23A RAD23B UBB UBC CDK7 RPS27A MNAT1 XPA PARP2 GTF2H1 CHD1L GTF2H2 GTF2H3 GTF2H4 GTF2H5 DDB2 CUL4A DDB1 ERCC3 ERCC4 ERCC1 ERCC2 ERCC5 CUL4B RBX1 RNF111 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.2 Defective DHDDS causes RP59 NUS1 DHDDS GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.3 Generation of second messenger molecules HLA-DPB1 PAK1 CD101 LCK HLA-DQA2 VASP LAT HLA-DQA1 PAK3 PAK2 HLA-DRB5 HLA-DRB4 TRBC1 PLCG1 HLA-DQB2 HLA-DQB1 GRAP2 TRBV12-3 NCK1 TRBV7-9 PLCG2 TRAV19 HLA-DRB3 HLA-DRB1 HLA-DRA LCP2 ZAP70 CD3G TRAC CD3E CD3D FYB1 EVL CD4 TRAV8-4 ITK HLA-DPA1 ENAH WAS TRAV29DV5 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 80%5632928 Defective Mismatch Repair Associated With MSH2 MSH3 MSH6 MSH2 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.2 Sensory processing of sound TWF1 KCNMB1 CLIC5 RIPOR2 CIB2 PJVK ESPN SPTBN1 EPS8 CACNA1D PLS1 TPRN TMC1 ATP2B1 MYO7A TMC2 MYO3B GSN MYO3A KCNQ4 CAPZA1 FSCN2 TWF2 CAPZA2 PCDH15 RAB3A USH1C ESPNL EPB41L1 EPB41L3 OTOG SPTAN1 CACNB2 CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 SNAP25 STX1A DNAJC5 PCLO BSN CACNA2D2 SYP CABP2 CABP1 LRRC52 OTOF SLC17A8 CASK MSN CHRNA9 CHRNA10 KCNN2 MYH9 SYN1 VAMP2 EZR CAPZB RDX MYO1C KCNMA1 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 80%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 80%68962 Activation of the pre-replicative complex CDC7 MCM10 DBF4 PRIM2 PRIM1 RPA4 GMNN ORC5 POLE ORC4 ORC6 CDK2 ORC1 ORC3 ORC2 CDT1 RPA2 CDC6 POLE4 RPA3 POLE2 POLE3 POLA1 POLA2 RPA1 CDC45 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.2 Vasopressin-like receptors AVP OXTR AVPR1B AVPR2 OXT AVPR1A TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.3 TICAM1, RIP1-mediated IKK complex recruitment IKBKB UBE2D3 RPS27A TRAF6 IKBKG RIPK1 CHUK UBA52 RIPK3 UBE2N TICAM1 UBE2V1 TLR3 UBE2D2 UBB UBE2D1 BIRC2 BIRC3 UBC APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 80%174154 APC C:Cdc20 mediated degradation of Securin ANAPC11 PSMD8 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTTG1 UBA52 UBB UBC RPS27A CDC20 UBE2D1 ANAPC15 ANAPC16 ANAPC10 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 80%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNA4 CHRNA6 CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 80%2514853 Condensation of Prometaphase Chromosomes NCAPG CSNK2A1 NCAPD2 CDK1 SMC4 CSNK2A2 NCAPH SMC2 CCNB2 CCNB1 CSNK2B NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.2 NoRC negatively regulates rRNA expression HDAC2 H3C15 CCNH HDAC1 SIN3A H2AX ARID4B H3-3B H2AB1 TTF1 H2AC19 SIN3B SAP130 H2AC14 UBTF H2BC12L DNMT3B SAP30BP H2BC21 TBP SAP30 H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 DNMT1 H2AJ BAZ2A H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E SAP30L POLR2F TAF1A SAP18 POLR2H SUDS3 H2AZ1 MBD2 POLR2K H2BC9 CDK7 POLR2L MNAT1 H2AZ2 GTF2H1 H4C9 H2BC8 GTF2H2 GTF2H3 GTF2H4 H2BC5 GTF2H5 H2BC3 SMARCA5 H2BC1 ERCC3 H2AC20 ERCC2 H3C8 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 80%392154 Nitric oxide stimulates guanylate cyclase PDE5A PDE9A PDE1B PDE1A ITPR1 GUCY1B2 PDE11A GUCY1B1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 NOS2 NOS3 PDE2A PRKG2 NOS1 GUCY1A2 GUCY1A1 IRAG1 PDE10A KCNMA1 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.2 Ephrin signaling MYL12A EPHB3 PAK1 FYN RAC1 PAK3 PAK2 GIT1 NCK2 EPHB6 ARHGEF7 EPHB2 EFNB2 EPHB1 SDCBP EFNB1 EPHB4 EFNB3 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 80%163754 Insulin effects increased synthesis of Xylulose-5-Phosphate TKT TALDO1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.2 Maturation of protein 3a ST3GAL4 ST6GALNAC2 GALNT1 ST3GAL1 ST6GALNAC3 ST6GALNAC4 ST3GAL2 ST3GAL3 ST6GAL1 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 80%6802948 Signaling by high-kinase activity BRAF mutants CNKSR1 FGB FGA TLN1 VWF RAF1 VCL FGG YWHAB SRC NRAS HRAS MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 MAP2K2 KSR1 FN1 KSR2 CNKSR2 APBB1IP DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 80%73893 DNA Damage Bypass UBE2L6 RCHY1 REV1 MAD2L2 REV3L POLI UBA52 VCP TRIM25 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 UBB RFC1 WDR48 UBE2B RFC2 USP1 RPA2 UBC DTL RAD18 POLE4 UBA7 RPS27A RPA3 POLE2 POLE3 USP10 POLH PCLAF USP43 SPRTN NPLOC4 CUL4A DDB1 ISG15 UFD1 CUL4B RPA1 RBX1 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 80%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 NANOG POU5F1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 80%8951671 RUNX3 regulates YAP1-mediated transcription YAP1 RUNX3 TEAD1 TEAD4 CCN2 TEAD2 WWTR1 TEAD3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.1 Formation of Incision Complex in GG-NER CCNH SUMO3 USP45 SUMO2 UBE2V2 PARP1 UBA52 RAD23A PIAS1 RAD23B UBB XPC RPA2 UBC CDK7 CETN2 RPS27A RPA3 MNAT1 XPA PARP2 GTF2H1 CHD1L PIAS3 GTF2H2 GTF2H3 GTF2H4 GTF2H5 DDB2 CUL4A DDB1 ERCC3 ERCC4 ERCC1 ERCC2 UBE2N ERCC5 CUL4B UBE2I RPA1 SUMO1 RBX1 RNF111 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 80%69002 DNA Replication Pre-Initiation ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 PSMA4 H3C15 PSMA1 PSMA2 PSME3 UBE2S PSME1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 KPNA1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 RPA1 PSMC4 PSMC1 PSMC2 H3-3B CDC7 MCM10 DBF4 PRIM2 PRIM1 RPA4 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 POLA1 POLA2 POLE RPA2 POLE4 RPA3 POLE2 POLE3 KPNB1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L UBA52 H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB UBC H2AZ1 H2BC9 RPS27A H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 KPNA6 H2AC20 CDC45 MCM7 MCM8 H3C8 MCM3 UBE2D1 ANAPC15 MCM4 MCM5 ANAPC16 MCM6 ANAPC10 MCM2 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.1 Regulation by c-FLIP TNFSF10 TNFRSF10B FAS TNFRSF10A TRADD FASLG TRAF2 CASP8 RIPK1 FADD DRUG ADME%REACTOME DATABASE ID RELEASE 80%9748784 Drug ADME UGT3A2 GSTM1 TPMT UGT3A1 SULT1A4 ABCC5 GMPS SULT1A3 GGT5 NME1 GLYATL3 GUK1 GLYATL2 GSTA1 GGT7 GLYATL1 GGT6 CYP2C9 CYP2C8 SLC22A7 SLCO1B1 ACSM2A ACSM2B UGT1A3 UGT2A3 UGT2A2 SLCO1B3 UGT2A1 SULT1C4 ABCC3 UGT1A1 UGT2B4 UGT2B7 PON3 NUDT15 ADH1A PON1 UGT2B28 CYP3A4 NT5C2 SULT1E1 UGT1A5 UGT1A9 UGT1A8 UGT1A7 UGT1A6 SLC16A1 GSTP1 GGT3P SLC28A2 SLC29A1 SLC29A2 SLC28A3 SLC22A3 ABCC1 ABCB1 ABCG2 IMPDH1 IMPDH2 RAC1 VAV1 NME2 VAV2 BSG XDH BCHE ALB VAV3 SLC22A2 SLC22A1 ACY1 PCK1 UGT1A4 NAT1 ADAL NAT2 HPRT1 UGT1A10 ACSM5 GSTA2 ACSM4 CYP2D6 GGT1 SULT2A1 UGT2B10 UGT2B11 UGT2B15 ABCC2 UGT2B17 CYP2E1 CES2 CES1 GSTT1 GLYAT CYP2C19 SULT1A1 ABCC4 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.2 Toxicity of tetanus toxin (tetX) VAMP2 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 80%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 80%5083630 Defective LFNG causes SCDO3 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 80%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins ANAPC11 PSMD8 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NEK2 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTTG1 CCNA2 CCNA1 UBA52 CCNB1 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 PLK1 CDK1 UBE2D1 ANAPC15 ANAPC16 ANAPC10 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.2 Manipulation of host energy metabolism PGK1 ENO1 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 80%156580 Phase II - Conjugation of compounds UGT3A2 GSTM1 TPMT UGT3A1 SULT1A4 SULT1A3 GGT5 GLYATL3 SLC35B3 GLYATL2 GSTA1 SLC35B2 GGT7 GLYATL1 GGT6 SLC35D1 ACSM2A ACSM2B UGT1A3 UGT2A3 UGT2A2 UGT2A1 SULT1C4 UGT1A1 UGT2B4 UGT2B7 UGT2B28 SULT1E1 UGT1A5 UGT1A9 UGT1A8 UGT1A7 UGT1A6 GSTP1 GGT3P N6AMT1 ACSM1 HPGDS GCLC AS3MT ABHD10 CHAC2 CHAC1 GCLM GSTK1 MAT1A TPST2 TPST1 SULT6B1 NNMT MGST3 MGST2 GSTT2 PAPSS1 ESD GSTT2B SULT1A2 GSTM4 GSTM3 GSTM2 GGCT SULT1B1 CYP1A2 GSTM5 PODXL2 GSTA3 OPLAH SULT1C2 SULT4A1 GSTO2 AKR1A1 MGST1 ABHD14B UGDH AHCY MAT2B PAPSS2 UGP2 MAT2A BPNT2 BPNT1 GSTZ1 GSTA5 GSTA4 TRMT112 MTRR MTR SLC26A2 SLC26A1 GSS GSTO1 UGT1A4 NAT1 NAT2 COMT UGT1A10 ACSM5 GSTA2 ACSM4 GGT1 SULT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 GSTT1 GLYAT SULT1A1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 80%419037 NCAM1 interactions NCAM1 COL9A1 COL9A3 NRTN COL9A2 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 CACNA1D COL4A3 CACNA1C NCAN CACNA1H CACNA1G COL6A3 CACNA1I ST8SIA4 COL4A5 CACNA1S COL6A6 COL6A5 PRNP PSPN ST8SIA2 ARTN CACNB1 GDNF CNTN2 AGRN GFRA1 CACNB2 CACNB3 CACNB4 GFRA2 GFRA4 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.2 Hh mutants are degraded by ERAD PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SHH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 VCP SEL1L DERL2 ERLEC1 OS9 SYVN1 UBB UBC RPS27A PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 80%9609507 Protein localization HMOX1 STX5 COX19 PRNP SLC25A4 SLC25A6 GSTK1 PIPOX GNPAT SLC27A2 EMD AGPS PECR ZFAND6 VDAC1 TOMM20 TOMM22 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 NUDT19 MPV17 PHYH CMC4 CMC2 PAM16 ECH1 BCS1L ACOT2 COX17 PEX11B TIMM50 ATP5MC1 BAG6 PITRM1 GRPEL1 LDHD GRPEL2 HACL1 HAO1 CYC1 HAO2 DNAJC19 COA4 TAFAZZIN FIS1 EPHX2 CHCHD10 TYSND1 TIMM44 TIMM10B CS COQ2 DAO PXMP2 PXMP4 ACO2 ABCD2 IDE HSCB HMGCL CROT SERP1 SEC61G TIMM17A SEC61B TIMM17B GET1 GET3 COA6 GET4 CAMLG NOS2 TIMM23 TIMM22 PAOX TIMM21 PEX1 PEX2 PEX7 SLC25A17 LONP2 PEX3 ACOX1 PEX6 ACOX3 SLC25A12 AGXT FXN USP9X PEX10 SLC25A13 PEX12 NDUFB8 PEX14 TOMM40 TIMM9 TIMM13 TIMM10 DDO ATP5F1A HSPD1 ATP5F1B TIMM8B PMPCB ATAD1 PEX16 PMPCA IDH1 UBL4A TIMM8A PEX19 MTX2 IDH3G SGTA GFER GDAP1 DHRS4 NUDT7 TOMM7 CRAT TOMM5 TOMM6 OTC VAPA APP UBE2D3 SAMM50 MTX1 UBA52 STX1A TOMM70 EHHADH DECR2 ACOT4 UBB OTOF UBC RPS27A HSPA9 ACOT8 SCP2 BAAT AMACR ACOX2 HSD17B4 ACAA1 ABCD1 CAT VAMP2 UBE2D2 UBE2D1 ACBD5 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 80%179409 APC-Cdc20 mediated degradation of Nek2A ANAPC11 CDC23 CDC26 CDC27 UBA52 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 UBB ANAPC5 ANAPC1 ANAPC2 UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 NEK2 ANAPC15 UBE2D1 ANAPC16 ANAPC10 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.1 Signaling by ERBB2 KD Mutants ERBB2 ERBIN SHC1 EGF GAB1 PIK3R1 EGFR NRAS NRG1 PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 BTC NRG3 NRG4 NRG2 HBEGF EREG TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.3 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 TICAM2 CHUK TLR9 MAPKAPK3 MAPKAPK2 TLR7 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A LY96 CD14 DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N TLR4 MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 TICAM1 CUL1 ELK1 CREB1 UBB MAP2K1 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER S100A12 ECSIT MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 80%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 IRS-MEDIATED SIGNALLING%REACTOME%R-HSA-112399.3 IRS-mediated signalling IRS1 TRIB3 FLT3 PIK3CB PDPK1 PIK3R4 FLT3LG GAB1 GAB2 PIK3R1 TLR9 KLB NRAS PIK3CA SOS1 AKT2 HRAS FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 IRS2 FGF19 PIK3C3 PIK3R2 FGFR4 THEM4 FGF16 FGF7 FGF18 PDE3B PTPN11 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 80%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors YY1 ERBB2 CGA TGFA EGFR TFAP2A ESR1 TFAP2B TFAP2C KIT VEGFA CGB8 ATAD2 UCH PROTEINASES%REACTOME%R-HSA-5689603.2 UCH proteinases PSMD8 PSMD9 YY1 PSMD6 PSMD7 PSMD4 PSMD5 USP15 PSMD2 PSMD3 NEDD8 PSMD1 H2AW H2AC17 PSMA5 H2AC12 PSMA6 H2AC1 PSMA3 ACTB UCHL5 PSMA4 PSMA1 SMAD7 PSMA2 H2AC21 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 UCHL3 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 KDM1B PSMB8 PSMB9 SEM1 TGFB1 PSMC5 TGFBR1 PSMC6 TGFBR2 PSMC3 PSMC4 PSMC1 PSMC2 BARD1 UCHL1 SENP8 HCFC1 NFRKB FOXK2 ACTR5 FOXK1 ACTL6A MBD5 MBD6 ACTR8 ADRM1 INO80C ASXL1 INO80B ASXL2 H2AC19 INO80E INO80D H2AC14 BAP1 TFPT MCRS1 UBA52 INO80 RUVBL1 H2AC8 H2AC6 H2AC7 OGT UBB UBC RPS27A H2AC20 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 80%140875 Common Pathway of Fibrin Clot Formation CD177 FGB FGA F10 SERPIND1 F2R FGG F2 F5 PROCR F8 PROC SERPINE2 SERPINC1 PROS1 PRTN3 F13A1 F13B PF4 SERPINA5 THBD PF4V1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.3 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) SEC11A SEC11C GIP GATA4 ISL1 PAX6 PCSK1 GPR119 DPP4 SPCS3 SPCS2 SPCS1 FFAR1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 80%844615 The AIM2 inflammasome AIM2 CASP1 PYCARD DEFECTIVE FMO3 CAUSES TMAU%REACTOME%R-HSA-5579019.2 Defective FMO3 causes TMAU FMO3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 80%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPX1 GPX4 ALOX15 ALOX15B PTGS2 GPX2 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 80%9664422 FCGR3A-mediated phagocytosis IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DOCK1 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MAPK1 IGKV3-15 IGKV3-11 MAPK3 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 NCKAP1 IGHV4-34 CYFIP1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 BRK1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 ARPC4 ARPC5 V1-3 IGKV3D-20 V5-6 FYN RAC1 ARPC2 ARPC3 IGLV3-19 VAV1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 CRK IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 NCK1 IGHV3-53 ACTR3 VAV2 V4-2 IGLC7 ACTR2 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G YES1 MYH9 NCKAP1L WASF3 WASF1 WASF2 MYO1C ELMO1 FGR BAIAP2 BTK ABI2 ABI1 HCK ACTB PTK2 VAV3 WASL SYK MYO5A MYH2 MYO10 WAS CYFIP2 WIPF1 WIPF2 WIPF3 MYO9B ABL1 ACTG1 ELMO2 NCKIPSD ARPC1B ARPC1A IGHV3-23 IGLV IGLV2-8 IGKV1-16 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 80%435368 Zinc efflux and compartmentalization by the SLC30 family SLC30A5 SLC30A1 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 DEFECTIVE HEXA CAUSES GM2G1%REACTOME%R-HSA-3656234.1 Defective HEXA causes GM2G1 HEXA TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.3 trans-Golgi Network Vesicle Budding SH3GL2 STX4 HGS AP3B1 HSPA8 RAB5C TFRC SNAP23 APP AP1M2 AP1M1 FTL CLTC CLTA AP4E1 CLINT1 AP4M1 TXNDC5 AP1G2 TGOLN2 AP1G1 AP3S1 SH3D19 TPD52 GAK DNAJC6 DNASE2 CPD NAPA BLOC1S4 BLOC1S6 SNX2 ARF1 OCRL BLOC1S1 PICALM BLOC1S3 CLVS2 AP4S1 SNX9 SNX5 CLVS1 TBC1D8B SNAPIN SORT1 CTSZ M6PR DTNBP1 GNS HIP1R IGF2R PUM1 TPD52L1 AP4B1 NECAP1 GOLGB1 YIPF6 ACBD3 GBF1 VAMP7 FTH1 DNM2 VAMP2 ARRB1 AP1B1 PIK3C2A AP1S2 CLTB AP1S1 CHMP2A AP1S3 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.2 Defective ALG11 causes CDG-1p ALG11 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.2 Phase 1 - inactivation of fast Na+ channels KCND1 KCND2 KCND3 KCNIP1 KCNIP2 KCNIP3 KCNIP4 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702600 midostaurin-resistant FLT3 mutants FLT3 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 80%202131 Metabolism of nitric oxide: NOS3 activation and regulation LYPLA1 NOSIP ZDHHC21 DNM2 NOS3 CYGB DDAH1 SPR DDAH2 HSP90AA1 NOSTRIN AKT1 CAV1 WASL CALM1 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 80%512988 Interleukin-3, Interleukin-5 and GM-CSF signaling CSF2RB CSF2RA PIK3CD CRKL PIK3CB FYN SHC1 INPP5D PIK3R3 GAB2 INPPL1 PIK3R1 VAV1 CBL HCK PIK3CA CRK SOS1 SYK RAPGEF1 YWHAZ JAK3 CSF2 JAK1 YES1 PTPN6 IL5RA PIK3R2 LYN PRKACA IL2RG BLNK IL3RA STAT5A IL2 TEC STAT5B IL3 IL2RA PTPN11 IL5 IL2RB JAK2 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 80%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBAP1 RPS27A VPS28 UBA52 TSG101 MVB12B MVB12A VPS37C VPS37D NMT2 VPS37A VPS37B UBB UBC TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.3 TNFR2 non-canonical NF-kB pathway PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 CHUK PSMA5 PSMA6 PSMA3 EDARADD PSMA4 PSMA1 TNFRSF11B PSMA2 PSME3 TNFRSF11A PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 EDAR PSMC3 PSMC4 PSMC1 TNFRSF8 PSMC2 TNFRSF4 MAP3K14 TNFRSF17 TNFRSF14 TNFRSF9 TNFSF13B CD27 TNFRSF13B TNFRSF13C TNFRSF18 EDA2R TNFRSF1B UBA3 TNFRSF25 UBE2M TNFRSF12A TNFRSF6B TNFSF11 CD70 TNF CD40LG TNFSF18 TNFSF14 TNFSF15 TNFSF12 TNFSF13 LTBR BTRC SKP1 FBXW11 LTA LTB EDA RELB UBA52 CUL1 TRAF2 UBB TRAF3 UBC RPS27A TNFSF6 TNFSF4 TNFSF9 TNFSF8 NFKB2 TNFRSF1A BIRC2 BIRC3 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 80%5685938 HDR through Single Strand Annealing (SSA) RAD50 RAD51 RAD1 DNA2 ABL1 RFC5 RFC3 HUS1 RFC4 BLM RFC2 RPA2 MRE11 RHNO1 WRN RPA3 ATRIP RAD17 ATR ERCC4 ERCC1 RAD9B RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 RAD52 TOPBP1 RMI2 RMI1 TOP3A BRCA1 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.2 Defective DPM1 causes CDG-1e DPM2 DPM3 DPM1 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 80%2470946 Cohesin Loading onto Chromatin SMC1A RAD21 PDS5B NIPBL PDS5A MAU2 WAPL STAG1 STAG2 SMC3 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.3 Diseases associated with glycosylation precursor biosynthesis DPM2 DPM3 GNE NUS1 DHDDS GFPT1 GALE GALT SRD5A3 MPI PMM2 DOLK DPM1 PGM1 GALK1 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 80%9679514 SARS-CoV-1 Genome Replication and Transcription VHL DDX5 ZCRB1 RB1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.1 Downstream signaling of activated FGFR2 FGF22 FGF10 FGF16 FGF7 GAB1 FGF18 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 80%9036866 Expression and Processing of Neurotrophins FURIN NGF PCSK6 PCSK5 KERATINIZATION%REACTOME DATABASE ID RELEASE 80%6805567 Keratinization TGM1 TGM5 SPINK6 SPINK5 SPINK9 KRTAP23-1 LELP1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP12-4 TCHH KRTAP10-1 CELA2A KRTAP21-2 KRTAP21-3 DSP KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP21-1 LCE1A LCE1B DSG1 PKP4 PRSS8 KRTAP17-1 LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A KRTAP4-11 ST14 KRTAP26-1 LCE5A KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP15-1 LCE6A IVL LCE2D LCE3C LCE3D LCE3A LCE3B LCE3E LCE4A KRTAP3-3 KRTAP3-2 KRTAP3-1 RPTN PI3 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 KRT4 KRT3 KRT2 KRT1 KRT8 JUP KRT7 KRT5 KRT9 KRTAP20-1 KRTAP20-2 SPRR2E SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KLK5 KLK8 KRT33B KRT33A SPRR2A SPRR2B SPRR2D CDSN SPRR1A SPRR1B KRT24 KRT23 KRT20 KRT28 KRT27 KRT26 KRT25 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 SPRR3 CSTA KRT13 KRT12 LIPJ KRT10 KRT19 KRT18 KRT17 LIPN KRT16 LIPM KRT15 LIPK KRT14 KRTAP24-1 KRT6C KRT6B KRT6A KRT71 FLG KRTAP13-2 KRTAP13-1 KRTAP27-1 KRTAP13-4 KRTAP5-10 KRTAP13-3 KRTAP5-11 KRT79 KAZN KRTAP16-1 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRT40 CAPNS1 CASP14 DSG2 CAPN1 KRTAP22-1 KRTAP11-1 PPL KRTAP25-1 PCSK6 KRTAP2-4 KRTAP2-3 KRT82 KRT81 KRTAP2-2 KRT80 KRT86 KRTAP2-1 KRT85 KRT84 KRT83 PKP2 PKP1 PKP3 DSC1 DSC2 DSC3 KRTAP4-4 KRTAP4-3 KRTAP4-2 KRTAP4-1 KRTAP4-9 KRTAP4-8 KRTAP4-7 KRTAP4-6 KRTAP4-5 DSG3 DSG4 KRTAP29-1 KRTAP6-2 FURIN KRTAP6-1 KRTAP6-3 LORICRIN EVPL KRTAP8-1 PERP KLK13 KLK14 KLK12 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.3 HDMs demethylate histones KDM5A KDM4B KDM5B PHF2 KDM5C KDM4A KDM5D KDM3B PHF8 UTY KDM6B KDM2A KDM4D KDM2B ARID5B JMJD6 RIOX2 H3C15 H4C9 KDM3A KDM1B KDM6A KDM7A KDM1A KDM4C H3C8 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%R-HSA-174362.2 Transport and synthesis of PAPS SLC35B3 PAPSS1 SLC35B2 PAPSS2 SLC26A2 SLC26A1 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.2 Signaling by NOTCH1 HEY1 HEY2 HES5 ITCH CREBBP HEYL NOTCH1 MAML2 HDAC10 MAML1 HDAC11 HDAC2 DNER TLE4 RBPJ TLE2 HDAC8 TLE1 KAT2B KAT2A DTX1 DTX2 SNW1 EP300 DTX4 HDAC9 HES1 DLK1 MAML3 MAMLD1 HDAC6 HDAC7 MYC HDAC4 CNTN1 JAG2 NBEA MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SKP1 HDAC5 CCNC NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X HIF1A UBA52 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 ADAM17 ARRB1 ARRB2 PSEN1 RBX1 JAG1 NCSTN NUMB ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.1 ALKBH2 mediated reversal of alkylation damage ALKBH2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.6 Triglyceride biosynthesis GPAT2 DGAT2 DGAT1 GPAM GK3P MOGAT3 MOGAT2 MOGAT1 GK2 LPIN1 LPIN2 AGMO LPIN3 GK PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 80%9674428 PDGFR mutants bind TKIs PDGFRA RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%8980692 RHOA GTPase cycle ARHGAP28 CIT ARHGAP24 ARHGAP23 DIAPH1 PKN3 ARHGAP31 ARHGAP30 SOWAHC ARHGEF10L DOCK2 MCF2L STX5 FLOT1 FARP1 ARHGEF11 ARHGEF10 DEF6 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF18 AAAS ARAP1 PKN2 PKN1 ARHGAP10 FAM13A STK10 SLK STOM TEX2 OBSCN TRIO ROCK1 TFRC FMNL3 SNAP23 DDRGK1 FLOT2 ARHGAP1 ACTC1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 SRGAP1 PLEKHG5 PREX1 ARHGAP42 PLD1 OPHN1 STBD1 ARHGDIB KTN1 PIK3R1 VAV1 LBR TMPO ARHGAP11A ARHGAP11B ARAP2 RASGRF2 TAGAP ARAP3 VAV2 BCR PLEKHG3 TIAM1 DEPDC1B PLEKHG4 PLEKHG6 VAMP3 ARHGDIA RHOA PIK3R2 ROCK2 LMAN1 ABR ARHGAP21 PGRMC2 RACGAP1 YKT6 PCDH7 CAV1 MCAM MCF2 ARHGAP26 VANGL1 ARHGAP32 DIAPH3 TMEM87A KALRN SCFD1 NET1 ANLN FAF2 VAV3 AKAP13 CCDC115 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 C1QBP VAPB EMC3 BCAP31 CAVIN1 PREX2 MYO9B MYO9A DLC1 STARD8 RTKN DAAM1 ARHGAP44 ARHGAP40 NGEF ARHGEF40 IQGAP1 ARHGAP45 IQGAP3 ERBIN ARHGEF25 ARHGEF28 ARHGAP19 HMOX2 ARHGAP18 STARD13 JUP ARHGAP22 ARHGAP9 ARHGAP20 ARHGAP8 RHPN1 RHPN2 ECT2 ARHGAP4 ACBD5 GMIP ARHGAP29 MACO1 ATP6AP1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 80%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.3 PI3K AKT activation NTRK1 PIK3CA IRS1 IRS2 NGF PIK3CB RHOA PIK3R2 PIK3R1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.2 BBSome-mediated cargo-targeting to cilium ARL6 CCT5 CCT4 CCT3 MCHR1 CCT2 SMO BBS2 BBS1 RAB3IP TCP1 BBS9 BBIP1 BBS7 TTC8 BBS5 BBS4 MKKS SSTR3 LZTFL1 BBS10 BBS12 CCT8 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 80%68877 Mitotic Prometaphase INCENP KIF2A SEC13 NUP133 KIF2C KIF2B SMC1A CENPE CENPF TAOK1 NUP160 PPP2CA PPP2CB NUP85 RAD21 PPP1CC TUBGCP2 NUP43 TUBGCP5 RANBP2 TUBGCP6 AURKB TUBGCP3 TUBGCP4 CSNK2A1 BUB1 CSNK2A2 TUBG2 CLASP2 CLIP1 RPS27 MZT2B MZT2A NME7 MAD1L1 STAG1 CSNK2B STAG2 MZT1 NUP37 NDC80 CDCA5 PDS5B SPDL1 PDS5A WAPL RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C ZW10 DSN1 NUMA1 RCC2 ZWINT AHCTF1 EML4 CEP57 NEK9 YWHAE XPO1 NEK6 CETN2 NEK7 CEP164 CCP110 ACTR1A NDEL1 PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA PPP2R5D NINL CEP290 YWHAG PPP2R1B CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 MIS12 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A DYNC1I1 HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 B9D2 DYNC1I2 KNL1 DCTN2 SPC24 SSNA1 SPC25 ERCC6L DCTN3 CCNB2 ZWILCH DYNC1LI1 CCNB1 DYNC1LI2 HAUS8 ITGB3BP KIF18A CENPA HAUS7 PRKAR2B CENPC CEP70 KNTC1 NCAPG CEP72 CEP192 NCAPD2 SMC4 CDCA8 CENPT NCAPH PCNT SMC2 CEP76 CENPU SGO1 CLASP1 CEP78 SGO2 SKA1 PLK4 SKA2 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A PMF1 NEDD1 CENPH CENPI CENPJ ALMS1 CDK1 CENPK CENPL CEP41 CENPM CEP43 CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 NUDC DYNLL2 SMC3 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.1 Nuclear events stimulated by ALK signaling in cancer EML4 MAPK1 CLTC NPM1 STAT3 MAPK3 CEBPB SKP1 STAT5A ALK CUL1 JUNB BCL2A1 KIF5B ZC3HC1 RBX1 FN1 RPS6 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 80%9701898 STAT3 nuclear events downstream of ALK signaling PRDM1 IL2RG HDAC1 SIN3A CD274 STAT3 EP300 HIF1A HDAC2 HDAC3 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.2 Pyrimidine catabolism UPP2 NT5M UPP1 UPB1 TYMP NT5C AGXT2 NT5C1A DPYS DPYD THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.2 Thromboxane signalling through TP receptor GNGT2 TBXA2R GNG10 GNG12 GNA13 AAMP GNG11 GNG13 GNAQ GNB2 GNA14 GNB1 GNB4 GNA15 GNG3 GNB3 GNG2 GNG5 GNB5 GNG4 GNA11 GNG7 GNGT1 GNG8 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME DATABASE ID RELEASE 80%9673240 Defective gamma-carboxylation of F9 GGCX F9 COX REACTIONS%REACTOME DATABASE ID RELEASE 80%140180 COX reactions PTGS1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.3 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest E2F7 E2F8 ARID3A CCNA2 E2F1 CCNA1 ZNF385A CCNE2 PCBP4 CCNE1 CDK2 CDKN1A CDKN1B TP53 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 80%209822 Glycoprotein hormones INHBB CGA INHBA TSHB INHA CGB8 INHBC FSHB INHBE LHB REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.3 Regulation of TLR by endogenous ligand FGB FGA HMGB1 FGG LY96 CD36 CD14 GSDME GSDMD S100A1 LBP TLR1 S100A9 TLR6 S100A8 TLR4 TLR2 APOB RET SIGNALING%REACTOME DATABASE ID RELEASE 80%8853659 RET signaling PDLIM7 PRKCA PIK3CD NRTN PIK3CB GRB7 SHC1 PIK3R3 GAB1 GAB2 PIK3R1 DOK1 DOK4 SHC3 DOK2 DOK5 PIK3CA DOK6 RAP1GAP PLCG1 SOS1 FRS2 GRB10 PSPN PRKACG PRKACB ARTN IRS2 GDNF GFRA1 PIK3R2 GFRA3 GFRA2 GFRA4 PRKACA MAPK7 SHANK3 PTPN11 RET SIGNALING BY APC MUTANTS%REACTOME%R-HSA-4839744.3 Signaling by APC mutants PPP2CA PPP2CB AMER1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.5 Interleukin-12 family signaling IL27RA P4HB LMNB1 PSME2 CAPZA1 HNRNPF CFL1 IL27 CRLF1 TALDO1 IL6ST CDC42 EBI3 TCP1 STAT1 PAK2 ARF1 RALA PITPNA BOLA2B CNN2 CA1 HNRNPDL STAT4 IL12B IL12A IL12RB1 IL12RB2 JAK1 CANX HSPA9 SERPINB2 ANXA2 STAT3 GSTO1 AIP MSN TYK2 IL23R IL10 MIF RPLP0 SOD2 SOD1 MTAP VAMP7 IFNG GSTA2 HNRNPA2B1 PDCD4 SNRPA1 LCP1 PPIA RAP1B IL23A JAK2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%R-HSA-140342.3 Apoptosis induced DNA fragmentation HMGB1 H1-1 H1-0 H1-3 KPNB1 H1-2 H1-5 H1-4 KPNA1 DFFB CASP3 DFFA HMGB2 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 80%5610785 GLI3 is processed to GLI3R by the proteasome PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 CSNK1A1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PRKACA PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 CUL1 UBB UBC PRKACG PRKACB RPS27A GSK3B GLI3 SUFU RBX1 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME DATABASE ID RELEASE 80%5619087 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.4 Regulation of necroptotic cell death FAS CASP8 UBA52 PDCD6IP CDC37 MLKL XIAP FLOT1 OGT TRAF2 UBB SDCBP UBC TNFSF10 RPS27A PELI1 RIPK1 FADD RIPK3 TNFRSF10B TNFRSF10A TRADD FASLG HSP90AA1 BIRC2 FLOT2 STUB1 BIRC3 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 80%162599 Late Phase of HIV Life Cycle TAF9B UBAP1 CHMP4A CHMP6 CHMP7 NUP62 NUP214 VPS28 NDC1 CHMP5 NEDD4L SEC13 NUP210 NUP133 TCEA1 CCNT2 CCNT1 NUP93 SUPT16H NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 ELOA2 RANBP2 GTF2B GTF2E1 CDK9 GTF2E2 RNMT NUP155 RNGTT TAF4B NUP153 NUP35 NUP37 TAF9 TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J RANGAP1 POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NELFA NCBP1 NELFE NCBP2 SUPT5H ELOB RANBP1 ELOC NMT1 GTF2F1 GTF2F2 XPO1 RCC1 RAN FURIN GTF2A1 GTF2A2 CCNH UBA52 TBP PDCD6IP CCNK UBB UBC CDK7 MNAT1 RPS27A GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 TSG101 ELL VPS4B VPS4A ERCC2 MVB12B MVB12A TAF7L PPIA VTA1 VPS37C NMT2 VPS37D VPS37A ELOA NUP107 VPS37B NUP188 CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 80%5423599 Diseases of Mismatch Repair (MMR) MSH3 MLH1 MSH6 MSH2 PMS2 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 80%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.8 Interleukin-7 signaling IRS1 HGF PIK3R3 PIK3R1 RAG2 H3C15 RAG1 TSLP SOCS2 SOCS1 JAK3 JAK1 SMARCA4 IL7R IRS2 STAT3 PIK3R2 BRWD1 IL2RG CRLF2 STAT5A STAT5B CISH IL7 H3C8 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 80%427359 SIRT1 negatively regulates rRNA expression SUV39H1 H2AX H3-3B H2AB1 H2AC19 RRP8 H2AC14 H2BC12L H2BC21 TBP SIRT1 H2BU1 H2AC8 H3C15 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ TAF1D H2BC15 TAF1B H2BC11 TAF1C TAF1A H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H3C8 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.1 Negative feedback regulation of MAPK pathway MAPK1 RAF1 MAPK3 MAP2K2 MAP2K1 BRAF RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.1 RHOB GTPase cycle CIT VANGL1 ARHGAP32 DIAPH3 DIAPH1 PKN3 SOWAHC ARHGEF10L MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 NET1 ARHGEF17 ANLN PKN2 AKAP13 PKN1 STK10 SLK RHOB STOM ARHGEF3 ARHGEF1 ARHGEF2 ROCK1 TFRC SNAP23 ARHGEF5 FLOT2 ARHGAP1 ACTC1 ARHGAP39 ARHGAP5 ARHGAP35 PREX1 OPHN1 CAVIN1 PIK3R1 MYO9B MYO9A DLC1 STARD8 RTKN VAV2 ARHGDIG BCR DEPDC1B DAAM1 VAMP3 PIK3R2 IQGAP3 ERBIN ROCK2 ARHGEF25 ABR ARHGEF28 ARHGAP21 RACGAP1 STARD13 JUP PCDH7 RHPN2 ECT2 CAV1 MCAM MCF2 ARHGAP26 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.2 FGFR1b ligand binding and activation FGF22 FGF10 FGF1 FGF2 FGF3 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 80%444209 Free fatty acid receptors FFAR3 GPR31 FFAR2 FFAR4 FFAR1 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 80%8878159 Transcriptional regulation by RUNX3 PSMD8 KRAS PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 TEAD1 PSMD2 PSMD3 PSMD1 CREBBP NOTCH1 MAML2 PSMA5 SRC MAML1 PSMA6 PSMA3 PSMA4 RBPJ PSMA1 KAT2B PSMA2 KAT2A PSME3 SNW1 EP300 PSME1 PSME2 HES1 MAML3 PSMD10 MAMLD1 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 TCF7L2 TCF7L1 MYC HDAC4 TCF7 PSMB10 LEF1 PSMB6 CTNNB1 RUNX3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 RUNX1 PSMB9 SEM1 TGFB1 CDKN2A PSMC5 SMAD3 PSMC6 PSMC3 MDM2 BRD2 CBFB PSMC4 PSMC1 SPP1 PSMC2 UBA52 SMAD4 ZFHX3 FOXO3 ITGAL SMURF2 UBB SMURF1 WWTR1 UBC RPS27A ITGA4 TEAD4 CCN2 BCL2L11 TEAD2 TEAD3 YAP1 CDKN1A JAG1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.2 Alpha-oxidation of phytanate SLC27A2 PHYH HACL1 SLC25A17 PECR DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME%R-HSA-4549349.2 Defective ALG2 causes CDG-1i ALG2 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 80%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.1 Maturation of protein 3a ST3GAL4 ST6GALNAC2 GALNT1 ST3GAL1 ST6GALNAC3 ST6GALNAC4 ST3GAL2 ST3GAL3 ST6GAL1 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 80%169911 Regulation of Apoptosis PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 OMA1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 OPA1 ARHGAP10 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 UBA52 UBB UBC RPS27A INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.1 InlA-mediated entry of Listeria monocytogenes into host cells RPS27A CTNNB1 CTNND1 CBLL1 UBB UBA52 CDH1 SRC UBC SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.1 Scavenging by Class F Receptors HSPH1 HSP90AA1 HYOU1 SCARF1 CALR APOB TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain NDRG1 TP63 TP73 TP53BP2 BIRC5 BCL2L14 BCL6 TP53I3 CHM PPP1R13B PERP RABGGTB RABGGTA TP53 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.1 Diseases of DNA Double-Strand Break Repair RAD50 RAD51 RAD51B RAD51C RAD1 DNA2 RFC5 RFC3 HUS1 RFC4 BLM RFC2 RPA2 MRE11 RHNO1 WRN RPA3 ATRIP RAD17 ATR SEM1 BRCA2 RAD9B RAD51AP1 RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.6 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.1 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 PI METABOLISM%REACTOME%R-HSA-1483255.5 PI Metabolism PIP4K2C PIK3CD PIK3CB PIP5K1A PIP5K1B PIP5K1C PIK3R4 PIK3R3 RAB4A MTMR9 MTMR7 BMX SYNJ1 INPP5J PITPNB PTEN SACM1L SBF1 ARF3 TNFAIP8 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 TPTE2 RUFY1 PTPN13 PIK3CG MTMR3 INPP5D MTMR8 PIK3R5 INPPL1 GDPD1 PIK3R1 GDPD3 TPTE GDPD5 PIK3CA PIK3R6 MTMR6 INPP5K PLEKHA1 PNPLA7 PLEKHA2 ARF1 OCRL PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 SYNJ2 PLEKHA8 PI4KB PNPLA6 MTMR1 PIK3C3 RAB5A PIK3R2 INPP5E VAC14 PI4K2B MTMR10 MTMR2 MTMR12 MTMR4 PIK3C2A PIP4P1 MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F PIP4K2A PI4K2A PIP4K2B DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME%R-HSA-5578997.2 Defective AHCY causes HMAHCHD AHCY DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.2 Defective CYP11A1 causes AICSR FDX2 FDXR CYP11A1 FDX1 VITAMIN E%REACTOME%R-HSA-8877627.1 Vitamin E TTPA VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 80%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 CERAMIDE SIGNALLING%REACTOME DATABASE ID RELEASE 80%193681 Ceramide signalling NGFR NGF SMPD2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.1 PKA-mediated phosphorylation of CREB PRKACG ADCY3 PRKACB ADCY2 ADCY1 ADCY8 ADCY7 ADCY9 ADCY6 ADCY5 PRKAR1B PRKAR1A NBEA PRKAR2A PRKACA PRKX CREB1 PRKAR2B CALM1 ADCY4 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 80%170660 Adenylate cyclase activating pathway ADCY3 GNAL ADCY2 ADCY1 ADCY8 ADCY9 ADCY7 ADCY6 ADCY5 ADCY4 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.3 Defective PGM1 causes CDG1t PGM1 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 80%5603037 IRAK4 deficiency (TLR5) TLR5 IRAK4 MYD88 TLR10 MET INTERACTS WITH TNS PROTEINS%REACTOME%R-HSA-8875513.1 MET interacts with TNS proteins TNS4 TNS3 ITGB1 HGF MET RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.3 RHO GTPases regulate CFTR trafficking CFTR RHOQ GOPC HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%2022928 HS-GAG biosynthesis HS6ST1 HS6ST2 HS2ST1 SLC35D2 HS6ST3 NDST2 NDST1 NDST4 NDST3 HS3ST3B1 SDC4 GLCE HS3ST3A1 SDC2 SDC3 GPC1 HS3ST5 GPC3 HS3ST6 HS3ST4 HS3ST1 SDC1 GPC2 HS3ST2 GPC5 EXT1 EXT2 GPC4 AGRN GPC6 HSPG2 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 80%6811555 PI5P Regulates TP53 Acetylation PIP4K2C ING2 EP300 PIP4P1 PIN1 MAP2K6 TP53 PIP4K2A PIP4K2B DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 80%9630747 Diseases of Cellular Senescence CDK6 CDKN2A CDK4 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 80%913531 Interferon Signaling NUP62 NUP214 NDC1 HLA-DQA2 SEC13 NUP210 HLA-DQA1 CAMK2B NUP133 CAMK2D CAMK2A PIAS1 NUP93 HLA-DQB2 HLA-DQB1 NUP50 NUP54 SP100 NUP205 POM121 AAAS NUP160 CAMK2G POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 XAF1 EIF4G3 EIF4G2 FCGR1BP EIF4E3 NUP155 UBE2N EIF4E2 NUP153 IFNAR1 PML NUP35 B2M NUP37 PDE12 SOCS3 SOCS1 IFI6 IFITM3 EIF4A3 IFITM1 IFITM2 IFIT5 IFIT1 IFIT3 IFIT2 HLA-H HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E EGR1 USP41 USP18 NEDD4 ABCE1 KPNA2 PTPN6 KPNB1 OASL SUMO1 OAS1 OAS2 OAS3 IFNA5 IFNA4 IFNA7 IFNA6 IFNA2 UBE2L6 IFNA8 GBP2 HERC5 GBP1 STAT1 GBP4 UBA52 GBP3 TRIM25 GBP6 GBP5 IFNA13 GBP7 PRKCD IFNA14 IFNA16 DDX58 IFNA17 UBB IRF3 IRF7 UBC IFNA10 JAK1 RPS27A UBA7 TYK2 HLA-DPA1 IFNA21 IFNG IFNB1 ISG15 RNASEL PIN1 PTPN11 FLNB STAT2 JAK2 HLA-DPB1 KPNA7 KPNA4 KPNA5 IRF1 KPNA3 IRF2 HLA-DRB5 HLA-DRB4 FLNA UBE2E1 EIF2AK2 HLA-DRB3 EIF4E HLA-DRB1 HLA-DRA PPM1B PTAFR MAPK3 FCGR1A PSMB8 KPNA1 PTPN1 EIF4G1 EIF4A2 EIF4A1 IFI35 IFI30 RSAD2 IFI27 IP6K2 CIITA PLCG1 TRIM68 TRIM62 ARIH1 TRIM46 TRIM48 TRIM45 TRIM35 TRIM38 TRIM31 TRIM34 NCAM1 ICAM1 MT2A TRIM29 TRIM26 TRIM22 TRIM17 TRIM14 TRIM10 BST2 MID1 CD44 ISG20 IRF4 IRF8 IRF5 IRF6 IRF9 SAMHD1 MX2 MX1 VCAM1 ADAR TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 IFNGR1 NUP107 TRIM21 IFNGR2 NUP188 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.2 Mineralocorticoid biosynthesis HSD3B2 CYP11B2 CYP21A2 CGA HSD3B1 LHB PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 80%8857538 PTK6 promotes HIF1A stabilization PTK6 GPNMB HIF1A LRRK2 HBEGF EGFR TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 80%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC2 EXOSC1 ZFP36 TNPO1 YWHAB DCP1A MAPKAPK2 DIS3 XRN1 DCP2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME%R-HSA-3359471.2 Defective MMAB causes MMA, cblB type MMAB THE FATTY ACID CYCLING MODEL%REACTOME%R-HSA-167826.3 The fatty acid cycling model UCP1 SLC25A14 SLC25A27 UCP3 UCP2 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.2 alectinib-resistant ALK mutants ALK ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.3 Activation of caspases through apoptosome-mediated cleavage CYCS CASP3 XIAP CASP7 CASP9 APAF1 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 80%8875878 MET promotes cell motility CRKL LAMC2 LAMC1 RAC1 HGF GAB1 MET SRC CRK PTK2 RAPGEF1 TNS4 TNS3 DOCK7 LAMA5 LAMB2 LAMA3 LAMC3 ITGA2 LAMA4 ITGA3 ITGB1 LAMA2 LAMA1 RAP1B RAP1A LAMB3 LAMB1 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 80%9683686 Maturation of spike protein CANX MGAT1 PRKCSH MOGS GANAB SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.2 Sema4D in semaphorin signaling ARHGAP35 RHOA ERBB2 ROCK2 RAC1 RHOC MET PLXNB1 RND1 RHOB MYL12B MYH9 ARHGEF11 LIMK2 MYH14 ARHGEF12 LIMK1 MYH11 RRAS ROCK1 MYH10 MYL6 SEMA4D MYL9 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 80%5633008 TP53 Regulates Transcription of Cell Death Genes TP63 TP73 FAS TP53INP1 BCL6 CREBBP CASP10 BNIP3L STEAP3 IGFBP3 TP53AIP1 TP53 BAX NDRG1 BID PMAIP1 TP53BP2 BIRC5 BCL2L14 PRELID3A ZNF420 PRELID1 TNFRSF10C TP53I3 CHM TNFRSF10B TNFRSF10A BBC3 TNFRSF10D PPP1R13B ATM TRIAP1 AIFM2 PERP PIDD1 APAF1 CRADD CASP6 RABGGTB CASP1 RABGGTA CASP2 NLRC4 TMEM219 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 80%5578775 Ion homeostasis FXYD1 ORAI2 FXYD7 ORAI1 FXYD6 ITPR1 ITPR2 CAMK2B ITPR3 SRI CAMK2D CAMK2A ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 CALM1 CAMK2G KCNJ11 ABCC9 PRKACA TRPC1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 ATP1B3 ATP1B2 RYR1 NOS1 ATP1B1 RYR2 RYR3 ATP1A4 SLN ATP1A3 CLIC2 ATP1A2 TRDN ATP1A1 ASPH PLN AHCYL1 TNNI3 FXYD4 STIM1 DMPK FXYD3 FXYD2 FKBP1B GSD IB%REACTOME DATABASE ID RELEASE 80%3229133 GSD Ib SLC37A4 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 80%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 80%2559583 Cellular Senescence RPS6KA2 ANAPC11 BMI1 RPS6KA1 FZR1 CDC23 CDC26 CDC27 KDM6B E2F1 E2F2 RING1 E2F3 MAP2K6 ANAPC7 UBE2C MAPKAPK3 LMNB1 UBE2E1 MAPKAPK2 CDK6 H3C15 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 IL1A CDK2 ANAPC4 ANAPC5 MAPKAPK5 ANAPC1 ANAPC2 MRE11 RNF2 RELA MAPK1 MAPK3 CBX8 PHC2 NFKB1 PHC1 MAP2K3 CBX4 CDKN2A CBX2 CEBPB MDM2 MDM4 ATM PHC3 MAPK11 H3-3B TINF2 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP CDKN2D CDKN2B CDKN2C ACD H3-4 IL6 HMGA1 ETS1 ETS2 MAP3K5 ERF TNIK ASF1A EP400 HMGA2 H1-1 ID1 H1-0 CABIN1 H1-3 VENTX H1-2 MOV10 MINK1 H1-5 HIRA H1-4 UBN1 EZH2 MAP4K4 CXCL8 MAP2K4 MAPK14 SUZ12 MAP2K7 JUN TP53 FOS MAPK9 MAPK8 MAPK10 AGO3 AGO4 CBX6 AGO1 EED MAPK7 KAT5 SP1 NBN TNRC6C TNRC6A RAD50 TNRC6B H2AX H2AB1 H2AC19 H2AC14 H2BC12L UBA52 H2BC21 IGFBP7 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 EHMT1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB RBBP4 UBC RBBP7 H2AZ1 H2BC9 RPS27A H2AZ2 STAT3 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 IFNB1 H2AC20 EHMT2 RB1 CDKN1A H3C8 UBE2D1 ANAPC15 CDKN1B RPS6KA3 ANAPC16 ANAPC10 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.2 DNA Double Strand Break Response HERC2 PIAS4 RNF168 TP53 MRE11 MAPK8 KPNA2 CHEK2 UBE2N KAT5 UBE2I ATM SUMO1 NBN UBXN1 BARD1 BABAM1 BABAM2 UIMC1 BAZ1B ABRAXAS1 RNF8 BRCC3 KDM4B RAD50 APBB1 TP53BP1 KDM4A H2AX EYA1 EYA2 EYA3 EYA4 UBE2V2 PPP5C BAP1 H2BC12L H2BC21 UBA52 H2BU1 ABL1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 NSD2 UBB UBC H2BC9 RPS27A H4C9 H2BC8 H2BC5 H3-4 H2BC3 SMARCA5 H2BC1 MDC1 BRCA1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 80%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 80%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.5 HSP90 chaperone cycle for SHRs HSP90AB1 DYNLL1 DYNC1I1 DCTN6 DCTN5 HSPA1B DCTN1 HSPA1A ACTR10 DCTN4 NR3C2 DNAJA1 DYNC1I2 DNAJA4 DCTN2 DNAJA2 FKBP5 DCTN3 AR DYNC1LI1 FKBP4 DYNC1LI2 CAPZA3 CAPZA1 CAPZA2 DNAJB1 ACTR1A DYNC1H1 HSPA1L PTGES3 HSPA2 HSPA8 PGR CAPZB HSP90AA1 STIP1 NR3C1 DYNLL2 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 80%8866376 Reelin signalling pathway SH3KBP1 DAB1 RELN FYN VLDLR PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.3 Proton-coupled monocarboxylate transport BSG SLC16A1 SLC16A7 SLC16A8 EMB SLC16A3 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 80%8878166 Transcriptional regulation by RUNX2 PSMD8 PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 HEY1 PSMD2 HEY2 PSMD3 PSMD1 SKP2 PSMA5 SRC PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 AKT2 PSME3 PSME4 PSME1 CDK4 AKT1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BAX PSMA7 WWP1 PSMB10 MAPK1 PSMA8 PSMB6 MAPK3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 RUNX1 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CBFB PSMC4 PSMC1 PSMC2 HDAC3 COL1A1 PPARGC1A SMURF1 YES1 GSK3B GLI3 GLI2 TWIST1 LGALS3 AKT3 IHH ESR1 HES1 MSX2 MAF DLX5 DLX6 TWIST2 HIVEP3 PPARGC1B HDAC6 ESRRA SMAD1 SMAD6 HDAC4 BMP2 ITGBL1 SATB2 SP7 UCMA ZNF521 NKX3-2 MMP13 RBM14 HAND2 ITGA5 PPM1D BGLAP SKP1 STUB1 NR3C1 STAT1 UBA52 SMAD4 ABL1 CUL1 AR CCNB1 UBB WWTR1 UBC RPS27A SOX9 CDK1 YAP1 RB1 RBX1 CDKN1A HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 80%5693579 Homologous DNA Pairing and Strand Exchange RAD50 RAD51 RAD51B RAD51C RAD1 DNA2 RFC5 RFC3 HUS1 RFC4 BLM RFC2 RPA2 MRE11 RHNO1 WRN RPA3 ATRIP XRCC3 RAD17 CHEK1 ATR SEM1 BRCA2 RAD9B RAD51AP1 RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 80%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity NSF PRKCG PRKCA GRIP2 GRIP1 TSPAN7 PICK1 GRIA3 GRIA4 CAMK2B GRIA1 GRIA2 CAMK2D PRKCB CAMK2A CACNG8 DLG1 CACNG2 CACNG3 CACNG4 DLG4 CAMK2G EPB41L1 MYO6 AP2A1 AKAP5 MDM2 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 80%5602415 UNC93B1 deficiency - HSE TLR3 UNC93B1 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 80%3000157 Laminin interactions ITGAV COL18A1 LAMC2 LAMC1 HSPG2 ITGB4 LAMA5 NID2 LAMB2 ITGA7 ITGA6 LAMA3 LAMC3 ITGA2 LAMA4 ITGA3 ITGA1 ITGB1 LAMA2 LAMA1 NID1 LAMB3 LAMB1 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.3 RNA Polymerase I Transcription HDAC2 H3C15 KAT2B KAT2A MBD3 GATAD2B GATAD2A MAPK3 CHD4 CHD3 MTA1 MTA2 MTA3 CCNH HDAC1 H2AX H3-3B H2AB1 TTF1 H2AC19 H2AC14 UBTF H2BC12L CAVIN1 H2BC21 TBP H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 H2AJ H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E POLR2F TAF1A RBBP4 POLR2H RBBP7 H2AZ1 MBD2 POLR2K H2BC9 CDK7 POLR2L MNAT1 H2AZ2 GTF2H1 H4C9 H2BC8 GTF2H2 GTF2H3 GTF2H4 H2BC5 GTF2H5 H2BC3 H2BC1 ERCC3 H2AC20 ERCC2 EHMT2 RRN3 CBX3 H3C8 ERCC6 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.6 Synthesis of PA GPAT4 GPAT3 GPAT2 PLD6 PLA2G5 PLA2G2F PLD1 PLA2G2D PLA2G2E PLD2 PLA2G2A DDHD2 DDHD1 GPAM LPCAT4 ALPI GPD1L LPCAT1 ACP6 LCLAT1 PLA2G12A LIPI LIPH PLA2G4D PLA2G4B PLA2G4A MIGA2 MIGA1 GNPAT AGPAT5 GPD2 PLA2G10 PLA2G1B GPD1 AGPAT1 AGPAT2 PLA2R1 AGPAT3 AGPAT4 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 80%9683701 Translation of Structural Proteins ST6GALNAC2 GSK3A PRKCSH UBA52 GANAB ST3GAL4 MGAT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 UBB MOGS PARP10 PARP6 PARP4 PARP16 UBC PARP9 PARP14 PARP8 RPS27A CANX GALNT1 ST6GALNAC3 ST6GALNAC4 GSK3B UBE2I SUMO1 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.2 Diseases of glycosylation CFP B4GALT7 B3GAT3 EXT1 EXT2 ALG2 MUC13 MUCL1 DPM1 DPM2 DPM3 CHST3 NOTCH2 PAPSS2 NOTCH3 NOTCH4 SDC4 NCAN SDC2 SDC3 BGN SPON2 B3GALT6 SEMA5B VCAN SPON1 GPC1 THSD7B GPC3 B3GLCT CSPG5 SDC1 PGM1 THBS2 ADAMTS12 GPC2 THBS1 GPC5 CSPG4 THSD1 THSD4 GPC4 ADAMTS10 AGRN ADAMTSL1 GPC6 ADAMTS15 ADAMTS2 MUC5AC ADAMTS14 ADAMTS3 ADAMTS13 ADAMTSL5 HSPG2 ADAMTSL4 BCAN ADAMTS19 ADAMTSL3 ADAMTSL2 ADAMTS17 THSD7A HEXB ADAMTS6 HEXA ADAMTS7 SBSPON SSPOP ADAMTS20 GALE ADAMTS16 ADAMTS18 GALNT12 POMT2 POMT1 LFNG C1GALT1C1 GNE LARGE1 POMGNT1 C1GALT1 NOTCH1 B4GAT1 ADAMTS4 ADAMTS5 ADAMTS1 SEMA5A ADAMTS8 ADAMTS9 GALNT3 DCN NEU1 SLC26A2 DPAGT1 ALG8 CTSA ALG9 ALG6 MUC12 ALG14 ACAN ALG13 MUC15 ALG3 ALG12 ALG1 CHST14 MPDU1 RFT1 CHSY1 GLB1 MUC1 MUC2 MUC7 MUC4 MUC6 NUS1 DHDDS MUC3A MGAT2 MUC3B GFPT1 ST3GAL3 MOGS MUC16 MUC17 MUC19 MUC20 CHST6 MUC21 MAN1B1 LUM DAG1 OGN OMD KERA PRELP ALG11 FMOD B4GALT1 MUC5B GALT SRD5A3 MPI PMM2 DOLK GALK1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.4 Synaptic adhesion-like molecules PTPRF LRFN3 PTPRD LRFN2 LRFN4 LRFN1 GRIA3 GRIA4 GRIA1 GRIN2C GRIN2B GRIN1 FLOT1 GRIN2D GRIN2A DLG1 DLG3 DLG4 FLOT2 RTN3 PTPRS LIPOPHAGY%REACTOME DATABASE ID RELEASE 80%9613354 Lipophagy PRKAG3 PRKAB1 PLIN3 PLIN2 PRKAA2 PRKAB2 HSPA8 PRKAG1 PRKAG2 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.2 Metabolism of ingested SeMet, Sec, MeSec into H2Se NNMT CBS CTH AHCY SCLY HNMT GNMT MAT1A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 80%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known BMI1 ACTL6A HIPK2 RING1 SMARCD1 SMARCD2 SMARCB1 SMARCD3 ARID2 YAF2 SMARCE1 SMARCC1 PBRM1 SMARCC2 ACTL6B EP300 AUTS2 PCGF5 ARID1A SMARCA2 ARID1B RYBP RNF2 SMARCA4 CBX6 CBX8 PHC2 PHC1 RUNX1 CBX4 CSNK2A1 CBX2 CSNK2A2 CBFB PHC3 CSNK2B BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.4 Branched-chain amino acid catabolism MCCC1 BCKDHB PPM1K ACADSB BCKDK ALDH6A1 AUH IVD HSD17B10 BCAT1 SLC25A44 HIBCH BCAT2 ACAT1 DBT DLD ECHS1 BCKDHA MCCC2 ACAD8 HIBADH MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.1 mRNA decay by 5' to 3' exoribonuclease LSM1 LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DCP1A EDC3 DCP1B EDC4 PATL1 XRN1 DCP2 DDX6 SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.4 SARS-CoV Infections RPS11 RPS10 ATG14 RPS13 ZCRB1 RPS12 NUP62 NUP214 RPS9 NDC1 RPS7 SEC13 RPS8 NUP210 RPS5 NUP133 RPSA RPS3A YWHAQ NUP93 UBE2V1 YWHAH NUP50 NUP54 NUP205 POM121 RPS4Y2 AAAS NUP160 YWHAZ RPS27L RPS4Y1 POM121C RPS15A NUP42 NUP85 RPS3 RPS2 TPR NUP88 NUP43 RAE1 RANBP2 MAP1LC3B NUP155 RPS26 UBE2N VHL RPS25 TAB3 RPS28 TAB2 RPS27 TAB1 RPS29 NUP153 IFNAR1 RPS20 IMPDH1 FAU ROCK1 IMPDH2 RPS21 RPS24 NUP35 B2M RPS23 NUP37 PDPK1 TRAF6 IL17RC IL17RA HLA-H HLA-B GSK3B HLA-C HLA-A HLA-F HLA-G HLA-E GSK3A CSNK1A1 AKT3 CREBBP TLR9 TLR8 TLR7 ZBP1 MBD3 GATAD2B GATAD2A S1PR1 YWHAE KPNA2 PTPN6 IRAK1 CUL3 NLRP3 GEMIN2 TLR1 SNRPD2 CHD4 SNRPD1 CHD3 SNRPD3 YWHAG TLR2 KDM1A GEMIN4 UBE2I SNRPG HSP90AA1 MTA1 GEMIN5 SUMO1 GEMIN6 MTA2 SNRPE MTA3 GEMIN7 IFNA5 TUBB SNRPF REST IFNA4 GEMIN8 SNRPB NR3C1 UVRAG DDX20 IFNA7 IFNA6 SMN2 HSP90AB1 IFNA2 ARID4B IFNA8 IFIH1 STAT1 TRIM4 UBA52 GJA1 PHF21A SAP30 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 SIKE1 UBB IRF3 SAP30L TRAF3 IRF7 SAP18 UBC SUDS3 IFNA10 JAK1 RPS27A GALNT1 RCOR1 RNF135 TKFC TYK2 RIPK1 PATJ SFN VPS39 ARID4A VPS18 COMT IFNA21 LARP1 CYSLTR1 VPS11 IFNB1 FNTA VPS16 FNTB ISG15 SRPK2 SIGMAR1 SRPK1 ATP1B3 SFTPD ATP1B2 NLRP12 ATP1B1 MAVS CRB3 BRMS1 VPS33A ATP1A4 G3BP1 HMG20B ATP1A3 PTPN11 RB1 G3BP2 ATP1A2 PALS1 ATP1A1 BRD4 RBX1 CHMP2B CNBP CRBN CHMP4C VPS41 FXYD4 CHMP2A FXYD3 STAT2 CHMP4B FXYD2 JAK2 CHMP3 FXYD1 IKBKB FXYD7 CHMP4A FXYD6 CHMP6 NFE2L2 CHMP7 IL1R1 IKBKG MAP3K7 CHUK YWHAB HDAC2 AKT2 RIPK2 AKT1 NOD1 NOD2 RPS6 JAK3 VPS45 FKBP1A SEC23A VPS33B IL6R SEC24B SEC24A ITGB1 SEC24D SEC24C TBK1 STING1 TUFM HDAC1 ZDHHC8 VCP SDC4 SAR1B SDC2 SDC3 GPC1 GPC3 SDC1 GPC2 MBL2 GPC5 IRAK2 GPC4 ITGA4 AGRN GPC6 PIK3C3 ROCK2 HSPG2 BECN1 PDCD1 CAV1 PIK3R4 CTSL TJP1 FKBP4 IL17F IL17A TMPRSS2 PTGES3 ACE2 MASP1 DDX5 FURIN PRMT1 ST6GALNAC2 RPN2 TUSC3 ZDHHC20 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 GOLGA7 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS PARP10 PARP6 ZDHHC11 PARP4 DDOST PARP16 RBBP4 MGAT4C PARP9 ZDHHC9 RBBP7 PARP14 DAD1 PARP8 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 RPS4X KEAP1 RPS15 RPS14 RPS17 RPS16 RPS19 IFNGR1 NUP107 RPS18 IFNGR2 NUP188 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 80%1299344 TWIK-related spinal cord K+ channel (TRESK) KCNK18 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 80%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 H3C15 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 TCF3 PSMB7 LDB1 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 SPI1 PSMF1 PSMB8 RUNX1 PSMB9 TAL1 SEM1 PSMC5 PSMC6 KMT2A PSMC3 CBFB PSMC4 PSMC1 PSMC2 H3-3B TCF12 ITCH MYB TP73 CCNH H2AX H2AB1 H2AC19 H2AC14 GATA3 H2BC12L GATA2 UBA52 GATA1 H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 ABL1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB UBC H2AZ1 CDK7 H2BC9 MNAT1 RPS27A H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 YAP1 H3C8 LMO1 LMO2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 80%420499 Class C 3 (Metabotropic glutamate pheromone receptors) TAS2R60 TAS2R40 TAS2R9 TAS2R41 TAS2R8 TAS2R20 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM3 GPRC6A GRM2 GRM5 GRM4 GRM7 GRM6 GRM8 TAS2R1 TAS1R2 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 CASR TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 TAS2R16 TAS2R39 TAS2R19 GABBR2 GABBR1 TAS2R7 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-HSA-499943.6 Interconversion of nucleotide di- and triphosphates NME1 GUK1 TXNRD1 TYMS RRM2 NME2 DTYMK AK1 AK2 AK4 GLRX AK5 AK6 AK7 AK8 AK9 NME2P1 NUDT13 RRM1 NME3 CTPS2 NME4 CTPS1 DCTD CMPK1 DCTPP1 RRM2B REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 80%1234158 Regulation of gene expression by Hypoxia-inducible Factor CITED2 EPO EPAS1 EP300 ARNT VEGFA CA9 HIF1A HIGD1A CREBBP ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.2 Activation of AMPK downstream of NMDARs PRKAG3 PRKAB1 CAMKK2 PRKAA1 PRKAA2 PRKAB2 CALM1 PRKAG1 PRKAG2 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 80%9706377 FLT3 signaling by CBL mutants RPS27A FLT3 FLT3LG UBB UBA52 CBL UBC LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 80%9717329 lorlatinib-resistant ALK mutants ALK SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006927.3 Signaling by Non-Receptor Tyrosine Kinases CCND1 PELP1 DOK1 DOCK1 NRG1 PXN CDK4 AKT1 CCNE1 CDK2 ARAP1 RASA1 STAP2 PTPN1 SRMS PTK6 SFPQ KHDRBS1 KHDRBS2 NR3C1 KHDRBS3 BCAR1 ARHGAP35 RAC1 HIF1A EGF UBA52 CBL EGFR NRAS CRK SOCS3 HRAS EPAS1 BTC NRG3 NRG4 NRG2 HBEGF EREG UBB UBC RPS27A RHOA STAT3 ERBB2 ELMO2 GPNMB LRRK2 ELMO1 CDKN1B DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 80%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.2 Platelet Aggregation (Plug Formation) THPO FGB FGA TLN1 VWF PDPK1 GP1BB ADRA2C SHC1 FGG GP1BA ADRA2B F2 ADRA2A SRC GP5 GP9 CRK SOS1 AKT1 PTK2 RASGRP2 RASGRP1 SYK RAPGEF3 RAPGEF4 PTPN1 ITGB3 CSK ITGA2B RAP1B RAP1A FN1 MPL APBB1IP BCAR1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 80%3238698 WNT ligand biogenesis and trafficking VPS29 WNT2B WNT8A WNT8B VPS26A SNX3 WNT6 PORCN VPS35 WNT2 TMED5 WNT3 WNT4 WLS WNT10A WNT5B WNT3A WNT7B WNT9B WNT7A WNT9A WNT16 WNT1 WNT10B WNT5A WNT11 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 80%112313 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.5 Signaling by NOTCH HDAC10 HDAC11 DNER TLE4 TLE2 HDAC8 TLE1 DTX1 DTX2 HDAC9 DLK1 YWHAZ HDAC7 CNTN1 RAB6A H3-3B SIRT6 ELF3 NOTCH2 NOTCH3 NOTCH4 ATP2A3 ATP2A2 ATP2A1 NUMB ITCH CREBBP MOV10 NOTCH1 MAML2 MAML1 RBPJ KAT2B KAT2A SNW1 EP300 DTX4 HES1 MAML3 MAMLD1 JUN TP53 AGO3 AGO4 AGO1 AGO2 JAG2 NBEA MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SMAD3 SKP1 HDAC5 TNRC6C TNRC6A TNRC6B HIF1A STAT1 UBA52 GZMB CUL1 UBB UBC PRKCI RPS27A H3C8 RBX1 PSMD8 PSMD9 PSMD6 PSMD7 WWC1 PSMD4 CCND1 YBX1 PSMD5 HEY1 PSMD2 HEY2 PSMD3 E2F1 HES5 PSMD1 DLGAP5 PTCRA E2F3 HEYL TACC3 PSMA5 PSMA6 HDAC2 PSMA3 PSMA4 H3C15 PSMA1 TFDP1 PSMA2 PSME3 TFDP2 WWP2 PSME1 AKT1 PSME2 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYC PLXND1 ACTA2 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 RUNX1 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X EGF EGFR SEL1L PBX1 TMED2 RFNG POGLUT1 POFUT1 MFNG MDK ADAM10 ADAM17 PSEN1 JAG1 NCSTN ST3GAL6 LFNG HDAC6 HDAC4 FABP7 FURIN CCNC H2AX H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 H2AC6 ST3GAL4 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 ST3GAL3 H2AJ CREB1 H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 APH1A PSENEN APH1B H2BC5 H2BC3 PSEN2 B4GALT1 H2BC1 H2AC20 FLT4 ARRB1 ARRB2 FCER2 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.2 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 KLK3 H2BU1 H2AC8 H3C15 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 AR H2AJ H2BC15 H2BC11 H2AZ1 PKN1 H2BC9 H2AZ2 H4C9 NCOA2 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A KDM4C KLK2 H3C8 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.1 Resistance of ERBB2 KD mutants to tesevatinib CDC37 HSP90AA1 ERBB2 ERBIN DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 80%9656256 Defective OGG1 Substrate Processing OGG1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 80%418457 cGMP effects PDE5A PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE2A PRKG2 IRAG1 PDE10A KCNMA1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 80%201681 TCF dependent signaling in response to WNT TLE4 TLE2 TLE1 WNT1 YWHAZ AMER1 CSNK2A1 CSNK2A2 CSNK2B AXIN2 H3-3B TERT SMURF2 H3-4 PPP2R5E GSK3B PPP2R5B PPP2R5A PPP2R5C ASH2L PIP5K1B CSNK1A1 CREBBP XIAP EP300 RNF146 TNKS CUL3 PPP2R1A BTRC KAT5 TNKS2 CSNK1E UBA52 RBBP5 UBB CTBP1 UBC RPS27A SOX2 SOX9 WNT5A FZD2 FZD5 H3C8 RBX1 FZD4 FZD6 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 H3C15 PSMA1 PSMA2 AKT2 PSME3 PSME4 PSME1 AKT1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA TCF7L2 PPP2CB TCF7L1 MYC TCF7 PSMB10 PSMA8 LEF1 PSMB6 CTNNB1 RUNX3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 MEN1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DVL1 DVL2 DVL3 HDAC1 WNT8A WNT8B WNT3 WNT4 WNT3A WNT9A TRRAP SOX3 FRAT1 FRAT2 SOX17 SOX6 SOX7 SOX4 SOX13 DKK1 DKK2 DKK4 SFRP1 SFRP2 HECW1 FZD1 FZD8 RSPO2 RSPO3 RSPO1 RSPO4 KREMEN1 KREMEN2 WIF1 RYK LGR6 LGR5 CDC73 LGR4 USP8 RNF43 CAV1 CTNNBIP1 PYGO1 PYGO2 LEO1 KLHL12 CCDC88C BCL9L BCL9 CXXC4 CHD8 USP34 CBY1 SOST DACT1 LRP5 LRP6 ZNRF3 KMT2D CSNK1G2 XPO1 PPP2R5D TLE3 PPP2R1B SRY APC AXIN1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 RUVBL1 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 SMARCA4 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 THE PROTON BUFFERING MODEL%REACTOME%R-HSA-167827.2 The proton buffering model UCP1 SLC25A14 SLC25A27 UCP3 UCP2 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.2 Signaling by NTRK1 (TRKA) RPS6KA2 RPS6KA1 TPH1 ATF1 MAP2K5 SH3GL2 YWHAB MAPKAPK3 MAPKAPK2 KIDINS220 BRAF PPP2CA PPP2CB MAPK1 MAPK3 MAPK11 CDK5R1 CLTC CLTA SHC1 PIK3R1 MAPK12 MAPK13 NRAS PIK3CA PLCG1 CRK SOS1 HRAS RAPGEF1 MAP2K1 NGF RHOA PIK3R2 SRF DNM1 DNM2 DNM3 ATF2 MEF2D NAB1 NAB2 IRS1 CRKL PIK3CB ID1 TCF12 EGR1 SH3GL3 ARC TRIB1 SHC2 SHC3 RRAD RALGDS EGR3 EGR4 FOSL1 ID2 ADCYAP1 ID4 EP300 ID3 DNAL4 ADCYAP1R1 LYL1 MAPK14 RALB ASCL1 RIT1 RIT2 CDK5R2 FOS IRS2 PPP2R1A DUSP4 DUSP3 PPP2R5D VRK3 CHD4 DUSP6 NTRK1 DUSP7 NTRK2 MAPK7 PPP2R1B JUND REST ADORA2A FOSB F3 JUNB FRS2 ELK1 RALA CREB1 EGR2 CDK5 VGF STAT3 AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 RAP1A MAP2K2 MEF2A SGK1 MEF2C RPS6KA3 RPS6KA5 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 80%9702509 FLT3 mutants bind TKIs FLT3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 80%76042 RNA Polymerase II Transcription Initiation And Promoter Clearance TAF9B TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2B GTF2E1 GTF2E2 ERCC3 ERCC2 TAF4B TAF7L GTF2A1 GTF2A2 RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.2 RHOBTB2 GTPase cycle CCT7 HSP90AB1 CCT2 TMOD3 MSI2 CUL3 TXNL1 MYO6 TWF1 TRA2B CCT6A CDC37 HNRNPC SRRM1 DDX39B RBMX HSP90AA1 PHIP RHOBTB2 ACTG1 DBN1 ACTN1 STK38 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME%R-HSA-2995383.5 Initiation of Nuclear Envelope (NE) Reformation SIRT2 PPP2CA PPP2R2A ANKLE2 PPP2R1A KPNB1 EMD LBR LMNB1 CDK1 LEMD3 CCNB2 CCNB1 VRK1 BANF1 LEMD2 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.2 SUMOylation of RNA binding proteins BMI1 SUMO2 NUP62 NUP214 NDC1 SEC13 NUP210 RING1 NUP133 NUP93 NOP58 NUP50 NUP54 NUP205 POM121 AAAS NUP160 HNRNPK RNF2 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 CBX8 PHC2 PHC1 NUP155 CBX4 HNRNPC CBX2 PCGF2 UBE2I NUP153 SUMO1 PHC3 NUP107 NUP188 NUP35 NUP37 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 80%432047 Passive transport by Aquaporins AQP12A AQP8 AQP10 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 MIP AQP11 AQP1 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.2 Histamine receptors HRH1 HRH3 HRH2 HRH4 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 80%8941326 RUNX2 regulates bone development HEY1 HEY2 COL1A1 SRC IHH SMAD4 ABL1 HES1 AR MAF WWTR1 HDAC6 SMAD1 HDAC4 SMAD6 MAPK1 YES1 SATB2 MAPK3 SP7 UCMA ZNF521 RBM14 BGLAP CBFB YAP1 GLI3 GLI2 RB1 HDAC3 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 80%196780 Biotin transport and metabolism MCCC1 PCCB ACACB PDZD11 ACACA PC SLC5A6 MCCC2 BTD PCCA HLCS SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 80%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AKR1D1 AKR1C3 SLC27A2 AKR1C2 AKR1C4 CYP27A1 AMACR SLC27A5 CYP46A1 CYP39A1 PTGIS CYP8B1 HSD3B7 AKR1C1 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 80%1462054 Alpha-defensins PRSS2 ART1 DEFA6 DEFA4 CD4 DEFA5 DEFA3 DEFA1B PRSS3 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 80%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) PLCG1 EPO IRS2 EPOR LYN PLCG2 JAK2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.3 G1 S-Specific Transcription RBL2 RBL1 HDAC1 E2F4 E2F5 FBXO5 E2F1 DHFR CCNA1 TK1 TYMS E2F6 PCNA RRM2 TFDP1 TFDP2 CCNE1 ORC1 CDT1 RBBP4 CDC6 POLA1 LIN54 LIN52 CDK1 CDC45 LIN37 LIN9 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 80%8878171 Transcriptional regulation by RUNX1 BMI1 RING1 NFATC2 SRC PRKCQ RNF2 CSF2 TCF3 LDB1 CBX8 PHC2 PHC1 CSNK2A1 CBX4 CSNK2A2 CBX2 PHC3 PML CSNK2B KCTD6 H3-3B KMT2E CR1 SOCS3 KMT2B DPY30 SETD1B SETD1A ASH2L TCF12 ITCH CREBBP MOV10 KAT2B GPAM EP300 LIFR AGO3 AGO4 AGO1 CBX6 AGO2 BLK ELF1 ELF2 PAX5 TNRC6C MYB WDR5 TNRC6A TNRC6B TP73 ACTL6A CCNH ZFPM1 SIN3B GATA3 GATA2 UBA52 GATA1 SMARCD1 SMARCD2 SMARCB1 ARID2 SMARCD3 YAF2 SMARCE1 SMARCC1 PBRM1 ABL1 SMARCC2 NFE2 ACTL6B AUTS2 PCGF5 RBBP5 ARID1A SMARCA2 ARID1B RYBP UBB MYL9 UBC CDK7 RPS27A MNAT1 CTLA4 IFNG PTPN11 H3C8 LMO1 LMO2 PSMD8 PSMD9 CCND3 PSMD6 PSMD7 CCND2 PSMD4 CCND1 PSMD5 PSMD2 PSMD3 HIPK2 PSMD1 PRKCB PSMA5 PSMA6 PSMA3 PSMA4 H3C15 CDK6 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 FOXP3 PSMB5 PSMB2 PSMB3 PSMB1 SPI1 PSMF1 PSMB8 RUNX1 PSMB9 TAL1 SEM1 PSMC5 PSMC6 PSMC3 KMT2A PSMC4 CBFB PSMC1 PSMC2 HDAC1 SIN3A THBS1 TNFRSF18 RSPO3 IL2RA LGALS3 CTSV OCLN KMT2D CTSL KMT2C ESR1 CTSK PRMT6 NR4A3 TJP1 CLDN5 IL2 SERPINB13 SOCS4 IL3 AXIN1 PRMT1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L GP1BA H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ PF4 H2BC15 H2BC11 H2AZ1 H2BC9 SMARCA4 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ITGA2B YAP1 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.1 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 RB1 CDK2 CDKN1C CDKN1A CDKN1B CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-HSA-1234174.2 Cellular response to hypoxia CITED2 PSMD8 PSMD9 ELOB LIMD1 PSMD6 PSMD7 ELOC EGLN1 PSMD4 EGLN3 PSMD5 EGLN2 PSMD2 WTIP PSMD3 PSMD1 CREBBP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 EP300 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 EPO PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CUL2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 VHL SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HIF1AN ARNT CA9 HIGD1A UBE2D3 HIF1A UBA52 AJUBA EPAS1 UBB UBC RPS27A VEGFA UBE2D2 RBX1 UBE2D1 HIF3A NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 80%5675221 Negative regulation of MAPK pathway RAF1 PPP5C MAPK12 UBA52 YWHAB NRAS HRAS UBB MAP2K1 UBC BRAF PPP2CA PPP2CB RPS27A MAPK1 MAPK3 PTPN7 DUSP16 PPP2R1A DUSP10 DUSP4 PPP2R5D DUSP8 DUSP9 DUSP6 DUSP7 ARAF PEBP1 PPP2R1B PPP2R5E MARK3 BRAP DUSP5 DUSP2 MAP2K2 PPP2R5B KSR1 DUSP1 PPP2R5A PAQR3 PPP2R5C PTPN3 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME%R-HSA-5387390.4 Hh mutants abrogate ligand secretion PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SHH PSMA5 PSMA6 IHH PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HHAT DHH UBA52 VCP SEL1L DERL2 ERLEC1 OS9 SYVN1 UBB UBC RPS27A DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.2 Defective HLCS causes multiple carboxylase deficiency MCCC1 PCCB ACACA PC MCCC2 PCCA HLCS ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-HSA-549132.1 Organic cation anion zwitterion transport RSC1A1 SLC22A6 SLC22A5 SLC22A12 SLC22A15 SLC22A16 SLC22A8 SLC22A11 SLC22A2 SLC22A1 SLC22A7 RUNX1 SLC22A3 SLC22A18 SLC22A4 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME DATABASE ID RELEASE 80%196819 Vitamin B1 (thiamin) metabolism THTPA TPK1 SLC25A19 SLC19A3 SLC19A2 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 80%166786 Creation of C4 and C2 activators IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRP IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MBL2 C1S C1R C1QB C1QA C1QC FCN1 FCN2 FCN3 MASP1 COLEC11 COLEC10 IGHV3-23 IGLV IGLV2-8 IGKV1-16 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 80%3000497 Scavenging by Class H Receptors SPARC STAB1 STAB2 APOB CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.2 Carnitine synthesis TMLHE SHMT1 BBOX1 ALDH9A1 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME DATABASE ID RELEASE 80%9672393 Defective F8 binding to von Willebrand factor F8 VWF REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.1 Regulation of gene expression in early pancreatic precursor cells ONECUT1 HNF1B FGF10 PDX1 ONECUT3 NKX6-1 PTF1A DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 80%5579021 Defective CYP21A2 causes AH3 CYP21A2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.2 Voltage gated Potassium channels KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ5 KCNV1 KCNQ2 KCNV2 KCNQ3 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB3 KCNA10 KCNQ4 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNAB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9603381.1 Activated NTRK3 signals through PI3K PIK3CA IRS1 NTRK3 NTF3 PIK3R1 SRC GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 80%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMD8 PSMD9 PSMD6 NFE2L2 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 CUL1 UBB UBC RPS27A GSK3B RBX1 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 80%5653656 Vesicle-mediated transport SEC13 GRIA1 LNPEP CALM1 AVP HYOU1 SCARF1 SBF1 ARF3 PLA2G6 SBF2 CPD GDI2 BTC PICALM HBEGF SYNJ2 EREG PLA2G4A AGPAT3 PIP5K1C AKT3 YWHAE ACTR1A GRK2 RAB8A YWHAG HSP90AA1 CSNK1D GOLGA2 ITSN2 CUX1 DYNLL1 ITSN1 FNBP1L UBA52 GJA1 OPTN PAFAH1B1 FNBP1 DYNC1I2 DCTN2 DCTN3 ARF1 RALA DYNC1LI1 DYNC1LI2 UBB UBC GNS RPS27A DYNC1H1 MYO6 SFN VAMP7 CHM WNT5A ARPC1A FZD4 DYNLL2 NSF C2CD5 PLIN3 RALGAPA2 TBC1D1 GPS1 RALGAPB TBC1D4 PRKAA2 STXBP3 RAB4A ASPSCR1 RAB13 YWHAB PRKAG1 PRKAG2 PRKAG3 STX5 AKT2 AKT1 PRKAB2 TSC2 TSC1 PRKAB1 PAFAH1B2 STX4 CALR AP3B1 RHOBTB3 TFRC SNAP23 DVL2 FTL ARPC4 ARPC5 HSP90B1 COPS4 TXNDC5 ARPC2 EGF ARPC3 COPS2 CBL EGFR OCRL TMED2 ACTR3 ACTR2 SNAP29 ARFGAP3 RAB7A VAMP3 ARFGAP2 LMAN1 SYT1 RACGAP1 MYO1C YKT6 ZW10 CFTR SH3GL3 HBA2 SCFD1 SPTBN1 CLTCL1 STAM WASL RAB27A MYO5A HSPH1 SPTAN1 SPTB CTTN RHOQ ARF4 ANK2 DYNC1I1 ANK3 TGOLN2 ACTR10 SPARC STAB1 F5 STAB2 TRIP10 EXOC8 RAB9A EXOC7 RAB9B F8 TF USP6NL SCOC RABGEF1 EXOC4 GJA3 EXOC3 MIA3 TFG EXOC6 GJA5 EXOC5 GJA4 EXOC2 GJA9 GJA8 EXOC1 GABARAPL2 SYTL1 GAPVD1 BIN1 IGF2R AGTR1 IL7R HPR GABARAP GJC1 HPX GJC2 VTI1A RAB3IP STAM2 IGHA1 CD36 GBF1 IGHA2 CCZ1B RAB11A GJB4 GJB3 APOL1 GJB6 GJB5 GJB7 DENND1C DENND1B DENND1A STON1 STON2 SLC18A3 DENND2D DENND2C DENND2B IGHV3-23 DENND2A AP1S2 COPZ2 AP1S1 RAB3IL1 IGLV AP1S3 TACR1 IGLV2-8 IGKV1-16 EPS15L1 IGKV1-17 COPZ1 IGKV1-12 GJD2 IGHV3-7 GJD4 IGHV3-9 GJD3 VAMP4 V2-11 IGHV3-30 PAFAH1B3 ARF5 V3-4 SH3GL2 ARF6 V3-3 NBAS V2-17 NEDD8 TMF1 V3-2 IGHV3-33 USO1 GGA2 V2-15 ARFRP1 IGKV1D-39 GGA1 V2-19 GGA3 IGKV1D-33 LMAN2 STX6 IGKV2D-28 YWHAQ CHML IGKV4-1 RIC1 IGHV7-81 TRAPPC10 ARCN1 YWHAH SNX18 V1-11 GOLIM4 IGKV2D-30 RAB43 V1-16 RAB41 V1-13 SPTA1 RAB32 IGHV4-59 IGHV1-69 RINT1 RAB30 RAB36 RAB35 RAB38 IGLV2-11 YWHAZ ARL1 IGLV1-40 RAB3A IGLV1-47 RAB6B KIAA0319 IGLV6-57 IGLV2-14 TRAPPC2 ALS2 IGLV1-44 SEC16B TRAPPC3 IGKV3-15 TOR1A IGKV3-11 ANKRD27 V2-8 AMBP TRAPPC4 V1-20 SEC16A IGKV2D-40 IGHV3-11 HPS1 IGHV3-13 TRAPPC5 HPS4 IGKV1D-16 TRAPPC8 IGLV7-43 TRAPPC9 IGKV1D-12 TOR1B IGLV1-51 MAP1LC3B DAB2 IGLV2-23 CNIH1 AAK1 CNIH2 CNIH3 RAB31 MCFD2 IGKV3-20 IGHV4-34 BICD1 IGHV1-2 BICD2 IGHV1-46 RAB5B PPP6R1 RAB5C IGHV4-39 SGIP1 BET1L IGHV ARFGAP1 IGKV2-29 SEC22A IGKV2-28 RAB6A SEC22C IGLC3 RAB1A IGLC1 LRP1 IGLC2 AP1M2 V1-9 RAB1B V5-4 AP1M1 PPP6C DENND3 V1-7 LRP2 V5-1 PPP6R3 RAB21 TRAPPC1 V1-5 VPS51 FCHO1 V1-3 VPS53 COL1A1 IGKV3D-20 VPS52 V5-6 COL3A1 FCHO2 UBQLN1 COL1A2 VPS54 IGLV3-19 UBQLN2 COL4A2 AP1G1 NECAP2 IGKV2-30 IGHV2-70 SYT11 COL4A1 IGHV2-5 RAB12 FOLR1 IGLV3-1 IGHV3-48 BET1 IGLV3-25 KDELR1 COL7A1 IGLV3-27 GCC2 GCC1 IGKC GOLGA5 IGKV1-39 IGLV3-21 RINL GOLGA1 IGKV1-33 V4-6 ARFIP2 IGHV3-53 TBC1D10A V4-2 AGFG1 RAB10 TBC1D10B IGLC7 V4-1 COG8 COG7 IGKV5-2 COG6 IGKV1-5 LMAN1L IGLC6 COG5 RAB18 COG4 GJB2 COG3 GJB1 COG2 COG1 CHRM2 ANKRD28 PREB ULK1 RIN3 KDELR2 KDELR3 RIN1 RIN2 LMAN2L KIF3A GJA10 RAB39A ADRB2 RAB39B FTH1 RAB27B TBC1D10C SNAP91 MON1A MON1B HIP1 GDI1 AP1B1 MIA2 JCHAIN TMED3 TMED7 RAB8B TMED9 RAB33A RAB33B CLTB RAB7B NAPB RABGAP1 STX17 STX16 STX18 NAPG STX10 ALS2CL EPS15 RAB11B RGP1 SEC23IP RAB3GAP2 TRIP11 COPG2 COPG1 RAB3GAP1 SCARB2 SYS1 DENND5B TRAPPC12 TRAPPC11 DENND5A TRAPPC13 SH3GL1 TRAPPC2L TBC1D20 TBC1D24 CAPZA3 TBC1D25 DENND6B SYNJ1 AMPH DENND6A COPB2 COPA TMED10 MAN2A2 TBC1D13 PACSIN2 TBC1D14 COPB1 PACSIN3 TBC1D17 TBC1D15 TBC1D16 PACSIN1 SYT2 CD4 DENND4B DENND4A DENND4C CCZ1 SSC5D SYT9 SYT8 TMEM115 ALPP KIF28P COPE USE1 RABEPK SLC2A8 KIF5C MAN1A2 KIF5B MAN1A1 KIF5A NAA30 EPN1 KIF21A EPN2 KIF21B TBC1D2 COLEC12 APP KIFAP3 TRAPPC6A COLEC11 RABEP1 KIF16B TBC1D3 KIF20A TRAPPC6B KIF20B GORASP1 TBC1D7 NAA35 NAA38 GOSR2 GOSR1 COPS7B CYTH3 COPS7A CYTH2 KLC1 CYTH4 BNIP1 MAN1C1 COPS3 REPS2 KLC4 COPS6 CYTH1 KLC3 COPS5 REPS1 KLC2 COPS8 GALNT2 KIF3B KIF3C GOLGA4 KIF18A KIF18B KIF4B KIF4A RAB5A GALNT1 HBB KIF12 TSG101 VPS4B KIF11 VPS4A KIF15 MVB12B VAMP2 MVB12A VPS36 KIF19 CAPZB VTA1 VPS37C KIF13B SAA1 VPS37D KIF1C VPS37A SPTBN4 SNF8 KIF1B VPS37B SPTBN5 KIF1A CHMP2B CHMP4C KIF25 CHMP2A KIF23 CHMP4B KIF22 CHMP3 UBAP1 KIF6 CHMP4A HP KIF27 CHMP6 CHMP7 VPS25 KIF9 VPS28 KIFC2 CHMP5 SPTBN2 KIF2A KIFC1 KIF2C KIF2B SH3KBP1 CENPE KIF26A CAPZA1 KIF26B CAPZA2 VPS45 SEC22B SEC23A HGS SEC24B SEC24A SEC24D SEC24C CLTC CLTA RAC1 LDLRAP1 SEC31A MSR1 SURF4 SCARA5 MARCO SAR1B SCGB3A2 LDLR CTSZ CD3G CD3D SLC2A4 CD163 MYH9 CTSC DNM1 DNM2 DNM3 PIK3C2A APOE APOB APOA1 AREG ALB TGFA CD59 CD55 EPGN TJP1 GRK3 MASP1 HSPA8 ANK1 AVPR2 AP4E1 DCTN6 CLINT1 DCTN5 AP4M1 DCTN1 AP1G2 AP3S1 DCTN4 SH3D19 TPD52 GAK DNAJC6 MAN2A1 DNASE2 NAPA BLOC1S4 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 CLVS2 AP4S1 SNX9 SNX5 CLVS1 TBC1D8B SNAPIN SORT1 M6PR DTNBP1 HIP1R PUM1 TPD52L1 AP4B1 NECAP1 GOLGB1 YIPF6 ACBD3 AP2S1 AP2A1 SERPINA1 AP2B1 AP2A2 INS AP2M1 ARRB1 ARRB2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.2 Activation of NIMA Kinases NEK9, NEK6, NEK7 NEK9 NEK6 CDK1 NEK7 CCNB2 CCNB1 PLK1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 80%373076 Class A 1 (Rhodopsin-like receptors) CCL19 CCL22 CCL20 AVP TBXA2R FFAR3 GPR31 FFAR2 OPRD1 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C CXCR1 ADRB1 ADRA1D CXCR2 ADRB2 HTR2A HTR4 ADRA1B ADRA1A TAAR3P CXCL6 HTR6 CXCL9 CXCL13 HRH1 HTR7 CXCL3 HRH3 CXCL5 CX3CL1 HRH2 CXCL16 HRH4 PTGIR CCRL2 DRD1 CCR9 DRD2 CCR8 DRD3 CCR7 DRD4 CCR4 DRD5 TAAR8 CCR3 HTR1E XCL2 TAAR9 C5AR2 XCL1 C5AR1 HTR1F CX3CR1 TAAR6 CCL13 CXCR5 HTR1D CXCR6 HTR1A TAAR5 CCL7 CXCR3 HTR1B TAAR2 CCL1 CCL17 ADRA2C CCL16 HTR5A TAAR1 CCR10 CCL25 ADRA2B XCR1 ADRA2A CCL21 GPR143 ADRB3 CXCL11 CXCL8 ACKR4 ACKR3 ACKR2 CCL28 CXCL1 CCL27 CXCL2 OPRM1 S1PR1 C3 APP NPFFR2 NPFFR1 RXFP4 RRH GRPR RXFP3 HEBP1 EDNRA ANXA1 EDNRB MT-RNR2 OXER1 FPR1 PROK2 FPR3 PROK1 FPR2 OXTR CMKLR1 UTS2R AVPR1B NPFF OXT GPR37L1 C5 AVPR1A PDYN TRHR UTS2B KEL AGTR2 PTGFR LPAR1 LPAR2 LPAR3 LPAR4 NLN GALR3 GALR2 GALR1 NPBWR1 NPBWR2 CYSLTR1 PPY HCRT NTSR1 NTSR2 GPR17 NMB NMBR SAA1 LPAR5 LPAR6 NMS GPR183 NMU PNOC GNRH2 GNRH1 GPR18 PTGDR2 QRFP MLN BRS3 GPR132 CCKAR OPN1LW GNRHR OXGR1 C3AR1 EDN1 GPR37 EDN2 EDN3 GPR35 TACR2 TACR3 GAL OPN1MW CCKBR RGR NPB PLPPR1 PLPPR2 PTGER1 PLPPR3 PLPPR4 PTGER3 PLPPR5 PROKR1 CXCL10 PROKR2 NPW KISS1R PRLH P2RY12 P2RY13 P2RY10 P2RY14 PTAFR GPR55 GPR4 AGT CCL5 XK F2RL1 CCL4 F2RL2 CCL3 F2RL3 CCL2 GPR68 GPR65 PMCH NPY2R ADORA3 ADORA1 GHSR CXCR4 NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 NTS MCHR2 HCAR2 HCAR3 HCAR1 TAC3 TAC1 OPN4 OPN3 OPN5 PYY NMUR2 NMUR1 MLNR ECE1 ECE2 TRH LTB4R BDKRB2 BDKRB1 CCR1 PRLHR QRFPR INSL5 NPY5R GNRHR2 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 P2RY6 CNR2 P2RY4 CNR1 P2RY2 P2RY1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HCRTR2 HCRTR1 APLN KISS1 OPN1SW CCR6 ACKR1 CCR5 CCR2 SST RXFP1 RXFP2 CYSLTR2 PTGDR LHCGR GRP LHB FFAR4 FFAR1 CXCL12 PPBP MC2R CGA PSAP MC1R RLN2 RLN3 CCL3L3 MC4R GPER1 INSL3 TSHB GPR39 FSHB KNG1 AVPR2 GPBAR1 MC3R ADORA2A ADORA2B FSHR PTGER4 F2R NPSR1 F2 PENK PTGER2 SSTR3 NPS GPHA2 P2RY11 PF4 TSHR POMC MC5R AGTR1 GPHB5 MCHR1 RHO NPY TACR1 CCL11 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 80%8986944 Transcriptional Regulation by MECP2 SST HIPK2 CAMK2B GRIA2 MOV10 MET CAMK2D HDAC2 CAMK2A PPARG SLC2A3 GRIN2B FKBP5 GRIN2A OPRM1 CALM1 CAMK2G IRAK1 AGO3 PTPN4 AGO4 AGO1 AGO2 AURKB DLL1 PTEN PRKACA PTPN1 TNRC6C TRPC3 NCOR2 TNRC6A HDAC3 NCOR1 TNRC6B TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X CRH LBR CREB1 SOX2 OPRK1 DGCR8 GAMT RBFOX1 GPRIN1 PVALB BDNF HTT MOBP GAD1 GAD2 FOXG1 SGK1 MEF2C FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 80%163210 Formation of ATP by chemiosmotic coupling ATP5PO ATP5MG ATP5MF ATP5ME ATP5F1A ATP5F1B ATP5MC1 DMAC2L ATP5PF ATP5PD ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATP5F1D ATP5F1E MT-ATP8 MT-ATP6 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 80%2206282 MPS IIIB - Sanfilippo syndrome B NAGLU ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 80%1566948 Elastic fibre formation FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 LTBP2 FBLN1 LTBP3 FBLN2 LTBP1 LOXL1 ITGB8 FBLN5 LOXL2 ITGB6 EFEMP2 TGFB2 EFEMP1 TGFB3 BMP7 GDF5 BMP4 MFAP5 ITGB5 MFAP4 ITGA8 LOX MFAP1 MFAP3 FBN1 MFAP2 BMP2 VTN ITGAV ITGA5 ITGB3 TGFB1 FURIN ITGB1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190242.2 FGFR1 ligand binding and activation FGF22 FGF10 FGF1 FGF2 FGF3 FGF4 FGF6 ANOS1 FGF9 FGF20 FGF23 DSCAM INTERACTIONS%REACTOME%R-HSA-376172.1 DSCAM interactions NTN1 MAPK8 DSCAML1 PAK1 MAPK14 RAC1 MAPK11 MAPK12 DSCAM MAPK13 DCC MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME%R-HSA-427601.2 Multifunctional anion exchangers SLC26A3 SLC26A6 SLC5A12 SLC26A11 SLC26A2 SLC26A7 SLC26A1 SLC26A9 SLC26A4 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 80%3359478 Defective MUT causes MMAM MMUT MMAA SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.1 Signaling by kinase domain mutants of KIT KIT DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME DATABASE ID RELEASE 80%5619061 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 80%196849 Metabolism of water-soluble vitamins and cofactors TCN1 SLC2A1 NNMT ABCC1 LRP2 GSTO2 DHFR LDLRAP1 CUBN AMN PRSS1 MTRR MMAA MMAB MTR MMUT MMACHC MMADHC CTRB2 CTRB1 BST1 FOLR2 SLC2A3 NAPRT SLC23A2 SLC46A1 ALDH1L1 DHFR2 SLC23A1 NADSYN1 ALDH1L2 FLAD1 NUDT12 MTHFD1 MTHFD2 MTHFD2L PNPO NADK SLC19A1 CBLIF SLC52A2 SLC52A3 MTHFR SLC5A8 SLC52A1 PC BTD MTHFS TCN2 PCCA HLCS CD320 ABCD4 PCCB ACACB MOCS2 ACACA MOCS3 QPRT GPHN NADK2 SLC22A13 NMRK2 RFK NMRK1 ACP5 CD38 AOX1 LMBRD1 NAXE PDXK MTHFD1L CYB5A NAMPT RNLS MOCOS NMNAT3 NMNAT2 NMNAT1 SLC25A32 PANK4 NAXD PANK2 THTPA PANK3 TPK1 PANK1 SLC25A19 SLC19A3 COASY SLC19A2 PPCDC SLC5A6 SLC25A16 VNN1 VNN2 SHMT1 PPCS PDZD11 FASN ENPP2 ENPP1 PTGIS ENPP3 CYP8B1 AASDHPPT PARP10 PARP6 MCCC2 PARP4 PARP16 PARP9 MCCC1 PARP14 SHMT2 PARP8 CYB5R3 GSTO1 PTGS2 PRSS3 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 80%141334 PAOs oxidise polyamines to amines PAOX SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.4 Signaling by SCF-KIT PRKCA LCK GRB7 PTPRU FYN RAC1 STAT1 FER GRAP PIK3R3 GAB2 PIK3R1 VAV1 CBL NRAS PIK3CA SOS1 SH2B3 HRAS SOCS1 SH2B2 SOCS6 GRAP2 GRB10 MMP9 YES1 PTPN6 STAT3 FES PIK3R2 LYN CHEK1 STAT5A TEC STAT5B KIT PTPN11 CMA1 JAK2 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 80%5624138 Trafficking of myristoylated proteins to the cilium ARL3 CYS1 NPHP3 RP2 UNC119B CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.2 Cell Cycle Checkpoints HERC2 PIAS4 SEC13 NUP133 YWHAQ RNF168 YWHAH BLM NUP160 YWHAZ MRE11 WRN NUP85 GTSE1 NUP43 PKMYT1 RANBP2 AURKB UBE2N CDKN2A BUB1 CLASP2 RPS27 RPA1 NUP37 CDC7 UBE2V2 CCNA2 CCNA1 MCM10 DBF4 DNA2 NSD2 H3-4 PPP2R5E PPP2R5B PPP2R5A PPP2R5C RFC5 RFC3 RFC4 TP53 RFC2 RPA2 YWHAE RPA3 PPP2R1A YWHAG BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 TOP3A RAD50 DYNLL1 CKAP5 MAPRE1 UBA52 PAFAH1B1 DYNC1I2 CCNB2 HUS1 DYNC1LI1 CCNB1 DYNC1LI2 UBB KIF18A UBC RHNO1 CDCA8 RPS27A ATRIP CLASP1 SKA1 SKA2 DYNC1H1 NDE1 RAD17 SFN PLK1 ATR CDK1 CDC45 MCM7 MCM8 NUF2 CDKN1A NUDC MCM3 ANAPC15 MCM4 CDKN1B MCM5 ANAPC16 DYNLL2 MCM6 ANAPC10 MCM2 ANAPC11 PSMD8 INCENP PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 KIF2A PSMD3 PSMD1 KIF2C KIF2B RAD1 ANAPC7 YWHAB PSMA5 UBE2C PSMA6 PSMA3 UBE2E1 PSMA4 PSMA1 PSMA2 CCNE2 PSME3 PSME4 UBE2S PSME1 PSME2 CCNE1 CDC16 CENPE PSMD10 CDK2 CENPF ANAPC4 PSMB11 WEE1 TAOK1 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB PSMB10 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PHF20 PSMB9 CHEK2 CDC25C SEM1 ZNF385A PSMC5 COP1 RAD9B PCBP4 PSMC6 RAD9A PSMC3 CLIP1 MDM2 PSMC4 MDM4 ATM PSMC1 PSMC2 MAD1L1 BABAM1 TOPBP1 BABAM2 UIMC1 ABRAXAS1 RNF8 BRCC3 TP53BP1 NDC80 ORC5 SPDL1 ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 CHEK1 CDC25A ZW10 DSN1 RCC2 ZWINT AHCTF1 CLSPN XPO1 NDEL1 PPP2R5D PPP2R1B MIS12 H2AX DYNC1I1 H2BC12L H2BC21 H2BU1 B9D2 KNL1 SPC24 SPC25 H2BC17 ERCC6L H2BC12 H2BC13 H2BC14 ZWILCH H2BC15 H2BC11 ITGB3BP CENPA CENPC KNTC1 H2BC9 CENPT CENPU SGO1 H4C9 H2BC8 SGO2 H2BC5 H2BC3 H2BC1 CENPH PMF1 CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ MDC1 CENPS NUP107 UBE2D1 BRCA1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.2 Drug resistance of PDGFR mutants PDGFRA REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.3 Replication of the SARS-CoV-1 genome VHL DDX5 ZCRB1 RB1 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 80%9683683 Maturation of protein E RPS27A UBB UBA52 UBC PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 80%5693607 Processing of DNA double-strand break ends HERC2 SUMO2 RNF4 PIAS4 RAD1 RNF168 RFC5 RFC3 CDK2 RFC4 CLSPN BLM RFC2 RPA2 MRE11 WRN RPA3 UBE2N RAD9B RAD9A BRIP1 KAT5 UBE2I RPA1 EXO1 ATM RBBP8 NBN BARD1 BABAM1 TOPBP1 RMI2 BABAM2 RMI1 UIMC1 TOP3A ABRAXAS1 RNF8 BRCC3 RAD50 TP53BP1 H2AX CCNA2 UBE2V2 SIRT6 CCNA1 H2BC12L PPP4R2 H2BC21 TIPIN UBA52 TIMELESS PPP4C H2BU1 DNA2 H2BC17 H2BC12 H2BC13 H2BC14 HUS1 H2BC15 H2BC11 NSD2 UBB UBC RHNO1 H2BC9 RPS27A ATRIP H4C9 H2BC8 H2BC5 H3-4 H2BC3 RAD17 CHEK1 H2BC1 ATR MDC1 BRCA1 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 80%6782315 tRNA modification in the nucleus and cytosol EPRS1 URM1 WDR4 THADA LAGE3 TP53RK OSGEP ALKBH8 THG1L TYW1 LCMT2 TRMT44 TRDMT1 TRMT112 PUS3 TRMT10A TYW5 METTL1 NSUN2 TYW3 TPRKB ADAT1 CDKAL1 TRMT1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 ADAT2 QTRT1 DUS2 TRMT9B CTU2 QTRT2 CTU1 TRMT5 TRMT6 TRMT12 TRMT13 TRMT11 TRMT61A AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.6 Amyloid fiber formation TSPAN15 NAT8 TGFBI ITM2B APOA1 APOA4 SIAH2 GGA2 SIAH1 GGA1 GGA3 LTF H3C15 CST3 CALCA GSN USP9X IAPP FURIN B2M APP FGA H2AX H3-3B H2AB1 UBE2L6 H2AC19 H2AC14 SEMG1 H2BC12L H2BC21 UBA52 PRKN H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 TTR H2BC14 H2BC15 H2BC11 UBB UBC H2AZ1 H2BC9 RPS27A MFGE8 H4C9 H2BC8 LYZ APH1A PSENEN APH1B H2BC5 ADAM10 H2BC3 HSPG2 H2BC1 INS H2AC20 TSPAN14 CALB1 SAA1 NAT8B BACE1 PRL APCS TSPAN33 H3C8 TSPAN5 NCSTN SNCA NPPA ODAM APOE SNCAIP SORL1 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 80%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 80%189085 Digestion of dietary carbohydrate CHIT1 CHIA AMY2A AMY1A AMY2B AMY1B SI MGAM TREH AMY1C LCT FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.1 FLT3 signaling through SRC family kinases FLT3 LCK FYN FLT3LG HCK SYK TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RBL2 RBL1 E2F4 GADD45A SFN CDC25C CARM1 PCNA ZNF385A TFDP1 CDK1 TFDP2 EP300 AURKA CCNB1 TP53 PRMT1 BAX UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 80%5339562 Uptake and actions of bacterial toxins HSP90AB1 SV2C SV2B SV2A VAMP1 TXNRD1 STX1B GUCY2C PDZD3 CD9 SNAP25 PDCD6IP STX1A MAP2K4 MAP2K7 HBEGF CALM1 MAP2K1 SYT2 SYT1 EEF2 FURIN VAMP2 HSP90AA1 MAP2K2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 80%3270619 IRF3-mediated induction of type I IFN PRKDC IFI16 TREX1 XRCC6 XRCC5 NLRC3 NLRP4 DTX4 TBK1 IRF3 STING1 DDX41 MRE11 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 80%71032 Propionyl-CoA catabolism MCEE PCCB MMUT MMAA PCCA PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%R-HSA-1912422.1 Pre-NOTCH Expression and Processing ST3GAL6 CCND1 LFNG E2F1 E2F3 CREBBP MOV10 NOTCH1 MAML2 MAML1 H3C15 RBPJ TFDP1 KAT2B KAT2A TFDP2 SNW1 EP300 MAML3 MAMLD1 JUN TP53 AGO3 AGO4 AGO1 AGO2 RUNX1 FURIN TNRC6C RAB6A TNRC6A TNRC6B H2AX H3-3B H2AB1 H2AC19 H2AC14 SIRT6 H2BC12L ELF3 NOTCH2 H2BC21 NOTCH3 NOTCH4 H2BU1 H2AC8 H2AC6 H2AC7 ST3GAL4 SEL1L H2BC17 H2BC12 H2BC13 H2BC14 TMED2 H2AJ ST3GAL3 H2BC15 RFNG POGLUT1 H2BC11 POFUT1 MFNG H2AZ1 H2BC9 PRKCI H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 B4GALT1 H2BC1 ATP2A3 ATP2A2 ATP2A1 H2AC20 H3C8 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 80%1630316 Glycosaminoglycan metabolism ABCC5 HPSE2 SLC35B3 XYLT2 SLC35B2 XYLT1 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 NDST1 NAGLU NDST4 CHPF NDST3 CHP1 IDS CSGALNACT1 GUSB CSGALNACT2 HS3ST3B1 GLCE CEMIP CHST11 B4GALT7 HS3ST3A1 CHST12 DSEL IDUA CHST15 B3GAT3 CHST13 B3GAT2 UST B3GAT1 B4GALT2 HS3ST5 B4GALT3 HS3ST6 HYAL1 HS3ST4 HYAL2 HS3ST1 HYAL3 HS3ST2 EXT1 DSE EXT2 CHST7 HPSE CHPF2 B3GNT7 B3GNT4 B3GNT3 CHST1 B3GNT2 HMMR B4GALT6 CHST5 B4GALT4 CHST2 B4GALT5 HAS1 HAS3 HAS2 CHSY3 LYVE1 PAPSS1 CHST3 PAPSS2 SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 GPC5 CSPG4 GPC4 AGRN GPC6 HSPG2 BCAN HEXB HEXA ST3GAL6 B4GAT1 SLC9A1 DCN SLC26A2 CD44 SLC26A1 ARSB ACAN CHST14 GLB1L CHSY1 GLB1 STAB2 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 GNS CHST6 LUM OGN OMD KERA PRELP FMOD B4GALT1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 80%425407 SLC-mediated transmembrane transport SLC30A5 SLC11A2 SLC39A10 SLC30A1 SLC39A14 SLC35B3 SLC35B2 LCN9 SLC27A1 SLC35B4 SLC35D1 SLC35D2 SLCO1B1 LCN15 SLCO2B1 LCN12 SLCO1B3 APOD SLC16A2 SLC35A2 SLC35A1 SLC35A3 SLC33A1 SLC35C1 SLCO1C1 ARL2BP SLCO4A1 SLC2A9 SLCO2A1 CALM1 SLCO1A2 SLCO4C1 LCN1 SLC29A4 SLC27A6 AVP SLC25A5 SLC28A2 SLC29A1 SLC28A1 SLC15A4 SLC25A4 SLC29A3 SLC25A6 SLC29A2 SLC28A3 SLC27A4 SLC2A10 SLC5A7 SLC5A9 SLC45A3 SLC5A1 SLC5A3 SLC5A4 SLC10A6 SLC4A7 SLC2A14 SLC2A11 SLC2A13 SLC2A12 MFSD4B SLC11A1 SLC14A1 SLC14A2 SLC2A6 SLC2A7 SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC47A2 SLC47A1 SLC5A11 SLC5A10 SLC13A5 SLC50A1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC8A1 SLC8A2 SRI SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC5A2 SLC9A6 SLC9A7 SLC9A8 SLC2A3 SLC9A9 SLC9A1 SLC16A7 SLC16A8 EMB SLC16A3 SLC8A3 AHCYL2 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC6A19 SLC26A11 SLC12A6 SLC6A18 SLC12A7 SLC6A15 SLC22A2 SLC38A1 SLC22A1 SLC15A1 SLC6A14 SLC15A2 SLC6A13 SLC5A8 SLC6A12 SLC26A2 SLC6A11 SLC26A1 SLC6A20 SLC1A1 SLC6A1 SLC1A2 SLC6A2 SLC1A3 SLC6A3 SLC1A4 SLC6A5 SLC1A6 SLC6A6 SLC1A7 SLC5A5 SLC6A7 SLC6A9 SLC38A3 SLC18A1 SLC15A3 SLC2A8 SLC18A2 SLC38A2 SLC38A5 SLC38A4 SLC4A10 SLC16A10 SLC26A7 SLC26A9 SLC26A4 SLC26A3 SLC26A6 SLC7A11 SLC7A10 SLC32A1 SLC7A5 SLC7A6 SLC7A9 SLC25A18 SLC7A7 SLC3A1 SLC7A8 SLC25A10 SLC24A2 SLC24A1 SLC5A6 SLC24A4 SLC24A3 SLC43A2 SLC20A2 SLC20A1 SLC43A1 PDZD11 SLC5A12 SLC3A2 SLC7A1 SLC7A3 SLC25A26 SLC25A29 SLC17A6 SLC17A7 SLC17A8 SLC17A1 SLC36A4 SLC25A22 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 CTNS SLC4A8 SLC4A9 SLC24A5 SLC40A1 CP SLC22A7 SLC2A1 SLC16A1 RUNX1 SLC22A3 SLC36A1 SLC36A2 SLC8B1 BSG SLC1A5 SLC2A2 SLC2A4 SLC17A5 FGF21 RHAG SLC4A1 SLC34A3 SLC34A2 SLC34A1 ARL2 RHCG RHBG SLC22A18 SLC22A4 RSC1A1 SLC22A6 SLC22A5 SLC22A12 SLC22A15 SLC22A16 SLC22A8 SLC22A11 SLC41A2 SLC41A1 SLC30A10 HEPH SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC31A1 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 80%3781860 Diseases associated with N-glycosylation of proteins NEU1 MAN1B1 ALG11 B4GALT1 DPAGT1 CTSA ALG8 ALG9 ALG6 MGAT2 ALG14 ALG2 ALG13 ALG3 ALG12 ALG1 MOGS MPDU1 RFT1 GLB1 MMR%REACTOME%R-HSA-5358508.1 MMR RPA3 MLH1 MSH6 PCNA POLD3 POLD4 MSH3 POLD1 RPA1 POLD2 EXO1 MSH2 LIG1 RPA2 PMS2 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 80%8948747 Regulation of PTEN localization RPS27A XIAP PML USP7 UBB UBA52 NEDD4 PTEN UBC TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 80%937061 TRIF(TICAM1)-mediated TLR4 signaling IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 TICAM2 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 MAPK3 PPP2R1A LY96 CD14 DUSP4 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N TLR4 MAPK7 TAB3 PPP2R1B TAB2 SKP1 TAB1 FBXW11 NFKBIB TBK1 MAPK11 APP UBE2D3 HMGB1 TRAF6 CASP8 UBA52 NKIRAS1 NKIRAS2 IKBKE TICAM1 CUL1 ELK1 CREB1 UBB IRF3 TRAF3 MAP2K1 IRF7 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER TANK S100A12 RIPK1 FADD RIPK3 S100B NFKB2 SAA1 PTPN11 UBE2D2 ATF2 UBE2D1 MEF2A BIRC2 MEF2C BIRC3 RPS6KA3 RPS6KA5 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.2 Leukotriene receptors GPR17 LTB4R2 LTB4R CYSLTR1 CYSLTR2 RORA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1368082.3 RORA activates gene expression TBL1XR1 SREBF1 HELZ2 CPT1A TBL1X NCOA2 CHD9 NCOA1 CREBBP NCOA6 SMARCD3 CARM1 PPARA EP300 RXRA MED1 RORA TGS1 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.2 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.3 Peptide hormone metabolism SLC30A5 BCHE ANPEP PAX6 GNAT3 CPB2 CTSG PCSK1 CDX2 GRP CTSD GPR119 DPP4 SPCS3 LHB SPCS2 SPCS1 FFAR4 FFAR1 RAB27A ERO1A CRHR2 SEC11A TCF7L2 MYO5A SEC11C CTNNB1 CGA INHBB AGT INHBA INHA INHBC INHBE ACE2 GNG13 GNB1 GNB3 KIF5C TSHB KIF5B CGB8 KIF5A CMA1 FSHB GIP ISL1 GATA4 PCSK2 UCN ERO1B CPA3 EXOC8 STX1A EXOC7 MYRIP AOPEP ENPEP CPB1 PLA2G7 CLTRN ACE EXOC4 IGF1 EXOC3 GCG MBOAT4 EXOC6 GZMH ACHE EXOC5 POMC CPE EXOC2 REN EXOC1 KLF4 CTSZ LEP ATP6AP2 INS VAMP2 MME SLC30A7 SLC30A6 CES1 SLC30A8 GH1 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.2 Defective GCLC causes HAGGSD GCLC GCLM REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.2 Rev-mediated nuclear export of HIV RNA RANBP1 NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 XPO1 RANGAP1 POM121C NUP42 NUP85 TPR RCC1 NUP88 NUP43 RAN RAE1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.1 Synthesis and processing of ENV and VPU FURIN ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 80%2214320 Anchoring fibril formation BMP1 COL7A1 LAMA3 TLL2 TLL1 LAMC2 LAMB3 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 80%2046105 Linoleic acid (LA) metabolism FADS2 ELOVL1 ACSL1 ELOVL5 ELOVL2 ELOVL3 ABCD1 FADS1 PD-1 SIGNALING%REACTOME%R-HSA-389948.2 PD-1 signaling HLA-DPB1 CD274 LCK HLA-DQA2 HLA-DQA1 PDCD1LG2 HLA-DRB5 HLA-DRB4 TRBC1 HLA-DQB2 HLA-DQB1 TRBV12-3 TRBV7-9 TRAV19 HLA-DRB3 HLA-DRB1 HLA-DRA CD3G TRAC PTPN6 CD3E CD3D CD4 TRAV8-4 HLA-DPA1 CSK PTPN11 PDCD1 TRAV29DV5 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.3 Mitochondrial transcription initiation TFAM TFB2M POLRMT BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.1 Beta-catenin phosphorylation cascade PPP2CA PPP2CB FRAT1 AMER1 FRAT2 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 80%70688 Proline catabolism ALDH4A1 PRODH PRODH2 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.2 Classical Kir channels KCNJ14 KCNJ2 KCNJ4 KCNJ12 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.2 Regulation of FZD by ubiquitination RPS27A LRP5 LRP6 ZNRF3 UBA52 FZD8 RSPO2 WNT3A RSPO3 RSPO1 RSPO4 LGR6 LGR5 FZD5 LGR4 USP8 UBB RNF43 FZD4 FZD6 UBC THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.1 The IPAF inflammasome CASP1 NLRC4 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 80%9674396 Imatinib-resistant PDGFR mutants PDGFRA AUTOPHAGY%REACTOME%R-HSA-9612973.2 Autophagy UBAP1 ATG14 CHMP4A CHMP6 CHMP7 VPS28 PLIN3 SQSTM1 PRKAA1 PRKAA2 ATG7 PRKAG1 PRKAG2 PRKAG3 EEF1A1 RPTOR MFN1 MFN2 UBE2V1 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMP2 LAMTOR4 MAP1LC3B LAMTOR3 LAMTOR5 CSNK2A1 UBE2N CSNK2A2 ATM CSNK2B MTMR14 MTMR3 PRKN VCP VDAC1 TOMM20 TOMM22 PARK7 GABARAPL3 IFT88 ATG3 ULK1 PIK3C3 GABARAPL1 ATG9B ATG9A ATG10 ATG13 RNASE1 ATG101 BECN1 MTERF3 GFAP ARL13B ATG16L1 CETN1 WDR45 MAP1LC3A MAP1LC3C FUNDC1 RB1CC1 USP30 WIPI1 WIPI2 PEX5 ATG4C ATG4B ATG4A ATG4D WDR45B AMBRA1 NBR1 CFTR PIK3R4 HDAC6 TOMM40 HSF1 HSPA8 TOMM7 HSP90AA1 TOMM5 TOMM6 UVRAG HSP90AB1 DYNLL1 PLIN2 DYNC1I1 UBA52 TOMM70 DYNC1I2 EPAS1 ATG12 DYNC1LI1 DYNC1LI2 UBB GABARAPL2 UBC RPS27A PCNT GABARAP DYNC1H1 ATG5 HBB TSG101 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B CHMP2B CHMP4C PINK1 CHMP2A CHMP4B DYNLL2 CHMP3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 80%2179392 EGFR Transactivation by Gastrin MMP3 PRKCA SOS1 HRAS HBEGF EGFR NRAS RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 80%195258 RHO GTPase Effectors DIAPH1 SEC13 NUP133 YWHAQ YWHAH DLG4 CALM1 NUP160 YWHAZ NUP85 NUP43 RANBP2 AURKB BUB1 CLASP2 RPS27 KDM4C LIMK2 LIMK1 ROCK1 FMNL3 MAPK11 FMNL1 FMNL2 NUP37 H3-3B PDPK1 KTN1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C MAPK14 YWHAE PPP1CB PPP2R1A YWHAG KDM1A PPP1R12A KIF5B KIF5A CYFIP2 DYNLL1 WIPF1 CKAP5 WIPF2 WIPF3 KLC1 MYLK MAPRE1 KLC4 KLC3 KLC2 PAFAH1B1 DYNC1I2 ABL1 PRKCD MRTFA AR DYNC1LI1 DYNC1LI2 MYL6 DAAM1 KIF18A MYL9 CDCA8 IQGAP1 IQGAP2 PRKCZ CLASP1 IQGAP3 SKA1 SKA2 DYNC1H1 NDE1 SFN PLK1 ARPC1B ARPC1A PIN1 NUF2 H3C8 NUDC CDKN1B DYNLL2 CIT INCENP PRKCA KIF2A PKN3 KIF2C KIF2B PRKCB YWHAB FLNA H3C15 CENPE CENPF TAOK1 PKN2 GOPC PPP2CA PKN1 PPP2CB MAPK1 CTNNB1 MAPK3 PPP1CC CFL1 MEN1 CDC25C CLIP1 ITGB1 NCKAP1 CYFIP1 MAD1L1 NCF1 LIN7B NCF2 NCF4 DVL1 BRK1 DVL2 DVL3 CDC42 PAK1 ARPC4 ARPC5 NDC80 RAC1 PAK3 ARPC2 PAK2 ARPC3 NF2 CYBB CYBA SPDL1 NCK1 ACTR3 ACTR2 CDH1 RANGAP1 BIRC5 RHOA NOXO1 PIK3C3 BUB1B EVL CDC20 PPP1R12B BUB3 MAD2L1 ROCK2 SRF NSL1 MYH9 NCKAP1L WASF3 WASF1 SRGAP2 PPP1R14A WASF2 KLK2 PRC1 BAIAP2 ZW10 BTK PFN1 DIAPH3 CFTR ROPN1 ABI2 PFN2 ABI1 NOXA1 NOX3 PIK3R4 NOX1 KLK3 MYL12B S100A9 DSN1 S100A8 ACTB SCAI RCC2 ZWINT PTK2 AHCTF1 KIF14 WASL XPO1 RAC2 NDEL1 NCOA2 RHOG RHOC RHOD RHOB PPP2R5D CTTN PPP2R1B TAX1BP3 RHOQ MIS12 WAS H2AX CTNNA1 H2AB1 H2AC19 DYNC1I1 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 B9D2 H2AC6 H2AC7 KNL1 SPC24 SPC25 H2BC17 ERCC6L H2BC12 H2BC13 RTKN H2BC14 H2AJ ZWILCH H2BC15 H2BC11 ACTG1 ITGB3BP CENPA CENPC KNTC1 H2AZ1 H2BC9 CENPT H2AZ2 CENPU SGO1 H4C9 H2BC8 SGO2 H2BC5 H2BC3 H2BC1 CENPH PMF1 CENPI H2AC20 CENPK NCKIPSD CENPL CENPM CENPN RHPN1 CENPO MYH14 CENPP MYH11 CENPQ RHPN2 CENPS NUP107 MYH10 PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.10 PI3K AKT Signaling INSR BMI1 RING1 SRC NRG1 RNF2 HDAC7 CBX8 PHC2 PHC1 CSNK2A1 CBX4 CSNK2A2 CBX2 PHC3 PML CSNK2B PDPK1 TRAF6 BTC NRG3 NRG4 NRG2 HBEGF EREG PPP2R5E GSK3B PPP2R5B PPP2R5A ATF2 PPP2R5C PIP4K2A PIP4K2B TRIM27 PIP4K2C IER3 TRIB3 FLT3 MAPKAP1 GSK3A PIP5K1A BAD PIP5K1B CASP9 PIP5K1C MKRN1 AKT3 EGR1 MOV10 SNAI1 SNAI2 EZH2 MECOM KLB PPARG PHLPP2 PHLPP1 XIAP RICTOR MBD3 SUZ12 GATAD2B JUN IL33 GATAD2A RNF146 IL1RL1 TP53 NEDD4 FRK ATN1 SALL4 MAF1 TNKS IRS2 FOXO6 IRAK1 FGF19 FOXO4 AGO3 FOXO1 FGFR4 AGO4 THEM4 PPP2R1A AGO1 CBX6 AGO2 NR4A1 MYD88 PRR5 PTEN CHD4 CHD3 NR2E1 EED IRAK4 USP13 KDM1A HDAC5 MTA1 TNKS2 MTA2 MTA3 TNRC6C REST RPS6KB2 STUB1 TNRC6A OTUD3 TNRC6B PREX2 UBA52 FRS2 FGF1 FGF2 FGF3 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 FGF22 FGF10 RPS27A RCOR1 PTPN11 CDKN1A CDKN1B PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 CHUK PSMA5 PSMA6 HDAC2 PSMA3 RPTOR PSMA4 PSMA1 PSMA2 AKT2 PSME3 PSME4 WWP2 MLST8 PSME1 AKT1 PSME2 SLC38A9 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 TSC2 PSMA7 PPP2CA PPP2CB MTOR PSMB10 MAPK1 PSMA8 RRAGA PSMB6 MAPK3 RRAGC PSMB7 PSMB4 PSMB5 RHEB RRAGB PSMB2 PSMB3 AKT1S1 RRAGD PSMB1 PSMF1 LAMTOR2 LAMTOR1 PSMB8 LAMTOR4 PSMB9 LAMTOR3 LAMTOR5 SEM1 PSMC5 PSMC6 PSMC3 MDM2 PSMC4 PSMC1 KIT PSMC2 HDAC3 CD86 HDAC1 LCK CD80 CD28 FYN RAC1 EGF GAB1 PIK3R1 VAV1 EGFR PIK3CA PIK3R2 IRS1 PIK3CD PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG PIK3R3 GAB2 MET PDGFB TGFA CD19 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 USP7 RAC2 RHOG FGF16 FGF7 FGF18 PPP2R5D PPP2R1B FOXO3 CREB1 RBBP4 RBBP7 ERBB2 INS ARACHIDONIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 80%2142753 Arachidonic acid metabolism FAAH CYP4A22 CBR1 CYP4A11 GGT5 FAAH2 PTGR1 PTGR2 CYP2U1 DPEP2 DPEP1 CYP2C9 DPEP3 CYP2C8 PTGES HPGD PON2 LTA4H ALOX12B MAPKAPK2 CYP4F22 ALOXE3 CYP2J2 CYP4F2 CYP4F3 CYP4B1 CYP4F8 PON3 PTGES2 CYP4F11 PRXL2B PON1 ALOX5AP LTC4S TBXAS1 CYP1A1 ALOX5 ALOX15 PTGS1 HPGDS CYP1B1 PTGES3 ABCC1 GPX1 ALOX12 GPX2 CYP1A2 GPX4 ALOX15B AWAT1 PTGIS CYP8B1 AKR1C3 PTGDS PLA2G4A GGT1 PTGS2 EPHX2 CYP2C19 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.5 GABA receptor activation ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 GABRB3 GABRB2 GABRB1 GABRR3 GABRR2 GABRR1 NPTN GNAL GABRG3 GABRG2 GABRA2 GABRQ GABRA1 GNG10 GABRA6 GABRA5 GABRA4 GABRA3 GNG12 GNG11 ARHGEF9 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCY9 KCNJ2 KCNJ3 KCNJ4 GABBR2 KCNJ5 GABBR1 KCNJ10 KCNJ12 KCNJ9 KCNJ15 KCNJ16 ADCY4 NEURONAL SYSTEM%REACTOME%R-HSA-112316.7 Neuronal System GJD2 CAMK2B GRIA1 GRIA2 CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2C GRIN2B GRIN1 FLOT1 NRGN GRIN2D GRIN2A DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G RAB3A KCNAB2 SHANK3 SLC5A7 FLOT2 PLCB3 CHAT PLCB1 PLCB2 MAOA PDPK1 DNAJC5 ACHE PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A GJA10 PRKAR2A KCNMA1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 BCHE KCNMB1 KCNMB2 KCNMB3 KCNMB4 PRKX CAMKK1 CAMKK2 KCNK6 KCNK7 KCNK9 KCNK16 KCNK17 GABRB3 KCNK18 GABRB2 GABRB1 KCNK1 GABRR3 KCNK3 GABRR2 GABRR1 KPNA2 GNAL NPTN GABRG3 GABRG2 CACNB1 GABRA2 CACNB2 GABRQ CACNB3 GABRA1 CACNB4 GABRA6 KCNK13 SLC22A2 GABRA5 SLC38A1 SLC22A1 GABRA4 SYT2 GABRA3 NBEA ABAT SLC6A13 ARL6IP5 SLC6A12 HOMER3 PRKACA SLC6A11 CACNA2D1 SLC1A1 CACNA2D3 SLC6A1 SLC1A2 SYT9 EPB41 SLC1A3 STXBP1 SLC6A3 EPB41L5 SLC1A6 EPB41L2 SLC1A7 HOMER1 HOMER2 PPFIBP1 PPFIBP2 SLC18A2 SLC38A2 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 PANX2 RTN3 PTPRS SIPA1L1 PTPRF DLGAP1 DLGAP3 LRFN3 DLGAP2 PTPRD DLGAP4 LRFN2 SLC32A1 ALDH5A1 LRFN4 BEGAIN LRFN1 GLRA1 GLRA2 GLRA3 APBA3 APBA2 NAAA CHRNA7 CACNA1B CACNA1A CACNA1E LRRC4B SYT7 LRRTM3 LRRTM4 CACNG8 LRRTM1 LRRTM2 CACNA2D2 HTR3E GLS HTR3C HTR3D CACNG2 HTR3A CACNG3 SLC17A7 HTR3B CACNG4 IL1RAPL2 SHANK2 PRKAR2B SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 NCALD RPS6KA6 SLITRK2 SLITRK1 SLITRK4 SLITRK6 PDLIM5 NLGN4Y MYO6 NLGN4X SHARPIN SYT12 GLRB COMT SYT10 VAMP2 RPS6KA3 RPS6KA2 NSF RPS6KA1 PRKCG PRKCA GRIP2 GRIP1 TSPAN7 PICK1 GRIA3 GRIA4 PRKAA1 PRKAA2 PRKCB GRM5 PRKAG1 ALDH2 PRKAG2 TOMT PRKAG3 SLC6A4 IL1RAPL1 PRKAB2 KCNQ4 PANX1 PRKAB1 EPB41L1 EPB41L3 MAPK1 MAPK3 KCNJ8 KCNJ11 ABCC8 ABCC9 KCNK10 KCNK2 KCNK4 AKAP5 MDM2 CHRNB2 CHRNA1 LIN7B CHRND CHRNB4 CHRNA3 CHRNB3 KCNG1 CHRNA2 KCNG2 CHRNA5 CHRNG KCNG3 GLS2 KCNG4 CHRNA4 CHRNE KCNH1 KCNH2 CHRNA6 CAMK4 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 RAC1 KCNH8 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNN1 KCNN3 GIT1 NRAS KCNN4 SNAP25 KCNF1 KCNC1 KCNC2 RASGRF2 KCNC3 HRAS KCNC4 KCND1 GLUL KCND2 KCND3 KCNAB1 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 RASGRF1 KIF17 KCNA3 KCNA4 CASK KCNA5 LIN7A KCNA6 LIN7C KCNA7 PPM1E PPM1F KCNJ1 GRIN3B KCNJ2 APBA1 KCNJ3 CAMK1 KCNJ4 GABBR2 CHRNA9 KCNJ5 KCNN2 GABBR1 UNC13B KCNJ10 SYT1 KCNJ12 SYN3 KCNJ9 KCNB1 CPLX1 SLITRK3 SYN2 KCNB2 SYN1 KCNJ14 RIMS1 SLITRK5 KCNJ15 GAD1 PPFIA1 KCNJ16 DBNL GAD2 KCNS1 PPFIA4 KCNS2 TSPOAP1 KCNS3 PPFIA3 PPFIA2 HCN2 HCN1 GNAT3 GNG10 GNG12 GNG11 HSPA8 GNG13 ARHGEF9 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNQ2 KCNQ3 GNAI3 STX1A GNAI1 GNAI2 NTRK3 GNG3 CREB1 GNG2 GNG5 GNG4 GNG7 GNG8 GJC1 AP2A1 SLC18A3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.2 TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A KDM5B MYC TFAP2C CDKN1A GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 80%70221 Glycogen breakdown (glycogenolysis) GYG2 GYG1 AGL PYGB PYGM PHKB PHKA1 PHKA2 PGM2L1 PHKG1 PHKG2 GAA PGM2 CALM1 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.3 SOS-mediated signalling IRS1 SOS1 IRS2 HRAS NRAS ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.1 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PPARGC1A PRKAG3 PRKAB1 MAPK14 PRKAA2 MAPK11 PRKAB2 MAPK12 PRKAG1 PRKAG2 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.5 RNA Polymerase II Transcription BMI1 KRAS KDM5B RING1 PARP1 HDAC11 HDAC9 BLM RNF2 HDAC7 WRN CSF1R GTF2B CBX8 PHC2 GTF2E1 PHC1 GTF2E2 RNMT RNGTT CBX4 CDKN2A CBX2 PCGF2 RPA1 BRD2 PHC3 PML EIF4A3 CASC3 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 ATF2 SRSF6 SLU7 SRSF7 PIP4K2A SRSF9 PIP4K2B FYTTD1 PIP4K2C LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 MAPKAP1 U2AF1L4 U2AF2 DHX38 SRSF11 VENTX MOV10 CHTOP ALYREF UPF3B MAGOHB EZH2 PPARG RNPS1 PCNA SLC2A3 FKBP5 RICTOR MBD3 RFC5 MSX2 RFC3 SUZ12 OPRM1 GATAD2B MAF RFC4 GATAD2A DLX5 DLX6 RFC2 TWIST2 HIVEP3 RPA2 PPARGC1B ESRRA SMAD1 RPA3 SMAD6 BMP2 FOXO6 ITGBL1 FOXO4 SP7 AGO3 UCMA FOXO1 ZNF521 AGO4 NKX3-2 AGO1 RBM14 CBX6 AGO2 HAND2 NR4A1 PPM1D BGLAP PRR5 PTEN CHD4 CHD3 NR2E1 EED BRIP1 HDAC5 KAT5 EXO1 RBBP8 MTA2 NBN BARD1 RMI2 TNRC6C RMI1 TRPC3 STUB1 TOP3A TNRC6A RAD51D RAD50 TNRC6B RAD51 PRDX2 PRDX1 STAT1 SMARCD1 SMARCD2 SMARCB1 ARID2 YAF2 SMARCE1 CCNK SMARCC1 SMAD4 PBRM1 ZFHX3 TP53RK MT-CO1 SMARCC2 EHMT1 ACTL6B NOC2L AUTS2 GLS PCGF5 TP53AIP1 ARID1A SMARCA2 HUS1 COX7A2L ARID1B SCO1 RYBP SCO2 DDIT4 MT-CO2 MT-CO3 RHNO1 L3MBTL1 MEAF6 NUAK1 TP53BP2 ATRIP GTF2H1 PRELID3A GTF2H2 BANP PRELID1 GTF2H3 SURF1 GTF2H4 GTF2H5 TPX2 DDB2 SOD2 RAD17 CDK12 ATR COX7B ERCC3 ELL IFNG SETD9 ERCC2 CHM COX7C BBC3 TAF7L ING5 ING2 PIP4P1 EHMT2 AIFM2 ELOA COX8A CBX3 BRD1 SGK1 MEF2C COX5B LMO1 COX5A LMO2 PMS2 TAF9B BRD7 TIGAR MLH1 HIPK1 COX6C POU4F2 LRPPRC HIPK2 PRKAA1 TTC5 PRKAA2 CCNG1 TCEA1 MAP2K6 RAD1 CCNT2 YWHAB PRKAG1 CCNT1 PRKAG2 TACO1 PRKAG3 PRDM1 COX6A1 RPTOR STK11 SESN3 SESN2 AKT2 KMT5A BNIP3L MLST8 SUPT16H AKT1 IGFBP3 SLC38A9 COX6B1 MSH2 FANCD2 PRKAB2 KAT6A MAPKAPK5 COX19 COX16 COX18 TSC2 NDRG1 TSC1 PRKAB1 SMYD2 MTOR PMAIP1 COX11 PPM1A COX14 BCL2L14 RRAGA ZNF420 PTPN4 RRAGC FANCI BRPF1 RHEB BRPF3 RRAGB TNFRSF10C ELOA2 RRAGD SPI1 LAMTOR2 FANCC LAMTOR1 CDK9 LAMTOR4 TP53I3 LAMTOR3 RUNX1 JMY CYCS TAL1 LAMTOR5 TAF4B RARA RAD9B TGFB1 RAD9A CEBPB KMT2A COX20 DYRK2 CBFB PPP1R13B COX4I1 RXRA TRIAP1 DEK PPP1R13L TOPBP1 GPX2 RABGGTB RABGGTA RRM2B TMEM219 GLS2 TAF9 TAF1L TP53INP1 RFFL TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 TAF11 SSRP1 TAF7 TAF6 LBR TAF5 PPARGC1A TAF4 TAF3 TAF2 TAF1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 MED23 MED25 MED24 MED20 PPARA RSPO3 JAG1 CAV1 YY1 KMT2D KMT2C MED30 MED31 USP7 USP9X HDAC6 ITGA5 PGR PPP2R1B CLDN5 SERPINB13 SP1 SOCS4 AXIN1 CCNC GTF2A1 GTF2A2 GP1BA PF4 PCK1 WWTR1 SMARCA4 HNF4G NR5A1 YAP1 PERP GCK SMAD7 TCF3 LDB1 MYBL2 H3-3B CCNA2 CCNA1 NOTCH2 NOTCH3 NOTCH4 KMT2E DNA2 KMT2B POLR2A DPY30 POLR2B MED1 POLR2C POLR2D MED8 POLR2E POLR2F MED4 POLR2G POLR2H POLR2I MED6 POLR2J SETD1B POLR2K MED7 POLR2L SETD1A RARG PPP2R5C ASH2L ELOB ELOC TEAD1 TCF12 RARB MAPK14 IRAK1 DLL1 PLXNA4 CDK8 SMAD2 SMAD3 WDR61 MYB WDR5 ZFPM1 GATA4 GATA3 GATA2 GATA1 SMARCD3 ABL1 NFE2 RBBP5 CBX5 FIP1L1 CDK5 KLF4 SOX2 SOX9 H3C8 HEY1 HEY2 RXRB HDAC2 H3C15 TCF7L2 TCF7L1 MYC TCF7 LEF1 CTNNB1 RUNX3 PHF20 CHEK2 ZNF385A PCBP4 MDM2 MDM4 ATM KIT CDK5R1 NR1H2 THBS1 OPRK1 IL6 DGCR8 GAMT PLK2 RBFOX1 GPRIN1 PVALB HTT MOBP GAD1 GAD2 AFF4 CDC73 CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 LEO1 EAF1 EAF2 PAF1 OCLN TJP1 NOP2 CGA HSPD1 NFYA NFYB DDIT3 NFYC CRH CLP1 SLBP CSTF3 CSTF2 CSTF1 SYMPK POMC PCF11 WDR33 SRRT INS NUDT21 RNF111 PAPOLA NEDD4L CAMK2B GRIA2 CAMK2D SRC CAMK2A CPSF4 GRIN2B CPSF1 CPSF3 CPSF2 GRIN2A CALM1 CAMK2G BAX BID WWP1 CSTF2T CSNK2A1 PABPN1 CSNK2A2 CSNK2B KCTD6 SOCS3 G6PC1 SMURF2 SMURF1 FBXO32 TRIM63 RNF34 AKT3 GPAM JUN FOS YWHAE PPP2R1A PRKACA YWHAG BLK SKP1 ELF1 ELF2 PAX5 PIDD1 APAF1 CRADD SERPINE1 CASP6 RORA CASP1 NR3C1 CASP2 NLRC4 TP63 TP73 SREBF1 UBA52 NR1D1 CUL1 AURKA AR CCNB1 UBB MYL9 UBC RPS27A USP2 BCL2L11 SFN CENPJ BDNF TNFRSF10B TNFRSF10A CDK1 TNFRSF10D ZNF17 FASLG ZNF287 ZNF18 PTPN11 ZNF19 ZNF285 ZNF282 RBX1 ZNF10 ZNF12 ZNF14 ZNF705EP ZNF28 PSMD8 ZNF274 PSMD9 ZNF273 FAS PSMD6 ZNF20 PSMD7 ZNF23 PSMD4 ZNF25 PSMD5 ZNF26 PSMD2 ZNF268 PSMD3 ZNF267 PSMD1 ZNF266 ZNF264 ZNF263 NR2F1 TXNIP ZNF34 PRKCB NR0B2 PSMA5 NR2F6 PSMA6 ZNF30 PSMA3 ZNF257 PSMA4 ZNF256 PSMA1 ZNF254 PSMA2 PSME3 ZNF496 PSME4 ZNF253 PSME1 ZNF493 PSME2 ZNF250 ZNF492 ZNF490 PSMD10 ZNF43 PSMB11 ZNF45 PSMD12 ZNF41 PSMD11 ZNF248 PSMD14 ZNF486 PSMD13 ZNF485 ZNF484 PSMA7 ZNF483 RELA ZNF480 ZNF479 PSMB10 ZNF235 PSMA8 ZNF234 PSMB6 ZNF233 PSMB7 PPARD PSMB4 FOXP3 ZNF230 PSMB5 ZNF471 PSMB2 ZNF470 PSMB3 PSMB1 ZNF227 MEN1 PSMF1 ZNF468 ZNF226 NFKB1 ZNF225 PSMB8 ZNF224 PSMB9 ZNF223 CDC25C ZNF222 SEM1 ZNF221 PSMC5 ZNF461 PSMC6 ZNF460 PSMC3 ZNF77 PSMC4 ZNF79 PSMC1 SKI PSMC2 ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 ZNF213 NCOR2 ZNF697 HDAC3 ZNF454 NCOR1 ZNF696 TBL1XR1 ZNF212 HDAC1 ZNF211 SIN3A ZNF692 CAMK4 ZNF691 GPS2 RORB TBL1X ZNF208 ZNF205 ZNF689 ZNF688 ZNF446 ZNF445 PITX2 EGFR ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 ZNF682 ZNF440 ZNF681 ZNF680 ITGAL ZFP69B ZNF439 ZNF679 ZNF678 ZNF436 ZNF677 ZNF676 ZNF433 ZNF675 ZNF432 ZNF431 ZNF430 ITGA4 ZNF671 BIRC5 ZNF670 TNFRSF18 ZNF840P ZKSCAN7 ZNF429 ZKSCAN8 ZNF669 ZKSCAN3 ZNF668 ZNF426 ZNF667 ZNF425 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 ZKSCAN1 ZNF662 ZNF660 ZNF419 IL2RA ZNF418 ZNF417 ZNF658 ZNF416 ZNF415 ZNF655 NPPA ZNF649 TBX5 ZNF641 NKX2-5 ZNF875 ZNF627 ZNF626 ZNF625 SST ZNF624 ZNF621 ZNF620 ZNF860 LGALS3 MGA ZNF619 CTSV ZNF616 ZNF615 ZNF614 ZNF613 ZNF611 ZNF610 TRIM33 CTSL IHH UXT ZNF729 TRIM28 CTSK ZNF727 PRMT6 ZNF726 NR4A3 ZNF724 EPC1 ZNF721 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 ZNF324B HDAC4 L3MBTL2 ZNF709 ZNF708 SATB2 ZNF707 ZNF706 ZNF704 MMP13 ZNF703 ZNF701 ZNF700 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 SPP1 INTS14 INTS10 HNF4A ZFP14 ZNF585B RXRG ZNF585A ZFP28 PRDM7 ICE1 ICE2 IGFBP1 SSU72 ZNF99 ZNF92 H2AX VDR H2AB1 NABP2 H2AC19 NABP1 TGIF1 ZNF75CP H2AC14 H2BC12L TGIF2 ZNF804B H2BC21 TAF8 ZNF175 ZSCAN32 ZNF169 H2BU1 ZNF705G H2AC8 ZNF705D H2AC6 ZNF160 H2AC7 ZNF705A H2BC17 ZSCAN25 H2BC12 ZNF157 H2BC13 ZNF398 STEAP3 H2BC14 ZNF155 ZNF154 H2AJ H2BC15 ZNF394 H2BC11 NR2C2AP ZNF141 ZNF383 ZNF140 ZNF382 RBBP4 NR1D2 RBBP7 H2AZ1 ELL2 H2BC9 ELL3 ZNF37A H2AZ2 ZNF702P ZNF138 NPM1 ZNF136 ZNF135 H4C9 H2BC8 ZNF133 ZNF124 ZIK1 H2BC5 ZNF599 H2BC3 ZNF114 ZNF597 H2BC1 CAT ZNF596 ZNF112 ZNF595 ZNF350 RETN H2AC20 ZNF589 ZNF347 ZNF473 ZNF587 LSM10 ZNF586 LSM11 ZIM2 BTG1 ZNF343 MSTN ZNF101 SIRT3 ZIM3 FOXG1 ZNF584 ZNF100 NPY ABCA6 ZNF583 CPSF7 UBE2D1 PINK1 ZNF582 CCNG2 PCGF6 AGRP ZNF33B ZNF33A ZNF337 ZNF577 ZNF334 ZNF333 ZNF573 ZNF331 ZNF571 ZNF570 ZFP30 ZNF569 ZNF568 NFATC2 ZNF567 ZNF324 ZNF566 HDAC10 GPI ZNF565 ZFP37 YWHAQ ZNF564 ZNF563 ZNF320 HDAC8 PRKCQ ZNF562 YWHAH ZNF561 ZNF560 NRBP1 ZNF317 ZNF559 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 YWHAZ ZNF554 MRE11 ZNF311 ZNF552 CSF2 ZNF793 ZNF551 ZNF792 ZNF550 ZNF791 ZNF790 KRBA1 KRBOX4 KRBOX5 ZNF767P ZNF549 AURKB ZNF548 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 ZNF782 ZNF540 ZNF658B ESRRB MAPK11 ESRRG ZFP69 ZNF778 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 MAX ZNF772 E2F5 ZNF530 PDPK1 ZNF771 BCL6 ZNF770 COL1A1 CDC7 ZC3H8 ZNF529 ZNF528 ZNF764 ZNF761 ZNF75D ZFP90 E2F6 ZNF75A CR1 ZNF519 CDKN2B ZNF517 RRM2 ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 ZNF740 RPRD2 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 SNAPC5 ZNF607 SNAPC1 ZNF606 SNAPC2 YES1 ZNF605 SNAPC3 ZNF600 SNAPC4 ZNF143 ZNF839 RPAP2 ZNF726P1 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B ATP1B4 RPRD1B RPRD1A POU2F2 NR4A2 THRB THRA GSK3B ZNF197 ZNF195 GLI3 NR2C2 GLI2 NR2C1 ZNF189 ZNF286A ZNF184 ZNF180 TWIST1 ITCH CREBBP NOTCH1 MAML2 MAML1 RBPJ KAT2B KAT2A SNW1 EP300 GTF2F1 HES1 MAML3 GTF2F2 MAMLD1 TP53 LIFR POU2F1 PHAX SNRPD3 TFAP2A TFAP2B PRMT5 WWOX TFAP2C UBE2I TFAP2D SNRPG SUMO1 TFAP2E SNRPE KCTD1 KCTD15 SNRPF SNRPB ACTL6A UBE2D3 CCNH SIN3B CASP10 TBP SIRT1 CDK7 MNAT1 TEAD4 CCN2 TEAD2 CTLA4 TEAD3 PIN1 RB1 CDKN1A ANAPC15 CDKN1B ANAPC16 ANAPC10 ANAPC11 RORC FZR1 CCND3 CDC23 CCND2 CCND1 CDC26 CDC27 E2F1 SKP2 DAXX ANAPC7 UBE2C UBE2E1 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2CA PPP2CB MAPK1 MAPK3 PTPN1 G6PD ATXN3 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CHEK1 APOE CITED1 CITED2 CITED4 YEATS4 MET TGFA ESR1 ESR2 IL2 IL3 CGB8 ATAD2 BTG2 TNKS1BP1 CNOT6L PRMT1 RBL2 RBL1 PLAGL1 E2F4 E2F7 E2F8 PLK3 GADD45A ARID3A CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT1 CNOT11 CARM1 CNOT2 CNOT3 CNOT8 CNOT9 FOXO3 JUNB CREB1 ERBB2 CDK13 ITGA2B VEGFA MDC1 BRCA1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 80%918233 TRAF3-dependent IRF activation pathway RNF135 IFIH1 CREBBP TRIM4 IFNB1 TRIM25 IKBKE MAVS DDX58 EP300 SIKE1 TBK1 IRF3 TRAF3 IRF7 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME DATABASE ID RELEASE 80%8853334 Signaling by FGFR3 fusions in cancer FGFR3 SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.11 Signaling by Interleukins CCL19 CCL22 CCL20 CSF1R NDN IL3RA MAOA EBI3 PTPN13 INPP5D SOCS3 IFNLR1 SOCS1 IL17RE IL17RC IL17RB IL17RA OPRD1 BATF ATF2 CSF2RB CSF2RA CXCL8 CXCL1 CXCL2 MAP2K4 OPRM1 MAP2K7 JUN S1PR1 SYK FOS MAPK9 MAPK8 MAPK10 IRS2 FOXO1 PPP2R1A MYD88 BTRC PRKACA IRAK4 SKP1 HSP90AA1 FBXW11 RORA CASP1 HIF1A STAT1 UBA52 ARF1 CUL1 ANXA1 RALA PITPNA FPR1 FGF2 BOLA2B CNN2 UBB CA1 HNRNPDL STAT4 IL12B IL12A UBC IL12RB1 IL12RB2 JAK1 RPS27A HSPA9 SERPINB2 ANXA2 GSTO1 AIP MSN TYK2 MIF SOD2 SOD1 MTAP VAMP7 IFNG GSTA2 HNRNPA2B1 PDCD4 SNRPA1 LCP1 STAT5A PPIA FASLG STAT5B PTPN11 RBX1 TNFRSF1A MEF2A MEF2C RPS6KA3 JAK2 RPS6KA5 IKBKB RPS6KA2 PSMD8 RPS6KA1 PSMD9 IL1RN ATF1 PSMD6 IL18RAP PSMD7 IL36A PSMD4 IL36B PSMD5 IL1R1 PSMD2 IL1R2 PSMD3 SIGIRR PSMD1 SQSTM1 IKBKG IL36RN MAP3K7 MAP2K6 GSDMD CHUK IL36G PSMA5 IL1F10 PSMA6 IL4 TOLLIP PSMA3 TSLP PSMA4 PTPN20 PSMA1 PTPN23 IL18BP PSMA2 PSME3 IL31RA RIPK2 PSME4 IL13 PSME1 IL18 AKT1 PSME2 IRAK3 IL1A IL1B PSMD10 IL1RAPL1 PSMB11 NOD1 PSMD12 NOD2 PSMD11 PSMD14 IL1RL2 ALOX5 PSMD13 JAK3 MAP3K3 PSMA7 PTPN18 RELA IL37 PTPN12 PTPN14 PSMB10 PSMA8 PTPN9 PTAFR PSMB6 PTPN7 PSMB7 STX4 PTPN4 PSMB4 STX3 PTPN5 PSMB5 IL18R1 PSMB2 CFL1 PTPN2 PSMB3 PSMB1 PSMF1 CSF3R NFKB1 PSMB8 IL6R PSMB9 CRLF1 NFKBIA SEM1 PSMC5 CRLF2 TGFB1 PSMC6 PSMC3 PSMC4 ITGB1 PSMC1 PSMC2 CISH NFKBIB TBK1 STAT6 IL6ST HSP90B1 SHC1 PIK3R1 CBL SNAP25 PIK3CA ITGAM SOS1 NANOG ITGB2 ITGAX RAPGEF1 BIRC5 TNFRSF1B PIK3R2 SOS2 IL2RG IL2RA IL2RB IL32 ICAM1 CRKL IL27RA PIK3R3 LGALS9 LCN2 CASP3 CTSG TIMP1 MMP1 MMP2 MMP3 MMP9 GRB2 IL21 IL22 IL20 IL25 DUSP4 IL26 DUSP3 IL24 IL27 PPP2R5D LAMA5 VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B RHOU F13A1 IL11 IL15 IL19 IL16 IL31 IL34 OSM INPPL1 STX1A RAG2 RAG1 IL4R PRTN3 VCAM1 SMARCA4 IL7R CD36 RPLP0 IL9R TEC CNTF HMOX1 LMNB1 ZEB1 UBE2V1 IL10RB IL10RA CLCF1 CSF3 YWHAZ CSF2 CSF1 IL5RA LYN IGHG4 IGHG1 IL13RA2 PTK2B IL13RA1 MAP2K3 UBE2N TAB3 TAB2 TAB1 MAPK11 VIM MCL1 BCL6 BCL2L1 TRAF6 COL1A2 IGHE LBP CRK IL21R MAP2K1 TNIP2 MAP3K8 YES1 IL23R IL15RA IL23A STXBP2 TWIST1 LIF HCK NOS2 TNF MAPK14 IL33 IL1RL1 TP53 PTPN6 IL11RA LIFR IRAK1 HNRNPF PELI3 PELI2 ALOX15 PELI1 POU2F1 CD4 BRWD1 BLNK SMAD3 APP IFNL2 MUC1 IFNL1 HMGB1 GATA3 IFNL3 NKIRAS1 NKIRAS2 CEBPD IL20RA IL20RB IL22RA2 SOX2 AGER IL22RA1 S100A12 S100B VAMP2 NFKB2 SAA1 CTF1 PTGS2 CDKN1A H3C8 STAT2 RORC PIM1 CCND1 TXLNA MAPKAPK3 MAPKAPK2 H3C15 FSCN1 SOCS2 SOCS5 CXCL10 CAPZA1 PPP2CA PPP2CB MYC MAPK1 PTPRZ1 MAPK3 CCL5 CCL4 CCL3 CCL2 TALDO1 CD86 CDC42 LCK CD80 FYN PAK2 VAV1 CCR1 SDC1 IRAK2 IL10 IL6 CCR5 CCR2 OSMR IRS1 PIK3CD PIK3CB HGF GAB2 P4HB IL17F IL17C IL17A CCL3L3 HSPA8 IL2 IL3 IL5 IL7 IL9 IRF4 TCP1 CNTFR JUNB FOXO3 ELK1 CREB1 BCL2 POMC CANX STAT3 HAVCR2 RAP1B VEGFA FN1 FCER2 CCL11 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.2 Transport of Mature mRNAs Derived from Intronless Transcripts NUP62 NUP214 NDC1 NXF1 SEC13 NUP210 NUP133 ALYREF CPSF4 CPSF1 NUP93 SLBP CPSF3 CPSF2 NUP50 NUP54 NUP205 EIF4E POM121 SYMPK AAAS FIP1L1 NUP160 POM121C NUP42 NUP85 TPR WDR33 NUP88 NUP43 RAE1 NCBP1 RANBP2 NCBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 80%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) ASF1A EP400 HMGA2 H1-1 H1-0 CABIN1 H1-3 H1-2 H1-5 HIRA H1-4 UBN1 LMNB1 RB1 TP53 HMGA1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 80%392517 Rap1 signalling PRKACG PRKACB RAPGEF3 RAF1 RAPGEF4 RAP1GAP2 YWHAB PRKACA RAP1GAP RAP1B RAP1A RASGRP2 RASGRP1 SIPA1 YWHAZ NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 80%383280 Nuclear Receptor transcription pathway NCOR1 RORC VDR RORB NR2F1 RXRB RARB NR0B2 NR2F6 PPARG NR1D1 ESR1 ESR2 NRBP1 MED1 NR1H2 AR NR2C2AP NR1D2 ESRRA PPARD HNF4G NR4A1 NR2E1 NR4A2 RARA PPARA THRB PGR THRA NR5A1 NR2C2 NR2C1 RXRA HNF4A ESRRB RARG ESRRG RXRG RORA NCOR2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 80%453276 Regulation of mitotic cell cycle ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SKP2 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NEK2 AURKB PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 FBXO5 PTTG1 CCNA2 CCNA1 UBA52 CUL1 AURKA CCNB1 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 PLK1 CDK1 RB1 UBE2D1 ANAPC15 CDC14A ANAPC16 ANAPC10 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 80%674695 RNA Polymerase II Pre-transcription Events LEO1 TAF9B EAF1 ELOB EAF2 PAF1 ELOC TCEA1 CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 ELOA2 GTF2B GTF2E1 CDK9 GTF2E2 TAF4B WDR61 GTF2A1 GTF2A2 TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP SSRP1 TAF7 TAF6 TAF5 TAF4 TAF3 CCNK TAF2 TAF1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 SUPT5H ERCC3 ELL ERCC2 TAF7L AFF4 CDC73 ELOA CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.1 Signal amplification GNGT2 GNAI3 GNAT3 GNAI1 GNAI2 GNA14 GNA15 GNG3 MAPK14 GNG2 GNG5 GNG4 GNA11 GNG7 GNG8 P2RY1 P2RY12 TBXA2R GNG10 PLA2G4A GNA13 AAMP GNG12 GNG11 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 80%8873719 RAB geranylgeranylation RAB22A RAB42 RAB2A RAB2B PTP4A2 RAB34 RAB40A RAB40B RAB11B RAB20 RAB40C RAB25 RAB26 RAB4A RAB23 RAB29 RAB13 RAB15 RAB19 RAB17 CHML RAB43 RAB41 RAB32 RAB30 RAB36 RAB35 RAB38 RAB27A RAB3A RAB6B RAB3D RAB44 RAB8A RAB31 RAB37 RAB5B RAB5C RABGGTB RABGGTA RAB6A RAB1A RAB1B RAB21 RAB4B RAB12 RAB9A RAB9B RAB24 RAB10 RAB7A RAB18 RAB5A RAB11A RAB39A RAB39B RAB27B CHM RAB8B RAB33A RAB33B RAB7B RAB3B RAB3C CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 80%5358747 CTNNB1 S33 mutants aren't phosphorylated PPP2CA PPP2CB AMER1 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 80%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 80%72737 Cap-dependent Translation Initiation RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 EIF4EBP1 RPL26 RPL29 RPL28 EIF4E RPS4Y2 EIF4B RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPL26L1 RPS24 RPS23 EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF5 EIF2B1 EIF5B UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.2 Defective DPM2 causes CDG-1u DPM2 DPM3 DPM1 SYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.4 Synthesis of Lipoxins (LX) ALOX12 PTGR1 ALOX5AP LTC4S HPGD ALOX5 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.1 Response of Mtb to phagocytosis TRIM27 RAB7A RPS27A MAPK1 PGK1 RAB5A MAPK3 GSK3A ENO1 DUSP16 KPNB1 VPS33B RNF213 CORO1A ATP6V1H UBA52 HGS KPNA1 NOS2 CTSG SFPQ UBB UBC TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 80%380095 Tachykinin receptors bind tachykinins TAC1 TACR2 TACR1 TACR3 TAC3 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME%R-HSA-5663202.9 Diseases of signal transduction by growth factor receptors and second messengers CNKSR1 KRAS TLN1 RAF1 VCL CAMK2B RNF213 CAMK2D ATG7 SRC HDAC11 CAMK2A NRG1 HDAC9 BCL2A1 ZC3HC1 CALM1 CAMK2G HDAC7 TPR RANBP2 LMO7 CARS1 BTC NRG3 NRG4 NRG2 HBEGF EREG NCBP1 NCBP2 FLT3 MAPKAP1 GSK3A BAD CASP9 AKT3 AGK RICTOR TNKS IRS2 FOXO6 PPP1CB FOXO4 FOXO1 PPP2R1A NR4A1 PRR5 PTEN SKP1 HDAC5 HSP90AA1 PPFIBP1 TNKS2 RPS6KB2 BAG4 ZMYM2 CUX1 FGFR1OP2 MYO18A TRIM24 LRRFIP1 CPSF6 STAT1 AKAP9 ERLIN2 FGFR1 UBA52 SMAD4 FRS2 CUL1 FRS3 FGF1 FGF2 FGF3 FGF4 UBB CTBP2 FGF6 CTBP1 FGF9 FGF20 UBC FGF23 FGF22 FGF10 RPS27A IQGAP1 MSN BCL2L11 CEP43 STAT5A ALK STAT5B PTPN11 FZD5 RBX1 FZD4 FZD6 JAK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SQSTM1 CHUK YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 AKT2 PSME3 PSME4 MLST8 PSME1 AKT1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 RPS6 PSMD13 TSC2 PSMA7 PTPN12 MTOR FKBP1A PSMB10 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 TENT4A PSMB2 DUSP16 PSMB3 KIAA1549 AKT1S1 PSMB1 DUSP10 MPRIP PSMF1 TPM4 AGTRAP PSMB8 TPM3 AP3B1 DUSP8 PSMB9 DUSP9 SND1 SEM1 MRAS PSMC5 TGFB1 PSMC6 CEBPB TGFBR1 KDM7A PSMC3 FAM114A2 TGFBR2 ZC3HAV1 PSMC4 PAPSS1 PSMC1 PSMC2 FXR1 LMNA SHOC2 QKI CLCN6 FAM131B AGGF1 NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X PORCN SHC1 EGF DHH GAB1 PIK3R1 CBL EGFR NRAS MAP3K11 PIK3CA CDC37 WNT3A PLCG1 SOS1 HRAS BCR PIK3R2 DKK1 DKK2 DKK4 ADAM10 ADAM17 FZD8 CSK KREMEN1 KREMEN2 PSEN1 JAG1 NCSTN RNF43 LRP5 LRP6 PIK3R3 SHH IHH SPTBN1 HDAC6 HDAC4 RAC2 GRB2 RHOG FGF16 FGF7 FGF18 PPP2R5D DUSP6 DUSP7 PPP2R1B APC AXIN1 CCNC KANK1 HHAT TRAK1 FGB FGA VWF FGG TFG WDR48 NPM1 HDAC10 EEF1G HDAC8 AMER1 LYN NOX4 PDPK1 BCL2L1 GCC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G MAP2K1 POLR2H POLR2I POLR2J POLR2K POLR2L YES1 PRKAR1A HIP1 PPP2R5E GSK3B PPP2R5B PPP2R5A FGFR3 PPP2R5C CSNK1A1 CREBBP TRIP11 NOTCH1 MAML2 MAML1 KLB RBPJ KAT2B KAT2A SNW1 EP300 GTF2F1 HES1 MAML3 EIF2AK3 GTF2F2 BIRC6 MAMLD1 BCL11A ESRP1 FGFR2 RRBP1 WDCP SPRED3 SPRED2 EML4 SPRED1 FGF19 FGFR4 JAG2 NF1 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SMAD2 SMAD3 ATIC KIF5B KLC1 ETV6 GOLGA4 FIP1L1 CDKN1A CDKN1B PIM1 HEY1 HEY2 HES5 HEYL HDAC2 BRAF PPP2CA TCF7L2 PPP2CB MYC PPM1B MAPK1 CTNNB1 MAPK3 MDM2 KIT CD86 CLTC LCK CD80 CD28 FYN RAC1 VAV1 SEC31A VCP SEL1L DERL2 ERLEC1 OS9 SYVN1 MYH9 IRS1 PIK3CD PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG GAB2 MET PDGFB TGFA CD19 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 DCTN1 JUNB FOXO3 BIN2 CREB1 STAT3 GOLGB1 ERBB2 APH1A ERBIN PSENEN APH1B PSEN2 PHB1 ITGB3 ITGA2B ARAF KDR PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 APBB1IP TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.7 Toll-like Receptor Cascades RPS6KA2 IKBKB RPS6KA1 RBSN ATF1 SIGIRR IKBKG MAP3K7 MAP2K6 TICAM2 GSDMD CHUK MAPKAPK3 MAPKAPK2 CD180 UBE2V1 RIPK2 IRAK3 LGMN NOD1 NOD2 PPP2CA RELA PPP2CB MAPK1 MAPK3 PTPN4 NFKB1 NFKBIA MAP2K3 UBE2N TAB3 TAB2 TAB1 NFKBIB TBK1 MAPK11 CNPY3 HSP90B1 TRAF6 LY86 LBP ITGAM SOCS1 ITGB2 MAP2K1 TNIP2 MAP3K8 IRAK2 PIK3C3 BPI DNM1 DNM2 DNM3 ATF2 APOB BTK CTSV PIK3R4 CTSS TLR9 S100A9 TLR8 S100A8 CTSL TLR7 CTSK MAP2K4 MAPK14 PLCG2 MAP2K7 JUN CTSB FOS MAPK9 MAPK8 MAPK10 IRAK1 PELI3 PELI2 PELI1 PPP2R1A UNC93B1 LY96 CD14 S100A1 MYD88 DUSP4 BTRC DUSP3 TIRAP PPP2R5D TLR1 VRK3 TLR10 DUSP6 TLR6 DUSP7 TLR5 TLR4 MAPK7 PPP2R1B IRAK4 TLR2 SKP1 FBXW11 APP FGB UBE2D3 FGA HMGB1 CASP8 FGG UBA52 NKIRAS1 NKIRAS2 IKBKE TICAM1 TLR3 CUL1 ELK1 CREB1 UBB IRF3 TRAF3 IRF7 UBC RPS27A AGER TANK S100A12 CD36 RIPK1 GSDME ECSIT FADD EEA1 RIPK3 MAP3K1 S100B NFKB2 SAA1 PTPN11 UBE2D2 UBE2D1 MEF2A BIRC2 MEF2C BIRC3 RPS6KA3 RPS6KA5 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.2 Selenocysteine synthesis RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 SEPHS2 RPS6 RPL11 PSTK RPL36A SECISBP2 RPS27L RPS4Y1 EEFSEC RPS15A SEPSECS RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 SARS1 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.1 Toll Like Receptor 5 (TLR5) Cascade IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 TLR10 DUSP6 NFKBIA MAP2K3 DUSP7 TLR5 UBE2N MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB MAP2K1 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER S100A12 ECSIT MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.1 RUNX1 regulates transcription of genes involved in WNT signaling RSPO3 ESR1 CBFB FOXP3 AXIN1 RUNX1 MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.2 Miro GTPase Cycle TRAK1 TRAK2 MFN1 MFN2 RAP1GDS1 RHOT2 RHOT1 MYO19 ADRENOCEPTORS%REACTOME%R-HSA-390696.3 Adrenoceptors ADRA1B ADRA1A ADRA2C ADRB1 ADRA2B ADRA1D ADRA2A ADRB2 ADRB3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 80%71384 Ethanol oxidation ADH4 ACSS2 ALDH1B1 ADH1C ADH1B ADH1A ALDH1A1 ACSS1 ADH7 ADH5 ADH6 ALDH2 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 80%3928662 EPHB-mediated forward signaling CDC42 PAK1 ARPC4 ARPC5 ITSN1 FYN RAC1 ARPC2 ARPC3 KALRN ACTB GRIN2B GRIN1 HRAS SDC2 PTK2 ACTR3 ACTG1 ACTR2 TIAM1 WASL YES1 RASA1 RHOA LYN ROCK2 CFL1 ARHGEF28 ARPC1B ARPC1A LIMK2 LIMK1 ROCK1 MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 80%8851805 MET activates RAS signaling SOS1 MUC20 HRAS HGF RANBP9 MET RANBP10 NRAS RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 80%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CSF2 CBFB LGALS3 CREBBP PRKCB RUNX1 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 80%5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) RAD50 RAD51 RAD51B RAD51C DNA2 RTEL1 BLM MRE11 WRN XRCC3 SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 80%211163 AKT-mediated inactivation of FOXO1A AKT2 FOXO1 AKT1 AKT3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.2 Extracellular matrix organization LTBP4 LTBP2 LTBP3 LTBP1 ITGB8 ITGB6 TGFB2 TGFB3 ITGA8 VTN TRAPPC4 LAMA2 LAMA1 COL11A1 COL11A2 COL10A1 COL28A1 COL27A1 COL24A1 COL22A1 COL1A1 COL3A1 COL2A1 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL5A3 COL4A4 COL7A1 COL5A2 COL6A1 COL4A3 COL8A2 COL4A6 TTR COL20A1 COL6A3 COL8A1 COL4A5 COL21A1 COL6A6 CEACAM1 COL6A5 CEACAM6 CEACAM8 LAMC3 LAMA4 ITGA3 PECAM1 BMP2 ITGB4 F11R NID2 MUSK ITGA7 P3H2 ITGA6 P3H1 P3H3 PDGFA SERPINH1 DDR1 PXDN MATN1 MATN4 DDR2 TNXB SERPINE1 DMD JAM2 JAM3 DSPP PTPRS PLOD3 PLOD2 PLOD1 COMP IBSP TNN TNR PCOLCE ADAM19 ADAM12 PPIB CD151 CRTAP P4HA1 P4HA2 P4HA3 ITGA11 COLGALT2 ITGAE HAPLN1 COLGALT1 ASPN ITGAD PCOLCE2 LRP4 FGF2 NRXN1 DAG1 PRKCA TGFB1 ITGB1 ITGAM ITGB5 PRSS1 SDC4 NCAN COL16A1 ITGB2 COL12A1 SDC2 ITGAL CAPN15 SDC3 BGN CAPN8 CAPN9 ITGAX CAPN6 VCAN CAPNS1 ITGB7 CAPN7 CDH1 CAPNS2 SDC1 CAPN5 BSG CASK THBS1 CAPN2 CAPN3 ITGA4 AGRN CAPN1 PRSS2 CAST PHYKPL ADAMTS2 CTRB2 ADAMTS14 COL23A1 ADAMTS3 CTRB1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 PSEN1 KLK2 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 CD47 ICAM2 ACTN1 A2M ICAM3 ELANE NCAM1 ICAM4 BMP1 ICAM5 COL9A1 ICAM1 COL9A3 COL9A2 FBN2 COL18A1 FBN3 BMP10 COL14A1 ELN LAMC2 LOXL3 LAMC1 CTSV LOXL4 CTSS FBLN1 MMP20 FBLN2 LOXL1 ADAMTS4 P4HB PDGFB FBLN5 ADAMTS5 MMP25 LOXL2 MMP24 EFEMP2 CTSL EFEMP1 BMP7 ADAMTS1 GDF5 CASP3 CTSK MFAP5 TIMP2 MFAP4 CTSG LOX TIMP1 MFAP1 TPSAB1 MFAP3 ADAMTS8 MFAP2 CTSD ADAMTS9 CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 SH3PXD2A DCN PLEC MMP10 ITGAV MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 ITGA5 MMP19 CD44 ITGA9 LAMA5 COL15A1 NTN4 TMPRSS6 LAMA3 ITGA2 PLG ITGA10 FURIN COL19A1 ITGA1 ACAN SPOCK3 SPP1 COL26A1 LAMB3 CMA1 TNC LAMB1 DMP1 CAPN13 CAPN14 CAPN11 CAPN12 CAPN10 FGB TLL2 FGA TLL1 KLKB1 FGG SPARC BMP4 FBN1 VCAM1 LUM MATN3 FMOD LAMB2 ITGB3 ITGA2B KDR FN1 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.3 SUMOylation of DNA methylation proteins BMI1 DNMT3A RING1 DNMT3B CBX8 PHC2 PHC1 CBX4 CBX2 PCGF2 UBE2I DNMT1 PHC3 SUMO1 RNF2 AXON GUIDANCE%REACTOME%R-HSA-422475.6 Axon guidance TLN1 SRC GRIN2B GRIN1 DLG1 DLG3 DLG4 CSNK2A1 CSNK2A2 ROCK1 CSNK2B EIF4A3 CASC3 MAGOH NCBP1 NCBP2 RBM8A PIP5K1C UPF3B MAGOHB RNPS1 VAV3 MAPK8 IRS2 PRKACA TRPC7 HSP90AA1 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 ITSN1 UBA52 DOK2 FRS2 PITPNA MYL6 UBB MYL9 NGEF UBC RPS27A CLASP1 MSN ARPC1B ARPC1A PTPN11 RBX1 RPS6KA3 RPS6KA5 RPS6KA2 PSMD8 RPS6KA1 PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 FARP2 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 RPS6 PSMD13 PSMA7 PLXND1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 CFL1 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 EIF4G1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 ITGB1 PSMC1 PSMC2 TRIO DPYSL4 DPYSL5 DPYSL2 DPYSL3 ARHGAP39 PLXNA1 SRGAP3 ARHGAP35 UNC5A SRGAP1 UNC5B ARPC4 UNC5C ARPC5 UNC5D ISL1 SHC1 ARPC2 ARPC3 GAB1 PIK3R1 AGAP2 PLXNB1 EGFR NRAS GIT1 PIK3CA PLCG1 L1CAM SOS1 HRAS NCK2 NCK1 ACTR3 VAV2 ACTR2 TIAM1 EPHA2 UPF2 LYPLA2 EVL PIK3R2 SOS2 ROCK2 ADAM10 ABL2 DSCAML1 SRGAP2 ZSWIM8 PSEN1 PAK4 NCSTN MSI1 COL9A1 COL9A3 PFN1 COL9A2 PFN2 GRB7 LAMC1 PIK3R3 KALRN SHC3 MYL12B RAP1GAP SPTBN1 CLTCL1 PTK2 WASL MMP2 PTPRC CXCL12 PTPRA MMP9 CNTNAP1 ITGAV NEO1 SPTAN1 SPTB ETF1 ITGA5 RHOC ITGA9 RHOB NTN4 NTN1 MAPK7 MYO10 NELL2 EPHB6 ARHGEF7 EPHB2 EPHB1 LAMB1 EPHB4 SCN1B SCN1A EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 PAK6 ANK2 PAK5 ANK3 SHTN1 KCNQ2 MYO9B KCNQ3 EPHA1 EPHA3 EPHA10 GSPT2 GSPT1 RRAS ST8SIA4 SCN3B ACTG1 SCN3A ST8SIA2 RPL4 RPL5 ARTN RPL30 CD24 RPL3 SCN2A RPL32 SCN2B RPL31 NRP2 RPL34 RPLP1 PPP3CB RPL10L RPLP0 RPL10A CAP1 ARHGEF28 RPL8 RPL6 RPL7 RGMB RPS4X RPS15 RGMA RPL7A RPS14 ENAH RPS17 PABPC1 RPS16 MYH14 RPS19 RELN MYH11 RPL18A RPL36AL CAP2 RPS18 CD72 MYH10 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 SCN9A RPS12 NRTN RPS9 RPL21 SH3GL2 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A DOK1 RPSA TYROBP DOK4 RND1 RPS3A RPL9P9 DOK5 DOK6 SCN8A PRKCQ RPL37A CACNA1D RPL24 CACNA1C ARHGEF11 RPL27 CACNA1H RPL26 CACNA1G ARHGEF12 RPL29 SPTA1 RPL28 CACNA1I RPS4Y2 RPL10 CACNA1S RPL12 RPL11 RPL36A PRNP RPS27L RPS4Y1 RPS15A RPL14 CNTN1 RPS3 CNTN2 RPL13 LYN RPS2 RPL15 LDB1 RPL18 RPL17 RPL19 RPL39L SCN5A RPL41 RPL35A RPL23A RPL3L SCN4A RPS26 SCN4B RPS25 SHANK3 RPS28 CLASP2 RPS27 RPS29 RPL27A LAMA1 LIMK2 RPL22L1 CRMP1 LIMK1 RPS20 FAU RPS21 SLIT1 MAPK11 RPL26L1 RPS24 RPS23 SCN7A SLIT3 SLIT2 PDLIM7 COL4A2 MAPK12 COL4A1 MAPK13 COL6A2 COL4A4 ALCAM SCN11A COL6A1 HOXA2 COL4A3 COL6A3 COL4A5 COL6A6 COL6A5 MAP2K1 PRKACG PRKACB YES1 SCN10A PRKAR2A GSK3B RDX UPF3A RET CLTB NUMB ELOB ELOC SEMA5A MAPK14 GRB10 FLRT3 PLXNC1 SEMA6A SEMA6D CACNB1 RASA1 CACNB2 CACNB3 CACNB4 SEMA7A CUL2 PLXNA2 PLXNA4 PLXNA3 DAB1 LHX3 LHX2 PLXNB3 LHX4 LHX9 TREM2 HSP90AB1 SEMA3A SEMA3E ABL1 ABLIM1 ABLIM2 ABLIM3 SEMA4A SEMA4D CDK5 NFASC KIF4B KIF4A RPS6KA4 RPS6KA6 DAG1 EZR SPTBN4 SPTBN5 MYL12A SPTBN2 VASP SIAH2 SIAH1 DOCK1 ROBO2 SH3KBP1 ROBO1 MAPK1 GFRA1 MAPK3 GFRA3 GFRA2 GFRA4 CXCR4 AKAP5 RANBP9 CDC42 CDK5R1 CLTC PAK1 NRCAM CLTA FYN VLDLR RAC1 PAK3 PAK2 DSCAM NCAN SDC2 EFNA5 EFNA4 EFNB2 GPC1 SDCBP EFNB1 EFNB3 PSPN EFNA1 EFNA3 EFNA2 AGRN GDNF RHOA FES USP33 HJV DCC MYH9 DNM1 DNM2 DNM3 GAP43 DCX NCAM1 PIK3CD PIK3CB GAB2 MET ACTB HSPA8 NRP1 CHL1 CNTN6 ITGA2 ITGA10 ITGA1 ANK1 CREB1 ERBB2 APH1A PSENEN APH1B AP2S1 PSEN2 AP2A1 AP2B1 AP2A2 AP2M1 ITGB3 ITGA2B MAP2K2 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 80%68882 Mitotic Anaphase NUP62 NDC1 SEC13 NUP133 LMNB1 SMC1A NUP93 NUP54 NUP205 POM121 NUP160 PPP2R2A NUP85 RAD21 NUP43 RANBP2 AURKB NUP155 BUB1 CLASP2 RPS27 STAG1 STAG2 NUP35 NUP37 PTTG1 CDCA5 PDS5B PDS5A WAPL TUBB8 TUBB8B TNPO1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C BANF1 RCC1 TUBA1A PPP2R1A RAN KPNB1 UBE2I SUMO1 ANKLE2 DYNLL1 CKAP5 TUBA4A MAPRE1 UBA52 PAFAH1B1 DYNC1I2 SPAST CCNB2 DYNC1LI1 CC2D1B CCNB1 DYNC1LI2 ESPL1 UBB KIF18A UBC CDCA8 RPS27A CLASP1 SKA1 SKA2 DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A VPS4A CDK1 NUF2 NUDC CHMP2B ANAPC15 CHMP4C CHMP2A ANAPC16 DYNLL2 CHMP4B ANAPC10 CHMP3 ANAPC11 PSMD8 INCENP CHMP4A PSMD9 CHMP6 PSMD6 CDC23 CHMP7 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 KIF2A PSMD3 PSMD1 KIF2C KIF2B ANAPC7 PSMA5 UBE2C PSMA6 PSMA3 UBE2E1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 CENPE PSMD10 CENPF ANAPC4 PSMB11 TAOK1 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB PSMB10 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CLIP1 PSMC4 PSMC1 PSMC2 MAD1L1 IST1 NDC80 EMD LBR SPDL1 LEMD3 RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 ZW10 DSN1 RCC2 TUBB6 TUBB3 ZWINT TUBB1 AHCTF1 VRK1 LEMD2 SIRT2 XPO1 TUBA4B NDEL1 PPP2R5D PPP2R1B TUBA8 MIS12 TUBA1C TUBA1B TUBB2B DYNC1I1 TUBB2A TUBAL3 B9D2 TUBA3E KNL1 SPC24 SPC25 TUBA3D ERCC6L TUBA3C ZWILCH ITGB3BP CENPA CENPC KNTC1 CENPT CENPU SGO1 SGO2 CENPH PMF1 CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUP188 UBE2D1 SMC3 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 80%5689896 Ovarian tumor domain proteases TNFAIP3 IFIH1 TRAF6 IKBKG TRIM4 UBA52 VCP TRIM25 ESR1 RIPK2 DDX58 OTUB2 NOD1 UBB OTUD7A NOD2 VCPIP1 TRAF3 TP53 ZRANB1 UBC YOD1 TNIP2 TNIP1 RNF128 RPS27A TNIP3 OTUB1 RHOA RNF135 RIPK1 PTEN CDK1 APC OTUD7B MAVS UBE2D1 OTUD5 OTUD3 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFFR2 HCRT QRFP NPFFR1 HCRTR2 HCRTR1 NPFF QRFPR MRNA EDITING%REACTOME%R-HSA-75072.3 mRNA Editing APOBEC3C APOBEC1 APOBEC2 APOBEC3H ADARB1 APOBEC4 ADAR A1CF APOBEC3A APOBEC3B PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.3 Phospholipid metabolism LPGAT1 CPNE7 PITPNB CPNE6 LCLAT1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A PCYT2 DGAT2 MIGA2 MIGA1 DGAT1 CSNK2A1 STARD7 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 PLA2G10 GPD1 SACM1L CSNK2B PLBD1 SBF1 ARF3 PLA2R1 PLA1A TNFAIP8 CDS1 MTMR14 GDE1 ABHD4 ABHD3 PIK3C2G CHAT PIK3C2B PLA2G3 TNFAIP8L1 TNFAIP8L3 PLD4 TNFAIP8L2 PLD6 PLA2G5 ENPP6 PLA2G6 SBF2 TPTE2 PLD1 RUFY1 PLD3 PTPN13 MTMR3 INPP5D PLD2 MTMR8 PGS1 PTDSS2 GDPD1 PTDSS1 GDPD3 PTPMT1 TPTE GDPD5 OSBPL8 PIK3R6 CHKB MTMR6 TMEM86B INPP5K OSBPL5 CHKA PLEKHA1 STARD10 PNPLA7 PLEKHA2 DGAT2L6 PLEKHA5 CRLS1 PEMT PLEKHA6 PLEKHA3 ALPI CDS2 PLEKHA4 SLC44A5 SYNJ2 ACHE PLEKHA8 SLC44A3 PI4KB SLC44A4 PNPLA6 SLC44A1 SLC44A2 LPCAT1 PCTP OSBPL10 ACP6 PCYT1B PLA2G4F PLA2G12A PCYT1A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PLA2G1B AGPAT1 AGPAT2 SELENOI PIP4K2A AGPAT3 PIP4K2B AGPAT4 AWAT2 PIP4K2C GPAT4 GPAT3 CEPT1 GPAT2 CDIPT PLA2G2F PIP5K1A BCHE PIP5K1B PLA2G2D PIP5K1C PLA2G2E AGK PNPLA8 MBOAT7 PLA2G2A MBOAT1 DDHD2 MBOAT2 DDHD1 ETNPPL GPAM ETNK2 LPCAT4 ETNK1 MTMR9 LPCAT3 MTMR7 LPCAT2 PNPLA3 CHPT1 GPD1L SYNJ1 LPIN1 LPIN2 INPP5J LPIN3 PNPLA2 PTEN ARF1 MTMR1 RAB5A PIP4P1 RAB4A PIK3CG PIK3R5 PIK3R1 PIK3CA OCRL PIK3C3 PIK3R2 INPP5E VAC14 PI4K2B MTMR10 MTMR2 MTMR12 MTMR4 PIK3C2A MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PIK3CD PIK3CB PIK3R4 PIK3R3 BMX INPPL1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 80%437239 Recycling pathway of L1 RPS6KA2 RPS6KA1 CLTC SH3GL2 CLTA SHTN1 L1CAM KIF4B KIF4A RPS6KA4 MAPK1 RPS6KA6 MSN AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 DNM1 DNM2 DNM3 EZR RDX RPS6KA3 DPYSL2 NUMB RPS6KA5 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) RPA3 MLH1 PCNA POLD3 POLD4 MSH3 POLD1 RPA1 POLD2 EXO1 MSH2 LIG1 RPA2 PMS2 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 80%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 80%5654716 Downstream signaling of activated FGFR4 FGF19 FGFR4 FGF16 GAB1 FGF18 PIK3R1 KLB NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.3 Sensory Perception OR4D2 OR4D1 OR5F1 ANO2 OR10Z1 OR52R1 RDH5 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 GUCY2D OR8K1 HSD17B6 GUCY2F HSD17B1 OR4C45 OR5AN1 OR4C46 OR4B1 OR8J3 OR6F1 CALM1 OR8J2 OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 PLB1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR52A4P OR2D3 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P CAMKMT RGS9BP OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 PNLIP OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 GRK1 OR2AK2 GRK7 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR2B3 OR5H6 OR4F5 OR10K2 OR4F4 OR2B2 OR4F3 OR10K1 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 LRP10 OR2A4 OR51A7 LRP12 OR2A2 RTP2 OR52J3 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 CYP4V2 OR51G2 OR51G1 OR52I2 OR52I1 AWAT2 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 SAG OR2B11 OR2AP1 OR51F2 OR51F1 OR2G6 OR5M9 OR52H1 OR5M8 OR1E3 OR1E2 OR4K5 OR2G3 OR1E1 OR2G2 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR1D5 OR2T27 OR51E1 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 TRPM5 TRPM4 SLC24A1 SLC17A8 MSN PDE6B PDE6A PDE6G TAS2R7 TAS2R40 PRKCA TAS2R41 TAS2R8 TAS2R20 TAS2R43 TAS2R46 GRM4 TAS2R1 TAS1R2 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 TAS2R16 TAS2R39 SNAP25 CASK KCNJ2 CHRNA9 CHRNA10 KCNN2 HSPG2 SYN1 MYO1C TWF1 SPTBN1 SPTAN1 SCN1B CNGA2 CNGA4 STX1A SCN3A CNGB1 RHO SCN2A SCN2B SCN9A PRKCQ CACNA1D GSN RAB3A LDB1 SCN4B LRP1 LRP2 PLCB2 DNAJC5 TTR RDX KCNMA1 ADCY3 ITPR3 LRP8 KCNMB1 ATP2B1 GNAL CACNB2 LHX2 PCLO BSN CACNA2D2 SYP CABP2 CABP1 LRRC52 OTOF AKR1C1 AKR1C3 OR11H2 AKR1C4 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 EBF1 OR10AC1 FNTA OR2AE1 FNTB OR11H6 LRAT VAMP2 GNAT1 EZR OR11H7 CAPZB OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 RBP4 CLPS RBP2 OR4K15 RBP3 OR4K14 OPN1LW RBP1 OR4K13 RETSAT OR13J1 OR7A2P OR1I1 OR2K2 OR6S1 OR5M11 CLIC5 OR5M10 RIPOR2 OR2I1P OPN1MW CIB2 RDH12 PJVK RDH11 ESPN EPS8 RDH10 OR10D3 PLS1 RDH16 TPRN OR8B12 TMC1 OR14K1 MYO7A ABCA4 TMC2 OR2J3 MYO3B OR4N5 MYO3A OR2J2 KCNQ4 CAPZA1 OR4N4 FSCN2 OR2J1 TWF2 CAPZA2 OR4N2 PCDH15 OR5P3 USH1C OR5P2 ESPNL EPB41L1 NAPEPLD EPB41L3 OR10C1 OR10J1 OTOG OR11L1 CDH23 OR10J3 XIRP2 OR10J5 EPS8L2 OR10J4 MPP1 GRXCR1 OR5W2 GRXCR2 OR6Y1 OR52B2 WHRN OR52B6 LHFPL5 OR1N2 OTOGL OR1N1 TMIE OR5V1 USH1G STRC OR6X1 OR52A1 MYO15A OR52A5 SLC26A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 DHRS3 OR5T2 OR5T1 OR6V1 DHRS9 OR10G6 OR10G8 OR10G7 OR10G9 GUCA1B GUCA1A GUCA1C OR52W1 OR1S2 OR1S1 SDC4 LDLR OR13D1 OR14C36 SDC2 OR5AS1 SDC3 OR4A4P OR2T8 OR2T7 OR2T6 GPC1 OR2T5 GPC3 OR2T4 OR2T3 SDC1 OR2T2 GPC2 OR13C9 GPC5 OR2T1 OR13C8 GPC4 AGRN OR4X2 OR2L13 GPC6 OR4X1 OR9A4 OR51T1 OR9A2 PPEF1 OPN1SW OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 MYH9 OR1Q1 OR2S2 OR51S1 OR4A47 STRA6 OR5B21 LPL OR1P1 REEP1 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 RLBP1 APOE CNGA1 APOB GPIHBP1 OR56B1 OR2Y1 OR8D4 OR8D2 APOA2 OR56B4 APOC3 OR8D1 APOA1 OR7A17 APOA4 OR6C70 OR6C76 APOC2 OR6C75 OR52Z1P OR6C74 OR13G1 OR14I1 OR10A7 NMT1 OR56A5 GNAT3 OR7A5 OR10A2 OR56A4 OR10A4 OR10A3 OR56A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR6C68 OR8B3 OR13F1 OR8B2 OR12D3 OR12D2 BCO2 BCO1 OR5AU1 RCVRN OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 METAP1 METAP2 OR7G2 GNG13 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 GNB1 OR52N4 OR52N2 SCNN1G OR51L1 CALHM1 GNB3 OR5D18 SCNN1D OR10W1 SCNN1B OR52L2P SCNN1A OR2A42 CALHM3 OR5D16 OR5B3 OR5B2 GNGT1 OR5D14 OR5AL1 OR8H3 OR5D13 OR8H2 OR8H1 OR52M1 OR10V1 OR2AT4 OR4C12 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 APOM OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 RPE65 AKR1B10 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR7C2 OR9G4 OR7C1 OR9G1 OR2A14 OR5G3 OR4E2 NMT2 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 80%391903 Eicosanoid ligand-binding receptors PTGDR2 PTGFR TBXA2R PTGER4 LTB4R PTGER2 CYSLTR1 CYSLTR2 PTGDR GPR17 LTB4R2 PTGER1 PTGIR OXER1 PTGER3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 80%2022090 Assembly of collagen fibrils and other multimeric structures BMP1 COL9A1 COL9A3 COL9A2 COL18A1 LAMC2 LOXL3 LOXL4 CTSV CTSS MMP20 LOXL1 LOXL2 CTSL LOX CTSB MMP7 MMP3 MMP9 PLEC MMP13 ITGB4 COL15A1 ITGA6 LAMA3 PXDN LAMB3 COL11A1 COL11A2 TLL2 COL10A1 TLL1 COL27A1 COL24A1 PCOLCE COL1A1 COL3A1 COL2A1 CD151 COL1A2 COL4A2 COL5A1 COL4A1 COL6A2 COL5A3 COL4A4 COL7A1 COL5A2 COL6A1 COL4A3 COL8A2 COL6A3 COL8A1 COL4A5 COL6A6 COL6A5 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME%R-HSA-9665251.1 Resistance of ERBB2 KD mutants to lapatinib CDC37 HSP90AA1 ERBB2 ERBIN SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 80%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2J2 CYP2C9 CYP1B1 CYP2C8 EPHX2 CYP1A1 CYP2C19 CYP1A2 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.1 Resistance of ERBB2 KD mutants to afatinib CDC37 HSP90AA1 ERBB2 ERBIN COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 80%6811436 COPI-independent Golgi-to-ER retrograde traffic DYNLL1 PAFAH1B3 PLA2G6 DYNC1I1 DCTN6 DCTN5 DCTN1 RAB3GAP2 ACTR10 DCTN4 RAB3GAP1 GALNT2 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 DYNC1LI1 DYNC1LI2 CAPZA3 CAPZA1 CAPZA2 RAB6B RAB18 PAFAH1B2 GALNT1 ACTR1A DYNC1H1 PLA2G4A CAPZB BICD1 BICD2 RAB6A AGPAT3 DYNLL2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 80%1358803 Downregulation of ERBB2:ERBB3 signaling NRG1 RPS27A AKT2 RNF41 ERBB2 AKT1 NRG2 AKT3 USP8 UBB UBA52 UBC IMATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 80%9669917 Imatinib-resistant KIT mutants KIT ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 80%9609736 Assembly and cell surface presentation of NMDA receptors KIF17 CASK LIN7A LIN7C GRIN3B APBA1 CAMK2B NBEA CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN1 GRIN2D GRIN2A DLG1 DLG2 LIN7B DLG3 LRRC7 DLG4 NEFL CAMK2G TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 80%399719 Trafficking of AMPA receptors NSF PRKCG PRKCA GRIP2 GRIP1 TSPAN7 PICK1 GRIA3 GRIA4 CAMK2B GRIA1 GRIA2 CAMK2D PRKCB CAMK2A CACNG8 DLG1 CACNG2 CACNG3 CACNG4 DLG4 CAMK2G EPB41L1 MYO6 AP2A1 AKAP5 MDM2 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.1 Inhibition of nitric oxide production NOS2 KPNB1 KPNA1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.7 Sphingolipid de novo biosynthesis CERS3 CERS4 DEGS1 DEGS2 CERS5 CERS6 SPHK2 SPHK1 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 CERS1 CSNK1G2 CERS2 SAMD8 PPM1L SGMS1 SGMS2 ALDH3B2 SGPL1 ALDH3B1 ORMDL2 ORMDL3 SPTSSB KDSR SPTSSA ORMDL1 SGPP2 SGPP1 ACER2 SPTLC1 FA2H ACER1 SPTLC2 VAPA SPTLC3 VAPB OSBP ACER3 TRANSLATION%REACTOME%R-HSA-72766.4 Translation RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 EEF1G EEF1A1 EEF1D EEF1A2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 EEF1A1P5 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A EEF2 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 HARS1 AARS1 RARS1 KARS1 MARS1 YARS1 DARS1 WARS1 AIMP1 GARS1 AIMP2 SARS1 EPRS1 NARS1 QARS1 PPA1 LARS1 IARS1 FARSA EEF1E1 CARS1 TARS1 FARSB VARS1 TRMT112 EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B SEC61G SEC61B EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF5 EIF2B1 EIF5B PARS2 EARS2 LARS2 PPA2 TARS2 AARS2 SSR1 HARS2 TRAM1 GFM2 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF SRP72 SRP68 SRP19 MTFMT YARS2 NARS2 RARS2 CARS2 VARS2 SRPRA SRPRB MARS2 UBA52 DARS2 SARS2 MTRF1L MTIF2 MTIF3 IARS2 WARS2 RPS27A MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 EIF4EBP1 MRPS10 MRPL36 MRPL37 EIF4E MRPL34 EIF4B MRPL35 MRPL32 MRPL33 RPS6 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 N6AMT1 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 EIF4G1 MRPS18A MRPS21 MRPL47 MRPL48 APEH MRPS7 MRPL45 MRPS6 EIF4A2 MRPL46 EIF4A1 MRPL43 MRPS5 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPS33 MRPL18 MRPL19 MRPS34 MRPS31 MRPL16 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 SPCS3 SPCS2 SPCS1 SEC11A SEC11C ETF1 SEC61A2 SEC61A1 RPN2 RPN1 SRP14 GSPT2 GSPT1 DDOST RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 EEF1B2 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 80%9669926 Nilotinib-resistant KIT mutants KIT NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 80%6807004 Negative regulation of MET activity PTPRJ RPS27A EPS15 SH3GL2 HGF STAM2 PTPN2 SH3GL3 MET UBA52 CBL HGS PTPN1 SH3KBP1 LRIG1 STAM SH3GL1 USP8 UBB UBC LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.1 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H2 NR1H3 MYLIP RXRB DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 80%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 80%114452 Activation of BH3-only proteins TP63 TP73 DYNLL1 BAD E2F1 AKT3 YWHAB PPP3CC YWHAQ TFDP1 AKT2 YWHAH TFDP2 AKT1 BMF BCL2 PPP3R1 TP53 YWHAZ BID YWHAE MAPK8 PMAIP1 TP53BP2 BCL2L11 SFN YWHAG BBC3 PPP1R13B DYNLL2 DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 80%3359462 Defective AMN causes MGA1 CBLIF CUBN AMN REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.2 Regulation of HMOX1 expression and activity BACH1 NFE2L2 MAFK HMOX1 HM13 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 80%68952 DNA replication initiation POLE4 PRIM2 POLE2 PRIM1 POLE3 POLA1 POLE POLA2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME DATABASE ID RELEASE 80%9752946 Expression and translocation of olfactory receptors OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4C46 OR4B1 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR52A4P OR2D3 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR2B3 OR5H6 OR4F5 OR10K2 OR4F4 OR2B2 OR4F3 OR10K1 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP2 OR52J3 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR51F1 OR2G6 OR5M9 OR52H1 OR5M8 OR1E3 OR1E2 OR4K5 OR2G3 OR1E1 OR2G2 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR1D5 OR2T27 OR51E1 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LDB1 LHX2 OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 EBF1 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR1I1 OR2K2 OR6S1 OR5M11 OR5M10 OR2I1P OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 OR2T1 OR13C8 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR1Q1 OR2S2 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR10A3 OR56A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR6C68 OR8B3 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5AL1 OR8H3 OR5D13 OR8H2 OR8H1 OR52M1 OR10V1 OR2AT4 OR4C12 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR7C2 OR9G4 OR7C1 OR9G1 OR2A14 OR5G3 OR4E2 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME%R-HSA-4793952.2 Defective MGAT2 causes CDG-2a MGAT2 DISINHIBITION OF SNARE FORMATION%REACTOME%R-HSA-114516.4 Disinhibition of SNARE formation PRKCG PRKCA STX4 STXBP3 PRKCB BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.1 Biosynthesis of E-series 18(S)-resolvins ALOX15 HPGD ALOX5 LTA4H REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.3 Repression of WNT target genes TCF7L2 TLE4 TLE3 TCF7L1 TLE2 HDAC1 TLE1 TCF7 LEF1 TLE5 CTBP2 CTBP1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME%R-HSA-5578996.4 Defective CYP27A1 causes CTX CYP27A1 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.2 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.3 Eukaryotic Translation Initiation RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 EIF4EBP1 RPL26 RPL29 RPL28 EIF4E RPS4Y2 EIF4B RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPL26L1 RPS24 RPS23 EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF5 EIF2B1 EIF5B UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 MUSCLE CONTRACTION%REACTOME%R-HSA-397014.3 Muscle contraction MYL12A FXYD1 FXYD7 TLN1 FXYD6 SCN9A VCL HIPK1 HIPK2 CAMK2B CAMK2D ACTN2 CAMK2A SCN8A CACNA1C TRIM72 PXN DYSF LMOD1 MYL6B ACTG2 CALD1 ANXA6 MYL10 CALM1 CAV3 CAMK2G TPM2 TPM1 SORBS1 SORBS3 ACTA2 MYLPF MYL5 MYL7 KCNJ11 ABCC9 SCN5A TPM4 TPM3 KCNK10 SCN4A KCNK2 SCN4B KCNK4 SCN7A VIM KCNH2 TMOD3 PAK1 KCNQ1 PAK2 SCN11A ITGB5 KCND1 KCND2 KCND3 SCN10A KCNJ2 KCNJ4 GUCY1B2 GUCY1B1 KCNJ12 ATP2A3 ATP2A2 ATP2A1 SLC8A1 KCNJ14 SLC8A2 RYR1 NOS1 GUCY1A2 RYR2 GUCY1A1 RYR3 SLN CLIC2 NPPC TRDN NPR1 ASPH NPR2 PLN AHCYL1 NPPA TNNI3 STIM1 DMPK TBX5 NKX2-5 FKBP1B CORIN ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI MYL12B KAT2B ATP2B4 ATP2B3 ATP2B2 ATP2B1 KCNK6 KCNK7 KCNK9 SLC8A3 KCNK16 KCNK17 KCNK18 KCNK1 KCNK3 CACNB1 CACNB2 KCNK13 PRKACA ITGA1 DMD TRPC1 SCN1B SCN1A GATA4 AKAP9 MYLK CACNG8 TMOD1 ACTN3 CACNA2D2 TMOD4 ANXA1 KCNK12 TMOD2 KCNK15 CACNG4 MYL4 MYL6 SCN3B MYL1 SCN3A MYL2 WWTR1 MYL3 MYL9 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 NEB FGF14 SCN2A ANXA2 FGF13 SCN2B FGF12 FGF11 KCNK5 MYBPC3 MYBPC1 KCNIP1 MYBPC2 KCNIP2 TNNC1 KCNIP3 TNNC2 KCNIP4 MYH3 TNNT1 TNNT2 TNNT3 ATP1B3 MYH8 ATP1B2 MYH6 ATP1B1 TTN CACNG6 MYH11 ATP1A4 CACNG7 ATP1A3 TNNI1 ATP1A2 TNNI2 ATP1A1 DES TCAP RANGRF FXYD4 FXYD3 FXYD2 MRNA SPLICING%REACTOME%R-HSA-72172.3 mRNA Splicing TXNL4A SNRNP35 SNRPN ZCRB1 WBP11 PRPF4 YBX1 PRPF6 HNRNPUL1 PRPF3 SNRNP27 PPIH SNRNP25 SNRNP200 SNRPC SNRPA PRPF8 ZMAT5 CPSF4 CPSF1 FUS CPSF3 CPSF2 CWC15 CHERP LSM8 ISY1 DDX46 DDX42 PPWD1 USP39 ELAVL1 ELAVL2 SART1 SNRNP70 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 DNAJC8 RBM22 WBP4 PRCC TRA2B DDX23 CSTF2T PABPN1 PUF60 SNRPB2 SMNDC1 HNRNPA0 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 SNRNP48 PPIL3 PPIL4 PPIL6 RBMX POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L EIF4A3 CASC3 MAGOH NCBP1 NCBP2 CDC40 SRRM1 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF UPF3B MAGOHB RNPS1 PTBP1 SNW1 GTF2F1 DHX9 GTF2F2 HNRNPH1 HNRNPA1 HNRNPM HNRNPF HSPA8 SNRPD2 SNRPD1 SNRPD3 DDX5 SNRPG SNRPE SNRPF SNRPB LSM5 LSM4 LSM3 LSM2 HNRNPU HNRNPR LSM7 CCAR1 CLP1 LSM6 SRRM2 AQR CRNKL1 CD2BP2 SF1 CSTF3 CSTF2 PPIE SNU13 RNPC3 PCBP1 CSTF1 SYMPK ZRSR2 PRPF38A HNRNPL FIP1L1 HNRNPK HNRNPD SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PCBP2 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 HNRNPC SRSF10 HNRNPA2B1 SF3A3 SNRPA1 SF3A1 SF3A2 NUDT21 XAB2 PHF5A PRPF31 PDCD7 CWC25 CWC27 CPSF7 EFTUD2 CWC22 PAPOLA MTREX CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.1 Ca-dependent events ADCY3 PRKCG ADCY2 PRKCA ADCY1 ADCY8 CAMK4 PDE1C PDE1B ADCY7 PDE1A ADCY6 ADCY5 CAMK2B CAMK2D CAMK2A PRKX PRKCD CAMKK1 CAMKK2 CREB1 PRKAR2B CALM1 CAMK2G PRKACG PRKACB KPNA2 MAPK1 ADCY9 GRK2 PRKAR1B PRKAR1A NBEA PLA2G4A PRKAR2A PRKACA ADCY4 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.2 Mitochondrial biogenesis CHCHD6 ATP5PO MTERF1 ATP5MG GABPA HELZ2 ATP5MF TWNK ATP5ME SIRT4 SIRT5 PPRC1 POLG2 PERM1 NRF1 PRKAA2 APOO CREBBP APOOL IDH2 DNAJC11 PRKAG1 IMMT PRKAG2 GLUD1 PRKAG3 GLUD2 TMEM11 SSBP1 MAPK14 PRKAB2 CALM1 TFB1M PPARGC1B ESRRA PRKAB1 ACSS2 ATP5F1A NCOA2 ATP5F1B CHD9 MTX2 CYCS RXRA CRTC2 CRTC3 CRTC1 MAPK11 HCFC1 HDAC3 TGS1 NCOR1 TBL1XR1 SAMM50 CAMK4 TBL1X MTX1 MAPK12 SMARCD3 PPARGC1A CARM1 NR1D1 MED1 CREB1 TFAM TFB2M POLRMT CHCHD3 HSPA9 NCOA1 SOD2 NCOA6 ATP5MC1 PPARA DMAC2L ATP5PF ATP5PD SIRT3 ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATF2 ATP5F1D ALAS1 MEF2C MEF2D ATP5F1E MICOS13 MT-ATP8 MICOS10 MT-ATP6 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 80%418597 G alpha (z) signalling events ADCY3 GNGT2 PRKCG ADCY2 PRKCA ADCY1 PRKCE ADCY8 ADCY7 ADCY6 ADCY5 ADRA2C ADRA2B ADRA2A PRKCB GNAI3 GNAT3 GNAI1 RGS17 GNAI2 PRKCQ RGS19 PRKCD RGSL1 GNAZ RGS16 RGS4 GNG3 RGS20 GNG2 PRKCH GNG5 GNG4 GNG7 GNG8 ADCY9 GNG10 GNG12 GNG11 GNG13 GNB2 GNAS GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY4 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 80%167162 RNA Polymerase II HIV Promoter Escape TAF9B TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2B GTF2E1 GTF2E2 ERCC3 ERCC2 TAF4B TAF7L GTF2A1 GTF2A2 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 80%5579028 Defective CYP17A1 causes AH5 CYP17A1 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.1 Defective SERPING1 causes hereditary angioedema KLKB1 SERPING1 F12 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 80%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 80%390450 Folding of actin by CCT TriC CCT6A CCT7 ACTB CCT5 CCT4 CCT3 CCT6B CCT2 TCP1 CCT8 APAP ADME%REACTOME DATABASE ID RELEASE 80%9753281 APAP ADME GSTM1 SULT1A4 ABCC5 SULT1A3 GGT5 GGT7 GGT6 SULT1C4 ABCC3 UGT1A1 SULT1E1 UGT1A9 UGT1A6 GSTP1 GGT3P ACY1 NAT1 NAT2 UGT1A10 GGT1 ABCC1 SULT2A1 ABCG2 ABCC2 UGT2B15 CYP2E1 GSTT1 SULT1A1 ABCC4 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.2 Defective CYP19A1 causes AEXS CYP19A1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.3 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB RNF135 IFIH1 CASP8 IKBKG TRIM4 RIPK1 CHUK CASP10 FADD TRIM25 MAVS DDX58 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.6 Pyruvate metabolism GSTZ1 SLC16A8 SLC16A3 VDAC1 GLO1 PDHB LDHC LDHB LDHA PDPR BSG MPC1 MPC2 SLC16A1 PDK4 PDK3 DLAT PDK2 PPARD PDK1 PDHX PDHA2 PDHA1 PDP1 PDP2 LDHAL6A LDHAL6B ME1 DLD RXRA GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 80%190873 Gap junction degradation DAB2 DNM1 AP2M1 DNM2 CLTCL1 CLTC CLTA MYO6 GJA1 CLTB NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.1 Nucleotide catabolism defects PNP MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 80%1222449 Mtb iron assimilation by chelation LTF RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 80%5362798 Release of Hh-Np from the secreting cell DISP2 IHH SCUBE2 GPC5 NOTUM DHH SHH ADAM17 AGGREPHAGY%REACTOME%R-HSA-9646399.3 Aggrephagy RPS27A PARK7 PCNT DYNLL1 IFT88 CFTR HSF1 DYNC1I1 DYNC1H1 UBA52 PRKN ARL13B VCP CETN1 UBE2N DYNC1I2 UBE2V1 HSP90AA1 DYNC1LI1 DYNC1LI2 UBB DYNLL2 HDAC6 UBC CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.2 CTNNB1 S37 mutants aren't phosphorylated PPP2CA PPP2CB AMER1 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 80%2395516 Electron transport from NADPH to Ferredoxin FDX2 FDXR FDX1 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.1 Defective translocation of RB1 mutants to the nucleus RB1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.5 Diseases of metabolism TPMT CFP SI SGSH SLC35D1 LCT NAGLU IDS GUSB B4GALT7 IDUA B3GAT3 HYAL1 EXT1 EXT2 GCLC GCLM ALG2 MUC13 MUCL1 DPM1 DPM2 DPM3 MAOA CHST3 NOTCH2 NOTCH3 NOTCH4 EPM2A GBE1 GAA G6PC1 GYS2 MTRR GYS1 G6PC3 MMAA PPP1R3C CYP11A1 MMAB FDX1 NHLRC1 MTR MMUT FDX2 GYG2 FDXR SLC37A4 MMACHC MMADHC GYG1 CYP11B2 CYP21A2 CSF2RB CSF2RA CYP2U1 NOTCH1 CYP4F22 SEMA5A TBXAS1 GALNT3 ACY1 IDH1 PAH SLC26A2 DPAGT1 ALG8 ALG9 HGSNAT ALG6 ALG14 ALG13 ALG3 ALG12 ALG1 CHST14 MPDU1 RFT1 ABCA3 CHSY1 MUC1 MUC2 MUC7 MUC4 UBA52 MUC6 NUS1 DHDDS GSS UBB MCCC2 UBC MCCC1 GNS RPS27A CYP7B1 DAG1 CYP27A1 GGT1 SFTPD CYP26C1 KHK UGT1A1 CYP17A1 CYP19A1 CYP1B1 MAT1A SFTA3 SFTPB SFTPC ALDOB DCXR SFTPA2 TALDO1 SFTPA1 RPIA OPLAH AHCY PAPSS2 CUBN AMN SDC4 NCAN SDC2 SDC3 BGN SPON2 B3GALT6 SEMA5B VCAN SPON1 GPC1 THSD7B GPC3 B3GLCT CSPG5 SDC1 PGM1 THBS2 ADAMTS12 GPC2 FMO3 GPC5 THBS1 CSPG4 THSD1 GPC4 THSD4 ADAMTS10 AGRN ADAMTSL1 GPC6 ADAMTS15 ADAMTS2 MUC5AC ADAMTS14 ADAMTS3 ADAMTS13 ADAMTSL5 HSPG2 ADAMTSL4 BCAN ADAMTS19 ADAMTSL3 ADAMTSL2 ADAMTS17 THSD7A HEXB ADAMTS6 HEXA ADAMTS7 SBSPON SSPOP ADAMTS20 GALE ADAMTS16 ADAMTS18 GALNT12 POMT2 POMT1 LFNG C1GALT1C1 GNE CYP11B1 LARGE1 POMGNT1 C1GALT1 B4GAT1 ADAMTS4 ADAMTS5 ADAMTS1 SLC34A2 ADAMTS8 ADAMTS9 MC2R DCN NEU1 CBLIF PC BTD TCN2 PCCA HLCS CD320 ABCD4 PCCB ARSB CTSA ACACA MUC12 ACAN MUC15 LMBRD1 GLB1 MGAT2 MUC3A MUC3B GFPT1 ST3GAL3 MOGS POMC MUC16 MUC17 MUC19 CHST6 MUC20 MUC21 MAN1B1 LUM OGN OMD KERA APRT PRELP UGT1A4 FMOD ALG11 CYP27B1 PNP B4GALT1 HPRT1 CYP26B1 ADA CYP24A1 CYP2R1 MUC5B GALNS GALT SRD5A3 MPI PMM2 DOLK GALK1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.2 SLBP independent Processing of Histone Pre-mRNAs SNRPD3 ZNF473 LSM10 LSM11 SNRPG SNRPE NCBP1 NCBP2 SNRPF SNRPB NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 80%2995410 Nuclear Envelope (NE) Reassembly CHMP4A CHMP6 CHMP7 NUP62 NDC1 SEC13 NUP133 LMNB1 NUP93 TUBB6 TUBB3 TUBB1 NUP54 NUP205 AHCTF1 POM121 VRK1 NUP160 LEMD2 SIRT2 PPP2CA TUBA4B PPP2R2A NUP85 TUBA1A RCC1 PPP2R1A NUP43 RAN KPNB1 NUP155 UBE2I SUMO1 IST1 NUP35 TUBA8 NUP37 TUBA1C TUBA1B ANKLE2 TUBA4A TUBB2B TUBB2A EMD LBR TUBAL3 TUBA3E TUBA3D LEMD3 CCNB2 TUBA3C SPAST CCNB1 CC2D1B RANGAP1 TUBB8 TNPO1 TUBB8B TUBB4B TUBB4A VPS4A CDK1 NUP107 NUP188 CHMP2B CHMP4C CHMP2A BANF1 CHMP4B CHMP3 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.2 Cellular response to starvation RPS11 RPS10 ATP6V1B2 RPL39 ATP6V0D1 RPS13 ATP6V0C RPS12 ATP6V0D2 RPS9 ATP6V1B1 RPL21 RPS7 RPS8 SEC13 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPTOR SESN2 RPL37A RPL24 MLST8 RPL27 RPL26 RPL29 SLC38A9 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A MTOR RPL14 RPS3 SESN1 RRAGA RPL13 RRAGC RPS2 RPL15 RHEB RPL18 RRAGB RPL17 RPL19 RRAGD RPL39L RPL41 LAMTOR2 RPL35A LAMTOR1 RPL23A LAMTOR4 LAMTOR3 RPL3L LAMTOR5 RPS26 RPS25 RPS28 CEBPB RPS27 RPS29 RPL27A RPL22L1 RPS20 SZT2 FAU ATF3 RPS21 SEH1L RPL26L1 NPRL2 RPS24 NPRL3 RPS23 GCN1 WDR59 ASNS EIF2AK4 FLCN MIOS ITFG2 IMPACT DEPDC5 KPTN CEBPG WDR24 SH3BP4 FNIP1 FNIP2 KICS2 CASTOR1 CASTOR2 BMT2 EIF2S2 EIF2S1 EIF2S3 ATF2 TRIB3 DDIT3 ATF4 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A ATP6V1H RPL8 ATP6V1A RPL6 TCIRG1 RPL7 RPS4X RPS15 ATP6V1E1 RPL7A ATP6V0E2 RPS14 ATP6V1G3 RPS17 ATP6V1E2 RPS16 ATP6V1D RPS19 ATP6V1C1 RPL18A RPL36AL ATP6V1F RPS18 ATP6V1C2 RPL36 ATP6V1G1 RPL35 ATP6V0B ATP6V0E1 RPLP2 RPL38 ATP6V1G2 RPL37 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.4 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAE SFN YWHAB CHEK1 CDC25C YWHAQ CHEK2 CDK1 YWHAG YWHAH CCNB1 WEE1 YWHAZ BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 80%9024909 BDNF activates NTRK2 (TRKB) signaling BDNF NTRK2 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 80%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 GCKR NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 GCK NUP37 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.3 Triglyceride catabolism FABP9 PRKACG PPP1CA PRKACB FABP1 FABP2 FABP3 PPP1CB FABP4 PPP1CC FABP5 PLIN3 FABP6 FABP7 PNPLA4 PNPLA5 PLIN1 PRKACA MGLL GPD2 ABHD5 FABP12 CAV1 LIPE INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 80%8963676 Intestinal absorption RSC1A1 SLC2A5 SLC5A1 SLC2A2 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 80%6796648 TP53 Regulates Transcription of DNA Repair Genes ELOB MLH1 ELOC TCEA1 CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 MSH2 FANCD2 JUN TP53 FOS FANCI ELOA2 FANCC CDK9 ATM RAD51D CCNH SSRP1 CCNK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA GTF2H5 CDK13 NELFE DDB2 SUPT5H CDK12 CHEK1 ATR ERCC3 ELL ERCC2 MDC1 ELOA ATF2 BRCA1 PMS2 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME%R-HSA-3595174.1 Defective CHST14 causes EDS, musculocontractural type CSPG4 DCN NCAN BGN CHST14 VCAN BCAN CSPG5 METABOLISM OF RNA%REACTOME%R-HSA-8953854.5 Metabolism of RNA TXNL4A SNRNP35 SNRPN ZCRB1 WBP11 NUP62 NUP214 PRPF4 NDC1 PRPF6 HNRNPUL1 SEC13 PRPF3 NUP210 SNRNP27 HSPA1A PPIH SNRNP25 NUP133 SNRNP200 SNRPC SNRPA PRPF8 ZMAT5 CPSF4 NUP93 CPSF1 FUS CPSF3 CPSF2 CWC15 NUP50 CHERP NUP54 LSM8 NUP205 ISY1 POM121 DDX46 DDX42 PPWD1 AAAS USP39 NUP160 ELAVL1 ELAVL2 SART1 METTL14 POM121C SNRNP70 BCAS2 NUP42 NUP85 RBM5 CTNNBL1 RBM17 TPR BUD31 NUP88 TFIP11 PLRG1 NUP43 SYF2 RAE1 DNAJC8 RANBP2 RBM22 WBP4 PRCC RNMT DDX23 RNGTT NUP155 CSTF2T PABPN1 PUF60 SNRPB2 SMNDC1 HNRNPA0 HNRNPA3 NUP153 PPIL1 WTAP GPKOW CDC5L U2SURP SNRNP40 NUP35 SNRNP48 NUP37 PPIL3 PPIL4 PPIL6 LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 EPRS1 WDR75 IMP4 RRP7A PDCD11 ERI1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 RBMX NOL12 NAT10 WDR46 WDR43 TRMT112 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NXT1 NOL9 NOC4L EIF4A3 CASC3 NOL6 GLE1 EXOSC10 MAGOH PES1 RRP36 NCBP1 UTP6 ZFP36 NCBP2 UTP4 THOC1 TNPO1 RIOK3 THOC3 UTP3 THOC2 WDR18 THOC5 WDR12 CDC40 BYSL THOC7 THOC6 BOP1 TSR1 SRRM1 DDX39A MPHOSPH6 DDX39B RPP30 SARNP FBL ZC3H11A RPP38 SRSF2 DIMT1 FTSJ3 SRSF3 EBNA1BP2 SRSF4 NCL SRSF5 SRSF6 RPP21 SLU7 RPP25 SRSF7 UTP25 SRSF9 ISG20L2 FYTTD1 EMG1 LUZP4 UTP20 NOP14 RBM8A RPP40 POLDIP3 SRSF1 RCL1 U2AF1 RBM28 DDX49 U2AF1L4 DDX47 NXF1 WDR3 U2AF2 NOB1 DHX38 SRSF11 BUD23 CHTOP PELP1 ALYREF UTP15 UPF3B UTP11 MAGOHB DDX52 NXF2B UTP18 RNPS1 SENP3 C1D DDX21 BMS1 RPP14 DCAF13 NOP58 KRR1 PPP2R1A CSNK1D CSNK1E UBA52 TP53RK PRKCD UBB UBC RPS27A GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 HNRNPC HNRNPA2B1 ERCC2 SNRPA1 PSMD8 PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 AKT1 PSME2 EIF4E PSMD10 EIF4B PSMB11 PSMD12 PSMD11 PSMD14 RPS6 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 EIF4G1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 POP5 POP7 POP1 POP4 TSEN54 GTPBP3 SET TRMU TSEN2 MTO1 IGF2BP1 IGF2BP3 IGF2BP2 TRMT61B RTCB ANP32A C2orf49 UPF2 ZBTB8OS RTRAF XPOT KHSRP TRNT1 DDX1 ZFP36L1 TSEN15 TSEN34 FAM98B DHX9 TNFSF13 XPO1 ETF1 DDX5 GSPT2 PPIE GSPT1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 ADAR RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 ZNF473 RPL7A LSM10 RPS14 LSM11 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 CPSF7 RPL35 RPLP2 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A APOBEC3C RPL24 APOBEC1 RPL27 APOBEC2 RPL26 APOBEC3H RPL29 APOBEC4 RPL28 A1CF RPS4Y2 APOBEC3A APOBEC3B NSUN4 RPL10 MTERF4 RPL12 RPL11 TFB1M YWHAZ RPL36A MRM1 RPS27L MRM2 RPS4Y1 MRM3 RPS15A RPL14 PPP2R2A RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A TRA2B RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 MAPK11 RPL26L1 RPS24 RPS23 DKC1 NHP2 POLR2A POLR2B POLR2C POLR2D GAR1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SMG1 SMG9 NOP10 SMG7 SMG8 SMG5 SMG6 UPF1 PNRC2 UPF3A PTBP1 SNW1 GTF2F1 GTF2F2 MAPK14 HNRNPH1 HNRNPA1 HNRNPM HNRNPF RAN HBS1L TUT7 TUT4 GEMIN2 PHAX EDC3 EDC4 SNRPD2 SNRPD1 TTC37 DIS3 SNRPD3 PATL1 PRMT5 WDR77 NT5C3B CLNS1A XRN1 DCP2 GEMIN4 SNRPG DDX6 GEMIN5 PARN WDR61 GEMIN6 SNRPE EXOSC7 EXOSC6 GEMIN7 SNRPF EXOSC5 EXOSC4 GEMIN8 SNRPB EXOSC9 EXOSC8 DDX20 EXOSC3 TGS1 SMN2 DCPS SNUPN EXOSC2 CCNH EXOSC1 PAIP1 LSM1 LSM5 LSM4 LSM3 LSM2 PAN2 LSM7 PAN3 LSM6 DCP1A DCP1B FIP1L1 CDK7 MNAT1 PCBP2 YBX1 MAPKAPK2 PPP2CA EIF4A2 EIF4A1 HSPB1 SUPT5H ADARB1 XRN2 NOP2 HSPA8 SKIV2L TNKS1BP1 CNOT6L TRMT10C ELAC2 PRORP HSD17B10 HNRNPU CNOT10 HNRNPR CNOT4 CNOT6 CCAR1 CLP1 CNOT7 SRRM2 CNOT1 AQR URM1 METTL3 CNOT11 WDR4 CRNKL1 THADA CNOT2 CD2BP2 SF1 CNOT3 LAGE3 SLBP CNOT8 OSGEP ALKBH8 CNOT9 CSTF3 THG1L CSTF2 SNU13 TYW1 RNPC3 LCMT2 TRMT44 PCBP1 CSTF1 TRDMT1 SYMPK PUS3 TRMT10A ZRSR2 TYW5 PRPF38A HNRNPL METTL1 HNRNPK NSUN2 TYW3 HNRNPD TPRKB SUGP1 ADAT1 PRPF19 PQBP1 CDKAL1 TRMT1 NOP56 PCF11 NSUN6 DHX15 DHX16 PUS7 FTSJ1 PRPF40A WDR33 ADAT3 GCFC2 TRIT1 ADAT2 HNRNPH2 SF3B4 QTRT1 SF3B5 DUS2 SF3B2 TRMT9B SF3B3 CTU2 SF3B6 QTRT2 SRRT CTU1 SF3B1 TRMT5 SRSF10 TRMT6 SF3A3 TRMT12 SF3A1 TRMT13 SF3A2 TRMT11 NUDT21 TRMT61A XAB2 PHF5A PRPF31 PDCD7 NUP107 CWC25 NUP188 CWC27 EFTUD2 CWC22 PAPOLA MTREX SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.5 Signaling by Nuclear Receptors RDH5 SRC SMC1A APOD CALM1 RAD21 DLD STAG1 STAG2 KCTD6 H3-3B PDPK1 BTC POLR2A POLR2B MED1 POLR2C POLR2D HBEGF EREG POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RARG ATF2 AKT3 CREBBP MOV10 RARB NOS3 KAT2B GPAM FKBP5 EP300 GTF2F1 GTF2F2 JUN FOS KPNA2 ADH4 AGO3 ADH1C AGO4 ALDH1A1 AGO1 AGO2 POU2F1 KDM3A KDM1B ABCG8 ABCG5 ARL4C EEPD1 KAT5 KDM1A HSP90AA1 TNRC6C MYB TNRC6A TNRC6B HSP90AB1 CPT1A GATA3 TBP NRIP1 FASN AKR1C3 PRKCZ H3C8 CDKN1B CCND1 CYP26C1 RXRB CCNT1 UGT1A3 H3C15 RDH11 AKT2 RDH10 RDH16 AKT1 ADH1A PDHB MYC MAPK1 PDK4 PDK3 MAPK3 DLAT PDK2 PPARD PDK1 PDHX PDHA2 PDHA1 CDK9 RUNX1 RARA CBFB RXRA NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 KDM4A GPS2 TBL1X DHRS3 PPP5C EGF DHRS9 PIK3R1 MYLIP EGFR NRAS PIK3CA HRAS ABCA1 NR1H2 APOC4 NR1H3 APOC1 S1PR3 PIK3R2 SRF ZDHHC7 CPT1B CRABP2 CRABP1 RDH14 CETP RDH13 IGF1R PPID CAV2 SDR16C5 ALDH1A3 ALDH1A2 SCD ALDH8A1 CAV1 APOE CITED1 YY1 AREG APOC2 PIK3R3 ANGPTL3 TGFA GNAT3 ABCG1 ESR1 ESR2 EPGN STRN PTK2 CTSD FKBP4 MMP7 MMP2 MMP3 XPO1 CXCL12 MMP9 FABP5 NCOA2 FABP6 GNG10 PLIN1 PTGES3 GNG12 GNG11 GNG13 FOXA1 TLE3 PGR GNB2 DHRS4 DDX5 JUND GNB1 GREB1 GNB4 SP1 GNB3 CHD1 AXIN1 NR5A2 TFF3 GNB5 TFF1 RXRG GTF2A1 KANK1 GNGT1 GTF2A2 PRMT1 CXXC5 KDM4B GNGT2 USF2 USF1 ZNF217 H2AX FOSB EBAG9 H2AB1 H2AC19 SPHK1 H2AC14 H2BC12L H2BC21 GNAI3 H2BU1 H2AC8 CARM1 H2AC6 GNAI1 H2AC7 GNAI2 H2BC17 H2BC12 FOXO3 H2BC13 ELK1 H2BC14 GNG3 UHMK1 H2AJ CREB1 H2BC15 GNG2 PCK1 BCL2 H2BC11 GNG5 GNG4 GNG7 GNG8 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 NCOA1 H2BC3 CYP26A1 H2BC1 CYP26B1 NCOA3 H2AC20 ZDHHC21 SMC3 HIV INFECTION%REACTOME%R-HSA-162906.2 HIV Infection NUP62 NUP214 NDC1 NEDD4L SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C SLC25A5 NUP42 NUP85 TPR SLC25A4 NUP88 SLC25A6 NUP43 RAE1 RANBP2 GTF2B GTF2E1 GTF2E2 XRCC4 RNMT NUP155 RNGTT NUP153 NUP35 B2M NUP37 FEN1 AP1M2 AP1M1 CUL5 AP1G1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L NCBP1 NCBP2 AP1B1 HLA-A ELMO1 BANF1 HMGA1 PSIP1 PACS1 ELOB RANBP1 ELOC HCK GTF2F1 GTF2F2 LIG1 RCC1 RAN KPNB1 CD4 BTRC SKP1 CCNH UBA52 TBP PDCD6IP CCNK ARF1 UBB UBC CDK7 RPS27A MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ELL TSG101 VPS4B VPS4A ERCC2 MVB12B MVB12A TAF7L PPIA VTA1 VPS37C VPS37D VPS37A ELOA VPS37B RBX1 CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 TAF9B UBAP1 PSMD8 CHMP4A PSMD9 CHMP6 PSMD6 CHMP7 PSMD7 PSMD4 VPS28 PSMD5 CHMP5 PSMD2 PSMD3 PSMD1 TCEA1 CCNT2 DOCK2 PSMA5 CCNT1 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 SUPT16H PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ELOA2 PSMF1 CDK9 PSMB8 KPNA1 PSMB9 SEM1 TAF4B PSMC5 CXCR4 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TAF9 TAF1L LCK TAF15 TAF12 CD28 TAF13 FYN RAC1 TAF10 PAK2 TAF11 SSRP1 TAF7 TAF6 TAF5 XRCC6 TAF4 XRCC5 TAF3 TAF2 TAF1 RANGAP1 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CCR5 LIG4 NMT1 XPO1 FURIN GTF2A1 GTF2A2 NPM1 CD8B AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 NMT2 NUP107 NUP188 AP1S2 AP1S1 AP1S3 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.1 IKBKB deficiency causes SCID IKBKB IKBKG CHUK LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702596 lestaurtinib-resistant FLT3 mutants FLT3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 80%73886 Chromosome Maintenance DAXX ATRX CDK2 BLM WRN RPA1 FEN1 DSCC1 CHTF18 PPP6C RUVBL2 PPP6R3 H3-3B TINF2 TERF1 TERF2 CCNA2 CCNA1 SHQ1 DKC1 NHP2 POT1 TERF2IP DNA2 PIF1 PRIM2 RTEL1 PRIM1 CHTF8 TERT POLR2A POLR2B POLR2C POLR2D GAR1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CTC1 ANKRD28 STN1 ACD POLA1 POLA2 TEN1 H3-4 NOP10 PCNA POLD3 POLD4 POLD1 POLD2 RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 RPA3 WRAP53 H2AX H2AB1 H2AC19 HJURP RSF1 H2AC14 H2BC12L MIS18BP1 H2BC21 RUVBL1 OIP5 H2BU1 H2AC8 H2AC6 H2AC7 KNL1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ITGB3BP CENPA CENPC RBBP4 RBBP7 H2AZ1 H2BC9 CENPT H2AZ2 CENPU NPM1 H4C9 H2BC8 CENPW CENPX H2BC5 H2BC3 SMARCA5 H2BC1 MIS18A CENPH CENPI H2AC20 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.5 ER Quality Control Compartment (ERQC) RNF103 RNF139 TRIM13 RPS27A UGGT2 RNF185 MAN1B1 UGGT1 MARCHF6 UBA52 SEL1L DERL2 OS9 SYVN1 EDEM2 UBB EDEM3 EDEM1 AMFR RNF5 UBC KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.4 Ketone body catabolism ACAT1 BDH1 OXCT1 OXCT2 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template UBE2L6 RCHY1 REV1 MAD2L2 REV3L POLI UBA52 VCP TRIM25 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC POLE4 UBA7 RPS27A RPA3 POLE2 POLE3 USP10 POLH PCLAF USP43 SPRTN NPLOC4 ISG15 UFD1 RPA1 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 80%4687000 Defective MPDU1 causes CDG-1f MPDU1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 80%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 80%5365859 RA biosynthesis pathway AKR1C3 ADH4 ADH1C RDH5 DHRS3 ALDH1A1 CYP26C1 DHRS9 CYP26A1 CYP26B1 CRABP1 RDH14 RDH13 DHRS4 RDH11 RDH10 SDR16C5 RDH16 ALDH1A3 ADH1A ALDH1A2 ALDH8A1 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 80%9608290 Defective MUTYH substrate processing TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.1 TGFBR1 LBD Mutants in Cancer TGFB1 FKBP1A TGFBR1 TGFBR2 SIGNALING BY KIT IN DISEASE%REACTOME DATABASE ID RELEASE 80%9669938 Signaling by KIT in disease YES1 STAT3 LCK LYN PIK3R2 FYN STAT1 PIK3R3 PIK3R1 NRAS PIK3CA SOS1 HRAS STAT5A STAT5B KIT JAK2 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.2 PI and PC transport between ER and Golgi membranes PITPNB DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 80%9663199 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 80%912631 Regulation of signaling by CBL YES1 PIK3CD CRKL PIK3CB LYN PIK3R2 FYN PIK3R3 PIK3R1 VAV1 CBL HCK PIK3CA BLNK CRK SYK RAPGEF1 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.1 Uncoating of the HIV Virion PPIA NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 80%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 ETF1 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UBA52 GSPT2 GSPT1 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L NCBP1 RPLP0 NCBP2 RPL10A RPL8 RPL6 RPL7 UPF1 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%9033658 Blood group systems biosynthesis ST3GAL6 RHCE RHD ST6GALNAC6 FUT10 FUT11 B3GALT4 B3GALT5 ST3GAL4 FUT2 FUT1 ABO FUT4 FUT3 FUT6 ST3GAL3 FUT5 FUT7 FUT9 B3GALT2 B3GALT1 B4GALNT2 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.2 Defective SFTPA2 causes IPF SFTPA2 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 80%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RPS6KA2 IKBKB RPS6KA1 ATF1 SIGIRR IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 UBE2V1 RIPK2 IRAK3 NOD1 NOD2 PPP2CA RELA PPP2CB MAPK1 MAPK3 NFKB1 NFKBIA MAP2K3 UBE2N TAB3 TAB2 TAB1 NFKBIB MAPK11 TRAF6 SOCS1 MAP2K1 TNIP2 MAP3K8 IRAK2 ATF2 BTK S100A9 S100A8 MAP2K4 MAPK14 MAP2K7 JUN FOS MAPK9 MAPK8 MAPK10 IRAK1 PELI3 PELI2 PELI1 PPP2R1A LY96 CD14 S100A1 MYD88 DUSP4 BTRC DUSP3 TIRAP PPP2R5D TLR1 VRK3 DUSP6 TLR6 DUSP7 TLR4 MAPK7 PPP2R1B IRAK4 TLR2 SKP1 FBXW11 APP FGB FGA HMGB1 FGG UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB UBC RPS27A AGER S100A12 CD36 ECSIT MAP3K1 S100B NFKB2 SAA1 MEF2A MEF2C RPS6KA3 RPS6KA5 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 80%6802952 Signaling by BRAF and RAF1 fusions CNKSR1 TLN1 RAF1 VCL CAMK2B AGK CAMK2D YWHAB ATG7 SRC CAMK2A ESRP1 CALM1 CAMK2G BRAF MAPK1 MAPK3 TENT4A KIAA1549 MPRIP AGTRAP AP3B1 SND1 KDM7A FAM114A2 ZC3HAV1 PAPSS1 FXR1 LMNA QKI CLCN6 FAM131B AGGF1 TRAK1 FGB FGA VWF TRIM24 AKAP9 FGG NRAS HRAS MAP2K1 IQGAP1 BCL2L11 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.2 SUMO is proteolytically processed SENP2 SUMO3 SUMO2 SUMO1 SENP5 SENP1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 80%1650814 Collagen biosynthesis and modifying enzymes BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 P4HB COL25A1 COL15A1 P3H2 P3H1 P3H3 COL19A1 SERPINH1 COL26A1 PLOD3 PLOD2 COL11A1 PLOD1 COL11A2 TLL2 COL10A1 TLL1 COL28A1 COL27A1 COL24A1 PCOLCE COL22A1 COL1A1 COL3A1 COL2A1 PPIB COL1A2 COL4A2 CRTAP P4HA1 COL5A1 COL4A1 P4HA2 COL6A2 P4HA3 COL5A3 COLGALT2 COL4A4 COL7A1 COL5A2 COLGALT1 COL6A1 COL4A3 COL8A2 COL16A1 COL4A6 PCOLCE2 COL12A1 COL20A1 COL6A3 COL8A1 COL4A5 COL21A1 COL6A6 COL6A5 ADAMTS2 ADAMTS14 ADAMTS3 COL23A1 COL17A1 COL13A1 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.2 Defective GALNT12 causes CRCS1 MUC1 GALNT12 MUC20 MUC2 MUC21 MUC7 MUC5AC MUC4 MUC6 MUC5B MUC3A MUC12 MUC3B MUC15 MUC16 MUC13 MUC17 MUCL1 MUC19 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 80%177135 Conjugation of benzoate with glycine GLYATL3 GLYATL2 GLYATL1 ACSM1 GLYAT ACSM2B CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.1 CLEC7A (Dectin-1) signaling IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 CARD9 PSMD3 PSMD1 NFATC3 IKBKG MAP3K7 NFATC2 NFATC1 CHUK PYCARD PSMA5 CDC34 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 UBE2V1 PSME4 PSME1 PSME2 CARD11 PSMD10 IL1B PSMB11 PSMD12 PSMD11 PSMD14 CALM1 PSMD13 BCL10 PSMA7 RELA MALT1 PSMB10 PSMA8 CLEC7A PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 UBE2N TAB3 PSMC5 TAB2 PSMC6 TAB1 PSMC3 PSMC4 PSMC1 PSMC2 PDPK1 MAP3K14 TRAF6 UBA3 UBE2M AHCYL1 ITPR1 ITPR2 ITPR3 PLCG2 SYK BTRC PPP3CA SKP1 FBXW11 RELB CASP8 UBA52 PRKCD CUL1 UBB PPP3R1 UBC RPS27A PPP3CB NFKB2 UBE2D2 UBE2D1 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 80%1300642 Sperm Motility And Taxes CATSPER1 KCNU1 CATSPER3 HVCN1 CATSPERB CATSPER2 CATSPER4 CATSPERD CATSPERG BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 80%9027307 Biosynthesis of maresin-like SPMs CYP2D6 CYP2E1 CYP2C9 CYP2C8 CYP3A4 CYP1A2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 80%389513 CTLA4 inhibitory signaling PPP2CA PPP2CB CD86 YES1 LCK LYN CD80 FYN PPP2R1A AKT3 CTLA4 PPP2R5D PPP2R1B PPP2R5E AKT2 AKT1 PTPN11 PPP2R5B PPP2R5A PPP2R5C POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 80%69091 Polymerase switching POLA1 POLA2 PRIM2 PCNA POLD3 PRIM1 POLD4 POLD1 POLD2 RFC5 RFC3 RFC4 RFC1 RFC2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.2 Inwardly rectifying K+ channels GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ1 KCNJ2 KCNJ3 KCNJ8 GNG10 KCNJ4 KCNJ11 GABBR2 ABCC8 KCNJ5 ABCC9 GABBR1 KCNJ10 KCNJ12 GNG12 KCNJ9 GNG11 GNG13 KCNJ14 KCNJ15 GNB2 KCNJ16 GNB1 GNB4 GNB3 GNB5 GNGT1 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.1 Lysosomal oligosaccharide catabolism MANBA MAN2B2 MAN2C1 MAN2B1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 80%2206291 MPS IIIC - Sanfilippo syndrome C HGSNAT SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.3 Serotonin receptors HTR1F HTR6 HTR1D HTR1A HTR7 HTR1B HTR2B HTR5A HTR2C HTR2A HTR1E HTR4 OPSINS%REACTOME DATABASE ID RELEASE 80%419771 Opsins OPN4 OPN1MW OPN3 RGR OPN5 RHO RRH OPN1LW OPN1SW REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 80%174437 Removal of the Flap Intermediate from the C-strand WRN RPA3 TINF2 ACD TERF1 TERF2 POT1 TERF2IP DNA2 PCNA POLD3 POLD4 POLD1 RPA1 POLD2 FEN1 RPA2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 80%422085 Synthesis, secretion, and deacylation of Ghrelin CRHR2 SEC11A LEP SEC11C BCHE UCN INS PLA2G7 PCSK1 IGF1 GCG MBOAT4 ACHE SPCS3 SPCS2 SPCS1 GH1 KLF4 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.2 Diseases of hemostasis GGCX VWF KLKB1 F10 GP1BB F12 F11 GP1BA F2 GP5 TPST2 GP9 TPST1 F8 F9 SERPING1 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.3 Signaling by Activin MAPK1 MAPK3 FOXH1 INHBB INHBA ACVR2B FST ACVR2A FSTL3 SMAD2 SMAD4 SMAD3 ACVR1B ACVR1C DRAP1 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%438066 Unblocking of NMDA receptors, glutamate binding and activation GRIA3 GRIA4 CAMK2B GRIA1 GRIA2 CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN1 GRIN2D GRIN2A DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 80%2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP4F2 CYP4A11 CYP2U1 CYP2C9 CYP1B1 CYP2C8 CYP1A1 CYP2C19 CYP1A2 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 80%1237112 Methionine salvage pathway APIP GOT1 MTAP ADI1 MRI1 ENOPH1 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.2 Intracellular metabolism of fatty acids regulates insulin secretion ACSL4 ACSL3 CD36 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.2 Meiotic recombination MLH1 RAD51C H3C15 CDK4 CDK2 BLM RPA2 MRE11 RPA3 SPO11 BRCA2 TEX15 MSH4 MSH5 RPA1 DMC1 ATM PSMC3IP RBBP8 NBN MND1 MLH3 TOP3A RAD50 RAD51 H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 PRDM9 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 H3C8 BRCA1 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.2 Defective MAOA causes BRUNS MAOA ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.4 ECM proteoglycans NCAM1 COL9A1 COL9A3 COL9A2 LAMC1 ITGB6 TGFB2 TGFB3 ITGA8 DCN ITGAV VTN ITGA9 LAMA5 MUSK ITGA7 LAMA3 ITGA2 TGFB1 ITGB1 LAMA2 ACAN LAMA1 MATN1 MATN4 TNXB SERPINE1 TNC LAMB1 DMP1 DSPP PTPRS COMP IBSP TNN TNR SPARC HAPLN1 ITGB5 ASPN NCAN LRP4 BGN ITGAX VCAN AGRN LUM DAG1 MATN3 FMOD HSPG2 BCAN LAMB2 ITGB3 ITGA2B LAMA4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.1 Mitochondrial tRNA aminoacylation KARS1 YARS2 NARS2 RARS2 GARS1 CARS2 VARS2 MARS2 DARS2 QARS1 SARS2 PARS2 EARS2 LARS2 IARS2 WARS2 PPA2 TARS2 AARS2 HARS2 FARS2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.1 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 80%2129379 Molecules associated with elastic fibres BMP10 LTBP4 LTBP2 FBLN1 LTBP3 FBLN2 LTBP1 ITGB8 FBLN5 ITGB6 EFEMP2 TGFB2 EFEMP1 TGFB3 BMP7 GDF5 BMP4 MFAP5 ITGB5 MFAP4 ITGA8 MFAP1 MFAP3 MFAP2 BMP2 VTN ITGAV ITGB3 TGFB1 ITGB1 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013424 RHOV GTPase cycle VANGL1 CDC42 DST CLTC PAK1 PAK6 TXNL1 PAK2 PIK3R1 MYO9A GIT1 MAP3K11 DLG5 ZNF512B CEP97 SPTBN1 NCK2 NCK1 DEPDC1B WASL SH3RF1 USP9X EPHA2 IQGAP1 CCP110 PEAK1 SPTAN1 PARD6B PARD6A TPM4 TPM3 ARHGAP12 PAK4 RHOV ARHGEF7 GIT2 WDR6 DEFECTIVE F8 SECRETION%REACTOME DATABASE ID RELEASE 80%9672397 Defective F8 secretion F8 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.2 Regulation of TP53 Expression and Degradation RFFL PDPK1 MAPKAP1 CCNA2 CCNA1 AKT3 CCNG1 DAXX UBA52 PRDM1 AKT2 MLST8 AKT1 RICTOR CDK2 USP7 UBB TP53 UBC PPP2CA PPP2CB RPS27A MTOR USP2 PPP2R1A PRR5 PHF20 CHEK2 CDKN2A CDK1 PPP2R1B MDM2 MDM4 ATM RNF34 PPP2R5C SGK1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 80%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SKP2 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 AURKB PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTTG1 UBA52 AURKA UBB UBC RPS27A CDC20 PLK1 RB1 UBE2D1 ANAPC15 ANAPC16 ANAPC10 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 80%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 80%9660826 Purinergic signaling in leishmaniasis infection HSP90AB1 RELA ENTPD1 HMOX1 NLRP3 C3AR1 ENTPD5 PSTPIP1 GSDMD NFKB1 C3 TXNIP PYCARD NFKB2 CTSG IL18 SUGT1 IL1A IL1B MEFV P2RX7 CASP1 P2RX4 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.2 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 PURINE CATABOLISM%REACTOME%R-HSA-74259.6 Purine catabolism PNP XDH NUDT16 NUDT5 NUDT15 ADPRM GDA DNPH1 NT5C NT5C2 NT5C1B NT5C1A ITPA GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 80%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CDC42 TCP1 PAK2 LMNB1 ARF1 RALA PSME2 PITPNA BOLA2B CNN2 CA1 HNRNPDL CAPZA1 STAT4 HSPA9 SERPINB2 ANXA2 HNRNPF GSTO1 AIP MSN CFL1 IL10 MIF RPLP0 SOD2 SOD1 MTAP IFNG GSTA2 HNRNPA2B1 PDCD4 SNRPA1 LCP1 PPIA RAP1B TALDO1 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.1 PTK6 Expression EPAS1 PTK6 HIF1A PELP1 NR3C1 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.10 RAF MAP kinase cascade CNKSR1 KRAS TLN1 RAF1 NRTN VCL CAMK2B CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2B PRKCQ GRIN1 GRIN2D DLG1 SPTA1 DLG2 DLG3 LRRC7 DLG4 NEFL RASGRP1 CALM1 RASGRP4 CAMK2G CSF2 IL5RA IL3RA BCL2L1 MAPK12 BTC NRG3 NRG4 NRG2 HBEGF EREG MAP2K1 PPP2R5E PRKG2 RET PPP2R5B PPP2R5A PPP2R5C CSF2RB CSF2RA FLT3 KLB SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 IRS2 FGF19 RASA1 PPP1CB RASA2 CUL3 FGFR4 RASAL1 RASAL2 PPP2R1A RASAL3 DAB2IP NF1 KBTBD7 UBA52 ANGPT1 TEK FRS2 FRS3 FGF1 FGF2 FGF3 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 FGF22 FGF10 JAK1 RPS27A IQGAP1 FNTA FNTB SPTBN4 SPTBN5 RBX1 JAK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 SPTBN2 PSMD3 PSMD1 YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BRAF JAK3 PSMA7 PPP2CA PPP2CB PSMB10 MAPK1 PSMA8 GFRA1 PSMB6 MAPK3 PTPN7 PSMB7 PPP1CC PSMB4 GFRA3 PSMB5 GFRA2 PSMB2 DUSP16 PSMB3 PSMB1 DUSP10 PSMF1 GFRA4 LAMTOR2 PSMB8 DUSP8 PSMB9 LAMTOR3 DUSP9 SEM1 MRAS PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 KIT PSMC2 SHOC2 RANBP9 PPP5C FYN SHC1 EGF PIK3R1 EGFR NRAS MAP3K11 PIK3CA RASGRF2 SOS1 HRAS PSPN RASGRF1 GDNF PIK3R2 IL2RG PDE6D CSK IL2RA IL2RB NCAM1 IRS1 PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG MET PDGFB TGFA SHC2 SHC3 RALGDS SPTBN1 EPGN PTK2 PTPRA SPTAN1 ARL2 SPTB FGF16 FGF7 FGF18 DUSP4 PPP2R5D DUSP6 DUSP7 PPP2R1B RASGRP3 IL2 IL3 IL5 DUSP5 DUSP2 DUSP1 PAQR3 PTPN3 WDR83 RCE1 ICMT RGL3 FGB RGL1 FGA RGL2 VWF PEA15 IL17RD RAPGEF2 USP17L2 RASGEF1A ABHD17C FGG ABHD17B ABHD17A GOLGA7 ZDHHC9 ARTN ERBB2 PHB1 LYPLA1 ITGB3 ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 APBB1IP RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 80%75955 RNA Polymerase II Transcription Elongation LEO1 EAF1 ELOB EAF2 PAF1 ELOC TCEA1 CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 ELOA2 CDK9 WDR61 CCNH SSRP1 CCNK POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 SUPT5H ERCC3 ELL ERCC2 AFF4 CDC73 ELOA CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 80%442982 Ras activation upon Ca2+ influx through NMDA receptor CAMK2B CAMK2D ACTN2 CAMK2A NRAS GRIN2B RASGRF2 GRIN1 HRAS GRIN2D DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G RASGRF1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 80%5669034 TNFs bind their physiological receptors TNFRSF17 TNFRSF14 TNFSF11 TNFRSF9 EDARADD TNFRSF11B CD70 TNFSF13B TNFSF18 TNFSF14 CD27 TNFSF15 TNFSF13 TNFRSF13B TNFRSF18 EDA2R TNFRSF1B TNFSF6 TNFSF4 TNFSF9 TNFRSF25 TNFSF8 EDAR TNFRSF8 TNFRSF4 LTA TNFRSF1A EDA TNFRSF6B DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.1 Degradation of GLI1 by the proteasome PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 ITCH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PRKACA PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 CUL1 UBB UBC PRKACG PRKACB RPS27A GLI1 SUFU RBX1 NUMB LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 80%140534 Ligand-dependent caspase activation TNFSF10 FAS LY96 CASP8 RIPK1 CD14 TICAM2 FADD TNFRSF10B TNFRSF10A TLR4 TRADD TICAM1 FASLG TRAF2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.3 Ribosomal scanning and start codon recognition RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA RPS3A EIF5 EIF4E RPS4Y2 EIF4B RPS6 RPS27L RPS4Y1 RPS15A RPS3 RPS2 RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPS24 RPS23 RPS27A EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G RPS4X EIF3H RPS15 EIF3E EIF3F RPS14 EIF3C RPS17 EIF3D RPS16 EIF3A RPS19 EIF3B RPS18 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 80%5688399 Defective ABCA3 causes SMDP3 ABCA3 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 80%9672387 Defective F8 accelerates dissociation of the A2 domain F8 REGULATION OF BACH1 ACTIVITY%REACTOME DATABASE ID RELEASE 80%9708530 Regulation of BACH1 activity RPS27A BACH1 MAFK SKP1 CUL1 UBB SKP2 RBX1 UBA52 FBXL17 UBC HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.1 Hyaluronan metabolism HYAL3 ABCC5 HMMR CD44 HAS1 STAB2 HAS3 HAS2 HEXB LYVE1 CHP1 HEXA SLC9A1 GUSB CEMIP HYAL1 HYAL2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 80%1799339 SRP-dependent cotranslational protein targeting to membrane RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 SEC61G SEC61B SPCS3 SPCS2 SPCS1 SEC11A SEC11C SSR1 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SEC61A2 SRP72 SEC61A1 SRP68 SRP19 RPN2 RPN1 SRPRA SRPRB UBA52 SRP14 DDOST RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.3 Beta-oxidation of pristanoyl-CoA ACOT8 CRAT CROT AMACR ACOX2 HSD17B4 ACOX3 ACOXL MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 80%6806942 MET Receptor Activation HGFAC HGF MET SPINT1 HPN SPINT2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 80%937041 IKK complex recruitment mediated by RIP1 IKBKB UBE2D3 RPS27A TRAF6 LY96 IKBKG RIPK1 CD14 TICAM2 CHUK UBA52 RIPK3 UBE2N TLR4 TICAM1 UBE2V1 UBE2D2 UBB UBE2D1 BIRC2 BIRC3 UBC GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization RAB1B RAB2A GOLGA2 GORASP1 MAPK1 USO1 PLK1 GORASP2 CDK1 BLZF1 CCNB2 CCNB1 RAB1A GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.2 GTP hydrolysis and joining of the 60S ribosomal subunit RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF4E RPS4Y2 EIF4B RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPL26L1 RPS24 RPS23 EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF5 EIF5B UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.2 Pre-NOTCH Processing in Golgi ST3GAL6 LFNG NOTCH2 NOTCH3 NOTCH1 B4GALT1 NOTCH4 ATP2A3 ATP2A2 ATP2A1 ST3GAL4 SEL1L FURIN TMED2 ST3GAL3 RFNG MFNG RAB6A FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 80%75094 Formation of the Editosome APOBEC3C APOBEC1 APOBEC2 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013406 RHOQ GTPase cycle MPP7 VANGL1 CDC42EP4 ARHGAP32 CDC42EP3 DIAPH3 CDC42EP2 CFTR ARHGAP33 WWP2 WASL GOPC GFOD1 LAMTOR1 ARHGEF9 STOM OBSCN ARHGEF7 SLC4A7 TFRC RHOQ SNAP23 ARHGAP1 ARHGAP5 ARHGAP35 CDC42 PAK1 SYDE1 PREX1 ITSN1 SCRIB OPHN1 PAK2 GJA1 DLC1 GIT1 TRIP10 FNBP1 STEAP3 PLEKHG3 DEPDC1B CDC42EP1 RAB7A VAMP3 IQGAP1 IQGAP3 ARHGAP17 SLC1A5 ARHGAP21 ARL13B JUP SRGAP2 PAK4 CDC42BPB CDC42BPA GIT2 CPNE8 CAV1 ARHGAP26 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 80%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection CCNH POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 SUPT5H ERCC3 RNMT RNGTT ERCC2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.3 Recycling of bile acids and salts NR1H4 ABCB11 NCOA2 BAAT FABP6 ALB NCOA1 SLC27A5 SLCO1B1 SLCO1B3 ABCC3 STARD5 SLC10A1 SLC10A2 SLC51A SLC51B RXRA SLCO1A2 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.3 Defective GGT1 causes GLUTH GGT1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.3 Gamma-carboxylation of protein precursors F7 GGCX PROC F10 F9 PROS1 GAS6 PROZ BGLAP F2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 80%73980 RNA Polymerase III Transcription Termination POLR3F POLR2K POLR3G POLR2L POLR3H POLR3K POLR3GL POLR1C POLR1D CRCP SSB NFIX POLR3A NFIA POLR2E POLR3B NFIB POLR2F POLR3C NFIC POLR3D POLR2H POLR3E REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-HSA-73943.2 Reversal of alkylation damage by DNA dioxygenases ALKBH5 ASCC1 ASCC2 ASCC3 ALKBH2 FTO ALKBH3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 80%1169410 Antiviral mechanism by IFN-stimulated genes NUP62 KPNA7 NUP214 KPNA4 NDC1 KPNA5 SEC13 NUP210 KPNA3 NUP133 UBE2E1 FLNA NUP93 EIF2AK2 NUP50 NUP54 NUP205 EIF4E USP41 POM121 USP18 AAAS NEDD4 NUP160 ABCE1 KPNA2 PPM1B POM121C NUP42 NUP85 MAPK3 TPR NUP88 NUP43 KPNB1 RAE1 RANBP2 EIF4G3 EIF4G2 KPNA1 EIF4E3 OASL NUP155 UBE2N EIF4G1 EIF4E2 NUP153 OAS1 OAS2 EIF4A2 OAS3 EIF4A1 NUP35 NUP37 PDE12 UBE2L6 HERC5 STAT1 UBA52 TRIM25 MX2 MX1 PLCG1 DDX58 UBB IRF3 UBC JAK1 UBA7 RPS27A EIF4A3 IFIT1 ARIH1 ISG15 RNASEL PIN1 NUP107 NUP188 FLNB CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 80%69273 Cyclin A B1 B2 associated events during G2 M transition CCNH CDC25B CCNA2 CCNA1 CCNB2 CCNB1 CDK2 WEE1 PPP2CA PPP2CB XPO1 CDK7 MNAT1 PPP2R2A PPME1 PPP2R1A PKMYT1 PLK1 CDC25A FOXM1 CDC25C CDK1 PPP2R1B LCMT1 PPP2R3B INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 80%264876 Insulin processing SLC30A5 PCSK2 ERO1B EXOC8 STX1A EXOC7 MYRIP PCSK1 CLTRN EXOC4 EXOC3 EXOC6 CPE EXOC5 EXOC2 EXOC1 RAB27A ERO1A MYO5A INS VAMP2 KIF5C KIF5B KIF5A SLC30A7 SLC30A6 SLC30A8 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.2 Peptide chain elongation RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 EEF1A1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A EEF2 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 80%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF CNKSR1 FGB KRAS FGA TLN1 VWF RAF1 VCL CAMK2B FGG CAMK2D YWHAB SRC CAMK2A NRAS MAP3K11 HRAS CALM1 CAMK2G MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 PHB1 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP PROTEIN METHYLATION%REACTOME DATABASE ID RELEASE 80%8876725 Protein methylation PRMT3 ETFB METTL21A RPS2 KIN METTL22 EEF2KMT ETFBKMT VCPKMT EEF1AKMT2 EEF1AKMT1 HSPA8 EEF2 VCP EEF1A1 CAMKMT CALM1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-450341.1 Activation of the AP-1 family of transcription factors MAPK9 MAPK8 MAPK10 MAPK1 MAPK3 MAPK14 MAPK11 JUN ATF2 FOS DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 80%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.5 SARS-CoV-2 Infection RPS11 RPS10 ATG14 RPS13 ZCRB1 RPS12 NUP62 NUP214 RPS9 NDC1 RPS7 SEC13 RPS8 NUP210 RPS5 NUP133 RPSA RPS3A YWHAQ NUP93 UBE2V1 YWHAH NUP50 NUP54 NUP205 POM121 RPS4Y2 AAAS NUP160 YWHAZ RPS27L RPS4Y1 POM121C RPS15A NUP42 NUP85 RPS3 RPS2 TPR NUP88 NUP43 RAE1 RANBP2 MAP1LC3B NUP155 RPS26 UBE2N VHL RPS25 TAB3 RPS28 TAB2 RPS27 TAB1 RPS29 NUP153 IFNAR1 RPS20 FAU RPS21 RPS24 NUP35 B2M RPS23 NUP37 PDPK1 TRAF6 IL17RC IL17RA HLA-H HLA-B GSK3B HLA-C HLA-A HLA-F HLA-G HLA-E GSK3A CSNK1A1 AKT3 CREBBP TLR8 TLR7 YWHAE KPNA2 PTPN6 IRAK1 NLRP3 GEMIN2 TLR1 SNRPD2 SNRPD1 SNRPD3 YWHAG TLR2 GEMIN4 UBE2I SNRPG HSP90AA1 GEMIN5 SUMO1 GEMIN6 SNRPE GEMIN7 IFNA5 SNRPF IFNA4 GEMIN8 SNRPB UVRAG DDX20 IFNA7 IFNA6 SMN2 HSP90AB1 IFNA2 IFNA8 IFIH1 STAT1 TRIM4 UBA52 GJA1 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 SIKE1 UBB IRF3 TRAF3 IRF7 UBC IFNA10 JAK1 RPS27A GALNT1 RNF135 TKFC TYK2 PATJ SFN VPS39 VPS18 IFNA21 LARP1 VPS11 IFNB1 VPS16 ISG15 SRPK2 SRPK1 SFTPD NLRP12 MAVS CRB3 VPS33A G3BP1 PTPN11 RB1 G3BP2 PALS1 CHMP2B CNBP CHMP4C VPS41 CHMP2A STAT2 CHMP4B CHMP3 IKBKB CHMP4A CHMP6 CHMP7 IKBKG MAP3K7 CHUK YWHAB AKT2 RIPK2 AKT1 NOD1 NOD2 RPS6 VPS45 SEC23A VPS33B SEC24B SEC24A SEC24D SEC24C TBK1 STING1 TUFM ZDHHC8 VCP SDC4 SAR1B SDC2 SDC3 GPC1 GPC3 SDC1 GPC2 MBL2 GPC5 IRAK2 GPC4 AGRN GPC6 PIK3C3 HSPG2 BECN1 CAV1 PIK3R4 CTSL TJP1 IL17F IL17A TMPRSS2 ACE2 MASP1 DDX5 FURIN PRMT1 ST6GALNAC2 RPN2 TUSC3 ZDHHC20 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 GOLGA7 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS PARP10 PARP6 ZDHHC11 PARP4 DDOST PARP16 MGAT4C PARP9 ZDHHC9 PARP14 DAD1 PARP8 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 RPS4X RPS15 RPS14 RPS17 RPS16 RPS19 NUP107 RPS18 NUP188 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 80%8934903 Receptor Mediated Mitophagy CSNK2A1 MAP1LC3A CSNK2A2 FUNDC1 ULK1 ATG12 CSNK2B ATG5 MAP1LC3B ERYTHROPOIETIN ACTIVATES RAS%REACTOME DATABASE ID RELEASE 80%9027284 Erythropoietin activates RAS EPO SOS1 IRS2 HRAS CRKL EPOR LYN SHC1 VAV1 RAPGEF1 NRAS JAK2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 80%2033515 t(4;14) translocations of FGFR3 FGFR3 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME%R-HSA-9022707.1 MECP2 regulates transcription factors PPARG CREB1 MEF2C RBFOX1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.2 Thrombin signalling through proteinase activated receptors (PARs) GNGT2 F2R F2 GNA14 GNA15 GNG3 GNG2 GNG5 GNG4 GNA11 GNG7 GNG8 MAPK1 MAPK3 GNG10 F2RL2 F2RL3 GNA13 GNG12 GNA12 GNG11 GNG13 GNAQ GNB2 ARRB1 GNB1 ARRB2 GNB4 GNB3 GNB5 GNGT1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 80%381070 IRE1alpha activates chaperones YIF1A HDGF TLN1 ATP6V0D1 TPP1 SULT1A3 GSK3A HSPA5 SERP1 DNAJC3 ADD1 SSR1 LMNA HYOU1 ARFGAP1 PDIA6 GOSR2 CUL7 SHC1 SRPRA DCTN1 SRPRB SEC31A WFS1 GFPT1 SYVN1 PREB KDELR3 PLA2G4B ACADVL FKBP14 MYDGF TATDN2 TSPYL2 DDX11 PDIA5 ERN1 WIPI1 CTDSP2 DNAJB11 CXXC1 PPP2R5B EXTL2 EXTL1 DNAJB9 EXTL3 EDEM1 ZBTB17 KLHDC3 DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.1 Defective OGG1 Localization DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 80%5658471 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 80%4419969 Depolymerisation of the Nuclear Lamina PRKCA CTDNEP1 CNEP1R1 PRKCB EMD LMNB1 CDK1 LEMD3 CCNB1 LPIN1 LPIN2 LPIN3 LEMD2 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 80%444821 Relaxin receptors INSL5 RXFP4 RXFP3 INSL3 RLN2 RLN3 RXFP1 RXFP2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.3 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 CHEK2 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 UBB UBC RPS27A CHEK1 CDC25A DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 80%9672396 Defective cofactor function of FVIIIa variant F8 F10 F9 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 80%210500 Glutamate Neurotransmitter Release Cycle RAB3A GLS2 UNC13B SYT1 ARL6IP5 SLC1A1 CPLX1 SNAP25 SLC1A2 STX1A SLC1A3 RIMS1 SLC1A6 PPFIA1 VAMP2 SLC1A7 PPFIA4 TSPOAP1 PPFIA3 GLS PPFIA2 SLC38A2 SLC17A7 OLEOYL-PHE METABOLISM%REACTOME%R-HSA-9673163.1 Oleoyl-phe metabolism PM20D1 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 80%2672351 Stimuli-sensing channels RAF1 ANO2 BEST2 SLC9C1 BEST3 NEDD4L SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 WNK1 WNK2 CALM1 WNK3 UNC80 TSC22D3 ANO9 WWP1 ANO7 ANO4 ANO5 ANO3 ANO1 SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 STOM CLCA3P TPCN2 TPCN1 CLCN7 CLCN5 CLCN4 OSTM1 UNC79 CLCN6 RYR1 RYR2 RYR3 ANO6 CLIC2 TRDN ASPH FKBP1B SRI TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 SCNN1G TRPC7 TRPC5 SCNN1D MCOLN3 SCNN1B TRPC6 SCNN1A TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 UBA52 UBB ANO8 UBC RPS27A SGK1 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 80%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 80%2024101 CS DS degradation HYAL3 CSPG4 DCN BCAN ARSB HEXB IDS HEXA NCAN IDUA BGN VCAN HYAL1 CSPG5 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME%R-HSA-4724289.2 Defective ALG6 causes CDG-1c ALG6 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 80%173599 Formation of the active cofactor, UDP-glucuronate UGDH SLC35D1 UGP2 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.2 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 80%844456 The NLRP3 inflammasome HSP90AB1 RELA HMOX1 NLRP3 PSTPIP1 NFKB1 TXNIP PYCARD NFKB2 SUGT1 MEFV P2RX7 PANX1 CASP1 APP LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 80%9615710 Late endosomal microautophagy UBAP1 CHMP4A CHMP6 CHMP7 VPS28 CFTR PLIN3 PLIN2 UBA52 UBB HDAC6 UBC RPS27A PARK7 PCNT IFT88 RNASE1 HBB ARL13B HSPA8 TSG101 CETN1 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%190373 FGFR1c ligand binding and activation FGF1 FGF2 FGF4 FGF6 ANOS1 FGF9 FGF20 FGF23 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.1 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.3 Activation of HOX genes during differentiation YY1 PIAS2 MEIS1 PAX6 CREBBP RARB KMT2D EZH2 KMT2C H3C15 EP300 ZNF335 SUZ12 JUN RARA EED MAFB PCGF2 RXRA PAGR1 WDR5 HDAC3 NCOR1 H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L CNOT6 H2BC21 AJUBA H2BU1 H2AC8 H2AC6 H2AC7 PAXIP1 HOXA3 HOXA2 H2BC17 PBX1 CNOT9 HOXA1 H2BC12 H2BC13 POLR2A CTCF HOXA4 H2BC14 POLR2B RBBP5 H2AJ POLR2C H2BC15 POLR2D H2BC11 POLR2E POLR2F POLR2G RBBP4 POLR2H EGR2 RBBP7 POLR2I POLR2J H2AZ1 POLR2K H2BC9 POLR2L H2AZ2 H4C9 H2BC8 HOXB4 HOXB3 H2BC5 HOXB2 H2BC3 HOXB1 KDM6A HOXD1 H2BC1 NCOA6 NCOA3 HOXC4 H2AC20 HOXD4 HOXD3 RARG H3C8 ASH2L ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.2 Anchoring of the basal body to the plasma membrane CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 C2CD3 TCTN3 TCTN2 TCTN1 TUBB CC2D2A CEP131 IQCB1 HAUS4 HAUS3 KIF24 HAUS6 TMEM216 CSNK1D FBF1 HAUS5 TTBK2 CSNK1E TMEM67 TUBG1 NPHP1 DYNLL1 NPHP4 CKAP5 MARK4 HAUS2 SEPTIN2 TUBA4A SCLT1 HAUS1 AHI1 AKAP9 CEP162 CEP63 CEP83 MAPRE1 B9D1 CEP89 SFI1 SDCCAG8 CEP97 PAFAH1B1 B9D2 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 RPGRIP1L PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 RAB3IP NDE1 CEP152 PLK1 RAB11A TUBB4B TUBB4A NEDD1 CENPJ ALMS1 MKS1 CDK1 CEP41 CEP43 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 80%68875 Mitotic Prophase PRKCA CTDNEP1 NUP62 CNEP1R1 NUP214 NDC1 SEC13 NUP210 USO1 NUP133 PRKCB LMNB1 H3C15 NUP93 KMT5A NUP50 NUP54 NUP205 POM121 AAAS NUP160 PPP2CA PPP2CB POM121C NUP42 MAPK1 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP37 RAB1A RAB1B H3-3B NCAPH2 EMD NCAPG2 MCPH1 NCAPD3 LEMD3 SET H3-4 BANF1 RAB2A NUMA1 LPIN1 LPIN2 VRK1 LPIN3 LEMD2 NEK9 NEK6 NEK7 PPP2R2D ENSA MASTL PPP2R1A ARPP19 PPP2R1B GOLGA2 GORASP1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 H2AC6 GORASP2 H2AC7 BLZF1 H2BC17 H2BC12 H2BC13 H2BC14 CCNB2 H2AJ CCNB1 H2BC15 H2BC11 H2AZ1 H2BC9 SMC4 H2AZ2 SMC2 H4C9 H2BC8 H2BC5 H2BC3 PLK1 H2BC1 H2AC20 CDK1 RB1 NUP107 NUP188 H3C8 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 80%881907 Gastrin-CREB signalling pathway via PKC and MAPK MMP3 RPS6KA2 RPS6KA1 PRKCA MAPK1 MAPK3 EGFR NRAS GAST MAPK7 CCKBR SOS1 HRAS CREB1 HBEGF RPS6KA3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 80%2033519 Activated point mutants of FGFR2 FGF22 FGF10 FGF16 FGF7 FGF18 FGF1 FGF2 FGF3 FGF4 FGFR2 FGF6 FGF9 FGF20 FGF23 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.3 Formation of the cornified envelope LCE5A TGM1 SPRR2A TGM5 SPRR2B SPRR2D SPINK6 PKP2 SPINK5 PKP1 PKP3 CDSN DSC1 LCE6A DSC2 DSC3 IVL SPRR1A LCE2D SPRR1B LCE3C LCE3D SPINK9 LCE3A LCE3B LCE3E LCE4A LELP1 RPTN TCHH DSG3 DSG4 CELA2A PI3 SPRR3 CSTA FURIN LIPJ LIPN LIPM DSP LIPK FLG LORICRIN LCE1A LCE1B KAZN DSG1 PKP4 EVPL PRSS8 CAPNS1 LCE1E CASP14 LCE1F DSG2 LCE1C LCE1D CAPN1 LCE2B LCE2C LCE2A JUP PPL ST14 PCSK6 SPRR2E SPRR2F PERP SPRR2G KLK13 KLK14 KLK5 KLK12 KLK8 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 80%964739 N-glycan trimming and elongation in the cis-Golgi MANEA MGAT1 MAN1A2 MAN1A1 MAN1C1 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 80%1482798 Acyl chain remodeling of CL HADHB HADHA LCLAT1 PLA2G6 TAFAZZIN PLA2G4A INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME DATABASE ID RELEASE 80%428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.2 Defective CYP2U1 causes SPG56 CYP2U1 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 80%110331 Cleavage of the damaged purine H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 MPG H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 OGG1 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 80%5679096 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 80%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose RXRA NR1H2 NR1H3 PLIN1 RXRB ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 80%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.2 MGMT-mediated DNA damage reversal MGMT INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140837.8 Intrinsic Pathway of Fibrin Clot Formation VWF KLKB1 F10 SERPIND1 GP1BB F12 F11 GP1BA F2 GP5 GP9 F8 PROC SERPINE2 F9 SERPINC1 SERPING1 PROS1 PRCP KNG1 SERPINA5 C1QBP A2M TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.3 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 PROC F10 F9 PROS1 GAS6 PROZ BGLAP F2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.3 ADP signalling through P2Y purinoceptor 1 GNGT2 GNG10 PLA2G4A GNG12 GNG11 GNG13 GNAQ GNB2 GNA14 GNB1 GNB4 GNA15 GNG3 GNB3 MAPK14 GNG2 GNG5 GNB5 GNG4 GNA11 GNG7 GNGT1 GNG8 P2RY1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 80%948021 Transport to the Golgi and subsequent modification NSF COPZ1 ARF5 SPTBN2 SEC13 GRIA1 USO1 LMAN2 STX5 FUCA1 TRAPPC10 ARCN1 SPTA1 B4GALT2 CAPZA1 B4GALT3 CAPZA2 TRAPPC2 SEC16B SEC22B TRAPPC3 SEC23A TRAPPC4 SEC16A B4GALT6 TRAPPC5 B4GALT4 B4GALT5 TRAPPC9 SEC24B SEC24A CNIH1 CNIH2 CNIH3 MCFD2 SEC24D SEC24C PPP6R1 BET1L ARFGAP1 SEC22A ARF3 SEC22C RAB1A RAB1B PPP6C PPP6R3 TRAPPC1 SEC31A FOLR1 BET1 KDELR1 COL7A1 MANEA SAR1B CHST10 CHST8 MGAT3 TMED2 COG8 COG7 COG6 LMAN1L COG5 COG4 CTSZ ARFGAP3 COG3 COG2 COG1 ARFGAP2 PREB ANKRD28 KDELR2 KDELR3 LMAN1 LMAN2L CTSC MIA2 TMED3 YKT6 TMED7 TMED9 NAPB ST8SIA6 STX17 NAPG ST8SIA3 AREG SEC23IP COPG2 COPG1 TGFA CD59 SCFD1 CD55 SPTBN1 TRAPPC2L FUT3 TBC1D20 CAPZA3 LHB COPB2 COPA TMED10 MAN2A2 COPB1 SPTAN1 ACTR1A CGA SPTB TMEM115 COPE ANK1 MAN1A2 MAN1A1 TRAPPC6A CSNK1D TRAPPC6B GOLGA2 GORASP1 DYNLL1 ARF4 GOSR2 ANK2 GOSR1 DYNC1I1 DCTN6 ANK3 DCTN5 DCTN1 ACTR10 DCTN4 MAN1C1 FUT8 F5 MAN2A1 MGAT5 ST3GAL4 NAPA DYNC1I2 F8 DCTN2 MGAT1 MGAT2 DCTN3 ARF1 ST6GAL1 DYNC1LI1 MIA3 TFG DYNC1LI2 MGAT4C ST8SIA2 MGAT4A MGAT4B GOLGB1 DYNC1H1 GBF1 B4GALT1 SERPINA1 INS CAPZB SPTBN4 SPTBN5 COPZ2 DYNLL2 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.4 O-linked glycosylation CFP B3GNT7 B3GNT4 B3GNT3 B3GNT2 B4GALT6 B4GALT5 MUC13 MUCL1 GALNT11 GALNT14 SPON2 GALNT13 SEMA5B GALNT16 SPON1 GALNT15 THSD7B GALNT18 GALNT17 B3GLCT GALNT10 THBS2 POFUT2 ADAMTS12 LARGE2 THBS1 B3GALNT2 THSD1 GALNTL5 THSD4 ADAMTS10 GALNTL6 B3GNTL1 ADAMTSL1 ADAMTS15 GALNT9 ADAMTS2 GALNT8 MUC5AC ADAMTS14 POMGNT2 ADAMTS3 B3GNT9 ADAMTS13 B3GNT8 ADAMTSL5 B3GNT6 ADAMTSL4 B3GNT5 ADAMTS19 CHST4 ADAMTSL3 GCNT1 ADAMTSL2 GCNT3 ADAMTS17 GCNT4 THSD7A GCNT7 ADAMTS6 GALNT7 ADAMTS7 GALNT6 SBSPON GALNT5 SSPOP GALNT4 ADAMTS20 A4GNT POMK ADAMTS16 ADAMTS18 GALNT12 POMT2 POMT1 C1GALT1C1 LARGE1 POMGNT1 C1GALT1 B4GAT1 ADAMTS4 ADAMTS5 ADAMTS1 SEMA5A ADAMTS8 ADAMTS9 GALNT3 MUC12 MUC15 MUC1 ST6GALNAC2 MUC2 MUC7 MUC4 MUC6 GALNT2 ST3GAL4 MUC3A MUC3B ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 MUC16 MUC17 MUC19 MUC20 MUC21 GALNT1 DAG1 ST6GALNAC3 ST6GALNAC4 MUC5B ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 80%211976 Endogenous sterols CYP11B1 PTGIS CYP8B1 CYP19A1 POMC CYP11A1 CYP51A1 FDX1 FDX2 FDXR NR1H4 CYP7B1 CYP11B2 NCOA2 CYP21A2 CYP7A1 CYP27A1 CYP1B1 NCOA1 CYP46A1 CYP39A1 RXRA AHR ARNT ARNT2 AHRR CYP4V2 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.6 Fructose catabolism ALDOB TKFC ALDH1A1 KHK GLYCTK INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 80%5638303 Inhibition of Signaling by Overexpressed EGFR EPGN BTC AREG EGF HBEGF EREG TGFA EGFR SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 80%162699 Synthesis of dolichyl-phosphate mannose DPM2 DPM3 DPM1 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.2 Mitotic Metaphase Anaphase Transition FBXO5 PLK1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%500753 Pyrimidine biosynthesis CAD DHODH UMPS SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.1 Sensing of DNA Double Strand Breaks RAD50 KPNA2 KAT5 ATM NBN MRE11 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 80%9726842 Gain-of-function MRAS complexes activate RAF signaling MRAS ARAF RAF1 PPP1CB PPP1CC SHOC2 YWHAB BRAF SCN4%REACTOME%R-HSA-3282872.2 SCN4 G6PC3 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.1 Phase 4 - resting membrane potential KCNJ2 KCNJ4 KCNK5 KCNK13 KCNJ12 KCNK10 KCNK2 KCNJ14 KCNK4 KCNK6 KCNK12 KCNK7 KCNK9 KCNK15 KCNK16 KCNK17 KCNK18 KCNK1 KCNK3 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.1 Intra-Golgi traffic NSF STX16 NAPG CUX1 GOSR2 GOSR1 CYTH3 RGP1 CYTH2 CYTH4 TRIP11 MAN1C1 CYTH1 MAN2A1 STX6 STX5 NAPA RIC1 GOLGA5 ARF1 GOLIM4 RAB41 COG8 RAB30 COG7 RAB36 COG6 SNAP29 COG5 VPS45 COG4 MAN2A2 COG3 COG2 COG1 VTI1A RAB39A ALPP YKT6 MAN1A2 MAN1A1 BET1L RAB33B NAPB PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%75896 Plasmalogen biosynthesis GNPAT DHRS7B AGPS SYNTHESIS OF PE%REACTOME%R-HSA-1483213.3 Synthesis of PE CEPT1 PCYT2 CHKB ETNPPL CHKA PISD ETNK2 ETNK1 PHOSPHO1 LPIN1 SELENOI LPIN2 LPIN3 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.1 Masitinib-resistant KIT mutants KIT RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.2 Response of EIF2AK1 (HRI) to heme deficiency ASNS TRIB3 PPP1R15A CEBPG EIF2S2 EIF2S1 EIF2S3 CHAC1 CEBPB ATF3 DDIT3 EIF2AK1 GRB10 ATF5 ATF4 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 80%9645460 ALPK1 signaling pathway ALPK1 TAB3 RPS27A TAB2 TAB1 TIFA TRAF6 UBB MAP3K7 UBA52 UBC DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 80%3296469 Defects in cobalamin (B12) metabolism MMUT MMACHC MMADHC CBLIF CUBN AMN TCN2 CD320 ABCD4 MTRR MMAA LMBRD1 MMAB MTR MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME%R-HSA-9022927.1 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.3 Surfactant metabolism NAPSA CCDC59 CSF2RB PGA3 CSF2RA PGA5 PGA4 ADORA2A GATA6 TTF1 ADORA2B ADGRF5 ADRA2C CKAP4 ZDHHC2 ADRA2A SLC34A2 SLC34A1 P2RY2 ADA2 CTSH SFTA3 SFTPB SFTPC SFTPD SFTPA2 SFTPA1 ABCA3 DMBT1 LMCD1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.2 Transport of Mature Transcript to Cytoplasm FYTTD1 LUZP4 RBM8A POLDIP3 NUP62 SRSF1 NUP214 U2AF1 NDC1 U2AF1L4 NXF1 SEC13 U2AF2 NUP210 DHX38 SRSF11 NUP133 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 CPSF4 NUP93 CPSF1 CPSF3 CPSF2 NUP50 NUP54 NUP205 EIF4E POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP37 SLBP SYMPK FIP1L1 NXT1 EIF4A3 CASC3 WDR33 GLE1 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 NUP107 SRSF4 NUP188 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-HSA-2473224.2 Antagonism of Activin by Follistatin INHBB INHBA FST FSTL3 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.2 FGFR1 mutant receptor activation BAG4 ZMYM2 CUX1 FGFR1OP2 MYO18A TRIM24 LRRFIP1 CPSF6 STAT1 ERLIN2 GAB2 FGFR1 PIK3R1 PIK3CA FGF1 FGF2 BCR FGF4 FGF6 FGF9 FGF20 FGF23 STAT3 CEP43 STAT5A STAT5B HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.3 Hydrolysis of LPC PLA2G15 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLBD1 PLA2G4A GPCPD1 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.1 Scavenging of heme from plasma IGKV1-17 IGKV1-12 HP IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 AMBP V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 LRP1 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD163 JCHAIN APOA1 ALB HBA2 HPR HPX IGHA1 IGHA2 HBB APOL1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 MPS IX - NATOWICZ SYNDROME%REACTOME DATABASE ID RELEASE 80%2206280 MPS IX - Natowicz syndrome HYAL1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.1 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling SKP1 CUL1 RBX1 NOTCH1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 80%211897 Cytochrome P450 - arranged by substrate type CYP4A22 CYP4A11 CYP3A43 CYP2A7 CYP2A6 CYP2U1 CYP11B1 POR CYP26C1 CYP3A5 CYP2C9 CYP2C18 CYP2C8 CYP3A7 CYP2B6 CYP2A13 CYP2F1 CYP4F22 CYP4F12 CYP2W1 CYP2J2 CYP2S1 CYP4F2 CYP4F3 CYP4B1 CYP4F8 CYP4F11 TBXAS1 CYP3A4 CYP19A1 CYP1A1 NCOA2 CYP1B1 CYP46A1 CYP39A1 RXRA ARNT CYP1A2 PTGIS CYP8B1 POMC CYP11A1 CYP51A1 FDX1 FDX2 FDXR NR1H4 CYP7B1 CYP11B2 CYP21A2 CYP7A1 CYP27A1 NCOA1 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP2R1 CYP2D6 AHR CYP2E1 ARNT2 AHRR CYP4V2 CYP2C19 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 80%69109 Leading Strand Synthesis POLA1 POLA2 PRIM2 PCNA POLD3 PRIM1 POLD4 POLD1 POLD2 RFC5 RFC3 RFC4 RFC1 RFC2 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 80%1632852 Macroautophagy ATG14 CHMP4A CHMP6 CHMP7 PLIN3 SQSTM1 PRKAA1 PRKAA2 ATG7 PRKAG1 PRKAG2 PRKAG3 RPTOR MFN1 MFN2 UBE2V1 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 MAP1LC3B LAMTOR3 LAMTOR5 CSNK2A1 UBE2N CSNK2A2 ATM CSNK2B MTMR14 MTMR3 PRKN VCP VDAC1 TOMM20 TOMM22 PARK7 GABARAPL3 IFT88 ATG3 ULK1 PIK3C3 GABARAPL1 ATG9B ATG9A ATG10 ATG13 ATG101 BECN1 MTERF3 ARL13B ATG16L1 CETN1 WDR45 MAP1LC3A MAP1LC3C FUNDC1 RB1CC1 USP30 WIPI1 WIPI2 PEX5 ATG4C ATG4B ATG4A ATG4D WDR45B AMBRA1 NBR1 CFTR PIK3R4 HDAC6 TOMM40 HSF1 HSPA8 TOMM7 HSP90AA1 TOMM5 TOMM6 UVRAG DYNLL1 PLIN2 DYNC1I1 UBA52 TOMM70 DYNC1I2 EPAS1 ATG12 DYNC1LI1 DYNC1LI2 UBB GABARAPL2 UBC RPS27A PCNT GABARAP DYNC1H1 ATG5 CHMP2B CHMP4C PINK1 CHMP2A CHMP4B DYNLL2 CHMP3 HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 80%162587 HIV Life Cycle TAF9B UBAP1 CHMP4A CHMP6 CHMP7 NUP62 NUP214 VPS28 NDC1 CHMP5 NEDD4L SEC13 NUP210 NUP133 TCEA1 CCNT2 CCNT1 NUP93 SUPT16H NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 ELOA2 RANBP2 GTF2B GTF2E1 CDK9 KPNA1 GTF2E2 XRCC4 RNMT NUP155 RNGTT TAF4B CXCR4 NUP153 NUP35 NUP37 FEN1 TAF9 TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF7 TAF6 TAF5 XRCC6 TAF4 XRCC5 TAF3 TAF2 TAF1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J RANGAP1 POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NELFA NCBP1 NELFE NCBP2 SUPT5H CCR5 LIG4 BANF1 HMGA1 PSIP1 ELOB RANBP1 ELOC NMT1 GTF2F1 GTF2F2 LIG1 XPO1 RCC1 RAN CD4 FURIN GTF2A1 GTF2A2 CCNH UBA52 TBP PDCD6IP CCNK UBB UBC CDK7 MNAT1 RPS27A GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 TSG101 ELL VPS4B VPS4A ERCC2 MVB12B MVB12A TAF7L PPIA VTA1 VPS37C NMT2 VPS37D VPS37A ELOA NUP107 VPS37B NUP188 CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.2 Sema4D mediated inhibition of cell attachment and migration ARHGAP35 RHOA RRAS RAC1 MET SEMA4D PLXNB1 RND1 SIGNALING BY NTRK2 (TRKB)%REACTOME%R-HSA-9006115.2 Signaling by NTRK2 (TRKB) CDK5R1 RAC1 DOCK3 GAB1 PIK3R1 SRC NTF4 NRAS BDNF PIK3CA NTRK2 GRIN2B PLCG1 SOS1 HRAS NTF3 FRS2 FRS3 PTPN11 TIAM1 CDK5 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702577 semaxanib-resistant FLT3 mutants FLT3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.1 Interaction between L1 and Ankyrins SCN9A NRCAM SPTBN2 ANK2 ANK3 KCNQ2 KCNQ3 SCN8A SCN11A SPTBN1 L1CAM SPTA1 SCN3B SCN3A NFASC SPTAN1 SCN2A SCN10A SCN2B SPTB SCN5A SCN4A SCN4B ANK1 SPTBN4 SPTBN5 SCN7A SCN1B SCN1A SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 80%9663891 Selective autophagy NBR1 CFTR PLIN3 SQSTM1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 MFN1 MFN2 UBE2V1 PRKAB2 HDAC6 PRKAB1 TOMM40 HSF1 HSPA8 MAP1LC3B CSNK2A1 UBE2N CSNK2A2 TOMM7 HSP90AA1 ATM TOMM5 TOMM6 CSNK2B DYNLL1 PLIN2 DYNC1I1 UBA52 PRKN VCP TOMM70 DYNC1I2 EPAS1 ATG12 DYNC1LI1 VDAC1 TOMM20 DYNC1LI2 TOMM22 UBB UBC RPS27A PARK7 PCNT IFT88 ULK1 DYNC1H1 ATG5 MTERF3 ARL13B CETN1 MAP1LC3A FUNDC1 USP30 PEX5 PINK1 DYNLL2 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 80%6811558 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling INSR PIP4K2C IER3 IRS1 PIK3CD FLT3 PIK3CB AREG PDGFRB PIP5K1A PDGFRA PIP5K1B HGF PIP5K1C FLT3LG GAB2 PIK3R3 MET PDGFB SRC TGFA KLB CD19 NRG1 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 AKT1 IL33 IL1RL1 PPP2CA PPP2CB MAPK1 IRS2 RAC2 IRAK1 FGF19 MAPK3 FGFR4 PPP2R1A RHOG FGF16 FGF7 FGF18 MYD88 PPP2R5D PPP2R1B IRAK4 KIT CD86 LCK CD80 CD28 FYN RAC1 TRAF6 EGF GAB1 VAV1 PIK3R1 EGFR PIK3CA FRS2 BTC NRG3 FGF1 NRG4 FGF2 NRG2 FGF3 HBEGF FGF4 EREG FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 PIK3R2 ERBB2 INS PPP2R5E PTPN11 PPP2R5B PPP2R5A PPP2R5C PIP4K2A PIP4K2B BETA DEFENSINS%REACTOME DATABASE ID RELEASE 80%1461957 Beta defensins DEFB129 DEFB103B DEFB128 DEFB127 DEFB1 DEFB126 DEFB125 DEFB124 DEFB123 DEFB121 DEFB107B DEFB104B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFB134 DEFB113 DEFB133 DEFB112 DEFB132 DEFB108B DEFB110 DEFB108C DEFB105B DEFB109B CCR6 TLR1 CCR2 DEFB106B TLR2 DEFB130A DEFB4B DEFB130B DEFB131A PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.2 Phosphorylation of Emi1 FZR1 CDK1 FBXO5 CDC20 CCNB1 PLK1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.5 GPVI-mediated activation cascade CDC42 PIK3CB PDPK1 LCK FYN LAT RAC1 PIK3CG PIK3R3 PIK3R5 PIK3R1 VAV1 PIK3R6 PIK3CA PDPN CLEC1B MPIG6B GP6 PLCG2 VAV2 VAV3 SYK LCP2 PTPN6 RAC2 PRKCZ RHOA PIK3R2 LYN RHOG RHOB PTPN11 FCER1G COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 80%204005 COPII-mediated vesicle transport NSF STX17 NAPG AREG SEC13 SEC23IP GRIA1 USO1 TGFA CD59 LMAN2 SCFD1 STX5 TRAPPC10 TRAPPC2L TBC1D20 TMED10 TRAPPC2 SEC22B SEC16B SEC23A TRAPPC3 TRAPPC4 SEC16A TRAPPC5 TRAPPC9 SEC24B SEC24A CNIH1 CNIH2 CNIH3 MCFD2 SEC24D SEC24C PPP6R1 SEC22A SEC22C TRAPPC6A RAB1A CSNK1D RAB1B PPP6C TRAPPC6B GOLGA2 GORASP1 PPP6R3 TRAPPC1 GOSR2 SEC31A F5 FOLR1 BET1 COL7A1 NAPA F8 SAR1B TMED2 TFG LMAN1L CTSZ PREB ANKRD28 LMAN1 LMAN2L SERPINA1 CTSC YKT6 NAPB NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 80%9026357 NTF4 activates NTRK2 (TRKB) signaling NTRK2 NTF4 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 80%211999 CYP2E1 reactions CYP2D6 CYP2S1 CYP2A7 CYP2A6 CYP2E1 CYP2C9 CYP2C8 CYP2B6 CYP2A13 CYP2C19 CYP2F1 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 80%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction CRB3 TJP1 PALS1 PATJ GJA1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.3 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription RBL1 HDAC1 E2F4 E2F5 TGIF1 TGIF2 UBA52 CCNT2 CCNT1 CDKN2B CCNK SMAD4 SMAD7 TFDP1 TFDP2 JUNB UBB WWTR1 UBC MYC RPS27A MAPK1 MAPK3 MEN1 CDK9 SMAD2 CDK8 SMAD3 SP1 CCNC SERPINE1 RNF111 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.3 Processive synthesis on the C-strand of the telomere WRN RPA3 TINF2 ACD TERF1 TERF2 POT1 TERF2IP DNA2 PCNA POLD3 POLD4 POLD1 RPA1 POLD2 BLM LIG1 FEN1 RPA2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 80%9026395 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 80%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR BIN2 ETV6 GOLGA4 KANK1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 80%211736 Stimulation of the cell death response by PAK-2p34 CASP3 PAK2 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.3 VLDLR internalisation and degradation RPS27A CLTC PCSK9 CLTA VLDLR AP2S1 MYLIP UBA52 AP2A1 AP2B1 AP2A2 AP2M1 NR1H2 NR1H3 UBB UBC BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.1 Bile acid and bile salt metabolism SLC27A2 ALB SLCO1B1 OSBPL1A SLCO1B3 ABCC3 STARD5 SLC10A1 PTGIS SLC10A2 SLC51A CYP8B1 OSBPL9 SLC51B OSBPL7 OSBPL6 OSBPL3 OSBPL2 CH25H SLCO1A2 HSD3B7 AKR1C1 AKR1D1 AKR1C3 NR1H4 AKR1C2 AKR1C4 ACOT8 CYP7B1 ABCB11 NCOA2 BAAT FABP6 CYP7A1 CYP27A1 AMACR HSD17B4 NCOA1 ACOX2 SLC27A5 CYP46A1 CYP39A1 RXRA OSBP DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 80%5678895 Defective CFTR causes cystic fibrosis PSMD8 PSMD9 PSMD6 PSMD7 RNF185 PSMD4 CFTR PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 DERL1 PSMD11 PSMD14 DERL3 PSMD13 ERLIN1 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ERLIN2 UBA52 VCP SEL1L DERL2 ERLEC1 OS9 UBB UBC RPS27A RNF5 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.1 Leishmania phagocytosis IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DOCK1 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MAPK1 IGKV3-15 IGKV3-11 MAPK3 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 NCKAP1 IGHV4-34 CYFIP1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 BRK1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 ARPC4 ARPC5 V1-3 IGKV3D-20 V5-6 FYN RAC1 ARPC2 ARPC3 IGLV3-19 VAV1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 CRK IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 NCK1 IGHV3-53 ACTR3 VAV2 V4-2 IGLC7 ACTR2 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G YES1 MYH9 NCKAP1L WASF3 WASF1 WASF2 MYO1C ELMO1 FGR BAIAP2 BTK ABI2 ABI1 HCK ACTB PTK2 VAV3 WASL SYK MYO5A MYH2 MYO10 WAS CYFIP2 WIPF1 WIPF2 WIPF3 MYO9B ABL1 ACTG1 ELMO2 NCKIPSD ARPC1B ARPC1A IGHV3-23 IGLV IGLV2-8 IGKV1-16 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 80%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.2 Autointegration results in viral DNA circles PSIP1 BANF1 HMGA1 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.1 U12 Dependent Splicing TXNL4A SNRNP35 ZCRB1 SRSF1 YBX1 PRPF6 SNRNP25 SNRNP200 PRPF8 ZMAT5 GTF2F1 GTF2F2 DDX42 SNRPD2 DDX23 SNRPD1 SNRPD3 SNRPG SNRPE SNRPF SNRNP40 SNRPB SNRNP48 LSM2 SNU13 POLR2A RNPC3 POLR2B POLR2C POLR2D POLR2E ZRSR2 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L NCBP1 SF3B4 NCBP2 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SRSF2 PDCD7 EFTUD2 SRSF6 SRSF7 CERITINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717323.1 ceritinib-resistant ALK mutants ALK EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.2 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A CDK4 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.2 Activation of G protein gated Potassium channels GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNG10 KCNJ4 GABBR2 KCNJ5 GABBR1 KCNJ10 KCNJ12 GNG12 KCNJ9 GNG11 GNG13 KCNJ15 GNB2 KCNJ16 GNB1 GNB4 GNB3 GNB5 GNGT1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 80%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 CD207 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 FCGR1A FCGR1BP PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MRC2 MRC1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 80%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production RELA NFKB2 DHX9 DHX36 MYD88 NFKB1 IRF7 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 80%69239 Synthesis of DNA ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SKP2 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME4 UBE2S PSME1 CCNE1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 RPA1 PSMC4 PSMC1 PSMC2 FEN1 CCNA2 CCNA1 DNA2 PRIM2 PRIM1 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 POLA1 POLA2 PCNA POLD3 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 POLE4 RPA3 POLE2 POLE3 SKP1 UBA52 CUL1 UBB UBC RPS27A GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 RBX1 MCM3 UBE2D1 ANAPC15 MCM4 MCM5 ANAPC16 MCM6 ANAPC10 MCM2 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.1 ponatinib-resistant FLT3 mutants FLT3 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 80%163358 PKA-mediated phosphorylation of key metabolic factors PRKACG PRKACB PFKFB1 PRKACA MLXIPL DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.1 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.2 NOD1 2 Signaling Pathway IKBKB TNFAIP3 CARD9 CASP9 TRAF6 CASP8 IKBKG ITCH MAP3K7 MAP2K6 CHUK MAPK12 MAPK13 RIPK2 UBE2V1 MAPK14 NOD1 NOD2 IRAK2 IRAK1 AAMP CASP4 UBE2N TAB3 TAB2 CYLD TAB1 MAPK11 BIRC2 CASP1 BIRC3 CASP2 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.1 SARS-CoV-2 activates modulates innate and adaptive immune responses IKBKB ATG14 NUP62 NUP214 NDC1 SEC13 NUP210 IKBKG MAP3K7 NUP133 CHUK NUP93 UBE2V1 RIPK2 NUP50 NUP54 NUP205 POM121 NOD1 NOD2 AAAS NUP160 POM121C NUP42 NUP85 SEC23A TPR NUP88 NUP43 RAE1 RANBP2 SEC24B NUP155 SEC24A UBE2N TAB3 TAB2 TAB1 SEC24D NUP153 IFNAR1 SEC24C TBK1 STING1 NUP35 B2M NUP37 TRAF6 SAR1B IL17RC IL17RA MBL2 IRAK2 PIK3C3 BECN1 HLA-H HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E PIK3R4 CREBBP TLR8 TLR7 IL17F IL17A KPNA2 PTPN6 IRAK1 NLRP3 MASP1 TLR1 TLR2 HSP90AA1 IFNA5 IFNA4 IFNA7 IFNA6 HSP90AB1 IFNA2 IFNA8 IFIH1 STAT1 TRIM4 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 SIKE1 IRF3 TRAF3 IRF7 IFNA10 JAK1 RNF135 TKFC TYK2 IFNA21 LARP1 IFNB1 ISG15 SFTPD MAVS NLRP12 G3BP1 PTPN11 G3BP2 NUP107 NUP188 CNBP STAT2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.3 Signaling by AMER1 mutants PPP2CA PPP2CB AMER1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.1 Vif-mediated degradation of APOBEC3G PSMD8 PSMD9 ELOB PSMD6 PSMD7 ELOC PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CUL5 UBA52 UBB UBC RPS27A RBX1 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 80%72689 Formation of a pool of free 40S subunits RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 80%9018677 Biosynthesis of DHA-derived SPMs ALOX15 CYP2C9 CYP2C8 HPGD LTA4H CYP2D6 ALOX12 PTGS2 CYP2E1 GSTM4 LTC4S EPHX2 CYP3A4 CYP1A1 ALOX5 CYP1A2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 80%71288 Creatine metabolism CKMT2 GATM SLC6A8 CKM CKMT1B SLC6A7 GAMT SLC6A12 SLC6A11 CKB SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 80%3232118 SUMOylation of transcription factors SUMO3 TP53BP1 SUMO2 MITF FOXL2 PIAS4 PIAS3 HIC1 SP3 PIAS1 TFAP2B CDKN2A TFAP2C MDM2 UBE2I MTA1 SUMO1 TP53 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-HSA-1474151.5 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation NOS3 SPR PRKG2 HSP90AA1 AKT1 DHFR GCHFR GCH1 PTS CALM1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 80%73762 RNA Polymerase I Transcription Initiation CCNH HDAC1 TTF1 UBTF TBP HDAC2 POLR1A POLR1B POLR1C POLR1D KAT2B POLR1E KAT2A POLR1F POLR1G POLR1H MBD3 TAF1D TAF1B GATAD2B TAF1C POLR2E GATAD2A POLR2F TAF1A RBBP4 POLR2H RBBP7 POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 CHD4 CHD3 ERCC2 MTA1 EHMT2 MTA2 RRN3 MTA3 ERCC6 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.1 Synthesis of Dolichyl-phosphate NUS1 DHDDS SRD5A3 DOLPP1 MVD DOLK DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 80%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.2 Hydroxycarboxylic acid-binding receptors HCAR2 HCAR3 HCAR1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.6 Purine ribonucleoside monophosphate biosynthesis ADSL GMPS PAICS PFAS ATIC IMPDH1 PPAT IMPDH2 ADSS1 ADSS2 GART SULFUR AMINO ACID METABOLISM%REACTOME%R-HSA-1614635.6 Sulfur amino acid metabolism CBS CTH AHCY SLC25A10 MTRR MTR APIP TXN2 GOT1 MTAP ADI1 GADL1 MRI1 CSAD ENOPH1 MAT1A ADO MPST TSTD1 BHMT2 SQOR GOT2 SUOX BHMT TST ETHE1 CDO1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.2 Truncations of AMER1 destabilize the destruction complex PPP2CA PPP2CB AMER1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.3 YAP1- and WWTR1 (TAZ)-stimulated gene expression HIPK1 TEAD1 GATA4 HIPK2 TEAD4 CCN2 TEAD2 TEAD3 KAT2B YAP1 WWTR1 NPPA TBX5 NKX2-5 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.2 Defective MMADHC causes MMAHCD MMACHC MMADHC TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-HSA-425366.3 Transport of bile salts and organic acids, metal ions and amine compounds SLC30A5 SLC11A2 SLC39A10 SLC30A1 SLC39A14 SLC40A1 CP SLC22A7 RHAG SLC16A7 SLC16A8 EMB SLC16A3 SLC16A1 SLC6A19 SLC6A18 SLC6A15 SLC22A2 SLC22A1 SLC6A14 SLC6A13 SLC6A12 SLC6A11 RUNX1 SLC6A20 SLC6A1 SLC6A2 SLC6A3 SLC5A7 SLC22A3 SLC6A5 SLC6A6 SLC6A7 RHCG SLC6A9 SLC18A1 SLC5A3 RHBG SLC22A18 SLC18A2 SLC10A6 SLC2A13 SLC11A1 SLC22A4 SLC14A1 RSC1A1 SLC14A2 SLC22A6 SLC22A5 SLC22A12 SLC13A1 SLC22A15 SLC13A2 SLC22A16 SLC13A3 SLC13A4 SLC22A8 SLC22A11 SLC47A2 SLC47A1 SLC5A11 SLC13A5 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 BSG SLC41A2 SLC41A1 SLC30A10 HEPH SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC31A1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.2 B-WICH complex positively regulates rRNA expression ACTB H3C15 DDX21 KAT2B KAT2A EP300 DEK MYBBP1A BAZ1B H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 TBP H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 H2AJ H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H H2AZ1 POLR2K H2BC9 POLR2L H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 SF3B1 H2AC20 GSK3B H3C8 ERCC6 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.3 MHC class II antigen presentation HLA-DPB1 SH3GL2 SPTBN2 KIF2A HLA-DOA HLA-DQA2 SEC13 HLA-DOB HLA-DQA1 LAG3 KIF2C KIF2B HLA-DRB5 HLA-DRB4 HLA-DQB2 HLA-DQB1 HLA-DRB3 CENPE HLA-DRB1 LGMN KIF26A CAPZA1 HLA-DRA CAPZA2 SEC23A SEC24B SEC24A SEC24D SEC24C IFI30 AP1M2 AP1M1 CLTC CLTA AP1G1 SEC31A OSBPL1A SAR1B RAB7A CTSO CTSH CTSF KIF3A CTSE RACGAP1 CTSC DNM1 DNM2 DNM3 RILP AP1B1 CTSV CTSS CTSL CTSK CD74 CTSD CAPZA3 CTSB ACTR1A CTSA ACTR1B KIF5C KIF5B KIF5A KIFAP3 KIF20A DYNLL1 DYNC1I1 DCTN6 DCTN5 KLC1 DCTN1 ACTR10 DCTN4 KLC4 KLC3 KLC2 KIF3B DYNC1I2 DCTN2 KIF3C DCTN3 ARF1 DYNC1LI1 DYNC1LI2 KIF18A KIF4B KIF4A CANX DYNC1H1 AP2S1 AP2A1 HLA-DPA1 AP2B1 AP2A2 AP2M1 KIF11 KIF15 CAPZB HLA-DMA HLA-DMB AP1S2 AP1S1 AP1S3 KIF23 DYNLL2 KIF22 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.2 Hormone ligand-binding receptors GPHB5 FSHR GNRHR CGA GNRHR2 LHCGR GPHA2 TSHB TSHR FSHB LHB GNRH2 GNRH1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 80%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists SOST LRP5 DKK1 DKK2 LRP6 DKK4 SFRP1 SFRP2 WNT4 WNT3A WNT5A KREMEN1 WNT9A KREMEN2 WIF1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 80%74751 Insulin receptor signalling cascade INSR IRS1 TRIB3 FLT3 PIK3CB PDPK1 SHC1 PIK3R4 FLT3LG GAB1 GAB2 PIK3R1 TLR9 KLB NRAS PIK3CA SOS1 AKT2 HRAS FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 GRB10 FGF9 FGF20 FGF23 FGF22 FGF10 MAPK1 IRS2 FGF19 MAPK3 PIK3C3 PIK3R2 FGFR4 THEM4 FGF16 FGF7 FGF18 INS PDE3B PTPN11 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 80%556833 Metabolism of lipids SUMO2 PIAS4 SLC27A1 SLCO1B1 MCEE SLCO1B3 HSD17B1 SLCO1A2 LPGAT1 CPNE7 PITPNB CPNE6 LCLAT1 PTGS1 PLB1 LIPI LIPH CPNE1 CPNE3 MFSD2A PCYT2 DGAT2 MIGA2 MIGA1 DGAT1 CSNK2A1 STARD7 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 PLA2G10 GPD1 SACM1L CSNK2B PLBD1 SBF1 ARF3 PLA2R1 PLA1A TNFAIP8 MTMR14 CDS1 ABHD4 GDE1 ABHD3 PIK3C2G PIK3C2B CHAT PLA2G3 TNFAIP8L1 TNFAIP8L3 PLD4 TNFAIP8L2 PLD6 PLA2G5 ENPP6 PLA2G6 SBF2 TPTE2 PLD1 RUFY1 PTPN13 PLD3 MTMR3 INPP5D PLD2 MTMR8 PGS1 PTDSS2 GDPD1 PTDSS1 GDPD3 PTPMT1 TPTE OSBPL8 GDPD5 CHKB PIK3R6 MTMR6 TMEM86B OSBPL5 INPP5K CHKA PLEKHA1 STARD10 PNPLA7 GLIPR1 PLEKHA2 DGAT2L6 PLEKHA5 CRLS1 PEMT PLEKHA6 PLEKHA3 ALPI CDS2 PLEKHA4 SYNJ2 SLC44A5 ACHE PLEKHA8 SLC44A3 PI4KB MMAA SLC44A4 PNPLA6 SLC44A1 CYP11A1 FDX1 SLC44A2 MMUT FDX2 LPCAT1 FDXR PCTP OSBPL10 ACP6 PCYT1B PLA2G4F HSD3B2 PLA2G12A CYP11B2 CYP21A2 PCYT1A PLA2G4D HSD3B1 PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PLA2G1B AGPAT1 AGPAT2 SELENOI PIP4K2A AGPAT3 PIP4K2B AGPAT4 AWAT2 PIP4K2C GPAT4 FAAH GPAT3 CYP4A22 CEPT1 CBR1 GPAT2 TRIB3 CYP4A11 FAAH2 CDIPT PTGR1 PLA2G2F PIP5K1A PTGR2 BCHE PIP5K1B CYP2U1 PLA2G2D PIP5K1C DPEP2 PLA2G2E AGK DPEP1 PNPLA8 DPEP3 MBOAT7 PTGES HPGD PLA2G2A MBOAT1 PON2 DDHD2 ALOX12B PPARG CYP4F22 MBOAT2 ALOXE3 DDHD1 ETNPPL CYP2J2 CYP4F2 GPAM CYP4F3 ETNK2 LPCAT4 CYP4B1 CYP4F8 ETNK1 LPCAT3 CYP4F11 PRXL2B LPCAT2 PNPLA3 ALOX5AP TBXAS1 CHPT1 CYP1A1 GPD1L LPIN1 LPIN2 LPIN3 PPARGC1B PNPLA2 ESRRA PPP1CB THEM4 PRKACA PTEN RORA SREBF1 CPT1A PLIN2 CLOCK NPAS2 ARNTL NR1D1 FASN ARF1 MTMR1 AKR1B1 ACSM3 ACSM6 ACADS PIP4P1 ALAS1 PLIN3 NRF1 PRKAA2 RAB4A LTA4H PRKAG2 CYP17A1 PRKAB2 LGMN CYP19A1 ALOX5 PPP1CC PPARD CYP1B1 RXRA ARNT GPX2 NCOR2 ACLY HDAC3 NCOR1 SLC27A2 TBL1XR1 SIN3A GPS2 TBL1X TXNRD1 PIK3R1 OSBPL1A LBR PPARGC1A PIK3CA MED19 OCRL MED16 MED15 MED18 MED17 MED12 MED11 MED14 MED13 MED10 PIK3C3 MED27 PIK3R2 MED26 MED29 MED28 MED23 MED22 MED25 MED24 CPT1B MED21 MED20 PPARA TSPOAP1 SCD CAV1 TIAM2 PIK3R4 ESYT1 PIK3R3 MED30 MED31 NCOA2 PTGES3 PCCA PCCB ACSL4 ACSL3 ACACB ACACA CYP46A1 CYP39A1 SP1 MTF1 CCNC SLC22A5 RGL1 VDR INPPL1 ACOXL STARD5 SLC10A1 SLC10A2 SLC51A SLC51B ECHS1 ACADM HADH MED13L CD36 NCOA1 NCOA6 NCOA3 ACADVL SREBF2 ACBD5 LTC4S CHD9 ME1 ABCC1 GPX1 LRP2 ACADL MED1 MED8 MED9 MED4 PRKACG MED6 PRKACB MED7 CDK19 AHR ARNT2 AHRR HMGCL ACSS3 BDH2 CREBBP BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 EP300 MTMR9 OSBPL9 PTGES2 MTMR7 OSBPL7 OSBPL6 OSBPL3 OSBPL2 CH25H SYNJ1 INPP5J ALOX15 RAN KPNB1 MVD CDK8 UBE2I NSDHL STARD3 ACOT9 STARD4 TGS1 MECR ACOT7 STARD6 ACOT1 HACD1 ABCB4 HACD3 HACD2 HACD4 HSD11B1 HSD11B2 FDFT1 MCAT SQLE PPT1 PPT2 SMARCD3 ACOT7L SERPINA6 TSPO ELOVL4 ELOVL6 ELOVL7 PTGIS ACSBG1 CYP8B1 ACSBG2 EHHADH ACOT6 SC5D GC DECR2 ACOT4 G0S2 TM7SF2 SLC27A3 INSIG2 INSIG1 CYP51A1 HSD3B7 ACAT2 AKR1C1 PMVK AKR1D1 THEM5 AKR1C3 NR1H4 SRD5A2 FADS2 SRD5A1 AKR1C2 ELOVL1 DHCR24 AKR1C4 ACOT8 TECRL RAB5A CYP7B1 SCP2 ABCB11 DHCR7 BAAT SLC25A1 ACSL1 ELOVL5 FHL2 PTGDS CYP7A1 ELOVL2 GGPS1 CYP27A1 ELOVL3 HMGCS1 AMACR TNFRSF21 HSD17B4 ACOX2 SLC27A5 HSD17B14 ACAA1 HSD17B13 ABCD1 FADS1 HSD17B12 HSD17B11 SLC25A20 MID1IP1 CYP2D6 ECI1 ACAD11 GGT1 SULT2A1 ACAD10 ACSL6 ACSL5 PLPP6 PTGS2 PEX11A CYP2E1 SCAP HTD2 DECR1 CIDEA CIDEC CYP2C19 STAR AKR1B15 HILPDA TECR HELZ2 ARV1 ANKRD1 STARD3NL GGT5 HSD17B3 FITM1 FITM2 HSD17B7 HSD17B8 CYP2C9 HSD17B2 CYP2C8 CBR4 OLAH RXRB GRHL1 NDUFAB1 ACAA2 MAPKAPK2 MSMO1 ACOT11 ACOT12 ACOT13 ABCC3 IDI1 IDI2 EBP MORC2 PON3 ACBD7 FDPS PON1 ACBD6 CYP3A4 ACBD4 ACSF3 ACSF2 DBI UGT1A9 CPT2 LSS MVK THRSP SEC23A AGT HPGDS SEC24B SEC24A SEC24D ALOX12 SEC24C SCD5 GSTM4 CYP1A2 PIK3CG LDLRAP1 PIK3R5 AWAT1 CUBN DHRS7B AGPS FAR1 FAR2 SAR1B ABCA1 NR1H2 PECR NR1H3 NUDT19 PHYH ACOT2 INPP5E GLTP CERK VAC14 PI4K2B HEXB MTMR10 HEXA MTMR2 HACL1 GBA3 THRAP3 MTMR12 GBA2 MTMR4 SMPD3 HAO2 SMPD2 PIK3C2A MTM1 STS INPP4A SPTLC1 SMPD4 FIG4 GM2A INPP4B EPHX2 SPTLC2 PIKFYVE INPP5F SPTLC3 PI4K2A SMPD1 OSBP FAM120B ENPP7 CERS3 CERS4 MBTPS1 APOA2 ARSA PIK3CD CERS5 PIK3CB CERS6 APOA1 SPHK2 APOA5 SPNS2 SUMF2 CYP11B1 SUMF1 ALB CROT PRKD3 CPTP PRKD2 PRKD1 ANGPTL4 PLPP3 PLPP2 MBTPS2 PLPP1 CERS1 CSNK1G2 CERS2 ASAH1 SAMD8 ASAH2 GK3P SLC25A17 PPM1L MOGAT3 SGMS1 MOGAT2 SGMS2 MOGAT1 ABHD5 NEU2 FABP12 BMX UGCG ACOX3 UGT8 LHB GK2 LIPE NEU3 AGMO ALDH3B2 GK SGPL1 FABP9 ARSL PPP1CA ALDH3B1 FABP1 ARSJ FABP2 ORMDL2 FABP3 NEU1 FABP4 ARSK FABP5 ORMDL3 CGA FABP6 PSAP FABP7 ARSH ARSI PNPLA4 ARSF PNPLA5 PLIN1 B4GALNT1 SPTSSB ARSG KDSR SPTSSA ARSD ARSB CTSA B3GALNT1 ORMDL1 NUDT7 SGPP2 CRAT SGPP1 GALC ACER2 FA2H NFYA ACER1 NFYB GLB1L VAPA NFYC GLB1 VAPB ACER3 ESYT3 ESYT2 DEGS1 DEGS2 SPHK1 GPX4 ALOX15B CARM1 GBA POMC CYP27B1 CYP24A1 CYP2R1 SRD5A3 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 80%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.3 Cargo recognition for clathrin-mediated endocytosis VAMP4 SH3GL2 GPS1 NEDD8 SH3KBP1 KIAA0319 AVP TOR1A HGS TOR1B DAB2 AAK1 SGIP1 TFRC DVL2 LRP2 CLTC FCHO1 CLTA COPS4 FCHO2 UBQLN1 EGF LDLRAP1 UBQLN2 COPS2 NECAP2 CBL SYT11 EGFR BTC PICALM LDLR AGFG1 HBEGF EREG CD3G VAMP3 CHRM2 CD3D ADRB2 SYT1 SNAP91 CLTB APOB CFTR AREG EPS15 SH3GL3 TGFA SCARB2 EPGN CLTCL1 STAM SH3GL1 GRK3 GRK2 SYT2 CD4 SYT9 SYT8 SLC2A8 EPN1 EPN2 AVPR2 ITSN2 ITSN1 COPS7B COPS7A TGOLN2 UBA52 COPS3 REPS2 COPS6 COPS5 REPS1 COPS8 TF UBB UBC M6PR IGF2R RPS27A AGTR1 IL7R NECAP1 STAM2 AP2S1 AP2A1 VAMP7 AP2B1 AP2A2 AP2M1 WNT5A VAMP2 ARRB1 STON1 ARRB2 STON2 SLC18A3 FZD4 TACR1 EPS15L1 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.2 CTNNB1 S45 mutants aren't phosphorylated PPP2CA PPP2CB AMER1 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C TRAIL SIGNALING%REACTOME%R-HSA-75158.3 TRAIL signaling TNFSF10 TNFRSF10B CFLAR TNFRSF10A TNFRSF10D CASP8 CASP10 FADD TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.2 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFRSF13C MAP3K14 TNFSF11 TNFRSF11A TNFRSF12A TRAF2 TNFSF13B CD40LG LTA TNFSF14 LTB BIRC2 TNFSF12 TRAF3 BIRC3 LTBR DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.1 Drug resistance in ERBB2 KD mutants CDC37 HSP90AA1 ERBB2 ERBIN KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.1 Keratan sulfate biosynthesis ST3GAL6 SLC35D2 B4GAT1 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 CHST6 B3GNT7 LUM B3GNT4 OGN B3GNT3 OMD CHST1 KERA B3GNT2 PRELP B4GALT6 FMOD CHST5 B4GALT4 B4GALT1 CHST2 B4GALT5 ACAN PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.1 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 80%8940973 RUNX2 regulates osteoblast differentiation YES1 MAPK1 SATB2 SP7 MAPK3 UCMA HEY1 COL1A1 HEY2 ZNF521 BGLAP SRC ABL1 CBFB YAP1 GLI3 HES1 AR RB1 MAF WWTR1 HDAC3 HDAC6 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.1 Basigin interactions SLC7A11 SLC7A10 SLC7A5 MAG SLC7A6 SLC7A9 SLC7A7 SLC7A8 L1CAM SLC3A2 SLC16A8 SLC16A3 MMP1 BSG SPN SLC16A1 PPIL2 ITGA6 ATP1B3 ITGA3 ATP1B2 ITGB1 ATP1B1 PPIA CAV1 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.1 Blockage of phagosome acidification ATP6V1H DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.3 Defective CYP27B1 causes VDDR1B CYP2R1 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 80%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer EPGN BTC AREG EGF HBEGF EREG TGFA EGFR METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.6 Metabolism of folate and pterines SHMT2 MTHFD1 MTHFD2 MTHFD2L SLC25A32 SLC19A1 DHFR MTHFR MTHFS SHMT1 FOLR2 SLC46A1 ALDH1L1 DHFR2 ALDH1L2 MTHFD1L CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.3 Chaperonin-mediated protein folding ACTB DCAF7 CCT6B CCNE2 TUBB6 TUBB3 TUBB1 FBXO4 CCNE1 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 TP53 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 XRN2 GAPDHS FKBP9 TUBA1A GNG10 GNG12 GNG11 GNG13 CCT6A CSNK2A1 GNAQ GNB2 CSNK2A2 GNB1 GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 CSNK2B FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C HDAC3 TUBA1B GNGT2 KIF13A CCT3 CCT2 VBP1 SPHK1 TUBA4A TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 GBA TUBA3E GNA14 AP3M1 TUBA3D GNA15 GNG3 TUBA3C GNG2 GNG5 GNG4 GNA11 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 STAT3 RGS11 TUBB4B TUBB4A REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 80%1433559 Regulation of KIT signaling PRKCA YES1 PTPN6 LCK LYN FYN CBL SOS1 SH2B3 SOCS1 SH2B2 SOCS6 KIT GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 80%157858 Gap junction trafficking and regulation GJD2 GJD4 GJD3 CLTC CLTA GJA1 CLTCL1 TJP1 GJA3 GJA5 GJA4 GJA9 GJA8 GJB2 GJB1 GJC1 GJC2 MYO6 GJA10 GJB4 GJB3 GJB6 AP2M1 DNM1 DAB2 GJB5 DNM2 GJB7 CLTB DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 80%2424491 DAP12 signaling BTK PIK3CB LCK FYN KLRC2 RAC1 PIK3R1 KLRD1 TYROBP NRAS PIK3CA PLCG1 SOS1 HRAS GRAP2 PLCG2 VAV2 VAV3 SYK LCP2 KLRK1 PIK3R2 TREM2 HLA-E B2M G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 80%8964315 G beta:gamma signalling through BTK GNGT2 BTK GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNG3 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.2 Receptor-type tyrosine-protein phosphatases PTPRF PTPRD SLITRK2 SLITRK1 SLITRK4 SLITRK6 SLITRK3 LRRC4B SLITRK5 PPFIA1 NTRK3 PPFIA4 PPFIA3 PPFIBP1 PPFIA2 PPFIBP2 IL1RAPL1 IL1RAPL2 PTPRS AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.2 Amplification of signal from the kinetochores INCENP ZW10 KIF2A SEC13 NUP133 KIF2C KIF2B DSN1 RCC2 ZWINT CENPE AHCTF1 CENPF TAOK1 NUP160 PPP2CA XPO1 PPP2CB NUP85 PPP1CC NDEL1 PPP2R1A NUP43 RANBP2 AURKB PPP2R5D BUB1 PPP2R1B CLASP2 CLIP1 RPS27 MAD1L1 NUP37 MIS12 DYNLL1 CKAP5 DYNC1I1 NDC80 MAPRE1 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L SPDL1 ZWILCH DYNC1LI1 DYNC1LI2 ITGB3BP CENPA KIF18A CENPC KNTC1 RANGAP1 CDCA8 CENPT BIRC5 CENPU SGO1 CLASP1 BUB1B CDC20 SGO2 SKA1 SKA2 BUB3 DYNC1H1 MAD2L1 NDE1 NSL1 PLK1 PMF1 CENPH CENPI CENPK PPP2R5E CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 PPP2R5B NUDC PPP2R5A PPP2R5C DYNLL2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 80%9025094 Biosynthesis of DPAn-3 SPMs ALOX15 ALOX12 PTGS2 ALOX5 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.2 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDKN2A CDK4 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 80%901042 Calnexin calreticulin cycle RNF103 RNF139 TRIM13 UGGT2 RNF185 UGGT1 MARCHF6 PRKCSH UBA52 GANAB SEL1L DERL2 OS9 SYVN1 EDEM2 UBB UBC RPS27A CANX MAN1B1 CALR PDIA3 EDEM3 EDEM1 AMFR RNF5 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME%R-HSA-5357956.1 TNFR1-induced NFkappaB signaling pathway IKBKB USP21 TNFAIP3 RBCK1 IKBKG MAP3K7 CHUK XIAP TNF TRAF2 USP4 USP2 RIPK1 SHARPIN TAB3 TAB2 TRADD CYLD TAB1 OTUD7B RACK1 TRAF1 TNFRSF1A BIRC2 BIRC3 RNF31 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.1 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants YES1 STAT3 LCK LYN PIK3R2 FYN STAT1 PIK3R3 PIK3R1 NRAS PIK3CA SOS1 HRAS STAT5A STAT5B KIT JAK2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.2 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding TUBA1B CCT3 CCT2 VBP1 TUBA4A TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 ACTB TUBA3E CCT6B TUBB6 TUBA3D TUBB3 TUBB1 TUBA3C CCT8 CCT7 CCT5 CCT4 TUBA4B TUBA1A TUBB4B TUBB4A CCT6A TUBA8 TUBA1C TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.2 Transport of the SLBP independent Mature mRNA NUP62 NUP214 NDC1 NXF1 SEC13 NUP210 NUP133 ALYREF NUP93 NUP50 NUP54 NUP205 EIF4E POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 NCBP1 RANBP2 NCBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 80%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) HERC2 SUMO2 RAD51B RAD51C PIAS4 RAD1 RNF168 CDK2 BLM MRE11 WRN SEM1 UBE2N RAD9B RAD9A RPA1 ATM RAD52 BABAM1 TOPBP1 BABAM2 UIMC1 ABRAXAS1 RNF8 BRCC3 TP53BP1 UBE2V2 CCNA2 SIRT6 CCNA1 DNA2 RTEL1 NSD2 H3-4 CHEK1 RNF4 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 CLSPN RFC4 RFC1 RFC2 RPA2 POLE4 RPA3 MUS81 POLE2 EME1 POLE3 EME2 POLH GEN1 SLX1B SPIDR SLX4 XRCC3 BRCA2 RAD51AP1 BRIP1 KAT5 UBE2I EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51D RAD50 RAD51 H2AX H2BC12L PPP4R2 TIPIN UBA52 H2BC21 TIMELESS PPP4C H2BU1 ABL1 H2BC17 H2BC12 H2BC13 H2BC14 HUS1 H2BC15 H2BC11 UBB UBC RHNO1 H2BC9 RPS27A ATRIP H4C9 H2BC8 H2BC5 RAD17 H2BC3 ATR H2BC1 ERCC4 ERCC1 MDC1 BRCA1 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 80%5210891 Uptake and function of anthrax toxins PDCD6IP FURIN MAP2K4 MAP2K2 MAP2K7 CALM1 MAP2K1 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 80%8964539 Glutamate and glutamine metabolism GLS2 OAT PYCR1 PYCR2 PYCR3 KYAT1 RIMKLA RIMKLB GLUD1 GLUD2 GOT2 GLS GLUL SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 80%9674555 Signaling by CSF3 (G-CSF) KRAS UBE2D3 RNF7 ELOB ELOC SHC1 STAT1 CUL5 GAB2 UBA52 HCK SOCS3 SOCS1 UBB SYK CSF3 UBC RPS27A JAK1 STAT3 GRB2 LYN TYK2 CSF3R STAT5A STAT5B PTPN11 UBE2D2 UBE2D1 JAK2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.3 Myoclonic epilepsy of Lafora RPS27A GYG1 EPM2A UBB GYS1 UBA52 PPP1R3C UBC NHLRC1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 80%73856 RNA Polymerase II Transcription Termination FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB RNPS1 CPSF4 CPSF1 CPSF3 CPSF2 CSTF2T SNRPD3 PABPN1 SNRPG SNRPE SNRPF SNRPB CLP1 SLBP CSTF3 CSTF2 CSTF1 SYMPK FIP1L1 PCF11 EIF4A3 CASC3 WDR33 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 ZNF473 LSM10 DDX39A LSM11 DDX39B NUDT21 SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 CPSF7 SRSF6 SLU7 PAPOLA SRSF7 SRSF9 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 80%1660499 Synthesis of PIPs at the plasma membrane PIP4K2C PIK3CD PIK3CB PIP5K1A PIP5K1B PIP5K1C PIK3R3 RAB4A MTMR9 BMX SYNJ1 INPP5J PTEN MTMR14 PIK3C2G PIK3C2B SBF2 RUFY1 PTPN13 PIK3CG MTMR3 INPP5D MTMR8 PIK3R5 INPPL1 PIK3R1 PIK3CA PIK3R6 MTMR6 INPP5K PLEKHA1 PLEKHA2 ARF1 OCRL PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 SYNJ2 PLEKHA8 MTMR1 RAB5A PIK3R2 PI4K2B MTMR2 PIK3C2A MTM1 INPP4A INPP4B PIP4K2A PI4K2A PIP4K2B REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.1 Regulation of signaling by NODAL NODAL LEFTY1 TDGF1P3 ACVR1B ACVR2B DAND5 ACVR1C CFC1 LEFTY2 ACVR2A CER1 TDGF1 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.3 Binding and entry of HIV virion CXCR4 PPIA CD4 CCR5 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 80%193697 p75NTR regulates axonogenesis NGFR ARHGDIA NGF OMG RHOA MAG RTN4 MCF2 LINGO1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 80%196854 Metabolism of vitamins and cofactors RBP4 CLPS RBP2 RBP1 RETSAT TCN1 RDH11 AKT1 CALM1 SLC2A1 PLB1 VKORC1L1 UBIAD1 COQ9 COQ7 COQ6 COQ5 COQ3 NNMT VKORC1 ABCC1 PDSS2 PDSS1 LRP1 LRP2 PNLIP GSTO2 DHFR LDLRAP1 CUBN AMN PRSS1 SDC4 TTR LDLR SDC2 SDC3 MTRR GPC1 GPC3 MMAA MMAB SDC1 MTR MMUT GPC2 GPC5 MMACHC MMADHC TTPA GPC4 AGRN GPC6 CTRB2 LRP10 CTRB1 BST1 LRP12 HSPG2 PRKG2 LPL FOLR2 APOE APOB GPIHBP1 COQ2 APOA2 APOC3 APOA1 APOA4 APOC2 LRP8 SLC2A3 NOS3 NAPRT SLC23A2 SLC46A1 ALDH1L1 DHFR2 SLC23A1 NADSYN1 ALDH1L2 FLAD1 NUDT12 MTHFD1 MTHFD2 MTHFD2L BCO2 PNPO BCO1 NADK SLC19A1 CBLIF SLC52A2 GCHFR SLC52A3 GCH1 IDH1 MTHFR PTS SLC5A8 SLC52A1 PC BTD MTHFS TCN2 PCCA HLCS CD320 ABCD4 PCCB ACACB MOCS2 ACACA MOCS3 QPRT GPHN NADK2 SLC22A13 HSP90AA1 NMRK2 RFK NMRK1 ACP5 CD38 AOX1 LMBRD1 NAXE PDXK MTHFD1L CYB5A NAMPT RNLS MOCOS NMNAT3 NMNAT2 NMNAT1 SLC25A32 PANK4 NAXD PANK2 THTPA PANK3 TPK1 PANK1 SLC25A19 SLC19A3 COASY SLC19A2 PPCDC SLC5A6 SLC25A16 VNN1 VNN2 SHMT1 PPCS PDZD11 FASN ENPP2 ENPP1 PTGIS ENPP3 CYP8B1 AASDHPPT PARP10 APOM PARP6 MCCC2 PARP4 PARP16 PARP9 AKR1C1 MCCC1 PARP14 SHMT2 PARP8 AKR1C3 CYB5R3 AKR1C4 GSTO1 AKR1B10 LRAT SPR PTGS2 PRSS3 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-HSA-426048.3 Arachidonate production from DAG ABHD12 DAGLA MGLL ABHD6 DAGLB DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME DATABASE ID RELEASE 80%9036092 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 80%8964011 HDL clearance HDLBP APOA1 CUBN AMN COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 80%6807878 COPI-mediated anterograde transport NSF COPZ1 NAPG ARF5 SPTBN2 USO1 COPG2 COPG1 CD59 STX5 CD55 SPTBN1 ARCN1 SPTA1 CAPZA3 CAPZA1 COPB2 CAPZA2 COPA TMED10 SPTAN1 COPB1 ACTR1A SPTB TMEM115 COPE ANK1 BET1L ARFGAP1 ARF3 RAB1A RAB1B GOLGA2 GORASP1 DYNLL1 ARF4 GOSR2 ANK2 GOSR1 DYNC1I1 DCTN6 ANK3 DCTN5 DCTN1 ACTR10 DCTN4 FOLR1 BET1 KDELR1 NAPA DYNC1I2 DCTN2 DCTN3 ARF1 TMED2 DYNC1LI1 DYNC1LI2 COG8 COG7 COG6 COG5 COG4 ARFGAP3 COG3 COG2 COG1 ARFGAP2 KDELR2 GOLGB1 KDELR3 DYNC1H1 GBF1 INS CAPZB TMED3 YKT6 TMED7 SPTBN4 TMED9 SPTBN5 COPZ2 DYNLL2 NAPB FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 80%1839126 FGFR2 mutant receptor activation POLR2A POLR2B GTF2F1 FGF1 POLR2C GTF2F2 FGF2 POLR2D FGF3 FGF4 POLR2E FGFR2 FGF6 POLR2F FGF9 POLR2G FGF20 POLR2H POLR2I FGF23 POLR2J FGF22 POLR2K FGF10 POLR2L FGF16 FGF7 NCBP1 NCBP2 FGF18 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 80%167044 Signalling to RAS NGF SHC1 MAPK12 MAPK13 SHC2 SHC3 NRAS MAPKAPK3 NTRK1 MAPKAPK2 RALGDS SOS1 HRAS RALA MAPK14 RALB MAPK11 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.1 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.1 WNT mediated activation of DVL DVL2 CSNK2A1 DVL3 CSNK1E CSNK2A2 PIP5K1B CSNK2B DVL1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 80%8941858 Regulation of RUNX3 expression and activity PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 SRC PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 EP300 PSME1 PSME2 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 RUNX3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 TGFB1 CDKN2A PSMC5 PSMC6 PSMC3 MDM2 CBFB PSMC4 PSMC1 PSMC2 UBA52 SMURF2 UBB SMURF1 UBC RPS27A CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 80%389357 CD28 dependent PI3K Akt signaling MAP3K8 CD86 MTOR TRIB3 PDPK1 LCK CD80 MAPKAP1 PIK3R2 CD28 MAP3K14 THEM4 FYN AKT3 PIK3R3 PIK3R1 PRR5 PIK3CA AKT2 MLST8 AKT1 RICTOR DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 80%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 80%166016 Toll Like Receptor 4 (TLR4) Cascade RPS6KA2 IKBKB RPS6KA1 ATF1 SIGIRR IKBKG MAP3K7 MAP2K6 TICAM2 CHUK MAPKAPK3 MAPKAPK2 CD180 UBE2V1 RIPK2 IRAK3 NOD1 NOD2 PPP2CA RELA PPP2CB MAPK1 MAPK3 PTPN4 NFKB1 NFKBIA MAP2K3 UBE2N TAB3 TAB2 TAB1 NFKBIB TBK1 MAPK11 TRAF6 LY86 LBP ITGAM SOCS1 ITGB2 MAP2K1 TNIP2 MAP3K8 IRAK2 BPI DNM1 DNM2 DNM3 ATF2 BTK S100A9 S100A8 MAP2K4 MAPK14 PLCG2 MAP2K7 JUN FOS MAPK9 MAPK8 MAPK10 IRAK1 PELI3 PELI2 PELI1 PPP2R1A LY96 CD14 S100A1 MYD88 DUSP4 BTRC DUSP3 TIRAP PPP2R5D TLR1 VRK3 DUSP6 TLR6 DUSP7 TLR4 MAPK7 PPP2R1B IRAK4 TLR2 SKP1 FBXW11 APP FGB UBE2D3 FGA HMGB1 CASP8 FGG UBA52 NKIRAS1 NKIRAS2 IKBKE TICAM1 CUL1 ELK1 CREB1 UBB IRF3 TRAF3 IRF7 UBC RPS27A AGER TANK S100A12 CD36 RIPK1 ECSIT FADD RIPK3 MAP3K1 S100B NFKB2 SAA1 PTPN11 UBE2D2 UBE2D1 MEF2A BIRC2 MEF2C BIRC3 RPS6KA3 RPS6KA5 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 80%597592 Post-translational protein modification BMI1 HERC2 SUMO3 SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 NUP210 RING1 NUP133 PARP1 NSMCE3 NSMCE2 NSMCE1 SMC1A PIAS1 NUP93 RNF168 EID3 NSMCE4A NUP50 NUP54 SP100 NUP205 POM121 BLM XPC AAAS NUP160 RNF2 HDAC7 WRN POM121C NUP42 PIGS NUP85 LY6K RAD21 TDG CPM PIGU TPR PGAP1 NUP88 PIGT NUP43 PIGO RAE1 PSCA RANBP2 PIGN CBX8 GPAA1 PHC2 PIGP PHC1 PIGZ XRCC4 MSLN NUP155 PIGW CBX4 PIGV CDKN2A PIGY CBX2 PRSS21 PCGF2 PIGX RPA1 FCGR3B ALG2 NUP153 PRND PHC3 TECTA PML TECTB RAD52 CD52 STAG1 STAG2 PLAUR CAMKMT NUP35 IZUMO1R ARF3 NUP37 RTN4RL2 PIGC MUCL1 DPM1 DPM2 PIGB DPM3 CEACAM7 NRN1L RTN4RL1 CEACAM5 CD109 PIGA LY6D PIGK PIGM SPACA4 PIGL PIGG LY6H PIGF GPLD1 PIGH LY6E NRN1 NTM TEX101 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 ART4 LYPD8 OTOA LY6G6C LY6G6D UBA2 OPCML NTNG1 SAE1 NTNG2 CNTN5 NEGR1 LSAMP GP2 PLET1 BST1 PRSS41 XPNPEP2 RAET1G LYPD6B RAET1L ALPL CNTN3 MELTF CNTN4 FOLR2 PDIA3 ULBP2 MDGA2 ALPG RECK MDGA1 SPRN TRIM27 PPARG NR3C2 PCNA SUZ12 USP18 RNF146 SMAD1 TNKS FOXO4 BGLAP PTEN CHD3 DPAGT1 ALG8 ALG9 ALG6 USP13 ALG14 MTA1 ALG13 ALG3 TNKS2 ALG12 ALG1 BARD1 MPDU1 RFT1 OTUD3 GOLGA2 DNMT3A VNN1 VNN2 SMAD4 ARF1 FGF23 DDB2 CUL4A DDB1 CHM CUL4B ING2 TAF9B NSF HIPK2 SQSTM1 RIPK2 IGFBP3 NOD1 NOD2 RRAGA CALR RARA TGFB1 TGFBR1 TGFBR2 RXRA RABGGTB RABGGTA SNX3 TAF10 PPARGC1A TMED2 TRRAP RAB7A LMAN1 PPARA YKT6 ST6GALNAC1 CMAS NPL NANP USP8 EDEM3 NEU4 EDEM1 SLC17A5 ST8SIA5 AMFR RNF5 ST3GAL5 ST8SIA6 RNF103 ST3GAL6 RNF139 TRIM13 NANS YY1 ST6GAL2 UGGT2 ST8SIA1 RNF185 USP34 ST8SIA3 UGGT1 ST6GALNAC5 MARCHF6 ST6GALNAC6 GNE UBA6 UBE2Z FUT3 UBE2L3 UBE2Q2 USP7 UBE2H USP5 UBE2B USP9X B4GALNT2 UBE2E3 SENP5 UBE2G1 SENP2 UBE2A UBE2G2 UCHL3 UBE2W UBE2R2 UBE2T SPTB OTULIN UBA1 PGR DDX5 APC SERPINC1 PROS1 AXIN1 KNG1 RCE1 ICMT FGA F10 SERPIND1 ARF4 ANK2 USP17L2 ANK3 FGG F2 F5 F7 F8 EPAS1 PROC F9 PROZ ST8SIA4 TFG WDR48 DTL ST8SIA2 RAD18 RWDD3 PRMT3 ETFB METTL21A KIN METTL22 EEF2KMT ETFBKMT GBF1 NCOA1 VCPKMT EEF1AKMT2 RAB11A EEF1AKMT1 NR5A1 COPZ2 COPZ1 ARF5 USP15 NEDD8 USO1 LTBP1 LMAN2 EEF1A1 CHML UCHL5 SMAD7 TRAPPC10 ARCN1 RAB43 SPTA1 RAB41 RAB32 RAB30 RAB36 RAB35 RAB38 RAB6B TRAPPC2 SEC16B TRAPPC3 RPS2 TRAPPC4 SEC16A TRAPPC5 TRAPPC9 EEF2 CNIH1 CNIH2 CNIH3 MCFD2 PPP6R1 BET1L ARFGAP1 SEC22A SEC22C RAB1A RAB1B PPP6C PPP6R3 RAB21 CCNA2 CCNA1 RAB12 FOLR1 BET1 KDELR1 MANEA CHST10 CHST8 MGAT3 GALNT11 GALNT14 GALNT13 COG8 GALNT16 COG7 GALNT15 COG6 GALNT18 LMAN1L GALNT17 COG5 GALNT10 POFUT2 COG4 LARGE2 COG3 B3GALNT2 COG2 GALNTL5 COG1 PREB GALNTL6 ANKRD28 B3GNTL1 GALNT9 KDELR2 GALNT8 KDELR3 POMGNT2 B3GNT9 B3GNT8 LMAN2L B3GNT6 B3GNT5 CHST4 RAB39A GCNT1 RAB39B RAB27B GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 MIA2 GALNT4 A4GNT TMED3 POMK TMED7 RAB8B TMED9 RAB33A RAB33B RAB7B NAPB HIF3A STX17 ELOB NAPG ELOC RAB11B SEC23IP COPG2 COPG1 SEMA5A TRAPPC2L TBC1D20 CDH2 COPB2 COPA TMED10 MAN2A2 MITF FOXL2 HIC1 SP3 CUL2 DOLPP1 MVD SMAD2 TMEM115 SMAD3 COPE MAN1A2 WDR61 MAN1A1 WDR5 TRAPPC6A TRAPPC6B GORASP1 GOSR2 GOSR1 GATA3 MAN1C1 GALNT2 OGT RBBP5 CBX5 RAB5A DAG1 CAPZB SPTBN4 SPTBN5 NFE2L2 SPTBN2 SIAH2 HDAC2 CAPZA1 CAPZA2 MYC HGS COP1 MDM2 MDM4 UBXN1 BABAM1 PMM1 BABAM2 DDA1 UIMC1 PTRH2 CASP8AP2 ABRAXAS1 MBD1 SPSB3 BRCC3 CCDC8 NUDT14 TP53BP1 UAP1 ATXN7 AMDHD2 NAE1 PCSK9 GFPT2 PGM3 COMMD10 BAP1 TOP1 UHRF2 FEM1C FEM1A FEM1B NAGK ALG5 COMMD8 COMMD2 COMMD1 COMMD6 SAR1B COMMD7 COMMD4 COMMD5 VDAC3 STAMBPL1 NR1H2 VDAC2 ENGASE VDAC1 SPON2 NGLY1 MYSM1 SEMA5B SPON1 ERCC8 THSD7B DCAF8 B3GLCT DCAF5 DCAF4 THBS2 ADAMTS12 DCAF6 USP17L4 THBS1 USP17L5 THSD1 USP17L8 THSD4 ADAMTS10 DDX17 WSB2 ADAMTSL1 RHOA ADAMTS15 ALG10B CDC20 TADA2B ADAMTS2 ADAMTS14 ZNF131 ASGR1 ADAMTS3 USP33 ADAMTS13 ASGR2 IL6 ADAMTSL5 FN3KRP ADAMTSL4 WDR20 ADAMTS19 USP17L3 ADAMTSL3 USP17L1 ADAMTSL2 USP3 ADAMTS17 FKBP8 THSD7A STAMBP CUL9 ADAMTS6 WDTC1 ADAMTS7 SBSPON FN3K SSPOP TADA3 ADAMTS20 CCDC22 TULP4 STS DCAF16 CDC73 DCAF17 CTR9 DCAF10 DCAF11 RTF1 USP17L30 OBSL1 DCUN1D5 DCUN1D3 LEO1 DCUN1D4 DCUN1D1 DCUN1D2 ARSA PAF1 UMOD DPH1 DPH2 DPH3 DPH5 SUMF2 DPH6 SUMF1 DPH7 PUM2 TOP2B ANKRD9 GNPNAT1 RENBP USP17L21 USP17L20 USP17L22 USP17L15 USP17L18 USP17L17 USP17L19 SATB1 USP17L10 USP17L12 USP17L11 USP17L13 NEU2 ALG10 CLSPN DNAJC24 LHB UBD NEU3 USP37 GMPPB GMPPA ARSL USP47 USP48 ARSJ USP49 USP42 NEU1 USP44 ARSK SAFB USP14 CGA USP16 ARSH USP12 ARSI ABRAXAS2 ARSF USP19 USP24 USP25 ARSG USP26 USP20 USP22 ARSD USP28 ARSB NEURL2 CTSA GLB1 ST6GALNAC2 RPN2 TUSC3 PRKCSH RPN1 MAGT1 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS DDOST HNRNPK MGAT4C DAD1 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 B4GALT1 INS LRR1 CCNF KEAP1 FBXO7 FBXO9 WSB1 FBXO2 RNF123 UBE2J2 GRIA1 FBXL8 FBXL4 FBXL7 SLC35A1 SLC35C1 GAN B4GALT2 CALM1 B4GALT3 KLHL2 KLHL3 KLHL9 SPSB2 B3GNT7 SPSB1 B3GNT4 B3GNT3 KBTBD6 KLHL5 B3GNT2 B4GALT6 KBTBD8 SPSB4 B4GALT4 B4GALT5 FBXO27 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 MUC13 FBXO15 LMO7 FBXO10 FBXO11 GGCX KLHL41 KCTD6 AXIN2 KCTD7 KLHL42 UBE2V2 CUL7 CUL5 CKAP4 KTN1 KLHL11 KLHL13 FBXO44 FBXO41 SOCS3 FBXO40 BTBD1 UBE2F ALPI KLHL25 SMURF2 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO32 FBXO30 FBXO31 PARK7 TTLL10 KLHL20 TPGS1 TTL TPGS2 TUBB8 UBA3 SVBP AGTPBP1 LRRC49 NICN1 UBE2M TUBB8B VASH2 VASH1 TTLL7 KBTBD13 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 USP30 TTLL2 TTLL1 AGBL3 AGBL2 TTLL13 TTLL11 ASB13 TTLL12 TTLL9 ASB14 TTLL8 ASB11 GMDS ASB12 FCSK RNF7 FPGT FUOM ASB17 GFUS ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 FBXL19 DCAF13 FBXL18 NOP58 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 PNPLA2 ASB6 ASB7 CETN2 ASB4 CCP110 ASB5 ASB2 ACTR1A ASB3 TUBA1A ASB1 BTRC RAB8A SKP1 FBXW11 RORA NR3C1 CSNK1D DYNLL1 HIF1A UBA52 NRIP1 DYNC1I2 DCTN2 MRTFA DCTN3 CUL1 AURKA AR DYNC1LI1 DYNC1LI2 UBB CTBP1 UBC CDCA8 RPS27A USP4 USP2 DYNC1H1 RHOT1 TUBB4B TUBB4A HNRNPC CDK1 OTUD7B RBX1 BIRC2 BIRC3 DYNLL2 LRRC41 USP21 PSMD8 INCENP PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 GPS1 PSMD1 IKBKG MAP3K7 RAB4A RAB13 PSMA5 PSMA6 PSMA3 PSMA4 STX5 FUCA1 PSMA1 FUCA2 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BCL10 PSMA7 RELA PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 MEN1 PSMF1 PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CISH NCOR2 HDAC1 SIN3A HSP90B1 COPS4 COPS2 ARFGAP3 RANGAP1 ARFGAP2 BIRC5 MUC5AC ADAM10 BECN1 RNF20 ADAMTS16 ADAMTS18 GALNT12 POMT2 CFTR POMT1 C4A C1GALT1C1 LAMC1 LARGE1 POMGNT1 C1GALT1 B4GAT1 ADAMTS4 ADAMTS5 ADAMTS1 SCFD1 TRIM28 SPTBN1 STAM TIMP1 ADAMTS8 ADAMTS9 RAB27A HDAC4 L3MBTL2 SATB2 ZBED1 SPTAN1 NCOA2 FURIN EIF5A MUC12 DHPS MUC15 EIF5A2 SPP1 DOHH LAMB1 TNC DMP1 LGALS1 EVA1A CCN1 CHGB IGFBP1 IGFBP5 IGFBP4 APLP2 VDR SHISA5 H2AC19 PDIA6 MXRA8 DYNC1I1 SPARCL1 H2AC14 SCG3 SCG2 TGOLN2 ACTR10 H2BC21 STC2 RUVBL1 PENK IGFBP7 H2BU1 AMELX WFS1 RAB9A H2AC8 AMBN H2AC6 TMEM132A RAB9B H2AC7 BMP4 TF MUC3A H2BC17 CALU MUC3B H2BC12 HRC H2BC13 FBN1 H2BC14 SERPINA10 MIA3 H2BC15 CHRDL1 H2BC11 PRSS23 BMP15 MUC16 ANO8 MUC17 MEPE MUC19 RCN1 RBBP7 VGF ENAM H2BC9 AMTN VWA1 MUC20 FAM20C NPM1 MUC21 FAM20A MFGE8 H4C9 H2BC8 GAS6 MATN3 ITIH2 STAM2 H2BC5 AFP FSTL1 H2BC3 FSTL3 SPP2 H2BC1 APOL1 LAMB2 GOLM1 ZNF350 H2AC20 NUCB1 CAND1 NOTUM MUC5B UBE2D2 UBE2D1 PRKDC CFP H2AW H2AC17 CDC34 H2AC12 H2AC1 H2BC18 AHSG H2AC21 POLB SENP1 RAB3A CSF1 RAB3D MUL1 RAB44 NPLOC4 AURKB UBE2N VHL UBXN7 UFD1 TAB1 RAB31 RAB37 RAB5B RAB5C RAB6A RAB4B TRAPPC1 TRAF6 TOP2A COL7A1 RAB24 RAB10 TNIP2 RAB18 ADRB2 NR4A2 THRB HLA-B HLA-A NR2C1 RAB3B RAB3C RAB22A RAB42 RAB2A MLEC RAB2B PTP4A2 RAB34 RAB40A RAB40B RAB20 RAB40C RAB25 CREBBP RAB26 RAB23 RAB29 RAB15 RAB19 RAB17 KAT2B RNF152 KAT2A CST3 SHPRH EP300 PEX2 RNF40 RNF144A SELENOS WAC CAPZA3 DERL1 IL33 TMEM129 TP53 HLTF PEX10 PEX12 PEX14 RNF181 GALNT3 COPB1 CUL3 PIAS3 TOPORS NLRP3 KBTBD7 C3 KDM1B TFAP2B TFAP2C UBE2I SUMO1 OTUD5 APP NFRKB ACTR5 ACTL6A UBE2D3 ACTR8 MUC1 INO80C TNFAIP3 INO80B MUC2 INO80E MUC7 INO80D COPS7B COPS7A IFIH1 DNMT3B TFPT MUC4 MCRS1 TRIM4 INO80 COPS3 MUC6 COPS6 COPS5 TRIM25 COPS8 IKBKE NUS1 DHDDS TOMM70 DDX58 DNMT1 TRAF2 OTUB2 OTUD7A VCPIP1 TRAF3 ZRANB1 YOD1 SUDS3 TNIP1 RNF128 TNIP3 OTUB1 GALNT1 RNF135 USP10 RIPK1 NFKB2 CYLD MAVS UBE2K CP SKP2 DAXX DNAJC3 UBE2C UBE2E1 SOCS2 UBE2S SOCS6 SOCS5 SEC22B SEC23A SEC24B TPST2 SEC24A TPST1 SEC24D SEC24C COMMD9 MAT2B SEC31A PRKN ATXN3 ATXN3L VCP RAD23A JOSD2 JOSD1 SEL1L RAD23B DERL2 OS9 SDC2 BPIFB2 SYVN1 TOMM20 VCAN GPC3 CTSZ QSOX1 CDC25A CTSC COMMD3 APOE APOB GPIHBP1 MBTPS1 APOA2 APOA1 AREG IDE APOA5 ALB P4HB TGFA CD59 ACTB CD55 ESR1 DCAF7 TUBB6 TUBB3 TUBB1 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 HSPA8 ANK1 FBXL3 FBXL5 UCHL1 SENP8 HCFC1 TUBA1C FOXK2 TUBA1B FOXK1 MBD5 MBD6 ADRM1 ASXL1 ASXL2 TUBB2B DCTN6 TUBB2A DCTN5 DCTN1 DCTN4 USP11 TUBA3E NAPA TUBA3D GFPT1 TUBA3C GOLGB1 ALG11 SERPINA1 ARRB1 ARRB2 MDC1 NUP107 SRD5A3 NUP188 FN1 MPI SMC5 PMM2 SMC6 BRCA1 DOLK SMC3 GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.1 Glycogen metabolism AGL UGP2 UBA52 PYGB EPM2A GBE1 GAA GYS2 UBB GYS1 CALM1 PPP1R3C UBC PGM1 NHLRC1 GYG2 RPS27A GYG1 PYGM PHKB PHKA1 PHKA2 PGM2L1 PHKG1 PHKG2 PGM2 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.1 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R40 TAS2R41 SCN9A TAS2R8 PLCB2 TAS2R20 TAS2R43 TAS2R46 ITPR3 GRM4 GNAT3 TAS2R1 TAS1R2 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 TAS2R30 SCN3A TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 TAS2R16 TAS2R39 SCN2A SCN2B GNG13 SCN4B TRPM5 GNB1 TRPM4 CALHM1 GNB3 CALHM3 SCN1B TAS2R7 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-HSA-380270.2 Recruitment of mitotic centrosome proteins and complexes CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A TUBGCP2 PPP2R1A CNTRL CEP250 TUBGCP5 NEK2 TUBGCP6 TUBGCP3 PRKACA TUBGCP4 NINL CEP290 YWHAG CDK5RAP2 TUBG2 MZT2B OFD1 MZT2A HSP90AA1 NME7 CEP135 CDK11A TUBB CEP131 CDK11B HAUS4 MZT1 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 80%9754706 Atorvastatin ADME SLCO1B3 ABCB1 PON3 ABCC2 PON1 CYP3A4 SLCO1B1 UGT1A3 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.5 Signaling by ROBO receptors RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A SRC RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 LDB1 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 CLASP2 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 SLIT1 RPL26L1 RPS24 RPS23 SLIT3 SLIT2 HOXA2 COL4A5 PRKACG PRKACB EIF4A3 CASC3 MAGOH NCBP1 NCBP2 PRKAR2A UPF3A ELOB RBM8A ELOC UPF3B MAGOHB RNPS1 FLRT3 CUL2 PRKACA LHX3 LHX2 LHX4 LHX9 UBA52 ABL1 UBB UBC RPS27A CLASP1 DAG1 RBX1 PSMD8 PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 VASP PSMD1 PSMA5 PSMA6 PSMA3 ROBO2 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 ROBO1 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 RPS6 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 EIF4G1 PSMC5 CXCR4 PSMC6 AKAP5 PSMC3 PSMC4 PSMC1 PSMC2 ARHGAP39 SRGAP3 CDC42 PAK1 SRGAP1 ISL1 RAC1 PAK3 PAK2 SOS1 NCK2 NCK1 GPC1 UPF2 RHOA EVL SOS2 USP33 DCC ABL2 SRGAP2 ZSWIM8 PAK4 MSI1 PFN1 PFN2 CXCL12 ETF1 NRP1 NTN1 NELL2 PAK6 PAK5 MYO9B GSPT2 GSPT1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 PPP3CB RPL10L RPLP0 CAP1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 ENAH RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL CAP2 RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 80%381038 XBP1(S) activates chaperone genes YIF1A HDGF TPP1 TLN1 ATP6V0D1 SULT1A3 GSK3A GOSR2 PDIA6 CUL7 SHC1 SRPRA DCTN1 SERP1 SRPRB SEC31A DNAJC3 WFS1 GFPT1 SYVN1 ADD1 PREB KDELR3 PLA2G4B ACADVL FKBP14 MYDGF TATDN2 TSPYL2 DDX11 SSR1 PDIA5 WIPI1 CTDSP2 LMNA DNAJB11 CXXC1 HYOU1 EXTL2 PPP2R5B EXTL1 ARFGAP1 DNAJB9 EXTL3 EDEM1 ZBTB17 KLHDC3 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.1 Cell recruitment (pro-inflammatory response) HSP90AB1 RELA ENTPD1 HMOX1 NLRP3 C3AR1 ENTPD5 PSTPIP1 GSDMD NFKB1 C3 TXNIP PYCARD NFKB2 CTSG IL18 SUGT1 IL1A IL1B MEFV P2RX7 CASP1 P2RX4 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.1 Striated Muscle Contraction TMOD3 ACTN2 TMOD1 ACTN3 TMOD4 TMOD2 MYL4 MYL1 MYL2 MYL3 TPM2 TPM1 NEB MYBPC3 MYBPC1 MYBPC2 TPM4 TNNC1 TPM3 TNNC2 MYH3 TNNT1 TNNT2 TNNT3 MYH8 MYH6 TTN TNNI1 TNNI2 DES DMD TCAP TNNI3 VIM FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.1 FGFR3 ligand binding and activation GALNT3 FGF1 FGF16 FGF2 FGF18 FGF4 FGF9 FGF20 FGF23 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 80%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%190377 FGFR2b ligand binding and activation FGF22 FGF10 FGFBP3 FGFBP1 FGFBP2 FGF1 FGF2 FGF7 FGF3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.2 Regulation of actin dynamics for phagocytic cup formation IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DOCK1 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MAPK1 IGKV3-15 IGKV3-11 MAPK3 V2-8 IGHG3 V1-20 CFL1 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 FCGR1A IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 FCGR2A IGKV3-20 NCKAP1 IGHV4-34 CYFIP1 IGHV1-2 LIMK1 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 BRK1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 PAK1 ARPC4 ARPC5 V1-3 IGKV3D-20 V5-6 RAC1 ARPC2 ARPC3 IGLV3-19 VAV1 IGKV2-30 IGHV2-70 NF2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 CRK IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 NCK1 IGHV3-53 ACTR3 VAV2 V4-2 IGLC7 ACTR2 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G MYH9 NCKAP1L WASF3 WASF1 WASF2 MYO1C ELMO1 BAIAP2 BTK ABI2 ABI1 ACTB PTK2 VAV3 WASL SYK MYO5A MYH2 MYO10 HSP90AA1 WAS HSP90AB1 CYFIP2 WIPF1 WIPF2 WIPF3 MYO9B ABL1 ACTG1 ELMO2 NCKIPSD ARPC1B ARPC1A IGHV3-23 IGLV IGLV2-8 IGKV1-16 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 80%933542 TRAF6 mediated NF-kB activation IKBKB HMGB1 IFIH1 TRAF6 IKBKG TRIM4 CHUK NKIRAS1 NKIRAS2 TRIM25 DDX58 TRAF2 RELA AGER RNF135 S100A12 NFKB1 MAP3K1 NFKBIA S100B NFKB2 MAVS SAA1 NFKBIB APP SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.2 Signaling by RNF43 mutants WNT3A LRP5 LRP6 FZD5 RNF43 FZD4 FZD6 FZD8 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 80%176408 Regulation of APC C activators between G1 S and early anaphase ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 FBXO5 CCNA2 CCNA1 UBA52 CUL1 CCNB1 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 PLK1 CDK1 UBE2D1 ANAPC15 ANAPC16 ANAPC10 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 80%168277 Influenza Virus Induced Apoptosis TGFB1 SLC25A6 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.1 NOTCH4 Intracellular Domain Regulates Transcription ACTA2 HEY1 HEY2 HES5 NOTCH2 CREBBP NOTCH1 MAML2 NOTCH4 MAML1 FLT4 RBPJ SMAD3 KAT2B KAT2A SNW1 EP300 HES1 MAML3 MAMLD1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 80%164939 Nef mediated downregulation of CD28 cell surface expression AP2M1 CD28 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.3 NEP NS2 Interacts with the Cellular Export Machinery NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 XPO1 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAN RAE1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME%R-HSA-9005895.1 Pervasive developmental disorders NCOR1 TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X CALM1 NCOR2 PRKACA HDAC3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.2 Transcriptional regulation of pluripotent stem cells SALL4 LIN28A SOX2 STAT3 POU5F1 ZIC3 FOXD3 TDGF1 PRDM14 DPPA4 ZSCAN10 EPHA1 SMAD2 SMAD4 NR5A1 EPAS1 PBX1 NANOG FGF2 SALL1 HIF3A KLF4 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 80%9725370 Signaling by ALK fusions and activated point mutants IRS1 VCL SQSTM1 RNF213 EEF1G STRN EIF2AK3 BIRC6 BCL2A1 BCL11A ZC3HC1 RRBP1 WDCP RPS6 EML4 PPM1B MAPK1 MAPK3 GRB2 TPR RANBP2 TPM4 TPM3 CEBPB SKP1 ATIC PPFIBP1 KIF5B LMO7 CLTC DCTN1 KLC1 PIK3R1 SEC31A PIK3CA GCC2 CARS1 PLCG1 JUNB FRS2 CUL1 FRS3 TFG NPM1 STAT3 PRKAR1A MSN MYH9 HIP1 STAT5A ALK RBX1 FN1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 80%5661270 Formation of xylulose-5-phosphate CRYL1 XYLB DCXR AKR1A1 SORD RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013405 RHOD GTPase cycle VANGL1 ARHGAP32 DIAPH3 DIAPH1 ESYT1 LMNB1 AKAP12 FILIP1 HINT2 MOSPD2 ADD3 GOLGA8R RHOD SLC4A7 DBN1 ARHGAP1 VAPB ARHGAP39 ARHGAP5 PLXNA1 ARHGAP35 PAK6 PAK5 STBD1 PIK3R1 EMD PLXNB1 LBR ANKFY1 TMPO EFHD2 STEAP3 VRK2 LEMD3 DEPDC1B RAB7A VAMP3 PIK3R2 ARHGAP17 LMAN1 ARHGAP21 PGRMC2 RACGAP1 TOR1AIP1 ARHGAP12 WHAMM CAPZB CPNE8 CAV1 MCAM ACTN1 ARHGAP26 SDK INTERACTIONS%REACTOME%R-HSA-373756.2 SDK interactions SDK1 SDK2 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.2 LXR-mediated signaling NCOR1 TNRC6B TBL1XR1 KDM4A GPS2 TBL1X APOC2 MOV10 ANGPTL3 MYLIP RXRB UGT1A3 NRIP1 ABCG1 APOD FASN EP300 ABCA1 NR1H2 APOC4 PCK1 NR1H3 APOC1 AGO3 FABP6 AGO4 AGO1 AGO2 NCOA1 PLIN1 KDM3A KDM1B ABCG8 ABCG5 ARL4C EEPD1 CETP KDM1A RXRA SCD TNRC6C APOE NCOR2 TNRC6A HDAC3 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 80%5660668 CLEC7A inflammasome pathway RELA MALT1 IL1B CASP8 NFKB1 PYCARD ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 80%1236975 Antigen processing-Cross presentation IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 IKBKG CHUK PSMA5 LNPEP PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 TAP2 PSME1 PSME2 TAP1 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SEC22B PSMB10 PSMA8 PSMB6 PSMB7 STX4 PSMB4 PSMB5 PSMB2 PSMB3 CALR PSMB1 PSMF1 FCGR1A FCGR1BP PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NCF1 NCF2 SNAP23 NCF4 B2M CYBB ITGB5 CYBA VAMP3 HLA-H HLA-B PDIA3 HLA-C HLA-A HLA-F HLA-G HLA-E BTK CTSV CTSS SEC61G SEC61B S100A9 S100A8 CTSL CD207 ITGAV LY96 CD14 S100A1 MYD88 TIRAP TLR1 TLR6 TLR4 TLR2 SEC61A2 SEC61A1 FGB FGA HMGB1 FGG UBA52 UBB UBC RPS27A CD36 TAPBP MRC2 MRC1 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 80%9673324 WNT5:FZD7-mediated leishmania damping DVL2 MAPK8 DVL3 WNT5A NOXO1 CYBA FZD7 NOXA1 RAC1 JUN NOX1 DVL1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.2 Infection with Mycobacterium tuberculosis TRIM27 GSK3A RNF213 UBA52 NOS2 LTF CTSG UBB UBC RAB7A RPS27A MAPK1 PGK1 MAPK3 RAB5A ENO1 DUSP16 KPNB1 VPS33B CORO1A ATP6V1H HGS KPNA1 TLR2 MRC1 SFPQ B2M HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.3 Hydrolysis of LPE PLA2G4C GPCPD1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.1 tandutinib-resistant FLT3 mutants FLT3 VIRAL MRNA TRANSLATION%REACTOME%R-HSA-192823.4 Viral mRNA Translation RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A GRSF1 RPSA DNAJC3 RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.1 Defective APRT disrupts adenine salvage APRT SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 80%2428933 SHC-related events triggered by IGF1R SOS1 IGF1R HRAS IGF2 IGF1 NRAS CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 80%1280215 Cytokine Signaling in Immune system KRAS CCL19 CCL22 NUP62 NUP214 CCL20 NDC1 SEC13 NUP210 CAMK2B NUP133 CAMK2D CAMK2A PIAS1 NUP93 NUP50 NUP54 SP100 NUP205 POM121 AAAS NUP160 CAMK2G CSF1R POM121C NUP42 NUP85 NDN TPR NUP88 NUP43 RAE1 XAF1 RANBP2 EIF4G3 EIF4G2 FCGR1BP EIF4E3 NUP155 IL3RA EIF4E2 NUP153 PML NUP35 B2M NUP37 PDE12 MAOA EBI3 PTPN13 CUL5 INPP5D SOCS3 IFNLR1 SOCS1 IL17RE IL17RC IL17RB IL17RA OPRD1 IFI6 EIF4A3 UBA3 UBE2M BATF ATF2 CSF2RB RNF7 CSF2RA FLT3 AKT3 EGR1 CXCL8 CXCL1 CXCL2 GRAP2 MAP2K4 OPRM1 MAP2K7 USP41 JUN USP18 S1PR1 SYK NEDD4 FOS LTBR MAPK9 ABCE1 MAPK8 KPNA2 MAPK10 IRS2 FOXO1 PPP2R1A MYD88 BTRC PRKACA IRAK4 SKP1 HSP90AA1 FBXW11 RORA CASP1 HIF1A STAT1 UBA52 PRKCD ARF1 CUL1 ANXA1 RALA PITPNA FPR1 FGF2 BOLA2B CNN2 UBB CA1 HNRNPDL STAT4 IL12B IL12A UBC IL12RB1 IL12RB2 JAK1 RPS27A HSPA9 SERPINB2 ANXA2 GSTO1 AIP MSN TYK2 MIF BCL2L11 SOD2 SOD1 MTAP VAMP7 IFNG GSTA2 HNRNPA2B1 PDCD4 SNRPA1 LCP1 STAT5A PPIA FASLG STAT5B CSH1 PTPN11 PRL PRLR RBX1 TNFRSF1A MEF2A BIRC2 GH2 MEF2C BIRC3 GHR RPS6KA3 GH1 JAK2 RPS6KA5 IKBKB RPS6KA2 PSMD8 RPS6KA1 PSMD9 IL1RN ATF1 PSMD6 IL18RAP PSMD7 IL36A PSMD4 IL36B PSMD5 IL1R1 PSMD2 IL1R2 SLA2 PSMD3 SIGIRR PSMD1 SQSTM1 IKBKG IL36RN MAP3K7 MAP2K6 GSDMD CHUK IL36G PSMA5 IL1F10 HLA-DRB5 PSMA6 IL4 HLA-DRB4 TOLLIP PSMA3 FLNA TSLP PSMA4 PTPN20 PSMA1 PTPN23 IL18BP PSMA2 AKT2 PSME3 IL31RA RIPK2 PSME4 EIF2AK2 IL13 PSME1 IL18 AKT1 PSME2 IRAK3 IL1A HLA-DRB3 EIF4E IL1B PSMD10 HLA-DRB1 IL1RAPL1 PSMB11 NOD1 PSMD12 NOD2 PSMD11 PSMD14 IL1RL2 ALOX5 PSMD13 JAK3 MAP3K3 PSMA7 PTPN18 RELA IL37 PTPN12 PTPN14 PSMB10 PSMA8 PTPN9 PTAFR PSMB6 PTPN7 PSMB7 STX4 PTPN4 PSMB4 STX3 PTPN5 PSMB5 IL18R1 PSMB2 CFL1 PTPN2 PSMB3 PSMB1 PSMF1 CSF3R NFKB1 PSMB8 IL6R PSMB9 CRLF1 NFKBIA EIF4G1 SEM1 PSMC5 CRLF2 TGFB1 PSMC6 PSMC3 SLA PSMC4 ITGB1 PSMC1 PSMC2 TNFRSF8 TNFRSF4 CISH NFKBIB TBK1 STAT6 IL6ST HSP90B1 TNFRSF17 SHC1 TNFRSF14 IP6K2 TNFRSF9 PIK3R1 CBL NRAS SNAP25 PIK3CA CIITA PLCG1 ITGAM SOS1 HRAS NANOG ITGB2 TNFSF13B ITGAX TRIM68 RAPGEF1 TRIM62 BIRC5 TNFRSF18 TNFRSF1B PIK3R2 SOS2 TNFRSF25 ADAM17 IL2RG CSK ABL2 TRIM46 TRIM48 TRIM45 IL2RA IL2RB TRIM35 IL32 TRIM38 TRIM31 TRIM34 TNFRSF6B ICAM1 CRKL IL27RA MT2A TRIM29 TNFSF11 PIK3R3 TRIM26 LGALS9 LCN2 TRIM22 TRIM17 CASP3 TRIM14 TRIM10 CTSG TIMP1 TNFSF18 TNFSF14 TNFSF15 TNFSF12 MMP1 TNFSF13 MMP2 MMP3 MMP9 BST2 GRB2 IL21 IL22 IL20 IL25 DUSP4 IL26 DUSP3 IL24 CD44 IL27 PPP2R5D LAMA5 VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B RHOU F13A1 IL11 IL15 IL19 IL16 RELB IL31 IL34 OSM INPPL1 STX1A RAG2 RAG1 IL4R PRTN3 VCAM1 SMARCA4 IL7R ADAR CD36 RPLP0 IL9R TEC CNTF UBE2D2 UBE2D1 HMOX1 HLA-DQA2 HLA-DQA1 LMNB1 EDARADD ZEB1 UBE2V1 HLA-DQB2 HLA-DQB1 IL10RB IL10RA CLCF1 CSF3 YWHAZ CSF2 CSF1 IL5RA LYN IGHG4 IGHG1 IL13RA2 PTK2B IL13RA1 MAP2K3 UBE2N TAB3 TAB2 EDAR TAB1 IFNAR1 MAPK11 VIM MCL1 BCL6 MAP3K14 BCL2L1 TRAF6 COL1A2 IGHE LBP CRK IL21R MAP2K1 TNIP2 MAP3K8 YES1 IFITM3 IFITM1 IFITM2 IL23R IFIT5 IFIT1 IFIT3 IFIT2 IL15RA HLA-H HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E IL23A STXBP2 TWIST1 ELOB ELOC LIF HCK NOS2 TNF MAPK14 CD40LG IL33 GRB10 IL1RL1 TP53 PTPN6 IL11RA LIFR IRAK1 HNRNPF PELI3 PELI2 ALOX15 PELI1 KPNB1 POU2F1 CD4 BRWD1 OASL BLNK SMAD3 SUMO1 OAS1 OAS2 OAS3 LTA IFNA5 LTB IFNA4 APP IFNA7 IFNA6 UBE2D3 IFNL2 IFNA2 MUC1 IFNL1 UBE2L6 HMGB1 IFNA8 GBP2 HERC5 GBP1 GATA3 IFNL3 GBP4 GBP3 NKIRAS1 NKIRAS2 CEBPD TRIM25 GBP6 GBP5 IFNA13 GBP7 IFNA14 IFNA16 DDX58 IFNA17 TRAF2 IL20RA IL20RB IRF3 TRAF3 IL22RA2 IRF7 IFNA10 UBA7 SOX2 AGER IL22RA1 S100A12 HLA-DPA1 IFNA21 IFNB1 ISG15 S100B VAMP2 NFKB2 RNASEL SAA1 CTF1 PIN1 PTGS2 CDKN1A H3C8 CDKN1B FLNB STAT2 HLA-DPB1 RORC PIM1 KPNA7 CCND1 KPNA4 KPNA5 IRF1 KPNA3 IRF2 TXLNA MAPKAPK3 UBE2E1 MAPKAPK2 H3C15 FSCN1 TNFRSF11B TNFRSF11A SH2B3 SOCS2 SOCS6 SOCS5 CXCL10 CAPZA1 HLA-DRA PPP2CA PPP2CB MYC PPM1B MAPK1 PTPRZ1 MAPK3 CCL5 CCL4 CCL3 CCL2 FCGR1A KPNA1 PTPN1 TALDO1 EIF4A2 EIF4A1 IFI35 IFI30 RSAD2 IFI27 CD86 CDC42 LCK CD80 FYN PAK2 VAV1 CCR1 CD27 SDC1 TNFRSF13B IRAK2 PTPRJ TNFRSF13C EDA2R IL10 IL6 ARIH1 CCR5 CCR2 TNFRSF12A OSMR NCAM1 IRS1 PIK3CD PIK3CB HGF FLT3LG GAB2 P4HB CD70 IL17F IL17C IL17A MID1 CCL3L3 HSPA8 IL2 ISG20 IL3 IL5 IL7 IL9 EDA IRF4 IRF8 IRF5 IRF6 IRF9 TCP1 SAMHD1 MX2 MX1 CNTFR JUNB FOXO3 ELK1 CREB1 BCL2 POMC CANX STAT3 TNFSF6 TNFSF4 TNFSF9 TNFSF8 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 HAVCR2 RAP1B VEGFA IFNGR1 NUP107 TRIM21 IFNGR2 NUP188 FN1 FCER2 CCL11 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.1 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.4 Glycogen synthesis GYG2 RPS27A GYG1 UGP2 UBA52 PGM2L1 EPM2A GBE1 GYS2 UBB GYS1 PGM2 PPP1R3C UBC NHLRC1 PGM1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 80%417957 P2Y receptors P2RY12 P2RY13 P2RY10 GPR17 P2RY14 P2RY11 LPAR6 LPAR4 P2RY6 P2RY4 P2RY2 P2RY1 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 80%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 80%5694530 Cargo concentration in the ER GOSR2 AREG GRIA1 TGFA CD59 LMAN2 F5 FOLR1 STX5 COL7A1 F8 SAR1B TMED2 MIA3 LMAN1L TMED10 CTSZ SEC22B SEC23A PREB LMAN1 LMAN2L SERPINA1 SEC24B CTSC SEC24A CNIH1 CNIH2 CNIH3 MCFD2 MIA2 SEC24D SEC24C SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 80%5654738 Signaling by FGFR2 TIAL1 PTBP1 FGFBP3 FGFBP1 RBFOX2 FGFBP2 GTF2F1 GTF2F2 HNRNPH1 ESRP2 ESRP1 BRAF PPP2CA HNRNPA1 PPP2CB TIA1 MKNK1 MAPK1 HNRNPM SPRY2 MAPK3 HNRNPF PPP2R1A FGF16 FGF7 FGF18 GAB1 UBA52 PIK3R1 CBL NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 POLR2A FRS3 POLR2B FGF1 POLR2C FGF2 POLR2D FGF3 FGF4 UBB POLR2E FGF6 POLR2F FGF9 POLR2G FGF20 POLR2H UBC POLR2I FGF23 POLR2J FGF22 POLR2K FGF10 RPS27A POLR2L NCBP1 NCBP2 PTPN11 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.5 Cell surface interactions at the vascular wall IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 TREM1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 CEACAM5 V1-3 IGKV3D-20 V5-6 INPP5D IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 CEACAM3 IGKV5-2 CEACAM1 IGKV1-5 CEACAM6 IGLC6 CEACAM8 YES1 ITGA3 SIRPA JCHAIN PECAM1 GP6 SLC16A8 SLC16A3 PTPN6 SELL F11R ITGA6 JAM2 JAM3 SLC7A11 SLC7A10 SLC7A5 SLC7A6 SLC7A9 SLC7A7 SLC7A8 ANGPT4 ANGPT2 ANGPT1 DOK2 GRB14 TEK SLC3A2 MIF TNFRSF10B TNFRSF10A ATP1B3 TNFRSF10D ATP1B2 ATP1B1 PPIA PTPN11 TSPAN7 PICK1 CXADR OLR1 SLC16A1 SPN PPIL2 TGFB1 ITGB1 JAML LCK FYN SHC1 PIK3R1 NRAS PIK3CA PLCG1 ITGAM L1CAM SOS1 HRAS SDC4 ITGB2 SDC2 ITGAL SDC3 ITGAX GPC1 SDC1 BSG ITGA4 PIK3R2 CAV1 CD47 APOB PIK3CB MAG GRB7 CD58 CD74 MMP1 ITGAV IGHM ITGA5 CD44 CD99 PROS1 VPREB3 VPREB1 FCER1G PSG1 PSG3 PSG2 PSG9 THBD FCAMR PSG8 PF4V1 PSG5 CD177 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 CD48 SELPLG EPCAM F2 IGLL1 CD84 SIRPG PSG11 SELE SELP PROCR ESAM MERTK PROC CD2 CD244 PF4 GAS6 IGHA1 IGHA2 ITGB3 IGHV3-23 FN1 IGLV IGLV2-8 IGKV1-16 GSD IV%REACTOME%R-HSA-3878781.2 GSD IV GYG2 GBE1 GYS2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 80%211935 Fatty acids CYP4A22 CYP4A11 CYP2A7 CYP2B6 CYP2A13 CYP2F1 CYP4F22 CYP4F12 CYP2J2 CYP2D6 CYP4F2 CYP4F3 CYP4B1 CYP4F8 CYP4F11 ACTIVATION OF RAC1%REACTOME%R-HSA-428540.4 Activation of RAC1 PAK1 PAK6 SOS2 PAK5 RAC1 PAK3 PAK2 SOS1 NCK2 ROBO1 PAK4 NCK1 SLIT2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 80%73933 Resolution of Abasic Sites (AP sites) PARP1 PCNA POLD3 NTHL1 MPG POLD4 POLD1 POLD2 PNKP POLE MBD4 RFC5 SMUG1 RFC3 NEIL2 RFC4 NEIL1 LIG1 PARG RFC1 POLB RFC2 OGG1 RPA2 APEX1 XRCC1 ADPRS LIG3 POLE4 RPA3 POLE2 PARP2 POLE3 TDG RPA1 FEN1 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 80%8943724 Regulation of PTEN gene transcription BMI1 RING1 EGR1 SNAI1 SNAI2 EZH2 MECOM HDAC2 PPARG RPTOR MLST8 SLC38A9 MBD3 SUZ12 GATAD2B JUN GATAD2A TP53 ATN1 RNF2 SALL4 HDAC7 MAF1 MTOR MAPK1 RRAGA MAPK3 RRAGC RHEB RRAGB CBX6 RRAGD CBX8 LAMTOR2 PHC2 LAMTOR1 PHC1 LAMTOR4 CHD4 LAMTOR3 CHD3 LAMTOR5 NR2E1 CBX4 EED CBX2 KDM1A HDAC5 MTA1 PHC3 MTA2 MTA3 REST HDAC3 HDAC1 RBBP4 RBBP7 RCOR1 ATF2 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.3 SUMOylation of ubiquitinylation proteins TRIM27 NUP62 NUP214 NDC1 PIAS4 SEC13 NUP210 NUP133 PIAS1 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 VHL MDM2 UBE2I NUP153 SUMO1 PML NUP107 NUP188 NUP35 NUP37 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 80%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADHA ECHS1 HADH ACADS INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 80%8963678 Intestinal lipid absorption GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 80%163359 Glucagon signaling in metabolic regulation ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CYSLTR2 GNG3 GNG2 GCG GNG5 GNG4 PRKAR2B GNG7 GNG8 PRKACG PRKACB ADCY9 PRKAR1B GNG10 PRKAR1A PRKAR2A GNG12 PRKACA GNG11 GNG13 GNB2 GNAS GNB1 GNB4 GNB3 ADCY4 SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.5 SARS-CoV-1 Infection CHMP4A CHMP6 ZCRB1 CHMP7 GSK3A PIK3R4 CTSL TMPRSS2 ACE2 MAP1LC3B VHL DDX5 UBE2I SUMO1 UVRAG ST6GALNAC2 PRKCSH UBA52 GANAB VCP ST3GAL4 MGAT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 MOGS UBB PARP10 PARP6 PARP4 PARP16 PARP9 UBC PARP14 PARP8 CANX RPS27A PIK3C3 GALNT1 ST6GALNAC3 ST6GALNAC4 BECN1 GSK3B RB1 PALS1 CHMP2B CHMP4C CAV1 CHMP2A CHMP4B CHMP3 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9767675.1 SARS-CoV-1-host interactions PALS1 CAV1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 80%198693 AKT phosphorylates targets in the nucleus AKT2 FOXO6 FOXO4 FOXO3 FOXO1 AKT1 CREB1 NR4A1 AKT3 RPS6KB2 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 80%2161541 Abacavir metabolism GUK1 ADH1A ADAL PCK1 NT5C2 ADAPTIVE IMMUNE SYSTEM%REACTOME%R-HSA-1280218.5 Adaptive Immune System HERC2 RAF1 SEC13 TAP2 TAP1 CLEC4G CD160 FCGR1BP PTPN22 TREM1 CLEC2B CLEC2D B2M CD101 cd21 INPP5D SIGLEC12 SIGLEC11 SIGLEC10 LILRA6 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 GLYCAM1 LILRB1 LILRB2 LILRB3 LILRB4 LILRB5 PDIA3 CD300A KLRF1 CD300E CD300C AHCYL1 KLRB1 TRIB3 KLRC1 MAPKAP1 RAP1GAP2 HSPA5 KLRD1 ULBP1 ULBP3 RICTOR NEDD4 KLRG1 THEM4 MYD88 PRR5 PTEN STUB1 TRPC1 ARF1 PPIA YWHAB AKT2 RIPK2 MLST8 AKT1 MTOR FKBP1A CALR ITGB1 NCF1 NCF2 SNAP23 NCF4 CYBB CYBA RAB7A VAMP3 PIK3R2 RACGAP1 S100A9 S100A8 RAP1GAP UBA6 UBE2Z UBE2L3 UBE2Q2 UBE2H UBE2B UBE2E3 PTPRC UBE2G1 UBE2A UBE2G2 ITGAV UBE2W UBE2R2 UBA1 PPP2R5D PPP2R1B FGB FGA FGG PPP3CB CD36 ENAH SH3GL2 TYROBP PPP2R5E PPP2R5B PPP2R5A PPP2R5C STIM1 ORAI2 ORAI1 ELOB ELOC ITPR1 ITPR2 ITPR3 PTPN6 CUL2 MIB2 KIF5C KIF5B KIF5A TREM2 KIFAP3 KIF20A KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C KIF18A KIF4B KIF4A KIF11 KIF15 CAPZB KIF23 KIF22 KIF2A SPTBN2 VASP SIAH2 KIF2C SIAH1 KIF2B SH3KBP1 CENPE KIF26A CAPZA1 CAPZA2 CLTC CLTA MYLIP SAR1B CDC20 DNM1 DNM2 DNM3 CTSA CANX LRR1 CCNF KEAP1 CBLB DCAF1 HERC4 HERC3 RNF115 RNF114 HERC1 TRIM21 FBXO7 RNF111 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 NEDD4L UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 FBXL7 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B GAN CALM1 RNF138 RNF130 HUWE1 KLHL2 WWP1 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 SOCS3 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F KLHL25 SMURF2 SMURF1 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO32 FBXO30 FBXO31 KLHL20 UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 BLMH UBE2M TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 TRIM69 UNKL TRIM63 DTX3L PJA2 PJA1 TRAF7 THOP1 TRIM50 RNF34 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 MKRN1 FBXL21P AKT3 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 GRAP2 FBXL16 FBXL13 PLCG2 FBXL14 FBXL12 TRIM39 ASB8 SYK ASB9 LNX1 LCP2 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 ACTR1A ASB3 ASB1 PPP2R1A LY96 CD14 S100A1 TIRAP BTRC PRKACA TLR1 TLR6 TLR4 TLR2 BLK SKP1 FBXW11 DYNLL1 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 DYNC1LI1 DYNC1LI2 UBB UBC RPS27A DYNC1H1 PTPN11 RBX1 DYNLL2 LRRC41 IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 IKBKG CXADR MAP3K7 CHUK PRKCB PSMA5 HLA-DRB5 PSMA6 HLA-DRB4 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 TREML1 PSME2 TREML4 TREML2 CARD11 HLA-DRB3 PSMD10 HLA-DRB1 PSMB11 LGMN PSMD12 SIGLEC9 PSMD11 PSMD14 PSMD13 BCL10 HCST PSMA7 RELA RAPGEF3 MALT1 RAPGEF4 PSMB10 PSMA8 PSMB6 PSMB7 STX4 PSMB4 PSMB5 KIR3DL1 PSMB2 KIR3DL2 PSMB3 TRAV8-4 PSMB1 SIGLEC1 PSMF1 SIGLEC8 NFKB1 PSMB8 SIGLEC7 PSMB9 SIGLEC6 NFKBIA SIGLEC5 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB JAML CD274 TNFRSF14 PIK3R1 OSBPL1A NRAS PIK3CA PLCG1 SOS1 ITGB5 HRAS ITGB2 ITGAL NCK1 ITGB7 CDH1 PIANP ITGA4 PIK3C3 EVL BECN1 CSK RBBP6 RILP PDCD1 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 BTK CTSV PIK3R4 CTSS PIK3R3 CTSL CTSK CD226 CTSD CTSB SH3RF1 CD207 CD200 IGHM PPP3CA ACTR1B IGHD WAS DYNC1I1 ACTR10 DAPP1 TRAV19 VCAM1 CRTAM TAPBP UBE2D2 IGHV3-23 UBE2D1 AP1S2 IGLV AP1S1 AP1S3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 ATG14 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 HLA-DQA2 HLA-DQA1 V3-2 IGHV3-33 NFATC3 V2-15 NFATC2 IGKV1D-39 NFATC1 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 HLA-DQB2 V1-11 HLA-DQB1 IGKV2D-30 V1-16 TRBV12-3 V1-13 TRBV7-9 IGHV4-59 IGHV1-69 RASGRP2 RASGRP1 IGLV2-11 YWHAZ IGLV1-40 IGLV1-47 ZAP70 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N VHL TAB2 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV CD300LB BTLA IGKV2-29 CD300LD IGKV2-28 IGLC3 IGLC1 CD300LF IGLC2 CD300LG AP1M2 V1-9 V5-4 AP1M1 V1-7 V5-1 V1-5 PDPK1 V1-3 MAP3K14 IGKV3D-20 V5-6 LAT TRAF6 IGLV3-19 AP1G1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG MAP3K8 PRKACB YES1 NECTIN2 IFITM1 KIF3A ICOSLG HLA-H HLA-B AP1B1 HLA-C HLA-A HLA-F HLA-G HLA-E TRAV29DV5 CD79B CD79A SH2D1A SH2D1B RAET1E ITCH SEC61G SEC61B PDCD1LG2 LAIR2 LAIR1 CD40LG CAPZA3 SIPA1 PVR CUL3 CD4 KBTBD7 SELL C3 BLNK COLEC12 UBE2D3 UBE2L6 HMGB1 HERC5 TRIM4 TRBC1 KLRK1 UBA7 FYB1 CTLA4 HLA-DPA1 UBE2K HLA-DMA HLA-DMB ANAPC10 HLA-DPB1 ANAPC11 FZR1 CDC23 CDC26 CDC27 HLA-DOA HLA-DOB LAG3 SKP2 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 HLA-DRA FCGR3A PPP2CA PPP2CB SEC22B SEC23A FCGR1A SEC24B SEC24A ERAP2 ERAP1 SEC24D FCGR2B SEC24C IFI30 CD86 CDC42 CD1D CD1C PAK1 CD1B LCK CD1A CD80 CD28 FYN RAC1 SLAMF7 PAK3 SLAMF6 PAK2 PAG1 VAV1 SEC31A PRKN PILRB PILRA CD22 CD3G PTPRJ CD3E CD3D BTNL9 CTSO BTNL8 CTSH BTN2A2 BTN3A1 CD209 CTSF BTN2A1 BTN1A1 CTSE BTN3A3 BTNL2 CD33 BTN3A2 CTSC XDH PPL NCR1 NCR2 NCR3 PIK3CD PIK3CB CD19 MICA TRAT1 MICB NPDC1 CD74 PIK3AP1 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 CD81 TRAC FBXW2 CD96 OSCAR CD8A KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 RASGRP3 CD99 FBXL3 FBXL5 SEC61A2 SEC61A1 DCTN6 DCTN5 DCTN1 DCTN4 PPP3R1 KIR2DS1 KIR2DS2 CD8B AP2S1 AP2A1 ITK AP2B1 AP2A2 MRC2 AP2M1 MRC1 RAP1B RAP1A CD200R1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 80%4090294 SUMOylation of intracellular receptors HDAC4 SUMO3 SUMO2 VDR PIAS4 PIAS3 NR3C2 PPARG ESR1 PIAS1 NR4A2 RARA PPARA THRB PGR NR5A1 UBE2I NR2C1 RXRA SUMO1 NR1H2 AR RORA NR3C1 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 80%5690338 Defective ABCC6 causes PXE ABCC6 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.3 p53-Dependent G1 DNA Damage Response PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME4 PSME1 CCNE1 PSME2 PSMD10 CDK2 PSMB11 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PHF20 PSMB9 CHEK2 ZNF385A SEM1 COP1 CDKN2A PSMC5 PCBP4 PSMC6 PSMC3 MDM2 PSMC4 MDM4 PSMC1 ATM PSMC2 CCNA2 CCNA1 UBA52 UBB UBC RPS27A CDKN1A CDKN1B SIGNALING BY EGFR%REACTOME%R-HSA-177929.2 Signaling by EGFR CDC42 AREG EPS15 SH3GL2 ADAM12 SHC1 EGF SH3GL3 GAB1 PIK3R1 PAG1 UBA52 CBL SRC TGFA EGFR NRAS PIK3CA SH3KBP1 PLCG1 LRIG1 EPGN SOS1 HRAS STAM PXN SH3GL1 BTC HBEGF UBB EREG PTPRK SPRY1 UBC RPS27A PTPN12 SPRY2 STAM2 ADAM10 AAMP HGS ADAM17 CSK PTPN11 ARHGEF7 EPN1 PTPN3 EPS15L1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 80%74752 Signaling by Insulin receptor INSR ATP6V1B2 ATP6V0D1 IRS1 ATP6V0C TRIB3 ATP6V0D2 FLT3 PIK3CB ATP6V1B1 FLT3LG PIK3R4 GAB2 TLR9 KLB AKT2 GRB10 MAPK1 IRS2 FGF19 MAPK3 FGFR4 THEM4 FGF16 FGF7 FGF18 PDE3B PDPK1 SHC1 GAB1 PIK3R1 NRAS PIK3CA SOS1 HRAS FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 PIK3C3 PIK3R2 ATP6V1H ATP6V1A TCIRG1 INS ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 PTPN11 ATP6V1F ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.5 Transcription from mitochondrial promoters MTERF1 TFAM TFB2M POLRMT PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME%R-HSA-71406.1 Pyruvate metabolism and Citric Acid (TCA) cycle CS ACO2 IDH2 SLC16A8 SLC16A3 GLO1 PDHB LDHC LDHB LDHA PDPR MPC1 MPC2 SLC16A1 PDK4 PDK3 DLAT PDK2 PPARD PDK1 PDHX PDHA2 PDHA1 PDP1 PDP2 LDHAL6A IDH3G LDHAL6B ME1 OGDH DLST DLD RXRA GSTZ1 VDAC1 NNT IDH3B ME3 BSG ME2 IDH3A SDHC SDHD SDHA SDHB SUCLG2 SUCLG1 L2HGDH FH D2HGDH FAHD1 MDH2 ADHFE1 SUCLA2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.7 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 TYROBP IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 TRBV12-3 TRBV7-9 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 CLEC4G IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 CD160 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 TREM1 IGKV3-20 IGHV4-34 IGHV1-2 CLEC2B IGHV1-46 IGHV4-39 IGHV CD300LB IGKV2-29 CD300LD IGKV2-28 CLEC2D B2M IGLC3 CD300LF IGLC1 CD300LG IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 cd21 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 SIGLEC12 IGHV3-48 SIGLEC11 IGLV3-25 SIGLEC10 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 LILRA6 NECTIN2 LILRA1 IFITM1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 GLYCAM1 LILRB1 LILRB2 LILRB3 LILRB4 HLA-H LILRB5 HLA-B HLA-C HLA-A CD300A HLA-F KLRF1 HLA-G HLA-E CD300E CD300C KLRB1 TRAV29DV5 SH2D1A SH2D1B KLRC1 RAET1E KLRD1 ULBP1 ULBP3 LAIR2 LAIR1 CD40LG KLRG1 PVR SELL C3 TREM2 COLEC12 TRBC1 KLRK1 CXADR TREML1 TREML4 TREML2 SIGLEC9 FCGR3A HCST KIR3DL1 KIR3DL2 TRAV8-4 SIGLEC1 FCGR1A SIGLEC8 SIGLEC7 SIGLEC6 SIGLEC5 ITGB1 FCGR2B JAML CD1D CD1C CD1B CD1A SLAMF7 SLAMF6 PILRB PILRA ITGB2 ITGAL ITGB7 CD22 CDH1 CD3G PIANP ITGA4 CD3E CD3D CD33 NCR1 NCR2 NCR3 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 CD19 MICA MICB NPDC1 CD226 CD81 TRAC CD200 CD96 OSCAR CD8A KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD99 TRAV19 VCAM1 CRTAM KIR2DS1 KIR2DS2 CD8B IGHV3-23 IGLV IGLV2-8 CD200R1 IGKV1-16 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 80%163680 AMPK inhibits chREBP transcriptional activation activity ADIPOR1 ADIPOR2 STK11 ADIPOQ PRKAA2 PRKAB2 MLXIPL PRKAG2 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.3 mTORC1-mediated signalling MTOR FKBP1A RRAGA RRAGC RPS6KB1 RHEB RRAGB AKT1S1 RRAGD LAMTOR2 YWHAB LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RPTOR EIF4G1 EEF2K MLST8 EIF4EBP1 SLC38A9 EIF4E EIF4B RPS6 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%189451 Heme biosynthesis ALB ALAS2 FECH COX15 UROS ABCG2 CPOX PPOX UROD ALAD HMBS COX10 ALAS1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.3 MAPK6 MAPK4 signaling PSMD8 PSMD9 CCND3 CDC42EP5 PSMD6 PSMD7 CDC42EP3 PSMD4 CDC42EP2 PSMD5 PSMD2 PSMD3 PSMD1 MOV10 PSMA5 KALRN PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 JUN MAPKAPK5 PSMD11 PSMD14 PSMD13 PSMA7 DNAJB1 XPO1 MYC PSMB10 PSMA8 PSMB6 FOXO1 PSMB7 AGO3 PSMB4 PSMB5 AGO4 PSMB2 AGO1 PSMB3 AGO2 PSMB1 PSMF1 PRKACA PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TNRC6C TNRC6A TNRC6B CDC42 PAK1 RAC1 PAK3 PAK2 UBA52 RAG2 HSPB1 RAG1 FOXO3 UBB IGF2BP1 UBC PRKACG PRKACB RPS27A NCOA3 CDK1 CDC14B ETV4 CDC14A MAPK6 MAPK4 SEPTIN7 DNA REPLICATION%REACTOME DATABASE ID RELEASE 80%69306 DNA Replication ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SKP2 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 PSMA4 H3C15 PSMA1 CCNE2 PSMA2 PSME3 PSME4 UBE2S PSME1 CCNE1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 KPNA1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 RPA1 PSMC4 PSMC1 PSMC2 FEN1 H3-3B CDC7 CCNA2 CCNA1 MCM10 DBF4 DNA2 PRIM2 PRIM1 RPA4 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 POLA1 POLA2 PCNA POLD3 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 POLE4 RPA3 POLE2 POLE3 KPNB1 SKP1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L UBA52 H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 CUL1 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB UBC H2AZ1 H2BC9 RPS27A H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 KPNA6 H2AC20 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 RBX1 H3C8 MCM3 UBE2D1 ANAPC15 MCM4 MCM5 ANAPC16 MCM6 ANAPC10 MCM2 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.2 Interleukin-37 signaling PTPN18 IL37 PTPN12 PTPN14 PTPN6 PTPN9 STAT3 PTPN7 PTPN4 PTPN5 SIGIRR IL18R1 PTPN13 PTPN2 PTPN20 PTPN23 SMAD3 IL18BP PTPN11 TBK1 CASP1 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 80%176033 Interactions of Vpr with host cellular proteins PSIP1 NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 SLC25A5 NUP85 TPR SLC25A4 NUP88 NUP43 SLC25A6 RAE1 RANBP2 KPNA1 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 BANF1 HMGA1 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.1 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 80%8941333 RUNX2 regulates genes involved in differentiation of myeloid cells CBFB LGALS3 RUNX1 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.5 Signaling by TGFB family members AMHR2 ZFYVE16 PARD3 GDF2 SMAD9 CGN PPP1R15A SMAD5 USP15 LTBP4 BMPR1B NEDD4L BMPR1A NEDD8 LTBP2 ACVRL1 LTBP3 BMPR2 LTBP1 NOG ITGB8 PARP1 GREM2 CCNT2 PMEPA1 CCNT1 ITGB6 TGFB2 TGFB3 UCHL5 SMAD7 TFDP1 BAMBI TFDP2 ITGA8 STRAP ARHGEF18 MYC MAPK1 FKBP1A PPM1A MAPK3 PPP1CC INHBB INHBA MEN1 CDK9 TGFB1 TGFBR1 TGFBR2 SKIL ITGB1 SKI ACVR1B ACVR1C NCOR2 NCOR1 HDAC1 E2F5 ACVR2B ACVR2A CBL CDKN2B ITGB5 SMURF2 SMURF1 RHOA UBE2M ATP1B4 PARD6A MTMR4 BMP10 TRIM33 SNW1 USP9X DRAP1 SMAD1 XPO1 PPP1CA SMAD6 BMP2 ITGAV PPP1CB FST F11R SMAD2 CDK8 SMAD3 FURIN SP1 CCNC SERPINE1 CER1 STUB1 AMH RBL1 UBE2D3 E2F4 FOXH1 TGIF1 TGIF2 UBA52 CCNK SMAD4 JUNB CHRDL1 UBB WWTR1 UBC RPS27A PRKCZ FSTL1 FSTL3 ITGB3 UBE2D1 RNF111 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.2 PI3K AKT Signaling in Cancer IRS1 PIK3CD FLT3 PIK3CB GSK3A AREG MAPKAP1 PDGFRB BAD CASP9 PDGFRA HGF AKT3 FLT3LG GAB2 PIK3R3 CHUK MET PDGFB SRC TGFA KLB CD19 NRG1 TRAT1 ESR1 ESR2 EPGN AKT2 STRN MLST8 PIK3AP1 AKT1 RICTOR TSC2 MTOR IRS2 RAC2 FOXO6 FGF19 FOXO4 FOXO1 FGFR4 RHOG FGF16 FGF7 AKT1S1 NR4A1 FGF18 PRR5 PTEN MDM2 KIT RPS6KB2 CD86 PDPK1 LCK CD80 CD28 FYN RAC1 EGF GAB1 VAV1 PIK3R1 EGFR PIK3CA FRS2 BTC FOXO3 NRG3 FGF1 NRG4 FGF2 NRG2 CREB1 FGF3 HBEGF FGF4 EREG FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 PIK3R2 ERBB2 GSK3B PTPN11 CDKN1A CDKN1B SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 80%425561 Sodium Calcium exchangers SLC8A1 SLC8A2 SLC8B1 SLC24A5 SLC8A3 SRI SLC24A2 SLC24A1 SLC24A4 CALM1 SLC24A3 UREA CYCLE%REACTOME%R-HSA-70635.1 Urea cycle CPS1 ARG1 ASL NAGS NMRAL1 ASS1 OTC SLC25A15 ARG2 SLC25A2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.3 E2F mediated regulation of DNA replication PPP2CA PPP2CB POLA1 POLA2 E2F1 PPP2R1A PRIM2 TFDP1 CDK1 PRIM1 PPP2R1B TFDP2 ORC5 MCM8 ORC4 RB1 CCNB1 ORC6 ORC1 PPP2R3B ORC3 ORC2 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 80%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 80%8984722 Interleukin-35 Signalling IL6ST IL12RB2 CANX JAK1 STAT3 IL27RA EBI3 STAT1 TYK2 STAT4 IL12A JAK2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 80%2562578 TRIF-mediated programmed cell death TLR4 TICAM1 CASP8 LY96 RIPK1 CD14 TICAM2 FADD RIPK3 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 80%194315 Signaling by Rho GTPases SEC13 NUP133 SRC DLG4 AAAS CALM1 NUP160 NUP85 NUP43 RANBP2 DDX4 ROCK1 TNFAIP1 RND3 MUC13 FLOT2 NUP37 WDR6 CKB FAM83B DSP ANKRD26 DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F PLD1 PTPN13 PLD2 CKAP4 KTN1 NISCH CCDC88A VANGL2 UBXN11 DLG5 CPD KCTD13 DSG1 PKP4 RBMX PICALM MTR SRRM1 DDX39B VAV3 YWHAE CCP110 PPP1CB PPP2R1A YWHAG HSP90AA1 PPP1R12A CYFIP2 ITSN2 ANKLE2 DYNLL1 WIPF1 CKAP5 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MYLK MAPRE1 PREX2 GJA1 WDR91 EPSTI1 ANKFY1 CEP97 PAFAH1B1 FNBP1 DYNC1I2 STARD8 PRKCD MRTFA FRS2 FRS3 AR DYNC1LI1 DYNC1LI2 MYL6 DAAM1 WDR81 MYL9 NGEF MTMR1 SHMT2 CDCA8 IQGAP1 IQGAP2 PRKCZ CLASP1 IQGAP3 SKA1 SKA2 DYNC1H1 NDE1 MYO6 SFN PLK1 HMOX2 STARD13 JUP FAM135A HNRNPC CDC42SE2 ARHGAP9 ARHGAP8 ARPC1B ARPC1A OSBPL11 LRRC1 ARHGAP4 NUF2 NUDC RRAS2 GMIP DYNLL2 CIT INCENP PRKCA CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 PKN3 GPS1 FGD1 FGD2 FGD3 FGD4 PRKCB FGD5 YWHAB CHN2 CHN1 FLNA STX5 FARP2 FARP1 KIDINS220 WWP2 DEF6 WDR11 LETM1 TMEM59 CENPF TAOK1 SHKBP1 PKN2 GOPC FILIP1 PKN1 UHRF1BP1L FAM13B PLXND1 FAM13A MSI2 PPP1CC STK10 SLK CFL1 POTEE MEN1 GOLGA8R LAMTOR1 TPM4 TPM3 RALGAPA1 CDC25C FAM91A1 TEX2 ARMCX3 CLIP1 OBSCN ITGB1 NCKAP1 PHIP CYFIP1 MAD1L1 TRIO NCF1 LIN7B TFRC RHOBTB1 NCF2 RHOBTB2 STIP1 SNAP23 NCF4 DDRGK1 ARHGAP1 DVL1 STK38 BRK1 DVL2 ARHGAP39 ARHGAP5 PLXNA1 ARHGAP6 DVL3 SRGAP3 ARHGAP35 SRGAP1 DOCK10 ARPC4 SYDE1 PREX1 ARPC5 NDC80 ARHGAP42 COPS4 BAIAP2L1 NSFL1C OPHN1 ARPC2 STBD1 ARPC3 ARHGDIB COPS2 PIK3R1 RAC3 EMD PLXNB1 NF2 LBR MAP3K11 GIT1 ARHGAP11A PIK3CA TMPO SWAP70 ZNF512B CDC37 ARHGAP11B ARAP2 RASGRF2 SOS1 CYBB TAGAP ARAP3 EFHD2 CYBA NCK2 OCRL VRK2 SPDL1 LEMD3 NCK1 ACTR3 VAV2 BCR PLEKHG3 ACTR2 TIAM1 DEPDC1B PLEKHG4 RAPGEF1 PLEKHG1 CDC42EP1 CDH1 PLEKHG2 PLEKHG6 DSG2 ARFGAP3 RAB7A RANGAP1 EPHA2 VAMP3 NIPSNAP2 ARFGAP2 GARRE1 BIRC5 AMIGO2 PIK3C3 NOXO1 EVL PIK3R2 PPP1R12B ARHGAP17 SOS2 SLC1A5 ROCK2 ARHGAP15 LMAN1 SRF ABR NSL1 PARD6B ARHGAP21 PARD6A PGRMC2 ARL13B RACGAP1 SH3BP1 SLITRK3 NHS CSK ABL2 RBBP6 SLITRK5 WHAMM NCKAP1L WASF3 WASF1 RNF20 SRGAP2 PPP1R14A WASF2 NDUFA5 YKT6 PCDH7 KLK2 CDC42BPB PAK4 CDC42BPA IL32 GIT2 JAG1 PRC1 CPNE8 CAV1 MCAM GOLGA3 MCF2 BAIAP2L2 ACTN1 ARHGAP26 BAIAP2 TIAM2 ZW10 MPP7 VANGL1 SPATA13 BTK ARHGAP32 PFN1 DIAPH3 TAOK3 CFTR ABI2 ROPN1 ABI1 PFN2 NOXA1 GRB7 NOX3 TMEM87A PIK3R4 ESYT1 NOX1 PIK3R3 FERMT2 TWF1 KLK3 KALRN S100A9 MYL12B S100A8 DSN1 SCFD1 SCAI SPTBN1 RCC2 STAM ZWINT PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 WASL USP9X SH3RF1 AKAP12 AKAP13 XPO1 HINT2 SH3PXD2A RAC2 SPTAN1 NDEL1 NCOA2 CCDC115 RHOG RHOH RHOF RHOC RHOD RHOB PPP2R5D ARHGEF9 CTTN RHOJ ARHGEF3 PPP2R1B ARHGEF4 RHOU ARHGEF1 TAX1BP3 ARHGEF2 RHOV ARHGEF7 RHOQ DBN1 ARHGEF5 ARHGEF6 C1QBP MIS12 WAS SAMM50 PLEKHG4B H2AX EMC3 CTNNA1 H2AB1 H2AC19 PAK6 DYNC1I1 PAK5 H2AC14 BCAP31 H2BC12L CAVIN1 MTX1 MYO9B H2BC21 MYO9A DLC1 H2BU1 TRIP10 H2AC8 B9D2 H2AC6 H2AC7 KNL1 SPC24 SPC25 H2BC17 ERCC6L H2BC12 STEAP3 H2BC13 RTKN H2BC14 H2AJ PRAG1 ZWILCH H2BC15 ARHGDIG H2BC11 ACTG1 ITGB3BP CENPA SYDE2 CENPC ARHGAP44 ARHGAP40 BASP1 H2AZ1 KNTC1 H2BC9 ARHGEF40 CENPT RALBP1 H2AZ2 KCTD3 CENPU ARHGAP45 SGO1 H4C9 ALDH3A2 H2BC8 SGO2 ELMO2 STAM2 H2BC5 ARHGEF26 H2BC3 ARHGEF25 ARHGEF28 H2BC1 ARHGAP19 ARHGAP18 CENPH PMF1 CENPI TOR1AIP1 H2AC20 ARHGAP12 CENPK NCKIPSD CENPL ARHGAP22 CENPM ARHGAP20 CENPN RHPN1 CENPO MYH14 CENPP MYH11 CENPQ RHPN2 CENPS ECT2 MYH10 CPSF7 ACBD5 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 DIAPH2 ARHGAP31 DNMBP ARHGAP30 SOWAHC ARHGEF10L RND2 RND1 LMNB1 YWHAQ MCF2L DBT FLOT1 YWHAH ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 ARAP1 YWHAZ SENP1 ZAP70 ARHGAP10 ALS2 GFOD1 PEAK1 NDUFS3 CCDC187 MOSPD2 ADD3 FAM169A UACA AURKB GNA13 TRA2B PTK2B STOM BUB1 CLASP2 RPS27 SPEN KDM4C LIMK2 LIMK1 HSPE1 SLC4A7 FMNL3 MAPK11 FMNL1 FMNL2 ACTC1 VIM H3-3B PDPK1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C PDE5A MAPK14 CUL3 RASAL2 KDM1A DOCK11 KIF5B KIF5A HSP90AB1 KLC1 KLC4 KLC3 KLC2 ABL1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 DOCK7 CAPZB PIN1 H3C8 CDKN1B KIF2A KIF2C KIF2B DOCK2 DOCK1 H3C15 CENPE PPP2CA PPP2CB MAPK1 CTNNB1 MAPK3 HGS CDC42 CLTC PAK1 LCK RAC1 PAK3 PAK2 VAV1 VCP ARHGDIA RHOA BUB1B CDC20 BUB3 MAD2L1 MYH9 ACTB CCT6A VAPB TUBA1B CCT2 CCT7 ERBIN NUP107 ATP6AP1 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 80%190861 Gap junction assembly GJD2 GJB2 GJD4 GJB1 GJD3 GJC1 GJC2 GJA10 GJA1 GJB4 GJB3 GJB6 GJB5 GJB7 GJA3 GJA5 GJA4 GJA9 GJA8 RHOJ GTPASE CYCLE%REACTOME%R-HSA-9013409.3 RHOJ GTPase cycle MPP7 VANGL1 ARHGAP32 DIAPH3 WWP2 WASL LAMTOR1 STOM RHOJ TRIO ARHGEF7 SLC4A7 TFRC FMNL3 SNAP23 ARHGAP1 WAS ARHGAP5 ARHGAP35 CDC42 PAK1 SYDE1 WIPF2 PREX1 SCRIB OPHN1 FNBP1L PAK3 PAK2 PIK3R1 GJA1 GIT1 TMPO FNBP1 STEAP3 OCRL DEPDC1B CDC42EP1 RAB7A NIPSNAP2 VAMP3 PIK3R2 IQGAP3 SLC1A5 DOCK8 ARHGAP21 ARL13B JUP PAK4 CDC42BPB CDC42BPA GIT2 CPNE8 CAV1 ARHGAP26 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 80%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RAD50 RAD51 RAD51B RAD51C RAD1 DNA2 RFC5 RFC3 HUS1 RFC4 BLM RFC2 RPA2 MRE11 RHNO1 WRN RPA3 ATRIP RAD17 ATR SEM1 BRCA2 RAD9B RAD51AP1 RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.5 Signaling by FGFR in disease GAB2 GTF2F1 GTF2F2 FGFR2 FGFR4 FGF16 FGF7 FGF18 BAG4 ZMYM2 CUX1 FGFR1OP2 MYO18A TRIM24 LRRFIP1 CPSF6 STAT1 ERLIN2 GAB1 FGFR1 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 POLR2A POLR2B FGF1 POLR2C FGF2 POLR2D FGF3 BCR FGF4 POLR2E FGF6 POLR2F FGF9 POLR2G FGF20 POLR2H POLR2I FGF23 POLR2J FGF22 POLR2K FGF10 POLR2L STAT3 NCBP1 NCBP2 CEP43 STAT5A STAT5B FGFR3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 80%3134975 Regulation of innate immune responses to cytosolic DNA RPS27A TRIM32 TREX1 TRIM56 UBA52 ZBP1 NLRP4 DTX4 TRIM21 TBK1 UBB IRF3 STING1 DDX41 UBC DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 80%3359485 Defective CD320 causes MMATC TCN2 CD320 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 80%193639 p75NTR signals via NF-kB IKBKB RELA NGFR PRKCI RPS27A NGF IRAK1 TRAF6 SQSTM1 UBA52 MYD88 NFKB1 NFKBIA RIPK2 UBB UBC CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 80%3247509 Chromatin modifying enzymes KDM5A KDM5B PHF2 KDM5C KDM5D KDM3B PHF8 UTY KDM6B KDM2A KDM4D KDM2B H2AW ARID5B HDAC10 JMJD6 H2AC17 RIOX2 H2AC12 H2AC1 H2BC18 HDAC8 H2AC21 KAT8 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 KAT14 TADA2A ZZZ3 SGF29 ING4 ING3 PRMT7 PAX3 SUPT3H TAF6L RPS2 BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 KDM4C ENY2 TAF5L MBIP DMAP1 DR1 COPRS MRGBP YEATS2 TADA1 VPS72 MSL2 MSL3 RUVBL2 MSL1 KANSL1 KANSL2 KANSL3 KMT2E SUV39H2 SETD2 PRDM9 SETD3 SETD6 DOT1L KMT2B SETD7 DPY30 NSD3 NSD1 NSD2 PRDM16 KMT5B SMYD3 ATF7IP SETDB1 KMT5C SETD1B SETDB2 SETD1A ASH1L AEBP2 ATF2 ASH2L EP400 CREBBP EZH2 MECOM KAT2B KAT2A EP300 MBD3 SUZ12 GATAD2B GATAD2A KDM3A KDM1B BRWD1 CHD4 CHD3 PRMT5 EED WDR77 KAT5 KDM1A MTA1 MTA2 MTA3 REST WDR5 ACTL6A SUV39H1 DNMT3A ARID4B SAP130 CLOCK MCRS1 SMARCD1 PHF21A SMARCD2 SMARCB1 SAP30 ARID2 SMARCD3 SMARCE1 SMARCC1 PBRM1 SMARCC2 OGT EHMT1 ACTL6B RBBP5 ARID1A SMARCA2 PADI2 ARID1B SAP30L SAP18 SUDS3 MEAF6 RCOR1 ARID4A NFKB2 ING5 BRMS1 EHMT2 HMG20B H3C8 BRD1 JAK2 CCND1 HDAC2 H3C15 KMT5A CDK4 KAT6A RELA SMYD2 BRPF1 BRPF3 NFKB1 PHF20 KDM7A KMT2A NCOR2 HDAC3 NCOR1 TBL1XR1 TAF9 HDAC1 KDM4A ATXN7 GPS2 TBL1X TAF12 TAF10 TRRAP TADA2B KDM6A TADA3 YEATS4 KMT2D KMT2C ACTB PRMT6 EPC1 NCOA2 USP22 HCFC1 PRMT1 KDM4B H2AX H2AB1 H2AC19 H2AC14 H2BC21 RUVBL1 H2BU1 H2AC8 CARM1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RBBP4 RBBP7 H2AZ1 H2BC9 SMARCA4 H2AZ2 PRMT3 H4C9 H2BC8 H2BC5 NCOA1 H2BC3 H2BC1 H2AC20 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 80%446219 Synthesis of substrates in N-glycan biosythesis GMDS ST8SIA6 ST3GAL6 FCSK FPGT NANS ST6GAL2 FUOM GFUS ST8SIA1 ST8SIA3 ST6GALNAC5 ST6GALNAC6 GNE GNPNAT1 RENBP SLC35A1 SLC35C1 NEU2 NEU3 GMPPB GMPPA NEU1 DOLPP1 MVD CTSA PMM1 GLB1 DPM1 DPM2 NUDT14 DPM3 UAP1 ST6GALNAC2 AMDHD2 GFPT2 PGM3 NAGK ALG5 NUS1 DHDDS ST3GAL4 ST3GAL1 GFPT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA4 ST8SIA2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC1 CMAS NPL NANP SRD5A3 MPI NEU4 SLC17A5 PMM2 ST8SIA5 DOLK ST3GAL5 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 80%8964616 G beta:gamma signalling through CDC42 GNGT2 CDC42 PAK1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNG3 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 ARHGEF6 GNGT1 GNG8 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME%R-HSA-5654228.2 Phospholipase C-mediated cascade; FGFR4 FGF19 FGFR4 FGF16 FGF18 KLB PLCG1 FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 80%168255 Influenza Infection RPS11 RPS10 RPL39 RPS13 RPS12 NUP62 KPNA7 NUP214 RPS9 KPNA4 RPL21 NDC1 KPNA5 RPS7 RPS8 SEC13 NUP210 RPS5 KPNA3 RPL23 HSPA1A IPO5 RPL22 NUP133 GRSF1 PARP1 RPL13A RPSA DNAJC3 RPS3A RPL9P9 CPSF4 NUP93 RPL37A RPL24 EIF2AK2 RPL27 NUP50 RPL26 NUP54 RPL29 RPL28 NUP205 POM121 RPS4Y2 RPL10 AAAS RPL12 RPS6 NUP160 RPL11 RPL36A RPS27L RPS4Y1 POM121C RPS15A NUP42 RPL14 NUP85 RPS3 RPL13 RPS2 TPR RPL15 NUP88 RPL18 SLC25A6 NUP43 RPL17 RAE1 RPL19 RPL39L CALR RANBP2 RPL41 RPL35A KPNA1 RPL23A NUP155 RPL3L RPS26 PABPN1 TGFB1 RPS25 RPS28 RPS27 RPS29 NUP153 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 NUP35 RPS23 NUP37 CLTC CLTA POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 XPO1 KPNA2 RAN KPNB1 HSP90AA1 UBA52 RPL4 CANX RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 ISG15 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL NUP107 RPS18 NUP188 RPL36 RPL35 RPLP2 RPL38 RPL37 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.7 Gene expression (Transcription) BMI1 KRAS KDM5B NUP62 NUP214 NDC1 SEC13 NUP210 RING1 NUP133 PARP1 HDAC11 NUP93 NUP50 HDAC9 NUP54 NUP205 POM121 BLM AAAS NUP160 RNF2 HDAC7 WRN CSF1R POM121C NUP42 NUP85 TDG TPR NUP88 NUP43 RAE1 RANBP2 GTF2B CBX8 PHC2 GTF2E1 PHC1 GTF2E2 RNMT NUP155 RNGTT CBX4 CDKN2A CBX2 PCGF2 RPA1 BRD2 NUP153 PHC3 PML NUP35 NUP37 EIF4A3 CASC3 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 ATF2 SRSF6 SLU7 SRSF7 PIP4K2A SRSF9 PIP4K2B FYTTD1 PIP4K2C LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 MAPKAP1 U2AF1L4 U2AF2 DHX38 SRSF11 VENTX MOV10 CHTOP ALYREF UPF3B MAGOHB EZH2 PPARG RNPS1 PCNA SLC2A3 FKBP5 RICTOR MBD3 RFC5 MSX2 RFC3 SUZ12 OPRM1 GATAD2B MAF RFC4 GATAD2A DLX5 DLX6 RFC2 TWIST2 HIVEP3 RPA2 PPARGC1B ESRRA SMAD1 RPA3 SMAD6 BMP2 FOXO6 ITGBL1 FOXO4 SP7 TSNAX AGO3 UCMA FOXO1 ZNF521 PRKRA AGO4 NKX3-2 AGO1 RBM14 CBX6 AGO2 HAND2 NR4A1 DICER1 PPM1D BGLAP TSN TARBP2 PRR5 PTEN CHD4 CHD3 NR2E1 EED BRIP1 HDAC5 KAT5 EXO1 MTA1 RBBP8 MTA2 NBN MTA3 BARD1 RMI2 TNRC6C RMI1 TRPC3 STUB1 TOP3A TNRC6A RAD51D RAD50 TNRC6B RAD51 DNMT3A PRDX2 PRDX1 STAT1 SMARCD1 SMARCD2 SMARCB1 ARID2 YAF2 SMARCE1 CCNK SMARCC1 SMAD4 PBRM1 ZFHX3 TP53RK MT-CO1 SMARCC2 EHMT1 ACTL6B NOC2L AUTS2 GLS PCGF5 TP53AIP1 ARID1A SMARCA2 HUS1 COX7A2L ARID1B SCO1 RYBP SCO2 DDIT4 MT-CO2 MT-CO3 RHNO1 L3MBTL1 MEAF6 NUAK1 TP53BP2 ATRIP GTF2H1 PRELID3A GTF2H2 BANP PRELID1 GTF2H3 SURF1 GTF2H4 GTF2H5 TPX2 DDB2 SOD2 RAD17 CDK12 ATR COX7B ERCC3 ELL IFNG SETD9 ERCC2 CHM COX7C BBC3 TAF7L ING5 ING2 PIP4P1 EHMT2 AIFM2 RRN3 ELOA COX8A CBX3 ERCC6 BRD1 SGK1 MEF2C COX5B LMO1 COX5A LMO2 PMS2 TAF9B MTERF1 BRD7 TIGAR MLH1 HIPK1 COX6C POU4F2 LRPPRC HIPK2 PRKAA1 TTC5 PRKAA2 CCNG1 TCEA1 MAP2K6 RAD1 CCNT2 YWHAB PRKAG1 CCNT1 PRKAG2 TACO1 PRKAG3 PRDM1 COX6A1 RPTOR STK11 SESN3 SESN2 AKT2 KMT5A BNIP3L MLST8 SUPT16H AKT1 IGFBP3 SLC38A9 COX6B1 MSH2 FANCD2 PRKAB2 KAT6A MAPKAPK5 COX19 COX16 COX18 TSC2 NDRG1 TSC1 PRKAB1 SMYD2 MTOR PMAIP1 COX11 PPM1A COX14 BCL2L14 RRAGA ZNF420 PTPN4 RRAGC FANCI BRPF1 RHEB BRPF3 RRAGB TNFRSF10C ELOA2 RRAGD SPI1 LAMTOR2 FANCC LAMTOR1 CDK9 LAMTOR4 TP53I3 LAMTOR3 RUNX1 JMY CYCS TAL1 LAMTOR5 TAF4B RARA RAD9B TGFB1 RAD9A CEBPB KMT2A COX20 DYRK2 CBFB PPP1R13B COX4I1 RXRA TRIAP1 DEK PPP1R13L TOPBP1 GPX2 RABGGTB RABGGTA RRM2B TMEM219 GLS2 TAF9 TAF1L TP53INP1 RFFL TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 TAF11 SSRP1 TAF7 TAF6 LBR TAF5 PPARGC1A TAF4 TAF3 TAF2 TAF1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 MED23 MED25 MED24 MED20 PPARA RSPO3 JAG1 CAV1 YY1 KMT2D KMT2C MED30 MED31 USP7 USP9X HDAC6 ITGA5 PGR PPP2R1B CLDN5 SERPINB13 SP1 SOCS4 AXIN1 CCNC GTF2A1 GTF2A2 GP1BA SSB PF4 PCK1 NFIX NFIA NFIB WWTR1 NFIC SMARCA4 HNF4G NR5A1 YAP1 PERP GCK SMAD7 TCF3 LDB1 MYBL2 H3-3B CCNA2 CCNA1 NOTCH2 NOTCH3 NOTCH4 KMT2E DNA2 KMT2B POLR2A DPY30 POLR2B MED1 POLR2C POLR2D MED8 POLR2E POLR2F MED4 POLR2G POLR2H POLR2I MED6 POLR2J SETD1B POLR2K MED7 POLR2L SETD1A AEBP2 RARG PPP2R5C ASH2L ELOB ELOC TEAD1 TCF12 RARB MAPK14 IRAK1 RAN DLL1 PLXNA4 CDK8 SMAD2 SMAD3 WDR61 MYBBP1A MYB WDR5 ZFPM1 GATA4 GATA3 GATA2 GATA1 SMARCD3 ABL1 NFE2 RBBP5 CBX5 FIP1L1 CDK5 KLF4 SOX2 SOX9 H3C8 HEY1 HEY2 RXRB HDAC2 H3C15 TCF7L2 TCF7L1 MYC TCF7 LEF1 CTNNB1 RUNX3 PHF20 CHEK2 ZNF385A PCBP4 MDM2 MDM4 ATM KIT BAZ1B CDK5R1 NR1H2 THBS1 OPRK1 IL6 DGCR8 GAMT PLK2 RBFOX1 GPRIN1 PVALB HTT MOBP GAD1 GAD2 AFF4 CDC73 CTR9 MLLT1 RTF1 MLLT3 SUPT6H IWS1 LEO1 EAF1 EAF2 PAF1 OCLN TJP1 NOP2 CGA HSPD1 PIWIL2 TDRKH PIWIL1 PIWIL4 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 NFYA NFYB DDIT3 NFYC ELAC2 CRH CLP1 SLBP CSTF3 CSTF2 CSTF1 SYMPK POMC PCF11 WDR33 SRRT INS SF3B1 NUDT21 RNF111 PAPOLA NEDD4L CAMK2B GRIA2 CAMK2D SRC CAMK2A CPSF4 GRIN2B CPSF1 CPSF3 CPSF2 GRIN2A CALM1 CAMK2G BAX BID WWP1 CSTF2T CSNK2A1 PABPN1 CSNK2A2 DDX4 CSNK2B KCTD6 PLD6 BCDIN3D UHRF1 PHF19 DROSHA PHF1 JARID2 TET2 TET1 TET3 MTF2 IPO8 DNMT3L XPO5 SOCS3 G6PC1 SMURF2 SMURF1 TFAM TFB2M POLRMT FBXO32 TRIM63 RNF34 AKT3 DDX21 GPAM JUN FOS YWHAE PPP2R1A PRKACA YWHAG BLK SKP1 ELF1 HSP90AA1 ELF2 PAX5 PIDD1 APAF1 CRADD SERPINE1 CASP6 RORA CASP1 NR3C1 CASP2 NLRC4 TP63 TP73 SREBF1 UBA52 NR1D1 CUL1 AURKA AR CCNB1 UBB MYL9 UBC RPS27A USP2 BCL2L11 SFN CENPJ BDNF TNFRSF10B TNFRSF10A CDK1 TNFRSF10D ZNF17 FASLG ZNF287 ZNF18 PTPN11 ZNF19 ZNF285 ZNF282 RBX1 ZNF10 ZNF12 ZNF14 ZNF705EP ZNF28 PSMD8 ZNF274 PSMD9 ZNF273 FAS PSMD6 ZNF20 PSMD7 ZNF23 PSMD4 ZNF25 PSMD5 ZNF26 PSMD2 ZNF268 PSMD3 ZNF267 PSMD1 ZNF266 ZNF264 ZNF263 NR2F1 TXNIP ZNF34 PRKCB NR0B2 PSMA5 NR2F6 PSMA6 ZNF30 PSMA3 ZNF257 PSMA4 ZNF256 PSMA1 ZNF254 PSMA2 PSME3 ZNF496 PSME4 ZNF253 PSME1 ZNF493 PSME2 ZNF250 ZNF492 ZNF490 PSMD10 ZNF43 PSMB11 ZNF45 PSMD12 ZNF41 PSMD11 ZNF248 PSMD14 ZNF486 PSMD13 ZNF485 ZNF484 PSMA7 ZNF483 RELA ZNF480 ZNF479 PSMB10 ZNF235 PSMA8 ZNF234 PSMB6 ZNF233 PSMB7 PPARD PSMB4 FOXP3 ZNF230 PSMB5 ZNF471 PSMB2 ZNF470 PSMB3 PSMB1 ZNF227 MEN1 PSMF1 ZNF468 ZNF226 NFKB1 ZNF225 PSMB8 ZNF224 PSMB9 ZNF223 CDC25C ZNF222 SEM1 ZNF221 PSMC5 ZNF461 PSMC6 CRCP ZNF460 PSMC3 ZNF77 PSMC4 ZNF79 PSMC1 SKI PSMC2 ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 ZNF213 NCOR2 ZNF697 HDAC3 ZNF454 NCOR1 ZNF696 TBL1XR1 ZNF212 HDAC1 ZNF211 SIN3A ZNF692 CAMK4 ZNF691 GPS2 RORB TBL1X ZNF208 ZNF205 ZNF689 ZNF688 ZNF446 ZNF445 PITX2 EGFR ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 ZNF682 ZNF440 ZNF681 ZNF680 ITGAL ZFP69B ZNF439 ZNF679 ZNF678 ZNF436 ZNF677 ZNF676 ZNF433 ZNF675 ZNF432 ZNF431 ZNF430 ITGA4 ZNF671 BIRC5 ZNF670 TNFRSF18 ZNF840P ZKSCAN7 ZNF429 ZKSCAN8 ZNF669 ZKSCAN3 ZNF668 ZNF426 ZNF667 ZNF425 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 ZKSCAN1 ZNF662 ZNF660 ZNF419 IL2RA ZNF418 ZNF417 ZNF658 ZNF416 ZNF415 ZNF655 NPPA ZNF649 TBX5 ZNF641 NKX2-5 ZNF875 ZNF627 ZNF626 ZNF625 SST ZNF624 ZNF621 ZNF620 ZNF860 LGALS3 MGA ZNF619 CTSV ZNF616 ZNF615 ZNF614 ZNF613 ZNF611 ZNF610 TRIM33 CTSL IHH UXT ZNF729 TRIM28 CTSK ZNF727 PRMT6 ZNF726 NR4A3 ZNF724 EPC1 ZNF721 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 ZNF324B HDAC4 L3MBTL2 ZNF709 ZNF708 SATB2 ZNF707 ZNF706 ZNF704 MMP13 ZNF703 ZNF701 ZNF700 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 SPP1 INTS14 INTS10 HNF4A ZFP14 ZNF585B RXRG ZNF585A ZFP28 PRDM7 ICE1 ICE2 IGFBP1 SSU72 ZNF99 ZNF92 H2AX VDR H2AB1 NABP2 H2AC19 NABP1 TGIF1 ZNF75CP H2AC14 H2BC12L CAVIN1 TGIF2 ZNF804B H2BC21 TAF8 ZNF175 ZSCAN32 ZNF169 H2BU1 ZNF705G H2AC8 ZNF705D H2AC6 ZNF160 H2AC7 ZNF705A H2BC17 ZSCAN25 H2BC12 ZNF157 H2BC13 ZNF398 STEAP3 H2BC14 ZNF155 ZNF154 H2AJ H2BC15 ZNF394 H2BC11 NR2C2AP ZNF141 ZNF383 ZNF140 ZNF382 RBBP4 NR1D2 RBBP7 H2AZ1 ELL2 H2BC9 ELL3 ZNF37A H2AZ2 ZNF702P ZNF138 NPM1 ZNF136 ZNF135 H4C9 H2BC8 ZNF133 ZNF124 ZIK1 H2BC5 ZNF599 H2BC3 ZNF114 SMARCA5 ZNF597 H2BC1 CAT ZNF596 ZNF112 ZNF595 ZNF350 RETN H2AC20 ZNF589 ZNF347 ZNF473 ZNF587 LSM10 ZNF586 LSM11 ZIM2 BTG1 ZNF343 MSTN ZNF101 SIRT3 ZIM3 FOXG1 ZNF584 ZNF100 NPY ABCA6 ZNF583 CPSF7 UBE2D1 PINK1 ZNF582 CCNG2 PCGF6 AGRP ZNF33B ZNF33A ZNF337 ZNF577 ZNF334 ZNF333 ZNF573 ZNF331 ZNF571 ZNF570 ZFP30 ZNF569 ZNF568 NFATC2 ZNF567 ANG ZNF324 ZNF566 HDAC10 GPI ZNF565 ZFP37 YWHAQ ZNF564 ZNF563 ZNF320 HDAC8 PRKCQ ZNF562 YWHAH ZNF561 ZNF560 NRBP1 ZNF317 ZNF559 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 YWHAZ ZNF554 MRE11 ZNF311 ZNF552 CSF2 ZNF793 ZNF551 ZNF792 ZNF550 ZNF791 ZNF790 KRBA1 KRBOX4 KRBOX5 ZNF767P ZNF549 AURKB ZNF548 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 ZNF782 ZNF540 ZNF658B ESRRB MAPK11 ESRRG ZFP69 ZNF778 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 MAX ZNF772 E2F5 ZNF530 PDPK1 POLR3GL ZNF771 BCL6 ZNF770 COL1A1 CDC7 ZC3H8 ZNF529 ZNF528 ZNF764 ZNF761 ZNF75D ZFP90 E2F6 ZNF75A CR1 ZNF519 CDKN2B ZNF517 RRM2 ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 ZNF740 GTF3C1 RPRD2 GTF3C2 POLR3A ZNF738 GTF3C3 POLR3B ZNF737 GTF3C4 POLR3C ZNF736 GTF3C5 POLR3D ZNF735 GTF3C6 POLR3E ZNF732 ZNF730 SNAPC5 POLR3F ZNF607 SNAPC1 POLR3G ZNF606 SNAPC2 YES1 POLR3H ZNF605 SNAPC3 POLR3K ZNF600 SNAPC4 ZNF143 ZNF839 BRF2 RPAP2 BRF1 ZNF726P1 GTF3A ZNF2 BDP1 ZNF3 ZNF354A ZNF354C ZNF354B ATP1B4 RPRD1B RPRD1A POU2F2 NR4A2 THRB THRA GSK3B ZNF197 ZNF195 GLI3 NR2C2 GLI2 NR2C1 ZNF189 ZNF286A ZNF184 ZNF180 TWIST1 ITCH CREBBP NOTCH1 MAML2 MAML1 RBPJ KAT2B KAT2A SNW1 EP300 GTF2F1 HES1 MAML3 GTF2F2 MAMLD1 TP53 LIFR POU2F1 PHAX SNRPD3 TFAP2A TFAP2B PRMT5 WWOX TFAP2C UBE2I TFAP2D SNRPG SUMO1 TFAP2E SNRPE KCTD1 KCTD15 SNRPF SNRPB ACTL6A UBE2D3 CCNH SUV39H1 ARID4B TTF1 RRP8 SIN3B SAP130 UBTF DNMT3B SAP30BP CASP10 TBP SIRT1 SAP30 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H DNMT1 BAZ2A TAF1D TAF1B TAF1C SAP30L TAF1A SAP18 SUDS3 MBD2 CDK7 MNAT1 TEAD4 CCN2 TEAD2 CTLA4 TEAD3 PIN1 RB1 CDKN1A ANAPC15 CDKN1B ANAPC16 ANAPC10 ANAPC11 RORC FZR1 CCND3 CDC23 CCND2 CCND1 CDC26 CDC27 E2F1 SKP2 DAXX ANAPC7 UBE2C UBE2E1 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2CA PPP2CB MAPK1 MAPK3 PTPN1 G6PD ATXN3 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CHEK1 APOE CITED1 CITED2 CITED4 YEATS4 MET TGFA ACTB ESR1 ESR2 IL2 IL3 CGB8 ATAD2 BTG2 TNKS1BP1 CNOT6L PRMT1 RBL2 RBL1 PLAGL1 E2F4 E2F7 E2F8 PLK3 GADD45A ARID3A CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT1 CNOT11 CARM1 CNOT2 CNOT3 CNOT8 CNOT9 FOXO3 JUNB CREB1 ERBB2 CDK13 ITGA2B VEGFA MDC1 NUP107 NUP188 BRCA1 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 80%166662 Lectin pathway of complement activation FCN3 COLEC10 MBL2 MASP1 FCN1 COLEC11 FCN2 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 80%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A2 MAN1A1 MAN1C1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 80%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) RPA3 MLH1 MSH6 PCNA POLD3 POLD4 POLD1 RPA1 POLD2 EXO1 MSH2 LIG1 RPA2 PMS2 MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 80%110056 MAPK3 (ERK1) activation CDK1 JAK1 MAPK3 PTPN11 TYK2 IL6 MAP2K1 IL6R JAK2 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.1 Netrin mediated repulsion signals NTN1 UNC5A UNC5B UNC5C UNC5D PTPN11 SRC DCC ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.3 ADP signalling through P2Y purinoceptor 12 P2RY12 GNGT2 GNG10 GNG12 GNG11 GNAI3 GNG13 GNAT3 GNAI1 GNB2 GNAI2 GNB1 GNB4 GNG3 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic NSF KIF6 COPZ1 ZW10 KIF27 STX18 NAPG KIF9 KIFC2 ARF5 KIF2A KIFC1 NBAS KIF2C KIF2B COPG2 COPG1 ARCN1 CENPE RINT1 KIF26A KIF26B COPB2 COPA TMED10 SEC22B COPB1 KIF28P COPE USE1 KIF5C KIF5B KIF5A ARFGAP1 KIF21A ARF3 KIF21B KIFAP3 RAB1A KIF16B RAB1B KIF20A KIF20B ARF4 KLC1 BNIP1 KLC4 KLC3 KLC2 KDELR1 KIF3B NAPA SURF4 KIF3C ARF1 TMED2 KIF18A KIF18B ARFGAP3 KIF4B KIF4A ARFGAP2 KDELR2 KDELR3 GBF1 KIF3A RACGAP1 KIF12 KIF11 KIF15 KIF19 KIF13B TMED3 KIF1C TMED7 KIF1B KIF1A TMED9 COPZ2 KIF25 KIF23 NAPB KIF22 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 80%174403 Glutathione synthesis and recycling OPLAH GGT1 GGT5 GGT3P GSS GGT7 GCLC GGT6 CHAC2 GGCT CHAC1 GCLM GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.3 GRB2 events in ERBB2 signaling ERBB2 EGF EGFR NRAS NRG1 SOS1 HRAS BTC NRG3 NRG4 NRG2 HBEGF EREG FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.2 Formation of editosomes by ADAR proteins ADARB1 ADAR REPRODUCTION%REACTOME DATABASE ID RELEASE 80%1474165 Reproduction MLH1 RAD51C LMNB1 CD9 SMC1A H3C15 CDK4 CDK2 BLM MRE11 HVCN1 RAD21 RPA1 ATM STAG1 STAG2 H3-3B TINF2 TERF1 TERF2 POT1 TERF2IP PRDM9 ADAM2 ACR IZUMO3 OVGP1 IZUMO2 IZUMO1 ZP1 ZP3 ZP2 SPAM1 ZP4 ADAM21 ADAM30 ACD H3-4 RPA2 CATSPER1 KCNU1 RPA3 CATSPER3 CATSPERB CATSPER2 SYCP2 CATSPER4 SYCP1 CATSPERD SYNE2 CATSPERG SYNE1 SUN2 SUN1 TEX12 HSPA2 SMC1B SYCE3 SYCE2 SYCE1 REC8 STAG3 SPO11 BRCA2 TEX15 SYCP3 MSH4 MSH5 FKBP6 UBE2I DMC1 PSMC3IP RBBP8 NBN MND1 MLH3 TOP3A RAD50 RAD51 H2AX H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 B4GALT1 ATR H2BC1 H2AC20 H3C8 BRCA1 SMC3 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 80%8863795 Downregulation of ERBB2 signaling RNF41 CUL5 AKT3 EGF UBA52 EGFR NRG1 CDC37 AKT2 BTC AKT1 NRG3 NRG4 NRG2 HBEGF UBB EREG UBC PTPN18 MATK RPS27A PTPN12 ERBB2 ERBIN HSP90AA1 USP8 STUB1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 80%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 80%167169 HIV Transcription Elongation CCNH ELOB ELOC TCEA1 SSRP1 CCNT1 POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 ELOA2 SUPT5H CDK9 ERCC3 ELL ERCC2 ELOA NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 80%5654727 Negative regulation of FGFR2 signaling UBA52 CBL FRS2 FGF1 FGF2 FGF3 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 BRAF PPP2CA FGF22 PPP2CB FGF10 MKNK1 RPS27A MAPK1 SPRY2 MAPK3 PPP2R1A FGF16 FGF7 FGF18 PTPN11 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 80%381753 Olfactory Signaling Pathway OR4D2 OR4D1 OR5F1 ANO2 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR3A2 OR4A15 OR4C3 OR14A2 OR3A1 OR4A16 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4C46 OR4B1 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR52A4P OR2D3 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR2B3 OR5H6 OR4F5 OR10K2 OR4F4 OR2B2 OR4F3 OR10K1 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP2 OR52J3 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2B11 OR2AP1 OR51F2 OR51F1 OR2G6 OR5M9 OR52H1 OR5M8 OR1E3 OR1E2 OR4K5 OR2G3 OR1E1 OR2G2 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR1D5 OR2T27 OR51E1 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 CNGA2 CNGA4 LDB1 ADCY3 GNAL LHX2 OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 EBF1 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR1I1 OR2K2 OR6S1 OR5M11 OR5M10 OR2I1P OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 OR2T1 OR13C8 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR1Q1 OR2S2 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR10A3 OR56A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR6C68 OR8B3 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 GNG13 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 GNB1 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5AL1 OR8H3 OR5D13 OR8H2 OR8H1 OR52M1 OR10V1 OR2AT4 OR4C12 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR7C2 OR9G4 OR7C1 OR9G1 OR2A14 OR5G3 OR4E2 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 80%9759774 Diseases of mitochondrial beta oxidation MMUT MMAA DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 80%5688031 Defective pro-SFTPB causes SMDP1 and RDS SFTPB MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-390648.2 Muscarinic acetylcholine receptors CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 80%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAPK9 MAPK8 IRAK2 MAPK10 IRAK1 TRAF6 IKBKG MAP3K7 UBE2N TAB3 TAB2 RIPK2 TAB1 UBE2V1 MAP2K4 MAP2K7 NOD1 NOD2 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.2 Cardiac conduction FXYD1 FXYD7 FXYD6 SCN9A HIPK1 HIPK2 CAMK2B CAMK2D CAMK2A SCN8A CACNA1C CALM1 CAMK2G KCNJ11 ABCC9 SCN5A KCNK10 SCN4A KCNK2 SCN4B KCNK4 SCN7A KCNH2 KCNQ1 SCN11A KCND1 KCND2 KCND3 SCN10A KCNJ2 KCNJ4 KCNJ12 ATP2A3 ATP2A2 ATP2A1 SLC8A1 KCNJ14 SLC8A2 RYR1 NOS1 RYR2 RYR3 SLN CLIC2 NPPC TRDN NPR1 ASPH NPR2 PLN AHCYL1 NPPA TNNI3 STIM1 DMPK TBX5 NKX2-5 FKBP1B CORIN ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI KAT2B ATP2B4 ATP2B3 ATP2B2 ATP2B1 KCNK6 KCNK7 KCNK9 SLC8A3 KCNK16 KCNK17 KCNK18 KCNK1 KCNK3 CACNB1 CACNB2 KCNK13 PRKACA TRPC1 SCN1B SCN1A GATA4 AKAP9 CACNG8 CACNA2D2 KCNK12 KCNK15 CACNG4 SCN3B SCN3A WWTR1 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 FGF14 SCN2A FGF13 SCN2B FGF12 FGF11 KCNK5 KCNIP1 KCNIP2 KCNIP3 KCNIP4 ATP1B3 ATP1B2 ATP1B1 CACNG6 ATP1A4 CACNG7 ATP1A3 ATP1A2 ATP1A1 RANGRF FXYD4 FXYD3 FXYD2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.2 Synthesis of PIPs at the Golgi membrane PIK3C2G PIK3C3 TPTE2 PIK3R4 TPTE INPP5E VAC14 PI4K2B ARF1 OCRL PIK3C2A FIG4 SACM1L PIKFYVE PI4KB ARF3 PI4K2A INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 80%177243 Interactions of Rev with host cellular proteins RANBP1 NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 XPO1 RANGAP1 POM121C NUP42 NUP85 NPM1 TPR RCC1 NUP88 NUP43 RAN RAE1 KPNB1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.1 Activated NTRK3 signals through PLCG1 PLCG1 NTRK3 NTF3 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 80%9705462 Inactivation of CSF3 (G-CSF) signaling UBE2D3 RNF7 ELOB ELOC STAT1 CUL5 UBA52 HCK SOCS3 SOCS1 UBB SYK CSF3 UBC RPS27A JAK1 STAT3 LYN TYK2 CSF3R STAT5A STAT5B UBE2D2 UBE2D1 JAK2 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.1 Noncanonical activation of NOTCH3 YBX1 PSEN1 APH1A PSENEN APH1B PSEN2 NOTCH3 NCSTN DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 80%9651496 Defects of Formation of Fibrin Clot (Clotting Cascade) GGCX VWF KLKB1 F10 GP1BB F12 F11 GP1BA F2 GP5 TPST2 GP9 TPST1 F8 F9 SERPING1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.2 RNA Polymerase III Abortive And Retractive Initiation POLR3GL TBP POLR1C POLR1D SSB GTF3C1 NFIX GTF3C2 POLR2E POLR3A NFIA GTF3C3 POLR2F POLR3B NFIB GTF3C4 POLR3C NFIC GTF3C5 POLR2H POLR3D GTF3C6 POLR3E SNAPC5 SNAPC1 POLR2K POLR3F SNAPC2 POLR2L POLR3G SNAPC3 POLR3H SNAPC4 POLR3K ZNF143 BRF2 BRF1 GTF3A BDP1 POU2F1 CRCP SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 80%9669934 Sunitinib-resistant KIT mutants KIT TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.5 Transport of small molecules ATP6V1B2 ATP6V0D1 ANO2 ATP6V0C RAF1 ATP6V0D2 ATP6V1B1 SLC35B3 SLC35B2 NEDD4L LCN9 SLC27A1 CAMK2B SLC35B4 SLC35D1 ATP8A1 SLC35D2 CAMK2D SLCO1B1 LCN15 SLCO2B1 CAMK2A LCN12 SLCO1B3 APOD SLC16A2 SLC35A2 SLC35A1 SLC35A3 SLC33A1 SLC35C1 SLCO1C1 ARL2BP SLCO4A1 SLCO2A1 SLCO1A2 CALM1 SLCO4C1 CAMK2G LCN1 SLC29A4 WWP1 SLC27A6 AVP SLC25A5 SLC28A2 SLC29A1 SLC28A1 SLC15A4 SLC25A4 SLC29A3 ATP8B4 SLC25A6 SLC29A2 SLC28A3 SLC27A4 SLC2A10 SLC5A7 SLC5A9 SLC45A3 SLC5A1 SLC5A3 SLC5A4 SLC10A6 SLC2A14 SLC2A11 SLC2A13 SLC2A12 MFSD4B SLC14A1 SLC11A1 SLC14A2 SLC2A6 SLC2A7 SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC47A2 SLC47A1 SLC5A11 SLC5A10 SLC13A5 SLC50A1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 ABCA12 ABCA10 TFR2 ABCB6 ABCB7 ABCB5 ABCB8 ABCB9 ABCA2 ABCA5 ABCA9 ABCA7 ABCA8 ABCC10 ABCC11 NIPA1 NIPA2 DMTN ABCB10 ATP8A2 ATP12A RYR1 ATP11C RYR2 IREB2 RYR3 SLN ATP8B3 ATP8B2 CLIC2 ATP8B1 TRDN CYBRD1 ASPH PIP PLN ACO1 ATP7B MB FKBP1B NGB ATP10D ATP10B ATP10A LRRC8C LRRC8D LRRC8A LRRC8B ATP9B ATP9A LRRC8E SLC9A2 NIPAL4 SLC9A3 NIPAL1 SLC9A4 NIPAL2 SLC9A5 NIPAL3 SLC5A2 SLC9A6 AZGP1 SLC9A7 ANKH SLC9A8 RAB11FIP2 SLC2A3 SLC9A9 ATP4B SLC9A1 ATP4A MYO5B SLC16A7 CUTC SLC16A8 MRS2 EMB SLC22A17 SLC16A3 SLC66A1 FTMT HFE MMGT1 ABCG4 STEAP2 GLRX3 ATP2C2 ATP2C1 AHCYL2 STOML2 ADD2 SLC4A2 MCUB ABCF1 SLC4A3 SPG7 ATP13A1 SLC4A4 MAIP1 ATP13A4 PHB2 SLC4A5 ATP13A5 SLC26A11 SLC6A19 PARL ATP13A2 SLC12A6 SLC6A18 AFG3L2 SMDT1 SLC12A7 SLC6A15 PMPCB SLC38A1 SLC22A2 YME1L1 SLC15A1 SLC22A1 PMPCA SLC15A2 SLC6A14 SLC5A8 SLC6A13 MICU3 SLC26A2 SLC6A12 MICU2 PRKACA SLC26A1 SLC6A11 TRPM1 MICU1 MCU SLC6A20 TRPM2 SLC1A1 SLC6A1 TRPM7 SLC1A2 SLC6A2 TRPM8 SLC1A3 SLC6A3 TRPM5 SLC1A4 SLC6A5 TRPM6 SLC1A6 SLC6A6 SKP1 TRPM3 SLC1A7 SLC5A5 SLC6A7 TRPM4 SLC6A9 SLC38A3 TRPC7 SLC18A1 SLC15A3 TRPC5 SLC18A2 SLC38A2 MCOLN3 SLC38A5 TRPC6 SLC38A4 TRPA1 SLC4A10 TRPC3 SLC16A10 TRPC4 SLC26A7 TRPC1 SLC26A9 TRPV2 SLC26A4 TRPV3 SLC26A3 TRPV1 SLC26A6 MCOLN1 MCOLN2 SLC7A11 SLC7A10 TRPC4AP SLC32A1 TRPV6 SLC7A5 TRPV4 SLC7A6 TRPV5 SLC7A9 SLC25A18 SLC7A7 SLC3A1 SLC7A8 ERLIN2 SLC25A10 SLC24A2 UBA52 SLC24A1 SLC5A6 SLC24A4 SLC24A3 SLC43A2 SLC20A2 SLC20A1 SLC43A1 PDZD11 SLC5A12 SLC3A2 SLC7A1 SLC7A3 CUL1 SLC25A26 SLC25A29 SLC17A6 SLC17A7 SLC17A8 UBB CA1 SLC17A1 PRKAR2B SLC36A4 SLC25A22 SLC12A2 UBC SLC12A3 SLC12A4 RPS27A SLC12A5 SLC12A1 CTNS SLC4A8 SLC4A9 SLC24A5 HMOX2 ABCC2 SGK1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 LETM1 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 RUNX1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TFRC ATP11B CLCN6 ATP11A FTL SLC36A1 SLC36A2 BSG SLC1A5 SLC17A5 A2M RNF5 RNF185 CFTR CYB5R2 CYB5R1 CYB5R4 CA2 CA4 LCN2 HBA2 CYB5RL RHAG SLC4A1 AQP1 SLC34A3 SLC34A2 SLC34A1 AQP12A AQP10 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 MIP AQP11 FURIN SLC22A4 RSC1A1 SLC22A6 SLC22A5 SLC22A12 SLC22A15 SLC22A16 SLC22A8 SLC22A11 TF STEAP3 ANO8 RAB11A SLC41A2 SLC41A1 SLC30A10 HEPH SLC39A6 CAND1 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 ABCA6 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC31A1 ABCC4 SLC30A5 SLC11A2 SLC39A10 ABCC5 SLC30A1 SLC39A14 BEST2 HMOX1 SLC9C1 BEST3 NEDD8 SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 SLC2A9 WNK1 WNK2 WNK3 UNC80 TSC22D3 AQP8 ANO9 ANO7 ANO4 ANO5 ANO3 ANO1 SGK3 SGK2 STOML3 ADD3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 CLCA3P STOM TPCN2 TPCN1 ABCC1 CLCN7 CLCN5 CLCN4 OSTM1 UNC79 SLC4A7 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A EIF2S2 EIF2S1 EIF2S3 PRKAR2A ATP2A3 FTH1 ATP2A2 ATP2A1 SLC8A1 SLC8A2 GNAS ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SRI ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 DERL1 DERL3 ERLIN1 ABCG8 ABCG5 SLC2A8 ABCA3 ABCB4 ABCD1 HBB ATP1B3 ATP1B2 ATP1B1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 SLC40A1 CP SLC22A7 AKAP1 ABCC3 ABCA4 SLC2A1 ATP7A SLC16A1 KCNJ11 ABCC9 SLC22A3 ABCB1 ABCG2 CLTC HDLBP PCSK9 CLTA VLDLR ZDHHC8 LIPA LDLRAP1 MYLIP CUBN AMN LSR NPC1 VCP SOAT1 SOAT2 NPC2 SEL1L CES3 DERL2 SAR1B ERLEC1 LDLR SLC8B1 OS9 ABCA1 VDAC3 NR1H2 VDAC2 APOC4 VDAC1 NR1H3 APOBR NCEH1 APOC1 SLC2A2 SLC2A4 CETP MTTP LCAT LPL PCSK6 PCSK5 LMF2 ANO6 LMF1 LIPC CREB3L3 LIPG APOF APOE APOB GPIHBP1 FGF21 MBTPS1 APOA2 APOC3 APOA1 APOA4 ABCD2 APOA5 APOC2 ALB ANGPTL8 ANGPTL3 P4HB ANGPTL4 LPA MBTPS2 ABCG1 PEX3 SLC46A1 ADD1 ARL2 GNG10 GNG12 PEX19 GNG11 GNG13 GNB2 GNB1 GNB4 RHCG SCNN1G RHBG GNB3 SLC22A18 SCNN1D SCNN1B SCNN1A GNB5 FBXL5 AVPR2 GNGT1 GNGT2 TUSC3 MAGT1 GNG3 GNG2 GNG5 ABCC6 GNG4 GNG7 GNG8 AP2S1 ATP6V1H AP2A1 ATP6V1A TCIRG1 AP2B1 PHB1 AP2A2 AP2M1 ATP6V0A2 ATP6V0A4 ATP6V1E1 CYGB ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 ATP6V1F ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.1 LXRs regulate gene expression linked to lipogenesis NRIP1 FASN RXRA NR1H2 SCD NR1H3 ANGPTL3 RXRB NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.1 Nucleotide salvage UPP2 GMPR2 UPP1 ADK AMPD1 TYMP GMPR AMPD2 AMPD3 UCKL1 DCK UCK2 APRT UCK1 ADAL PUDP DGUOK TK2 TK1 PNP HPRT1 ADA CDA CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.1 crenolanib-resistant FLT3 mutants FLT3 SUMOYLATION%REACTOME DATABASE ID RELEASE 80%2990846 SUMOylation BMI1 HERC2 INCENP SUMO3 SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 HIPK2 NUP210 IKBKG RING1 NUP133 DAXX PARP1 NSMCE3 NSMCE2 NSMCE1 HDAC2 SMC1A PIAS1 NUP93 RNF168 EID3 NSMCE4A NUP50 NUP54 SP100 NUP205 POM121 BLM XPC AAAS NUP160 SENP1 RNF2 HDAC7 RELA WRN POM121C NUP42 NUP85 RAD21 TDG TPR NUP88 NUP43 RAE1 RANBP2 CBX8 AURKB PHC2 PHC1 XRCC4 NUP155 NFKBIA CBX4 RARA VHL CDKN2A CBX2 MDM2 PCGF2 RPA1 NUP153 PHC3 RXRA PML RAD52 STAG1 STAG2 NUP35 NUP37 NCOR2 CASP8AP2 MBD1 TP53BP1 HDAC1 SIN3A TOP2A TOP1 UHRF2 PPARGC1A NR1H2 RANGAP1 PARK7 UBA2 DDX17 SAE1 BIRC5 ZNF131 NR4A2 PPARA THRB NR2C1 TRIM27 CREBBP TOP2B NR3C2 PPARG ESR1 PCNA TRIM28 EP300 SATB1 NOP58 SUZ12 TP53 SENP5 SENP2 CETN2 HDAC4 L3MBTL2 SATB2 MITF ZBED1 SAFB FOXL2 PIAS3 HIC1 NCOA2 SP3 TOPORS CHD3 PGR TFAP2B DDX5 TFAP2C UBE2I MTA1 SUMO1 RORA NR3C1 DNMT3A VDR DNMT3B NRIP1 IKBKE MRTFA DNMT1 CBX5 AURKA AR CTBP1 HNRNPK RWDD3 CDCA8 NPM1 H4C9 NCOA1 ZNF350 HNRNPC NFKB2 NR5A1 ING2 MDC1 NUP107 NUP188 SMC5 SMC6 BRCA1 SMC3 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 80%380612 Metabolism of serotonin MAOA ALDH2 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 80%1236974 ER-Phagosome pathway IKBKB PSMD8 PSMD9 PSMD6 BTK PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SEC61G IKBKG SEC61B CHUK PSMA5 PSMA6 S100A9 PSMA3 S100A8 PSMA4 PSMA1 PSMA2 PSME3 PSME4 TAP2 PSME1 PSME2 TAP1 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SEC22B PSMB10 PSMA8 PSMB6 PSMB7 STX4 PSMB4 PSMB5 PSMB2 LY96 PSMB3 PSMB1 CD14 CALR S100A1 PSMF1 MYD88 TIRAP TLR1 PSMB8 PSMB9 TLR6 SEM1 TLR4 PSMC5 TLR2 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SNAP23 B2M SEC61A2 SEC61A1 FGB FGA HMGB1 FGG UBA52 UBB UBC VAMP3 RPS27A CD36 TAPBP HLA-H HLA-B PDIA3 HLA-C HLA-A HLA-F HLA-G HLA-E FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 80%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 MASP1 FCN1 FCN2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 80%446353 Cell-extracellular matrix interactions VASP FBLIM1 FERMT2 TESK1 ILK PARVA PARVB FLNA FLNC RSU1 LIMS2 LIMS1 ITGB1 PXN ARHGEF6 ACTN1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.1 Toll Like Receptor TLR6:TLR2 Cascade RPS6KA2 IKBKB RPS6KA1 ATF1 SIGIRR IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 UBE2V1 RIPK2 IRAK3 NOD1 NOD2 PPP2CA RELA PPP2CB MAPK1 MAPK3 NFKB1 NFKBIA MAP2K3 UBE2N TAB3 TAB2 TAB1 NFKBIB MAPK11 TRAF6 SOCS1 MAP2K1 TNIP2 MAP3K8 IRAK2 ATF2 BTK S100A9 S100A8 MAP2K4 MAPK14 MAP2K7 JUN FOS MAPK9 MAPK8 MAPK10 IRAK1 PELI3 PELI2 PELI1 PPP2R1A LY96 CD14 S100A1 MYD88 DUSP4 BTRC DUSP3 TIRAP PPP2R5D TLR1 VRK3 DUSP6 TLR6 DUSP7 TLR4 MAPK7 PPP2R1B IRAK4 TLR2 SKP1 FBXW11 APP FGB FGA HMGB1 FGG UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB UBC RPS27A AGER S100A12 CD36 ECSIT MAP3K1 S100B NFKB2 SAA1 MEF2A MEF2C RPS6KA3 RPS6KA5 SIGNALING BY PDGF%REACTOME%R-HSA-186797.4 Signaling by PDGF COL9A1 COL9A3 CRKL COL9A2 PIK3CB PDGFRB PDGFRA GRB7 PDGFB SRC PTPN12 RASA1 PLG FURIN PLAT THBS4 THBS3 SPP1 PDGFD STAT6 BCAR1 STAT1 COL4A2 PIK3R1 COL4A1 COL6A2 NRAS PIK3CA COL4A4 CRK PLCG1 COL6A1 SOS1 HRAS COL4A3 NCK2 NCK1 COL6A3 COL4A5 COL6A6 RAPGEF1 COL6A5 THBS2 THBS1 STAT3 PIK3R2 STAT5A STAT5B PTPN11 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.1 Intra-Golgi and retrograde Golgi-to-ER traffic NSF KIF6 COPZ1 KIF27 KIF9 VAMP4 PAFAH1B3 KIFC2 PLIN3 ARF5 KIF2A KIFC1 NBAS TMF1 KIF2C KIF2B ARFRP1 STX6 STX5 RIC1 ARCN1 GOLIM4 RAB43 RAB41 CENPE RINT1 RAB30 KIF26A RAB36 CAPZA1 KIF26B CAPZA2 ARL1 VPS45 RAB6B PAFAH1B2 SEC22B BICD1 BICD2 RHOBTB3 BET1L ARFGAP1 RAB6A ARF3 RAB1A RAB1B VPS51 VPS53 PLA2G6 VPS52 VPS54 KDELR1 GCC2 SURF4 GCC1 GOLGA5 GOLGA1 ARFIP2 TMED2 COG8 COG7 COG6 SNAP29 COG5 COG4 ARFGAP3 RAB18 COG3 COG2 VAMP3 COG1 ARFGAP2 KDELR2 KDELR3 KIF3A PLA2G4A RAB39A RACGAP1 TMED3 YKT6 TMED7 TMED9 RAB33B NAPB AGPAT3 ZW10 STX16 STX18 NAPG STX10 RGP1 RAB3GAP2 TRIP11 COPG2 COPG1 RAB3GAP1 SYS1 CAPZA3 COPB2 COPA TMED10 MAN2A2 COPB1 ACTR1A ALPP KIF28P COPE USE1 RABEPK KIF5C MAN1A2 KIF5B MAN1A1 KIF5A NAA30 KIF21A KIF21B KIFAP3 KIF16B KIF20A KIF20B CUX1 DYNLL1 NAA35 NAA38 ARF4 GOSR2 GOSR1 DYNC1I1 DCTN6 CYTH3 DCTN5 CYTH2 KLC1 DCTN1 CYTH4 TGOLN2 BNIP1 ACTR10 DCTN4 MAN1C1 KLC4 CYTH1 KLC3 KLC2 MAN2A1 GALNT2 RAB9A KIF3B PAFAH1B1 NAPA DYNC1I2 RAB9B DCTN2 KIF3C DCTN3 USP6NL ARF1 SCOC DYNC1LI1 DYNC1LI2 GOLGA4 KIF18A KIF18B M6PR KIF4B KIF4A IGF2R GALNT1 DYNC1H1 VTI1A GBF1 KIF12 KIF11 KIF15 KIF19 CAPZB KIF13B KIF1C KIF1B KIF1A COPZ2 KIF25 KIF23 DYNLL2 KIF22 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.2 VxPx cargo-targeting to cilium ASAP1 RHO ARF4 RAB11FIP3 PKD2 PKD1 RAB3IP CNGA2 GBF1 CNGA4 RAB11A EXOC8 EXOC7 RAB8A EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 CNGB1 EXOC1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.1 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.3 Serotonin Neurotransmitter Release Cycle RAB3A UNC13B SYT1 SYN3 CPLX1 SNAP25 SYN2 STX1A SYN1 RIMS1 PPFIA1 VAMP2 PPFIA4 TSPOAP1 PPFIA3 PPFIA2 SLC18A2 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.1 APC truncation mutants have impaired AXIN binding PPP2CA PPP2CB AMER1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.3 Disassembly of the destruction complex and recruitment of AXIN to the membrane DVL2 DVL3 WNT8A WNT8B LRP5 CSNK1A1 LRP6 WNT3A CSNK1G2 WNT1 PPP2CA PPP2CB FRAT1 AMER1 FRAT2 CTNNB1 PPP2R1A FZD1 PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 FZD2 FZD5 PPP2R5B PPP2R5A CAV1 PPP2R5C DVL1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.2 Signal regulatory protein family interactions PTPN6 FYB1 SIRPA PTK2 PTPN11 SKAP2 TYROBP SIRPG CD47 PTK2B SIRPB1 MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 80%164516 Minus-strand DNA synthesis PPIA NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 80%164944 Nef and signal transduction LCK FYN ELMO1 RAC1 PAK2 HCK DOCK2 DEPURINATION%REACTOME%R-HSA-73927.2 Depurination H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 MPG H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 OGG1 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 80%6783589 Interleukin-6 family signaling IL6ST IL31 JAK1 IL11RA OSM LIFR STAT3 LIF STAT1 TYK2 IL6 CBL IL6R CRLF1 SOCS3 CNTFR IL31RA CTF1 IL11 PTPN11 CNTF OSMR CLCF1 JAK2 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.8 Metabolism of proteins BMI1 HERC2 SUMO3 SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 NUP210 RING1 NUP133 PARP1 NSMCE3 NSMCE2 NSMCE1 SMC1A PIAS1 NUP93 RNF168 EID3 NSMCE4A NUP50 NUP54 SP100 NUP205 POM121 BLM XPC AAAS NUP160 RNF2 HDAC7 WRN POM121C NUP42 NUP85 RAD21 TDG TPR NUP88 NUP43 RAE1 RANBP2 CBX8 PHC2 PHC1 XRCC4 NUP155 CBX4 CDKN2A CBX2 PCGF2 RPA1 NUP153 PHC3 PML RAD52 STAG1 STAG2 CAMKMT NUP35 NUP37 B2M HARS1 MUCL1 AARS1 RARS1 KARS1 MARS1 YARS1 DARS1 WARS1 AIMP1 GARS1 AIMP2 SARS1 EPRS1 NARS1 QARS1 PPA1 LARS1 IARS1 FARSA EEF1E1 CARS1 TARS1 FARSB VARS1 UBA2 SAE1 PDIA3 CSF2RB CSF2RA PCNA USP18 PARS2 EARS2 LARS2 PPA2 TARS2 AARS2 SSR1 HARS2 TRAM1 GFM2 BARD1 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF SRP72 SRP68 SRP19 GOLGA2 MTFMT DNMT3A YARS2 NARS2 RARS2 CARS2 VARS2 SRPRA SRPRB MARS2 DARS2 SARS2 MTRF1L VNN1 MTIF2 VNN2 MTIF3 IARS2 WARS2 FGF23 DDB2 CUL4A DDB1 CHM CUL4B ING2 TAF9B NSF HIPK2 EIF4EBP1 IGFBP3 EIF4E EIF4B RPS6 RRAGA EIF4G1 SFTA3 TGFB1 SFTPB TGFBR1 SFTPC TGFBR2 SFTPA2 SFTPA1 RABGGTB RABGGTA TAF10 RAB7A LMAN1 YKT6 ST6GALNAC1 CMAS NPL NANP NEU4 EDEM3 SLC17A5 EDEM1 AMFR ST8SIA5 RNF5 ST3GAL5 ST8SIA6 RNF103 ST3GAL6 RNF139 TRIM13 NANS ST6GAL2 UGGT2 ST8SIA1 RNF185 ST8SIA3 UGGT1 ST6GALNAC5 MARCHF6 ST6GALNAC6 GNE LTF SLC34A2 SLC34A1 UBA6 UBE2Z FUT3 UBE2L3 UBE2Q2 USP7 UBE2H USP5 UBE2B B4GALNT2 USP9X UBE2E3 SENP5 UBE2G1 SENP2 UBE2A UBE2G2 UCHL3 UBE2W UBE2R2 UBE2T OTULIN UBA1 PGR DDX5 APC SERPINC1 PROS1 AXIN1 KNG1 RCE1 ICMT FGA F10 SERPIND1 ARF4 USP17L2 FGG F2 F5 EXOC8 EXOC7 F7 F8 PROC F9 EXOC4 PROZ EXOC3 EXOC6 EXOC5 EXOC2 WDR48 EXOC1 DTL RAD18 RWDD3 RPL4 RPL5 RPL30 PRMT3 ETFB RPL3 METTL21A RPL32 KIN RPL31 RPL34 METTL22 RPLP1 EEF2KMT RPL10L GBF1 ETFBKMT RPLP0 VCPKMT RPL10A RAB11A EEF1AKMT2 RPL8 EEF1AKMT1 RPL6 RPL7 EEF1B2 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 SLC30A7 SLC30A6 RPL36 SLC30A8 RPL35 RPLP2 RPL38 RPL37 RPS11 SLC30A5 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 USP15 RPS7 NEDD8 RPS8 RPS5 RPL23 RPL22 LTBP1 RPL13A RPSA RPS3A RPL9P9 EEF1G EEF1A1 UCHL5 EEF1D SMAD7 EEF1A2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 EEF1A1P5 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A EEF2 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 PPP6C PPP6R3 H3-3B CCNA2 CCNA1 MANEA CHST10 CHST8 MGAT3 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 POFUT2 LARGE2 B3GALNT2 GALNTL5 GALNTL6 ANKRD28 B3GNTL1 EIF1AX GALNT9 EIF4H GALNT8 EIF2S2 POMGNT2 EIF2S1 B3GNT9 EIF3M B3GNT8 EIF2S3 B3GNT6 EIF3K B3GNT5 CHST4 EIF3L EIF3I GCNT1 EIF3J GCNT3 EIF3G GCNT4 EIF3H GCNT7 EIF3E GALNT7 EIF3F GALNT6 EIF3C GALNT5 EIF3D GALNT4 EIF3A A4GNT EIF3B POMK DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 MITF FOXL2 HIC1 SP3 DOLPP1 MVD SMAD2 SMAD3 WDR61 KIF5C KIF5B KIF5A GATA6 GATA4 GATA3 OGT CBX5 RAB5A CAPZB H3C8 NFE2L2 HDAC2 H3C15 CAPZA1 CAPZA2 TCF7L2 MYC CTNNB1 HGS COP1 MDM2 MDM4 UBXN1 BABAM1 PMM1 BABAM2 DDA1 UIMC1 PTRH2 CASP8AP2 ABRAXAS1 MBD1 SPSB3 BRCC3 CCDC8 NUDT14 TP53BP1 UAP1 ATXN7 AMDHD2 NAE1 PCSK9 GFPT2 PGM3 COMMD10 BAP1 TOP1 UHRF2 FEM1C FEM1A FEM1B NAGK ALG5 COMMD8 COMMD2 COMMD1 COMMD6 SAR1B COMMD7 COMMD4 COMMD5 VDAC3 NR1H2 STAMBPL1 VDAC2 ENGASE VDAC1 NGLY1 SPON2 MYSM1 SEMA5B ERCC8 SPON1 THSD7B DCAF8 B3GLCT DCAF5 THBS2 DCAF4 ADAMTS12 DCAF6 THBS1 USP17L4 THSD1 USP17L5 THSD4 USP17L8 ADAMTS10 DDX17 ADAMTSL1 WSB2 RHOA ADAMTS15 ALG10B CDC20 ADAMTS2 TADA2B ADAMTS14 ZNF131 ASGR1 ADAMTS3 ADAMTS13 ASGR2 ADAMTSL5 IL6 FN3KRP ADAMTSL4 WDR20 ADAMTS19 USP17L3 ADAMTSL3 USP17L1 ADAMTSL2 USP3 ADAMTS17 FKBP8 THSD7A STAMBP ADAMTS6 CUL9 ADAMTS7 WDTC1 SBSPON FN3K SSPOP TADA3 ADAMTS20 CCDC22 TULP4 STS DCAF16 CDC73 DCAF17 CTR9 DCAF10 DCAF11 RTF1 USP17L30 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 LEO1 DCUN1D1 DCUN1D2 ARSA PAF1 UMOD DPH1 DPH2 DPH3 DPH5 SUMF2 DPH6 SUMF1 DPH7 PUM2 TOP2B ANKRD9 GNPNAT1 RENBP USP17L21 USP17L20 USP17L22 USP17L15 USP17L18 USP17L17 USP17L19 SATB1 USP17L10 USP17L12 USP17L11 USP17L13 NEU2 ALG10 CLSPN DNAJC24 UBD NEU3 USP37 GMPPB GMPPA ARSL USP47 USP48 ARSJ USP49 USP42 NEU1 USP44 SAFB ARSK USP14 USP16 ARSH USP12 ABRAXAS2 ARSI ARSF USP19 USP24 USP25 ARSG USP26 USP20 USP22 ARSD USP28 ARSB NEURL2 CTSA IGF2 GLB1 ST6GALNAC2 RPN2 TUSC3 PRKCSH RPN1 MAGT1 ZDHHC2 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS DDOST HNRNPK MGAT4C DAD1 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 APH1A PSENEN APH1B B4GALT1 INS SLC35A1 SLC35C1 MUC13 GGCX AXIN2 CKAP4 KTN1 TRMT112 TTLL10 TPGS1 TTL TPGS2 TUBB8 SVBP AGTPBP1 LRRC49 NICN1 TUBB8B VASH2 VASH1 TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 TTLL1 AGBL3 AGBL2 TTLL13 TTLL11 TTLL12 TTLL9 TTLL8 GMDS FCSK FPGT FUOM GFUS DCAF13 NOP58 MSRA PAPPA2 IGFALS PCMT1 MSRB2 MSRB3 MSRB1 IGFBP2 IGFBP6 PAPPA KLK1 MRTFA AR DYNC1LI1 DYNC1LI2 CDCA8 RHOT1 HNRNPC DYNLL2 LRRC41 INCENP GPS1 RAB4A RAB13 STX5 MEN1 COPS4 COPS2 ARFGAP3 RANGAP1 ARFGAP2 BIRC5 RNF20 NPPA GALNT12 CFTR POMT2 POMT1 C1GALT1C1 LARGE1 POMGNT1 C1GALT1 B4GAT1 KLK3 SCFD1 SPTBN1 STAM PCSK1 CDX2 GRP GPR119 DPP4 SPCS3 SPCS2 SPCS1 FFAR4 FFAR1 SEC11A SEC11C HDAC4 L3MBTL2 SATB2 SPTAN1 ZBED1 NCOA2 EIF5A DHPS EIF5A2 DOHH TNC DMP1 LGALS1 EVA1A CCN1 CHGB IGFBP1 IGFBP5 IGFBP4 APLP2 SHISA5 PDIA6 DYNC1I1 MXRA8 SPARCL1 SCG3 SCG2 TGOLN2 STC2 PENK IGFBP7 AMELX RAB9A WFS1 AMBN TMEM132A RAB9B BMP4 TF CALU HRC FBN1 SERPINA10 MIA3 CHRDL1 PRSS23 BMP15 ANO8 MEPE RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 GAS6 MATN3 ITIH2 STAM2 AFP FSTL1 FSTL3 SPP2 APOL1 LAMB2 GOLM1 NUCB1 NOTUM H2AW H2AC17 H2AC12 H2AC1 H2BC18 H2AC21 POLB SENP1 ERO1A MUL1 NPLOC4 AURKB UBXN7 VHL UFD1 TOP2A COL7A1 TNIP2 ADRB2 ADRA2C ADRA2A RNF152 SHPRH PEX2 RNF40 RNF144A SELENOS WAC DERL1 TMEM129 HLTF PEX10 PEX12 PEX14 RNF181 GALNT3 PIAS3 TOPORS KDM1B ABCA3 NFRKB ACTR5 ACTL6A ACTR8 INO80C INO80B TTF1 INO80E INO80D COPS7B COPS7A DNMT3B TFPT MCRS1 INO80 COPS3 COPS6 COPS5 COPS8 NUS1 DHDDS DNMT1 SUDS3 GALNT1 USP10 CES1 CP DNAJC3 MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 N6AMT1 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 TPST2 MRPS18B TPST1 MRPS2 MRPS18A MRPS21 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPL43 MRPS5 MRPS18C TUFM MRPL44 MRPL52 OXA1L MRPL53 MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPS33 MRPL18 MAT2B MRPL19 MRPS34 MRPS31 MRPL16 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 SEL1L MRPL12 DERL2 MRPL57 OS9 MRPL13 SYVN1 MRPL54 MRPL10 MRPL11 MRPL55 TOMM20 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 CDC25A AREG IDE TGFA ESR1 ACE2 HSPA8 ANK1 CGB8 UCHL1 SENP8 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ADRM1 ASXL1 ASXL2 NAPA GFPT1 GOLGB1 ALG11 ARRB1 ARRB2 SRD5A3 FN1 MPI PMM2 DOLK PIGS LY6K CPM PIGU INHBB PGAP1 INHBA PIGT INHA PIGO INHBC INHBE PSCA PIGN GPAA1 PIGP PIGZ MSLN PIGW PIGV PIGY PRSS21 PIGX ALG2 FCGR3B PRND TECTA TECTB CD52 PLAUR IZUMO1R ARF3 RTN4RL2 PIGC DPM1 DPM2 PIGB DPM3 CEACAM7 NRN1L RTN4RL1 CEACAM5 CD109 PIGA LY6D PIGK PIGM SPACA4 PIGL PIGG LY6H PIGF GPLD1 PIGH LY6E NRN1 NTM TEX101 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 ART4 LYPD8 OTOA LY6G6C LY6G6D OPCML NTNG1 NTNG2 CNTN5 NEGR1 LSAMP GP2 PLET1 BST1 PRSS41 XPNPEP2 RAET1G LYPD6B RAET1L ALPL CNTN3 MELTF CNTN4 FOLR2 ULBP2 MDGA2 ALPG RECK MDGA1 SPRN TRIM27 PPARG NR3C2 SUZ12 RNF146 SMAD1 TNKS FOXO4 BGLAP PTEN CHD3 DPAGT1 ALG8 ALG9 ALG6 USP13 ALG14 MTA1 ALG13 ALG3 TNKS2 ALG12 ALG1 MPDU1 RFT1 OTUD3 SMAD4 ARF1 SFTPD SQSTM1 RIPK2 NOD1 NOD2 CALR RARA RXRA SNX3 ISL1 PPARGC1A TMED2 TRRAP PPARA USP8 YY1 USP34 SPTB ETF1 ANK2 ANK3 STX1A EPAS1 GSPT2 GSPT1 ST8SIA4 TFG ST8SIA2 NCOA1 NR5A1 PABPC1 KLK13 COPZ2 COPZ1 ARF5 USO1 GGA2 GGA1 GGA3 LMAN2 CHML TRAPPC10 ARCN1 RAB43 RAB41 SPTA1 RAB32 RAB30 RAB36 RAB35 RAB38 RAB6B TRAPPC2 SEC16B TRAPPC3 TRAPPC4 SEC16A TRAPPC5 TRAPPC9 CNIH1 CNIH2 CNIH3 MCFD2 PPP6R1 BET1L ARFGAP1 SEC22A SEC22C RAB1A RAB1B RAB21 RAB12 FOLR1 BET1 KDELR1 COG8 COG7 COG6 LMAN1L COG5 COG4 COG3 COG2 COG1 PREB KDELR2 KDELR3 LMAN2L RAB39A RAB39B RAB27B MIA2 TMED3 TMED7 RAB8B TMED9 RAB33A RAB33B RAB7B NAPB HIF3A STX17 ELOB NAPG ELOC RAB11B SEC23IP PAX6 COPG2 COPG1 TRAPPC2L SEMA5A TBC1D20 CDH2 COPB2 COPA TMED10 MAN2A2 IAPP CUL2 TMEM115 COPE MAN1A2 MAN1A1 WDR5 TRAPPC6A TRAPPC6B GORASP1 GOSR2 GOSR1 MAN1C1 GALNT2 RBBP5 KLF4 LEP DAG1 SPTBN4 SPTBN5 SPTBN2 SIAH2 SIAH1 AGT P2RY2 USP33 GNAT3 CALCA LHB CRHR2 CGA TSHB FSHB GIP ADORA2A ADORA2B GCG POMC LRR1 CCNF KEAP1 CALB1 NAT8B BACE1 APCS TSPAN33 FBXO7 TSPAN5 SNCA ODAM FBXO9 SNCAIP SORL1 WSB1 TSPAN15 FBXO2 NAT8 RNF123 TGFBI ITM2B UBE2J2 GRIA1 FBXL8 FBXL4 FBXL7 GAN B4GALT2 CALM1 B4GALT3 KLHL2 KLHL3 KLHL9 SPSB2 B3GNT7 SPSB1 B3GNT4 KBTBD6 B3GNT3 KLHL5 B3GNT2 B4GALT6 KBTBD8 SPSB4 B4GALT4 B4GALT5 FBXO27 CSNK2A1 CSNK2A2 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 CSNK2B FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 KLHL42 UBE2V2 CUL7 CUL5 PCSK2 KLHL11 UCN ERO1B CPA3 KLHL13 FBXO44 MYRIP FBXO41 AOPEP SOCS3 ENPEP FBXO40 CPB1 PLA2G7 CLTRN BTBD1 ACE IGF1 UBE2F ALPI MBOAT4 KLHL25 GZMH SMURF2 ACHE CPE ZBTB16 REN KLHL21 KLHL22 BTBD6 FBXO32 FBXO30 FBXO31 PARK7 KLHL20 UBA3 UBE2M KBTBD13 USP30 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 BCHE FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 PNPLA2 ASB6 ASB7 CETN2 ASB4 CCP110 ASB5 ASB2 ACTR1A ASB3 TUBA1A ASB1 BTRC RAB8A SKP1 FBXW11 RORA NR3C1 CSNK1D DYNLL1 TUBA4A HIF1A UBA52 NRIP1 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA UBB CTBP1 UBC RPS27A USP4 USP2 DYNC1H1 TUBB4B TUBB4A CDK1 OTUD7B PRL RBX1 BIRC2 BIRC3 GH1 USP21 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 IKBKG MAP3K7 PSMA5 PSMA6 PSMA3 PSMA4 FUCA1 PSMA1 FUCA2 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BCL10 PSMA7 RELA PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 PSMC3 APEH PSMC4 PSMC1 PSMC2 CISH NCOR2 HDAC3 HDAC1 SIN3A HSP90B1 MUC5AC ADAM10 BECN1 HSPG2 TSPAN14 KLK2 ADAMTS16 NCSTN ADAMTS18 C4A LAMC1 ANPEP ADAMTS4 ADAMTS5 ADAMTS1 TRIM28 CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 MMP1 RAB27A MMP2 MYO5A PLG FURIN MUC12 MUC15 SPP1 CMA1 LAMB1 H2AX H2AB1 VDR H2AC19 SEMG1 H2AC14 H2BC12L ACTR10 H2BC21 SRP14 RUVBL1 H2BU1 H2AC8 H2AC6 H2AC7 MUC3A H2BC17 MUC3B H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 MUC16 MUC17 MUC19 RBBP7 H2AZ1 H2BC9 ADA2 MUC20 MUC21 NPM1 H4C9 H2BC8 H2BC5 H2BC3 ATP6AP2 H2BC1 ZNF350 H2AC20 CAND1 MUC5B UBE2D2 UBE2D1 PRKDC CFP CDC34 AHSG GSN RAB3A CSF1 RAB3D RAB44 UBE2N TAB1 RAB31 RAB37 RAB5B RAB5C RAB6A RAB4B TRAPPC1 TRAF6 TTR RAB24 RAB10 RAB18 NR4A2 THRB HLA-B HLA-A NR2C1 RAB3B RAB3C RAB22A RAB42 RAB2A MLEC RAB2B PTP4A2 RAB34 RAB40A RAB40B RAB20 RAB40C RAB25 SEC61G CREBBP RAB26 SEC61B RAB23 RAB29 RAB15 RAB19 RAB17 EIF2B5 EIF2B4 KAT2B EIF2B3 KAT2A EIF2B2 CST3 EIF5 EIF2B1 EP300 EIF5B CAPZA3 IL33 TP53 COPB1 CUL3 NLRP3 KBTBD7 C3 TFAP2B TFAP2C UBE2I SUMO1 OTUD5 APP UBE2D3 MUC1 TNFAIP3 MUC2 UBE2L6 MUC7 IFIH1 MUC4 TRIM4 MUC6 TRIM25 IKBKE TOMM70 DDX58 TRAF2 OTUB2 OTUD7A VCPIP1 TRAF3 ZRANB1 YOD1 TNIP1 RNF128 TNIP3 OTUB1 RNF135 LYZ RIPK1 VAMP2 NFKB2 CYLD MAVS SAA1 UBE2K SKP2 DAXX UBE2C UBE2E1 CPB2 CCNE2 UBE2S SOCS2 SOCS6 SOCS5 CCNE1 SEC22B SEC23A SEC24B SEC24A SEC24D SEC24C EIF4A2 EIF4A1 COMMD9 SEC31A PRKN ATXN3 ATXN3L VCP RAD23A JOSD2 JOSD1 RAD23B SDC2 BPIFB2 VCAN GPC3 CTSZ CTSH QSOX1 CTSC MME COMMD3 APOE APOB GPIHBP1 MBTPS1 APOA2 APOA1 APOA4 APOA5 ALB P4HB CD59 ACTB CD55 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B FBXW2 XRN2 GAPDHS FKBP9 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNAQ GNB2 TBCE GNB1 GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B SEC61A2 GNGT2 SEC61A1 KIF13A CCT3 CCT2 VBP1 SPHK1 TUBB2B TUBB2A DCTN6 TCP1 DCTN5 PFDN1 DCTN1 PFDN2 PFDN4 DCTN4 PFDN5 PFDN6 TUBAL3 USP11 GBA TUBA3E GNA14 AP3M1 TUBA3D GNA15 GNG3 TUBA3C GNG2 GNG5 GNG4 GNA11 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 STAT3 RGS11 SERPINA1 MDC1 NUP107 NUP188 SMC5 SMC6 BRCA1 SMC3 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 80%9717326 crizotinib-resistant ALK mutants ALK DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 80%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP RRNA PROCESSING%REACTOME%R-HSA-72312.3 rRNA processing RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 NSUN4 RPL10 MTERF4 RPL12 TFB1M RPL11 RPL36A MRM1 RPS27L MRM2 RPS4Y1 MRM3 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 DKC1 IMP4 NHP2 RRP7A PDCD11 ERI1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 GAR1 TRMT112 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 RRP36 UTP6 NOP10 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL RPP38 DIMT1 FTSJ3 EBNA1BP2 NCL RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 UTP18 SENP3 C1D DDX21 BMS1 RPP14 DCAF13 NOP58 KRR1 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 CSNK1D EXOSC2 CSNK1E EXOSC1 UBA52 RPS27A RPS6 XRN2 NOP2 TRMT10C ELAC2 PRORP HSD17B10 SNU13 RPL4 RPL5 NOP56 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 MTREX ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.1 Activated NTRK2 signals through FYN BDNF NTRK2 GRIN2B RAC1 DOCK3 SRC CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 80%5357769 Caspase activation via extrinsic apoptotic signalling pathway FAS UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 CASP8 TICAM2 APPL1 CASP3 TICAM1 TRAF2 TNFSF10 MAGED1 LY96 RIPK1 CD14 FADD DCC TNFRSF10B TNFRSF10A TLR4 TRADD FASLG HEME SIGNALING%REACTOME DATABASE ID RELEASE 80%9707616 Heme signaling NCOR1 TBL1XR1 HELZ2 NFE2L2 PSPHP1 APOA1 TBL1X HMOX1 CLOCK NPAS2 CREBBP ARNTL RAI1 SIRT1 HBA2 SMARCD3 NRIP1 PPARGC1A CARM1 NR1D1 CLEC1B EP300 MED1 CREB1 SLC46A1 XPO1 BACH1 MAFK NCOA2 CHD9 LY96 NCOA1 HBB NCOA6 PPARA TLR4 RXRA CRTC2 CRTC3 CRTC1 ATF2 RORA MEF2D MEF2C HDAC3 TGS1 APOB NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.1 NEIL3-mediated resolution of ICLs NEIL3 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 80%5654743 Signaling by FGFR4 GAB1 PIK3R1 UBA52 CBL KLB NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 FGF1 FGF2 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 BRAF PPP2CA PPP2CB MKNK1 RPS27A MAPK1 FGF19 SPRY2 MAPK3 FGFR4 PPP2R1A FGF16 FGF18 PTPN11 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME%R-HSA-5688890.2 Defective CSF2RA causes SMDP4 SFTA3 CSF2RB SFTPB CSF2RA SFTPC SFTPD SFTPA2 SFTPA1 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 80%5655253 Signaling by FGFR2 in disease GAB1 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS POLR2A FRS2 POLR2B GTF2F1 FGF1 POLR2C GTF2F2 FGF2 POLR2D FGF3 FGF4 POLR2E FGFR2 FGF6 POLR2F FGF9 POLR2G FGF20 POLR2H POLR2I FGF23 POLR2J FGF22 POLR2K FGF10 POLR2L FGF16 FGF7 NCBP1 NCBP2 FGF18 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 80%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.1 Defective NTHL1 substrate binding NTHL1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 80%9664535 LTC4-CYSLTR mediated IL4 production GGT1 GGT5 DPEP2 DPEP1 DPEP3 CYSLTR1 CYSLTR2 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013422 RHOBTB1 GTPase cycle CCT7 PDE5A CCT2 CUL3 TXNL1 GPS1 COPS4 ROCK2 MYO6 COPS2 TRA2B RBBP6 HNRNPC SRRM1 SPEN RNF20 RBMX ROCK1 RHOBTB1 CPSF7 DBN1 STK38 VIM NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 80%198725 Nuclear Events (kinase and transcription factor activation) NAB1 RPS6KA2 NAB2 RPS6KA1 TPH1 ATF1 ID1 TCF12 EGR1 SH3GL3 ARC TRIB1 RRAD MAPKAPK2 EGR3 EGR4 FOSL1 ID2 ID4 EP300 ID3 LYL1 MAPK14 ASCL1 CDK5R2 FOS PPP2CA PPP2CB MAPK1 MAPK3 PPP2R1A DUSP4 DUSP3 PPP2R5D CHD4 VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B JUND MAPK11 REST CDK5R1 FOSB F3 JUNB ELK1 CREB1 EGR2 CDK5 VGF SRF DNM2 ATF2 MEF2A SGK1 MEF2C MEF2D RPS6KA3 RPS6KA5 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 80%110329 Cleavage of the damaged pyrimidine H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 NTHL1 H2AC7 H2BC17 H2BC12 H2BC13 MBD4 H2BC14 SMUG1 H2AJ H2BC15 NEIL2 H2BC11 NEIL1 OGG1 H2AZ1 H2BC9 H2AZ2 TDG ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.4 Positive epigenetic regulation of rRNA expression HDAC2 ACTB H3C15 DDX21 KAT2B KAT2A EP300 MBD3 GATAD2B GATAD2A CHD4 CHD3 MTA1 MTA2 DEK MTA3 MYBBP1A BAZ1B HDAC1 H2AX H3-3B H2AB1 TTF1 H2AC19 H2AC14 H2BC12L H2BC21 TBP H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 H2AJ H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E POLR2F TAF1A RBBP4 POLR2H RBBP7 H2AZ1 POLR2K H2BC9 POLR2L H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 SF3B1 H2AC20 GSK3B EHMT2 CBX3 H3C8 ERCC6 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 80%5682294 Defective ABCA12 causes ARCI4B ABCA12 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.1 MAPK targets Nuclear events mediated by MAP kinases RPS6KA2 RPS6KA1 ATF1 MAPKAPK2 ELK1 MAPK14 CREB1 JUN FOS PPP2CA MAPK9 PPP2CB MAPK8 MAPK10 MAPK1 MAPK3 PPP2R1A DUSP4 DUSP3 PPP2R5D VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B MAPK11 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.7 Degradation of cysteine and homocysteine TXN2 CTH SLC25A10 GADL1 CSAD ADO MPST TSTD1 SQOR GOT2 SUOX TST ETHE1 CDO1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.6 Vitamin D (calciferol) metabolism LRP2 SUMO2 UBE2I VDR PIAS4 GC CYP27B1 LDLRAP1 LGMN CUBN CYP24A1 CYP2R1 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 80%167590 Nef Mediated CD4 Down-regulation AP2M1 LCK ARF1 CD4 AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.5 Organelle biogenesis and maintenance CALM1 TFB1M CHD9 C2CD3 TCTN3 TCTN2 TCTN1 MAPK11 CC2D2A IQCB1 KIF24 TMEM216 FBF1 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 B9D1 CEP89 MAPK12 MED1 TFAM TFB2M IFT172 POLRMT DYNC2H1 RPGRIP1L IFT88 SMO KIF3A TTC21B TNPO1 IFT122 MKS1 IFT52 IFT57 IFT140 ATF2 WDR35 WDR19 CREBBP TRIP11 MAPK14 PPARGC1B CEP57 ESRRA YWHAE CETN2 CEP164 CCP110 ACSS2 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 CRTC2 CRTC3 CRTC1 TUBB CEP131 HAUS4 KIFAP3 HAUS3 HAUS6 TGS1 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 DYNC2I2 HAUS2 DYNC2I1 TUBA4A TRAF3IP1 HAUS1 IFT80 AKAP9 IFT81 CEP63 DYNC2LI1 MAPRE1 HSPB11 SFI1 DYNLT2B ATAT1 TTC30B SMARCD3 SDCCAG8 TTC30A CEP97 NR1D1 PAFAH1B1 KIF3B IFT20 DYNC1I2 IFT22 IFT27 DCTN2 SSNA1 KIF3C DYNLRB2 DYNLRB1 DCTN3 TTC26 DYNLT5 DYNLT2 IFT43 IFT46 HAUS8 IFT74 HAUS7 CLUAP1 PRKAR2B CEP70 CEP72 CEP192 PCNT HSPA9 CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 SOD2 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 MEF2C ALAS1 MICOS13 DYNLL2 MICOS10 CHCHD6 MTERF1 HELZ2 GABPA TWNK SIRT4 SIRT5 PPRC1 POLG2 PERM1 NRF1 APOO PRKAA2 APOOL IDH2 DNAJC11 PRKAG1 IMMT GLUD1 PRKAG2 GLUD2 PRKAG3 TMEM11 SSBP1 PRKAB2 PRKAB1 CYCS RXRA HDAC3 NCOR1 TBL1XR1 CAMK4 TBL1X PPARGC1A KIF17 CHCHD3 ATP5MC1 ARL13B INPP5E PDE6D PPARA DMAC2L ATP5PF ATP5PD ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATP5F1D MEF2D ATP5F1E MT-ATP8 MT-ATP6 ATP5PO ATP5MG ATP5MF ATP5ME HDAC6 ATP5F1A NCOA2 ATP5F1B MTX2 HCFC1 SAMM50 CCT3 CCT2 ARF4 PKD2 PKD1 TCP1 CNGA2 BBS9 MTX1 CNGA4 BBS7 BBS5 BBS4 MKKS EXOC8 CARM1 EXOC7 B9D2 CYS1 SSTR3 LZTFL1 BBS10 RP2 BBS12 EXOC4 EXOC3 CREB1 EXOC6 EXOC5 EXOC2 CNGB1 EXOC1 UNC119B CCT8 ARL6 CCT5 ARL3 CCT4 ASAP1 MCHR1 RHO NPHP3 RAB11FIP3 BBS2 BBS1 RAB3IP GBF1 BBIP1 NCOA1 RAB11A TTC8 NCOA6 SIRT3 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 80%8866423 VLDL assembly MTTP APOC4 P4HB APOC1 APOB ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 80%6803157 Antimicrobial peptides ELANE DEFB129 DEFB128 DEFB1 DEFB127 PGLYRP4 DEFB126 PGLYRP3 DEFB125 PGLYRP2 DEFB124 DEFB123 DEFB121 DEFB107B PGLYRP1 S100A7A PLA2G2A LCN2 S100A9 GNLY DEFB119 S100A8 DEFB118 LTF DEFB117 S100A7 DEFB116 HTN1 CTSG DEFB115 HTN3 DEFB136 DEFB114 DEFB135 DEFA6 DEFB134 DEFB113 DEFA4 DEFB133 DEFB112 DEFA5 DEFB132 DEFB110 DEFA3 DEFB108B DEFB108C ATP7A EPPIN CLU DEFB109B CD4 PI3 TLR1 TLR2 ATOX1 DCD ITLN1 CAMP DEFB4B BPIFA1 BPIFA2 SLC11A1 DEFB103B REG3A REG3G ART1 SEMG1 DEFA1B DEFB104B CHGA PDZD11 LEAP2 RNASE6 RNASE3 PRTN3 BPIFB2 BPIFB1 BPIFB4 BPIFB6 DEFB105B PRSS2 LYZ BPI CCR6 CCR2 DEFB106B DEFB130A RNASE8 RNASE7 DEFB130B PRSS3 DEFB131A GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.2 Glutathione conjugation GSTM1 GSTM5 GSTA3 OPLAH GGT5 GSTO2 AKR1A1 GSTA1 MGST1 GGT7 GGT6 GSTZ1 GSTA5 GSTA4 GSS GSTP1 GGT3P GSTO1 HPGDS GCLC CHAC2 CHAC1 GCLM GSTK1 GSTA2 GGT1 MGST3 MGST2 GSTT2 ESD GSTT2B GSTM4 GSTM3 GSTT1 GSTM2 GGCT RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.1 RHO GTPases activate PKNs PKN3 YWHAB KLK3 MYL12B YWHAQ H3C15 YWHAH PKN2 YWHAZ PKN1 YWHAE PPP1CB NCOA2 RHOC RHOB CDC25C YWHAG KDM1A KDM4C PPP1R12A H2AX H3-3B PAK1 H2AB1 PDPK1 H2AC19 H2AC14 RAC1 H2BC12L H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 AR H2AJ H2BC15 H2BC11 MYL6 MYL9 H2AZ1 H2BC9 H2AZ2 RHOA H4C9 PPP1R12B H2BC8 H2BC5 H2BC3 SFN H2BC1 MYH9 H2AC20 PPP1R14A MYH14 KLK2 MYH11 MYH10 H3C8 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 80%8985801 Regulation of cortical dendrite branching ROBO2 NCK2 ROBO1 SLIT1 HEMOSTASIS%REACTOME DATABASE ID RELEASE 80%109582 Hemostasis TLN1 RAF1 VCL ACTN2 SRC CD9 CALM1 TBXA2R TREM1 PLAUR CEACAM5 CD109 INPP5D PIK3R6 IGF1 CEACAM3 CEACAM1 CEACAM6 CEACAM8 ALDOA PLA2G4A ITGA3 SIRPA MGLL PRKCE HSPA5 SLC16A8 SLC16A3 PLCG2 VAV3 SYK LCP2 PPP2R1A PRKACA ITGA6 PLAT TRPC7 TRPC6 SERPINE1 TRPC3 SLC7A11 SLC7A10 SLC7A5 SLC7A6 SLC7A9 TUBA4A SLC7A7 SLC7A8 ANGPT4 ANGPT2 ANGPT1 DOK2 GRB14 TEK PRKCD SLC3A2 ISLR PRKAR2B CHID1 SERPINF2 GTPBP2 SYTL4 NHLRC2 ENDOD1 S100A10 SERPINB2 PRKCZ VTI1B ANXA2 HRG FERMT3 SERPINA4 TMSB4X TIMP3 MIF ANXA5 SERPINB8 SOD1 PCYOX1L DGKG DGKE DGKD DGKB TNFRSF10B DGKA TNFRSF10A DGKZ TNFRSF10D DGKQ DGKK TTN PPIA DGKI DGKH SCCPDH PTPN11 WDR1 PHACTR2 ITIH4 ITIH3 CLEC3B CDC37L1 JAK2 HABP4 ACTN4 PRKCG TAGLN2 PRKCA TEX264 APOH MANF TSPAN7 MAGED2 PICK1 ECM1 OLA1 CTSW TOR4A STXBP3 LY6G6F CXADR APOOL LHFPL2 POTEKP PRKCB FAM3C TMX3 SELENOP FLNA RARRES2 CYRIB LGALS3BP PLEK SRGN MMRN1 AKT1 PRKCH OLR1 RAPGEF3 RAPGEF4 STX4 CFL1 BRPF3 TGFB1 ITGB1 JAML MPL THPO HDAC1 SIN3A DOCK10 SHC1 EGF PIK3R1 NRAS PIK3CA PLCG1 ITGAM L1CAM SOS1 HRAS ITGB2 ITGAL VAV2 ITGAX BSG ITGA4 PIK3R2 RACGAP1 CSK PCDH7 LEFTY2 CAV1 ACTN1 A2M PFN1 MAG GRB7 CYB5R1 PIK3R3 TIMP1 PTK2 MMP1 PPBP ITGAV RAC2 IGHM RHOG ITGA5 CD44 RHOB PPP2R5D PLG PPP2R1B SERPINE2 SERPINC1 PROS1 F13A1 PRCP FCER1G TFPI KNG1 SERPINA5 THBD C1QBP PF4V1 CD177 FGB FGA KLKB1 VWF F10 APLP2 SERPIND1 GP1BB F12 F2R F11 SCG3 FGG GP1BA F2 F3 SPARC GP5 PLAU F5 GP9 F7 PROCR F8 TF PROC F9 CALU SERPING1 PRTN3 F13B PF4 GAS6 IGHA1 CD36 IGHA2 CAP1 SPP2 GNA12 IGHV3-23 IGLV IGLV2-8 IGKV1-16 ABCC4 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 TGFB2 IGKV2D-28 TGFB3 IGKV4-1 AHSG IGHV7-81 PRKCQ V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP1 IGLV2-11 YWHAZ IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN CLU V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 GNA13 LAMP2 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 H3-3B PDPK1 V1-3 IGKV3D-20 V5-6 LAT IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRK IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB YES1 PRKAR1B PRKAR1A KIF3A GUCY1B2 PRKAR2A GUCY1B1 ATP2A3 RAB27B ATP2A2 ATP2A1 SLC8A1 SLC8A2 GNAS PPP2R5E PRKG2 NOS1 JCHAIN GUCY1A2 GUCY1A1 PTGIR IRAG1 PPP2R5B PPP2R5A PPP2R5C STXBP2 FGR STIM1 KCNMA1 PECAM1 ORAI2 ORAI1 PDE5A PDE9A PDE1B PDE1A ITPR1 ITPR2 ADRA2C ORM1 ITPR3 ORM2 SRI ADRA2B LRP8 ADRA2A PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 NOS2 NOS3 PDE2A PDPN CLEC1B ATP2B4 MPIG6B ATP2B3 GP6 ATP2B2 ATP2B1 MAPK14 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 TP53 PDE10A P2RX4 P2RX3 P2RX2 P2RX1 PTPN6 SELL F11R CFD KIF28P KDM1A JMJD1C DOCK11 KIF5C KIF5B KIF5A MYB IFNA5 JAM2 KIF21A IFNA4 JAM3 KIF21B APP KIFAP3 IFNA7 HBE1 IFNA6 KIF16B KIF20A KIF20B ZFPM2 IFNA2 ZFPM1 GATA6 GATA5 AK3 IFNA8 GATA4 GATA3 KLC1 GATA2 GATA1 PHF21A KLC4 KLC3 KLC2 KIF3B MICAL1 IFNA13 ABL1 IFNA14 KIF3C NFE2 IFNA16 CARMIL1 IFNA17 CBX5 HBG2 HBG1 EHD1 EHD2 KIF18A EHD3 KIF18B CDK5 IFNA10 KIF4B KIF4A MAFG MAFF MAFK RAB5A RCOR1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 DOCK7 IFNA21 HBB KIF12 KIF11 IFNB1 HBD KIF15 AKAP10 ATP1B3 KIF19 ATP1B2 CAPZB ATP1B1 KIF13B KIF1C HMG20B KIF1B KIF1A H3C8 ITPK1 KIF25 KIF23 KIF22 KIF6 RBSN KIF27 RAD51B KIF9 RAD51C KIFC2 KIF2A KIFC1 IRF1 IRF2 KIF2C KIF2B DOCK2 DOCK1 HDAC2 AKAP1 H3C15 MFN1 MFN2 SH2B3 SH2B2 SH2B1 CABLES1 CABLES2 CENPE CDK2 WEE1 KIF26A CAPZA1 KIF26B CAPZA2 VPS45 PPP2CA P2RY12 PPP2CB SLC16A1 SPN MAPK1 PPIL2 MAPK3 F2RL2 F2RL3 AAMP PTPN1 ABHD12 DAGLA ABHD6 DAGLB CDC42 LCK FYN RAC1 PIK3CG PIK3R5 VAV1 SDC4 SDC2 SDC3 GPC1 P2RY1 SDC1 THBS1 RHOA QSOX1 CD47 APOB CD63 PIK3CB APOA1 ALB HGF PDGFB CD58 GNAT3 CD74 PSAP GNG10 GNG12 GNG11 GNG13 GNAQ ITGA2 GNB2 ITGA10 ITGA1 CD99 GNB1 GNB4 IGF2 GNB3 VPREB3 VPREB1 PSG1 GNB5 PSG3 PSG2 PSG9 FCAMR GNGT1 BCAR1 PSG8 PSG5 PSG4 GNGT2 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 CD48 SELPLG EPCAM IGLL1 CD84 SIRPG GNAI3 PSG11 SELE SELP ESAM GNAI1 MERTK GNAI2 GNA14 CD2 CD244 GNA15 GNG3 GNG2 A1BG GNG5 GNG4 GNA11 GNG7 GNG8 SERPINA3 SERPINA1 ITGB3 ITGA2B ARRB1 VEGFB ARRB2 VEGFC RAP1B VEGFD RAP1A VEGFA FN1 SERPINB6 APBB1IP DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 80%3769402 Deactivation of the beta-catenin transactivating complex BCL9L HDAC1 BCL9 CHD8 CBY1 UBA52 KMT2D TLE4 TLE2 XIAP TLE1 AKT2 RBBP5 AKT1 UBB CTBP1 YWHAZ UBC SOX3 TCF7L2 XPO1 TCF7L1 RPS27A TCF7 SOX17 LEF1 SOX2 SOX6 SOX7 CTNNB1 SOX4 SOX9 SOX13 MEN1 BTRC TLE3 SRY APC CTNNBIP1 ASH2L PYGO1 PYGO2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.2 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LIPID PARTICLE ORGANIZATION%REACTOME%R-HSA-8964572.1 Lipid particle organization HILPDA FITM1 FITM2 CIDEA HSD17B13 CIDEC DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 80%4724325 Defective ALG8 causes CDG-1h ALG8 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 80%1299316 TWIK-releated acid-sensitive K+ channel (TASK) KCNK9 KCNK3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 80%180786 Extension of Telomeres PCNA POLD3 POLD4 POLD1 POLD2 RFC5 RFC3 CDK2 RFC4 LIG1 BLM RFC1 RFC2 RPA2 WRN RPA3 RPA1 WRAP53 FEN1 DSCC1 CHTF18 PPP6C RUVBL2 PPP6R3 TINF2 TERF1 TERF2 CCNA2 CCNA1 SHQ1 DKC1 NHP2 RUVBL1 POT1 TERF2IP DNA2 PIF1 PRIM2 RTEL1 PRIM1 CHTF8 TERT GAR1 CTC1 ANKRD28 STN1 ACD POLA1 POLA2 TEN1 NOP10 CARNITINE METABOLISM%REACTOME DATABASE ID RELEASE 80%200425 Carnitine metabolism SLC25A20 MID1IP1 SLC22A5 THRSP CPT1A RXRA PPARD PRKAA2 PRKAB2 CPT1B CPT2 PRKAG2 FLT3 SIGNALING%REACTOME%R-HSA-9607240.6 FLT3 Signaling FLT3 LCK SLA2 FYN AKT3 FLT3LG GAB2 PIK3R1 UBA52 CBL HCK NRAS PIK3CA SOS1 AKT2 SH2B3 HRAS SOCS2 FOXO3 SOCS6 GRAP2 AKT1 UBB GRB10 SYK UBC PTPRJ RPS27A BCL2L11 CSK ABL2 SLA STAT5A STAT5B PTPN11 CDKN1B DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 80%69190 DNA strand elongation DNA2 PRIM2 PCNA POLD3 PRIM1 POLD4 POLD1 POLD2 RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 RPA3 POLA1 POLA2 GINS1 GINS2 RPA1 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 FEN1 MCM6 MCM2 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.3 Signaling by Hedgehog PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 ULK3 PSME2 DZIP1 EFCAB7 PSMD10 IQCE EVC PSMB11 PSMD12 GAS8 PSMD11 SPOP PSMD14 EVC2 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 DISP2 SCUBE2 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DHH VCP SEL1L DERL2 ERLEC1 OS9 SYVN1 SMURF2 SMURF1 IFT172 PRKACG PRKACB GPC5 DYNC2H1 RPGRIP1L IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 INTU KIF3A TTC21B PRKAR2A ADAM17 PTCH1 IFT122 FUZ ADCY10 MKS1 GNAS GSK3B GLI1 GLI3 GLI2 IFT52 CDC73 SUFU IFT57 IFT140 KIF7 WDR35 NUMB ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 WDR19 ITCH P4HB SHH HHIP BOC IHH GAS1 CUL3 GRK2 BTRC PRKACA SKP1 OFD1 HHAT UBA52 CUL1 UBB PRKAR2B UBC RPS27A CDON NOTUM ARRB1 ARRB2 RBX1 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.1 Interleukin-27 signaling IL6ST CRLF1 CANX JAK1 STAT3 IL27RA EBI3 STAT1 TYK2 IL27 JAK2 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 80%5626467 RHO GTPases activate IQGAPs CDC42 IQGAP1 CLIP1 IQGAP2 CTNNA1 CTNNB1 IQGAP3 RAC1 MEN1 CALM1 CDH1 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 80%5654710 PI-3K cascade:FGFR3 FGF16 GAB1 FGF18 PIK3R1 PIK3CA FRS2 PTPN11 FGF1 FGF2 FGF4 FGF9 FGF20 FGF23 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 80%1839120 Signaling by FGFR1 amplification mutants INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.6 Interleukin-4 and Interleukin-13 signaling RORC PIM1 CCL22 CCND1 HMOX1 IL4 FSCN1 ZEB1 IL13 IL18 AKT1 SOCS5 IL1A IL1B ALOX5 JAK3 MYC NDN IGHG4 IGHG1 CCL2 IL6R IL13RA2 IL13RA1 TGFB1 ITGB1 STAT6 VIM MCL1 MAOA BCL6 HSP90B1 BCL2L1 COL1A2 IGHE PIK3R1 LBP ITGAM SOCS3 SOCS1 NANOG ITGB2 ITGAX OPRD1 BIRC5 TNFRSF1B IL23R IL10 IL6 IL2RG BATF IL23A TWIST1 ICAM1 LIF HGF LCN2 CXCL8 NOS2 TIMP1 TNF OPRM1 S1PR1 TP53 MMP1 IL17F FOS MMP2 MMP3 IL17A MMP9 ALOX15 FOXO1 POU2F1 HSPA8 LAMA5 RHOU HSP90AA1 F13A1 RORA IRF4 MUC1 OSM GATA3 HIF1A STAT1 CEBPD IL4R JUNB FOXO3 ANXA1 FGF2 BCL2 VCAM1 POMC IL12B IL12A JAK1 SOX2 STAT3 TYK2 CD36 FASLG SAA1 PTGS2 VEGFA CDKN1A FN1 FCER2 JAK2 CCL11 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 80%9734091 Drug-mediated inhibition of MET activation HGF MET SYNTHESIS OF GDP-MANNOSE%REACTOME%R-HSA-446205.1 Synthesis of GDP-mannose PMM1 MPI PMM2 GMPPB GMPPA BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors IGKV1-17 IGKV1-12 HP IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 AMBP V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 CALR IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 HYOU1 IGHV4-39 IGHV SCARF1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 LRP1 V1-9 V5-4 V1-7 FTL V5-1 V1-5 V1-3 HSP90B1 COL1A1 IGKV3D-20 V5-6 COL3A1 COL1A2 COL4A2 IGLV3-19 IGKV2-30 COL4A1 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 MSR1 IGLV3-27 SCARA5 IGKC MARCO IGKV1-39 SCGB3A2 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD163 FTH1 JCHAIN APOE APOB APOA1 ALB HBA2 HSPH1 MASP1 SSC5D HSP90AA1 COLEC12 COLEC11 SPARC STAB1 STAB2 HPR HPX IGHA1 CD36 IGHA2 HBB APOL1 SAA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 80%6791226 Major pathway of rRNA processing in the nucleolus and cytosol RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 LTV1 RRP1 FCF1 PWP2 RRP9 IMP3 WDR75 IMP4 RRP7A PDCD11 ERI1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 RRP36 UTP6 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL RPP38 FTSJ3 EBNA1BP2 NCL RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 UTP18 SENP3 C1D DDX21 BMS1 RPP14 DCAF13 NOP58 KRR1 XRN2 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 CSNK1D EXOSC2 CSNK1E EXOSC1 UBA52 SNU13 RPL4 RPS27A RPL5 NOP56 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 MTREX RPL37 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 80%209543 p75NTR recruits signalling complexes IKBKB NGFR PRKCI RPS27A NGF IRAK1 TRAF6 SQSTM1 UBA52 MYD88 RIPK2 UBB UBC COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%196783 Coenzyme A biosynthesis PPCS PANK4 PANK2 PANK3 PANK1 COASY PPCDC SLC25A16 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 80%5336415 Uptake and function of diphtheria toxin HSP90AB1 HSP90AA1 TXNRD1 HBEGF CD9 EEF2 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 80%1855231 Synthesis of IPs in the ER lumen MINPP1 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.2 Ub-specific processing proteases RNF123 USP15 H2AW H2AC17 H2AC12 H2AC1 H2BC18 SMAD7 H2AC21 POLB MUL1 UFD1 TAB1 AXIN2 CCNA2 CCNA1 TRAF6 SMURF2 ADRB2 USP30 KAT2A IL33 USP18 RNF146 TP53 SMAD1 TNKS CCP110 FOXO4 PTEN SMAD2 SMAD3 USP13 TNKS2 GATA3 HIF1A IFIH1 UBA52 TOMM70 SMAD4 DDX58 AR TRAF2 UBB UBC SUDS3 RNF128 RPS27A USP4 OTUB1 USP2 USP10 RHOT1 DDB2 RIPK1 CYLD BIRC2 BIRC3 TAF9B USP21 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SIAH2 IKBKG SKP2 MAP3K7 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYC PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 HGS PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 TGFBR1 PSMC3 MDM2 PSMC4 MDM4 PSMC1 PSMC2 PTRH2 ATXN7 SNX3 TAF10 MAT2B VDAC3 VDAC2 VDAC1 TOMM20 TRRAP USP17L4 USP17L5 USP17L8 CDC20 TADA2B USP33 WDR20 BECN1 USP17L3 USP17L1 CDC25A USP3 FKBP8 TADA3 USP8 USP17L30 USP34 CFTR IDE USP17L21 USP17L20 USP17L22 USP17L15 USP17L18 USP17L17 USP17L19 USP17L10 USP17L12 USP17L11 USP17L13 USP7 CLSPN USP5 USP37 USP9X USP47 USP48 USP49 USP42 USP44 USP14 USP16 USP12 USP19 USP24 USP25 USP26 USP20 USP22 USP28 AXIN1 RCE1 ADRM1 H2AC19 USP17L2 H2AC14 H2BC21 RUVBL1 H2BU1 H2AC8 USP11 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 WDR48 H2BC9 H2BC8 STAM2 H2BC5 H2BC3 H2BC1 H2AC20 KEAP1 ARRB1 ARRB2 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME%R-HSA-167238.2 Pausing and recovery of Tat-mediated HIV elongation ELOB ELOC TCEA1 SSRP1 CCNT1 POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE ELOA2 SUPT5H CDK9 ELL ELOA SIGNAL ATTENUATION%REACTOME%R-HSA-74749.3 Signal attenuation INSR IRS1 MAPK1 SOS1 IRS2 MAPK3 SHC1 GRB10 INS SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.2 Senescence-Associated Secretory Phenotype (SASP) RPS6KA2 ANAPC11 RPS6KA1 FZR1 CDC23 CDC26 CDC27 VENTX ANAPC7 UBE2C CXCL8 UBE2E1 H3C15 CDK6 UBE2S CDK4 IL1A CDC16 CDK2 ANAPC4 ANAPC5 JUN ANAPC1 ANAPC2 FOS RELA MAPK1 MAPK3 NFKB1 MAPK7 CDKN2A CEBPB H2AX H3-3B H2AB1 H2AC19 CCNA2 H2AC14 CCNA1 H2BC12L H2BC21 UBA52 IGFBP7 H2BU1 CDKN2D H2AC8 CDKN2B H2AC6 H2AC7 CDKN2C H2BC17 EHMT1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB UBC H2AZ1 H2BC9 RPS27A H2AZ2 STAT3 H4C9 H2BC8 H2BC5 H2BC3 IL6 H2BC1 H2AC20 EHMT2 CDKN1A H3C8 UBE2D1 ANAPC15 CDKN1B RPS6KA3 ANAPC16 ANAPC10 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.3 ABC transporters in lipid homeostasis ABCA12 ABCA10 APOA1 ABCD2 ABCA2 ABCA5 ABCA9 ABCA7 PEX19 ABCD1 ABCG8 ABCG5 ABCG1 PEX3 ABCA6 ABCG4 ABCA3 XENOBIOTICS%REACTOME DATABASE ID RELEASE 80%211981 Xenobiotics CYP3A43 CYP2A7 CYP2A6 CYP3A5 CYP2C9 CYP2C18 CYP2C8 CYP3A7 CYP2B6 CYP2A13 CYP2F1 CYP2W1 CYP2J2 CYP2D6 CYP2S1 ARNT AHR ARNT2 CYP2E1 AHRR CYP3A4 CYP1A1 CYP2C19 CYP1A2 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.3 Extra-nuclear estrogen signaling CCND1 AREG AKT3 PIK3R3 SRC TGFA GNAT3 ESR1 NOS3 ESR2 EPGN AKT2 STRN AKT1 PTK2 MMP7 CALM1 FOS MMP2 MMP3 XPO1 MMP9 MAPK1 MAPK3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 HSP90AA1 GNB3 GNB5 GNGT1 PRMT1 GNGT2 PDPK1 SPHK1 EGF PIK3R1 EGFR GNAI3 NRAS PIK3CA GNAI1 GNAI2 HRAS BTC FOXO3 ELK1 GNG3 UHMK1 CREB1 GNG2 HBEGF GNG5 BCL2 EREG GNG4 GNG7 GNG8 S1PR3 PRKCZ PIK3R2 SRF ZDHHC7 ZDHHC21 IGF1R CAV2 CAV1 CDKN1B MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.4 mRNA 3'-end processing FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB RNPS1 CPSF4 CPSF1 CPSF3 CPSF2 CSTF2T PABPN1 CLP1 CSTF3 CSTF2 CSTF1 SYMPK FIP1L1 PCF11 EIF4A3 CASC3 WDR33 MAGOH NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B NUDT21 SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 CPSF7 SRSF6 SLU7 PAPOLA SRSF7 SRSF9 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME%R-HSA-9665250.1 Resistance of ERBB2 KD mutants to AEE788 CDC37 HSP90AA1 ERBB2 ERBIN ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 80%9032845 Activated NTRK2 signals through CDK5 BDNF NTRK2 CDK5R1 RAC1 TIAM1 CDK5 KANDUTSCH-RUSSELL PATHWAY%REACTOME%R-HSA-6807062.1 Kandutsch-Russell pathway DHCR24 EBP DHCR7 SC5D DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 80%5688849 Defective CSF2RB causes SMDP5 SFTA3 CSF2RB SFTPB CSF2RA SFTPC SFTPD SFTPA2 SFTPA1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.3 Androgen biosynthesis SRD5A2 SRD5A1 HSD3B2 HSD17B3 CGA HSD3B1 CYP17A1 POMC SRD5A3 LHB HSD17B12 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.1 sunitinib-resistant FLT3 mutants FLT3 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.2 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 80%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PARVB RSU1 LIMS1 PXN TESK1 ARHGEF6 ACTN1 PARVA RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 80%8952158 RUNX3 regulates BCL2L11 (BIM) transcription SMAD4 SMAD3 FOXO3 RUNX3 BCL2L11 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.1 Suppression of autophagy RAB7A DUSP16 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.11 Infectious disease NUP62 NUP214 NDC1 SEC13 NUP210 HSPA1A NUP133 PARP1 PYCARD NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 GTF2B GTF2E1 GTF2E2 XRCC4 RNMT NUP155 RNGTT NUP153 CTNND1 PML IMPDH1 CBLL1 IMPDH2 NUP35 NUP37 B2M IL17RC HBEGF IL17RA NCBP1 NCBP2 ELMO1 AHCYL1 TRIM27 EZH2 PRKX MBD3 SUZ12 GATAD2B GATAD2A LIG1 S1PR1 KPNA2 CHD4 CHD3 EED MTA1 MTA2 MTA3 REST STAT1 CCNK ARF1 JAK1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 TYK2 GTF2H5 PATJ VPS39 ERCC3 VPS18 LARP1 ELL VPS11 ERCC2 VPS16 SRPK2 SRPK1 SFTPD TAF7L NLRP12 PPIA CRB3 VPS33A G3BP1 G3BP2 ELOA PALS1 CNBP VPS41 TAF9B IL1R1 TCEA1 GSDMD CCNT2 YWHAB CCNT1 AKT2 RIPK2 IL18 SUPT16H AKT1 IL1A IL1B NOD1 NOD2 RPS6 FKBP1A ELOA2 CALR CDK9 IL6R TAF4B TGFB1 ITGB1 NCKAP1 CYFIP1 SFPQ BRK1 TAF9 TAF1L TAF15 TAF12 TAF13 TAF10 TXNRD1 TAF11 SSRP1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CYBA VAV2 RAB7A NOXO1 SYT1 NCKAP1L WASF1 WASF2 LIG4 CAV1 BAIAP2 ABI2 ENTPD1 ABI1 NOXA1 NOX1 ENTPD5 SH3GL3 LTF FKBP4 PTGES3 DDX5 MYO10 GTF2A1 GTF2A2 STX1B STX1A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 SH3GL2 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A EEF2 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 FEN1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PTGIR FGR BANF1 HMGA1 PSIP1 PACS1 ELOB RANBP1 ELOC EPS15 ITPR1 ITPR2 ITPR3 NOS2 SH3GL1 MAPK14 P2RX7 P2RX4 PTPN6 IRAK1 RCC1 IAPP RAN KPNB1 SYT2 KDM1A PHF21A PDCD6IP CEBPD ABL1 RAB5A RCOR1 ARID4A COMT CYSLTR1 FNTA FNTB SIGMAR1 ATP1B3 ATP1B2 ATP1B1 BRMS1 ATP1A4 HMG20B ATP1A3 ATP1A2 ATP1A1 H3C8 BRD4 CRBN FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 NFE2L2 DOCK2 DOCK1 HDAC2 H3C15 SH3KBP1 VPS45 CTNNB1 VPS33B CORO1A HGS KPNA1 CXCR4 CLTC CLTA ZDHHC8 SAR1B IRAK2 IL10 IL6 CD163 PLK2 RHBDF2 MYH9 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 NMT1 CYSLTR2 GNAT3 PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 TJP1 CALCB CALCRL GIPR LHB GPR83 GPR84 CRHR1 CRHR2 GHRHR MC2R CALCR CGA GPR15 MC1R RLN2 RLN3 GPR27 GLP1R GPR25 GPR20 ADM PTH1R MC4R FZD7 INSL3 TSHB GPR39 GPR32 FSHB GLP2R AVPR2 GPBAR1 PTH2R SV2C GIP SV2B MC3R SV2A VAMP1 ST6GALNAC2 ADORA2A ADORA2B RPN2 FSHR TUSC3 CRH ZDHHC20 PRKCSH PTGER4 RPN1 NPSR1 ZDHHC5 RAMP2 RAMP3 MAGT1 GPR45 ZDHHC2 ZDHHC3 PTH GANAB PTGER2 GNAI3 FUT8 PTH2 MAN2A1 MGAT5 PTHLH GNAI1 ST3GAL4 GNAI2 MGAT1 MGAT2 NPS ST3GAL1 GPR150 GPHA2 GOLGA7 P2RY11 ST3GAL2 SCTR ST3GAL3 ST6GAL1 GCG EDEM2 TSHR MOGS POMC ZDHHC11 GHRH DDOST ADM2 MC5R HNRNPK MGAT4C ZDHHC9 DAD1 VIP MGAT4A CANX RAMP1 GPHB5 MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 KEAP1 ZCRB1 NEDD4L RNF213 GUCY2C SRC PDZD3 CD9 CPSF4 CALM1 AVP SLC25A5 SLC25A4 SLC25A6 PABPN1 ROCK1 CUL5 GSK3A DPEP2 AKT3 DPEP1 DPEP3 ZBP1 MAP2K4 PLCG2 MAP2K7 JUN VAV3 SYK YWHAE MAPK8 BTRC PRKACA TLR1 YWHAG TLR2 SKP1 HSP90AA1 TUBB CASP1 NR3C1 CYFIP2 DYNLL1 WIPF1 WIPF2 WIPF3 UBA52 GJA1 DYNC1I2 DYNC1LI1 DYNC1LI2 UBB PRKAR2B UBC RPS27A DYNC1H1 SFN WNT5A ARPC1B ARPC1A PTPN11 RBX1 DYNLL2 JAK2 IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 C3AR1 PSMD1 IKBKG MAP3K7 CHUK TXNIP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 EIF2AK2 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 JAK3 CHMP1A PSMA7 CBX1 RELA PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 DUSP16 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TBK1 STING1 NCOR2 DVL1 HDAC3 NCOR1 DVL2 TBL1XR1 DVL3 HDAC1 ARPC4 GPS2 ARPC5 TBL1X ARPC2 ARPC3 CBL EGFR SNAP25 PLCG1 NCK1 ACTR3 ACTR2 CDH1 MBL2 RANGAP1 ITGA4 PIK3C3 ROCK2 HSPG2 BECN1 ADAM17 WASF3 MYO1C PDCD1 BTK PIK3R4 CTSL TRIM28 CTSG STAM PTK2 WASL MYO5A XPO1 FURIN WAS H2AC19 DYNC1I1 H2AC14 MYO9B H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ACTG1 RBBP4 RBBP7 H2BC9 NPM1 H4C9 H2BC8 ELMO2 STAM2 H2BC5 H2BC3 H2BC1 H2AC20 NCKIPSD SUGT1 IGHV3-23 AP1S2 IGLV AP1S1 AP1S3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 ATG14 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 HMOX1 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 H2AW V2-19 IGKV1D-33 H2AC17 H2AC12 YWHAQ IGKV2D-28 H2AC1 H2BC18 IGKV4-1 IGHV7-81 H2AC21 UBE2V1 YWHAH V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 YWHAZ IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGKV1D-16 IGHG2 IGLV7-43 IGKV1D-12 MAP1LC3B IGLV1-51 IGLV2-23 UBE2N VHL TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IFNAR1 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 AP1M2 V1-9 V5-4 AP1M1 V1-7 V5-1 V1-5 PDPK1 V1-3 IGKV3D-20 V5-6 TRAF6 IGLV3-19 PSTPIP1 AP1G1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRK IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAP2K1 PRKACG PRKACB YES1 ADCY9 PRKAR1B PRKAR1A ADRB1 PRKAR2A ADRB2 HTR4 TAAR3P HTR6 GNAS HLA-H GSK3B HLA-B HTR7 AP1B1 HLA-C HLA-A HRH2 HLA-F DRD1 HLA-G HLA-E DRD5 TAAR8 ADCY4 TAAR9 ADCY3 TAAR6 ADCY2 ADCY1 ADCY8 TAAR5 ADCY7 ADCY6 TAAR2 ADCY5 CSNK1A1 TAAR1 CREBBP HCK ADRB3 TLR9 TLR8 TLR7 GTF2F1 GTF2F2 CUL3 NLRP3 CD4 C3 GEMIN2 SNRPD2 SNRPD1 SNRPD3 GEMIN4 UBE2I MYH2 SNRPG SUMO1 GEMIN5 GEMIN6 SNRPE GEMIN7 SNRPF IFNA5 GEMIN8 IFNA4 SNRPB DDX20 UVRAG IFNA7 SMN2 IFNA6 HSP90AB1 CCNH IFNA2 ARID4B IFNA8 IFIH1 TRIM4 TBP SAP30 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 SIKE1 IRF3 SAP30L TRAF3 SAP18 IRF7 SUDS3 IFNA10 CDK7 MNAT1 GALNT1 RNF135 TKFC RIPK1 IFNA21 TSG101 VPS4B IFNB1 ISG15 VPS4A MVB12B VAMP2 NFKB2 GGT1 MVB12A VPS36 VTA1 MAVS VPS37C VPS37D VPS37A SNF8 RB1 VPS37B CHMP2B CHMP4C CHMP2A STAT2 CHMP4B CHMP3 UBAP1 CHMP4A CHMP6 CHMP7 GGT5 VPS25 KPNA7 VPS28 KPNA4 CHMP5 KPNA5 KPNA3 IPO5 DAXX GRSF1 DNAJC3 FCGR3A MAPK1 SEC23A PGK1 MAPK3 ENO1 FCGR1A SEC24B SEC24A FCGR2A SEC24D SEC24C TUFM CDC42 LCK CD28 FYN RAC1 PAK2 VAV1 XRCC6 VCP XRCC5 SDC4 SDC2 SDC3 GPC1 GPC3 SDC1 GPC2 CD3G GPC5 GPC4 AGRN GPC6 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CCR5 MET ACTB IL17F IL17A GNG10 TMPRSS2 ACE2 MASP1 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 PRMT1 GNGT2 GNG3 ELK1 CREB1 GNG2 GNG5 GNG4 MEFV PARP10 PARP6 GNG7 PARP4 GNG8 PARP16 PARP9 PARP14 PARP8 CD8B AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 MRC1 NMT2 IFNGR1 NUP107 MAP2K2 NUP188 IFNGR2 NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 80%205017 NFG and proNGF binds to p75NTR NGFR NGF SORCS3 ACTIVATION OF RAS IN B CELLS%REACTOME%R-HSA-1169092.2 Activation of RAS in B cells RASGRP3 HRAS RASGRP1 NRAS TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.2 Transport of the SLBP Dependant Mature mRNA NUP62 NUP214 NDC1 NXF1 SEC13 NUP210 NUP133 ALYREF NUP93 SLBP NUP50 NUP54 NUP205 EIF4E POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 NCBP1 RANBP2 NCBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 80%9664433 Leishmania parasite growth and survival IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 CALM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 AVP IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGHG3 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB YES1 ADCY9 PRKAR1B PRKAR1A ADRB1 PRKAR2A ADRB2 HTR4 TAAR3P HTR6 GNAS HTR7 HRH2 PTGIR DRD1 AHCYL1 DRD5 FGR TAAR8 ADCY4 TAAR9 ADCY3 TAAR6 ADCY2 ADCY1 ADCY8 TAAR5 ADCY7 ADCY6 TAAR2 ADCY5 ITPR1 ITPR2 DPEP2 ITPR3 TAAR1 DPEP1 DPEP3 HCK ADRB3 PRKX MAPK14 PLCG2 SYK IAPP PRKACA PRKAR2B CYSLTR1 GGT1 GGT5 FCGR3A FCGR1A FCGR2A FYN PLCG1 CD3G IL10 IL6 CD163 PLK2 ADAM17 RHBDF2 MYH9 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB GPR83 GPR84 CRHR1 CRHR2 GHRHR MC2R CALCR CGA GNG10 GPR15 MC1R RLN2 RLN3 GNG12 GPR27 GNG11 GLP1R GNG13 GPR25 GPR20 ADM GNB2 PTH1R FURIN MC4R GNB1 GNB4 GNB3 INSL3 TSHB GPR39 GPR32 GNB5 FSHB GLP2R GNGT1 AVPR2 GPBAR1 GNGT2 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 P2RY11 GNG3 SCTR GCG CREB1 GNG2 GNG5 TSHR GNG4 POMC GHRH ADM2 GNG7 MC5R GNG8 VIP RAMP1 GPHB5 IGHV3-23 IGLV IGLV2-8 IGKV1-16 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.1 Defective Intrinsic Pathway for Apoptosis YWHAE GOLGA2 CAPN2 CDK5R1 CDC25B CAPN1 PRDX2 CAST PRDX1 SOD2 BCL2L11 CDC25A LMNB1 CDC25C CDKN2A FASLG FOXO3 JUN CAPNS1 TP53 APP C1QBP CDK5 CAPNS2 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 80%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 NGF PROCESSING%REACTOME DATABASE ID RELEASE 80%167060 NGF processing FURIN NGF PCSK6 PCSK5 SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.3 Signaling by LRP5 mutants KREMEN1 KREMEN2 LRP5 DKK1 DKK2 DKK4 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME DATABASE ID RELEASE 80%5579010 Defective CYP24A1 causes HCAI CYP24A1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.2 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR3GL TBP POLR1C POLR1D POLR2E POLR3A POLR2F POLR3B POLR3C POLR2H POLR3D POLR3E SNAPC5 SNAPC1 POLR2K POLR3F SNAPC2 POLR2L POLR3G SNAPC3 POLR3H SNAPC4 POLR3K ZNF143 BRF2 BDP1 POU2F1 CRCP POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 80%9615933 Postmitotic nuclear pore complex (NPC) reformation RANGAP1 NUP85 NUP62 NDC1 SEC13 RCC1 NUP43 RAN KPNB1 NUP133 TNPO1 NUP155 NUP93 UBE2I SUMO1 NUP54 NUP205 POM121 AHCTF1 NUP107 NUP188 NUP35 NUP37 NUP160 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 80%432720 Lysosome Vesicle Biogenesis AP1M2 AP1M1 CLTC SH3GL2 CLTA AP4E1 AP4M1 TXNDC5 AP1G2 AP1G1 DNAJC6 DNASE2 ARF1 BLOC1S1 CLVS2 AP4S1 CLVS1 CTSZ M6PR GNS AP4B1 HGS HSPA8 VAMP7 DNM2 VAMP2 ARRB1 AP1B1 AP1S2 CLTB AP1S1 CHMP2A APP AP1S3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.3 Mitochondrial protein import CS COQ2 ACO2 HSCB TIMM17A TIMM17B COA6 TIMM23 TIMM22 TIMM21 SLC25A12 COX19 FXN SLC25A13 NDUFB8 TOMM40 TIMM9 TIMM13 TIMM10 ATP5F1A SLC25A4 HSPD1 ATP5F1B TIMM8B PMPCB SLC25A6 PMPCA TIMM8A MTX2 IDH3G GFER TOMM7 TOMM5 TOMM6 OTC SAMM50 MTX1 TOMM70 VDAC1 TOMM20 TOMM22 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 HSPA9 CMC4 CMC2 PAM16 BCS1L COX17 TIMM50 ATP5MC1 PITRM1 GRPEL1 LDHD GRPEL2 CYC1 DNAJC19 TAFAZZIN COA4 CHCHD10 TIMM44 TIMM10B ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 80%9662851 Anti-inflammatory response favouring Leishmania parasite infection IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 CALM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 AVP IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGHG3 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB YES1 ADCY9 PRKAR1B PRKAR1A ADRB1 PRKAR2A ADRB2 HTR4 TAAR3P HTR6 GNAS HTR7 HRH2 PTGIR DRD1 AHCYL1 DRD5 FGR TAAR8 ADCY4 TAAR9 ADCY3 TAAR6 ADCY2 ADCY1 ADCY8 TAAR5 ADCY7 ADCY6 TAAR2 ADCY5 ITPR1 ITPR2 DPEP2 ITPR3 TAAR1 DPEP1 DPEP3 HCK ADRB3 PRKX MAPK14 PLCG2 SYK IAPP PRKACA PRKAR2B CYSLTR1 GGT1 GGT5 FCGR3A FCGR1A FCGR2A FYN PLCG1 CD3G IL10 IL6 CD163 PLK2 ADAM17 RHBDF2 MYH9 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB GPR83 GPR84 CRHR1 CRHR2 GHRHR MC2R CALCR CGA GNG10 GPR15 MC1R RLN2 RLN3 GNG12 GPR27 GNG11 GLP1R GNG13 GPR25 GPR20 ADM GNB2 PTH1R FURIN MC4R GNB1 GNB4 GNB3 INSL3 TSHB GPR39 GPR32 GNB5 FSHB GLP2R GNGT1 AVPR2 GPBAR1 GNGT2 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 P2RY11 GNG3 SCTR GCG CREB1 GNG2 GNG5 TSHR GNG4 POMC GHRH ADM2 GNG7 MC5R GNG8 VIP RAMP1 GPHB5 IGHV3-23 IGLV IGLV2-8 IGKV1-16 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.2 Defective TPMT causes TPMT deficiency TPMT ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 80%174577 Activation of C3 and C5 CFB C4A C4B_2 C3 C2 C5 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-HSA-913709.3 O-linked glycosylation of mucins GALNT12 C1GALT1C1 C1GALT1 GALNT3 B3GNT7 B3GNT4 B3GNT3 B3GNT2 B4GALT6 B4GALT5 MUC12 MUC15 MUC13 MUCL1 MUC1 ST6GALNAC2 MUC2 MUC7 MUC4 MUC6 GALNT2 ST3GAL4 MUC3A MUC3B ST3GAL1 ST3GAL2 GALNT11 ST3GAL3 GALNT14 ST6GAL1 GALNT13 GALNT16 GALNT15 MUC16 GALNT18 MUC17 GALNT17 GALNT10 MUC19 GALNTL5 GALNTL6 MUC20 B3GNTL1 GALNT1 MUC21 GALNT9 ST6GALNAC3 GALNT8 MUC5AC ST6GALNAC4 B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 MUC5B GALNT5 GALNT4 A4GNT APOPTOSIS%REACTOME DATABASE ID RELEASE 80%109581 Apoptosis PSMD8 PSMD9 FAS PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 TICAM2 GSDMD YWHAB PSMA5 LMNB1 PSMA6 YWHAQ PSMA3 PSMA4 TFDP1 PSMA1 PRKCQ PSMA2 AKT2 PSME3 YWHAH TFDP2 PSME4 PSME1 AKT1 PSME2 PSMD10 PSMB11 GSN PSMD12 PSMD11 PSMD14 PSMD13 YWHAZ BAX PSMA7 BID ARHGAP10 PMAIP1 PSMB10 MAPK1 PSMA8 PSMB6 MAPK3 CTNNB1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 UACA PSMB1 PSMF1 KPNA1 PSMB8 PSMB9 CYCS SEM1 CDKN2A PSMC5 PSMC6 PSMC3 PSMC4 PPP1R13B PSMC1 PSMC2 ROCK1 VIM DSP UNC5A UNC5B BCL2L1 PAK2 DSG1 CASP7 DIABLO CDH1 DSG2 DCC DBNL DAPK1 DAPK2 DAPK3 OMA1 BAD PKP1 H1-1 CASP9 H1-0 AKT3 H1-3 H1-2 H1-5 H1-4 OCLN NMT1 PPP3CC APPL1 CASP3 DFFB DFFA XIAP GAS2 MAPT SATB1 PTK2 CARD8 TJP1 BMF CLSPN BMX STK24 TP53 STK26 AVEN HMGB2 APIP YWHAE OPA1 MAPK8 DNM1L PLEC ADD1 SPTAN1 ACIN1 KPNB1 LY96 DSG3 CD14 YWHAG TLR4 APC APAF1 CASP6 C1QBP TP63 TP73 DYNLL1 HMGB1 BCAP31 CASP8 UBA52 BAK1 GZMB PRKCD TICAM1 TRAF2 BCL2 UBB PPP3R1 UBC TNFSF10 RPS27A TP53BP2 STAT3 MAGED1 BCL2L11 RIPK1 GSDME SFN FADD FNTA TNFRSF10B TNFRSF10A BBC3 TRADD FASLG BIRC2 DYNLL2 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 80%163615 PKA activation PRKACG ADCY3 PRKACB ADCY2 ADCY1 ADCY8 ADCY7 ADCY9 ADCY6 ADCY5 PRKAR1B PRKAR1A NBEA PRKAR2A PRKACA PRKAR2B CALM1 ADCY4 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.3 Diseases associated with visual transduction RBP4 NAPEPLD OPN1LW RDH5 RBP1 OPN1SW OPN1MW RDH12 LRAT STRA6 TTR ABCA4 RLBP1 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 80%176412 Phosphorylation of the APC C ANAPC11 CDC23 CDC26 CDC27 PLK1 ANAPC7 UBE2C UBE2E1 CDK1 UBE2S CDC16 CCNB1 ANAPC4 ANAPC5 ANAPC15 UBE2D1 ANAPC1 ANAPC2 ANAPC16 ANAPC10 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%209968 Thyroxine biosynthesis DIO3 DUOX1 TPO IYD DUOX2 SLC5A5 CGA TSHB DIO1 DIO2 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 80%9018682 Biosynthesis of maresins CYP2D6 CYP2E1 CYP2C9 CYP2C8 EPHX2 CYP3A4 ALOX5 CYP1A2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%190241 FGFR2 ligand binding and activation FGF22 FGF10 FGF16 FGF7 FGF18 FGFBP3 FGFBP1 FGFBP2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 80%420092 Glucagon-type ligand receptors GNGT2 GIP VIPR1 VIPR2 SCT CYSLTR2 ADCYAP1 GNG3 ADCYAP1R1 SCTR GNG2 GCG GNG5 GIPR GNG4 GHRH GNG7 GNG8 GHRHR VIP GNG10 GNG12 GLP1R GNG11 GNG13 GNB2 GNAS GNB1 GNB4 GNB3 GNB5 GLP2R GNGT1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME DATABASE ID RELEASE 80%193634 Axonal growth inhibition (RHOA activation) NGFR ARHGDIA OMG RHOA MAG RTN4 MCF2 LINGO1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME DATABASE ID RELEASE 80%5619042 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 80%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PFKFB1 PPP2R1B PPP2R1A PPP2R5D MLXIPL REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME%R-HSA-381426.2 Regulation of IGF Activity by IGFBP CP LTBP1 DNAJC3 AHSG FUCA2 IGFBP3 CSF1 MEN1 MSLN PCSK9 HSP90B1 CKAP4 KTN1 SDC2 BPIFB2 IGF1 GZMH VCAN GPC3 QSOX1 ADAM10 IL6 MELTF KLK2 APOE APOB MBTPS1 APOA2 APOA1 C4A APOA5 LAMC1 ALB P4HB KLK3 CST3 CTSG TIMP1 CDH2 MMP1 MMP2 PNPLA2 C3 PLG SERPINC1 IGF2 SPP1 TNC KNG1 PAPPA2 LAMB1 DMP1 IGFALS LGALS1 APP EVA1A CCN1 CHGB IGFBP1 IGFBP2 IGFBP5 IGFBP6 FGA IGFBP4 PAPPA APLP2 KLK1 SHISA5 SERPIND1 PDIA6 MXRA8 SPARCL1 PRKCSH SCG3 SCG2 FGG TGOLN2 STC2 F2 PENK IGFBP7 AMELX F5 WFS1 AMBN TMEM132A BMP4 TF PROC CALU HRC FBN1 SERPINA10 MIA3 CHRDL1 PRSS23 BMP15 ANO8 MEPE FGF23 RCN1 VGF ENAM MGAT4A AMTN VWA1 FAM20C FAM20A MFGE8 GAS6 MATN3 ITIH2 AFP FSTL1 FSTL3 SPP2 SERPINA1 APOL1 LAMB2 GOLM1 NUCB1 NOTUM KLK13 FN1 INOSITOL TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%429593 Inositol transporters SLC5A3 SLC5A11 SLC2A13 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.2 Syndecan interactions CASK THBS1 PRKCA VTN ITGAV TRAPPC4 ITGB4 ITGB3 ITGA6 TGFB1 ITGA2 ITGB5 ITGB1 SDC4 SDC2 SDC3 FGF2 TNC ACTN1 SDC1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.5 Toll Like Receptor 7 8 (TLR7 8) Cascade IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 TICAM2 CHUK TLR9 MAPKAPK3 TLR8 MAPKAPK2 TLR7 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A LY96 CD14 DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N TLR4 MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 TICAM1 CUL1 ELK1 CREB1 UBB MAP2K1 IRF7 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER S100A12 ECSIT MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 80%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CDK6 CCND3 CCND2 CCND1 CDK4 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.3 Adenylate cyclase inhibitory pathway ADCY3 ADCY2 GNAL ADCY1 ADCY8 ADCY7 ADCY9 ADCY6 ADCY5 GNAI3 GNAT3 GNAI1 GNAI2 ADCY4 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.2 Activation of ATR in response to replication stress CDC7 MCM10 DBF4 RAD1 ORC5 ORC4 RFC5 ORC6 RFC3 HUS1 CDK2 ORC1 CLSPN RFC4 ORC3 ORC2 RFC2 RPA2 CDC6 RPA3 ATRIP RAD17 CHEK1 ATR CDC25A CDC25C RAD9B RAD9A RPA1 CDC45 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.2 Bicarbonate transporters AHCYL2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A8 SLC4A5 SLC4A9 SLC4A7 SLC4A10 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.1 Loss of MECP2 binding ability to the NCoR SMRT complex NCOR1 TBL1XR1 GPS2 TBL1X NCOR2 HDAC3 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 80%191859 snRNP Assembly NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 GEMIN2 PHAX SNRPD2 SNRPD1 NUP155 SNRPD3 PRMT5 WDR77 CLNS1A GEMIN4 SNRPG NUP153 GEMIN5 GEMIN6 SNRPE GEMIN7 SNRPF GEMIN8 NUP35 SNRPB NUP37 DDX20 TGS1 SMN2 SNUPN NCBP1 NCBP2 NUP107 NUP188 SYNTHESIS OF PS%REACTOME%R-HSA-1483101.2 Synthesis of PS PTDSS2 PTDSS1 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 80%111452 Activation and oligomerization of BAK protein BID BAK1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.3 SUMOylation of SUMOylation proteins SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 TOPORS NUP43 RAE1 RANBP2 NUP155 UBE2I NUP153 SUMO1 NUP107 NUP188 NUP35 NUP37 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.3 Transport of Ribonucleoproteins into the Host Nucleus NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 KPNB1 RANBP2 KPNA1 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 80%434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion PLCB3 GNAQ GNA14 PLCB1 PLCB2 GNA15 GNA11 FFAR1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.1 Caspase-mediated cleavage of cytoskeletal proteins CASP3 PLEC CASP7 DBNL GAS2 ADD1 MAPT SPTAN1 CASP8 GSN CASP6 VIM PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 80%211945 Phase I - Functionalization of compounds AOC1 CYP26C1 CYP2C9 CYP2C8 ALDH2 ADH1A CYP19A1 CYP3A4 CMBL ALDH3A1 PTGS1 MAOB MTARC2 MTARC1 CYP1B1 EPHX1 BPHL CBR3 CYB5B AOC3 NQO2 AOC2 AADAC RXRA ARNT CYP1A2 MAOA CES3 CYP11A1 FMO1 FDX1 FMO2 FDX2 FMO3 FDXR CYP11B2 CYP21A2 AHR ARNT2 AHRR CYP4V2 CYP4A22 CYP4A11 CYP3A43 CYP2A7 CYP2U1 CYP11B1 CYP2A6 POR CYP3A5 CYP2C18 CYP3A7 CYP2B6 CYP2A13 CYP2F1 CYP4F22 CYP4F12 CYP2W1 CYP2J2 CYP2S1 CYP4F2 PAOX CYP4F3 CYP4B1 CYP4F8 CYP4F11 TBXAS1 CYP1A1 ADH4 ACSS2 ALDH1B1 ADH1C NCOA2 ADH1B ALDH1A1 ACSS1 ADH7 ADH5 ADH6 PTGES3 CYP46A1 CYP39A1 HSP90AB1 PTGIS CYP8B1 POMC CYP51A1 CYB5R3 NR1H4 CYP7B1 AIP CYP7A1 CYP27A1 CYP27B1 NCOA1 CYP26A1 CYP26B1 CYP24A1 CYP2R1 CYP2D6 CYP2E1 CES2 CES1 CYP2C19 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 80%4839726 Chromatin organization KDM5A KDM5B PHF2 KDM5C KDM5D KDM3B PHF8 UTY KDM6B KDM2A KDM4D KDM2B H2AW ARID5B HDAC10 JMJD6 H2AC17 RIOX2 H2AC12 H2AC1 H2BC18 HDAC8 H2AC21 KAT8 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 KAT14 TADA2A ZZZ3 SGF29 ING4 ING3 PRMT7 PAX3 SUPT3H TAF6L RPS2 BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 KDM4C ENY2 TAF5L MBIP DMAP1 DR1 COPRS MRGBP YEATS2 TADA1 VPS72 MSL2 MSL3 RUVBL2 MSL1 KANSL1 KANSL2 KANSL3 KMT2E SUV39H2 SETD2 PRDM9 SETD3 SETD6 DOT1L KMT2B SETD7 DPY30 NSD3 NSD1 NSD2 PRDM16 KMT5B SMYD3 ATF7IP SETDB1 KMT5C SETD1B SETDB2 SETD1A ASH1L AEBP2 ATF2 ASH2L EP400 CREBBP EZH2 MECOM KAT2B KAT2A EP300 MBD3 SUZ12 GATAD2B GATAD2A KDM3A KDM1B BRWD1 CHD4 CHD3 PRMT5 EED WDR77 KAT5 KDM1A MTA1 MTA2 MTA3 REST WDR5 ACTL6A SUV39H1 DNMT3A ARID4B SAP130 CLOCK MCRS1 SMARCD1 PHF21A SMARCD2 SMARCB1 SAP30 ARID2 SMARCD3 SMARCE1 SMARCC1 PBRM1 SMARCC2 OGT EHMT1 ACTL6B RBBP5 ARID1A SMARCA2 PADI2 ARID1B SAP30L SAP18 SUDS3 MEAF6 RCOR1 ARID4A NFKB2 ING5 BRMS1 EHMT2 HMG20B H3C8 BRD1 JAK2 CCND1 HDAC2 H3C15 KMT5A CDK4 KAT6A RELA SMYD2 BRPF1 BRPF3 NFKB1 PHF20 KDM7A KMT2A NCOR2 HDAC3 NCOR1 TBL1XR1 TAF9 HDAC1 KDM4A ATXN7 GPS2 TBL1X TAF12 TAF10 TRRAP TADA2B KDM6A TADA3 YEATS4 KMT2D KMT2C ACTB PRMT6 EPC1 NCOA2 USP22 HCFC1 PRMT1 KDM4B H2AX H2AB1 H2AC19 H2AC14 H2BC21 RUVBL1 H2BU1 H2AC8 CARM1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RBBP4 RBBP7 H2AZ1 H2BC9 SMARCA4 H2AZ2 PRMT3 H4C9 H2BC8 H2BC5 NCOA1 H2BC3 H2BC1 H2AC20 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 80%110381 Resolution of AP sites via the single-nucleotide replacement pathway LIG3 POLB APEX1 XRCC1 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 80%5602410 TLR3 deficiency - HSE TLR3 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 80%9010553 Regulation of expression of SLITs and ROBOs RPS11 PSMD8 RPS10 PSMD9 RPL39 PSMD6 RPS13 PSMD7 RPS12 PSMD4 RPS9 PSMD5 RPL21 PSMD2 RPS7 PSMD3 RPS8 PSMD1 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A PSMA5 RPL9P9 PSMA6 PSMA3 ROBO2 PSMA4 PSMA1 PSMA2 PSME3 RPL37A PSME4 RPL24 PSME1 RPL27 PSME2 RPL26 ROBO1 RPL29 RPL28 PSMD10 RPS4Y2 PSMB11 PSMD12 PSMD11 RPL10 PSMD14 RPL12 RPS6 PSMD13 RPL11 RPL36A RPS27L PSMA7 RPS4Y1 RPS15A PSMB10 RPL14 PSMA8 RPS3 PSMB6 RPL13 PSMB7 RPS2 LDB1 PSMB4 RPL15 PSMB5 RPL18 PSMB2 RPL17 PSMB3 RPL19 RPL39L PSMB1 PSMF1 RPL41 RPL35A RPL23A PSMB8 PSMB9 RPL3L SEM1 RPS26 EIF4G1 RPS25 PSMC5 RPS28 PSMC6 RPS27 PSMC3 RPS29 PSMC4 RPL27A PSMC1 PSMC2 RPL22L1 RPS20 FAU RPS21 SLIT1 RPL26L1 RPS24 RPS23 SLIT2 ISL1 HOXA2 COL4A5 UPF2 EIF4A3 CASC3 MAGOH USP33 NCBP1 NCBP2 UPF3A ZSWIM8 MSI1 RBM8A ELOB ELOC UPF3B MAGOHB RNPS1 ETF1 CUL2 LHX3 LHX2 LHX4 LHX9 UBA52 GSPT2 GSPT1 UBB UBC RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 DAG1 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RBX1 RPL35 RPLP2 RPL38 RPL37 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.2 FGFR2 alternative splicing TIAL1 PTBP1 RBFOX2 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D HNRNPH1 ESRP2 POLR2E ESRP1 POLR2F POLR2G POLR2H POLR2I HNRNPA1 POLR2J POLR2K TIA1 POLR2L HNRNPM HNRNPF NCBP1 NCBP2 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 80%8875656 MET receptor recycling CRK RAB4B CRKL ARF6 HGF RAB4A GAB1 MET GGA3 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 80%9669936 Sorafenib-resistant KIT mutants KIT BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 80%9026762 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 80%9026403 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 80%112303 Electric Transmission Across Gap Junctions GJD2 GJC1 GJA10 PANX1 PANX2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%R-HSA-3296482.3 Defects in vitamin and cofactor metabolism MCCC1 MMUT MMACHC MMADHC CBLIF PC CUBN BTD AMN PCCA TCN2 HLCS CD320 ABCD4 PCCB ACACA MTRR MCCC2 MMAA LMBRD1 MMAB MTR METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 80%6806664 Metabolism of vitamin K VKORC1 VKORC1L1 UBIAD1 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME%R-HSA-209952.1 Peptide hormone biosynthesis PCSK1 INHBB CGA INHBA TSHB INHA CGB8 INHBC POMC FSHB INHBE LHB TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.2 Toxicity of botulinum toxin type B (botB) VAMP2 SYT2 SYT1 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME DATABASE ID RELEASE 80%3560792 Defective SLC26A2 causes chondrodysplasias SLC26A2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 80%430116 GP1b-IX-V activation signalling GP9 FLNA VWF RAF1 GP1BB GP1BA PIK3R1 YWHAZ GP5 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.3 Intraflagellar transport DYNLL1 DYNC2I2 DYNC2I1 TRAF3IP1 WDR19 IFT80 IFT81 DYNC2LI1 TRIP11 HSPB11 DYNLT2B TTC30B TTC30A KIF3B IFT20 IFT22 IFT27 KIF3C DYNLRB2 DYNLRB1 TTC26 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 IFT172 KIF17 DYNC2H1 IFT88 KIF3A TTC21B TNPO1 IFT122 IFT52 IFT57 IFT140 WDR35 KIFAP3 DYNLL2 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 80%9634597 GPER1 signaling ADCY3 GNGT2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SRC GNAI3 GNAT3 GNAI1 GNAI2 GNAZ GNG3 GNG2 GNG5 GNG4 PRKAR2B GNG7 GNG8 PRKACG PRKACB ADCY9 PRKAR1B GNG10 PRKAR1A ITGA5 PRKAR2A GNG12 PRKACA GNG11 GNG13 GNB2 GNAS GNB1 ITGB1 GPER1 GNB4 GNB3 GNB5 GNGT1 ADCY4 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.6 Transmission across Chemical Synapses CAMK2B GRIA1 GRIA2 CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2C GRIN2B GRIN1 NRGN GRIN2D GRIN2A DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G RAB3A SLC5A7 PLCB3 CHAT PLCB1 PLCB2 MAOA PDPK1 DNAJC5 ACHE PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PRKAR2A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 BCHE PRKX CAMKK1 CAMKK2 GABRB3 GABRB2 GABRB1 GABRR3 GABRR2 GABRR1 KPNA2 GNAL NPTN GABRG3 GABRG2 CACNB1 GABRA2 CACNB2 GABRQ CACNB3 GABRA1 CACNB4 GABRA6 SLC22A2 GABRA5 SLC38A1 SLC22A1 GABRA4 GABRA3 NBEA ABAT SLC6A13 ARL6IP5 SLC6A12 PRKACA SLC6A11 CACNA2D1 SLC1A1 CACNA2D3 SLC6A1 SLC1A2 SLC1A3 SLC6A3 SLC1A6 SLC1A7 SLC18A2 SLC38A2 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 SLC32A1 ALDH5A1 GLRA1 GLRA2 GLRA3 NAAA CHRNA7 CACNA1B CACNA1A CACNA1E CACNG8 CACNA2D2 HTR3E GLS HTR3C HTR3D CACNG2 HTR3A CACNG3 SLC17A7 HTR3B CACNG4 PRKAR2B NCALD RPS6KA6 MYO6 GLRB COMT VAMP2 RPS6KA3 RPS6KA2 NSF RPS6KA1 PRKCG PRKCA GRIP2 GRIP1 TSPAN7 PICK1 GRIA3 GRIA4 PRKAA1 PRKAA2 PRKCB PRKAG1 ALDH2 PRKAG2 TOMT PRKAG3 SLC6A4 PRKAB2 PRKAB1 EPB41L1 MAPK1 MAPK3 AKAP5 MDM2 CHRNB2 CHRNA1 LIN7B CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNG GLS2 CHRNA4 CHRNE CHRNA6 CAMK4 RAC1 GIT1 NRAS SNAP25 RASGRF2 HRAS GLUL RASGRF1 KIF17 CASK LIN7A LIN7C PPM1E PPM1F GRIN3B KCNJ2 APBA1 KCNJ3 CAMK1 KCNJ4 GABBR2 CHRNA9 KCNJ5 GABBR1 UNC13B KCNJ10 SYT1 KCNJ12 SYN3 KCNJ9 CPLX1 SYN2 SYN1 RIMS1 KCNJ15 GAD1 PPFIA1 KCNJ16 GAD2 PPFIA4 TSPOAP1 PPFIA3 PPFIA2 GNAT3 GNG10 GNG12 GNG11 HSPA8 GNG13 ARHGEF9 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNAI3 STX1A GNAI1 GNAI2 GNG3 CREB1 GNG2 GNG5 GNG4 GNG7 GNG8 AP2A1 SLC18A3 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.1 Mitochondrial translation initiation MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPS21 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 OXA1L MRPL53 MRPS9 MTFMT MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPS33 MRPL18 MRPL19 MRPS34 MRPS31 MRPL16 MRPL17 MTIF2 MRPL58 MTIF3 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111469.3 SMAC, XIAP-regulated apoptotic response CYCS CASP3 XIAP CASP7 DIABLO CASP9 APAF1 G2 PHASE%REACTOME%R-HSA-68911.3 G2 Phase CCNA2 E2F1 CCNA1 CDK2 E2F3 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.2 TYSND1 cleaves peroxisomal proteins PHYH SCP2 ACOX1 HSD17B4 ACAA1 TYSND1 AGPS MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 80%8875555 MET activates RAP1 and RAC1 CRK CRKL RAP1B RAP1A HGF RAC1 GAB1 MET DOCK7 RAPGEF1 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 80%9603505 NTRK3 as a dependence receptor NTRK3 NELFB BAX GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 80%70263 Gluconeogenesis SLC25A10 GPI PCK1 G6PC1 SLC25A12 G6PC3 ALDOC SLC25A13 SLC37A4 ALDOA PGK1 GAPDHS ENO1 SLC25A1 GOT1 PC MDH2 PGAM1 ENO2 ENO3 PGK2 PCK2 GOT2 ALDOB SLC37A1 TPI1 MDH1 PGAM2 G6PC2 GAPDH SLC25A11 FBP1 FBP2 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 80%9632974 LXRs regulate gene expression linked to gluconeogenesis NRIP1 RXRA NR1H3 PCK1 RXRB SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 80%1250347 SHC1 events in ERBB4 signaling NRG1 SOS1 HRAS BTC NRG3 NRG4 SHC1 NRG2 HBEGF EREG NRAS DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 80%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.2 Glucocorticoid biosynthesis SERPINA6 HSD3B2 CYP11B2 CYP21A2 CYP11B1 HSD3B1 HSD11B1 HSD11B2 CYP17A1 POMC GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.3 Golgi Associated Vesicle Biogenesis SH3GL2 AP3B1 HSPA8 RAB5C TFRC AP1M2 AP1M1 FTL AP4E1 CLINT1 TXNDC5 TGOLN2 AP1G1 AP3S1 SH3D19 TPD52 GAK DNAJC6 CPD NAPA BLOC1S4 BLOC1S6 SNX2 ARF1 OCRL BLOC1S1 PICALM BLOC1S3 SNX9 SNX5 TBC1D8B SNAPIN SORT1 DTNBP1 HIP1R IGF2R PUM1 TPD52L1 AP4B1 NECAP1 GOLGB1 YIPF6 ACBD3 VAMP7 FTH1 DNM2 VAMP2 ARRB1 AP1B1 PIK3C2A AP1S2 AP1S1 AP1S3 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 80%5619094 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.1 Defective Mismatch Repair Associated With MSH3 MSH3 MSH2 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 80%975578 Reactions specific to the complex N-glycan synthesis pathway MAN2A1 MAN2A2 FUCA1 MGAT2 CHST10 CHST8 CGA FUT3 LHB FUT8 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.4 Miscellaneous transport and binding events ADD2 CTNS ADD1 LRRC8C LRRC8D TUSC3 LRRC8A LRRC8B ADD3 LRRC8E MAGT1 NIPAL4 NIPAL1 NIPAL2 NIPAL3 AZGP1 NIPA1 ANKH NIPA2 DMTN MRS2 SLC66A1 MMGT1 PIP SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 80%5637812 Signaling by EGFRvIII in Cancer SHC1 EGF GAB1 PIK3R1 CBL EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 80%168799 Clostridium neurotoxicity SNAP25 STX1A SV2C SV2B SV2A VAMP2 VAMP1 SYT2 STX1B SYT1 SIGNALING BY BMP%REACTOME%R-HSA-201451.4 Signaling by BMP AMHR2 AMH ZFYVE16 UBE2D3 GDF2 SMAD9 BMP10 SMAD5 BMPR1B BMPR1A ACVRL1 ACVR2B BMPR2 NOG ACVR2A GREM2 SMAD4 SMAD7 CHRDL1 SMURF2 SMURF1 SMAD1 SMAD6 BMP2 FSTL1 SKI UBE2D1 CER1 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.1 NOTCH3 Activation and Transmission of Signal to the Nucleus YBX1 EGF NOTCH3 TACC3 UBA52 EGFR WWP2 UBB UBC RPS27A APH1A PSENEN APH1B PSEN2 JAG2 ADAM10 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 PSEN1 JAG1 NCSTN INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 80%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH D2HGDH ADHFE1 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 80%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 80%203641 NOSTRIN mediated eNOS trafficking DNM2 NOS3 NOSTRIN CAV1 WASL TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 80%6787450 tRNA modification in the mitochondrion TRMT10C PRORP GTPBP3 HSD17B10 TRIT1 TRMU MTO1 TRMT61B CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.3 Choline catabolism CHDH SARDH ALDH7A1 BHMT SLC44A1 DMGDH PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME%R-HSA-6791465.2 Pentose phosphate pathway disease TALDO1 RPIA APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.2 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway LIG3 PNKP NEIL2 NEIL1 POLB OGG1 XRCC1 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.3 Nephrin family interactions ACTN4 CASK KIRREL3 KIRREL1 IQGAP1 KIRREL2 MAGI2 PIK3CB SPTAN1 PIK3R2 CD2AP NPHS1 FYN PIK3R1 ACTN2 PIK3CA SPTBN1 ACTN3 NCK2 NCK1 WASL ACTN1 EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 80%162594 Early Phase of HIV Life Cycle PSIP1 CD4 CCR5 KPNA1 XRCC4 XRCC6 XRCC5 CXCR4 PPIA LIG1 LIG4 FEN1 BANF1 HMGA1 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%209905 Catecholamine biosynthesis DDC PNMT TH DBH ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.3 Acyl chain remodeling of DAG and TAG DGAT1 AWAT2 DGAT2L6 MGLL PNPLA3 DGAT2 PNPLA2 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME%R-HSA-3656243.1 Defective ST3GAL3 causes MCT12 and EIEE15 ACAN LUM OGN OMD KERA ST3GAL3 PRELP FMOD SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 80%3108232 SUMO E3 ligases SUMOylate target proteins BMI1 HERC2 INCENP SUMO3 SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 HIPK2 NUP210 IKBKG RING1 NUP133 DAXX PARP1 NSMCE3 NSMCE2 NSMCE1 HDAC2 SMC1A PIAS1 NUP93 RNF168 EID3 NSMCE4A NUP50 NUP54 SP100 NUP205 POM121 BLM XPC AAAS NUP160 RNF2 HDAC7 RELA WRN POM121C NUP42 NUP85 RAD21 TDG TPR NUP88 NUP43 RAE1 RANBP2 CBX8 AURKB PHC2 PHC1 XRCC4 NUP155 NFKBIA CBX4 RARA VHL CDKN2A CBX2 MDM2 PCGF2 RPA1 NUP153 PHC3 RXRA PML RAD52 STAG1 STAG2 NUP35 NUP37 NCOR2 CASP8AP2 MBD1 TP53BP1 HDAC1 SIN3A TOP2A TOP1 UHRF2 PPARGC1A NR1H2 RANGAP1 PARK7 DDX17 BIRC5 ZNF131 NR4A2 PPARA THRB NR2C1 TRIM27 CREBBP TOP2B NR3C2 PPARG ESR1 PCNA TRIM28 EP300 SATB1 NOP58 SUZ12 TP53 CETN2 HDAC4 L3MBTL2 SATB2 MITF ZBED1 SAFB FOXL2 PIAS3 HIC1 NCOA2 SP3 TOPORS CHD3 PGR TFAP2B DDX5 TFAP2C UBE2I MTA1 SUMO1 RORA NR3C1 DNMT3A VDR DNMT3B NRIP1 IKBKE MRTFA DNMT1 CBX5 AURKA AR CTBP1 HNRNPK CDCA8 NPM1 H4C9 NCOA1 ZNF350 HNRNPC NFKB2 NR5A1 ING2 MDC1 NUP107 NUP188 SMC5 SMC6 BRCA1 SMC3 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME%R-HSA-4570571.2 Defective RFT1 causes CDG-1n RFT1 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 80%5684996 ERK1 ERK2 pathway CNKSR1 KRAS TLN1 RAF1 NRTN VCL CAMK2B CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2B PRKCQ GRIN1 GRIN2D DLG1 SPTA1 DLG2 DLG3 LRRC7 DLG4 NEFL RASGRP1 CALM1 RASGRP4 CAMK2G CSF2 IL5RA IL3RA BCL2L1 MAPK12 BTC NRG3 NRG4 NRG2 HBEGF EREG MAP2K1 PPP2R5E PRKG2 RET PPP2R5B PPP2R5A PPP2R5C CSF2RB CSF2RA FLT3 KLB SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 IRS2 FGF19 RASA1 PPP1CB RASA2 CUL3 FGFR4 RASAL1 RASAL2 PPP2R1A RASAL3 DAB2IP NF1 KBTBD7 UBA52 ANGPT1 TEK FRS2 FRS3 FGF1 FGF2 FGF3 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 FGF22 FGF10 JAK1 RPS27A IQGAP1 TYK2 FNTA FNTB CDK1 SPTBN4 PTPN11 SPTBN5 RBX1 JAK2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 SPTBN2 PSMD3 PSMD1 YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BRAF JAK3 PSMA7 PPP2CA PPP2CB PSMB10 MAPK1 PSMA8 GFRA1 PSMB6 MAPK3 PTPN7 PSMB7 PPP1CC PSMB4 GFRA3 PSMB5 GFRA2 PSMB2 DUSP16 PSMB3 PSMB1 DUSP10 PSMF1 GFRA4 LAMTOR2 PSMB8 IL6R DUSP8 PSMB9 LAMTOR3 DUSP9 SEM1 MRAS PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 KIT PSMC2 SHOC2 RANBP9 PPP5C FYN SHC1 EGF PIK3R1 EGFR NRAS MAP3K11 PIK3CA RASGRF2 SOS1 HRAS PSPN RASGRF1 GDNF PIK3R2 IL6 IL2RG PDE6D CSK IL2RA IL2RB NCAM1 IRS1 PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG MET PDGFB TGFA SHC2 SHC3 RALGDS SPTBN1 EPGN PTK2 PTPRA SPTAN1 ARL2 SPTB FGF16 FGF7 FGF18 DUSP4 PPP2R5D DUSP6 DUSP7 PPP2R1B RASGRP3 IL2 IL3 IL5 DUSP5 DUSP2 DUSP1 PAQR3 PTPN3 WDR83 RCE1 ICMT RGL3 FGB RGL1 FGA RGL2 VWF PEA15 IL17RD RAPGEF2 USP17L2 RASGEF1A ABHD17C FGG ABHD17B ABHD17A GOLGA7 ZDHHC9 ARTN ERBB2 PHB1 LYPLA1 ITGB3 ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 APBB1IP INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 80%175567 Integration of viral DNA into host genomic DNA PSIP1 BANF1 HMGA1 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 80%9025046 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 MITOPHAGY%REACTOME%R-HSA-5205647.4 Mitophagy SQSTM1 UBA52 PRKN MFN1 TOMM70 MFN2 ATG12 VDAC1 TOMM20 TOMM22 UBB UBC TOMM40 RPS27A ULK1 ATG5 MTERF3 MAP1LC3B CSNK2A1 MAP1LC3A CSNK2A2 FUNDC1 TOMM7 TOMM5 TOMM6 CSNK2B PINK1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 80%75876 Synthesis of very long-chain fatty acyl-CoAs TECR ELOVL1 HACD1 HSD17B3 TECRL HACD3 ACSL1 HACD2 ELOVL5 HACD4 ELOVL2 ELOVL3 HSD17B12 ACSL4 ACSL3 ELOVL4 ELOVL6 ACSL6 ELOVL7 ACSL5 ACSBG1 ACSBG2 ACSF3 SLC27A3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.4 MyD88 dependent cascade initiated on endosome IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 TICAM2 CHUK TLR9 MAPKAPK3 MAPKAPK2 TLR7 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A LY96 CD14 DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N TLR4 MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 TICAM1 CUL1 ELK1 CREB1 UBB MAP2K1 IRF7 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER S100A12 ECSIT MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.2 Regulation of gap junction activity TJP1 GJA1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.1 Resistance of ERBB2 KD mutants to neratinib CDC37 HSP90AA1 ERBB2 ERBIN LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.2 Lagging Strand Synthesis RPA3 POLA1 POLA2 DNA2 PRIM2 PCNA POLD3 PRIM1 POLD4 POLD1 RPA1 POLD2 RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 FEN1 RPA2 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.2 Prevention of phagosomal-lysosomal fusion RAB7A RPS27A RAB5A UBB VPS33B UBA52 CORO1A HGS UBC NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.1 NRAGE signals death through JNK TIAM2 BAD FGD1 FGD2 FGD3 ARHGEF10L FGD4 KALRN MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 NET1 ARHGEF17 ARHGEF16 ARHGEF19 VAV3 ARHGEF18 AKAP13 MAPK8 GNA13 ARHGEF9 ARHGEF3 ARHGEF4 OBSCN ARHGEF1 ARHGEF2 TRIO ARHGEF7 ARHGEF5 ARHGEF6 PLEKHG5 PREX1 ITSN1 RAC1 VAV1 RASGRF2 SOS1 VAV2 TIAM1 PLEKHG2 NGEF ARHGEF40 NGFR NGF SOS2 MAGED1 ARHGEF26 ABR BCL2L11 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 AATF ECT2 ARHGEF39 MCF2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 80%77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ECI1 HADHA ACADL ACADM DECR1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 80%8853884 Transcriptional Regulation by VENTX ANAPC11 TNRC6B FZR1 CDC23 CCND1 CDC26 CDC27 VENTX MOV10 ANAPC7 UBE2C UBE2E1 EHMT1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 TP53 ANAPC2 TCF7L2 CSF1R RELA LEF1 CTNNB1 AGO3 AGO4 AGO1 IL6 NFKB1 CDKN2A CEBPB EHMT2 TNRC6C ANAPC15 UBE2D1 ANAPC16 TNRC6A ANAPC10 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.1 Gap junction trafficking GJD2 GJD4 GJD3 CLTC CLTA GJA1 CLTCL1 GJA3 GJA5 GJA4 GJA9 GJA8 GJB2 GJB1 GJC1 GJC2 MYO6 GJA10 GJB4 GJB3 GJB6 AP2M1 DNM1 DAB2 GJB5 DNM2 GJB7 CLTB REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.2 Regulation of TP53 Activity through Association with Co-factors TP63 TP73 TP53BP2 POU4F2 BANP AKT3 PHF20 ZNF385A AKT2 PPP1R13B AKT1 PPP1R13L TP53 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.3 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling TLR7 UBE2N IRAK4 IRAK1 UBE2V1 TRAF6 MYD88 TLR9 IRF7 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 80%171007 p38MAPK events MAPKAPK2 RALGDS HRAS RALA MAPK14 RALB MAPK11 MAPK12 MAPK13 NRAS MAPKAPK3 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 80%168274 Export of Viral Ribonucleoproteins from Nucleus NUP62 NUP214 NDC1 SEC13 NUP210 HSPA1A NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 XPO1 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAN RAE1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 80%6804756 Regulation of TP53 Activity through Phosphorylation TAF9B HIPK1 HIPK2 PRKAA1 PRKAA2 RAD1 PRKAG1 PRKAG2 PRKAG3 STK11 SUPT16H RFC5 MAPK14 RFC3 CDK2 RFC4 PRKAB2 BLM MAPKAPK5 RFC2 TP53 RPA2 MRE11 PRKAB1 WRN RPA3 AURKB CHEK2 CSNK2A1 TAF4B RAD9B CSNK2A2 RAD9A BRIP1 MDM2 DYRK2 KAT5 RPA1 MDM4 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 CSNK2B MAPK11 TOP3A RAD50 TAF9 TAF1L TP53INP1 CDK5R1 TAF15 PLK3 TAF12 TAF13 CCNA2 CCNA1 TAF10 TAF11 TBP UBA52 SSRP1 TAF7 TAF6 DNA2 TAF5 TAF4 TAF3 TAF2 TP53RK TAF1 NOC2L AURKA HUS1 UBB UBC CDK5 RHNO1 RPS27A NUAK1 ATRIP TPX2 RAD17 CHEK1 ATR TAF7L PIN1 BRCA1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 80%205043 NRIF signals cell death from the nucleus MAPK8 NGFR RPS27A NGF APH1A PSENEN TRAF6 SQSTM1 APH1B PSEN2 UBA52 PSEN1 UBB ITGB3BP NCSTN UBC PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 80%8963691 Phenylalanine and tyrosine metabolism GSTZ1 FAH HPD ASRGL1 KYAT1 QDPR IL4I1 PAH HGD TAT PCBD1 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 80%888568 GABA synthesis GAD1 GAD2 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 80%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TRMT5 TRMT12 TYW1 LCMT2 TYW5 TYW3 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 80%351906 Apoptotic cleavage of cell adhesion proteins DSP CASP3 DSG1 CTNNB1 TJP1 PKP1 DSG3 OCLN CDH1 DSG2 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 80%181430 Norepinephrine Neurotransmitter Release Cycle RAB3A MAOA SLC22A2 SLC22A1 UNC13B SYT1 CPLX1 SNAP25 STX1A RIMS1 PPFIA1 VAMP2 PPFIA4 TSPOAP1 PPFIA3 PPFIA2 SLC18A2 SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.1 Signaling by RAS GAP mutants KRAS HRAS NRAS SIGNALING BY ERBB2 ECD MUTANTS%REACTOME%R-HSA-9665348.2 Signaling by ERBB2 ECD mutants ERBB2 ERBIN SHC1 EGF GAB1 PIK3R1 EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 80%9670095 Inhibition of DNA recombination at telomere H2AX H3-3B H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 DAXX POT1 TERF2IP H2BU1 ATRX H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 POLR2A H2BC13 POLR2B H2BC14 POLR2C H2AJ POLR2D H2BC15 H2BC11 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J H2AZ1 POLR2K H2BC9 POLR2L H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.1 FBXW7 Mutants and NOTCH1 in Cancer SKP1 CUL1 RBX1 NOTCH1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.1 NOTCH4 Activation and Transmission of Signal to the Nucleus PSEN1 APH1A PSENEN APH1B JAG1 PSEN2 ADAM10 NCSTN NOTCH4 YWHAZ DLL4 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 80%983712 Ion channel transport FXYD1 FXYD7 ATP6V1B2 ATP6V0D1 FXYD6 RAF1 ANO2 ATP6V0C ATP6V0D2 ATP6V1B1 BEST2 SLC9C1 BEST3 NEDD4L SLC9C2 CAMK2B BEST1 BEST4 ATP8A1 SLC9B1 CAMK2D SLC9B2 TTYH3 TTYH2 CAMK2A CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 WNK1 WNK2 CALM1 WNK3 CAMK2G UNC80 ATP7A TSC22D3 ANO9 WWP1 ANO7 ANO4 ANO5 ANO3 ANO1 SGK3 ATP8B4 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 STOM CLCA3P TPCN2 TPCN1 CLCN7 CLCN5 CLCN4 OSTM1 UNC79 ATP11B CLCN6 ATP11A ATP2A3 ATP2A2 ATP2A1 ATP8A2 ATP12A RYR1 ATP11C RYR2 RYR3 SLN ATP8B3 ANO6 ATP8B2 CLIC2 ATP8B1 TRDN ASPH PLN ATP7B FKBP1B ATP10D ATP10B ATP10A ATP9B ATP9A SRI ATP4B ATP4A ATP2B4 CUTC ATP2B3 ATP2B2 ATP2B1 ATP2C2 ATP2C1 ATP13A1 ATP13A4 ATP13A5 ATP13A2 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 SCNN1G TRPC7 TRPC5 SCNN1D MCOLN3 SCNN1B TRPC6 SCNN1A TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 UBA52 PDZD11 UBB ANO8 UBC RPS27A ATP6V1H ATP6V1A TCIRG1 ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP1B3 ATP6V0E2 ATP1B2 ATP6V1G3 ATP6V1E2 ATP1B1 ATP6V1D ATP6V1C1 ATP1A4 ATP6V0A1 ATP1A3 ATP6V1F ATP1A2 ATP6V1C2 ATP1A1 ATP6V1G1 ATP6V0B SGK1 ATP6V0E1 FXYD4 ATP6V1G2 FXYD3 FXYD2 ATP6AP1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 80%3858494 Beta-catenin independent WNT signaling PSMD8 PRKCG PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 MAP3K7 NFATC1 PRKCB PSMA5 PSMA6 CAMK2A PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 WNT1 CALM1 PSMD13 PSMA7 TCF7L2 TCF7L1 TCF7 PSMB10 LEF1 PSMA8 PSMB6 CTNNB1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DVL1 DVL2 PLCB3 DVL3 PLCB1 CLTC PLCB2 SCRIB CLTA RAC1 RAC3 WNT4 VANGL2 WNT5B ROR1 ROR2 PRICKLE1 SMURF2 SMURF1 RHOA PARD6A FZD1 FZD8 PRKG2 RYK CLTB PFN1 ITPR1 ITPR2 ITPR3 MOV10 RAC2 AGO3 GNG10 AGO4 AGO1 AGO2 GNG12 GNG11 GNG13 PPP3CA GNB2 GNB1 GNB4 FZD7 GNB3 GNB5 TNRC6C GNGT1 TNRC6A TNRC6B GNGT2 UBA52 GNG3 GNG2 GNG5 UBB GNG4 DAAM1 PPP3R1 GNG7 GNG8 UBC RPS27A PPP3CB AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 GNAT2 PRKG1 WNT5A NLK ARRB2 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 PDE6G FZD4 FZD6 GNAO1 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 80%5693538 Homology Directed Repair HERC2 SUMO2 RAD51B RAD51C PIAS4 PARP1 RAD1 RNF168 CDK2 BLM MRE11 WRN SEM1 UBE2N RAD9B RAD9A RPA1 ATM RAD52 BABAM1 TOPBP1 BABAM2 UIMC1 FEN1 ABRAXAS1 RNF8 BRCC3 TP53BP1 UBE2V2 CCNA2 SIRT6 CCNA1 DNA2 RTEL1 POLQ NSD2 H3-4 CHEK1 RNF4 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 CLSPN RFC4 RFC1 RFC2 RPA2 XRCC1 LIG3 POLE4 RPA3 MUS81 POLE2 EME1 POLE3 EME2 POLH GEN1 SLX1B SPIDR SLX4 XRCC3 BRCA2 RAD51AP1 BRIP1 KAT5 UBE2I EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51D RAD50 RAD51 H2AX H2BC12L PPP4R2 TIPIN UBA52 H2BC21 TIMELESS PPP4C H2BU1 ABL1 H2BC17 H2BC12 H2BC13 H2BC14 HUS1 H2BC15 H2BC11 UBB UBC RHNO1 H2BC9 RPS27A PARP2 ATRIP H4C9 H2BC8 H2BC5 RAD17 H2BC3 ATR H2BC1 ERCC4 ERCC1 MDC1 BRCA1 INTEGRATION OF ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 80%163685 Integration of energy metabolism PRKCA PRKAA2 PRKAG2 STK11 PFKFB1 CACNA1D CACNA1C PRKAB2 SLC2A1 PPP2CA PPP2CB RAPGEF3 RAPGEF4 KCNJ11 ABCC8 AKAP5 TALDO1 ACLY KCNG2 TKT PLCB3 MARCKS PLCB1 PLCB2 SNAP25 KCNC2 SYT5 MLX PRKACG PRKACB CHRM3 ADCY9 PRKAR1B PRKAR1A SLC2A2 PRKAR2A KCNB1 GNAS KCNS3 AGPAT1 AHCYL1 ADCY4 ADCY3 ADCY2 ADCY1 ADIPOQ ADCY8 ADCY7 ADCY6 ITPR1 ADCY5 ITPR2 ADRA2C ITPR3 ADRA2A CYSLTR2 MLXIPL FFAR1 CACNB2 CACNB3 GNG10 PPP2R1A GNG12 PRKACA GNG11 GLP1R PPP2R5D GNG13 ACSL4 ACSL3 ACACB GNAQ STXBP1 ACACA GNB2 PPP2R1B GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 CACNA1A CACNA1E STX1A GNAI1 FASN GNAI2 GNA14 CACNA2D2 GNA15 GNG3 GNG2 GCG GNG5 GNG4 GNA11 PRKAR2B GNG7 GNG8 IQGAP1 CD36 INS ADIPOR1 ADIPOR2 VAMP2 RAP1A UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%2142789 Ubiquinol biosynthesis COQ6 COQ2 COQ5 COQ3 PDSS2 PDSS1 COQ9 COQ7 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.2 RHO GTPases activate CIT CIT RHOA PPP1CB PPP1R12B RAC1 RHOC RHOB MYL12B MYH9 MYH14 MYH11 PPP1R12A MYH10 MYL6 PRC1 DLG4 KIF14 CDKN1B MYL9 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 80%9020558 Interleukin-2 signaling IL2RG JAK1 STAT5A LCK IL2 STAT5B IL2RA IL2RB SHC1 SYK PTK2B JAK3 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 80%1483148 Synthesis of PG PLD4 PLD6 PLD1 PLD3 CDS2 PLD2 PGS1 PTPMT1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%R-HSA-113507.3 E2F-enabled inhibition of pre-replication complex formation CDK1 ORC5 ORC4 MCM8 CCNB1 ORC6 ORC1 ORC3 ORC2 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 80%164843 2-LTR circle formation XRCC6 PSIP1 XRCC5 LIG4 BANF1 XRCC4 HMGA1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022870.2 Chondroitin sulfate biosynthesis CHST7 CSPG4 CHPF2 DCN CHST3 BCAN CHPF CHSY3 CSGALNACT1 CSGALNACT2 NCAN CHST11 CHST12 BGN CHST15 CHST13 VCAN CHSY1 CSPG5 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.6 SLC transporter disorders SLC11A2 NUP62 NUP214 NDC1 SLC40A1 SEC13 CP NUP210 NUP133 SLCO1B1 SLC9A6 SLC5A2 RHAG SLC4A1 SLCO1B3 NUP93 SLC9A9 SLC34A3 SLC34A2 SLC35A2 SLC34A1 SLC35A1 NUP50 SLC35A3 NUP54 SLC33A1 SLC35C1 NUP205 POM121 SLC2A9 SLCO2A1 AAAS SLC2A1 NUP160 AVP POM121C NUP42 SLC16A1 SLC4A4 NUP85 SLC6A19 SLC12A6 SLC6A18 TPR SLC29A3 NUP88 NUP43 RAE1 SLC6A14 RANBP2 SLC27A4 SLC26A2 SLC1A1 SLC6A20 NUP155 SLC6A2 SLC2A10 SLC1A3 SLC6A3 SLC5A7 SLC6A5 SLC5A5 SLC5A1 NUP153 SLC22A18 HK1 NUP35 NUP37 AVPR2 SLC26A4 SLC26A3 SLC22A5 SLC22A12 SLC7A9 SLC36A2 SLC7A7 SLC3A1 SLC24A1 SLC24A4 SLC20A2 GCKR SLC3A2 SLC17A8 AVPR1B AVPR1A SLC12A3 BSG SLC12A1 SLC24A5 SLC2A2 HEPH SLC39A4 NUP107 NUP188 SLC17A5 GCK EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 80%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDKN2A CDK4 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.3 Notch-HLH transcription pathway NCOR1 TBL1XR1 HDAC1 TBL1X NOTCH2 CREBBP NOTCH3 NOTCH1 HDAC10 MAML2 NOTCH4 HDAC2 MAML1 HDAC11 HDAC8 RBPJ KAT2B KAT2A SNW1 HDAC9 MAML3 MAMLD1 HDAC6 HDAC7 HDAC4 HDAC5 NCOR2 HDAC3 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702620 quizartinib-resistant FLT3 mutants FLT3 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.2 Zinc transporters SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 80%451308 Activation of Ca-permeable Kainate Receptor NCALD DLG1 DLG3 GRIK5 GRIK3 DLG4 GRIK4 GRIK1 GRIK2 CALM1 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 80%177162 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B TP53 REGULATES METABOLIC GENES%REACTOME DATABASE ID RELEASE 80%5628897 TP53 Regulates Metabolic Genes TIGAR COX6C LRPPRC PRKAA1 AKT3 PRKAA2 MOV10 YWHAB GPI PRKAG1 TACO1 PRKAG2 PRKAG3 YWHAQ COX6A1 RPTOR SESN3 SESN2 AKT2 YWHAH MLST8 AKT1 COX6B1 SLC38A9 PRKAB2 TP53 COX19 YWHAZ COX16 TSC2 COX18 TSC1 YWHAE PRKAB1 MTOR COX11 COX14 RRAGA RRAGC AGO3 RHEB AGO4 RRAGB AGO1 AGO2 RRAGD LAMTOR2 LAMTOR1 PTEN LAMTOR4 LAMTOR3 CYCS LAMTOR5 YWHAG COX20 G6PD COX4I1 TNRC6C GPX2 RRM2B TNRC6A TP63 GLS2 TNRC6B PRDX2 PRDX1 NDUFA4 TXNRD1 MT-CO1 GLS COX7A2L SCO1 SCO2 DDIT4 MT-CO2 MT-CO3 SURF1 SFN COX7B COX7C COX8A COX5B COX5A NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.1 Negative regulation of FGFR3 signaling PPP2CA PPP2CB MKNK1 RPS27A MAPK1 SPRY2 MAPK3 FGF16 PPP2R1A FGF18 UBA52 CBL FRS2 PTPN11 FGF1 FGF2 FGF4 UBB FGF9 FGF20 BRAF UBC FGF23 VRNA SYNTHESIS%REACTOME%R-HSA-192814.3 vRNA Synthesis PARP1 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.1 Uptake of dietary cobalamins into enterocytes ABCD4 PRSS1 CBLIF CTRB2 CTRB1 CUBN LMBRD1 TCN1 AMN PRSS3 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.2 Defective Base Excision Repair Associated with NEIL1 NEIL1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 80%156588 Glucuronidation UGT3A2 UGT3A1 UGDH SLC35D1 UGP2 UGT1A3 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A9 UGT1A8 UGT1A7 UGT1A6 UGT1A4 ABHD10 UGT1A10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 80%3301854 Nuclear Pore Complex (NPC) Disassembly NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 CCNB2 NUP205 CCNB1 POM121 AAAS NUP160 NEK9 POM121C NEK6 NUP42 NEK7 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 CDK1 NUP153 NUP107 NUP188 NUP35 NUP37 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022923.1 Dermatan sulfate biosynthesis DSE CSPG4 DCN NCAN DSEL BGN CHST14 VCAN UST BCAN CSPG5 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 80%450520 HuR (ELAVL1) binds and stabilizes mRNA XPO1 ANP32A PRKCA PRKCD NUP214 SET TNFSF13 ELAVL1 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 80%2408552 Methylation of MeSeH for excretion INMT INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 80%166663 Initial triggering of complement IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 C4B_2 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRP IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MBL2 C1S C1R C4A C1QB C1QA C1QC FCN1 FCN2 FCN3 MASP1 C3 CFD GZMM CFB COLEC11 COLEC10 C2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 TNF SIGNALING%REACTOME DATABASE ID RELEASE 80%75893 TNF signaling IKBKB USP21 BAG4 TNFAIP3 RBCK1 CASP8 IKBKG MAP3K7 CHUK UBA52 XIAP TNF TRAF2 UBB SPPL2B UBC TAX1BP1 SPPL2A RPS27A USP4 USP2 CLIP3 OTULIN NSMAF RIPK1 SHARPIN FADD ADAM17 TAB3 TAB2 TRADD CYLD TAB1 OTUD7B SMPD3 SMPD2 RACK1 TRAF1 TNFRSF1A BIRC2 BIRC3 RNF31 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%R-HSA-76002.3 Platelet activation, signaling and aggregation TLN1 RAF1 VCL ACTN2 SRC TGFB2 CD9 TGFB3 AHSG PRKCQ RASGRP2 RASGRP1 CALM1 YWHAZ TBXA2R LYN CLU GNA13 LAMP2 PDPK1 CD109 LAT PIK3R6 CRK IGF1 ALDOA PLA2G4A RAB27B MGLL STXBP2 PECAM1 PRKCE ITPR1 HSPA5 ORM1 ITPR2 ADRA2C ORM2 ITPR3 ADRA2B ADRA2A PDPN CLEC1B MPIG6B GP6 MAPK14 PLCG2 VAV3 SYK LCP2 PTPN6 CFD TRPC7 TRPC6 SERPINE1 TRPC3 APP TUBA4A PRKCD ISLR CHID1 SERPINF2 GTPBP2 SYTL4 NHLRC2 ENDOD1 PRKCZ VTI1B HRG FERMT3 SERPINA4 TMSB4X TIMP3 ANXA5 SOD1 PCYOX1L DGKG DGKE DGKD DGKB DGKA DGKZ DGKQ DGKK PPIA TTN DGKI DGKH SCCPDH PTPN11 WDR1 PHACTR2 ITIH4 ITIH3 CLEC3B CDC37L1 HABP4 ACTN4 PRKCG TAGLN2 PRKCA TEX264 APOH MANF MAGED2 ECM1 OLA1 CTSW TOR4A STXBP3 LY6G6F APOOL LHFPL2 POTEKP PRKCB FAM3C TMX3 SELENOP FLNA RARRES2 CYRIB LGALS3BP PLEK SRGN MMRN1 AKT1 PRKCH P2RY12 RAPGEF3 RAPGEF4 MAPK1 MAPK3 STX4 CFL1 BRPF3 F2RL2 F2RL3 AAMP PTPN1 TGFB1 ABHD12 DAGLA ABHD6 DAGLB MPL THPO CDC42 LCK FYN RAC1 SHC1 PIK3CG EGF PIK3R5 PIK3R1 VAV1 PIK3CA SOS1 VAV2 P2RY1 THBS1 RHOA PIK3R2 QSOX1 CSK PCDH7 LEFTY2 ACTN1 A2M CD63 PFN1 PIK3CB APOA1 HGF ALB CYB5R1 PIK3R3 PDGFB GNAT3 TIMP1 PTK2 PPBP RAC2 PSAP GNG10 RHOG GNG12 GNG11 RHOB GNG13 GNAQ GNB2 PLG GNB1 GNB4 IGF2 PROS1 GNB3 F13A1 FCER1G GNB5 KNG1 GNGT1 BCAR1 GNGT2 FGB FGA VWF APLP2 GP1BB F2R SCG3 FGG GP1BA F2 SPARC GP5 F5 GNAI3 GP9 SELP GNAI1 F8 GNAI2 GNA14 TF CALU SERPING1 GNA15 GNG3 PF4 GNG2 A1BG GNG5 GNG4 GNA11 GNG7 GNG8 GAS6 CD36 SERPINA3 CAP1 SPP2 SERPINA1 GNA12 ITGB3 ITGA2B VEGFB ARRB1 VEGFC ARRB2 VEGFD RAP1B RAP1A VEGFA FN1 APBB1IP ABCC4 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 80%164952 The role of Nef in HIV-1 replication and disease pathogenesis AP1M2 AP1M1 PACS1 LCK CD28 FYN RAC1 PAK2 AP1G1 HCK DOCK2 ARF1 CD4 CD8B AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 AP1B1 HLA-A ELMO1 AP1S2 AP1S1 B2M AP1S3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 80%382556 ABC-family proteins mediated transport PSMD8 PSMD9 ABCC5 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ABCC3 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 ABCA4 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 KCNJ11 PSMB2 ABCC9 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 ABCC1 PSMC6 ABCB1 PSMC3 PSMC4 PSMC1 PSMC2 VCP SEL1L DERL2 ERLEC1 OS9 ABCA12 ABCA10 ABCB6 ABCB7 ABCB5 ABCB8 ABCB9 EIF2S2 ABCA2 EIF2S1 ABCA5 ABCA9 EIF2S3 ABCA7 ABCA8 ABCC10 ABCC11 ABCB10 RNF5 RNF185 CFTR APOA1 ABCD2 ABCG1 PEX3 DERL1 ABCG4 DERL3 ERLIN1 ABCF1 PEX19 ABCG8 ABCG5 ABCA3 ABCB4 ERLIN2 UBA52 UBB ABCC6 UBC RPS27A ABCD1 ABCC2 ABCA6 ABCC4 DEFECTIVE SLC6A18 MAY CONFER SUSCEPTIBILITY TO IMINOGLYCINURIA AND OR HYPERGLYCINURIA%REACTOME DATABASE ID RELEASE 80%5659729 Defective SLC6A18 may confer susceptibility to iminoglycinuria and or hyperglycinuria SLC6A18 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.2 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNE5 CACNB1 CACNB2 AKAP9 KCNQ1 CACNG8 CACNA1C CACNA2D2 CACNG6 CACNG7 CACNG4 KCNE1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 80%109606 Intrinsic Pathway for Apoptosis BAD CASP9 E2F1 AKT3 GSDMD YWHAB NMT1 PPP3CC YWHAQ CASP3 TFDP1 XIAP AKT2 YWHAH TFDP2 AKT1 CARD8 BMF TP53 AVEN YWHAZ BAX APIP BID YWHAE MAPK8 PMAIP1 MAPK1 MAPK3 UACA CYCS YWHAG CDKN2A PPP1R13B APAF1 C1QBP TP63 TP73 DYNLL1 BCL2L1 CASP8 BAK1 GZMB CASP7 DIABLO BCL2 PPP3R1 TP53BP2 STAT3 BCL2L11 GSDME SFN BBC3 DYNLL2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 80%69206 G1 S Transition PSMD8 PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 TFDP1 PSMA1 CCNE2 PSMA2 AKT2 PSME3 TFDP2 PSME1 CDK4 AKT1 CCNE1 PSME2 CABLES1 PSMD10 CDK2 WEE1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB MYC PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 LIN54 PSMB9 SEM1 LIN52 PSMC5 PSMC6 PSMC3 RPA1 PSMC4 PSMC1 LIN37 PSMC2 PTK6 LIN9 PPP2R3B CKS1B HDAC1 MAX E2F5 FBXO5 CDC7 DHFR CCNA2 CCNA1 MCM10 TK1 DBF4 TYMS E2F6 PRIM2 RRM2 PRIM1 RPA4 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 POLA1 POLA2 CDC25A AKT3 PCNA POLE RPA2 POLE4 RPA3 POLE2 POLE3 PPP2R1A PPP2R1B SKP1 RBL2 RBL1 CCNH E2F4 UBA52 CUL1 CCNB1 UBB RBBP4 UBC CDK7 MNAT1 RPS27A CDK1 CDC45 MCM7 MCM8 RB1 CDKN1A MCM3 MCM4 CDKN1B MCM5 MCM6 MCM2 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.2 Pausing and recovery of HIV elongation ELOB ELOC TCEA1 SSRP1 CCNT2 CCNT1 CCNK POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE ELOA2 SUPT5H CDK9 ELL ELOA HCMV INFECTION%REACTOME DATABASE ID RELEASE 80%9609646 HCMV Infection UBAP1 CHMP4A CHMP6 CHMP7 VPS25 NUP62 NUP214 VPS28 NDC1 SEC13 NUP210 NUP133 DAXX H2AW H2AC17 H2AC12 H2AC1 H2BC18 H3C15 NUP93 H2AC21 NUP50 NUP54 NUP205 POM121 AAAS NUP160 CHMP1A CBX1 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NFKB1 NUP155 ITGB1 NUP153 PML NUP35 NUP37 NCOR2 HDAC3 NCOR1 TBL1XR1 GPS2 TBL1X EGFR EZH2 TRIM28 SUZ12 EED DYNLL1 H2AC19 DYNC1I1 H2AC14 H2BC21 H2BU1 H2AC8 CEBPD H2AC6 H2AC7 DYNC1I2 H2BC17 H2BC12 H2BC13 ELK1 H2BC14 DYNC1LI1 CREB1 H2BC15 DYNC1LI2 H2BC11 HNRNPK RBBP4 RBBP7 H2BC9 H4C9 H2BC8 DYNC1H1 H2BC5 H2BC3 H2BC1 TSG101 H2AC20 VPS4A MVB12B MVB12A VPS36 VPS37C VPS37D VPS37A SNF8 NUP107 VPS37B NUP188 CHMP2B H3C8 CHMP4C CHMP2A CHMP4B DYNLL2 CHMP3 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.2 TLR3-mediated TICAM1-dependent programmed cell death TICAM1 TLR3 CASP8 RIPK1 FADD RIPK3 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 80%5357786 TNFR1-induced proapoptotic signaling USP21 USP4 USP2 TNFAIP3 CASP8 RIPK1 FADD TRADD CYLD OTUD7B TRAF2 TNF TNFRSF1A ABC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 80%5619084 ABC transporter disorders PSMD8 PSMD9 PSMD6 PSMD7 RNF185 PSMD4 APOA1 CFTR PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 DERL1 PSMD11 PSMD14 DERL3 PSMD13 ERLIN1 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 KCNJ11 ABCC8 PSMB2 ABCC9 PSMB3 PSMB1 PSMF1 ABCG8 PSMB8 ABCG5 PSMB9 ABCD4 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LMBRD1 ABCA3 ABCB4 ERLIN2 UBA52 VCP SEL1L DERL2 ERLEC1 OS9 ABCA1 ABCC6 UBB UBC ABCA12 RPS27A ABCB6 ABCB11 ABCD1 ABCC2 RNF5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.1 MyD88 cascade initiated on plasma membrane IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 TLR10 DUSP6 NFKBIA MAP2K3 DUSP7 TLR5 UBE2N MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB MAP2K1 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER S100A12 ECSIT MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 80%937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 RPS27A TRAF6 LY96 CD14 MAP3K7 TICAM2 UBA52 TAB3 TLR4 TAB2 TICAM1 TAB1 UBB UBC MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 80%5683057 MAPK family signaling cascades CNKSR1 KRAS TLN1 RAF1 NRTN VCL CAMK2B CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2B PRKCQ GRIN1 GRIN2D DLG1 SPTA1 DLG2 DLG3 LRRC7 DLG4 NEFL RASGRP1 CALM1 RASGRP4 CAMK2G CSF2 IL5RA IL3RA BCL2L1 MAPK12 BTC NRG3 NRG4 NRG2 HBEGF EREG MAP2K1 PRKACG PRKACB PPP2R5E PRKG2 RET PPP2R5B PPP2R5A PPP2R5C CDC14A CSF2RB CSF2RA FLT3 MOV10 KLB JUN SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 IRS2 FGF19 RASA1 PPP1CB RASA2 AGO3 CUL3 FOXO1 FGFR4 RASAL1 AGO4 RASAL2 PPP2R1A AGO1 RASAL3 AGO2 DAB2IP NF1 KBTBD7 PRKACA TNRC6C TNRC6A TNRC6B UBA52 ANGPT1 TEK FRS2 FRS3 FGF1 FGF2 FGF3 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 FGF22 FGF10 JAK1 RPS27A IQGAP1 TYK2 FNTA FNTB CDK1 SPTBN4 PTPN11 SPTBN5 RBX1 JAK2 PSMD8 PSMD9 CDC42EP5 CCND3 PSMD6 PSMD7 CDC42EP3 PSMD4 CDC42EP2 PSMD5 PSMD2 SPTBN2 PSMD3 PSMD1 YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 MAPKAPK5 PSMD11 PSMD14 PSMD13 BRAF JAK3 PSMA7 PPP2CA PPP2CB MYC PSMB10 MAPK1 PSMA8 GFRA1 PSMB6 MAPK3 PTPN7 PSMB7 PPP1CC PSMB4 GFRA3 PSMB5 GFRA2 PSMB2 DUSP16 PSMB3 PSMB1 DUSP10 PSMF1 GFRA4 LAMTOR2 PSMB8 IL6R DUSP8 PSMB9 LAMTOR3 DUSP9 SEM1 MRAS PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 KIT PSMC2 SHOC2 RANBP9 CDC42 PAK1 PPP5C FYN RAC1 SHC1 PAK3 EGF PAK2 PIK3R1 EGFR NRAS MAP3K11 PIK3CA HSPB1 RASGRF2 SOS1 HRAS IGF2BP1 PSPN RASGRF1 GDNF PIK3R2 IL6 IL2RG PDE6D CSK IL2RA IL2RB NCAM1 IRS1 PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG MET PDGFB TGFA KALRN SHC2 SHC3 RALGDS SPTBN1 EPGN PTK2 DNAJB1 XPO1 PTPRA SPTAN1 ARL2 SPTB FGF16 FGF7 FGF18 DUSP4 PPP2R5D DUSP6 DUSP7 PPP2R1B RASGRP3 IL2 IL3 IL5 DUSP5 DUSP2 DUSP1 PAQR3 PTPN3 WDR83 RCE1 ICMT RGL3 FGB RGL1 FGA RGL2 VWF PEA15 IL17RD RAPGEF2 USP17L2 RASGEF1A ABHD17C FGG ABHD17B ABHD17A RAG2 RAG1 GOLGA7 FOXO3 ZDHHC9 ARTN ERBB2 PHB1 LYPLA1 NCOA3 ITGB3 ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 CDC14B KSR1 FN1 ETV4 KSR2 MAPK6 CNKSR2 MAPK4 APBB1IP SEPTIN7 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 80%8851907 MET activates PI3K AKT signaling PIK3CA HGF GAB1 PIK3R1 MET THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.4 The retinoid cycle in cones (daylight vision) AWAT2 OPN1MW RBP3 OPN1LW DHRS3 OPN1SW RLBP1 ORGANIC ANION TRANSPORT%REACTOME DATABASE ID RELEASE 80%561048 Organic anion transport SLC22A6 SLC22A12 SLC22A8 SLC22A11 SLC22A7 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 80%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 80%388841 Costimulation by the CD28 family HLA-DPB1 TRIB3 MAPKAP1 HLA-DQA2 HLA-DQA1 AKT3 PIK3R3 PDCD1LG2 HLA-DRB5 HLA-DRB4 AKT2 MLST8 HLA-DQB2 HLA-DQB1 GRAP2 AKT1 RICTOR TRBV12-3 TRBV7-9 HLA-DRB3 HLA-DRB1 HLA-DRA PPP2CA PPP2CB TRAC MTOR PTPN6 LYN THEM4 PPP2R1A CD4 TRAV8-4 PRR5 PPP2R5D PPP2R1B BTLA CD86 CDC42 CD274 PAK1 PDPK1 LCK CD80 CD28 MAP3K14 FYN RAC1 TNFRSF14 PAK3 PAK2 VAV1 PIK3R1 PIK3CA TRBC1 TRAV19 MAP3K8 CD3G YES1 CD3E CD3D PIK3R2 CTLA4 HLA-DPA1 CSK ICOSLG PPP2R5E PTPN11 PPP2R5B PDCD1 PPP2R5A PPP2R5C TRAV29DV5 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.8 Cellular responses to stress BMI1 ATP6V1B2 ATP6V0D1 TLN1 ATP6V0C ATP6V0D2 NUP62 NUP214 ATP6V1B1 NDC1 SEC13 KDM6B NUP210 HSPA1B CAMK2B RING1 HSPA1A NUP133 CAMK2D CAMK2A NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 CAMK2G RNF2 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 CBX8 PHC2 PHC1 NUP155 CSNK2A1 CBX4 CDKN2A CSNK2A2 CBX2 RPA1 NUP153 PHC3 HYOU1 CSNK2B NUP35 NUP37 CUL7 PLA2G4B WIPI1 ATF2 ETS1 ETS2 MAP3K5 ERF TNIK TRIB3 ASF1A EP400 GSK3A HSPA5 HMGA2 ID1 HSPA6 CABIN1 AKT3 VENTX MOV10 MINK1 HIRA UBN1 EZH2 MAP4K4 CXCL8 NR3C2 DNAJA1 DNAJA4 DNAJA2 FKBP5 MAP2K4 SUZ12 MAP2K7 JUN FOS RPA2 MAPK9 YWHAE MAPK8 RPA3 MAPK10 EPO AGO3 ACTR1A AGO4 AGO1 CBX6 LY96 BTRC TLR4 EED SKP1 SSR1 KAT5 HSP90AA1 NBN CRTC2 CRTC3 TNRC6C CRTC1 RORA TNRC6A NR3C1 RAD50 TNRC6B BAG4 SLC7A11 DYNLL1 PRDX2 PSPHP1 PRDX1 CLOCK HIF1A SRPRA SRPRB NPAS2 UBA52 ARNTL RAI1 AJUBA NRIP1 NR1D1 DYNC1I2 DCTN2 MT-CO1 PRKCD EHMT1 DCTN3 CUL1 AR DYNC1LI1 DYNC1LI2 COX7A2L SCO1 UBB SCO2 MT-CO2 MT-CO3 UBC RPS27A HSPA9 DYNC1H1 SURF1 SOD2 SOD1 HMOX2 ATR COX7B COX7C EHMT2 COX8A RBX1 MEF2C COX5B DYNLL2 RPS6KA3 COX5A RPS6KA2 PSMD8 RPS6KA1 PSMD9 PSMD6 PSMD7 PSMD4 COX6C PSMD5 PSMD2 LRPPRC PSMD3 PSMD1 SQSTM1 MAP2K6 TXNIP PSMA5 PSMA6 TACO1 PSMA3 PSMA4 RPTOR COX6A1 PSMA1 PSMA2 SESN2 AKT2 PSME3 PSME4 MLST8 PSME1 AKT1 PSME2 SLC38A9 IL1A COX6B1 PSMD10 PSMB11 PSMD12 MAPKAPK5 PSMD11 COX19 PSMD14 RPS6 COX16 PSMD13 COX18 PSMA7 RELA MTOR COX11 PSMB10 GSTP1 PSMA8 COX14 PSMB6 RRAGA PSMB7 RRAGC PSMB4 PSMB5 RHEB PSMB2 RRAGB PSMB3 AKT1S1 PSMB1 RRAGD CALR PSMF1 LAMTOR2 LAMTOR1 NFKB1 PSMB8 LAMTOR4 PSMB9 LAMTOR3 LAMTOR5 CYCS SEM1 PSMC5 PSMC6 CEBPB PSMC3 COX20 PSMC4 PSMC1 PSMC2 COX4I1 RXRA ARNT LMNA NCF1 SZT2 CA9 ATF3 HIGD1A SEH1L NCF2 GPX2 NPRL2 STIP1 NPRL3 NCF4 NCOR2 GCN1 WDR59 HDAC3 NCOR1 ASNS EIF2AK4 TBL1XR1 FLCN MIOS SIN3A ITFG2 IMPACT DEPDC5 TBL1X HSP90B1 KPTN CEBPG NDUFA4 WDR24 SHC1 SH3BP4 TXNRD1 FNIP1 FNIP2 KICS2 CASTOR1 CASTOR2 PPARGC1A BMT2 CYBB CYBA CREB3L4 CREB3L1 CREB3L2 CREBRF HERPUD1 DCSTAMP CREB3 KHSRP PPARA EDEM1 MEF2D HBA2 HSPB8 HIKESHI CCAR2 HSBP1 DNAJC2 DNAJC7 FKBP4 CRYAB RPS19BP1 HSPA4L HSPA14 HSPA13 HDAC6 DNAJB1 BAG5 XPO1 HSPH1 DNAJB6 BAG2 BAG3 HSF1 BAG1 NCOA2 HSPA1L HSPA4 ST13 HSPA7 PTGES3 HSPA2 HSPA12A HSPA12B PGR MAPK7 SP1 HIF1AN IGFBP1 H2AX H2AB1 H2AC19 PDIA6 DYNC1I1 H2AC14 H2BC12L ACTR10 H2BC21 IGFBP7 H2BU1 WFS1 H2AC8 H2AC6 H2AC7 EPAS1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RBBP4 RBBP7 H2AZ1 H2BC9 RPL4 RPL5 H2AZ2 RPL30 RPL3 RPL32 H4C9 RPL31 H2BC8 RPL34 RPLP1 RPL10L H2BC5 RPLP0 NCOA1 H2BC3 RPL10A RPL8 H2BC1 CAT RPL6 NCOA6 RPL7 ACADVL FKBP14 H2AC20 MYDGF RPS4X RPS15 TATDN2 TSPYL2 RPL7A DDX11 RPS14 RPS17 PDIA5 RPS16 ERN1 CTDSP2 RPS19 RPL18A DNAJB11 CXXC1 RPL36AL EXTL2 UBE2D2 RPS18 RPL36 EXTL1 RPL35 UBE2D1 DNAJB9 RPLP2 EXTL3 RPL38 ZBTB17 RPL37 KLHDC3 RPS11 YIF1A RPS10 HDGF RPL39 TPP1 RPS13 RPS12 RPS9 PPP1R15A RPL21 GSTA1 HMOX1 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 LMNB1 EEF1A1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 MRE11 RPL36A RPS27L ERO1A RPS4Y1 AQP8 RPS15A NUDT2 BACH1 RPL14 RPS3 TXN2 RPL13 SESN1 RPS2 MUL1 PRDX3 RPL15 RPL18 STAP2 CHD9 RPL17 GCLC NPLOC4 RPL19 NOX4 RPL39L RPL41 NOX5 RPL35A GCLM SRXN1 RPL23A MAP1LC3B RPL3L ME1 MAP2K3 RPS26 UBXN7 VHL RPS25 UFD1 RPS28 ABCC1 GPX1 RPS27 GPX3 RPS29 GPX6 RPL27A RPL22L1 GPX5 GPX8 RPS20 GPX7 FAU RPS21 BLVRB ARFGAP1 BLVRA MAPK11 RPL26L1 HM13 RPS24 TXNRD2 RPS23 FBXL17 SOD3 CCS GSTA3 H3-3B TINF2 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP CDKN2D CDKN2B CDKN2C MED1 PREB ACD KDELR3 EIF2S2 EIF2S1 H3-4 EIF2S3 GSK3B PPP2R5B EIF2AK1 NQO1 ATF5 HIF3A HMGA1 ELOB LIMD1 ELOC EGLN1 EGLN3 EGLN2 WTIP CREBBP NOTCH1 CLEC1B EP300 EIF2AK3 MAPK14 CAPZA3 GRB10 TP53 CUL3 NLRP3 CUL2 IDH1 DIS3 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 TGS1 HSP90AB1 EXOSC2 UBE2D3 EXOSC1 GOSR2 SIRT1 SMARCD3 MAFG MAFK HBB IFNB1 CAPZB RB1 CDKN1A H3C8 ANAPC15 CDKN1B ANAPC16 ANAPC10 ANAPC11 FZR1 HELZ2 SULT1A3 NFE2L2 CDC23 CDC26 CDC27 E2F1 E2F2 E2F3 SKP2 ANAPC7 DNAJC3 UBE2C MAPKAPK3 UBE2E1 MAPKAPK2 H3C15 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 CAPZA1 ANAPC2 CAPZA2 ATP7A MYC MAPK1 MAPK3 CCL2 CHAC1 ATOX1 MDM2 MDM4 G6PD ATM TALDO1 PTK6 PGD TKT SEC31A VCP SYVN1 IL6 CREB3L3 APOB CITED2 MBTPS1 APOA1 H1-1 H1-0 ALB H1-3 SERP1 H1-2 H1-5 P4HB H1-4 MBTPS2 SLC46A1 FABP1 ADD1 HSPA8 NFYA NFYB DDIT3 NFYC ATF6 ATF4 DCTN6 DCTN5 DCTN1 DCTN4 CARM1 GFPT1 CREB1 PRDX6 STAT3 ATP6V1H ATP6V1A TCIRG1 KEAP1 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 VEGFA ATP6V1F NUP107 TRIM21 ATP6V1C2 ATP6V1G1 NUP188 ATP6V0B ATP6V0E1 ATP6V1G2 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 80%9010642 ROBO receptors bind AKAP5 PRKACG ROBO2 PRKACB PRKCA AKAP5 PPP3CB PRKAR2A PRKACA LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 80%9658195 Leishmania infection IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 HMOX1 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 PYCARD IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 CALM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 AVP IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGHG3 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 PSTPIP1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRK IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB YES1 ADCY9 PRKAR1B PRKAR1A ADRB1 PRKAR2A ADRB2 HTR4 TAAR3P HTR6 GNAS HTR7 HRH2 PTGIR ELMO1 DRD1 AHCYL1 DRD5 FGR TAAR8 ADCY4 TAAR9 ADCY3 TAAR6 ADCY2 ADCY1 ADCY8 TAAR5 ADCY7 ADCY6 TAAR2 ADCY5 ITPR1 ITPR2 DPEP2 ITPR3 TAAR1 DPEP1 DPEP3 HCK ADRB3 PRKX MAPK14 PLCG2 JUN P2RX7 VAV3 SYK P2RX4 MAPK8 IAPP NLRP3 C3 PRKACA MYH2 CASP1 HSP90AB1 CYFIP2 WIPF1 WIPF2 WIPF3 ABL1 PRKAR2B CYSLTR1 GGT1 WNT5A NFKB2 ARPC1B ARPC1A GGT5 C3AR1 GSDMD TXNIP DOCK1 IL18 IL1A IL1B FCGR3A RELA MAPK1 MAPK3 FCGR1A NFKB1 FCGR2A NCKAP1 CYFIP1 DVL1 BRK1 DVL2 DVL3 CDC42 ARPC4 ARPC5 FYN RAC1 ARPC2 ARPC3 VAV1 PLCG1 CYBA NCK1 VAV2 ACTR3 ACTR2 CD3G NOXO1 IL10 IL6 CD163 PLK2 ADAM17 RHBDF2 MYH9 NCKAP1L WASF3 WASF1 WASF2 MYO1C BAIAP2 BTK ABI2 ENTPD1 ABI1 NOXA1 VIPR1 VIPR2 SCT ENTPD5 NOX1 RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 ACTB PTGDR LHCGR CTSG ADCYAP1 GNAZ PTK2 CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB WASL GPR83 GPR84 CRHR1 CRHR2 MYO5A GHRHR MC2R CALCR CGA GNG10 GPR15 MC1R RLN2 RLN3 GNG12 GPR27 GNG11 GLP1R GNG13 GPR25 GPR20 ADM GNB2 PTH1R FURIN MC4R GNB1 GNB4 MYO10 FZD7 GNB3 INSL3 TSHB GPR39 GPR32 GNB5 FSHB GLP2R GNGT1 AVPR2 WAS GPBAR1 GNGT2 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 MYO9B PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 P2RY11 GNG3 SCTR GCG CREB1 GNG2 GNG5 TSHR MEFV ACTG1 GNG4 POMC GHRH ADM2 GNG7 MC5R GNG8 VIP RAMP1 GPHB5 ELMO2 NCKIPSD SUGT1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 DEFENSINS%REACTOME DATABASE ID RELEASE 80%1461973 Defensins DEFB129 DEFB103B DEFB128 DEFB127 DEFB1 DEFB126 DEFB125 DEFB124 DEFB123 ART1 DEFB121 DEFB107B DEFA1B DEFB104B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB135 DEFA6 DEFB134 DEFA4 DEFB113 DEFB133 DEFA5 DEFB112 DEFB132 DEFA3 DEFB108B DEFB110 DEFB108C DEFB105B PRSS2 DEFB109B CD4 CCR6 TLR1 CCR2 DEFB106B TLR2 DEFB130A DEFB4B DEFB130B DEFB131A PRSS3 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 80%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 80%69183 Processive synthesis on the lagging strand RPA3 POLA1 POLA2 DNA2 PRIM2 PCNA POLD3 PRIM1 POLD4 POLD1 RPA1 POLD2 LIG1 FEN1 RPA2 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 80%5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 80%2454202 Fc epsilon receptor (FCERI) signaling IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 NFATC3 V2-15 NFATC2 NFATC1 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP1 CALM1 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 PDPK1 V1-3 IGKV3D-20 V5-6 TRAF6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 TXK AHCYL1 ITPR1 ITPR2 ITPR3 GRAP2 MAP2K4 PLCG2 MAP2K7 JUN VAV3 SYK FOS LCP2 MAPK9 MAPK8 MAPK10 BTRC SKP1 FBXW11 UBA52 CUL1 UBB UBC RPS27A MAP3K1 IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 IKBKG MAP3K7 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CARD11 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 BCL10 PSMA7 RELA MALT1 PSMB10 MAPK1 PSMA8 PSMB6 MAPK3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK1 FYN RAC1 PAK2 PIK3R1 VAV1 NRAS PIK3CA PLCG1 SOS1 HRAS VAV2 PIK3R2 LAT2 BTK PIK3CB GAB2 PPP3CA FCER1A FCER1G PPP3R1 PPP3CB ITK MS4A2 TEC UBE2D2 IGHV3-23 UBE2D1 IGLV IGLV2-8 IGKV1-16 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 80%77595 Processing of Intronless Pre-mRNAs PCF11 WDR33 NCBP1 NCBP2 CLP1 CSTF2T CPSF4 PABPN1 CPSF1 CSTF3 CPSF3 CPSF2 CSTF2 NUDT21 CSTF1 SYMPK CPSF7 FIP1L1 PAPOLA DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.3 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 80%174430 Telomere C-strand synthesis initiation CTC1 STN1 TINF2 ACD TERF1 TERF2 POLA1 POLA2 TEN1 POT1 TERF2IP PRIM2 PRIM1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 80%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1M2 PACS1 AP1M1 AP1B1 HLA-A AP1G1 AP1S2 AP1S1 B2M AP1S3 PEXOPHAGY%REACTOME DATABASE ID RELEASE 80%9664873 Pexophagy NBR1 RPS27A EPAS1 ATM USP30 PEX5 SQSTM1 UBB UBA52 MAP1LC3B UBC TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 80%8963684 Tyrosine catabolism GSTZ1 FAH HPD HGD TAT PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 80%5693616 Presynaptic phase of homologous DNA pairing and strand exchange RAD50 RAD51 RAD51B RAD51C RAD1 DNA2 RFC5 RFC3 HUS1 RFC4 BLM RFC2 RPA2 MRE11 RHNO1 WRN RPA3 ATRIP RAD17 CHEK1 ATR SEM1 BRCA2 RAD9B RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 XRCC2 TOP3A BRCA1 RAD51D INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 80%428543 Inactivation of CDC42 and RAC1 ARHGAP39 CDC42 SRGAP3 SRGAP1 SRGAP2 ROBO1 RAC1 SLIT2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.1 NOTCH2 intracellular domain regulates transcription RBPJ GZMB EP300 HES1 MAML3 HES5 CREB1 MAMLD1 NOTCH2 FCER2 MAML2 MAML1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 80%6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release BID TP63 TP73 PMAIP1 TP53INP1 TP53BP2 PRELID3A ZNF420 PRELID1 CREBBP BBC3 BNIP3L STEAP3 PPP1R13B ATM TRIAP1 TP53AIP1 AIFM2 TP53 BAX SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.3 Signaling by WNT in cancer LRP5 PORCN CSNK1A1 LRP6 WNT3A CTBP2 CTBP1 PPP2CA TCF7L2 PPP2CB AMER1 TNKS CTNNB1 DKK1 PPP2R1A DKK2 DKK4 PPP2R5D FZD8 PPP2R1B PPP2R5E GSK3B KREMEN1 APC KREMEN2 TNKS2 AXIN1 FZD5 PPP2R5B PPP2R5A RNF43 FZD4 PPP2R5C FZD6 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.1 Transferrin endocytosis and recycling MCOLN1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 TF STEAP3 HFE STEAP2 TFR2 ATP6V1H ATP6V1A TCIRG1 ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 ATP6V1F TFRC ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 80%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 80%75108 Activation of BID and translocation to mitochondria BID GZMB CASP8 NMT1 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 80%427975 Proton oligopeptide cotransporters SLC15A3 SLC15A4 SLC15A1 SLC15A2 G0 AND EARLY G1%REACTOME%R-HSA-1538133.3 G0 and Early G1 RBL2 RBL1 HDAC1 MAX E2F4 E2F5 DYRK1A E2F1 CCNA2 TOP2A CCNA1 PCNA TFDP1 CCNE2 TFDP2 CCNE1 CDK2 RBBP4 CDC6 MYC CDC25A LIN54 MYBL2 LIN52 CDK1 LIN37 LIN9 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 80%9678110 Attachment and Entry VCP CTSL TMPRSS2 ACE2 DEFECTIVE PYROPTOSIS%REACTOME DATABASE ID RELEASE 80%9710421 Defective pyroptosis DNMT3A H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L DNMT3B H2BC21 EZH2 H2BU1 H2AC8 PRIM2 H3C15 H2AC6 H2AC7 PRIM1 H2BC17 H2BC12 H2BC13 DNMT1 H2BC14 H2AJ SUZ12 H2BC15 H2BC11 RBBP4 RBBP7 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 POLA1 POLA2 H2BC5 H2BC3 GSDME H2BC1 H2AC20 EED H3C8 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 80%9007101 Rab regulation of trafficking ARF6 RAB4A GGA2 GGA1 RAB13 GGA3 CHML RIC1 TRAPPC10 AKT2 AKT1 RAB32 RAB35 RAB38 TSC2 RAB3A TSC1 RAB6B TRAPPC2 ALS2 TRAPPC3 ANKRD27 TRAPPC4 HPS1 TRAPPC5 HPS4 TRAPPC8 TRAPPC9 MAP1LC3B RAB31 RAB5B RAB5C SBF1 RAB6A RAB1A RAB1B DENND3 RAB21 TRAPPC1 SBF2 RAB12 GDI2 RINL TBC1D10A TBC1D10B RAB10 RAB7A RAB18 ULK1 RIN3 RIN1 RIN2 RAB39A RAB39B RAB27B TBC1D10C MON1A MON1B GDI1 RAB8B RAB33A RAB33B RAB7B RABGAP1 ALS2CL RAB11B RGP1 AKT3 RAB3GAP2 RAB3GAP1 DENND5B TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TRAPPC2L TBC1D20 TBC1D24 TBC1D25 DENND6B DENND6A RAB27A YWHAE TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 DENND4B DENND4A DENND4C CCZ1 RAB8A TBC1D2 TRAPPC6A RABEP1 TBC1D3 TRAPPC6B TBC1D7 OPTN RAB9A RAB9B RABGEF1 GABARAPL2 SYTL1 GAPVD1 GABARAP RAB5A RAB3IP CCZ1B RAB11A CHM DENND1C DENND1B DENND1A DENND2D DENND2C DENND2B DENND2A RAB3IL1 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.2 MAP2K and MAPK activation CNKSR1 FGB FGA TLN1 VWF RAF1 VCL IL17RD FGG YWHAB SRC NRAS HRAS MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 LAMTOR2 LAMTOR3 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 MAP2K2 KSR1 FN1 KSR2 WDR83 CNKSR2 APBB1IP DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 80%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.1 Regulation of HSF1-mediated heat shock response NUP62 NUP214 NDC1 HSPA5 SEC13 NUP210 HSPA6 HSPA1B HSPA1A NUP133 MAPKAPK2 NUP93 HIKESHI CCAR2 NUP50 DNAJC2 NUP54 DNAJC7 NUP205 POM121 RPS19BP1 HSPA4L AAAS HSPA14 HSPA13 NUP160 RPA2 DNAJB1 YWHAE BAG5 HSPH1 POM121C RPA3 DNAJB6 NUP42 MAPK1 BAG2 NUP85 BAG3 MAPK3 HSF1 TPR BAG1 NUP88 HSPA1L NUP43 HSPA4 RAE1 ST13 RANBP2 HSPA7 HSPA2 HSPA8 HSPA12A HSPA12B NUP155 RPA1 NUP153 ATM NUP35 NUP37 BAG4 SIRT1 HSPA9 ATR GSK3B NUP107 NUP188 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 80%5654706 FRS-mediated FGFR3 signaling FGF16 FGF18 NRAS SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF4 FGF9 FGF20 FGF23 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME%R-HSA-187024.2 NGF-independant TRKA activation NTRK1 NTRK2 ADORA2A ADCYAP1 ADCYAP1R1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 80%167243 Tat-mediated HIV elongation arrest and recovery ELOB ELOC TCEA1 SSRP1 CCNT1 POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE ELOA2 SUPT5H CDK9 ELL ELOA COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 80%1474290 Collagen formation BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LOXL3 LOXL4 CTSV CTSS MMP20 LOXL1 P4HB LOXL2 CTSL LOX CTSB MMP7 COL25A1 MMP3 MMP9 PLEC MMP13 ITGB4 COL15A1 P3H2 ITGA6 P3H1 LAMA3 P3H3 COL19A1 SERPINH1 PXDN COL26A1 LAMB3 PLOD3 PLOD2 COL11A1 PLOD1 COL11A2 TLL2 COL10A1 TLL1 COL28A1 COL27A1 COL24A1 PCOLCE COL22A1 COL1A1 COL3A1 COL2A1 PPIB CD151 COL1A2 COL4A2 CRTAP P4HA1 COL5A1 COL4A1 P4HA2 COL6A2 P4HA3 COL5A3 COLGALT2 COL4A4 COL7A1 COL5A2 COLGALT1 COL6A1 COL4A3 COL8A2 COL16A1 COL4A6 PCOLCE2 COL12A1 COL20A1 COL6A3 COL8A1 COL4A5 COL21A1 COL6A6 COL6A5 ADAMTS2 ADAMTS14 ADAMTS3 COL23A1 COL17A1 COL13A1 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%9037629 Lewis blood group biosynthesis ST3GAL6 ST6GALNAC6 FUT10 FUT11 B3GALT4 B3GALT5 ST3GAL4 FUT2 FUT4 FUT3 FUT6 ST3GAL3 FUT5 FUT7 FUT9 B3GALT2 B3GALT1 B4GALNT2 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.1 Regulation of PTEN mRNA translation TNRC6B AGO3 AGO4 AGO1 TNRC6C AGO2 MOV10 PTEN TNRC6A TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.2 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A4 SLC25A5 SLC28A2 SLC29A1 SLC28A1 ARL2 SLC25A4 SLC29A3 SLC25A6 ARL2BP SLC29A2 SLC28A3 PTEN REGULATION%REACTOME DATABASE ID RELEASE 80%6807070 PTEN Regulation BMI1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 RING1 PSMA5 PSMA6 HDAC2 PSMA3 RPTOR PSMA4 PSMA1 PSMA2 AKT2 PSME3 PSME4 MLST8 WWP2 PSME1 AKT1 PSME2 SLC38A9 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 RNF2 PSMA7 HDAC7 MTOR PSMB10 MAPK1 PSMA8 RRAGA PSMB6 MAPK3 RRAGC PSMB7 PSMB4 RHEB PSMB5 RRAGB PSMB2 PSMB3 RRAGD PSMB1 PSMF1 CBX8 LAMTOR2 PHC2 LAMTOR1 PHC1 PSMB8 LAMTOR4 PSMB9 LAMTOR3 LAMTOR5 CSNK2A1 CBX4 SEM1 PSMC5 CSNK2A2 CBX2 PSMC6 PSMC3 PSMC4 PSMC1 PHC3 PSMC2 PML CSNK2B HDAC3 HDAC1 ATF2 TRIM27 MKRN1 AKT3 EGR1 MOV10 SNAI1 SNAI2 EZH2 MECOM PPARG XIAP MBD3 SUZ12 USP7 GATAD2B JUN GATAD2A RNF146 TP53 NEDD4 FRK ATN1 SALL4 MAF1 TNKS AGO3 AGO4 CBX6 AGO1 AGO2 PTEN CHD4 CHD3 NR2E1 EED USP13 KDM1A HDAC5 MTA1 TNKS2 MTA2 MTA3 TNRC6C REST STUB1 TNRC6A OTUD3 TNRC6B PREX2 UBA52 UBB RBBP4 UBC RBBP7 RPS27A RCOR1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.3 Synthesis of IP3 and IP4 in the cytosol PLCB3 PLCB4 PLCB1 PLD4 PLCB2 INPP5D INPPL1 PLCG1 OCRL INPP5B PLCG2 SYNJ1 CALM1 INPP5J PLCZ1 PLCE1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PTEN ITPK1 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 80%8983711 OAS antiviral response FLNA ABCE1 PDE12 RNASEL DDX58 OAS1 OAS2 OAS3 OASL INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-HSA-912526.4 Interleukin receptor SHC signaling CSF2RB CSF2RA PIK3CD PIK3CB SHC1 INPP5D PIK3R3 GAB2 INPPL1 PIK3R1 PIK3CA SOS1 JAK3 CSF2 JAK1 PTPN6 IL5RA PIK3R2 IL2RG IL3RA IL2 IL3 IL2RA IL5 IL2RB JAK2 METABOLISM%REACTOME DATABASE ID RELEASE 80%1430728 Metabolism SUMO2 AOC1 NUP62 NUP214 NDC1 AGL PIAS4 SEC13 NUP210 NUP133 NUP93 HSD17B1 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 PFKL IMPDH1 IMPDH2 NUP35 NUP37 RARS1 KARS1 MARS1 PNLIP DARS1 MAOA AIMP1 MGST1 AIMP2 SARS1 EPRS1 INPP5D QARS1 PPA1 LARS1 IARS1 EEF1E1 GLIPR1 MANBA NME2 MTRR MMAA MMAB MTR ALDOC MMUT MMACHC ALDOA MMADHC LRP10 LRP12 CYP4V2 MAN2B1 SLC2A3 POLD1 NAPRT PPA2 BRIP1 PANK4 PANK2 IPPK PANK3 NUDT11 PANK1 NUDT10 COASY PPIP5K1 PPCDC PPIP5K2 SLC5A6 IP6K1 SLC25A16 NUDT3 VNN1 IP6K3 VNN2 NUDT4 PPCS PDZD11 FASN MT-CO1 ENPP2 ENPP1 ENPP3 GLS AASDHPPT COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 GNS SURF1 COX7B ERCC2 COX7C PIP4P1 COX8A ALAS1 COX5B COX5A PRKCA COX6C LRPPRC NRF1 PRKAA2 IDH2 PRKAG2 TACO1 GLUD1 GLUD2 COX6A1 STK11 AKT1 COX6B1 CYP17A1 PRKAB2 CYP19A1 GLO1 COX19 PDHB COX16 LDHC RPS6 COX18 LDHB LDHA PDPR MPC1 COX11 MPC2 COX14 PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 PDP1 PDP2 LDHAL6A LDHAL6B CYCS COX20 ALDOB DCXR COX4I1 GPX2 RRM2B ASNS GLS2 NDUFA4 TXNRD1 LBR GCKR OCRL PIK3R2 CPT1B TSPOAP1 SCD CAV1 ST3GAL6 ST6GALNAC6 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ESYT1 ENTPD5 CA2 ENTPD6 CA4 ENTPD7 ENTPD8 FUT10 FUT11 B3GALT4 B3GALT5 FUT2 FUT1 ABO FUT4 FUT3 FUT6 FUT5 FUT7 FUT9 B3GALT2 B3GALT1 B4GALNT2 MAN2B2 MAN2C1 PTGES3 GOT1 ADI1 PPP2R5D MRI1 ENOPH1 ACSL4 ACSL3 PPP2R1B SP1 GDA DNPH1 NT5C1B ITPA RGL1 ACOXL STARD5 SLC10A1 SLC10A2 SLC51A SLC51B ECHS1 ACADM HADH RPL4 RPL5 RPL30 ETFB RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 ACADVL RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 PM20D1 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 NUDT16 RPL27 NUDT5 RPL26 NUDT15 RPL29 ADPRM RPL28 RPS4Y2 LTC4S RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 HMMR RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 DIO1 DIO2 DIO3 PLCB3 PLCB4 PLCB1 PLCB2 CHST3 ACADL RTEL1 PRKG2 ODC1 AHR OAZ1 ARNT2 AHRR OAZ2 GLYCTK OAZ3 NQO1 AZIN1 CYP3A43 CYP2A7 ITPR1 CYP2A6 HMGCL ITPR2 POR ITPR3 ACSS3 CYP3A5 BDH2 CYP2C18 BDH1 LRP8 OXCT1 CYP3A7 OXCT2 CYP2B6 HMGCS2 CYP2A13 CYP2F1 HMGCLL1 AACS CYP4F12 CYP2W1 ACAT1 CYP2S1 NOS3 MIOX ISYNA1 INPP1 OSBPL9 MTMR9 OSBPL7 MTMR7 OSBPL6 INPP5B OSBPL3 INPP5A OSBPL2 IMPA1 CH25H SYNJ1 IMPA2 INPP5J IPMK MLXIPL CKMT2 GATM SLC6A8 CKM CKMT1B RHCE RHD GCHFR RAN ACY1 KPNB1 GCH1 PTS MVD GADL1 CSAD ADO MPST TSTD1 BHMT2 SQOR GOT2 SUOX BHMT TST ETHE1 CDO1 NSDHL STARD3 ACOT9 STARD4 MECR ACOT7 STARD6 ACOT1 HACD1 ABCB4 HACD3 HACD2 HACD4 HSD11B1 HSD11B2 FDFT1 MCAT SQLE PPT1 PPT2 ACOT7L SERPINA6 TSPO ELOVL4 ELOVL6 ELOVL7 PTGIS ACSBG1 CYP8B1 ACSBG2 EHHADH ACOT6 SC5D DECR2 GC G0S2 ACOT4 TM7SF2 SLC27A3 INSIG2 HSD3B7 INSIG1 ACAT2 AKR1C1 PMVK AKR1D1 THEM5 AKR1C3 NR1H4 SRD5A2 SRD5A1 AKR1C2 AKR1C4 DHCR24 RAB5A CYP7B1 TECRL ABCB11 DHCR7 SLC25A1 BAAT CYP7A1 FHL2 GGPS1 CYP27A1 HMGCS1 AMACR TNFRSF21 ACOX2 SLC27A5 HSD17B14 HSD17B13 COMT HSD17B12 HSD17B11 SLC25A20 MID1IP1 ECI1 ACAD11 ACAD10 ACSL6 ACSL5 PLPP6 PEX11A SCAP HTD2 DECR1 ITPK1 CIDEA CIDEC STAR AKR1B15 HILPDA TECR ARV1 ANKRD1 STARD3NL HSD17B3 FITM1 FITM2 HSD17B7 HSD17B8 HSD17B2 CBR4 OLAH GRHL1 RXRB NDUFAB1 UGT1A3 ACAA2 MSMO1 ACOT11 ACOT12 ACOT13 IDI1 IDI2 EBP MORC2 ACBD7 FDPS ACBD6 ACBD4 ACSF3 ACSF2 DBI CPT2 LSS MVK THRSP OAT PYCR1 PYCR2 PYCR3 KCNJ11 KYAT1 ABCC8 RIMKLA RIMKLB VKORC1L1 UBIAD1 COQ9 COQ7 COQ6 COQ5 COQ3 VKORC1 PDSS2 PDSS1 ABCG2 ALOX12 HK1 PIK3CG PIK3R5 LDLRAP1 AWAT1 DHRS7B CUBN AGPS AMN FAR1 FAR2 CES3 SAR1B LDLR ABCA1 NR1H2 VDAC1 NR1H3 FMO1 FMO2 FMO3 GLTP CERK HEXB HEXA GBA3 GBA2 SMPD3 SMPD2 STS SPTLC1 SMPD4 GM2A SPTLC2 SPTLC3 SMPD1 OSBP ENPP7 CERS3 CERS4 ARSA CERS5 CERS6 SPHK2 SPNS2 SUMF2 SUMF1 PRKD3 CPTP PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 CERS1 CSNK1G2 CERS2 ASAH1 SAMD8 ASAH2 PPM1L SGMS1 SGMS2 NEU2 BMX UGCG UGT8 NEU3 ALDH3B2 SGPL1 APIP ARSL ALDH3B1 ARSJ ORMDL2 NEU1 ARSK ORMDL3 PSAP ARSH ARSI ARSF B4GALNT1 SPTSSB ARSG KDSR SPTSSA ARSD ARSB CRYL1 CTSA XYLB B3GALNT1 ORMDL1 SGPP2 SGPP1 GALC ACER2 NFYA FA2H NFYB ACER1 GLB1L VAPA NFYC GLB1 VAPB ACER3 ESYT3 ESYT2 DEGS1 DEGS2 HSD17B10 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 NNT IDH3B ME3 ME2 IDH3A SDHC SDHD SDHA SDHB SUCLG2 SUCLG1 L2HGDH FH D2HGDH FAHD1 B4GALT1 MDH2 ADHFE1 SUCLA2 INS ADIPOR1 ADIPOR2 ALAS2 FECH COX15 UROS CPOX PPOX UROD HMBS COX10 SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLCO1B1 SLC25A15 ARG2 SLC25A2 CPS1 SLCO1B3 ASL NAGS NMRAL1 ASS1 SLCO1A2 GCDH HYKK AADAT OGDH PIPOX DLST SLC25A21 CRYM ALDH7A1 DLD AASS CKB MARCKS PTPN13 EPM2A GBE1 GAA G6PC1 TRMT112 GYS2 GYS1 G6PC3 PPP1R3C NHLRC1 GYG2 SLC37A4 GYG1 ABCB7 SLC9A1 PLCG2 GPT UCKL1 UCK2 UCK1 PUDP TK2 SLC5A8 SLC26A2 SLC6A12 SLC26A1 SLC6A11 SLC5A5 SLC6A7 SLC7A5 SLC25A10 SLC3A2 SLC36A4 MTMR1 SHMT2 IQGAP1 SORD AKR1B1 NAT1 NAT2 ACSM3 HMOX2 ACSM6 ACADS TPH2 DDC TPH1 AANAT ASMT PLIN3 RAB4A ALDH2 PFKFB2 PFKFB1 PFKFB4 PFKFB3 MINPP1 DUOX1 TPO IYD DUOX2 CMBL PPP1CC ALDH3A1 MAOB MTARC2 MTARC1 EPHX1 BPHL CBR3 CYB5B AOC3 NQO2 AOC2 AADAC ENO2 ENO3 PGK2 PCK2 PAPSS1 SLC37A1 TPI1 MDH1 PGAM2 G6PC2 GAPDH SLC25A11 FBP1 FBP2 KCNG2 DMGDH CHDH SARDH PNMT TH DBH QDPR IL4I1 HGD TAT PCBD1 FAH HPD ASRGL1 KCNC2 SYT5 MLX INMT PLCZ1 PLCE1 ITPKB ITPKC PIK3C3 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 SDS TMEM126B CIAO3 CIAO1 AFMID KCNB1 RIDA CIAPIN1 SMS UQCRH NDOR1 AMDHD1 UQCRQ KCNS3 NDUFA5 MT-CYB ETFA CARNMT1 GALE SRM UROC1 SLC45A2 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 TIAM2 NDUFAF2 KYAT3 NDUFAF3 NDUFAF1 ACY3 AKR7A2 AKR7A3 KMO NDUFB10 NDUFB11 PIK3R4 CA3 PIK3R3 B4GAT1 CA7 CA6 NAT8L TDH LIPT2 LIPT1 SDSL SAT1 ACMSD PAOX LHPP MMS19 COQ10B COQ10A AGMAT PGP COA1 ADPGK AMD1 FTCD WASL BPGM ISCA2 FFAR1 ISCA1 CIAO2B LIAS TYR HAL HDC HAAO NDUFA13 NCOA2 NDUFA11 NDUFA12 FOLH1B NDUFA10 GRHPR HK2 DCT ETFDH MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 TDO2 UQCRC1 UQCRC2 MTF1 IDO2 IDO1 CARNS1 LYRM4 NDUFC1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 SLC25A28 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 AKR7L SLC25A37 NUBP1 NUBP2 GCAT ACAD9 NUBPL NDUFV3 NDUFV2 NDUFV1 UQCRFS1 GLRX5 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 GLDC GCSH HOGA1 TMEM186 OCA2 TIMMDC1 AMT ASPG ASPA TYRP1 PFKM PFKP NAALAD2 TRAP1 UQCR11 UQCR10 CA12 CA14 CA13 FOLH1 AZIN2 DHTKD1 CA5B CA5A KYNU LALBA GNPDA1 ACBD5 GNPDA2 GSTM1 TPMT ABCC5 GMPS NME1 GUK1 GSTA1 DBT TXN2 NDUFS3 GCLC GCLM ME1 ABCC1 GPX1 BLVRB BLVRA GSTA3 DHFR TK1 TYMS RRM2 CHRM3 ADRA2C ADRA2A PAH ADSL CAD PAICS PFAS DHODH ATIC PPAT ADSS1 ADSS2 UMPS GART TGS1 CACNA2D2 FADS2 ELOVL1 ACOT8 SCP2 ACSL1 ELOVL5 ELOVL2 ELOVL3 HSD17B4 ACAA1 ABCD1 FADS1 UGT1A10 ACSM5 ACSM4 CYP2D6 GGT1 SULT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 CYP2E1 CES2 CES1 GSTT1 GLYAT CYP2C19 SULT1A1 UGT3A2 UGT3A1 SULT1A4 SULT1A3 GGT5 GLYATL3 GLYATL2 GGT7 GLYATL1 CYP26C1 GGT6 KHK CYP2C9 CYP2C8 ACSM2A ACSM2B UGT2A3 UGT2A2 UGT2A1 SULT1C4 ABCC3 UGT1A1 UGT2B4 UGT2B7 PON3 ADH1A PON1 UGT2B28 CYP3A4 NT5C2 SULT1E1 UGT1A5 UGT1A9 UGT1A8 UGT1A7 UGT1A6 SLC16A1 GGT3P PGK1 ENO1 N6AMT1 ACSM1 HPGDS AS3MT ABHD10 CHAC2 CHAC1 GSTK1 MAT1A TPST2 TPST1 SULT6B1 NNMT MGST3 MGST2 GSTT2 ESD GSTT2B SULT1A2 GSTM4 GSTM3 GSTM2 GGCT SULT1B1 CYP1A2 GSTM5 PODXL2 OPLAH SULT1C2 SULT4A1 GSTO2 AKR1A1 ABHD14B UGDH AHCY MAT2B PAPSS2 UGP2 MAT2A BPNT2 BPNT1 GSTZ1 GSTA5 GSTA4 PECR NUDT19 PHYH ACOT2 ATP5MC1 INPP5E VAC14 PI4K2B MTMR10 MTMR2 HACL1 MTMR12 HAO1 MTMR4 CYC1 PIK3C2A HAO2 MTM1 INPP4A FIG4 INPP4B EPHX2 PIKFYVE INPP5F PI4K2A CS COQ2 DAO PXMP2 PIK3CD ACO2 PIK3CB HSCB CROT GK3P SLC25A17 MOGAT3 MOGAT2 MOGAT1 ABHD5 ACOX3 FABP12 GK2 SLC25A12 AGXT LIPE AGMO FXN GK SLC25A13 FABP9 NDUFB8 PPP1CA FABP1 FABP2 FABP3 DDO FABP4 FABP5 ATP5F1A FABP6 ATP5F1B FABP7 PNPLA4 PNPLA5 PLIN1 IDH3G NUDT7 CRAT OTC GPX4 ALOX15B CARM1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP HPRT1 ADA LYPLA1 NOSIP ZDHHC21 CYGB DDAH1 SPR DDAH2 NOSTRIN RAP1A GALT SRD5A3 GALK1 HPSE2 XYLT2 XYLT1 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 NAGLU NDST4 NDST3 IDS GUSB HS3ST3B1 GLCE B4GALT7 HS3ST3A1 IDUA B3GAT3 B3GAT2 NT5C B3GAT1 AGXT2 HS3ST5 HS3ST6 NT5C1A DPYS HS3ST4 DPYD HS3ST1 HS3ST2 UPP2 EXT1 NT5M EXT2 UPP1 HPSE UPB1 TYMP PTGS1 SACM1L SBF1 ARF3 TNFAIP8 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 TPTE2 RUFY1 MTMR3 MTMR8 GDPD1 GDPD3 TPTE GDPD5 PIK3R6 MTMR6 INPP5K PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 SYNJ2 PLEKHA8 PI4KB PNPLA6 CYP11A1 FDX1 FDX2 FDXR TTPA HSD3B2 CYP11B2 CYP21A2 HSD3B1 BST1 SLC25A27 UCP3 UCP2 UCP1 SLC25A14 FOLR2 AHCYL1 PIP4K2A PIP4K2B PIP4K2C TRIB3 PIP5K1A PIP5K1B PIP5K1C PPARG SLC16A8 SLC16A3 PPARGC1B ESRRA THEM4 PTEN CHST14 CHSY1 PLIN2 CBS CTH SCLY HNMT GNMT ARF1 CA1 BCKDHA MCCC2 ACAD8 HIBADH MCCC1 BCKDHB PPM1K ACADSB BCKDK ALDH6A1 GSTO1 AUH IVD AIP BCAT1 SLC25A44 HIBCH BCAT2 MTAP GSTA2 ABCC2 ALOX5 DTYMK AK1 AK2 AK4 GLRX AK5 CYP1B1 AK6 AK7 AK8 AK9 NME2P1 NUDT13 RRM1 NME3 CTPS2 NME4 CTPS1 DCTD CMPK1 DCTPP1 RXRA ARNT CA9 PPARGC1A MED19 GLUL MED16 MED15 MED18 MED17 MED12 MED11 MED14 MED13 MED10 MED27 MED26 MED29 MED28 MED23 MED22 MED25 MED24 MED21 MED20 PPARA ADIPOQ MED30 MED31 PC BTD PCCA HLCS PCCB ACACB ACACA CYP46A1 CYP39A1 CCNC SLC22A5 THTPA TPK1 SLC25A19 SLC19A3 SLC19A2 STAB2 TMLHE STX1A SHMT1 BBOX1 ALDH9A1 PCK1 MED13L CD36 NCOA1 NCOA6 NCOA3 SREBF2 GCK CACNA1D CACNA1C CHD9 LRP1 LRP2 MED1 MED8 MED9 MED4 MED6 MED7 CDK19 CACNB2 CACNB3 CDK8 SMARCD3 CYP51A1 PTGDS HELZ2 AGT AKAP5 SCD5 SLC2A2 GAMT DNM2 THRAP3 DMAC2L ATP5PF ATP5PD ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATP5F1D ATP5F1E MT-ATP8 MT-ATP6 FAM120B ATP5PO ATP5MG ATP5MF ATP5ME CYP11B1 CYSLTR2 SLC23A2 SLC46A1 ALDH1L1 LHB DHFR2 SLC23A1 NADSYN1 ALDH1L2 FLAD1 NUDT12 MTHFD1 MTHFD2 MTHFD2L PNPO NADK CGA SLC19A1 CBLIF SLC52A2 SLC52A3 MTHFR SLC52A1 MTHFS TCN2 GLP1R CD320 ABCD4 MOCS2 MOCS3 QPRT GPHN NADK2 SLC22A13 NMRK2 RFK TSHB NMRK1 ACP5 CD38 AOX1 LMBRD1 NAXE MTHFD1L CYB5A RNLS MOCOS NMNAT3 NMNAT2 NMNAT1 SLC25A32 NAXD GNAI1 GNAI2 GCG POMC CHST6 LUM OGN OMD KERA PRELP FMOD CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP2R1 MCEE CHPF CHP1 CSGALNACT1 CSGALNACT2 CEMIP CHST11 CHST12 DSEL CHST15 CHST13 UST B4GALT2 CALM1 B4GALT3 HYAL1 HYAL2 HYAL3 DSE LPGAT1 CHST7 CPNE7 CHPF2 PITPNB CPNE6 B3GNT7 LCLAT1 B3GNT4 PLB1 B3GNT3 CHST1 LIPI LIPH B3GNT2 CPNE1 B4GALT6 CHST5 CPNE3 MFSD2A B4GALT4 CHST2 PCYT2 DGAT2 B4GALT5 MIGA2 HAS1 MIGA1 HAS3 DGAT1 HAS2 CHSY3 CSNK2A1 STARD7 LYVE1 CSNK2A2 PISD PLA2G15 GNPAT PHOSPHO1 GPD2 PLA2G10 GPD1 CSNK2B PLBD1 PLA2R1 PLA1A CDS1 ABHD4 ABHD3 CHAT PLA2G3 PLD4 PLD6 PLA2G5 PLA2G6 PLD1 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 CHKB TMEM86B OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT ALPI CDS2 SLC44A5 ACHE SLC44A3 SLC44A4 SLC44A1 SLC44A2 ALDH4A1 LPCAT1 PCTP PRODH OSBPL10 PRODH2 ACP6 PCYT1B PLA2G4F PLA2G12A PCYT1A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLAAT2 GPCPD1 PLAAT5 PLAAT4 HADHB HADHA PITPNM1 PITPNM3 PITPNM2 MGLL AGPAT5 TAFAZZIN PLA2G1B AGPAT1 AGPAT2 SELENOI AGPAT3 AGPAT4 AWAT2 GPAT4 FAAH CYP4A22 GPAT3 CBR1 CEPT1 CYP4A11 GPAT2 FAAH2 CDIPT PTGR1 PLA2G2F BCHE PTGR2 CYP2U1 PLA2G2D DPEP2 PLA2G2E DPEP1 AGK PNPLA8 DPEP3 MBOAT7 PTGES PLA2G2A HPGD MBOAT1 PON2 DDHD2 ALOX12B MBOAT2 CYP4F22 ALOXE3 DDHD1 CYP2J2 ETNPPL CYP4F2 GPAM CYP4F3 ETNK2 CYP4B1 LPCAT4 CYP4F8 ETNK1 LPCAT3 CYP4F11 PRXL2B LPCAT2 PNPLA3 ALOX5AP TBXAS1 CHPT1 GPD1L CYP1A1 LPIN1 LPIN2 LPIN3 PNPLA2 PPP1CB PPP2R1A PRKACA STXBP1 HSP90AA1 RORA NAMPT SREBF1 CPT1A CLOCK NPAS2 UBA52 ARNTL CACNA1A CACNA1E NR1D1 GSS UBB PRKAR2B UBC RPS27A PYGM PHKB PHKA1 PHKA2 PGM2L1 PHKG1 PHKG2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 LTA4H PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 LGMN PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 RAPGEF3 RAPGEF4 PSMB10 GSTP1 PSMA8 PSMB6 PSMB7 PPARD PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ACLY NCOR2 HDAC3 NCOR1 SLC27A2 TBL1XR1 SIN3A GPS2 TBL1X IP6K2 PIK3R1 OSBPL1A SNAP25 PIK3CA PLCG1 PRSS1 ALAD PGM1 BSG PHYKPL CTRB2 CTRB1 HSPG2 BCAN DCN CD44 ACAN VDR INPPL1 CDA PRSS3 HMOX1 TCN1 GPI PYGB TTR PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PRKAR2A GNAS ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CREBBP EP300 PTGES2 SEPHS2 PSTK SECISBP2 EEFSEC SEPSECS ADH4 ACSS2 ALDH1B1 ADH1C ALOX15 ADH1B ALDH1A1 ACSS1 ADH7 ADH5 IDH1 ADH6 HK3 UBE2I PDXK HSP90AB1 CYB5R3 TKFC ECSIT ARG1 PGAM1 LRAT VAMP2 PTGS2 RBP4 CLPS RBP2 RBP1 RETSAT MAPKAPK2 RDH11 SLC2A1 PPP2CA PPP2CB NDUFC2 SEC23A SRR PSAT1 PHGDH SERINC1 SERINC3 SERINC2 SERINC5 PSPH SERINC4 SEC24B SEC24A PRPS2 PRPS1 SEC24D G6PD RPEL1 SEC24C RPE TALDO1 PGD DERA RPIA SHPK PGM2 PGLS PRPS1L1 TKT RBKS SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 GPC5 CSPG4 GPC4 AGRN GPC6 XDH LPL APOE APOB GPIHBP1 MBTPS1 APOA2 APOC3 APOA1 APOA4 APOA5 APOC2 ALB ANGPTL4 MBTPS2 BCO2 BCO1 GAPDHS GNG10 GNG12 GNG11 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 SAMHD1 GBA GNA14 GNA15 GNG3 GNG2 GNG5 GNG4 APOM GNA11 GNG7 GNG8 UGT1A4 AKR1B10 NUP107 NUP188 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.1 The citric acid (TCA) cycle and respiratory electron transport PM20D1 COX6C LRPPRC IDH2 NDUFAB1 TACO1 COX6A1 COX6B1 GLO1 COX19 PDHB COX16 LDHC COX18 LDHB LDHA NDUFC2 PDPR MPC1 MPC2 COX11 SLC16A1 PDK4 COX14 PDK3 NDUFS3 DLAT PDK2 PPARD PDK1 PDHX PDHA2 PDHA1 PDP1 PDP2 LDHAL6A LDHAL6B OGDH CYCS ME1 DLST COX20 DLD COX4I1 RXRA NDUFA4 GSTZ1 VDAC1 BSG TMEM126B SLC25A27 ATP5MC1 UCP3 UCP2 UCP1 SLC25A14 UQCRH DMAC2L CYC1 UQCRQ ATP5PF NDUFA5 MT-CYB ATP5PD ETFA ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATP5F1D NDUFAF6 ATP5F1E NDUFAF7 MT-ATP8 NDUFAF4 MT-ATP6 CS NDUFAF5 ATP5PO ATP5MG NDUFAF2 ATP5MF ATP5ME NDUFAF3 NDUFAF1 ACO2 NDUFB10 NDUFB11 SLC16A8 COQ10B COQ10A SLC16A3 COA1 NDUFB8 ATP5F1A NDUFA13 ATP5F1B NDUFA11 NDUFA12 NDUFA10 ETFDH IDH3G MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 UQCRC1 UQCRC2 NDUFC1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 ACAD9 MT-CO1 NUBPL NDUFV3 NDUFV2 NDUFV1 UQCRFS1 COX7A2L NDUFS8 SCO1 NDUFS7 SCO2 NDUFS6 NDUFS5 MT-CO2 NNT NDUFS4 MT-CO3 IDH3B NDUFS2 ME3 NDUFS1 ME2 IDH3A SDHC SDHD TMEM186 SDHA ETFB SDHB TIMMDC1 SUCLG2 SUCLG1 SURF1 L2HGDH FH ECSIT D2HGDH FAHD1 MDH2 TRAP1 ADHFE1 COX7B UQCR11 SUCLA2 UQCR10 COX7C COX8A COX5B COX5A AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 80%174084 Autodegradation of Cdh1 by Cdh1:APC C ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 UBB UBC RPS27A UBE2D1 ANAPC15 ANAPC16 ANAPC10 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 80%169131 Inhibition of PKR EIF2AK2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 80%418990 Adherens junctions interactions CDH6 CDH5 CDH3 CDH24 CADM3 CTNNA1 CADM1 CADM2 CDH10 CDH11 CDH12 CDH13 ANG NECTIN4 CDH17 NECTIN3 CDH18 NECTIN1 CDH4 CDH2 CDH1 PVR CTNNB1 NECTIN2 JUP CTNND1 CDH15 CDH9 CDH8 CDH7 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 80%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 CCNE1 RB1 CDK2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 80%168138 Toll Like Receptor 9 (TLR9) Cascade IKBKB RPS6KA2 RPS6KA1 RBSN ATF1 IKBKG PIK3R4 MAP3K7 MAP2K6 TICAM2 CHUK TLR9 MAPKAPK3 MAPKAPK2 TLR7 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A LY96 CD14 DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N TLR4 MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 TICAM1 CUL1 ELK1 CREB1 UBB MAP2K1 IRF7 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER PIK3C3 S100A12 ECSIT EEA1 MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.2 Signaling by Leptin LEP SOCS3 IRS1 IRS2 STAT5A STAT3 STAT5B PTPN11 JAK2 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.6 Membrane Trafficking SEC13 GRIA1 LNPEP CALM1 AVP SBF1 ARF3 PLA2G6 SBF2 CPD GDI2 BTC PICALM HBEGF SYNJ2 EREG PLA2G4A AGPAT3 PIP5K1C AKT3 YWHAE ACTR1A GRK2 RAB8A YWHAG CSNK1D GOLGA2 ITSN2 CUX1 DYNLL1 ITSN1 FNBP1L UBA52 GJA1 OPTN PAFAH1B1 FNBP1 DYNC1I2 DCTN2 DCTN3 ARF1 RALA DYNC1LI1 DYNC1LI2 UBB UBC GNS RPS27A DYNC1H1 MYO6 SFN VAMP7 CHM WNT5A ARPC1A FZD4 DYNLL2 NSF C2CD5 PLIN3 RALGAPA2 TBC1D1 GPS1 RALGAPB TBC1D4 PRKAA2 STXBP3 RAB4A ASPSCR1 RAB13 YWHAB PRKAG1 PRKAG2 PRKAG3 STX5 AKT2 AKT1 PRKAB2 TSC2 TSC1 PRKAB1 PAFAH1B2 STX4 AP3B1 RHOBTB3 TFRC SNAP23 DVL2 FTL ARPC4 ARPC5 COPS4 TXNDC5 ARPC2 EGF ARPC3 COPS2 CBL EGFR OCRL TMED2 ACTR3 ACTR2 SNAP29 ARFGAP3 RAB7A VAMP3 ARFGAP2 LMAN1 SYT1 RACGAP1 MYO1C YKT6 ZW10 CFTR SH3GL3 SCFD1 SPTBN1 CLTCL1 STAM WASL RAB27A MYO5A SPTAN1 SPTB CTTN RHOQ ARF4 ANK2 DYNC1I1 ANK3 TGOLN2 ACTR10 F5 TRIP10 EXOC8 RAB9A EXOC7 RAB9B F8 TF USP6NL SCOC RABGEF1 EXOC4 GJA3 EXOC3 MIA3 TFG EXOC6 GJA5 EXOC5 GJA4 EXOC2 GJA9 GJA8 EXOC1 GABARAPL2 SYTL1 GAPVD1 BIN1 IGF2R AGTR1 IL7R GABARAP GJC1 GJC2 VTI1A RAB3IP STAM2 GBF1 CCZ1B RAB11A GJB4 GJB3 GJB6 GJB5 GJB7 DENND1C DENND1B DENND1A STON1 STON2 SLC18A3 DENND2D DENND2C DENND2B DENND2A AP1S2 COPZ2 AP1S1 RAB3IL1 AP1S3 TACR1 EPS15L1 COPZ1 GJD2 GJD4 GJD3 VAMP4 PAFAH1B3 ARF5 SH3GL2 ARF6 NBAS NEDD8 TMF1 USO1 GGA2 ARFRP1 GGA1 GGA3 LMAN2 STX6 YWHAQ CHML RIC1 TRAPPC10 ARCN1 YWHAH SNX18 GOLIM4 RAB43 RAB41 SPTA1 RAB32 RINT1 RAB30 RAB36 RAB35 RAB38 YWHAZ ARL1 RAB3A RAB6B KIAA0319 TRAPPC2 ALS2 SEC16B TRAPPC3 TOR1A ANKRD27 TRAPPC4 SEC16A HPS1 TRAPPC5 HPS4 TRAPPC8 TRAPPC9 TOR1B MAP1LC3B DAB2 CNIH1 AAK1 CNIH2 CNIH3 RAB31 MCFD2 BICD1 BICD2 RAB5B PPP6R1 RAB5C SGIP1 BET1L ARFGAP1 SEC22A RAB6A SEC22C RAB1A AP1M2 RAB1B AP1M1 PPP6C DENND3 LRP2 PPP6R3 RAB21 TRAPPC1 VPS51 FCHO1 VPS53 VPS52 FCHO2 UBQLN1 VPS54 UBQLN2 AP1G1 NECAP2 SYT11 RAB12 FOLR1 BET1 KDELR1 COL7A1 GCC2 GCC1 GOLGA5 RINL GOLGA1 ARFIP2 TBC1D10A AGFG1 RAB10 TBC1D10B COG8 COG7 COG6 LMAN1L COG5 RAB18 COG4 GJB2 COG3 GJB1 COG2 COG1 CHRM2 ANKRD28 PREB ULK1 RIN3 KDELR2 KDELR3 RIN1 RIN2 LMAN2L KIF3A GJA10 RAB39A ADRB2 RAB39B FTH1 RAB27B TBC1D10C SNAP91 MON1A MON1B HIP1 GDI1 AP1B1 MIA2 TMED3 TMED7 RAB8B TMED9 RAB33A RAB33B CLTB RAB7B NAPB RABGAP1 STX17 STX16 STX18 NAPG STX10 ALS2CL EPS15 RAB11B RGP1 SEC23IP RAB3GAP2 TRIP11 COPG2 COPG1 RAB3GAP1 SCARB2 SYS1 DENND5B TRAPPC12 TRAPPC11 DENND5A TRAPPC13 SH3GL1 TRAPPC2L TBC1D20 TBC1D24 CAPZA3 TBC1D25 DENND6B SYNJ1 AMPH DENND6A COPB2 COPA TMED10 MAN2A2 TBC1D13 PACSIN2 TBC1D14 COPB1 PACSIN3 TBC1D17 TBC1D15 TBC1D16 PACSIN1 SYT2 CD4 DENND4B DENND4A DENND4C CCZ1 SYT9 SYT8 TMEM115 ALPP KIF28P COPE USE1 RABEPK SLC2A8 KIF5C MAN1A2 KIF5B MAN1A1 KIF5A NAA30 EPN1 KIF21A EPN2 KIF21B TBC1D2 APP KIFAP3 TRAPPC6A RABEP1 KIF16B TBC1D3 KIF20A TRAPPC6B KIF20B GORASP1 TBC1D7 NAA35 NAA38 GOSR2 GOSR1 COPS7B CYTH3 COPS7A CYTH2 KLC1 CYTH4 BNIP1 MAN1C1 COPS3 REPS2 KLC4 COPS6 CYTH1 KLC3 COPS5 REPS1 KLC2 COPS8 GALNT2 KIF3B KIF3C GOLGA4 KIF18A KIF18B KIF4B KIF4A RAB5A GALNT1 KIF12 TSG101 VPS4B KIF11 VPS4A KIF15 MVB12B VAMP2 MVB12A VPS36 KIF19 CAPZB VTA1 VPS37C KIF13B VPS37D KIF1C VPS37A SPTBN4 SNF8 KIF1B VPS37B SPTBN5 KIF1A CHMP2B CHMP4C KIF25 CHMP2A KIF23 CHMP4B KIF22 CHMP3 UBAP1 KIF6 CHMP4A KIF27 CHMP6 CHMP7 VPS25 KIF9 VPS28 KIFC2 CHMP5 SPTBN2 KIF2A KIFC1 KIF2C KIF2B SH3KBP1 CENPE KIF26A CAPZA1 KIF26B CAPZA2 VPS45 SEC22B SEC23A HGS SEC24B SEC24A SEC24D SEC24C CLTC CLTA RAC1 LDLRAP1 SEC31A SURF4 SAR1B LDLR CTSZ CD3G CD3D SLC2A4 MYH9 CTSC DNM1 DNM2 DNM3 PIK3C2A APOB AREG TGFA CD59 CD55 EPGN TJP1 GRK3 HSPA8 ANK1 AVPR2 AP4E1 DCTN6 CLINT1 DCTN5 AP4M1 DCTN1 AP1G2 AP3S1 DCTN4 SH3D19 TPD52 GAK DNAJC6 MAN2A1 DNASE2 NAPA BLOC1S4 BLOC1S6 SNX2 BLOC1S1 BLOC1S3 CLVS2 AP4S1 SNX9 SNX5 CLVS1 TBC1D8B SNAPIN SORT1 M6PR DTNBP1 HIP1R PUM1 TPD52L1 AP4B1 NECAP1 GOLGB1 YIPF6 ACBD3 AP2S1 AP2A1 SERPINA1 AP2B1 AP2A2 INS AP2M1 ARRB1 ARRB2 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 80%9007892 Interleukin-38 signaling MAPK8 IL1RAPL1 IL1RL2 IL1F10 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.6 Synthesis of PIPs at the late endosome membrane VAC14 MTMR2 PIK3C3 MTMR4 MTMR9 PIK3C2A MTM1 MTMR7 FIG4 PIK3R4 PIKFYVE DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME%R-HSA-5578998.2 Defective OPLAH causes OPLAHD OPLAH HDL REMODELING%REACTOME%R-HSA-8964058.2 HDL remodeling ABCG1 CETP LCAT APOC3 APOA1 APOC2 ALB LIPG APOE DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 80%5687613 Diseases associated with surfactant metabolism SFTA3 CSF2RB SFTPB CSF2RA SLC34A2 SFTPC SFTPD SFTPA2 SFTPA1 ABCA3 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 80%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.1 RUNX3 regulates RUNX1-mediated transcription CBFB RUNX3 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.1 SARS-CoV-2 modulates autophagy VPS11 VPS16 VPS33A VPS33B VPS41 VPS39 TUFM UVRAG VPS18 MAP1LC3B VPS45 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.2 Amino acids regulate mTORC1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 SEC13 RPTOR SESN2 MLST8 SLC38A9 MTOR SESN1 RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SZT2 SEH1L NPRL2 NPRL3 WDR59 FLCN MIOS ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 FNIP2 KICS2 CASTOR1 CASTOR2 BMT2 ATP6V1H ATP6V1A TCIRG1 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 80%400451 Free fatty acids regulate insulin secretion ACSL4 PLCB3 GNAQ ACSL3 GNA14 PLCB1 PLCB2 GNA15 CD36 GNA11 FFAR1 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 80%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 RHO GTPASES ACTIVATE PAKS%REACTOME%R-HSA-5627123.2 RHO GTPases activate PAKs CDC42 PAK1 PPP1CB PPP1R12B RAC1 PAK3 MYLK PAK2 NF2 MYL12B MYH9 CTTN FLNA MYH14 LIMK1 MYH11 PPP1R12A MYH10 MYL6 CALM1 MYL9 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 80%2122948 Activated NOTCH1 Transmits Signal to the Nucleus ITCH NOTCH1 UBA52 DNER DTX1 DTX2 DTX4 DLK1 UBB UBC RPS27A CNTN1 APH1A PSENEN APH1B PSEN2 JAG2 ADAM10 MIB2 DLL1 MIB1 ADAM17 DLL4 NEURL1B NEURL1 ARRB1 ARRB2 PSEN1 JAG1 NCSTN NUMB DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 80%9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function CDKN2A C1QBP NADPH REGENERATION%REACTOME DATABASE ID RELEASE 80%389542 NADPH regeneration IDH1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.2 Regulation of cholesterol biosynthesis by SREBP (SREBF) HELZ2 MBTPS1 CREBBP MBTPS2 GPAM IDI1 FDPS LSS MVK SEC23A NCOA2 CHD9 RAN KPNB1 MVD SEC24B SEC24A ACACB ACACA SEC24D SP1 RXRA SEC24C MTF1 NFYA NFYB NFYC TGS1 TBL1XR1 TBL1X FDFT1 SQLE SMARCD3 CARM1 FASN ELOVL6 SAR1B MED1 SC5D TM7SF2 INSIG2 INSIG1 CYP51A1 PMVK DHCR7 GGPS1 HMGCS1 NCOA1 NCOA6 SREBF2 PPARA SCAP SCD DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 80%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.2 RNA Polymerase III Transcription POLR3GL TBP POLR1C POLR1D SSB GTF3C1 NFIX GTF3C2 POLR2E POLR3A NFIA GTF3C3 POLR2F POLR3B NFIB GTF3C4 POLR3C NFIC GTF3C5 POLR2H POLR3D GTF3C6 POLR3E SNAPC5 SNAPC1 POLR2K POLR3F SNAPC2 POLR2L POLR3G SNAPC3 POLR3H SNAPC4 POLR3K ZNF143 BRF2 BRF1 GTF3A BDP1 POU2F1 CRCP SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.2 SHC-mediated cascade:FGFR3 SOS1 HRAS FGF1 FGF16 FGF2 FGF18 FGF4 FGF9 FGF20 NRAS FGF23 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 80%112310 Neurotransmitter release cycle RAB3A SLC22A2 SLC22A1 ABAT SLC6A13 ARL6IP5 SLC6A12 SLC6A11 HSPA8 SLC1A1 SLC6A1 SLC1A2 SLC1A3 SLC5A7 SLC1A6 SLC1A7 SLC18A2 SLC38A2 LIN7B GLS2 CHAT SLC32A1 ALDH5A1 MAOA NAAA SNAP25 STX1A DNAJC5 GLS SLC17A7 CASK LIN7A LIN7C APBA1 UNC13B SYT1 SYN3 CPLX1 SYN2 SYN1 RIMS1 PPFIA1 VAMP2 GAD1 PPFIA4 GAD2 TSPOAP1 PPFIA3 PPFIA2 SLC18A3 DNA REPAIR%REACTOME DATABASE ID RELEASE 80%73894 DNA Repair HERC2 SUMO3 PRKDC SUMO2 REV1 PIAS4 MAD2L2 REV3L POLI PARP1 FAAP100 ZNF830 PIAS1 NHEJ1 TDP2 RNF168 TDP1 FAAP24 FAAP20 DCLRE1B ALKBH2 DCLRE1A DCLRE1C ISY1 RIF1 HMGN1 BLM XPC FANCM PARG FANCL POLB APEX1 FANCA ADPRS MRE11 FANCB FANCE WRN FANCG FANCF UVSSA POLL FAN1 TDG POLN POLM NPLOC4 XRCC4 UBE2N UFD1 RPA1 RAD52 FEN1 TINF2 TERF1 TERF2 MSH6 UBE2V2 CCNA2 SIRT6 CCNA1 POT1 TERF2IP DNA2 RTEL1 MPG MGMT POLR2A POLR2B POLR2C POLR2D NSD2 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L ACD H3-4 RNF4 RCHY1 PCNA NTHL1 POLD3 POLD4 POLD1 POLD2 EP300 POLK POLE RFC5 RFC3 RFC4 LIG1 RFC1 TP53 RFC2 RPA2 XRCC1 LIG3 MAPK8 POLE4 CETN2 RPA3 KPNA2 MUS81 POLE2 EME1 POLE3 EME2 POLH GEN1 PIAS3 SLX1B SPIDR SLX4 XRCC3 BRCA2 RAD51AP1 BRIP1 KAT5 UBE2I EXO1 SUMO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 NFRKB RAD51D ACTR5 RAD50 ACTL6A RAD51 CCNH USP45 ACTR8 INO80C UBE2L6 INO80B INO80E INO80D COPS7B COPS7A TFPT MCRS1 UBA52 INO80 COPS3 COPS6 COPS5 TRIM25 COPS8 MSH3 ABL1 HUS1 UBB UBC RHNO1 CDK7 RPS27A UBA7 MNAT1 XPA PARP2 ATRIP GTF2H1 CHD1L USP10 PCLAF GTF2H2 GTF2H3 USP43 SPRTN GTF2H4 GTF2H5 RAD17 DDB2 CUL4A ATR DDB1 ERCC3 ELL ERCC4 ERCC1 ISG15 ERCC2 ERCC5 CUL4B RBX1 ERCC6 PMS2 RAD51B MLH1 RAD51C GPS1 TCEA1 RAD1 MSH2 CDK2 FANCD2 FANCI FANCC CHEK2 SEM1 NEIL3 RAD9B RAD9A ATM UBXN1 BABAM1 TOPBP1 BABAM2 UIMC1 BAZ1B ABRAXAS1 RNF8 BRCC3 APBB1 TP53BP1 KDM4A EYA1 EYA2 EYA3 EYA4 PPP5C COPS4 BAP1 COPS2 XRCC6 VCP XRCC5 RAD23A RAD23B POLQ ERCC8 OGG1 CHEK1 LIG4 YY1 ACTB USP7 CLSPN UBE2B UBE2T KDM4B H2AX H2AB1 H2AC19 H2AC14 H2BC12L PPP4R2 TIPIN H2BC21 RUVBL1 TIMELESS AQR PPP4C H2BU1 H2AC8 H2AC6 PAXIP1 H2AC7 H2BC17 H2BC12 PPIE H2BC13 PNKP MBD4 H2BC14 H2AJ SMUG1 NEIL2 H2BC15 NEIL1 H2BC11 WDR48 USP1 FTO ALKBH3 DTL ALKBH5 RAD18 H2AZ1 PRPF19 H2BC9 ASCC1 ASCC2 ASCC3 H2AZ2 H4C9 H2BC8 CENPX H2BC5 H2BC3 SMARCA5 H2BC1 H2AC20 XAB2 MDC1 CENPS RNF111 BRCA1 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 80%2023837 Signaling by FGFR2 amplification mutants FGFR2 SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.1 Signaling by RAS GTPase mutants KRAS HRAS NRAS DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 80%180024 DARPP-32 events PPP2CA PRKACG PPP1CA PPP2CB PRKACB PRKAR1B PRKAR1A PPP1R1B PPP3CB PPP2R1A PDE4B PRKAR2A PPP2R5D PRKACA PPP3CC PPP3CA PPP2R1B PDE4A PDE4D PPP3R1 PRKAR2B CALM1 PDE4C CDK5 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%191273 Cholesterol biosynthesis ARV1 SREBF1 HSD17B7 FDFT1 SQLE LBR MSMO1 IDI1 IDI2 EBP SC5D FDPS TM7SF2 CYP51A1 ACAT2 PMVK LSS MVK DHCR24 DHCR7 GGPS1 HMGCS1 MVD SREBF2 PLPP6 NSDHL MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 80%2206285 MPS VI - Maroteaux-Lamy syndrome ARSB IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 80%917937 Iron uptake and transport SLC11A2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 SLC40A1 HMOX1 NEDD8 CP LCN2 SLC22A17 FTMT SLC46A1 HFE STEAP2 GLRX3 SKP1 ABCG2 TFRC FBXL5 MCOLN1 FTL UBA52 TF STEAP3 CUL1 UBB UBC RPS27A TFR2 ATP6V1H ATP6V1A HMOX2 TCIRG1 FTH1 ATP6V0A2 HEPH ATP6V0A4 ATP6V1E1 CAND1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D IREB2 ATP6V1C1 ATP6V0A1 ATP6V1F ATP6V1C2 ATP6V1G1 CYBRD1 ATP6V0B ATP6V0E1 ACO1 ATP6V1G2 ATP6AP1 METHYLATION%REACTOME DATABASE ID RELEASE 80%156581 Methylation TPMT GSTO1 N6AMT1 AHCY MAT2B AS3MT MAT2A COMT MAT1A NNMT TRMT112 MTRR MTR CYP1A2 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 80%167172 Transcription of the HIV genome TAF9B ELOB ELOC TCEA1 CCNT2 CCNT1 SUPT16H GTF2F1 GTF2F2 ELOA2 GTF2B GTF2E1 CDK9 GTF2E2 RNMT RNGTT TAF4B GTF2A1 GTF2A2 TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP SSRP1 TAF7 TAF6 TAF5 TAF4 TAF3 CCNK TAF2 TAF1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 SUPT5H ERCC3 ELL ERCC2 TAF7L ELOA ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 80%9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CA EPO PIK3CD IRS2 PIK3CB EPOR LYN PIK3CG GAB1 PIK3R5 PIK3R1 JAK2 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 80%2028269 Signaling by Hippo DVL2 YWHAE WWC1 NPHP4 STK4 STK3 SAV1 YWHAB MOB1B LATS1 MOB1A LATS2 AMOTL2 CASP3 AMOTL1 YAP1 TJP1 WWTR1 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 80%9608287 Defective MUTYH substrate binding DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 80%3371598 Defective BTD causes biotidinase deficiency BTD GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 80%212436 Generic Transcription Pathway BMI1 KRAS KDM5B RING1 PARP1 HDAC11 HDAC9 BLM RNF2 HDAC7 WRN CSF1R CBX8 PHC2 PHC1 CBX4 CDKN2A CBX2 PCGF2 RPA1 BRD2 PHC3 PML ATF2 PIP4K2A PIP4K2B PIP4K2C MAPKAP1 VENTX MOV10 EZH2 PPARG PCNA SLC2A3 FKBP5 RICTOR MBD3 RFC5 MSX2 RFC3 SUZ12 OPRM1 GATAD2B MAF RFC4 GATAD2A DLX5 DLX6 RFC2 TWIST2 HIVEP3 RPA2 PPARGC1B ESRRA SMAD1 RPA3 SMAD6 BMP2 FOXO6 ITGBL1 FOXO4 SP7 AGO3 UCMA FOXO1 ZNF521 AGO4 NKX3-2 AGO1 RBM14 CBX6 AGO2 HAND2 NR4A1 PPM1D BGLAP PRR5 PTEN CHD4 CHD3 NR2E1 EED BRIP1 HDAC5 KAT5 EXO1 RBBP8 MTA2 NBN BARD1 RMI2 TNRC6C RMI1 TRPC3 STUB1 TOP3A TNRC6A RAD51D RAD50 TNRC6B RAD51 PRDX2 PRDX1 STAT1 SMARCD1 SMARCD2 SMARCB1 ARID2 YAF2 SMARCE1 CCNK SMARCC1 SMAD4 PBRM1 ZFHX3 TP53RK MT-CO1 SMARCC2 EHMT1 ACTL6B NOC2L AUTS2 GLS PCGF5 TP53AIP1 ARID1A SMARCA2 HUS1 COX7A2L ARID1B SCO1 RYBP SCO2 DDIT4 MT-CO2 MT-CO3 RHNO1 L3MBTL1 MEAF6 NUAK1 TP53BP2 ATRIP GTF2H1 PRELID3A GTF2H2 BANP PRELID1 GTF2H3 SURF1 GTF2H4 GTF2H5 TPX2 DDB2 SOD2 RAD17 CDK12 ATR COX7B ERCC3 ELL IFNG SETD9 ERCC2 CHM COX7C BBC3 TAF7L ING5 ING2 PIP4P1 EHMT2 AIFM2 ELOA COX8A CBX3 BRD1 SGK1 MEF2C COX5B LMO1 COX5A LMO2 PMS2 TAF9B BRD7 TIGAR MLH1 HIPK1 COX6C POU4F2 LRPPRC HIPK2 PRKAA1 TTC5 PRKAA2 CCNG1 TCEA1 MAP2K6 RAD1 CCNT2 YWHAB PRKAG1 CCNT1 PRKAG2 TACO1 PRKAG3 PRDM1 COX6A1 RPTOR STK11 SESN3 SESN2 AKT2 KMT5A BNIP3L MLST8 SUPT16H AKT1 IGFBP3 SLC38A9 COX6B1 MSH2 FANCD2 PRKAB2 KAT6A MAPKAPK5 COX19 COX16 COX18 TSC2 NDRG1 TSC1 PRKAB1 SMYD2 MTOR PMAIP1 COX11 PPM1A COX14 BCL2L14 RRAGA ZNF420 PTPN4 RRAGC FANCI BRPF1 RHEB BRPF3 RRAGB TNFRSF10C ELOA2 RRAGD SPI1 LAMTOR2 FANCC LAMTOR1 CDK9 LAMTOR4 TP53I3 LAMTOR3 RUNX1 JMY CYCS TAL1 LAMTOR5 TAF4B RARA RAD9B TGFB1 RAD9A CEBPB KMT2A COX20 DYRK2 CBFB PPP1R13B COX4I1 RXRA TRIAP1 DEK PPP1R13L TOPBP1 GPX2 RABGGTB RABGGTA RRM2B TMEM219 GLS2 TAF9 TAF1L TP53INP1 RFFL TAF15 TAF12 TAF13 NDUFA4 TAF10 TXNRD1 TAF11 SSRP1 TAF7 TAF6 LBR TAF5 PPARGC1A TAF4 TAF3 TAF2 TAF1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 MED23 MED25 MED24 MED20 PPARA RSPO3 JAG1 CAV1 YY1 KMT2D KMT2C MED30 MED31 USP7 USP9X HDAC6 ITGA5 PGR PPP2R1B CLDN5 SERPINB13 SP1 SOCS4 AXIN1 CCNC GP1BA PF4 PCK1 WWTR1 SMARCA4 HNF4G NR5A1 YAP1 PERP GCK SMAD7 TCF3 LDB1 MYBL2 H3-3B CCNA2 CCNA1 NOTCH2 NOTCH3 NOTCH4 KMT2E DNA2 KMT2B POLR2A DPY30 POLR2B MED1 POLR2C POLR2D MED8 POLR2E POLR2F MED4 POLR2G POLR2H POLR2I MED6 POLR2J SETD1B POLR2K MED7 POLR2L SETD1A RARG PPP2R5C ASH2L ELOB ELOC TEAD1 TCF12 RARB MAPK14 IRAK1 DLL1 PLXNA4 CDK8 SMAD2 SMAD3 MYB WDR5 ZFPM1 GATA4 GATA3 GATA2 GATA1 SMARCD3 ABL1 NFE2 RBBP5 CBX5 CDK5 KLF4 SOX2 SOX9 H3C8 HEY1 HEY2 RXRB HDAC2 H3C15 TCF7L2 TCF7L1 MYC TCF7 LEF1 CTNNB1 RUNX3 PHF20 CHEK2 ZNF385A PCBP4 MDM2 MDM4 ATM KIT CDK5R1 NR1H2 THBS1 OPRK1 IL6 DGCR8 GAMT PLK2 RBFOX1 GPRIN1 PVALB HTT MOBP GAD1 GAD2 OCLN TJP1 NOP2 CGA HSPD1 NFYA NFYB DDIT3 NFYC CRH POMC INS RNF111 NEDD4L CAMK2B GRIA2 CAMK2D SRC CAMK2A GRIN2B GRIN2A CALM1 CAMK2G BAX BID WWP1 CSNK2A1 CSNK2A2 CSNK2B KCTD6 SOCS3 G6PC1 SMURF2 SMURF1 FBXO32 TRIM63 RNF34 AKT3 GPAM JUN FOS YWHAE PPP2R1A PRKACA YWHAG BLK SKP1 ELF1 ELF2 PAX5 PIDD1 APAF1 CRADD SERPINE1 CASP6 RORA CASP1 NR3C1 CASP2 NLRC4 TP63 TP73 SREBF1 UBA52 NR1D1 CUL1 AURKA AR CCNB1 UBB MYL9 UBC RPS27A USP2 BCL2L11 SFN CENPJ BDNF TNFRSF10B TNFRSF10A CDK1 TNFRSF10D ZNF17 FASLG ZNF287 ZNF18 PTPN11 ZNF19 ZNF285 ZNF282 RBX1 ZNF10 ZNF12 ZNF14 ZNF705EP ZNF28 PSMD8 ZNF274 PSMD9 ZNF273 FAS PSMD6 ZNF20 PSMD7 ZNF23 PSMD4 ZNF25 PSMD5 ZNF26 PSMD2 ZNF268 PSMD3 ZNF267 PSMD1 ZNF266 ZNF264 ZNF263 NR2F1 TXNIP ZNF34 PRKCB NR0B2 PSMA5 NR2F6 PSMA6 ZNF30 PSMA3 ZNF257 PSMA4 ZNF256 PSMA1 ZNF254 PSMA2 PSME3 ZNF496 PSME4 ZNF253 PSME1 ZNF493 PSME2 ZNF250 ZNF492 ZNF490 PSMD10 ZNF43 PSMB11 ZNF45 PSMD12 ZNF41 PSMD11 ZNF248 PSMD14 ZNF486 PSMD13 ZNF485 ZNF484 PSMA7 ZNF483 RELA ZNF480 ZNF479 PSMB10 ZNF235 PSMA8 ZNF234 PSMB6 ZNF233 PSMB7 PPARD PSMB4 FOXP3 ZNF230 PSMB5 ZNF471 PSMB2 ZNF470 PSMB3 PSMB1 ZNF227 MEN1 PSMF1 ZNF468 ZNF226 NFKB1 ZNF225 PSMB8 ZNF224 PSMB9 ZNF223 CDC25C ZNF222 SEM1 ZNF221 PSMC5 ZNF461 PSMC6 ZNF460 PSMC3 ZNF77 PSMC4 ZNF79 PSMC1 SKI PSMC2 ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 ZNF213 NCOR2 ZNF697 HDAC3 ZNF454 NCOR1 ZNF696 TBL1XR1 ZNF212 HDAC1 ZNF211 SIN3A ZNF692 CAMK4 ZNF691 GPS2 RORB TBL1X ZNF208 ZNF205 ZNF689 ZNF688 ZNF446 ZNF445 PITX2 EGFR ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 ZNF682 ZNF440 ZNF681 ZNF680 ITGAL ZFP69B ZNF439 ZNF679 ZNF678 ZNF436 ZNF677 ZNF676 ZNF433 ZNF675 ZNF432 ZNF431 ZNF430 ITGA4 ZNF671 BIRC5 ZNF670 TNFRSF18 ZNF840P ZKSCAN7 ZNF429 ZKSCAN8 ZNF669 ZKSCAN3 ZNF668 ZNF426 ZNF667 ZNF425 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 ZKSCAN1 ZNF662 ZNF660 ZNF419 IL2RA ZNF418 ZNF417 ZNF658 ZNF416 ZNF415 ZNF655 NPPA ZNF649 TBX5 ZNF641 NKX2-5 ZNF875 ZNF627 ZNF626 ZNF625 SST ZNF624 ZNF621 ZNF620 ZNF860 LGALS3 MGA ZNF619 CTSV ZNF616 ZNF615 ZNF614 ZNF613 ZNF611 ZNF610 TRIM33 CTSL IHH UXT ZNF729 TRIM28 CTSK ZNF727 PRMT6 ZNF726 NR4A3 ZNF724 EPC1 ZNF721 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 ZNF324B HDAC4 L3MBTL2 ZNF709 ZNF708 SATB2 ZNF707 ZNF706 ZNF704 MMP13 ZNF703 ZNF701 ZNF700 SPP1 HNF4A ZFP14 ZNF585B RXRG ZNF585A ZFP28 PRDM7 IGFBP1 ZNF99 ZNF92 H2AX VDR H2AB1 H2AC19 TGIF1 ZNF75CP H2AC14 H2BC12L TGIF2 ZNF804B H2BC21 ZNF175 ZSCAN32 ZNF169 H2BU1 ZNF705G H2AC8 ZNF705D H2AC6 ZNF160 H2AC7 ZNF705A H2BC17 ZSCAN25 H2BC12 ZNF157 H2BC13 ZNF398 STEAP3 H2BC14 ZNF155 ZNF154 H2AJ H2BC15 ZNF394 H2BC11 NR2C2AP ZNF141 ZNF383 ZNF140 ZNF382 RBBP4 NR1D2 RBBP7 H2AZ1 H2BC9 ZNF37A H2AZ2 ZNF702P ZNF138 NPM1 ZNF136 ZNF135 H4C9 H2BC8 ZNF133 ZNF124 ZIK1 H2BC5 ZNF599 H2BC3 ZNF114 ZNF597 H2BC1 CAT ZNF596 ZNF112 ZNF595 ZNF350 RETN H2AC20 ZNF589 ZNF347 ZNF473 ZNF587 ZNF586 ZIM2 BTG1 ZNF343 MSTN ZNF101 SIRT3 ZIM3 FOXG1 ZNF584 ZNF100 NPY ABCA6 ZNF583 UBE2D1 PINK1 ZNF582 CCNG2 PCGF6 AGRP ZNF33B ZNF33A ZNF337 ZNF577 ZNF334 ZNF333 ZNF573 ZNF331 ZNF571 ZNF570 ZFP30 ZNF569 ZNF568 NFATC2 ZNF567 ZNF324 ZNF566 HDAC10 GPI ZNF565 ZFP37 YWHAQ ZNF564 ZNF563 ZNF320 HDAC8 PRKCQ ZNF562 YWHAH ZNF561 ZNF560 NRBP1 ZNF317 ZNF559 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 YWHAZ ZNF554 MRE11 ZNF311 ZNF552 CSF2 ZNF793 ZNF551 ZNF792 ZNF550 ZNF791 ZNF790 KRBA1 KRBOX4 KRBOX5 ZNF767P ZNF549 AURKB ZNF548 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 ZNF782 ZNF540 ZNF658B ESRRB MAPK11 ESRRG ZFP69 ZNF778 ZNF777 ZNF776 ZNF775 ZNF774 ZNF773 MAX ZNF772 E2F5 ZNF530 PDPK1 ZNF771 BCL6 ZNF770 COL1A1 CDC7 ZNF529 ZNF528 ZNF764 ZNF761 ZNF75D ZFP90 E2F6 ZNF75A CR1 ZNF519 CDKN2B ZNF517 RRM2 ZNF514 ZNF510 ZNF750 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 ZNF740 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 ZNF607 ZNF606 YES1 ZNF605 ZNF600 ZNF839 ZNF726P1 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B ATP1B4 NR4A2 THRB THRA GSK3B ZNF197 ZNF195 GLI3 NR2C2 GLI2 NR2C1 ZNF189 ZNF286A ZNF184 ZNF180 TWIST1 ITCH CREBBP NOTCH1 MAML2 MAML1 RBPJ KAT2B KAT2A SNW1 EP300 GTF2F1 HES1 MAML3 GTF2F2 MAMLD1 TP53 LIFR TFAP2A TFAP2B PRMT5 WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 ACTL6A UBE2D3 CCNH SIN3B CASP10 TBP SIRT1 CDK7 MNAT1 TEAD4 CCN2 TEAD2 CTLA4 TEAD3 PIN1 RB1 CDKN1A ANAPC15 CDKN1B ANAPC16 ANAPC10 ANAPC11 RORC FZR1 CCND3 CDC23 CCND2 CCND1 CDC26 CDC27 E2F1 SKP2 DAXX ANAPC7 UBE2C UBE2E1 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2CA PPP2CB MAPK1 MAPK3 PTPN1 G6PD ATXN3 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CHEK1 APOE CITED1 CITED2 CITED4 YEATS4 MET TGFA ESR1 ESR2 IL2 IL3 CGB8 ATAD2 BTG2 TNKS1BP1 CNOT6L PRMT1 RBL2 RBL1 PLAGL1 E2F4 E2F7 E2F8 PLK3 GADD45A ARID3A CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT1 CNOT11 CARM1 CNOT2 CNOT3 CNOT8 CNOT9 FOXO3 JUNB CREB1 ERBB2 CDK13 ITGA2B VEGFA MDC1 BRCA1 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.2 Defective ALG1 causes CDG-1k ALG1 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 80%159424 Conjugation of carboxylic acids ACSM5 ACSM4 GLYATL3 GLYATL2 GLYATL1 ACSM1 ACSM2A GLYAT ACSM2B DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.2 Defective DPM3 causes CDG-1o DPM2 DPM3 DPM1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190372.3 FGFR3c ligand binding and activation GALNT3 FGF1 FGF16 FGF2 FGF18 FGF4 FGF9 FGF20 FGF23 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 80%73772 RNA Polymerase I Promoter Escape H3C15 CCNH H2AX H3-3B H2AB1 H2AC19 H2AC14 UBTF H2BC12L H2BC21 TBP H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H H2BC14 H2AJ H2BC15 TAF1D H2BC11 TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H H2AZ1 POLR2K H2BC9 CDK7 POLR2L MNAT1 H2AZ2 GTF2H1 H4C9 H2BC8 GTF2H2 GTF2H3 GTF2H4 H2BC5 GTF2H5 H2BC3 H2BC1 ERCC3 H2AC20 ERCC2 RRN3 CBX3 H3C8 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%9033807 ABO blood group biosynthesis FUT2 FUT1 ABO SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 80%8851708 Signaling by FGFR2 IIIa TM POLR2J POLR2K POLR2L NCBP1 NCBP2 POLR2A GTF2F1 POLR2B FGF1 GTF2F2 POLR2C FGF2 POLR2D POLR2E FGFR2 POLR2F POLR2G POLR2H POLR2I SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 80%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMD8 FZR1 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 FBXO5 UBA52 CUL1 UBB UBC RPS27A CDC20 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 80%110320 Translesion Synthesis by POLH RPA3 RPS27A RCHY1 POLH SPRTN NPLOC4 UBA52 VCP PCNA UFD1 RPA1 RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.2 Degradation of beta-catenin by the destruction complex PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 CSNK1A1 PSMD1 PSMA5 PSMA6 PSMA3 TLE4 PSMA4 TLE2 PSMA1 TLE1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA TCF7L2 PPP2CB TCF7L1 AMER1 TCF7 PSMB10 LEF1 PSMA8 PSMB6 CTNNB1 PSMB7 PSMB4 PSMB5 PPP2R1A PSMB2 PSMB3 PSMB1 PSMF1 BTRC PPP2R5D PSMB8 PSMB9 TLE3 SEM1 PSMC5 PPP2R1B PSMC6 SKP1 PSMC3 APC PSMC4 PSMC1 PSMC2 AXIN1 HDAC1 UBA52 TLE5 CUL1 UBB CTBP2 CTBP1 ZRANB1 UBC FRAT1 FRAT2 RPS27A PPP2R5E GSK3B PPP2R5B PPP2R5A RBX1 PPP2R5C TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 80%5656169 Termination of translesion DNA synthesis UBE2L6 REV1 POLI UBA52 TRIM25 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC POLE4 UBA7 RPS27A RPA3 POLE2 POLE3 USP10 POLH PCLAF USP43 ISG15 RPA1 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013420 RHOU GTPase cycle VANGL1 ITSN2 CDC42 DST CLTC PAK1 TXNL1 ARHGAP31 PAK3 ARHGAP30 PAK2 PIK3R1 SRC GIT1 DLG5 SPTBN1 WWP2 STAM NCK2 NCK1 DEPDC1B USP9X EPHA2 IQGAP1 PEAK1 SPTAN1 PIK3R2 STAM2 MYO6 PARD6A HGS PTK2B RHOU SRGAP2 PAK4 ARHGEF7 GIT2 ARHGEF6 WDR6 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.2 Citric acid cycle (TCA cycle) CS ME3 ME2 IDH3A SDHC SDHD SDHA ACO2 SDHB SUCLG2 SUCLG1 FH FAHD1 IDH2 MDH2 IDH3G SUCLA2 OGDH DLST DLD NNT IDH3B EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 80%114508 Effects of PIP2 hydrolysis PRKCE ITPR1 ITPR2 ITPR3 PRKCQ PRKCD PRKCH RASGRP2 RASGRP1 DGKG DGKE DGKD DGKB DGKA DGKZ DGKQ DGKK ABHD12 TRPC7 DGKI DAGLA MGLL DGKH ABHD6 TRPC6 DAGLB TRPC3 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.3 Dissolution of Fibrin Clot SERPINB2 S100A10 ANXA2 HRG SERPINB8 PLAU PLG SERPINE2 PLAT SERPINE1 PLAUR SERPINB6 SERPINF2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 80%69278 Cell Cycle, Mitotic NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 SMC1A NUP93 FBXL7 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 RAD21 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 CSNK2A1 CDKN2A CSNK2A2 RPA1 NUP153 STAG1 CSNK2B STAG2 NUP35 NUP37 TUBB8 TUBB8B TNPO1 AKT3 PCNA POLD3 POLD4 POLD1 FBXL18 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 LPIN1 RFC2 LPIN2 RPA2 LPIN3 CEP57 YWHAE POLE4 CETN2 RPA3 CEP164 POLE2 CCP110 POLE3 PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 OFD1 HSP90AA1 CEP135 PPP1R12A BORA FBXW11 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 GOLGA2 CSNK1E TUBG1 ANKLE2 DYNLL1 CDC25B CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 UBA52 SFI1 AJUBA OPTN SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 DYNC1LI1 CCNB1 DYNC1LI2 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 CDCA8 RPS27A PCNT CEP76 CLASP1 CEP78 SKA1 PLK4 SKA2 DYNC1H1 ODF2 NDE1 TPX2 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 NUF2 GINS4 NUDC RBX1 MCM3 MCM4 MCM5 DYNLL2 MCM6 JAK2 MCM2 PSMD8 INCENP PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 AKT2 PSME3 KMT5A PSME4 PSME1 AKT1 PSME2 PSMD10 CENPF PSMB11 TAOK1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 CDC25C SEM1 PSMC5 PSMC6 PSMC3 CLIP1 PSMC4 PSMC1 PSMC2 MAD1L1 IST1 HDAC1 NDC80 EMD LBR GMNN ORC5 SPDL1 SET LEMD3 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 RANGAP1 BIRC5 NSL1 ZW10 DSN1 RCC2 ZWINT AHCTF1 VRK1 LEMD2 SIRT2 XPO1 NDEL1 PPP2R5D PPP2R1B MIS12 H2AX H2AB1 H2AC19 DYNC1I1 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 B9D2 H2AC6 GORASP2 BLZF1 H2AC7 KNL1 SPC24 SPC25 H2BC17 ERCC6L H2BC12 H2BC13 H2BC14 H2AJ ZWILCH H2BC15 H2BC11 ITGB3BP CENPA CENPC RBBP4 H2AZ1 KNTC1 H2BC9 CENPT H2AZ2 CENPU SGO1 H4C9 H2BC8 SGO2 H2BC5 H2BC3 H2BC1 CENPH PMF1 CENPI H2AC20 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS UBE2D1 CTDNEP1 CNEP1R1 USO1 LMNB1 PPP2R2A PPME1 PHLDA1 GTSE1 LYN FKBPL TUBGCP2 HMMR PKMYT1 TUBGCP5 TUBGCP6 AURKB TUBGCP3 TUBGCP4 LIN54 FOXM1 MYBL2 LIN52 BUB1 TUBG2 CLASP2 MZT2B RPS27 MZT2A NME7 LIN37 LIN9 LCMT1 CDK11A PPP2R3B CDK11B MZT1 RAB1A FEN1 RAB1B CKS1B MAX E2F5 H3-3B FBXO5 DYRK1A PTTG1 CDC7 DHFR CCNA2 TOP2A CCNA1 MCM10 TK1 DBF4 NCAPH2 TYMS NCAPG2 E2F6 CDKN2D DNA2 MCPH1 CDKN2B NCAPD3 PRIM2 RRM2 CDKN2C PRIM1 RPA4 ESCO1 CDCA5 PDS5B ESCO2 PDS5A WAPL POLA1 POLA2 H3-4 PPP2R5E GSK3B PPP2R5B PPP2R5A PPP2R5C CDC14A BANF1 RAB2A NUMA1 EP300 TP53 EML4 NEK9 NEK6 NEK7 PPP2R2D ENSA RCC1 MASTL ARPP19 RAN KPNB1 UBE2I SUMO1 HSP90AB1 KIF20A CCNH GORASP1 ABL1 SPAST CC2D1B ESPL1 KIF18A NCAPG NCAPD2 CDK7 SMC4 MNAT1 NCAPH SMC2 VPS4A RB1 CDKN1C CDKN1A H3C8 CHMP2B ANAPC15 CHMP4C CDKN1B CHMP2A ANAPC16 KIF23 CHMP4B ANAPC10 CHMP3 ANAPC11 FZR1 CHMP4A CCND3 CHMP6 CDC23 CHMP7 CCND2 CCND1 CDC26 CDC27 KIF2A E2F1 E2F2 E2F3 SKP2 KIF2C KIF2B ANAPC7 UBE2C UBE2E1 H3C15 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CABLES1 CCNE1 CDC16 CENPE CDK2 ANAPC4 WEE1 ANAPC5 ANAPC1 ANAPC2 PPP2CA PPP2CB MYC MAPK1 PTK6 BUB1B CDC20 BUB3 MAD2L1 CDC25A TUBB6 TUBB3 TUBB1 TUBA4B TUBA8 TUBA1C TUBA1B RBL2 RBL1 E2F4 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C NIPBL MAU2 NUP107 NUP188 SMC3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 80%500792 GPCR ligand binding CCL19 CCL22 CCL20 AVP TBXA2R FFAR3 GPR31 FFAR2 UCN OPRD1 CXCR1 CXCR2 C5AR2 C5AR1 CXCL8 CXCL1 CXCL2 OPRM1 S1PR1 HEBP1 ANXA1 MT-RNR2 FPR1 FPR3 FPR2 WNT5A WNT11 FZD3 FZD2 FZD5 FZD4 FZD6 TAS2R7 TAS2R60 TAS2R40 TAS2R9 TAS2R41 TAS2R8 TAS2R20 TAS2R42 TAS2R43 TAS2R45 C3AR1 TAS2R46 GRM3 GPRC6A GRM2 GRM5 GRM4 GRM7 GRM6 GRM8 TAS2R1 TAS1R2 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 CASR TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 TAS2R16 TAS2R39 TAS2R19 PTAFR WNT2B WNT8A WNT8B WNT6 WNT2 DHH WNT3 WNT4 WNT10A WNT3A WNT7B WNT9B WNT7A WNT9A WNT16 GABBR2 GABBR1 FZD1 FZD8 SST SHH IHH GRP FFAR4 FFAR1 CXCL12 PPBP KNG1 F2R F2 PENK SSTR3 PF4 AGTR1 MCHR1 RHO ADGRE5 ADGRE3 NPY TACR1 WNT1 FZD10 CRHBP FZD9 UCN3 UCN2 PTCH2 ADGRE1 ADGRE2 CHRM2 CHRM3 CHRM1 SMO CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRA1D ADRB2 HTR2A PTCH1 HTR4 ADRA1B ADRA1A WNT10B TAAR3P CXCL6 HTR6 GNAS CXCL9 CXCL13 HRH1 HTR7 CXCL3 HRH3 CXCL5 CX3CL1 HRH2 CXCL16 HRH4 PTGIR DRD1 CCRL2 DRD2 CCR9 DRD3 CCR8 DRD4 CCR7 DRD5 CCR4 TAAR8 CCR3 HTR1E XCL2 TAAR9 XCL1 HTR1F CX3CR1 TAAR6 CCL13 HTR1D CXCR5 HTR1A CXCR6 TAAR5 CCL7 HTR1B CXCR3 TAAR2 CCL1 CCL17 ADRA2C CCL16 HTR5A TAAR1 CCR10 CCL25 ADRA2B ADRA2A XCR1 CCL21 GPR143 CXCL11 ADRB3 ACKR4 ACKR3 ACKR2 CCL28 CCL27 IAPP C3 APP NPFFR2 NPFFR1 RXFP4 RRH GRPR RXFP3 EDNRA EDNRB OXER1 PROK2 PROK1 CMKLR1 OXTR UTS2R AVPR1B NPFF OXT C5 GPR37L1 AVPR1A PDYN TRHR UTS2B KEL AGTR2 PTGFR LPAR1 LPAR2 LPAR3 LPAR4 NLN GALR3 GALR2 GALR1 NPBWR1 NPBWR2 CYSLTR1 PPY HCRT NTSR1 NTSR2 GPR17 NMB NMBR SAA1 LPAR5 LPAR6 NMS GPR183 NMU PNOC GNRH2 GNRH1 GPR18 PTGDR2 QRFP MLN BRS3 GPR132 CCKAR OPN1LW GNRHR OXGR1 EDN1 GPR37 EDN2 EDN3 GPR35 TACR2 TACR3 GAL OPN1MW CCKBR RGR NPB PLPPR1 PLPPR2 PTGER1 PLPPR3 PLPPR4 PTGER3 PLPPR5 PROKR1 CXCL10 PROKR2 NPW KISS1R PRLH P2RY12 P2RY13 P2RY10 P2RY14 GPR55 GPR4 AGT CCL5 XK CCL4 F2RL1 CCL3 F2RL2 CCL2 F2RL3 GPR68 GPR65 PMCH NPY2R ADORA3 ADORA1 GHSR CXCR4 NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 NTS MCHR2 HCAR2 HCAR3 HCAR1 TAC3 TAC1 OPN4 OPN3 OPN5 PYY NMUR2 NMUR1 MLNR ECE1 ECE2 TRH LTB4R BDKRB2 BDKRB1 PRLHR CCR1 QRFPR INSL5 NPY5R GNRHR2 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 P2RY6 CNR2 P2RY4 CNR1 P2RY2 P2RY1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HCRTR2 HCRTR1 APLN KISS1 OPN1SW CCR6 ACKR1 CCR5 CCR2 VIPR1 VIPR2 SCT RXFP1 RXFP2 CYSLTR2 CD55 PTGDR LHCGR ADCYAP1 CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB CRHR1 GHRHR MC2R CALCR CGA PSAP GNG10 MC1R RLN2 RLN3 GNG12 GNG11 CCL3L3 GLP1R GNG13 ADM GNB2 PTH1R MC4R GNB1 GNB4 GPER1 FZD7 INSL3 GNB3 TSHB GPR39 GNB5 FSHB GLP2R AVPR2 GNGT1 GPBAR1 PTH2R GNGT2 GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 PTH PTGER2 PTH2 PTHLH NPS GPHA2 P2RY11 GNG3 SCTR GCG GNG2 GNG5 TSHR GNG4 POMC GHRH ADM2 GNG7 MC5R GNG8 VIP RAMP1 GPHB5 CCL11 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9696270 RND2 GTPase cycle FAM83B ARHGAP5 ANKRD26 VANGL1 ARHGAP35 DST TXNL1 SCRIB PTPN13 CKAP4 KTN1 PIK3R1 NISCH RND2 VANGL2 UBXN11 DLG5 FNBP1 KCTD13 DSG1 KIDINS220 PKP4 RBMX FRS2 FRS3 PRAG1 LEMD3 KIF14 DEPDC1B UHRF1BP1L EPHA2 PLXND1 PIK3R2 ALDH3A2 LRRC1 TFRC TNFAIP1 NUDC MUC13 CAV1 GOLGA3 ARHGAP1 WDR6 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.2 Vasopressin regulates renal water homeostasis via Aquaporins ADCY3 GNGT2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 RAB11FIP2 AQP1 MYO5B GNG3 GNG2 GNG5 GNG4 PRKAR2B GNG7 GNG8 PRKACG PRKACB AVP ADCY9 AQP4 PRKAR1B AQP2 GNG10 PRKAR1A AQP3 RAB11A PRKAR2A GNG12 PRKACA GNG11 GNG13 GNB2 GNAS GNB1 GNB4 GNB3 GNB5 GNGT1 AVPR2 ADCY4 PKB-MEDIATED EVENTS%REACTOME%R-HSA-109703.4 PKB-mediated events PDE3B AKT2 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 80%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME DATABASE ID RELEASE 80%5683177 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 80%111957 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 80%139853 Elevation of cytosolic Ca2+ levels P2RX3 P2RX2 ORAI2 P2RX1 ORAI1 ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 STIM1 P2RX4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.2 Ionotropic activity of kainate receptors NCALD DLG1 DLG3 GRIK5 GRIK3 DLG4 GRIK4 GRIK1 GRIK2 CALM1 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 80%450604 KSRP (KHSRP) binds and destabilizes mRNA EXOSC2 EXOSC1 KHSRP DIS3 DCP2 PARN AKT1 MAPK14 EXOSC7 EXOSC6 MAPK11 EXOSC5 EXOSC4 EXOSC9 YWHAZ EXOSC8 EXOSC3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.2 Metalloprotease DUBs BRCC3 H2AC19 H2AC14 H2AW UBA52 H2AC17 H2AC12 H2AC8 H2AC1 H2AC6 H2AC7 KAT2B H2AC21 STAM EP300 STAMBPL1 MYSM1 UBB PSMD14 UBC RPS27A NLRP3 ABRAXAS2 H2AC20 STAMBP BARD1 BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCA1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 80%2029485 Role of phospholipids in phagocytosis IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 FCGR1A IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 FCGR2A IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 PLPP5 V5-4 PLPP4 V1-7 V5-1 PLD4 V1-5 V1-3 PLA2G6 IGKV3D-20 PLD1 V5-6 PLD3 PLD2 IGLV3-19 PIK3R1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 PIK3CA IGHV3-48 IGLV3-25 PLCG1 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G PIK3R2 AHCYL1 PRKCE PIK3CB ITPR1 ITPR2 ITPR3 PLCG2 SYK PRKCD IGHV3-23 IGLV IGLV2-8 IGKV1-16 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.1 HSF1-dependent transactivation DNAJB1 HSP90AB1 MTOR HSF1 HSPA1L CAMK2B HSPA1B AKT1S1 HSPA1A CREBBP CAMK2D PTGES3 HSPA2 HSPA8 CAMK2A RPTOR HSPB8 MLST8 HSP90AA1 HSBP1 EP300 FKBP4 CRYAB CAMK2G GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 80%163841 Gamma carboxylation, hypusine formation and arylsulfatase activation ICMT GGCX ARSA DPH1 F10 DPH2 DPH3 DPH5 DPH6 SUMF2 DPH7 SUMF1 F2 F7 F8 PROC F9 PROZ DNAJC24 ARSL ARSJ ARSK GAS6 ARSH ARSI ARSF FN3KRP BGLAP ARSG EEF2 ARSD TPST2 ARSB TPST1 FURIN EIF5A FN3K DHPS EIF5A2 PROS1 DOHH STS ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 80%68949 Orc1 removal from chromatin PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 CDK2 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 UBA52 CUL1 ORC5 ORC4 ORC6 ORC1 UBB ORC3 ORC2 CDT1 CDC6 UBC RPS27A MCM7 MCM8 RBX1 MCM3 MCM4 MCM5 MCM6 MCM2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.3 RNA Polymerase II Promoter Escape TAF9B TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2B GTF2E1 GTF2E2 ERCC3 ERCC2 TAF4B TAF7L GTF2A1 GTF2A2 NEGATIVE REGULATION OF FLT3%REACTOME%R-HSA-9706369.1 Negative regulation of FLT3 PTPRJ RPS27A FLT3 SLA2 FLT3LG UBA52 CBL CSK ABL2 SLA SH2B3 SOCS2 SOCS6 UBB UBC G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 80%202040 G-protein activation PDYN GNGT2 GNG10 GNG12 GNG11 GNG13 GNAQ GNB2 GNA14 GNB1 GNB4 GNA15 GNG3 GNB3 OPRM1 GNG2 GNG5 GNB5 POMC GNG4 GNA11 GNG7 GNGT1 GNG8 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 80%210745 Regulation of gene expression in beta cells FOXA2 PDX1 FOXO1 HNF4G HNF1A IAPP RFX6 SLC2A2 AKT3 PAX6 NEUROD1 NKX6-1 INS MAFA NKX2-2 AKT2 AKT1 GCK FOXA3 SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.1 Sensory perception of sour taste OTOP1 KCNJ2 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 80%8985947 Interleukin-9 signaling IL2RG IL9R JAK1 STAT5A STAT3 STAT5B STAT1 IL9 JAK3 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.1 Mitochondrial translation MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPS21 MRPL47 MRPL48 MRPS7 MRPL45 GFM2 MRPS6 MRPL46 MRPL43 MRPS5 MRPS18C TUFM MRPL44 MRPL52 MRRF OXA1L MRPL53 MRPS9 MTFMT MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPS33 MRPL18 MRPL19 MRPS34 MRPS31 MTRF1L MRPL16 MRPL17 MTIF2 MRPL58 MTIF3 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.1 Biosynthesis of EPA-derived SPMs ALOX15 PTGS2 HPGD ALOX5 LTA4H TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.2 Transcriptional activation of mitochondrial biogenesis MTERF1 GABPA HELZ2 TWNK SIRT4 SIRT5 PPRC1 POLG2 PERM1 NRF1 CREBBP IDH2 GLUD1 GLUD2 SSBP1 CALM1 TFB1M PPARGC1B ESRRA ACSS2 NCOA2 ATP5F1B CHD9 CYCS RXRA CRTC2 CRTC3 CRTC1 HCFC1 HDAC3 TGS1 NCOR1 TBL1XR1 CAMK4 TBL1X SMARCD3 PPARGC1A CARM1 NR1D1 MED1 CREB1 TFAM TFB2M POLRMT NCOA1 SOD2 NCOA6 PPARA SIRT3 ATF2 ALAS1 MEF2C MEF2D DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME DATABASE ID RELEASE 80%5619077 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 80%199920 CREB phosphorylation RPS6KA2 MAPKAPK2 RPS6KA1 ATF1 CREB1 RPS6KA3 RPS6KA5 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 80%5576892 Phase 0 - rapid depolarisation SCN9A CAMK2B CAMK2D CAMK2A SCN8A SCN11A CACNG8 CACNA1C CACNA2D2 CACNG4 SCN3B SCN3A CALM1 CAMK2G CACNB1 CACNB2 FGF14 SCN2A SCN10A FGF13 SCN2B FGF12 FGF11 SCN5A SCN4A SCN4B CACNG6 CACNG7 RANGRF SCN7A SCN1B SCN1A PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 80%73614 Pyrimidine salvage UPP2 UPP1 TYMP UCKL1 CDA UCK2 DCK UCK1 PUDP TK2 TK1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 80%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) HEPH SLC40A1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.2 RPIA deficiency: failed conversion of RU5P to R5P RPIA ARMS-MEDIATED ACTIVATION%REACTOME%R-HSA-170984.5 ARMS-mediated activation NTRK1 CRK KIDINS220 NGF RAP1A YWHAB BRAF DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.1 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.3 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 GCKR NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP107 NUP188 NUP35 GCK NUP37 DNA METHYLATION%REACTOME DATABASE ID RELEASE 80%5334118 DNA methylation DNMT3A H2AX H3-3B H2AB1 H2AC19 UHRF1 H2AC14 H2BC12L DNMT3B H2BC21 H2BU1 H2AC8 H3C15 DNMT3L H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 DNMT1 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H3C8 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 80%209776 Metabolism of amine-derived hormones DDC DIO3 TPH1 DUOX1 TPO AANAT ASMT IYD DUOX2 CGA PNMT TH DBH SLC5A5 TSHB DIO1 TPH2 DIO2 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.1 Diseases of nucleotide metabolism APRT PNP HPRT1 ADA SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.5 SUMOylation of transcription cofactors BMI1 SUMO3 SIN3A SUMO2 PIAS4 HIPK2 RING1 UHRF2 CREBBP DAXX NRIP1 PPARGC1A PIAS1 TRIM28 MRTFA EP300 CTBP1 RNF2 PARK7 DDX17 NPM1 SAFB NCOA2 PIAS3 ZNF131 TOPORS NCOA1 CBX8 PHC2 PHC1 ZNF350 CBX4 DDX5 CBX2 PCGF2 UBE2I ING2 SUMO1 PHC3 CASP8AP2 NCOR2 MBD1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 80%429947 Deadenylation of mRNA PAIP1 CNOT10 PAN2 CNOT4 CNOT6 PAN3 CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B EIF4A3 TUT7 TUT4 EIF4G1 PABPC1 PARN EIF4A2 EIF4A1 TNKS1BP1 CNOT6L MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.1 Modulation by Mtb of host immune system RPS27A TLR2 MRC1 UBB UBA52 B2M UBC NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 80%196807 Nicotinate metabolism NAMPT RNLS NMNAT3 NMNAT2 NMNAT1 NAXD PTGIS CYP8B1 NAPRT PARP10 PARP6 PARP4 NADSYN1 PARP16 PARP9 PARP14 NUDT12 PARP8 NADK BST1 SLC5A8 NNMT QPRT NADK2 SLC22A13 NMRK2 PTGS2 NMRK1 CD38 NAXE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 80%622327 Postsynaptic nicotinic acetylcholine receptors CHRNG CHRNA4 CHRNE CHRNA6 CHRNA9 CHRNA7 CHRNB2 CHRNA1 CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.2 G protein gated Potassium channels GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNG10 KCNJ4 GABBR2 KCNJ5 GABBR1 KCNJ10 KCNJ12 GNG12 KCNJ9 GNG11 GNG13 KCNJ15 GNB2 KCNJ16 GNB1 GNB4 GNB3 GNB5 GNGT1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME%R-HSA-187706.2 Signalling to p38 via RIT and RIN NTRK1 NGF RIT1 RIT2 BRAF DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 80%5619081 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 80%5602498 MyD88 deficiency (TLR2 4) FGB FGA BTK HMGB1 FGG LY96 CD36 CD14 S100A1 MYD88 TIRAP TLR1 S100A9 TLR6 S100A8 TLR4 TLR2 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 80%975574 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 80%9690406 Transcriptional regulation of testis differentiation AMH NR5A1 ZFPM2 SRY DMRT1 SOX9 GATA4 PTGDS DHH FGF9 WT1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 80%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids MECR HADHB HADHA ACADL ECHS1 ACADM ACSM3 HADH ACSM6 ACADS ACADVL DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 80%3359454 Defective TCN2 causes TCN2 deficiency TCN2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.3 Activation of kainate receptors upon glutamate binding GNGT2 PLCB3 PLCB1 PLCB2 GNG3 DLG1 GNG2 DLG3 GNG5 GNG4 DLG4 GNG7 CALM1 GNG8 NCALD GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GRIK5 GRIK3 GNB5 GRIK4 GRIK1 GRIK2 GNGT1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 80%879415 Advanced glycosylation endproduct receptor signaling MAPK1 AGER MAPK3 HMGB1 LGALS3 PRKCSH S100A12 S100B SAA1 CAPZA1 DDOST APP CAPZA2 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%1369007 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.2 Response to elevated platelet cytosolic Ca2+ ACTN4 PRKCG TAGLN2 PRKCA TLN1 TEX264 APOH VCL MANF MAGED2 ECM1 OLA1 CTSW TOR4A STXBP3 LY6G6F APOOL LHFPL2 POTEKP FAM3C PRKCB ACTN2 TMX3 SELENOP TGFB2 CD9 TGFB3 RARRES2 FLNA CYRIB LGALS3BP AHSG PLEK SRGN MMRN1 CALM1 CLU STX4 CFL1 BRPF3 LAMP2 TGFB1 CD109 EGF IGF1 ALDOA THBS1 QSOX1 RAB27B PCDH7 LEFTY2 STXBP2 ACTN1 A2M PECAM1 CD63 PFN1 APOA1 HSPA5 ORM1 HGF ALB ORM2 CYB5R1 PDGFB TIMP1 PPBP PSAP CFD PLG PROS1 IGF2 F13A1 SERPINE1 KNG1 APP FGB FGA VWF APLP2 TUBA4A SCG3 FGG SPARC F5 SELP F8 TF CALU SERPING1 PF4 A1BG ISLR CHID1 SERPINF2 GTPBP2 SYTL4 NHLRC2 ENDOD1 VTI1B HRG FERMT3 GAS6 SERPINA4 TMSB4X TIMP3 CD36 ANXA5 SERPINA3 CAP1 SOD1 SPP2 PCYOX1L SERPINA1 ITGB3 ITGA2B VEGFB PPIA TTN VEGFC VEGFD SCCPDH VEGFA WDR1 PHACTR2 ITIH4 FN1 ITIH3 CLEC3B CDC37L1 HABP4 ABCC4 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 80%112307 Transmission across Electrical Synapses GJD2 GJC1 GJA10 PANX1 PANX2 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.2 Cell junction organization CDH6 CDH5 CDH3 PARD3 CDH24 CADM3 CADM1 CADM2 LAMC2 CDH10 CDH11 VASP CDH12 CDH13 ANG NECTIN4 CDH17 FERMT2 NECTIN3 CDH18 NECTIN1 FLNA PXN CDH4 CDH2 PVR PLEC CTNNB1 FBLIM1 ITGB4 TESK1 ILK F11R PARVA ITGA6 PARVB LAMA3 FLNC RSU1 LIMS2 SDK1 LIMS1 ITGB1 CLDN5 SDK2 CTNND1 LAMB3 CLDN2 CLDN1 CLDN22 ARHGEF6 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 DST CLDN4 CLDN3 CLDN15 CTNNA1 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CD151 CLDN19 CLDN18 CLDN17 CLDN16 PARD6G CDH1 PRKCI NECTIN2 PATJ PARD6B PARD6A JUP COL17A1 CRB3 CDH15 PALS1 CDH9 CDH8 CDH7 ACTN1 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.2 Retinoid metabolism and transport GPIHBP1 RBP4 LRP2 CLPS APOA2 RBP2 PNLIP APOC3 APOA1 APOA4 RBP1 APOC2 RETSAT LRP8 RDH11 SDC4 TTR LDLR SDC2 SDC3 APOM GPC1 GPC3 AKR1C1 SDC1 GPC2 GPC5 AKR1C3 GPC4 BCO2 AKR1C4 AGRN BCO1 GPC6 PLB1 LRP10 AKR1B10 LRP12 HSPG2 LRAT LPL APOE LRP1 APOB DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 80%73928 Depyrimidination H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 NTHL1 H2AC7 H2BC17 H2BC12 H2BC13 MBD4 H2BC14 SMUG1 H2AJ H2BC15 NEIL2 H2BC11 NEIL1 OGG1 H2AZ1 H2BC9 H2AZ2 TDG ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 80%6806834 Signaling by MET CRKL SH3GL2 EPS15 LAMC2 ARF6 LAMC1 HGF SH3GL3 RAB4A MET SRC GGA3 SH3KBP1 STAM SH3GL1 PTK2 PTPN2 HGS RANBP10 LAMA5 PTPN1 LAMA3 ITGA2 ITGB1 LAMA2 LAMA1 LAMB3 RANBP9 LAMB1 RAB4B RAC1 GAB1 UBA52 PIK3R1 SPINT1 CBL HPN SPINT2 NRAS HGFAC PIK3CA CRK SOS1 LRIG1 HRAS UBB RAPGEF1 UBC PTPRJ RPS27A TNS4 TNS3 MUC20 STAT3 STAM2 DOCK7 LAMB2 LAMC3 LAMA4 ITGA3 RAP1B RAP1A PTPN11 USP8 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 80%5696394 DNA Damage Recognition in GG-NER ACTR5 ACTL6A YY1 ACTR8 INO80C INO80B INO80E INO80D GPS1 COPS7B COPS4 COPS7A TFPT MCRS1 PARP1 INO80 COPS2 UBA52 RUVBL1 COPS3 COPS6 COPS5 COPS8 ACTB RAD23A RAD23B UBB XPC UBC CETN2 RPS27A PARP2 DDB2 CUL4A DDB1 CUL4B RBX1 NFRKB DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.1 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT2 POMT1 DAG1 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.1 Signaling by MAPK mutants DUSP9 DUSP6 DUSP7 MAPK1 DUSP16 DUSP10 DUSP8 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.1 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 80%5654695 PI-3K cascade:FGFR2 FGF22 FGF10 FGF16 FGF7 GAB1 FGF18 PIK3R1 PIK3CA FRS2 PTPN11 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 80%8941237 Invadopodia formation SH3PXD2A ADAM19 ADAM12 ADAM15 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME DATABASE ID RELEASE 80%5619095 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.2 Nucleotide catabolism ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 SAMHD1 ENTPD7 ENTPD8 NUDT16 NUDT5 NUDT15 ADPRM NT5C NT5C2 AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP PNP XDH GDA DNPH1 NT5C1B ITPA TIGHT JUNCTION INTERACTIONS%REACTOME%R-HSA-420029.1 Tight junction interactions CLDN11 CLDN6 CLDN10 PARD3 CLDN4 CLDN3 CLDN15 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 PARD6G PRKCI PATJ PARD6B PARD6A F11R CLDN5 CRB3 PALS1 CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 FORMATION OF APOPTOSOME%REACTOME%R-HSA-111458.3 Formation of apoptosome APIP CYCS MAPK1 XIAP DIABLO MAPK3 CARD8 CASP9 APAF1 UACA AVEN TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) GPS1 TCEA1 ZNF830 PCNA POLD3 POLD4 POLD1 POLD2 EP300 POLK POLE RFC5 ISY1 RFC3 USP7 RFC4 HMGN1 LIG1 RFC1 RFC2 RPA2 XRCC1 LIG3 POLE4 RPA3 POLE2 UVSSA POLE3 RPA1 CCNH COPS7B COPS4 COPS7A UBA52 COPS2 COPS3 AQR COPS6 COPS5 COPS8 PPIE POLR2A POLR2B POLR2C POLR2D UBB POLR2E POLR2F ERCC8 POLR2G POLR2H UBC POLR2I POLR2J PRPF19 POLR2K CDK7 RPS27A POLR2L MNAT1 XPA GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CUL4A DDB1 ERCC3 ELL ERCC4 ERCC1 ERCC2 ERCC5 CUL4B XAB2 RBX1 ERCC6 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 80%4720475 Defective ALG3 causes CDG-1d ALG3 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 80%2206281 Mucopolysaccharidoses ARSB IDS GNS HGSNAT GUSB GALNS IDUA SGSH GLB1 HYAL1 NAGLU KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 80%9664420 Killing mechanisms DVL2 MAPK8 DVL3 WNT5A NOXO1 CYBA FZD7 NOXA1 RAC1 JUN NOX1 DVL1 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 80%9672383 Defective factor IX causes thrombophilia F8 F10 F9 CELL DIVISION%REACTOME%R-HSA-68884.3 cell division KIF20A RAD21 PLK1 SMC1A PDS5B PDS5A NIPBL WAPL MAU2 STAG1 STAG2 KIF23 SMC3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.4 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGKV1-17 CD79B IGKV1-12 ORAI2 CD79A IGHV3-7 ORAI1 IGHV3-9 BTK PIK3CD IGHV3-30 ITPR1 ITPR2 ITPR3 IGHV3-33 IGKV1D-39 IGKV1D-33 CD19 IGKV2D-28 IGKV4-1 SH3KBP1 IGHV7-81 PIK3AP1 IGKV2D-30 IGHV4-59 PLCG2 IGHV1-69 SYK CALM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PTPN6 IGKV3-15 IGKV3-11 LYN IGHM IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 BLNK BLK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 TRPC1 IGLC1 IGLC2 IGHD IGKV3D-20 FYN IGLV3-19 VAV1 IGKV2-30 PIK3R1 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 SOS1 IGKC IGKV1-39 IGLV3-21 IGKV1-33 DAPP1 NCK1 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 CD22 IGLC6 IGHV3-23 AHCYL1 IGLV IGLV2-8 STIM1 IGKV1-16 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 80%171306 Packaging Of Telomere Ends H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.3 Defective GALT can cause GALCT GALT SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 80%9703465 Signaling by FLT3 fusion proteins ZMYM2 PIM1 MYO18A GOLGB1 GAB2 TRIP11 NOX4 PIK3R1 NRAS PIK3CA SOS1 SPTBN1 HRAS STAT5A STAT5B CDKN1A ETV6 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 80%73929 Base-Excision Repair, AP Site Formation H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 NTHL1 H2AC7 MPG H2BC17 H2BC12 H2BC13 MBD4 H2BC14 SMUG1 H2AJ H2BC15 NEIL2 H2BC11 NEIL1 OGG1 H2AZ1 H2BC9 H2AZ2 TDG ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 MEIOSIS%REACTOME%R-HSA-1500620.2 Meiosis MLH1 RAD51C LMNB1 SMC1A H3C15 CDK4 CDK2 BLM RPA2 MRE11 RPA3 RAD21 SYCP2 SYCP1 SYNE2 SYNE1 SUN2 SUN1 TEX12 SMC1B HSPA2 SYCE3 SYCE2 SYCE1 REC8 SPO11 BRCA2 STAG3 TEX15 SYCP3 MSH4 MSH5 FKBP6 UBE2I RPA1 DMC1 ATM PSMC3IP RBBP8 NBN MND1 MLH3 STAG1 STAG2 TOP3A RAD50 RAD51 H2AX H3-3B H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 PRDM9 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 ATR H2AC20 H3C8 BRCA1 SMC3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 80%428890 Role of ABL in ROBO-SLIT signaling ABL2 ABL1 CLASP2 CLASP1 ROBO1 CAP2 CAP1 SLIT2 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.2 XAV939 stabilizes AXIN TNKS TNKS2 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 80%1236394 Signaling by ERBB4 ITCH SRC NRG1 ESR1 DLG4 GABRB3 GABRB2 NEDD4 GABRB1 WWP1 CXCL12 GABRG3 GABRG2 GABRQ GABRA1 PGR WWOX TAB2 NCOR1 SHC1 EGF UBA52 PIK3R1 SPARC EGFR NRAS CSN2 PIK3CA STMN1 ADAP1 SOS1 MXD4 HRAS BTC NRG3 NRG4 NRG2 HBEGF EREG UBB UBC RPS27A APH1A PSENEN APH1B PSEN2 ADAM17 GFAP S100B STAT5A YAP1 PSEN1 NCSTN APOE COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 80%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6B AGO3 AGO4 AGO1 TNRC6C AGO2 MOV10 TNRC6A INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.2 Intracellular oxygen transport NGB CYGB MB DISEASE%REACTOME DATABASE ID RELEASE 80%1643685 Disease NUP62 NUP214 NDC1 RDH5 SEC13 NUP210 HSPA1A NUP133 PARP1 PYCARD NUP93 NUP50 NUP54 NUP205 POM121 BLM AAAS NUP160 HDAC7 WRN POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 XRCC4 NUP155 CDKN2A RPA1 NUP153 PML IMPDH1 IMPDH2 NUP35 NUP37 B2M MUCL1 MAOA CARS1 BTC NRG3 NRG4 NRG2 IL17RC HBEGF EREG IL17RA MTRR MMAA MMAB MTR MMUT MMACHC MMADHC NCBP1 NCBP2 ELMO1 CSF2RB CSF2RA RFC5 RFC3 RFC4 LIG1 S1PR1 RFC2 RPA2 RPA3 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51D RAD50 RAD51 GOLGA2 DNMT3A CDC25B PRDX2 PRDX1 SLC7A9 SLC3A1 CCNK FGF1 HUS1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 RHNO1 FGF10 GNS ATRIP GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 RAD17 ATR ERCC3 ELL ERCC2 TAF7L ELOA PMS2 TAF9B MLH1 TCEA1 RAD1 CCNT2 YWHAB CCNT1 AKT2 MLST8 SUPT16H AKT1 MSH2 CYP17A1 CYP19A1 RPS6 TSC2 MTOR FKBP1A AKT1S1 ELOA2 CDK9 TAF4B SFTA3 RAD9B TGFB1 SFTPB RAD9A TGFBR1 SFTPC TGFBR2 ITGB1 ALDOB NCKAP1 DCXR CYFIP1 SFTPA2 SFTPA1 TOPBP1 BRK1 TAF9 TAF1L TAF15 TAF12 TAF13 TAF10 TXNRD1 TAF11 SSRP1 TAF7 TAF6 TAF5 TAF4 GCKR TAF3 TAF2 TAF1 CYBA VAV2 BCR RAB7A NOXO1 PIK3R2 SYT1 NCKAP1L WASF1 WASF2 JAG1 LIG4 CAV1 SLC17A5 RNF5 BAIAP2 RNF185 ABI2 ENTPD1 ABI1 NOXA1 GNE NOX1 ENTPD5 S100A9 S100A8 RHAG SLC4A1 LTF SLC34A3 SLC34A2 SLC34A1 FKBP4 HDAC6 FGF16 FGF7 FGF18 PTGES3 PPP2R5D DUSP6 DUSP7 DDX5 PPP2R1B APC AXIN1 GTF2A1 KANK1 C1QBP GTF2A2 FGB FGA VWF F10 GP1BB F12 F11 FGG GP1BA F2 GP5 GP9 F8 F9 SERPING1 WDR48 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X HEPH RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 SLC39A4 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPS10 SLC11A2 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 EEF1G RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 SLC2A9 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A AMER1 RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A EEF2 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 FEN1 H3-3B CHST3 MSH6 NOTCH2 NOTCH3 NOTCH4 DNA2 PRIM2 PRIM1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLA1 POLA2 PPP2R5E PTGIR PPP2R5B PPP2R5A PPP2R5C FGR BANF1 HMGA1 PSIP1 PACS1 RANBP1 ITPR1 ITPR2 ITPR3 NOS2 NTHL1 MAPK14 P2RX7 DERL3 ERLIN1 P2RX4 EML4 PTPN6 IRAK1 RCC1 RAN ACY1 KPNB1 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 SMAD2 SMAD3 KDM1A KIF5B ABCB4 KLC1 PHF21A PDCD6IP ABL1 ETV6 GOLGA4 FIP1L1 CDK5 RAB5A CYP7B1 ABCB11 RCOR1 CYP27A1 ARID4A COMT CYSLTR1 FNTA FNTB SIGMAR1 ATP1B3 ATP1B2 ATP1B1 BRMS1 ATP1A4 ATP1A3 HMG20B ATP1A2 ATP1A1 H3C8 BRD4 CRBN FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 NFE2L2 RAD51B RAD51C HEY1 HEY2 HES5 HEYL DOCK2 DOCK1 HDAC2 H3C15 VPS45 TCF7L2 MYC CTNNB1 KCNJ11 ABCC8 ABCC9 VPS33B CORO1A HGS KPNA1 MDM2 ATM KIT HK1 CLTC CLTA ZDHHC8 CUBN AMN SAR1B ABCA1 SPON2 SEMA5B SPON1 THSD7B B3GLCT THBS2 ADAMTS12 FMO3 IRAK2 THBS1 THSD1 THSD4 ADAMTS10 ADAMTSL1 ADAMTS15 ADAMTS2 ADAMTS14 ADAMTS3 ADAMTS13 IL10 ADAMTSL5 IL6 ADAMTSL4 CD163 ADAMTS19 PLK2 ADAMTSL3 RHBDF2 ADAMTSL2 MYH9 ADAMTS17 THSD7A ADAMTS6 HEXB ADAMTS7 HEXA SBSPON SSPOP ADAMTS20 NMT1 TJP1 NEU1 ARSB CTSA FZD7 SLC22A18 GLB1 SV2C SV2B SV2A VAMP1 ST6GALNAC2 RPN2 TUSC3 ZDHHC20 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 GOLGA7 ST3GAL2 ST3GAL3 ST6GAL1 NEIL1 EDEM2 MOGS ABCC6 ZDHHC11 DDOST HNRNPK MGAT4C ZDHHC9 DAD1 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 APH1A PSENEN APH1B PSEN2 B4GALT1 ZCRB1 SLC35D1 SLCO1B1 CPSF4 SLCO1B3 SLC35A2 SLC35A1 SLC35A3 SLC33A1 SLC35C1 SLCO2A1 AVP SLC25A5 SLC25A4 SLC29A3 SLC25A6 SLC27A4 PABPN1 ROCK1 MUC13 GGCX EPM2A GBE1 GAA G6PC1 GYS2 GYS1 G6PC3 PPP1R3C NHLRC1 GYG2 ABCA12 SLC37A4 GYG1 ABCB6 FLT3 GSK3A BAD CASP9 AKT3 SLC9A6 SLC9A9 ZBP1 MAP2K4 PLCG2 MAP2K7 JUN VAV3 SYK MAPK8 SLC4A4 IRS2 SLC6A19 SLC12A6 SLC6A18 SLC6A14 SLC26A2 SLC1A1 SLC6A20 SLC1A3 SLC6A2 SLC6A3 SLC6A5 SLC5A5 CASP1 SLC26A4 SLC26A3 CYFIP2 WIPF1 WIPF2 SLC7A7 WIPF3 SLC24A1 GJA1 SLC24A4 SLC20A2 SLC3A2 FRS2 FRS3 DYNC1LI1 DYNC1LI2 SLC17A8 SLC12A3 IQGAP1 SLC12A1 SLC24A5 SFN WNT5A ARPC1B ARPC1A FZD5 FZD4 FZD6 DYNLL2 CHMP1A CBX1 PPP1CC TENT4A DUSP16 KIAA1549 DUSP10 MPRIP AGTRAP TPM4 TPM3 AP3B1 DUSP8 DUSP9 CDC25C SND1 MRAS KDM7A FAM114A2 ZC3HAV1 PAPSS1 FXR1 LMNA SHOC2 QKI CLCN6 FAM131B AGGF1 DVL1 DVL2 DVL3 ARPC4 ARPC5 ARPC2 ARPC3 MAP3K11 NCK1 ACTR3 ACTR2 RANGAP1 PIK3C3 ROCK2 CSK WASF3 GALE BTK GALNT12 CFTR POMT2 POMT1 LFNG C1GALT1C1 LARGE1 POMGNT1 PIK3R4 PIK3R3 C1GALT1 B4GAT1 SHH IHH SPTBN1 STAM PTK2 WASL XPO1 HDAC4 RAC2 RHOG WAS TRAK1 DYNC1I1 MYO9B ACTG1 ELMO2 STAM2 NCKIPSD TPMT H2AW HDAC10 H2AC17 LMNB1 H2AC12 H2AC1 YWHAQ H2BC18 HDAC8 H2AC21 YWHAH YWHAZ GCLC NOX4 GCLM MAP1LC3B VHL MAP2K1 YES1 ADRB1 ADRB2 HTR4 TAAR3P HTR6 HTR7 HRH2 DRD1 DRD5 TAAR8 TAAR9 TAAR6 TAAR5 TAAR2 TAAR1 ADRB3 KLB GTF2F1 GTF2F2 DERL1 ESRP1 GALNT3 FGF19 FGFR4 CD4 PAH GEMIN2 ABCG8 SNRPD2 ABCG5 SNRPD1 SNRPD3 GEMIN4 SNRPG ATIC GEMIN5 GEMIN6 SNRPE GEMIN7 SNRPF GEMIN8 SNRPB ABCA3 UVRAG DDX20 SMN2 CCNH ARID4B DNMT3B TBP SAP30 NUS1 DHDDS MSH3 DNMT1 SAP30L AVPR1B SAP18 AVPR1A SUDS3 CDK7 MNAT1 GALNT1 ABCD1 TSG101 VPS4B VPS4A MVB12B MVB12A GGT1 VPS36 VTA1 VPS37C VPS37D VPS37A SNF8 VPS37B CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 UBAP1 CHMP4A CHMP6 CHMP7 VPS25 GGT5 VPS28 CHMP5 SLC40A1 CP CYP26C1 KHK IPO5 GRSF1 DNAJC3 UGT1A1 SLC16A1 PGK1 ENO1 MAT1A TPST2 TPST1 TUFM OPLAH AHCY PAPSS2 SEL1L DERL2 ERLEC1 OS9 SYVN1 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE SUPT5H CDC25A IRS1 PIK3CD PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG GAB2 MET PDGFB TGFA CD19 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 TMPRSS2 ACE2 PRMT1 GFPT1 FOXO3 ELK1 CREB1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 GOLGB1 APRT ALG11 PNP HPRT1 ADA PHB1 ITGB3 ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B NMT2 RAP1A MARK3 BRAP GALT MAP2K2 SRD5A3 KSR1 FN1 MPI PMM2 KSR2 CNKSR2 DOLK GALK1 APBB1IP CNKSR1 KRAS TLN1 RAF1 VCL SGSH HDAC11 NAGLU IDS GUSB HDAC9 B4GALT7 IDUA BCL2A1 B3GAT3 ZC3HC1 EXT1 EXT2 GTF2B GTF2E1 GTF2E2 RNMT RNGTT SLC2A10 ALG2 CTNND1 CBLL1 DPM1 DPM2 DPM3 CYP11A1 FDX1 FDX2 FDXR CYP11B2 CYP21A2 AHCYL1 TRIM27 MAPKAP1 EZH2 SLC5A2 PRKX RICTOR MBD3 SUZ12 GATAD2B GATAD2A KPNA2 TNKS FOXO6 FOXO4 FOXO1 NR4A1 MYD88 PRR5 PTEN CHD4 CHD3 DPAGT1 ALG8 EED ALG9 IRAK4 ALG6 HDAC5 ALG14 MTA1 ALG13 ALG3 TNKS2 MTA2 ALG12 ALG1 MTA3 CHST14 REST MPDU1 RFT1 RPS6KB2 CHSY1 BAG4 ZMYM2 CUX1 FGFR1OP2 MYO18A TRIM24 LRRFIP1 CPSF6 STAT1 ERLIN2 FGFR1 SMAD4 TICAM1 TLR3 ARF1 MCCC2 MCCC1 JAK1 MSN TYK2 SOD2 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 SRPK2 SRPK1 SFTPD PPIA NLRP12 CRB3 ALK VPS33A ABCC2 G3BP1 G3BP2 PALS1 CNBP VPS41 IL1R1 SQSTM1 GSDMD RIPK2 IL18 IL1A IL1B NOD1 NOD2 PTPN12 CYP1B1 CALR IL6R CEBPB SFPQ PORCN DHH WNT3A OGG1 DKK1 DKK2 DKK4 FZD8 KREMEN1 KREMEN2 RNF43 LRP5 LRP6 SH3GL3 PC BTD PCCA HLCS PCCB ACACA MYO10 CCNC HHAT SLC22A5 SLC22A12 STX1B STX1A TFG CD36 GCK SH3GL2 GCC2 HIP1 ELOB ELOC EPS15 TRIP11 SH3GL1 SEMA5A IAPP SYT2 CDK8 CEBPD DAG1 OPN1LW OPN1MW SH3KBP1 CXCR4 CDK5R1 OPN1SW SLC2A2 CYP11B1 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB GPR83 GPR84 CRHR1 CRHR2 GHRHR MC2R CALCR CGA GPR15 CBLIF MC1R RLN2 RLN3 GPR27 TCN2 GLP1R CD320 GPR25 ABCD4 GPR20 ADM PTH1R MC4R INSL3 TSHB GPR39 GPR32 FSHB GLP2R LMBRD1 AVPR2 GPBAR1 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 P2RY11 SCTR GCG TSHR POMC GHRH ADM2 MC5R VIP RAMP1 GPHB5 CHST6 LUM OGN OMD KERA PRELP FMOD CYP27B1 CYP26B1 CYP24A1 CYP2R1 KEAP1 NEDD4L SI CAMK2B RNF213 LCT CAMK2D ATG7 GUCY2C SRC PDZD3 CD9 CAMK2A NRG1 CALM1 HYAL1 CAMK2G SLC5A7 SLC5A1 LMO7 CUL5 CYP2U1 DPEP2 DPEP1 AGK DPEP3 CYP4F22 TBXAS1 YWHAE PPP1CB PPP2R1A UNC93B1 LY96 CD14 S100A1 TIRAP BTRC PRKACA TLR1 TLR10 TLR6 TLR5 TLR4 YWHAG TLR2 SKP1 HSP90AA1 PPFIBP1 TUBB NR3C1 DYNLL1 AKAP9 UBA52 DYNC1I2 GSS CUL1 UBB CTBP2 CTBP1 PRKAR2B UBC RPS27A DYNC1H1 BCL2L11 CEP43 TRADD STAT5A STAT5B FASLG PTPN11 RBX1 JAK2 IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 C3AR1 PSMD1 IKBKG MAP3K7 CHUK TXNIP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 EIF2AK2 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 JAK3 PSMA7 RELA PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TBK1 STING1 NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X SLC36A2 SHC1 EGF GAB1 PIK3R1 CBL EGFR NRAS SNAP25 PIK3CA CDC37 PLCG1 SOS1 HRAS CAPNS1 CDH1 CAPNS2 PGM1 MBL2 BSG CAPN2 ITGA4 CAPN1 CAST MUC5AC ADAM10 BECN1 HSPG2 BCAN ADAM17 MYO1C PSEN1 ADAMTS16 PDCD1 NCSTN ADAMTS18 ADAMTS4 ADAMTS5 CTSL ADAMTS1 TRIM28 CTSG ADAMTS8 ADAMTS9 MYO5A DCN GRB2 FURIN MUC12 ACAN MUC15 KLKB1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 MUC3A H2BC17 MUC3B H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 MUC16 MUC17 RBBP4 MUC19 RBBP7 H2AZ1 H2BC9 H2AZ2 MUC20 MUC21 NPM1 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MUC5B GALNS SUGT1 IGHV3-23 AP1S2 UBE2D1 IGLV AP1S1 AP1S3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 ATG14 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 CFP V3-4 HMOX1 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 MRE11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IFNAR1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 AP1M2 V1-9 V5-4 AP1M1 V1-7 V5-1 V1-5 PDPK1 V1-3 IGKV3D-20 V5-6 BCL2L1 TRAF6 PSTPIP1 IGLV3-19 AP1G1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 CRK IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 TTR V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PRKAR2A GNAS HLA-H HLA-B GSK3B AP1B1 HLA-C HLA-A HLA-F HLA-G HLA-E FGFR3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 CREBBP NOTCH1 HCK MAML2 TLR9 TLR8 MAML1 TLR7 RBPJ KAT2B KAT2A SNW1 EP300 HES1 EIF2AK3 MAML3 MAMLD1 BIRC6 BCL11A FGFR2 RRBP1 TP53 WDCP SPRED3 SPRED2 SPRED1 CUL3 NLRP3 IDH1 NF1 C3 HGSNAT UBE2I MYH2 SUMO1 IFNA5 IFNA4 APP IFNA7 IFNA6 HSP90AB1 IFNA2 MUC1 MUC2 MUC7 HMGB1 IFNA8 IFIH1 CASP8 MUC4 TRIM4 MUC6 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 TRAF2 SIKE1 IRF3 TRAF3 IRF7 IFNA10 RNF135 TKFC RIPK1 FADD IFNA21 IFNB1 ISG15 LRAT VAMP2 NFKB2 MAVS RB1 CDKN1C CDKN1A ANAPC15 CDKN1B ANAPC16 STAT2 ANAPC10 ANAPC11 RBP4 FZR1 CCND3 CDC23 PIM1 CCND2 KPNA7 CCND1 CDC26 KPNA4 CDC27 RBP1 KPNA5 E2F1 E2F2 E2F3 KPNA3 SKP2 DAXX ANAPC7 UBE2C ATRX UBE2E1 CDK6 RDH12 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 ABCA4 CDK2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SLC2A1 FCGR3A BRAF PPP2CA PPP2CB NAPEPLD PPM1B MAPK1 SEC23A MAPK3 FCGR1A SEC24B SEC24A NEIL3 FCGR2A SEC24D SEC24C TALDO1 RPIA CD86 CDC42 LCK CD80 CD28 FYN RAC1 PAK2 VAV1 SEC31A XRCC6 VCP XRCC5 SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 CD3G GPC5 CSPG4 GPC4 AGRN GPC6 CCR5 STRA6 RLBP1 APOA1 ACTB IL17F IL17A GNG10 MASP1 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 DCTN1 JUNB GNG3 GNG2 BIN2 GNG5 GNG4 MEFV GNG7 GNG8 STAT3 ERBB2 ERBIN UGT1A4 CD8B AP2S1 GSDME ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 KDR MRC1 IFNGR1 NUP107 NUP188 IFNGR2 BRCA1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.2 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 80%1489509 DAG and IP3 signaling ADCY3 PRKCG ADCY2 PRKCA ADCY1 PRKCE ADCY8 CAMK4 PDE1C PDE1B ADCY7 PDE1A ADCY6 ITPR1 ADCY5 ITPR2 CAMK2B ITPR3 CAMK2D CAMK2A PLCG1 PRKX PRKCD CAMKK1 CAMKK2 CREB1 PRKAR2B CALM1 CAMK2G PRKACG PRKACB KPNA2 ADCY9 GRK2 PRKAR1B PRKAR1A NBEA PRKAR2A PRKACA AHCYL1 ADCY4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.6 Peptide ligand-binding receptors CCL19 CCL22 CCL20 AVP OPRD1 CXCR1 CXCR2 CXCL6 CXCL9 CXCL13 CXCL3 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 XCL2 C5AR2 XCL1 C5AR1 CX3CR1 CCL13 CXCR5 CXCR6 CCL7 CXCR3 CCL1 CCL17 CCL16 CCR10 CCL25 XCR1 CCL21 CXCL11 CXCL8 ACKR4 ACKR3 ACKR2 CCL28 CXCL1 CCL27 CXCL2 OPRM1 C3 APP NPFFR2 NPFFR1 RXFP4 GRPR RXFP3 HEBP1 EDNRA ANXA1 EDNRB MT-RNR2 FPR1 PROK2 FPR3 PROK1 FPR2 OXTR UTS2R AVPR1B NPFF OXT GPR37L1 C5 AVPR1A PDYN TRHR UTS2B KEL AGTR2 NLN GALR3 GALR2 GALR1 NPBWR1 NPBWR2 PPY HCRT NTSR1 NTSR2 NMB NMBR SAA1 NMS NMU PNOC QRFP MLN BRS3 CCKAR C3AR1 EDN1 GPR37 EDN2 EDN3 TACR2 TACR3 GAL CCKBR NPB PROKR1 CXCL10 PROKR2 NPW KISS1R PRLH AGT CCL5 XK F2RL1 CCL4 F2RL2 CCL3 F2RL3 CCL2 PMCH NPY2R GHSR CXCR4 NPY1R APLNR UTS2 NTS MCHR2 TAC3 TAC1 PYY NMUR2 NMUR1 MLNR ECE1 ECE2 TRH BDKRB2 BDKRB1 CCR1 PRLHR QRFPR INSL5 NPY5R SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 OPRK1 CCK HCRTR2 HCRTR1 APLN KISS1 CCR6 ACKR1 CCR5 CCR2 SST RXFP1 RXFP2 GRP CXCL12 PPBP MC2R PSAP MC1R RLN2 RLN3 CCL3L3 MC4R GPER1 INSL3 KNG1 AVPR2 MC3R F2R NPSR1 F2 PENK SSTR3 NPS PF4 POMC MC5R AGTR1 MCHR1 NPY TACR1 CCL11 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.2 Translation of Structural Proteins GSK3A CSNK1A1 UBE2I SUMO1 PRMT1 ST6GALNAC2 RPN2 TUSC3 ZDHHC20 PRKCSH ZDHHC8 RPN1 ZDHHC5 MAGT1 ZDHHC2 UBA52 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 GOLGA7 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS UBB PARP10 PARP6 ZDHHC11 PARP4 DDOST PARP16 MGAT4C PARP9 UBC ZDHHC9 DAD1 PARP14 PARP8 MGAT4A CANX RPS27A MGAT4B STT3A MAN1B1 GALNT1 ST6GALNAC3 ST6GALNAC4 SRPK2 SRPK1 GSK3B DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME%R-HSA-5579031.4 Defective ACTH causes obesity and POMCD MC2R POMC CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 80%156584 Cytosolic sulfonation of small molecules PODXL2 SULT1A4 SULT1C2 SULT1A3 SULT4A1 SLC35B3 SLC35B2 ABHD14B PAPSS2 SLC26A2 SLC26A1 BPNT2 BPNT1 TPST2 TPST1 SULT6B1 SULT1C4 SULT2A1 PAPSS1 SULT1A2 SULT1E1 SULT1B1 SULT1A1 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 80%5635838 Activation of SMO SMO GRK2 CSNK1A1 CDON DHH KIF3A SHH PTCH1 BOC IHH GAS1 ARRB1 ARRB2 EFCAB7 IQCE EVC GAS8 EVC2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 80%72731 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 EIF2S3 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 80%9018676 Biosynthesis of D-series resolvins HPGD ALOX5 LTA4H G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 80%397795 G-protein beta:gamma signalling GNGT2 PLCB3 CDC42 BTK PLCB1 PAK1 PLCB2 PDPK1 PIK3CG AKT3 PIK3R5 PIK3R6 AKT2 GNG3 AKT1 GNG2 GNG5 GNG4 GNG7 GNG8 RHOA GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 ARHGEF6 GNGT1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 80%9619229 Activation of RAC1 downstream of NMDARs CAMKK1 CAMKK2 CAMK1 RAC1 CALM1 GIT1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.2 Negative regulation of FGFR1 signaling UBA52 CBL FRS2 FGF1 FGF2 FGF3 FGF4 UBB FGF6 ANOS1 FGF9 FGF20 UBC FGF23 BRAF PPP2CA FGF22 PPP2CB FGF10 MKNK1 RPS27A MAPK1 SPRY2 MAPK3 PPP2R1A PTPN11 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 80%1834941 STING mediated induction of host immune responses PRKDC IFI16 TREX1 CGAS XRCC6 XRCC5 NLRC3 NLRP4 DTX4 TRIM21 TBK1 IRF3 STING1 STAT6 DDX41 MRE11 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.2 Synthesis of UDP-N-acetyl-glucosamine UAP1 AMDHD2 GFPT1 GFPT2 PGM3 GNPNAT1 RENBP NAGK MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 80%2206290 MPS IV - Morquio syndrome A GALNS SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.2 SHC1 events in EGFR signaling EPGN SOS1 HRAS BTC AREG SHC1 EGF HBEGF EREG TGFA EGFR NRAS DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 80%3359463 Defective CUBN causes MGA1 CBLIF CUBN AMN DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 80%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.1 Lactose synthesis LALBA B4GALT1 SLC2A1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.2 TGFBR2 Kinase Domain Mutants in Cancer TGFB1 TGFBR1 TGFBR2 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 80%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MECR HADHB HADHA ECHS1 ACADM HADH GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 80%8856688 Golgi-to-ER retrograde transport NSF KIF6 COPZ1 KIF27 KIF9 PAFAH1B3 KIFC2 ARF5 KIF2A KIFC1 NBAS KIF2C KIF2B ARCN1 CENPE RINT1 KIF26A CAPZA1 KIF26B CAPZA2 RAB6B PAFAH1B2 SEC22B BICD1 BICD2 ARFGAP1 RAB6A ARF3 RAB1A RAB1B PLA2G6 KDELR1 SURF4 TMED2 ARFGAP3 RAB18 ARFGAP2 KDELR2 KDELR3 KIF3A PLA2G4A RACGAP1 TMED3 TMED7 TMED9 NAPB AGPAT3 ZW10 STX18 NAPG RAB3GAP2 COPG2 COPG1 RAB3GAP1 CAPZA3 COPB2 COPA TMED10 COPB1 ACTR1A KIF28P COPE USE1 KIF5C KIF5B KIF5A KIF21A KIF21B KIFAP3 KIF16B KIF20A KIF20B DYNLL1 ARF4 DYNC1I1 DCTN6 DCTN5 KLC1 DCTN1 BNIP1 ACTR10 DCTN4 KLC4 KLC3 KLC2 GALNT2 KIF3B PAFAH1B1 NAPA DYNC1I2 DCTN2 KIF3C DCTN3 ARF1 DYNC1LI1 DYNC1LI2 KIF18A KIF18B KIF4B KIF4A GALNT1 DYNC1H1 GBF1 KIF12 KIF11 KIF15 KIF19 CAPZB KIF13B KIF1C KIF1B KIF1A COPZ2 KIF25 KIF23 DYNLL2 KIF22 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 80%1834949 Cytosolic sensors of pathogen-associated DNA IKBKB PRKDC IKBKG CREBBP CHUK ZBP1 NLRP4 EP300 DTX4 DHX9 MRE11 RELA CTNNB1 IFI16 TRIM32 TREX1 MYD88 NFKB1 CGAS NFKBIA CRCP AIM2 NFKBIB TBK1 STING1 STAT6 DDX41 POLR3GL LRRFIP1 DHX36 UBA52 NKIRAS1 NKIRAS2 XRCC6 POLR1C XRCC5 POLR1D TICAM1 TLR3 NLRC3 UBB POLR2E POLR3A IRF3 POLR2F POLR3B POLR3C IRF7 POLR2H POLR3D UBC POLR3E POLR2K POLR3F RPS27A POLR2L POLR3G POLR3H POLR3K TRIM56 RIPK1 RIPK3 NFKB2 TRIM21 DIGESTION%REACTOME DATABASE ID RELEASE 80%8935690 Digestion CHIT1 CLPS PNLIP CHIA AMY2A AMY1A AMY2B AMY1B SI TREH AMY1C LCT GUCY2C PNLIPRP1 PNLIPRP2 GUCA2B CEL GUCA2A ALPI LIPF MGAM PIR PNLIPRP3 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 80%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CTNNB1 EP300 LRRFIP1 CREBBP IRF3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 80%15869 Nucleotide metabolism GMPS NME1 GUK1 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 NUDT16 NUDT5 NUDT15 ADPRM NT5C NT5C2 AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 DTYMK TYMP AK1 AK2 AK4 UCKL1 GLRX UCK2 AK5 UCK1 AK6 PUDP TK2 AK7 AK8 AK9 NME2P1 NUDT13 RRM1 NME3 ADSL CTPS2 CAD NME4 CTPS1 PAICS PFAS DCTD CMPK1 DHODH ATIC DCTPP1 PPAT IMPDH1 IMPDH2 ADSS1 GDA ADSS2 DNPH1 UMPS GART NT5C1B ITPA RRM2B TXNRD1 TK1 TYMS SAMHD1 RRM2 NME2 GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP HPRT1 ADA XDH CDA DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME DATABASE ID RELEASE 80%5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR1B AVPR1A INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 80%9012546 Interleukin-18 signaling IL37 IL18RAP IL18BP IL13 IL18 IL18R1 ALOX5 IL4 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 80%174490 Membrane binding and targetting of GAG proteins UBAP1 RPS27A VPS28 UBA52 TSG101 MVB12B MVB12A VPS37C VPS37D NMT2 VPS37A VPS37B UBB UBC PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RPS27A AKT1 PTK6 UBB DOK1 UBA52 ARAP1 CBL UBC DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 80%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.1 SARS-CoV-2-host interactions RPS11 RPS10 ATG14 RPS13 RPS12 NUP62 NUP214 RPS9 NDC1 RPS7 SEC13 RPS8 NUP210 RPS5 NUP133 RPSA RPS3A YWHAQ NUP93 UBE2V1 YWHAH NUP50 NUP54 NUP205 POM121 RPS4Y2 AAAS NUP160 YWHAZ RPS27L RPS4Y1 POM121C RPS15A NUP42 NUP85 RPS3 RPS2 TPR NUP88 NUP43 RAE1 RANBP2 MAP1LC3B NUP155 RPS26 UBE2N RPS25 TAB3 RPS28 TAB2 RPS27 TAB1 RPS29 NUP153 IFNAR1 RPS20 FAU RPS21 RPS24 NUP35 B2M RPS23 NUP37 PDPK1 TRAF6 IL17RC IL17RA HLA-H HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E AKT3 CREBBP TLR8 TLR7 YWHAE KPNA2 PTPN6 IRAK1 NLRP3 GEMIN2 TLR1 SNRPD2 SNRPD1 SNRPD3 YWHAG TLR2 GEMIN4 SNRPG HSP90AA1 GEMIN5 GEMIN6 SNRPE GEMIN7 IFNA5 SNRPF IFNA4 GEMIN8 SNRPB UVRAG DDX20 IFNA7 IFNA6 SMN2 HSP90AB1 IFNA2 IFNA8 IFIH1 STAT1 TRIM4 GJA1 TRIM25 IKBKE TOMM70 IFNA13 IFNA14 IFNA16 DDX58 IFNA17 SIKE1 IRF3 TRAF3 IRF7 IFNA10 JAK1 RPS27A RNF135 TKFC TYK2 PATJ SFN VPS39 VPS18 IFNA21 LARP1 VPS11 IFNB1 VPS16 ISG15 SFTPD NLRP12 MAVS CRB3 VPS33A G3BP1 PTPN11 G3BP2 PALS1 CNBP VPS41 STAT2 IKBKB IKBKG MAP3K7 CHUK YWHAB AKT2 RIPK2 AKT1 NOD1 NOD2 RPS6 VPS45 SEC23A VPS33B SEC24B SEC24A SEC24D SEC24C TBK1 STING1 TUFM SAR1B MBL2 IRAK2 PIK3C3 BECN1 CAV1 PIK3R4 TJP1 IL17F IL17A MASP1 RPS4X RPS15 RPS14 RPS17 RPS16 RPS19 NUP107 RPS18 NUP188 TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 80%804914 Transport of fatty acids LCN12 SLC27A6 APOD LCN9 SLC27A1 SLC27A4 LCN15 LCN1 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 80%2025928 Calcineurin activates NFAT PPP3CA FKBP1A PPIA PPP3CB NFATC3 NFATC2 PPP3R1 NFATC1 CALM1 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013106 RHOC GTPase cycle CIT VANGL1 ARHGAP32 DIAPH3 DIAPH1 PKN3 ARHGEF10L MCF2L STX5 FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 ANLN PKN2 AKAP13 PKN1 CCDC187 STK10 SLK RHOC STOM ARHGEF1 ROCK1 TFRC FMNL3 ARHGEF5 FLOT2 FMNL2 ARHGAP1 C1QBP VAPB ARHGAP39 ARHGAP5 ARHGAP35 PREX1 OPHN1 CAVIN1 PIK3R1 MYO9B LBR DLC1 TMPO RTKN VAV2 BCR DEPDC1B DAAM1 ARHGEF40 VAMP3 ARHGDIA IQGAP1 RHOA IQGAP3 ERBIN ROCK2 LMAN1 ARHGEF25 ABR ARHGEF28 ARHGAP21 ARHGAP18 RACGAP1 STARD13 JUP ACBD5 CAV1 MCAM MCF2 MACO1 ARHGAP26 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%9640463 Wax biosynthesis AWAT2 FAR2 AWAT1 FAR1 KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 80%9755511 KEAP1-NFE2L2 pathway PSMD8 PSMD9 PSMD6 NFE2L2 PSMD7 PSMD4 PSMD5 GSTA1 PSMD2 HMOX1 PSMD3 PSMD1 SQSTM1 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SESN2 PSMA2 AKT2 PSME3 PSME4 PSME1 AKT1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYC BACH1 PSMB10 PSMA8 SESN1 PSMB6 MUL1 PSMB7 PSMB4 PSMB5 GCLC PSMB2 NPLOC4 PSMB3 PSMB1 PSMF1 GCLM SRXN1 PSMB8 MAP1LC3B PSMB9 ME1 CSNK2A1 SEM1 UBXN7 UFD1 CDKN2A PSMC5 CSNK2A2 PSMC6 PSMC3 G6PD PSMC4 PSMC1 PSMC2 TALDO1 PGD CSNK2B FBXL17 TKT GSTA3 TXNRD1 VCP GSK3B NQO1 AKT3 CREBBP NOTCH1 EP300 CUL3 IDH1 BTRC SKP1 ATF4 SLC7A11 PRDX1 UBA52 PRKCD CUL1 UBB UBC MAFG RPS27A MAFK KEAP1 TRIM21 RBX1 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 80%69478 G2 M DNA replication checkpoint CDK1 CCNB2 CCNB1 WEE1 PKMYT1 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 80%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 80%349425 Autodegradation of the E3 ubiquitin ligase COP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 COP1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ATM PSMC2 UBA52 UBB UBC RPS27A NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.1 NOTCH3 Intracellular Domain Regulates Transcription PLXND1 WWC1 HEY1 HEY2 FABP7 HES5 STAT1 DLGAP5 PTCRA CREBBP HEYL NOTCH3 NOTCH1 MAML2 MAML1 RBPJ KAT2B PBX1 KAT2A SNW1 EP300 HES1 MAML3 MAMLD1 MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 80%203927 MicroRNA (miRNA) biogenesis POLR2J POLR2K POLR2L BCDIN3D AGO3 PRKRA AGO4 AGO1 DROSHA RAN AGO2 DICER1 DGCR8 TARBP2 XPO5 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 80%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 80%9656255 Defective OGG1 Substrate Binding OGG1 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 80%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NKX2-2 INSM1 PAX4 NEUROG3 NEUROD1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.1 Retinoid metabolism disease events RBP4 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.2 Defective SLC34A2 causes PALM SLC34A2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 80%381042 PERK regulates gene expression ASNS EXOSC2 IGFBP1 EXOSC1 HSPA5 CEBPG CXCL8 EIF2AK3 HERPUD1 KHSRP EIF2S2 EIF2S1 CCL2 EIF2S3 DIS3 CEBPB DCP2 PARN EXOSC7 NFYA EXOSC6 NFYB ATF3 EXOSC5 DDIT3 EXOSC4 NFYC EXOSC9 ATF6 EXOSC8 ATF4 EXOSC3 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.1 AXIN missense mutants destabilize the destruction complex PPP2CA PPP2CB AMER1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HEY1 HEY2 HES5 CREBBP HEYL NOTCH1 MAML2 HDAC10 MAML1 HDAC11 HDAC2 RBPJ HDAC8 KAT2B KAT2A SNW1 EP300 HDAC9 HES1 MAML3 MAMLD1 HDAC6 HDAC7 MYC HDAC4 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SKP1 HDAC5 CCNC NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X UBA52 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 ADAM17 PSEN1 RBX1 JAG1 NCSTN SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.2 Signaling by Retinoic Acid CPT1A RDH5 DHRS3 CYP26C1 DHRS9 RXRB RARB RDH11 RDH10 RDH16 ADH1A PDHB AKR1C3 ADH4 PDK4 PDK3 ADH1C DLAT FABP5 PDK2 PPARD PDK1 ALDH1A1 PDHX PDHA2 PDHA1 CYP26A1 CYP26B1 CPT1B CRABP2 CRABP1 RDH14 RARA RDH13 DHRS4 SDR16C5 DLD RXRA ALDH1A3 ALDH1A2 ALDH8A1 RARG RXRG SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 80%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SNRPD3 SLBP ZNF473 LSM10 LSM11 SNRPG SNRPE NCBP1 NCBP2 SNRPF SNRPB DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 80%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 80%3359457 Defective CBLIF causes IFD CBLIF INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 80%448706 Interleukin-1 processing RELA NFKB2 CTSG IL18 IL1A IL1B GSDMD CASP1 NFKB1 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 80%75102 C6 deamination of adenosine ADARB1 ADAR DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.2 Diseases of Telomere Maintenance DAXX ATRX HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.1 HATs acetylate histones H2AW H2AC17 H2AC12 H2AC1 H2BC18 H3C15 H2AC21 KAT8 KAT7 SUPT20H ATXN7L3 KAT6A KAT14 TADA2A ZZZ3 SGF29 ING4 ING3 PAX3 SUPT3H TAF6L BRD8 BRPF1 ELP1 BRPF3 ELP2 ELP3 ELP4 ELP5 ELP6 JADE1 JADE3 PHF20 JADE2 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 ENY2 TAF5L MBIP DMAP1 DR1 MRGBP YEATS2 TADA1 VPS72 MSL2 MSL3 TAF9 RUVBL2 MSL1 KANSL1 ATXN7 KANSL2 KANSL3 TAF12 TAF10 TRRAP TADA2B TADA3 ATF2 YEATS4 EP400 CREBBP ACTB KAT2B KAT2A EP300 EPC1 NCOA2 USP22 KAT5 WDR5 HCFC1 ACTL6A H2AC19 SAP130 CLOCK H2AC14 MCRS1 H2BC21 RUVBL1 H2BU1 H2AC8 H2AC6 H2AC7 OGT H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RBBP7 H2BC9 MEAF6 H4C9 H2BC8 H2BC5 NCOA1 H2BC3 H2BC1 H2AC20 ING5 H3C8 BRD1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.4 SHC1 events in ERBB2 signaling PRKCA PTPN12 PRKCE ERBB2 SHC1 EGF EGFR NRAS NRG1 SOS1 PRKCD HRAS BTC NRG3 NRG4 NRG2 HBEGF EREG INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.1 Intestinal infectious diseases GUCY2C PDZD3 INFLAMMASOMES%REACTOME%R-HSA-622312.1 Inflammasomes HSP90AB1 RELA HMOX1 NLRP3 NLRP1 BCL2L1 PSTPIP1 NFKB1 TXNIP PYCARD NFKB2 AIM2 SUGT1 BCL2 MEFV P2RX7 PANX1 CASP1 APP NLRC4 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013408 RHOG GTPase cycle MPP7 VANGL1 ARHGAP32 DIAPH3 ESYT1 DOCK2 DOCK1 KALRN MCF2L STX5 LETM1 ARHGEF16 VAV3 NDUFS3 RHOG LAMTOR1 ITGB1 CYFIP1 TRIO HSPE1 TFRC ARHGEF5 ARHGAP1 VAPB ARHGAP39 ARHGAP5 ARHGAP35 CDC42 ANKLE2 PREX1 ITSN1 PLD1 OPHN1 STBD1 ARHGDIB PAK2 KTN1 VAV1 PIK3R1 EMD LBR MAP3K11 TMPO VRK2 LEMD3 VAV2 ARHGDIG PLEKHG3 DEPDC1B CDC42EP1 DSG2 ARFGAP3 RAB7A EPHA2 SHMT2 VAMP3 ARHGDIA GARRE1 IQGAP2 DOCK5 ELMO2 ERBIN DOCK4 DOCK3 ARHGEF26 LMAN1 ARHGAP21 PGRMC2 NDUFA5 YKT6 PAK4 CAV1 MCAM MCF2 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.2 Vpr-mediated nuclear import of PICs PSIP1 NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 KPNA1 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 BANF1 HMGA1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 80%1362409 Mitochondrial iron-sulfur cluster biogenesis ISCA1 FDX2 FDXR SLC25A28 HSCB GLRX5 LYRM4 FXN SLC25A37 ISCA2 FDX1 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 80%1236977 Endosomal Vacuolar pathway CTSL HLA-H HLA-B HLA-C HLA-A HLA-F CTSV HLA-G CTSS HLA-E B2M LNPEP ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 80%111447 Activation of BAD and translocation to mitochondria BID YWHAE BAD AKT3 SFN YWHAB PPP3CC YWHAQ YWHAG AKT2 YWHAH AKT1 BCL2 PPP3R1 YWHAZ AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.2 Aquaporin-mediated transport ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 RAB11FIP2 AQP1 MYO5B AQP8 AQP12A AQP10 AVP AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 GNG10 AQP3 MIP AQP11 GNG12 PRKACA GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 AVPR2 GNGT2 GNG3 GNG2 GNG5 GNG4 PRKAR2B GNG7 GNG8 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A RAB11A PRKAR2A GNAS ADCY4 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 80%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity NCOR1 HDAC1 UBE2D3 NEDD4L TGIF1 TGIF2 PARP1 UBA52 TRIM33 SMAD4 SMAD7 SNW1 SMURF2 UBB WWTR1 USP9X UBC RPS27A PPM1A ATP1B4 SMAD2 SMAD3 SKIL SKI UBE2D1 RNF111 NCOR2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.2 Condensation of Prophase Chromosomes H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 NCAPH2 NCAPG2 H2BU1 MCPH1 H2AC8 NCAPD3 H3C15 H2AC6 H2AC7 KMT5A H2BC17 H2BC12 H2BC13 H2BC14 SET H2AJ CCNB1 H2BC15 H2BC11 H2AZ1 H2BC9 SMC4 H2AZ2 SMC2 H4C9 H2BC8 H2BC5 H3-4 H2BC3 PLK1 H2BC1 H2AC20 CDK1 RB1 H3C8 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.5 Synthesis of Ketone Bodies AACS ACAT1 HMGCL ACSS3 BDH2 BDH1 HMGCS2 HMGCLL1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.2 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) HDAC1 H2AX H3-3B H2AB1 TTF1 H2AC19 H2AC14 H2BC12L H2BC21 HDAC2 H2BU1 H2AC8 H3C15 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 MBD3 H2AJ H2BC15 GATAD2B H2BC11 GATAD2A RBBP4 RBBP7 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CHD4 CHD3 H2AC20 MTA1 EHMT2 MTA2 MTA3 CBX3 H3C8 ERCC6 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.1 p130Cas linkage to MAPK signaling for integrins FGB FGA TLN1 VWF FGG SRC ITGB3 ITGA2B CRK RAP1B PTK2 RAP1A FN1 APBB1IP BCAR1 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 80%195721 Signaling by WNT NFATC1 CAMK2A TLE4 TLE2 TLE1 CALM1 WNT1 YWHAZ AMER1 CSNK2A1 CSNK2A2 CSNK2B PLCB3 PLCB1 AXIN2 H3-3B PLCB2 SCRIB VANGL2 TERT SMURF2 SMURF1 H3-4 WNT10B PPP2R5E GSK3B PRKG2 PPP2R5B PPP2R5A PPP2R5C CLTB ASH2L ITPR1 PIP5K1B CSNK1A1 ITPR2 ITPR3 CREBBP MOV10 XIAP EP300 RNF146 TNKS AGO3 CUL3 AGO4 PPP2R1A AGO1 AGO2 BTRC SKP1 KAT5 TNKS2 TNRC6C TNRC6A TNRC6B CSNK1E UBA52 TLE5 CUL1 RBBP5 UBB DAAM1 CTBP2 CTBP1 ZRANB1 UBC RPS27A SOX2 SOX9 GNAT2 PRKG1 WNT5A NLK WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 H3C8 RBX1 PDE6G FZD4 FZD6 GNAO1 PSMD8 PRKCG PSMD9 PRKCA PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 MAP3K7 PRKCB PSMA5 PSMA6 PSMA3 PSMA4 H3C15 PSMA1 PSMA2 AKT2 PSME3 PSME4 PSME1 AKT1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA TCF7L2 PPP2CB TCF7L1 MYC TCF7 PSMB10 PSMA8 LEF1 PSMB6 CTNNB1 RUNX3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 MEN1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DVL1 DVL2 VPS29 DVL3 WNT2B HDAC1 WNT8A CLTC WNT8B VPS26A SNX3 CLTA WNT6 PORCN VPS35 RAC1 WNT2 TMED5 RAC3 WNT3 WNT4 WLS WNT10A WNT5B WNT3A WNT7B WNT9B ROR1 WNT7A ROR2 WNT9A PRICKLE1 WNT16 TRRAP SOX3 FRAT1 FRAT2 SOX17 SOX6 SOX7 RHOA SOX4 SOX13 DKK1 DKK2 DKK4 SFRP1 SFRP2 HECW1 PARD6A FZD1 FZD8 RSPO2 RSPO3 RSPO1 RSPO4 KREMEN1 KREMEN2 WIF1 RYK LGR6 LGR5 CDC73 LGR4 USP8 RNF43 CAV1 CTNNBIP1 PYGO1 PYGO2 LEO1 KLHL12 CCDC88C BCL9L BCL9 CXXC4 CHD8 PFN1 USP34 CBY1 SOST DACT1 LRP5 LRP6 ZNRF3 KMT2D CSNK1G2 XPO1 RAC2 GNG10 GNG12 GNG11 PPP2R5D GNG13 PPP3CA TLE3 GNB2 PPP2R1B GNB1 SRY APC GNB4 FZD7 GNB3 AXIN1 GNB5 GNGT1 GNGT2 H2AX H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 RUVBL1 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 GNG3 H2AJ H2BC15 GNG2 H2BC11 GNG5 GNG4 PPP3R1 GNG7 GNG8 H2AZ1 H2BC9 SMARCA4 H2AZ2 H4C9 H2BC8 PPP3CB H2BC5 AP2S1 H2BC3 AP2A1 H2BC1 AP2B1 AP2A2 AP2M1 H2AC20 ARRB2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 80%388396 GPCR downstream signalling CCL19 CCL20 CAMK2B CAMK2D SRC CAMK2A CALM1 CAMK2G AVP TBXA2R FFAR3 GPR31 FFAR2 ROCK1 PLEKHG5 PIK3R6 HBEGF OPRD1 CXCR1 PLA2G4A CXCR2 MGLL AHCYL1 C5AR1 PRKCE PDE1C AKT3 CXCL8 CXCL1 PRKX CXCL2 CAMKK1 CAMKK2 OPRM1 VAV3 KPNA2 GRK2 PPP2R1A NBEA PRKACA TRPC7 TRPC6 TRPC3 ITSN1 PRKCD HEBP1 ANXA1 MT-RNR2 FPR1 FPR3 FPR2 PRKAR2B NGEF ARHGEF33 DGKG ARHGEF35 DGKE ARHGEF37 DGKD ARHGEF38 GNAT2 DGKB DGKA DGKZ DGKQ DGKK DGKI DGKH RPS6KA3 TAS2R7 RPS6KA2 TAS2R60 PRKCG RPS6KA1 TAS2R40 PRKCA TAS2R9 TAS2R41 TAS2R8 TAS2R20 TAS2R42 TAS2R43 TAS2R45 C3AR1 FGD1 TAS2R46 FGD2 GRM3 GPRC6A FGD3 FGD4 GRM2 PRKCB GRM5 GRM4 GRM7 GRM6 GRM8 TAS2R1 RGS17 TAS1R2 AKT2 RGS19 TAS1R1 RGSL1 TAS2R3 RGS16 TAS1R3 AKT1 RGS4 TAS2R5 TAS2R4 RGS20 PRKCH TAS2R50 CASR TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 TAS2R16 TAS2R39 TAS2R19 PTAFR OBSCN ITGB1 TRIO CAMK4 PREX1 PIK3R1 PLXNB1 EGFR NRAS PIK3CA RASGRF2 SOS1 HRAS VAV2 TIAM1 PLEKHG2 PIK3R2 SOS2 ROCK2 GABBR2 ABR GABBR1 MCF2 TIAM2 SST BTK PIK3R3 KALRN GRP NET1 FFAR4 FFAR1 AKAP13 MMP3 CXCL12 PPBP ITGA5 RHOC RHOB PPP2R5D ARHGEF9 PPP3CA ARHGEF3 MAPK7 PPP2R1B ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 KNG1 ARHGEF5 ARHGEF6 F2R F2 PENK SSTR3 PF4 ARHGEF40 AGTR1 MCHR1 RHO PPP3CB ARHGEF26 ARHGEF25 GNA12 ECT2 NPY ARHGEF39 TACR1 ARHGEF10L MCF2L PRKCQ ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 RASGRP2 ARHGEF19 RASGRP1 ARHGEF18 PPP1R1B PDE4B GNA13 PLCB3 PLCB4 PLCB1 PLCB2 PDPK1 GAST CCL4L2 RGS5 RGS2 RGS3 PRKACG RGS1 PRKACB RGS8 PCP2 GPSM1 CHRM2 GPSM2 ADCY9 CHRM3 GPSM3 CHRM1 RGS18 PRKAR1B CHRM4 RGS14 PRKAR1A CHRM5 RGS13 HTR2B RGS21 HTR2C RGS22 ADRB1 RGS10 ADRA1D RGS12 PRKAR2A ADRB2 HTR2A HTR4 ADRA1B ADRA1A TAAR3P CXCL6 HTR6 GNAS CXCL9 CXCL13 HRH1 HTR7 CXCL3 CXCL5 CX3CL1 HRH2 CXCL16 HRH4 PTGIR DRD1 CCR9 DRD3 CCR8 DRD4 CCR7 DRD5 CCR4 TAAR8 CCR3 ADCY4 HTR1E XCL2 TAAR9 XCL1 ADCY3 HTR1F CX3CR1 TAAR6 CCL13 ADCY2 ADCY1 HTR1D CXCR5 ADCY8 CXCR6 TAAR5 ADCY7 PDE1B ADCY6 HTR1B PDE1A CXCR3 TAAR2 ADCY5 ITPR1 CCL1 ITPR2 ADRA2C CCL16 ITPR3 HTR5A TAAR1 CCR10 CCL25 ADRA2B ADRA2A XCR1 PDE11A CCL21 GPR143 CXCL11 ADRB3 ACKR3 CCL28 CCL27 PDE2A PDE10A GNAL IAPP C3 APP NPFFR2 NPFFR1 RXFP4 RRH GRPR RXFP3 EDNRA EDNRB OXER1 PROK2 PROK1 OXTR UTS2R AVPR1B NPFF OXT C5 CDK5 GPR37L1 AVPR1A PDYN TRHR UTS2B AGTR2 PTGFR LPAR1 LPAR2 LPAR3 LPAR4 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 CYSLTR1 PPY HCRT NTSR1 NTSR2 GNAT1 GPR17 NMB NMBR SAA1 LPAR5 LPAR6 NMS GPR183 NMU PNOC GNRH2 GNRH1 GPR18 PTGDR2 QRFP MLN BRS3 GPR132 CCKAR OPN1LW GNRHR OXGR1 EDN1 GPR37 EDN2 EDN3 TACR2 TACR3 GAL OPN1MW CCKBR RGR NPB PTGER1 PTGER3 PROKR1 CXCL10 PROKR2 NPW KISS1R PPP2CA P2RY12 PPP2CB P2RY13 P2RY10 MAPK1 P2RY14 GPR55 MAPK3 GPR4 AGT CCL5 CCL4 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH NPY2R ADORA3 ADORA1 GHSR CXCR4 NPY1R MTNR1A LTB4R2 ABHD12 MTNR1B DAGLA APLNR UTS2 ABHD6 DAGLB SUCNR1 NTS MCHR2 HCAR2 HCAR3 HCAR1 TAC3 TAC1 OPN4 OPN3 CDC42 OPN5 PAK1 PYY NMUR2 NMUR1 MLNR TRH PIK3CG PIK3R5 LTB4R VAV1 BDKRB2 BDKRB1 CCR1 QRFPR INSL5 NPY5R GNRHR2 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 P2RY6 CNR2 P2RY4 CNR1 P2RY2 P2RY1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 RHOA CCK HCRTR2 HCRTR1 APLN KISS1 OPN1SW CCR6 CCR5 CCR2 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 PPP3CC PDE8B PDE8A PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL RGS9 GIPR RGS6 LHB RGS7 GPR83 GPR84 CRHR1 CRHR2 GHRHR PPP1CA GRK3 MC2R CALCR GRK5 GRK6 CGA PSAP GPR15 GNG10 MC1R PDE3A RLN2 RLN3 GPR27 GNG12 GNG11 GLP1R GPR25 GNG13 PDE3B GPR20 GNAQ ADM GNB2 PTH1R MC4R GNB1 GNB4 GPER1 PDE4A INSL3 GNB3 TSHB GPR39 GPR32 GNB5 FSHB PDE4D GLP2R AVPR2 GNGT1 PDE4C GPBAR1 PTH2R GNGT2 GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 GNA14 NPS GPR150 GPHA2 GNA15 P2RY11 GNG3 SCTR GCG CREB1 GNG2 GNG5 TSHR GNG4 POMC PPP3R1 GHRH GNA11 ADM2 GNG7 MC5R GNG8 PDE7B PDE7A VIP RAMP1 GPHB5 RGS11 ARRB1 ARRB2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 80%111885 Opioid Signalling PRKCG ADCY3 PRKCA ADCY2 ADCY1 ADCY8 PDE1C PDE1B ADCY7 PDE1A ADCY6 ITPR1 ADCY5 ITPR2 CAMK2B ITPR3 CAMK2D CAMK2A PPP3CC GNAT3 PRKX CAMKK1 CAMKK2 OPRM1 CALM1 CAMK2G PPP2CA PPP2CB PPP1CA KPNA2 GNAL MAPK1 GRK2 GNG10 PPP1R1B PPP2R1A PDE4B NBEA GNG12 PRKACA PPP2R5D GNG11 GNG13 PPP3CA GNAQ GNB2 PPP2R1B GNB1 GNB4 PDE4A GNB3 GNB5 PDE4D GNGT1 PDE4C GNGT2 PLCB3 PLCB4 PLCB1 PLCB2 CAMK4 GNAI3 GNAI1 GNAI2 GNA14 PRKCD GNA15 GNG3 CREB1 GNG2 GNG5 GNG4 POMC PPP3R1 GNA11 PRKAR2B GNG7 GNG8 CDK5 PRKACG PDYN PRKACB ADCY9 PRKAR1B PRKAR1A PPP3CB PLA2G4A PRKAR2A AHCYL1 ADCY4 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 80%5679090 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 GSD 0%REACTOME DATABASE ID RELEASE 80%3858516 GSD 0 GYG2 GYS2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.2 Nuclear Envelope Breakdown PRKCA CTDNEP1 NUP62 CNEP1R1 NUP214 NDC1 SEC13 NUP210 NUP133 EMD PRKCB LMNB1 NUP93 NUP50 NUP54 CCNB2 LEMD3 NUP205 CCNB1 POM121 LPIN1 AAAS LPIN2 NUP160 VRK1 LPIN3 LEMD2 NEK9 POM121C NEK6 NUP42 NEK7 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 PLK1 NUP155 CDK1 NUP153 NUP107 NUP188 NUP35 NUP37 BANF1 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 80%5610783 Degradation of GLI2 by the proteasome PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 CSNK1A1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PRKACA PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 CUL1 UBB UBC PRKACG PRKACB RPS27A GSK3B GLI2 SUFU RBX1 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.2 Galactose catabolism PGM2L1 GALE GALT PGM2 GALK1 S PHASE%REACTOME%R-HSA-69242.2 S Phase ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 CCND1 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 E2F1 PSMD1 SKP2 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 SMC1A PSMA3 PSMA4 TFDP1 PSMA1 CCNE2 PSMA2 AKT2 PSME3 TFDP2 PSME4 UBE2S PSME1 CDK4 AKT1 CCNE1 PSME2 CABLES1 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 WEE1 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 MYC PSMB10 PSMA8 RAD21 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 LIN54 PSMB9 SEM1 LIN52 PSMC5 PSMC6 PSMC3 RPA1 PSMC4 PSMC1 LIN37 PSMC2 PTK6 LIN9 STAG1 STAG2 FEN1 CKS1B MAX E2F5 CCNA2 CCNA1 DNA2 PRIM2 PRIM1 ESCO1 CDCA5 GMNN PDS5B ESCO2 ORC5 PDS5A ORC4 ORC6 WAPL ORC1 ORC3 ORC2 CDT1 CDC6 POLA1 POLA2 CDC25A GSK3B AKT3 PCNA POLD3 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 RPA2 POLE4 RPA3 POLE2 POLE3 SKP1 RBL2 CCNH E2F4 CDC25B UBA52 CUL1 UBB RBBP4 UBC CDK7 MNAT1 RPS27A GINS1 GINS2 CDC45 MCM7 MCM8 RB1 GINS3 GINS4 RBX1 CDKN1A MCM3 UBE2D1 ANAPC15 MCM4 CDKN1B MCM5 ANAPC16 MCM6 SMC3 ANAPC10 MCM2 MITOCHONDRIAL UNCOUPLING%REACTOME%R-HSA-166187.3 Mitochondrial Uncoupling UCP1 SLC25A14 PM20D1 SLC25A27 UCP3 UCP2 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 80%156587 Amino Acid conjugation ACSM5 ACSM4 GLYATL3 GLYATL2 GLYATL1 ACSM1 ACSM2A GLYAT ACSM2B FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 80%9614657 FOXO-mediated transcription of cell death genes CITED2 FOXO4 FOXO1 BCL6 CREBBP BCL2L11 STK11 BBC3 FASLG FOXO3 EP300 NFYA NFYB DDIT3 NFYC PINK1 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 80%5654733 Negative regulation of FGFR4 signaling UBA52 CBL KLB FRS2 FGF1 FGF2 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 BRAF PPP2CA PPP2CB MKNK1 RPS27A MAPK1 FGF19 SPRY2 MAPK3 FGFR4 PPP2R1A FGF16 FGF18 PTPN11 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 80%2029480 Fcgamma receptor (FCGR) dependent phagocytosis IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DOCK1 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MAPK1 IGKV3-15 IGKV3-11 MAPK3 LYN V2-8 IGHG3 V1-20 CFL1 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 FCGR1A IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 FCGR2A IGKV3-20 NCKAP1 IGHV4-34 CYFIP1 IGHV1-2 LIMK1 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 BRK1 IGLC2 V1-9 PLPP5 V5-4 PLPP4 V1-7 V5-1 CDC42 PLD4 V1-5 PAK1 ARPC4 ARPC5 V1-3 PLA2G6 IGKV3D-20 PLD1 V5-6 FYN PLD3 RAC1 PLD2 ARPC2 ARPC3 IGLV3-19 PIK3R1 VAV1 IGKV2-30 IGHV2-70 NF2 IGHV2-5 IGLV3-1 PIK3CA IGHV3-48 IGLV3-25 PLCG1 CRK IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 NCK1 IGHV3-53 ACTR3 VAV2 V4-2 IGLC7 ACTR2 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G YES1 PIK3R2 MYH9 NCKAP1L WASF3 WASF1 WASF2 MYO1C ELMO1 AHCYL1 FGR BAIAP2 PRKCE BTK PIK3CB ABI2 ITPR1 ABI1 ITPR2 ITPR3 HCK ACTB PTK2 PLCG2 VAV3 WASL SYK MYO5A MYH2 MYO10 HSP90AA1 WAS HSP90AB1 CYFIP2 WIPF1 WIPF2 WIPF3 MYO9B ABL1 PRKCD ACTG1 ELMO2 NCKIPSD ARPC1B ARPC1A IGHV3-23 IGLV IGLV2-8 IGKV1-16 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME%R-HSA-4793954.2 Defective MOGS causes CDG-2b MOGS G1 PHASE%REACTOME%R-HSA-69236.4 G1 Phase RBL2 RBL1 CCNH CKS1B CCND3 E2F4 CCND2 E2F5 CCND1 E2F1 E2F2 E2F3 SKP2 UBA52 CDKN2D CDKN2B CDK6 CDKN2C TFDP1 ABL1 CCNE2 TFDP2 CUL1 CDK4 CCNE1 CDK2 UBB UBC PPP2CA PPP2CB CDK7 RPS27A MNAT1 PPP2R2A LYN PPP2R1A CDKN2A PPP2R1B SKP1 PTK6 RB1 CDKN1C CDKN1A PPP2R3B CDKN1B JAK2 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.2 Defective ABCD1 causes ALD ABCD1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.3 Inhibition of membrane repair HGS DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 80%9605310 Defective Base Excision Repair Associated with MUTYH IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.3 IL-6-type cytokine receptor ligand interactions IL6ST IL31 JAK1 IL11RA OSM LIFR LIF TYK2 CRLF1 CNTFR IL31RA CTF1 IL11 CNTF OSMR CLCF1 JAK2 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.1 Vitamins B6 activation to pyridoxal phosphate PNPO AOX1 PDXK STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 80%9645135 STAT5 Activation STAT5A FLT3 STAT5B PTPN11 FLT3LG GAB2 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.3 Translation initiation complex formation RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA RPS3A EIF4E RPS4Y2 EIF4B RPS6 RPS27L RPS4Y1 RPS15A RPS3 RPS2 RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPS24 RPS23 RPS27A EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G RPS4X EIF3H RPS15 EIF3E EIF3F RPS14 EIF3C RPS17 PABPC1 EIF3D RPS16 EIF3A RPS19 EIF3B RPS18 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 80%72306 tRNA processing NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 CPSF4 NUP93 CPSF1 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP37 EPRS1 POP5 POP7 POP1 POP4 TSEN54 GTPBP3 TRMU TSEN2 TRMT112 MTO1 TRMT61B RTCB C2orf49 ZBTB8OS RTRAF XPOT TRNT1 DDX1 TSEN15 TSEN34 FAM98B RPP30 RPP38 RPP21 RPP25 RPP40 RPP14 RAN TRMT10C ELAC2 PRORP HSD17B10 CLP1 URM1 WDR4 THADA LAGE3 TP53RK OSGEP ALKBH8 THG1L CSTF2 TYW1 LCMT2 TRMT44 TRDMT1 PUS3 TRMT10A TYW5 METTL1 NSUN2 TYW3 TPRKB ADAT1 CDKAL1 TRMT1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 ADAT2 QTRT1 DUS2 TRMT9B CTU2 QTRT2 CTU1 TRMT5 TRMT6 TRMT12 TRMT13 TRMT11 TRMT61A NUP107 NUP188 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.3 Platelet degranulation ACTN4 TAGLN2 TLN1 TEX264 APOH VCL MANF MAGED2 ECM1 OLA1 CTSW TOR4A LY6G6F APOOL LHFPL2 POTEKP FAM3C ACTN2 TMX3 SELENOP TGFB2 CD9 TGFB3 RARRES2 FLNA CYRIB LGALS3BP AHSG PLEK SRGN MMRN1 CALM1 CLU CFL1 BRPF3 LAMP2 TGFB1 CD109 EGF IGF1 ALDOA THBS1 QSOX1 RAB27B PCDH7 LEFTY2 STXBP2 ACTN1 A2M PECAM1 CD63 PFN1 APOA1 HSPA5 ORM1 HGF ALB ORM2 CYB5R1 PDGFB TIMP1 PPBP PSAP CFD PLG PROS1 IGF2 F13A1 SERPINE1 KNG1 APP FGB FGA VWF APLP2 TUBA4A SCG3 FGG SPARC F5 SELP F8 TF CALU SERPING1 PF4 A1BG ISLR CHID1 SERPINF2 GTPBP2 SYTL4 NHLRC2 ENDOD1 VTI1B HRG FERMT3 GAS6 SERPINA4 TMSB4X TIMP3 CD36 ANXA5 SERPINA3 CAP1 SOD1 SPP2 PCYOX1L SERPINA1 ITGB3 ITGA2B VEGFB PPIA TTN VEGFC VEGFD SCCPDH VEGFA WDR1 PHACTR2 ITIH4 FN1 ITIH3 CLEC3B CDC37L1 HABP4 ABCC4 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME%R-HSA-3656244.2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ACAN LUM OGN OMD KERA PRELP FMOD B4GALT1 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 80%5579005 Defective CYP4F22 causes ARCI5 CYP4F22 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 80%5655332 Signaling by FGFR3 in disease FGF16 GAB1 FGF18 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FGF1 FGF2 FGF4 FGFR3 FGF9 FGF20 FGF23 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.2 Class B 2 (Secretin family receptors) VIPR1 VIPR2 SCT SHH CYSLTR2 IHH CD55 ADCYAP1 CALCA ADCYAP1R1 CALCB CALCRL GIPR WNT1 CRHR1 GHRHR CALCR IAPP GNG10 GNG12 GLP1R GNG11 GNG13 ADM GNB2 FZD10 PTH1R CRHBP GNB1 FZD9 GNB4 UCN3 FZD7 UCN2 GNB3 PTCH2 ADGRE1 ADGRE2 GNB5 GLP2R GNGT1 GNGT2 PTH2R WNT2B GIP WNT8A WNT8B CRH WNT6 RAMP2 WNT2 RAMP3 DHH WNT3 PTH WNT4 UCN WNT10A PTH2 PTHLH WNT3A WNT7B WNT9B WNT7A WNT9A WNT16 GNG3 SCTR GNG2 GCG GNG5 GNG4 GHRH GNG7 ADM2 GNG8 VIP RAMP1 SMO ADGRE5 ADGRE3 FZD1 PTCH1 FZD8 WNT10B WNT5A GNAS WNT11 FZD3 FZD2 FZD5 FZD4 FZD6 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.1 NIK-->noncanonical NF-kB signaling PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 FBXW11 RELB MAP3K14 UBA52 CUL1 UBB UBC RPS27A UBA3 UBE2M NFKB2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 80%140179 Amine Oxidase reactions PAOX MAOA MAOB NUCLEAR SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 80%1251985 Nuclear signaling by ERBB4 NCOR1 SPARC SRC CSN2 NRG1 STMN1 ESR1 ADAP1 MXD4 BTC NRG3 NRG4 NRG2 HBEGF EREG CXCL12 APH1A PSENEN APH1B PSEN2 GFAP ADAM17 S100B PGR WWOX TAB2 STAT5A YAP1 PSEN1 NCSTN APOE ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 80%9034864 Activated NTRK3 signals through RAS SOS1 NTRK3 HRAS NTF3 NRAS WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.1 WNT5A-dependent internalization of FZD4 DVL2 PRKCG PRKCA CLTC CLTA AP2S1 PRKCB AP2A1 AP2B1 AP2A2 AP2M1 WNT5A ARRB2 FZD4 CLTB CRISTAE FORMATION%REACTOME%R-HSA-8949613.2 Cristae formation CHCHD6 ATP5PO ATP5MG SAMM50 ATP5MF ATP5ME APOO MTX1 APOOL DNAJC11 IMMT TMEM11 CHCHD3 HSPA9 ATP5F1A ATP5F1B ATP5MC1 MTX2 DMAC2L ATP5PF ATP5PD ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATP5F1D ATP5F1E MICOS13 MT-ATP8 MICOS10 MT-ATP6 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.4 Activation of GABAB receptors ADCY3 GNGT2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAI3 GNAT3 GNAI1 GNAI2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAL ADCY9 KCNJ2 KCNJ3 GNG10 KCNJ4 GABBR2 KCNJ5 GABBR1 KCNJ10 KCNJ12 GNG12 KCNJ9 GNG11 GNG13 KCNJ15 GNB2 KCNJ16 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY4 MPS II - HUNTER SYNDROME%REACTOME DATABASE ID RELEASE 80%2206296 MPS II - Hunter syndrome IDS RHOH GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013407 RHOH GTPase cycle TUBA1B VANGL1 PAK1 LCK PAK6 PAK5 NSFL1C ARHGDIB PAK2 VCP DBT WDR11 TMEM59 ARHGDIG MTR ZAP70 RAB7A NIPSNAP2 VAMP3 ARHGDIA SLC1A5 ROCK2 RHOH UACA LAMTOR1 JUP RALGAPA1 STOM CSK FAM91A1 OSBPL11 PAK4 ROCK1 SLC4A7 TFRC DBN1 CAV1 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.2 Signaling by PTK6 CCND1 PELP1 DOK1 DOCK1 NRG1 PXN CDK4 AKT1 CCNE1 CDK2 ARAP1 RASA1 STAP2 PTPN1 SRMS PTK6 SFPQ KHDRBS1 KHDRBS2 NR3C1 KHDRBS3 BCAR1 ARHGAP35 RAC1 HIF1A EGF UBA52 CBL EGFR NRAS CRK SOCS3 HRAS EPAS1 BTC NRG3 NRG4 NRG2 HBEGF EREG UBB UBC RPS27A RHOA STAT3 ERBB2 ELMO2 GPNMB LRRK2 ELMO1 CDKN1B BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%R-HSA-1368108.4 BMAL1:CLOCK,NPAS2 activates circadian gene expression DBP NAMPT TBL1XR1 HELZ2 KLF15 TBL1X CLOCK ARNTL2 NPAS2 CREBBP ARNTL SMARCD3 NOCT CARM1 F7 BHLHE40 MED1 AVP NCOA2 CHD9 NCOA1 NCOA6 PPARA RXRA SERPINE1 BHLHE41 TGS1 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.1 PCNA-Dependent Long Patch Base Excision Repair POLE4 RPA3 POLE2 POLE3 PCNA POLD3 POLD4 POLD1 RPA1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 RFC2 POLB FEN1 RPA2 APEX1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 80%390918 Peroxisomal lipid metabolism SLC27A2 NUDT19 PHYH ACOT8 CROT AMACR HSD17B4 ACOX2 ACOXL ACAA1 ABCD1 NUDT7 HACL1 CRAT SLC25A17 EHHADH HAO2 PECR ACOT6 DECR2 ACOT4 ACBD4 ACOX3 ACBD5 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 80%9680187 Signaling by extracellular domain mutants of KIT KIT NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 80%8863678 Neurodegenerative Diseases YWHAE GOLGA2 CAPN2 CDK5R1 CDC25B CAPN1 PRDX2 CAST PRDX1 SOD2 BCL2L11 CDC25A LMNB1 CDC25C FASLG FOXO3 JUN CAPNS1 APP CDK5 CAPNS2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.1 VEGF ligand-receptor interactions FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA SYNTHESIS OF CL%REACTOME%R-HSA-1483076.2 Synthesis of CL CRLS1 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.3 Diseases of carbohydrate metabolism SI KHK SGSH LCT UBA52 NAGLU IDS GUSB EPM2A IDUA GBE1 GAA G6PC1 GYS2 UBB GYS1 G6PC3 HYAL1 PPP1R3C UBC NHLRC1 GYG2 SLC37A4 GNS RPS27A GYG1 ARSB HGSNAT GALNS ALDOB DCXR TALDO1 RPIA GLB1 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.2 HCMV Late Events UBAP1 CHMP4A CHMP6 CHMP7 NUP62 VPS25 NUP214 VPS28 NDC1 SEC13 NUP210 NUP133 H2AW H2AC17 H2AC12 H2AC1 H2BC18 H3C15 NUP93 H2AC21 NUP50 NUP54 NUP205 POM121 AAAS NUP160 CHMP1A POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP37 H2AC19 H2AC14 H2BC21 H2BU1 H2AC8 CEBPD H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 HNRNPK H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 TSG101 VPS4A H2AC20 MVB12B MVB12A VPS36 VPS37C VPS37D VPS37A SNF8 NUP107 VPS37B NUP188 H3C8 CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 PI-3K CASCADE:FGFR4%REACTOME%R-HSA-5654720.2 PI-3K cascade:FGFR4 FGF19 FGFR4 FGF16 GAB1 FGF18 PIK3R1 KLB PIK3CA FRS2 PTPN11 FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 80%211859 Biological oxidations GSTM1 TPMT AOC1 SLC35B3 GSTA1 SLC35B2 SLC35D1 PTGS1 GCLC GCLM GSTA3 MAOA MGST1 TRMT112 MTRR CYP11A1 FDX1 MTR FDX2 FDXR CYP11B2 CYP21A2 AHR ARNT2 AHRR CYP4V2 CYP4A22 CYP4A11 CYP3A43 CYP2A7 CYP2U1 CYP2A6 POR DPEP2 DPEP1 CYP3A5 DPEP3 CYP2C18 CYP3A7 CYP2B6 CYP2A13 CYP2F1 CYP4F22 CYP4F12 CYP2W1 CYP2S1 CYP2J2 CYP4F2 CYP4F3 CYP4B1 CYP4F8 CYP4F11 TBXAS1 CYP1A1 ADH4 ACSS2 ALDH1B1 ADH1C ADH1B ALDH1A1 ACSS1 ADH7 ACY1 ADH5 ADH6 SLC26A2 SLC26A1 HSP90AB1 GSS PTGIS CYP8B1 CYP51A1 CYB5R3 NR1H4 CYP7B1 GSTO1 AIP CYP7A1 CYP27A1 NAT1 NAT2 COMT UGT1A10 ACSM5 GSTA2 ACSM4 CYP2D6 GGT1 SULT2A1 UGT2B10 UGT2B11 UGT2B15 UGT2B17 CYP2E1 CES2 CES1 GSTT1 GLYAT CYP2C19 SULT1A1 UGT3A2 UGT3A1 SULT1A4 SULT1A3 GGT5 GLYATL3 GLYATL2 GGT7 GLYATL1 GGT6 CYP26C1 CYP2C9 CYP2C8 ACSM2A ACSM2B ALDH2 UGT1A3 UGT2A3 UGT2A2 UGT2A1 SULT1C4 UGT1A1 UGT2B4 UGT2B7 ADH1A UGT2B28 CYP19A1 CYP3A4 SULT1E1 UGT1A5 UGT1A9 UGT1A8 UGT1A7 UGT1A6 GSTP1 GGT3P CMBL ALDH3A1 MAOB N6AMT1 ACSM1 MTARC2 MTARC1 HPGDS AS3MT CYP1B1 EPHX1 ABHD10 BPHL CHAC2 CBR3 CHAC1 CYB5B GSTK1 AOC3 NQO2 MAT1A AOC2 TPST2 AADAC TPST1 SULT6B1 NNMT MGST3 MGST2 PAPSS1 GSTT2 RXRA ESD GSTT2B ARNT SULT1A2 GSTM4 GSTM3 GSTM2 GGCT SULT1B1 CYP1A2 GSTM5 PODXL2 OPLAH SULT1C2 SULT4A1 GSTO2 AKR1A1 ABHD14B UGDH AHCY MAT2B PAPSS2 UGP2 MAT2A BPNT2 BPNT1 GSTZ1 GSTA5 GSTA4 CES3 FMO1 FMO2 FMO3 ACY3 AKR7A2 AKR7A3 CYP11B1 PAOX NCOA2 PTGES3 CYP46A1 CYP39A1 AKR7L POMC UGT1A4 CYP27B1 NCOA1 CYP26A1 CYP26B1 CYP24A1 CYP2R1 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 80%2172127 DAP12 interactions BTK PIK3CB LCK FYN KLRC2 RAC1 SIGLEC16 PIK3R1 SIGLEC15 KLRD1 TYROBP SIGLEC14 NRAS CLEC5A PIK3CA PLCG1 KIR3DS1 SOS1 HRAS GRAP2 PLCG2 VAV2 VAV3 SYK LCP2 KLRK1 KIR2DS2 KIR2DS4 KIR2DS5 PIK3R2 TREM1 HLA-B HLA-C TREM2 CD300LB HLA-E CD300E NCR2 B2M SIRPB1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 80%9674519 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%75105 Fatty acyl-CoA biosynthesis TECR HACD1 HSD17B3 HACD3 HACD2 HACD4 HSD17B8 CBR4 OLAH PPT1 PPT2 ELOVL4 FASN ELOVL6 ELOVL7 ACSBG1 MORC2 ACSBG2 ACSF3 SLC27A3 ELOVL1 TECRL SLC25A1 ACSL1 ELOVL5 ELOVL2 ELOVL3 HSD17B12 ACSL4 ACSL3 ACACA ACSL6 ACSL5 SCD5 SCD HTD2 ACLY REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 80%5357905 Regulation of TNFR1 signaling IKBKB USP21 TNFAIP3 RBCK1 CASP8 IKBKG CHUK UBA52 XIAP TNF TRAF2 UBB SPPL2B UBC TAX1BP1 SPPL2A RPS27A USP4 USP2 CLIP3 OTULIN RIPK1 SHARPIN FADD TRADD CYLD OTUD7B RACK1 TRAF1 TNFRSF1A BIRC2 BIRC3 RNF31 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.2 Formation of annular gap junctions DAB2 DNM1 AP2M1 DNM2 CLTCL1 CLTC CLTA GJA1 CLTB L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.3 L13a-mediated translational silencing of Ceruloplasmin expression RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF4E RPS4Y2 EIF4B RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 EIF4A2 FAU EIF4A1 RPS21 RPL26L1 RPS24 RPS23 EIF1AX EIF4H EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 80%181431 Acetylcholine binding and downstream events CHRNG CHRNA4 CHRNE CHRNA6 CHRNA9 CHRNA7 CHRNB2 CHRNA1 CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 80%75953 RNA Polymerase II Transcription Initiation TAF9B TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2B GTF2E1 GTF2E2 ERCC3 ERCC2 TAF4B TAF7L GTF2A1 GTF2A2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 80%73728 RNA Polymerase I Promoter Opening H2AX H3-3B H2AB1 H2AC19 H2AC14 UBTF H2BC12L H2BC21 H2BU1 H2AC8 H3C15 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 MBD2 H2BC9 H2AZ2 MAPK3 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H3C8 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 80%416572 Sema4D induced cell migration and growth-cone collapse RHOA ERBB2 ROCK2 RHOC PLXNB1 RND1 RHOB MYL12B MYH9 ARHGEF11 LIMK2 MYH14 ARHGEF12 LIMK1 MYH11 ROCK1 MYH10 MYL6 SEMA4D MYL9 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 80%933541 TRAF6 mediated IRF7 activation IFNA6 IFNA2 IFNA8 IFIH1 TRAF6 TRIM4 CREBBP TRIM25 IKBKE IFNA13 IFNA14 IFNA16 EP300 DDX58 IFNA17 TRAF2 SIKE1 IRF3 IRF7 IFNA10 TANK RNF135 IFNA21 IFNB1 MAVS IFNA5 TBK1 IFNA4 IFNA7 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 80%3595177 Defective CHSY1 causes TPBS CSPG4 DCN NCAN BGN VCAN BCAN CHSY1 CSPG5 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 80%6814848 Glycerophospholipid catabolism GDE1 PNPLA7 ENPP6 GDPD1 GDPD3 PNPLA6 GDPD5 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 80%1638074 Keratan sulfate keratin metabolism ST3GAL6 SLC35D2 B4GAT1 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 GNS CHST6 B3GNT7 LUM B3GNT4 OGN B3GNT3 OMD CHST1 KERA B3GNT2 PRELP B4GALT6 FMOD CHST5 B4GALT4 B4GALT1 CHST2 B4GALT5 HEXB HEXA ACAN GLB1L GLB1 SIGNALING BY FGFR3%REACTOME%R-HSA-5654741.2 Signaling by FGFR3 GAB1 PIK3R1 UBA52 CBL NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 FGF1 FGF2 FGF4 UBB FGF9 FGF20 UBC FGF23 BRAF PPP2CA PPP2CB MKNK1 RPS27A GALNT3 MAPK1 SPRY2 MAPK3 PPP2R1A FGF16 FGF18 PTPN11 MPS VII - SLY SYNDROME%REACTOME%R-HSA-2206292.3 MPS VII - Sly syndrome GUSB RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.2 RPIA deficiency: failed conversion of R5P to RU5P RPIA SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.2 Signaling by TGF-beta Receptor Complex PARD3 PPP1R15A CGN USP15 LTBP4 NEDD4L NEDD8 LTBP2 LTBP3 LTBP1 ITGB8 PARP1 CCNT2 PMEPA1 CCNT1 ITGB6 TGFB2 TGFB3 TRIM33 UCHL5 TFDP1 SMAD7 BAMBI TFDP2 ITGA8 STRAP SNW1 ARHGEF18 USP9X XPO1 PPP1CA MYC MAPK1 FKBP1A ITGAV PPM1A PPP1CB MAPK3 PPP1CC MEN1 CDK9 F11R SMAD2 TGFB1 CDK8 TGFBR1 FURIN SMAD3 TGFBR2 ITGB1 SKIL SP1 SKI CCNC SERPINE1 STUB1 NCOR2 NCOR1 RBL1 UBE2D3 HDAC1 E2F4 E2F5 TGIF1 TGIF2 UBA52 CBL CDKN2B CCNK SMAD4 ITGB5 JUNB SMURF2 UBB SMURF1 WWTR1 UBC RPS27A RHOA PRKCZ UBE2M ATP1B4 PARD6A ITGB3 MTMR4 UBE2D1 RNF111 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.3 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 FURIN PROC F10 F9 PROS1 GAS6 PROZ BGLAP F2 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 80%6785470 tRNA processing in the mitochondrion TRMT10C ELAC2 PRORP TRNT1 HSD17B10 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 80%166658 Complement cascade IGKV1-17 IGKV1-12 IGHV3-7 CFH IGHV3-9 V2-11 CFI IGHV3-30 V3-4 V3-3 V2-17 C3AR1 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CPB2 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 VTN IGKV3-15 IGKV3-11 CLU V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 C4B_2 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 CR2 IGHV2-5 CR1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRP IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MBL2 C1S C1R CD46 C5AR2 ELANE C5AR1 C4A CPN2 CPN1 CD59 CD19 C1QB CD55 C1QA C1QC FCN1 FCN2 FCN3 CD81 MASP1 C3 CFD C8B GZMM CFB C8A C8G PROS1 COLEC11 COLEC10 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 F2 C4BPA C4BPB SERPING1 C2 C5 C6 C7 C9 IGHV3-23 IGLV IGLV2-8 IGKV1-16 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.2 Defective MMACHC causes MAHCC MMACHC RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9035034 RHOF GTPase cycle ARHGAP39 ARHGAP5 VANGL1 ARHGAP32 DIAPH3 SYDE1 DIAPH1 DIAPH2 BAIAP2L1 ESYT1 SOWAHC PIK3R1 MYO9B LMNB1 TMPO ACTB FARP1 STEAP3 DEPDC1B AKAP12 BASP1 SENP1 MTMR1 RAB7A VAMP3 PIK3R2 ADD3 FAM169A POTEE RHOF ARHGAP21 TOR1AIP1 ARHGAP12 CAPZB SRGAP2 SLC4A7 SNAP23 CAV1 MCAM ARHGAP1 BAIAP2L2 ACTN1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 80%2485179 Activation of the phototransduction cascade GNB1 RHO GNAT1 SAG PDE6B PDE6A PDE6G SLC24A1 CNGB1 GNGT1 CNGA1 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.3 KIT mutants bind TKIs KIT CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.1 Constitutive Signaling by NOTCH1 HD Domain Mutants RPS27A JAG2 ADAM10 NOTCH1 MIB2 UBA52 DLL1 MIB1 ADAM17 DLL4 NEURL1B NEURL1 JAG1 UBB UBC LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.1 Listeria monocytogenes entry into host cells RPS27A CTNNB1 EPS15 SH3GL2 STAM2 SH3GL3 MET UBA52 CBL HGS SRC SH3KBP1 STAM SH3GL1 CTNND1 CBLL1 UBB CDH1 UBC CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%R-HSA-2644606.1 Constitutive Signaling by NOTCH1 PEST Domain Mutants HEY1 HEY2 HES5 CREBBP HEYL NOTCH1 MAML2 HDAC10 MAML1 HDAC11 HDAC2 RBPJ HDAC8 KAT2B KAT2A SNW1 EP300 HDAC9 HES1 MAML3 MAMLD1 HDAC6 HDAC7 MYC HDAC4 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SKP1 HDAC5 CCNC NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X UBA52 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 ADAM17 PSEN1 RBX1 JAG1 NCSTN SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.2 Signaling by cytosolic FGFR1 fusion mutants ZMYM2 CUX1 FGFR1OP2 STAT3 MYO18A TRIM24 LRRFIP1 CPSF6 STAT1 GAB2 PIK3R1 PIK3CA CEP43 STAT5A STAT5B BCR HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 80%167161 HIV Transcription Initiation TAF9B TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2B GTF2E1 GTF2E2 ERCC3 ERCC2 TAF4B TAF7L GTF2A1 GTF2A2 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 80%5666185 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 RHOA TAX1BP3 ROPN1 RTKN RHPN2 LIN7B RHOC RHOB REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 80%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 UBA52 UBB UBC RPS27A FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 80%2033514 FGFR3 mutant receptor activation FGF1 FGF16 FGF2 FGF18 FGF4 FGFR3 FGF9 FGF20 FGF23 SULFIDE OXIDATION TO SULFATE%REACTOME%R-HSA-1614517.2 Sulfide oxidation to sulfate TSTD1 SQOR SUOX TST ETHE1 SLC25A10 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.3 Peroxisomal protein import DAO IDE HMGCL CROT NOS2 PAOX PEX1 PEX2 PEX7 LONP2 ACOX1 PEX6 ACOX3 AGXT USP9X PEX10 PEX12 PEX14 DDO IDH1 GSTK1 PIPOX DHRS4 NUDT7 GNPAT CRAT SLC27A2 UBE2D3 UBA52 AGPS EHHADH PECR ZFAND6 DECR2 ACOT4 UBB PEX26 UBC NUDT19 RPS27A MPV17 PHYH ACOT8 SCP2 BAAT ECH1 ACOT2 AMACR ACOX2 HSD17B4 ACAA1 CAT HACL1 HAO1 HAO2 UBE2D2 EPHX2 UBE2D1 TYSND1 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.2 Toxicity of botulinum toxin type D (botD) SV2C SV2B SV2A VAMP2 VAMP1 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.1 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain PLAGL1 NPM1 PLK3 CNOT10 CNOT4 CNOT6 RGCC PLK2 CNOT7 CNOT1 CNOT11 CDC25C CENPJ CNOT2 CNOT3 CNOT8 CNOT9 BTG2 TNKS1BP1 TP53 CNOT6L VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 80%4420097 VEGFA-VEGFR2 Pathway BAIAP2 CDH5 PRKCA TRIB3 PIK3CB MAPKAP1 ABI2 ITPR1 ABI1 ITPR2 ITPR3 AKT3 PRKCB DOCK1 SHC2 MAPKAPK3 MAPKAPK2 NOS3 AKT2 MLST8 PXN AKT1 RICTOR PTK2 MAPK14 VAV3 CALM1 MTOR ITGAV RASA1 CTNNB1 THEM4 PRR5 PRKACA PTK2B NCKAP1 HSP90AA1 CYFIP1 CTNND1 NCF1 ROCK1 NCF2 MAPK11 NCF4 BRK1 BCAR1 CYFIP2 CDC42 PAK1 PDPK1 CTNNA1 SPHK1 FYN RAC1 PAK3 PAK2 VAV1 PIK3R1 MAPK12 MAPK13 NRAS PIK3CA HSPB1 CRK PLCG1 CYBB HRAS PRKCD CYBA NCK2 NCK1 VAV2 PRKACG PRKACB RHOA PRKCZ PIK3R2 ELMO2 ROCK2 SHB SH2D2A JUP AXL ITGB3 KDR NCKAP1L WASF3 WASF1 WASF2 ELMO1 CAV1 AHCYL1 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 80%6784531 tRNA processing in the nucleus RPP40 NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 CPSF4 NUP93 CPSF1 RPP14 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAN RAE1 RANBP2 NUP155 NUP153 NUP35 NUP37 ELAC2 CLP1 POP5 POP7 POP1 POP4 CSTF2 TSEN54 TSEN2 RTCB C2orf49 ZBTB8OS RTRAF XPOT TRNT1 DDX1 TSEN15 TSEN34 FAM98B RPP30 RPP38 NUP107 NUP188 RPP21 RPP25 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.1 SARS-CoV-2 modulates host translation machinery RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA RPS3A RPS4Y2 RPS6 RPS27L RPS4Y1 RPS15A RPS3 RPS2 GEMIN2 SNRPD2 SNRPD1 SNRPD3 RPS26 RPS25 RPS28 RPS27 GEMIN4 RPS29 SNRPG GEMIN5 GEMIN6 RPS20 SNRPE FAU GEMIN7 RPS21 SNRPF GEMIN8 RPS24 SNRPB RPS23 DDX20 SMN2 RPS27A RPS4X RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 80%187577 SCF(Skp2)-mediated degradation of p27 p21 PSMD8 PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME1 CDK4 CCNE1 PSME2 PSMD10 CDK2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 CKS1B CCNA2 CCNA1 UBA52 CUL1 UBB UBC RPS27A CDKN1A CDKN1B PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.1 phospho-PLA2 pathway MAPK1 PLA2G4A POTASSIUM TRANSPORT CHANNELS%REACTOME DATABASE ID RELEASE 80%1296067 Potassium transport channels KCNJ16 KCNJ1 KCNJ10 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 80%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 80%209560 NF-kB is activated and signals survival IKBKB RELA NGFR RPS27A NGF IRAK1 TRAF6 SQSTM1 UBA52 NFKB1 NFKBIA UBB UBC NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 80%9717301 NVP-TAE684-resistant ALK mutants ALK NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 80%774815 Nucleosome assembly H2AX H2AB1 H2AC19 HJURP RSF1 H2AC14 H2BC12L MIS18BP1 H2BC21 RUVBL1 OIP5 H2BU1 H2AC8 H2AC6 H2AC7 KNL1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ITGB3BP CENPA CENPC RBBP4 RBBP7 H2AZ1 H2BC9 CENPT H2AZ2 CENPU NPM1 H4C9 H2BC8 CENPW CENPX H2BC5 H2BC3 SMARCA5 H2BC1 MIS18A CENPH CENPI H2AC20 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 80%8941856 RUNX3 regulates NOTCH signaling RUNX3 CREBBP NOTCH1 MAML2 MAML1 RBPJ KAT2B KAT2A SNW1 EP300 HES1 MAML3 MAMLD1 JAG1 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 80%8849175 Threonine catabolism RIDA SDSL GCAT SDS TDH GSD II%REACTOME DATABASE ID RELEASE 80%5357609 GSD II GYG1 GAA DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 80%5621480 Dectin-2 family MUC1 MUC2 MUC7 FYN MUC4 MUC6 MUC3A MUC3B PLCG2 MUC16 CLEC4A SYK MUC17 CLEC4C CLEC4D MUC19 CLEC4E MUC20 MUC21 LYN MUC5AC CLEC6A MUC5B MUC12 MUC15 FCER1G CLEC10A MUC13 MUCL1 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.2 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 80%110357 Displacement of DNA glycosylase by APEX1 NTHL1 MPG TDG MBD4 SMUG1 OGG1 APEX1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%977068 Termination of O-glycan biosynthesis MUC1 ST6GALNAC2 MUC2 MUC7 MUC4 MUC6 ST3GAL4 MUC3A ST3GAL1 MUC3B ST3GAL2 ST3GAL3 ST6GAL1 MUC16 MUC17 MUC19 MUC20 MUC21 ST6GALNAC3 MUC5AC ST6GALNAC4 MUC5B MUC12 MUC15 MUC13 MUCL1 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 80%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.2 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 80%110330 Recognition and association of DNA glycosylase with site containing an affected purine H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 MPG H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 OGG1 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 80%111997 CaM pathway ADCY3 PRKCG ADCY2 PRKCA ADCY1 ADCY8 CAMK4 PDE1C PDE1B ADCY7 PDE1A ADCY6 ADCY5 CAMK2B CAMK2D CAMK2A PRKX PRKCD CAMKK1 CAMKK2 CREB1 PRKAR2B CALM1 CAMK2G PRKACG PRKACB KPNA2 ADCY9 GRK2 PRKAR1B PRKAR1A NBEA PRKAR2A PRKACA ADCY4 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 80%449836 Other interleukin signaling CSF1R CSF1 JAK1 IL34 IFNL1 PTPRZ1 STX4 STX3 TYK2 CD4 CSF3R TXLNA SNAP25 STX1A CASP3 IFNLR1 VAMP2 PRTN3 IL32 IL10RB IL16 STXBP2 CSF3 SDC1 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.1 RHOT1 GTPase cycle TRAK1 TRAK2 RAP1GDS1 RHOT1 MYO19 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.2 Toxicity of botulinum toxin type G (botG) VAMP2 VAMP1 SYT1 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 80%418889 Ligand-independent caspase activation via DCC APPL1 CASP3 UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 MAGED1 DCC ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.1 Activated NTRK2 signals through FRS2 and FRS3 BDNF NTRK2 SOS1 HRAS FRS2 FRS3 PTPN11 NTF4 NRAS PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%196108 Pregnenolone biosynthesis FDX2 FDXR STARD6 TSPO STARD3NL TSPOAP1 AKR1B1 STARD3 STAR CYP11A1 STARD4 FDX1 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.3 Defective GALK1 causes GALCT2 GALK1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.4 Integrin cell surface interactions ICAM3 PECAM1 ICAM4 ICAM5 COL9A1 ICAM1 COL9A3 COL9A2 COL18A1 ITGB8 ITGB6 ITGA8 ITGAV VTN ITGA5 CD44 ITGA9 F11R ITGA7 ITGA6 ITGA2 ITGA10 ITGA1 ITGB1 SPP1 TNC JAM2 JAM3 FGB COMP FGA IBSP FGG COL4A2 COL4A1 ITGA11 COL4A4 ITGAE ITGAM ITGB5 COL4A3 ITGAD COL16A1 ITGB2 ITGAL FBN1 ITGAX VCAM1 ITGB7 CDH1 BSG THBS1 ITGA4 AGRN LUM COL23A1 HSPG2 ITGB3 ITGA2B KDR ITGA3 COL13A1 FN1 CD47 ICAM2 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.2 Classical antibody-mediated complement activation IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 C1QB IGHV7-81 C1QA V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 C1QC IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 CRP IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 C1S C1R IGHV3-23 IGLV IGLV2-8 IGKV1-16 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME%R-HSA-168276.5 NS1 Mediated Effects on Host Pathways NUP62 KPNA7 NUP214 KPNA4 NDC1 KPNA5 SEC13 NUP210 KPNA3 NUP133 CPSF4 NUP93 EIF2AK2 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C KPNA2 NUP42 NUP85 TPR NUP88 NUP43 RAE1 KPNB1 RANBP2 KPNA1 NUP155 PABPN1 ISG15 NUP153 NUP107 NUP188 NUP35 NUP37 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 80%187687 Signalling to ERKs CRKL SHC1 MAPK12 YWHAB MAPK13 SHC2 SHC3 NRAS MAPKAPK3 RALGDS MAPKAPK2 CRK SOS1 HRAS KIDINS220 FRS2 RALA MAPK14 RALB RIT1 RIT2 RAPGEF1 MAP2K1 BRAF MAPK1 NGF MAPK3 NTRK1 RAP1A MAP2K2 MAPK11 MRNA CAPPING%REACTOME%R-HSA-72086.3 mRNA Capping CCNH POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 NCBP1 GTF2H5 NCBP2 SUPT5H ERCC3 RNMT RNGTT ERCC2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.2 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR3GL TBP POLR1C POLR1D GTF3C1 GTF3C2 POLR2E POLR3A GTF3C3 POLR2F POLR3B GTF3C4 POLR3C GTF3C5 POLR2H POLR3D GTF3C6 POLR3E POLR2K POLR3F POLR2L POLR3G POLR3H POLR3K BRF1 BDP1 CRCP GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 80%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins FGB FGA TLN1 VWF FGG SRC ITGB3 ITGA2B SOS1 RAP1B PTK2 RAP1A FN1 APBB1IP DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 80%5260271 Diseases of Immune System IKBKB FGB FGA BTK HMGB1 IKBKG FGG CHUK S100A9 S100A8 TICAM1 TLR3 TRAF3 RELA UNC93B1 LY96 CD36 CD14 S100A1 MYD88 TIRAP NFKB1 TLR1 TLR10 NFKBIA TLR6 TLR5 TLR4 IRAK4 NFKB2 TLR2 CELL CYCLE%REACTOME%R-HSA-1640170.3 Cell Cycle HERC2 NUP62 NUP214 NDC1 PIAS4 SEC13 NUP210 NUP133 SMC1A NUP93 RNF168 FBXL7 NUP50 NUP54 NUP205 POM121 BLM AAAS NUP160 WRN POM121C NUP42 NUP85 RAD21 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 CSNK2A1 CDKN2A CSNK2A2 RPA1 NUP153 STAG1 CSNK2B STAG2 NUP35 NUP37 UBE2V2 TUBB8 TUBB8B TNPO1 AKT3 PCNA POLD3 POLD4 POLD1 FBXL18 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 LPIN1 RFC2 LPIN2 RPA2 LPIN3 CEP57 YWHAE POLE4 CETN2 RPA3 CEP164 POLE2 CCP110 POLE3 PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A BRCA2 YWHAG CDK5RAP2 SKP1 BRIP1 OFD1 KAT5 EXO1 HSP90AA1 CEP135 RBBP8 NBN PPP1R12A BARD1 BORA RMI2 FBXW11 RMI1 TUBB CEP131 HAUS4 TOP3A HAUS3 HAUS6 RAD50 CSNK1D HAUS5 RAD51 GOLGA2 CSNK1E TUBG1 ANKLE2 DYNLL1 CDC25B CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 UBA52 SFI1 AJUBA OPTN SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 HUS1 DYNC1LI1 CCNB1 DYNC1LI2 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC RHNO1 CEP72 CEP192 CDCA8 RPS27A PCNT CEP76 ATRIP CLASP1 CEP78 SKA1 PLK4 SKA2 DYNC1H1 ODF2 NDE1 TPX2 RAD17 CEP152 SFN PLK1 TUBB4B ATR TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 NUF2 GINS4 NUDC RBX1 MCM3 MCM4 MCM5 DYNLL2 MCM6 JAK2 MCM2 PSMD8 INCENP PSMD9 PRKCA PSMD6 MLH1 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 RAD1 PRKCB YWHAB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 AKT2 PSME3 KMT5A PSME4 PSME1 AKT1 PSME2 PSMD10 CENPF PSMB11 TAOK1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 CDC25C SEM1 PSMC5 RAD9B PSMC6 RAD9A PSMC3 CLIP1 PSMC4 PSMC1 PSMC2 MAD1L1 IST1 TOPBP1 HDAC1 NDC80 EMD LBR GMNN ORC5 SPDL1 SET LEMD3 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 RANGAP1 BIRC5 NSL1 ZW10 DSN1 RCC2 ZWINT AHCTF1 VRK1 LEMD2 SIRT2 XPO1 SYCP2 NDEL1 SYCP1 SYNE2 SYNE1 SUN2 SUN1 TEX12 SMC1B HSPA2 SYCE3 PPP2R5D SYCE2 SYCE1 REC8 STAG3 SPO11 TEX15 SYCP3 PPP2R1B MSH4 MSH5 DMC1 PSMC3IP MND1 MLH3 MIS12 H2AX H2AB1 H2AC19 HJURP DYNC1I1 RSF1 H2AC14 H2BC12L MIS18BP1 H2BC21 RUVBL1 OIP5 H2BU1 H2AC8 B9D2 H2AC6 GORASP2 BLZF1 H2AC7 KNL1 SPC24 SPC25 H2BC17 ERCC6L H2BC12 H2BC13 H2BC14 H2AJ ZWILCH H2BC15 H2BC11 ITGB3BP CENPA CENPC RBBP4 RBBP7 H2AZ1 KNTC1 H2BC9 CENPT H2AZ2 CENPU NPM1 SGO1 H4C9 H2BC8 SGO2 CENPW CENPX H2BC5 H2BC3 SMARCA5 H2BC1 MIS18A CENPH PMF1 CENPI H2AC20 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS UBE2D1 CTDNEP1 CNEP1R1 USO1 LMNB1 YWHAQ YWHAH YWHAZ MRE11 PPP2R2A PPME1 PHLDA1 GTSE1 LYN FKBPL TUBGCP2 HMMR PKMYT1 TUBGCP5 TUBGCP6 AURKB TUBGCP3 TUBGCP4 LIN54 FOXM1 UBE2N MYBL2 LIN52 BUB1 TUBG2 CLASP2 MZT2B RPS27 MZT2A NME7 LIN37 LIN9 LCMT1 CDK11A PPP2R3B CDK11B MZT1 RAB1A FEN1 DSCC1 RAB1B CHTF18 PPP6C RUVBL2 CKS1B MAX PPP6R3 E2F5 H3-3B FBXO5 TINF2 TERF1 DYRK1A PTTG1 CDC7 TERF2 DHFR CCNA2 TOP2A CCNA1 MCM10 SHQ1 TK1 DKC1 NHP2 DBF4 NCAPH2 POT1 TYMS NCAPG2 E2F6 TERF2IP CDKN2D DNA2 MCPH1 PIF1 CDKN2B NCAPD3 PRIM2 PRDM9 RRM2 CDKN2C RTEL1 PRIM1 RPA4 ESCO1 CHTF8 CDCA5 TERT POLR2A PDS5B POLR2B ESCO2 POLR2C PDS5A POLR2D WAPL GAR1 NSD2 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CTC1 ANKRD28 STN1 ACD POLA1 POLA2 TEN1 H3-4 NOP10 PPP2R5E GSK3B PPP2R5B PPP2R5A PPP2R5C CDC14A BANF1 RAB2A NUMA1 EP300 TP53 EML4 NEK9 NEK6 NEK7 PPP2R2D ENSA RCC1 MASTL ARPP19 RAN KPNB1 UBE2I SUMO1 HSP90AB1 KIF20A CCNH GORASP1 ABL1 SPAST CC2D1B ESPL1 KIF18A NCAPG NCAPD2 CDK7 SMC4 MNAT1 NCAPH SMC2 VPS4A RB1 CDKN1C CDKN1A H3C8 CHMP2B ANAPC15 CHMP4C CDKN1B CHMP2A ANAPC16 KIF23 CHMP4B ANAPC10 CHMP3 ANAPC11 FZR1 CHMP4A CCND3 CHMP6 CDC23 CHMP7 CCND2 RAD51C CCND1 CDC26 CDC27 KIF2A E2F1 E2F2 E2F3 SKP2 KIF2C DAXX KIF2B ANAPC7 UBE2C ATRX UBE2E1 H3C15 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CABLES1 CCNE1 CDC16 CENPE CDK2 ANAPC4 WEE1 ANAPC5 ANAPC1 ANAPC2 PPP2CA PPP2CB MYC MAPK1 PHF20 CHEK2 ZNF385A COP1 PCBP4 MDM2 MDM4 ATM PTK6 BABAM1 BABAM2 UIMC1 ABRAXAS1 RNF8 BRCC3 TP53BP1 BUB1B CDC20 BUB3 MAD2L1 CHEK1 CDC25A TUBB6 TUBB3 TUBB1 CLSPN TUBA4B FKBP6 TUBA8 WRAP53 TUBA1C TUBA1B RBL2 RBL1 E2F4 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C NIPBL MDC1 MAU2 NUP107 NUP188 BRCA1 SMC3 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 80%3828062 GSD 0 (muscle) GYG1 GYS1 SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 80%8853333 Signaling by FGFR2 fusions FGFR2 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.1 Phenylalanine metabolism ASRGL1 KYAT1 QDPR IL4I1 PAH PCBD1 DOWNSTREAM TCR SIGNALING%REACTOME DATABASE ID RELEASE 80%202424 Downstream TCR signaling IKBKB HLA-DPB1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 HLA-DQA2 PSMD1 HLA-DQA1 IKBKG MAP3K7 CHUK PSMA5 CDC34 HLA-DRB5 PSMA6 HLA-DRB4 PSMA3 PSMA4 PSMA1 PRKCQ PSMA2 PSME3 UBE2V1 RIPK2 PSME4 HLA-DQB2 PSME1 HLA-DQB1 PSME2 CARD11 TRBV12-3 PSMD10 HLA-DRB3 TRBV7-9 HLA-DRB1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 HLA-DRA BCL10 PSMA7 RELA MALT1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TRAV8-4 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 UBE2N PSMC5 TAB2 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PDPK1 LCK TRAF6 INPP5D PIK3R1 PIK3CA CD3G CD3E CD3D PIK3R2 TRAV29DV5 PIK3CB TRAT1 TRAC CD4 BTRC PTEN SKP1 FBXW11 UBA52 TRBC1 CUL1 TRAV19 UBB UBC RPS27A HLA-DPA1 UBE2D2 UBE2D1 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 80%175474 Assembly Of The HIV Virion UBAP1 RPS27A VPS28 UBA52 TSG101 MVB12B FURIN MVB12A PPIA VPS37C VPS37D NMT2 VPS37A VPS37B UBB UBC GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 80%70326 Glucose metabolism NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 GPI PFKFB2 NUP93 PFKFB1 PFKFB4 PFKFB3 NUP50 NUP54 PGP NUP205 POM121 ADPGK SLC25A12 AAAS BPGM NUP160 SLC25A13 PPP2CA PPP2CB POM121C NUP42 NUP85 GAPDHS PGK1 ENO1 TPR NUP88 PPP2R1A NUP43 RAE1 RANBP2 GOT1 PC HK2 PRKACA PPP2R5D HK3 NUP155 ENO2 ENO3 PPP2R1B PGK2 ALDOB PCK2 GOT2 SLC37A1 NUP153 PFKL TPI1 MDH1 PGAM2 HK1 G6PC2 GAPDH SLC25A11 NUP35 FBP1 NUP37 FBP2 SLC25A10 GCKR PCK1 G6PC1 G6PC3 ALDOC PRKACG SLC37A4 PRKACB ALDOA SLC25A1 PFKM PFKP MDH2 PGAM1 PGM2L1 NUP107 NUP188 GNPDA1 GNPDA2 GCK DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 80%2559586 DNA Damage Telomere Stress Induced Senescence ASF1A EP400 HMGA2 H1-1 CABIN1 H1-0 H1-3 H1-2 HIRA H1-5 UBN1 H1-4 LMNB1 CCNE2 CCNE1 CDK2 TP53 MRE11 KAT5 ATM NBN RAD50 H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 CCNA2 H2AC14 CCNA1 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 RB1 CDKN1A CDKN1B HMGA1 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.3 FRS-mediated FGFR1 signaling FGF22 FGF10 NRAS SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 80%2022377 Metabolism of Angiotensinogen to Angiotensins CTSZ AGT ANPEP ATP6AP2 ACE2 CPA3 CPB2 AOPEP ENPEP CPB1 MME CTSG ACE CTSD CMA1 GZMH CES1 REN FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.5 Fatty acid metabolism TECR GGT5 HSD17B3 HSD17B8 CYP2C9 PRKAA2 CYP2C8 CBR4 OLAH LTA4H NDUFAB1 ACAA2 PRKAG2 MAPKAPK2 MCEE ACOT11 ACOT12 ACOT13 MORC2 PON3 ACBD7 PON1 ACBD6 LTC4S PRKAB2 ACBD4 ACSF3 ACSF2 DBI ALOX5 CPT2 THRSP PTGS1 PPARD HPGDS CYP1B1 ABCC1 GPX1 ALOX12 RXRA SCD5 GPX2 ACLY CYP1A2 SLC27A2 ACADL AWAT1 PECR MMAA MMUT PCTP NUDT19 PHYH ACOT2 PLA2G4A CPT1B HADHB HADHA HACL1 HAO2 SCD EPHX2 FAAH CYP4A22 CBR1 CYP4A11 FAAH2 PTGR1 PTGR2 CYP2U1 DPEP2 CROT DPEP1 DPEP3 PTGES HPGD PON2 ALOX12B CYP4F22 ALOXE3 CYP2J2 CYP4F2 CYP4F3 CYP4B1 CYP4F8 CYP4F11 SLC25A17 PTGES2 PRXL2B ALOX5AP TBXAS1 CYP1A1 ACOX3 ALOX15 THEM4 PTGES3 PCCA ACSL4 PCCB ACSL3 ACACA NUDT7 CRAT ACOT9 MECR ACOT7 SLC22A5 CPT1A ACOT1 HACD1 HACD3 GPX4 HACD2 ALOX15B HACD4 MCAT ACOXL PPT1 PPT2 ACOT7L FASN ELOVL4 ELOVL6 PTGIS ELOVL7 ACSBG1 CYP8B1 EHHADH ACSBG2 ACOT6 DECR2 ACOT4 ECHS1 ACADM HADH SLC27A3 THEM5 AKR1C3 FADS2 ELOVL1 ACOT8 TECRL SCP2 ACSL1 SLC25A1 PTGDS ELOVL5 ELOVL2 AMACR ELOVL3 ACOX2 HSD17B4 ACSM3 ACAA1 ACSM6 ABCD1 FADS1 ACADS HSD17B12 ACADVL SLC25A20 MID1IP1 ECI1 GGT1 ACAD11 ACAD10 ACSL6 ACSL5 PTGS2 HTD2 DECR1 ACBD5 CYP2C19 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.5 G2 M DNA damage checkpoint HERC2 PIAS4 RAD1 YWHAB YWHAQ RNF168 YWHAH RFC5 RFC3 RFC4 WEE1 BLM RFC2 TP53 YWHAZ RPA2 MRE11 YWHAE WRN RPA3 CHEK2 CDC25C UBE2N YWHAG RAD9B RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 BABAM1 TOPBP1 RMI2 BABAM2 RMI1 UIMC1 TOP3A ABRAXAS1 RNF8 BRCC3 RAD50 TP53BP1 H2AX UBE2V2 H2BC12L H2BC21 H2BU1 DNA2 H2BC17 H2BC12 H2BC13 H2BC14 HUS1 H2BC15 CCNB1 H2BC11 NSD2 RHNO1 H2BC9 ATRIP H4C9 H2BC8 H2BC5 H3-4 H2BC3 RAD17 SFN CHEK1 H2BC1 ATR CDK1 MDC1 BRCA1 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 80%9657688 Defective factor XII causes hereditary angioedema KLKB1 F12 F2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 80%167246 Tat-mediated elongation of the HIV-1 transcript CCNH ELOB ELOC TCEA1 SSRP1 CCNT1 POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 ELOA2 SUPT5H CDK9 ERCC3 ELL ERCC2 ELOA NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.1 Neurophilin interactions with VEGF and VEGFR FLT1 KDR NRP2 NRP1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.2 Removal of the Flap Intermediate RPA3 POLA1 POLA2 DNA2 PRIM2 PCNA POLD3 PRIM1 POLD4 POLD1 RPA1 POLD2 FEN1 RPA2 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 80%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 CALM1 PRKACA MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.4 Maturation of nucleoprotein PARP14 PARP8 GSK3A CSNK1A1 SRPK2 SRPK1 GSK3B UBE2I SUMO1 PARP10 PARP6 PARP4 PARP16 PRMT1 PARP9 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 80%4608870 Asymmetric localization of PCP proteins PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 FZD7 PSMC1 PSMC2 DVL2 SCRIB UBA52 VANGL2 PRICKLE1 SMURF2 UBB SMURF1 UBC RPS27A PARD6A FZD1 FZD8 WNT5A FZD3 FZD2 FZD5 FZD4 M PHASE%REACTOME DATABASE ID RELEASE 80%68886 M Phase CTDNEP1 CNEP1R1 NUP62 NUP214 NDC1 SEC13 NUP210 USO1 NUP133 LMNB1 SMC1A NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C PPP2R2A NUP42 NUP85 RAD21 TPR NUP88 TUBGCP2 NUP43 RAE1 RANBP2 TUBGCP5 TUBGCP6 AURKB TUBGCP3 TUBGCP4 NUP155 CSNK2A1 BUB1 CSNK2A2 TUBG2 CLASP2 RPS27 MZT2B MZT2A NME7 NUP153 STAG1 CSNK2B STAG2 NUP35 MZT1 NUP37 RAB1A RAB1B H3-3B FBXO5 PTTG1 NCAPH2 NCAPG2 MCPH1 NCAPD3 CDCA5 PDS5B PDS5A WAPL TUBB8 H3-4 TUBB8B TNPO1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C BANF1 RAB2A NUMA1 LPIN1 LPIN2 LPIN3 EML4 CEP57 NEK9 YWHAE CETN2 NEK6 NEK7 CEP164 CCP110 ACTR1A PPP2R2D PCM1 ENSA RCC1 TUBA1A MASTL PPP2R1A ARPP19 RAN CNTRL KPNB1 CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 UBE2I HSP90AA1 CEP135 SUMO1 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D KIF20A HAUS5 GOLGA2 CSNK1E GORASP1 TUBG1 ANKLE2 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 UBA52 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 SPAST CCNB2 DYNC1LI1 CC2D1B CCNB1 DYNC1LI2 ESPL1 HAUS8 UBB KIF18A HAUS7 PRKAR2B CEP70 UBC NCAPG CEP72 CEP192 NCAPD2 SMC4 CDCA8 RPS27A NCAPH PCNT SMC2 CEP76 CLASP1 CEP78 SKA1 PLK4 SKA2 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 VPS4A CDK1 CEP41 CEP43 RB1 NUF2 H3C8 NUDC CHMP2B ANAPC15 CHMP4C CHMP2A ANAPC16 KIF23 DYNLL2 CHMP4B ANAPC10 CHMP3 ANAPC11 PSMD8 INCENP CHMP4A PSMD9 PRKCA CHMP6 PSMD6 CDC23 CHMP7 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 KIF2A PSMD3 PSMD1 KIF2C KIF2B PRKCB ANAPC7 PSMA5 UBE2C PSMA6 PSMA3 UBE2E1 PSMA4 H3C15 PSMA1 PSMA2 PSME3 KMT5A PSME4 UBE2S PSME1 PSME2 CDC16 CENPE PSMD10 CENPF ANAPC4 PSMB11 TAOK1 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB PSMB10 MAPK1 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CLIP1 PSMC4 PSMC1 PSMC2 MAD1L1 IST1 NDC80 EMD LBR SPDL1 SET LEMD3 RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 ZW10 DSN1 RCC2 TUBB6 TUBB3 ZWINT TUBB1 AHCTF1 VRK1 LEMD2 SIRT2 XPO1 TUBA4B NDEL1 PPP2R5D PPP2R1B TUBA8 MIS12 TUBA1C TUBA1B H2AX H2AB1 H2AC19 TUBB2B DYNC1I1 TUBB2A H2AC14 H2BC12L H2BC21 H2BU1 TUBAL3 H2AC8 B9D2 H2AC6 GORASP2 BLZF1 TUBA3E H2AC7 KNL1 SPC24 SPC25 H2BC17 TUBA3D ERCC6L H2BC12 H2BC13 H2BC14 H2AJ TUBA3C ZWILCH H2BC15 H2BC11 ITGB3BP CENPA CENPC KNTC1 H2AZ1 H2BC9 CENPT H2AZ2 CENPU SGO1 H4C9 H2BC8 SGO2 H2BC5 H2BC3 H2BC1 CENPH PMF1 CENPI H2AC20 CENPK CENPL CENPM CENPN CENPO CENPP NIPBL CENPQ CENPS MAU2 NUP107 NUP188 UBE2D1 SMC3 BLOCH PATHWAY%REACTOME%R-HSA-6807047.1 Bloch pathway DHCR24 EBP DHCR7 SC5D HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.1 HDR through MMEJ (alt-NHEJ) RAD50 LIG3 BRCA2 PARP2 POLQ RBBP8 NBN RAD52 PARP1 FEN1 MRE11 XRCC1 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.1 Suppression of apoptosis TRIM27 MAPK1 CTSG MAPK3 GSK3A SFPQ RNF213 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.3 VEGFR2 mediated cell proliferation PRKCA RASA1 PDPK1 PRKCZ SPHK1 ITPR1 ITPR2 ITPR3 PRKCB NRAS PLCG1 KDR PRKCD HRAS AHCYL1 CALM1 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.2 CREB3 factors activate genes CREB3 MBTPS1 CREB3L4 CREB3L3 CREB3L1 CREB3L2 CREBRF DCSTAMP MBTPS2 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.2 Latent infection - Other responses of Mtb to phagocytosis LTF SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 80%9674404 Sorafenib-resistant PDGFR mutants PDGFRA RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9696273 RND1 GTPase cycle FAM83B ARHGAP5 PLXNA1 DSP ANKRD26 VANGL1 ARHGAP35 DST PLEKHG5 TXNL1 GRB7 STMN2 PTPN13 PIK3R1 CCDC88A RND1 VANGL2 EPSTI1 UBXN11 DLG5 CPD KIDINS220 PKP4 RBMX FRS2 FRS3 LEMD3 TMEM59 KIF14 DEPDC1B EPHA2 PIK3R2 ALDH3A2 RASAL2 FAM135A TFRC STIP1 MUC13 CAV1 RRAS2 FLOT2 WDR6 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 80%2564830 Cytosolic iron-sulfur cluster assembly CIAO2B ABCB7 CIAO3 CIAO1 NUBP1 NUBP2 ERCC2 CIAPIN1 RTEL1 BRIP1 NDOR1 POLD1 MMS19 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.2 Retinoid cycle disease events RBP4 NAPEPLD OPN1LW RDH5 RBP1 OPN1SW OPN1MW RDH12 LRAT STRA6 TTR ABCA4 RLBP1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 80%190872 Transport of connexons to the plasma membrane GJB2 GJA1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 80%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer NCOR1 RBL1 HDAC1 UBE2D3 E2F4 E2F5 NEDD4L TGIF1 TGIF2 PARP1 UBA52 CCNT2 CCNT1 CDKN2B TRIM33 CCNK SMAD4 SMAD7 TFDP1 TFDP2 SNW1 JUNB SMURF2 UBB WWTR1 USP9X UBC MYC RPS27A MAPK1 PPM1A MAPK3 MEN1 ATP1B4 CDK9 SMAD2 CDK8 SMAD3 SKIL SP1 SKI CCNC SERPINE1 UBE2D1 RNF111 NCOR2 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 80%5173214 O-glycosylation of TSR domain-containing proteins CFP ADAMTS4 ADAMTS5 ADAMTS1 SEMA5A ADAMTS8 SPON2 ADAMTS9 SEMA5B SPON1 THSD7B B3GLCT THBS2 ADAMTS12 POFUT2 THBS1 THSD1 THSD4 ADAMTS10 ADAMTSL1 ADAMTS15 ADAMTS2 ADAMTS14 ADAMTS3 ADAMTS13 ADAMTSL5 ADAMTSL4 ADAMTS19 ADAMTSL3 ADAMTSL2 ADAMTS17 THSD7A ADAMTS6 ADAMTS7 SBSPON SSPOP ADAMTS20 ADAMTS16 ADAMTS18 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 80%110362 POLB-Dependent Long Patch Base Excision Repair PARP2 LIG1 PARG PARP1 POLB FEN1 APEX1 ADPRS RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.3 RAS GTPase cycle mutants KRAS HRAS NRAS MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-HSA-2555396.2 Mitotic Metaphase and Anaphase NUP62 NDC1 SEC13 NUP133 LMNB1 SMC1A NUP93 NUP54 NUP205 POM121 NUP160 PPP2R2A NUP85 RAD21 NUP43 RANBP2 AURKB NUP155 BUB1 CLASP2 RPS27 STAG1 STAG2 NUP35 NUP37 FBXO5 PTTG1 CDCA5 PDS5B PDS5A WAPL TUBB8 TUBB8B TNPO1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C BANF1 RCC1 TUBA1A PPP2R1A RAN KPNB1 UBE2I SUMO1 ANKLE2 DYNLL1 CKAP5 TUBA4A MAPRE1 UBA52 PAFAH1B1 DYNC1I2 SPAST CCNB2 DYNC1LI1 CC2D1B CCNB1 DYNC1LI2 ESPL1 UBB KIF18A UBC CDCA8 RPS27A CLASP1 SKA1 SKA2 DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A VPS4A CDK1 NUF2 NUDC CHMP2B ANAPC15 CHMP4C CHMP2A ANAPC16 DYNLL2 CHMP4B ANAPC10 CHMP3 ANAPC11 PSMD8 INCENP CHMP4A PSMD9 CHMP6 PSMD6 CDC23 CHMP7 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 KIF2A PSMD3 PSMD1 KIF2C KIF2B ANAPC7 PSMA5 UBE2C PSMA6 PSMA3 UBE2E1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 CENPE PSMD10 CENPF ANAPC4 PSMB11 TAOK1 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB PSMB10 PSMA8 PSMB6 PSMB7 PPP1CC PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CLIP1 PSMC4 PSMC1 PSMC2 MAD1L1 IST1 NDC80 EMD LBR SPDL1 LEMD3 RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 ZW10 DSN1 RCC2 TUBB6 TUBB3 ZWINT TUBB1 AHCTF1 VRK1 LEMD2 SIRT2 XPO1 TUBA4B NDEL1 PPP2R5D PPP2R1B TUBA8 MIS12 TUBA1C TUBA1B TUBB2B DYNC1I1 TUBB2A TUBAL3 B9D2 TUBA3E KNL1 SPC24 SPC25 TUBA3D ERCC6L TUBA3C ZWILCH ITGB3BP CENPA CENPC KNTC1 CENPT CENPU SGO1 SGO2 CENPH PMF1 CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUP188 UBE2D1 SMC3 PYROPTOSIS%REACTOME%R-HSA-5620971.3 Pyroptosis ELANE TP63 CHMP4A CHMP6 CHMP7 HMGB1 IRF1 IRF2 GSDMD CASP5 BAK1 CASP3 GZMB IL18 IL1A IL1B TP53 BAX GSDME CYCS CASP4 CHMP2B CHMP4C CASP1 CHMP2A CHMP4B CHMP3 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME DATABASE ID RELEASE 80%8953750 Transcriptional Regulation by E2F6 BMI1 RAD51 MAX CDC7 E2F1 MGA RING1 E2F6 EZH2 YAF2 UXT RRM2 TFDP1 TFDP2 EHMT1 EPC1 CBX5 SUZ12 RYBP RBBP4 RNF2 RBBP7 L3MBTL2 CHEK1 PHC1 EED PCGF2 RBBP8 PHC3 EHMT2 APAF1 CBX3 PCGF6 BRCA1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.1 Platelet calcium homeostasis ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 P2RX7 P2RX6 P2RX5 CALM1 P2RX4 P2RX3 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 TRPC7 TRPC6 TRPC3 STIM1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 80%428542 Regulation of commissural axon pathfinding by SLIT and ROBO NTN1 ROBO2 NELL2 ROBO1 SLIT1 SRC SLIT3 DCC SLIT2 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.5 Signaling by Receptor Tyrosine Kinases INSR ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 SRC NRG1 GRIN2B DLG4 CALM1 BAX WWP1 CTNND1 ROCK1 RNF41 CUL5 SOCS1 BTC NRG3 NRG4 IGF1 NRG2 HBEGF EREG MATK TNS4 TNS3 NCBP1 NCBP2 GFAP LAMC3 LAMA4 ITGA3 ELMO1 ATF2 AHCYL1 PRKCE TRIB3 FLT3 MAPKAP1 ID1 AKT3 EGR1 RICTOR GRAP2 GABRB3 VAV3 GABRB2 NEDD4 GABRB1 FOS GABRG3 GABRG2 IRS2 GABRQ GABRA1 THEM4 PPP2R1A PRR5 PRKACA CHD4 NTRK1 NTRK2 PLAT HSP90AA1 THBS4 THBS3 PDGFD REST STUB1 PTPRS CYFIP2 HIF1A STAT1 UBA52 LRIG1 PRKCD FRS2 FRS3 RALA FGF1 FGF2 FGF3 FGF4 UBB FGF6 FGF9 FGF20 UBC FGF23 FGF22 FGF10 RPS27A PRKCZ JUP NTF4 BDNF STAT5A ALK STAT5B PTPN11 MEF2A SGK1 MEF2C RPS6KA3 JAK2 RPS6KA5 RPS6KA2 TPH1 RPS6KA1 PRKCA ATF1 MAP2K5 RAB4A PRKCB YWHAB PRDM1 AKT2 KIDINS220 MLST8 PXN AKT1 JAK3 PTPN18 PTPN12 MTOR PTPN2 ITGB1 NCKAP1 CYFIP1 NCF1 NCF2 STAT6 NCF4 BRK1 HDAC3 NCOR1 HDAC1 SIN3A CD274 SHC1 EGF GAB1 PIK3R1 CBL EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 CYBB HRAS CYBA NCK2 NCK1 VAV2 TIAM1 RAPGEF1 MDK PIK3C3 PIK3R2 ROCK2 SRF ADAM10 ADAM17 IL2RG CSK NCKAP1L WASF3 IGF1R WASF1 WASF2 PSEN1 USP8 NCSTN CAV1 MEF2D NAB1 BAIAP2 NAB2 COL9A1 COL9A3 CRKL COL9A2 ABI2 ABI1 LAMC2 GRB7 LAMC1 PIK3R4 PIK3R3 SH3GL3 ARC TRIB1 SHC2 SHC3 RRAD RALGDS EGR3 EGR4 FOSL1 ID2 STAM ID4 ID3 PTK2 DNAL4 LYL1 RALB ASCL1 RIT1 RIT2 CDK5R2 CXCL12 MMP9 ITGAV FGF16 FGF7 FGF18 DUSP4 DUSP3 PPP2R5D LAMA5 VRK3 DUSP6 DUSP7 LAMA3 PGR PLG MAPK7 FURIN PPP2R1B JUND SPP1 ARHGEF7 LAMB3 CMA1 LAMB1 PTPN3 FOSB CTNNA1 SPINT1 F3 SPARC HPN SPINT2 HGFAC NTRK3 NTF3 EGR2 VGF MUC20 NRP2 ELMO2 STAM2 LAMB2 TEC YAP1 EPS15L1 CDH5 SH3GL2 DIAPH1 ARF6 GGA3 LYN PTK2B TAB2 LAMA2 LAMA1 MAPK11 RAB4B PDPK1 COL4A2 MAPK12 COL4A1 MAPK13 COL6A2 CSN2 COL4A4 STMN1 ADAP1 CRK MXD4 COL6A1 COL4A3 POLR2A POLR2B POLR2C COL6A3 POLR2D COL4A5 POLR2E POLR2F COL6A6 POLR2G COL6A5 MAP2K1 POLR2H POLR2I PRKACG POLR2J PRKACB POLR2K POLR2L YES1 SHB SH2D2A AXL CILP IRS4 MST1R PTPRO MST1 PTN MYCN EPS15 ITPR1 ITPR2 TCF12 ITPR3 ITCH TLR9 KLB FGFRL1 TIAL1 PTBP1 NOS3 FGFBP3 FGFBP1 RBFOX2 FGFBP2 EP300 SH3GL1 GTF2F1 GTF2F2 MAPK14 HNRNPH1 ESRP2 ESRP1 ANOS1 GRB10 FLRT2 FLRT3 FLRT1 SPRED2 HNRNPA1 SPRED1 TIA1 GALNT3 HNRNPM PTPN6 FGF19 RASA1 HNRNPF FGFR4 RANBP10 WWOX EPN1 ADAM12 CDK5 DOCK3 DOCK7 S100B DOCK1 MAPKAPK3 HDAC2 MAPKAPK2 SH3KBP1 SH2B3 SH2B2 SOCS6 BRAF PPP2CA PPP2CB MYC MKNK1 MAPK1 SPRY2 PTPRZ1 CTNNB1 MAPK3 AAMP HGS PTPN1 KIT PTK6 RANBP9 CDC42 CDK5R1 CLTC PAK1 LCK CLTA FYN RAC1 PAK3 PAK2 PAG1 VAV1 HSPB1 THBS2 THBS1 PTPRJ NGF RHOA FES NELFB CHEK1 DNM1 DNM2 DNM3 PCSK6 PCSK5 APOE IRS1 PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG GAB2 MET PDGFB TGFA ESR1 EPGN ADCYAP1 ADCYAP1R1 NRP1 PDE3B ITGA2 IGF2 BCAR1 MEMO1 ADORA2A SPHK1 PTPRU FER GRAP JUNB ELK1 CREB1 PTPRK SPRY1 STAT3 ERBB2 APH1A ERBIN PSENEN APH1B AP2S1 PSEN2 ATP6V1H AP2A1 ATP6V1A TCIRG1 AP2B1 AP2A2 INS AP2M1 ITGB3 ATP6V0A2 FLT1 ATP6V0A4 FLT4 ATP6V1E1 KDR ATP6V0E2 ATP6V1G3 VEGFB ATP6V1E2 VEGFC RAP1B VEGFD ATP6V1D PGF RAP1A ATP6V1C1 ATP6V0A1 VEGFA ATP6V1F MAP2K2 ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.3 Ubiquitin-dependent degradation of Cyclin D PSMD8 PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 CDK4 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 UBB UBC RPS27A GSK3B BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.1 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD FERTILIZATION%REACTOME DATABASE ID RELEASE 80%1187000 Fertilization CATSPER1 KCNU1 CATSPER3 HVCN1 CATSPERB CATSPER2 CATSPER4 CATSPERD CATSPERG B4GALT1 CD9 ADAM2 ACR IZUMO3 OVGP1 IZUMO2 IZUMO1 ZP1 ZP3 ZP2 SPAM1 ZP4 ADAM21 ADAM30 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 80%162592 Integration of provirus XRCC6 PSIP1 XRCC5 PPIA LIG4 BANF1 KPNA1 XRCC4 HMGA1 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 80%9702518 STAT5 activation downstream of FLT3 ITD mutants PIM1 STAT5A FLT3 GRB2 STAT5B PTPN11 BCL2L1 CDKN1A NOX4 GAB2 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME%R-HSA-6791055.2 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.1 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation IRAK2 RPS27A TRAF6 LY96 CD14 MAP3K7 TICAM2 UBA52 TAB3 TLR4 TAB2 TICAM1 TAB1 UBB UBC ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.4 Ion transport by P-type ATPases FXYD1 ATP10D FXYD7 ATP10B FXYD6 ATP10A ATP9B CAMK2B ATP9A SRI ATP8A1 CAMK2D CAMK2A ATP4B ATP4A ATP2B4 ATP2B3 CUTC ATP2B2 ATP2B1 CALM1 CAMK2G ATP2C2 ATP7A ATP2C1 ATP13A1 ATP13A4 ATP13A5 ATP13A2 ATP8B4 ATP11B ATP11A PDZD11 ATP2A3 ATP2A2 ATP2A1 ATP1B3 ATP8A2 ATP1B2 ATP12A ATP1B1 ATP11C ATP1A4 SLN ATP1A3 ATP8B3 ATP1A2 ATP8B2 ATP1A1 ATP8B1 PLN FXYD4 ATP7B FXYD3 FXYD2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 80%1963642 PI3K events in ERBB2 signaling ERBB2 EGF GAB1 PIK3R1 EGFR NRG1 PIK3CA BTC NRG3 NRG4 NRG2 HBEGF EREG LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.3 Loss of Function of SMAD2 3 in Cancer SMAD2 SMAD4 TGFB1 SMAD3 TGFBR1 TGFBR2 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 80%5625970 RHO GTPases activate KTN1 KLC2 CDC42 RHOA KIF5B RHOG RAC1 KIF5A KLC1 KTN1 KLC4 KLC3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.1 Type I hemidesmosome assembly ITGA6 LAMA3 COL17A1 DST PLEC LAMC2 LAMB3 CD151 ITGB4 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 80%6806667 Metabolism of fat-soluble vitamins GPIHBP1 RBP4 LRP2 CLPS APOA2 RBP2 PNLIP APOC3 APOA1 APOA4 RBP1 APOC2 RETSAT LRP8 RDH11 SDC4 TTR LDLR SDC2 SDC3 APOM GPC1 GPC3 AKR1C1 SDC1 GPC2 GPC5 AKR1C3 TTPA GPC4 BCO2 AKR1C4 AGRN BCO1 GPC6 PLB1 LRP10 AKR1B10 LRP12 VKORC1L1 HSPG2 UBIAD1 LRAT VKORC1 LPL APOE LRP1 APOB REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.2 Regulation of pyruvate dehydrogenase (PDH) complex PDPR PDK4 PDK3 DLAT PDK2 PPARD PDK1 PDHX PDHA2 PDHA1 PDP1 PDP2 GSTZ1 DLD RXRA PDHB CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 80%1500931 Cell-Cell communication CDH6 ACTN4 CDH5 CDH3 PARD3 CDH24 CADM3 CADM1 CADM2 CDH10 VASP CDH11 CDH12 CDH13 ANG NECTIN4 CDH17 ACTN2 TYROBP NECTIN3 CDH18 NECTIN1 FLNA PXN CTNNB1 PTK2B ITGB1 CTNND1 CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 KIRREL3 CLDN10 KIRREL1 CLDN4 DST KIRREL2 CLDN3 MAGI2 CLDN15 CD2AP CLDN9 CLDN14 NPHS1 CLDN8 FYN CLDN7 CLDN12 CLDN19 PIK3R1 CLDN18 CLDN17 CLDN16 PARD6G PIK3CA NCK2 NCK1 CDH1 CASK NECTIN2 PIK3R2 PARD6B PARD6A COL17A1 SIRPA CDH15 CD47 ACTN1 PIK3CB LAMC2 FERMT2 SPTBN1 PTK2 CDH4 CDH2 WASL PVR PLEC PTPN6 SPTAN1 FBLIM1 TESK1 ITGB4 F11R ILK PARVA PARVB ITGA6 LAMA3 FLNC RSU1 LIMS2 SDK1 LIMS1 CLDN5 SDK2 SKAP2 LAMB3 ARHGEF6 SIRPB1 CTNNA1 CD151 SIRPG ACTN3 PRKCI IQGAP1 FYB1 PATJ JUP CRB3 PTPN11 PALS1 CDH9 CDH8 CDH7 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.2 Mitotic Spindle Checkpoint ANAPC11 INCENP CDC23 CDC26 CDC27 KIF2A SEC13 NUP133 KIF2C KIF2B ANAPC7 UBE2C UBE2E1 UBE2S CDC16 CENPE ANAPC4 CENPF ANAPC5 TAOK1 ANAPC1 ANAPC2 NUP160 PPP2CA PPP2CB NUP85 PPP1CC NUP43 RANBP2 AURKB BUB1 CLASP2 CLIP1 RPS27 MAD1L1 NUP37 NDC80 SPDL1 RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C ZW10 DSN1 RCC2 ZWINT AHCTF1 XPO1 NDEL1 PPP2R1A PPP2R5D PPP2R1B MIS12 DYNLL1 CKAP5 DYNC1I1 MAPRE1 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L ZWILCH DYNC1LI1 DYNC1LI2 ITGB3BP KIF18A CENPA CENPC KNTC1 CDCA8 CENPT CENPU SGO1 CLASP1 SGO2 SKA1 SKA2 DYNC1H1 NDE1 PLK1 PMF1 CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 NUDC UBE2D1 ANAPC15 ANAPC16 DYNLL2 ANAPC10 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 80%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 80%2871809 FCERI mediated Ca+2 mobilization IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 NFATC3 V2-15 NFATC2 IGKV1D-39 NFATC1 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 CALM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 LYN V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 VAV1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 PLCG1 IGLV3-27 SOS1 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 IGHV3-53 VAV2 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 TXK AHCYL1 BTK ITPR1 ITPR2 ITPR3 GRAP2 PLCG2 VAV3 SYK LCP2 PPP3CA PPP3R1 PPP3CB ITK TEC IGHV3-23 IGLV IGLV2-8 IGKV1-16 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 80%9709603 Impaired BRCA2 binding to PALB2 RAD50 WRN RAD51 RAD51B RAD51C DNA2 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 BLM RMI1 XRCC2 TOP3A BRCA1 PALB2 MRE11 RAD51D DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.2 Defective SLC35D1 causes SCHBCKD SLC35D1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.1 NTRK2 activates RAC1 BDNF NTRK2 RAC1 DOCK3 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 80%391908 Prostanoid ligand receptors PTGDR2 PTGDR PTGFR TBXA2R PTGER1 PTGER4 PTGIR PTGER3 PTGER2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 80%422356 Regulation of insulin secretion PRKCA ADCY8 ADCY6 ITPR1 ADCY5 ADRA2C ITPR2 ITPR3 ADRA2A CACNA1D CACNA1C SLC2A1 FFAR1 RAPGEF3 RAPGEF4 CACNB2 CACNB3 GNG10 KCNJ11 ABCC8 GNG12 GLP1R PRKACA GNG11 GNG13 ACSL4 ACSL3 GNAQ STXBP1 GNB2 AKAP5 GNB1 GNB4 GNB3 GNB5 GNGT1 KCNG2 GNGT2 PLCB3 MARCKS PLCB1 PLCB2 CACNA1A CACNA1E SNAP25 STX1A GNAI1 KCNC2 GNAI2 GNA14 CACNA2D2 GNA15 GNG3 SYT5 GNG2 GCG GNG5 GNG4 GNA11 PRKAR2B GNG7 GNG8 PRKACG PRKACB IQGAP1 CHRM3 PRKAR1B PRKAR1A SLC2A2 CD36 PRKAR2A INS KCNB1 VAMP2 GNAS KCNS3 RAP1A AHCYL1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 80%69416 Dimerization of procaspase-8 TNFSF10 TNFRSF10B FAS TNFRSF10A TRADD FASLG TRAF2 CASP8 RIPK1 FADD SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.3 Signaling by GSK3beta mutants PPP2CA PPP2CB AMER1 CTNNB1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.4 Inhibition of Host mRNA Processing and RNA Silencing CPSF4 PABPN1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 80%69481 G2 M Checkpoints PSMD8 HERC2 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PIAS4 PSMD3 PSMD1 RAD1 YWHAB PSMA5 PSMA6 YWHAQ PSMA3 PSMA4 PSMA1 RNF168 PSMA2 PSME3 YWHAH PSME4 PSME1 PSME2 PSMD10 CDK2 PSMB11 WEE1 PSMD12 BLM PSMD11 PSMD14 PSMD13 YWHAZ MRE11 PSMA7 WRN PSMB10 PSMA8 PSMB6 GTSE1 PSMB7 PSMB4 PSMB5 PSMB2 PKMYT1 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 CHEK2 CDC25C SEM1 UBE2N RAD9B PSMC5 RAD9A PSMC6 PSMC3 RPA1 PSMC4 ATM PSMC1 PSMC2 BABAM1 TOPBP1 BABAM2 UIMC1 ABRAXAS1 RNF8 BRCC3 TP53BP1 CDC7 UBE2V2 MCM10 DBF4 DNA2 ORC5 ORC4 ORC6 ORC1 NSD2 ORC3 ORC2 CDC6 H3-4 CHEK1 CDC25A RFC5 RFC3 CLSPN RFC4 TP53 RFC2 RPA2 YWHAE RPA3 YWHAG BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 TOP3A RAD50 H2AX H2BC12L UBA52 H2BC21 H2BU1 H2BC17 H2BC12 H2BC13 H2BC14 CCNB2 HUS1 CCNB1 H2BC15 H2BC11 UBB UBC RHNO1 H2BC9 RPS27A ATRIP H4C9 H2BC8 H2BC5 RAD17 H2BC3 SFN ATR H2BC1 CDK1 CDC45 MCM7 MCM8 MDC1 MCM3 MCM4 MCM5 BRCA1 MCM6 MCM2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-HSA-2160916.3 Hyaluronan uptake and degradation HYAL3 HEXB CHP1 LYVE1 HEXA GUSB SLC9A1 HMMR CD44 HYAL1 HYAL2 STAB2 SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 80%1181150 Signaling by NODAL MAPK1 LEFTY1 MAPK3 FOXH1 ACVR2B CFC1 ACVR2A GDF1 TDGF1 NODAL SMAD2 SMAD4 SMAD3 FURIN FOXO3 PCSK6 TDGF1P3 ACVR1B DAND5 ACVR1C LEFTY2 CER1 DRAP1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.1 Molybdenum cofactor biosynthesis MOCS2 MOCS3 MOCOS GPHN DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.2 Defective MAT1A causes MATD MAT1A METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.3 Metabolic disorders of biological oxidation enzymes TPMT OPLAH MAOA CYP2U1 CYP11B1 AHCY CYP26C1 SLC35D1 CYP4F22 UGT1A1 GSS CYP17A1 TBXAS1 CYP19A1 CYP11A1 FDX1 FMO3 FDX2 FDXR CYP7B1 CYP11B2 CYP21A2 UGT1A4 CYP27A1 GCLC ACY1 CYP1B1 CYP27B1 CYP26B1 GCLM CYP24A1 CYP2R1 MAT1A GGT1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.4 Oxidative Stress Induced Senescence BMI1 MAP3K5 TNIK KDM6B E2F1 E2F2 RING1 E2F3 MINK1 MAP2K6 MOV10 MAP4K4 EZH2 MAPKAPK3 MAPKAPK2 H3C15 CDK6 TFDP1 TFDP2 CDK4 MAP2K4 MAPK14 SUZ12 MAP2K7 JUN MAPKAPK5 TP53 FOS RNF2 MAPK9 MAPK8 MAPK10 MAPK1 MAPK3 AGO3 AGO4 CBX6 AGO1 CBX8 PHC2 PHC1 MAP2K3 CBX4 EED CDKN2A CBX2 MDM2 MDM4 PHC3 TNRC6C MAPK11 TNRC6A TNRC6B H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 UBA52 H2BU1 CDKN2D H2AC8 CDKN2B H2AC6 H2AC7 CDKN2C H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB RBBP4 UBC RBBP7 H2AZ1 H2BC9 RPS27A H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 IFNB1 H2AC20 H3C8 EICOSANOIDS%REACTOME DATABASE ID RELEASE 80%211979 Eicosanoids CYP4F22 CYP4F12 CYP4A22 CYP4F2 CYP4A11 CYP4F3 PTGIS CYP4B1 CYP4F8 CYP8B1 CYP4F11 TBXAS1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.3 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation SALL4 SOX2 STAT3 NANOG POU5F1 FGF2 SALL1 ZIC3 FOXD3 TDGF1 DPPA4 EPHA1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702590 gilteritinib-resistant FLT3 mutants FLT3 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 80%9675135 Diseases of DNA repair RAD51B MLH1 RAD51C RAD1 NTHL1 RFC5 RFC3 MSH2 RFC4 BLM RFC2 RPA2 MRE11 WRN RPA3 SEM1 BRCA2 NEIL3 RAD9B RAD51AP1 RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51D RAD50 RAD51 MSH6 DNA2 MSH3 HUS1 NEIL1 OGG1 RHNO1 ATRIP RAD17 ATR BRCA1 PMS2 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.3 FGFRL1 modulation of FGFR1 signaling SPRED1 FGF22 FGFRL1 FGF10 FGF2 FGF3 FGF18 FGF4 SPRED2 FGF23 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.3 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) AKR1C3 CBR1 PTGS1 PTGR2 PTGDS HPGDS PTGES3 PTGES HPGD PTGIS CYP8B1 PTGES2 PTGS2 PRXL2B TBXAS1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 80%202427 Phosphorylation of CD3 and TCR zeta chains HLA-DPB1 LCK HLA-DQA2 HLA-DQA1 PAG1 HLA-DRB5 HLA-DRB4 TRBC1 HLA-DQB2 HLA-DQB1 TRBV12-3 TRBV7-9 TRAV19 HLA-DRB3 HLA-DRB1 HLA-DRA PTPRC CD3G TRAC PTPRJ CD3E CD3D CD4 TRAV8-4 HLA-DPA1 PTPN22 CSK TRAV29DV5 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 80%77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB HADHA ACADL ECHS1 HADH DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.2 Defective C1GALT1C1 causes TNPS MUC1 MUC20 MUC2 MUC21 MUC7 MUC5AC C1GALT1C1 MUC4 C1GALT1 MUC6 MUC5B MUC3A MUC12 MUC3B MUC15 MUC16 MUC13 MUC17 MUCL1 MUC19 CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-421270.6 Cell-cell junction organization CDH6 CDH5 CDH3 PARD3 CDH24 CADM3 CADM1 CADM2 CDH10 CDH11 CDH12 CDH13 ANG NECTIN4 CDH17 NECTIN3 CDH18 NECTIN1 CDH4 CDH2 PVR CTNNB1 F11R SDK1 CLDN5 SDK2 CTNND1 CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 CLDN4 CLDN3 CLDN15 CTNNA1 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 PARD6G CDH1 PRKCI NECTIN2 PATJ PARD6B PARD6A JUP CRB3 CDH15 PALS1 CDH9 CDH8 CDH7 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 80%8963889 Assembly of active LPL and LIPC lipase complexes GPIHBP1 FGF21 MBTPS1 APOA4 APOA5 APOC2 ANGPTL8 ANGPTL3 ANGPTL4 MBTPS2 FURIN LPL PCSK6 PCSK5 LMF2 LMF1 LIPC CREB3L3 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME%R-HSA-4549356.2 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME DATABASE ID RELEASE 80%5693568 Resolution of D-loop Structures through Holliday Junction Intermediates RAD50 RAD51 RAD51B RAD51C DNA2 BLM MRE11 WRN MUS81 EME1 EME2 GEN1 SLX1B SPIDR SLX4 XRCC3 SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 80%112308 Presynaptic depolarization and calcium channel opening CACNA2D3 CACNB1 CACNB2 CACNB3 CACNA2D2 CACNB4 CACNG2 CACNG4 CACNA1B CACNA1A CACNA2D1 CACNA1E UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.2 Unfolded Protein Response (UPR) YIF1A HDGF TLN1 ATP6V0D1 MBTPS1 TPP1 SULT1A3 GSK3A HSPA5 SERP1 DNAJC3 CXCL8 MBTPS2 EIF2AK3 ADD1 CCL2 CALR DIS3 CEBPB DCP2 SSR1 PARN LMNA EXOSC7 NFYA HYOU1 ATF3 EXOSC6 NFYB ARFGAP1 DDIT3 EXOSC5 EXOSC4 NFYC ATF6 EXOSC9 ATF4 EXOSC8 EXOSC3 ASNS IGFBP1 EXOSC2 EXOSC1 PDIA6 GOSR2 HSP90B1 CEBPG CUL7 SHC1 SRPRA DCTN1 SRPRB SEC31A WFS1 GFPT1 SYVN1 CREB3L4 CREB3L1 CREB3L2 CREBRF HERPUD1 DCSTAMP CREB3 PREB KHSRP KDELR3 EIF2S2 EIF2S1 PLA2G4B EIF2S3 ACADVL FKBP14 MYDGF TATDN2 TSPYL2 DDX11 PDIA5 ERN1 WIPI1 CTDSP2 DNAJB11 CXXC1 PPP2R5B EXTL2 CREB3L3 EXTL1 DNAJB9 EXTL3 EDEM1 ZBTB17 KLHDC3 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 80%5083625 Defective GALNT3 causes HFTC GALNT3 MUC1 MUC20 MUC2 MUC21 MUC7 MUC5AC MUC4 MUC6 MUC5B MUC3A MUC12 MUC3B MUC15 MUC16 MUC13 MUC17 MUCL1 MUC19 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 80%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function RAD50 RAD51 RAD51B RAD51C DNA2 BLM MRE11 WRN SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.2 Presynaptic function of Kainate receptors PLCB3 GNGT2 PLCB1 PLCB2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNG3 GNB3 GNG2 GRIK3 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 80%379401 Clearance of dopamine SLC6A3 MAOA COMT TOMT SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.1 Sodium-coupled phosphate cotransporters SLC20A2 SLC20A1 SLC34A3 SLC34A2 SLC34A1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.3 activated TAK1 mediates p38 MAPK activation IRAK2 IRAK1 TRAF6 IKBKG MAP3K7 MAP2K6 MAPKAPK3 MAPKAPK2 MAP2K3 UBE2N TAB3 TAB2 RIPK2 TAB1 UBE2V1 MAPK14 NOD1 MAPK11 NOD2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 80%5423646 Aflatoxin activation and detoxification GGT5 GGT3P ACY3 AKR7A2 GGT7 MGST1 AKR7A3 GGT6 DPEP2 ACY1 CYP3A5 DPEP1 DPEP3 AKR7L CYP2A13 GGT1 MGST3 MGST2 CYP3A4 CYP1A2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.1 Loss of Function of TGFBR1 in Cancer SMAD2 TGFB1 FKBP1A SMAD3 TGFBR1 TGFBR2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.1 The activation of arylsulfatases ARSL ARSJ ARSA ARSK SUMF2 ARSH SUMF1 ARSI ARSF ARSG ARSD ARSB STS MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 80%8874081 MET activates PTK2 signaling LAMC2 LAMC1 HGF MET LAMA5 SRC LAMB2 LAMA3 LAMC3 ITGA2 LAMA4 ITGA3 ITGB1 LAMA2 LAMA1 PTK2 LAMB3 LAMB1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME DATABASE ID RELEASE 80%9673202 Defective F9 variant does not activate FX F8 F10 F9 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.2 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 CEBPB RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU ATF3 RPS21 RPL26L1 RPS24 RPS23 GCN1 ASNS EIF2AK4 IMPACT CEBPG EIF2S2 EIF2S1 EIF2S3 ATF2 TRIB3 DDIT3 ATF4 UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.2 Interleukin-1 signaling IKBKB PSMD8 IL1RN PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 IL1R1 PSMD2 IL1R2 PSMD3 PSMD1 SQSTM1 IKBKG MAP3K7 MAP2K6 CHUK PSMA5 PSMA6 TOLLIP PSMA3 PSMA4 PSMA1 PSMA2 PSME3 UBE2V1 RIPK2 PSME4 PSME1 PSME2 IRAK3 IL1A PSMD10 IL1B PSMB11 PSMD12 NOD1 PSMD11 NOD2 PSMD14 PSMD13 MAP3K3 PSMA7 RELA PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 UBE2N TAB3 PSMC5 TAB2 PSMC6 TAB1 PSMC3 PSMC4 PSMC1 PSMC2 NFKBIB TRAF6 MAP2K1 TNIP2 MAP3K8 IRAK2 MAP2K4 IRAK1 PELI3 PELI2 PELI1 MYD88 BTRC IRAK4 SKP1 FBXW11 APP HMGB1 UBA52 NKIRAS1 NKIRAS2 CUL1 UBB UBC RPS27A AGER S100A12 S100B NFKB2 SAA1 RBX1 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 80%5663213 RHO GTPases Activate WASPs and WAVEs BAIAP2 CYFIP2 CDC42 BTK WIPF1 ARPC4 WIPF2 ARPC5 ABI2 ABI1 WIPF3 RAC1 ARPC2 ARPC3 ACTB ABL1 PTK2 NCK1 ACTR3 ACTG1 ACTR2 WASL MAPK1 MAPK3 NCKIPSD NCKAP1L WASF3 WASF1 ARPC1B NCKAP1 ARPC1A WASF2 CYFIP1 WAS BRK1 ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.3 Acyl chain remodelling of PS OSBPL10 PLA2G4F PLA2G2F PLA2G12A PLA2G5 PLA2G2D PLA2G4D PLA2G2E PLA2G4E PLA2G4B PLA2G4A PLA2G2A PLAAT3 MBOAT1 OSBPL8 OSBPL5 LPCAT4 LPCAT3 PLA2G10 PLA2G1B PLA2R1 PLA1A AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.1 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.2 GRB2 events in EGFR signaling EPGN SOS1 HRAS BTC AREG EGF HBEGF EREG TGFA EGFR NRAS RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 80%73863 RNA Polymerase I Transcription Termination CCNH TTF1 UBTF CAVIN1 TBP POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 80%9662001 Defective factor VIII causes hemophilia A TPST2 TPST1 F8 VWF F10 F9 F2 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 80%445144 Signal transduction by L1 NCAM1 MAPK1 PAK1 ITGAV MAPK3 RAC1 ITGA5 ITGA9 EGFR NRP1 ITGB3 CSNK2A1 ITGA2B CSNK2A2 L1CAM ITGB1 VAV2 MAP2K2 CSNK2B MAP2K1 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 80%5659735 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein GMDS ST8SIA6 ST3GAL6 FCSK FPGT NANS ST6GAL2 FUOM GFUS ST8SIA1 ST8SIA3 ST6GALNAC5 ST6GALNAC6 GNE GNPNAT1 RENBP SLC35A1 SLC35C1 ALG10 NEU2 NEU3 GMPPB GMPPA NEU1 DOLPP1 MVD DPAGT1 ALG8 CTSA ALG9 ALG6 ALG14 ALG2 ALG13 ALG3 ALG12 ALG1 MPDU1 PMM1 RFT1 GLB1 DPM1 DPM2 NUDT14 DPM3 UAP1 ST6GALNAC2 AMDHD2 GFPT2 PGM3 NAGK ALG5 NUS1 DHDDS ST3GAL4 ST3GAL1 GFPT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA4 ST8SIA2 ST6GALNAC3 ALG10B ST6GALNAC4 ALG11 ST6GALNAC1 CMAS NPL NANP SRD5A3 MPI NEU4 SLC17A5 PMM2 ST8SIA5 DOLK ST3GAL5 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.1 Visual phototransduction RBP4 PRKCA CLPS RBP2 RBP3 OPN1LW RDH5 RBP1 RETSAT OPN1MW RDH12 GUCY2D PRKCQ RDH11 RDH10 HSD17B6 GUCY2F RDH16 HSD17B1 MYO7A ABCA4 CALM1 NAPEPLD PLB1 SDR9C7 CAMKMT RGS9BP LRP1 LRP2 PNLIP DHRS3 DHRS9 GUCA1B GRK1 GUCA1A GUCA1C GRK7 SDC4 TTR LDLR SDC2 SDC3 GPC1 GPC3 SDC1 GPC2 GPC5 GPC4 AGRN GPC6 LRP10 PPEF1 OPN1SW LRP12 HSPG2 STRA6 LPL CYP4V2 APOE RLBP1 APOB CNGA1 GPIHBP1 AWAT2 APOA2 APOC3 APOA1 APOA4 SAG APOC2 LRP8 NMT1 BCO2 BCO1 RCVRN METAP1 METAP2 GNB1 GNGT1 SLC24A1 APOM CNGB1 AKR1C1 AKR1C3 RHO AKR1C4 RPE65 AKR1B10 FNTA FNTB LRAT GNAT1 PDE6B NMT2 PDE6A RDH8 PDE6G PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 80%1989781 PPARA activates gene expression HELZ2 ANKRD1 SLC27A1 NRF1 RXRB GRHL1 CPT2 UGT1A9 AGT CHD9 ME1 RXRA ARNT NCOR2 HDAC3 NCOR1 TBL1XR1 GPS2 TBL1X TXNRD1 PPARGC1A GLIPR1 MED19 ABCA1 MED1 MED16 NR1H2 MED15 MED8 MED18 NR1H3 MED9 MED17 MED12 MED4 MED11 MED14 MED6 MED13 MED10 MED7 MED27 MED26 MED29 MED28 MED23 MED22 MED25 MED24 MED21 MED20 PPARA CDK19 THRAP3 AHR ARNT2 AHRR FAM120B TIAM2 APOA2 TRIB3 CYP4A11 APOA1 APOA5 CREBBP ANGPTL4 HMGCS2 PPARG MED30 MED31 EP300 CYP1A1 PPARGC1B ESRRA FABP1 NCOA2 CDK8 SP1 CCNC MTF1 NFYA NFYB NFYC RORA TGS1 RGL1 CPT1A ABCB4 PLIN2 CLOCK NPAS2 FDFT1 ARNTL SMARCD3 CARM1 NR1D1 G0S2 ACADM MED13L NR1H4 ACSL1 FHL2 CYP7A1 CD36 HMGCS1 NCOA1 TNFRSF21 FADS1 NCOA6 NCOA3 SREBF2 SULT2A1 PEX11A ALAS1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%5662702 Melanin biosynthesis TYR OCA2 TYRP1 SLC45A2 DCT TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 80%2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) PARD3 RPS27A FKBP1A CGN PRKCZ RHOA UBA52 PARD6A F11R TGFB1 TGFBR1 TGFBR2 SMURF1 UBB ARHGEF18 UBC THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.1 The NLRP1 inflammasome NLRP1 BCL2L1 BCL2 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.3 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde KPNA2 CAMK4 CAMKK1 CAMKK2 CAMK2B CREB1 CALM1 CAMK2G FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.2 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 FBXL18 FBXL7 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 CUL1 AURKA UBB UBC RPS27A RBX1 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 80%5693571 Nonhomologous End-Joining (NHEJ) HERC2 PRKDC PIAS4 NHEJ1 RNF168 TDP2 TDP1 DCLRE1C RIF1 MRE11 POLL POLM XRCC4 UBE2N KAT5 ATM NBN BARD1 BABAM1 BABAM2 UIMC1 ABRAXAS1 RNF8 BRCC3 RAD50 TP53BP1 H2AX UBE2V2 H2BC12L H2BC21 H2BU1 XRCC6 XRCC5 PAXIP1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 NSD2 H2BC9 H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 MDC1 LIG4 BRCA1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 80%264642 Acetylcholine Neurotransmitter Release Cycle RAB3A CHAT UNC13B SYT1 CPLX1 SNAP25 STX1A RIMS1 SLC5A7 PPFIA1 VAMP2 PPFIA4 TSPOAP1 PPFIA3 PPFIA2 SLC18A3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 80%418885 DCC mediated attractive signaling CDC42 RAC1 SRC DOCK1 DCC NTN1 ABLIM1 ABLIM2 ABLIM3 PTK2 TRIO NCK1 WASL RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.1 RHOT2 GTPase cycle TRAK1 TRAK2 MFN1 MFN2 RAP1GDS1 RHOT2 MYO19 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.3 Mitochondrial transcription termination MTERF1 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 80%8865999 MET activates PTPN11 PTPN11 HGF GAB1 MET ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.3 Activation of gene expression by SREBF (SREBP) TBL1XR1 HELZ2 TBL1X FDFT1 CREBBP SQLE SMARCD3 CARM1 GPAM FASN IDI1 ELOVL6 SC5D MED1 FDPS TM7SF2 CYP51A1 PMVK LSS MVK DHCR7 NCOA2 CHD9 GGPS1 HMGCS1 NCOA1 MVD NCOA6 ACACB SREBF2 PPARA ACACA SP1 RXRA NFYA SCD MTF1 NFYB NFYC TGS1 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 80%9018678 Biosynthesis of specialized proresolving mediators (SPMs) ALOX15 PTGR1 CYP2C9 CYP2C8 HPGD LTA4H CYP2D6 ALOX12 PTGS2 ALOX5AP CYP2E1 GSTM4 LTC4S EPHX2 CYP3A4 CYP1A1 ALOX5 CYP1A2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.4 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion GNGT2 ADCY8 ADCY6 ITPR1 ADCY5 ITPR2 ITPR3 KCNC2 GNG3 GNG2 GCG GNG5 GNG4 PRKAR2B GNG7 GNG8 PRKACG PRKACB RAPGEF3 IQGAP1 RAPGEF4 PRKAR1B GNG10 PRKAR1A PRKAR2A GNG12 GLP1R PRKACA GNG11 KCNB1 GNG13 GNB2 GNAS AKAP5 GNB1 GNB4 KCNS3 RAP1A GNB3 GNB5 GNGT1 KCNG2 MPS IV - MORQUIO SYNDROME B%REACTOME DATABASE ID RELEASE 80%2206308 MPS IV - Morquio syndrome B GLB1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.4 CDC6 association with the ORC:origin complex ORC5 ORC4 MCM8 ORC6 ORC1 ORC3 ORC2 CDC6 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-HSA-1971475.2 A tetrasaccharide linker sequence is required for GAG synthesis XYLT2 XYLT1 SDC4 NCAN B4GALT7 SDC2 SDC3 B3GAT3 BGN B3GAT2 B3GALT6 B3GAT1 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 GPC5 CSPG4 GPC4 DCN AGRN GPC6 HSPG2 BCAN REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 80%5633007 Regulation of TP53 Activity TAF9B BRD7 HIPK1 POU4F2 HIPK2 PRKAA1 TTC5 PRKAA2 CCNG1 MAP2K6 DAXX RAD1 PRKAG1 PRKAG2 HDAC2 PRDM1 PRKAG3 STK11 AKT2 KMT5A MLST8 SUPT16H AKT1 CDK2 PRKAB2 KAT6A BLM MAPKAPK5 MRE11 PPP2CA PRKAB1 SMYD2 PPP2CB WRN MTOR BRPF1 BRPF3 AURKB JMY PHF20 CHEK2 CSNK2A1 TAF4B ZNF385A RAD9B CDKN2A CSNK2A2 RAD9A MDM2 MDM4 DYRK2 RPA1 ATM PPP1R13B PML PPP1R13L TOPBP1 CSNK2B MAPK11 TAF9 HDAC1 TAF1L TP53INP1 CDK5R1 RFFL PDPK1 TAF15 TAF12 TAF13 CCNA2 CCNA1 TAF10 TAF11 SSRP1 TAF7 TAF6 DNA2 TAF5 TAF4 TAF3 TAF2 TAF1 CHEK1 RNF34 PPP2R5C PIP4K2A PIP4K2B PIP4K2C MAPKAP1 AKT3 EP300 RICTOR RFC5 MBD3 MAPK14 RFC3 USP7 RFC4 GATAD2B GATAD2A TP53 RFC2 RPA2 RPA3 PPP2R1A PRR5 CHD4 CHD3 PRMT5 PPP2R1B BRIP1 KAT5 EXO1 RBBP8 NBN MTA2 BARD1 RMI2 RMI1 TOP3A TP63 RAD50 TP73 PLK3 UBA52 TBP TP53RK EHMT1 NOC2L AURKA HUS1 UBB RBBP4 UBC CDK5 RBBP7 RHNO1 L3MBTL1 MEAF6 RPS27A NUAK1 USP2 TP53BP2 ATRIP BANP TPX2 RAD17 ATR SETD9 CDK1 TAF7L ING5 ING2 PIN1 PIP4P1 EHMT2 BRD1 SGK1 BRCA1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 80%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) CYP4A22 GGT5 CYP4A11 ALOX15 PTGR1 DPEP2 DPEP1 DPEP3 LTA4H CYP4F22 MAPKAPK2 ABCC1 CYP4F2 GGT1 CYP4F3 CYP4B1 CYP4F8 CYP4F11 ALOX5AP LTC4S ALOX5 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 80%8849470 PTK6 Regulates Cell Cycle CCND1 CDK4 CCNE1 PTK6 CDK2 CDKN1B DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 80%916853 Degradation of GABA ALDH5A1 ABAT METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 80%351202 Metabolism of polyamines PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 SAT1 PSMA1 PSMA2 PAOX PSME3 PSME4 PSME1 PSME2 AGMAT PSMD10 PSMB11 PSMD12 AMD1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SMS AZIN2 ODC1 OAZ1 OAZ2 SRM OAZ3 NQO1 AZIN1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 80%111471 Apoptotic factor-mediated response APIP MAPK1 MAPK3 CASP9 UACA GSDME GSDMD CYCS BAK1 CDKN2A CASP3 XIAP CASP7 DIABLO CARD8 APAF1 AVEN C1QBP BAX HDL ASSEMBLY%REACTOME%R-HSA-8963896.1 HDL assembly PRKACG PRKACB APOA1 ABCA1 ZDHHC8 PRKACA A2M ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 80%1300645 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR IZUMO3 IZUMO2 IZUMO1 CD9 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 80%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination NAB1 NAB2 MPZ TEAD1 MAG PMP22 LAMC1 POU3F1 UTRN POU3F2 HDAC2 MBP ADGRG6 PRX WWTR1 EGR2 CYP51A1 SOX10 SMARCA4 DAG1 ADGRV1 SREBF2 LAMA2 DRP2 YAP1 HMGCR SCD5 LAMB1 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 80%5419276 Mitochondrial translation termination MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS2 MRPS18A MRPS21 MRPL47 MRPL48 MRPS7 MRPL45 GFM2 MRPS6 MRPL46 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRRF OXA1L MRPL53 MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPS33 MRPL18 MRPL19 MRPS34 MRPS31 MTRF1L MRPL16 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME DATABASE ID RELEASE 80%727802 Transport of nucleotide sugars SLC35A2 SLC35A1 SLC35B3 SLC35A3 SLC35B2 SLC35C1 SLC35B4 SLC35D1 SLC35D2 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.2 PI-3K cascade:FGFR1 FGF22 FGF10 GAB1 PIK3R1 PIK3CA FRS2 PTPN11 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 80%6804760 Regulation of TP53 Activity through Methylation L3MBTL1 SMYD2 RPS27A TTC5 UBA52 JMY SETD9 CHEK2 PRMT5 MDM2 KMT5A EHMT1 MDM4 EP300 ATM EHMT2 UBB TP53 UBC NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.8 Neurotransmitter receptors and postsynaptic signal transmission RPS6KA2 NSF RPS6KA1 PRKCG PRKCA GRIP2 GRIP1 TSPAN7 PICK1 GRIA3 GRIA4 CAMK2B PRKAA1 GRIA1 PRKAA2 GRIA2 CAMK2D PRKCB ACTN2 PRKAG1 SRC PRKAG2 CAMK2A PRKAG3 NRG1 GRIN2C GRIN2B GRIN1 NRGN GRIN2D GRIN2A DLG1 DLG2 DLG3 LRRC7 PRKAB2 DLG4 NEFL CALM1 CAMK2G PRKAB1 EPB41L1 MAPK1 MAPK3 MDM2 AKAP5 CHRNB2 CHRNA1 LIN7B CHRND CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNG CHRNA4 PLCB3 CHRNE CHRNA6 PLCB1 PLCB2 CAMK4 PDPK1 RAC1 GIT1 NRAS RASGRF2 HRAS RASGRF1 PRKACG KIF17 PRKACB CASK LIN7A LIN7C PPM1E ADCY9 PPM1F GRIN3B KCNJ2 PRKAR1B KCNJ3 APBA1 PRKAR1A KCNJ4 CAMK1 CHRNA9 GABBR2 KCNJ5 GABBR1 KCNJ10 PRKAR2A KCNJ12 KCNJ9 KCNJ15 KCNJ16 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 PRKX CAMKK1 CAMKK2 GABRB3 GABRB2 GABRB1 GABRR3 GABRR2 GABRR1 KPNA2 GNAL NPTN GABRG3 GABRG2 GABRA2 GABRQ GABRA1 GNG10 GABRA6 GABRA5 GABRA4 NBEA GABRA3 GNG12 PRKACA GNG11 GNG13 ARHGEF9 GNB2 GNB1 GNB4 GNB3 GRIK5 GNB5 GRIK3 GRIK4 GRIK1 GRIK2 GNGT1 GNGT2 GLRA1 GLRA2 GLRA3 CHRNA7 GNAI3 GNAI1 GNAI2 CACNG8 HTR3E HTR3C GNG3 HTR3D CACNG2 HTR3A CREB1 GNG2 CACNG3 HTR3B GNG5 CACNG4 GNG4 PRKAR2B GNG7 GNG8 NCALD RPS6KA6 MYO6 AP2A1 GLRB RPS6KA3 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 80%5619037 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 80%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 TP53 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 GTSE1 PSMB7 FKBPL PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 HSP90AA1 PSMC1 PSMC2 HSP90AB1 MAPRE1 UBA52 CCNB2 CCNB1 UBB UBC RPS27A PLK1 CDK1 CDKN1A SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol AKR1D1 AKR1C3 NR1H4 AKR1C2 AKR1C4 CYP7B1 NCOA2 CYP7A1 CYP27A1 NCOA1 PTGIS CYP8B1 RXRA HSD3B7 AKR1C1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 80%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal INCENP ZW10 KIF2A SEC13 NUP133 KIF2C KIF2B DSN1 RCC2 ZWINT CENPE AHCTF1 CENPF TAOK1 NUP160 PPP2CA XPO1 PPP2CB NUP85 PPP1CC NDEL1 PPP2R1A NUP43 RANBP2 AURKB PPP2R5D BUB1 PPP2R1B CLASP2 CLIP1 RPS27 MAD1L1 NUP37 MIS12 DYNLL1 CKAP5 DYNC1I1 NDC80 MAPRE1 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L SPDL1 ZWILCH DYNC1LI1 DYNC1LI2 ITGB3BP CENPA KIF18A CENPC KNTC1 RANGAP1 CDCA8 CENPT BIRC5 CENPU SGO1 CLASP1 BUB1B CDC20 SGO2 SKA1 SKA2 BUB3 DYNC1H1 MAD2L1 NDE1 NSL1 PLK1 PMF1 CENPH CENPI CENPK PPP2R5E CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 PPP2R5B NUDC PPP2R5A PPP2R5C DYNLL2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 80%936440 Negative regulators of RIG-I MDA5 signaling UBE2D3 TNFAIP3 UBE2L6 HERC5 IFIH1 ITCH TRIM4 UBA52 TRIM25 IKBKE DDX58 ATG12 UBB RNF125 IRF3 TRAF3 UBC TAX1BP1 NLRX1 UBA7 RPS27A NLRC5 RNF135 RNF216 PCBP2 ATG5 ISG15 CYLD MAVS PIN1 UBE2K UBE2D2 TBK1 UBE2D1 OTUD5 PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%73843 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.1 RUNX3 regulates p14-ARF KRAS HDAC4 TGFB1 BRD2 CBFB CCND1 EP300 RUNX3 RUNX1 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 80%9025106 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 80%71737 Pyrophosphate hydrolysis PPA2 LHPP PPA1 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 80%400206 Regulation of lipid metabolism by PPARalpha HELZ2 ANKRD1 SLC27A1 NRF1 RXRB GRHL1 CPT2 UGT1A9 AGT CHD9 ME1 RXRA ARNT NCOR2 HDAC3 NCOR1 TBL1XR1 SIN3A GPS2 TBL1X TXNRD1 PPARGC1A GLIPR1 MED19 ABCA1 MED1 MED16 NR1H2 MED15 MED8 MED18 NR1H3 MED9 MED17 MED12 MED4 MED11 MED14 MED6 MED13 MED10 MED7 MED27 MED26 MED29 MED28 MED23 MED22 MED25 MED24 MED21 MED20 PPARA CDK19 THRAP3 AHR ARNT2 AHRR FAM120B TIAM2 APOA2 TRIB3 CYP4A11 APOA1 APOA5 CREBBP ANGPTL4 HMGCS2 PPARG MED30 MED31 EP300 CYP1A1 PPARGC1B ESRRA FABP1 NCOA2 CDK8 SP1 CCNC MTF1 NFYA NFYB NFYC RORA TGS1 RGL1 CPT1A ABCB4 PLIN2 CLOCK NPAS2 FDFT1 ARNTL SMARCD3 CARM1 NR1D1 G0S2 ACADM MED13L NR1H4 ACSL1 FHL2 CYP7A1 CD36 HMGCS1 NCOA1 TNFRSF21 FADS1 NCOA6 NCOA3 SREBF2 SULT2A1 PEX11A ALAS1 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 80%877312 Regulation of IFNG signaling PIAS1 JAK1 SOCS3 PTPN6 SOCS1 SUMO1 PTPN11 IFNGR1 IFNGR2 PTPN1 IFNG JAK2 CENTROSOME MATURATION%REACTOME%R-HSA-380287.2 Centrosome maturation CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A TUBGCP2 PPP2R1A CNTRL CEP250 TUBGCP5 NEK2 TUBGCP6 TUBGCP3 PRKACA TUBGCP4 NINL CEP290 YWHAG CDK5RAP2 TUBG2 MZT2B OFD1 MZT2A HSP90AA1 NME7 CEP135 CDK11A TUBB CEP131 CDK11B HAUS4 MZT1 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.3 Hereditary fructose intolerance ALDOB ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 80%6803544 Ion influx efflux at host-pathogen interface ATP7A PDZD11 ATOX1 SLC11A1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.1 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant JAG2 JAG1 ADAM10 NOTCH1 DLL1 ADAM17 DLL4 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 80%69017 CDK-mediated phosphorylation and removal of Cdc6 ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 CCNE2 PSMA2 PSME3 PSME4 UBE2S PSME1 CCNE1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 UBA52 UBB CDC6 UBC RPS27A UBE2D1 ANAPC15 ANAPC16 ANAPC10 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 80%9652282 Drug-mediated inhibition of ERBB2 signaling CDC37 HSP90AA1 ERBB2 ERBIN SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.1 Signaling by juxtamembrane domain KIT mutants KIT FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.2 Formation of tubulin folding intermediates by CCT TriC TUBA1B CCT3 CCT2 TUBA4A TUBB2B TUBB2A TCP1 TUBAL3 TUBA3E CCT6B TUBB6 TUBA3D TUBB3 TUBB1 TUBA3C CCT8 CCT7 CCT5 CCT4 TUBA4B TUBA1A TUBB4B TUBB4A CCT6A TUBA8 TUBA1C GENE SILENCING BY RNA%REACTOME DATABASE ID RELEASE 80%211000 Gene Silencing by RNA NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 ANG H3C15 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NUP155 NUP153 DDX4 NUP35 NUP37 H3-3B PLD6 BCDIN3D DROSHA IPO8 XPO5 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L DGCR8 TSNAX AGO3 PRKRA AGO4 PIWIL2 TDRKH AGO1 RAN AGO2 PIWIL1 DICER1 PIWIL4 HENMT1 TSN ASZ1 TARBP2 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 HSP90AA1 TNRC6C TNRC6A TNRC6B H2AX H2AB1 H2AC19 ELAC2 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NUP107 NUP188 H3C8 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways IKBKB HMOX1 CARD9 CASP9 IKBKG ITCH MAP3K7 MAP2K6 CHUK TXNIP PYCARD RIPK2 UBE2V1 MAPK14 NOD1 P2RX7 NOD2 PANX1 RELA IRAK1 NLRP3 NLRP1 AAMP NFKB1 CASP4 UBE2N TAB3 TAB2 TAB1 AIM2 MAPK11 CASP1 APP CASP2 NLRC4 HSP90AB1 TNFAIP3 TRAF6 BCL2L1 CASP8 PSTPIP1 MAPK12 MAPK13 BCL2 MEFV IRAK2 NFKB2 CYLD SUGT1 BIRC2 BIRC3 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 80%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%5619115 Disorders of transmembrane transporters PSMD8 SLC11A2 PSMD9 PSMD6 PSMD7 NUP62 PSMD4 NUP214 PSMD5 NDC1 PSMD2 SLC40A1 PSMD3 CP SEC13 PSMD1 NUP210 NUP133 SLCO1B1 PSMA5 PSMA6 PSMA3 SLCO1B3 PSMA4 NUP93 PSMA1 PSMA2 PSME3 SLC35A2 PSME4 SLC35A1 PSME1 NUP50 SLC35A3 PSME2 SLC33A1 NUP54 SLC35C1 PSMD10 NUP205 POM121 PSMB11 PSMD12 SLC2A9 SLCO2A1 PSMD11 PSMD14 AAAS PSMD13 NUP160 SLC2A1 PSMA7 POM121C AVP PSMB10 NUP42 SLC16A1 NUP85 PSMA8 PSMB6 PSMB7 TPR PSMB4 NUP88 SLC29A3 PSMB5 KCNJ11 ABCC8 PSMB2 NUP43 ABCC9 PSMB3 RAE1 PSMB1 RANBP2 SLC27A4 PSMF1 PSMB8 PSMB9 NUP155 SEM1 SLC2A10 PSMC5 SLC5A7 PSMC6 PSMC3 PSMC4 SLC5A1 NUP153 PSMC1 PSMC2 HK1 NUP35 NUP37 SLC36A2 VCP GCKR SEL1L DERL2 ERLEC1 OS9 ABCA1 ABCA12 BSG ABCB6 SLC2A2 SLC17A5 RNF5 RNF185 CFTR APOA1 SLC9A6 SLC5A2 RHAG SLC4A1 SLC9A9 SLC34A3 SLC34A2 SLC34A1 DERL1 DERL3 ERLIN1 SLC4A4 SLC6A19 SLC12A6 SLC6A18 SLC6A14 SLC26A2 ABCG8 ABCG5 SLC1A1 SLC6A20 ABCD4 SLC1A3 SLC6A2 SLC6A3 SLC6A5 SLC5A5 SLC22A18 ABCA3 LMBRD1 AVPR2 SLC26A4 SLC26A3 SLC22A5 SLC22A12 ABCB4 SLC7A9 SLC7A7 SLC3A1 ERLIN2 UBA52 SLC24A1 SLC24A4 SLC20A2 SLC3A2 UBB ABCC6 SLC17A8 AVPR1B UBC AVPR1A SLC12A3 RPS27A SLC12A1 ABCB11 SLC24A5 ABCD1 HEPH ABCC2 SLC39A4 NUP107 NUP188 GCK SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.2 Sensory perception of taste TAS2R40 TAS2R41 SCN9A TAS2R8 PLCB2 TAS2R20 TAS2R43 TAS2R46 ITPR3 GRM4 GNAT3 TAS2R1 TAS1R2 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 TAS2R30 SCN3A TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 OTOP1 TAS2R16 TAS2R39 SCN2A KCNJ2 SCN2B GNG13 SCN4B TRPM5 GNB1 TRPM4 SCNN1G CALHM1 GNB3 SCNN1D SCNN1B SCNN1A CALHM3 SCN1B TAS2R7 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.3 Viral RNP Complexes in the Host Cell Nucleus HSPA1A HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 80%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA4 CHRNA6 CHRNB2 CHRNA1 CHRNA9 CHRNB4 CHRNA3 CHRNA7 CHRNB3 CHRNA2 CHRNA5 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 80%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS GPC2 EXT1 GPC5 EXT2 GPC4 AGRN GPC6 HSPG2 SDC4 SDC2 SDC3 GPC1 GPC3 SDC1 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 80%549127 Organic cation transport RSC1A1 SLC22A5 SLC22A3 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A1 SLC22A4 RUNX1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 80%6790901 rRNA modification in the nucleus and cytosol EMG1 UTP20 NOP14 RCL1 RPS9 DDX49 DDX47 RPS7 WDR3 BUD23 UTP15 UTP11 DDX52 UTP18 BMS1 DCAF13 NOP58 KRR1 RPS6 NOP2 RPS2 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 DKC1 IMP4 NHP2 RRP7A PDCD11 DHX37 PNO1 TBL3 MPHOSPH10 NOL11 SNU13 NAT10 WDR46 WDR43 TRMT112 GAR1 UTP14A UTP14C WDR36 TSR3 NOP56 HEATR1 NOC4L NOL6 RRP36 UTP6 NOP10 UTP4 UTP3 RPS14 FBL DIMT1 UTP25 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.3 RAB GEFs exchange GTP for GDP on RABs ALS2CL RGP1 AKT3 RAB3GAP2 RAB13 RAB3GAP1 DENND5B CHML TRAPPC12 RIC1 TRAPPC11 TRAPPC10 AKT2 DENND5A TRAPPC13 AKT1 TRAPPC2L RAB32 DENND6B RAB35 DENND6A RAB38 RAB27A RAB3A RAB6B YWHAE ALS2 TRAPPC2 TRAPPC3 ANKRD27 TRAPPC4 HPS1 DENND4B TRAPPC5 DENND4A HPS4 DENND4C TRAPPC8 CCZ1 TRAPPC9 RAB8A RAB31 RAB5B RAB5C SBF1 RAB6A TRAPPC6A RAB1A RAB1B TRAPPC6B DENND3 RAB21 TRAPPC1 SBF2 RAB12 RAB9A RAB9B GDI2 RINL RABGEF1 RAB10 RAB7A RAB18 GAPVD1 ULK1 RAB5A RIN3 RIN1 RAB3IP RIN2 CCZ1B RAB39A RAB39B RAB27B CHM MON1A DENND1C MON1B DENND1B GDI1 DENND1A DENND2D RAB8B DENND2C DENND2B DENND2A RAB3IL1 RAB7B RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.4 Response to metal ions MT1E MT2A MT1M MT1X CSRP1 MT4 MTF1 MT3 SNCB MT1A MT1F MT1G MT1H MT1B SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 80%2142712 Synthesis of 12-eicosatetraenoic acid derivatives ALOXE3 GPX1 GPX4 ALOX15 ALOX12 GPX2 ALOX12B SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 80%373755 Semaphorin interactions TLN1 PIP5K1C MET TYROBP RND1 MYL12B FARP2 ARHGEF11 SEMA5A ARHGEF12 PLXNC1 PTPRC SEMA6A PLXND1 SEMA6D CFL1 SEMA7A RHOC PLXNA2 RHOB NRP1 PLXNA4 PLXNA3 ITGA1 ITGB1 HSP90AA1 LIMK2 CRMP1 LIMK1 PLXNB3 ROCK1 TREM2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 HSP90AB1 PLXNA1 ARHGAP35 CDK5R1 PAK1 FYN RAC1 PAK3 PAK2 PLXNB1 SEMA3A SEMA3E RRAS MYL6 SEMA4A SEMA4D MYL9 CDK5 RHOA FES ERBB2 ROCK2 MYH9 GSK3B MYH14 MYH11 MYH10 CD72 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.1 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%190322 FGFR4 ligand binding and activation FGF19 FGFR4 FGF1 FGF16 FGF2 FGF18 FGF4 FGF6 FGF9 FGF20 KLB FGF23 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.3 Interleukin-6 signaling IL6ST JAK1 SOCS3 STAT3 PTPN11 STAT1 TYK2 IL6 CBL IL6R JAK2 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.1 PTEN Loss of Function in Cancer PTEN NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 80%420597 Nectin Necl trans heterodimerization PVR CADM3 CADM1 NECTIN2 NECTIN4 NECTIN3 NECTIN1 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.5 Interleukin-2 family signaling CSF2RB CSF2RA PIK3CD PIK3CB LCK SHC1 STAT1 INPP5D PIK3R3 GAB2 INPPL1 PIK3R1 LGALS9 PIK3CA SOS1 IL21R STAT4 SYK JAK3 CSF2 JAK1 PTPN6 IL5RA STAT3 GRB2 PIK3R2 IL21 SOS2 PTK2B IL2RG IL9R IL15RA IL3RA STAT5A IL2 HAVCR2 STAT5B IL3 IL2RA IL5 IL2RB IL15 IL9 JAK2 RAS PROCESSING%REACTOME DATABASE ID RELEASE 80%9648002 RAS processing ICMT KRAS ARL2 USP17L2 ABHD17C BCL2L1 ABHD17B ABHD17A LYPLA1 NRAS FNTA PDE6D FNTB PRKCQ PRKG2 HRAS GOLGA7 CALM1 ZDHHC9 RCE1 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.3 GRB7 events in ERBB2 signaling NRG1 ERBB2 GRB7 NRG2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 80%9709570 Impaired BRCA2 binding to RAD51 RAD50 RAD51 RAD1 DNA2 RFC5 RFC3 HUS1 RFC4 BLM RFC2 RPA2 MRE11 RHNO1 WRN RPA3 ATRIP RAD17 ATR SEM1 BRCA2 RAD9B RAD9A BRIP1 KAT5 RPA1 EXO1 ATM RBBP8 NBN BARD1 TOPBP1 RMI2 RMI1 TOP3A BRCA1 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 80%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.2 Post-chaperonin tubulin folding pathway TUBA1B TUBA4B ARL2 TUBA4A TUBB2B TUBA1A TUBB2A TBCD TBCC TBCB TBCA TUBB4B TUBB4A TUBAL3 TUBA3E TBCE TUBB6 TUBA3D TUBB3 TUBB1 TUBA3C TUBA8 TUBA1C CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 80%9707564 Cytoprotection by HMOX1 HELZ2 NFE2L2 COX6C HMOX1 LRPPRC ALB CREBBP TXNIP HBA2 TACO1 COX6A1 COX6B1 COX19 COX16 COX18 FABP1 BACH1 COX11 COX14 NCOA2 CHD9 NLRP3 STAP2 CYCS ABCC1 COX20 COX4I1 RXRA PTK6 BLVRB BLVRA HM13 NCOR2 HDAC3 TGS1 NCOR1 TBL1XR1 SIN3A TBL1X NDUFA4 SMARCD3 CARM1 MT-CO1 MED1 COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 MAFK STAT3 SURF1 NCOA1 HMOX2 COX7B HBB NCOA6 PPARA COX7C COX8A COX5B COX5A SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 80%162582 Signaling Pathways BMI1 CCL19 CCL22 CCL20 RDH5 SEC13 RING1 NUP133 PARP1 SMC1A AAAS NUP160 RNF2 HDAC7 NUP85 RAD21 NUP43 RANBP2 CBX8 PHC2 PHC1 CBX4 CBX2 IL3RA PHC3 PML STAG1 STAG2 NUP37 BTC NRG3 NRG4 NRG2 HBEGF EREG MTR OPRD1 NCBP1 NCBP2 CXCR1 CXCR2 SRRM1 DDX39B ELMO1 C5AR2 C5AR1 CSF2RB CSF2RA CXCL8 CXCL1 CXCL2 OPRM1 S1PR1 AGO3 AGO4 AGO1 AGO2 NTRK1 NTRK2 KAT5 TRPC7 TRPC6 TRPC3 CCNK FASN LRIG1 TLE5 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 SGK1 PRKCG PRKCA PRKAA1 PRKAA2 CAB39 CAB39L CCNT2 YWHAB PRKAG1 CCNT1 PRKAG2 PRKAG3 PRDM1 RPTOR STK11 EEF2K RGS17 AKT2 RGS19 RGSL1 MLST8 EIF4EBP1 RGS16 AKT1 RGS4 SLC38A9 RGS20 EIF4E PRKCH EIF4B PRKAB2 STRADA MAPKAPK5 PDHB STRADB RPS6 TSC2 TSC1 PRKAB1 MTOR FKBP1A PDK4 PPM1A PDK3 RRAGA RRAGC DLAT PDK2 RPS6KB1 PDK1 RHEB PDHX RRAGB PDHA2 AKT1S1 PDHA1 RRAGD LAMTOR2 LAMTOR1 CDK9 LAMTOR4 LAMTOR3 LAMTOR5 DISP2 SCUBE2 EIF4G1 TGFB1 TGFBR1 TGFBR2 ITGB1 NCKAP1 CYFIP1 TRIO NCF1 TFRC NCF2 SNAP23 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 PREX1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 VAV2 BCR TIAM1 IGF2BP1 DEPDC1B RAPGEF1 CDC42EP1 RASGRF1 DSG2 RAB7A EPHA2 VAMP3 GARRE1 AMIGO2 NOXO1 PIK3R2 ARHGAP17 SLC1A5 ARHGAP15 LMAN1 ABR ARHGAP21 ZDHHC7 PGRMC2 RACGAP1 CPT1B CRABP2 SLITRK3 CRABP1 NHS RDH14 ABL2 RDH13 SLITRK5 IGF1R NCKAP1L PPID WASF1 CAV2 SRGAP2 WASF2 SDR16C5 ALDH1A3 YKT6 ALDH1A2 PAK4 IL32 SCD GIT2 ALDH8A1 JAG1 CAV1 MCAM MCF2 ARHGAP26 BAIAP2 ST3GAL6 MPP7 VANGL1 ARHGAP32 DIAPH3 TAOK3 ABI2 ABI1 NOXA1 NOX3 ESYT1 NOX1 FERMT2 S100A9 S100A8 FKBP4 USP7 USP9X HDAC6 DNAJB1 OTULIN FGF16 FGF7 FST FGF18 DUSP4 PTGES3 DUSP3 PPP2R5D VRK3 DUSP6 FOXA1 DUSP7 TLE3 PGR MAPK7 DDX5 PPP2R1B JUND APC GREB1 SP1 CHD1 AXIN1 NR5A2 TFF3 KNG1 TFF1 GTF2A1 KANK1 WDR83 C1QBP GTF2A2 CXXC5 RCE1 ICMT KDM4B USF2 RGL3 FGB USF1 RGL1 FGA ZNF217 RGL2 VWF PEA15 FOSB EBAG9 IL17RD RAPGEF2 USP17L2 RASGEF1A F2R ABHD17C ABHD17B FGG ABHD17A F2 SPINT1 F3 HPN SPINT2 HGFAC SSTR3 PF4 MCHR1 RHO GNA12 PPP1R15A USP15 LTBP4 NEDD8 LTBP2 LTBP3 LTBP1 ITGB8 PMEPA1 ITGB6 TGFB2 TGFB3 UCHL5 SMAD7 BAMBI ITGA8 STRAP AMER1 RPS27 PLCB3 PLCB4 PLCB1 NPHP4 PLCB2 H3-3B SIRT6 ELF3 NOTCH2 NOTCH3 NOTCH4 GAST TERT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L H3-4 ATP2A3 ATP2A2 ATP2A1 PPP2R5E PRKG2 PTGIR PPP2R5B PPP2R5A PPP2R5C PDE5A PDE1B PDE1A ITPR1 ITPR2 ITPR3 PDE11A NOS3 PDE2A MAPK14 PDE10A PTPN6 IRAK1 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 SMAD2 SMAD3 KDM1A DOCK11 KIF5B KIF5A MYB GATA3 KLC1 KLC4 KLC3 KLC2 GZMB ABL1 KIF18A CDK5 AKR1C3 RCOR1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 DOCK7 CYSLTR1 FNTA FNTB CAPZB H3C8 WWC1 YBX1 HEY1 HEY2 KIF2A HES5 DLGAP5 PTCRA HEYL KIF2C TACC3 KIF2B RXRB DOCK2 UGT1A3 DOCK1 HDAC2 H3C15 MFN1 MFN2 SH2B3 SH2B2 CENPE TCF7L2 TCF7L1 MYC TCF7 LEF1 CTNNB1 RUNX3 HGS MDM2 ABHD12 KIT SRMS DAGLA PTK6 ABHD6 DAGLB KDM4A CLTC CLTA PPP5C PIK3CG PIK3R5 MYLIP HSPB1 ABCA1 NR1H2 APOC4 NR1H3 APOC1 THBS2 THBS1 NGFR ARHGDIA NGF RHOA BUB1B CDC20 BUB3 MAD2L1 IL6 MYH9 SMPD3 SMPD2 CDC73 LEO1 PPP3CC CSNK1G2 TJP1 PSAP FZD7 IGF2 VAPB BCAR1 MEMO1 ST3GAL4 GOLGA7 ST3GAL3 PTPRK SPRY1 ZDHHC9 APH1A PSENEN APH1B PSEN2 B4GALT1 ATP6V1A TCIRG1 INS ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 ATP6V1F ATP6V1C2 ATP6V1G1 CDC14B ETV4 ATP6V0B ATP6V0E1 MAPK6 ATP6V1G2 MAPK4 ATP6AP1 SEPTIN7 AMHR2 INSR ATP6V1B2 ZFYVE16 PARD3 ATP6V0D1 GDF2 ATP6V0C ATP6V0D2 SMAD9 ATP6V1B1 CGN SMAD5 BMPR1B BMPR1A ACVRL1 BMPR2 NOG GREM2 APOD AVP DLD DDX4 ROCK1 TNFAIP1 RND3 MUC13 FLOT2 WDR6 CKB FAM83B DSP ANKRD26 AXIN2 DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F PTPN13 CKAP4 KTN1 NISCH CCDC88A VANGL2 UBXN11 DLG5 CPD KCTD13 DSG1 PKP4 RBMX PICALM MATK FLT3 GSK3A BAD CASP9 MKRN1 AKT3 PELP1 DTX4 GRAP2 PLCG2 JUN VAV3 SYK FOS MAPK8 EPO IRS2 EPOR PLAT THBS4 THBS3 PDGFD CASP2 CYFIP2 ITSN2 ANKLE2 WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MYLK PREX2 GJA1 WDR91 EPSTI1 ANKFY1 CEP97 FNBP1 STARD8 PRKCD MRTFA FRS2 FRS3 AR DYNC1LI1 DYNC1LI2 MYL6 DAAM1 WDR81 MYL9 NGEF MTMR1 SHMT2 CDCA8 IQGAP1 IQGAP2 PRKCZ IQGAP3 SKA1 SKA2 RHOT2 RHOT1 MYO6 SFN HMOX2 STARD13 DGKG JUP NTF4 DGKE FAM135A BDNF DGKD HNRNPC GNAT2 DGKB PRKG1 CDC42SE2 DGKA ARHGAP9 WNT5A DGKZ ARHGAP8 DGKQ NLK ARPC1B WNT11 DGKK ARPC1A DGKI PDE6B OSBPL11 DGKH PDE6A LRRC1 FZD3 ARHGAP4 FZD2 FZD5 NUF2 NUDC PDE6G RRAS2 FZD4 GMIP FZD6 GNAO1 DYNLL2 LRRC41 CIT INCENP TPH1 CDC42EP5 CDC42EP4 MAP2K5 CDC42EP3 CDC42EP2 PLIN3 PKN3 GPS1 FGD1 FGD2 FGD3 RAB4A FGD4 FGD5 CHN2 CHN1 FLNA STX5 FARP2 FARP1 KIDINS220 WWP2 DEF6 PXN ULK3 DZIP1 WDR11 EFCAB7 LETM1 IQCE TMEM59 CENPF EVC TAOK1 GAS8 SPOP SHKBP1 PKN2 EVC2 GOPC FILIP1 PKN1 UHRF1BP1L FAM13B ACTA2 PLXND1 FAM13A MSI2 PPP1CC STK10 SLK CFL1 DUSP16 POTEE MEN1 DUSP10 GOLGA8R TPM4 TPM3 DUSP8 RALGAPA1 DUSP9 CDC25C FAM91A1 MRAS TEX2 ARMCX3 CLIP1 OBSCN PHIP MAD1L1 RHOBTB3 LIN7B SHOC2 RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 PLXNA1 DVL3 SRGAP3 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 NSFL1C ARPC2 ARPC3 COPS2 PLXNB1 NF2 MAP3K11 ARHGAP11A ZNF512B ARHGAP11B ROR1 RASGRF2 TAGAP ROR2 PRICKLE1 EFHD2 NCK2 SPDL1 NCK1 ACTR3 PLEKHG3 ACTR2 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 RANGAP1 NIPSNAP2 ARFGAP2 BIRC5 PIK3C3 EVL PPP1R12B SOS2 ROCK2 GABBR2 SRF GABBR1 NSL1 PARD6B PARD6A ARL13B SH3BP1 CSK RBBP6 WHAMM WASF3 RNF20 PPP1R14A NDUFA5 PCDH7 CDC42BPB CDC42BPA MYO19 PRC1 CPNE8 GOLGA3 BAIAP2L2 ACTN1 TIAM2 ZW10 CCDC88C CXXC4 SPATA13 SST BTK PFN1 CFTR ROPN1 LFNG PFN2 GRB7 TMEM87A PIK3R4 PIK3R3 TWF1 SHH KLK3 HHIP KALRN BOC MYL12B DSN1 IHH GAS1 SCFD1 SCAI SPTBN1 RCC2 STAM ZWINT PTK2 NET1 GRP ANLN AHCTF1 FAF2 KIF14 WASL SH3RF1 FFAR4 AKAP12 FFAR1 AKAP13 XPO1 HDAC4 HINT2 SH3PXD2A RAC2 SPTAN1 NDEL1 NCOA2 CCDC115 RHOG RHOH RHOF RHOC RHOD RHOB ARHGEF9 CTTN RHOJ ARHGEF3 ARHGEF4 RHOU ARHGEF1 TAX1BP3 ARHGEF2 RHOV ARHGEF7 RHOQ DBN1 ARHGEF5 ARHGEF6 MIS12 WAS TRAK1 TRAK2 SAMM50 PLEKHG4B EMC3 CTNNA1 PAK6 DYNC1I1 PAK5 BCAP31 CAVIN1 MTX1 MYO9B MYO9A PENK DLC1 TRIP10 RAB9A B9D2 RAB9B SPC24 SPC25 ERCC6L STEAP3 RTKN PRAG1 ZWILCH ARHGDIG CHRDL1 ACTG1 SYDE2 ARHGAP44 ARHGAP40 BASP1 VGF KNTC1 ARHGEF40 RALBP1 KCTD3 ARHGAP45 SGO1 ALDH3A2 SGO2 ELMO2 STAM2 ARHGEF26 FSTL1 ARHGEF25 FSTL3 ARHGEF28 ARHGAP19 ARHGAP18 PMF1 LAMB2 TOR1AIP1 ARHGAP12 NCKIPSD NOTUM ARHGAP22 ARHGAP20 RHPN1 MYH14 MYH11 RHPN2 ECT2 NPY MYH10 CPSF7 ACBD5 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 CDH5 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 DIAPH2 ARHGAP31 DNMBP ARHGAP30 SOWAHC ARHGEF10L RND2 HDAC10 RND1 LMNB1 YWHAQ MCF2L HDAC8 DBT FLOT1 YWHAH ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 ARAP1 YWHAZ SENP1 ZAP70 ARHGAP10 ALS2 GFOD1 PEAK1 NDUFS3 CCDC187 RAP1GDS1 PPP1R1B STAP2 MOSPD2 ADD3 PDE4B FAM169A STK4 STK3 UACA SAV1 AURKB GNA13 MOB1B TRA2B LATS1 PTK2B MOB1A LATS2 STOM AMOTL2 VHL AMOTL1 BUB1 FZD10 CLASP2 CRHBP SPEN KDM4C FZD9 LIMK2 UCN3 LIMK1 UCN2 PTCH2 HSPE1 ADGRE1 SLC4A7 ADGRE2 FMNL3 MAPK11 FMNL1 FMNL2 ACTC1 VIM E2F5 COL4A2 COL4A1 COL6A2 CDKN2B CSN2 COL4A4 STMN1 ADAP1 MXD4 COL6A1 COL4A3 COL6A3 COL4A5 CCL4L2 COL6A6 COL6A5 RGS5 MAP2K1 RGS2 RGS3 RGS1 RGS8 PCP2 YES1 GPSM1 GPSM2 CHRM2 GPSM3 CHRM3 CHRM1 RGS18 CHRM4 RGS14 CHRM5 RGS13 HTR2B RGS21 HTR2C RGS22 ADRB1 RGS10 ADRA1D RGS12 SHB ADRB2 HTR2A SH2D2A HTR4 AXL CILP ADRA1B IRS4 ADRA1A TAAR3P MST1R CXCL6 HTR6 PTPRO CXCL9 MST1 HRH1 CXCL13 HTR7 PTN CXCL3 MYCN HRH3 CXCL5 HRH2 CX3CL1 HRH4 CXCL16 DRD1 CCRL2 DRD2 CCR9 DRD3 CCR8 DRD4 CCR7 DRD5 CCR4 TAAR8 CCR3 HTR1E XCL2 TAAR9 XCL1 HTR1F CX3CR1 TAAR6 CCL13 HTR1D CXCR5 HTR1A CXCR6 TAAR5 CCL7 HTR1B CXCR3 TAAR2 CCL1 CCL17 ADRA2C HTR5A CCL16 TAAR1 CCR10 CCL25 ADRA2B XCR1 ADRA2A CCL21 GPR143 CXCL11 ADRB3 KLB ACKR4 ACKR3 FGFRL1 ACKR2 TIAL1 CCL28 PTBP1 FGFBP3 CCL27 FGFBP1 RBFOX2 FGFBP2 GTF2F1 GTF2F2 HNRNPH1 ESRP2 ESRP1 ANOS1 FLRT2 FLRT3 FLRT1 HNRNPA1 TIA1 GNAL GALNT3 HNRNPM FGF19 HNRNPF FGFR4 KDM3A KDM1B ABCG8 ABCG5 ARL4C EEPD1 TBP OXTR AVPR1B OXT AVPR1A CYP26C1 ADH1A SEL1L DERL2 ERLEC1 OS9 SYVN1 NELFB CHEK1 PDE6D MTMR4 CITED1 IRS1 PIK3CD PIK3CB AREG PDGFRB PDGFRA HGF FLT3LG GAB2 MET PDGFB TGFA CD19 TRAT1 ESR1 ESR2 EPGN STRN PIK3AP1 PPP1CA FABP5 FABP6 FABP7 PLIN1 NRP1 ITGA2 DHRS4 PRMT1 RBL1 E2F4 CARM1 FOXO3 ELK1 UHMK1 CREB1 BCL2 PHB1 LYPLA1 ITGB3 ZDHHC21 ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 APBB1IP CNKSR1 KRAS TLN1 RAF1 VCL HDAC11 DNER TLE4 TLE2 TLE1 DTX1 DTX2 HDAC9 DLK1 TBXA2R INHBB INHBA FFAR3 GPR31 FFAR2 CTNND1 PIK3R6 TNS4 TNS3 GPNMB LRRK2 LAMC3 LAMA4 ITGA3 ATF2 AHCYL1 PIP4K2A PIP4K2B TRIM27 PIP4K2C IER3 PRKCE TRIB3 PDE1C MAPKAP1 PIP5K1A PIP5K1B ID1 PIP5K1C EGR1 MOV10 SNAI1 SNAI2 EZH2 MECOM PPARG PHLPP2 PHLPP1 XIAP FKBP5 PRKX CAMKK1 CAMKK2 RICTOR MBD3 SUZ12 GATAD2B GATAD2A RNF146 NEDD4 FRK ATN1 SALL4 MAF1 SMAD1 KPNA2 SMAD6 BMP2 TNKS FOXO6 FOXO4 FOXO1 GRK2 THEM4 CBX6 NR4A1 NBEA MYD88 PRR5 PTEN CHD4 CHD3 NR2E1 EED IRAK4 USP13 HDAC5 MTA1 TNKS2 MTA2 MTA3 TNRC6C REST RPS6KB2 STUB1 TNRC6A OTUD3 PTPRS TNRC6B BAG4 STAT1 ANGPT1 TEK SMAD4 RALA JAK1 TYK2 ALK MEF2A MEF2C RPS6KA3 RPS6KA5 TAS2R7 RPS6KA2 TAS2R60 RPS6KA1 TAS2R40 TAS2R9 TAS2R41 TAS2R8 TAS2R20 TAS2R42 TAS2R43 TAS2R45 SQSTM1 TAS2R46 GRM3 GPRC6A GRM2 GRM5 GRM4 GRM7 GRM6 GRM8 TAS2R1 TAS1R2 RIPK2 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 CASR TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 PTPN18 TAS2R16 TAS2R39 PTPN12 TAS2R19 PTPN7 PTPN2 IL6R RUNX1 RARA CBFB RXRA SFPQ KHDRBS1 KHDRBS2 KHDRBS3 VPS29 WNT2B WNT8A WNT8B VPS26A SNX3 WNT6 PORCN VPS35 WNT2 TMED5 DHH WNT3 WNT4 WLS WNT10A WNT5B WNT3A WNT7B WNT9B PBX1 WNT7A WNT9A WNT16 TMED2 RFNG POGLUT1 POFUT1 MFNG MDK TRRAP SOX3 FRAT1 FRAT2 SOX17 SOX6 SOX7 SOX4 SOX13 DKK1 DKK2 DKK4 SFRP1 SFRP2 HECW1 FZD1 FZD8 RSPO2 RSPO3 RSPO1 RSPO4 KREMEN1 KREMEN2 WIF1 RYK LGR6 LGR5 LGR4 USP8 RNF43 CTNNBIP1 MEF2D PYGO1 PYGO2 NAB1 KLHL12 NAB2 BCL9L BCL9 YY1 CHD8 USP34 CBY1 MAG SOST DACT1 LRP5 LRP6 ZNRF3 SH3GL3 ARC TRIB1 KMT2D SHC2 SHC3 RRAD RALGDS EGR3 EGR4 FOSL1 ID2 ID4 ID3 DNAL4 LYL1 RALB ASCL1 RIT1 RIT2 CDK5R2 DRAP1 CXCL12 PTPRA ITGAV SPTB ITGA5 SRY DUSP5 CCNC DUSP2 DUSP1 CER1 PAQR3 PTPN3 HHAT FOXH1 SPARC NTRK3 EPAS1 NTF3 PCK1 WWTR1 EGR2 SMARCA4 AGTR1 ARTN NRP2 PPP3CB NCOA1 NCOA3 YAP1 TACR1 EPS15L1 NRTN SH3GL2 ARF6 DOK1 GGA3 SPTA1 WNT1 CNTN1 LAMA2 LAMA1 ACVR1B ACVR1C ACVR2B ACVR2A MAPK12 MAPK13 MED1 WNT10B RET RARG CLTB ASH2L EPS15 TCF12 RARB SH3GL1 TNF GRB10 IAPP CDK8 EPN1 AMH NPFFR2 NPFFR1 RXFP4 RRH GRPR RXFP3 RBBP5 EDNRA EDNRB OXER1 PROK2 PROK1 CMKLR1 UTS2R NPFF GPR37L1 PDYN LEP TRHR UTS2B KEL AGTR2 SOX2 PTGFR LPAR1 LPAR2 SOX9 LPAR3 LPAR4 CDON NLN GALR3 GALR2 GALR1 NPBWR1 NPBWR2 PPY HCRT NTSR1 NTSR2 GPR17 NMB NMBR LPAR5 LPAR6 SPTBN4 NMS SPTBN5 GPR183 NMU PNOC GNRH2 GNRH1 GPR18 PTGDR2 QRFP MLN BRS3 GPR132 CCKAR OPN1LW GNRHR SPTBN2 OXGR1 EDN1 GPR37 EDN2 EDN3 GPR35 TACR2 TACR3 GAL OPN1MW SH3KBP1 CCKBR RGR NPB PLPPR1 PLPPR2 PTGER1 PLPPR3 PLPPR4 PTGER3 PLPPR5 PROKR1 PROKR2 NPW KISS1R PRLH P2RY12 P2RY13 P2RY10 P2RY14 GFRA1 GPR55 GPR4 AGT GFRA3 XK GFRA2 F2RL1 F2RL2 F2RL3 GFRA4 GPR68 GPR65 PMCH NPY2R ADORA3 ADORA1 GHSR CXCR4 NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 NTS MCHR2 RANBP9 HCAR2 HCAR3 HCAR1 TAC3 TAC1 OPN4 OPN3 CDK5R1 OPN5 PYY NMUR2 NMUR1 MLNR ECE1 ECE2 TRH LTB4R BDKRB2 BDKRB1 PRLHR QRFPR INSL5 NPY5R GNRHR2 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 P2RY6 CNR2 P2RY4 CNR1 P2RY2 P2RY1 PSPN S1PR3 S1PR2 S1PR5 S1PR4 GDNF OPRK1 CCK FES HCRTR2 HCRTR1 APLN KISS1 OPN1SW ACKR1 DNM1 DNM2 DNM3 NCAM1 BMP10 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 PDE8B PDE8A PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL GIPR LHB GPR83 GPR84 CRHR1 CRHR2 GHRHR GRK3 MC2R CALCR GRK5 GRK6 CGA GPR15 MC1R PDE3A RLN2 RLN3 GPR27 GLP1R GPR25 PDE3B GPR20 ADM PTH1R MC4R GPER1 PDE4A INSL3 TSHB GPR39 GPR32 FSHB PDE4D GLP2R AVPR2 PDE4C GPBAR1 PTH2R GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 PTPRU NPSR1 FER GRAP RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 NPS GPR150 GPHA2 P2RY11 SCTR GCG TSHR POMC GHRH ADM2 MC5R PDE7B PDE7A VIP RAMP1 GPHB5 CYP26A1 CYP26B1 RNF111 RBCK1 NEDD4L CAMK2B CAMK2D ACTN2 SRC CAMK2A NRG1 GRIN2B GRIN1 GRIN2D DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G BAX WWP1 CSNK2A1 CSNK2A2 CSNK2B KCTD6 RNF41 PLD1 PLD2 CUL5 UCN SOCS3 SOCS1 IGF1 SMURF2 SMURF1 UBE2M PLA2G4A GFAP MGLL GPAM GABRB3 GABRB2 GABRB1 YWHAE GABRG3 CCP110 GABRG2 PPP1CB GABRQ GABRA1 PPP2R1A BTRC PRKACA YWHAG SKP1 OFD1 HSP90AA1 PPP1R12A SERPINE1 NR3C1 CSNK1E CPT1A DYNLL1 CKAP5 HIF1A MAPRE1 UBA52 NRIP1 PAFAH1B1 DYNC1I2 CUL1 HEBP1 ANXA1 MT-RNR2 FPR1 FPR3 UBB FPR2 CTBP2 CTBP1 PRKAR2B PRDM4 SPPL2B UBC SPPL2A TNFSF10 PRKCI RPS27A USP4 USP2 OMG CLASP1 CLIP3 NSMAF DYNC1H1 BEX3 MAGED1 RTN4 NDE1 BCL2L11 SHARPIN PLK1 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 TNFRSF10B TNFRSF10A CDK1 TNFRSF10D TRADD STAT5A OTUD7B STAT5B FASLG AATF RACK1 PTPN11 TRAF1 SORCS3 TNFRSF1A RBX1 BIRC2 BIRC3 RNF31 JAK2 LINGO1 IKBKB USP21 PSMD8 CFLAR PSMD9 FAS ATF1 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 C3AR1 PSMD1 IKBKG MAP3K7 CHUK PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 JAK3 PSMA7 RELA RAPGEF3 RAPGEF4 PSMB10 PSMA8 PTAFR PSMB6 PSMB7 PPARD PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SKI PSMC2 STAT6 NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 SIN3A CD274 CAMK4 GPS2 TBL1X SHC1 EGF GAB1 PIK3R1 CBL EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 ITGB5 HRAS CDH1 ADAM10 ADAM17 IL2RG PSEN1 IL2RA KLK2 IL2RB NCSTN COL9A1 COL9A3 CRKL COL9A2 LAMC2 LAMC1 TRIM33 CASP3 CTSD MMP7 MMP2 MMP3 PPBP MMP9 LAMA5 PPP3CA LAMA3 PLG FURIN SPP1 LAMB3 CMA1 LAMB1 RXRG H2AX H2AB1 H2AC19 TGIF1 H2AC14 H2BC12L TGIF2 H2BC21 RUVBL1 H2BU1 RAG2 H2AC8 RAG1 H2AC6 H2AC7 KNL1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ITGB3BP CENPA CENPC RBBP4 RBBP7 H2AZ1 H2BC9 CENPT H2AZ2 CENPU MUC20 H4C9 H2BC8 ADGRE5 H2BC5 ADGRE3 H2BC3 H2BC1 CENPH CENPI H2AC20 CENPK CENPL CENPM CENPN TEC CENPO CENPP CENPQ CENPS UBE2D1 NFATC1 PRKCQ RASGRP2 RASGRP1 RASGRP4 CSF2 IL5RA LYN TAB3 TAB2 TAB1 SKIL RAB6A RAB4B PDPK1 BCL2L1 TRAF6 CRK IFT172 PRKACG PRKACB DYNC2H1 RPGRIP1L IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 INTU KIF3A TTC21B ATP1B4 PRKAR2A PTCH1 IFT122 FUZ ADCY10 MKS1 GNAS GSK3B GLI1 GLI3 GLI2 IFT52 SUFU IFT57 IFT140 KIF7 WDR35 CDC14A NUMB ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 WDR19 ITCH CREBBP NOTCH1 MAML2 TLR9 MAML1 RBPJ KAT2B KAT2A SNW1 EP300 HES1 MAML3 MAMLD1 IL33 IL1RL1 TP53 SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 ADH4 RASA4 RASA1 RASA2 ADH1C CUL3 RASAL1 ALDH1A1 RASAL2 RASAL3 DAB2IP POU2F1 NF1 KBTBD7 RANBP10 C3 F11R WWOX APP HSP90AB1 UBE2D3 TNFAIP3 ADAM12 CASP8 CASP10 TRAF2 ZRANB1 TAX1BP1 C5 RIPK1 FADD S100B GNAT1 CYLD SAA1 PIN1 CDKN1A CDKN1B CCND3 CCND1 E2F1 E2F3 MAPKAPK3 MAPKAPK2 TFDP1 RDH11 RDH10 TFDP2 RDH16 SOCS6 CDK4 CCNE1 CDK2 CXCL10 BRAF PPP2CA PPP2CB MKNK1 MAPK1 SPRY2 MAPK3 PTPRZ1 CCL5 CCL4 CCL3 CCL2 AAMP PTPN1 CD86 CDC42 PAK1 LCK CD80 DHRS3 CD28 FYN RAC1 PAK3 DHRS9 PAK2 VAV1 PAG1 CCR1 VCP GPC5 PTPRJ CCR6 CCR5 CCR2 CETP PCSK6 PCSK5 APOE APOC2 ANGPTL3 P4HB ABCG1 ACTB CD55 RGS9 RGS6 RGS7 ARL2 GNG10 GNG12 CCL3L3 GNG11 GNG13 CCT6A GNAQ GNB2 RASGRP3 GNB1 GNB4 IL2 GNB3 IL3 IL5 GNB5 GNGT1 TUBA1B GNGT2 CCT2 SPHK1 GNA14 GNA15 JUNB GNG3 GNG2 GNG5 GNG4 GNA11 PPP3R1 GNG7 GNG8 CCT7 STAT3 RGS11 ERBB2 ERBIN AP2S1 ATP6V1H AP2A1 AP2B1 AP2A2 AP2M1 FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA NUP107 FCER2 SMC3 CCL11 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.1 The phototransduction cascade PRKCA SAG SLC24A1 NMT1 GUCA1B GRK1 GUCA1A GUCY2D GUCA1C GRK7 PRKCQ GUCY2F CALM1 CNGB1 RHO RCVRN PPEF1 METAP1 METAP2 FNTA FNTB GNAT1 GNB1 PDE6B PDE6A NMT2 PDE6G CAMKMT RGS9BP GNGT1 CNGA1 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.1 Complex I biogenesis NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 NDUFB10 NDUFB11 NDUFAB1 COA1 NDUFB8 NDUFC2 NDUFS3 NDUFA13 NDUFA11 NDUFA12 NDUFA10 MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 NDUFC1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 ACAD9 NUBPL NDUFV3 NDUFV2 NDUFV1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 TMEM186 TIMMDC1 ECSIT TMEM126B NDUFA5 NDUFAF6 NDUFAF7 NDUFAF4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.3 Amino acid transport across the plasma membrane SLC7A11 SLC7A10 SLC7A5 SLC7A6 SLC36A1 SLC7A9 SLC3A1 SLC36A2 SLC7A7 SLC7A8 SLC43A2 SLC43A1 SLC3A2 SLC7A1 SLC7A3 SLC25A29 SLC36A4 SLC6A19 SLC6A18 SLC1A5 SLC6A15 SLC38A1 SLC6A14 SLC6A12 SLC6A20 SLC1A4 SLC6A6 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC16A10 VLDL CLEARANCE%REACTOME%R-HSA-8964046.1 VLDL clearance VLDLR APOC4 APOBR APOC1 LSR APOB DEGRADATION OF DVL%REACTOME%R-HSA-4641258.2 Degradation of DVL KLHL12 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DACT1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 CUL3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DVL1 DVL2 DVL3 UBA52 UBB UBC RPS27A HECW1 RBX1 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.6 EGFR downregulation CDC42 AREG EPS15 SH3GL2 EGF SH3GL3 UBA52 CBL TGFA EGFR SH3KBP1 EPGN STAM SH3GL1 BTC HBEGF UBB EREG PTPRK SPRY1 UBC RPS27A PTPN12 SPRY2 STAM2 HGS ARHGEF7 EPN1 PTPN3 EPS15L1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 80%447043 Neurofascin interactions NFASC CNTNAP1 CNTN1 DCX NRCAM ANK1 SDCBP EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.1 EPH-Ephrin signaling MYL12A KALRN MYL12B ACTB GRIN2B GRIN1 CLTCL1 PTK2 VAV3 WASL MMP2 MMP9 RASA1 LYN CFL1 LIMK2 LIMK1 EPHB6 ARHGEF7 ROCK1 EPHB2 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 CDC42 CLTC EPHA6 PAK1 EPHA8 ARPC4 ARPC5 ITSN1 CLTA FYN RAC1 PAK3 ARPC2 PAK2 ARPC3 GIT1 EPHA1 EPHA3 EPHA10 HRAS NCK2 SDC2 EFNA5 ACTR3 VAV2 EFNA4 ACTG1 ACTR2 TIAM1 MYL6 EFNB2 SDCBP EFNB1 MYL9 EFNB3 NGEF EFNA1 EPHA2 EFNA3 YES1 EFNA2 RHOA APH1A PSENEN ROCK2 APH1B ADAM10 PSEN2 AP2S1 ARHGEF28 AP2A1 AP2B1 AP2A2 MYH9 AP2M1 DNM1 ARPC1B ARPC1A PSEN1 MYH14 MYH11 MYH10 NCSTN CLTB HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 80%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNG CHRNA4 CHRNE CHRNB2 CHRND CHRNB4 CHRNA3 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.4 Neurexins and neuroligins GRM5 GRIN2C GRIN2B GRIN1 GRIN2D GRIN2A DLG2 DLG3 DLG4 EPB41L1 EPB41L3 SYT2 HOMER3 SYT9 EPB41 SHANK3 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 LIN7B SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN APBA3 APBA2 STX1A SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 CASK NRXN1 NRXN3 LIN7A NRXN2 LIN7C APBA1 PDLIM5 NLGN4Y NLGN4X SHARPIN SYT12 SYT1 SYT10 DBNL PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.3 PINK1-PRKN Mediated Mitophagy TOMM40 RPS27A SQSTM1 UBA52 PRKN MTERF3 ATG5 MAP1LC3B TOMM70 MAP1LC3A MFN1 MFN2 TOMM7 TOMM5 TOMM6 ATG12 VDAC1 TOMM20 TOMM22 UBB PINK1 UBC VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 80%196843 Vitamin B2 (riboflavin) metabolism FLAD1 ENPP1 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.7 Signaling by ERBB2 MEMO1 PRKCA PRKCE RNF41 DIAPH1 GRB7 FYN SHC1 CUL5 AKT3 EGF GAB1 PIK3R1 UBA52 SRC EGFR NRAS NRG1 PIK3CA CDC37 PLCG1 SOS1 AKT2 HRAS PRKCD BTC AKT1 NRG3 NRG4 NRG2 HBEGF UBB EREG UBC PTPN18 MATK RPS27A PTPN12 YES1 RHOA ERBB2 ERBIN HSP90AA1 PTK6 USP8 STUB1 RAF ACTIVATION%REACTOME%R-HSA-5673000.2 RAF activation RAF1 CAMK2B CAMK2D YWHAB SRC CAMK2A NRAS MAP3K11 HRAS CALM1 CAMK2G MAP2K1 BRAF PPP2CA PPP2CB PPP1CB PPP1CC PPP2R1A PPP2R5D PHB1 ARAF MRAS PPP2R1B PPP2R5E MARK3 SHOC2 BRAP MAP2K2 PPP2R5B KSR1 PPP2R5A PPP2R5C JAK2 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.1 Signaling by FGFR4 in disease PIK3CA PLCG1 SOS1 HRAS FRS2 FGFR4 GAB1 PIK3R1 NRAS GSD XV%REACTOME DATABASE ID RELEASE 80%3814836 GSD XV GYG1 GYS1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 80%72695 Formation of the ternary complex, and subsequently, the 43S complex RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA RPS3A RPS4Y2 RPS6 RPS27L RPS4Y1 RPS15A RPS3 RPS2 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPS27A EIF1AX EIF2S2 EIF2S1 EIF3M EIF2S3 EIF3K EIF3L EIF3I EIF3J EIF3G RPS4X EIF3H RPS15 EIF3E EIF3F RPS14 EIF3C RPS17 EIF3D RPS16 EIF3A RPS19 EIF3B RPS18 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 80%203754 NOSIP mediated eNOS trafficking NOSIP NOS3 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 80%112126 ALKBH3 mediated reversal of alkylation damage ASCC1 ASCC2 ASCC3 ALKBH3 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 80%177128 Conjugation of salicylate with glycine ACSM5 ACSM4 GLYATL3 GLYATL2 GLYATL1 ACSM2A GLYAT ACSM2B PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 80%164525 Plus-strand DNA synthesis PPIA FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 80%6781823 Formation of TC-NER Pre-Incision Complex GPS1 TCEA1 ZNF830 EP300 ISY1 USP7 HMGN1 UVSSA CCNH COPS7B COPS4 COPS7A UBA52 COPS2 COPS3 AQR COPS6 COPS5 COPS8 PPIE POLR2A POLR2B POLR2C POLR2D UBB POLR2E POLR2F ERCC8 POLR2G POLR2H UBC POLR2I POLR2J PRPF19 POLR2K CDK7 RPS27A POLR2L MNAT1 XPA GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CUL4A DDB1 ERCC3 ERCC2 CUL4B XAB2 RBX1 ERCC6 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) DUE TO BRCA1 LOSS-OF-FUNCTION%REACTOME%R-HSA-9701192.2 Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function RAD50 RAD51 RAD51B RAD51C DNA2 BLM MRE11 WRN SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 80%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB IKBKG CHUK PROTEIN REPAIR%REACTOME%R-HSA-5676934.2 Protein repair MSRB1 MSRA PCMT1 MSRB2 MSRB3 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 80%111933 Calmodulin induced events ADCY3 PRKCG ADCY2 PRKCA ADCY1 ADCY8 CAMK4 PDE1C PDE1B ADCY7 PDE1A ADCY6 ADCY5 CAMK2B CAMK2D CAMK2A PRKX PRKCD CAMKK1 CAMKK2 CREB1 PRKAR2B CALM1 CAMK2G PRKACG PRKACB KPNA2 ADCY9 GRK2 PRKAR1B PRKAR1A NBEA PRKAR2A PRKACA ADCY4 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 80%5603029 IkBA variant leads to EDA-ID NFKBIA IKBKB RELA NFKB2 IKBKG CHUK NFKB1 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 80%8875360 InlB-mediated entry of Listeria monocytogenes into host cell RPS27A EPS15 SH3GL2 STAM2 SH3GL3 MET UBA52 CBL HGS SH3KBP1 STAM SH3GL1 UBB UBC ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 80%379398 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.2 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 80%389957 Prefoldin mediated transfer of substrate to CCT TriC CCT3 CCT2 VBP1 TUBA4A TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 ACTB CCT6B TUBB6 TUBA3D TUBB3 TUBB1 TUBA3C CCT8 CCT7 CCT5 CCT4 TUBA1A TUBB4B TUBB4A CCT6A TUBA1C ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 80%193144 Estrogen biosynthesis HSD17B1 HSD17B2 CYP19A1 HSD17B14 AKR1B15 HSD17B11 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 80%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes IGFBP1 HDAC1 SREBF1 SIN3A ATXN3 HDAC2 PPARGC1A SMAD4 FOXO3 PCK1 G6PC1 POMC FBXO32 FOXO6 FOXO4 FOXO1 SOD2 CAT INS PLXNA4 RETN SMAD2 SMAD3 TRIM63 SIRT3 NPY ABCA6 GCK NR3C1 AGRP ALK MUTANTS BIND TKIS%REACTOME%R-HSA-9700645.1 ALK mutants bind TKIs EML4 PPM1B HIP1 CLTC STRN NPM1 ALK PRKAR1A EIF2AK3 BIRC6 BCL11A FN1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 80%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 80%196836 Vitamin C (ascorbate) metabolism CYB5A SLC2A3 CYB5R3 GSTO2 GSTO1 SLC23A2 SLC23A1 SLC2A1 DEUBIQUITINATION%REACTOME%R-HSA-5688426.3 Deubiquitination RNF123 USP15 NEDD8 H2AW H2AC17 H2AC12 H2AC1 UCHL5 H2BC18 SMAD7 H2AC21 POLB MUL1 UFD1 TAB1 AXIN2 CCNA2 CCNA1 TRAF6 SMURF2 TNIP2 ADRB2 USP30 KAT2B KAT2A EP300 IL33 USP18 RNF146 TP53 SMAD1 TNKS CCP110 FOXO4 NLRP3 KDM1B PTEN SMAD2 SMAD3 USP13 TNKS2 BARD1 OTUD5 NFRKB OTUD3 ACTR5 ACTL6A ACTR8 INO80C TNFAIP3 INO80B INO80E INO80D GATA3 HIF1A IFIH1 TFPT TRIM4 MCRS1 UBA52 INO80 TRIM25 TOMM70 SMAD4 OGT DDX58 AR TRAF2 UBB OTUB2 OTUD7A VCPIP1 TRAF3 ZRANB1 YOD1 UBC SUDS3 TNIP1 RNF128 RPS27A TNIP3 USP4 OTUB1 USP2 RNF135 USP10 RHOT1 DDB2 RIPK1 CDK1 CYLD OTUD7B MAVS BIRC2 BIRC3 TAF9B USP21 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SIAH2 IKBKG SKP2 MAP3K7 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 RIPK2 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 NOD1 PSMD11 NOD2 PSMD14 PSMD13 PSMA7 MYC PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 HGS PSMB8 PSMB9 NFKBIA SEM1 PSMC5 TGFB1 PSMC6 TGFBR1 PSMC3 MDM2 TGFBR2 PSMC4 MDM4 PSMC1 PSMC2 BABAM1 BABAM2 UIMC1 PTRH2 ABRAXAS1 BRCC3 ATXN7 SNX3 BAP1 TAF10 MAT2B PRKN ATXN3 ATXN3L VCP RAD23A JOSD2 JOSD1 RAD23B VDAC3 VDAC2 STAMBPL1 VDAC1 TOMM20 MYSM1 TRRAP USP17L4 USP17L5 USP17L8 RHOA CDC20 TADA2B USP33 WDR20 BECN1 USP17L3 USP17L1 CDC25A USP3 FKBP8 STAMBP TADA3 USP8 USP17L30 YY1 USP34 CFTR IDE USP17L21 USP17L20 ACTB USP17L22 ESR1 USP17L15 USP17L18 USP17L17 STAM USP17L19 USP17L10 USP17L12 USP17L11 USP17L13 USP7 CLSPN USP5 USP37 USP9X USP47 USP48 USP49 UCHL3 USP42 USP44 USP14 USP16 USP12 ABRAXAS2 USP19 USP24 USP25 USP26 USP20 USP22 USP28 APC AXIN1 UCHL1 SENP8 HCFC1 RCE1 FOXK2 FOXK1 MBD5 MBD6 ADRM1 ASXL1 ASXL2 H2AC19 USP17L2 H2AC14 H2BC21 RUVBL1 H2BU1 H2AC8 USP11 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 WDR48 H2BC9 H2BC8 STAM2 H2BC5 H2BC3 H2BC1 H2AC20 KEAP1 ARRB1 ARRB2 UBE2D1 BRCA1 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.2 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI1 GLI3 GLI2 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 80%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function RAD50 RAD51 RAD51B RAD51C DNA2 BLM MRE11 WRN SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 80%9669937 Drug resistance of KIT mutants KIT INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.6 Interleukin-17 signaling IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 IL17F FOS IL17C PPP2CA MAPK9 IL17A PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 MAPK3 PPP2R1A IL25 DUSP4 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 MAP2K3 DUSP7 UBE2N MAPK7 TAB3 PPP2R1B TAB2 SKP1 TAB1 FBXW11 MAPK11 TRAF6 UBA52 CUL1 ELK1 IL17RE IL17RC CREB1 IL17RB IL17RA UBB MAP2K1 UBC TNIP2 MAP3K8 IRAK2 RPS27A ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 80%417973 Adenosine P1 receptors ADORA3 ADORA1 ADORA2A ADORA2B SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 80%198745 Signalling to STAT3 NTRK1 NGF STAT3 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.4 ESR-mediated signaling CCND1 CCNT1 SRC SMC1A H3C15 AKT2 AKT1 CALM1 MYC MAPK1 RAD21 MAPK3 CDK9 RUNX1 CBFB STAG1 STAG2 HDAC1 KCTD6 H3-3B PDPK1 PPP5C EGF PIK3R1 EGFR NRAS PIK3CA HRAS BTC POLR2A POLR2B MED1 POLR2C POLR2D HBEGF EREG POLR2E POLR2F POLR2G POLR2H POLR2I S1PR3 POLR2J POLR2K POLR2L PIK3R2 SRF ZDHHC7 IGF1R PPID CAV2 ATF2 CAV1 CITED1 YY1 AREG AKT3 PIK3R3 CREBBP MOV10 TGFA GNAT3 ESR1 ESR2 NOS3 KAT2B EPGN GPAM FKBP5 STRN EP300 GTF2F1 PTK2 GTF2F2 FKBP4 CTSD JUN MMP7 FOS MMP2 MMP3 CXCL12 XPO1 KPNA2 MMP9 AGO3 NCOA2 GNG10 AGO4 AGO1 POU2F1 AGO2 PTGES3 GNG12 GNG11 GNG13 FOXA1 TLE3 PGR GNB2 DDX5 JUND GNB1 KDM1A KAT5 GREB1 GNB4 SP1 HSP90AA1 GNB3 CHD1 AXIN1 NR5A2 GNB5 TFF3 TNRC6C MYB TFF1 GTF2A1 KANK1 GNGT1 GTF2A2 TNRC6A PRMT1 CXXC5 KDM4B TNRC6B HSP90AB1 GNGT2 USF2 USF1 ZNF217 H2AX FOSB H2AB1 EBAG9 H2AC19 SPHK1 H2AC14 GATA3 H2BC12L H2BC21 TBP H2BU1 GNAI3 H2AC8 NRIP1 CARM1 H2AC6 H2AC7 GNAI1 GNAI2 H2BC17 H2BC12 FOXO3 H2BC13 ELK1 H2BC14 GNG3 UHMK1 H2AJ CREB1 H2BC15 GNG2 BCL2 H2BC11 GNG5 GNG4 GNG7 GNG8 H2AZ1 H2BC9 H2AZ2 PRKCZ H4C9 H2BC8 H2BC5 NCOA1 H2BC3 H2BC1 NCOA3 H2AC20 ZDHHC21 H3C8 CDKN1B SMC3 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.2 Scavenging by Class B Receptors APOA1 SAA1 CD36 SSC5D APOB TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 80%110312 Translesion synthesis by REV1 RPA3 RPS27A REV1 MAD2L2 REV3L UBA52 PCNA RPA1 RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.1 Nuclear events mediated by NFE2L2 PSMD8 PSMD9 PSMD6 NFE2L2 PSMD7 PSMD4 PSMD5 GSTA1 PSMD2 HMOX1 PSMD3 PSMD1 SQSTM1 CREBBP NOTCH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 EP300 PSME1 PSME2 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYC BACH1 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 GCLC PSMB3 PSMB1 IDH1 PSMF1 BTRC GCLM SRXN1 PSMB8 PSMB9 ME1 SEM1 CDKN2A PSMC5 PSMC6 SKP1 PSMC3 G6PD PSMC4 PSMC1 PSMC2 TALDO1 PGD ATF4 TKT GSTA3 SLC7A11 PRDX1 TXNRD1 UBA52 CUL1 UBB UBC RPS27A MAFG MAFK GSK3B RBX1 NQO1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 80%5654227 Phospholipase C-mediated cascade; FGFR3 PLCG1 FGF1 FGF16 FGF2 FGF18 FGF4 FGF9 FGF20 FGF23 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 80%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB RELA IKBKG RIPK1 CHUK MYD88 NFKB1 NKIRAS1 NKIRAS2 RIPK3 NFKBIA NFKB2 ZBP1 TICAM1 TLR3 DHX9 NFKBIB OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.2 Oxidative demethylation of DNA TDG TET2 TET1 TET3 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.2 Aryl hydrocarbon receptor signalling HSP90AB1 AIP ARNT AHR ARNT2 AHRR PTGES3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 80%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism FADS2 ELOVL1 ACOT8 SCP2 ACSL1 ELOVL5 ELOVL2 ELOVL3 HSD17B4 ACAA1 ABCD1 FADS1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 80%936964 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon RPS27A TANK LY96 CD14 TICAM2 UBA52 IKBKE TLR4 TICAM1 PTPN11 TBK1 UBB IRF3 TRAF3 IRF7 UBC CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 80%983169 Class I MHC mediated antigen processing & presentation FBXO2 HERC2 ATG14 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 NEDD4L SEC13 UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 CDC34 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 UBE2V1 FBXL7 RNF220 TAP2 DET1 LRSAM1 TAP1 TRIM9 ARIH2 RNF144B GAN RNF138 RNF130 HUWE1 KLHL2 WWP1 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 RLIM TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FCGR1BP FBXO27 LTN1 RNF19B UBE2N VHL UBE3A UBE3B FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 FBXO17 UBE4A B2M FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 SOCS3 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F KLHL25 SMURF2 SMURF1 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO32 FBXO30 FBXO31 KLHL20 UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 BLMH UBE2M TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 TRIM69 HLA-H UNKL HLA-B TRIM63 DTX3L HLA-C PDIA3 PJA2 HLA-A PJA1 HLA-F TRAF7 HLA-G THOP1 HLA-E TRIM50 RNF34 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 ELOB RNF7 RNF4 ELOC ASB17 RCHY1 ASB18 HSPA5 FBXL22 ASB15 MKRN1 FBXL21P SEC61G ITCH ASB16 SEC61B FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 NEDD4 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 CUL3 TRIM32 ASB3 ASB1 CUL2 LY96 CD14 MIB2 KBTBD7 S100A1 MYD88 BTRC TIRAP TLR1 TLR6 TLR4 TLR2 SKP1 FBXW11 STUB1 UBE2D3 UBE2L6 HMGB1 HERC5 TRIM4 UBA52 CUL1 UBB UBC RPS27A UBA7 UBE2K RBX1 ANAPC10 LRRC41 ANAPC11 IKBKB PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SIAH2 IKBKG SKP2 SIAH1 CHUK ANAPC7 PSMA5 UBE2C PSMA6 PSMA3 UBE2E1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 SEC22B PSMB10 PSMA8 SEC23A PSMB6 PSMB7 STX4 PSMB4 PSMB5 PSMB2 PSMB3 CALR PSMB1 PSMF1 FCGR1A PSMB8 PSMB9 SEC24B SEC24A SEM1 ERAP2 PSMC5 ERAP1 PSMC6 PSMC3 PSMC4 SEC24D PSMC1 PSMC2 SEC24C NCF1 NCF2 SNAP23 NCF4 MYLIP SEC31A PRKN CYBB ITGB5 SAR1B CYBA VAMP3 PIK3C3 CDC20 BECN1 RBBP6 BTK CTSV PIK3R4 CTSS S100A9 CTSL S100A8 UBA6 FBXO4 UBE2Z UBE2L3 FBXO6 UBE2Q2 UBE2H FBXW4 UBE2B SH3RF1 FBXW5 FBXW10 UBE2E3 UBE2G1 FBXW7 FBXW9 UBE2A UBE2G2 FBXW2 CD207 UBE2W ITGAV UBE2R2 UBA1 FBXL3 FBXL5 SEC61A2 SEC61A1 FGB FGA FGG CANX CD36 TAPBP MRC2 LRR1 CCNF KEAP1 CBLB DCAF1 MRC1 HERC4 HERC3 RNF115 RNF114 HERC1 TRIM21 UBE2D2 FBXO7 RNF111 UBE2D1 HERC6 FBXO9 WSB1 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190374.2 FGFR1c and Klotho ligand binding and activation FGF23 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 80%2500257 Resolution of Sister Chromatid Cohesion INCENP KIF2A SEC13 NUP133 KIF2C KIF2B SMC1A CENPE CENPF TAOK1 NUP160 PPP2CA PPP2CB NUP85 RAD21 PPP1CC NUP43 RANBP2 AURKB BUB1 CLASP2 CLIP1 RPS27 MAD1L1 STAG1 STAG2 NUP37 NDC80 CDCA5 PDS5B SPDL1 PDS5A WAPL RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C ZW10 DSN1 RCC2 ZWINT AHCTF1 XPO1 NDEL1 PPP2R1A PPP2R5D PPP2R1B MIS12 DYNLL1 CKAP5 DYNC1I1 MAPRE1 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L CCNB2 ZWILCH DYNC1LI1 CCNB1 DYNC1LI2 ITGB3BP KIF18A CENPA CENPC KNTC1 CDCA8 CENPT CENPU SGO1 CLASP1 SGO2 SKA1 SKA2 DYNC1H1 NDE1 PLK1 PMF1 CENPH CENPI CDK1 CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 NUDC DYNLL2 SMC3 DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.2 Diseases of the neuronal system RBP4 NAPEPLD OPN1LW RDH5 RBP1 OPN1SW OPN1MW RDH12 LRAT STRA6 TTR ABCA4 RLBP1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 80%419408 Lysosphingolipid and LPA receptors S1PR3 S1PR2 S1PR5 S1PR4 LPAR1 LPAR2 LPAR3 PLPPR1 PLPPR2 LPAR5 PLPPR3 PLPPR4 PLPPR5 S1PR1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.2 p53-Independent G1 S DNA damage checkpoint PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 CHEK2 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 UBB UBC RPS27A CHEK1 CDC25A ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 80%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC11 FZR1 CCND3 CDC23 CCND2 CCND1 CDC26 CDC27 E2F1 E2F2 E2F3 SKP2 ANAPC7 UBE2C UBE2E1 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RB1 CDKN1C CDKN1A ANAPC15 UBE2D1 CDKN1B ANAPC16 ANAPC10 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.1 Erythrocytes take up oxygen and release carbon dioxide RHAG SLC4A1 AQP1 CA1 CA2 CA4 HBB HBA2 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.2 Drug resistance of FLT3 mutants FLT3 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 80%165158 Activation of PKB AKT2 TRIB3 PDPK1 THEM4 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.2 Signaling by ALK in cancer IRS1 VCL SQSTM1 RNF213 EEF1G STRN EIF2AK3 BIRC6 BCL2A1 BCL11A ZC3HC1 RRBP1 WDCP RPS6 EML4 PPM1B MAPK1 MAPK3 GRB2 TPR RANBP2 TPM4 TPM3 CEBPB SKP1 ATIC PPFIBP1 KIF5B LMO7 CLTC DCTN1 KLC1 PIK3R1 SEC31A PIK3CA GCC2 CARS1 PLCG1 JUNB FRS2 CUL1 FRS3 TFG NPM1 STAT3 PRKAR1A MSN MYH9 HIP1 STAT5A ALK RBX1 FN1 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 80%5688354 Defective pro-SFTPC causes SMDP2 and RDS SFTPC NEDDYLATION%REACTOME DATABASE ID RELEASE 80%8951664 Neddylation FBXO2 NEDD8 FBXL8 FBXL4 FBXL7 GAN KLHL2 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 MUL1 KLHL5 NPLOC4 KBTBD8 SPSB4 FBXO27 UBXN7 VHL UFD1 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 KLHL42 CUL7 CUL5 KLHL11 KLHL13 FBXO44 FBXO41 SOCS3 FBXO40 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO32 FBXO30 FBXO31 KLHL20 UBA3 UBE2M KBTBD13 ASB13 ASB14 HIF3A ASB11 ASB12 ELOB RNF7 ELOC ASB17 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 FBXL19 DCAF13 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 CUL3 ASB3 ASB1 CUL2 KBTBD7 BTRC SKP1 FBXW11 WDR5 UBE2D3 COPS7B COPS7A HIF1A UBA52 COPS3 COPS6 COPS5 COPS8 CUL1 RBBP5 UBB UBC RPS27A DDB2 CUL4A DDB1 CUL4B RBX1 LRRC41 PSMD8 PSMD9 PSMD6 NFE2L2 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 GPS1 PSMD1 SQSTM1 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 SOCS2 PSME1 SOCS6 PSME2 SOCS5 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 COP1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CISH DDA1 SPSB3 CCDC8 NAE1 COMMD9 COPS4 COMMD10 COPS2 FEM1C FEM1A FEM1B VCP COMMD8 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 ERCC8 DCAF8 DCAF5 DCAF4 DCAF6 BIRC5 WSB2 CUL9 WDTC1 CCDC22 COMMD3 TULP4 DCAF16 DCAF17 DCAF10 DCAF11 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 PUM2 ANKRD9 DCAF7 FBXO4 FBXO6 UBD FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 UCHL3 FBXW2 NEURL2 FBXL3 FBXL5 SENP8 EPAS1 DTL RBBP7 LRR1 CCNF KEAP1 CAND1 UBE2D2 FBXO7 UBE2D1 FBXO9 WSB1 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 80%6807505 RNA polymerase II transcribes snRNA genes CCNT2 CCNT1 GTF2F1 GTF2F2 POU2F1 INTS1 GTF2B INTS3 GTF2E1 INTS2 CDK9 PHAX GTF2E2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 SP1 INTS14 INTS10 GTF2A1 GTF2A2 ICE1 ICE2 TAF9 SSU72 NABP2 ZC3H8 TAF13 NABP1 TAF11 TBP TAF8 TAF6 TAF5 CCNK POLR2A POLR2B POLR2C POLR2D RPRD2 POLR2E POLR2F POLR2G POLR2H POLR2I SNAPC5 POLR2J ELL2 SNAPC1 POLR2K ELL3 CDK7 SNAPC2 POLR2L PCF11 SNAPC3 SNAPC4 ZNF143 RPAP2 SUPT4H1 NCBP1 NCBP2 SUPT5H RPRD1B ELL SRRT RPRD1A POU2F2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 80%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR ELF1 CBFB IL3 RUNX1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.1 Biosynthesis of protectins ALOX15 CYP1A1 LTA4H CYP1A2 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.4 Fanconi Anemia Pathway UBA52 FAAP100 FAAP24 FAAP20 DCLRE1B DCLRE1A FANCD2 UBB FANCM WDR48 FANCL USP1 FANCA RPA2 UBC FANCB FANCE FANCG RPS27A FANCF RPA3 MUS81 EME1 EME2 ATRIP FAN1 POLN UBE2T FANCI SLX1B CENPX SLX4 FANCC ATR ERCC4 ERCC1 RPA1 CENPS DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 80%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.3 Cyclin E associated events during G1 S transition PSMD8 PSMD9 PSMD6 PSMD7 CCND1 PSMD4 PSMD5 PSMD2 PSMD3 E2F1 PSMD1 AKT3 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 TFDP1 PSMA1 CCNE2 PSMA2 AKT2 TFDP2 PSME3 PSME1 CDK4 AKT1 CCNE1 PSME2 CABLES1 PSMD10 CDK2 WEE1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYC PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 LIN54 PSMB9 SEM1 LIN52 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 LIN37 PSMC2 LIN9 PTK6 RBL2 CCNH CKS1B MAX E2F4 E2F5 CCNA2 CCNA1 UBA52 CUL1 UBB RBBP4 UBC CDK7 RPS27A MNAT1 CDC25A RB1 CDKN1A CDKN1B MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.3 MAP kinase activation IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 MAPK3 PPP2R1A DUSP4 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 MAP2K3 DUSP7 UBE2N MAPK7 TAB3 PPP2R1B TAB2 SKP1 TAB1 FBXW11 MAPK11 TRAF6 UBA52 CUL1 ELK1 CREB1 UBB MAP2K1 UBC TNIP2 MAP3K8 IRAK2 RPS27A ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 80%8983432 Interleukin-15 signaling JAK1 STAT3 GRB2 SOS2 SHC1 GAB2 IL2RG IL15RA SOS1 STAT5A STAT5B IL2RB IL15 JAK3 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 80%912694 Regulation of IFNA IFNB signaling IFNA6 IFNA10 JAK1 IFNA2 PTPN6 IFNA8 TYK2 PTPN1 IFNA21 IFNB1 IFNA13 SOCS3 IFNA14 IFNA16 SOCS1 IFNA17 IFNAR1 PTPN11 IFNA5 USP18 IFNA4 STAT2 IFNA7 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 80%5654708 Downstream signaling of activated FGFR3 FGF16 GAB1 FGF18 PIK3R1 NRAS PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF4 FGF9 FGF20 FGF23 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 80%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PLXNA1 TLN1 FES FYN PIP5K1C RAC1 PLXNA2 RND1 NRP1 PLXNA4 PLXNA3 SEMA3A FARP2 RRAS DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.5 Detoxification of Reactive Oxygen Species CCS PRDX2 PRDX1 TXNRD1 P4HB CYBB CYBA ERO1A ATP7A AQP8 NUDT2 GSTP1 TXN2 PRDX6 PRDX3 SOD2 NOX4 SOD1 NOX5 CAT CYCS ATOX1 GPX1 GPX3 GPX6 GPX5 GPX8 NCF1 GPX7 NCF2 GPX2 NCF4 TXNRD2 SOD3 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 80%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models YWHAE GOLGA2 CAPN2 CDK5R1 CDC25B CAPN1 PRDX2 CAST PRDX1 SOD2 BCL2L11 CDC25A LMNB1 CDC25C FASLG FOXO3 JUN CAPNS1 APP CDK5 CAPNS2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-HSA-380259.1 Loss of Nlp from mitotic centrosomes CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.1 Plasma lipoprotein assembly PRKACG PRKACB APOA2 APOC3 APOA1 APOA4 APOC2 ZDHHC8 P4HB PRKACA MTTP SAR1B ABCA1 APOC4 APOC1 APOE APOB A2M RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 80%111457 Release of apoptotic factors from the mitochondria CYCS BAK1 DIABLO GSDME GSDMD BAX ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.2 Zinc influx into cells by the SLC39 gene family SLC39A6 SLC39A10 SLC39A5 SLC39A8 SLC39A14 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.3 Signaling by NOTCH1 in Cancer HEY1 HEY2 HES5 CREBBP HEYL NOTCH1 MAML2 HDAC10 MAML1 HDAC11 HDAC2 RBPJ HDAC8 KAT2B KAT2A SNW1 EP300 HDAC9 HES1 MAML3 MAMLD1 HDAC6 HDAC7 MYC HDAC4 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SKP1 HDAC5 CCNC NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X UBA52 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 ADAM17 PSEN1 RBX1 JAG1 NCSTN SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 80%8853336 Signaling by plasma membrane FGFR1 fusions BAG4 ERLIN2 FGFR1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.2 Dual incision in TC-NER TCEA1 ZNF830 PCNA POLD3 POLD4 POLD1 POLD2 EP300 POLK POLE RFC5 ISY1 RFC3 USP7 RFC4 HMGN1 RFC1 RFC2 RPA2 POLE4 RPA3 POLE2 UVSSA POLE3 RPA1 CCNH UBA52 AQR PPIE POLR2A POLR2B POLR2C POLR2D UBB POLR2E POLR2F ERCC8 POLR2G POLR2H UBC POLR2I POLR2J PRPF19 POLR2K CDK7 RPS27A POLR2L MNAT1 XPA GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CUL4A DDB1 ERCC3 ERCC4 ERCC1 ERCC2 ERCC5 CUL4B XAB2 RBX1 ERCC6 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 80%73942 DNA Damage Reversal ALKBH5 ASCC1 ASCC2 ASCC3 MGMT ALKBH2 FTO ALKBH3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 80%71387 Carbohydrate metabolism ABCC5 NUP62 HPSE2 NUP214 SLC35B3 XYLT2 NDC1 AGL SLC35B2 XYLT1 HS6ST1 SEC13 HS6ST2 NUP210 SGSH HS2ST1 NUP133 HS6ST3 SLC35D2 NDST2 NDST1 GPI PYGB NAGLU NDST4 NDST3 CHPF NUP93 IDS CHP1 CSGALNACT1 GUSB CSGALNACT2 HS3ST3B1 GLCE CEMIP CHST11 NUP50 B4GALT7 HS3ST3A1 CHST12 NUP54 IDUA DSEL NUP205 CHST15 B3GAT3 POM121 CHST13 B3GAT2 UST B3GAT1 B4GALT2 HS3ST5 AAAS CALM1 B4GALT3 HS3ST6 HYAL1 NUP160 HS3ST4 HYAL2 HS3ST1 HYAL3 HS3ST2 EXT1 DSE POM121C EXT2 CHST7 HPSE CHPF2 NUP42 NUP85 B3GNT7 B3GNT4 B3GNT3 CHST1 TPR NUP88 B3GNT2 HMMR B4GALT6 NUP43 CHST5 RAE1 RANBP2 B4GALT4 CHST2 B4GALT5 HAS1 HAS3 HAS2 NUP155 CHSY3 LYVE1 NUP153 PFKL NUP35 NUP37 CHST3 MANBA EPM2A GBE1 GAA G6PC1 GYS2 GYS1 G6PC3 PPP1R3C NHLRC1 ALDOC PRKACG GYG2 PRKACB ALDOA SLC37A4 GYG1 GLYCTK MAN2B1 SLC9A1 RHCE RHD ALDH1A1 PPP2R1A SLC26A2 PRKACA SLC26A1 HK3 GOT2 CHST14 CHSY1 SLC25A10 UBA52 UBB UBC GNS RPS27A TKFC SLC25A1 SORD AKR1B1 PYGM PHKB PHKA1 PGAM1 PHKA2 PGM2L1 PHKG1 PHKG2 KHK PFKFB2 PFKFB1 PFKFB4 PFKFB3 SLC2A1 PPP2CA PPP2CB PGK1 ENO1 ENO2 ENO3 PRPS2 PGK2 PRPS1 PCK2 ALDOB G6PD PAPSS1 SLC37A1 DCXR RPEL1 TPI1 RPE TALDO1 MDH1 PGAM2 PGD DERA G6PC2 HK1 GAPDH RPIA SHPK SLC25A11 PGM2 FBP1 PGLS FBP2 PRPS1L1 TKT RBKS AKR1A1 PAPSS2 UGP2 GCKR SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 PGM1 GPC2 GPC5 CSPG4 GPC4 AGRN GPC6 HSPG2 BCAN HEXB HEXA GALE ST3GAL6 ST6GALNAC6 B4GAT1 FUT10 FUT11 B3GALT4 B3GALT5 FUT2 FUT1 ABO FUT4 FUT3 FUT6 PGP FUT5 FUT7 FUT9 ADPGK B3GALT2 SLC25A12 B3GALT1 B4GALNT2 BPGM SLC25A13 DCN GAPDHS MAN2B2 MAN2C1 GOT1 PC CD44 HK2 PPP2R5D ARSB CRYL1 PPP2R1B XYLB ACAN GLB1L GLB1 STAB2 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 PCK1 CHST6 LUM OGN OMD KERA PRELP FMOD PFKM B4GALT1 PFKP MDH2 NUP107 LALBA GALT NUP188 GNPDA1 GNPDA2 GCK GALK1 HEME DEGRADATION%REACTOME%R-HSA-189483.3 Heme degradation FABP1 GSTA1 HMOX1 ALB UGT1A4 SLCO1B1 HMOX2 SLCO1B3 ABCC1 UGT1A1 ABCG2 ABCC2 BLVRB BLVRA APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 80%174048 APC C:Cdc20 mediated degradation of Cyclin B ANAPC11 RPS27A CDC23 CDC26 CDC20 CDC27 UBA52 ANAPC7 UBE2C UBE2E1 CDK1 UBE2S CDC16 CCNB1 ANAPC4 UBB ANAPC5 ANAPC15 UBE2D1 ANAPC1 ANAPC2 ANAPC16 ANAPC10 UBC ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.4 ER to Golgi Anterograde Transport NSF COPZ1 ARF5 SPTBN2 SEC13 GRIA1 USO1 LMAN2 STX5 TRAPPC10 ARCN1 SPTA1 CAPZA1 CAPZA2 TRAPPC2 SEC16B SEC22B TRAPPC3 SEC23A TRAPPC4 SEC16A TRAPPC5 TRAPPC9 SEC24B SEC24A CNIH1 CNIH2 CNIH3 MCFD2 SEC24D SEC24C PPP6R1 BET1L ARFGAP1 SEC22A ARF3 SEC22C RAB1A RAB1B PPP6C PPP6R3 TRAPPC1 SEC31A FOLR1 BET1 KDELR1 COL7A1 SAR1B TMED2 COG8 COG7 COG6 LMAN1L COG5 COG4 CTSZ ARFGAP3 COG3 COG2 COG1 ARFGAP2 PREB ANKRD28 KDELR2 KDELR3 LMAN1 LMAN2L CTSC MIA2 TMED3 YKT6 TMED7 TMED9 NAPB STX17 NAPG AREG SEC23IP COPG2 COPG1 TGFA CD59 SCFD1 CD55 SPTBN1 TRAPPC2L TBC1D20 CAPZA3 COPB2 COPA TMED10 COPB1 SPTAN1 ACTR1A SPTB TMEM115 COPE ANK1 TRAPPC6A CSNK1D TRAPPC6B GOLGA2 GORASP1 DYNLL1 ARF4 GOSR2 ANK2 GOSR1 DYNC1I1 DCTN6 ANK3 DCTN5 DCTN1 ACTR10 DCTN4 F5 NAPA DYNC1I2 F8 DCTN2 DCTN3 ARF1 DYNC1LI1 MIA3 TFG DYNC1LI2 GOLGB1 DYNC1H1 GBF1 SERPINA1 INS CAPZB SPTBN4 SPTBN5 COPZ2 DYNLL2 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.2 LGK974 inhibits PORCN PORCN RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.3 RAF-independent MAPK1 3 activation JAK1 MAPK1 PEA15 MAPK3 TYK2 DUSP16 IL6 DUSP10 DUSP4 IL6R DUSP8 DUSP9 DUSP6 DUSP7 CDK1 PTPN11 DUSP5 DUSP2 MAP2K2 DUSP1 MAP2K1 JAK2 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 80%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 TRYPTOPHAN CATABOLISM%REACTOME%R-HSA-71240.2 Tryptophan catabolism KYAT3 SLC7A5 HAAO KMO KYAT1 AADAT AFMID ACMSD SLC3A2 TDO2 KYNU IDO2 IDO1 SLC36A4 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 80%9013973 TICAM1-dependent activation of IRF3 IRF7 IKBKE RPS27A TICAM1 TANK TLR3 TBK1 UBB IRF3 UBA52 TRAF3 IRF7 UBC DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.2 Defective MPI causes CDG-1b MPI PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 80%8852135 Protein ubiquitination LEO1 PRKDC PAF1 UBE2J2 UBE2C CDC34 UBE2E1 PCNA RNF152 SHPRH UBE2S PEX2 UBA6 UBE2Z RNF40 UBE2L3 RNF144A UBE2Q2 SELENOS USP7 WAC DERL1 UBE2H USP5 TMEM129 HLTF UBE2B USP9X PEX10 UBE2E3 BCL10 PEX12 UBE2G1 PEX14 UBE2A RNF181 UBE2G2 UCHL3 UBE2W RRAGA UBE2R2 UBE2T OTULIN UBA1 UBE2N WDR61 UBE2D3 UBE2V2 UBA52 VCP H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBB UBC RAD18 H2BC9 RPS27A H2BC8 H2BC5 H2BC3 H2BC1 HLA-B RNF20 HLA-A UBE2K CDC73 UBE2D2 CTR9 UBE2D1 RTF1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 80%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB RELA IKBKG RIPK1 CHUK MYD88 NFKB1 NKIRAS1 NKIRAS2 RIPK3 NFKBIA NFKB2 ZBP1 TICAM1 NLRP4 TLR3 DTX4 DHX9 NFKBIB TBK1 IRF3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 80%201722 Formation of the beta-catenin:TCF transactivating complex LEO1 BCL9L BCL9 CREBBP KMT2D TLE4 H3C15 TLE2 TLE1 EP300 TCF7L2 TCF7L1 MYC TCF7 LEF1 CTNNB1 RUNX3 MEN1 TLE3 KAT5 HDAC1 AXIN2 H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 RUVBL1 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 TERT H2BC13 H2BC14 RBBP5 H2AJ H2BC15 H2BC11 TRRAP H2AZ1 H2BC9 SMARCA4 H2AZ2 H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 CDC73 H3C8 ASH2L PYGO1 PYGO2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 80%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism MMUT MMACHC LRP2 MMADHC CBLIF CTRB2 CTRB1 LDLRAP1 CUBN TCN1 AMN TCN2 CD320 ABCD4 ABCC1 PRSS1 MTRR MMAA LMBRD1 MMAB MTR PRSS3 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.1 Defective F9 secretion F9 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.3 Clathrin-mediated endocytosis VAMP4 SH3GL2 ARF6 GPS1 NEDD8 SH3KBP1 SNX18 KIAA0319 AVP TOR1A HGS TOR1B DAB2 AAK1 RAB5B RAB5C SGIP1 TFRC ARFGAP1 DVL2 LRP2 CLTC ARPC4 FCHO1 ARPC5 CLTA COPS4 FCHO2 UBQLN1 ARPC2 EGF ARPC3 LDLRAP1 UBQLN2 COPS2 NECAP2 CBL SYT11 EGFR OCRL BTC PICALM LDLR AGFG1 ACTR3 SYNJ2 HBEGF EREG ACTR2 CD3G VAMP3 CHRM2 CD3D ADRB2 SYT1 SNAP91 DNM1 DNM2 DNM3 HIP1 PIK3C2A CLTB APOB CFTR AREG EPS15 PIP5K1C SH3GL3 TGFA SCARB2 EPGN CLTCL1 STAM SH3GL1 AMPH SYNJ1 WASL GRK3 PACSIN2 PACSIN3 GRK2 PACSIN1 SYT2 CD4 HSPA8 SYT9 CTTN SYT8 SLC2A8 EPN1 EPN2 AVPR2 ITSN2 ITSN1 COPS7B COPS7A FNBP1L TGOLN2 UBA52 COPS3 REPS2 COPS6 COPS5 GAK REPS1 TRIP10 COPS8 DNAJC6 FNBP1 TF SNX9 UBB UBC M6PR GAPVD1 BIN1 IGF2R RPS27A HIP1R AGTR1 IL7R RAB5A NECAP1 STAM2 AP2S1 AP2A1 VAMP7 AP2B1 AP2A2 AP2M1 WNT5A VAMP2 ARRB1 STON1 ARRB2 ARPC1A STON2 SLC18A3 FZD4 TACR1 EPS15L1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.1 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 CLTC CLTA AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 WNT5A ROR1 ROR2 FZD2 FZD5 CLTB ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9026527.1 Activated NTRK2 signals through PLCG1 BDNF NTRK2 PLCG1 NTF4 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 80%168249 Innate Immune System AGA METTL7A RAF1 AOC1 VCL AGL CARD9 ERP44 HSPA1B HSPA1A GHDC ATP8A1 EPX PYCARD CLEC5A DEFB119 DEFB118 DEFB117 DEFB116 GUSB CD180 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 CLEC4A CLEC4C CLEC4D CLEC4E BRI3 HPSE HVCN1 VTN CLEC7A SLC15A4 ATP8B4 CLEC6A TREM1 KCNAB2 ITLN1 FCGR3B PFKL IMPDH1 IMPDH2 MNDA FOLR3 PLAUR B2M MUCL1 SLC11A1 CHIT1 PLPP5 PLPP4 MGST1 C4B_2 SIGLEC16 SIGLEC15 PTPRN2 SIGLEC14 STK11IP GDI2 GLIPR1 MANBA NME2 CEACAM3 CEACAM1 CEACAM6 ALDOC CEACAM8 ALDOA DNASE1L1 LILRA3 BST1 CXCR1 CXCR2 LILRB2 LILRB3 SIRPA CD300A ELMO1 CD300E DEFB130A ATF2 AHCYL1 DEFB130B DEFB131A C5AR2 C5AR1 PRKCE DPP7 KLRC2 HSPA6 DNAJC13 MAN2B1 KLRD1 CRISP3 SLC2A3 CXCL1 SLC2A5 HTN1 HTN3 HEBP2 NAPRT FRK CMTM6 MYD88 TRPM2 IRAK4 LRRFIP1 VNN1 PDZD11 TICAM1 TLR3 CNN2 GNS ANXA2 MIF PPIA MEF2A MEF2C RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 SIGIRR CAB39 MAP2K6 GSDMD TOLLIP RIPK2 IRAK3 IL1B NOD1 NOD2 ALOX5 PTPN4 LAMTOR2 LAMTOR1 LAMTOR3 NCKAP1 CYFIP1 NCF1 NCF2 SNAP23 NCF4 BRK1 STBD1 CYBB CYBA VAV2 RAB7A PIK3R2 NCKAP1L WASF1 WASF2 BAIAP2 ABI2 ABI1 PKP1 DSC1 S100A7A LCN2 S100A9 S100A8 LTF S100A7 PTPRC ITGAV DUSP4 DUSP3 PPP2R5D VRK3 DUSP6 DUSP7 MAPK7 PPP2R1B MYO10 PROS1 PRCP CD177 FGB FGA FGG F2 SERPING1 PRTN3 PPP3CB CD36 CAP1 TYROBP EEF1A1 EEF2 MAPK12 MAPK13 POLR2E POLR2F POLR2H POLR2K POLR2L NOS1 FGR PECAM1 ITPR1 ITPR2 ITPR3 NOS2 NOS3 MAPK14 P2RX7 P2RX1 PTPN6 IRAK1 PELI3 PELI2 PELI1 KPNB1 PI3 TREM2 ABL1 NFASC KRT1 HBB RBSN DOCK2 DOCK1 CAPZA1 CAPZA2 CTNNB1 CHRNB4 NPC2 SDCBP IRAK2 RHOA MYH9 DNM1 DNM2 HEXB DNM3 GM2A ARSA ASAH1 GPR84 ALDH3B1 NEU1 ORMDL3 PSAP ARSB CTSA VAPA GLB1 DEGS1 PRKCSH MAGT1 GOLGA7 DDOST B4GALT1 ATP6V1A TCIRG1 ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 ATP6V1F TRIM21 ATP6V1C2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATG7 LRRC7 CALM1 SLCO4C1 HUWE1 CPNE1 CPNE3 DGAT1 ROCK1 CSNK2B MUC13 DSP PLD4 PLA2G6 PLD1 PLD3 PLD2 CKAP4 UBR4 DSG1 SOCS1 GAA SLC44A2 LPCAT1 GYG1 UBA3 UBE2M AGPAT2 CASP9 PLA2G2A ZBP1 NLRP4 DTX4 GRAP2 MAP2K4 PLCG2 MAP2K7 JUN VAV3 SYK FOS LCP2 MAPK9 MAPK8 MAPK10 TRIM32 UNC93B1 PPP2R1A LY96 CD14 S100A1 TIRAP BTRC PRKACA TLR1 TLR10 CEP290 TLR6 TLR5 TLR4 TLR2 SKP1 HSP90AA1 APAF1 FBXW11 TUBB CASP1 CASP2 NLRC4 CYFIP2 DYNLL1 WIPF1 WIPF2 WIPF3 UBA52 PRKCD CUL1 FPR1 DYNC1LI1 FPR2 UBB UBC RPS27A IQGAP1 IQGAP2 DYNC1H1 HMOX2 TUBB4B JUP ARHGAP9 ARPC1B ARPC1A PTPN11 BIRC2 BIRC3 IKBKB PSMD8 PSMD9 ATF1 PSMD6 PGLYRP4 PSMD7 PGLYRP3 PSMD4 PGLYRP2 PSMD5 GMFG PSMD2 PSMD3 C3AR1 PSMD1 PGLYRP1 IKBKG MAP3K7 MCEMP1 CHUK TXNIP LTA4H PSMA5 PSMA6 PSMA3 PSMA4 FUCA1 PSMA1 FUCA2 PSMA2 PSME3 PSME4 PSME1 PSME2 CARD11 PSMD10 PSMB11 LGMN PSMD12 SIGLEC9 PSMD11 PANX1 PSMD14 OLR1 PSMD13 BCL10 PSMA7 PAFAH1B2 RELA MALT1 PSMB10 GSTP1 PSMA8 PTAFR PSMB6 PSMB7 PSMB4 STK10 PSMB5 PSMB2 CFL1 PSMB3 PSMB1 PSMF1 YPEL5 NFKB1 PSMB8 PSMB9 NFKBIA SIGLEC5 SEM1 PSMC5 PSMC6 CRCP PSMC3 PSMC4 APEH PSMC1 TOM1 PSMC2 IST1 NFKBIB TBK1 ATP11B ATP11A STING1 STAT6 CNPY3 ACLY SLC27A2 ARL8A FTL REG3A ARPC4 REG3G ARPC5 HSP90B1 TXNDC5 ARPC2 ARPC3 PIK3R1 LY86 NF2 NRAS NIT2 SNAP25 PIK3CA ITGAM PLCG1 KIR3DS1 SOS1 HRAS LEAP2 ITGB2 ITGAL NCK1 ALAD ACTR3 ITGAX ACTR2 ACP3 SNAP29 PGM1 MBL2 RNASET2 CAPN1 PIK3C3 PRSS2 TNFRSF1B MUC5AC TMBIM1 BPI TRIM56 ADAM10 CANT1 C1S C1R ADAM8 WASF3 TSPAN14 MYO1C PSEN1 NCSTN ICAM2 ICAM3 ELANE BTK C4A LGALS3 CTSV ANPEP PIK3R4 CTSS MMP25 C6orf120 SLPI DSN1 CTSL CRISPLD2 CTSK TIMP2 CTSG TMEM63A DHX9 PTK2 MMTAG2 SYNGR1 CTSD CTSB FAF2 WASL RAB27A MYO5A NBEAL2 MMP8 PPBP MMP9 BST2 RAC2 SPTAN1 RHOG RHOF CD44 C8B C8A PPP3CA ACTR1B C8G MUC12 FCER1A MUC15 CAMP FCER1G RAP2C RAP2B WAS RELB GCA CFHR2 CFHR1 CFHR4 CFHR3 SEMG1 CFHR5 ACTR10 MYO9B SRP14 PLAU ENPP4 RAB9B IRAG2 MUC3A MUC3B PPIE ADGRG3 MGAM ACTG1 MUC16 MUC17 MUC19 GGH ADA2 IGF2R MUC20 ARHGAP45 MUC21 MS4A3 TNFAIP6 ELMO2 ADGRE5 ADGRE3 ATP6AP2 CAT CHI3L1 MS4A2 RETN NCKIPSD CAND1 MUC5B GALNS TEC PTX3 SUGT1 CDA UBE2D2 FRMPD3 IGHV3-23 CLEC10A UBE2D1 IGLV IGLV2-8 IGKV1-16 PRSS3 IGKV1-17 ARMC8 IGKV1-12 IGHV3-7 CFH IGHV3-9 PRKDC V2-11 CFI IGHV3-30 CFP PLAC8 V3-4 DIAPH1 HMOX1 V3-3 V2-17 V3-2 IGHV3-33 NFATC3 V2-15 NFATC2 IGKV1D-39 NFATC1 V2-19 TCN1 IGKV1D-33 GPI CDC34 PYGB GNLY IGKV2D-28 IGKV4-1 AHSG IGHV7-81 PRKCQ UBE2V1 PLEKHO2 V1-11 IGKV2D-30 GRN V1-16 V1-13 IGHV4-59 IGHV1-69 GSN RASGRP2 RASGRP1 RASGRP4 IGLV2-11 MRE11 IGLV1-40 RAB3A IGLV1-47 IGLV6-57 IGLV2-14 TMEM179B IGLV1-44 IGKV3-15 RAB3D IGKV3-11 LYN CLU V2-8 DEFB109B IGHG3 V1-20 MOSPD2 RAB44 IGKV2D-40 IGHV3-11 IGHG4 IGHV3-13 IGHG1 IGKV1D-16 IGHG2 LAMP1 IGLV7-43 IGKV1D-12 LAMP2 IGLV1-51 IGLV2-23 STOM UBE2N MAP2K3 TAB3 KCMF1 TAB2 ILF2 TAB1 IGKV3-20 RAB31 RAB37 IGHV4-34 IGHV1-2 LIMK1 IGHV1-46 RAB5B RAB5C IGHV4-39 IGHV CD300LB MAPK11 IGKV2-29 IGKV2-28 IGLC3 RAB6A IGLC1 IGLC2 V1-9 V5-4 AP1M1 V1-7 V5-1 RAB4B TRAPPC1 V1-5 PDPK1 POLR3GL V1-3 MAP3K14 IGKV3D-20 V5-6 BCL2L1 TRAF6 IGHE FCAR IGLV3-19 PSTPIP1 IGKV2-30 LBP IGHV2-70 CR2 IGHV2-5 IGLV3-1 CR1 IGHV3-48 PKM IGLV3-25 DNAJC5 IGLV3-27 CRK IGKC CRP IGKV1-39 FGL2 IGLV3-21 NLRC3 IGKV1-33 TTR V4-6 RAB24 IGHV3-53 V4-2 CPPED1 IGLC7 RAB10 V4-1 POLR3A IGKV5-2 POLR3B IGKV1-5 POLR3C IGLC6 MAP2K1 POLR3D TNIP2 POLR3E PRKACG MAP3K8 RAB18 PRKACB POLR3F POLR3G YES1 POLR3H POLR3K CALML5 FTH1 TBC1D10C HLA-H HLA-B HLA-C HLA-A HLA-E TXK MLEC VAT1 ORM1 ORM2 ITCH CREBBP HCK TLR9 TLR8 TLR7 C1QB CSTB C1QA CST3 EP300 LAIR1 PTGES2 SVIP QPCT C1QC FCN1 FCN2 FCN3 COTL1 COPB1 LPO NLRP3 NLRP1 CD4 TREX1 IDH1 SELL C3 CFD CGAS GZMM CFB HK3 CASP4 HGSNAT DCD MYH2 AIM2 IFNA5 IFNA4 DEFB4B OTUD5 APP COLEC11 IFNA7 PDXK IFNA6 COLEC10 HSP90AB1 CLEC12A UBE2D3 IFNA2 MUC1 TNFAIP3 UBE2L6 MUC2 HMGB1 MUC7 IFNA8 HERC5 IFIH1 CASP8 MUC4 TRIM4 CASP10 NKIRAS1 MUC6 NKIRAS2 TMEM30A C4BPA DHX58 C4BPB TRIM25 IKBKE POLR1C POLR1D TOMM70 IFNA13 IFNA14 RNASE6 IFNA16 RNASE3 DDX58 SCAMP1 IFNA17 RNASE2 TRAF2 FLG2 ATG12 PADI2 SIKE1 RNF125 IRF3 C2 TRAF3 IRF7 C5 TAX1BP1 KLRK1 IFNA10 NLRX1 C6 CYB5R3 UBA7 C7 NLRC5 C9 AGER TANK AZU1 RNF135 LYZ TKFC RNF216 HRNR PCBP2 PIGR S100A12 ECSIT RIPK1 EEA1 ACAA1 FADD ATG5 IFNA21 RIPK3 MAP3K1 ARG1 IFNB1 PGAM1 ISG15 TMC6 S100B NFKB2 SERPINB10 CYLD SERPINB12 MAVS SAA1 PIN1 UBE2K RNASE8 RNASE7 LRG1 HP DEFB1 TICAM2 OLFM4 DNAJC3 MAPKAPK3 MAPKAPK2 CPB2 DEFA6 DEFA4 DEFA5 DEFA3 PTPRB FCGR3A ATP7A PPP2CA NDUFC2 PPP2CB MAPK1 MAPK3 IFI16 TIFA FCGR1A AAMP ATOX1 FCGR2A VPS35L DERA PGM2 BPIFA1 BPIFA2 ALPK1 DEFB103B CDC42 PAK1 LCK ART1 FYN COMMD9 DHX36 RAC1 PAK3 PAK2 VAV1 DEFB104B XRCC6 VCP XRCC5 SURF4 PRG2 PRG3 BPIFB2 BPIFB1 BPIFB4 BPIFB6 CYSTM1 DEFB105B CTSZ CD3G PTPRJ CTSH QSOX1 CD209 CCR6 CD33 CTSC CCR2 CD53 DEFB106B DBNL MME COMMD3 ANO6 LAT2 NCR2 CD47 APOB CD46 CD63 DEFB129 DEFB128 DEFB127 DEFB126 PIK3CB DEFB125 DEFB124 DEFB123 DEFB121 DEFB107B CPN2 GAB2 CPN1 PGRMC1 CREG1 CD59 CD19 CD58 ACTB CD55 DEFB136 DEFB135 DEFB134 DEFB133 DEFB132 DEFB108B DEFB108C CD68 CD81 MPO OSTF1 EPPIN FABP5 CD93 ATAD3B OSCAR DOK3 MASP1 HSPA8 TARM1 DDX3X DDX41 SIRPB1 DYNLT1 CCT2 MVP DEFA1B CHGA PDAP1 S100P ABCA13 ELK1 NHLRC3 UNC13D CREB1 BIN2 A1BG BCL2 MEFV PPP3R1 CRACR2A PRDX4 CCT8 S100A11 KIR2DS2 KIR2DS4 KIR2DS5 PA2G4 PRDX6 AMPD3 APRT CDK13 GSDME SERPINA3 PNP ATP6V1H ITK SERPINA1 AP2A2 RAP1B RAP1A SERPINB3 SERPINB1 NFAM1 SERPINB6 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 80%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 80%73884 Base Excision Repair PARP1 PCNA POLD3 NTHL1 POLD4 POLD1 POLD2 POLE RFC5 RFC3 RFC4 LIG1 RFC1 PARG POLB RFC2 RPA2 APEX1 ADPRS XRCC1 LIG3 POLE4 RPA3 POLE2 POLE3 TDG NEIL3 RPA1 FEN1 H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 H2AC7 MPG H2BC17 H2BC12 H2BC13 PNKP H2BC14 MBD4 H2AJ SMUG1 NEIL2 H2BC15 H2BC11 NEIL1 OGG1 H2AZ1 H2BC9 H2AZ2 PARP2 ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 80%205025 NADE modulates death signalling YWHAE NGFR CASP3 NGF BEX3 CASP2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.3 Transcriptional regulation of white adipocyte differentiation CCND3 HELZ2 ADIPOQ CREBBP ANGPTL4 PPARG MED30 MED31 ADIRF EP300 CDK4 TNF WNT1 RELA FABP4 NCOA2 CHD9 ZNF638 PLIN1 NFKB1 CEBPA TGFB1 CDK8 CEBPB RXRA CCNC KLF5 NCOR2 HDAC3 TGS1 NCOR1 TBL1XR1 TBL1X SMARCD3 CEBPD PPARGC1A CARM1 NR2F2 MED19 MED16 MED1 MED15 MED18 MED8 PCK1 MED17 MED9 MED12 MED4 MED11 EGR2 MED14 KLF4 MED13 MED6 MED10 MED13L LEP MED7 MED27 MED26 MED29 CD36 MED28 SLC2A4 NCOA1 MED23 MED22 MED25 NCOA6 MED24 NCOA3 EBF1 MED21 MED20 SREBF2 PPARA WNT10B CDK19 THRAP3 LPL ZNF467 FAM120B POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 80%426496 Post-transcriptional silencing by small RNAs TNRC6B AGO3 AGO4 AGO1 TNRC6C AGO2 TNRC6A SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-HSA-480985.2 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 80%8939902 Regulation of RUNX2 expression and activity PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SKP2 PSMA5 PSMA6 PSMA3 PSMA4 ESR1 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 MSX2 PSMD10 PSMB11 PSMD12 DLX5 PSMD11 DLX6 PSMD14 PSMD13 HIVEP3 PPARGC1B PSMA7 ESRRA WWP1 PSMB10 BMP2 PSMA8 PSMB6 PSMB7 PSMB4 NKX3-2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 CBFB PSMC4 PSMC1 PSMC2 STUB1 NR3C1 STAT1 UBA52 PPARGC1A CUL1 UBB SMURF1 UBC RPS27A GSK3B RBX1 TWIST1 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.1 Hedgehog 'on' state PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 CSNK1A1 PSMD1 ITCH SHH HHIP PSMA5 BOC PSMA6 IHH PSMA3 PSMA4 GAS1 PSMA1 PSMA2 PSME3 PSME4 PSME1 ULK3 PSME2 DZIP1 EFCAB7 IQCE PSMD10 EVC PSMB11 GAS8 PSMD12 PSMD11 SPOP PSMD14 EVC2 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 CUL3 PSMB7 PSMB4 GRK2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DHH UBA52 SMURF2 UBB SMURF1 UBC RPS27A SMO CDON GPR161 KIF3A PTCH1 ARRB1 ARRB2 GLI1 GLI3 GLI2 CDC73 SUFU RBX1 KIF7 NUMB SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 80%9726840 SHOC2 M1731 mutant abolishes MRAS complex function MRAS ARAF RAF1 PPP1CB PPP1CC SHOC2 YWHAB BRAF INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 80%8981373 Intestinal hexose absorption RSC1A1 SLC2A5 SLC5A1 SLC2A2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 80%450531 Regulation of mRNA stability by proteins that bind AU-rich elements PSMD8 PSMD9 PRKCA PSMD6 PSMD7 PSMD4 NUP214 PSMD5 PSMD2 PSMD3 PSMD1 HSPA1A YWHAB PSMA5 PSMA6 PSMA3 MAPKAPK2 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 AKT1 PSME2 MAPK14 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 ELAVL1 YWHAZ PSMD13 TNFSF13 PSMA7 XPO1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 HSPA8 PSMB8 PSMB9 DIS3 SEM1 EIF4G1 PSMC5 PSMC6 XRN1 PSMC3 DCP2 PSMC4 PSMC1 PARN PSMC2 EXOSC7 EXOSC6 EXOSC5 MAPK11 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 UBA52 DCP1A HSPB1 PRKCD SET UBB UBC ANP32A RPS27A KHSRP ZFP36L1 ZFP36 TNPO1 PABPC1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.2 Toxicity of botulinum toxin type C (botC) SNAP25 STX1A STX1B CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.1 Chylomicron clearance LDLR LIPC LDLRAP1 APOE APOB ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 80%400042 Adrenaline,noradrenaline inhibits insulin secretion GNGT2 ADCY6 ADCY5 ADRA2C ADRA2A GNAI1 GNAI2 CACNA1D CACNA1C CACNA2D2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNB2 CACNB3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 80%4793950 Defective MAN1B1 causes MRT15 MAN1B1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-HSA-69231.8 Cyclin D associated events in G1 RBL2 RBL1 CCNH CKS1B CCND3 E2F4 CCND2 E2F5 CCND1 E2F1 E2F2 E2F3 SKP2 UBA52 CDKN2D CDKN2B CDK6 CDKN2C TFDP1 ABL1 CCNE2 TFDP2 CUL1 CDK4 CCNE1 CDK2 UBB UBC PPP2CA PPP2CB CDK7 RPS27A MNAT1 PPP2R2A LYN PPP2R1A CDKN2A PPP2R1B SKP1 PTK6 RB1 CDKN1C CDKN1A PPP2R3B CDKN1B JAK2 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.2 Defective DOLK causes CDG-1m DOLK DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.2 Diseases of cellular response to stress CDK6 CDKN2A CDK4 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 80%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDKN2A CDK4 PTK6 ACTIVATES STAT3%REACTOME%R-HSA-8849474.1 PTK6 Activates STAT3 SOCS3 STAT3 STAP2 PTK6 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 80%9026519 Activated NTRK2 signals through RAS BDNF NTRK2 SOS1 HRAS NTF4 NRAS DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME%R-HSA-5545483.1 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.2 Glycine degradation GLDC GCSH DLD AMT CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.3 Cilium Assembly C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 B9D1 CEP89 IFT172 KIF17 DYNC2H1 RPGRIP1L IFT88 SMO KIF3A TTC21B TNPO1 ARL13B INPP5E IFT122 PDE6D MKS1 IFT52 IFT57 IFT140 WDR35 WDR19 TRIP11 HDAC6 CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 KIFAP3 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E CCT3 TUBG1 CCT2 DYNLL1 CKAP5 DYNC2I2 ARF4 HAUS2 DYNC2I1 TUBA4A PKD2 TRAF3IP1 PKD1 HAUS1 IFT80 AKAP9 CNGA2 TCP1 IFT81 BBS9 CEP63 DYNC2LI1 CNGA4 MAPRE1 HSPB11 BBS7 BBS5 SFI1 DYNLT2B BBS4 ATAT1 MKKS TTC30B EXOC8 SDCCAG8 TTC30A CEP97 KIF3B IFT20 EXOC7 PAFAH1B1 B9D2 CYS1 IFT22 DYNC1I2 IFT27 SSTR3 DCTN2 LZTFL1 KIF3C DYNLRB2 SSNA1 DYNLRB1 BBS10 DCTN3 TTC26 RP2 DYNLT5 BBS12 DYNLT2 EXOC4 IFT43 EXOC3 EXOC6 IFT46 HAUS8 EXOC5 IFT74 EXOC2 HAUS7 CLUAP1 PRKAR2B CNGB1 CEP70 EXOC1 UNC119B CCT8 ARL6 CEP72 ARL3 CEP192 CCT5 ASAP1 CCT4 MCHR1 PCNT CEP76 RHO NPHP3 CLASP1 RAB11FIP3 CEP78 BBS2 PLK4 BBS1 DYNC1H1 ODF2 RAB3IP NDE1 GBF1 BBIP1 CEP152 PLK1 RAB11A TUBB4B TTC8 TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 DYNLL2 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 80%3560783 Defective B4GALT7 causes EDS, progeroid type GPC2 GPC5 CSPG4 DCN GPC4 AGRN GPC6 HSPG2 BCAN SDC4 NCAN B4GALT7 SDC2 SDC3 BGN VCAN GPC1 GPC3 CSPG5 SDC1 IRS ACTIVATION%REACTOME%R-HSA-74713.2 IRS activation INSR IRS1 IRS2 GRB10 INS REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.1 Regorafenib-resistant KIT mutants KIT CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.1 Chylomicron remodeling GPIHBP1 APOA2 APOC3 APOA1 LPL APOA4 APOA5 APOC2 APOE APOB SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 80%194138 Signaling by VEGF CDH5 PRKCA PRKCB DOCK1 MAPKAPK3 MAPKAPK2 AKT2 MLST8 PXN AKT1 CALM1 MTOR CTNNB1 AAMP PTK2B NCKAP1 CYFIP1 CTNND1 NCF1 ROCK1 NCF2 MAPK11 NCF4 BRK1 CDC42 PAK1 PDPK1 FYN RAC1 PAK3 PAK2 PIK3R1 VAV1 MAPK12 MAPK13 NRAS PIK3CA HSPB1 PLCG1 CRK CYBB HRAS CYBA NCK2 NCK1 VAV2 PRKACG PRKACB RHOA PIK3R2 ROCK2 SHB SH2D2A AXL NCKAP1L WASF3 WASF1 WASF2 ELMO1 CAV1 AHCYL1 BAIAP2 TRIB3 PIK3CB MAPKAP1 ABI2 ITPR1 ABI1 ITPR2 ITPR3 AKT3 SHC2 NOS3 PTK2 RICTOR MAPK14 VAV3 ITGAV RASA1 THEM4 PRR5 PRKACA NRP1 HSP90AA1 BCAR1 CYFIP2 CTNNA1 SPHK1 PRKCD PRKCZ NRP2 ELMO2 JUP ITGB3 FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.1 NOTCH2 Activation and Transmission of Signal to the Nucleus RPS27A CNTN1 APH1A PSENEN APH1B JAG2 NOTCH2 PSEN2 ADAM10 MIB2 UBA52 DLL1 MIB1 DLL4 NEURL1B NEURL1 PSEN1 JAG1 UBB NCSTN MDK UBC NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L PPP2CA RPS4Y1 RPS15A PPP2R2A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 EIF4G1 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UPF2 EIF4A3 CASC3 MAGOH SMG1 NCBP1 SMG9 NCBP2 SMG7 SMG8 SMG5 SMG6 UPF1 PNRC2 UPF3A RBM8A UPF3B MAGOHB RNPS1 PPP2R1A ETF1 UBA52 DCP1A GSPT2 GSPT1 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 PABPC1 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 80%416700 Other semaphorin interactions PTPRC PLXNA1 SEMA6A PLXND1 SEMA6D SEMA7A PLXNA2 TYROBP PLXNA4 SEMA3E ITGA1 ITGB1 SEMA5A PLXNB3 CD72 TREM2 SEMA4A SEMA4D PLXNC1 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 80%5358493 Synthesis of diphthamide-EEF2 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 DNAJC24 EEF2 DEFECTIVE ABCA1 CAUSES TGD%REACTOME DATABASE ID RELEASE 80%5682113 Defective ABCA1 causes TGD APOA1 ABCA1 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.1 Regulation of MECP2 expression and activity NCOR1 TNRC6B TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X HIPK2 CAMK2B MOV10 CAMK2D LBR HDAC2 CAMK2A CREB1 CALM1 CAMK2G AGO3 AGO4 AGO1 AGO2 AURKB PRKACA HTT FOXG1 TNRC6C NCOR2 TNRC6A HDAC3 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 80%4615885 SUMOylation of DNA replication proteins INCENP SUMO3 SUMO2 NUP62 NUP214 NDC1 PIAS4 SEC13 TOP2A NUP210 TOP1 TOP2B NUP133 PCNA NUP93 NUP50 AURKA NUP54 NUP205 POM121 AAAS NUP160 RANGAP1 CDCA8 POM121C NUP42 NUP85 BIRC5 TPR PIAS3 NUP88 NUP43 RAE1 RANBP2 AURKB NUP155 UBE2I NUP153 SUMO1 NUP107 NUP188 NUP35 NUP37 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.1 linifanib-resistant FLT3 mutants FLT3 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9706574 RHOBTB GTPase Cycle HSP90AB1 PDE5A CCT2 TMOD3 TXNL1 GPS1 COPS4 TWF1 COPS2 CDC37 RBMX ACTG1 CCT7 MSI2 CUL3 ROCK2 MYO6 TRA2B CCT6A RBBP6 HNRNPC SRRM1 SPEN RNF20 DDX39B HSP90AA1 PHIP ROCK1 RHOBTB1 RHOBTB2 CPSF7 DBN1 STK38 ACTN1 VIM ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.2 Acyl chain remodelling of PE ABHD4 PLA2G3 PLA2G5 PLA2G2F PLA2G6 PLA2G2D PLA2G2E PNPLA8 PLA2G2A MBOAT1 MBOAT2 LPCAT4 LPCAT3 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G4A PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G10 PLA2G1B PLBD1 PLA2R1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 80%193704 p75 NTR receptor-mediated signalling IKBKB SQSTM1 FGD1 FGD2 FGD3 ARHGEF10L FGD4 HDAC2 MCF2L RIPK2 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 RELA NFKB1 GNA13 NFKBIA OBSCN TRIO HDAC3 HDAC1 PLEKHG5 PREX1 RAC1 TRAF6 VAV1 RASGRF2 SOS1 VAV2 TIAM1 PLEKHG2 NGFR ARHGDIA NGF RHOA SOS2 ABR ADAM17 PSEN1 SMPD2 NCSTN MCF2 TIAM2 MAG BAD KALRN CASP3 NET1 VAV3 AKAP13 YWHAE MAPK8 IRAK1 MYD88 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 ARHGEF6 CASP2 ITSN1 UBA52 UBB ITGB3BP PRDM4 NGEF UBC ARHGEF40 PRKCI RPS27A OMG BEX3 APH1A MAGED1 PSENEN ARHGEF26 RTN4 APH1B PSEN2 BCL2L11 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 AATF ECT2 SORCS3 ARHGEF39 LINGO1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.3 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDKN2A CDK4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 80%428643 Organic anion transporters SLC5A5 SLC25A18 SLC17A6 SLC25A10 SLC17A7 SLC17A8 SLC5A8 SLC17A1 SLC17A5 SLC25A22 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.1 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.1 Plasma lipoprotein clearance CLTC HDLBP APOA1 PCSK9 CLTA VLDLR LIPA LDLRAP1 MYLIP UBA52 CUBN AMN LSR NPC1 SOAT1 SOAT2 NPC2 CES3 LDLR NR1H2 APOC4 NR1H3 UBB APOBR NCEH1 APOC1 UBC RPS27A AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 LIPC APOE APOB SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2644602.1 Signaling by NOTCH1 PEST Domain Mutants in Cancer HEY1 HEY2 HES5 CREBBP HEYL NOTCH1 MAML2 HDAC10 MAML1 HDAC11 HDAC2 RBPJ HDAC8 KAT2B KAT2A SNW1 EP300 HDAC9 HES1 MAML3 MAMLD1 HDAC6 HDAC7 MYC HDAC4 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SKP1 HDAC5 CCNC NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X UBA52 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 ADAM17 PSEN1 RBX1 JAG1 NCSTN P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME DATABASE ID RELEASE 80%193670 p75NTR negatively regulates cell cycle via SC1 NGFR HDAC1 NGF PRDM4 HDAC2 HDAC3 LDL CLEARANCE%REACTOME%R-HSA-8964038.3 LDL clearance CLTC PCSK9 CLTA LIPA AP2S1 LDLRAP1 AP2A1 AP2B1 LSR AP2A2 NPC1 AP2M1 SOAT1 SOAT2 NPC2 CES3 LDLR NCEH1 APOB BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.2 Breakdown of the nuclear lamina CASP6 LMNB1 GLYCOLYSIS%REACTOME%R-HSA-70171.6 Glycolysis NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 GPI PFKFB2 NUP93 PFKFB1 PFKFB4 PFKFB3 NUP50 NUP54 PGP NUP205 POM121 ADPGK AAAS BPGM NUP160 PPP2CA PPP2CB POM121C NUP42 NUP85 GAPDHS PGK1 ENO1 TPR NUP88 PPP2R1A NUP43 RAE1 RANBP2 HK2 PRKACA PPP2R5D HK3 NUP155 ENO2 ENO3 PPP2R1B PGK2 ALDOB NUP153 PFKL TPI1 PGAM2 HK1 GAPDH NUP35 NUP37 GCKR ALDOC PRKACG PRKACB ALDOA PFKM PFKP PGAM1 PGM2L1 NUP107 NUP188 GNPDA1 GNPDA2 GCK TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 80%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 80%72764 Eukaryotic Translation Termination RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 N6AMT1 RPL15 RPL18 ETF1 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 APEH RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 UBA52 GSPT2 GSPT1 TRMT112 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 80%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2AX H2AB1 TINF2 H2AC19 TERF1 TERF2 H2AC14 H2BC12L H2BC21 POT1 TERF2IP H2BU1 H2AC8 H2AC6 NTHL1 H2AC7 H2BC17 H2BC12 H2BC13 MBD4 H2BC14 SMUG1 H2AJ H2BC15 NEIL2 H2BC11 NEIL1 OGG1 H2AZ1 H2BC9 H2AZ2 TDG ACD H4C9 H2BC8 H2BC5 H3-4 H2BC3 H2BC1 H2AC20 NEIL3 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 80%111448 Activation of NOXA and translocation to mitochondria TFDP1 PMAIP1 TFDP2 E2F1 TP53 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.1 Biosynthesis of E-series 18(R)-resolvins ALOX15 ALOX5 LTA4H DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%R-HSA-1168372.3 Downstream signaling events of B Cell Receptor (BCR) IKBKB PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 IKBKG NFATC3 MAP3K7 NFATC2 CHUK NFATC1 PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 CARD11 PSMD10 PSMB11 PSMD12 PSMD11 RASGRP1 PSMD14 CALM1 PSMD13 BCL10 PSMA7 RELA MALT1 PSMB10 FKBP1A PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC NFKB1 PSMB8 PSMB9 NFKBIA PPP3CA SEM1 PSMC5 RASGRP3 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE FBXW11 NFKBIB UBA52 NRAS HRAS CUL1 UBB PPP3R1 UBC RPS27A PPP3CB PPIA RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 80%6802953 RAS signaling downstream of NF1 loss-of-function variants SPRED1 HRAS NF1 SPRED3 SPRED2 NRAS SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 80%6802946 Signaling by moderate kinase activity BRAF mutants CNKSR1 FGB KRAS FGA TLN1 VWF RAF1 VCL CAMK2B FGG CAMK2D YWHAB SRC CAMK2A NRAS MAP3K11 HRAS CALM1 CAMK2G MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 PHB1 ITGB3 CSK ITGA2B ARAF PEBP1 ARRB1 ARRB2 RAP1B RAP1A MARK3 BRAP MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 80%5621575 CD209 (DC-SIGN) signaling ICAM3 RELB PRKACG RELA PRKACB RAF1 PAK1 LYN FYN CD209 PAK3 CREBBP PAK2 NFKB1 PRKACA NRAS HRAS EP300 ICAM2 RPS6KA5 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 80%174417 Telomere C-strand (Lagging Strand) Synthesis CHTF18 TINF2 TERF1 TERF2 POT1 TERF2IP DNA2 PRIM2 PCNA POLD3 PRIM1 POLD4 CHTF8 POLD1 POLD2 RFC5 RFC3 RFC4 BLM LIG1 RFC1 RFC2 RPA2 WRN RPA3 CTC1 STN1 ACD POLA1 POLA2 TEN1 RPA1 FEN1 DSCC1 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 80%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 80%1566977 Fibronectin matrix formation CEACAM8 ITGB1 ITGA5 FN1 CEACAM1 CEACAM6 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 80%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A ANAPC11 PSMD8 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 UBA52 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 CDK1 UBE2D1 ANAPC15 ANAPC16 ANAPC10 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.3 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CITED2 KDM5B CITED4 YEATS4 YY1 CREBBP PITX2 TGFA EGFR ESR1 EP300 MYC NPM1 NOP2 HSPD1 ERBB2 CGA MYBL2 TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 KIT TFAP2E DEK VEGFA KCTD1 CGB8 KCTD15 CDKN1A ATAD2 APOE CITED1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 80%8941332 RUNX2 regulates genes involved in cell migration AKT2 ITGBL1 CBFB AKT1 MMP13 AKT3 ITGA5 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 80%9005891 Loss of function of MECP2 in Rett syndrome NCOR1 TBL1XR1 HDAC1 SIN3A CAMK4 GPS2 TBL1X CALM1 NCOR2 PRKACA HDAC3 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.1 Defective F9 activation GP9 F9 GP1BB F11 GP1BA GP5 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 80%6811440 Retrograde transport at the Trans-Golgi-Network NSF STX16 NAPG VAMP4 STX10 PLIN3 RGP1 TMF1 ARFRP1 SYS1 STX6 RIC1 RAB43 ARL1 RAB6B RABEPK RHOBTB3 NAA30 RAB6A NAA35 VPS51 NAA38 VPS53 VPS52 VPS54 TGOLN2 RAB9A GCC2 NAPA RAB9B GCC1 USP6NL GOLGA1 SCOC ARFIP2 COG8 GOLGA4 COG7 COG6 COG5 COG4 M6PR COG3 COG2 VAMP3 IGF2R COG1 VTI1A NAPB PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.1 Porphyrin metabolism GSTA1 HMOX1 ALB SLCO1B1 SLCO1B3 UGT1A1 ALAD FABP1 UGT1A4 HMOX2 ALAS2 FECH ABCC1 COX15 UROS ABCG2 CPOX PPOX ABCC2 UROD HMBS COX10 BLVRB BLVRA ALAS1 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 80%5637810 Constitutive Signaling by EGFRvIII SHC1 EGF GAB1 PIK3R1 CBL EGFR NRAS PIK3CA CDC37 PLCG1 SOS1 HRAS HSP90AA1 METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.4 Metabolism of cofactors COQ2 DHFR GCHFR GCH1 IDH1 PTS COQ9 COQ7 COQ6 COQ5 NOS3 COQ3 SPR PDSS2 PRKG2 PDSS1 HSP90AA1 AKT1 CALM1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.3 PKA activation in glucagon signalling PRKACG ADCY3 PRKACB ADCY2 ADCY1 ADCY8 ADCY7 ADCY9 ADCY6 ADCY5 PRKAR1B PRKAR1A PRKAR2A PRKACA GNAS PRKAR2B ADCY4 TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.2 TGFBR1 KD Mutants in Cancer SMAD2 TGFB1 SMAD3 TGFBR1 TGFBR2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 80%167287 HIV elongation arrest and recovery ELOB ELOC TCEA1 SSRP1 CCNT2 CCNT1 CCNK POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE ELOA2 SUPT5H CDK9 ELL ELOA SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.3 Synthesis of glycosylphosphatidylinositol (GPI) DPM2 PIGB PIGA PIGO PIGM PIGN PIGL PIGP PIGG PIGZ PIGF PIGW PIGV PIGH PIGY PIGX PIGC ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.2 Essential pentosuria DCXR PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 80%4086400 PCP CE pathway PSMD8 PRKCG PSMD9 PRKCA PSMD6 PSMD7 PFN1 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 WNT1 PSMD13 PSMA7 PSMB10 RAC2 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 FZD7 PSMC1 PSMC2 DVL1 DVL2 DVL3 CLTC CLTA SCRIB RAC1 RAC3 UBA52 WNT4 VANGL2 WNT5B ROR1 ROR2 PRICKLE1 SMURF2 UBB SMURF1 DAAM1 UBC RPS27A RHOA AP2S1 AP2A1 PARD6A FZD1 AP2B1 AP2A2 FZD8 AP2M1 WNT5A ARRB2 WNT11 RYK FZD3 FZD2 FZD5 FZD4 CLTB FZD6 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME DATABASE ID RELEASE 80%6782210 Gap-filling DNA repair synthesis and ligation in TC-NER TCEA1 ZNF830 PCNA POLD3 POLD4 POLD1 POLD2 EP300 POLK POLE RFC5 ISY1 RFC3 USP7 RFC4 HMGN1 LIG1 RFC1 RFC2 RPA2 XRCC1 LIG3 POLE4 RPA3 POLE2 UVSSA POLE3 RPA1 CCNH UBA52 AQR PPIE POLR2A POLR2B POLR2C POLR2D UBB POLR2E POLR2F ERCC8 POLR2G POLR2H UBC POLR2I POLR2J PRPF19 POLR2K CDK7 RPS27A POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CUL4A DDB1 ERCC3 ERCC2 CUL4B XAB2 RBX1 ERCC6 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.1 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 80%166166 MyD88-independent TLR4 cascade IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 TICAM2 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 MAPK3 PPP2R1A LY96 CD14 DUSP4 BTRC DUSP3 NFKB1 PPP2R5D VRK3 DUSP6 NFKBIA MAP2K3 DUSP7 UBE2N TLR4 MAPK7 TAB3 PPP2R1B TAB2 SKP1 TAB1 FBXW11 NFKBIB TBK1 MAPK11 APP UBE2D3 HMGB1 TRAF6 CASP8 UBA52 NKIRAS1 NKIRAS2 IKBKE TICAM1 CUL1 ELK1 CREB1 UBB IRF3 TRAF3 MAP2K1 IRF7 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER TANK S100A12 RIPK1 FADD RIPK3 S100B NFKB2 SAA1 PTPN11 UBE2D2 ATF2 UBE2D1 MEF2A BIRC2 MEF2C BIRC3 RPS6KA3 RPS6KA5 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME DATABASE ID RELEASE 80%167200 Formation of HIV-1 elongation complex containing HIV-1 Tat CCNH ELOB ELOC TCEA1 SSRP1 CCNT1 POLR2A SUPT16H POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 ELOA2 SUPT5H CDK9 ERCC3 ELL ERCC2 ELOA RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.1 Resistance of ERBB2 KD mutants to trastuzumab CDC37 HSP90AA1 ERBB2 ERBIN DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.2 Defective EXT2 causes exostoses 2 GPC2 EXT1 GPC5 EXT2 GPC4 AGRN GPC6 HSPG2 SDC4 SDC2 SDC3 GPC1 GPC3 SDC1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.2 Interaction between PHLDA1 and AURKA PHLDA1 AURKA REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 80%418359 Reduction of cytosolic Ca++ levels ATP2A1 SLC8A1 SLC8A2 ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 SRI CALM1 ATP2A3 ATP2A2 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 80%9703648 Signaling by FLT3 ITD and TKD mutants PIM1 FLT3 GRB2 BCL2L1 GAB2 NOX4 PIK3R1 NRAS PIK3CA SOS1 HRAS STAT5A STAT5B PTPN11 CDKN1A CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 80%1793185 Chondroitin sulfate dermatan sulfate metabolism XYLT2 XYLT1 CHPF IDS CSGALNACT1 CSGALNACT2 B4GALT7 CHST11 CHST12 IDUA DSEL CHST15 B3GAT3 CHST13 B3GAT2 B3GAT1 UST HYAL1 HYAL3 DSE CHST7 CHPF2 DCN CHSY3 ARSB CHST14 CHSY1 CHST3 SDC4 NCAN SDC2 SDC3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 GPC5 CSPG4 GPC4 AGRN GPC6 HSPG2 BCAN HEXB HEXA REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 80%9694686 Replication of the SARS-CoV-2 genome VHL DDX5 ZCRB1 RB1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.3 Non-integrin membrane-ECM interactions PRKCA LAMC2 LAMC1 PDGFB ITGB5 SDC4 TTR SDC2 SDC3 FGF2 SDC1 NRXN1 THBS1 CASK VTN ITGAV AGRN DAG1 TRAPPC4 HSPG2 ITGB4 LAMA5 NTN4 LAMB2 ITGB3 ITGA6 LAMA3 LAMC3 TGFB1 ITGA2 LAMA4 PDGFA DDR1 ITGB1 LAMA2 LAMA1 LAMB3 DDR2 TNC DMD LAMB1 ACTN1 HCN CHANNELS%REACTOME%R-HSA-1296061.3 HCN channels HCN2 HCN1 HCN4 HCN3 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.2 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNGT2 CCT3 CCT2 TCP1 CCT6B GNA14 GNA15 GNG3 GNG2 GNG5 RGS9 GNG4 RGS6 GNA11 RGS7 GNG7 GNG8 CCT8 CCT7 CCT5 CCT4 RGS11 GNG10 GNG12 GNG11 GNG13 CCT6A CSNK2A1 GNAQ GNB2 CSNK2A2 GNB1 GNB4 PDCL GNB3 GNB5 CSNK2B GNGT1 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 80%9672395 Defective F8 binding to the cell membrane F8 HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.1 HS-GAG degradation GPC2 GPC5 GPC4 HPSE AGRN HPSE2 GPC6 SGSH HSPG2 NAGLU IDS GUSB SDC4 SDC2 IDUA SDC3 GLB1L GPC1 GLB1 GPC3 SDC1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.2 Signaling by NOTCH2 HES5 NOTCH2 UBA52 MAML2 MAML1 RBPJ GZMB EP300 HES1 MAML3 CREB1 MAMLD1 UBB MDK UBC RPS27A CNTN1 APH1A PSENEN APH1B PSEN2 JAG2 ADAM10 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 PSEN1 JAG1 NCSTN FCER2 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.2 Defective ALG12 causes CDG-1g ALG12 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 80%9758890 Transport of RCbl within the body ABCD4 LRP2 ABCC1 LDLRAP1 LMBRD1 TCN1 TCN2 CD320 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 80%8963743 Digestion and absorption RSC1A1 CHIT1 CLPS PNLIP CHIA AMY2A AMY1A AMY2B AMY1B SI TREH AMY1C LCT GUCY2C SLC2A5 PNLIPRP1 PNLIPRP2 GUCA2B CEL GUCA2A ALPI LIPF MGAM PIR PNLIPRP3 SLC2A2 SLC5A1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME%R-HSA-180689.1 APOBEC3G mediated resistance to HIV-1 infection PSIP1 PPIA BANF1 HMGA1 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 80%9700649 Drug resistance of ALK mutants ALK RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 80%5213460 RIPK1-mediated regulated necrosis FAS CASP8 UBA52 PDCD6IP CDC37 MLKL XIAP FLOT1 OGT TRAF2 UBB SDCBP UBC TNFSF10 RPS27A PELI1 RIPK1 FADD RIPK3 TNFRSF10B TNFRSF10A TRADD FASLG HSP90AA1 BIRC2 FLOT2 STUB1 BIRC3 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 80%5678520 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 80%5663220 RHO GTPases Activate Formins INCENP DIAPH1 KIF2A SEC13 NUP133 KIF2C KIF2B CENPE CENPF TAOK1 NUP160 PPP2CA PPP2CB NUP85 PPP1CC NUP43 RANBP2 AURKB BUB1 CLASP2 CLIP1 RPS27 ITGB1 MAD1L1 FMNL3 FMNL1 FMNL2 NUP37 DVL1 DVL2 DVL3 CDC42 NDC80 RAC1 SPDL1 RANGAP1 BIRC5 RHOA BUB1B EVL CDC20 BUB3 MAD2L1 SRF NSL1 PPP2R5E SRGAP2 PPP2R5B PPP2R5A PPP2R5C ZW10 PFN1 DIAPH3 PFN2 DSN1 ACTB SCAI RCC2 ZWINT AHCTF1 XPO1 NDEL1 PPP2R1A RHOC RHOD PPP2R5D RHOB PPP2R1B MIS12 DYNLL1 CKAP5 DYNC1I1 MAPRE1 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L MRTFA ZWILCH DYNC1LI1 DYNC1LI2 ACTG1 ITGB3BP DAAM1 KIF18A CENPA CENPC KNTC1 CDCA8 CENPT CENPU SGO1 CLASP1 SGO2 SKA1 SKA2 DYNC1H1 NDE1 PLK1 PMF1 CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 NUDC DYNLL2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 80%190375 FGFR2c ligand binding and activation FGF1 FGF16 FGF2 FGF18 FGF4 FGF6 FGF9 FGF20 FGF23 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 80%5218920 VEGFR2 mediated vascular permeability CDH5 PAK1 TRIB3 CTNNA1 PDPK1 MAPKAP1 RAC1 AKT3 PAK3 PAK2 VAV1 NOS3 AKT2 MLST8 AKT1 RICTOR VAV2 VAV3 CALM1 MTOR CTNNB1 THEM4 PRR5 JUP HSP90AA1 CTNND1 CAV1 DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 80%9605308 Diseases of Base Excision Repair NEIL3 NTHL1 NEIL1 OGG1 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.1 Resistance of ERBB2 KD mutants to sapitinib CDC37 HSP90AA1 ERBB2 ERBIN RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.1 RUNX3 Regulates Immune Response and Cell Migration ITGA4 CBFB RUNX3 SPP1 ITGAL ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.3 Activation of Na-permeable kainate receptors GRIK1 GRIK2 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.2 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A CDK4 MPS I - HURLER SYNDROME%REACTOME DATABASE ID RELEASE 80%2206302 MPS I - Hurler syndrome IDUA BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 80%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BID PMAIP1 BBC3 STAT3 BAD BMF BCL2L1 BCL2 BCL2L11 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.1 HCMV Early Events NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 H2AW DAXX H2AC17 EZH2 H2AC12 H2AC1 H2BC18 H3C15 NUP93 TRIM28 H2AC21 NUP50 NUP54 NUP205 SUZ12 POM121 AAAS NUP160 CBX1 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 NFKB1 NUP155 EED ITGB1 NUP153 PML NUP35 NUP37 NCOR2 HDAC3 NCOR1 TBL1XR1 DYNLL1 GPS2 H2AC19 TBL1X DYNC1I1 H2AC14 H2BC21 EGFR H2BU1 H2AC8 H2AC6 H2AC7 DYNC1I2 H2BC17 H2BC12 H2BC13 ELK1 H2BC14 DYNC1LI1 CREB1 H2BC15 DYNC1LI2 H2BC11 RBBP4 RBBP7 H2BC9 H4C9 H2BC8 DYNC1H1 H2BC5 H2BC3 H2BC1 H2AC20 NUP107 NUP188 H3C8 DYNLL2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.2 ChREBP activates metabolic gene expression ACACB ACACA FASN MLX AGPAT1 ACLY MLXIPL DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.2 Defective MMAA causes MMA, cblA type MMUT MMAA N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 80%975577 N-Glycan antennae elongation ST8SIA6 MGAT4A MGAT4B ST8SIA3 B4GALT6 B4GALT4 B4GALT1 B4GALT5 MGAT5 ST3GAL4 ST6GAL1 B4GALT2 B4GALT3 MGAT4C ST8SIA2 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 80%9673770 Signaling by PDGFRA extracellular domain mutants PIK3CA SOS1 HRAS STAT3 PIK3CB PIK3R2 PDGFRA STAT1 PIK3R1 NRAS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 80%2173788 Downregulation of TGF-beta receptor signaling PPP1R15A USP15 NEDD4L UBA52 PMEPA1 UCHL5 SMAD7 BAMBI STRAP SMURF2 UBB SMURF1 UBC XPO1 PPP1CA RPS27A PPP1CB PPP1CC SMAD2 TGFB1 SMAD3 TGFBR1 TGFBR2 MTMR4 STUB1 LDL REMODELING%REACTOME%R-HSA-8964041.2 LDL remodeling CETP MTTP P4HB APOF LPA APOB BUDDING AND MATURATION OF HIV VIRION%REACTOME%R-HSA-162588.2 Budding and maturation of HIV virion UBAP1 CHMP4A CHMP6 CHMP7 VPS28 CHMP5 NEDD4L UBA52 PDCD6IP UBB UBC RPS27A TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 PPIA VPS37C VPS37D VPS37A VPS37B CHMP2B CHMP4C CHMP2A CHMP4B CHMP3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 80%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC11 FZR1 CDC23 CDC26 CDC20 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC15 UBE2D1 ANAPC1 CDC14A ANAPC2 ANAPC16 ANAPC10 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.2 Integrin signaling FGB FGA TLN1 VWF PDPK1 SHC1 FGG SRC CRK SOS1 AKT1 PTK2 RASGRP2 RASGRP1 SYK RAPGEF3 RAPGEF4 PTPN1 ITGB3 CSK ITGA2B RAP1B RAP1A FN1 APBB1IP BCAR1 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.1 Sensory processing of sound by inner hair cells of the cochlea TWF1 KCNMB1 CLIC5 RIPOR2 CIB2 PJVK ESPN SPTBN1 EPS8 CACNA1D PLS1 TPRN TMC1 ATP2B1 MYO7A TMC2 MYO3B MYO3A KCNQ4 CAPZA1 FSCN2 TWF2 CAPZA2 PCDH15 RAB3A USH1C ESPNL EPB41L1 EPB41L3 SPTAN1 CACNB2 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN LHFPL5 TMIE USH1G STRC MYO15A SNAP25 STX1A DNAJC5 PCLO BSN CACNA2D2 SYP CABP2 CABP1 LRRC52 OTOF SLC17A8 CASK MSN MYH9 SYN1 VAMP2 EZR CAPZB RDX MYO1C KCNMA1 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.1 tRNA Aminoacylation RARS1 KARS1 MARS1 YARS1 YARS2 DARS1 NARS2 WARS1 RARS2 AIMP1 GARS1 CARS2 VARS2 AIMP2 SARS1 EPRS1 NARS1 MARS2 QARS1 DARS2 SARS2 PPA1 LARS1 IARS1 FARSA IARS2 EEF1E1 WARS2 CARS1 TARS1 FARSB VARS1 PARS2 EARS2 LARS2 PPA2 TARS2 AARS2 HARS2 FARS2 HARS1 AARS1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 80%163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. PM20D1 COX6C LRPPRC NDUFAB1 TACO1 COX6A1 COX6B1 COX19 COX16 COX18 NDUFC2 COX11 COX14 NDUFS3 CYCS COX20 COX4I1 NDUFA4 TMEM126B SLC25A27 ATP5MC1 UCP3 UCP2 UCP1 SLC25A14 UQCRH DMAC2L CYC1 UQCRQ ATP5PF NDUFA5 MT-CYB ATP5PD ETFA ATP5PB ATP5MC2 ATP5MC3 ATP5F1C ATP5F1D NDUFAF6 ATP5F1E NDUFAF7 MT-ATP8 NDUFAF4 MT-ATP6 NDUFAF5 ATP5PO ATP5MG NDUFAF2 ATP5MF ATP5ME NDUFAF3 NDUFAF1 NDUFB10 NDUFB11 COQ10B COQ10A COA1 NDUFB8 ATP5F1A NDUFA13 ATP5F1B NDUFA11 NDUFA12 NDUFA10 ETFDH MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 UQCRC1 UQCRC2 NDUFC1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 ACAD9 MT-CO1 NUBPL NDUFV3 NDUFV2 NDUFV1 UQCRFS1 COX7A2L NDUFS8 SCO1 NDUFS7 SCO2 NDUFS6 NDUFS5 MT-CO2 NDUFS4 MT-CO3 NDUFS2 NDUFS1 SDHC SDHD TMEM186 SDHA ETFB SDHB TIMMDC1 SURF1 ECSIT TRAP1 COX7B UQCR11 UQCR10 COX7C COX8A COX5B COX5A RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 80%77075 RNA Pol II CTD phosphorylation and interaction with CE CCNH POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 SUPT5H ERCC3 RNMT RNGTT ERCC2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.3 AURKA Activation by TPX2 CEP57 YWHAE CETN2 CEP164 CCP110 ACTR1A PCM1 TUBA1A PPP2R1A HMMR CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 HSP90AA1 CEP135 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 AURKA HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 NDE1 TPX2 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME DATABASE ID RELEASE 80%5619049 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 80%9617629 Regulation of FOXO transcriptional activity by acetylation KAT2B FOXO4 EP300 FOXO3 FOXO1 SIRT3 CREBBP TXNIP SIRT1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.2 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 TFAP2A TFAP2C PITX2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 80%2206307 MPS IIIA - Sanfilippo syndrome A SGSH GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 80%389661 Glyoxylate metabolism and glycine degradation DAO PXMP2 GNMT NDUFAB1 LIPT2 LIPT1 DBT BCKDHA AGXT2 PDHB AGXT ALDH4A1 GLDC BCKDHB LIAS GCSH PRODH2 HOGA1 DDO DLAT AMT PDHX PDHA2 PDHA1 GRHPR OGDH DLST HAO1 GOT2 DHTKD1 DLD PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 80%392851 Prostacyclin signalling through prostacyclin receptor GNGT2 GNG10 GNG12 GNG11 GNG13 GNB2 GNAS GNB1 GNB4 GNG3 GNB3 PTGIR GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.2 Defective PMM2 causes CDG-1a PMM2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 80%2428928 IRS-related events triggered by IGF1R IRS1 TRIB3 FLT3 PIK3CB PDPK1 PIK3R4 FLT3LG GAB1 GAB2 PIK3R1 TLR9 KLB NRAS PIK3CA SOS1 AKT2 HRAS FRS2 FGF1 IGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 IRS2 FGF19 PIK3C3 PIK3R2 FGFR4 THEM4 FGF16 FGF7 FGF18 PDE3B IRS4 IGF1R IGF2 PTPN11 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-HSA-192105.2 Synthesis of bile acids and bile salts SLC27A2 OSBPL1A PTGIS CYP8B1 OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 CH25H HSD3B7 AKR1C1 AKR1D1 AKR1C3 NR1H4 AKR1C2 AKR1C4 ACOT8 CYP7B1 ABCB11 NCOA2 BAAT CYP7A1 CYP27A1 AMACR HSD17B4 NCOA1 ACOX2 SLC27A5 CYP46A1 CYP39A1 RXRA OSBP INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.2 Interleukin-23 signaling IL12RB1 STAT3 TYK2 IL23R IL23A P4HB STAT4 IL12B JAK2 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 80%9656223 Signaling by RAF1 mutants CNKSR1 FGB FGA TLN1 VWF RAF1 VCL CAMK2B FGG CAMK2D YWHAB SRC CAMK2A NRAS HRAS CALM1 CAMK2G MAP2K1 BRAF IQGAP1 MAPK1 MAPK3 ITGB3 CSK ITGA2B ARAF ARRB1 ARRB2 RAP1B RAP1A MARK3 MAP2K2 KSR1 FN1 KSR2 CNKSR2 JAK2 APBB1IP FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.1 FGFR4 mutant receptor activation FGFR4 FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 80%9682385 FLT3 signaling in disease ZMYM2 PIM1 FLT3 MYO18A BCL2L1 FLT3LG GAB2 TRIP11 PIK3R1 UBA52 CBL NRAS PIK3CA SPTBN1 SOS1 HRAS UBB ETV6 UBC RPS27A GRB2 GOLGB1 NOX4 STAT5A STAT5B PTPN11 CDKN1A TCR SIGNALING%REACTOME DATABASE ID RELEASE 80%202403 TCR signaling IKBKB HLA-DPB1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 HLA-DQA2 VASP PSMD1 HLA-DQA1 IKBKG MAP3K7 CHUK PSMA5 CDC34 HLA-DRB5 PSMA6 HLA-DRB4 PSMA3 PSMA4 PSMA1 PRKCQ PSMA2 PSME3 UBE2V1 RIPK2 PSME4 HLA-DQB2 PSME1 HLA-DQB1 PSME2 CARD11 TRBV12-3 PSMD10 HLA-DRB3 TRBV7-9 HLA-DRB1 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 HLA-DRA BCL10 ZAP70 PSMA7 RELA MALT1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TRAV8-4 PSMB1 PSMF1 NFKB1 PSMB8 PSMB9 NFKBIA PTPN22 SEM1 UBE2N PSMC5 TAB2 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CD101 PAK1 PDPK1 LCK LAT TRAF6 INPP5D PAK3 PAK2 PIK3R1 PAG1 PIK3CA PLCG1 NCK1 CD3G PTPRJ CD3E CD3D PIK3R2 EVL CSK TRAV29DV5 PIK3CB TRAT1 GRAP2 PLCG2 LCP2 PTPRC TRAC CD4 BTRC PTEN SKP1 FBXW11 WAS UBA52 TRBC1 CUL1 TRAV19 UBB UBC RPS27A FYB1 ITK HLA-DPA1 ENAH UBE2D2 UBE2D1 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.2 Extrinsic Pathway of Fibrin Clot Formation F7 F10 F9 TFPI F3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 80%381033 ATF6 (ATF6-alpha) activates chaperones MBTPS1 HSPA5 HSP90B1 NFYA NFYB DDIT3 CALR NFYC ATF6 ATF4 MBTPS2 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ITGB1 PXN ILK PARVA PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.2 Processing and activation of SUMO SENP2 RWDD3 SUMO3 SUMO2 UBA2 SAE1 UBE2I SUMO1 SENP5 SENP1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 80%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS1 TRIB3 FLT3 PIK3CB PDPK1 PIK3R4 FLT3LG GAB1 GAB2 PIK3R1 TLR9 KLB NRAS PIK3CA SOS1 AKT2 HRAS FRS2 FGF1 IGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 IRS2 FGF19 PIK3C3 PIK3R2 FGFR4 THEM4 FGF16 FGF7 FGF18 PDE3B CILP IRS4 IGF1R IGF2 PTPN11 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.2 Ca activated K+ channels KCNMB4 KCNN4 KCNN2 KCNMB1 KCNMB2 KCNN1 KCNMA1 KCNMB3 KCNN3 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.4 Protein-protein interactions at synapses GRIA3 GRIA4 GRIA1 GRM5 GRIN2C GRIN2B FLOT1 GRIN1 GRIN2D GRIN2A DLG1 DLG2 DLG3 IL1RAPL1 DLG4 EPB41L1 EPB41L3 SYT2 HOMER3 SYT9 EPB41 SHANK3 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 LIN7B FLOT2 RTN3 PTPRS SIPA1L1 PTPRF DLGAP1 DLGAP3 LRFN3 DLGAP2 PTPRD DLGAP4 LRFN2 LRFN4 BEGAIN LRFN1 APBA3 APBA2 STX1A LRRC4B SYT7 LRRTM3 LRRTM4 LRRTM1 NTRK3 LRRTM2 IL1RAPL2 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 CASK NRXN1 NRXN3 LIN7A NRXN2 LIN7C SLITRK2 SLITRK1 SLITRK4 APBA1 SLITRK6 PDLIM5 NLGN4Y NLGN4X SHARPIN SYT12 SYT1 SYT10 SLITRK3 SLITRK5 PPFIA1 PPFIA4 DBNL PPFIA3 PPFIA2 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.2 Metallothioneins bind metals MT1E MT1M MT2A MT1X MT4 MT3 MT1A MT1F MT1G MT1H MT1B DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 80%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT2 POMT1 DAG1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.3 Terminal pathway of complement C8A C6 C8G C7 C9 CLU C5 C8B B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 80%983705 B Cell Activation IGKV1-17 IKBKB PSMD8 IGKV1-12 PSMD9 IGHV3-7 PSMD6 IGHV3-9 PSMD7 PSMD4 IGHV3-30 PSMD5 PSMD2 PSMD3 PSMD1 IGHV3-33 NFATC3 IKBKG MAP3K7 NFATC2 IGKV1D-39 NFATC1 CHUK PRKCB IGKV1D-33 PSMA5 PSMA6 IGKV2D-28 PSMA3 IGKV4-1 PSMA4 IGHV7-81 SH3KBP1 PSMA1 PSMA2 PSME3 PSME4 PSME1 IGKV2D-30 PSME2 CARD11 PSMD10 IGHV4-59 IGHV1-69 PSMB11 PSMD12 PSMD11 RASGRP1 PSMD14 CALM1 PSMD13 IGLV2-11 BCL10 IGLV1-40 IGLV1-47 PSMA7 IGLV6-57 RELA IGLV2-14 MALT1 IGLV1-44 PSMB10 FKBP1A IGKV3-15 PSMA8 IGKV3-11 PSMB6 LYN PSMB7 PSMB4 PSMB5 IGKV2D-40 PSMB2 IGHV3-11 PSMB3 IGHV3-13 PSMB1 PSMF1 IGKV1D-16 IGLV7-43 NFKB1 IGKV1D-12 PSMB8 IGLV1-51 PSMB9 NFKBIA IGLV2-23 SEM1 PSMC5 PSMC6 PSMC3 IGKV3-20 PSMC4 IGHV4-34 PSMC1 IGHV1-2 PSMC2 REL IGHV1-46 NFKBIE IGHV4-39 NFKBIB IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 FYN IGLV3-19 PIK3R1 VAV1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 NRAS IGHV3-48 IGLV3-25 IGLV3-27 SOS1 IGKC HRAS IGKV1-39 IGLV3-21 IGKV1-33 NCK1 IGHV3-53 IGLC7 IGKV5-2 CD22 IGKV1-5 IGLC6 AHCYL1 STIM1 CD79B ORAI2 CD79A ORAI1 BTK PIK3CD ITPR1 ITPR2 ITPR3 CD19 PIK3AP1 PLCG2 SYK PTPN6 IGHM BTRC PPP3CA BLNK RASGRP3 SKP1 BLK FBXW11 TRPC1 IGHD UBA52 CUL1 DAPP1 UBB PPP3R1 UBC RPS27A PPP3CB PPIA IGHV3-23 IGLV IGLV2-8 IGKV1-16 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9012999 RHO GTPase cycle SRC AAAS DDX4 ROCK1 TNFAIP1 RND3 MUC13 FLOT2 WDR6 CKB FAM83B DSP ANKRD26 DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F PLD1 PTPN13 PLD2 CKAP4 KTN1 NISCH CCDC88A VANGL2 UBXN11 DLG5 CPD KCTD13 DSG1 PKP4 RBMX PICALM MTR SRRM1 DDX39B VAV3 CCP110 HSP90AA1 CYFIP2 ITSN2 ANKLE2 WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L PREX2 GJA1 WDR91 EPSTI1 ANKFY1 CEP97 FNBP1 STARD8 FRS2 FRS3 DAAM1 WDR81 NGEF MTMR1 SHMT2 IQGAP1 IQGAP2 IQGAP3 MYO6 HMOX2 STARD13 JUP FAM135A HNRNPC CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 NUDC RRAS2 GMIP CIT CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 PKN3 GPS1 FGD1 FGD2 FGD3 FGD4 FGD5 CHN2 CHN1 STX5 FARP2 FARP1 KIDINS220 WWP2 DEF6 WDR11 LETM1 TMEM59 SHKBP1 PKN2 GOPC FILIP1 PKN1 UHRF1BP1L FAM13B PLXND1 FAM13A MSI2 STK10 SLK POTEE GOLGA8R LAMTOR1 TPM4 TPM3 RALGAPA1 FAM91A1 TEX2 ARMCX3 OBSCN ITGB1 NCKAP1 PHIP CYFIP1 TRIO NCF1 TFRC RHOBTB1 NCF2 RHOBTB2 STIP1 SNAP23 NCF4 DDRGK1 ARHGAP1 STK38 BRK1 ARHGAP39 ARHGAP5 PLXNA1 ARHGAP6 SRGAP3 ARHGAP35 SRGAP1 DOCK10 SYDE1 PREX1 ARHGAP42 COPS4 BAIAP2L1 NSFL1C OPHN1 STBD1 ARHGDIB COPS2 PIK3R1 RAC3 EMD PLXNB1 LBR MAP3K11 GIT1 ARHGAP11A PIK3CA TMPO SWAP70 ZNF512B CDC37 ARHGAP11B ARAP2 RASGRF2 SOS1 CYBB TAGAP ARAP3 EFHD2 CYBA NCK2 OCRL VRK2 LEMD3 NCK1 VAV2 BCR PLEKHG3 TIAM1 DEPDC1B PLEKHG4 RAPGEF1 PLEKHG1 CDC42EP1 PLEKHG2 PLEKHG6 DSG2 ARFGAP3 RAB7A EPHA2 VAMP3 NIPSNAP2 ARFGAP2 GARRE1 AMIGO2 NOXO1 PIK3R2 ARHGAP17 SOS2 SLC1A5 ROCK2 ARHGAP15 LMAN1 ABR PARD6B ARHGAP21 PARD6A PGRMC2 ARL13B RACGAP1 SH3BP1 SLITRK3 NHS CSK ABL2 RBBP6 SLITRK5 WHAMM NCKAP1L WASF3 WASF1 RNF20 SRGAP2 WASF2 NDUFA5 YKT6 PCDH7 CDC42BPB PAK4 CDC42BPA IL32 GIT2 JAG1 CPNE8 CAV1 MCAM GOLGA3 MCF2 BAIAP2L2 ACTN1 ARHGAP26 BAIAP2 TIAM2 MPP7 VANGL1 SPATA13 ARHGAP32 DIAPH3 TAOK3 CFTR ABI2 ABI1 NOXA1 GRB7 NOX3 TMEM87A ESYT1 NOX1 PIK3R3 FERMT2 TWF1 KALRN SCFD1 SPTBN1 STAM NET1 ANLN FAF2 KIF14 WASL USP9X SH3RF1 AKAP12 AKAP13 HINT2 SH3PXD2A RAC2 SPTAN1 CCDC115 RHOG RHOH RHOF RHOC RHOD RHOB ARHGEF9 RHOJ ARHGEF3 ARHGEF4 RHOU ARHGEF1 ARHGEF2 RHOV ARHGEF7 RHOQ DBN1 ARHGEF5 ARHGEF6 C1QBP WAS SAMM50 PLEKHG4B EMC3 PAK6 PAK5 BCAP31 CAVIN1 MTX1 MYO9B MYO9A DLC1 TRIP10 STEAP3 RTKN PRAG1 ARHGDIG ACTG1 SYDE2 ARHGAP44 ARHGAP40 BASP1 ARHGEF40 RALBP1 KCTD3 ARHGAP45 ALDH3A2 ELMO2 STAM2 ARHGEF26 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 TOR1AIP1 ARHGAP12 ARHGAP22 ARHGAP20 RHPN1 RHPN2 ECT2 CPSF7 ACBD5 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 DIAPH2 ARHGAP31 DNMBP ARHGAP30 SOWAHC ARHGEF10L RND2 RND1 LMNB1 MCF2L DBT FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 ARAP1 SENP1 ZAP70 ARHGAP10 ALS2 GFOD1 PEAK1 NDUFS3 CCDC187 MOSPD2 ADD3 FAM169A UACA GNA13 TRA2B PTK2B STOM SPEN HSPE1 SLC4A7 FMNL3 FMNL1 FMNL2 ACTC1 VIM PDE5A CUL3 RASAL2 DOCK11 HSP90AB1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 DOCK7 CAPZB DOCK2 DOCK1 HGS CDC42 CLTC PAK1 LCK RAC1 PAK3 PAK2 VAV1 VCP ARHGDIA RHOA ACTB CCT6A VAPB TUBA1B CCT2 CCT7 ERBIN ATP6AP1 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.1 Signaling by EGFR in Cancer RPS27A AREG SHC1 EGF GAB1 PIK3R1 UBA52 CBL TGFA EGFR NRAS PIK3CA CDC37 PLCG1 EPGN SOS1 HRAS HSP90AA1 BTC HBEGF EREG UBB UBC PRE-MRNA SPLICING%REACTOME%R-HSA-72163.2 pre-mRNA splicing TXNL4A SNRPN WBP11 PRPF4 YBX1 PRPF6 HNRNPUL1 PRPF3 SNRNP27 PPIH SNRNP200 SNRPC SNRPA PRPF8 CPSF4 CPSF1 FUS CPSF3 CPSF2 CWC15 CHERP LSM8 ISY1 DDX46 DDX42 PPWD1 USP39 ELAVL1 ELAVL2 SART1 SNRNP70 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 DNAJC8 RBM22 WBP4 PRCC TRA2B DDX23 CSTF2T PABPN1 PUF60 SNRPB2 SMNDC1 HNRNPA0 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 PPIL3 PPIL4 PPIL6 RBMX POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L EIF4A3 CASC3 MAGOH NCBP1 NCBP2 CDC40 SRRM1 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF UPF3B MAGOHB RNPS1 PTBP1 SNW1 GTF2F1 DHX9 GTF2F2 HNRNPH1 HNRNPA1 HNRNPM HNRNPF HSPA8 SNRPD2 SNRPD1 SNRPD3 DDX5 SNRPG SNRPE SNRPF SNRPB LSM5 LSM4 LSM3 LSM2 HNRNPU HNRNPR LSM7 CCAR1 CLP1 LSM6 SRRM2 AQR CRNKL1 CD2BP2 SF1 CSTF3 CSTF2 PPIE SNU13 PCBP1 CSTF1 SYMPK PRPF38A HNRNPL FIP1L1 HNRNPK HNRNPD SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PCBP2 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 HNRNPC SRSF10 HNRNPA2B1 SF3A3 SNRPA1 SF3A1 SF3A2 NUDT21 XAB2 PHF5A PRPF31 CWC25 CWC27 CPSF7 EFTUD2 CWC22 PAPOLA MTREX AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 80%71291 Amino acid and derivative metabolism RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA SLC25A15 ARG2 RPS3A RPL9P9 SLC25A2 CPS1 ASL DBT NAGS NMRAL1 RPL37A ASS1 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 AGXT2 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 TXN2 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 GCDH RPL35A HYKK RPL23A AADAT RPL3L OGDH RPS26 PIPOX RPS25 DLST RPS28 SLC25A21 RPS27 CRYM ALDH7A1 RPS29 RPL27A DLD AASS RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 DIO1 CKB DIO2 RARS1 DIO3 KARS1 MARS1 DARS1 AIMP1 AIMP2 SARS1 EPRS1 QARS1 LARS1 IARS1 EEF1E1 MTRR SLC44A1 MTR ALDH4A1 PRODH PRODH2 ODC1 OAZ1 OAZ2 OAZ3 NQO1 AZIN1 ACAT1 SEPHS2 PSTK SECISBP2 GPT CKMT2 GATM EEFSEC SLC6A8 SEPSECS CKM CKMT1B PAH SLC6A12 SLC6A11 GADL1 CSAD ADO MPST TSTD1 BHMT2 SQOR SLC5A5 SLC6A7 GOT2 SUOX BHMT TST ETHE1 CDO1 SLC7A5 CBS CTH SCLY HNMT SLC25A10 GNMT UBA52 SLC3A2 GLS BCKDHA MCCC2 SLC36A4 ACAD8 HIBADH MCCC1 BCKDHB RPS27A PPM1K ACADSB BCKDK ALDH6A1 AUH IVD BCAT1 SLC25A44 HIBCH BCAT2 MTAP ARG1 TPH2 DDC PSMD8 TPH1 PSMD9 AANAT PSMD6 ASMT PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 NDUFAB1 GLUD1 PSMA6 GLUD2 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PDHB RPS6 PSMD13 PSMA7 DUOX1 TPO IYD PSMB10 PSMA8 DUOX2 OAT PSMB6 PYCR1 DLAT PSMB7 SRR PYCR2 PSMB4 PSAT1 PYCR3 PHGDH PSMB5 PDHX KYAT1 PSMB2 SERINC1 RIMKLA PSMB3 PDHA2 SERINC3 RIMKLB PSMB1 PDHA1 SERINC2 PSMF1 SERINC5 PSPH PSMB8 SERINC4 PSMB9 MAT1A SEM1 PSMC5 PSMC6 NNMT PSMC3 PSMC4 PAPSS1 PSMC1 PSMC2 DMGDH ASNS CHDH GLS2 SARDH PNMT TH AHCY DBH TXNRD1 PAPSS2 QDPR IL4I1 HGD TAT PCBD1 FAH GSTZ1 HPD ASRGL1 GLUL INMT PHYKPL SDS GAMT AFMID RIDA SMS HAO1 AMDHD1 CARNMT1 SRM UROC1 SLC45A2 KYAT3 DAO PXMP2 KMO NAT8L TDH LIPT2 LIPT1 SDSL SAT1 ACMSD PAOX AGMAT AMD1 SLC25A12 FTCD AGXT SLC25A13 APIP LIAS TYR HAL HDC DDO HAAO CGA FOLH1B GOT1 GRHPR ADI1 MRI1 DCT ENOPH1 TDO2 TSHB IDO2 OTC IDO1 CARNS1 HSD17B10 TMLHE SHMT1 GCAT BBOX1 ALDH9A1 ECHS1 GLDC RPL4 GCSH RPL5 HOGA1 RPL30 RPL3 OCA2 RPL32 RPL31 AMT RPL34 ASPG RPLP1 ASPA RPL10L TYRP1 RPLP0 RPL10A RPL8 NAALAD2 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 FOLH1 RPS17 AZIN2 RPS16 DHTKD1 RPS19 RPL18A RPL36AL KYNU RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 80%1253288 Downregulation of ERBB4 signaling WWP1 RPS27A ITCH UBB UBA52 NEDD4 SRC UBC GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 80%1660662 Glycosphingolipid metabolism ENPP7 ESYT3 ESYT2 ARSA SUMF2 SUMF1 ESYT1 CPTP GBA ASAH1 ASAH2 NEU2 UGCG UGT8 NEU3 ARSL ARSJ NEU1 ARSK PSAP ARSH ARSI ARSF B4GALNT1 ARSG GLTP ARSD CERK ARSB HEXB CTSA HEXA B3GALNT1 GBA3 GBA2 SMPD3 SMPD2 GALC STS SMPD4 GM2A GLB1L GLB1 SMPD1 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 80%9034013 NTF3 activates NTRK3 signaling NTRK3 NTF3 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.2 Activation of BIM and translocation to mitochondria MAPK8 DYNLL1 BCL2L11 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 80%111461 Cytochrome c-mediated apoptotic response APIP MAPK1 MAPK3 CASP9 UACA CYCS CASP3 XIAP CASP7 DIABLO CARD8 APAF1 AVEN CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 80%5607763 CLEC7A (Dectin-1) induces NFAT activation PPP3CA ITPR1 ITPR2 PPP3CB ITPR3 NFATC3 NFATC2 PPP3R1 NFATC1 AHCYL1 CALM1 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 80%5655862 Translesion synthesis by POLK RPA3 RPS27A REV1 MAD2L2 REV3L UBA52 PCNA RPA1 POLK RFC5 RFC3 RFC4 UBB RFC1 RFC2 RPA2 UBC ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-HSA-1592389.2 Activation of Matrix Metalloproteinases ELANE KLKB1 COL18A1 CTSV MMP25 MMP24 CTSK TIMP2 PRSS1 CTSG TIMP1 TPSAB1 MMP7 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 PRSS2 MMP11 MMP14 CTRB2 MMP13 MMP16 CTRB1 MMP15 MMP17 PLG FURIN SPOCK3 KLK2 CMA1 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.2 L1CAM interactions RPS6KA2 RPS6KA1 SCN9A SH3GL2 SPTBN2 SCN8A DLG1 SPTA1 DLG3 DLG4 CNTN1 MAPK1 CNTN2 MAPK3 SCN5A SCN4A CSNK2A1 SCN4B CSNK2A2 ITGB1 LAMA1 CSNK2B RANBP9 SCN7A DPYSL2 CLTC PAK1 NRCAM CLTA RAC1 EGFR ALCAM SCN11A L1CAM NCAN VAV2 SDCBP MAP2K1 LYPLA2 SCN10A DNM1 DNM2 DNM3 GAP43 RDX DCX NUMB NCAM1 LAMC1 SPTBN1 CNTNAP1 ITGAV SPTAN1 SPTB ITGA5 ITGA9 HSPA8 NRP1 CHL1 CNTN6 ITGA2 ITGA10 ITGA1 ANK1 EPHB2 LAMB1 SCN1B SCN1A ANK2 ANK3 SHTN1 KCNQ2 KCNQ3 SCN3B SCN3A KIF4B NFASC KIF4A RPS6KA4 CD24 RPS6KA6 SCN2A SCN2B NRP2 MSN AP2S1 AP2A1 AP2B1 AP2A2 AP2M1 ITGB3 ITGA2B EZR SPTBN4 MAP2K2 SPTBN5 RPS6KA3 RPS6KA5 MATURATION OF PROTEIN E%REACTOME%R-HSA-9694493.1 Maturation of protein E RPS27A UBB UBA52 UBC DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.2 Defects in biotin (Btn) metabolism MCCC1 PCCB ACACA PC MCCC2 BTD PCCA HLCS TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 80%6803211 TP53 Regulates Transcription of Death Receptors and Ligands TP63 TNFRSF10B TP73 FAS TNFRSF10A TNFRSF10D TP53BP2 PPP1R13B IGFBP3 TNFRSF10C TP53 TMEM219 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 80%212718 EGFR interacts with phospholipase C-gamma PLCG1 EPGN BTC AREG EGF HBEGF EREG TGFA EGFR INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.2 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 OVGP1 ZP1 ZP3 ZP2 B4GALT1 SPAM1 ZP4 ADAM21 ADAM30 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 80%9674403 Regorafenib-resistant PDGFR mutants PDGFRA DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 80%5693532 DNA Double-Strand Break Repair HERC2 PRKDC SUMO2 RAD51B RAD51C PIAS4 PARP1 RAD1 NHEJ1 TDP2 RNF168 TDP1 DCLRE1C CDK2 RIF1 BLM MRE11 WRN POLL POLM XRCC4 CHEK2 SEM1 UBE2N RAD9B RAD9A RPA1 ATM UBXN1 RAD52 BABAM1 TOPBP1 BABAM2 UIMC1 BAZ1B FEN1 ABRAXAS1 RNF8 BRCC3 APBB1 TP53BP1 KDM4A EYA1 EYA2 EYA3 EYA4 UBE2V2 PPP5C CCNA2 BAP1 SIRT6 CCNA1 DNA2 XRCC6 XRCC5 RTEL1 POLQ NSD2 H3-4 CHEK1 LIG4 RNF4 PCNA POLD3 POLD4 POLD1 POLD2 POLK POLE RFC5 RFC3 CLSPN RFC4 RFC1 TP53 RFC2 RPA2 XRCC1 LIG3 MAPK8 POLE4 KPNA2 RPA3 MUS81 POLE2 EME1 POLE3 EME2 POLH GEN1 SLX1B SPIDR SLX4 XRCC3 BRCA2 RAD51AP1 BRIP1 KAT5 UBE2I EXO1 SUMO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51D KDM4B RAD50 RAD51 H2AX H2BC12L PPP4R2 TIPIN UBA52 H2BC21 TIMELESS PPP4C H2BU1 PAXIP1 ABL1 H2BC17 H2BC12 H2BC13 H2BC14 HUS1 H2BC15 H2BC11 UBB UBC RHNO1 H2BC9 RPS27A PARP2 ATRIP H4C9 H2BC8 H2BC5 RAD17 H2BC3 SMARCA5 ATR H2BC1 ERCC4 ERCC1 MDC1 BRCA1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 80%8957322 Metabolism of steroids HELZ2 ARV1 SUMO2 STARD3NL HSD17B3 PIAS4 HSD17B7 HSD17B2 SLCO1B1 MSMO1 SLCO1B3 ABCC3 IDI1 IDI2 EBP HSD17B1 FDPS CYP17A1 CYP19A1 LGMN SLCO1A2 LSS MVK SEC23A CHD9 SEC24B SEC24A SEC24D RXRA SEC24C TBL1XR1 SLC27A2 LRP2 TBL1X LDLRAP1 CUBN OSBPL1A LBR SAR1B MED1 CYP11A1 FDX1 FDX2 FDXR HSD3B2 CYP11B2 CYP21A2 HSD3B1 PPARA TSPOAP1 SCD OSBP MBTPS1 CYP11B1 ALB CREBBP MBTPS2 GPAM OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 CH25H LHB CGA NCOA2 FABP6 RAN KPNB1 MVD ACACB ACACA CYP46A1 CYP39A1 UBE2I SP1 MTF1 NFYA NFYB NSDHL NFYC STARD3 STARD4 TGS1 STARD6 SREBF1 VDR HSD11B1 HSD11B2 FDFT1 SQLE SMARCD3 CARM1 SERPINA6 TSPO STARD5 FASN SLC10A1 ELOVL6 SLC10A2 PTGIS SLC51A CYP8B1 SLC51B SC5D GC TM7SF2 POMC INSIG2 INSIG1 HSD3B7 CYP51A1 ACAT2 AKR1C1 PMVK AKR1D1 AKR1C3 SRD5A2 NR1H4 SRD5A1 AKR1C2 DHCR24 AKR1C4 ACOT8 CYP7B1 DHCR7 ABCB11 BAAT CYP7A1 CYP27A1 AKR1B1 GGPS1 AMACR HMGCS1 CYP27B1 NCOA1 ACOX2 HSD17B4 SLC27A5 HSD17B14 NCOA6 HSD17B12 CYP24A1 CYP2R1 HSD17B11 SREBF2 PLPP6 SCAP SRD5A3 STAR AKR1B15 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 80%5652084 Fructose metabolism ALDOB TKFC ALDH1A1 SORD AKR1B1 KHK GLYCTK HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 80%70921 Histidine catabolism HAL AMDHD1 HDC CARNMT1 HNMT UROC1 CARNS1 FTCD PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.2 Phospholipase C-mediated cascade: FGFR1 FGF22 FGF10 PLCG1 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.2 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNH2 KCNE5 AKAP9 KCNQ1 KCNE1 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 80%9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CA SOS1 HRAS STAT3 PIK3CB PIK3R2 PDGFRA STAT1 PIK3R1 NRAS METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 80%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS1 TXNRD1 PAPSS2 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.3 Signaling by AXIN mutants PPP2CA PPP2CB AMER1 CSNK1A1 PPP2R1A PPP2R5D PPP2R1B PPP2R5E GSK3B APC AXIN1 PPP2R5B PPP2R5A PPP2R5C MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.5 Mitochondrial Fatty Acid Beta-Oxidation MECR ACOT7 ACOT1 ACADL MCAT NDUFAB1 ACAA2 MCEE ACOT7L ACOT11 ACOT12 ACOT13 ACBD7 ECHS1 ACBD6 ACADM HADH MMAA ACSF2 DBI MMUT PCTP THEM5 THEM4 ACOT2 ACSM3 ACSM6 ACADS PCCA ACADVL PCCB ECI1 HADHB ACAD11 HADHA ACAD10 DECR1 ACOT9 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 80%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) CYBB ITGB5 ITGAV CYBA NCF1 CD36 NCF2 NCF4 SIGNALING BY NTRK3 (TRKC)%REACTOME%R-HSA-9034015.2 Signaling by NTRK3 (TRKC) IRS1 NELFB PIK3R1 SRC NRAS PIK3CA PLCG1 PTPRO SOS1 NTRK3 HRAS NTF3 PTPRS BAX DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.2 Defective RIPK1-mediated regulated necrosis TRADD TRAF2 CASP8 RIPK1 FADD ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.2 Acyl chain remodelling of PI PLA2G4F PLA2G2F PLA2G12A PLA2G5 PLA2G2D PLA2G4D PLA2G2E PLA2G4E PLA2G4C MBOAT7 PLA2G4A PLA2G2A PLAAT3 PLA2G10 PLA2G1B PLBD1 PLA2R1 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 80%9031628 NGF-stimulated transcription NAB1 TPH1 NAB2 ATF1 CDK5R1 FOSB ID1 TCF12 EGR1 SH3GL3 ARC F3 TRIB1 RRAD EGR3 EGR4 FOSL1 ID2 ID4 EP300 JUNB ID3 ELK1 LYL1 CREB1 ASCL1 CDK5R2 EGR2 FOS CDK5 VGF SRF CHD4 DNM2 JUND REST ATF2 SGK1 MEF2D NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 80%447038 NrCAM interactions CNTN2 NRCAM ANK1 NRP2 DLG1 DLG3 DLG4 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.9 ROS and RNS production in phagocytes ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 NOS2 NOS3 CYBB CYBA HVCN1 MPO RAC2 LPO ATP6V1H ATP6V1A TCIRG1 ATP6V0A2 ATP6V0A4 ATP6V1E1 ATP6V0E2 ATP6V1G3 NOS1 ATP6V1E2 ATP6V1D ATP6V1C1 ATP6V0A1 NCF1 ATP6V1F ATP6V1C2 NCF2 ATP6V1G1 ATP6V0B NCF4 ATP6V0E1 ATP6V1G2 SLC11A1 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.3 RHOBTB3 ATPase cycle RAB9A VHL RAB9B CUL3 PLIN3 CCNE1 RHOBTB3 HGS LRRC41 TBC RABGAPS%REACTOME%R-HSA-8854214.1 TBC RABGAPs TBC1D3 TBC1D7 RAB11B ARF6 GGA2 RAB4A GGA1 GGA3 OPTN RABGEF1 TBC1D10A TBC1D20 TBC1D24 TBC1D10B TBC1D25 RAB35 GABARAPL2 TSC2 RAB6B SYTL1 TSC1 RAB7A TBC1D13 TBC1D14 GABARAP ULK1 RAB5A TBC1D17 TBC1D15 TBC1D16 RAB11A MAP1LC3B TBC1D10C RAB8A RAB5B RAB5C RAB8B RAB33A RAB33B RAB6A TBC1D2 RAB7B RABGAP1 RABEP1 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME DATABASE ID RELEASE 80%2142850 Hyaluronan biosynthesis and export HAS2 ABCC5 CEMIP HAS1 HAS3 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 80%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME%R-HSA-1368071.3 NR1D1 (REV-ERBA) represses gene expression NCOR1 NR1D1 HDAC3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 80%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes CTSL SOCS3 CTSK CBFB SERPINB13 SOCS4 CTSV RUNX1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.3 Post NMDA receptor activation events RPS6KA2 RPS6KA1 ADCY1 ADCY8 CAMK2B PRKAA1 GRIA1 PRKAA2 GRIA2 CAMK2D ACTN2 PRKAG1 SRC PRKAG2 CAMK2A PRKAG3 NRG1 GRIN2C GRIN2B GRIN1 NRGN PRKX CAMKK1 GRIN2D CAMKK2 GRIN2A DLG1 DLG2 DLG3 LRRC7 PRKAB2 DLG4 NEFL CALM1 CAMK2G PRKAB1 KPNA2 MAPK1 MAPK3 PRKACA CAMK4 PDPK1 RAC1 GIT1 NRAS RASGRF2 HRAS CREB1 PRKAR2B RASGRF1 PRKACG PRKACB RPS6KA6 PRKAR1B PRKAR1A CAMK1 PRKAR2A RPS6KA3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 80%69275 G2 M Transition PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 FBXL7 PSME1 PSME2 PSMD10 CDK2 PSMB11 CENPF WEE1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PPP2CA PPP2CB PPP2R2A PSMB10 PPME1 PSMA8 PHLDA1 PSMB6 GTSE1 PSMB7 FKBPL PSMB4 TUBGCP2 PSMB5 HMMR PSMB2 PKMYT1 PSMB3 TUBGCP5 PSMB1 PSMF1 TUBGCP6 TUBGCP3 TUBGCP4 PSMB8 LIN54 PSMB9 CDC25C FOXM1 SEM1 MYBL2 LIN52 PSMC5 TUBG2 PSMC6 MZT2B PSMC3 MZT2A PSMC4 NME7 PSMC1 LIN37 PSMC2 LIN9 LCMT1 CDK11A PPP2R3B CDK11B MZT1 CCNA2 CCNA1 CDC25A FBXL18 EP300 TP53 CEP57 YWHAE XPO1 CETN2 CEP164 CCP110 PPP1CB ACTR1A PCM1 TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG PPP2R1B CDK5RAP2 SKP1 OFD1 HSP90AA1 CEP135 PPP1R12A BORA FBXW11 TUBB CEP131 HAUS4 HAUS3 HAUS6 CSNK1D HSP90AB1 HAUS5 CCNH CSNK1E TUBG1 CDC25B DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 UBA52 SFI1 AJUBA OPTN SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 RBBP4 UBC CEP72 CEP192 CDK7 MNAT1 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 TPX2 NDE1 CEP152 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 RBX1 CDKN1A APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 80%75153 Apoptotic execution phase PKP1 H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 OCLN LMNB1 CASP3 DFFB DFFA PRKCQ GAS2 MAPT SATB1 PTK2 TJP1 CLSPN GSN BMX STK24 STK26 HMGB2 DNM1L PLEC ADD1 SPTAN1 ACIN1 CTNNB1 DSG3 KPNB1 KPNA1 APC ROCK1 CASP6 VIM DSP HMGB1 BCAP31 CASP8 PAK2 DSG1 CASP7 PRKCD CDH1 DSG2 FNTA DBNL BIRC2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 80%170968 Frs2-mediated activation MAPK1 NGF CRKL MAPK3 FRS2 RAP1A MAP2K2 YWHAB RAPGEF1 MAP2K1 BRAF SMAC (DIABLO) BINDS TO IAPS%REACTOME%R-HSA-111463.3 SMAC (DIABLO) binds to IAPs CYCS CASP3 XIAP CASP7 DIABLO CASP9 APAF1 CD28 CO-STIMULATION%REACTOME%R-HSA-389356.3 CD28 co-stimulation CD86 CDC42 PAK1 TRIB3 PDPK1 LCK MAPKAP1 CD80 CD28 MAP3K14 FYN RAC1 AKT3 PAK3 PIK3R3 PAK2 PIK3R1 VAV1 PIK3CA AKT2 MLST8 GRAP2 AKT1 RICTOR MAP3K8 MTOR YES1 PIK3R2 LYN THEM4 PRR5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 80%1839130 Signaling by activated point mutants of FGFR3 FGF1 FGF16 FGF2 FGF18 FGF4 FGFR3 FGF9 FGF20 FGF23 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME%R-HSA-69610.4 p53-Independent DNA Damage Response PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 CHEK2 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 UBB UBC RPS27A CHEK1 CDC25A PHOSPHORYLATION OF PROTEINS INVOLVED IN THE G2 M TRANSITION BY CYCLIN A:CDC2 COMPLEXES%REACTOME DATABASE ID RELEASE 80%170145 Phosphorylation of proteins involved in the G2 M transition by Cyclin A:Cdc2 complexes CDK1 CCNA2 CCNA1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.2 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ARHGAP35 RASA1 RHOA ELMO2 RAC1 DOCK1 NRAS CRK HRAS PXN PTK6 ELMO1 BCAR1 PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.2 Platelet sensitization by LDL PPP2CA PECAM1 PPP2CB PTPN6 PPP2R1A LRP8 PLA2G4A PPP2R5D PPP2R1B PPP2R5E PTPN11 MAPK14 PPP2R5B PPP2R5A PPP2R5C FGR APOB APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 80%174143 APC C-mediated degradation of cell cycle proteins ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 SKP2 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 CDK2 ANAPC4 PSMB11 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NEK2 AURKB PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 FBXO5 PTTG1 CCNA2 CCNA1 UBA52 CUL1 AURKA CCNB1 UBB UBC RPS27A BUB1B CDC20 BUB3 MAD2L1 PLK1 CDK1 RB1 UBE2D1 ANAPC15 CDC14A ANAPC16 ANAPC10 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.2 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 80%418038 Nucleotide-like (purinergic) receptors P2RY12 P2RY13 P2RY10 P2RY14 ADORA2A ADORA2B LPAR4 ADORA3 ADORA1 GPR17 P2RY11 LPAR6 P2RY6 P2RY4 P2RY2 P2RY1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 80%186712 Regulation of beta-cell development FOXA2 PDX1 HNF1A RFX6 AKT3 PAX4 CREBBP PAX6 NOTCH1 MAML2 ONECUT3 MAML1 ONECUT1 HNF1B RBPJ KAT2B AKT2 KAT2A SNW1 EP300 AKT1 HES1 MAML3 MAMLD1 NEUROG3 FGF10 INSM1 FOXO1 HNF4G IAPP SLC2A2 NEUROD1 NKX6-1 INS NKX2-2 MAFA GCK PTF1A FOXA3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 80%416476 G alpha (q) signalling events PRKCQ RASGRP2 RASGRP1 AVP TBXA2R FFAR3 FFAR2 PLCB3 PLCB4 PLCB1 PLCB2 GAST HBEGF RGS5 RGS2 RGS3 RGS1 CHRM3 CHRM1 RGS18 CHRM5 RGS13 HTR2B RGS21 HTR2C ADRA1D HTR2A ADRA1B ADRA1A HRH1 MGLL XCL2 XCL1 PRKCE ITPR1 ITPR2 ITPR3 XCR1 GPR143 GRK2 TRPC7 TRPC6 TRPC3 APP NPFFR2 NPFFR1 PRKCD GRPR EDNRA ANXA1 EDNRB MT-RNR2 PROK2 PROK1 FPR2 OXTR UTS2R AVPR1B NPFF OXT AVPR1A TRHR UTS2B PTGFR LPAR1 LPAR2 LPAR3 LPAR4 DGKG DGKE CYSLTR1 DGKD HCRT DGKB NTSR1 DGKA NTSR2 DGKZ GPR17 DGKQ NMB DGKK NMBR SAA1 DGKI LPAR5 DGKH LPAR6 NMS NMU GNRH2 RPS6KA3 GNRH1 RPS6KA2 RPS6KA1 QRFP PRKCA MLN BRS3 GPR132 CCKAR GNRHR EDN1 GPRC6A EDN2 EDN3 GRM5 TACR2 TACR3 CCKBR RGS17 RGS19 RGSL1 RGS16 PTGER1 RGS4 PRKCH CASR PROKR1 PROKR2 KISS1R P2RY10 MAPK1 PTAFR MAPK3 GPR4 AGT F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR LTB4R2 ABHD12 DAGLA TRIO UTS2 ABHD6 DAGLB NTS MCHR2 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R PIK3R1 BDKRB2 BDKRB1 EGFR NRAS QRFPR PIK3CA GNRHR2 SOS1 HRAS P2RY6 P2RY2 P2RY1 CCK PIK3R2 HCRTR2 HCRTR1 KISS1 BTK PIK3R3 KALRN CYSLTR2 GRP FFAR4 FFAR1 MMP3 GRK5 GNG10 GNG12 GNG11 GNG13 GNAQ GNB2 MAPK7 GNB1 GNB4 GNB3 GPR39 GNB5 KNG1 GNGT1 GNGT2 F2R NPSR1 F2 GNA14 NPS GNA15 P2RY11 GNG3 GCG CREB1 GNG2 GNG5 GNG4 GNA11 GNG7 GNG8 AGTR1 MCHR1 ARHGEF25 TACR1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 80%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 80%9022534 Loss of MECP2 binding ability to 5hmC-DNA TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.3 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP4A CHMP6 CHMP7 PIK3C3 PIK3R4 BECN1 MAP1LC3B CHMP2B CHMP4C CHMP2A UVRAG CHMP4B CHMP3 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.2 Formation of the HIV-1 Early Elongation Complex CCNH POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 CTDP1 SUPT4H1 GTF2H2 NELFB GTF2H3 NELFCD GTF2H4 NELFA NCBP1 GTF2H5 NELFE NCBP2 SUPT5H ERCC3 ERCC2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 80%426117 Cation-coupled Chloride cotransporters SLC12A3 SLC12A4 SLC12A5 SLC12A1 SLC12A6 SLC12A7 SLC12A2 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.2 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.2 HHAT G278V doesn't palmitoylate Hh-Np IHH DHH SHH HHAT ATTENUATION PHASE%REACTOME%R-HSA-3371568.1 Attenuation phase DNAJB1 HSP90AB1 HSF1 HSPA1L HSPA1B HSPA1A CREBBP PTGES3 HSPA2 HSPA8 HSP90AA1 HSBP1 EP300 FKBP4 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.1 Reverse Transcription of HIV RNA PPIA SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 80%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III TUBA1B CHMP4A CHMP6 CHMP7 TUBA4A TUBB2B TUBB2A TUBAL3 TUBA3E TUBB6 TUBA3D TUBB3 TUBB1 TUBA3C SPAST CC2D1B LEMD2 TUBA4B TUBB8 TUBA1A TUBB8B TUBB4B TUBB4A VPS4A IST1 CHMP2B CHMP4C TUBA8 CHMP2A CHMP4B TUBA1C CHMP3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.2 Inactivation, recovery and regulation of the phototransduction cascade PRKCA SAG NMT1 GUCA1B GRK1 GUCA1A GUCY2D GUCA1C GRK7 PRKCQ GUCY2F CALM1 CNGB1 RHO RCVRN PPEF1 METAP1 METAP2 FNTA FNTB GNAT1 GNB1 PDE6B PDE6A NMT2 PDE6G CAMKMT RGS9BP GNGT1 CNGA1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 80%2142688 Synthesis of 5-eicosatetraenoic acids GPX1 GPX4 PON3 ALOX5AP PON1 LTC4S GPX2 PON2 ALOX5 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME DATABASE ID RELEASE 80%3928665 EPH-ephrin mediated repulsion of cells EPHB3 EPHA5 EPHA4 EPHA7 CLTC EPHA6 EPHA8 CLTA FYN RAC1 EPHA1 EPHA3 EPHA10 CLTCL1 EFNA5 EFNA4 VAV2 EFNB2 TIAM1 VAV3 EFNB1 EFNB3 MMP2 EFNA1 EFNA3 EPHA2 MMP9 YES1 EFNA2 LYN APH1A PSENEN APH1B PSEN2 AP2S1 ADAM10 AP2A1 AP2B1 AP2A2 AP2M1 DNM1 PSEN1 EPHB6 EPHB2 EPHB1 NCSTN CLTB EPHB4 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 80%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME DATABASE ID RELEASE 80%9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane HMOX1 SERP1 SEC61G UBL4A SEC61B GET1 EMD GET3 BAG6 SGTA STX1A GET4 CAMLG STX5 VAMP2 OTOF VAPA APP PRNP TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.2 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 RBL2 RBL1 HDAC1 E2F4 E2F5 CCNA2 E2F1 LIN54 MYBL2 TFDP1 CDK1 LIN52 TFDP2 LIN37 LIN9 RBBP4 CHAPERONE MEDIATED AUTOPHAGY%REACTOME%R-HSA-9613829.3 Chaperone Mediated Autophagy HSP90AB1 RPS27A PARK7 PCNT IFT88 CFTR PLIN3 PLIN2 RNASE1 UBA52 HSPA8 HBB GFAP ARL13B LAMP2 CETN1 EEF1A1 HSP90AA1 UBB HDAC6 UBC DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.2 Defective TBXAS1 causes GHDD TBXAS1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.5 Translocation of ZAP-70 to Immunological synapse HLA-DPB1 LCK HLA-DQA2 HLA-DQA1 HLA-DRB5 HLA-DRB4 TRBC1 HLA-DQB2 HLA-DQB1 TRBV12-3 TRBV7-9 TRAV19 HLA-DRB3 HLA-DRB1 HLA-DRA ZAP70 CD3G TRAC CD3E CD3D CD4 TRAV8-4 HLA-DPA1 PTPN22 TRAV29DV5 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 80%8963693 Aspartate and asparagine metabolism ASNS FOLH1 GOT2 ASPG ASPA FOLH1B GOT1 SLC25A12 NAALAD2 GADL1 NAT8L SLC25A13 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.2 Netrin-1 signaling SIAH2 SIAH1 DOCK1 SRC PRKCQ ROBO1 PTK2 MAPK14 WASL MAPK8 NEO1 NTN4 NTN1 MYO10 TRPC7 TRPC5 TRIO TRPC6 TRPC3 SLIT1 MAPK11 TRPC4 TRPC1 SLIT3 SLIT2 CDC42 UNC5A PAK1 UNC5B UNC5C UNC5D RAC1 MAPK12 DSCAM AGAP2 MAPK13 PLCG1 ABLIM1 ABLIM2 ABLIM3 PITPNA NCK1 HJV DCC RGMB RGMA DSCAML1 EZR PTPN11 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 80%9013404 RAC2 GTPase cycle MPP7 VANGL1 CDC42EP4 ARHGAP32 DIAPH3 TAOK3 ABI2 ABI1 ESYT1 PIK3R3 DOCK2 DOCK1 DEF6 VAV3 RAC2 LAMTOR1 ARMCX3 ITGB1 NCKAP1 CYFIP1 TRIO NCF1 TFRC NCF2 NCF4 ARHGAP1 VAPB BRK1 ARHGAP39 SAMM50 ARHGAP35 CDC42 ANKLE2 DOCK10 PAK1 SYDE1 PREX1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 PLD2 PAK2 MTX1 VAV1 PIK3R1 EMD LBR GIT1 TMPO PIK3CA SWAP70 CYBB CYBA VRK2 LEMD3 VAV2 BCR TIAM1 DEPDC1B CDC42EP1 DSG2 RAB7A EPHA2 VAMP3 ARHGDIA GARRE1 IQGAP1 PIK3R2 ARHGAP17 ERBIN DOCK4 DOCK3 LMAN1 ABR ARHGAP21 PGRMC2 RACGAP1 NHS SLITRK5 NCKAP1L WASF2 PAK4 GIT2 CAV1 MCAM MCF2 ARHGAP26 ABACAVIR ADME%REACTOME%R-HSA-2161522.3 Abacavir ADME SLC22A3 ABCB1 GUK1 ABCG2 ADH1A SLC22A2 ADAL SLC22A1 PCK1 NT5C2 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.4 Clearance of seratonin SLC6A4 MAOA ALDH2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 80%112040 G-protein mediated events PRKCG ADCY3 PRKCA ADCY2 ADCY1 ADCY8 PDE1C PDE1B ADCY7 PDE1A ADCY6 ITPR1 ADCY5 ITPR2 CAMK2B ITPR3 CAMK2D CAMK2A GNAT3 PRKX CAMKK1 CAMKK2 CALM1 CAMK2G KPNA2 GNAL MAPK1 GRK2 NBEA PRKACA GNAQ PLCB3 PLCB4 PLCB1 PLCB2 CAMK4 GNAI3 GNAI1 GNAI2 GNA14 PRKCD GNA15 CREB1 GNA11 PRKAR2B PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PLA2G4A PRKAR2A AHCYL1 ADCY4 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 80%8875791 MET activates STAT3 STAT3 HGF MET RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 80%3214858 RMTs methylate histone arginines CCND1 H2AW H2AC17 H2AC12 H2AC1 H3C15 H2AC21 PRMT6 CDK4 PRMT7 RPS2 PRMT5 WDR77 COPRS WDR5 PRMT1 ACTL6A DNMT3A H2AX H2AB1 H2AC19 H2AC14 SMARCD1 SMARCD2 SMARCB1 ARID2 SMARCD3 H2AC8 CARM1 H2AC6 SMARCE1 SMARCC1 H2AC7 PBRM1 SMARCC2 ACTL6B ARID1A H2AJ SMARCA2 ARID1B RBBP7 H2AZ1 SMARCA4 H2AZ2 PRMT3 H4C9 H2AC20 H3C8 JAK2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.1 SARS-CoV-2 Genome Replication and Transcription VHL DDX5 ZCRB1 RB1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 80%1362277 Transcription of E2F targets under negative control by DREAM complex RBL2 RBL1 HDAC1 MYC MAX E2F4 E2F5 E2F1 TOP2A CDC25A LIN54 PCNA TFDP1 LIN52 TFDP2 LIN37 LIN9 CDC6 RBBP4 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.2 Defective GNE causes sialuria, NK and IBM2 GNE NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 80%9734207 Nucleotide salvage defects APRT HPRT1 ADA RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 80%5693537 Resolution of D-Loop Structures RAD50 RAD51 RAD51B RAD51C DNA2 RTEL1 BLM MRE11 WRN MUS81 EME1 EME2 GEN1 SLX1B SPIDR SLX4 XRCC3 SEM1 BRCA2 RAD51AP1 BRIP1 KAT5 EXO1 ATM RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A BRCA1 PALB2 RAD51D REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 80%6804758 Regulation of TP53 Activity through Acetylation PIP4K2C BRD7 HDAC1 AKT3 MAP2K6 HDAC2 AKT2 EP300 AKT1 MBD3 GATAD2B GATAD2A KAT6A TP53 RBBP4 RBBP7 MEAF6 BRPF1 BRPF3 CHD4 CHD3 ING5 ING2 PIP4P1 PIN1 MTA2 PML BRD1 PIP4K2A PIP4K2B SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 80%8852405 Signaling by MST1 MST1R MST1 SPINT1 HPN SPINT2 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 80%69560 Transcriptional activation of p53 responsive genes ZNF385A PCBP4 CDKN1A TP53 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 80%196071 Metabolism of steroid hormones STARD6 STARD3NL HSD17B3 CYP11B1 HSD11B1 HSD11B2 HSD17B2 SERPINA6 TSPO HSD17B1 CYP17A1 CYP19A1 POMC LHB CYP11A1 FDX1 FDX2 FDXR SRD5A2 SRD5A1 HSD3B2 CYP11B2 CGA CYP21A2 HSD3B1 AKR1B1 HSD17B14 HSD17B12 HSD17B11 TSPOAP1 SRD5A3 STARD3 STAR STARD4 AKR1B15 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 80%888590 GABA synthesis, release, reuptake and degradation RAB3A SLC32A1 ALDH5A1 SLC6A13 ABAT SYT1 SLC6A12 HSPA8 SLC6A11 CPLX1 SNAP25 SLC6A1 STX1A DNAJC5 RIMS1 GAD1 VAMP2 GAD2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 80%372790 Signaling by GPCR CCL19 CCL22 CCL20 CAMK2B CAMK2D SRC CAMK2A CALM1 CAMK2G AVP TBXA2R FFAR3 GPR31 FFAR2 ROCK1 PLEKHG5 UCN PIK3R6 HBEGF OPRD1 CXCR1 PLA2G4A CXCR2 MGLL AHCYL1 C5AR2 C5AR1 PRKCE PDE1C AKT3 CXCL8 CXCL1 PRKX CXCL2 CAMKK1 CAMKK2 OPRM1 VAV3 S1PR1 KPNA2 GRK2 PPP2R1A NBEA PRKACA TRPC7 TRPC6 TRPC3 ITSN1 PRKCD HEBP1 ANXA1 MT-RNR2 FPR1 FPR3 FPR2 PRKAR2B NGEF ARHGEF33 DGKG ARHGEF35 DGKE ARHGEF37 DGKD ARHGEF38 GNAT2 DGKB DGKA DGKZ WNT5A DGKQ DGKK WNT11 DGKI DGKH FZD3 FZD2 FZD5 FZD4 FZD6 RPS6KA3 TAS2R7 RPS6KA2 TAS2R60 PRKCG RPS6KA1 TAS2R40 PRKCA TAS2R9 TAS2R41 TAS2R8 TAS2R20 TAS2R42 TAS2R43 TAS2R45 C3AR1 FGD1 TAS2R46 FGD2 GRM3 GPRC6A FGD3 FGD4 GRM2 PRKCB GRM5 GRM4 GRM7 GRM6 GRM8 TAS2R1 RGS17 TAS1R2 AKT2 RGS19 TAS1R1 RGSL1 TAS2R3 RGS16 TAS1R3 AKT1 RGS4 TAS2R5 TAS2R4 RGS20 PRKCH TAS2R50 CASR TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R38 TAS2R16 TAS2R39 TAS2R19 PTAFR OBSCN ITGB1 TRIO WNT2B WNT8A WNT8B CAMK4 PREX1 WNT6 WNT2 DHH PIK3R1 WNT3 PLXNB1 WNT4 EGFR WNT10A NRAS PIK3CA WNT3A WNT7B WNT9B RASGRF2 SOS1 WNT7A HRAS WNT9A WNT16 VAV2 TIAM1 PLEKHG2 PIK3R2 SOS2 ROCK2 GABBR2 ABR GABBR1 FZD1 FZD8 MCF2 TIAM2 SST BTK PIK3R3 SHH KALRN IHH GRP NET1 FFAR4 FFAR1 AKAP13 MMP3 CXCL12 PPBP ITGA5 RHOC RHOB PPP2R5D ARHGEF9 PPP3CA ARHGEF3 MAPK7 PPP2R1B ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 KNG1 ARHGEF5 ARHGEF6 F2R F2 PENK SSTR3 PF4 ARHGEF40 AGTR1 MCHR1 RHO PPP3CB ADGRE5 ARHGEF26 ADGRE3 ARHGEF25 GNA12 ECT2 NPY ARHGEF39 TACR1 ARHGEF10L MCF2L PRKCQ ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 RASGRP2 ARHGEF19 RASGRP1 ARHGEF18 WNT1 PPP1R1B PDE4B GNA13 FZD10 CRHBP FZD9 UCN3 UCN2 PTCH2 ADGRE1 ADGRE2 PLCB3 PLCB4 PLCB1 PLCB2 PDPK1 GAST CCL4L2 RGS5 RGS2 RGS3 PRKACG RGS1 PRKACB RGS8 PCP2 GPSM1 CHRM2 GPSM2 ADCY9 CHRM3 GPSM3 CHRM1 SMO RGS18 PRKAR1B CHRM4 RGS14 PRKAR1A CHRM5 RGS13 HTR2B RGS21 HTR2C RGS22 ADRB1 RGS10 ADRA1D RGS12 PRKAR2A ADRB2 HTR2A PTCH1 HTR4 ADRA1B ADRA1A WNT10B TAAR3P CXCL6 HTR6 GNAS CXCL9 CXCL13 HRH1 HTR7 CXCL3 HRH3 CXCL5 CX3CL1 HRH2 CXCL16 HRH4 PTGIR DRD1 CCRL2 DRD2 CCR9 DRD3 CCR8 DRD4 CCR7 DRD5 CCR4 TAAR8 CCR3 ADCY4 HTR1E XCL2 TAAR9 XCL1 ADCY3 HTR1F CX3CR1 TAAR6 CCL13 ADCY2 ADCY1 HTR1D CXCR5 ADCY8 HTR1A CXCR6 TAAR5 ADCY7 CCL7 PDE1B ADCY6 HTR1B PDE1A CXCR3 TAAR2 ADCY5 ITPR1 CCL1 CCL17 ITPR2 ADRA2C CCL16 ITPR3 HTR5A TAAR1 CCR10 CCL25 ADRA2B ADRA2A XCR1 PDE11A CCL21 GPR143 CXCL11 ADRB3 ACKR4 ACKR3 ACKR2 CCL28 CCL27 PDE2A PDE10A GNAL IAPP C3 APP NPFFR2 NPFFR1 RXFP4 RRH GRPR RXFP3 EDNRA EDNRB OXER1 PROK2 PROK1 CMKLR1 OXTR UTS2R AVPR1B NPFF OXT C5 CDK5 GPR37L1 AVPR1A PDYN TRHR UTS2B KEL AGTR2 PTGFR LPAR1 LPAR2 LPAR3 LPAR4 NLN GALR3 GALR2 GALR1 NPBWR1 NPBWR2 CYSLTR1 PPY HCRT NTSR1 NTSR2 GNAT1 GPR17 NMB NMBR SAA1 LPAR5 LPAR6 NMS GPR183 NMU PNOC GNRH2 GNRH1 GPR18 PTGDR2 QRFP MLN BRS3 GPR132 CCKAR OPN1LW GNRHR OXGR1 EDN1 GPR37 EDN2 EDN3 GPR35 TACR2 TACR3 GAL OPN1MW CCKBR RGR NPB PLPPR1 PLPPR2 PTGER1 PLPPR3 PLPPR4 PTGER3 PLPPR5 PROKR1 CXCL10 PROKR2 NPW KISS1R PPP2CA PRLH P2RY12 PPP2CB P2RY13 P2RY10 MAPK1 P2RY14 GPR55 MAPK3 GPR4 AGT CCL5 XK CCL4 F2RL1 CCL3 F2RL2 CCL2 F2RL3 GPR68 GPR65 PMCH NPY2R ADORA3 ADORA1 GHSR CXCR4 NPY1R MTNR1A LTB4R2 ABHD12 MTNR1B DAGLA APLNR UTS2 ABHD6 DAGLB SUCNR1 NTS MCHR2 HCAR2 HCAR3 HCAR1 TAC3 TAC1 OPN4 OPN3 CDC42 OPN5 PAK1 PYY NMUR2 NMUR1 MLNR ECE1 ECE2 TRH PIK3CG PIK3R5 LTB4R VAV1 BDKRB2 BDKRB1 PRLHR CCR1 QRFPR INSL5 NPY5R GNRHR2 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 P2RY6 CNR2 P2RY4 CNR1 P2RY2 P2RY1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 RHOA CCK HCRTR2 HCRTR1 APLN KISS1 OPN1SW CCR6 ACKR1 CCR5 CCR2 VIPR1 VIPR2 SCT RXFP1 RXFP2 GPR176 CYSLTR2 GNAT3 PPP3CC CD55 PDE8B PDE8A PTGDR LHCGR ADCYAP1 GNAZ CALCA ADCYAP1R1 CALCB CALCRL RGS9 GIPR RGS6 LHB RGS7 GPR83 GPR84 CRHR1 CRHR2 GHRHR PPP1CA GRK3 MC2R CALCR GRK5 GRK6 CGA PSAP GPR15 GNG10 MC1R PDE3A RLN2 RLN3 GPR27 GNG12 GNG11 CCL3L3 GLP1R GPR25 GNG13 PDE3B GPR20 GNAQ ADM GNB2 PTH1R MC4R GNB1 GNB4 GPER1 FZD7 PDE4A INSL3 GNB3 TSHB GPR39 GPR32 GNB5 FSHB PDE4D GLP2R AVPR2 GNGT1 PDE4C GPBAR1 PTH2R GNGT2 GIP MC3R ADORA2A ADORA2B FSHR CRH PTGER4 NPSR1 RAMP2 RAMP3 GPR45 PTH PTGER2 GNAI3 PTH2 PTHLH GNAI1 GNAI2 GNA14 NPS GPR150 GPHA2 GNA15 P2RY11 GNG3 SCTR GCG CREB1 GNG2 GNG5 TSHR GNG4 POMC PPP3R1 GHRH GNA11 ADM2 GNG7 MC5R GNG8 PDE7B PDE7A VIP RAMP1 GPHB5 RGS11 ARRB1 ARRB2 CCL11 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.1 Diseases of propionyl-CoA catabolism MMUT MMAA BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.2 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC2 EXOSC1 ZFP36L1 YWHAB DCP1A MAPKAPK2 DIS3 XRN1 DCP2 AKT1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.5 Enzymatic degradation of dopamine by COMT MAOA COMT TOMT ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-HSA-1237044.3 Erythrocytes take up carbon dioxide and release oxygen RHAG SLC4A1 AQP1 CYB5R2 CYB5R1 CA1 CYB5R4 CA2 CA4 HBB HBA2 CYB5RL NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.1 Negative regulation of NMDA receptor-mediated neuronal transmission PPM1E CAMK4 PPM1F CAMK1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN1 GRIN2D GRIN2A DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.4 Selenoamino acid metabolism RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPS6 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A MAT1A RPL3L RPS26 RPS25 NNMT RPS28 RPS27 RPS29 RPL27A PAPSS1 RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 RARS1 KARS1 MARS1 DARS1 AIMP1 AIMP2 SARS1 AHCY EPRS1 TXNRD1 PAPSS2 QARS1 LARS1 IARS1 EEF1E1 INMT SEPHS2 PSTK SECISBP2 EEFSEC SEPSECS CBS CTH SCLY HNMT GNMT UBA52 RPL4 RPS27A RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPS19 RPL18A RPL36AL RPS18 RPL36 RPL35 RPLP2 RPL38 RPL37 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.4 The canonical retinoid cycle in rods (twilight vision) RBP4 NAPEPLD RHO RBP3 RDH5 RBP1 RPE65 DHRS9 SDR9C7 RDH12 RDH11 LRAT HSD17B6 RDH10 STRA6 TTR HSD17B1 RDH16 RDH8 MYO7A ABCA4 CYP4V2 RLBP1 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 80%8953897 Cellular responses to stimuli BMI1 ATP6V1B2 ATP6V0D1 TLN1 ATP6V0C ATP6V0D2 NUP62 NUP214 ATP6V1B1 NDC1 SEC13 KDM6B NUP210 HSPA1B CAMK2B RING1 HSPA1A NUP133 CAMK2D CAMK2A NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 CAMK2G RNF2 POM121C NUP42 NUP85 TPR NUP88 NUP43 RAE1 RANBP2 CBX8 PHC2 PHC1 NUP155 CSNK2A1 CBX4 CDKN2A CSNK2A2 CBX2 RPA1 NUP153 PHC3 HYOU1 CSNK2B NUP35 NUP37 CUL7 PLA2G4B WIPI1 ATF2 ETS1 ETS2 MAP3K5 ERF TNIK TRIB3 ASF1A EP400 GSK3A HSPA5 HMGA2 ID1 HSPA6 CABIN1 AKT3 VENTX MOV10 MINK1 HIRA UBN1 EZH2 MAP4K4 CXCL8 NR3C2 DNAJA1 DNAJA4 DNAJA2 FKBP5 MAP2K4 SUZ12 MAP2K7 JUN FOS RPA2 MAPK9 YWHAE MAPK8 RPA3 MAPK10 EPO AGO3 ACTR1A AGO4 AGO1 CBX6 LY96 BTRC TLR4 EED SKP1 SSR1 KAT5 HSP90AA1 NBN CRTC2 CRTC3 TNRC6C CRTC1 RORA TNRC6A NR3C1 RAD50 TNRC6B BAG4 SLC7A11 DYNLL1 PRDX2 PSPHP1 PRDX1 CLOCK HIF1A SRPRA SRPRB NPAS2 UBA52 ARNTL RAI1 AJUBA NRIP1 NR1D1 DYNC1I2 DCTN2 MT-CO1 PRKCD EHMT1 DCTN3 CUL1 AR DYNC1LI1 DYNC1LI2 COX7A2L SCO1 UBB SCO2 MT-CO2 MT-CO3 UBC RPS27A HSPA9 DYNC1H1 SURF1 SOD2 SOD1 HMOX2 ATR COX7B COX7C EHMT2 COX8A RBX1 MEF2C COX5B DYNLL2 RPS6KA3 COX5A RPS6KA2 PSMD8 RPS6KA1 PSMD9 PSMD6 PSMD7 PSMD4 COX6C PSMD5 PSMD2 LRPPRC PSMD3 PSMD1 SQSTM1 MAP2K6 TXNIP PSMA5 PSMA6 TACO1 PSMA3 PSMA4 RPTOR COX6A1 PSMA1 PSMA2 SESN2 AKT2 PSME3 PSME4 MLST8 PSME1 AKT1 PSME2 SLC38A9 IL1A COX6B1 PSMD10 PSMB11 PSMD12 MAPKAPK5 PSMD11 COX19 PSMD14 RPS6 COX16 PSMD13 COX18 PSMA7 RELA MTOR COX11 PSMB10 GSTP1 PSMA8 COX14 PSMB6 RRAGA PSMB7 RRAGC PSMB4 PSMB5 RHEB PSMB2 RRAGB PSMB3 AKT1S1 PSMB1 RRAGD CALR PSMF1 LAMTOR2 LAMTOR1 NFKB1 PSMB8 LAMTOR4 PSMB9 LAMTOR3 LAMTOR5 CYCS SEM1 PSMC5 PSMC6 CEBPB PSMC3 COX20 PSMC4 PSMC1 PSMC2 COX4I1 RXRA ARNT LMNA NCF1 SZT2 CA9 ATF3 HIGD1A SEH1L NCF2 GPX2 NPRL2 STIP1 NPRL3 NCF4 NCOR2 GCN1 WDR59 HDAC3 NCOR1 ASNS EIF2AK4 TBL1XR1 FLCN MIOS SIN3A ITFG2 IMPACT DEPDC5 TBL1X HSP90B1 KPTN CEBPG NDUFA4 WDR24 SHC1 SH3BP4 TXNRD1 FNIP1 FNIP2 KICS2 CASTOR1 CASTOR2 PPARGC1A BMT2 CYBB CYBA CREB3L4 CREB3L1 CREB3L2 CREBRF HERPUD1 DCSTAMP CREB3 KHSRP PPARA EDEM1 MEF2D MT2A HBA2 HSPB8 HIKESHI CCAR2 HSBP1 DNAJC2 DNAJC7 FKBP4 CRYAB RPS19BP1 HSPA4L HSPA14 HSPA13 HDAC6 DNAJB1 BAG5 XPO1 HSPH1 DNAJB6 BAG2 BAG3 HSF1 BAG1 NCOA2 HSPA1L HSPA4 ST13 HSPA7 PTGES3 HSPA2 HSPA12A HSPA12B PGR MAPK7 SP1 CSRP1 HIF1AN MTF1 SNCB IGFBP1 H2AX H2AB1 H2AC19 PDIA6 DYNC1I1 H2AC14 H2BC12L ACTR10 H2BC21 IGFBP7 H2BU1 WFS1 H2AC8 H2AC6 H2AC7 EPAS1 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RBBP4 RBBP7 H2AZ1 H2BC9 RPL4 RPL5 H2AZ2 RPL30 RPL3 RPL32 H4C9 RPL31 H2BC8 RPL34 RPLP1 RPL10L H2BC5 RPLP0 NCOA1 H2BC3 RPL10A RPL8 H2BC1 CAT RPL6 NCOA6 RPL7 ACADVL FKBP14 H2AC20 MYDGF RPS4X RPS15 TATDN2 TSPYL2 RPL7A DDX11 RPS14 RPS17 PDIA5 RPS16 ERN1 CTDSP2 RPS19 RPL18A DNAJB11 CXXC1 RPL36AL EXTL2 UBE2D2 RPS18 RPL36 EXTL1 RPL35 UBE2D1 DNAJB9 RPLP2 EXTL3 RPL38 ZBTB17 RPL37 KLHDC3 RPS11 YIF1A RPS10 HDGF RPL39 TPP1 RPS13 RPS12 RPS9 PPP1R15A RPL21 GSTA1 HMOX1 RPS7 RPS8 RPS5 RPL23 RPL22 RPL13A RPSA RPS3A RPL9P9 LMNB1 EEF1A1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 MRE11 RPL36A RPS27L ERO1A RPS4Y1 AQP8 RPS15A NUDT2 BACH1 RPL14 RPS3 TXN2 RPL13 SESN1 RPS2 MUL1 PRDX3 RPL15 RPL18 STAP2 CHD9 RPL17 GCLC NPLOC4 RPL19 NOX4 RPL39L RPL41 NOX5 RPL35A GCLM SRXN1 RPL23A MAP1LC3B RPL3L ME1 MAP2K3 RPS26 UBXN7 VHL RPS25 UFD1 RPS28 ABCC1 GPX1 RPS27 GPX3 RPS29 GPX6 RPL27A RPL22L1 GPX5 GPX8 RPS20 GPX7 FAU RPS21 BLVRB ARFGAP1 BLVRA MAPK11 RPL26L1 HM13 RPS24 TXNRD2 RPS23 FBXL17 SOD3 CCS GSTA3 H3-3B TINF2 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP CDKN2D CDKN2B CDKN2C MED1 PREB ACD KDELR3 EIF2S2 EIF2S1 H3-4 EIF2S3 GSK3B MT1M MT1X MT4 MT3 PPP2R5B MT1A EIF2AK1 MT1F NQO1 ATF5 MT1G MT1H HIF3A MT1B HMGA1 MT1E ELOB LIMD1 ELOC EGLN1 EGLN3 EGLN2 WTIP CREBBP NOTCH1 CLEC1B EP300 EIF2AK3 MAPK14 CAPZA3 GRB10 TP53 CUL3 NLRP3 CUL2 IDH1 DIS3 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 TGS1 HSP90AB1 EXOSC2 UBE2D3 EXOSC1 GOSR2 SIRT1 SMARCD3 MAFG MAFK HBB IFNB1 CAPZB RB1 CDKN1A H3C8 ANAPC15 CDKN1B ANAPC16 ANAPC10 ANAPC11 FZR1 HELZ2 SULT1A3 NFE2L2 CDC23 CDC26 CDC27 E2F1 E2F2 E2F3 SKP2 ANAPC7 DNAJC3 UBE2C MAPKAPK3 UBE2E1 MAPKAPK2 H3C15 CDK6 TFDP1 CCNE2 TFDP2 UBE2S CDK4 CCNE1 CDC16 CDK2 ANAPC4 ANAPC5 ANAPC1 CAPZA1 ANAPC2 CAPZA2 ATP7A MYC MAPK1 MAPK3 CCL2 CHAC1 ATOX1 MDM2 MDM4 G6PD ATM TALDO1 PTK6 PGD TKT SEC31A VCP SYVN1 IL6 CREB3L3 APOB CITED2 MBTPS1 APOA1 H1-1 H1-0 ALB H1-3 SERP1 H1-2 H1-5 P4HB H1-4 MBTPS2 SLC46A1 FABP1 ADD1 HSPA8 NFYA NFYB DDIT3 NFYC ATF6 ATF4 DCTN6 DCTN5 DCTN1 DCTN4 CARM1 GFPT1 CREB1 PRDX6 STAT3 ATP6V1H ATP6V1A TCIRG1 KEAP1 ATP6V1E1 ATP6V0E2 ATP6V1G3 ATP6V1E2 ATP6V1D ATP6V1C1 VEGFA ATP6V1F NUP107 TRIM21 ATP6V1C2 ATP6V1G1 NUP188 ATP6V0B ATP6V0E1 ATP6V1G2 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8931987.1 RUNX1 regulates estrogen receptor mediated transcription ESR1 GPAM KCTD6 CBFB AXIN1 RUNX1 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 80%187042 TRKA activation by NGF NTRK1 NGF REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 80%1475029 Reversible hydration of carbon dioxide CA12 CA14 CA13 CA5B CA5A CA9 CA1 CA3 CA2 CA7 CA4 CA6 ONCOGENE INDUCED SENESCENCE%REACTOME%R-HSA-2559585.6 Oncogene Induced Senescence ETS1 TNRC6B ETS2 ERF E2F1 ID1 E2F2 E2F3 MOV10 UBA52 CDKN2D CDKN2B CDK6 CDKN2C TFDP1 TFDP2 CDK4 UBB TP53 UBC RPS27A MAPK1 MAPK3 AGO3 AGO4 AGO1 CDKN2A MDM2 MDM4 SP1 RB1 TNRC6C TNRC6A ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 80%446203 Asparagine N-linked glycosylation COPZ1 ARF5 SEC13 USO1 GRIA1 LMAN2 TRAPPC10 ARCN1 SLC35A1 SLC35C1 SPTA1 B4GALT2 B4GALT3 TRAPPC2 SEC16B TRAPPC3 TRAPPC4 SEC16A B4GALT6 TRAPPC5 B4GALT4 B4GALT5 TRAPPC9 CNIH1 CNIH2 CNIH3 MCFD2 ALG2 PPP6R1 BET1L ARFGAP1 SEC22A ARF3 SEC22C RAB1A DPM1 DPM2 RAB1B PPP6C DPM3 PPP6R3 TRAPPC1 FOLR1 BET1 KDELR1 COL7A1 MANEA CHST10 CHST8 MGAT3 COG8 COG7 COG6 LMAN1L COG5 COG4 COG3 COG2 COG1 PREB ANKRD28 KDELR2 KDELR3 LMAN2L MIA2 PDIA3 TMED3 TMED7 TMED9 NAPB STX17 GMDS FCSK MLEC FPGT FUOM NAPG GFUS SEC23IP COPG2 COPG1 TRAPPC2L TBC1D20 CAPZA3 DERL1 COPB2 COPA TMED10 MAN2A2 COPB1 ACTR1A DOLPP1 MVD DPAGT1 ALG8 TMEM115 ALG9 ALG6 COPE ALG14 ALG13 ALG3 ALG12 MAN1A2 ALG1 MAN1A1 MPDU1 RFT1 TRAPPC6A CSNK1D TRAPPC6B GOLGA2 GORASP1 DYNLL1 GOSR2 GOSR1 UBA52 MAN1C1 NUS1 DYNC1I2 DHDDS DCTN2 DCTN3 ARF1 DYNC1LI1 DYNC1LI2 UBB UBC RPS27A DYNC1H1 CAPZB SPTBN4 SPTBN5 DYNLL2 NSF SPTBN2 STX5 FUCA1 CAPZA1 CAPZA2 SEC22B SEC23A CALR SEC24B SEC24A SEC24D PSMC1 SEC24C UBXN1 PMM1 NUDT14 UAP1 AMDHD2 GFPT2 PGM3 SEC31A NAGK ALG5 VCP SEL1L DERL2 RAD23B SAR1B OS9 SYVN1 TMED2 ENGASE NGLY1 CTSZ ARFGAP3 ARFGAP2 ALG10B ASGR1 ASGR2 LMAN1 CTSC YKT6 ST6GALNAC1 CMAS NPL NANP NEU4 EDEM3 EDEM1 SLC17A5 ST8SIA5 AMFR ST3GAL5 RNF5 ST8SIA6 RNF103 ST3GAL6 RNF139 TRIM13 NANS ST6GAL2 UMOD UGGT2 ST8SIA1 RNF185 ST8SIA3 UGGT1 AREG MARCHF6 ST6GALNAC5 ST6GALNAC6 GNE GNPNAT1 TGFA RENBP CD59 SCFD1 CD55 SPTBN1 FUT3 NEU2 ALG10 LHB NEU3 B4GALNT2 GMPPB GMPPA NEU1 SPTAN1 CGA SPTB CTSA ANK1 GLB1 ST6GALNAC2 RPN2 ARF4 TUSC3 ANK2 DYNC1I1 PRKCSH DCTN6 ANK3 RPN1 DCTN5 DCTN1 MAGT1 ACTR10 DCTN4 GANAB F5 FUT8 MAN2A1 MGAT5 ST3GAL4 NAPA F8 MGAT1 MGAT2 ST3GAL1 GFPT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA4 MIA3 TFG EDEM2 MOGS DDOST MGAT4C ST8SIA2 DAD1 MGAT4A CANX MGAT4B STT3A MAN1B1 ST6GALNAC3 GOLGB1 ST6GALNAC4 GBF1 ALG11 B4GALT1 SERPINA1 INS SRD5A3 COPZ2 MPI PMM2 DOLK REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 80%888593 Reuptake of GABA SLC6A1 SLC6A13 SLC6A12 SLC6A11 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.1 TGFBR2 MSI Frameshift Mutants in Cancer TGFB1 TGFBR2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 80%1839122 Signaling by activated point mutants of FGFR1 FGF1 FGF2 FGF4 FGFR1 FGF6 FGF9 FGF20 FGF23 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 80%203615 eNOS activation ZDHHC21 NOS3 CYGB DDAH1 SPR DDAH2 HSP90AA1 AKT1 CAV1 CALM1 LYPLA1 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 80%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-HSA-1483249.3 Inositol phosphate metabolism PLCB3 PLCB4 PLCB1 PLD4 PLCB2 IPPK NUDT11 INPP5D NUDT10 IP6K2 INPPL1 PPIP5K1 PPIP5K2 IP6K1 NUDT3 IP6K3 NUDT4 PLCG1 MIOX ISYNA1 INPP1 OCRL MTMR9 MTMR7 INPP5B PLCG2 INPP5A IMPA1 SYNJ1 IMPA2 CALM1 INPP5J MINPP1 IPMK PLCZ1 PLCE1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PTEN INPP4A INPP4B ITPK1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.1 PRC2 methylates histones and DNA DNMT3A H2AX H3-3B H2AB1 H2AC19 PHF19 H2AC14 PHF1 H2BC12L DNMT3B JARID2 H2BC21 EZH2 H2BU1 MTF2 H2AC8 H3C15 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 DNMT1 H2BC14 H2AJ SUZ12 H2BC15 H2BC11 RBBP4 RBBP7 H2AZ1 H2BC9 H2AZ2 AEBP2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 EED H3C8 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 80%69895 Transcriptional activation of cell cycle inhibitor p21 ZNF385A PCBP4 CDKN1A TP53 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 80%416482 G alpha (12 13) signalling events TIAM2 BTK FGD1 FGD2 FGD3 ARHGEF10L FGD4 KALRN MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 NET1 ARHGEF17 ARHGEF16 ARHGEF19 VAV3 ARHGEF18 AKAP13 TBXA2R GNG10 RHOC GNA13 GNG12 RHOB GNG11 ARHGEF9 GNG13 ARHGEF3 GNB2 ARHGEF4 GNB1 OBSCN ARHGEF1 GNB4 ARHGEF2 GNB3 TRIO ARHGEF7 ROCK1 GNB5 ARHGEF5 ARHGEF6 GNGT1 GNGT2 PLEKHG5 PREX1 ITSN1 VAV1 PLXNB1 RASGRF2 SOS1 GNG3 VAV2 GNG2 GNG5 TIAM1 GNG4 GNG7 PLEKHG2 GNG8 NGEF ARHGEF40 RHOA SOS2 ROCK2 ARHGEF26 ABR ADRA1D ARHGEF33 GNA12 ARHGEF35 ARHGEF37 ADRA1B ARHGEF38 ADRA1A ECT2 ARHGEF39 MCF2 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.3 Respiratory electron transport COX6C LRPPRC NDUFAB1 TACO1 COX6A1 COX6B1 COX19 COX16 COX18 NDUFC2 COX11 COX14 NDUFS3 CYCS COX20 COX4I1 NDUFA4 TMEM126B UQCRH CYC1 UQCRQ NDUFA5 MT-CYB ETFA NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 NDUFB10 NDUFB11 COQ10B COQ10A COA1 NDUFB8 NDUFA13 NDUFA11 NDUFA12 NDUFA10 ETFDH MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 UQCRC1 UQCRC2 NDUFC1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 ACAD9 MT-CO1 NUBPL NDUFV3 NDUFV2 NDUFV1 UQCRFS1 COX7A2L NDUFS8 SCO1 NDUFS7 SCO2 NDUFS6 NDUFS5 MT-CO2 NDUFS4 MT-CO3 NDUFS2 NDUFS1 SDHC SDHD TMEM186 SDHA ETFB SDHB TIMMDC1 SURF1 ECSIT TRAP1 COX7B UQCR11 UQCR10 COX7C COX8A COX5B COX5A PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9702605 pexidartinib-resistant FLT3 mutants FLT3 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 80%4341670 Defective NEU1 causes sialidosis CTSA NEU1 GLB1 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME%R-HSA-4720454.3 Defective ALG9 causes CDG-1l ALG9 DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 80%192456 Digestion of dietary lipid CLPS PNLIP PNLIPRP1 PNLIPRP2 CEL LIPF PNLIPRP3 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.2 Signaling by NOTCH4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HEY1 PSMD5 PSMD2 HEY2 PSMD3 HES5 PSMD1 CREBBP NOTCH1 TACC3 MAML2 PSMA5 MAML1 PSMA6 PSMA3 PSMA4 RBPJ PSMA1 KAT2B PSMA2 KAT2A PSME3 SNW1 EP300 PSME1 AKT1 PSME2 HES1 MAML3 PSMD10 MAMLD1 PSMD12 PSMD11 PSMD14 YWHAZ PSMD13 PSMA7 ACTA2 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 DLL4 PSMB9 SEM1 PSMC5 SMAD3 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 NOTCH2 UBA52 NOTCH4 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 FLT4 PSEN1 RBX1 JAG1 NCSTN RSK ACTIVATION%REACTOME DATABASE ID RELEASE 80%444257 RSK activation RPS6KA2 RPS6KA1 MAPK1 RPS6KA6 PDPK1 MAPK3 RPS6KA3 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 80%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.1 Acyl chain remodelling of PG LPCAT1 LPGAT1 PLA2G3 PLA2G4F PLA2G2F PLA2G12A PLA2G5 PLA2G2D PLA2G4D PLA2G2E PLA2G4B PLA2G4A PLA2G2A LPCAT4 CRLS1 PLA2G10 PLA2G1B PLA2R1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 80%392451 G beta:gamma signalling through PI3Kgamma GNGT2 PDPK1 PIK3CG AKT3 PIK3R5 PIK3R6 AKT2 GNG3 AKT1 GNG2 GNG5 GNG4 GNG7 GNG8 RHOA GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.6 Interleukin-20 family signaling IFNL2 IFNL1 IFNL3 STAT1 IFNLR1 IL20RA IL10RB IL20RB STAT4 IL22RA2 JAK3 JAK1 STAT3 IL22 TYK2 IL22RA1 IL20 IL26 IL24 STAT5A STAT5B PTPN11 IL19 STAT2 JAK2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 80%171319 Telomere Extension By Telomerase PPP6C RUVBL2 PPP6R3 ANKRD28 TINF2 ACD TERF1 TERF2 CCNA2 CCNA1 SHQ1 DKC1 NOP10 NHP2 RUVBL1 POT1 TERF2IP PIF1 RTEL1 TERT CDK2 GAR1 WRAP53 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.1 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 80%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant JAG2 JAG1 ADAM10 NOTCH1 DLL1 ADAM17 DLL4 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 80%1614603 Cysteine formation from homocysteine CBS CTH HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 80%5358346 Hedgehog ligand biogenesis PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 P4HB SHH PSMA5 PSMA6 IHH PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 DISP2 SCUBE2 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HHAT DHH UBA52 VCP SEL1L DERL2 ERLEC1 OS9 SYVN1 UBB UBC GPC5 RPS27A ADAM17 NOTUM RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 80%8941284 RUNX2 regulates chondrocyte maturation IHH HDAC4 CBFB GLI2 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 80%9614399 Regulation of localization of FOXO transcription factors YWHAQ YWHAG AKT2 FOXO6 FOXO4 FOXO3 FOXO1 AKT1 AKT3 SFN YWHAB YWHAZ ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 80%139915 Activation of PUMA and translocation to mitochondria TP63 TP73 TFDP1 BBC3 TFDP2 TP53BP2 PPP1R13B E2F1 TP53 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 80%3560782 Diseases associated with glycosaminoglycan metabolism CHST3 PAPSS2 SDC4 NCAN B4GALT7 SDC2 SDC3 ST3GAL3 B3GAT3 BGN B3GALT6 VCAN GPC1 GPC3 CSPG5 SDC1 GPC2 GPC5 EXT1 EXT2 CSPG4 GPC4 DCN CHST6 AGRN GPC6 LUM OGN OMD KERA PRELP FMOD B4GALT1 HSPG2 SLC26A2 BCAN HEXB HEXA ACAN CHST14 CHSY1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-HSA-177504.1 Retrograde neurotrophin signalling CLTC NGF SH3GL2 CLTA AP2S1 AP2A1 AP2B1 AP2A2 NTRK1 DNM1 AP2M1 DNM2 DNM3 DNAL4 KINESINS%REACTOME%R-HSA-983189.3 Kinesins KIF6 KIF16B KIF20A KIF27 KIF20B KIF9 KIFC2 KIF2A KIFC1 KLC1 KIF2C KIF2B KLC4 KLC3 KLC2 KIF3B KIF3C CENPE KIF26A KIF18A KIF26B KIF18B KIF4B KIF4A KIF3A RACGAP1 KIF12 KIF11 KIF15 KIF28P KIF19 KIF13B KIF1C KIF5C KIF5B KIF1B KIF5A KIF1A KIF21A KIF21B KIF25 KIFAP3 KIF23 KIF22 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.2 Pre-NOTCH Processing in the Endoplasmic Reticulum POGLUT1 NOTCH2 POFUT1 NOTCH3 NOTCH1 NOTCH4 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 80%1442490 Collagen degradation ELANE COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 MMP20 CTSL CTSK COL16A1 COL12A1 CTSD CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 MMP10 PRSS2 MMP12 MMP11 PHYKPL MMP14 MMP13 COL23A1 MMP15 ADAM10 MMP19 ADAM17 COL15A1 TMPRSS6 ADAM9 COL17A1 FURIN COL13A1 COL19A1 COL26A1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 80%68616 Assembly of the ORC complex at the origin of replication H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 H2AC8 H3C15 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 ORC5 H2BC14 ORC4 H2AJ ORC6 H2BC15 ORC1 H2BC11 ORC3 ORC2 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 KPNB1 H2BC3 H2BC1 KPNA6 KPNA1 H2AC20 H3C8 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.2 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR3GL TBP POLR1C POLR1D GTF3C1 GTF3C2 POLR2E POLR3A GTF3C3 POLR2F POLR3B GTF3C4 POLR3C GTF3C5 POLR2H POLR3D GTF3C6 POLR3E POLR2K POLR3F POLR2L POLR3G POLR3H POLR3K BRF1 GTF3A BDP1 CRCP DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 80%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 80%9020958 Interleukin-21 signaling IL2RG JAK1 STAT5A STAT3 STAT5B IL21 IL21R STAT1 STAT4 JAK3 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.1 Negative regulation of NOTCH4 signaling PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 TACC3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 AKT1 PSME2 PSMD10 PSMD12 PSMD11 PSMD14 YWHAZ PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 UBA52 NOTCH4 CUL1 UBB UBC RPS27A RBX1 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 80%201556 Signaling by ALK HDAC1 IRS1 SIN3A CD274 PIK3CB HIF1A PIK3R1 HDAC2 PRDM1 PIK3CA PLCG1 EP300 FRS2 MDK JAK3 MYC PTPN6 PTPRZ1 STAT3 PIK3R2 IL2RG PTN ALK MYCN HDAC3 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.4 Synthesis of PC ABHD3 CHAT CEPT1 BCHE CHKB CHKA STARD10 PEMT SLC44A5 CHPT1 ACHE SLC44A3 LPIN1 SLC44A4 LPIN2 SLC44A1 LPIN3 SLC44A2 LPCAT1 PCTP PCYT1B PCYT1A MFSD2A CSNK2A1 STARD7 CSNK2A2 PHOSPHO1 CSNK2B FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 80%5654712 FRS-mediated FGFR4 signaling FGF19 FGFR4 FGF16 FGF18 KLB NRAS SOS1 HRAS FRS2 FRS3 PTPN11 FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNG10 KCNJ4 GABBR2 KCNJ5 GABBR1 KCNJ10 KCNJ12 GNG12 KCNJ9 GNG11 GNG13 KCNJ15 GNB2 KCNJ16 GNB1 GNB4 GNB3 GNB5 GNGT1 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 80%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME%R-HSA-9627069.1 Regulation of the apoptosome activity APIP CYCS MAPK1 XIAP DIABLO MAPK3 CARD8 CASP9 APAF1 UACA AVEN TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.2 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.3 NOTCH1 Intracellular Domain Regulates Transcription NCOR1 TBL1XR1 HDAC1 HEY1 TBL1X HEY2 HES5 HIF1A CREBBP HEYL NOTCH1 UBA52 MAML2 HDAC10 HDAC2 MAML1 HDAC11 TLE4 RBPJ HDAC8 TLE2 TLE1 KAT2B KAT2A SNW1 CUL1 HDAC9 EP300 HES1 MAML3 MAMLD1 UBB HDAC6 UBC HDAC7 HDAC4 MYC RPS27A NBEA CDK8 SKP1 HDAC5 CCNC RBX1 NCOR2 HDAC3 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 80%5578749 Transcriptional regulation by small RNAs NUP62 NUP214 NDC1 SEC13 NUP210 NUP133 H3C15 NUP93 NUP50 NUP54 NUP205 POM121 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP88 NUP43 AGO1 RAN RAE1 AGO2 RANBP2 NUP155 NUP153 NUP35 NUP37 TNRC6A H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L H2BC21 H2BU1 IPO8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 POLR2A H2BC14 POLR2B H2AJ POLR2C H2BC15 POLR2D H2BC11 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J H2AZ1 POLR2K H2BC9 POLR2L H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NUP107 NUP188 H3C8 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 80%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATG14 HSPA5 SEC13 PIK3R4 SEC31A SAR1B TAP2 TAP1 CANX SEC23A PIK3C3 CALR BECN1 TAPBP SEC24B SEC24A ERAP2 ERAP1 HLA-H HLA-B SEC24D PDIA3 HLA-C HLA-A SEC24C HLA-F HLA-G HLA-E B2M IGF1R SIGNALING CASCADE%REACTOME%R-HSA-2428924.1 IGF1R signaling cascade IRS1 TRIB3 FLT3 PIK3CB PDPK1 PIK3R4 FLT3LG GAB1 GAB2 PIK3R1 TLR9 KLB NRAS PIK3CA SOS1 AKT2 HRAS FRS2 FGF1 IGF1 FGF2 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 FGF10 IRS2 FGF19 PIK3C3 PIK3R2 FGFR4 THEM4 FGF16 FGF7 FGF18 PDE3B IRS4 IGF1R IGF2 PTPN11 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.7 Assembly of the pre-replicative complex ANAPC11 PSMD8 FZR1 PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 PSMD3 PSMD1 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 PSMA4 H3C15 PSMA1 PSMA2 PSME3 UBE2S PSME1 PSME2 CDC16 PSMD10 ANAPC4 ANAPC5 PSMD12 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 KPNA1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H3-3B GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNB1 H2AX H2AB1 H2AC19 H2AC14 H2BC12L UBA52 H2BC21 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 UBB UBC H2AZ1 H2BC9 RPS27A H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 KPNA6 H2AC20 MCM7 MCM8 H3C8 MCM3 UBE2D1 ANAPC15 MCM4 MCM5 ANAPC16 MCM6 ANAPC10 MCM2 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 80%5218900 CASP8 activity is inhibited TNFSF10 TNFRSF10B FAS TNFRSF10A TRADD FASLG TRAF2 CASP8 RIPK1 FADD MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 80%9022699 MECP2 regulates neuronal receptors and channels HDAC1 SIN3A OPRK1 PTPN4 GRIA2 MET PTPN1 HDAC2 GPRIN1 SLC2A3 GRIN2B FKBP5 GRIN2A OPRM1 CREB1 TRPC3 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.3 RHO GTPases Activate ROCKs PAK1 RHOA PPP1CB PPP1R12B ROCK2 CFL1 RHOC RHOB MYL12B MYH9 LIMK2 MYH14 LIMK1 MYH11 PPP1R12A ROCK1 MYH10 MYL6 MYL9 SIGNALING BY NTRKS%REACTOME%R-HSA-166520.4 Signaling by NTRKs RPS6KA2 RPS6KA1 TPH1 ATF1 MAP2K5 SH3GL2 YWHAB SRC MAPKAPK3 MAPKAPK2 GRIN2B KIDINS220 BRAF BAX PPP2CA PPP2CB MAPK1 MAPK3 MAPK11 CDK5R1 CLTC CLTA SHC1 RAC1 GAB1 PIK3R1 MAPK12 MAPK13 NRAS PIK3CA PLCG1 CRK SOS1 HRAS TIAM1 RAPGEF1 MAP2K1 NGF RHOA PIK3R2 NELFB SRF DNM1 DNM2 DNM3 PTPRO PCSK6 PCSK5 ATF2 MEF2D NAB1 NAB2 IRS1 CRKL PIK3CB ID1 TCF12 EGR1 SH3GL3 ARC TRIB1 SHC2 SHC3 RRAD RALGDS EGR3 EGR4 FOSL1 ID2 ADCYAP1 ID4 EP300 ID3 DNAL4 ADCYAP1R1 LYL1 MAPK14 RALB ASCL1 RIT1 RIT2 CDK5R2 FOS IRS2 PPP2R1A DUSP4 DUSP3 PPP2R5D VRK3 CHD4 DUSP6 NTRK1 DUSP7 NTRK2 MAPK7 PPP2R1B FURIN JUND REST PTPRS ADORA2A FOSB F3 NTRK3 NTF3 JUNB FRS2 ELK1 FRS3 RALA CREB1 EGR2 CDK5 VGF STAT3 DOCK3 AP2S1 AP2A1 AP2B1 AP2A2 NTF4 AP2M1 BDNF RAP1A PTPN11 MAP2K2 MEF2A SGK1 MEF2C RPS6KA3 RPS6KA5 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 80%168142 Toll Like Receptor 10 (TLR10) Cascade IKBKB RPS6KA2 RPS6KA1 ATF1 IKBKG MAP3K7 MAP2K6 CHUK MAPKAPK3 MAPKAPK2 RIPK2 UBE2V1 MAP2K4 MAPK14 MAP2K7 NOD1 JUN NOD2 FOS PPP2CA MAPK9 RELA PPP2CB MAPK8 MAPK10 MAPK1 IRAK1 PELI3 MAPK3 PELI2 PELI1 PPP2R1A DUSP4 MYD88 BTRC DUSP3 NFKB1 PPP2R5D VRK3 TLR10 DUSP6 NFKBIA MAP2K3 DUSP7 TLR5 UBE2N MAPK7 TAB3 PPP2R1B IRAK4 TAB2 SKP1 TAB1 FBXW11 NFKBIB MAPK11 APP HMGB1 TRAF6 UBA52 NKIRAS1 NKIRAS2 CUL1 ELK1 CREB1 UBB MAP2K1 UBC TNIP2 MAP3K8 IRAK2 RPS27A AGER S100A12 ECSIT MAP3K1 S100B NFKB2 SAA1 ATF2 MEF2A MEF2C RPS6KA3 RPS6KA5 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 80%189200 Cellular hexose transport SLC2A6 FGF21 SLC2A7 SLC2A2 SLC5A10 SLC2A4 SLC50A1 SLC5A2 SLC2A10 SLC2A3 SLC5A9 SLC45A3 SLC5A1 SLC2A8 SLC5A4 SLC2A14 SLC2A11 SLC2A9 SLC2A12 SLC2A1 MFSD4B SIGNALING BY FGFR1%REACTOME%R-HSA-5654736.4 Signaling by FGFR1 GAB1 PIK3R1 UBA52 CBL NRAS FGFRL1 PIK3CA PLCG1 SOS1 HRAS FRS2 FRS3 FGF1 FGF2 FGF3 FGF4 UBB FGF6 ANOS1 FGF9 FLRT2 FLRT3 FGF20 SPRED2 UBC FLRT1 FGF23 BRAF PPP2CA SPRED1 FGF22 PPP2CB FGF10 MKNK1 RPS27A MAPK1 SPRY2 MAPK3 PPP2R1A FGF18 PTPN11 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 80%9674401 Sunitinib-resistant PDGFR mutants PDGFRA N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 80%975576 N-glycan antennae elongation in the medial trans-Golgi ST8SIA6 ST8SIA3 FUT8 MAN2A1 MGAT5 ST3GAL4 FUCA1 MGAT2 CHST10 CHST8 FUT3 MGAT3 ST6GAL1 B4GALT2 LHB B4GALT3 MGAT4C ST8SIA2 MAN2A2 MGAT4A MGAT4B CGA B4GALT6 B4GALT4 B4GALT1 B4GALT5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.3 Platelet Adhesion to exposed collagen VWF LYN GP1BB FYN GP1BA GP5 GP9 ITGA2 ITGA10 ITGA1 ITGB1 GP6 FCER1G CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 80%5690714 CD22 mediated BCR regulation IGKV1-17 CD79B IGKV1-12 CD79A IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PTPN6 IGKV3-15 IGKV3-11 LYN IGHM IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGHD IGKV3D-20 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 CD22 IGLC6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 80%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 RELA PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 BTRC PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SKP1 PSMC3 PSMC4 PSMC1 PSMC2 FBXW11 RELB MAP3K14 UBA52 CUL1 UBB UBC RPS27A UBA3 UBE2M NFKB2 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 80%5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.2 Miscellaneous substrates CYP4F22 CYP2W1 CYP2D6 CYP2S1 CYP4A22 CYP4F2 CYP4A11 CYP4F3 CYP4B1 CYP3A43 CYP4F11 CYP2U1 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.1 CRMPs in Sema3A signaling PLXNA1 CDK5R1 FES FYN PLXNA2 NRP1 PLXNA4 PLXNA3 SEMA3A GSK3B CRMP1 DPYSL4 DPYSL5 DPYSL2 CDK5 DPYSL3 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 80%9603798 Class I peroxisomal membrane protein import PEX14 PXMP2 PXMP4 ABCD2 ATAD1 PEX16 PEX11B PEX19 ABCD1 GDAP1 PEX2 SLC25A17 PEX3 FIS1 ACBD5 PEX26 PEX12 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 80%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAF9B TAF9 CCNH TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 TBP TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 POLR2A POLR2B GTF2F1 POLR2C GTF2F2 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K CDK7 POLR2L MNAT1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2B GTF2E1 GTF2E2 ERCC3 ERCC2 TAF4B TAF7L GTF2A1 GTF2A2 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717319.1 brigatinib-resistant ALK mutants ALK PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 80%165160 PDE3B signalling PDE3B AKT2 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 80%9703009 tamatinib-resistant FLT3 mutants FLT3 PARASITE INFECTION%REACTOME%R-HSA-9664407.1 Parasite infection IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DOCK1 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 FCGR3A IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MAPK1 IGKV3-15 IGKV3-11 MAPK3 LYN V2-8 IGHG3 V1-20 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGHG2 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 NCKAP1 IGHV4-34 CYFIP1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 BRK1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 ARPC4 ARPC5 V1-3 IGKV3D-20 V5-6 FYN RAC1 ARPC2 ARPC3 IGLV3-19 VAV1 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 CRK IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 V4-6 NCK1 IGHV3-53 ACTR3 VAV2 V4-2 IGLC7 ACTR2 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD3G YES1 MYH9 NCKAP1L WASF3 WASF1 WASF2 MYO1C ELMO1 FGR BAIAP2 BTK ABI2 ABI1 HCK ACTB PTK2 VAV3 WASL SYK MYO5A MYH2 MYO10 WAS CYFIP2 WIPF1 WIPF2 WIPF3 MYO9B ABL1 ACTG1 ELMO2 NCKIPSD ARPC1B ARPC1A IGHV3-23 IGLV IGLV2-8 IGKV1-16 MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 80%112411 MAPK1 (ERK2) activation JAK1 MAPK1 PTPN11 TYK2 MAP2K2 IL6 IL6R JAK2 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.3 ATF4 activates genes in response to endoplasmic reticulum stress ASNS EXOSC2 IGFBP1 EXOSC1 CEBPG CXCL8 HERPUD1 KHSRP CCL2 DIS3 CEBPB DCP2 PARN EXOSC7 NFYA EXOSC6 NFYB ATF3 EXOSC5 DDIT3 EXOSC4 NFYC EXOSC9 ATF6 EXOSC8 ATF4 EXOSC3 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.3 GAB1 signalosome AREG EGF GAB1 PIK3R1 PAG1 SRC TGFA EGFR PIK3CA CSK EPGN PXN BTC PTPN11 HBEGF EREG ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME%R-HSA-162791.2 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT PIGK PLAUR GPAA1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 80%2243919 Crosslinking of collagen fibrils BMP1 TLL2 TLL1 LOX PXDN PCOLCE LOXL3 LOXL4 LOXL1 LOXL2 NICOTINAMIDE SALVAGING%REACTOME DATABASE ID RELEASE 80%197264 Nicotinamide salvaging PARP14 RNLS PARP8 NAMPT NUDT12 NAXD SLC5A8 NNMT PTGIS CYP8B1 SLC22A13 PTGS2 NAPRT PARP10 PARP6 PARP4 NAXE PARP16 PARP9 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.2 Nucleotide Excision Repair SUMO3 SUMO2 GPS1 TCEA1 PARP1 PIAS1 ZNF830 ISY1 HMGN1 XPC UVSSA UBE2N RPA1 UBE2V2 COPS4 COPS2 RAD23A RAD23B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F ERCC8 POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L YY1 ACTB PCNA POLD3 POLD4 POLD1 POLD2 EP300 POLK POLE RFC5 RFC3 USP7 RFC4 LIG1 RFC1 RFC2 RPA2 XRCC1 LIG3 POLE4 CETN2 RPA3 POLE2 POLE3 PIAS3 UBE2I SUMO1 NFRKB ACTR5 ACTL6A CCNH USP45 ACTR8 INO80C INO80B INO80E INO80D COPS7B COPS7A TFPT MCRS1 UBA52 INO80 RUVBL1 COPS3 AQR COPS6 COPS5 COPS8 PPIE UBB UBC CDK7 PRPF19 MNAT1 RPS27A XPA PARP2 GTF2H1 CHD1L GTF2H2 GTF2H3 GTF2H4 GTF2H5 DDB2 CUL4A DDB1 ERCC3 ELL ERCC4 ERCC1 ERCC2 ERCC5 CUL4B XAB2 RBX1 ERCC6 RNF111 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.1 Signaling by MAP2K mutants MAPK1 MAPK3 MAP2K2 MAP2K1 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 80%2467813 Separation of Sister Chromatids ANAPC11 PSMD8 INCENP PSMD9 PSMD6 CDC23 PSMD7 PSMD4 PSMD5 CDC26 PSMD2 CDC27 KIF2A PSMD3 SEC13 PSMD1 NUP133 KIF2C KIF2B ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 SMC1A PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 UBE2S PSME1 PSME2 CDC16 PSMD10 CENPE ANAPC4 PSMB11 CENPF ANAPC5 PSMD12 TAOK1 ANAPC1 PSMD11 ANAPC2 PSMD14 PSMD13 NUP160 PSMA7 PPP2CA PPP2CB PSMB10 NUP85 PSMA8 RAD21 PSMB6 PPP1CC PSMB7 PSMB4 PSMB5 PSMB2 NUP43 PSMB3 PSMB1 RANBP2 PSMF1 AURKB PSMB8 PSMB9 SEM1 BUB1 PSMC5 CLASP2 PSMC6 CLIP1 RPS27 PSMC3 PSMC4 PSMC1 MAD1L1 PSMC2 STAG1 STAG2 NUP37 PTTG1 NDC80 CDCA5 PDS5B SPDL1 PDS5A WAPL RANGAP1 BIRC5 BUB1B CDC20 BUB3 MAD2L1 NSL1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C ZW10 DSN1 RCC2 ZWINT AHCTF1 XPO1 NDEL1 PPP2R1A PPP2R5D PPP2R1B MIS12 DYNLL1 CKAP5 DYNC1I1 MAPRE1 UBA52 PAFAH1B1 B9D2 DYNC1I2 KNL1 SPC24 SPC25 ERCC6L ZWILCH DYNC1LI1 DYNC1LI2 ESPL1 UBB ITGB3BP KIF18A CENPA CENPC UBC KNTC1 CDCA8 RPS27A CENPT CENPU SGO1 CLASP1 SGO2 SKA1 SKA2 DYNC1H1 NDE1 PLK1 PMF1 CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS NUP107 NUF2 NUDC UBE2D1 ANAPC15 ANAPC16 DYNLL2 SMC3 ANAPC10 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 80%190704 Oligomerization of connexins into connexons GJB2 GJB1 GJA1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2894858.1 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HEY1 HEY2 HES5 CREBBP HEYL NOTCH1 MAML2 HDAC10 MAML1 HDAC11 HDAC2 RBPJ HDAC8 KAT2B KAT2A SNW1 EP300 HDAC9 HES1 MAML3 MAMLD1 HDAC6 HDAC7 MYC HDAC4 JAG2 MIB2 DLL1 MIB1 DLL4 NEURL1B NEURL1 CDK8 SKP1 HDAC5 CCNC NCOR2 HDAC3 NCOR1 TBL1XR1 HDAC1 TBL1X UBA52 CUL1 UBB UBC RPS27A APH1A PSENEN APH1B ADAM10 PSEN2 ADAM17 PSEN1 RBX1 JAG1 NCSTN ASPIRIN ADME%REACTOME DATABASE ID RELEASE 80%9749641 Aspirin ADME UGT3A2 UGT3A1 GLYATL3 GLYATL2 BCHE GLYATL1 ALB CYP2C9 CYP2C8 SLC22A7 ACSM2A ACSM2B UGT1A3 UGT2A3 UGT2A2 UGT2A1 ABCC3 UGT1A1 UGT2B4 UGT2B7 UGT2B28 CYP3A4 UGT1A5 UGT1A9 UGT1A8 BSG UGT1A7 UGT1A6 SLC16A1 UGT1A4 ACSM5 ACSM4 CYP2D6 UGT2B10 UGT2B11 ABCC2 UGT2B15 UGT2B17 CYP2E1 CES2 CES1 GLYAT CYP2C19 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.1 IRAK4 deficiency (TLR2 4) FGB FGA BTK HMGB1 FGG LY96 CD36 CD14 S100A1 MYD88 TIRAP TLR1 S100A9 TLR6 S100A8 TLR4 IRAK4 TLR2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.3 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 GGCX FURIN PROC F10 F9 PROS1 GAS6 PROZ BGLAP F2 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.2 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 PRKCZ NRAS EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 80%212165 Epigenetic regulation of gene expression HDAC2 H3C15 TDG DEK BAZ1B HDAC1 SIN3A H3-3B UHRF1 PHF19 PHF1 JARID2 TET2 TET1 TET3 MTF2 DNMT3L POLR2E POLR2F POLR2H POLR2K POLR2L AEBP2 GSK3B EZH2 ACTB DDX21 KAT2B KAT2A EP300 MBD3 SUZ12 GATAD2B GATAD2A CHD4 CHD3 EED MTA1 MTA2 MTA3 MYBBP1A CCNH SUV39H1 DNMT3A ARID4B H2AX H2AB1 TTF1 H2AC19 RRP8 SIN3B SAP130 H2AC14 UBTF H2BC12L DNMT3B SAP30BP H2BC21 TBP SIRT1 SAP30 H2BU1 POLR1A H2AC8 POLR1B H2AC6 POLR1C H2AC7 POLR1D POLR1E H2BC17 POLR1F H2BC12 POLR1G H2BC13 POLR1H DNMT1 H2BC14 BAZ2A H2AJ H2BC15 TAF1D H2BC11 TAF1B TAF1C SAP30L TAF1A RBBP4 SAP18 SUDS3 RBBP7 H2AZ1 MBD2 CDK7 H2BC9 MNAT1 H2AZ2 GTF2H1 H4C9 H2BC8 GTF2H2 GTF2H3 GTF2H4 H2BC5 GTF2H5 H2BC3 SMARCA5 H2BC1 ERCC3 SF3B1 H2AC20 ERCC2 EHMT2 CBX3 H3C8 ERCC6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 80%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle RNF103 RNF139 MLEC TRIM13 UGGT2 RNF185 UGGT1 MARCHF6 PRKCSH UBA52 GANAB VCP SEL1L DERL2 RAD23B OS9 SYVN1 ENGASE NGLY1 EDEM2 DERL1 UBB MOGS UBC RPS27A CANX MAN1B1 CALR PDIA3 PSMC1 UBXN1 EDEM3 EDEM1 AMFR RNF5 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 80%5659898 Intestinal saccharidase deficiencies SI LCT DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 80%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.2 Transport of Mature mRNA Derived from an Intronless Transcript NUP62 NUP214 NDC1 NXF1 SEC13 NUP210 NUP133 ALYREF CPSF4 CPSF1 NUP93 CPSF3 CPSF2 NUP50 NUP54 NUP205 EIF4E POM121 SYMPK AAAS FIP1L1 NUP160 POM121C NUP42 NUP85 TPR WDR33 NUP88 NUP43 RAE1 NCBP1 RANBP2 NCBP2 NUP155 NUP153 NUP107 NUP188 NUP35 NUP37 DEFECTIVE MTR CAUSES HMAG%REACTOME%R-HSA-3359469.2 Defective MTR causes HMAG MTRR MTR G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 80%418594 G alpha (i) signalling events CCL19 CCL20 CAMK2B CAMK2D SRC CAMK2A CALM1 CAMK2G PPP1R1B PDE4B GPR31 PLCB3 PLCB4 PLCB1 PLCB2 CCL4L2 RGS5 RGS3 PRKACG RGS1 PRKACB RGS8 PCP2 OPRD1 GPSM1 CHRM2 GPSM2 ADCY9 GPSM3 RGS18 PRKAR1B CHRM4 RGS14 PRKAR1A RGS13 RGS21 RGS22 CXCR1 RGS10 PLA2G4A RGS12 PRKAR2A CXCR2 CXCL6 GNAS CXCL9 CXCL13 CXCL3 CXCL5 CX3CL1 CXCL16 HRH4 CCR9 CCR8 DRD3 CCR7 DRD4 AHCYL1 CCR4 CCR3 ADCY4 HTR1E ADCY3 C5AR1 HTR1F CX3CR1 CCL13 ADCY2 CXCR5 ADCY1 HTR1D CXCR6 ADCY8 PDE1C PDE1B ADCY7 PDE1A ADCY6 CXCR3 HTR1B ADCY5 ITPR1 CCL1 ITPR2 ADRA2C CCL16 ITPR3 HTR5A CCR10 CCL25 ADRA2B ADRA2A CCL21 CXCL11 CXCL8 ACKR3 CCL28 CXCL1 CCL27 PRKX CXCL2 CAMKK1 CAMKK2 OPRM1 KPNA2 GNAL GRK2 PPP2R1A NBEA C3 PRKACA APP RXFP4 RRH PRKCD RXFP3 HEBP1 ANXA1 MT-RNR2 OXER1 FPR1 FPR3 FPR2 PRKAR2B GPR37L1 C5 CDK5 PDYN AGTR2 LPAR1 LPAR2 LPAR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 PPY GNAT2 GNAT1 GPR17 SAA1 LPAR5 NMS GPR183 NMU PNOC GPR18 TAS2R7 TAS2R60 PTGDR2 PRKCG TAS2R40 PRKCA TAS2R9 TAS2R41 TAS2R8 TAS2R20 TAS2R42 OPN1LW TAS2R43 TAS2R45 OXGR1 C3AR1 TAS2R46 GPR37 GRM3 GRM2 GRM4 GRM7 GAL GRM6 OPN1MW GRM8 TAS2R1 RGR RGS17 TAS1R2 NPB RGS19 TAS1R1 RGSL1 TAS2R3 RGS16 TAS1R3 RGS4 TAS2R5 TAS2R4 RGS20 TAS2R50 PTGER3 CASR TAS2R30 TAS2R31 CXCL10 TAS2R10 TAS2R13 NPW TAS2R14 TAS2R38 PPP2CA TAS2R16 PPP2CB P2RY12 TAS2R39 P2RY13 TAS2R19 MAPK1 P2RY14 GPR55 AGT CCL5 CCL4 PMCH NPY2R ADORA3 ADORA1 CXCR4 NPY1R MTNR1A MTNR1B APLNR SUCNR1 MCHR2 HCAR2 HCAR3 HCAR1 OPN3 OPN5 CAMK4 PYY NMUR2 NMUR1 BDKRB2 BDKRB1 CCR1 INSL5 NPY5R SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R OPRL1 CNR2 P2RY4 CNR1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 APLN GABBR2 OPN1SW CCR6 GABBR1 CCR5 CCR2 SST GNAT3 PPP3CC GNAZ RGS9 RGS6 RGS7 PPP1CA CXCL12 PPBP PSAP GNG10 RLN3 GNG12 GNG11 PPP2R5D GNG13 PPP3CA GNAQ GNB2 PPP2R1B GNB1 GNB4 GPER1 PDE4A GNB3 GNB5 KNG1 PDE4D GNGT1 PDE4C GNGT2 PENK GNAI3 GNAI1 GNAI2 SSTR3 GNA14 GNA15 GNG3 PF4 CREB1 GNG2 GNG5 GNG4 POMC PPP3R1 GNA11 GNG7 GNG8 MCHR1 RHO RGS11 PPP3CB NPY ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.2 Activation of anterior HOX genes in hindbrain development during early embryogenesis YY1 PIAS2 MEIS1 PAX6 CREBBP RARB KMT2D EZH2 KMT2C H3C15 EP300 ZNF335 SUZ12 JUN RARA EED MAFB PCGF2 RXRA PAGR1 WDR5 HDAC3 NCOR1 H2AX H3-3B H2AB1 H2AC19 H2AC14 H2BC12L CNOT6 H2BC21 AJUBA H2BU1 H2AC8 H2AC6 H2AC7 PAXIP1 HOXA3 HOXA2 H2BC17 PBX1 CNOT9 HOXA1 H2BC12 H2BC13 POLR2A CTCF HOXA4 H2BC14 POLR2B RBBP5 H2AJ POLR2C H2BC15 POLR2D H2BC11 POLR2E POLR2F POLR2G RBBP4 POLR2H EGR2 RBBP7 POLR2I POLR2J H2AZ1 POLR2K H2BC9 POLR2L H2AZ2 H4C9 H2BC8 HOXB4 HOXB3 H2BC5 HOXB2 H2BC3 HOXB1 KDM6A HOXD1 H2BC1 NCOA6 NCOA3 HOXC4 H2AC20 HOXD4 HOXD3 RARG H3C8 ASH2L RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME%R-HSA-8935964.1 RUNX1 regulates expression of components of tight junctions CLDN5 CBFB TJP1 OCLN RUNX1 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20220510%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNA4 IFNA1 IFIH1 TBK1 IF1AA3 IKBKE IF1AA1 JAK1 IFNAR2 IF1AA6 IFNA13 IF1AA5 IF1DA1 IF1AA4 IFNA14 STAT1 DDX58 IF1AA9 STAT2 IF1AA8 TYK2 TICAM1 ACE2 MAVS IRF3 TRAF3 IF1AB4 IRF9 TLR3 IFNAR1 IF1AB1 VASOPRESSIN-REGULATED WATER REABSORPTION%WIKIPATHWAYS_20220510%WP5085%HOMO SAPIENS Vasopressin-regulated water reabsorption AQP2 AQP3 ADCY6 DYNC2LI1 HEL-S-47e DKFZp686I0746 CREB3L3 CREB3L4 PRKACG ARHGDIB DKFZp686N2325 STX4A DYNC1I1 DYNC2H1 DYNC1H1 AVPR2 DKFZp761J032 DYNLL2 RAB11A RAB11B DYNC1LI1 CREB3 DKFZp686J08252 ADCY9 CREB1 GNAS AVP DNCL1 RAB5A VAMP2 CREB5 DCTN6 DCTN5 RAB5B RAB5C ARHGDIG ADCY3 AQP4 HEL-S-77 GPCRS, CLASS A RHODOPSIN-LIKE%WIKIPATHWAYS_20220510%WP455%HOMO SAPIENS GPCRs, class A rhodopsin-like OR2B6 DRD3 DRD4 DRD5 OR2B3 OR2B2 OPN4 OPN3 HTR1E HTR1F HTR1D HTR1B MGRA MGRH GPER NMUR2 NMUR1 OR2A4 OR7A10 OR14J1 OR1G1 MLNR HTR2B ADRA1D HTR2A ADRA1B ADRA1A LTB4R BDKRB2 BDKRB1 PRLHR OR8D2 OR7A17 PTGIR NPY5R OR1F1 OR2H1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 ADRA2A SSTR4 SSTR5 ADORA2A ADORA2B OR7A5 OR10A4 OR10A5 CX3CR1 OR1E2 NPY4R OR1E1 P2RY6 CNR2 OR8B8 P2RY4 CNR1 OR2W1 P2RY2 P2RY1 OR12D3 OR1D5 OR1D2 OR2F2 OR2F1 OPRK1 HCRTR2 HCRTR1 OPN1SW OPN1MW3 ACKR4 ACKR3 OR11A1 AVPR2 NPFFR2 OXTR NPFFR1 RRH GRPR HTR4 GPR174 GPR173 EDNRA HTR6 EDNRB HTR7 GPR171 KPG_011 C3AR1 KPG_010 CMKLR2 PTGDR CMKLR1 GPR37L1 FPRL1 FPRL2 TRHR GPR161 AGTR1 AGTR2 PTGFR FPR1 OR1I1 LPAR4 IL8RB MC2R GALR3 GALR2 GALR1 NPBWR2 OR6B1 CCR10 NTSR1 NTSR2 CCR1 GPR17 XCR1 GPR15 OR2J3 OR2J2 NMBR MC1R OR6A2 RGL4 OR7C2 OR7C1 GPR19 GPR27 OR10J1 GPR25 PTGDR2 GPR22 CCBP2 BRS3 MC4R CCKAR CCR8 FFAR3 CCR7 FFAR2 CCR6 FFAR1 CCR5 CCR4 CCR3 CCR2 GPR39 OR5F1 GPR37 GPR34 AVPR1B GPR32 GPR31 AVPR1A MC3R OR5V1 ADRB3 CCKBR FSHR OR3A3 OR3A2 OR3A1 OPRD1 PTGER4 OR10H1 RABGAP1 GPR45 OR10H3 PTGER1 OR10H2 PTGER2 PTGER3 CXCR5 CXCR4 hCG_1644110 CXCR1 OR2AG1 CXCR3 RHO P2RY13 P2RY10 P2RY11 P2RY14 GPR52 GPR4 GPR50 GPR3 GPR6 MC5R F2RL1 5HT1A F2RL2 F2RL3 CHRM2 CHRM3 CHRM1 OR1C1 GPR68 CHRM4 GPR65 CHRM5 NPY2R GPR63 CCRL2 GHSR OR2D2 LHCGR F2R NPY1R GPR75 MTNR1A OR2T1 MTNR1B OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 C5AR2 GPR87 GPR85 GPR83 ADRB1 ADRB2 MCHR1 HCAR3 OR1Q1 OR2S2 HRH1 HCAR1 HRH3 HRH2 TBXA2R DRD1 DRD2 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20220510%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMS TYMP TDG FPGS UPP2 TK1 ABCC3 RRM1 RRM2 ABCC5 XRCC3 GGH SMUG1 DHFR CYP2A6 UCK2 UCK1 DPYD ERCC2 UMPS SLC29A1 SLC22A7 CES2 ABCG2 CES1 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20220510%WP5193%HOMO SAPIENS Cholesterol synthesis disorders FDPS IDI1 MVK HMGCS1 HSD3B2 CYP51A1 DHCR24 MSMO1 HMGCR EBP DKFZp686B0215 PMVK MVD DHCR7 LBR SC5DL FDFT1 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20220510%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 NUCLEAR RECEPTORS META-PATHWAY%WIKIPATHWAYS_20220510%WP2882%HOMO SAPIENS Nuclear receptors meta-pathway ACKR3 ABCC3 ABCC5 CYP2A6 CES2 CES1 KEAP1 GCC1 IF2F FTH1 MYC PDK4 IL12B CYP1B1 IL12A TNS4 JUNB SULT2A1 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A8 SLC5A9 CDC37 CES8 CES3 EPHA3 EPHA2 ABCB1 HEL-S-10 MGST3 ABCB4 MGST1 MGST2 TGFA TXN SLC5A1 ADH7 SLC6A20 SLC5A2 SLC5A4 SLC5A5 SULT1A1 CYP2B6 HMOX1 PCK1 GGTLA4 PPARGC1A SLC19A2 EGR1 GSTM3 JUN GSTM2 GSTM1 JUND GADD45B PLK2 SMARCA1 NR0B2 CDC2 HEL-S-128m SLC6A5 CYP2C9 SLC6A7 SLC6A8 SLC6A9 FASN CYP1A2 CYP1A1 SNAI2 CPEB4 GSTM5 CDKN1C SERPINA1 CDKN1B SLC7A11 SLC6A1 SLC6A2 SLC6A3 GGTLC2 EPB41L4B FGF8A DNER ENC1 ANKRD1 ACADM NCOA1 IL11 SLC2A14 FGFBP1 EDN2 SERPINB2 SLC2A11 NCOA6 SLC2A10 TSC22D3 SLC2A13 SLC2A12 MYOF SLC39A11 SLC39A10 SERPINB9 SLC39A13 SLC39A12 PTGR1 BAAT SLC39A14 POU5F1 HEL-75 KAT2B SLC7A5 B3GNT5 IL1B CDC42EP3 AHRR PMP2 ANGPTL4 HBEGF NR1I3 AMIGO2 PTGS2 ABCB11 CYP7A1 EGFR PTPA FGD4 SRPX2 GPR153 RXRA SERTAD2 NQO1 NR1i1 CAVIN2 CCL20 PTGES3 STAT3 NR1i2 NR1H4 NR1H3 KLK15 KTN1 FABP1 GSTA5 GPAM GSTA4 GSTA3 IL17B SLC27A1 TNF-alpha AHR NR3C1 RGS2 CCND1 SLC39A9 SLCO2B1 SLC39A6 SLC39A5 EP300 SLC39A8 SLC39A2 SLC39A1 SLC39A3 IGFBP1 ABCG8 ABCG5 HGF AIP ALDH3A1 SCNN1A SQSTM1 SLC27A5 FKBP5 FTL SLC26A2 ABHD2 BHLHB2 GSTT2 CYP2C19 FOXO1 SLCO1B1 DKFZp686D0714 PLTP IP6K3 TGFB1 DNAJC15 CYP4F12 IL2 NFKB2 SLC2A9 GCLC CDK4 SP1 MAFF SPINK13 DKFZp686C06176 FGF13 GCLM NFE2L2 HSP90AB1 ALAS1 SRXN1 TNFAIP3 SLC2A2 DBI SLC2A3 NR1C1 SLC2A4 SLC2A6 NR1C2 SLC2A7 SLC2A8 THBD ARL5B CPT2 ZIC2 ME1 PDE4B POLK SRGN GPX2 ABCC2 UGT1A1 GPX3 CYP4A11 HEL-S-25 APOA2 APOA1 NRG1 HEL-S-22 SMC1A APOA5 TGFBR2 TGFBR3 DNAJC7 NAV3 ACOX1 ADGRF4 EHHADH UGT2B4 UGT2B7 BIRC2 BIRC3 SRC SLC5A12 SLC5A10 CYP3A4 CYP3A7 PRRG4 DNAJB1 STOM UGT1A4 CCL2 HES1 UGT1A3 UGT1A9 hCG_1991559 UGT1A7 PPP1R14C APOC3 SCD ALOX5AP BAX S100P SPRY1 ESTROGEN SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP712%HOMO SAPIENS Estrogen signaling pathway MAP2K1 CHUK BRAF FOS MAPK14 NFKB1 GNGT1 IKBKB MAPK9 PIK3CA GNB1 JUN BCL2 GPER MAPK1 IKBKG CREB1 SP1 GNAS FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20220510%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH3A2 CS ACSS2 ALDH2 ACO2 ALDH9A1 THERMOGENESIS%WIKIPATHWAYS_20220510%WP4321%HOMO SAPIENS Thermogenesis MAPK14 ATF2 raptor KDM1A PRKAG1 PRKAG2 FGF8C PRKAG3 ACTG1 DKFZp686M02159 RPS6KA3 RPS6KA6 PS1TP5BP1 RPS6KA2 DPF1 RPS6KA1 MLST8 DPF3 PRKG2 HRAS PRKG1 PPARGC1A MAP3K5 MAP2K3 SMARCC1 PRKAB2 SMARCC2 ACTL6B ACSL1 ACTL6A ADRB3 RPS6 FACL4 ACSL5 TSC2 SIRT6 FRS2 TSC1 ACSL3 CPT1C CNR1 ARID1A ARID1B PRKAB1 ADCY3 ZNF516 AKT1S1 PPARG PLIN1 SOS1 ADCY6 SOS2 MGLL SMARCD1 CREB3L3 SMARCD2 CREB3L4 KDM3A PRKACG PRKAA1 KDM3B DKFZp686N2325 SMARCD3 PRKAA2 UCP1 ADCY1 ADCY8 CPT2 HEL-S-7a SLC25A29 NRAS PRDM16 SLC25A20 SMARCE1 CREB3 BMP8A BMP8B ADCY9 GCG CREB1 MTOR SMARCA4 GNAS MAPK13 MAPK11 RPS6KB1 RHEB CREB5 RPS6KB2 KRAS GRB2 FGFR1 PNPLA2 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20220510%WP51%HOMO SAPIENS Regulation of actin cytoskeleton PIK3R2 PIK3R1 PIK3R5 HEL-S-15 RRAS PIP5K1A CD14 PIP5K1C FGF23 MYH10 FGF22 RDX RASSF7 ARPC5 SSH2 GNG12 SSH3 FGF1B FGF1A SSH1 FGFR4 FGFR3 FGFR2 BRK1 PIK3CD PIK3C2G PIK3C2A STM7 PIK3C2B BDKRB2 TMSB4X BDKRB1 PIP5KL1 RAC3 RAC1 APC2 ITGA1 RRAS2 FGF7B F2 VAV1 FGF7A ARHGEF1 CRK DOCK1 ROCK1 ROCK2 WAS FGF6B FGF6A FGD1 CDC42 GNA13 PAK1 PAK6 CSK WASF1 MAPK6 WASF2 MAPK4 MAPK3 PAK4 EGF FGF13 LIMK1 DKFZp666O0110 FGF5C FGF5B FGF5A BAIAP2 MOS ARHA APC ABI2 MAP2K1 BRAF PIK3CA MAPK1 FGF8C ACTG1 PS1TP5BP1 SOS1 SOS2 FGF8A NRAS CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 KRAS FGFR1 CYFIP2 NCKAP1 F2R FGF4B HEL114 FGF4A KIAA0142 FGF2 ARHGAP35 FGF4C MYLK DKFZp434G2016 FGF8 CFL2 PIP4K2A PIP4K2B hCG_1991735 HEL70 PDGFRA MAP2K2 EGFR ACTN1 MYL1 MYL3 RAF1 PFN1 EZR PXN PIK3R4 PDGFA PIK3R3 NO/CGMP/PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20220510%WP4008%HOMO SAPIENS NO/cGMP/PKG mediated neuroprotection CAMK2D NFKB1 GUCY1B1 CAMK2A RELA CASP9 NPPB NPPA BCL2 TNF-alpha CNGA1 NEFL CNGA3 CNGA4 CAMK2G GUCY1A2 PBR NOS2 BAD PDE2A GRIN2B CREB1 GRIN1 NFKBIA DLG4 AKAP9 PDE3A CNGB3 CYCS CALM3 CALM2 CNGB1 PRKG2 IL1B IF2F CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20220510%WP530%HOMO SAPIENS Cytokines and inflammatory response IL12B TNF-alpha IL11 CSF3 CSF2 CSF1 IF1DA1 CXCL1 CXCL2 IL10 IL15 IL13 IL1B IL4 IL3 IL1A IL6 IL5 IL7 TGFB1 HLA-DRA HLA-DRB1 IL2 IF2F PDGFA RAC1/PAK1/P38/MMP2 PATHWAY%WIKIPATHWAYS_20220510%WP3303%HOMO SAPIENS RAC1/PAK1/p38/MMP2 pathway ANGPT4 PIK3R1 STAT5B STAT3 ANGPT2 CHUK ANGPT1 PTPN11 RAD51 MAPK14 TNIP2 NFKB1 TNIP3 CTNNB1 IKBKB MAPK9 PIK3CA MAPK1 IKBKG DKFZp686M02159 RAC1 HRAS CRK FOXO1 PAK1 MAPK3 DKFZp666O0110 SOS1 RELA CASP9 NRAS NOS2 BAD MAPK13 NFKBIA MAPK11 KRAS GRB2 SRC ITGB1 DKFZp451O0517 RS1 EGFR GRB14 NCK1 MMP2 MSH2 BIRC5 ANGPTL1 GRB7 PXN MAPK8 MYC ERBB2 EIF4EBP1 BAX NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN (NOD) PATHWAY%WIKIPATHWAYS_20220510%WP1433%HOMO SAPIENS Nucleotide-binding oligomerization domain (NOD) pathway CHUK hCG_16983 IKBKB NDUFA13 RELA NOD1 CASP9 PRDM1 NOD2 NLRC4 MEFV IKBKG PYCARD CASP5 NLRP7 NLRP2 NLRP3 NLRP1 AAMP DUOX2 RIPK2 CARD8 CARD9 NFKBIA ERBIN IL18 CARD6 COPS6 NLRP12 RAC1 ACAP1 AIM2 NLRP10 NAIP IL1B ACTIVATION OF NLRP3 INFLAMMASOME BY SARS-COV-2%WIKIPATHWAYS_20220510%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS-CoV-2 PYCARD TRAF3 NLRP3 NFKB1 IL1B RELA SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20220510%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis ABCA1 NR1H3 MED15 SIRT1 NR1C1 SREBF2 PRKAA1 LDLR HMGCS1 PPARGC1A HMGCR SIRT6 MTOR FASN SCD SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20220510%WP4814%HOMO SAPIENS Somatic sex determination FGF4B DMRT1 DHH FOXL2 GATA4 NR5A1 WT1 SOX8 RSPO1 SRY SOX9 AMH PTGDS WNT4 FRAGILE X SYNDROME%WIKIPATHWAYS_20220510%WP4549%HOMO SAPIENS Fragile X syndrome CNR1 CAMK2A GRIN2B CREB1 GRIN1 DLG4 SRC MAP2K1 BRAF PTPN11 MAPK1 ALDH3A2 raptor MLST8 TSC2 APP SH3GL3 EIF4A1 TSC1 CYFIP1 FMR1 ARAF ABAT GRIP1 SYNGAP1 DEPTOR AKT1S1 DAG1 AP2M1 SH3GL1 SOS1 EPHA4 PRKCA DICER1 GRIP2 SLC6A1 GABRG2 EEF1A1 ARC PRKAR1A MAP1B GRIA2 SHC1 AGAP2 RAP1GAP CLTCL1 EIF4EBP2 HOMER1 BDNF AGO2 NF1 EIF4G1 DKFZp434N101 GABRB2 MTOR ABCD3 KCNC1 CLTC CLTB RPS6KB1 RHEB PTEN CLTA AP2A1 KRAS GRB2 GPHN PPP3CA DLGAP3 CYFIP2 DUSP3 KCND2 PPP2R5B MMP9 TTI1 ALDH5A1 TBC1D7 PICK1 PLCB1 SHANK1 AKAP5 MKNK1 AP2S1 EPS8L1 FYN EIF4E NTRK2 CDKN2A MAP2K2 GAD1 TARBP2 DKFZp451F1115 CAMK4 RAF1 CAMK1 PTPN5 HCN1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20220510%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20220510%WP4149%HOMO SAPIENS White fat cell differentiation RORA PPARG GATA3 STAT5B GATA2 INS CTNNA1 NR1H3 EVI1 ZNF423 TLE3 WNT10B TCF7L1 EGR2 NR2F2 KLF4 KLF15 KLF2 KLF5 NR3C1 IRF4 DDIT3 RARA CREB1 FOXO1 IRF3 CEBPA CEBPB CEBPD MAMMARY GLAND DEVELOPMENT PATHWAY - EMBRYONIC DEVELOPMENT (STAGE 1 OF 4)%WIKIPATHWAYS_20220510%WP2813%HOMO SAPIENS Mammary gland development pathway - Embryonic development (Stage 1 of 4) TNF-alpha TGFB1 CCND1 ITGB1 CLDN4 ZEB2 SFRP1 NRG3 TERT ERBB4 ALPL ITGA6 MYC LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2874%HOMO SAPIENS Liver X receptor pathway NR1H3 CYP7A1 CYP2B6 RXRA FASN ABCG8 SCD ABCG5 CYP3A4 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2877%HOMO SAPIENS Vitamin D receptor pathway CD14 FGF23 KLF4 IRF4 CCND1 SFRP1 ADRA1B STEAP4 LPGAT1 IGFBP1 CCNC BDKRB1 GXYLT2 CLDN2 SLC8A1 STS SALL4 TNFSF11 DKFZp727E011 LGALS9 EPHB4 KRT71 SLC34A2 IGFBP5 S100A2 MED9 CDKAL1 FOXO1 HNF1A LCE1F LCE1D LCE2B CDC34 TGFB1 CCNE1 NINJ1 S100A6 S100A4 PRKCQ S100A9 S100A8 TNLG2B COL13A1 CLEC16A TNFRSF11B EFNA5 HIF1A KNG1 KLK6 CYP27B1 CRACR2A CRACR2B TNFAIP3 DND1 BTLA KRTAP4-1 HLA-DQA2 HLA-DQA1 SLC2A4 KL SLC37A2 NR1C2 KRTAP12-2 GADD45A KRTAP8-1 THBD NFATC2 BMP6 BCL6 TRPV6 CYP2S1 PNOC ID1 CDK2 TRPV5 ID4 ALPI CLPTM1L MXD1 ALPG ZNF257 SPRR1B CD200 ORM1 CDKN1A CD40 ITGAM IL25 HILPDA ORM2 TREM1 CASP14 ADAMTS5 SULT1C2 DUSP10 ADGRE5 DACT2 SOSTDC1 CTLA4 TIMP3 CYP3A4 CA9 KRTAP5-1 HLA-DRB1 ABCD1 CAMP KRTAP5-4 KRT34 CEACAM1 KRT38 IRF8 IRF5 DEFB4B COLEC11 PTH SATB1 MYC HEL57 SEMA3B LRP5 ASAP2 IL12A CST6 PTHLH JUNB IL1RL1 SULT2A1 CST1 BGLAP CLMN ALOX5 HSD17B2 CREG2 SPP1 PRDM1 LRRC25 CDKN2D KRTAP10-2 S100G CDKN2B CASP5 CDKN2C KRTAP10-7 CDX2 KRTAP10-9 MX2 ABCB1 KRT13 G0S2 MYO9B ATP2B1 CYP24A1 KRT16 CYP2B6 CYP2C9 PTGER4 CYP1A1 CDKN1B DNER ADRB2 CYP7A1 CDKN2A RXRA CEBPA NR1i1 SARS-COV-2 AND COVID-19 PATHWAY%WIKIPATHWAYS_20220510%WP4846%HOMO SAPIENS SARS-CoV-2 and COVID-19 pathway TLR7 FURIN ACAT1 SLC6A19 SCARB1 NRP1 CTSL ACE2 TMPRSS2 TOLL-LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP75%HOMO SAPIENS Toll-like receptor signaling pathway IL12B PIK3R2 PIK3R1 IL12A MAP2K1 PIK3R5 CHUK FOS CD14 MAPK14 NFKB1 hCG_16983 IKBKB MAPK9 PIK3CA SPP1 TNF-alpha MAPK1 IKBKG PIK3CD IFNA4 IFNA1 TBK1 IF1AA3 DKFZp686M02159 IKBKE IF1AA1 RAC1 TLR7 IFNAR2 IF1AA6 CXCL9 IFNA13 CD80 IF1AA5 AKT3 IF1DA1 MAP3K8 IF1AA4 LBP IFNA14 MAP3K7 STAT1 MAP2K4 TICAM2 IF1AA9 MAP2K3 IRAK4 TIRAP IF1AA8 TLR1 JUN TICAM1 TRAF6 IRF7 TLR9 IRF3 TLR8 TRAF3 TLR5 TLR4 IF1AB4 LY96 TLR3 IRAK1 IFNAR1 CCL5 CCL4 IF1AB1 CCL3 RIPK1 FADD MAPK3 MAP2K6 MAPK10 MAP3K7IP1 CXCL10 CXCL11 IL8 TAB3 MYD88 NFKBIB RELA MAPK13 NFKBIA MAPK11 CD40 IL1B IL6 MAP2K2 IRF5 MAPK8 PIK3R3 ENDOMETRIAL CANCER%WIKIPATHWAYS_20220510%WP4155%HOMO SAPIENS Endometrial cancer PIK3R2 PIK3R1 MAP2K1 CTNNA1 BRAF FOS CTNNB1 TCF7L1 PIK3CA MAPK1 CCND1 FGFR3 FGFR2 PIK3CD APC2 AKT3 HRAS GADD45B MAPK3 ARAF EGF SOS1 SOS2 GSK3B DKFZp586H0919 APC FOXO3A PDPK1 AXIN1 AXIN2 HEL-S-28 CASP9 DDB2 CTNNA3 GADD45A BAK1 CTNNA2 TCF7L2 GADD45G NRAS POLK BAD PTEN KRAS CDKN1A GRB2 FGFR1 FGF2 MAP2K2 EGFR RAF1 MYC ERBB2 PIK3R3 BAX FLAVAN-3-OL METABOLIC PATHWAY%WIKIPATHWAYS_20220510%WP4238%HOMO SAPIENS Flavan-3-ol metabolic pathway HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20220510%WP186%HOMO SAPIENS Homologous recombination POLD3 RAD52 POLD4 RAD50 RAD51 POLD2 RPA1 MRE11A ATM NBN BRCA2 RAD54B ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20220510%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL GPT AGXT ASPA GAD1 ASS ABAT PC GOT2 GAD2 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20220510%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B MAP3K1 ARHA FGF4B FRAT1 AXIN1 CTNNB1 ROCK1 FOXL2 MAPK1 GADD45G SRY SOX9 WNT4 FGFR2 MAPK11 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20220510%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation RIOK3 XB GATA2 MHC2TA FLI1 KLF1 FOS ARHH GP9 KITLG FOSB VAV1 CXCR4 DKFZp586H0919 NFATC2 CSF3 CSF2 CSF1 SPI1 THRB EPO ITGB3 ITGA2B IL1B IKZF1 LYL1 IL3 HMGN5 IL1A TRIM29 IL6 MYB IL5 PIM1 CD34 HES6 LMO2 CBFA2T3 RUNX1 ZNF835 NOTCH1 ACVR1B IRF5 GATA1 ABO TPO MUC1 MXI1 NCKAP1L NFE2 EGF/EGFR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP437%HOMO SAPIENS EGF/EGFR signaling pathway PIK3R2 PIK3R1 STAT3 HEL-S-15 FOSB ATF1 USP6NL ERRFI1 INPPL1 CBLC PEBP1 CRKL RPS6KA5 GRB10 PLCE1 RALBP1 PRKCI MEF2C PRKCB HGS STAMBP RIN1 STAM2 STXBP1 SH2D2A PIK3C2B TWIST1 FOXO4 PRKCZ PLD2 RAC1 JAK1 ATXN2 RAP1A INPP5D COX2 CXNK2 MAP2K5 VAV1 CAV2 TNK2 ARHGEF1 STAT1 PTK6 CRK SYNJ1 NCK2 ROCK1 FOXO1 MYBL2 MAP4K1 VAV3 GAB2 EPS15L1 DKFZp686K0257 CDC42 EPN1 VAV2 PAK1 PLSCR1 PXDN CSK ARF6 RALA RALB SP1 PCNA MAPK4 NEDD8 ASAP1 CBL EGF AURKA DKFZp686B23205 DKFZp666O0110 MAPK7 REPS2 PTK2B RICTOR MEF2D MAP3K2 LIMK2 ITCH NEDD4 SPRY2 CAMK2A CREB1 RAB5A SRC NCK1 MAPK8 ERBB2 EIF4EBP1 STAT5B MAP2K1 BRAF PTPN11 FOS MAPK14 NDUFA13 MAPK9 MAPK1 RPS6KA3 RPS6KA2 RPS6KA1 HRAS JUN JUND SH3GL3 AP2M1 SOS1 SOS2 PRKCA PDPK1 SHC1 DKFZp434N101 MTOR RPS6KB1 PTEN AP2A1 KRAS GRB2 MAP3K1 AP2S1 hCG_1991735 MAP2K2 EGFR RAF1 PTPN5 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20220510%WP4191%HOMO SAPIENS Caloric restriction and aging SIRT1 MTOR PBEF1 PPARGC1A IGF1 PRKAB2 CELL-TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20220510%WP3679%HOMO SAPIENS Cell-type dependent selectivity of CCK2R signaling CCK GNAI1 CCKBR RYR3 CNR1 RYR1 PLCB1 RYR2 DAGLA TRPC1 GNAQ BMP2-WNT4-FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20220510%WP3876%HOMO SAPIENS BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation CTNNB1 FOXO1 SMAD1 SMAD9 DKK1 SFRP1 WNT4 DCN BMP2 BCL2L11 SST DKFZp781O1323 LEFTY2 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20220510%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IL8 MYD88 CHUK NFKB1 IKBKB TNF-alpha IKBKG NFKBIA TRAM1 TBK1 IRAK3 IKBKE INPP5D IF1DA1 MAP3K7 IRAK4 TIRAP TICAM1 IL6 TRAF6 IRF7 IRF3 TRAF3 TLR4 IRAK1 RIPK1 MAP3K7IP1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2879%HOMO SAPIENS Farnesoid X receptor pathway NR1H4 BAAT SLC27A5 FKBP5 SULT2A1 UGT2B4 PPARGC1A FGF8A CYP3A4 IP6K3 ABCB11 NR0B2 CYP7A1 SLCO2B1 ABCB4 RXRA RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20220510%WP2290%HOMO SAPIENS RalA downstream regulated genes RAC1 EXOC2 CDC42 NRAS RALBP1 RALA HRAS CSDA EXOC8 RAC3 KRAS NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20220510%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease PIK3R2 PIK3R1 INS NR1H4 NR1H3 TNF-alpha DDIT3 PIK3CD RAC1 COX2 TGFB1 CDC42 ITCH NR1C1 RELA BCL2L11 CYCS NDUFA11 NDUFA12 IRS1 NDUFA10 COX6A1 COX6A2 NDUFC2-KCTD14 LEPR IL6R SDHC SDHD SDHA COX6B2 IL1A SDHB IL6 COX6B1 ERN1 COX7A2L UQCRC1 UQCRC2 ATF4 UQCRB CCL2 NDUFB10 NDUFB11 COX7A2 ADIPOR1 COX7A1 ADIPOR2 UQCRH SOCS3 MAPK8 COX3 COX1 BAX CYC1 NDUFV3 NDUFV2 NDUFV1 XBP1 VCAM1 INSR EIF2S1 NFKB1 COX7B2 hCG_16983 MLXIPL IKBKB NDUFA13 TNFSF6 MAPK9 UQCRQ PIK3CA CYTB MAP3K11 GSK3A COX7B COX4I1 COX4I2 COX7C BBC3 TMEM49 CASP3 MLX UQCRFS1 COX8A PRKAG1 COX8C PRKAG2 LOC56901 NDUFC2 PRKAG3 TRAF2 NDUFC1 TNFRSF1A NDUFS8 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 AKT3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 MAP3K5 NDUFB4 NDUFB3 NDUFB2 PRKAB2 JUN NDUFB1 UQCR11 UQCR10 COX5A NDUFA9 MLXIP NDUFA7 NDUFA6 NDUFA5 PKLR ZNF183 NDUFA4 NDUFA3 NDUFA2 COX6C UQCRHL PRKAB1 DKFZp781H1925 LEP NDUFAB1 IL8 FAS GSK3B PRKAA1 PRKAA2 BAK1 IL1B RXRA CYP2E1 CEBPA PIK3R3 RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS)%WIKIPATHWAYS_20220510%WP4756%HOMO SAPIENS Renin-angiotensin-aldosterone system (RAAS) ATF6B CALML6 ITPR2 CALML3 CALML4 CREB3L3 CYP11A1 CAMK2D CREB3L4 CTSG CAMK1D ATF1 CAMK2A CMA1 DKFZp686N2325 HSD3B1 STAR CYP21A2 CYP11B2 REN GNAQ PLCB2 CAMK1G CAMK2G CREB3 ATF2 CREB1 CREB5 CALM3 CALM2 HSD3B2 ATF4 AGTR1 CAMK4 AGTR2 CAMK1 SARS-COV-2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20220510%WP5183%HOMO SAPIENS SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction RPS6KA1 NFKB1 TNF-alpha IL6 TRAF6 REN ACE2 MAVS TOMM70 NDFIP2 TRAF3 NLRX1 ACAD9 NLRP3 ECSIT SIRT6 MITA TERF2 NDUFAF2 TERF2IP NDUFAF1 IL18 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20220510%WP2064%HOMO SAPIENS Neural crest differentiation ASCL1 HDAC9 HDAC7 DLL3 DLL4 PRTG GBX2 MITF-C NFKB1 DVL1 CTNNB1 DVL2 TCF7L1 MBP MSX1 WNT1 HES5 TFAP2A TFAP2B FZD3 WNT3A ZIC5 DKFZp566E044 TBX6 PHOX2B FGFR3 GFAP FGFR2 BMP4 CXNG TLX2 LHX1 PMP22 SNAI1 TWIST1 TCF4 LHX5 NEUROG1 SOX9 NFKB2 SNAI2 GSK3B AXIN1 AXIN2 FGF8A SMAD1 ID1 HDAC10 HDAC11 RBPJ DKFZp586M1622 DMBX1 CDH6 CDH2 FGFR1 MPZ ZIC1 HEY2 HOXA1 SOX5 FOXD3 MSX2 FGF2 OLIG3 PAX3 OLIG1 OLIG2 ISL1 FGF8 SOX10 MYB RHOB COL2A1 PAX7 HAND1 ITGB1 DKFZp434N181 HOXB1 HDAC4 HDAC5 HES1 NOTCH3 NOTCH1 HDAC2 HDAC3 CTBP2 DLX5 HDAC1 COL11A2 MYC WNT8A HDAC8 AMINO ACID METABOLISM PATHWAY EXCERPT: HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20220510%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt: histidine catabolism extension GLUD1 HAL UROC1 GPT2 FTCD MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20220510%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3R2 PIK3R1 STAT3 MAP2K1 SOS1 SOS2 PTPN11 BRAF PIK3CA MAPK1 CRKL NRAS BAD DKFZp434N101 PIK3CD HGF KRAS CDKN1A RAC1 GRB2 RAP1A ALK AKT3 PRCC RPL11 ELOA HRAS INSL3 CRK JAK3 C8orf34 SRC RAPGEF1 JUN STRN CDC42 PAK1 PAK6 MAP2K2 RAF1 MAPK3 ARAF PAK4 CBL MAPK8 DKFZp666O0110 PIK3R3 MYD88 DISTINCT INPUT-OUTPUT PATHWAY%WIKIPATHWAYS_20220510%WP3877%HOMO SAPIENS MYD88 distinct input-output pathway TLR7 MYD88 NFKB1 JUN TLR1 IL1A HEL-S-71 TRAF6 TIFA TLR9 TLR10 TLR8 UBE2V1 TLR5 TLR4 IRAK1 HEROIN METABOLISM%WIKIPATHWAYS_20220510%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 TCA CYCLE (AKA KREBS OR CITRIC ACID CYCLE)%WIKIPATHWAYS_20220510%WP78%HOMO SAPIENS TCA cycle (aka Krebs or citric acid cycle) SDHC SDHD SDHA SDHB CS DKFZp564P2062 FH ACO2 MDH2 IDH3B OGDH SUCLG2 SUCLG1 DLD NETRIN-UNC5B SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4747%HOMO SAPIENS Netrin-UNC5B signaling pathway CTGF PPP2R1B PTK2B KDR MAP2K1 NEO1 PLEKHH1 PRKCA PTPN11 ARHA ARHGEF12 VCAM1 UNC5B MAPK14 CIP2A SELE RGMA COL1A1 DCSTAMP PIK3CA MYF5 TNF-alpha AGAP2 MAPK1 CASP3 ALPL RAC1 INPP5D IL10 SRC JUN IL1A FYN DKFZp451O0517 CCL2 MAP2K2 PTPA RAF1 MAPK3 ROBO4 ITGB4 NTN1 RLF DKFZp666O0110 NTN3 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20220510%WP5174%HOMO SAPIENS Ulcerative colitis signaling GATA3 NFKB1 IL10 IL13 IL4 NFATC1 NOD2 TNF-alpha IL2RG FOXP3 IL5 HLA-DMA TGFB1 MAF STAT6 IF2F TARGET OF RAPAMYCIN (TOR) SIGNALING%WIKIPATHWAYS_20220510%WP1471%HOMO SAPIENS Target of rapamycin (TOR) signaling RICTOR PRKCA PRKAA1 PRKAA2 MAPKAP1 hCG_2039433 DDIT4L FKBP1A raptor RRAGA MTOR RRAGB PRKAG1 DDIT4 PRKAG2 RRAGD ULK2 PRKAG3 RPS6KB1 ULK1 RHEB RAC1 MLST8 IDI1 PRKAB2 HMGCR CDC42 TSC2 TSC1 PRKAB1 EIF4EBP1 AKT1S1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20220510%WP4971%HOMO SAPIENS Phosphoinositides metabolism PIP5K1A PIP5K1C PIK3CA PLCB2 PLCE1 DKFZp434N101 PIK3CD PIK3C2G PIK3C2A STM7 PIK3C2B MTMR1 PTEN MTMR2 MTMR10 MTMR3 MTMR12 MTMR11 MTMR8 INPP5D MTMR9 MTMR4 MTMR6 MTM1 PIP4P2 PIP4P1 PLCZ1 PLCG2 PLCB1 SBF1 SBF2 SACM1L OCRL PIP4K2A PIKFYVE PIP4K2B PLCB3 PLCB4 PLCH1 PLCH2 PLCD3 PLCD4 PIK3R4 SPHINGOLIPID METABOLISM: INTEGRATED PATHWAY%WIKIPATHWAYS_20220510%WP4726%HOMO SAPIENS Sphingolipid metabolism: integrated pathway CERS3 hCG_2045882 CERS5 CERS6 SPHK2 SPHK1 MGC26963 SGPP2 SGPP1 PPAP2A DEGS1 DEGS2 PLPP3 PLPP2 CERS1 CERS2 SGMS1 CERK UGCG UGT8 SGPL1 SPTLC1 SPTLC2 SMPD1 KDSR ATR SIGNALING%WIKIPATHWAYS_20220510%WP3875%HOMO SAPIENS ATR signaling hCG_37731 TREX1 CHEK1 HUS1 TOPBP1 RAD9B RPA1 ATR RAD9A IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20220510%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia CDKN1B ABCG2 FOXO3A GADD45A LYL1 GAB2 PIM1 PDGFRA ABCB1 CSF1R FLT1 NOP2 BCR KIT PIM2 MYC SKP2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20220510%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway IDI2 ACAT2 ACAT1 HMGCL FDPS IDI1 MVK HMGCS1 HMGCR PMVK MVD FDFT1 GGPS1 BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2380%HOMO SAPIENS Brain-derived neurotrophic factor (BDNF) signaling pathway PIK3R2 PIK3R1 STAT3 HEL-S-15 EGR2 RPS6KA5 MEF2C ALPL RAC1 RAP1A SQSTM1 MAP2K5 STAT1 NCK2 VAV3 CDC42 VAV2 CNR1 MAPK3 MAPK7 PTK2B MAP3K2 APC CAMK2A RELA BAD BMP2 BCL2L11 GRIN2B CREB1 GRIN1 NFKBIA IRS1 SRC NCK1 IGF2BP1 MAPK8 EIF4EBP1 STAT5B MAP2K1 CHUK PTPN11 FOS MAPK14 EIF2S1 NFKB1 CTNNB1 IKBKB MAPK9 SPP1 MAPK1 IKBKG CASP3 RPS6KA3 RAB3A NCF1 RPS6KA1 CRTC1 NCF2 SIRPA CDKL5 HRAS CSNK2A1 FRS3 TIAM1 EGR1 ADAM17 DOK5 JUN SHC4 TRAF6 SHC2 SHC3 ACACB RPS6 KCNN2 GRIA3 NGFR TSC2 EIF2S2 NFATC4 FRS2 CDK5 GABRB3 CYFIP1 DOCK3 RASGRF1 YBX1 PTPRF MAPK10 GRIP1 KSR1 NGF SYN1 KCNA3 PPP2CA NTF3 NCAM1 GSK3B SH2B2 SH2B1 FOXO3A NTRK1 PDPK1 LINGO1 PRKAA1 KIDINS220 SORT1 NTRK3 PRKAA2 RANBP9 GRIA2 ARHG SHC1 MARCKS CDK5R1 BDNF DKFZp434N101 MTOR RPS6KB1 GRB2 CDH2 MAP3K1 FYN EIF4E NTRK2 MAP2K2 CAMK4 RAF1 CAMK1 CANONICAL NF-KB PATHWAY%WIKIPATHWAYS_20220510%WP4562%HOMO SAPIENS Canonical NF-kB pathway NFKBIE CHUK NFKB1 IKBKB NFKBIA RELA REL IKBKG FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20220510%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA5 LIPC SEL1L LPL APOA4 LMF1 GPIHBP1 LDLR APOA2 APOA1 PLTP DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20220510%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte PPARG PPARGC1B ZIC1 ZNF423 PPARGC1A PRDM16 SMAD1 SMAD9 EVA1 BMP4 BMP2 DGIC HSPB7 CEBPG DKFZp781O1323 CIDEA EBF3 CEBPA SLC7A10 CEBPB LEP HOXC9 HOXC8 ARACHIDONATE EPOXYGENASE / EPOXIDE HYDROLASE%WIKIPATHWAYS_20220510%WP678%HOMO SAPIENS Arachidonate epoxygenase / epoxide hydrolase COX5A CYP2J2 CYP2C8 EPHX2 COX8A CYP2C9 HEL-S-22 TYROSINE METABOLISM%WIKIPATHWAYS_20220510%WP4506%HOMO SAPIENS Tyrosine metabolism HPD FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20220510%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation PPP2CA MAP2K1 PTHLH MAPK14 MAPK1 FGFR3 BMP4 BMP2 MAPK13 MAPK11 SNAI1 DKFZp686M02159 CDKN1A THRA FGF4B CNP NPR2 IHH STAT1 PTH1R ATG5 RBL1 FGF6A SOX9 MAP2K2 RAF1 MAPK3 NEOVASCULARISATION PROCESSES%WIKIPATHWAYS_20220510%WP4331%HOMO SAPIENS Neovascularisation processes CXCR4 KDR ANGPT1 DLL4 NFKB1 KITLG RELA MAPK9 MAPK1 REL SMAD1 SMAD9 DKFZp781O1323 KIT EPHB4 MMP9 ACVRL1 FLT4 RELB EPHB2 SMAD2 TGFB1 TGFBR1 CXCL12 NFKB2 NOTCH3 NOTCH1 MAPK3 MAPK8 HIF1A INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20220510%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway FGF5B SIRT1 COL2A1 TGFB1 CDC37 DDR1 SUV39H1 LOXL4 ECSIT NRF1 PKD1 BMP2 EXOC6 IGFBP7 HEL-S-7 NQO1 NFE2L2 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20220510%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases HEL74 UMPS OTC DPYS TYMS TYMP RRM1 RRM2 GLS2 CAD NT5C3 DHODH DPYD RRM2B GLUTATHIONE METABOLISM%WIKIPATHWAYS_20220510%WP100%HOMO SAPIENS Glutathione metabolism HEL-S-64p GPX1 GPX4 IDH1 OPLAH HEL-75 GSTA5 GGTLA4 GGTLC2 GSTT2 GSTM2 GSTM1 GPX2 GCLC GPX3 GCLM PHYSICO-CHEMICAL FEATURES AND TOXICITY-ASSOCIATED PATHWAYS%WIKIPATHWAYS_20220510%WP3680%HOMO SAPIENS Physico-chemical features and toxicity-associated pathways MAP2K1 GPX1 NEF3 FZD10 DVL1 CTNNB1 NEFH ACTR3 ACTR2 WNT16 ACTA1 DAAM1 MAPK1 PFN4 PFN3 FZD3 PFN2 WNT11 FZD1 FZD2 FZD5 FZD4 FZD7 ERBB4 FZD9 FZD8 HEL-S-44 TGFA TMSB4X MAP2K4 ROCK2 JUN PAK1 CBL DKFZp666O0110 PPP2CA SOS1 GSK3B CDKN1B ARHA APC AXIN1 SHC1 NEFL DKFZp434N101 CDKN1A GRB2 MYLK SRC EGFR NCK1 MYL1 RAF1 CAMK1 PFN1 MAPK8 MYC ERBB2 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20220510%WP4271%HOMO SAPIENS Vitamin B12 disorders TCN1 CBLIF MMAB MTR MMACHC MMADHC CD320 CUBN AMN MTRR MMAA TCN2 TRANSCRIPTION CO-FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20220510%WP4533%HOMO SAPIENS Transcription co-factors SKI and SKIL protein partners NF1 TEAD4 SKI LATS1 HDAC3 LATS2 SIN3A HDAC1 MERTK SKIL TEAD2 TEAD3 THYMIC STROMAL LYMPHOPOIETIN (TSLP) SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin (TSLP) signaling pathway IL8 STAT5B STAT3 MAP2K1 PTPN11 MAPK14 NFKB1 RELA MAPK9 PIK3CA MAPK1 STAT6 MTOR NFKBIA JAK1 STAT1 SRC RELB IL6 GAB2 CCL11 STAT4 FYN LYN RPS6 YES1 CISH MAP2K2 TSLP NFKB2 TEC FES LCK TNLG2B IL2RA MAPK3 BTK IL7R PI4K2A MAPK8 CRLF2 MYC EIF4EBP1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20220510%WP1971%HOMO SAPIENS Integrated cancer pathway BRCA1 BACH1 DKFZp686G14213 CHEK2 CDKN1B BARD1 POU2F1 PLK1 MSH6 NOXA1 ATF1 hCG_16983 MDM2 CASP9 BCL2 CDKN2B CHEK1 BBC3 RAD50 CASP3 CDK2 BAD ATR MRE11A ATM PTEN CDKN1A JAK1 STAT1 MAP3K5 SMAD2 CDC2 CDK4 MSH2 RB1 MYC BLM BAX BENZENE METABOLISM%WIKIPATHWAYS_20220510%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH NQO1 CYP2E1 MPO GSTM1 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20220510%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma JAK1 IL11 STAT3 NFKB1 IL6R JAK3 RELA hCG_2011440 IL6 IL6ST SOX4 SECRETION OF HYDROCHLORIC ACID IN PARIETAL CELLS%WIKIPATHWAYS_20220510%WP2597%HOMO SAPIENS Secretion of hydrochloric acid in parietal cells GAS DKFZp666G172 CCKBR CHRM1 HRH2 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20220510%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK PDHA1 TPK1 HEL107 SLC19A3 OGDH DKFZp667O1614 SLC19A2 PROTEASOME DEGRADATION%WIKIPATHWAYS_20220510%WP183%HOMO SAPIENS Proteasome degradation PSMC4 PSMA2 PSMC1 PSME2 HEL-117 UBE1 NEDD4 H2AX PSMD10 PSMD12 PSMD11 HEL-S-276 HEL-S-91n UBA7 RPN2 PSMD13 UBE2D2 UBE2D3 RPN1 UBE2D1 PSMB10 PSMB6 PSMD9 PSMD6 PSMD7 PSMD4 PSMB2 UBB PSMD5 PSMB3 PSMD2 UBC PSMD3 PSMD1 HIST1H2AB H2AZ1 UBE2B HLA-B HLA-C HLA-A PSM8 HLA-F HLA-G IF2F HEL-S-283 HLA-E PSMA4 PSMC6 NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%WIKIPATHWAYS_20220510%WP2485%HOMO SAPIENS NAD biosynthesis II (from tryptophan) TDO2 NMNAT1 HEL-S-90n KYNU HAAO AFMID KMO NADSYN1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20220510%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX19 COX7B COX16 TACO1 COX4I1 COX18 COX17 COX7C HIGD1A COX11 COX14 CSRP2BP COX10 COA6 COX8A hCG_16955 SURF1 PET100 FAM36A CMC1 TMEM177 PNKD SCO2 SMIM20 COX2 COX6A1 COX6B1 COX5A COX7A2 NDUFA4 COX6C COX3 COX1 RELATIONSHIP BETWEEN INFLAMMATION, COX-2 AND EGFR%WIKIPATHWAYS_20220510%WP4483%HOMO SAPIENS Relationship between inflammation, COX-2 and EGFR PTGER3 PLA1A BRAF AKT3 HRAS PIK3CA SRC MAPK1 NRAS PTGS2 EGFR PTGER4 PIK3CD MAPK3 PTGER1 PTGER2 KRAS NAD+ METABOLISM%WIKIPATHWAYS_20220510%WP3644%HOMO SAPIENS NAD+ metabolism PARP1 NRK SIRT4 SIRT5 SIRT1 NMNAT3 NMNAT1 NMNAT2 SIRT7 PBEF1 SIRT2 SIRT3 NT5E FLJ13052 SIRT6 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20220510%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II NAA20 AKR1D1 HEL-S-64p UGT2B28 CYP17A1 GPX4 FLJ16008 SULT1E1 CYP2A13 UGT1A5 CYP2F1 GSTA5 AKR1C1 CYP4B1 GSTA4 AKR1C2 GSTA3 HS3ST5 AKR1C4 HS3ST6 FMO4 FMO5 HS3ST4 HS3ST1 HS3ST2 GSTZ1 CYP2W1 CYP20A1 GSTT2 CYP2C19 CYP4F12 CYP27B1 EPHX1 CYP2S1 GPX2 UGT1A1 GPX3 CYP2A6 HEL-S-22 UGT2B4 SULT1C2 UGT2B7 CYP51A1 CYP3A4 CYP3A7 UGT1A4 UGT1A3 UGT1A9 UGT1A7 CYP1B1 SULT2A1 MGST3 MGST1 CYP24A1 MGST2 SULT1A1 CYP2B6 GSTM3 UGT1A10 GSTM2 TPMT GSTM1 HEL-S-75 CYP46A1 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 DKFZp686I24235 HEL-S-166mP CYP2C9 UGT2B11 UGT2B15 UGT2B17 CYP27A1 SULT2B1 CYP1A2 CYP2U1 CYP1A1 SULT6B1 HS3ST3A1 NNMT GSTM5 CYP4F22 CYP4X1 CHST11 CHST12 CYP11A1 CHST10 CHST13 CHST14 SULT1A2 NAA50 GATF-C GLYATL2 CYP21A2 HEL-S-165mP CYP11B2 CYP4F2 CYP4F3 CYP4F11 CYP4F8 CYP26A1 SULT1B1 AKR1B10 NAT8 NAT2 NAT9 NAT11 AKR1B1 NAT10 NAT14 LOC51064 HS2ST1 SULT1C3 CYP26B1 CYP4V2 CYP2J2 CYP2R1 CYP2C8 HYAL3 EPHX2 UGT2A3 BAAT UGT2A2 UGT2A1 GAL3ST2 HEL-75 GAL3ST3 GAL3ST4 SULT1C4 CHST8 HS3ST3B1 CHST9 CHST6 CHST7 GSTO2 HEL-S-21 CYP3A43 DKFZp667E137 KCNAB1 CYP7B1 CYP7A1 KCNAB3 INMT CYP2A7 CYP26C1 CHST1 CHST4 ST1A5 CYP2E1 NAT8L CHST5 CHST3 HEL-S-75p TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20220510%WP325%HOMO SAPIENS Triacylglyceride synthesis AGPAT4 LIPF GNPAT PNPLA2 AGPS GPD1 GPAM PPAP2A PLPP3 PLPP2 LIPC LPL AGPAT5 DGAT2 DGAT1 MOGAT3 MOGAT2 MOGAT1 AGPAT1 AGPAT2 AGPAT3 4-HYDROXYTAMOXIFEN, DEXAMETHASONE, AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20220510%WP3879%HOMO SAPIENS 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression MAP2K1 HEL164 PRKAA1 MAP3K5 MAP2K3 MAP3K11 MKNK1 MAPK1 EIF4E MAP2K2 TSC1 MTOR RAF1 MAPK3 MAP2K6 EIF4EBP1 SOMATROPH AXIS (GH) AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20220510%WP4186%HOMO SAPIENS Somatroph axis (GH) and its relationship to dietary restriction and aging SIRT1 IGF1R MTOR FOXO1 PTEN LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20220510%WP4478%HOMO SAPIENS LTF danger signal response pathway IL8 MYD88 IF1DA1 TREM1 CD14 HEL110 NFKB1 IL1B IRAK4 IL1A TNF-alpha IL6 TRAF6 MAPK1 TLR4 IRAK1 IFNA1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20220510%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism CYP17A1 CYP11A1 H6PD SRD5A2 HSD3B2 HSD3B1 HSD17B3 HSD11B1 STAR HSD11B2 CYP21A2 POR CYP11B2 16P11.2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20220510%WP4949%HOMO SAPIENS 16p11.2 proximal deletion syndrome NFKB1 HEL-S-90n hCG_16983 NR3C1 TBX6 TRAF2 MAP2K3 SMEK1 TRAF6 DOC2A FAM57B FIMP CCT6B PAGR1 SPN PPP4R1 PPP4R2 PPP2R1A PPP4R4 UNC13B PCNA PARP4 MAPK3 UNC13A MAP2K6 HEL-S-69 PPP2R5D PPP4R3B ASPHD1 TCP1 PPARG KCTD13 PPP2CA ZG16 INO80E HEL-S-87p PAXIP1 KMT2C MVP LOC124446 GDPD3 CORO1A HIRA PPP4C HIRIP3 CCT8 CCT7 REL CDIPT BPTF CCT4 MLL2 PRRT2 SIAH1 HEL-S-100n C16orf54 CCT6A TAOK2 CCDC6 YPEL3 PTEN HEL70 HDAC3 EZR PDGF PATHWAY%WIKIPATHWAYS_20220510%WP2526%HOMO SAPIENS PDGF pathway PIK3R1 STAT3 MAP2K1 SOS1 CHUK PTPN11 ARHA FOS NFKB1 SHC1 MAPK1 DKFZp434N101 NFKBIA WASL RAC1 JAK1 GRB2 COX2 MAP3K1 VAV1 HRAS STAT1 MAP2K4 TIAM1 SRC JUN CDC42 PAK1 VAV2 RAF1 MAPK3 MAPK8 PDGFA P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP400%HOMO SAPIENS p38 MAPK signaling pathway MEF2D MAPK14 SHC1 RPS6KA5 DDIT3 ATF2 CREB1 TRAF2 MAX TRADD HMGN1 RAC1 HEL-S-102 GRB2 MAPKAPK2 MAPKAPK5 MAP3K1 MAP3K7 HRAS STAT1 MAP2K4 MAP3K5 MKNK1 CDC42 TGFBR1 RIPK1 RASGRF1 MAP2K6 MYC GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20220510%WP2363%HOMO SAPIENS Gastric cancer network 2 CTNNB1 DGIC TOP2A OTUD5 AHCTF1 DSCC1 CHTF18 LMNB2 MTDH CHTF8 BRIX1 RFC3 RFC4 UBE2C ATAD2 CACYBP FAM91A1 hCG_2042738 RNF144B LBR UBE2T S100A6 EGFR COL9A1 RAD17 CEBPZ COL9A3 CD48 MYC SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T-CELL POLARIZATION%WIKIPATHWAYS_20220510%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T-cell polarization IL12B CXCR4 IL12A CCR5 CSF2 CCR4 CCR3 CXCR3 CCR2 CCR1 IL4 IL5 TGFB1 IL2 CCL4 CCL3 IFNGR1 IFNGR2 CD40LG IF2F IL12RB1 IL18R1 CCR7 VITAMIN D-SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20220510%WP4698%HOMO SAPIENS Vitamin D-sensitive calcium signaling in depression TPH1 KDM1B CYP27B1 CACNA1C ITPR2 CALB1 KDM6B GPX4 ATP2B4 ATP2B3 KDM3A ATP2B2 KCNQ2 GGTLC2 KCNQ3 PVALB BCL2 CHRM1 KDM1A GRIN2B ATP2B1 GRIN1 SLC8A1 HEL-75 GGTLA4 GCLC RXRA CYP27A1 NR1i1 TPH2 NFE2L2 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20220510%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC9 HDAC7 AHCY ADH1C ADH1B TYMS ADH1A HEL-S-53e SLC19A1 MAT1A ACSS2 DKFZp686G1675 ALDH2 DKFZp566E044 ALDH1A2 HAT1 ATF2 DHFR HDAC10 MTR KAT2B HDAC4 HDAC5 HDAC2 HDAC3 HDAC1 CYP2E1 HDAC8 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20220510%WP1422%HOMO SAPIENS Sphingolipid pathway CERS3 PPP2CA CERS5 CERS6 SPHK2 SPHK1 MGC26963 SGPP2 PPAP2A CERS2 ASAH2 GBA2 SGMS1 ACER1 CERK SPTLC3 UGCG SERINC1 UGT8 CERT1 SGPL1 SPTLC1 SPTLC2 KDSR NRF2-ARE REGULATION%WIKIPATHWAYS_20220510%WP4357%HOMO SAPIENS NRF2-ARE regulation GSK3B PRKCA SLC7A11 INSR HMOX1 PIK3CA SRC EPHB2 MAF FYN YES1 GCLC KEAP1 RBX1 NQO1 AIMP2 MAPK8 PGAM5 CEBPB GCLM NFE2L2 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20220510%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG9 B4GALT1 ALG6 TUSC3 SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 MAGT1 ALG1 ALG11 DPM1 GMPPB DPM2 DPM3 GCS1 MGAT2 MPDU1 DPAGT1 ALG8 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20220510%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity hCG_16983 MBP TNFSF6 PRKCI CASP3 PRKCZ MERTK TGFB1 CX3CR1 PLSCR1 FCN1 FCN2 PROS1 DKFZp666F1010 UNQ172 C4BPA C4BPB CLU C8A CX3CL1 C4A C8G FAS CASP10 ITGAX ITGAV DLGAP5 MBL2 CAP1 CR2 CR1 APAF1 ATP11C CASP9 SCRIB ATP11A PLSCR3 BAK1 PARD3 PLSCR4 TYRO3 SERPING1 MASP2 MASP1 CD46 GAS6 LLGL2 CRB2 CFD COLEC12 CRB1 COLEC10 C1S CFH C1R DIABLO CYCS C5AR1 CFI ITGAM PARD6G HTRA2 ATP10A C4B_2 CFP C2 VTN ITGB3 PARD6B PARD6A C6 C7 C3AR1 C9 CD59 C5AR2 MARK2 DEDD CD55 MARK1 ADIB ADIC ATP8B3 ATP8B2 ADIA ATP8B1 HEL-S-62p AXL COLEC11 IF2F BAX CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20220510%WP2795%HOMO SAPIENS Cardiac hypertrophic response HDAC9 MAP2K1 HDAC7 CHUK MAPK14 NFKB1 IKBKB TNF-alpha MAPK1 IKBKG FGFR2 IKBKE TNFRSF1A RAC1 MAP2K5 MAP3K7 PRKG1 MAP2K4 MAP2K3 MAP4K1 TGFB1 MAPK3 MAP2K6 EGF MAPK7 GSK3B PRKCA PDPK1 CAMK2D IGF1 NPPA NFATC2 MTOR NRG1 CALM3 PPP3CA CALM2 MAP3K1 FGF2 TGFBR1 MAP2K2 HDAC4 HDAC5 RAF1 PRKD1 DKFZp686J04131 MAPK8 PLA2G2A CDK9 CDK7 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20220510%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PTDSS1 HMFN0839 GPAT4 PTPMT1 CEPT1 PIP5K1A GPAT2 hCG_16873 PCYT2 IPMK CRLS1 GPAM PEMT PIK3CA CHPT1 LPIN1 LPIN2 CDS2 CDIPT PIK3CD MOGAT3 GNPAT AGPS GPD1 PI4K2A PLA2G2A HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20220510%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling PTK2B STAT3 MAP2K1 SOS1 PTPN11 FOS PIK3CA MAPK1 CRKL PTEN HGF GRB2 RAP1A ITGA1 HRAS CRK DOCK1 SRC RAPGEF1 MAP4K1 JUN ITGB1 PAK1 MAP2K2 RAF1 MAPK3 PXN MAPK8 DKFZp666O0110 PRADER-WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20220510%WP3998%HOMO SAPIENS Prader-Willi and Angelman syndrome INS MSX1 PCSK1 OXT CDKN2B UBE3A CDKN2C GABRR3 CCND1 NPAP1 PCM1 GABRR1 HERC2 CCND2 BBS4 SNRPN FSHB NIPA1 TACR3 NIPA2 GABRG3 GABRG1 PRKCZ FEZ1 FEZ2 OCA2 MAGEL2 SLC45A2 LHB NHLH2 NDN CGA GABRA5 CDC6 TYR KISS1 POMC CDK6 GHRH TUBGCP5 MKRN3 GNRH1 MDM4 GHRL GABRB3 CDK4 CYFIP1 RB1 NGF GABRG2 MDM2 BDNF ATP10A hCG_2042738 CDKN2A DLX5 T CELL RECEPTOR AND CO-STIMULATORY SIGNALING%WIKIPATHWAYS_20220510%WP2583%HOMO SAPIENS T cell receptor and co-stimulatory signaling CALM3 PPP3CA CALM2 GSK3B PRKCA NFKB1 GSK3A NFATC2 CTLA4 FYN IL2 ITK DYRK2 DKFZp434N101 CSNK1A1 DYRK1A LCK CD8B1 NFKBIA ZAP70 CD8A PTPN6 PTEN PDCD1 HOST-PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES - AUTOPHAGY%WIKIPATHWAYS_20220510%WP4863%HOMO SAPIENS Host-pathogen interaction of human coronaviruses - autophagy ATG10 WIPI1 ZFYVE1 ATG12 MAP1LC3A FLJ10035 RB1CC1 ATG5 MTOR ULK2 ULK1 PIK3R4 FLJ00012 ATG3 EBSTEIN-BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20220510%WP262%HOMO SAPIENS Ebstein-Barr virus LMP1 signaling IL8 CHUK IF1DA1 TRAF1 NFKB1 MAP3K7 PDLIM7 IKBKB RELA TNF-alpha TRAF6 MAPK1 IKBKG NFKB2 IRAK1 CCL5 NFKBIA DKFZp686J04131 MAPK8 TRADD CCL20 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20220510%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases PIK3R2 PIK3R1 PIK3R5 DLL3 DLL4 FZD10 WNT10B WNT1 WNT16 FZD3 WNT3A WNT11 FZD1 PRKCI FZD2 FGFR4 FZD5 FGFR3 PRKCB FZD4 FGFR2 FZD7 BMP4 FZD9 PIK3CD FZD8 PIK3C2G PIK3C2A PIK3C2B PRKCZ FGF7B FGF7A STAT1 FGF6A PRKCQ MAPK6 MAPK4 MAPK3 MAPK7 FGF5C FGF5B FGF5A PRKCH WNT5B PRKCE RUNX2 SMO PRKDC WNT3 JAG2 SMAD4 WNT10A SMAD1 PTCH1 SMAD9 BMPR1A WNT2B BMPR2 BMP2 GLI3 HEY1 WNT9B DKFZp781O1323 WNT9A MYOD1 WNT8B LRP6 HES3 HES2 WNT7B WNT7A MAPK8 LRP5 MAPK14 CTNNB1 MAPK9 PIK3CA MAPK1 DKFZp686M02159 SOX9 WNT4 MAPK10 PPARG PRKCA MAPK13 MAPK11 RBPJ FGFR1 HEY2 FGF4B IHH FGF2 FGF8 HES6 DKFZp434N181 NOTCH3 NOTCH1 PRKD1 PIK3R4 WNT8A PIK3R3 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20220510%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB ITGB5 ITGA1 LAMB2 SDC2 LAMA4 LAMC1 THBS2 THBS1 COL3A1 COL1A2 COL4A2 COL4A1 COL5A3 COL6A1 COL5A2 ITGB6 HOST-PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES - APOPTOSIS%WIKIPATHWAYS_20220510%WP4864%HOMO SAPIENS Host-pathogen interaction of human coronaviruses - apoptosis MAPK14 hCG_16983 APAF1 TNFSF6 CASP9 BCL2 TNF-alpha MCL1 BCL2L1 BBC3 CASP3 BAD BCL2L11 MAPK13 FADD MAPK11 DKFZp686M02159 BAX EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20220510%WP3930%HOMO SAPIENS EDA signaling in hair follicle development EDARADD PTCH1 EDAR DKK4 DKK1 SHH BMP1 TNLG7C LTB SOSTDC1 RELB WNT3 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20220510%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER3 PRXL2B TBXAS1 PTGES ALOX5 GNAQ GNAI1 GNAS MAPK11 CDKN1A SIRT1 HRAS IGFBP5 PLCB1 PTGS2 PTGDS PTGER4 ALOX15 ALOX12 LTC4S PTGER1 ADCY3 PTGS1 RB1 PTGIS ALOX5AP PTGER2 ALOX15B AEROBIC GLYCOLYSIS%WIKIPATHWAYS_20220510%WP4629%HOMO SAPIENS Aerobic glycolysis HEL-S-30 HEL-S-87p PGAM2 HEL-S-133P HEL-S-68p HEL-S-17 PFKM HEL-S-162eP HEL-S-49 APOE AND MIR-146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20220510%WP3926%HOMO SAPIENS ApoE and miR-146 in inflammation and atherosclerosis TLR4 IRAK1 NFKB2 SPI1 RELA APOE TRAF6 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20220510%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology CTGF ADCY6 MAP2K1 SOS1 HEL-S-15 SOS2 ARHA TAFAZZIN ADCY1 SYNE4 ADCY8 SYNE3 MAPK1 SYNE1 HEL-S-7a TMEM43 NRAS BANF1 SMAD4 EMD HEL-S-61 SUN1 LEMD3 YY1AP1 ADCY9 DKFZp686M09200 PLEC KRAS GRB2 HRAS SMAD2 TGFB1 LBR MAP2K2 MAPK3 ADCY3 FOLATE METABOLISM%WIKIPATHWAYS_20220510%WP176%HOMO SAPIENS Folate metabolism GPX1 INS GPX4 INSR NFKB1 AHCY TNF-alpha SLC19A1 MAT1A SERPINA3 SERPINE1 HEL-S-44 HBB SCARB1 PLAT MTRR FLAD1 FGA GPX6 IZUMO1R HBA2 F7 MTR MTHFD1 DKFZp727E011 MTHFD2 ABCA1 F2 HCP1 CRP SHMT1 SAA4 LDLR PLG HEL-S-51e DKFZp564M2422 APOB MTHFS HEL-S-78p CTH ALB SAA1 SAA2 FOLR3 IL2 FOLR2 NFKB2 FOLR1 RELA MPO GPX2 GPX3 DHFR APOA1 CSF1 IL1B IL4 IL6 CCL2 IF2F SARS-COV-2 AND ACE2 RECEPTOR: MOLECULAR MECHANISMS%WIKIPATHWAYS_20220510%WP4883%HOMO SAPIENS SARS-CoV-2 and ACE2 receptor: molecular mechanisms AGTR1 MGRA REN ACE2 TMPRSS2 CELL CYCLE%WIKIPATHWAYS_20220510%WP179%HOMO SAPIENS Cell cycle CCND1 CCND2 EP300 CDC6 CDK6 TGFB1 CCNE1 CDK4 PCNA RB1 DKFZp686G14213 CHEK2 PLK1 MDM2 GADD45A PRKDC SMAD4 CDK2 SMC1A CDKN1A MYC CDKN2D CDKN2B CDKN2C CHEK1 ATR RBX1 SKP2 GADD45B CDC2 HEL2 CCNH SMC3 CDC14B CDC20 CCND3 CDC23 PTTG1 PTTG2 CDC27 SKP1 DKFZp762H177 CCNE2 CDKN1C ANAPC5 ANAPC1 GSK3B CDKN1B MAD1L1 ANAPC2 ANAPC13 PKMYT1 ANAPC10 ANAPC11 CCNB3 CCNB2 CCNB1 ORC3 RAD21 SFN GADD45G ORC2L STAG1 MCM7 ORC1L YWHAQ HEL-S-1 YWHAG ATM YWHAZ SMC1B CCNA2 RBL2 TFDP1 DBF4 TFDP2 ESPL1 MCM5 MCM6 MCM2 TTK FZR1 CDC45 E2F2 E2F3 E2F4 E2F5 ORC6L RBL1 MAD2L2 WEE1 WEE2 DKFZp686I05169 SMAD2 CDKN2A HDAC2 HDAC1 CDK7 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20220510%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells BRAF hCG_16983 APAF1 RELA CASP9 PIK3CA BAK1 MAPK1 SMAD4 CASP3 TRPV5 MTOR FFAR3 TNFRSF1A TNFSF11 MAP3K5 CALCA PPP3R1 SMAD2 SEC16B TGFB1 TGFBR1 HEL-S-41 ACTA2 DKFZp686L23131 MCU PRKCQ RAF1 PTH BAX HEPATITIS B INFECTION%WIKIPATHWAYS_20220510%WP4666%HOMO SAPIENS Hepatitis B infection PIK3R2 PIK3R1 STAT3 EGR2 TNF-alpha PRKCB EP300 PIK3CD IFNA4 IFNA1 IFIH1 TBK1 IF1AA3 IKBKE IF1AA1 JAK1 IF1AA6 IFNA13 IF1AA5 IF1DA1 IF1AA4 IFNA14 STAT1 DDX58 IF1AA9 JAK3 STAT2 IF1AA8 TYK2 TICAM1 MAVS TGFB1 IRF3 STAT4 TRAF3 IF1AB4 TLR3 IFNAR1 IF1AB1 PCNA MAPK3 PTK2B CREB3L3 CREB3L4 DKFZp686N2325 RELA CASP9 NFATC1 NFATC2 SMAD4 STAT6 CREB3 BAD CREB1 CREB5 CYCS CDKN1A TGFBR2 SRC IL6 ATF4 BIRC5 MAPK8 MYC BAX STAT5B MAP2K1 CHUK BRAF FOS MAPK14 NFKB1 hCG_16983 IKBKB TNFSF6 MAPK9 PIK3CA BCL2 MAPK1 IKBKG CASP3 ATF2 DKFZp686M02159 AKT3 MAP3K7 HRAS MAP2K4 TICAM2 MAP2K3 IRAK4 TIRAP JUN TRAF6 IRF7 TLR4 IRAK1 NFATC4 FADD ARAF MAP2K6 MAPK10 MAP3K7IP1 IL8 FAS CASP10 ATF6B MYD88 SOS1 SOS2 PRKCA APAF1 DDB2 NRAS YWHAQ HEL-S-1 YWHAZ MAPK13 MAPK11 KRAS GRB2 MAP3K1 MMP9 SMAD2 TGFBR1 MAP2K2 HSPG2 VDAC3 CREBBP RAF1 NFATC3 DDX3X CASP12 DDB1 PIK3R3 MAPK CASCADE%WIKIPATHWAYS_20220510%WP422%HOMO SAPIENS MAPK cascade SIPA1 MAP3K12 MAP2K1 SOS1 SOS2 RRAS MAP3K2 BRAF MAPK14 MBP MAPK1 NRAS DKFZp686M02159 KRAS GRB2 MAP3K1 HRAS MAP2K4 MAP2K3 JUN PLCB3 MAP2K2 RAF1 MAPK3 ARAF MAP2K6 MAPK10 MAP2 RASA3 LAMTOR3 BUTYRATE-INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20220510%WP2366%HOMO SAPIENS Butyrate-induced histone acetylation ACLY LUNG FIBROSIS%WIKIPATHWAYS_20220510%WP3624%HOMO SAPIENS Lung fibrosis IL12B FAM13A MT2A TIMP1 DSP EDN1 SFTPC ELMOD2 GREM1 RTEL1 SPP1 SFTPA2 DPP9 TNF-alpha STN1 MUC5B PTX3 TERT TGFA HGF CCR3 CCR2 HMOX1 SKIL CCL11 TGFB1 CCL5 CCL4 CCL3 EGF NFE2L2 CTGF FGF5B IL8 SERPINA1 CMA1 IGF1 ATP11A CSF3 CSF2 MMP9 CXCL2 FGF2 IL13 IL1B IL4 KPG_011 IL6 CALCA IL5 CCL2 MMP2 CEBPB PDGFA HIJACK OF UBIQUITINATION BY SARS-COV-2%WIKIPATHWAYS_20220510%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS-CoV-2 CBFB UBA3 TCEB1 NAE1 RBX1 METABOLISM OF TETRAHYDROCANNABINOL (THC)%WIKIPATHWAYS_20220510%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol (THC) CYP2C9 CYP3A4 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20220510%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH SLC52A1 ETFA hCG_2025883 PDSS1 COQ8A COQ7 FLAD1 APTX COQ6 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20220510%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism EPHX2 ALOX5 ALOX15 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20220510%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNB4 CACNA1G CACNA1C CHRNA3 CILIOPATHIES%WIKIPATHWAYS_20220510%WP4803%HOMO SAPIENS Ciliopathies ZNF423 BBS4 DYNC2I2 ODAD1 ODAD3 TRAF3IP1 ODAD4 IFT172 CEP19 CCDC28B MCIDAS TBC1D32 NEK2 CFAP418 DNAAF3 DNAAF2 DNAAF6 DNAJB13 IFT80 RPGRIP1L CFAP410 LZTFL1 FAM161A TMEM138 IFT81 MAK WDPCP CCNQ CCNO CEP104 INTU ARL6 ARL3 AK7 HEL-S-296 ADCY6 DYNC2LI1 PKHD1 INPP5E NPHP1 NPHP3 PIBF1 CEP78 NEK8 BBS2 PLK4 BBS1 DYNC2H1 SMO NEK9 DCDC2 CNGA1 CPLANE1 BBIP1 ZIC2 TMEM231 TMEM17 ARL2BP TMEM237 MKS1 IFT27 UNC119 GLI3 DRC1 DNAL1 INVS C2CD3 CEP164 DNAAF11 FLCN IFT52 AHI-1 TCTN3 SUFU CNGB1 TCTN2 TMEM107 TCTN1 HYDIN BBS9 BBS7 IFT57 BBS5 CC2D2A CEP290 OFD1 IQCB1 OCRL DNAI2 CFAP52 IFT140 KIF7 WDR35 TOPORS RP1 GPR161 BBS10 EVC NME7 BBS12 RP2 TMEM216 NME9 CCDC41 EFHC1 WDR51B ZMYND10 KIZ CFAP53 SDCCAG8 CCDC40 DKFZp564L2416 KATNIP CCDC103 ANKS3 DYNLT2B DNAH6 CRX RSPH9 TULP1 CFAP298 ARL13B RAB23 TMEM67 KIAA0753 PDE6D POC1A RAB28 DNAI1 EVC2 TUB DYX1C1 USP9X hCG_2028821 PCARE SCLT1 RSPH3 RP1L1 RPGRIP1 CENPF RSPH1 TTC8 XPNPEP3 ALMS1 SPAG1 HYLS1 CEP41 B9D2 ATXN10 CLUAP1 TRIM32 PKD1 PIK3R4 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20220510%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway PPARG CYP2C8 EPHX2 CYP4F12 NR1C1 DKFZp686I24235 CYP4A11 CYP4A22 CYP4F2 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20220510%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response RAD51 hCG_16983 hCG_37731 TREX1 CCND1 CHEK1 BBC3 CASP3 ATR CCND2 RAD9A DKFZp686A24188 CDK6 HUS1B TP53AIP1 PIDD1 GADD45B SESN1 CCNE1 TLK2 TLK1 RFC1 CDC2 CDC20B FANCD2 CDK5 PMAIP1 CDK4 PML CCNG1 CCND3 RB1 BRCA1 FAS CCNE2 CHEK2 CDKN1B APAF1 MDM2 CASP9 DDB2 CCNB3 CCNB2 GADD45A CCNB1 PRKDC SFN GADD45G RAD52 MCM7 RAD50 CDK2 MRE11A H2AX CREB1 ATM NBN SMC1A CYCS CDKN1A RAD17 MYC RRM2B BAX NAD METABOLISM IN ONCOGENE-INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION-ASSOCIATED SENESCENCE%WIKIPATHWAYS_20220510%WP5046%HOMO SAPIENS NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence SCO2 PARP1 SIRT5 SIRT1 PRKAA1 NMNAT2 SLC2A4 PBEF1 SIRT2 RELA IL1B SIRT3 IL6 MDH2 HEL-S-32 HMGA1 ELAVL1 RB1 GOT2 CCL27 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20220510%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects MAP2K1 MAPK14 CTNNB1 PIK3CA MAPK1 ATF2 raptor DUOX2 KDM1A FGF8C MC4R RPS6KA6 SLC5A5 AKT3 MLST8 PRKG2 HRAS PPARGC1A FOXO1 POMC ACTL6B ADRB3 RPS6 TSC2 WNT4 SIRT6 PRKCQ FRS2 TSC1 ADCY3 ZNF516 AQP7 AKT1S1 TRH PPARG TTF2 PLIN1 TTF1 SOS1 NHSL1 ITGAV ITPR2 GSK3B KIAA0256 MGLL DUOXA2 AgRP SLC16A2 TSHB DIO1 KDM3B MDM2 SLCO1C1 CASP9 TBC1D4 NPPB PAX8 UCP1 NPPA MAPKAPK3 PFKFB2 ADCY8 NPY DEHAL1 SLC16A10 PRDM16 MAFA TSHR TG CREB3 SLC26A4 BAD MTOR RPS6KB1 RHEB GRB2 FGFR1 PNPLA2 THRA THRB ITGB3 PLCB1 SRC SHH NOTCH1 RAF1 RXRA TPO PROGERIA-ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20220510%WP5103%HOMO SAPIENS Progeria-associated lipodystrophy PPARG PARP1 INS LMNB2 SMAD2 SMAD4 TGFB1 BANF1 C1orf124 KCNJ6 MUCL3 RECQL ZMPSTE24 WRN FNTA LMNA FFAR3 FBN1 PHASE I BIOTRANSFORMATIONS, NON P450%WIKIPATHWAYS_20220510%WP136%HOMO SAPIENS Phase I biotransformations, non P450 PON2 ESD PON1 LIPA CES2 CES1 HEL126 PON3 SYNTHESIS OF CERAMIDES AND 1-DEOXYCERAMIDES%WIKIPATHWAYS_20220510%WP5194%HOMO SAPIENS Synthesis of ceramides and 1-deoxyceramides CERS3 hCG_2045882 B4GALT1 CERS5 CERS6 B4GALNT1 SPHK1 A4GALT MGC26963 A3GALT2 tmp_locus_29 B3GNT5 CERS1 CERS2 SGMS1 CERK DGAT1 UGCG UGT8 SPTLC1 KDSR GPCRS, OTHER%WIKIPATHWAYS_20220510%WP117%HOMO SAPIENS GPCRs, other OR6C2 OR2B6 OR8G1 DRD3 EBI2 DRD4 GPR88 GPR84 MCHR2 NTSR1 GHRHR FY S1PR1 GPR17 HTR1F GPR55 EMR2 EMR3 GPR143 LGR6 OR2A5 ADGRL2 ADGRL3 OR2A4 OR7E24 OR1G1 ADRA1D HTR2A OR7A17 ALG6 CCR5 OR1F1 OR2H1 SSTR2 ADORA2A OR10A5 CCKBR FSHR OR3A3 OR1E1 OR3A1 CNR1 OR2F1 hCG_1644110 CXCR1 CXCR3 P2RY13 P2RY11 SMO CHRM2 CHRM3 GRPR F2R EDNRA OR2M4 DKFZp434B1272 GPR61 HTR7 GPR62 CELSR1 CELSR2 CELSR3 RXFP3 C5AR2 GPR176 GPR132 GRM8 GPR83 GNRHR GPR135 ADRB2 UTS2R ADGRV1 TAAR5 TAAR2 OR1N1 PTGFR GPR162 OR5AC2 ADGRF5 VN1R1 IL8RB OR10A2 OR6C3 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20220510%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP2A13 HEL-S-166mP EPHX1 CYP1A2 GSTM1 CYP3A4 THYROID STIMULATING HORMONE (TSH) SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2032%HOMO SAPIENS Thyroid stimulating hormone (TSH) signaling pathway PIK3R2 PIK3R1 STAT3 MAP2K1 BRAF FOS MAPK14 PIK3CA GNB1 MAPK1 PDE4D GNAI3 MYL12B GNG2 KCNIP3 GNAO1 APEX1 JAK1 RAP1A RPS6KA1 IGF1R HRAS CGA STAT1 MAP2K3 EGR1 JUN RPS6 CCNE1 GNA13 CDK4 MAPK3 CCND3 MAP2K6 ADCY3 RB1 TTF2 TTF1 CDKN1B PDPK1 TSHB SCRIB PAX8 RAP1GAP GNAQ GNAI1 TSHR CDK2 CREB1 MTOR GNAS RBL2 RPS6KB1 PLCB1 SRC RAF1 MYC CEREBRAL ORGANIC ACIDURIAS, INCLUDING DISEASES%WIKIPATHWAYS_20220510%WP4519%HOMO SAPIENS Cerebral organic acidurias, including diseases MDH2 GCDH ADHFE1 D2HGDH L2HGDH ALDH7A1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20220510%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein HSPB11 C11orf60 DYNC2I2 DYNLRB2 DYNC2LI1 RABL5 DYNLT2B DYNC1I1 DYNC2H1 DYNC1H1 IFT140 DYNLL2 IFT80 WDR35 DYNC1LI1 DKFZp686J08252 IFT27 IFT81 hCG_2028821 DNCL1 DYNLT1 DYNLT3 INTERFERON TYPE I SIGNALING PATHWAYS%WIKIPATHWAYS_20220510%WP585%HOMO SAPIENS Interferon type I signaling pathways PIK3R2 PIK3R1 STAT3 PTPN11 MAPK14 CRKL RPS6KA5 raptor PIK3CD RAC1 JAK1 IFNAR2 RAP1A RPS6KA4 MLST8 PRMT1 VAV1 PIAS1 SOCS1 EIF4B STAT1 CRK PTPRC MAP2K3 STAT2 RAPGEF1 TYK2 GAB2 STAT4 RPS6 IRF9 IFNAR1 EIF4A1 LCK ZAP70 MAP2K6 CBL PTPN6 REL MAPKAP1 CREB1 MTOR RPS6KB1 IRS1 MAP3K1 FYN EIF4E SOCS3 EIF4EBP1 FOXP3 IN COVID-19%WIKIPATHWAYS_20220510%WP5063%HOMO SAPIENS FOXP3 in COVID-19 STAT5B STAT3 CD80 IL2 IL2RA IL6R IL2RB IL7R IL6 IL2RG IL6ST FOXP3 HEART DEVELOPMENT%WIKIPATHWAYS_20220510%WP1591%HOMO SAPIENS Heart development FGF5A PTPN11 CTNNB1 NFATC1 MAPK1 NFATC2 SMAD4 SMAD1 BMPR1A MEF2C BMPR2 BMP4 BMP2 HEY1 HEY2 BHLHB2 FOXC2 BMP10 GATA4 FOXC1 ISL1 GATA6 FGF8 DKFZp313O0925 ERBB3 TBX20 NKX2-5 HAND1 PITX2 TBX1 IRX4 SHH FOXH1 NFATC4 NOTCH1 VEGFB VEGFC NFATC3 TBX5 VEGFA TBX2 HAND2 FOXA2 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20220510%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy HSPB8 hCG_1995540 LITAF RAB25 SH3TC2 MFN2 KIF1B RABAC1 RAB4A GDAP1 EGR2 FIG4 RAB7A NEFL RAB11A RAB11B PMP22 MTMR2 HEL-S-102 MPZ RAB3A SBF2 FGD4 RAB3B LRSAM1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION (NBIA) SUBTYPES PATHWAY%WIKIPATHWAYS_20220510%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway ATG10 WIPI1 ATG12 MAP1LC3A FLJ10035 RB1CC1 PRKAA1 PANK2 WDR45 PLA2G6 ACACA DCAF17 STK11 C12orf44 WIPI2 C19orf12 ATG14 CP raptor COASY MTOR FA2H ATG2A ULK1 RHEB MLST8 FTL ATG5 TSC2 TSC1 SPTLC1 PIK3R4 DEPTOR ATG3 AKT1S1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING PATHWAYS%WIKIPATHWAYS_20220510%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling pathways MAP2K1 SOS1 GSK3B CDKN1B NFKB1 CTNNB1 MDM2 CASP9 PIK3CA BCL2 MAPK1 IKBKG CCND1 BAD MTOR KLK3 NFKBIA NFATC2IP PLCL2 KRAS CDKN1A GRB2 AKT3 FOXO1 MAP2K2 CREBBP RAF1 PDGFA CELL DIFFERENTIATION - EXPANDED INDEX%WIKIPATHWAYS_20220510%WP2023%HOMO SAPIENS Cell differentiation - expanded index TLX3 STAT3 ID2 TLX1 MEF2D EZH2 KLF4 RUNX2 PAX7 MEF2C HDAC5 TLX2 MYOD1 LEFTY2 LEFTY1 MEF2B SOX2 EICOSANOID METABOLISM VIA CYCLOOXYGENASES (COX)%WIKIPATHWAYS_20220510%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases (COX) PRXL2B TBXAS1 PTGES NR1C2 PLA2G6 CYP4F2 PTGDR2 AKR1B1 CYP4A11 PTGIR PTGR1 HEL-S-298 HPGD ACOX1 PLA2G5 PLA2G4B EHHADH ACOX2 ACOX3 CYP4A22 PTGDR PTGS2 CYP4F12 PTGDS PTGFR PTGS1 TBXA2R PTGIS LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20220510%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer LRP5 NKD1 NKD2 PORCN WIF1 RYK FOSL1 CDK8 H2AFY2 FZD10 DVL1 WNT10B CTNNB1 TCF3 DVL2 TCF7L1 NOTUM CSNK1A1L WNT16 WNT1 TFAP2A FZD3 WNT3A CCND1 WNT11 FZD1 FZD2 SFRP1 FZD5 CCND2 FZD7 FZD9 FZD8 APC2 MAP3K7 CSNK2A1 JUN CDK6 WNT4 CSNK1A1 CCND3 GSK3B DKFZp586H0919 APC AXIN1 AXIN2 WNT5B WNT3 TCF7L2 WNT10A WNT2B DKK1 LRP6 DKFZp586M1622 WNT7B WNT7A EZH2 FRAT1 CHD8 FRAT2 SOX17 RUVBL1 SOST CER1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E SENP2 DKK4 DKK2 SFRP4 SFRP5 CSNK2B ROR1 CTBP2 ROR2 ATF3 CTBP1 MYC NLK CXXC4 PARKINSON'S DISEASE PATHWAY%WIKIPATHWAYS_20220510%WP2371%HOMO SAPIENS Parkinson's disease pathway CCNE2 HEL-117 UBE1 MAPK14 SLC6A3 APAF1 DDC CASP9 LRRK2 hCG_20684 UBE2L6 UBE2J2 HEL-S-67p PARK2 UBE2J1 UBE2L3 CASP6 CASP3 SNCA UBE2G1 UBE2G2 SNCAIP SEPT5 MAPK13 PINK1 MAPK11 EPRS1 TH SYT11 UBA7 DKFZp686M02159 CYCS ATXN2 HTRA2 GPR37 UBB CCNE1 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20220510%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma KDM6B PIK3CA CHEK1 FGFR4 EP300 ERBIN SETD2 DKFZp451J023 JMJD1C ARID4B HIST1H1E MYBL1 CMTR2 MAGI1 DKFZp762E1511 FBXW7 HRAS HIST1H2AK INSRR ARID5B FOXP2 MORF4L1 NCOR1 KAT6A BCORL1 MYCBP SRCAP UHRF1 DTX4 TLK1 MGA KANSL1 NFIB BCOR ARID1A BRCA1 CHEK2 FOXO3A KMT2C PRKDC SMARCE1 ATM PTEN MAX SMC1A FGF4C MYB MAP2K2 NOTCH1 CREBBP RAF1 CEBPA CTBP1 MYC ERBB2 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20220510%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer PIK3R2 PIK3R1 DLL3 DLL4 DSP FZD10 WNT10B WNT1 WNT16 FZD3 WNT3A WNT11 CLDN4 FZD1 FZD2 ZEB2 FZD5 FZD4 FZD7 FZD9 PIK3CD FZD8 SNAI1 TWIST1 CLDN2 LATS2 FOXC2 TGFB1 PAK1 MAPK3 HIF1A MEF2D WNT5B WNT3 JAG2 SMAD4 WNT10A ID1 WNT2B WNT9B WNT9A WNT8B LRP6 WNT7B ID2 TGFBR2 WNT7A EZH2 COL4A2 COL4A1 MMP2 MAPK8 LRP5 MAP2K1 MAPK14 CTNNB1 PIK3CA MAPK1 DKFZp686M02159 TUSC3 AKT3 HRAS MAP2K4 MAP2K3 TRAF6 WNT4 SPARC DKFZp666F1010 HEL-S-79 CLDN1 FOXQ1 MAP2K6 CDKL2 DKFZp686A1195 CLDN6 CLDN5 SNAI2 CLDN3 CLDN9 COL4A4 SOS1 CLDN7 SOS2 COL4A3 GSK3B PKP2 COL4A6 PKP1 COL4A5 EIF5A2 TWIST2 JUP DKFZp686J1169 SHC1 FOXM1 CLDN22 CLDN20 CLDN24 CLDN23 EED PROX1 CLDN11 CLDN10 CLDN15 MMP15 CLDN14 CTDSP1 CLDN19 MAPK13 CLDN18 MAPK11 CLDN17 RBPJ CLDN16 NR2C2 RBBP4 KRAS GRB2 SUZ12 CDH2 GDF15 NUBPL FMNL2 CRB3 MMP9 VTN SMAD2 TGFBR1 DKFZp434N181 MAP2K2 NOTCH3 NOTCH1 PKD1 RAF1 WNT8A PIK3R3 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20220510%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX3A AP2M1 SLC25A4 STX1A HEL-S-67p CLTCL1 STXBP1 CLTC VAMP2 CLTA AP2A1 RAB3A NAPA SLC22A3 SNAP25 CACNA1B CACNA1A SLC1A3 ATP1A2 CPLX2 CLN8 CPLX1 AP2A2 AP2S1 RIMS1 SLC17A6 SLC17A7 SLC17A8 STX2 SLC18A1 SLC18A2 SLC18A3 UNC13C UNC13B SLC38A1 SLC32A1 UNC13A SYT1 SYP SYN2 DNM3 SYN1 STX1B HYPERTROPHY MODEL%WIKIPATHWAYS_20220510%WP516%HOMO SAPIENS Hypertrophy model MYOG IL1R1 HEL-S-52 IFRD1 ADAM10 GDF8 CYR61 DUSP14 NR4A3 IL1A ANKRD1 HBEGF JUND EIF4E VEGFA IL18 IF2F ATF3 EIF4EBP1 MTHFR DEFICIENCY%WIKIPATHWAYS_20220510%WP4288%HOMO SAPIENS MTHFR deficiency PEMT CASP9 CHPT1 CHKA MARS1 ASMT HEL-S-61p EHMT1 NDUFAF7 CHDH DNMT3B CASP3 SGMS1 GRIN1 ALDH7A1 CYCS ROLES OF CERAMIDES IN THE DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20220510%WP5181%HOMO SAPIENS Roles of ceramides in the development of insulin resistance PIK3R1 PPP2CA IRS1 INS INSR TRAF1 SLC2A4 TNF-alpha ACSL1 ERN1 MAFA PDX1 EIF2AK2 CD36 PRKAG3 RPS6KB1 MAPK8 TNFRSF1A PRKCZ LEUCINE, ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20220510%WP4686%HOMO SAPIENS Leucine, isoleucine and valine metabolism PCCA IVD ACAT1 DBT PCCB MLYCD BCAT1 BCAT2 ACAD8 ECHS1 HIBADH HSD17B10 DLD ACSF3 ACADSB DKFZp434G1411 DKFZp686B20267 ALDH6A1 ACTIVATION OF VITAMIN K-DEPENDENT PROTEINS%WIKIPATHWAYS_20220510%WP5186%HOMO SAPIENS Activation of vitamin K-dependent proteins F7 F2 PROC PROS1 F9 F10 GGCX PROZ NQO1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20220510%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PIK3R2 PIK3R1 PIK3CA PIK3CD PIK3C2A RAC3 RAC1 ITGAM NCF1 NCF2 TREM1 VAV1 PLCG2 ARPC1B NCF4 TREM2 VAV3 FCGR1A FCER1G SYK LYN CYBB ADIB CYBA VAV2 ADIC TYROBP SIGLEC7 LAT ADIA PTPN6 NCKAP1L PIK3R3 SUPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20220510%WP4479%HOMO SAPIENS Supression of HMGB1 mediated inflammation by THBD CHUK HMGB1 NFKB1 IKBKB NFKBIA RELA THBD IKBKG PATHOGENESIS OF SARS-COV-2 MEDIATED BY NSP9-NSP10 COMPLEX%WIKIPATHWAYS_20220510%WP4884%HOMO SAPIENS Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex IL8 CD247 CRP LBP IL6 HLA-DRA FYN HLA-DRB1 HLA-DRB5 LCK NRF CD8B1 CD3G ZAP70 PRG3 CD8A CD3E CD2 MMP25 IGLL1 TNF-ALPHA SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP231%HOMO SAPIENS TNF-alpha signaling pathway CHUK NFKB1 hCG_16983 IKBKB MAPK9 TNF-alpha MAPK1 IKBKG CDC37 CASP3 TBK1 TRAF2 TXN TNFRSF1A PRKCZ RAC1 MAP3K8 MAP3K7 HRAS MAP2K4 CSNK2A1 MAP3K5 MAP2K3 JUN CYBA NFKB2 RIPK1 FADD MAPK3 MAP2K6 KSR1 MAP3K7IP1 SKP1 OTUD7B PPP2CA TAB3 PYGL SOS1 TNFAIP3 SMPD2 NFKBIB PIG59 MAP4K2 RIPK3 PLK1 TRAF1 KSR2 TNFRSF1B SELE APAF1 MADD PTPRCAP CASP9 NSMAF TANK RFFL DKFZp781N011 REL NFKBIE NRAS BAD NFKBIA TRADD DIABLO KRAS GRB2 MAP3K1 BIRC2 BIRC3 IL6 PSMD2 BCL2L1 CCL2 CREBBP RAF1 DKFZp686J04131 MAPK8 BAX BREAST CANCER PATHWAY%WIKIPATHWAYS_20220510%WP4262%HOMO SAPIENS Breast cancer pathway PIK3R2 PIK3R1 DLL3 DLL4 FZD10 DVL1 FGF23 WNT10B DVL2 TCF7L1 FGF22 WNT1 WNT16 HES5 FZD3 WNT3A CCND1 WNT11 FZD1 FZD2 FZD5 FZD7 FZD9 PIK3CD FZD8 APC2 TNFSF11 FGF7B IGF1R FGF7A CDK6 FGF6B FGF6A NFKB2 CSNK1A1 CDK4 SP1 MAPK3 EGF RB1 FGF5C BRCA1 FGF5B FGF5A APC WNT5B IGF1 GADD45A PGR WNT3 JAG2 ESR2 CETN3 WNT10A HEYL POLK WNT2B HEY1 LRP6 CDKN1A WNT7B WNT7A FRAT2 CSNK2A3 CSNK2A2 HES1 SFRP4 CSNK2B MYC ERBB2 BAX LRP5 MAP2K1 BRAF FOS RAD51 CTNNB1 CSNK1A1L PIK3CA MAPK1 ATR FGF8C KIT PARP1 AKT3 HRAS CSNK2A1 JUN SHC4 SHC2 SHC3 GADD45B WNT4 ARAF SKP1 SOS1 SOS2 GSK3B DKFZp586H0919 AXIN1 AXIN2 FGF8A DDB2 SHC1 BAK1 TCF7L2 GADD45G NCOA1 NRAS RAD50 MRE11A ATM MTOR NBN BRCA2 RPS6KB1 PTEN DKFZp586M1622 RPS6KB2 KRAS GRB2 FGFR1 HEY2 FGF4B FRAT1 E2F2 FGF4A E2F3 FGF2 FGF4C FLT4 FGF8 DKFZp434N181 MAP2K2 EGFR NOTCH3 NOTCH1 RAF1 PIK3R3 GLUCURONIDATION%WIKIPATHWAYS_20220510%WP698%HOMO SAPIENS Glucuronidation UGT2B28 UGT2A3 UGT2A2 UGT2A1 UGT1A5 UGT2B4 UGT2B7 UGT1A10 UGT2B10 UGDH UGT1A4 PGM3 PGM2 UGT1A1 PGM5 UGT1A3 UGT1A9 UGT1A8 UGT2B11 UGT2B15 UGT1A7 UGT2B17 METABOLISM OF SPINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20220510%WP4142%HOMO SAPIENS Metabolism of spingolipids in ER and Golgi apparatus CERS3 B4GALT1 SPHK2 B4GALNT1 SPHK1 MGC26963 SGPP2 SGPP1 CERK B4GALT2 UGCG GALNT16 UGT8 GALNT1 SGPL1 OK/KNS-cl.1 B3GALT2 B3GALT1 KDSR ST6GALNAC3 OXYTOCIN SIGNALING%WIKIPATHWAYS_20220510%WP2889%HOMO SAPIENS Oxytocin signaling OXTR GNAQ CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20220510%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPL23 RPS5 RPL22 RPL13A RPSA RPS3A RPL37A RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL19 RPS6KA3 RPL41 RPS6KA6 RPL35A RPL23A RPS6KA2 RPL3L RPS26 RPS6KA1 RPS25 RPS28 RPS27 RPL11 RPS29 hCG_24487 RPL27A RPS20 RPS21 RPS24 RPS23 RPS6 RPS6KB1 RPS6KB2 HEL-S-310 RPL4 RPL5 RPL30 RPL3 RPL32 hCG_1994130 RPL31 RPL34 RPLP1 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 HEL112 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20220510%WP322%HOMO SAPIENS Osteoblast signaling TNFSF11 ITGAV PDGFRA BGLAP FGF23 ITGB3 PTH1R COL1A1 PTH TNFRSF11B IBSP SLC17A2 PRE-IMPLANTATION EMBRYO%WIKIPATHWAYS_20220510%WP3527%HOMO SAPIENS Pre-implantation embryo GATA3 GATA2 H2AFY2 FOSB TCF7L1 KLF4 TFAP2B IRF4 DDIT3 CDX2 MYBL1 TEAD4 EGR1 SOX8 NANOGNB AQP9 NR3C2 ZFP36 DNMT3L KHSRP SIX3 BATF3 FOXD1 SOX11 ZAR1 FOXQ1 ARGFX DPPA3 HMGA1 ELAVL1 ZFP42 DLX2 PADI6 ATP1A1 AQP3 BARX2 ZFP36L2 LEUTX MOS NLRP5 NKX2-1 MTA3 ESRRA IRX5 TPRX1 HNRNPAB TBX3 PBX1 DPRX ZSCAN4 SMARCA4 MXD1 SOX2 POU5F1 E2F5 EXERCISE-INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20220510%WP410%HOMO SAPIENS Exercise-induced circadian regulation HIST1H2BN DAZAP2 HLA-DMA BTG1 TOB1 PURA SUMO1 UCP3 STBD1 SUMO3 G0S2 QK3 ERC2 hCG_2043421 CBX3 HEL-S-72p ZFR NR1D2 HEL-S-22 ETV6 PER2 PER1 PPP1R3C AAG1 NCKAP1 VAPA CRY2 KLF9 IDI1 CRY1 MYF6 PIGF GSTM3 CEBPB PSMA4 CLDN5 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20220510%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway MAP2K1 BRAF ARHA FOS MAPK14 PDPK1 HTR1E HTR1F HTR1D HTR1B PIK3CA MAPKAPK3 MAPK1 RPS6KA5 GNAI1 GNAI3 5HT1A GNAO1 CREB1 MAPKAPK2 RAP1A MAP3K1 MAP2K3 MAP2K2 RASGRF1 MAPK3 MAP2K6 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20220510%WP3945%HOMO SAPIENS TYROBP causal network in microglia HCLS1 SFT2D2 TMEM106A GPX1 RBM47 IGSF6 KCNE3 SAMSN1 ADAP2 HLX CYTL1 SH2B3 SPP1 IL10RA LHFPL2 HIMAP2 PYCARD IL18 RPS6KA1 NCF2 TYROBP ITGAX ZFP36L2 TNFRSF1B DKFZp686N2325 MAF DPYD ITGAM GAL3ST4 CD84 NRROS FKBP15 LYL1 PLEK LOXL3 TCIRG1 CXCL16 RGS1 TGFBR1 FLJ33641 CD37 ADIB hCG_1821276 IL13RA1 RNASE6 HEL-S-66 RUNX3 LGALS9C HEL-S-62p LGALS9B APBB1IP SLC7A7 BIN2 NPC2 NCKAP1L ELF4 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20220510%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20220510%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias DHCR7 LBR SC5DL CYP51A1 DHCR24 EBP NON-CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20220510%WP5133%HOMO SAPIENS Non-classical role of vitamin D CYP27B1 CYP2R1 AGTR1 AGTR2 REN ACE2 KININ-KALLIKREIN PATHWAY%WIKIPATHWAYS_20220510%WP5089%HOMO SAPIENS Kinin-Kallikrein pathway CPN1 SERPING1 BDKRB2 BDKRB1 KLKB1 KNG1 LAMIN A-PROCESSING PATHWAY%WIKIPATHWAYS_20220510%WP4299%HOMO SAPIENS Lamin A-processing pathway ZMPSTE24 LMNA COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20220510%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20220510%WP661%HOMO SAPIENS Glucose homeostasis INS RESOLVIN E1 AND RESOLVIN D1 SIGNALING PATHWAYS PROMOTING INFLAMMATION RESOLUTION%WIKIPATHWAYS_20220510%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution CMKLR1 FPRL1 PIK3CD MTOR PIK3CA LTB4R EPHB2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20220510%WP2406%HOMO SAPIENS Cardiac progenitor differentiation INS MAPK14 MESP2 WNT3A MESP1 MYLK3 SOX1 SCN5A MEF2C NOG PAX6 BMP4 MYL2 MYH6 THY1 TBXT KIT TNNI3 IGF2 INHBA LIN28B LIN28A NODAL MIXL1 SIRPA GATA4 TBX20 TGFB1 NKX2-5 IRX4 TBX5 ZFP42 FOXA2 KDR CXCR4 NCAM1 GSK3B IGF1 DKK1 NRG1 SOX2 POU5F1 FGF2 SOX17 ISL1 PDGFRA NOTCH1 BMP1 ROR2 COVID-19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20220510%WP4891%HOMO SAPIENS COVID-19 adverse outcome pathway IL8 CSF3 IL10 IL1B TNF-alpha IL6 ACE2 IL7 IL2 CCL2 CCL3 IL2RA CXCL10 TMPRSS2 MED AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20220510%WP4789%HOMO SAPIENS MED and pseudoachondroplasia genes COMP MATN1 COL9A1 COL9A2 MATN3 COL9A3 STING PATHWAY IN KAWASAKI-LIKE DISEASE AND COVID-19%WIKIPATHWAYS_20220510%WP4961%HOMO SAPIENS STING pathway in Kawasaki-like disease and COVID-19 CHUK IF1DA1 GSDMD NFKB1 CGAS F3 IKBKB RELA FCGR2A IL1B FCGR2C REL IKBKG NFKBIE IRF3 NLRX1 NLRP3 MITA NFKBIA TBK1 IKBKE HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20220510%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma PIK3R2 PIK3R1 PIK3R5 NFKB1 CTNNB1 hCG_16983 PIK3CA CCND1 FGFR3 FGFR2 raptor TERT AKT3 MLST8 IGF1R HRAS MAML1 SESN2 TP63 CDK6 NUMB IRF6 AJUBA SESN1 RPS6 TRAF3 CSMD3 FAT1 TSC2 NFKB2 TSC1 CDK4 FADD VEGFA RB1 NFE2L2 RICTOR PDPK1 PRKAA1 RELA PRKAA2 REL STK11 NRAS SMAD4 MAPKAP1 FKBP1A MTOR DDIT4 PTEN RHEB RPS6KB2 KRAS CDKN1A TGFBR2 FGFR1 BIRC2 EIF4E DKFZp434N181 CDKN2A EGFR NOTCH1 KEAP1 ERBB2 EIF4EBP1 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20220510%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GATF-C GLYATL2 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20220510%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine PTS FACTORS AND PATHWAYS AFFECTING INSULIN-LIKE GROWTH FACTOR (IGF1)-AKT SIGNALING%WIKIPATHWAYS_20220510%WP3850%HOMO SAPIENS Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling RICTOR GSK3B MAP1LC3A NFKB1 GDF8 IGF1 HEL-S-28 MAPKAP1 raptor MTOR WASL RPS6KB1 PTEN TNFRSF1A IRS1 MLST8 IGF1R PPARGC1A IGFBP5 SMAD2 EIF4E ITGB1 TRIM63 EIF2B2 TNLG5A FBXO32 ACVR2B JKAMP PRKAB1 DEPTOR AKT1S1 REGULATION OF APOPTOSIS BY PARATHYROID HORMONE-RELATED PROTEIN%WIKIPATHWAYS_20220510%WP3872%HOMO SAPIENS Regulation of apoptosis by parathyroid hormone-related protein BCL2L2 BOK PTHLH GSK3B BCL2 BAK1 GSK3A MCL1 BCL2L1 ITGA6 BCL2A1 ITGB4 BCL2L12 hCG_27697 BCL2L10 MYC BAX DKFZp451F173 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE-ANAPHASE TRANSITION%WIKIPATHWAYS_20220510%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase-anaphase transition BUB1B CENPE MAD2L1 MAD1L1 ANAPC2 ANAPC11 RAD21 STAG1 SMC3 CDC20 PTTG1 SMC1A ESPL1 FELBAMATE METABOLISM%WIKIPATHWAYS_20220510%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20220510%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy CACNA1C CTNNA1 DSP CTNNB1 TCF7L1 EMD ITGA6 ACTG1 SLC8A1 PS1TP5BP1 ITGA1 CXNK2 ITGB4 DAG1 ITGAV DKFZp586H0919 ATP2A2 PKP2 SGCD SGCB ITGB8 ITGB7 SGCG ITGA4 JUP RYR2 ITGA2 CTNNA3 CACNA2D1 CACNA2D3 CTNNA2 CACNA2D2 TCF7L2 CACNA2D4 ACTN4 CACNB1 CACNB3 CACNB4 ITGA7 DSG2 DSC2 CACNA1D CACNA1F CACNG6 CACNG7 CACNG8 LMNA DMD CACNA1S CACNG1 CACNG2 CDH2 CACNG3 ITGB5 CACNG4 CACNG5 tmp_locus_29 ITGB3 ITGA2B ITGB6 ITGB1 ACTN1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20220510%WP45%HOMO SAPIENS G1 to S cell cycle control CDKN2D CDKN2B CDKN2C CCND1 CCND2 CDK6 CCNE1 CDC2 CCNH CDK4 PCNA CCND3 RB1 ATF6B CDKN1C CCNE2 CDKN1B CREB3L3 CREB3L4 MDM2 GADD45A CCNB1 ORC3 ORC2L MCM7 ORC1L CREB3 CDK2 RPA1 CREB1 ATM TFDP1 TFDP2 CDKN1A MCM5 MCM6 MCM2 POLE MYT1 CDC45 PRIM1 E2F2 E2F3 PRIM2A POLA2 CCNG2 ORC6L RPA3 POLE2 WEE1 MNAT1 CDKN2A MYC CDK7 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway PTGES3 S100P SPRY1 NR1i2 TNS4 KTN1 NR3C1 RGS2 SCNN1A SLC26A2 ABHD2 BHLHB2 SLC19A2 JUN GADD45B PLK2 DNAJC15 NFKB2 SPINK13 DKFZp686C06176 SNAI2 CPEB4 CDKN1C TNFAIP3 ACKR3 EPB41L4B DNER THBD ENC1 ARL5B ANKRD1 ZIC2 IL11 PDE4B FGFBP1 SRGN EDN2 TSC22D3 SERPINB9 TGFBR3 NAV3 POU5F1 ADGRF4 B3GNT5 BIRC2 CDC42EP3 BIRC3 PMP2 MGAM ANGPTL4 NR1I3 AMIGO2 PRRG4 PTGS2 STOM CCL2 FGD4 GPR153 RXRA SERTAD2 PPP1R14C CAVIN2 ALOX5AP CCL20 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20220510%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2B6 UGT1A9 CYP2A6 AOX1 DYRK1A%WIKIPATHWAYS_20220510%WP5180%HOMO SAPIENS DYRK1A HES5 CCND1 CASP3 raptor MLST8 SIRT1 LATS2 FOXO1 CDK6 TSC2 APP CSNK1A1 DYRK1A TSC1 CDK4 DEPTOR AKT1S1 GSK3B CDKN1B SPRY2 CASP9 DNER NFATC1 CREB1 MTOR RBL2 TFDP1 TFDP2 RBBP4 CRY2 E2F4 FGF2 E2F5 RBL1 GMNN DCAF7 KIAA1149 DKFZp686L18142 LIN52 PSENEN TFDP3 AMPH HES1 NOTCH1 LIN37 LIN9 PSEN1 EIF2B5 H3F3A REST TFAP4 NEUROG2 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20220510%WP5173%HOMO SAPIENS Disorders of galactose metabolism GYS1 HEL-S-19 PYGL GYG1 SLC2A2 AKR1B1 SLC5A1 GYS2 DOCOSAHEXAENOIC ACID (DHA) OXYLIPIN METABOLISM%WIKIPATHWAYS_20220510%WP5154%HOMO SAPIENS Docosahexaenoic acid (DHA) oxylipin metabolism PTGS2 EPHX2 SPINAL CORD INJURY%WIKIPATHWAYS_20220510%WP2431%HOMO SAPIENS Spinal cord injury IL1R1 MBP TNF-alpha CCND1 GFAP APEX1 LTB4R RAC1 CXNK2 FCGR2A FCGR2C ROCK2 TGFB1 CDC42 IL2 CDK4 MAPK3 NTN1 RB1 AQP4 ARHA RGMA GADD45A PLA2G6 CDK2 NOS2 FKBP1A GRIN1 PLA2G5 CXCL1 CXCL2 IL4 COL4A1 IL1A IL6 CCL2 LTB IF2F MYC hCG_2043376 HEL113 XYLT1 FOS AQP1 ROS1 SEMA6A OMG MIF PDYN hCG_22119 BCAN RTN4R MAPK1 KLK8 RTN4 EFNB2 PLXNA2 TNFSF13 SELP GDNF CASP3 PTPRA CSPG4 CSPG3 BTG2 PRB1 ANXA1 ARG1 TACR1 MMP12 VCAN GAP43 CD47 AIF1 ACAN SLIT1 TNLG7A CCR2 SLIT3 SLIT2 LILRB2 LILRB3 EGR1 SOX9 ZFP36 TLR4 NGFR CDC2 CCNG1 CXCL10 LEP IL8 EPHA4 PRKCA CHST11 CDKN1B FOXO3A BDNF PPP3CA MMP9 E2F5 IL1B RHOB COL2A1 PTGS2 EGFR ADIA PLA2G2A PI3K-AKT SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4172%HOMO SAPIENS PI3K-Akt signaling pathway PIK3R2 PIK3R1 XB PIK3R5 KITLG FGF23 FGF22 GNG12 FGF1B FGF1A FGFR4 FGFR3 GNG2 FGFR2 CCND2 PIK3CD IGF2 RAC1 ITGA1 COMP FGF7B COL9A2 FGF7A EIF4B IL2RB FGF6B CDK6 FGF6A VEGFB VEGFC IL2RA VEGFA MAPK3 IL7R EGF DKFZp666O0110 FGF5C BRCA1 FGF5B FGF5A ITGB8 MDM2 ITGB7 IGF1 RELA CASP9 ITGA4 ITGA2 STK11 ITGA7 BAD BCL2L11 ITGB5 CSF3 IRS1 LAMB2 CSF1 LAMA4 LAMC1 THBS2 THBS1 IL6R COL1A2 COL4A2 IL4 COL4A1 IL3 IL6 COL6A1 IL7 ITGB6 MCL1 BCL2L1 ITGB1 ATF4 MYC GYS2 EIF4EBP1 GYS1 ANGPT4 ANGPT2 ANGPT1 INSR TNFSF6 CDC37 EPHA2 TGFA PCK1 PPP2R2A HEL-S-125m TCL1B TCL1A FLT3LG LPAR3 DKFZp781N0293 CD19 PDGFD PDGFC PCK2 GNG11 GNG13 PRL GNGT2 hCG_1994888 OSMR SGK3 CCND3 SGK1 SGK2 PHLPP2 PHLPP1 PKN3 NTF5 ATF6B RELN CCNE2 COL4A4 OSM PRKCA CDKN1B VEGFD COL4A3 CSHL1 GHB2 COL4A6 GHB3 PKN2 COL4A5 PKN1 CSF3R FGF8A TNC TNR PRLR EIF4E1B CSH2 EFNA4 CHAD FLJ00308 BDNF G6PC1 EFNA1 GH1 EFNA3 G6PC2 EFNA2 G6PC3 GNB2 GNB4 RBL2 GNB3 GNB5 PTEN FLT3 EDG2 LAMC2 EDG4 GHR PPP2R5E VWF PPP2R5B PPP2R5A PPP2R5C IL3RA COL6A6 COL6A5 LAMA5 LAMA1 LAMA3 THBS4 THBS3 GNG3 COL2A1 GNG5 GNG4 PPP2R3C EIF4E GNG7 NTRK2 GNG8 EGFR LAMB3 LAMB4 LAMB1 PPP2R3B PPP2R3A EPOR PPP2R2C PPP2R2B PPP2R2D INS CCND1 IFNA4 IFNA1 ITGA6 IF1AA3 IF1AA1 HGF JAK1 IFNAR2 IF1AA6 IFNA13 IF1AA5 IF1DA1 IF1AA4 IGF1R IFNA14 IF1AA9 JAK3 IF1AA8 SYK CCNE1 IF1AB4 IL2 IFNAR1 PPP2R1A IF1AB1 CDK4 ITGB4 EFNA5 FGF13 PPP2R5D HSP90AB1 PPP2R1B KDR CREB3L3 CREB3L4 COL1A1 DKFZp686N2325 IL2RG CDK2 CREB3 CREB1 DDIT4 CREB5 CDKN1A KPG_010 COL9A1 COL9A3 LPAR4 MAP2K1 CHUK NFKB1 GNGT1 IKBKB SPP1 PIK3CA GNB1 BCL2 MAPK1 IKBKG ATF2 raptor CSF1R FLT1 FGF8C KIT AKT3 MLST8 HRAS IBSP RPS6 TLR4 NGFR TSC2 TSC1 NGF PPP2CA NTF3 SOS1 ITGAV SOS2 GSK3B FOXO3A NTRK1 PDPK1 PRKAA1 PRKAA2 NRAS CHRM2 CHRM1 MTOR RPS6KB1 RHEB RPS6KB2 KRAS GRB2 FGFR1 F2R FGF4B FGF4A EPO VTN FGF2 ITGB3 ITGA2B FLT4 FGF8 MYB PDGFRA MAP2K2 RAF1 PDGFA PIK3R3 DOWNREGULATION OF ACE2 BY SARS-COV-2 SPIKE PROTEIN%WIKIPATHWAYS_20220510%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS-CoV-2 spike protein AGTR1 AGTR2 ACE2 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20220510%WP453%HOMO SAPIENS Inflammatory response pathway TNFRSF1B COL1A1 IL2RG TNFRSF1A LAMC2 CD40 LAMB2 CD80 LAMC1 THBS1 VTN COL3A1 LAMA5 COL1A2 IL2RB IL4 THBS3 IL5 IL2 LAMB1 LCK IL2RA ZAP70 IF2F CD40LG IL5RA CONGENITAL GENERALIZED LIPODYSTROPHY (CGL)%WIKIPATHWAYS_20220510%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy (CGL) BSCL2 GRB2 HMFN0839 LPIN3 IRS1 INS PIK3CA LPIN1 LPIN2 FYN DGAT2 DGAT1 ITGB4 AGPAT2 HIF1A CAVIN1 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20220510%WP4725%HOMO SAPIENS Sphingolipid metabolism overview CERS3 hCG_2045882 CERS6 SPHK2 SPHK1 MGC26963 SGPP2 SGPP1 DEGS1 DEGS2 PLPP3 CERS1 CERS2 SGMS1 CERK UGCG UGT8 SGPL1 SPTLC1 SPTLC2 SMPD1 KDSR MAPK AND NFKB SIGNALING PATHWAYS INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20220510%WP3849%HOMO SAPIENS MAPK and NFkB signaling pathways inhibited by Yersinia YopJ CHUK MAP3K1 RRAS NFKB1 IKBKB RAF1 NFKBIA MAP2K6 DKFZp686J04131 TRAF6 MAPK1 IKBKG BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20220510%WP272%HOMO SAPIENS Blood clotting cascade F8A3 F7 SERPINF2 VWF F11 F2 F5 F8 KLNA1 F9 F13B F10 PLG F3 HEL-S-78p KLKB1 SERPINB2 SERPINE1 PLAT FGA NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20220510%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons DRD3 DRD4 CHRNB2 CHRNA5 DDC KCNK9 CHRNA6 GNB1 PPP1R1B KCNK3 GNAI1 GNG2 SLC18A2 CDK5 TH CHRNA3 DRD2 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20220510%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling RORA GATA3 STAT3 IL12A NFKB1 NOD2 NFATC1 TNF-alpha IL2RG IF2B1 FOXP3 IL23R HLA-DMA RORC MAF IL-21 STAT6 IL18RAP TBX21 IL21R IL23A IL17F IL18 IL10 STAT1 IL13 IL4 JUN IL1A IL6 IL5 SMAD2 STAT4 TGFB1 TLR5 TLR4 IL2 IFNGR1 IF2F IL12RB1 CCL18 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP5097%HOMO SAPIENS CCL18 signaling pathway PTK2B HEL113 VCAM1 HEL-S-133P TFAP2A NEFL HEL-S-61 TMEM49 ZEB2 FZD4 EP300 AK4 MTERF4 CD44 SNAI1 PTEN TWIST1 CCR8 CDH2 CSF2 COX2 MMP9 TEAD4 STAT1 MTDH COL1A2 ACTA2 MMP2 VEGFC ATF3 HIF1A MYC IMMUNE RESPONSE TO TUBERCULOSIS%WIKIPATHWAYS_20220510%WP4197%HOMO SAPIENS Immune response to tuberculosis IFIT3 JAK1 IFNAR2 MED14 OAS1 IRF1 PIAS1 SOCS1 STAT1 STAT2 TYK2 IRF9 IFNAR1 PSM8 IFNGR1 IFITM1 IFNGR2 MX1 TAP1 IFI35 IFIT1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20220510%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure HEL-S-2a PARP2 CASP3 CYP11A1 HSD3B2 STAR MAPK10 BAX 7-OXO-C AND 7-BETA-HC PATHWAYS%WIKIPATHWAYS_20220510%WP5064%HOMO SAPIENS 7-oxo-C and 7-beta-HC pathways EPHX2 BAAT SLC27A5 DBP THEM5 ACOT9 ACOX2 ACOT8 ACOT7 HSD11B1 ACOT11 HSD11B2 ACOT12 ACOT13 AMACR EBP NPC1 ACOT2 ACOT6 SLC27A2 DHCR7 ACOT4 CYP7A1 CYP27A1 NPC2 TGF-BETA SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP366%HOMO SAPIENS TGF-beta signaling pathway PIK3R2 PIK3R1 FOSB CCND1 ZEB2 MEF2C EP300 HGS TERT RAC1 PIAS1 SKI SIN3A ROCK1 SKIL MAP4K1 TGFB1 CDC42 ZFYVE9 SNIP1 RNF111 FOXH1 NUP214 PIAS2 EID2 SP1 MAPK4 ZFYVE16 SIK1 SPTBN1 ITGB4 UBE2I SMURF2 DKFZp666O0110 SMURF1 NUP153 SNW1 COPS5 DCP1A CITED1 ARHA TGFB1I1 LIMK2 KLF10 ITCH TGIF1 UCHL5 PJA1 NEDD9 STAMBPL1 RUNX2 ITGA2 WWP1 KLF6 DKFZp781N011 TIEG2 FOXP3 SMAD4 CDKN1A TGFBR2 TGFBR3 THBS1 COL1A2 SRC ITGB1 DKFZp451O0517 ATF3 MAPK8 MYC MAP2K1 JUNB FOS MAPK14 MAPK9 MAPK1 CDKN2B ATF2 RBX1 MMP12 MAP3K7 MAP2K4 MAP2K3 JUN TRAF6 JUND CDC2 APP PML MAP2K6 MAP3K7IP1 SKP1 SOS1 AXIN1 TNC CCNB2 SHC1 SUMO1 RBL2 TFDP1 GRB2 E2F4 ITGB3 E2F5 PARD6A RBL1 SMAD2 TGFBR1 MAP2K2 CREBBP RAF1 HDAC1 FOCAL ADHESION%WIKIPATHWAYS_20220510%WP306%HOMO SAPIENS Focal adhesion PIK3R2 PIK3R1 XB PIP5K1C CRKL CCND1 MYLK3 MYL12B PRKCB CCND2 MYL2 PIK3CD ITGA6 HGF RAC3 RAC1 RAP1A ITGA1 COMP IGF1R VAV1 CAV2 TNK2 PTK6 CRK DOCK1 ROCK1 RAPGEF1 ROCK2 VAV3 CDC42 VAV2 PAK1 PAK6 VEGFB VEGFC MAPK3 VEGFA PAK4 ITGB4 EGF DKFZp666O0110 KDR ARHA ITGB8 ITGB7 IGF1 COL1A1 ITGA4 ITGA2 MYLK2 MYLK4 PPP1CC ACTN4 HEL-S-80p MYL5 MYL7 TLN2 ITGA7 TLN1 BAD BLK TXK MYL12A MYL10 VASP SRMS CAV3 TNK1 PARVA PARVB MYLPF PARVG ITGB5 ARHGAP5 LAMB2 PPP1R12B PPP1R12C LAMA4 LAMC1 FLNA THBS2 FLNB THBS1 STYK1 c-fgr COL1A2 BIRC2 ZYX COL4A2 BIRC3 COL4A1 SRC COL5A3 COL5A2 ITGB6 ITGB1 MAPK8 ERBB2 MAP2K1 BRAF CTNNB1 MAPK9 PIK3CA SPP1 BCL2 MAPK1 FLT1 ACTG1 PS1TP5BP1 AKT3 HRAS JUN IBSP SHC4 SHC2 SHC3 PDGFD PDGFC RASGRF1 CCND3 MAPK10 COL4A4 SOS1 RELN ITGAV PRKCA GSK3B VEGFD COL4A6 PDPK1 HEL-S-28 TNC TNR SHC1 CHAD PTEN GRB2 LAMC2 VWF HEL114 VTN ITGB3 ITGA2B ARHGAP35 LAMA5 LAMA1 MYLK LAMA3 THBS4 THBS3 COL2A1 FYN PDGFRA EGFR LAMB3 ACTN1 LAMB1 RAF1 PXN PDGFA PIK3R3 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20220510%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation PIK3R2 PIK3R1 CHUK ARHH NFKB1 IKBKB SH2B3 IKBKG MAP3K8 VAV1 SOCS1 MAP4K1 TRAF6 GNA13 ITK PRKCQ LAT LCK CD3G ZAP70 CD8A CD3E PTPN6 CD247 TNFAIP3 MEF2D CDKN1B PDPK1 RELA REL DKFZp434N101 NFKBIA GRB2 FLJ00120 DGKA CD3D TMEM222 GRAP2 ARIH2 UBASH3A DGKZ RASA2 LCP2 CUL5 NDUFB10 BCL10 RNF7 RPRD1B SH2D1A FIBP CD5 DKFZp686J04131 AGO1 CANONICAL AND NON-CANONICAL TGF-B SIGNALING%WIKIPATHWAYS_20220510%WP3874%HOMO SAPIENS Canonical and non-canonical TGF-B signaling TGFBR2 MAPK14 GREM1 MAPK9 SMAD2 SMAD4 TGFB1 TGFBR1 BMPR1A LOXL4 BMPR2 BMP1 LOXL1 MAPK8 LOXL2 LOX SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20220510%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD NKX2-5 MEF2D MEF2C CAMK2D CCND2 KLF4 MEF2B APOPTOSIS-RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20220510%WP2864%HOMO SAPIENS Apoptosis-related network due to altered Notch3 in ovarian cancer BEX3 PTK2B DKFZp686P17171 HEL-S-89n CDKN1B HEL113 HSPD1 CTNNA1 HELLS NET1 TRAF1 NFKB1 CARD14 AXIN1 TNFRSF21 PKN1 APOE TNF-alpha MAPK1 RIPK2 RPS6KB1 NRG1 CSDA CDKN1A HEL-S-102 SQSTM1 F2R THBS1 DKFZp686A24188 VAV3 ERBB3 JUND ERN1 CUL5 APP RNF7 GCLC HEL-S-7 BIRC5 IL7R HDAC1 NQO1 SOCS3 DKFZp666O0110 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20220510%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development CTNNB1 DMP1 DSPP SP7 KLF4 RUNX2 HNF1A SOST DKFZp434N181 DKK1 NOTCH3 NOTCH1 ALPL CELL MIGRATION AND INVASION THROUGH P75NTR%WIKIPATHWAYS_20220510%WP4561%HOMO SAPIENS Cell migration and invasion through p75NTR STAT3 ARHA KIDINS220 ARF1 TRIO EFNB1 PARD3 ADAMTS13 EFNA4 EFNB3 EFNB2 CDH11 BDNF EFNA1 EFNA3 EFNA2 TWIST1 RAC1 AKT3 MMP9 TIAM1 JUN PAK1 NTRK2 NGFR MMP2 EFNA5 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20220510%WP4595%HOMO SAPIENS Urea cycle and associated pathways GLUD1 ASL GPT OTC HEL-S-281 ALDH4A1 FH SLC25A15 NOS2 MDH2 NAGS SLC25A12 SLC25A13 HEL-S-32 GLS2 ASS ARG1 GOT2 INSULIN SIGNALING IN ADIPOCYTES (NORMAL CONDITION)%WIKIPATHWAYS_20220510%WP3634%HOMO SAPIENS Insulin signaling in adipocytes (normal condition) RPS6 IRS1 INSR SLC2A4 MTOR TBC1D4 RPS6KB1 ERK PATHWAY IN HUNTINGTON'S DISEASE%WIKIPATHWAYS_20220510%WP3853%HOMO SAPIENS ERK pathway in Huntington's disease RPS6KA5 NTRK2 BDNF CASP3 EGFR CREB1 HTT HRAS RAF1 EGF MAPK1 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20220510%WP2857%HOMO SAPIENS Mesodermal commitment pathway GATA3 TCF7L1 KLF4 KLF5 WNT3A CCND1 ZIC5 DNMT3B TBX6 FZD5 FZD4 NOG BMP4 PAX6 FZD8 SNAI1 TCF4 INHBA NODAL MIXL1 PIAS1 BHLHB2 LATS1 FOXC2 FOXC1 GATA6 TEAD2 VAV3 PITX2 TBX1 FOXH1 ACVR2B FOXA2 NFE2L2 ACACA WNT3 ZIC2 SMAD4 SMAD1 BMPR1A DKK1 BMPR2 CCDC6 LEFTY2 LEFTY1 SOX2 SOX17 PLCH1 DKFZp451O0517 RPL38 NLK HTT FOXA1 SOX21 NR2A1 TRIM28 CEP250 ACVR1 SETD2 DKFZp451J023 HES7 WDHD1 EMSY ADAM19 TWSG1 HPRT1 CRTC1 WDFY2 TOX MACF1 MBTD1 EPB41L5 ARID5B UBR5 DKFZp686L2367 PBX3 HMGA2 GDF3 BCORL1 SMAD6 ZFHX4 TRERF1 SESN1 EXT1 EXT2 AMH TRIM71 SCHIP1 PHF6 CSRP2 TRIM5 ZIC3 C1QBP JARID2 MSGN1 TET1 PARP8 NR1B3 OBFC2B TOX3 PPP2CA ARL4A AEBP2 RARB DKFZp586H0919 AHDC1 C9orf72 WDCP AXIN1 ELP4 AXIN2 ACVR2A PRKAR1A MEIS1 TBX3 RGS10 PBX1 CUL4B SLC2A12 FGFR1 POU5F1 FGF8 SMAD2 HAND1 ATP8B2 CTBP2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA/BETA COMPLEX%WIKIPATHWAYS_20220510%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha/beta complex FOXO3A GABPB2 BCL2 ZFX GABPA SMAD4 MCL1 BCL2L1 DNMT3B TERF2 EP300 CREBBP ATM SMARCA4 PTEN FLT3 ETV6 NCRNAS INVOLVED IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20220510%WP4336%HOMO SAPIENS ncRNAs involved in Wnt signaling in hepatocellular carcinoma LRP5 NKD1 NKD2 PORCN WIF1 RYK FOSL1 FZD10 DVL1 WNT10B CTNNB1 DVL2 TCF7L1 NOTUM CSNK1A1L WNT16 WNT1 KLF4 FZD3 WNT3A CCND1 WNT11 FZD1 FZD2 SFRP1 FZD5 CCND2 FZD7 FZD9 FZD8 CSNK2A1 JUN WNT4 CSNK1A1 CCND3 ELAVL1 GSK3B DKFZp586H0919 APC AXIN1 WNT5B WNT3 TCF7L2 SOX7 WNT10A WNT2B DKK1 LRP6 DKFZp586M1622 WNT7B WNT7A EZH2 FRAT1 MTDH CHD8 FRAT2 SOX17 SOST CER1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E SENP2 DKK4 DKK2 SFRP4 SFRP5 CSNK2B ROR1 CTBP2 ROR2 CTBP1 MYC NLK CXXC4 COPPER HOMEOSTASIS%WIKIPATHWAYS_20220510%WP3286%HOMO SAPIENS Copper homeostasis GSK3B MT2A APC FOXO3A ADAM10 MDM2 PIK3CA STEAP3 COX17 ATP7B CCND1 ATP7A COX11 PRNP CASP3 SLC31A2 SLC31A1 SLC11A2 COMMD1 MT4 HEL-S-44 MT3 STEAP4 ATOX1 CCS PTEN MT1A SCO1 MTF1 SCO2 MT1F MT1G ADAM9 MT1B STEAP1 XAF1 STEAP2 MT1E FOXO1 ADAM17 JUN KIAA1149 APP SP1 ALZHEIMER'S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20220510%WP2059%HOMO SAPIENS Alzheimer's disease and miRNA effects PIK3R2 PPIF PIK3R1 RTN3 PSEN2 KLC4 KLC3 KLC2 ATP5MK SHFM1 FZD10 TUBA2 TUBA8 CHPF2 SLC25A5 WNT16 SLC25A6 TUBAL3 BECN2 AMBRA1 DKFZp779O2152 ADRM1 WNT11 SLC25A31 FZD1 FZD2 FZD5 FZD7 FZD9 PIK3CD FZD8 APC2 CSNK1A1 MAPK3 WIPI1 ATP2A2 APC RB1CC1 RELA WNT5B CASP9 WNT3 GNAQ WNT10A RYR3 C12orf44 WIPI2 ATG14 DKK1 WNT2B NOS2 BAD GRIN2B CACNA1D ATG2A GRIN1 CACNA1F PSMD12 HEL-S-276 HEL-S-91n LRP6 CACNA1S CYCS CALM3 WNT7B PSMD13 CALM2 WNT7A IRS1 CSF1 PSMB6 PSMD9 PSMD6 PSMD7 PSMD4 FRAT2 PSMB2 IL1A PSMB3 IL6 PSMD2 CSNK2A3 ERN1 PSMD3 CSNK2A2 KIAA1149 PSMD1 CSNK1E ATF4 PSENEN DKK4 DKK2 SFRP4 CSNK2B PSEN1 MAPK8 PSMA4 PSMC6 PSMC4 PSMA2 PSMC1 XBP1 INSR EIF2S1 CTNNB1 HEL-S-162eP hCG_16983 CSNK1A1L APOE RTN4 HEL-S-61 TMEM49 CASP3 SNCA TRAF2 TNFRSF1A WNT4 APP ARAF DKFZp781H1925 FAS CALML6 ITPR2 CALML3 CALML4 PLCB2 DKFZp586M1622 PPP3CA IL1B PLCB1 PPP3R1 PTGS2 MCU VDAC3 CASP12 SLC25A4 INS ADAM10 WNT10B DVL1 DVL2 WNT1 TNF-alpha FZD3 DDIT3 WNT3A NAE1 EIF2AK2 HSD17B10 CYBB ULK2 ULK1 PLCB3 PLCB4 LRP5 MAP2K1 CACNA1C CHUK BRAF NFKB1 IKBKB MAPK9 PIK3CA MAPK1 AKT3 HRAS CSNK2A1 MAP3K5 ADAM17 CDK5 FADD MAPK10 GSK3B AXIN1 APAF1 AXIN2 CDK5R1 NRAS LPL MTOR KRAS FRAT1 APH1B PPP3R2 NRBF2 CHRFAM7A ATG2B IDE TUBA1C TUBA1B TUBA1A PPP3CC MME GPR83 TUBB TUBB2A KNS2 MAP2K2 PSMA8 TUBA3E TUBB4B TUBB4A RAF1 IRS4 TUBB8 TUBB6 PIK3R4 TUBB1 KIF5A PIK3R3 TUBA4A GPR40 PATHWAY%WIKIPATHWAYS_20220510%WP3958%HOMO SAPIENS GPR40 pathway FFAR1 PLCZ1 PLCG2 PLCB1 PLCB2 PLCB3 PLCE1 PLCL1 PLCH1 GNA11 PLCD3 DKFZp434N101 PKD1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20220510%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups GLUD1 ASL OTC ARG2 NAGS HEL-S-20 HEL-S-29 SRM SMS ALDH18A1 HEL-S-5 ASS ARG1 GDNF SIGNALING%WIKIPATHWAYS_20220510%WP5143%HOMO SAPIENS GDNF signaling IL8 ST3GAL1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20220510%WP4565%HOMO SAPIENS Neural crest cell migration in cancer STAT3 PIK3R5 ARHA FOS KIDINS220 SORT1 PIK3CA ARF1 TRIO CDH11 BDNF F2RL2 PIK3CD EPHB6 TWIST1 EPHB1 EPHB3 RAC1 AKT3 EPHB4 MMP9 TIAM1 JUN EPHB2 PAK1 NTRK2 PAK6 NGFR MMP2 PAK4 PIK3R4 PIK3R3 IL-17 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2112%HOMO SAPIENS IL-17 signaling pathway STAT3 NFKBIB GSK3B NFKB1 IKBKB RELA PIK3CA IL17B MAPK1 IKBKG IL17F TRAF3IP2 JAK1 IL17RC IL17RB IL25 IL17RA IL17D IL17C IL17A MAP3K7 TRAF6 TRAF3 SP1 MAPK3 DKFZp686J04131 CEBPB CEBPD INSULIN SIGNALING IN ADIPOCYTES (DIABETIC CONDITION)%WIKIPATHWAYS_20220510%WP3635%HOMO SAPIENS Insulin signaling in adipocytes (diabetic condition) RPS6 IRS1 INSR SLC2A4 MTOR TBC1D4 RPS6KB1 SARS-COV-2 B.1.1.7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20220510%WP5116%HOMO SAPIENS SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation MAVS TOMM70 IRF3 TRAF3 IF1DA1 DDX58 TBK1 TRAF6 IKBKE SARS-COV-2 INNATE IMMUNITY EVASION AND CELL-SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20220510%WP5039%HOMO SAPIENS SARS-CoV-2 innate immunity evasion and cell-specific immune response NFKB1 hCG_16983 TNF-alpha TFAP2A EP300 IFITM1 TBK1 TRAF2 MX1 JAK1 TLR7 IFNAR2 CXCL9 IF1DA1 CXCL6 CXCL17 STAT1 CXCL3 DDX58 CXCL13 CXCL5 STAT2 IFIT2 AP1G1 TRIM25 TRAF6 HAVCR2 ACE2 IRF7 LAG3 MAVS IRF3 hEMMPRIN TGFB1 TRAF3 TRAF5 NUP98 LGP2 LARP1 IFNAR1 CCL5 RAE1 CCL4 CD160 CCL3 PPBP RIPK1 TP53I3 FADD PF4 CXCL10 CXCL11 IL8 TANK TRADD CSF2 CXCL1 CXCL2 IL10 IL6R IL6 CXCL12 CCL2 HDAC2 IL8RB IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20220510%WP2007%HOMO SAPIENS Iron metabolism in placenta SLC40A1 STEAP3 MCOLN1 HAMP HEL60 SLC11A2 TF HEPHL1 TFR2 FTH1 DKFZp686O0451 IREB2 LET-7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20220510%WP3299%HOMO SAPIENS let-7 inhibition of ES cell reprogramming TRIM71 POU5F1 EGR1 KLF4 MYC SOX2 FERROPTOSIS%WIKIPATHWAYS_20220510%WP4313%HOMO SAPIENS Ferroptosis HEL-S-64p GPX4 AKR1C1 AKR1C2 SLC39A8 DKFZp727E011 FTL HMOX1 POR CTH ACSL1 CYBB FACL4 ACSL5 GCLC ACSL3 TF DKFZp686O0451 GCLM IREB2 SLC40A1 BACH1 SAT2 MAP1LC3A SLC7A11 MAP1LC3C AIFM2 C10orf70 DKFZp762B153 CHMP6 CHMP5 SLC3A2 DPP4 PCBP1 PHKG2 LPCAT3 STEAP3 PRNP CP SLC11A2 HEL-S-102 SLC39A14 ATG5 HMGCR FDFT1 VDAC3 SLC38A1 ALOX15 FTH1 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20220510%WP3871%HOMO SAPIENS Valproic acid pathway HADHB IVD CYP2B6 EHHADH UGT1A3 CYP2C9 HSD17B10 CYP2A6 HDAC1 ABAT ACADSB SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20220510%WP1455%HOMO SAPIENS Serotonin transporter activity MAOA STX1A IL1R1 TGFB1I1 ITGB3 IL1B TPH2 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway IL12B PTGES3 CYP1B1 IL12A CDKN1B JUNB IL17B TNF-alpha AHR NCOA1 CDC37 POLK CES3 SERPINB2 EP300 UGT1A1 MGST1 IGFBP1 MYOF AIP ALDH3A1 SLC7A5 IL1B SRC AHRR JUN DKFZp686D0714 JUND TGFB1 UGT1A4 IL2 EGFR HES1 UGT1A3 UGT1A9 UGT1A7 IF2F NQO1 CYP1A2 CYP1A1 BAX NFE2L2 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20220510%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFV3 NDUFV2 NDUFV1 NDUFA13 NDUFAF7 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 NDUFA3 NDUFA2 NDUFAB1 TMEM186 DKFZp564J0123 ACAD9 ND1 ECSIT TMEM126B ND2 ND5 ND4 NDUFAF2 ND6 DMAC1 NDUFAF1 DMAC2 TMEM70 COA1 TIMMDC1 ND4L NDUFAF6 NDUFAF4 NDUFA12 NUBPL NDUFA10 NDUFB10 NDUFB11 GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20220510%WP2854%HOMO SAPIENS Gene regulatory network modelling somitogenesis MESP2 WNT3A LFNG EPHA4 RIPPLY2 TBX6 HES1 NOTCH1 FGF8 HES7 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20220510%WP1772%HOMO SAPIENS Apoptosis modulation and signaling IL1R1 FOS NFKB1 hCG_16983 IKBKB TNFSF6 hCG_20684 BCL2 BBC3 CASP6 CASP3 TNFRSF1A NAIP MAP3K5 JUN DKFZp686A24188 TRAF6 PIDD1 TRAF3 IRAK1 PMAIP1 RIPK1 FADD MAPK3 BCL2A1 BCL2L10 FAS BCL2L2 CASP10 BOK MYD88 AIFM2 TNFRSF1B APAF1 MADD CASP9 BAK1 BAD BLK BCL2L11 NFKBIA TRADD DIABLO CYCS HTRA2 HRK TNFRSF6B CAPNS1 AIFM1 CASP4 TNFSF10 DFFB BIRC2 DFFA BIRC3 IL1R2 PTRH2 TNFRSF25 BIRC7 BAG3 BMF MCL1 CRADD BCL2L1 BIK CDKN2A BNIP3 TNFRSF10C TNFRSF10A SEPTIN4 PTPN13 TNFRSF10D BIRC5 PRKD1 DKFZp686J04131 MAPK8 BAX DNA MISMATCH REPAIR%WIKIPATHWAYS_20220510%WP531%HOMO SAPIENS DNA mismatch repair POLE MSH6 RPA3 POLE2 RFC3 RFC4 POLD3 POLD4 RFC1 POLD2 RPA1 PCNA MSH2 DKFZp686J1569 LIG1 RFC2 POLE4 POLE3 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20220510%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CYS1 SCOTIN SESN3 ZMAT3 CHEK2 PERP hCG_16983 APAF1 MDM2 DDB2 CASP9 DKFZp686A24188 TP53AIP1 BBC3 SIAH1 CASP3 PMAIP1 ATM SERPINE1 PTEN EI24 BAX ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20220510%WP5136%HOMO SAPIENS ALA oxylipin metabolism EPHX2 ALOX5 ALOX15 DNA IR-DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20220510%WP3959%HOMO SAPIENS DNA IR-double strand breaks and cellular response via ATM BRCA1 OBFC2B CHEK2 MDC1 RAD51 RIF1 RNF8 RASSF1 HSF1 APAF1 MDM2 TP53BP1 CASP9 HTATIP TP73 BAK1 MCPH1 PRKDC CHEK1 RAD52 RAD50 CASP3 ATF2 ATR MRE11A TERF2 RAD9A H2AX ATM NBN BRCA2 TRIM28 SMC1A PARP1 LATS1 TRAF6 ACTL6A DKFZp451O0517 CDKN2A RAD17 CDK5 FANCD2 SMC3 PCNA BLM BAX OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP5094%HOMO SAPIENS Orexin receptor pathway PIK3R2 PIK3R1 OPN3 FOSB EGR2 NR4A3 KLF4 TNF-alpha KCNK3 RARA CLDN4 NOG FSHB LHB DBP CGA BHLHB2 SKIL GNRH1 MAFF MAPK3 VEGFA HIF1A NFE2L2 CTGF OPRK1 HCRTR2 HCRTR1 KLF10 SELE SLC2A4 NSMAF RUNX2 ID1 BMPR1A RRM2 ID4 GRIN2B GRIN1 AVP CDKN1A NPFFR1 CXCL2 IL10 HSD3B2 IL4 IL6 HES1 IRF5 COX7A1 MYC HEL-S-89n JUNB VCAM1 HEL-S-133P FOS BGLAP SP7 SPP1 YARS2 MAPK1 GJA3 DIPLA1 NPAS4 CLEC4C TFAM SLC1A2 GLIS1 HCRT BTF3 OSBPL3 DCLK1 IL9 ID3 CD24 TRIM9 SERP1 OPA1 DUSP4 MMP3 TENT5A CRH LUZP1 CXXC5 TOX PPOX PPM2C PDE11A LDLR NPVF NOCT EGR1 LRRC8C VHL HMGA2 FLJ23306 RUNX1T1 HAGHL HSU53209 GADD45B ZFP28 JARID2 HMGA1 SGK1 LEP IL8 PPARG PRKCA CYP11A1 ARC TNC STAR GRIA2 CYP21A2 UCP1 CYP11B2 PRDM16 HOMER1 LPL GH1 PER2 IL1B FLT4 CALCA HBEGF RUNX1 CEBPA 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome GATA3 IL1R1 hCG_22119 TULP1 MAPK1 IL23A RAC1 SOCS1 STAT1 CXCL13 MERTK CHTM1 IL1RN ZC3H8 IL2 ZNRD1 IL36A ARF6 IL36B PSD4 ARL14 CKAP2L POLR1A IL1F5 POLR1C POLR1D DKFZp666O0110 POLR1F POLR1G FBLN7 TMEM87B SLC20A1 ANAPC1 RGPD8 TTL IL1RL2 POLR2F POLR2H POLR2K POLR2L IL37 IL36G IL1F10 GAS6 BCL2L11 GRB2 CSF2 CSF1 IL1B PLCG2 IL1A IL6 SOCS3 MIR-222 IN EXERCISE-INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20220510%WP3938%HOMO SAPIENS miR-222 in exercise-induced cardiac growth CDKN1B HMBOX1 HIPK2 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20220510%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CCND1 CHEK1 SKP2 SIN3A CDK6 CCNE1 CDC2 HMGB1 SMC3 CDK4 PCNA CCND3 RB1 DKFZp686G14213 CCNE2 CDKN1B BARD1 MSH6 MDM2 PLK4 CCNB2 TYMS CCNB1 PRKDC FAF1 HMGB2 POLD3 SMC2 MCM7 PRMT2 ORC1L SAP30 RRM1 RBP1 RRM2 CDK2 NPAT RPA1 HLTF RBBP7 CDT1 CCNA2 DKFZp686M1631 MAPK13 DHFR CCDC6 FANCG TFDP1 POLA1 TFDP2 SMC1A RBBP4 CDKN1A MCM6 TOP2A TTK POLE CDC45 PRIM1 E2F2 E2F3 RPA3 POLE2 RFC3 WEE1 RFC4 SUV39H1 H2AZ1 RAF1 HDAC1 MYC TRANS-SULFURATION PATHWAY%WIKIPATHWAYS_20220510%WP2333%HOMO SAPIENS Trans-sulfuration pathway MTR DKFZp727E011 AHCY pcap GCLM CTH METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20220510%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MSRA IL4I1 MTAP MTR ADI1 MSRB2 MSRB3 DKFZp686G18136 ENOPH1 AHCY HEL-S-61p MAT1A CHDH SRM SMS TXN APIP MRI1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20220510%WP3407%HOMO SAPIENS FTO obesity variant mechanism PRDM16 TBX1 IRX5 IRX3 PPARGC1A ARID5B UCP1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20220510%WP561%HOMO SAPIENS Heme biosynthesis ALAS1 PPOX ALAS2 UROD UROS HMBS CPOX DKFZp686P18130 TNF-RELATED WEAK INDUCER OF APOPTOSIS (TWEAK) SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2036%HOMO SAPIENS TNF-related weak inducer of apoptosis (TWEAK) signaling pathway CHUK NFKBIB GSK3B MAPK14 TRAF1 NFKB1 CTNNB1 hCG_16983 IKBKB RELA MAPK9 TNF-alpha MAPK1 CASP3 NFKBIA TRAF2 RAC1 MMP9 MAP3K7 BIRC2 BIRC3 JUN RELB IL6 TWEAK TNFRSF12A TRAF3 TRAF5 CCL2 TRIM63 NFKB2 CCL5 RIPK1 RAF1 FADD MAPK3 HDAC1 DKFZp686J04131 MAPK8 IL-5 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP127%HOMO SAPIENS IL-5 signaling pathway PIK3R2 PIK3R1 STAT5B STAT3 MAP2K1 SOS1 GSK3B PTPN11 FOS FOXO3A SHC1 BCL2 GSK3A MAPK1 RPS6KB1 RPS6KB2 KRAS JAK1 GRB2 RPS6KA1 STAT1 JUN CSF2RB SYK SPRED1 LYN RPS6 IL2 MAP2K2 RAF1 MAPK3 BTK IL5RA MYC WNT SIGNALING%WIKIPATHWAYS_20220510%WP428%HOMO SAPIENS Wnt signaling FZD10 DVL1 WNT10B DVL2 TCF7L1 WNT1 WNT16 DAAM1 FZD3 WNT3A CCND1 WNT11 FZD1 FZD2 SFRP1 FZD5 PRKCB CCND2 FZD7 FZD9 FZD8 RAC1 ROCK2 CSNK1A1 ARHA APC CAMK2D CAMK2A WNT5B NFATC1 NFATC2 WNT3 WNT10A CAMK2G DKK1 WNT2B INVS LRP6 WNT7B WNT7A CHD8 FRAT2 SOX17 SOST CER1 CSNK2A3 CSNK2A2 PLCB3 CTNNBIP1 PLCB4 KREMEN1 CSNK1E DKK4 SENP2 DKK2 SFRP4 SFRP5 CSNK2B ROR1 ROR2 CTBP1 MAPK8 MYC NLK CXXC4 LRP5 NKD1 NKD2 PORCN WIF1 RYK FOSL1 CTNNB1 NOTUM MAPK9 CSNK1A1L MAP3K7 CSNK2A1 JUN WNT4 NFATC4 CCND3 PRKCA GSK3B DKFZp586H0919 AXIN1 PLCB2 TCF7L2 DKFZp586M1622 PPP3CA FRAT1 PPP3R2 PLCB1 PPP3R1 PPP3CC DAAM2 VANGL1 PRICKLE2 GPC4 NFATC3 CTBP2 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20220510%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4538%HOMO SAPIENS Regulatory circuits of the STAT3 signaling pathway IL9R CTF1 STAT3 IL20RA IL20RB CSF2RA IL10RB IFNLR1 MAPK14 MAPK15 IL22RA1 MAPK9 IL10RA MAPK1 IL21R PRKCB raptor TRIM28 DKFZp686M02159 JAK1 IFNAR2 MLST8 PTPRC JAK3 IL2RB TYK2 IFNAR1 MAPK6 MAPK4 IL2RA OSMR MAPK3 IL7R MAPK10 DEPTOR AKT1S1 MAPK7 RICTOR CSF3R hCG_2011440 IL6ST IL2RG MAPKAP1 F2RL2 F2RL3 MTOR MAPK13 MAPK11 GHR F2R IL3RA IL6R SRC CSF2RB PDGFRA EGFR AGTR1 AGTR2 CREBBP PTPRT CNTFR IFNGR1 SETD7 IFNGR2 MPL IL27RA SOCS3 MAPK8 IL5RA IL15RA DUSP2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20220510%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY6 P2RY4 LTB4R P2RY2 LPAR4 ADORA2A P2RY1 ADORA2B MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20220510%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer MAP2K1 SOS1 SOS2 BRAF ALK FOS GAREM2 JUN SHC1 MAP2K2 RAF1 MAPK3 KSR1 MYC KRAS STEROID BIOSYNTHESIS%WIKIPATHWAYS_20220510%WP496%HOMO SAPIENS Steroid biosynthesis CPN1 CYP17A1 F13B HSD17B2 hCG_2024989 HSD3B2 HSD3B1 HSD17B3 HSD17B1 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP673%HOMO SAPIENS ErbB signaling pathway PIK3R2 PIK3R1 STAT5B MAP2K1 BRAF MAPK9 PIK3CA AREG NRG2 EREG MAPK1 CRKL BTC NRG4 ABL2 CCND1 PRKCB NRG3 PIK3CD ERBB4 TGFA AKT3 HRAS MAP2K4 CRK NCK2 FOXO1 JUN SHC4 SHC2 SHC3 ERBB3 PAK1 PAK6 MAPK3 ARAF PAK4 CBL EGF MAPK10 DKFZp666O0110 SOS1 SOS2 GSK3B CDKN1B PRKCA PDPK1 CAMK2D CAMK2A MDM2 SHC1 NRAS CAMK2G BAD DKFZp434N101 BCL2L11 MTOR RPS6KB1 NRG1 RPS6KB2 KRAS CDKN1A GRB2 PLCG2 SRC HBEGF MAP2K2 EGFR NCK1 RAF1 MAPK8 MYC ERBB2 PIK3R3 EIF4EBP1 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP304%HOMO SAPIENS Kit receptor signaling pathway PIK3R2 PIK3R1 STAT5B STAT3 MAP2K1 JUNB PTPN11 FOS MAPK14 MITF-C KITLG BCL2 MAPK1 CRKL GRB10 MATK DOK1 SOCS6 PRKCB EP300 KIT SNAI1 RPS6KA3 INPP5D RPS6KA1 VAV1 SOCS1 HRAS STAT1 CRK GAB2 RPS6 LYN TEC BTK MAPK3 TBX2 CBL PTPN6 SNAI2 SOS1 PRKCA SH2B2 FOXO3A SHC1 BAD DKFZp434N101 RPS6KB1 GRB2 SRC FYN MAP2K2 RAF1 GRB7 MAPK8 SARS-COV-2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20220510%WP5156%HOMO SAPIENS SARS-CoV-2 replication organelle formation ZFYVE1 ATG14 PIK3R4 AMBRA1 GASTRIN SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4659%HOMO SAPIENS Gastrin signaling pathway PIK3R2 PIK3R1 STAT3 HDAC7 KLF4 CCND1 MEF2C SLC9A3 PRKD2 ARHGEF28 ARRB2 MMP7 ANXA2 CD44 RHOD TFF2 TCF4 HDC RAC1 CRK ROCK1 FOXO1 CDC42 YES1 PAK1 IL2 PRKCQ SP1 MAPK3 VEGFA DKFZp666O0110 MEF2D ARHA PRKCH RELA PRKCE GNAQ GAS BAD BMP2 CREB1 NFKBIA MEF2B CDKN1A IRS1 BIRC2 BIRC3 SRC BCL2L1 ITGB1 BIRC5 MAPK8 MYC EIF4EBP1 MAP2K1 CHUK PTPN11 FOS MAPK14 NFKB1 CTNNB1 IKBKB MAPK9 HTATIP PIK3CA MAP3K11 MAPK1 CASP3 ATF2 SERPINE1 KIT HRAS EGR1 JUN RPS6 CCKBR CLDN1 DKFZp686A1195 ELAVL1 IL8 PPARG SOS1 PRKCA GSK3B CDKN1B FOXO3A SHC1 SERPINB2 DKFZp434N101 MTOR RPS6KB1 KRAS GRB2 RHOB FYN PTGS2 CDKN2A EGFR RAF1 PRKD1 PXN PIK3R3 LAMTOR3 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20220510%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals PRKCA SLC7A11 HMOX1 PIK3CA EPHB2 MAF GCLC KEAP1 NQO1 AIMP2 MAPK8 CEBPB GCLM NFE2L2 RAS SIGNALING%WIKIPATHWAYS_20220510%WP4223%HOMO SAPIENS Ras signaling PIK3R2 PIK3R1 RRAS GNG12 ABL2 PLCE1 RALBP1 FGFR4 FGFR3 GNG2 PRKCB FGFR2 PIK3CD RIN1 ETS2 FOXO4 DKFZp667A016 RAC3 PLA2G10 PLD2 RAC1 HRASLS3 PLA2G3 RAP1A RASAL1 RRAS2 RASAL3 STK4 IGF1R TTBK1 RASGRP4 RASGRP3 DKFZp781H1715 AFDN RGL2 PLA2G12A PLA2G4F RASA4B PLA2G12B GAB2 PLA2G4D PLA2G4E CDC42 PLA2G4C RASA4 PAK1 PLA2G1B PAK6 SHOC2 LAT ARF6 PLA2G2F RALA PLA2G2D RALB PLA2G2E PLA2G2C RAB5B ZAP70 MAPK3 RAB5C PAK4 KDR ARHA KSR2 PRKACG RELA PLA2G6 BAD GRIN2B GRIN1 RAB5A CALM3 EXOC2 CALM2 PLA2G5 PLA2G4B HTR7 PLCG2 BCL2L1 RASA2 MAPK8 MAP2K1 CHUK PTPN11 INSR NFKB1 RASSF1 GNGT1 IKBKB TNFSF6 MAPK9 PIK3CA GNB1 MAPK1 IKBKG EPHA2 CSF1R FLT1 KIT PLA1A AKT3 HRAS TIAM1 SHC4 SHC2 SHC3 NGFR GNG11 GNG13 GNGT2 hCG_1994888 RASGRF1 MAPK10 KSR1 SYNGAP1 CALML6 SOS1 SOS2 CALML3 PRKCA CALML4 NTRK1 SHC1 REL NRAS NF1 DKFZp434N101 GNB2 GNB4 GNB3 GNB5 FLT3 KRAS GRB2 FGFR1 FLT4 GNG3 GNG5 GNG4 GNG7 NTRK2 PDGFRA GNG8 MAP2K2 EGFR RAF1 PLA2G2A RASA3 PIK3R3 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20220510%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide FAS TGFB1 IL12A CD80 IL2 IL10 VIP IL4 IF2F CTLA4 IL5 HAIR FOLLICLE DEVELOPMENT: ORGANOGENESIS - PART 2 OF 3%WIKIPATHWAYS_20220510%WP2839%HOMO SAPIENS Hair follicle development: organogenesis - part 2 of 3 LRP5 NCAM1 DKFZp586H0919 NFKB1 CTNNB1 RUNX2 SMO CCND1 FZD1 PTCH1 FGFR2 CCND2 BMP4 SNAI1 INHBA LAMA5 TP63 ITGB1 PDGFRA EDAR SHH TNLG7C FOXI3 GTPBP4 GJB6 PDGFA MYC LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20220510%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 LEPR PRKAG1 ADIPOR1 ADIPOR2 PRKAB1 LEP ACACA PHOTODYNAMIC THERAPY-INDUCED NF-KB SURVIVAL SIGNALING%WIKIPATHWAYS_20220510%WP3617%HOMO SAPIENS Photodynamic therapy-induced NF-kB survival signaling IL8 BCL2L2 CHUK VCAM1 NFKB1 SELE IKBKB RELA TNF-alpha REL CCND1 TNFRSF1A MMP3 CSF2 MMP9 CXCL2 IL1B BIRC2 BIRC3 IL1A RELB IL6 TRAF6 PTGS2 IL2 NFKB2 MMP2 VEGFA BIRC5 BCL2A1 CD40LG EGLN2 CORI CYCLE%WIKIPATHWAYS_20220510%WP1946%HOMO SAPIENS Cori cycle PFKP GPT INS HEL-S-87p SLC2A2 HEL-S-133P HEL-S-68p SLC2A4 HEL-S-162eP HEL-S-49 PGAM1 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20220510%WP1604%HOMO SAPIENS Codeine and morphine metabolism CYP2C8 UGT2B4 UGT2B7 SLCO1B1 UGT1A10 CYP3A4 ABCC3 ABCC2 ABCB1 UGT1A1 UGT1A3 UGT1A9 UGT1A8 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20220510%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis PPARG IRS1 INSR SLC2A4 PPARGC1A FOXO1 LPIN1 TNF-alpha IL6 NR3C1 PCK2 CREB1 RXRA CEBPA TWIST1 MAPK8 CEBPB LEP CEBPD ONE-CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20220510%WP3940%HOMO SAPIENS One-carbon metabolism and related pathways DHFR2 AHCYL1 HEL-S-64p CBS GPX1 CEPT1 PCYT1B GPX4 AGXT2 hCG_16873 BHMT2 PCYT2 GPX7 HEL-S-182mP ETNK1 PEMT CDO1 CHPT1 CHKA TYMS HEL-S-61p MAT1A CHDH GPX2 GPX3 HEL-S-44 pcap GPX6 GAD2 MTR BAAT BCAT1 HEL-75 BCAT2 SHMT1 HEL-S-51e DKFZp564M2422 CTH GAD1 GCLC GCLM HEL-S-75p NEPHROGENESIS%WIKIPATHWAYS_20220510%WP5052%HOMO SAPIENS Nephrogenesis FGF4A MEIS1 OSR1 GREB1L TCF21 PAX2 FGF8 SIX2 RSPO3 RSPO1 WNT3A ALDH1A2 DKFZp434N181 WNT4 FOXD1 WNT9B FOLLICLE STIMULATING HORMONE (FSH) SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2035%HOMO SAPIENS Follicle stimulating hormone (FSH) signaling pathway PRKCA MAPK14 CGA SRC AREG FOXO1 MAPK1 H3-4 RPS6 APPL1 BDNF FSHR TSC2 MTOR CREB1 RAF1 FSHB MAPK3 RPS6KB1 SGK1 RHEB RPS6KB2 EIF4EBP1 ONE-CARBON METABOLISM%WIKIPATHWAYS_20220510%WP241%HOMO SAPIENS One-carbon metabolism MTR MTHFD1 FTCD MTHFD2 SHMT1 HEL-S-51e AHCY MTHFS TYMS HEL-S-61p MAT1A CHDH MTFMT DNMT3B hCG_2001997 AHCYL2 HEL-S-70p FOLH1B GLRX FOLH1 DHFR MTHFD1L MTRR TCN2 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20220510%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MYRIP SYTL5 DKFZp781H0795 UNC13D TBC1D10A SYTL2 MADD RPH3A MLPH SYTL1 RAB27A RAB27B MONOAMINE TRANSPORT%WIKIPATHWAYS_20220510%WP727%HOMO SAPIENS Monoamine transport STX1A IL1R1 TGFB1I1 SLC6A1 TDO2 MAPK14 SLC6A2 SLC6A3 TNF-alpha SLC5A7 RBL2 TH ACHE DBH NECTIN2 ITGB3 IL1B ADORA2A TSC2 AMPH FBXO32 UNC13B HRH3 TNFRSF11B TPH2 SYN1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20220510%WP12%HOMO SAPIENS Osteoclast signaling TNFSF11 IF1DA1 ATP6V1G1 ITGB3 TNFRSF11A CTSK SPP1 ACP5 TRPV5 IFNAR1 GPR68 TNFRSF11B AIMP2 MAPK8 HIPPO-YAP SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4537%HOMO SAPIENS Hippo-Yap signaling pathway MAP4K2 TEAD4 RASSF1 LATS1 LATS2 TAFAZZIN MAP4K1 HEL-S-31 MINK1 TEAD2 STK38L TEAD3 TNIK NF2 YWHAQ YY1AP1 CXCL10 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20220510%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways PIK3R2 STAT3 DVL1 FGF23 WNT10B DVL2 FGF22 ACTR2 WNT1 WNT16 FZD3 WNT3A FGF1B FGF1A WNT11 FZD1 FZD2 FGFR4 FZD5 FGFR3 FZD4 FGFR2 NOG FZD7 BMP4 FZD9 PIK3CD FZD8 JAK1 FGF7B MAP2K5 FGF7A HNF1A FGF6B FGF6A MAPK6 MAPK4 EGF FGF13 MAPK7 FGF5C FGF5B FGF5A APC MDM2 WNT5B IL6ST WNT3 SMAD4 WNT10A SMAD1 SMAD9 BMPR1A WNT2B BMPR2 WNT9B DKFZp781O1323 LRP6 WNT7B WNT7A SELENOP LIF ERAS LRP5 MAP2K1 BRAF PTPN11 FOS CTNNB1 MAPK1 FGF8C ACVR1 DKFZp686M02159 AKT3 HRAS MAP2K3 JUN SMAD6 WNT4 ARAF MAP2K6 SOS1 GSK3B AXIN1 FGF8A MTOR PTEN DKFZp586M1622 GRB2 FGFR1 FGF4B FGF4A FGF2 FGF4C FGF8 PDGFRA MAP2K2 EGFR RAF1 PDGFA ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2881%HOMO SAPIENS Estrogen receptor pathway STAT3 CYP1B1 NR0B2 ACOX1 NR1C1 PCK1 GPAM SP1 JUN CYP1A2 CYP1A1 PDK4 SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20220510%WP4539%HOMO SAPIENS Synaptic signaling pathways associated with autism spectrum disorder PIK3R2 PIK3R1 CACNA1C GSK3B PRKAA1 ARC PRKAA2 PIK3CA MAPK1 UBE3A NRAS HOMER1 BDNF NF1 raptor PIK3CD GRIN2B MTOR PRKAG1 GRIN1 PRKAG2 DLG4 PRKAG3 RPS6KB1 PTEN RHEB KRAS AKT3 HRAS PRKAB2 NTRK2 TSC2 GRIN3B GRIN3A TSC1 CAMK4 MAPK3 PRKAB1 SYNGAP1 PIK3R3 EIF4EBP1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20220510%WP2361%HOMO SAPIENS Gastric cancer network 1 SMOC2 S100P CASTOR3 HIST1H4J KIF20B APC CENPF TOP2A MYBL2 RUVBL1 UBE2C ACTL6A NUP107 NOTCH1 INO80D LIN9 HCTP4 KIF15 KIAA1569 H3F3A ESM1 AURKA ECT2 E2F7 GATD3 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20220510%WP550%HOMO SAPIENS Biogenic amine synthesis TPH1 PNMT AANAT ACHE PAH DBH ChAT DDC ASMT MAOA GAD1 TH HDC GAD2 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20220510%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway NTF5 FGF5A INS CXCR1 KITLG CNTF FST IGF1 GDF5 WNT1 IL11 WNT3A WNT2B DKK1 NOG BMP4 CSF1R KIT LEFTY1 INHBA HGF WNT7B NODAL TNFSF11 ALK CSF1 FGF7A EPO FGF2 IL6R NT5E IL3 FGF8 FLT3LG IL6 TGFB1 SHH NOTCH1 VEGFA TPO TF EGF PDGFA FATTY ACID OMEGA-OXIDATION%WIKIPATHWAYS_20220510%WP206%HOMO SAPIENS Fatty acid omega-oxidation ADH6 ADH1C HEL-S-4 ADH1B ADH1A CYP3A4 HEL-S-53e ALDH2 CYP4A11 CYP2A6 CYP2E1 CYP1A2 CYP1A1 ADH7 ELECTRON TRANSPORT CHAIN: OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20220510%WP111%HOMO SAPIENS Electron transport chain: OXPHOS system in mitochondria SLC25A4 NDUFV3 NDUFV2 NDUFV1 SLC25A5 UQCRQ SLC25A6 CYTB hCG_39985 ATP5G1 COX7B HEL-S-271 COX4I1 ATP5IF1 ND3 COX7C SLC25A14 COX17 ATP8 ATP6 COX11 ATP5MC2 ATP5J UQCRFS1 ATP5H COX8A HEL-S-123m SLC25A27 UCP2 SURF1 NDUFC2 ATP5MG ATP5MF NDUFC1 ATP5ME DMAC2L NDUFS8 ATP5F1D NDUFS6 ATP5F1E NDUFS5 ATP5PO NDUFS4 NDUFS3 NDUFS1 COX2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 UQCR10 COX5A NDUFA9 NDUFA7 NDUFA6 NDUFA5 ZNF183 NDUFA4 NDUFA3 NDUFA2 COX6C NDUFAB1 UCP1 ND1 UCP3 ND2 ND5 ND4 ND6 SCO1 ND4L NDUFA12 NDUFA10 COX6A1 COX6A2 SDHC SDHD SDHA SDHB COX6B1 COX7A2L UQCRC1 UQCRC2 UQCRB NDUFB10 COX7A2 COX7A1 UQCRH COX3 COX1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20220510%WP4022%HOMO SAPIENS Pyrimidine metabolism HEL74 ENPP1 ENPP3 ENTPD1 ENTPD3 NME2 CTPS2 NME3 CTPS1 NME4 DCTD NME6 CMPK1 CMPK2 DCTPP1 RP11-311P8.3 DTYMK POLR2A DKFZp686D10173 POLR2B ZNRD1 POLR2C POLR2D NT5M POLR2G POLR2I POLR2J POLR1A POLR2J3 DUT POLR1C PNPT1 POLR1D POLR2J2 POLR1F POLR3GL POLR3A POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2H POLR2K POLR2L CDA DPYS TYMS TYMP POLD3 TK1 POLD4 RRM1 POLD2 RRM2 POLA1 UCK2 UCK1 DPYD UMPS POLE PRIM1 PRIM2A POLA2 POLE2 NME7 CAD POLE4 DHODH POLE3 RRM2B DNA DAMAGE RESPONSE%WIKIPATHWAYS_20220510%WP707%HOMO SAPIENS DNA damage response RAD51 hCG_16983 hCG_37731 TREX1 CCND1 CHEK1 BBC3 CASP3 ATR CCND2 RAD9A DKFZp686A24188 CDK6 HUS1B TP53AIP1 PIDD1 GADD45B SESN1 CCNE1 TLK2 TLK1 RFC1 CDC2 FANCD2 CDK5 PMAIP1 CDK4 PML CCND3 RB1 BRCA1 FAS CCNE2 CHEK2 CDKN1B APAF1 MDM2 CASP9 DDB2 CCNB3 CCNB2 GADD45A CCNB1 PRKDC SFN GADD45G RAD52 RAD50 CDK2 MRE11A H2AX CREB1 ATM NBN SMC1A CYCS CDKN1A RAD17 MYC RRM2B BAX LIDOCAINE METABOLISM%WIKIPATHWAYS_20220510%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20220510%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BRCA1 IL8 STAT3 SOS1 CXCR1 PTPN11 HEL-117 DKFZp586H0919 MAPK14 NFKB1 FRZB TNFSF6 CASP9 SMAD4 CCND1 CASP3 RRM2 NOS2 CD44 MYOF CDKN1A RAC1 JAK1 GRB2 E2F2 IL6R COL4A2 BIRC3 JUN HNF1A IL6 TGFB1 TGFBR1 PTGS2 BCL2L1 VAV2 MAPK3 VEGFA BIRC5 MAPK8 HIF1A MYC HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20220510%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 SEROTONIN RECEPTOR 2 AND ELK-SRF/GATA4 SIGNALING%WIKIPATHWAYS_20220510%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK-SRF/GATA4 signaling MAPKAPK2 MAP2K1 HRAS GATA4 MAPK1 GNAQ NRAS MAP2K2 HTR2B HTR2A RAF1 RASGRF1 MAPK3 KRAS OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION, LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20220510%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation, leading to myelin components for CNS ASCL1 CNTF SOX6 OMG MBP NKX2-2 IGF1 NKX2-6 MOG TNF-alpha BMP4 BMP2 MYT1 CNP CXCL1 SOX5 CXCL2 FGF2 IL1B OLIG1 OLIG2 SOX10 SOX8 SOX9 LIF SHH METABOLIC PATHWAY OF LDL, HDL AND TG, INCLUDING DISEASES%WIKIPATHWAYS_20220510%WP4522%HOMO SAPIENS Metabolic pathway of LDL, HDL and TG, including diseases ABCA1 LDLR APOE APOB MTTP PCSK9 LIPG LIPC LPL ANXA2 APOA2 SCARB1 APOA1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20220510%WP383%HOMO SAPIENS Striated muscle contraction pathway HEL113 ACTA1 MYOM1 HEL-S-273 TNNI1 ACTN4 TNNI2 HEL-S-108 TMOD1 MYBPC3 TNNC1 TNNC2 MYL4 MYL2 DKFZp451M091 MYH6 TNNT1 TNNT3 TNNI3 MYH8 ACTG1 DMD TCAP DKFZp451N061 tmp_locus_29 ACTA2 MYL1 MYL3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20220510%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis PFKP HEL-S-30 HEL-S-87p SLC2A2 PGAM2 HEL-S-133P SLC2A3 HEL-S-68p HEL-S-17 SLC2A4 PFKM HEL-S-162eP HEL-S-49 HEL-S-281 PDHA1 G6PC1 PC GOT2 BRP44 ENO2 ENO3 HK2 HK3 MPC1 DLAT GCK PCK1 PFKL ALDOC ALDOB FBP1 FBP2 MDH2 PKLR DLD HEL-S-32 PGAM1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20220510%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFV3 NDUFV2 NDUFV1 hCG_39985 ATP5G1 HEL-S-271 ND3 ATP6 ATP5MC2 ATP5J ATP5H HEL-S-123m LOC56901 NDUFC2 ATP5MG ATP5MF NDUFC1 ATP5ME DMAC2L NDUFS8 ATP5F1D NDUFS6 ATP5F1E NDUFS5 ATP5PO NDUFS4 NDUFS3 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 NDUFA9 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 NDUFA2 NDUFAB1 ND1 ND2 ND5 ND4 ND6 ND4L NDUFA11 NDUFA10 ATP6AP2 NDUFB10 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20220510%WP3287%HOMO SAPIENS Overview of nanoparticle effects IL8 AKT3 CRP HMOX1 LAMA3 COL4A1 BCL2 NFRKB TNF-alpha IL6 PTGS2 PIK3CD CCND3 PTGS1 DKFZp666O0110 BAX IL-1 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP195%HOMO SAPIENS IL-1 signaling pathway PIK3R2 PIK3R1 TAB3 MAP2K1 MYD88 CHUK NFKBIB MAP3K2 IL1R1 PTPN11 MAPK14 NFKB1 IKBKB RELA MAPK9 MAPK1 IKBKG REL ECSIT ATF2 DKFZp434N101 NFKBIA IRAK3 PRKCZ MAPKAPK2 SQSTM1 MAP3K1 MAP3K7 MAP2K4 IL1B MAP2K3 IRAK4 JUN IL1A HEL-S-71 HSPB2-C11orf52 TRAF6 IRAK2 PELI1 UBE2V1 IRAK1 CCL2 MAP2K2 MAPK3 MAP2K6 DKFZp686J04131 MAPK8 MAP3K7IP1 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20220510%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer ACLY HEL-S-30 HEL-S-133P ME1 CS PDHA1 PGM3 GOT2 KRAS GLUD1 GPT HK2 DLAT BCAT2 PFKL LDLR SLC7A5 HMGCR RPE SLC43A1 GNPNAT1 SLC16A4 PDHX GFPT1 RPIA SOAT1 CARM1 DLD HEL-S-32 GLS2 FASN KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20220510%WP4871%HOMO SAPIENS Kisspeptin/kisspeptin receptor system in the ovary MAP2K1 PRKCA CYP11A1 NFKB1 PRKCH HSD3B1 PRKCE PIK3CA STAR MAPK1 PLCB2 NRAS PRKCB PIK3CD ARRB2 KRAS MMP9 HRAS PLCB1 KISS1 PLCB3 PLCB4 AMH FSHR MAP2K2 PRKCQ RAF1 BMP15 MAPK3 KISS1R GDF9 OVERVIEW OF INTERFERONS-MEDIATED SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4558%HOMO SAPIENS Overview of interferons-mediated signaling pathway IF1IC1 PIK3R1 IF1IA1 IF1EA IFNK PRKCA IL10RB IFNLR1 PIK3CA IFNA4 IFNA1 IF1AA3 IF1AA1 JAK1 IFNAR2 IF1AA6 IFNA13 IF1AA5 IF1DA1 IF1AA4 IFNA14 STAT1 IF1AA9 STAT2 IF1AA8 TYK2 IF1AB4 IRF9 IFNAR1 IF1AB1 IFNGR1 IFNGR2 IF2F IF1IB1 IFNL2 IF1BA1 SEROTONIN RECEPTOR 4/6/7 AND NR3C SIGNALING%WIKIPATHWAYS_20220510%WP734%HOMO SAPIENS Serotonin receptor 4/6/7 and NR3C signaling MAPKAPK2 MAP2K1 RAP1A BRAF HTR4 HTR6 ATF1 HTR7 EGR1 MAPK1 NR3C1 RPS6KA5 MAP2K2 CREB1 GNAS MAPK3 TOLL-LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20220510%WP3858%HOMO SAPIENS Toll-like receptor signaling related to MyD88 MYD88 CHUK NFKB1 IKBKB RELA MAPK1 IKBKG REL TBK1 IKBKE TLR7 TICAM2 IRAK4 TIRAP TLR1 RELB TICAM1 TRAF6 IRF7 TLR9 IRF3 TLR8 TRAF3 TLR5 TLR4 IRAK1 NFKB2 TLR3 IL-18 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4754%HOMO SAPIENS IL-18 signaling pathway PIK3R1 GPAT4 SPON1 ZDHHC7 CSN2 FAM110A KITLG ZC3H12A LONP2 CCN4 B2M IMP3 ACOD1 ACTA1 LARS2 BIN1 RFX5 DKFZp666K145 AARS1 NRN1 SDC4 TSHZ1 PRKCB MEPCE PLA2G7 TRPM7 ZBTB7A MYH6 ZNF143 NCAPH2 HOXD8 ITM2C TMSB4X PYGB PIGT PHF20 IL18BP IL17RC PTMS ACADS BAZ1B KRT31 hCG_2016482 MMP14 STK40 GRN CXCL3 TOMM40 CENPB TMEM165 RXRB CCL19 CCL18 CA11 IRF6 hEMMPRIN C12orf25 ZNF219 PWWP3A BAT5 CDK5R2 ARF6 RAE1 CD83 CD81 ZNF444 LCK SEMA6C IL2RA VEGFA SEMA6D MAPK3 TF FUT1 HCAR2 NELF CHES1 CNTN2 ULBP2 HSPB8 TNFAIP2 RND2 PPP1R13L NFKBIZ DKFZp564O1822 BPGM TRAF1 ARFGAP2 ARL4D MYH7 RELA RGS16 CCL1 RUNX2 NPPB S1PR4 NPPA UGGT1 ABCF1 MBTPS1 P1 SLC12A3 HEL-S-45 DEK SLC4A7 NOS2 CRYGC BAD SYT10 BMP2 SNTB1 GRIN2B NFKBIA UCK1 CYCS CXCL2 IL10 COL3A1 COL1A2 IL13 IL6 BCL2L1 MMP2 LTB IF2F ATF3 SOCS3 IL12B HEL-S-17 TNIP3 CTNNB1 hCG_16983 TNFSF6 COX17 CASP3 BTG2 IL9 ARG1 IL18 TACR1 NDUFC1 TNFRSF1A MMP3 PARP1 HMOX1 FBXW7 JUN NR0B2 CLDN1 CLDN3 FAS PRKCA PKN1 IL37 CCNB2 CLDN15 DKFZp434N101 CCNA2 PTEN MMP9 IL1B PTGS2 ACTA2 HDAC3 RASA3 CEBPB CCL20 NR1H3 TIMP1 TNF-alpha KLF2 PTX3 CLDN4 IL18RAP TBX21 CD36 TNFSF11 IRF1 PRCC NFKB2 SP1 TNFRSF11B TNFAIP3 COL1A1 UGT2B10 HEL-S-102 LMNB2 ADAMTS5 BIRC3 TIMP3 CCL2 IL18R1 RPS11 BAX CHUK FOS NFKB1 IKBKB MAPK9 SPP1 BCL2 MAPK1 raptor NCF1 NCF2 MAP3K7 TICAM2 TRAF6 ACACB IRAK1 NFATC4 CCL5 CCL4 CCL3 FADD ELAVL1 IL8 MYD88 GSK3B PRKAA1 REL NFKBIE RPS6KB1 tmp_locus_29 ITGA2B CXCL16 KNS2 GATA1 PLATELET-MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20220510%WP4462%HOMO SAPIENS Platelet-mediated interactions with vascular and circulating cells TLR7 CD40 VCAM1 SELE IL1B TGFB1 TLR4 SELP CCL2 CCL5 SELPLG PF4 CD40LG CANCER IMMUNOTHERAPY BY PD-1 BLOCKADE%WIKIPATHWAYS_20220510%WP4585%HOMO SAPIENS Cancer immunotherapy by PD-1 blockade STAT3 PTPN11 NFKB1 JUN NFATC1 CD3D NFATC2 HLA-DRB1 NFATC4 HLA-A LCK NFAT5 NFATC3 CD8B1 CD3G PDCD1LG2 ZAP70 BATF CD8A CD3E IF2F PDCD1 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20220510%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TLR7 STAT3 TGFBR2 CD80 NFKB1 SOCS1 IL2RB IRAK4 IL4 IL2RG TRAF6 CTLA4 TGFB1 TLR8 STAT6 TLR4 NFKB2 CCL2 CCL5 IL2RA PDCD1 CXCL10 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20220510%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing AYP1 ADAR OAS1 IF1DA1 CGAS DDX58 MAVS TREX1 IRF3 MITA IFIH1 RNASEL RNASEH2B RNASEH2A RNASET2 ID SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP53%HOMO SAPIENS ID signaling pathway ID2 PAX5 ELK3 RBL1 PAX8 PAX2 CCNE1 ID1 CDK2 RBL2 MYOD1 ID3 RB1 SOLUBLE ACE2-MEDIATED CELL ENTRY OF SARS-COV-2%WIKIPATHWAYS_20220510%WP5076%HOMO SAPIENS Soluble ACE2-mediated cell entry of SARS-CoV-2 AGTR1 AVPR1B ADAM17 ACE2 ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20220510%WP3943%HOMO SAPIENS Robo4 and VEGF signaling pathways crosstalk RAC1 KDR SLIT2 VEGFA ROBO4 SRC CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20220510%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism XDH NAT2 CYP2A6 CYP1A2 ZINC HOMEOSTASIS%WIKIPATHWAYS_20220510%WP3529%HOMO SAPIENS Zinc homeostasis MT2A SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A2 MT4 SLC39A1 MT3 SLC39A3 SLC39A11 MT1A SLC39A10 MTF1 SLC39A13 MT1F SLC39A12 MT1G MT1B SLC39A14 MT1M SLC30A10 SLC30A7 MT1E SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 SLC30A1 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20220510%WP5130%HOMO SAPIENS Th17 cell differentiation pathway RORA GATA3 STAT3 FOS MAPK14 NFKB1 IKBKB MAPK1 IF2B1 AHR IL23R IRF4 RORC IL-21 RARA TBX21 IL21R IL23A IL17F JAK1 IL17A STAT1 TYK2 JUN TGFB1 IL2 PRKCQ LAT LCK IL2RA CD3G ZAP70 CD3E HIF1A CD247 NFATC1 FOXP3 HLA-DMA STAT6 DKFZp434N101 MTOR NFKBIA PPP3CA PER1 CRY1 IL6R IL1B IL4 CD3D IL6 IL27 NFIL3 SMAD2 TGFBR1 NR1D1 RUNX1 IFNGR1 RXRA IF2F IL27RA SOCS3 MAPK8 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20220510%WP3594%HOMO SAPIENS Circadian rhythm genes RORA DRD3 DRD4 NR1H3 OPN4 OPN3 SFTPC CHRNB2 AHR RORC UBE3A CLDN4 HS3ST2 GNA11 SLC9A3 EP300 MAGEL2 DBP BHLHB2 SIN3A ROCK2 ADORA2A GHRH GHRL DYRK1A CDK4 SIK1 HCRTR2 HCRTR1 KLF10 NR1C1 PBEF1 TYMS PRKDC DKFZp781N011 GNAQ PPP1CC HEL-S-80p NOS2 ID4 CREB1 AVP ID2 EZH2 TOP2A HTR7 TNFRSF11A IL6 HEL112 UBC NFIL3 NR1D1 C1orf51 PRF1 RORB CSNK1E ATF4 CCAR2 PROK2 HNRPD PROK1 KCNH7 USP2 METTL3 SOX14 CSNK1D MAPK8 CARTPT PSPC1 TPH2 TIMELESS TPH1 UTS2 ATF5 DDX5 KMT2A MAGED1 AANAT CREM NPAS2 RAI1 ZFHX3 NONO MAPK9 BTBD9 DDC AHCY CRX NR2F6 SETX FBXL3 TCF2 OGT ADA KDM5A SUV39H2 BHLHE41 HEBP1 RBM4 HEL-S-2 PAX4 SFPQ SERPINE1 THRAP3 ID3 KCNMA1 TH NLGN1 CIPC RBM4B ARNTL2 ATOH7 NPS F7 ARNT2 CRH CAVIN3 PASD1 CRTC1 PER3 SIRT1 MYBBP1A PRKG2 PPARGC1A NOCT EGR1 JUN NCOR1 MC3R JUND PTGDS NGFR SIX3 PML MAPK10 LEP PHLPP1 SKP1 PPARG FAS GSK3B NKX2-1 AgRP NTRK1 PRKAA1 NTRK3 STAR PRKAA2 MTTP ADCY1 HOMER1 PROX1 CHRM1 PTEN NPY2R NR1D2 PER2 PER1 KCND2 CRY2 KLF9 MTNR1A CRY1 MTNR1B RELB SUV39H1 UTS2R GFPT1 HDAC2 HDAC3 HDAC1 DRD1 DRD2 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20220510%WP3965%HOMO SAPIENS Lipid metabolism pathway PLIN1 ACLY PNPLA2 HILPDA AKT3 ABHD5 PRKAA1 PRKAR1B PRKACG PRKAR1A PRKAA2 PRKAB2 ACACA ACSS2 PDHA1 PRKAG1 PRKAG2 PRKAG3 FASN PRKAB1 CLOCK-CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20220510%WP5205%HOMO SAPIENS Clock-controlled autophagy in bone metabolism LRP5 CTF1 NPAS2 WNT10B SP7 WNT16 BCL2 AMBRA1 EFNB2 BHLHE41 BMP4 TNFSF11 SQSTM1 HEL-S-70 BHLHB2 ARHGAP4 FYCO1 LAMP2 TMEM77 TRAF6 SEMA3A CTHRC1 SEMA4D TGFB1 BMP5 BMP3 PLEKHM1 HMGB1 TNFRSF11B LEP ATG3 ATG10 ATG12 MAP1LC3A FLJ10035 RB1CC1 DKFZp762B153 IGF1 PRKAA2 RUNX2 NFATC1 BMP6 SMAD4 C12orf44 SMAD1 SMAD9 DKK1 BMPR2 BMP2 MTOR DKFZp781O1323 ULK1 NR1D2 PER1 CSF1 CRY1 TNFRSF11A ATG5 CTSK IL3 SOST IL6 CALCA RORB NOTCH1 PTH LDLRAD4 AND WHAT WE KNOW ABOUT IT%WIKIPATHWAYS_20220510%WP4904%HOMO SAPIENS LDLRAD4 and what we know about it SMAD2 TGFBR1 TGFBR2 TMEPAI FLJ10035 NEDD4 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20220510%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment CHUK NFKB1 IKBKB NFKBIA RELA MUC1 IL6 TNF-alpha IKBKG EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20220510%WP581%HOMO SAPIENS EPO receptor signaling GRB2 STAT5B STAT3 MAP2K1 SOS1 IRS1 SOCS1 EPO STAT1 PTPRC SRC SHC1 MAPK1 CISH PTPRU MAP2K2 RAF1 EPOR MAPK3 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20220510%WP5049%HOMO SAPIENS Glycolysis in senescence HEL-S-30 HEL-S-133P HEL-S-68p HEL-S-17 PRKAA1 ALDOC HEL-S-162eP RB1 NANOPARTICLE-MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20220510%WP2643%HOMO SAPIENS Nanoparticle-mediated activation of receptor signaling MAP2K1 SOS1 MAPK14 MAPK9 COL1A1 AREG MAPK1 NRAS TLN1 PIK3CD MAPK13 MAPK11 DKFZp686M02159 KRAS GRB2 ITGA1 AKT3 HRAS SRC ITGB1 EGFR MAP2K2 RAF1 PXN MAPK10 MAPK8 DKFZp666O0110 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20220510%WP4564%HOMO SAPIENS Neural crest cell migration during development STAT3 PIK3R5 ARHA FOS PIK3CA ARF1 TRIO CDH11 BDNF F2RL2 PIK3CD EPHB6 TWIST1 EPHB1 EPHB3 RAC1 AKT3 EPHB4 MMP9 TIAM1 JUN EPHB2 PAK1 PAK6 NGFR MMP2 PAK4 PIK3R4 PIK3R3 ANGIOPOIETIN-LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20220510%WP3915%HOMO SAPIENS Angiopoietin-like protein 8 regulatory pathway PIK3R2 PIK3R1 MAP3K12 INS NR1H3 CBLC RPS6KA5 PIK3CD PIK3C2G PIK3C2A ABCG8 ABCG5 RPS6KA4 MAP2K5 CRK FOXO1 RAPGEF1 MAP4K1 MAPK6 MAPK4 MAPK3 CBL MAPK7 RICTOR MAP3K2 MAP4K2 SLC2A4 MAPKAP1 IRS1 HEL-S-31 MINK1 CYP3A4 MAPK8 SCD EIF4EBP1 GYS1 SESN3 MAP2K1 INSR MAPK14 MLXIPL MAPK9 PIK3CA MAP3K11 GSK3A MAPK1 raptor PRKAG1 PRKAG2 PRKAG3 DKFZp686M02159 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 CYP2B6 MLST8 MAP3K8 PCK1 SREBF2 MAP3K7 HRAS MAP2K4 MAP3K5 MAP2K3 PRKAB2 SHC2 SHC3 TSC2 MAP3K6 MAP3K10 TSC1 MAP3K13 FLOT1 FLOT2 MAP2K6 DKFZp686P1551 FASN ANGPTL8 MAPK10 PRKAB1 PTPN1 HEL-S-42 TRIP10 SOS1 SOS2 GSK3B FOXO3A CAP1 SLC16A2 PDPK1 PRKAA1 SLCO1C1 PRKAA2 SHC1 LPL G6PC1 MTOR MAPK13 MAPK11 RPS6KB1 RHEB RPS6KB2 MAP3K1 THRA THRB FBP1 EIF4E CYP7A1 MAP2K2 RAF1 IRS4 RXRA DKFZp686J04131 PIK3R4 PIK3R3 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20220510%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer SLC16A3 PSPH TIGAR ACLY HEL-S-30 DKFZp686O15119 PYCR2 HEL-S-133P PAICS HEL-S-68p PSAT1 HEL-S-17 HEL-S-162eP PDHA1 ACO2 HEL107 GOT2 GLUD1 HK3 PFKL ALDOB HEL-S-51e SDHB FH MDH2 RPIA SUCLG2 FASN PGAM1 MRNA PROCESSING%WIKIPATHWAYS_20220510%WP411%HOMO SAPIENS mRNA processing SUGP2 CELF1 CELF2 SRP54 CELF4 PTBP1 DHX15 DHX16 HNRPA1 RBM5 RBM17 NCBP1 NCBP2 PRPF40A PRPF18 NHP2L1 SNRPA1 DNAJC8 SF3B5 SF3B2 CSTF2T U2AF1 PPM1G PABPN1 U2AF2 SNRPN TRA2B SPOP SNRPB2 SF3B1 SRSF10 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 RBMX PRMT1 SMC1A HNRPD METTL3 NONO SFPQ POLR2A YBX1 DICER1 SNRPD2 SNRPD1 CLP1 PAPOLA HNRNPAB SNRPD3 TXNL4A PSKH1 PRPF4B CDC40 PRPF4 PRPF6 DKFZp686A11192 PRPF3 PRMT2 DKFZp686J2031 SNRPG CD2BP2 SRSF4 SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA SNRPB SRSF9 SF4 TMED10 DHX8 CSTF3 DDX1 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 SRPK2 CPSF4 CPSF1 FUS CPSF3 CPSF2 SUPT5H SFRS3 CLK4 WDR57 SRPK1 CLK2 LSM2 HNRNPL CLK1 DKFZp686A13234 LSM7 RNPS1 HNRNPC CLASRP DKFZp434N041 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20220510%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK14 PRKACG MAPK9 PRKAR1A DAGLA ADCY1 MAPK1 AHR MAPK13 MAPK11 DKFZp686M02159 NAPEPLD DKFZp434A091 DAGLB PRKAR1B CYP2C19 ADORA2A CYP3A4 CNR2 CYP2C9 CNR1 MAPK3 MAPK10 MAPK8 CYP1A1 DOPAMINE METABOLISM%WIKIPATHWAYS_20220510%WP2436%HOMO SAPIENS Dopamine metabolism PPP2CA MAOA PRKACG HEL-S-44 DDC TYR NQO1 TH EICOSANOID SYNTHESIS%WIKIPATHWAYS_20220510%WP167%HOMO SAPIENS Eicosanoid synthesis TBXAS1 PTGES PLA2G5 PLA2G4B IPLA2(GAMMA) ALOX5 PNPLA3 GGTLA4 GGTLC2 PLA2G6 PTGS2 PTGDS ALOX15 ALOX12 LTC4S PLA2G2A PTGS1 PTGIS ALOX5AP ALOX15B TRYPTOPHAN CATABOLISM LEADING TO NAD+ PRODUCTION%WIKIPATHWAYS_20220510%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD+ production TDO2 NMNAT3 NMNAT1 HEL-S-90n NMNAT2 AADAT KYNU PBEF1 HAAO NMRK2 NMRK1 AFMID KMO NAPRT NADSYN1 IDO1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20220510%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders CDKN1A CYP27B1 ENPP1 NFKB1 ROS1 FGF23 KL DMP1 SPP1 CYP11B2 SLC34A3 GALNT3 SLC34A1 FAM20C CCND1 NFKB2 FGFR3 FGFR2 ALPL CYP24A1 PTH NRP1-TRIGGERED SIGNALING PATHWAYS IN PANCREATIC CANCER %WIKIPATHWAYS_20220510%WP5144%HOMO SAPIENS NRP1-triggered signaling pathways in pancreatic cancer CTGF KDR MAP2K1 CCNE2 CDKN1B NFKB1 RELA COL1A1 GSK3A MAPK1 REL SMAD4 PLXNA2 CDK2 FLT1 SNAI1 NRP1 HGF RAC1 TGFBR2 TGFBR3 AKT3 MMP9 COL1A2 SRC SEMA3A RELB SMAD2 TGFB1 TGFBR1 PLXNA4B CCNE1 CHD2 PLXNA1 EGFR MAP2K2 NFKB2 MMP2 MAPK3 VEGFA EGF DKFZp666O0110 SNAI2 MACROPHAGE MARKERS%WIKIPATHWAYS_20220510%WP4146%HOMO SAPIENS Macrophage markers LYZF1 CD74 CD83 CD14 CD163 CD68 F3 MIRNAS INVOLVEMENT IN THE IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20220510%WP4329%HOMO SAPIENS miRNAs involvement in the immune response in sepsis IL8 MYD88 CHUK VCAM1 MAPK14 NFKB1 IKBKB RELA TNF-alpha IKBKG REL NFKBIA TLR7 IRF1 MAP3K7 IL10 IRAK4 IL1A RELB IL6 TRAF6 IRF7 TLR8 TRAF3 TLR4 IRAK1 NFKB2 CCL4 CCL3 ELANE IRF5 LCN2 MAPK8 MAP3K7IP1 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20220510%WP4921%HOMO SAPIENS Mitochondrial complex III assembly CYC1 UQCRQ CYTB UQCR11 UQCR10 UQCRC1 UQCRC2 UQCRB UQCRFS1 UQCC3 UQCC2 UQCRH TTC19 LYRM7 UQCC PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20220510%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway PIK3R2 PIK3R1 STAT3 MAP2K1 CHUK BRAF RAD51 NFKB1 IKBKB MAPK9 PIK3CA PEBP1 MAPK1 IKBKG CCND1 RALBP1 PIK3CD TGFA RAC3 RAC1 JAK1 AKT3 STAT1 TIAM1 CDK6 CDC42 TGFB1 GADD45B PAK1 PAK6 RALA RALB CDK4 MAPK3 VEGFA ARAF PAK4 EGF MAPK10 RB1 dik ARHA RELA CASP9 DDB2 GADD45A BAK1 GADD45G SMAD4 POLK BAD MTOR BRCA2 RPS6KB1 RPS6KB2 KRAS CDKN1A TGFBR2 E2F2 E2F3 SMAD2 TGFBR1 BCL2L1 CDKN2A MAP2K2 EGFR RAF1 MAPK8 ERBB2 PIK3R3 BAX AMP-ACTIVATED PROTEIN KINASE (AMPK) SIGNALING%WIKIPATHWAYS_20220510%WP1403%HOMO SAPIENS AMP-activated protein kinase (AMPK) signaling GYS1 PIK3R2 PIK3R1 INSR PIK3CA raptor PIK3CD PRKAG1 ADRA1B PRKAG2 ADRA1A NR2A1 PRKAG3 PRKAB2 ACACB TSC2 TSC1 CPT1C FASN ELAVL1 PRKAB1 LEP CRTC2 EEF2K STRADA STRADB CAB39 CAMKK1 CAMKK2 SLC2A4 PRKACG PRKAA1 INS-IGF2 SLC2A4RG PRKAA2 CCNB1 ACACA STK11 MTOR CCNA2 RPS6KB1 MEF2B RPS6KB2 CDKN1A PPARGC1B LEPR PLCB1 HMGCR ADIPOR1 ADIPOR2 GYS2 PIK3R3 EIF4EBP1 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20220510%WP4658%HOMO SAPIENS Small cell lung cancer PIK3R2 PIK3R1 CHUK NFKB1 hCG_16983 IKBKB PIK3CA BCL2 IKBKG CDKN2B CCND1 CASP3 PIK3CD ITGA6 TRAF2 AKT3 RXRB TRAF6 CDK6 GADD45B CCNE1 TRAF3 TRAF5 CDK4 RB1 DKFZp666O0110 SKP1 CDKN1C CCNE2 COL4A4 ITGAV NFKBIB CDKN1B COL4A3 RARB COL4A6 TRAF1 COL4A5 APAF1 CKS1B RELA CASP9 DDB2 TRAF4 ITGA2 CKS2 GADD45A FHIT BAK1 RXRG GADD45G POLK NOS2 CDK2 NFKBIA PTEN MAX CYCS CDKN1A LAMC2 LAMB2 LAMA4 LAMC1 E2F2 E2F3 ITGA2B BIRC2 LAMA5 COL4A2 BIRC3 LAMA1 COL4A1 LAMA3 BIRC7 PTGS2 BCL2L1 ITGB1 LAMB3 LAMB4 LAMB1 RXRA MYC PIK3R3 BAX FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20220510%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins FAS CASP10 hCG_16983 ARHGDIB APAF1 TNFSF6 CASP9 ACTA1 MAPKAPK3 BCL2 PRKDC TNF-alpha NFX1 FAF1 CASP6 CASP3 RIPK2 ACTG1 LMNA CYCS HEL-S-102 PS1TP5BP1 MAPKAPK2 PARP1 MAP3K1 LMNB2 MAP3K7 MAP2K4 DFFB DFFA JUN IL1A PAK1 FADD MAPK8 RB1 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20220510%WP1533%HOMO SAPIENS Vitamin B12 metabolism INS INSR NFKB1 RELA APOE MPO TNF-alpha MCEE MAT1A SERPINA3 SERPINE1 HEL-S-44 HBB CUBN SCARB1 PLAT APOA1 MTRR TCN2 TCN1 CBLIF HBA2 MMAB F7 MTR DKFZp727E011 ABCA1 F2 CRP SAA4 LDLR PLG HEL-S-51e IL1B DKFZp564M2422 APOB IL6 CTH ALB SAA1 SAA2 CCL2 NFKB2 CCL5 IF2F INTERLEUKIN-1 INDUCED ACTIVATION OF NF-KB%WIKIPATHWAYS_20220510%WP3656%HOMO SAPIENS Interleukin-1 induced activation of NF-kB UBE2V1 AJUBA SQSTM1 IRAK1 NFKB1 IL1A HEL-S-71 TRAF6 TIFA PRKCZ TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20220510%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells PIK3R2 PIK3R1 MAP2K1 PRKCA MAPK14 MAPK9 PIK3CA MAPK1 RPS6KA5 EIF4A2 EIF4G1 raptor MTOR RPS6KB1 PIM2 RPS6KB2 RPS6KA2 RPS6KA4 RPS6KA1 AKT3 MAP2K5 EIF4B MAP2K4 CSNK2A1 MAP2K3 PIM1 EIF4E RPS6 MAP2K2 EIF4A1 MAPK3 MAP2K6 MAPK10 MAPK8 PIK3R3 EIF4EBP1 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20220510%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence CDKN1A IF1DA1 TDO2 HEL-S-90n AADAT KYNU HAAO AFMID IL1R2 KMO FOXO1 IDO1 TNF-alpha AHR KLF5 EIF2AK1 EIF2AK4 TLR4 IDO2 IF2F AMYOTROPHIC LATERAL SCLEROSIS (ALS)%WIKIPATHWAYS_20220510%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis (ALS) GPX1 MAPK14 NEF3 NEFH APAF1 CASP9 BCL2 TNF-alpha NEFL SLC1A2 DERL1 CASP3 BAD HEL-S-2 HEL-S-44 CCS RAB5A TNFRSF1A RAC1 PPP3CA TOMM40 MAP3K5 PPP3CC BCL2L1 MAP2K2 CASP12 MAP2K6 BAX MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20220510%WP4842%HOMO SAPIENS Mammalian disorder of sexual development FGF4B CTNNB1 DMRT1 FST INSL3 DHH FOXL2 GATA4 PBX1 NR5A1 WT1 SOX8 RSPO1 SRY SOX9 AMH PTGDS WNT4 EMX2 FGFR2 RBFOX2 AMHR2 CBX2 MAPK11 EXTRACELLULAR VESICLE-MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20220510%WP2870%HOMO SAPIENS Extracellular vesicle-mediated signaling in recipient cells TGFBR2 PIK3R5 TGFBR3 APC AXIN1 CTNNB1 HRAS SMAD2 SMAD4 TGFB1 WNT3A TGFBR1 NRAS EGFR DKK4 MTOR RAF1 TSPAN8 CD133 TGFA ERBB2 HGF KRAS INTEGRIN-MEDIATED CELL ADHESION%WIKIPATHWAYS_20220510%WP185%HOMO SAPIENS Integrin-mediated cell adhesion PIK3R2 MAP2K1 BRAF MAPK1 ITGA6 DKFZp686M02159 RAC3 RAC1 ITGA1 RAP1A AKT3 MAP2K5 CAV2 HRAS CRK DOCK1 MAP2K3 ROCK1 RAPGEF1 ROCK2 VAV3 SHC3 CDC42 VAV2 PAK1 PAK6 CSK MAPK6 MAPK4 ARAF MAP2K6 PAK4 ITGB4 MAPK10 DKFZp666O0110 MAPK7 ITGAX SOS1 ITGAV PDPK1 RHO ITGB8 ITGB7 HEL-S-28 ITGA4 ITGA2 SHC1 MYLK2 ITGA7 TLN1 VASP ITGAE MYPN CAV3 CAPN9 CAPN6 CAPN7 GRB2 CAPN5 ITGAM ITGB5 CAPN3 TNS1 GIT2 CAPN11 HEL114 CAPNS1 CAPN10 KIAA0142 ITGB3 ITGA2B ZYX SRC ITGB6 FYN SELENOP ITGB1 MAP2K2 RAF1 PXN MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20220510%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission PIK3R2 PIK3R1 STAT3 ARHA CREM GABRG2 PIK3CA SHC1 BDNF DKFZp434N101 GABRB2 CREB1 PTEN GABRG3 AP2A1 GABRG1 GABRB1 GABRE GABRA2 GABRA5 GABRQ ROCK1 GABRP SLC12A5 GABRA6 GABRA4 AP2A2 GABRA3 NTRK2 NGFR GABRB3 PIK3R3 MEVALONATE PATHWAY%WIKIPATHWAYS_20220510%WP3963%HOMO SAPIENS Mevalonate pathway PMVK ACAT2 MVD FDPS MVK HMGCS1 HMGCR CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20220510%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSG CMA1 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20220510%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 SMARCD1 SMARCD2 SMARCD3 SMO EED PTCH1 SMARCE1 GLI3 SMARCA4 RBBP4 SUZ12 DPF1 EZH2 DPF3 SMARCC1 SMARCC2 CDK6 ACTL6B GLI4 DPF2 ACTL6A CDKN2A CDK4 H3F3A ARID1A ARID1B RB1 BURN WOUND HEALING%WIKIPATHWAYS_20220510%WP5055%HOMO SAPIENS Burn wound healing BRD4 AMBP HEL-S-43 MTRNR2L12 HEL113 SLURP1 TIMP1 CD248 NFKB1 FST NOD1 KLF4 ACTA1 NOD2 BCL2 TNF-alpha FGFR4 CASP3 FGFR3 FGFR2 INHBA HGF TLR7 LIN28A MMP3 IF1DA1 TLR1 TLR9 TLR8 TGFB1 TLR5 TLR4 IF1AB4 S100A6 LY96 TLR3 HMGB1 S100A9 SPARC VEGFA CD3E EGF SNAI2 IL8 KDR CXCR4 MYD88 TNFAIP3 NFKBIZ COL1A1 TNC DCN NFKBIA FBN1 FGFR1 ACHE CXCL1 MMP9 IL15 IL1B COL1A2 CHRFAM7A IL1A IL6 FOXE1 CXCL12 HEXD F13A1 CXCL14 CCL2 seTCTP MMP28 KRT6A MMP2 KRT222 ADAM12 PFN1 PCTK1 FLG TAGLN IL8RB CNN2 SCEL BAX SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20220510%WP4496%HOMO SAPIENS Signal transduction through IL1R MYD88 CHUK IL1R1 MAPK14 NFKB1 IKBKB RELA TNF-alpha ECSIT IFNA1 NFKBIA IRAK3 MAP3K1 IF1DA1 MAP3K7 IL1B MAP2K3 JUN IL1A IL6 TRAF6 IRAK2 TGFB1 IL1RN IRAK1 MAP2K6 DKFZp686J04131 MAPK8 MAP3K7IP1 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20220510%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia MCL1 ZAP70 BCL2 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH-RUSSELL PATHWAYS%WIKIPATHWAYS_20220510%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch-Russell pathways NR1H3 TM7SF2 FADS2 FADS1 MYLIP hCG_2024989 ELOVL4 ELOVL5 NR1H2 ELOVL2 ELOVL3 CH25H SOAT2 ABCG1 GGPS1 ACAT2 ABCA1 FDPS IDI1 SREBF2 MVK HMGCS1 CYP51A1 DHCR24 MSMO1 HMGCR EBP ACSL1 DKFZp686B0215 ACOT2 CYP46A1 PMVK MVD FACL4 DHCR7 LBR SC5DL FDFT1 SOAT1 ACSL3 CYP27A1 FASN SCD DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20220510%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C8 CYP2B6 DKFZp686I24235 CYP2C19 EICOSANOID METABOLISM VIA LIPOOXYGENASES (LOX)%WIKIPATHWAYS_20220510%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases (LOX) PTGR1 HEL-S-298 HPGD ACOX1 NR1C1 EHHADH ACOX2 ALOX5 ACOX3 NR1C2 KPG_011 CYP4A22 CYP4F2 TRPA1 TRPV1 CYP4F12 FPRL1 CYP4A11 ALOX15 ALOX12 LTB4R LTC4S ALOX15B MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20220510%WP129%HOMO SAPIENS Matrix metalloproteinases TIMP1 TNF-alpha TCF20 MMP21 MMP20 MMP24 MMP15 MMP27 MMP26 MMP7 TIMP4 MMP10 MMP11 MMP16 MMP12 MMP23B MMP17 MMP19 MMP3 MMP9 MMP14 TIMP3 hEMMPRIN MMP28 MMP2 MMP25 TGF-BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL-MESENCHYMAL TRANSITION%WIKIPATHWAYS_20220510%WP3859%HOMO SAPIENS TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition CDH6 CDH2 CDH16 HEL113 TNC RUNX2 MAPK1 SMAD2 SMAD4 TGFB1 ID1 MAPK3 SNAI1 SNAI2 OMEGA-3 / OMEGA-6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20220510%WP4723%HOMO SAPIENS Omega-3 / omega-6 fatty acid synthesis ACOX1 PLA2G5 PLA2G4B FADS2 FADS1 ACOX3 ELOVL5 ELOVL2 PLA2G6 ACSL1 ACOT2 FACL4 ACSL3 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN-1%WIKIPATHWAYS_20220510%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN-1 MAVS TLR7 IRF3 TLR8 MR1 TLR3 DDX58 TNFRSF11A IFIH1 IRF7 GAMMA-GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE, INCLUDING DISEASES%WIKIPATHWAYS_20220510%WP4518%HOMO SAPIENS Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases HEL-S-64p C7orf24 OPLAH GCLC GGTLA4 GGTLC2 NUCLEAR RECEPTORS%WIKIPATHWAYS_20220510%WP170%HOMO SAPIENS Nuclear receptors RORA PPARG NR1i2 NR1H3 RARB NR1C1 ESRRA NR1C2 NR2F2 NR1H2 NR2F6 RXRG PGR NR3C1 ESR2 RORC RARA NR2A1 NR2C2 NR1D2 NR2E1 THRA ESRRB NR2F1 THRB NR0B1 NR5A2 RXRB NR5A1 NR1I3 RXRA ROR1 NR1i1 NR1B3 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20220510%WP2853%HOMO SAPIENS Endoderm differentiation TCF7L1 NR3C1 ZIC5 DNMT3B TBX21 SFRP1 NOG LHX1 TCF4 NODAL MIXL1 PIAS1 STAT1 FOXO1 GATA6 VAV3 TGFB1 FOXH1 FOXA2 CHES1 APC ACACA WNT3 BPTF SMAD4 BMPR1A DKK1 SOX2 EZH2 LAMC1 SOX17 CER1 PLCH1 CEBPZ NLK PTHLH CTNNB1 TCF2 FOXA1 SOX21 CEP250 WDHD1 DUSP4 EMSY HPRT1 CRTC1 WDFY2 TOX MBTD1 WWC1 EPB41L5 SFMBT1 UBR5 MAP2K3 CDYL DKFZp686L2367 RFX7 GATA4 PBX3 RAB38 CTR9 GDF3 BCORL1 PRDM14 RTF1 ZFHX4 OTX2 TRERF1 SESN1 SIAH2 EXT1 SP4 TAF4B TRIM71 PAF1 SCHIP1 APP ONECUT1 PHF6 HOXC11 CDC73 TRIM5 HHEX ZIC3 C1QBP Pax9 JARID2 PABPC1 BTAF1 ELAVL1 TET1 CAND1 PARP8 TCEAL2 NR1B3 LEO1 OBFC2B KDM4A TOX3 LRPPRC TNRC6C AEBP2 TAF5 DKFZp586H0919 NKX2-1 AHDC1 ELP4 RGS10 PBX1 CUL4B SOX7 SLC2A12 HOXA1 POU5F1 PAX3 MAD2L2 SMAD2 ATP8B2 NOTCH1 CTBP2 WNT8A DUSP2 PHOTODYNAMIC THERAPY-INDUCED NFE2L2 (NRF2) SURVIVAL SIGNALING%WIKIPATHWAYS_20220510%WP3612%HOMO SAPIENS Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling SRXN1 NQO2 ABCG2 ABCC6 FOS CES1 MAPK14 HMOX1 EPHX1 JUN ABCC3 ABCC2 GCLC KEAP1 MAPK13 MAPK11 NQO1 MAPK8 HEL-S-22 DKFZp686M02159 GCLM NFE2L2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20220510%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 FAS MAP3K1 NFKB1 AIFM1 hCG_16983 APAF1 TNFSF6 CASP9 hCG_20684 CASP6 CASP3 RIPK1 FADD MAPK10 TNFRSF1A CYCS MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20220510%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways ATF1 ACTA1 GNG12 OXT RGS2 PDE4D GNG2 PRKCB MYL2 ARRB2 IGFBP1 ETS2 PRKCZ SLC8A1 CXNK2 IGFBP5 PRKCQ SP1 MAFF ADCY3 ADCY6 ATP2A2 CAMK2D PRKCH CAMK2A ACKR3 RGS16 PRKCE RYR1 RYR2 MYLK2 GNAQ RYR3 PDE4B CAMK2G CACNB3 CREB3 ADCY9 CREB1 GNAS OXTR CALM3 CALM2 PLCG2 IL6 PLCB3 DGKZ ATF4 ATF3 CNN2 ATF5 FOS NFKB1 GNGT1 GNB1 ATF2 ACTG1 PS1TP5BP1 CRH PRKAR1B JUN GNG11 HEL2 GNG13 ATF6B ITPR2 PRKCA RXFP2 RGS4 RGS5 RGS6 RGS7 PRKAR1A IGFBP4 RGS10 IGFBP2 GABPB2 HEL-S-14 ADCY1 CRHR1 ADCY8 GRK5 GABPA GRK4 SFN CALD1 IGFBP6 PKIB PKIA GPR182 YWHAQ RLN1 HEL-S-1 PKIG DKFZp434N101 YWHAG MYL4 ADM YWHAZ RGS18 GNB2 RGS17 GNB4 RAMP2 GNB3 RAMP3 GNB5 RGS14 RGS20 EDG2 CORIN GUCA2B GUCA2A RGS11 RCP9 RAMP1 IL1B CALCA GNG3 HEL-S-21 GNG5 RGS1 GNG4 ACTA2 GNG7 GNG8 PRKD1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway CYP1B1 MAP2K1 CDKN1B NFKB1 RELA CCL1 KLF6 TNF-alpha MAPK1 AHR NRAS CDC37 LPL CDK2 NF1 CD36 EP300 FGF8C KRAS CDKN1A AIP RET DKFZp761B2210 PLAGL1 HRAS NCOR2 SRC AHRR PTGS2 EGFR GCLC RAF1 VEGFA NQO1 CYP1A2 RB1 MYC CYP1A1 NFE2L2 PI3K-AKT-MTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES%WIKIPATHWAYS_20220510%WP3844%HOMO SAPIENS PI3K-AKT-mTOR signaling pathway and therapeutic opportunities PIK3R2 PIK3R1 RICTOR GSK3B CDKN1B RB1CC1 FOXO3A HRAS TFEB PIK3CA FOXO1 NRAS GRB10 TSC2 BAD raptor MTOR ULK1 PTEN RHEB FOXO4 PIK3R3 EIF4EBP1 KRAS NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20220510%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity PPARG CYP27B1 NR1i2 NR1H4 NR1H3 RARB NR1C1 NR1C2 CYP4B1 ABCG1 CYP26A1 RARA ABCC3 ABCB1 ABCC2 ABCD3 ABCB4 CYP4A11 CYP24A1 ABCG5 ABCA1 CYP2B6 ABCD2 CYP3A4 NR1I3 ABCB11 CYP7A1 CYP2C9 CYP2E1 NR1i1 CYP1A2 NR1B3 BIOSYNTHESIS AND TURNOVER OF 1-DEOXY-SPHINGOID BASES%WIKIPATHWAYS_20220510%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1-deoxy-sphingoid bases SPHK2 SPHK1 SGPP2 SGPP1 SPTLC1 SPTLC2 KDSR GABA METABOLISM (AKA GHB)%WIKIPATHWAYS_20220510%WP4157%HOMO SAPIENS GABA metabolism (aka GHB) HEL-S-166mP ALDH5A1 ADHFE1 ABAT PON3 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20220510%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RARB HEL-S-4 ADH1A MAPK1 RXRG HEL-S-53e DKFZp686G1675 CYP26A1 RARA LPL ALDH1A2 RBP1 CD36 DGAT1 SCARB1 ABCG8 ABCG5 CYP26B1 SULT1A1 RETSAT RDH8 CRABP2 RXRB CRABP1 RLBP1 SDR16C5 RDH12 NPC1L1 AWAT2 RDH10 LRAT BCO1 DHRS3 RPE65 RBP7 RXRA RBP4 RBP2 RDH5 CYP2E1 SULT2B1 NR1B3 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20220510%WP5061%HOMO SAPIENS Fatty acid transporters FABP5 FABP6 SLC27A4 DBI FABP1 ACSL1 FACL4 ACSL5 CD36 ACSL3 FABP9 FABP2 FABP4 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2516%HOMO SAPIENS ATM signaling pathway BRCA1 CHEK2 AP3B2 MDC1 RAD51 MDM2 MAPK9 TP53BP1 GADD45A TP73 hCG_20684 CCNB1 IKBKG CHEK1 RAD50 CDK2 ATF2 MRE11A RAD9A H2AX CREB1 ATM NBN NFKBIA SMC1A CDKN1A JUN PIDD1 CRADD CCNE1 MDM4 TLK1 CDC2 FANCD2 RIPK1 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20220510%WP545%HOMO SAPIENS Complement activation C8G C4B_2 CFP C2 C6 C7 C9 CD55 MASP2 ADIB MASP1 ADIC ADIA CFD HEL-S-62p C1S C8A C1R C4A DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20220510%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i2 NR1H4 BAAT SLC51A SLC51B SULT2A1 SLCO1B1 CYP3A4 NR1I3 ABCC3 ABCB11 CYP7A1 ABCC2 ABCB1 NR1i1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20220510%WP4753%HOMO SAPIENS Nucleotide excision repair CETN2 XPA XPC GTF2H2C_2 GTF2H2 GTF2H3 DDB2 GTF2H5 CUL4B CUL4A ERCC3 ERCC1 ERCC5 POLD3 POLD4 POLD2 RPA1 RBX1 ERCC2 POLE RPA3 POLE2 RFC3 MNAT1 RFC4 RFC1 CCNH PCNA LIG1 RFC2 DDB1 POLE4 POLE3 CDK7 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20220510%WP5120%HOMO SAPIENS Inclusion body myositis KIAA1149 PSEN2 PSENEN NFKB2 APP SIRT1 NFKB1 GDF8 PSEN1 NANOMATERIAL-INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20220510%WP3890%HOMO SAPIENS Nanomaterial-induced inflammasome activation PYCARD DKFZp686N0152 TLR4 NFKB1 IL1B CYTOSOLIC DNA-SENSING PATHWAY%WIKIPATHWAYS_20220510%WP4655%HOMO SAPIENS Cytosolic DNA-sensing pathway CHUK NFKB1 hCG_16983 IKBKB IKBKG PYCARD TREX1 CCL4L2 LOC728835 ZBP1 RNF125 IL33 ISG15 CYLD IFNA4 IFNA1 TBK1 IL18 IF1AA3 IKBKE IF1AA1 AIM2 IF1AA6 IFNA13 IF1AA5 IF1DA1 IF1AA4 IFNA14 CGAS DDX58 IF1AA9 IF1AA8 TRIM25 IRF7 MAVS IRF3 DKFZp686D10173 IF1AB4 CCL5 CCL4 IF1AB1 RIPK1 FADD POLR1C POLR1D CXCL10 POLR3GL POLR3A CASP10 POLR3C POLR3D ATG12 POLR3E NFKBIB POLR3F POLR3G RIPK3 POLR3H POLR2F POLR3K POLR2H POLR2K RELA POLR2L NLRX1 MITA NFKBIA TRADD ADAR IL1B ATG5 IL6 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20220510%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer GATA2 ADAM10 CCL1 TNF-alpha BMI1 FCGR3A hCG_2009644 NCR3LG1 TIGIT MICA MICB CD96 NCR1 NCR3 CD226 CSF2 FOXO1 ADAM17 PRF1 CCL2 CCL5 CCL4 CCL3 IF2F MYC LEUKOCYTE-INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20220510%WP4542%HOMO SAPIENS Leukocyte-intrinsic Hippo pathway functions ARHA FOXO3A MAPK14 TAFAZZIN PRDM1 FOXP3 LPL TMEM49 YWHAQ FOXO4 CCR7 RAC1 RAP1A FOXO6 FYB1 KNSTRN TEAD4 MOB1A RAB13 LATS1 FERMT3 LATS2 FOXO1 TEAD2 STK38L TEAD3 CD19 DKFZp451O0517 POLYOL PATHWAY%WIKIPATHWAYS_20220510%WP690%HOMO SAPIENS Polyol pathway AKR1B1 ALDOB SORD COPPER METABOLISM%WIKIPATHWAYS_20220510%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC31A1 SLC11A2 RETT SYNDROME CAUSING GENES%WIKIPATHWAYS_20220510%WP4312%HOMO SAPIENS Rett syndrome causing genes BRAF MEF2C GNAO1 DKFZp686M09200 HTT GRIN2B SMARCA4 STXBP1 TCF4 SMC1A CDKL5 NCOR2 CRK KDM5B TRRAP FOXG1 NCOR1 CHD4 RHOBTB2 ACTL6B GABRA3 CECR2 TAF1B IMPDH TBL1X SMARCA1 HIVEP2 SCN1A HDAC5 GABBR2 EIF2B2 SRRM3 KCNJ10 XAB2 TBL1XR1 SCN8A HDAC1 HAP1 SCN2A SYNGAP1 HDAC8 TGF-BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20220510%WP560%HOMO SAPIENS TGF-beta receptor signaling STAT3 FOS ZNF423 NFKB1 CTNNB1 FST MAPK9 SPP1 WNT1 TNF-alpha ZEB2 NOG EP300 BMP4 SERPINE1 INHBA JAK1 HRAS STAT1 SKI SKIL JUN SMAD6 TGFB1 ZFYVE9 FOXH1 MAPK3 EGF ENG LTBP1 BAMBI DKFZp586H0919 TGIF1 RUNX2 SMAD4 SMAD1 SMAD9 FKBP1A DKFZp781O1323 LEFTY2 LEFTY1 TGFBR2 TGFBR3 THBS1 ITGB6 SMAD2 TGFBR1 LIF RUNX3 CREBBP IF2F ALLOGRAFT REJECTION%WIKIPATHWAYS_20220510%WP2328%HOMO SAPIENS Allograft rejection IL12B IL12A HEL113 hCG_16983 TNFSF6 LRRK2 TNF-alpha IF2B1 IL-21 CASP3 GDNF ABCB1 MICA PRKCZ CXCL9 CD80 IL17A STAT1 CXCL13 CCL19 TGFB1 IL2 HLA-DRB5 IL2RA VEGFA C8A C4A CXCL11 IL8 FAS PECR CXCR5 GNLY HLA-DOA HLA-DOB HLA-DPA1 BHMT2 HLA-DQB1 HLA-DMB HLA-DQA2 HLA-DQA1 HARS1 CCL21 HLA-DPB1 CASP9 GABPA FOXP3 HLA-DMA CD40 C4B_2 C2 IL10 IL13 IL1B C6 IL4 C7 IL1A C9 CTLA4 TUBA1B IL5 CSNK2A2 CD55 HLA-DRA CXCL12 HLA-DRB1 PRF1 ADIB PDGFRA ADIC HLA-B HLA-C AGTR1 ADIA HLA-A HEL-S-62p HLA-F HLA-G IF2F CD40LG HLA-E G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20220510%WP35%HOMO SAPIENS G protein signaling pathways RRAS GNGT1 GNB1 GNG12 PDE4D GNAI3 PRKCI GNA11 PRKCB GNAO1 PRKCZ HRAS PRKAR1B ARHGEF1 GNA13 GNG11 PRKCQ GNG13 GNGT2 hCG_1994888 ADCY3 ADCY6 PRKCA ARHA PRKACG PRKCH PRKAR1A HEL159 PRKCE AKAP12 AKAP10 ADCY1 AKAP11 ADCY8 PDE4A GNAQ PDE8A PRKD3 GNAI1 NRAS PDE4B GNAZ PDE1C PDE1A AKAP8 AKAP7 ADCY9 AKAP6 AKAP4 GNA14 GNAS GNA15 GNB2 KCNJ3 AKAP9 GNAL GNB3 GNB5 PDE7B PDE7A KRAS CALM3 PPP3CA CALM2 AKAP5 GNG3 GNG5 PPP3CC PLCB3 GNG4 GNG7 GNG8 DKFZp686L23131 PRKD1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway ALAS1 SULT2A1 NCOA1 ABCC3 ABCB1 ABCC2 UGT1A1 NCOA6 CYP4A11 CYP2A6 SMC1A DNAJC7 SULT1A1 CYP2B6 EHHADH PPARGC1A CYP2C19 FOXO1 CYP3A4 NR1I3 UGT1A4 PTPA UGT1A3 UGT1A9 CYP2C9 SP1 RXRA GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20220510%WP2276%HOMO SAPIENS Glial cell differentiation GAP43 HEL70 CNP MBP FREP1 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20220510%WP3298%HOMO SAPIENS Melatonin metabolism and effects CYP1B1 GSK3B PRKCA AANAT EDN1 NFKB1 CAMK2A APOE ASMT MAOA ECE1 PER2 CALM3 PER1 CALM2 SULT1A1 PER3 CRY2 ACHE SIRT1 MTNR1A CRY1 MTNR1B CYP2C19 FOXO1 TRAF6 ADRB1 CSNK1E IRAK1 MAP2 CSNK1D CYP1A2 CYP1A1 SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20220510%WP733%HOMO SAPIENS Serotonin receptor 2 and STAT3 signaling STAT3 HTR2A GNAQ FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling pathway IL12B MYD88 CHUK ARHA CD14 NFKB1 IKBKB RELA PIK3CA TNF-alpha IKBKG REL NOS2 PLAT FGA ITGAM IF1DA1 LBP PLG CXCL3 TICAM2 IRAK4 SRC TIRAP TICAM1 HEL-S-78p IL6 TRAF6 IRAK2 SYK IRF3 TLR4 LY96 TYROBP IRAK1 CCL2 TLR3 CXCL10 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20220510%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins SNW1 NEO1 GABRG2 KCNQ2 MAPK9 RAP1GAP CAMK2G KCNJ6 GRIN2B ATP2B1 GRIN1 TERF2IP KCNMA1 PRKCZ GPHN CSN3 CDH2 GRIK2 CHL1 EPB41L3 MAP4 NCDN CLASP1 CAV2 NTNG1 CADM3 CADM1 CASK DAB1 AGRN PLCB4 STX2 GABBR2 MAPK4 EFNA5 GLYCINE METABOLISM%WIKIPATHWAYS_20220510%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e MIR-124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20220510%WP3595%HOMO SAPIENS mir-124 predicted interactions with cell cycle and differentiation STK11 STRADB PTBP1 PRKAA1 CTDSP1 SIX4 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20220510%WP558%HOMO SAPIENS Complement and coagulation cascades SERPINF2 F5 F8 F13B KLKB1 SERPINE1 PLAT BDKRB1 F7 F2 PROC F9 F3 PLG F10 HEL-S-78p PROS1 CLU KNG1 C8G SERPINA1 CR2 CR1 THBD SERPING1 MASP2 MASP1 CD46 CFD CLTC C1S CFH C1R C5AR1 CFI VWF F2R C4B_2 C2 C6 C7 C3AR1 C9 PLAUR CPB2 SERPINC1 CD55 TFPI LMAN1 ADIB ADIC SERPIND1 ADIA HEL-S-62p MIR-517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20220510%WP3596%HOMO SAPIENS miR-517 relationship with ARCN1 and USP1 CDKN1A ID2 ID1 USP1 ARCN1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20220510%WP5050%HOMO SAPIENS TCA cycle in senescence ME1 PDHA1 FH BRAF PDP2 ME2 HEL-S-32 NRF2 PATHWAY%WIKIPATHWAYS_20220510%WP2884%HOMO SAPIENS NRF2 pathway GSTA5 GSTA4 GSTA3 SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A2 SLC39A1 SLC39A3 HGF ALDH3A1 SQSTM1 FTL GSTT2 TGFB1 SLC2A9 GCLC MAFF FGF13 GCLM NFE2L2 HSP90AB1 SRXN1 SLC2A2 SLC2A3 SLC2A4 SLC2A6 NR1C2 SLC2A7 SLC2A8 ME1 ABCC3 GPX2 ABCC2 ABCC5 UGT1A1 GPX3 CYP4A11 HEL-S-25 CYP2A6 NRG1 HEL-S-22 TGFBR2 CES2 CES1 UGT2B7 SLC5A12 SLC5A10 DNAJB1 UGT1A4 UGT1A3 UGT1A9 hCG_1991559 KEAP1 UGT1A7 FTH1 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A8 SLC5A9 CES8 CES3 EPHA3 EPHA2 HEL-S-10 MGST3 MGST2 TGFA TXN SLC5A1 ADH7 SLC6A20 SLC5A2 SLC5A4 SLC5A5 HMOX1 GGTLA4 EGR1 GSTM3 GSTM2 GSTM1 HEL-S-128m SLC6A5 SLC6A7 SLC6A8 SLC6A9 GSTM5 SERPINA1 SLC7A11 SLC6A1 SLC6A2 SLC6A3 GGTLC2 SLC2A14 SLC2A11 SLC2A10 SLC2A13 SLC2A12 SLC39A11 SLC39A10 SLC39A13 SLC39A12 PTGR1 SLC39A14 HEL-75 HBEGF RXRA NQO1 NEUROINFLAMMATION%WIKIPATHWAYS_20220510%WP4919%HOMO SAPIENS Neuroinflammation CHUK COX2 FOS MAPK14 RELA JUN TLR4 NOS2 MTOR ASCC1 NFKBIA MAPK8 COX1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20220510%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta LRP5 IFITM5 CRTAP P3H2 P3H1 P4HA1 P4HA2 P4HB PPIB MBTPS2 COL1A1 SP7 WNT1 MBTPS1 FZD1 LRP6 TNFSF11 TNFRSF11A COL1A2 BMP1 MIA3 PLOD2 TNFRSF11B PLOD1 ADAMTS2 TMEM38B COLGALT1 LOX TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20220510%WP1584%HOMO SAPIENS Type II diabetes mellitus PIK3R5 IRS1 SLC2A2 INSR SLC2A4 INS-IGF2 DKFZp686J1568 CACNA1A IKBKB PHKA2 TNF-alpha MAPK1 MAFA PDX1 MTOR SURF1 MAPK8 PRKCZ DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20220510%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport MTHFD1 MTR FTCD FOLR1 HCP1 HEL-S-70p DHFR HEL-S-51e MTHFS TYMS PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20220510%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM3 RAC1 CTF1 STAT3 PPP3CA CALM2 ARHA FOS MAPK14 EDN1 CAMK2D MAP2K3 MYEF2 PRKCE GATA4 JUN MAPK1 IL6ST PRKCB NFATC4 MAPK11 MAPK8 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20220510%WP500%HOMO SAPIENS Glycogen synthesis and degradation GYS1 PPP2CA PPP2R1B PYGL GYG1 GSK3B PHKA2 PYGM AGL GSK3A PHKG2 PHKA1 PHKB PYGB CALM3 CALM2 HK2 HK3 PPP2R5E PPP2R5B PPP2R5A PPP2R5C PPP2R2A PTPA PPP2R1A PPP2R3B PPP2R3A PPP2R2C PPP2R2B PPP2R5D GYS2 BILE ACIDS SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20220510%WP4389%HOMO SAPIENS Bile acids synthesis and enterohepatic circulation FXR1 SLC10A2 ABCB11 FGFR4 CYP7A1 LDLR MAPK3 FGF8A ABCG8 ABCG5 MAPK1 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20220510%WP4707%HOMO SAPIENS Aspirin and miRNAs MVD PTGS2 NR1C1 NFKB1 VEGFA WNT1 PTGS1 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20220510%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20220510%WP3601%HOMO SAPIENS Lipid particles composition LPL LDLR APOA2 APOE APOC3 APOA1 APOB EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20220510%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR3D POLR3E TAF5 POLR3H POLR2F POLR3K POLR2H POLR2K GTF2H2C_2 GTF2H2 HEL-S-28 GTF2H3 ERCC3 GTF2B TAF9 GTF2E1 GTF2E2 TBP TAF12 TAF13 GTF2F2 TAF7 TAF6 ERCC2 MNAT1 POLR2A DKFZp686D10173 POLR2B POLR2C CCNH POLR2G POLR2I POLR2J POLR1A POLR1D CDK7 T-CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP69%HOMO SAPIENS T-cell receptor signaling pathway PIK3R2 PIK3R1 GATA3 MAP2K1 CHUK HEL113 PTPN11 FOS MAPK14 NFKB1 IKBKB MAPK9 SH2B3 MAPK1 CRKL IKBKG IRF4 ATF2 RIPK2 IL9 HEL-S-81p PSTPIP1 ICOS TNFRSF9 CCR5 OPRM1 FYB1 MAP3K8 VAV1 IL17A MAP3K7 HRAS CRK MAP4K1 WAS JUN VAV3 TRAF6 GAB2 CDC42 TGFB1 PAK1 ITK CD83 PRKCQ LAT LCK CD3G ZAP70 MAPK3 CD8A CD3E CBL FAS CD247 PTK2B SOS1 PDPK1 RELA SHC1 NFATC1 NFATC2 REL DKFZp434N101 CREB1 NFKBIA GRB2 IL1B FLJ00120 CD3D IL1A IL6 GRAP2 FYN LCP2 MAP2K2 BCL10 NCK1 RAF1 DKFZp686J04131 MAPK8 IL15RA HYPOXIA-MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20220510%WP2943%HOMO SAPIENS Hypoxia-mediated EMT and stemness DICER1 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20220510%WP4217%HOMO SAPIENS Ebola virus infection in host PIK3R2 PIK3R1 TFAP2A DKFZp686N0152 EIF2AK2 EP300 PIK3CD ITGA6 TBK1 IKBKE RAC1 ITGA1 IGF1R CAV2 STAT1 DDX58 MERTK HAVCR2 NPC1 IRF3 CDC42 VAV2 PAK1 NFKB2 HLA-DRB5 MAPK3 HLA-DOA HLA-DOB ARHA HLA-DPA1 HLA-DQB1 HLA-DQA2 HLA-DMB NEDD4 HLA-DQA1 RELA HLA-DPB1 ITGA4 RAB7A ITGA2 HLA-DMA ACTN4 RAB5A CAV3 FLNA FLNB IL4 HLA-DRA HLA-DRB1 ITGB1 RASA2 HLA-B HLA-C HLA-A HLA-F HLA-G HLA-E SOCS3 hCG_2043376 EIF2S1 NFKB1 PIK3CA MAPK1 ACTG1 CTSL CLEC10A ICAM2 PS1TP5BP1 ICAM3 VPS39 VPS18 CD300A VPS33A TIMD4 TSG101 SCIN VPS11 TIAM1 VPS16 ADAM17 BST2 CD209 CLEC6A ASGR1 IRF7 HAVCR1 HLA-DQB2 VPS4A TLR4 DAB2IP PRKRA RFC1 VPS41 FOLR1 RAB9A C1QBP ITGAV MBL2 REL TYRO3 CLTCL1 GAS6 CLTC CLTB CLTA ITGB3 RELB RHOB hCG_1991735 EGFR ACTN1 CREBBP AXL NPC2 PIK3R3 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20220510%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 COHESIN COMPLEX - CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20220510%WP5117%HOMO SAPIENS Cohesin complex - Cornelia de Lange syndrome ESCO1 PPP2CA PPP2R1B ESCO2 REC8 MAU2 STAG3 APC PLK1 RAD21 SMC1B SMC1A ESPL1 PPP2R5E PPP2R5B PPP2R5A PPP2R5C DKFZp686I05169 CDC2 PTPA PPP2R1A SMC3 CDCA5 PDS5B PDS5A AURKB NIPBL PTTG1 PPP2R5D SGOL1 HDAC8 WAPAL NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP61%HOMO SAPIENS Notch signaling pathway PIK3R2 SKP1 PIK3R1 GATA3 STAT3 SNW1 PSEN2 DLL3 GSK3B DLL4 MAML2 FHL1 ITCH DTX1 NFKB1 MAGEA1 CIR1 SPEN HES5 JAG2 CCND1 SAP30 EP300 HEY1 RBPJ CDKN1A HEY2 DKFZp762E1511 FBXW7 APH1B NCOR2 MAML1 SRC ADAM17 NCOR1 NUMB HES6 DKFZp434N181 PSENEN HES1 NOTCH3 NOTCH1 HDAC2 LCK PSEN1 HDAC1 HIF1A MYC CILIARY LANDSCAPE%WIKIPATHWAYS_20220510%WP4352%HOMO SAPIENS Ciliary landscape RAB3IL1 ARFGAP3 DKFZp762K123 RABEP2 NME8 EXOC4 FLJ22688 NEF3 RAB2 EFHC2 EXOC5 MAPRE2 EXOC1 PAFAH1B1 WDR26 TFAP2A SSNA1 TFAP2B USH1C RAB21 RMND5B IFT74 DNPEP PGRMC2 RMND5A GID4 MFAP1 BBS4 ECHS1 RAB14 TTC30B VAPB SNRPB2 TTC30A GID8 RQCD1 DYNLT1 AGPAT2 YPEL5 DYNLT3 GLA HSPB11 RAC1 C11orf60 DYNC2I2 DYNLRB2 RABL5 DKFZp727E011 TRAF3IP1 IFT172 IFT80 LZTFL1 IFT81 RALB LCN2 RB1 INTU UQCC HEL-S-296 COPS5 HEL-S-47e APC NEK8 CAMK2A BBS2 BBS1 DYNC1H1 NEFL BBIP1 DYNLL2 DYNC1LI1 MKS1 IFT27 PSMD12 DNCL1 HEL-S-91n IFT52 EXOC8 PSMD13 CALM3 EXOC2 UBE2D2 CALM2 BBS9 BBS7 PSMD7 IFT57 BBS5 CEP290 IQCB1 DCAF7 IFT140 STOM DKFZp451O0517 MSH2 H3F3A PSMC6 PSMC4 DDX5 HEL113 CCDC40 NFKB1 ANKS3 CTNNB1 DYNLT2B hCG_2028821 COPS6 TTC8 XPNPEP3 CLUAP1 NDUFA9 VPS4A NDUFA5 EXOSC4 ACSL3 DKFZp686P1551 COX6C LRPPRC DGKE TBC1D4 RANBP9 SMC4 MAEA APMAP CEP97 ARMC8 MYL6 TIPRL ERF MCM7 DKFZp686J2031 ARL8B POM121 CD2BP2 COPS7A IQGAP3 DKFZp781J211 CDH23 CDR2 AAR2 CTSA UBE2H TFAP2C DKFZp586M1622 TFAP2D TFAP2E MCM5 RHBDD2 MCM6 EXOC6B MCM2 HTRA2 CNOT10 LSM4 COPS4 IFT20 EHD3 WNK1 CNOT1 RANBP10 COPS8 TTC26 WEE1 GDI1 ZMYND19 MCM9 MCM10 MYL6B hCG_1991735 RPGR TNKS1BP1 CEP170 TMED1 DFNB31 NINL CREBBP SNAP29 EXOC6 HDAC2 RAB8A CTBP2 EIF5B RBM14 NUDC HDAC1 CNOT6L NUP133 EIPR1 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20220510%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL ACAT1 MODEL FOR REGULATION OF MSMP EXPRESSION IN CANCER CELLS AND ITS PROANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20220510%WP4397%HOMO SAPIENS Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors CTCF MSMP CCR2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20220510%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB APOBEC3G TCEB1 CUL5 RUNX1 RBX1 UBB SEROTONIN AND ANXIETY-RELATED EVENTS%WIKIPATHWAYS_20220510%WP3944%HOMO SAPIENS Serotonin and anxiety-related events PPP3CA CRH 5HT1A FOS PRKCB PLCD4 HTR2A ARC NLGN1 PLEK CRHR1 PEPTIDE GPCRS%WIKIPATHWAYS_20220510%WP24%HOMO SAPIENS Peptide GPCRs GALR2 GALR1 CCR10 NTSR1 NTSR2 FY CCR1 NMBR MC1R BRS3 MC4R CCKAR BDKRB2 TACR3 CCR8 BDKRB1 TACR1 CCR7 CCR6 NPY5R ATP8A1 CCR5 CCR4 TACR2 CCR3 OPRM1 CXCR6 CCR2 TAC4 SSTR2 SSTR3 AVPR1B SSTR4 SSTR5 AVPR1A MC3R CCKBR CX3CR1 FSHR NPY4R OPRD1 CXCR5 CXCR4 OPRK1 CXCR1 HCRTR2 HCRTR1 CXCR3 AVPR2 MC5R TSHR NPY2R OXTR C5AR1 GHSR GRPR LHCGR NPY1R EDNRA EDNRB C3AR1 GNRHR FPRL1 FPRL2 TRHR AGTR1 AGTR2 FPR1 IL8RB MC2R GALR3 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20220510%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MAP2K1 BRAF FOS CTNNB1 TCF7L1 MAPK9 CSNK1A1L BCL2 MAPK1 CCND1 BBC3 CASP3 TBK1 RAC3 RAC1 APC2 AKT3 DCC MSH3 JUN TGFB1 GADD45B RALA CSNK1A1 RALB PMAIP1 MAPK3 ARAF MAPK10 NTN1 GSK3B ARHA DKFZp586H0919 APC MSH6 AXIN1 AXIN2 CASP9 DDB2 GADD45A BAK1 TCF7L2 REL GADD45G SMAD4 APPL1 POLK BAD BCL2L11 CYCS KRAS CDKN1A EXOC2 TGFBR2 SMAD2 TGFBR1 PTGS2 MSH2 RAF1 BIRC5 MAPK8 MYC BAX HAIR FOLLICLE DEVELOPMENT: CYTODIFFERENTIATION - PART 3 OF 3%WIKIPATHWAYS_20220510%WP2840%HOMO SAPIENS Hair follicle development: cytodifferentiation - part 3 of 3 GATA3 WIF1 PERP FOS NFKB1 KITLG CTNNB1 FOSB TCF3 FST EGR2 MSX1 NR3C1 FZD1 SFRP1 BMP4 TCF4 HR IGFBP5 Nbla10317 HOXC12 KRTAP3-3 ADAM17 PHLDA1 JUN TP63 KRTAP15-1 SPINK6 SPINK5 DKK3 TGFB1 SOX9 ADAMTS20 DSG1 GAS1 S100A4 DSG4 GPRC5D GPR49 DLX3 ATL1 ELANE KLK5 FOXQ1 KLK4 GTPBP4 LRIG1 KRTAP6-1 GJB6 KRTAP2-4 GSDMA CTGF KLK6 ZBTB16 KLK13 KLK14 FOXN1 KRT19 DKFZp586H0919 IGF1 KRTAP8-1 NFATC1 BMP6 SMAD4 SMAD1 BMPR1A DKK1 DSC2 CD133 RBPJ CD200 SOX2 CASP14 MSX2 SOSTDC1 CD34 FOXE1 DKFZp434N181 DKK4 EGFR NOTCH1 RUNX3 IF2F PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20220510%WP4224%HOMO SAPIENS Purine metabolism and related disorders HPRT1 XDH ADSL PAICS AMPD1 PFAS hCG_40733 APRT HEL-S-156an ADSS AOX1 TPMT ADA IMPDH HEL-S-70p RRM2B HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20220510%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HAMP ID1 TMPRSS6 HFE HFE2 BMP6 CYTOSINE METHYLATION%WIKIPATHWAYS_20220510%WP3585%HOMO SAPIENS Cytosine methylation TET3 TET2 IDH1 TET1 MBD3 TDG GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20220510%WP4815%HOMO SAPIENS Glycosaminoglycan degradation GALNS HGSNAT HPSE2 IDUA HYAL2 HEXB HEXA HYAL4 DKFZp686E12166 HPSE GUSB SGSH TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS-COV-2 INFECTION%WIKIPATHWAYS_20220510%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS-CoV-2 infection MYD88 EIF2AK2 IFIH1 TBK1 IKBKE OAS2 TMPRSS2 TREML4 JAK1 OAS3 TLR7 IFNAR2 OAS1 STAT1 DDX58 STAT2 IRAK4 TYK2 TRAF6 ACE2 IRF7 MAVS TLR9 IRF3 TRAF3 TLR4 IRF9 TLR3 IFNAR1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20220510%WP3947%HOMO SAPIENS Serotonin and anxiety PPP3CA CRH FOS ARC PLEK POMC TRPV1 5HT1A PRKCB PLCD4 HTR2A FMR1 ADRA1A MONOAMINE GPCRS%WIKIPATHWAYS_20220510%WP58%HOMO SAPIENS Monoamine GPCRs DRD3 DRD4 DRD5 HTR1E HTR1F HTR1D HTR1B 5HT1A CHRM2 HTR2B CHRM3 ADRA1D CHRM1 HTR2A ADRA1B ADRA1A CHRM4 CHRM5 HTR4 ADRA2C HTR6 ADRA2B HTR7 ADRA2A ADRB3 ADRB1 ADRB2 HRH1 HRH2 DRD1 DRD2 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20220510%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHA SDHB HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20220510%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway IRF6 ARHA ARHGAP29 WNT1 TFAP2A TP63 FBXL10 ENHANCEMENT OF MAP/ERK SIGNALING IN DIFFUSE LARGE B-CELL LYMPHOMA%WIKIPATHWAYS_20220510%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma SUZ12 EZH2 H3C8 H2AZ2 H2AFY2 H2AB3 H2AB1 MACROH2A1 RNF2 H3C15 H2AFJ MAPK1 PCGF1 BCL6 EED H2AZ1 BCOR H2AX MAPK3 H3F3A NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20220510%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification ITGA1 DLL3 DLL4 SOX6 GJA5 JAG2 MGP CALU FGFR3 NOTCH1 ALPL VEGFA PLAT EDG2 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20220510%WP5171%HOMO SAPIENS Leukotriene metabolic pathway ABCC1 PTGR1 DPEP2 DECR2 DECR1 ALOX5 GGTLA4 GGTLC2 LTC4S ALOX5AP CYP4F3 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20220510%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 TGFB1 STAT3 NFKB1 RASGRF1 MYEF2 16P11.2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20220510%WP4950%HOMO SAPIENS 16p11.2 distal deletion syndrome KDR RABEP2 SDCCAG8 SH2B1 INSR CR2 TRAF1 RAB4A NFATC2 DKFZp779O2152 IFITM1 NFATC2IP TRAF2 RAB5A GRB2 PRMT1 IL4 CD19 VAV2 CD82 LAT CD81 PLN SLN SPIN1 HEL-S-62p TUFM ATXN2L MPL WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20220510%WP4150%HOMO SAPIENS Wnt signaling in kidney disease LRP5 ARHA DVL1 WNT10B CTNNB1 DVL2 MAPK9 WNT5B WNT1 WNT16 WNT3 FZD3 WNT3A WNT11 WNT10A FZD1 FZD2 WNT2B FZD5 FZD4 FZD7 FZD9 WNT9B FZD8 INVS LRP6 DKFZp586M1622 WNT7B WNT7A WNT4 MAPK10 MAPK8 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20220510%WP408%HOMO SAPIENS Oxidative stress response NOX5 GPX1 JUNB FOS MAPK14 NFKB1 MAOA GPX3 MGST1 HEL-S-44 XDH HMOX1 HEL-75 GSTT2 DKFZp564M2422 CYBB UGT1A3 GCLC SP1 NFIX NQO1 MAPK10 TXN2 TXNRD2 CYP1A1 NOX3 NFE2L2 PEROXISOMAL BETA-OXIDATION OF TETRACOSANOYL-COA%WIKIPATHWAYS_20220510%WP1941%HOMO SAPIENS Peroxisomal beta-oxidation of tetracosanoyl-CoA ACOX1 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20220510%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R15A PPP1R13B PPP1R11 HEL-S-89n PPP1R10 MAP1LC3A XBP1 PPP1R3A PPP1R9A PPP1R9B EIF2S1 PPP1R2 MBTPS2 PPP1R7 PPP1R8 PPP1R16B PPP1R14A PPP1R14B PPP1R1B BCL2 PPP1R16A MBTPS1 PPP1R3G PPP1R3F PPP1CC PPP1R1A DDIT3 HEL-S-80p EIF2AK1 PPP1R3B PPP1R1C PPP1R3E EIF2AK2 PPP1R3D PPP1R14D PPP1R3C PPP1R12B PPP1R12C ERN1 ATF4 PPP1R14C MAPK8 DKFZp781H1925 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP363%HOMO SAPIENS Wnt signaling pathway LRP5 PPARG GSK3B RYK PRKCA ARHA DKFZp586H0919 APC DVL1 AXIN1 CTNNB1 TCF3 DVL2 AXIN2 MAPK9 GSK3A MAPK1 NFATC2 TCF7L2 CCND1 SOX1 PRKCB GCKR ARRB2 MTOR BCL9 CSNK1G1 STM7 LRP6 TCF4 DKFZp586M1622 RAC1 FRAT1 CXNK2 MAP3K7 CDK6 CSNK1E TSC2 CSNK1A1 TSC1 ROR1 ROR2 PI4K2A CTBP1 MAPK8 CSNK1D NLK MYC MALE INFERTILITY%WIKIPATHWAYS_20220510%WP4673%HOMO SAPIENS Male infertility GPX1 CYP17A1 XPC PEMT MGRH TNF-alpha AHR HEL-S-61p ERCC1 EP300 GNAO1 MTRR TCN2 MTR HEL110 SRD5A2 CHD2 NFE2L2 DND1 MDM2 ESR2 P1 H3-4 NOS2 FOLH1B XRCC3 FOLH1 ERCC2 THBS1 HLA-DRA UBE2B MMP2 DKFZp686J1569 HIST1H4J INSR TNFSF6 BCL2 ABCB1 CCNK PRDM9 SIRPG EPSTI1 SLC16A7 RAG1 NANOS1 FAT10 PRM2 DKFZp666C074 MTHFD1 PARP1 SPATA17 MSH4 HCP1 MSH5 SIRPA TSSK6 SHMT1 TSSK4 DDX4 DAZ3 VCX DKFZp564M2422 STRA8 APOB MOV10L1 H2BW1 TMEM132E XRCC5 TAS2R38 PUM2 DAZL PIWIL2 CRISP2 RFC1 PIWIL1 PIWIL4 SPO11 HORMAD2 POLG MSMB CLU HMGA1 PRMT6 PACRG CYP1A1 ETV5 CXXC1 OR2W3 FAS USP26 PEX10 REC8 CDC42BPA MLH3 CTCFL PSAT1 SEMG1 KDM3A TRIP13 BRDT AGO2 ATM BRCA2 CYP26B1 PON2 PON1 SOX5 MMP9 AHRR CREBBP NQO1 CDK9 HISTONE MODIFICATIONS%WIKIPATHWAYS_20220510%WP2369%HOMO SAPIENS Histone modifications HIST1H4J AEBP2 KMT2A KMT2C SETD4 KMT2E SETD5 SETD3 SET SETD8 SETD9 SMYD5 EHMT1 SETD6 KMT2B EED SUV39H2 DOT1L MLL2 PRDM2 SMYD2 SMYD4 SMYD3 H4C7 SETDB1 KMT5C SETD1B SETD1A SETDB2 SETD2 SETMAR ASH1L SETBP1 EZH1 EZH2 H3C8 H3C15 DKFZp313O0925 SUV39H1 SETD7 H3F3A MITOCHONDRIAL IMMUNE RESPONSE TO SARS-COV-2%WIKIPATHWAYS_20220510%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS-CoV-2 NFKB1 TOMM70 NLRX1 ACAD9 ECSIT MITA NDUFAF1 IFIH1 TBK1 CTSL IKBKE TMPRSS2 TLR7 PHB2 NDUFB9 CGAS DDX58 TICAM1 TRAF6 ACE2 IRF7 MAVS IRF3 TRAF3 NFKB2 TLR3 AGTR1 AGTR2 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20220510%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CDKN1A EDG5 PRKCA S1PR5 SPHK1 RPP38 MGC26963 SGPP1 S1PR1 DEGS1 PLCB1 MAPK1 CERS2 CDK2 PRKCB TERT MTOR CDK4 UGCG SPTLC1 RB1 KDSR MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20220510%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HES1 HIF1AN VEGFB HEY1 VEGFC VEGFA HIF1A HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP4249%HOMO SAPIENS Hedgehog signaling pathway PRKACG CSNK1A1L SMO BCL2 CCND1 PTCH1 GLI3 CCND2 EVC2 ARRB2 CSNK1G1 SPOP SUFU HHIP IHH KIF3A ADRBK1 DHH BOC CDON CSNK1G3 PTCH2 FBXL17 SPOPL CSNK1G2 KIF7 CSNK1E GAS1 SHH GPR161 CSNK1A1 EVC CSNK1D SMURF2 SMURF1 IL6 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP364%HOMO SAPIENS IL6 signaling pathway PIK3R2 PIK3R1 STAT3 MAP2K1 SOS1 GSK3B JUNB PTPN11 TIMP1 PRDM1 NR2F6 SHC1 MAPK1 IL6ST NCOA1 BAD RPS6KB1 RAC1 JAK1 GRB2 IRF1 CRP VAV1 MAP3K7 STAT1 IL6R MAP2K4 TYK2 IL6 BCL2L1 MAP2K2 CREBBP MAPK3 VIP HDAC1 SOCS3 NLK MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP382%HOMO SAPIENS MAPK signaling pathway pk RRAS CD14 FGF23 FGF22 CRKL GNG12 RPS6KA5 FGF1B FGF1A FGFR4 MEF2C FGFR3 FGFR2 RAC3 RAC1 RAP1A RRAS2 RPS6KA4 FGF7B MAP2K5 FGF7A CRK MAP4K1 FGF6B FGF6A DKFZp686K0257 CDC42 PAK1 MAPK3 EGF FGF5C MAPK7 FGF5B FGF5A DKFZp686G14213 MAP3K2 RELA CACNA2D1 CACNA2D3 CACNA2D2 CACNA2D4 CACNB1 CACNB3 CACNB4 CACNA1D CACNA1F CACNG6 CACNG7 CACNG8 CACNA1S CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 PLA2G4B IL1R2 IL1A ATF4 MAPK8 MYC NLK TNFSF6 LRRK2 MAP3K11 CASP3 TRAF2 TNFRSF1A DUSP4 JUN JUND MAP3K6 MAP3K13 ARAF FAS NTF5 PRKCA FGF8A BDNF ECSIT NF1 PPP3CA DUSP3 CACNA1B CACNA1A IL1B MKNK1 PPP3R1 NTRK2 EGFR NFATC3 PTPN5 DUSP2 LAMTOR3 MAP3K12 IL1R1 TNF-alpha DDIT3 ARRB2 CACNA1G STK4 RASGRP4 RASGRP3 DKFZp781H1715 PLA2G4F PLA2G4D TGFB1 PLA2G4E PLA2G4C NFKB2 FGF13 MAP4K2 PRKACG GADD45A NFATC1 TAOK2 MAX HEL-S-102 MAPKAPK2 TGFBR2 MAPKAPK5 FLNA FLNB DUSP10 HEL-S-31 RASA2 MAP2K1 CACNA1C CHUK BRAF FOS MAPK14 NFKB1 IKBKB MAPK9 MAPK1 IKBKG ATF2 FGF8C DKFZp686M02159 RPS6KA3 AKT3 MAP3K8 HRAS MAP3K7 MAP2K4 MAP3K5 MAP2K3 TRAF6 RASGRF1 MAP2K6 MAPK10 MAP3K7IP1 NGF NTF3 SOS1 SOS2 NTRK1 MAPKAPK3 NRAS MAPK13 MAPK11 HEL-S-72p KRAS GRB2 FGFR1 MAP3K1 FGF4B FGF4A PPP3R2 FGF2 FGF4C RELB FGF8 MAPK8IP2 PPP3CC TGFBR1 MAPK8IP3 MAPK8IP1 PPP5C DUSP8 MAP2K2 DUSP9 DUSP7 RAPGEF2 TAOK3 RAF1 TAOK1 HSPA1B DKFZp686J04131 CACNA1I HSPA2 PDGFA DUSP16 PPM1B PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20220510%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE3B ADCY6 PDE6C PDE6A PDE6H PDE6G PDE10A PDE12 GUCY1B1 PDE5A PDE9A ADCY1 PPP1R1B ADCY8 HEL-S-7a PDE4A PDE8A PDE4B PDE4D PDE1C PDE6D GUCY1A2 PDE1A PDE2A ADCY9 GRIN2B CREB1 GRIN1 PDE3A PDE7B PDE7A PDE11A CHRFAM7A ADORA2A DKFZp686L23131 ADCY3 DRD1 DRD2 IL-10 ANTI-INFLAMMATORY SIGNALING PATHWAY %WIKIPATHWAYS_20220510%WP4495%HOMO SAPIENS IL-10 anti-inflammatory signaling pathway JAK1 STAT3 IL10RB HMOX1 HEL-S-10 IL10 STAT1 STAT2 IL10RA IL1A IL6 PHOTODYNAMIC THERAPY-INDUCED HIF-1 SURVIVAL SIGNALING%WIKIPATHWAYS_20220510%WP3614%HOMO SAPIENS Photodynamic therapy-induced HIF-1 survival signaling ANGPT2 HEL-S-30 ANGPT1 HEL-S-133P SLC2A3 HEL-S-68p EDN1 EGLN1 BNIP3L IGFBP2 BAK1 PDHA1 NOS2 SERPINE1 TGFA IGFBP1 HIF1AN PFKL EPO MCL1 PTGS2 BCL2L1 BNIP3 PMAIP1 VEGFA BIRC5 BCL2A1 HIF1A BAX FATTY ACID BETA-OXIDATION%WIKIPATHWAYS_20220510%WP143%HOMO SAPIENS Fatty acid beta-oxidation hCG_16873 HEL-S-49 ACADVL ACADL GPD2 CPT2 ACADM CRAT HADHB LIPC ACSS2 LPL SLC25A20 ECHS1 GCDH LIPF ACAT1 PNPLA2 ACADS ACSL1 FACL4 ACSL5 DECR1 ACSL3 DLD EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20220510%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects CXCL12 PRL ERBB4 RGS16 TNF-alpha KLF2 MYB HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20220510%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease CTGF TGFBR2 ANGPT2 TGFBR3 MAPK14 FLNA RUNX2 SHC1 MAPK1 FBN2 SMAD2 FBN3 SMAD4 TGFBR1 POSTN LTBP2 AGTR1 SERPINE1 MAPK3 MAPK8 NR2C2 FBN1 ENG LTBP1 PPAR-ALPHA PATHWAY%WIKIPATHWAYS_20220510%WP2878%HOMO SAPIENS PPAR-alpha pathway APOA5 NR1H3 DBI KLK15 NR1C1 FABP1 EHHADH SLC27A1 CPT2 ACADM PLTP CCND1 CYP7A1 CDC2 CDK4 UGT1A9 CYP4A11 RXRA APOA2 APOA1 APOC3 MYC ANGIOGENESIS%WIKIPATHWAYS_20220510%WP1539%HOMO SAPIENS Angiogenesis KDR ANGPT1 MAPK14 MMP9 FGF2 PIK3CA SRC MAPK1 TIMP3 SMAD1 PDGFRA FGFR2 DKFZp434N101 CREBBP FLT1 VEGFA DKFZp666O0110 HIF1A PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP2876%HOMO SAPIENS Pregnane X receptor pathway NR1i2 DNAJC7 CYP2B6 SULT2A1 PPARGC1A CYP2C19 SRC FOXO1 SLCO1B1 CYP3A4 NCOA1 CYP3A7 ABCC3 CYP4F12 UGT1A4 ABCC2 ABCB1 UGT1A1 UGT1A3 CYP2C9 SRPX2 UGT1A9 RXRA CYP2A6 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20220510%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS1 PPOX ALAS2 UROD UROS HMBS CPOX DKFZp686P18130 CORTICOTROPIN-RELEASING HORMONE SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2355%HOMO SAPIENS Corticotropin-releasing hormone signaling pathway MAP2K1 JUNB BRAF SULT2A1 FOS FOSL1 MAPK14 NFKB1 CTNNB1 FOSB MAPK9 GNB1 BCL2 MAPK1 TFAP2A CRHBP PRKCI GNA11 CASP3 KRT1 PRKCB IVL CRHR2 GNAO1 ARRB2 KRT14 TRIM28 IL18 TCF4 PARP1 CRH CXNK2 MAP3K5 FLJ23306 POMC JUND TGFB1 TLR4 IL2 PRKCQ SP1 MAPK3 DKFZp666O0110 IL8 GSK3B PRKCA ARHA CYP11A1 CAMK2A RELA HSD3B1 CASP9 PRKAA2 JUP STAR CYP21A2 CRHR1 ACACA GNAQ GNAI1 GNAZ DKFZp434N101 CREB1 GNAS NFKBIA GNB2 GNB3 GNB5 ECE1 HSD3B2 PLCG2 ERN1 RAF1 CASP12 MAPK8 OVARIAN INFERTILITY%WIKIPATHWAYS_20220510%WP34%HOMO SAPIENS Ovarian infertility CDKN1B PRLR PGR ESR2 TBP CCND2 DKFZp686M09200 ATM GJA4 FIGLA DMC1 ZP3 INHA ZP2 LHCGR MSH5 EGR1 NR5A1 NCOR1 DAZL FSHR CDK4 GDF9 NR1i1 CEBPB SMPD1 PTGER2 HIPPO-MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20220510%WP4541%HOMO SAPIENS Hippo-Merlin signaling dysregulation CTNNA1 INSR CTNNB1 TAFAZZIN PPP1R14A CUL4A CDH11 CCND1 FGFR4 EPHA2 FGFR3 YY1AP1 FGFR2 CSF1R FLT1 ITGA6 CD44 RBX1 KIT CDH9 LIN28B CDH8 AMOT CDH16 DCAF1 ITGA1 CDH4 CDH10 CDH12 IGF1R CDH15 TEAD4 CDH17 HRAS PRKAR1B CDH18 LATS1 VGLL4 LATS2 CDH19 CDH24 TEAD2 TEAD3 AJUBA PAK1 PAK6 NGFR PAK4 ITGB4 DKFZp666O0110 CXCL10 CTGF KDR ITGAX ITGAV NTRK1 PRKACG ITGB8 ITGB7 PRKAR1A ITGA4 ITGA2 FOXM1 PPP1CC NRAS HEL-S-80p ITGA7 ITGAE FLT3 KRAS CDH6 CDH2 FGFR1 ITGAM ITGB5 ITGB3 ITGA2B FLT4 ITGB6 NF2 PLCB4 ITGB1 NTRK2 PDGFRA EGFR DDB1 MYC SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20220510%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1B1 MSRB2 MSRB3 CYP1A2 ACQUIRED PARTIAL LIPODYSTROPHY / BARRAQUER-SIMONS SYNDROME%WIKIPATHWAYS_20220510%WP5104%HOMO SAPIENS Acquired partial lipodystrophy / Barraquer-Simons syndrome CFD LMNB2 HEL-S-62p FNTA RCE1 LMNA MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20220510%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome MBP UBE3A MEF2C HEL-S-20 TAP1 IGF2 CTCF FKBP5 IGF1R FGF7A SIN3A PSIP1 NCOR1 FOXG1 HNRPF RBFOX1 POU3F2 GPRIN1 RPS6 DLX6 NREP GRIA3 FUT8 GRIA4 PRPF38A POU4F1 SMC3 SP3 SP1 TARDBP TAF1 YBX1 SGK1 TET1 FGF5C OPRK1 CAMK2A IGF1 TET3 BCL6 TET2 BDNF NF1 CREB1 MTOR GRIN1 SST PTEN EZH2 MYT1 CNP FGF2 CDON FUS GAD1 DLX5 HDAC1 REST CEBPD TGF-BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20220510%WP4816%HOMO SAPIENS TGF-beta receptor signaling in skeletal dysplasias STAT3 FOS ZNF423 NFKB1 CTNNB1 FST MAPK9 SPP1 WNT1 TNF-alpha ZEB2 NOG EP300 BMP4 SERPINE1 INHBA JAK1 HRAS STAT1 SKI SKIL JUN SMAD6 TGFB1 ZFYVE9 FOXH1 MAPK3 ADAMTSL2 pp6425 EGF ENG LTBP1 BAMBI DKFZp586H0919 TGIF1 RUNX2 SMAD4 SMAD1 SMAD9 FKBP1A DKFZp781O1323 LEFTY2 LEFTY1 FBN1 TGFBR2 TGFBR3 THBS1 ITGB6 SMAD2 TGFBR1 LIF RUNX3 CREBBP IF2F ADIPOGENESIS%WIKIPATHWAYS_20220510%WP236%HOMO SAPIENS Adipogenesis RORA BSCL2 GATA3 CELF1 STAT3 LPIN3 GATA2 INS NR1H3 DVL1 WNT10B EGR2 WNT1 LPIN1 KLF15 LPIN2 TNF-alpha AHR KLF5 NR3C1 DDIT3 RARA FZD1 MEF2C BMP4 TWIST1 AGPAT2 MIXL1 SOCS1 NDN STAT1 PNPLA3 FOXC2 STAT2 FOXO1 HNF1A TGFB1 SP1 MBNL1 RB1 GTF3A HIF1A ADFP TRIB3 WWTR1 ASIP RETN MEF2D SPOCK1 GDF10 KLF7 NR1C1 C10orf70 SLC2A4 PBEF1 WNT5B IGF1 NR1C2 GADD45A KLF6 IL6ST RXRG STAT6 BMP2 CREB1 MEF2B CDKN1A IRS1 IL6 LIF SFRP4 BMP1 SOCS3 SCD PTGIS STAT5B CTNNB1 MIF SERPINE1 ID3 NR2F1 PCK1 PPARGC1A GATA4 NCOR1 GADD45B BMP3 PCK2 HMGA1 LEP PPARG FAS PLIN1 OSM FRZB UCP1 PRLR NCOA1 CYP26A1 LPL GH1 CFD ZMPSTE24 RBL2 LMNA CYP26B1 NCOR2 E2F4 RBL1 CNTFR IRS4 RXRA CEBPA CEBPB CEBPD JOUBERT SYNDROME%WIKIPATHWAYS_20220510%WP4656%HOMO SAPIENS Joubert syndrome PDE6A PDE6G CETN2 ZNF423 DVL1 HTATIP ARL13B TMEM67 PDE6D PCM1 BBS4 PARP1 TTC8 CEP41 B9D2 RPGRIP1L TMEM138 CEP104 ARL3 INPP5E ARHA NPHP1 NPHP3 CCP110 PIBF1 ARR3 ARMC9 NEK8 hCG_23373 BBS2 MYO6 PCNT BBS1 RAB3IP CEP97 CPLANE1 TMEM231 TMEM17 RAD50 TMEM237 MKS1 MRE11A UNC119 MTOR ATM INVS CEP164 RHEB DKFZp586M1622 AHI-1 TCTN3 SUFU TCTN2 TCTN1 FLNA BBS9 BBS7 BBS5 CC2D2A CEP290 OFD1 ATF4 SHH RAB8A RP2 TMEM216 KALLMANN SYNDROME%WIKIPATHWAYS_20220510%WP5074%HOMO SAPIENS Kallmann syndrome ASCL1 GRB2 FGFR1 PTPN11 PIK3CA OLIG2 PLXND1 SOX10 FGF8 MAPK1 MYRF SEMA3E TMEM98 OTX2 ANOS1 GNRH1 MAP2K2 PROK2 PRKCQ FRS2 NEUROG1 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT (BASED ON CRISPR)%WIKIPATHWAYS_20220510%WP4536%HOMO SAPIENS Genes related to primary cilium development (based on CRISPR) FLJ22688 DYNLT2B ARL13B RAB23 TMEM67 IFT74 KIAA0753 EVC2 BBS4 TTC30B hCG_2028821 SCLT1 DYNLT1 HSPB11 C11orf60 DYNC2I2 TTC8 TRAF3IP1 IFT172 CEP19 CLUAP1 IFT80 RPGRIP1L LZTFL1 IFT81 WDPCP CEP104 ARL6 ARL3 DYNC2LI1 INPP5E PIBF1 ARMC9 BBS2 BBS1 DYNC2H1 CEP97 CPLANE1 TMEM231 TMEM17 TTC23 CBY1 EFCAB7 MKS1 CDK20 IFT27 TRAPPC11 KIFAP3 CEP295 CEP20 C2CD3 TEDC1 DNCL1 TEDC2 FBF1 KATNB1 IFT52 TUBD1 KIF3B TCTN3 DKFZp686L0872 CEP76 TCTN2 RABL2B TMEM107 TUBE1 TCTN1 CPLANE2 MIB1 IFT20 BBS9 SASS6 BBS7 KIF3A CEP162 IFT57 CIBAR1 BBS5 CEP44 CC2D2A TTC26 OFD1 IFT140 WDR35 BBS10 EVC BBS12 TMEM216 KIAA1569 CCDC41 ALPHA 6 BETA 4 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling pathway PIK3R2 PIK3R1 SOS1 PRKCA PTPN11 ARHA MAPK14 SHC1 MAPK1 MTOR ITGA6 LAMC2 RAC1 GRB2 IRS1 LAMB2 LAMC1 HRAS LAMA5 LAMA1 SRC LAMA3 LAMB3 LAMB1 MAPK3 ITGB4 DKFZp666O0110 EIF4EBP1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20220510%WP2855%HOMO SAPIENS Dopaminergic neurogenesis ASCL1 STAT3 CDKN1C GBX2 SLC6A3 NKX2-2 DDC MSX1 WNT1 HEL-S-53e TH SOX2 RET NEUROD1 NKX6-1 PITX3 FGF8 EN2 EN1 LMX1A OTX2 TGFB1 LMX1B SHH SLC18A2 FOXA2 NEUROG2 SMALL LIGAND GPCRS%WIKIPATHWAYS_20220510%WP247%HOMO SAPIENS Small ligand GPCRs PTGER3 PTGIR EDG5 MTNR1A S1PR1 MTNR1B S1PR4 GPR50 PTGDR S1PR3 CNR2 PTGER4 PTGFR CNR1 PTGER1 TBXA2R PTGER2 EDG2 EXTRAFOLLICULAR B CELL ACTIVATION BY SARS-COV-2%WIKIPATHWAYS_20220510%WP5218%HOMO SAPIENS Extrafollicular B cell activation by SARS-CoV-2 IL12A EBI2 XBP1 PRDM1 TNF-alpha IRF4 IL-21 TNFSF13 ZEB2 TBX21 ISG15 IFITM1 BCR ICOS CCR7 TLR7 IFNAR2 CD80 TNLG7A CRP PTPRC IFIT2 FOXO1 CCL19 SYK CD19 TLR4 IL2 PDCD1 C4A CXCR5 ITGAX CXCR4 CR2 CR1 CCL21 BCL6 MAF HEL-S-72p CD40 PAX5 IL10 IL4 IL6 CXCL12 BACH2 BLNK AID CD82 TMSB10 MS4A1 IRF8 EBI3 CD1D HEL-S-62p CD79A SLAMF7 IF2F CD40LG SELL CD69 CD22 VEGFA-VEGFR2 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP3888%HOMO SAPIENS VEGFA-VEGFR2 signaling pathway PIK3R2 PIK3R1 XB HEL-S-15 GPX1 HLX S1PR1 BIN1 RPS6KA5 GRB10 PRKCI MEF2C PRKCB HGS MYL2 SH2D2A TMSB4X FOXO4 PRKCZ TRAF3IP2 RAC1 AMOT RAP1A CXNK2 TEAD4 MMP14 F3 CRK SYNJ1 ROCK1 BMP10 ROCK2 NUMB hEMMPRIN CDC42 EPN1 VAV2 PAK1 CSK ARF6 WASF1 VEGFA SEMA6D MAPK3 FUT1 CBL PTPN6 LIMK1 ENG DKFZp666O0110 PTK2B RICTOR ARHA DKFZp564O1822 ITCH RAB4A MDM2 ACKR3 RELA PRKCE MYO6 CACNA2D1 TRPC1 ACACA DKK1 HEL107 BMP2 NFKBIA PSMD11 CYCS ITGB5 PLA2G5 PSMD4 TNFRSF25 PLAUR ERN1 BCL2L1 LMAN1 ITGB1 ATF4 TNFRSF10C TMSB10 NCK1 MMP2 BIRC5 MAPK8 LUC7L UBAP2L CHAC1 ATP6V1E1 hCG_2043376 IER5 EIF2A PTPN11 TMEM170A HEL-S-133P P4HA2 SND1 HEL-S-68p P4HB INPP4B EWSR1 CTNNB1 HEL-S-162eP KATNAL2 TXNIP ATP6V0D1 FLII GIGYF2 FXR2 DHX36 PRRC2C MICAL2 LARP7 TFAM TRIP4 MOV10 EPHA2 HYOU1 DHX29 FARSB ARF4 KCNC3 HBD EPRS1 SHB ANXA1 EEA1 TXN SH3BGRL3 CLIC1 FGA CGNL1 SSR4 SSR3 DKFZp781J074 VPS39 FJX1 KANK1 NEXN CRIP2 HEL-S-99n SLC7A1 APOLD1 FGD5 DKFZp564M2422 EGR1 GPC1 COPG1 JUN FHOD1 HEL-S-78p CTNND1 tal-1 hCG_1811539 ALB TMOD3 ARMCX1 RAB37 PRKRA NCL PTMAP7 HEL-S-128m HEL2 ERG ZNF555 DSC1 LRRC59 LOC115098 HTRA1 SDCBP MYH11 PTPN1 DKFZp781H1925 ZC3H15 HEL-S-94n FAS SDF2L1 HEL-S-84 TBCA BMX PRKCA RCAN1 TFCP2 SPIRE1 TPP1 GRSF1 C15orf39 FHL2 NRARP DKFZp686J1169 LDB2 SHC1 RND1 CAPZB LRRFIP2 FAF1 ADAMTS9 ARHGEF15 SLC2A14 DKFZp686A11192 TRPC3 SARS1 EIF3S3 MMRN2 EIF4G1 MYH9 DKFZp434N101 SLC25A11 DNAJB4 FAM120A DNAJB9 CLTC ABCF2 SLC25A25 PDE4DIP CDC42BPB AP2A1 FMNL3 MYO1C PPP3CA PTPN9 EIF3F EIF3D NAPA MKNK1 HBEGF AP2S1 FYN PTGS2 EIF4E SRPK1 HDAC4 HDAC5 CREBBP HDAC1 STAT3 HDAC9 GATA2 HDAC7 SRP54 CTNNA1 DLL4 ADAM10 CYR61 NR4A3 CCND1 TCEB1 DOK1 PRKD2 PPM1G ARRB2 GLUD1 SLC8A1 HEL-S-2a HEL164 ACOT9 ELOA STAT1 AFDN RAPGEF1 FOXO1 CYBB HMGB1 CTGF KDR HEL-S-87p CAMKK2 SELE KL HEL-S-156an NFATC1 NFATC2 CCT7 STAT6 RAB11A MAPKAP1 CREB1 TAOK2 RAB5A HEL-S-102 MAPKAPK2 RPL5 MAPKAPK5 FLNB RPL10A SRC RPL7 OCRL CALU PLCB3 DECR1 CCL2 RPL18A RPLP2 RPS11 BRD4 MAP2K1 MAPK14 NFKB1 MAPK9 RPL13A PIK3CA BCL2 MAPK1 RPL27 RPL26 ATF2 FLT1 MMP10 ACTG1 DKFZp686M02159 NCF1 MLST8 NCF2 HRAS MAP2K4 PRKG1 MAP3K5 MAP2K3 DPM1 SHC2 ACACB SIAH2 RPS6 FRS2 CSRP2 FADD PABPC1 MAP2K6 AKT1S1 IL8 PPP2CA ITGAV GSK3B FOXO3A PDPK1 PRKAA1 PRKAA2 SET TMOD1 QK3 MTOR RPS6KB1 GRB2 CCRL2 CYP2C8 ADAM9 AAG1 HEL114 CNP ITGB3 TUBA1C EPHB2 hCG_1991735 ADRB2 MAP2K2 RAF1 IGFBP7 PFN1 PRKD1 EZR TUBB8 PXN NEPHROTIC SYNDROME%WIKIPATHWAYS_20220510%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A4 HEL-S-47e COL4A3 COL4A5 CYP11B2 PAX2 ACTN4 PLCE1 MYH9 ZMPSTE24 CUBN LMNA COQ6 LAMB2 SCARB2 SMARCAL1 CD151 PTPRO E2F3 GPC5 APOL1 SYNPO YARS MST160 ALG1 TRPC6 CTLA4 WDR73 WT1 ARHGAP24 CD2AP MYO1E LMX1B INF2 NPHS1 NPHS2 ADCK4 ITGB4 PHOTODYNAMIC THERAPY-INDUCED AP-1 SURVIVAL SIGNALING%WIKIPATHWAYS_20220510%WP3611%HOMO SAPIENS Photodynamic therapy-induced AP-1 survival signaling FGF5B FAS JUNB FOS MAPK14 TNFSF6 BAK1 BCL2 TNF-alpha CCND1 ATF2 BCL2L11 MAPK13 CCNA2 MAPK11 TRAF2 DKFZp686M02159 TNFRSF1A CDKN1A TNFSF10 MAP2K4 MAP3K5 MAP2K3 JUN IL6 TRAF6 HBEGF BMF MCL1 CCNE1 TRAF5 BCL2L1 PDGFRA CDKN2A IL2 EGFR MMP2 MAP2K6 IF2F MAPK8 RB1 BAX NFE2L2 WNT/BETA-CATENIN SIGNALING PATHWAY IN LEUKEMIA%WIKIPATHWAYS_20220510%WP3658%HOMO SAPIENS Wnt/beta-catenin signaling pathway in leukemia ZBTB16 LRP5 SALL4 WIF1 GSK3B DKFZp586H0919 APC CTNNB1 TCF3 AXIN2 NR1C2 JUP WNT1 RUNX1T1 CCND1 RARA DKK1 PYGO1 CSNK1A1 BCL9 PML LRP6 FLT3 MYC GPCRS, CLASS C METABOTROPIC GLUTAMATE, PHEROMONE%WIKIPATHWAYS_20220510%WP501%HOMO SAPIENS GPCRs, class C metabotropic glutamate, pheromone GRM8 GABBR2 GPRC5D GRM3 GRM2 GABBR1 CASR GPRC5A GRM4 GRM6 GPRC5C ARYLAMINE METABOLISM%WIKIPATHWAYS_20220510%WP694%HOMO SAPIENS Arylamine metabolism SULT1A1 UGT1A4 NAT2 UGT1A9 SULT1A2 CYP1A2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20220510%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells RRAS2 BRAF RRAS HRAS MAPK1 NRAS HGS RAF1 RAB5B MAPK3 RAB5C ARAF RAB5A RAB27A PDCD6IP KRAS MAMMARY GLAND DEVELOPMENT PATHWAY - PUBERTY (STAGE 2 OF 4)%WIKIPATHWAYS_20220510%WP2814%HOMO SAPIENS Mammary gland development pathway - Puberty (Stage 2 of 4) CCND1 HEL113 FOSL1 TIMP1 EGF AREG MYC ERBB2 PGR EFFECT OF PROGERIN ON GENES INVOLVED IN HUTCHINSON-GILFORD PROGERIA SYNDROME%WIKIPATHWAYS_20220510%WP4320%HOMO SAPIENS Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome HEL25 CBX1 MBD2 CHD3 MTA2 DKFZp586H0919 H3C8 MTA3 H3C15 CHD4 MBD3 SUV39H1 HDAC2 KDM1A RBBP7 CBX3 H3F3A HDAC1 RB1 RBBP4 DEGRADATION PATHWAY OF SPHINGOLIPIDS, INCLUDING DISEASES%WIKIPATHWAYS_20220510%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids, including diseases NEU2 NEU3 NEU4 HEXB GM2A HEXA NEU1 GLA VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20220510%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3CA MED14 CHUK MAP3K1 MAPK14 NFKB1 IKBKB RELA MAP2K3 NFATC1 TNF-alpha IL6 IKBKG NR3C1 PPP3R1 SMAD4 NFKBIA RXRA MAP2K6 NR1i1 ONCOSTATIN M SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2374%HOMO SAPIENS Oncostatin M signaling pathway PIK3R1 STAT5B STAT3 MAP2K1 JUNB PTPN11 FOS MAPK14 NFKB1 CYR61 MAPK9 MAPK1 CASP3 PRKCB SERPINE1 JAK1 MMP3 HRAS LDLR STAT1 JAK3 EGR1 TYK2 JUND RPS6 OSMR MAPK3 VEGFA HIF1A PTK2B SOS1 RICTOR OSM CDKN1B PRKCA PRKCH RELA PRKCE SHC1 IL6ST CDK2 CREB1 MTOR NFKBIA KRAS GRB2 IRS1 SRC TIMP3 MAP2K2 CCL2 RAF1 PXN SOCS3 MAPK8 CEBPB PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20220510%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection HCLS1 PRKCA ARHA CD14 TUBA2 CTNNB1 TUBA8 ARPC4 HEL-68 KRT18 TUBAL3 ARPC5 ARPC2 ARPC3 ARHGEF2 YWHAQ YWHAZ WASL ACTG1 PS1TP5BP1 ROCK1 NCK2 ROCK2 ARPC1B WAS TUBA1C TUBA1B TUBA1A CDC42 FYN TLR5 ITGB1 TUBB TLR4 LY96 TUBB2A NCL TUBA3E NCK1 TUBB4B TUBB4A CLDN1 TUBB8 EZR TUBB6 TUBB1 TUBA4A ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20220510%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway CTGF TGFBR2 PTPN11 RRAS COL1A1 COL1A2 MGRA hCG_2011440 MAPK1 IL6ST ACE2 JUND IL11 SMAD4 TGFB1 TGFBR1 PDGFD ACTA2 AGTR1 SP1 RAF1 MAP2K6 HIF1A SUDDEN INFANT DEATH SYNDROME (SIDS) SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20220510%WP706%HOMO SAPIENS Sudden infant death syndrome (SIDS) susceptibility pathways RORA ASCL1 GATA3 SLC25A4 HDAC9 GATA2 CHRNB2 HES5 TNF-alpha VIPR2 NR3C1 PKNOX1 TSPYL1 ADCYAP1R1 DEAF1 MEF2C SLC9A3 SCN3B PHOX2B SCN5A POU2F2 EP300 PHOX2A FEV HTR2A CC2D1A SNTA1 NKX3-1 NOS1AP SCN4B KCNJ8 NFYA CHRNB4 CTCF GPD1L CXNK2 SSTR2 BHLHB2 POU3F2 NFKB2 SP3 SP1 VEGFA TF SPTBN1 AQP4 HIF1A HEL-S-87p RYR2 ESR2 HADHB MAOA CREB1 GRIN1 SST AVP CAV3 VAMP2 SOX2 FREP1 TLX3 ECE1 IL10 IL6R IL13 NEUROD1 IL1A IL6 EN1 LMX1B HES1 REST TPH2 TPH1 HSPD1 CREM PAH ChAT NFKB1 TCF3 CTNNB1 HEL-S-162eP DDC TP73 CASP3 TH TACR1 PRKAR1B PPARGC1A HEL-S-125m EGR1 JUN IL1RN HEL2 YBX1 DLX2 NGF C4A IL8 PRKAR1A NKX2-2 PBX1 FOXM1 ACADM BDNF G6PC1 5HT1A YWHAQ CHRM2 HEL-S-1 YWHAG YWHAZ GNB3 PPARGC1B C4B_2 RET POU5F1 GCK SNAP25 THRB SLC1A3 IL1B CHRFAM7A MYB NTRK2 RUNX3 CREBBP HDAC1 MAP2 CEBPB ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20220510%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis HSD17B6 CYP17A1 CYP11A1 SRD5A2 HSD3B2 HSD17B3 STAR AKR1C2 POR AKR1C4 CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP3929%HOMO SAPIENS Chemokine signaling pathway PIK3R2 PIK3R1 STAT3 PIK3R5 CRKL GNG12 GNAI3 GNG2 PRKCB PIK3CD ARRB2 PRKCZ RAC1 PREX1 RAP1A ELMO1 XCL1 DOCK2 CXCR6 VAV1 PRKX CCL15-CCL14 CCL7 STAT1 CXCL3 CRK CCL17 CXCL13 JAK3 CCL25 CXCL5 ROCK1 CCL24 STAT2 ROCK2 CCL22 WAS CCL28 VAV3 CCL19 CCL26 CCL11 CDC42 LYN CX3CR1 VAV2 PAK1 ITK CSK PPBP MAPK3 PF4 ADCY3 DKFZp666O0110 PTK2B ADCY6 PRKACG CCL21 RELA CCL1 GNAI1 ADCY9 NFKBIA WASL c-fgr PLCB3 PLCB4 CXCL14 IL8RB STAT5B MAP2K1 CHUK CCR10 BRAF CCR1 NFKB1 GNGT1 XCR1 IKBKB PIK3CA GNB1 MAPK1 IKBKG CCR8 CCR7 CCR6 CXCL9 NCF1 CCR4 AKT3 CCR3 CCR2 HRAS TIAM1 SHC4 SHC2 SHC3 GNG11 GNG13 CCL5 CCL4 GNGT2 CCL3 hCG_1994888 CXCL10 CX3CL1 CCL27 CXCL11 CXCR5 SOS1 CXCR4 NFKBIB SOS2 GSK3B FOXO3A CXCR3 SHC1 ADCY1 PARD3 ADCY8 GRK5 PLCB2 GRK4 NRAS GNB2 GNB4 GNB3 GNB5 KRAS GRB2 ADRBK1 PLCB1 GNG3 CXCL16 GNG5 GNG4 CXCL12 GNG7 GNG8 RAF1 PXN PIK3R3 CCL20 IL-2 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP49%HOMO SAPIENS IL-2 signaling pathway PIK3R1 PTK2B STAT5B STAT3 MAP2K1 SOS1 PTPN11 FOS FOXO3A SHC1 BCL2 IL2RG MAPK1 CRKL CCND2 RPS6KB1 RPS6KB2 JAK1 GRB2 HRAS STAT1 JAK3 IL2RB JUN GAB2 NMI FYN SYK RPS6 CISH IL2 MAP2K2 LCK IL2RA RAF1 MAPK3 CBL SOCS3 MYC 7Q11.23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP4932%HOMO SAPIENS 7q11.23 copy number variation syndrome BRD4 STX1A HEL-S-15 EIF2A CTNNB1 HEL-S-162eP MLXIPL hCG_39985 UBE2L6 ATP5G1 HEL-S-271 CLDN4 ATP8 DKFZp566E044 ATP6 ATP5MC2 HEL-S-123m FZD9 SF3B1 ATP5F1D ATP5F1E ATP5PO SQSTM1 BAZ1B MYBBP1A TSG101 PRKG1 LOC93343 ABHD11 ACACB BCL7B BUD23 GTF2I ATPAF2 VPS9D1 PKLR UBE2E3 OGDH UBE2E1 VPS37C PCNA CLDN1 VPS37D BTK DLD MAPK3 VPS37A VPS37B HMGA1 GRIP1 LAT2 LIMK1 DKFZp781H1925 RB1 CLIP2 CLDN5 METTL27 CLDN3 VPS28 FAS FKBP6 CDKN1C ATPAF1 hCG_18987 TRIM50 UBIAD1 DDX21 FBLN5 EIF4H DKFZp586A1519 CLASP2 hCG_19665 SMARCA5 TMEM270 USF1 ACACA GTF2IRD1 DEK H2AX CLTC ULK1 NRG1 VAMP2 FBN1 HOXC8 MYO1C GRB2 SNAP25 CHTF18 CLASP1 ATF4 HDAC2 HDAC3 RFC2 HSPA2 MYC COMPLEMENT SYSTEM%WIKIPATHWAYS_20220510%WP2806%HOMO SAPIENS Complement system F11 SPP1 SFTPA2 KLKB1 CPN1 PTX3 GNAI3 SELP ARRB2 FCGR3A TXN FGA ICAM2 CRP HEL-S-99n PLG F10 WAS IBSP HEL-S-78p ALB CD19 FCN1 FCN2 PROS1 CSNK1A1 ELANE C4BPA C1QBP C8A C4A ITGAX PRKCA MBL2 CR2 CR1 SELE ITGA2 VSIG4 CD93 SERPING1 HEL-S-92n MASP2 FCER2 MASP1 CD46 FKBP2 PRNP CFHR2 DCN CFHR4 ADM CFD SELPLG GNA15 APOA1 C1S CFH C1R C5AR1 CD40 CFI LAMC1 CFP C2 THBS1 VTN ITGB3 ITGA2B LAMA5 C6 C7 C3AR1 C9 CD59 PLAUR C5AR2 CD55 F13A1 LAMB1 RPS19 HEL-S-62p FPR1 SELL COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20220510%WP2636%HOMO SAPIENS Common pathways underlying drug addiction DRD4 MAP2K1 PRKCA PRKACG CAMK2A GRIA2 ADCY1 ADCY8 MAPK1 GNAI1 PPP1CC PPP1R1A HEL-S-80p PRKCB ACTG2 CXNG CREB1 GRIN1 GNAS ACTG1 CALM3 PS1TP5BP1 CALM2 RAP1A GRIA3 GRIA4 MAP2K2 CAMK4 RAF1 MAPK3 ARAF DRD1 DRD2 PCSK9-MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20220510%WP2846%HOMO SAPIENS PCSK9-mediated LDL receptor degradation LDLR PCSK9 SMC1/SMC3 ROLE IN DNA DAMAGE - CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20220510%WP5118%HOMO SAPIENS SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome BRCA1 RAD50 MDC1 PAXIP1 MRE11A ATM SMC3 RAD18 NBN RAD21 SMC1A NOVEL INTRACELLULAR COMPONENTS OF RIG-I-LIKE RECEPTOR (RLR) PATHWAY%WIKIPATHWAYS_20220510%WP3865%HOMO SAPIENS Novel intracellular components of RIG-I-like receptor (RLR) pathway IF1EA CHUK IFNK MAPK14 NFKB1 hCG_16983 IKBKB MAPK9 TNF-alpha IKBKG RNF125 ISG15 CYLD IFNA1 IFIH1 TBK1 TRAF2 DKFZp686M02159 IKBKE IF1DA1 MAP3K7 DDX58 TRIM25 TRAF6 IRF7 MAVS IRF3 TRAF3 LGP2 RIPK1 FADD MAPK10 CXCL10 IL8 CASP10 SNW1 ATG12 NFKBIB RELA TANK NLRX1 MITA DDX3Y AZI2 MAPK13 NFKBIA SIKE1 MAPK11 PIN1 TBKBP1 TRADD OTUD5 MAP3K1 ATG5 CXCL12 DDX3X IF2F MAPK8 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20220510%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy LRP5 PIK3R2 CTF1 PIK3R1 HDAC9 STAT3 MAP2K1 HDAC7 CHUK MAPK14 EDN1 NFKB1 DVL1 CTNNB1 IKBKB PIK3CA MYEF2 TNF-alpha MAPK1 IKBKG WNT3A MYLK3 FZD1 FZD2 PRKCB FGFR2 PIK3CD IKBKE RAC1 IGF1R MAP2K5 PRKG1 MAP2K4 MAP2K3 ROCK1 ROCK2 GATA4 TGFB1 CISH NFATC4 MAPK4 MAPK3 MAP2K6 EGF MAP3K7IP1 MAPK7 GSK3B RCAN1 ARHA PDPK1 CAMK2D IGF1 NPPB NPPA IL6ST PLCB2 MTOR NRG1 LRP6 CALM3 PPP3CA CALM2 FGF2 MYLK LIF MAP2K2 HDAC4 HDAC5 RAF1 EIF2B5 DKFZp686J04131 MAPK8 PLA2G2A CDK9 PIK3R3 CDK7 ALZHEIMER'S DISEASE%WIKIPATHWAYS_20220510%WP5124%HOMO SAPIENS Alzheimer's disease PIK3R2 PPIF PIK3R1 RTN3 PSEN2 KLC4 KLC3 KLC2 SHFM1 FZD10 TUBA2 TUBA8 SLC25A5 WNT16 SLC25A6 TUBAL3 BECN2 AMBRA1 DKFZp779O2152 ADRM1 WNT11 SLC25A31 FZD1 FZD2 FZD5 FZD7 FZD9 PIK3CD FZD8 APC2 CSNK1A1 MAPK3 WIPI1 ATP2A2 APC RB1CC1 RELA WNT5B CASP9 WNT3 GNAQ WNT10A RYR3 C12orf44 WIPI2 ATG14 DKK1 WNT2B NOS2 BAD GRIN2B CACNA1D ATG2A GRIN1 CACNA1F PSMD12 HEL-S-276 HEL-S-91n LRP6 CACNA1S CYCS CALM3 WNT7B PSMD13 CALM2 WNT7A IRS1 CSF1 PSMB6 PSMD9 PSMD6 PSMD7 PSMD4 FRAT2 PSMB2 IL1A PSMB3 IL6 PSMD2 CSNK2A3 ERN1 PSMD3 CSNK2A2 KIAA1149 PSMD1 CSNK1E ATF4 PSENEN DKK4 DKK2 SFRP4 CSNK2B PSEN1 MAPK8 PSMA4 PSMC6 PSMC4 PSMA2 PSMC1 XBP1 INSR EIF2S1 CTNNB1 HEL-S-162eP hCG_16983 CSNK1A1L APOE RTN4 HEL-S-61 CASP3 SNCA TRAF2 TNFRSF1A WNT4 APP ARAF DKFZp781H1925 FAS CALML6 ITPR2 CALML3 CALML4 PLCB2 DKFZp586M1622 PPP3CA IL1B PLCB1 PPP3R1 PTGS2 MCU VDAC3 CASP12 SLC25A4 INS ADAM10 WNT10B DVL1 DVL2 WNT1 TNF-alpha FZD3 DDIT3 WNT3A NAE1 EIF2AK2 HSD17B10 CYBB ULK2 ULK1 PLCB3 PLCB4 LRP5 MAP2K1 CACNA1C CHUK BRAF NFKB1 IKBKB MAPK9 PIK3CA MAPK1 AKT3 HRAS CSNK2A1 MAP3K5 ADAM17 CDK5 FADD MAPK10 GSK3B AXIN1 APAF1 AXIN2 CDK5R1 NRAS LPL MTOR KRAS FRAT1 APH1B PPP3R2 NRBF2 CHRFAM7A ATG2B IDE TUBA1C TUBA1B TUBA1A PPP3CC MME GPR83 TUBB TUBB2A KNS2 MAP2K2 PSMA8 TUBA3E TUBB4B TUBB4A RAF1 IRS4 TUBB8 TUBB6 PIK3R4 TUBB1 KIF5A PIK3R3 TUBA4A 1Q21.1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP4905%HOMO SAPIENS 1q21.1 copy number variation syndrome PRKAA1 CTNNB1 PRKAA2 GJA3 FMO5 BCL9 PRKAG1 PRKAG2 PRKAG3 F11R ACP6 GJA8 AMELX KIRREL1 NBPF12 CHD1L CXNK2 PYGO2 TJP3 AFDN PRKAB2 GJA5 PYGO1 PRKAB1 DKFZp686A1195 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20220510%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 MOLYBDENUM COFACTOR (MOCO) BIOSYNTHESIS%WIKIPATHWAYS_20220510%WP4507%HOMO SAPIENS Molybdenum cofactor (Moco) biosynthesis GPHN XDH MOCS2 MTARC2 SUOX MOCS1 AOX1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20220510%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY6 ADRB1 ADRB2 ADRA2C ADCY9 ADRA1D ADRA2A ADCY3 ADCY1 ADCY8 HEL-S-7a ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20220510%WP474%HOMO SAPIENS Endochondral ossification STAT5B PTHLH SPP1 MEF2C FGFR3 ALPL PLAT IGF2 ENPP1 ACAN IGF1R STAT1 SCIN FGF6A TGFB1 SOX9 VEGFA CDKN1C CHST11 CAB39 FRZB SOX6 IGF1 RUNX2 BMP6 PTCH1 BMPR1A GH1 GLI3 CALM3 CALM2 FGFR1 GHR THRA SOX5 MMP9 IHH ADAMTS5 KIF3A PTH1R FGF2 HMGCS1 ADAMTS4 COL10A1 NKX3-2 DDR2 CST5 TIMP3 COL2A1 MGP HDAC4 RUNX3 PTH OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20220510%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IF1IA1 CTF1 IFNK AREG IL17B TNF-alpha IF2B1 CCL4L2 IL-21 LOC728835 IL23A IL33 IL17F IFNA4 IFNA1 IF1AA3 IF1AA1 IF1AA6 IFNA13 IF1AA5 XCL1 IL17D IF1DA1 IL17C IF1AA4 IL17A IFNA14 CXCL6 CCL15-CCL14 CXCL17 CCL7 CXCL3 CCL17 CXCL13 IF1AA9 CCL25 CXCL5 CCL24 IF1AA8 CCL22 CCL28 CCL19 CCL26 CCL18 CCL11 TGFB1 IF1AB4 IL2 TSLP IF1AB1 PPBP VEGFA PF4 CCL21 CCL1 CSF3 IL25 CSF2 CSF1 CXCL1 CXCL2 IL10 IL15 IL13 IL4 IL3 IL1A IL6 IF2D IL5 IL27 IF2G IL7 IF2E CCL3L3 LIF PF4V1 IL19 CXCL14 XCL2 CCL2 LTA CCL14 EBI3 CCL13 CCL8 CCL16 CCL23 IF2F IL31 IL12B IL12A NFKB1 CNTF SPP1 TNFSF13 IL9 IL18 MMP3 CXCL9 TNLG7A IL1RN IL36A CCL5 IL36B CCL4 CCL3 IL1F5 CXCL10 CX3CL1 CCL27 CXCL11 IL8 OSM IL37 IL36G IL1F10 IL11 MMP9 EPO IL1B CXCL16 CXCL12 IF1IB1 IFNL2 IF1BA1 CCL20 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20220510%WP3878%HOMO SAPIENS ATM signaling in development and disease ATMIN CEP63 CHEK2 MDC1 RIF1 RNF8 NFKB1 PRKAA1 TP53BP1 HTATIP PRKDC CDK5R1 IKBKG STK11 CHEK1 RAD50 ATF2 ATR MRE11A H2AX MTOR ATM NBN TRIM28 HMGN1 SMC1A HEL-S-102 MAP3K5 LBR PPP5C HDAC4 TSC2 CDC2 PTPA CDK5 RASGRF1 AURKB PPM1D RBBP8 RNF20 GPCRS, CLASS B SECRETIN-LIKE%WIKIPATHWAYS_20220510%WP334%HOMO SAPIENS GPCRs, class B secretin-like GLP1R CALCRL GIPR GCGR SCTR GHRHR GPR64 PTH2R PTH1R CALCR EMR2 ADGRL1 ADGRE5 ADGRL4 CRHR1 ADGRL2 VIPR2 ADGRL3 ADCYAP1R1 CRHR2 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20220510%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity MYD88 IL1R1 F2R F2 TIMP1 CCR3 MMP9 NFKB1 IL1B PIK3CA HEL-S-134P TLR1 FCER1A HBEGF NLRP3 IRAK1 CCL2 PLA2G7 S100A9 IL18 IF2F GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20220510%WP2596%HOMO SAPIENS Gastric acid production GAS CCK CBLIF VIP SCT MUC6 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20220510%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol AKR1D1 EBI2 NR1i2 NR1H2 IL17B AKR1C4 CH25H INSIG1 ESR2 RORC HSD3B7 IL17F IL25 EPHX2 BAAT IL17D SLC27A5 IL17C DBP IL17A THEM5 LBP ACOT9 ACOX2 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 AMACR CYP3A4 EBP ACOT2 CYP46A1 ACOT6 SLC27A2 DHCR7 ACOT4 CYP7A1 CYP7B1 CYP27A1 AGE/RAGE PATHWAY%WIKIPATHWAYS_20220510%WP2324%HOMO SAPIENS AGE/RAGE pathway STAT5B STAT3 MAP2K1 CHUK INS INSR MAPK14 NFKB1 hCG_16983 IKBKB MAPK9 hCG_22119 MAPK1 DDOST MSR1 INHBB CASP3 ATF2 PRKCB MMP7 ALPL HEL-S-44 FOXO4 PRKCZ RAC1 NCF1 MMP14 STAT1 IRAK4 ROCK1 TIRAP FOXO1 JUN CDC42 SP1 MAPK3 HIF1A MYD88 PRKCA ARHA RELA CASP9 SHC1 NOS2 NFKBIA CYCS IRS1 MMP9 SRC SMAD2 HEL70 EGFR MMP2 RAF1 EZR MAPK8 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20220510%WP4504%HOMO SAPIENS Cysteine and methionine catabolism HEL-S-64p MTR DKFZp727E011 CDO1 AHCY HEL-S-61p CTH MAT1A hCG_2001986 GCLC ETHE1 SUOX pcap EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20220510%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2 XDH NOS2 GLNG AOX1 COX1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20220510%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells ASIP MITF-C PRKACG TYR PLCB1 GPR143 POMC MC1R GNAQ PLCB2 PLCB3 PLCB4 PRKCB PMEL ADCY9 TYRP1 ARRB2 CREB1 GNAS VEGFA GNA15 PKC-GAMMA CALCIUM SIGNALING PATHWAY IN ATAXIA%WIKIPATHWAYS_20220510%WP4760%HOMO SAPIENS PKC-gamma calcium signaling pathway in ataxia ATP2B2 CACNA1A PLCB1 GRIA2 GNAQ PLCB2 PLCB3 TRPC3 RYR3 PLCB4 GRIA3 GNA11 GRIA4 GNA14 HOMER3 GNA15 CA8 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20220510%WP691%HOMO SAPIENS Tamoxifen metabolism CYP1B1 CYP2C8 SULT1A1 SULT1E1 SULT2A1 UGT2B7 CYP2C19 UGT1A10 CYP3A4 UGT1A4 CYP2C9 UGT1A8 UGT2B15 CYP2A6 CYP2E1 CYP1A2 CYP1A1 TP53 NETWORK%WIKIPATHWAYS_20220510%WP1742%HOMO SAPIENS TP53 network CDKN1A BOK MDM2 TNFSF10 GADD45A TP73 BCL2 TP63 OTX2 BBC3 CDKN2A SUMO1 PMAIP1 ATM MYC BAX UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20220510%WP4925%HOMO SAPIENS Unfolded protein response PPP1R15A HEL-S-89n XBP1 EIF2S1 MBTPS2 hCG_16983 IL1B TXNIP hCG_20684 BCL2 DKFZp686A24188 MBTPS1 ERN1 DDIT3 BBC3 ATF4 BCL2L11 PMAIP1 RTCB DKFZp781H1925 NFE2L2 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20220510%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP1B1 CYP17A1 FLJ16008 CYP2A13 CYP2F1 CYP4B1 CYP2W1 CYP20A1 CYP24A1 CYB5R1 CYB5R4 CYB5R3 CYB5B CYP2B6 CYP2C19 CYP4A22 POR CYP46A1 CYP4F12 CYP4Z1 DKFZp686I24235 CYP2C9 CYP27A1 CYP1A2 CYP2U1 CYP1A1 CYP27B1 CYP4F22 CYP4X1 CYP11A1 CYP11B2 CYP4F2 CYP4F3 CYP4F11 CYP4F8 CYP26A1 CYP2S1 CYP4A11 CYP2A6 CYP26B1 CYP4V2 CYP2R1 CYP2J2 CYP2C8 CYP51A1 CYP3A4 CYP3A7 CYP3A43 CYP7B1 CYP7A1 CYP2A7 CYP26C1 CYP2E1 DNA REPLICATION%WIKIPATHWAYS_20220510%WP466%HOMO SAPIENS DNA replication ORC3 POLD3 ORC2L MCM7 POLD4 ORC1L POLD2 CDK2 RPA1 CDT1 POLA1 DBF4 RPA4 MCM5 MCM6 MCM2 POLE CDC45 PRIM1 PRIM2A POLA2 ORC6L CDC6 RPA3 POLE2 RFC3 RFC4 GMNN MCM10 UBC RFC1 PCNA RFC2 AMINO ACID METABOLISM%WIKIPATHWAYS_20220510%WP3925%HOMO SAPIENS Amino acid metabolism TPH1 OTC HEL-S-64p ACLY HEL-S-30 PNMT IDH1 HEL-S-133P P4HA2 TDO2 DDC HEL-S-4 ADH1C LARS2 HEL-S-61p HEL-S-53e CS ACO2 ARG2 FARSB SRM HIBADH SMS ALDH18A1 EPRS1 ARG1 TH ALDH7A1 HDC DKFZp686B20267 ADH7 GLUD1 VARS HAL WARS HMGCL RARS1 GPT2 FTCD DKFZp727E011 MARS2 BCAT1 PPM1L ADH5 PCK1 ACSS1 ASNS IARS CTH FH MDH2 OGDH SUCLG1 DLD HEL-S-32 GCLM DKFZp686O15119 PIG59 ACADM MAOA PDHA1 G6PC2 ASS PC GOT2 HEL-75 DBH EHHADH SDHA PDHX TPO CAD PDK4 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20220510%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis FAS HTRA2 AIFM1 hCG_16983 APAF1 TNFSF6 CASP9 BCL2 BAK1 PRF1 CASP6 CASP3 FADD DIABLO CYCS BAX ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20220510%WP554%HOMO SAPIENS ACE inhibitor pathway CTSG CMA1 ATP6AP2 MGRA CYP11B2 REN ACE2 TGFB1 NR3C2 AGTR1 AGTR2 BDKRB2 BDKRB1 KNG1 NSP1 FROM SARS-COV-2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20220510%WP5027%HOMO SAPIENS nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell EIF3F EIF3D EIF2S1 EIF1AX EIF3S1 SUI1 EIF5 EIF3S2 EIF2S3 EIF3S9 EIF3S8 EIF3G EIF3E EIF3S3 EIF3A EIF2S2 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20220510%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A1 SULT1E1 SULT2A1 HEL-75 SULT1C2 SULT1A2 SULT1C4 SULT1B1 PAPSS2 PAPSS1 ST1A5 SULT2B1 SULT1C3 SULT6B1 HIPPO SIGNALING REGULATION PATHWAYS%WIKIPATHWAYS_20220510%WP4540%HOMO SAPIENS Hippo signaling regulation pathways INSR CTNNB1 TCF7L1 TAFAZZIN CDH11 GNAI3 PRKCI GNA11 FGFR4 EPHA2 FGFR3 PRKCB YY1AP1 FGFR2 CSF1R FLT1 PRKAG1 PRKAG2 PRKAG3 KIT CDH9 PRKCZ CDH8 RAC1 CDH16 CDH4 CDH10 CDH12 IGF1R CDH15 TEAD4 CDH17 PRKAR1B CDH18 LATS1 LATS2 CDH19 CDH24 PRKAB2 TEAD2 TEAD3 CDC42 NGFR PRKCQ PRKAB1 KDR PRKCA ARHA DKFZp586H0919 NTRK1 PRKACG PRKAA1 PRKCH PRKAR1A PRKCE PRKAA2 PLCB2 TCF7L2 GNAQ PRKD3 MTOR GNAS GNAL FLT3 CDH6 CDH2 FGFR1 PLCB1 FLT4 SMAD2 PLCB3 NF2 PLCB4 NTRK2 PDGFRA EGFR DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20220510%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets STAT3 ID2 CSF2 CSF1 SPI1 IKZF1 RUNX2 FLT3LG IRF4 BATF3 IRF8 TPO TCF4 B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP23%HOMO SAPIENS B cell receptor signaling pathway HCLS1 PIK3R2 PIK3R1 MAP2K1 CHUK BRAF PTPN11 PIP5K1A MAPK14 PIP5K1C NFKB1 IKBKB MAPK9 GSK3A MAPK1 CRKL IKBKG IRF4 MEF2C ATF2 PRKCB STM7 RAC1 INPP5D RPS6KA1 VAV1 MAP3K7 HRAS RASGRP3 CRK PTPRC RAPGEF1 FOXO1 MAP4K1 JUN GAB2 SYK CDC42 CD19 LYN VAV2 GTF2I TEC CD81 DAPP1 LCK CD79B MAPK4 PTPN18 BTK MAP2K6 CBL PTPN6 LAT2 SOS1 MEF2D GSK3B CR2 PDPK1 CAMK2A RELA SHC1 NFATC2 TIEG2 REL BCL6 FLJ00308 DKFZp434N101 BLK CREB1 NFKBIA MAX GRB2 E2F3 FLJ00120 PLCG2 FYN BLNK MAP2K2 BCL10 NCK1 RAF1 NFATC3 CD79A MAPK8 MYC CD22 IRINOTECAN PATHWAY%WIKIPATHWAYS_20220510%WP229%HOMO SAPIENS Irinotecan pathway BCHE ABCC1 CES2 ABCG2 CES1 ABCC2 UGT1A1 UGT1A9 SLCO1B1 UGT1A10 NPC1 CYP3A4 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA-OXIDATION%WIKIPATHWAYS_20220510%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta-oxidation ACSL1 PECR FACL4 SLC25A20 ACADS EHHADH ACSL3 ACSF2 ACADVL ACADL CPT2 ACADM NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20220510%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG10 ATG12 INS MAP1LC3A FLJ10035 INSR ATG5 BCL2 AMBRA1 TMEM49 TSC2 ATG14 TSC1 SH3GLB1 ULK2 UVRAG ULK1 ATG9B CHAF1A ATG3 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20220510%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells PRPS1L1 RPE DERA HEL107 RPIA HEL-S-304 PTDINS(4,5)P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20220510%WP5199%HOMO SAPIENS PtdIns(4,5)P2 in cytokinesis pathway RAB35 KIF23 HEL70 ARHA MYL2 RDX EZR PDGFR-BETA PATHWAY%WIKIPATHWAYS_20220510%WP3972%HOMO SAPIENS PDGFR-beta pathway GRB2 JAK1 STAT5B STAT3 PIK3R1 MAP2K1 SOS1 MAP3K1 PRKCA FOS STAT1 HRAS MAP2K4 PIK3CA JUN SHC1 STAT6 EIF2AK2 PRKCB DKFZp434N101 RAF1 MAPK3 MAPK8 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX (PDHC)%WIKIPATHWAYS_20220510%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc) ACLY HEL60 IDH1 DLAT PCK1 SDHA CS PDHA1 FH OGDH SUCLG2 DLD HEL-S-32 PC IL-9 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP22%HOMO SAPIENS IL-9 signaling pathway PIK3R2 GRB2 IL9R JAK1 STAT5B STAT3 PIK3R1 MAP2K1 STAT1 JAK3 IL2RG MAPK1 MAP2K2 IL9 MAPK3 CDK9 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20220510%WP15%HOMO SAPIENS Selenium micronutrient network GPX1 INS GPX4 INSR NFKB1 ALOX5 KYNU KMO TNF-alpha SERPINA3 SERPINE1 HEL-S-44 HBB SCARB1 PLAT FLAD1 TXN FGA GPX6 HBA2 F7 MTR DKFZp727E011 ABCA1 HEL-S-2a F2 CRP SAA4 GGTLA4 LDLR PLG DKFZp564M2422 APOB HEL-S-78p CTH ALB SAA1 SAA2 NFKB2 HEL-S-97n SEPHS2 HEL-S-302 SELENOO SELENON GGTLC2 DIO1 SELENOM SELENOW RELA SELENOV MPO SELENOT SELENOF SELENOK SELENOI SELENOH PRDX3 PRDX5 MSRB1 SELS GPX2 GPX3 APOA1 XDH HEL-75 IL1B IL6 SELENOP PTGS2 CCL2 IF2F PTGS1 TXNRD2 ALOX5AP ALOX15B EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20220510%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis AGO2 XPO5 DICER1 DROSHA DGCR8 THEX1 15Q11.2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP4940%HOMO SAPIENS 15q11.2 copy number variation syndrome TUBGCP5 CYFIP1 TUBGCP6 FMR1 TUBGCP4 NIPA1 NIPA2 MECHANOREGULATION AND PATHOLOGY OF YAP/TAZ VIA HIPPO AND NON-HIPPO MECHANISMS%WIKIPATHWAYS_20220510%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms CTNNA1 MAP4K2 ITGB8 CTNNB1 ITGB7 MAPK9 TAFAZZIN ACTA1 YWHAQ YY1AP1 ACTG2 LIMD1 ACTG1 PS1TP5BP1 ITGB5 TEAD4 ITGB3 LATS1 SRC HEL-S-31 MAP4K1 TEAD2 TEAD3 ITGB6 NF2 ITGB1 PAK1 ACTA2 PAK6 SGMS1 PAK4 ITGB4 MAPK10 MAPK8 OMEGA-9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20220510%WP4724%HOMO SAPIENS Omega-9 fatty acid synthesis FADS2 FADS1 ELOVL5 ELOVL2 ELOVL3 ACSL1 ACOT2 FACL4 ACSL3 ELOVL1 FASN SCD5 SCD ELOVL6 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20220510%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 CD40 PTPN22 CCR6 MHC2TA PADI4 ITGAV CD244 PHF19 TRAF1 CTLA4 IL6ST STAT4 HLA-DRB1 BLK IL2RA IRF5 SLC22A4 GDNF/RET SIGNALING AXIS%WIKIPATHWAYS_20220510%WP4830%HOMO SAPIENS GDNF/RET signaling axis HSPB11 GATA3 SPRY1 RET ROBO2 EYA1 SALL1 SLIT2 CTNNB1 FAT4 GREM1 FOXC2 SOX17 FOXC1 PAX2 GDNF IFT27 GLI3 BMP4 AGTR2 SOX11 LHX1 INSULIN SIGNALING%WIKIPATHWAYS_20220510%WP481%HOMO SAPIENS Insulin signaling PIK3R2 PIK3R1 MAP3K12 INPPL1 CBLC RPS6KA5 GRB10 PRKCI PRKCB PIK3CD PIK3C2G PIK3C2A STXBP1 PRKCZ RAC1 RPS6KA4 IGF1R MAP2K5 SOCS1 CRK FOXO1 RAPGEF1 MAP4K1 PRKCQ ARF6 MAPK6 MAPK4 MAPK3 CBL MAPK7 TRIB3 MAP3K2 MAP4K2 RAB4A SLC2A4 PRKCH STX4A VAMP2 IRS1 HEL-S-31 MINK1 GRB14 SOCS3 MAPK8 EIF4EBP1 GYS2 GYS1 GYG1 MAP2K1 XBP1 PTPN11 PPP1R3A FOS INSR MAPK14 PFKM IKBKB MAPK9 PIK3CA ARF1 MAP3K11 GSK3A MAPK1 HEL-S-61 DKFZp686M02159 RPS6KA3 RPS6KA6 RPS6KA2 ENPP1 RPS6KA1 MAP3K8 MAP3K7 HRAS MAP2K4 MAP3K5 MAP2K3 EGR1 JUN SHC2 SHC3 DKFZp781N0293 TSC2 MAP3K6 MAP3K10 TSC1 MAP3K13 FLOT1 FLOT2 MAP2K6 PTPRF SGK1 MAPK10 SGK2 PTPN1 HEL-S-42 SOS1 SOS2 PRKCA GSK3B SH2B2 FOXO3A CAP1 PDPK1 PRKAA1 TBC1D4 PRKAA2 SHC1 MTOR MAPK13 MAPK11 RPS6KB1 RHEB PTEN RPS6KB2 GRB2 MYO1C MAP3K1 SNAP25 PFKL KIF3A INPP4A STXBP3 RRAD STXBP4 EHD1 EHD2 SNAP23 CYTH3 SNX26 EIF4E MAP2K2 RAF1 IRS4 DKFZp686J04131 PIK3R4 PIK3R3 PROLACTIN SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2037%HOMO SAPIENS Prolactin signaling pathway PIK3R2 PIK3R1 STAT5B STAT3 MAP2K1 PTPN11 FOS MAPK14 PPIB NFKB1 MAPK9 PIK3CA MAPK1 CASP3 RAC1 JAK1 RPS6KA2 IRF1 VAV1 SIRPA SOCS1 HRAS STAT1 JUN GAB2 RPS6 VAV2 PAK1 CISH TEC PRL ZAP70 MAPK3 CBL PTPN6 PTPN1 DKFZp666O0110 SOS1 NFKBIB GSK3B RELA PRLR SHC1 AGAP2 NOS2 YWHAG YWHAZ MTOR NFKBIA RPS6KB1 GRB2 IRS1 FLNA SRC FYN HEL-S-130P ITGB1 HEL-S-69p NEK3 MAP2K2 SOCS2 RAF1 PXN SOCS3 MAPK8 MYC ERBB2 EIF4EBP1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20220510%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PIK3R2 PIK3R1 STAT3 MAP2K1 RRAS BRAF PIK3CA NRG2 BCL2 MAPK1 CCND1 FGFR3 PRKCB FGFR2 PIK3CD TGFA HGF JAK1 RRAS2 AKT3 IGF1R HRAS SHC4 SHC2 SHC3 ERBB3 RPS6 PDGFD PDGFC MAPK3 VEGFA ARAF EGF KDR SOS1 SOS2 GSK3B PRKCA FOXO3A PDPK1 IGF1 SHC1 NRAS GAS6 NF1 BAD DKFZp434N101 BCL2L11 MTOR RPS6KB1 PTEN NRG1 RPS6KB2 KRAS GRB2 FGF2 IL6R PLCG2 SRC IL6 EIF4E BCL2L1 PDGFRA MAP2K2 EGFR RAF1 AXL MYC PDGFA ERBB2 PIK3R3 EIF4EBP1 BAX BONE MORPHOGENIC PROTEIN (BMP) SIGNALING AND REGULATION%WIKIPATHWAYS_20220510%WP1425%HOMO SAPIENS Bone morphogenic protein (BMP) signaling and regulation SMAD4 TOB1 SMAD1 BMPR1A BMPR2 NOG TOB2 BMP2 RUNX2 SMURF1 SMAD6 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20220510%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways PLEKHM1 TNFSF11 CLCN7 NFKB1 OSTM1 IKBKB SNX10 TNFRSF11A RAB7A TRAF6 TCIRG1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20220510%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 ESTROGEN METABOLISM%WIKIPATHWAYS_20220510%WP697%HOMO SAPIENS Estrogen metabolism STS CYP1B1 SULT1A1 SULT1E1 UGT2B7 GSTM1 CYP3A4 UGT1A1 UGT1A3 UGT1A9 ARSL NQO1 CYP1A2 CYP1A1 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20220510%WP1434%HOMO SAPIENS Osteopontin signaling MAP2K1 CHUK ITGAV MMP9 NFKB1 IKBKB ITGB3 RELA MAPK3 SPP1 DKFZp686J04131 MAPK1 CREATINE PATHWAY%WIKIPATHWAYS_20220510%WP5190%HOMO SAPIENS Creatine pathway HEL-S-20 HEL-S-29 SLC6A8 NETWORK MAP OF SARS-COV-2 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP5115%HOMO SAPIENS Network map of SARS-CoV-2 signaling pathway IFI27 TRPM2 APOH APOD RRAS HRG CTSZ CD14 SERPINA10 IL16 GP1BA HMFT1766 IFI6 HP IFI44L FAM83A LGALS3BP TRO CPN1 ITIH4 DKFZp686N0152 ITIH3 APOC1 IL33 RAC1 CD226 IL17A PIAS1 CXCL6 CXCL3 CXCL13 CXCL5 CCL11 LARP1 LCK TP53I3 CD8B1 PF4 ZAP70 TF CD8A PTPN6 ITCH DKFZp762B153 CCL21 CASP9 CCL1 SMAD1 RRM2 DKFZp781O1323 CXCL1 CXCL2 IL10 TNFSF10 IL13 IL4 IL1R2 IL1A IL6 IL5 IL7 HLA-DRA HLA-DRB1 BIRC5 IF2F MAPK8 EIF4EBP1 IL12A JUNB hCG_16983 CASP5 NLRP3 SELP NLRP1 CASP3 SERPINE1 HBD IL9 HBB IL18 HEL-S-81p TRAF2 FGA VPS18 VPS33A CRP VPS11 VPS16 EGR1 BST2 JUN HEL-S-78p ALB SAA1 SAA2 CDC2 VPS41 DEPTOR CCNB2 CCNB1 APOL1 IL1B FYN PTGS2 EIF4E CAMK4 NFATC3 CEBPB CCL20 TNF-alpha AHR IF2B1 IL-21 IL18RAP IFITM1 IFIH1 TBK1 MX1 IFIT1 JAK1 IF1DA1 PARP2 CCL15-CCL14 STAT1 DDX58 CCL22 CCL26 ACE2 MAVS IRF3 TRAF3 IRF9 NFKB2 PRKCQ CD163 HLA-DRB5 NRF CD3G PRG3 CD3E CD2 HIF1A MMP25 IGLL1 CD247 EIF4A2 DDIT4 APOA2 ULK1 APOA1 OAS2 TGFBR2 FLJ00120 CCL2 CCL8 IL8RB FOS IKBKG raptor ACTG1 CTSL PS1TP5BP1 CCR6 CCR5 CXCL9 MLST8 LBP TRAF6 RPS6 IRAK1 CCL5 CCL4 CCL3 C1QBP C8A CCL27 CXCL10 AKT1S1 IL8 MYD88 CXCR1 NTRK1 STEAP3 MTOR HEL-S-72p C1S CFH RHEB C1R CFI CFP FGF2 CXCL16 HEL-S-130P CXCL12 IFITM3 TPO VPS36 GTSE1 GABARAPL2 WDR74 GUT-LIVER INDOLE METABOLISM %WIKIPATHWAYS_20220510%WP3627%HOMO SAPIENS Gut-liver indole metabolism CYP2E1 DRAVET SYNDROME%WIKIPATHWAYS_20220510%WP5200%HOMO SAPIENS Dravet syndrome CALM3 CALM2 RICTOR MLST8 NFKB1 CAMK2A PIK3CA MAPKAP1 SCN3A hCG_2039433 SCN1B SCN3B SCN2B SCN1A MTOR MAPK11 SCN4B PURINE METABOLISM%WIKIPATHWAYS_20220510%WP4792%HOMO SAPIENS Purine metabolism ADA IMPDH HPRT1 XDH ADSL HEL-S-70p AMPD1 hCG_40733 APRT HEL-S-156an ADSS CELL DIFFERENTIATION - INDEX%WIKIPATHWAYS_20220510%WP2029%HOMO SAPIENS Cell differentiation - index TLX3 STAT3 TLX1 MEF2D MEF2C HDAC5 TLX2 MYOD1 LEFTY2 LEFTY1 MEF2B METABOLISM OF ALPHA-LINOLENIC ACID%WIKIPATHWAYS_20220510%WP4586%HOMO SAPIENS Metabolism of alpha-linolenic acid PTGS2 FADS2 ALOX5 FADS1 ALOX15 ALOX12 VITAMINS A AND D - ACTION MECHANISMS%WIKIPATHWAYS_20220510%WP4342%HOMO SAPIENS Vitamins A and D - action mechanisms RARA RXRA NR1i1 TRANS-SULFURATION AND ONE-CARBON METABOLISM%WIKIPATHWAYS_20220510%WP2525%HOMO SAPIENS Trans-sulfuration and one-carbon metabolism DHFR2 PSPH AHCYL1 HEL-S-64p PSAT1 AHCY TYMS HEL-S-61p MAT1A DNMT3B hCG_2001997 AHCYL2 PHGDH MTHFD2L MTHFD1L DHFR MTR MTHFD1 DKFZp727E011 MTHFD2 SHMT1 HEL-S-51e CTH DNMT3L GCLC GCLM MRNA, PROTEIN, AND METABOLITE INDUCATION PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20220510%WP3953%HOMO SAPIENS mRNA, protein, and metabolite inducation pathway by cyclosporin A ATF4 SLC7A11 SLC7A5 KEAP1 SLC3A2 NFE2L2 COVID-19, THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20220510%WP4927%HOMO SAPIENS COVID-19, thrombosis and anticoagulation F13A1 F2 F13B PLG FGA HEL-S-78p METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20220510%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 PIK3R1 E2F3 CDK6 MYC KREBS CYCLE DISORDERS%WIKIPATHWAYS_20220510%WP4236%HOMO SAPIENS Krebs cycle disorders DKFZp564P2062 FH PDHX SUCLG2 DHTKD1 SUCLG1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20220510%WP4823%HOMO SAPIENS Genes controlling nephrogenesis CXCR4 KDR CTNNB1 HEL-S-28 TCF21 PAX2 TCF2 GDNF CD36 EMX2 FGFR2 GLI3 SIX1 HOXD11 LHX1 HOXA11 ETV4 KIRREL1 LAMB2 ROBO2 RET EYA1 SLIT2 FOXC2 NCK2 FOXC1 FGF8 WT1 CD2AP LMX1B CXCL12 ITGB1 NPHS1 DKFZp434N181 NPHS2 WNT4 SHH NCK1 FOXD1 VEGFA AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20220510%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits POSTN CXCR4 VCAM1 DKFZp586H0919 NOTCH1 TCF7L1 VEGFA TNC SRC VHL CYTIP TCF7L2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20220510%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum BRCA1 HIST1H4J CETN2 XPA XPC GTF2H2C_2 GTF2H2 GTF2H3 DDB2 GTF2H5 CUL4B CUL4A ERCC3 ERCC1 POLD3 POLD4 POLK POLD2 RPA1 RAD18 RBX1 GPS1 DKFZp434C189 HMGN1 ERCC2 SLX4 HIST1H2AC SLX4IP PARP1 LIG3 POLE CHD1L RPA3 POLE2 RFC3 MNAT1 RFC4 RFC1 CCNH PCNA XAB2 LIG1 H3F3A RFC2 DDB1 POLE4 POLE3 CDK7 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20220510%WP4298%HOMO SAPIENS Acute viral myocarditis IL12B PIK3R1 STAT3 IL12A EDN1 hCG_16983 hCG_20684 NOD2 BCL2 TNF-alpha MAPK1 PYCARD ABL2 CCND1 CASP6 CASP3 MYH6 MICA RAC3 JAK1 PS1TP5BP1 AIF1 CCR5 PARP1 CD80 CAAP1 CCR3 CXADR CHRAC1 SOCS1 BNIP2 STAT1 TICAM1 TGFB1 TLR5 TLR4 IL2 TLR3 NFKB2 MAPK3 JKAMP PABPC1 DAG1 SOS1 CXCR4 GSK3B SGCD SGCB SGCG HEL-S-28 CASP9 HLA-DMA EIF4G1 CREB1 DMD CYCS AAG1 MMP9 IL10 DFFB DFFA SRC IL6 FYN CD55 BCL2L1 IF2F CD40LG BAX CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20220510%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response IL8 VCAM1 ITGA4 C6 C7 IL1A TNF-alpha IL6 ITGB1 SELP SELPLG HEL-S-62p KNG1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20220510%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOE MTTP LIPC APOC1 LPL APOA4 DGAT1 APOA2 SCARB1 APOA1 ABCG8 ABCG5 APOA5 ABCA1 ACSS1 LDLR PDIA2 APOC2 APOB HMGCR PLTP DKFZp686B0215 CYP7A1 FDFT1 SOAT1 APOC3 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20220510%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 NODAL NKX2-1 SHH TGIF1 GLI3 TGIF2 FOXG1 FGF8 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome STAT5B SLC51A SLC51B ADAM10 RNF8 DYNLT2B NCBP1 NCBP2 DYNLT1 DYNLT3 DYNC2I2 DYNLRB2 SIRT1 FBXW7 CEP19 PIGX UBXN7 SMCO1 JUN HEL-S-71 FNDC8 PIGM MFI2 MYCBP2 TGFB1 FBXO45 BRINP1 ZDHHC19 TM4SF19 CEP350 MCRS1 MAD2L1BP WDR53 ZNF76 TF HIF1A DKFZp686O0451 SLC40A1 HAMP DYNC2LI1 HFE DYNC2H1 DYNLL2 DNCL1 NRROS NF2 PXN MYC PIK3R3 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20220510%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells CDKN1A PLA2G10 PLA2G3 PLA2G5 ALOX5 HRAS PLA2G12A PLA2G4F PLA2G6 PLA2G12B PLA2G4D PLA2G4E PLA2G4C PTGS2 PLA2G1B PLA2G2D PLA2G7 SLCO2A1 COCAINE METABOLISM%WIKIPATHWAYS_20220510%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CES2 CES1 CYP3A4 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20220510%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ITGAV HEL114 ITGB3 MYLK JUN MAPK1 ACTN1 PRKCQ DKFZp434N101 CREB1 MYL2 MAPK3 PXN LPP DKFZp686A1195 MFAP5 DKFZp666O0110 T-CELL ACTIVATION SARS-COV-2%WIKIPATHWAYS_20220510%WP5098%HOMO SAPIENS T-cell activation SARS-CoV-2 IL12B PIK3R1 IL12A MAP2K1 CHUK FOS NFKB1 IKBKB TNF-alpha MAPK1 IKBKG IL23R CCND1 IL23A raptor PIK3CD ICOS IFNAR2 CD80 MLST8 IF1DA1 IL17A HRAS TYK2 JUN CCL28 CCL19 STAT4 IL2 TSC2 PRKCQ IFNAR1 LAT TSC1 LCK CD3G ZAP70 MAPK3 CD3E IRF2BPL DEPTOR CD247 SOS1 RICTOR MYD88 GSK3B FOXO3A PDPK1 RELA NFATC1 DKFZp434N101 MTOR NFKBIA PTEN RHEB CDKN1A GRB2 FLJ00120 IL4 CD3D CTLA4 GRAP2 PPP3CC FYN HLA-DRA HLA-DRB1 BCL2L1 LCP2 CDKN2A MAP2K2 LTA BCL10 RAF1 IF2F IL12RB1 IL18R1 BAX MEASLES VIRUS INFECTION%WIKIPATHWAYS_20220510%WP4630%HOMO SAPIENS Measles virus infection PIK3R2 PIK3R1 STAT3 CCND1 EIF2AK2 CCND2 PIK3CD IFNA4 IFNA1 IFIH1 TBK1 MX1 IF1AA3 IKBKE IF1AA1 JAK1 IFNAR2 IF1AA6 OAS1 IFNA13 IF1AA5 IF1DA1 IF1AA4 IFNA14 STAT1 DDX58 IF1AA9 JAK3 IL2RB STAT2 IF1AA8 TYK2 CDK6 MAVS IRF3 CCNE1 TRAF3 IF1AB4 IL2 IRF9 NFKB2 IFNAR1 IF1AB1 CDK4 IL2RA CD3G CD3E LNIR SLAMF1 RCHY1 FCGR2B TNFAIP3 RAB9B RELA CASP9 IL2RG EIF2AK1 EIF2AK4 CDK2 BAD NFKBIA TRADD OAS2 CYCS OAS3 ADAR CD3D IL1A IL6 CSNK2A3 CSNK2A2 BCL2L1 CSNK2B MAPK8 BAX IL12B STAT5B IL12A CHUK FOS EIF2S1 NFKB1 hCG_16983 IKBKB TNFSF6 MAPK9 PIK3CA TP73 BCL2 IKBKG BBC3 CASP3 TLR7 MAP3K7 CSNK2A1 IRAK4 JUN CD209 TRAF6 IRF7 TLR9 TLR4 IRAK1 RAB9A FADD CCND3 MAPK10 DKFZp781H1925 FAS CCNE2 MYD88 NFKBIB CDKN1B APAF1 BAK1 EIF3S3 CD46 HEL-S-72p IL1B HEL70 HSPA1B HSPA2 PIK3R3 KETONE BODIES SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20220510%WP311%HOMO SAPIENS Ketone bodies synthesis and degradation HMGCL ACAT1 OXCT1 ENERGY METABOLISM%WIKIPATHWAYS_20220510%WP1541%HOMO SAPIENS Energy metabolism PPARG MEF2D GSK3B TFB1M FOXO3A MED1 MAPK14 NR1C1 ESRRA TFB2M PRKAA1 PPRC1 NR1C2 PRKAA2 GABPA NCOA1 CAMK2G TFAM UCP3 MEF2C ATF2 EP300 CREB1 PRKAG1 PRKAG2 UCP2 PRKAG3 MEF2B PPARGC1B PPP3CA PRMT1 SIRT1 MYBBP1A PPP3R2 PPARGC1A SIRT3 FOXO1 PRKAB2 PPP3R1 PPP3CC NRF1 CAMK4 RXRA HDAC1 PRKAB1 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20220510%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HDAC4 CXNK2 ERG HCN4 KCNE1 IGF1 HCN2 HAND2 KCNJ2 TMSB4X NAD METABOLISM, SIRTUINS AND AGING%WIKIPATHWAYS_20220510%WP3630%HOMO SAPIENS NAD metabolism, sirtuins and aging PPARG PARP1 TFAM FOXO3A SIRT1 ROS1 NFKB1 PBEF1 SIRT3 FOXO1 HIF1A SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20220510%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism FFAR2 GCG SLC2A4 NR1C2 PYY FFAR3 IL-3 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP286%HOMO SAPIENS IL-3 signaling pathway PIK3R2 IL8 PIK3R1 STAT5B STAT3 MAP2K1 SOS1 PTPN11 FOS SHC1 BCL2 MAPK1 CRKL YWHAQ HEL-S-1 BAD PIK3CD JAK1 GRB2 INPP5D ENPP3 CCR3 VAV1 IL3RA HRAS SRC IL3 RAPGEF1 JUN GAB2 CSF2RB FYN TGFB1 SYK LYN BCL2L1 RAF1 MAPK3 CBL PTPN6 MAPK8 CD69 IL5RA DEVELOPMENT OF URETERIC COLLECTION SYSTEM%WIKIPATHWAYS_20220510%WP5053%HOMO SAPIENS Development of ureteric collection system GATA3 SPRY1 CTNNB1 FST TCF2 CCND1 RARA WNT11 GDNF FGFR2 BMP4 SIX1 HOXD11 LHX1 HOXA11 ETV4 SLIT2 FOXC1 WT1 BMP5 GRIP1 NR1B3 RARB HEL-S-28 GREB1L PBX1 SMO ROBO1 PAX2 BMPER SIX2 CTDNEP1 FREM1 ANOS1 FREM2 GPC3 SMAD1 GDF11 BMPR1A CRIM1 BMPR2 FRAS1 GLI3 BMP2 ROBO2 RET EYA1 SALL1 FAT4 CELSR1 ITGB1 SHH FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20220510%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 GHR EPHX2 LDLR APOB PCSK9 USF1 PLTP LIPC LPL APOA4 GPIHBP1 APOA2 APOA1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20220510%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling STAT3 HEL-S-15 IL1R1 IL10RB IL10RA TNF-alpha PRKCB GFAP PHGDH JAK1 STAT1 TGFB1 TRAF5 GRIA4 NFKB2 DLD MAPK3 NELF ADCY3 PIG59 SLC2A3 CAMKK1 CAMK2D CAMKK2 TNFRSF1B CAMK2A IGF1 IL6ST PPP1CC SMAD4 HEL-S-80p STAT6 CAMK2G PDHA1 SLC1A1 SLC1A4 GRIN2B CREB1 SLC38A3 GRIN1 SLC38A5 DAO GRIK5 GRIK3 GRIK1 DKFZp762A2415 CALM3 LRRC8D CALM2 TGFBR2 LRRC8B GRIK2 TGFBR3 DISC1 IRS1 LRRC8E IL10 IL6R IL13 IL4 IL1R2 IL1A IL6 PLCB3 PLCB4 LIF GRIN3B GRIN3A LTA IFNGR1 IFNGR2 IF2F SOCS3 IL12B IL12A FOS INSR NFKB1 CNTF BCL2 MAPK1 SLC1A2 TNFRSF1A SHMT1 HEL-S-51e LRRC8C GRIA3 SLC6A9 NGF PSPH DKFZp686O15119 PRKCA PSAT1 ARC GRIA2 ADCY1 ADCY8 PLCB2 BDNF SLC7A10 DLAT FGF2 SLC1A3 IL1B PLCB1 SMAD2 TGFBR1 SLC17A6 GRM8 SLC17A7 IL13RA1 GRM2 CAMK4 SLC38A1 GLS2 GRM4 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20220510%WP391%HOMO SAPIENS Mitochondrial gene expression PPARGC1B PPP3CA MTERF3 POLRMT TFB1M HCFC1 ESRRA TFB2M MTERF1 PPRC1 PPARGC1A MYEF2 GABPB2 GABPA TFAM NRF1 CREB1 CAMK4 SP1 NOTCH SIGNALING%WIKIPATHWAYS_20220510%WP268%HOMO SAPIENS Notch signaling PSEN2 DLL3 DLL4 DTX1 DVL1 DVL2 HES5 JAG2 RBPJ DKFZp586M1622 LFNG DKFZp762E1511 KAT2B RBPJL APH1B NCOR2 DTX2 DTX3 KCNJ5 MAML1 DTX3L ADAM17 KAT2A MFNG NUMB DTX4 DKFZp434N181 HES1 NOTCH3 NOTCH1 HDAC2 CREBBP PSEN1 CTBP2 HDAC1 CTBP1 BENZO(A)PYRENE METABOLISM%WIKIPATHWAYS_20220510%WP696%HOMO SAPIENS Benzo(a)pyrene metabolism CYP1B1 AKR1C1 EPHX1 AKR1C2 HEL-S-165mP AKR1C4 CYP1A1 CYP3A4 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20220510%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20220510%WP2113%HOMO SAPIENS Type III interferon signaling JAK1 IF1IA1 IRF9 IL10RB IFNLR1 STAT1 STAT2 IF1IB1 TYK2 IFNL2 MFAP5-MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20220510%WP3301%HOMO SAPIENS MFAP5-mediated ovarian cancer cell motility and invasiveness RYR3 ITGAV TNNC1 PRKCQ DKFZp434N101 CREB1 ITGB3 MAPK3 MFAP5 JUN DKFZp666O0110 MAPK1 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20220510%WP399%HOMO SAPIENS Wnt signaling pathway and pluripotency LRP5 NKD1 NKD2 FOSL1 FZD10 DVL1 WNT10B CTNNB1 DVL2 TCF7L1 MAPK9 LRRK2 WNT16 PAFAH1B1 WNT1 FZD3 WNT3A CCND1 WNT11 FZD1 PRKCI FZD2 FZD5 PRKCB FZD4 CCND2 EP300 FZD7 FZD9 MMP7 FZD8 CD44 PRKCZ NFYA ESRRB MAP3K7 LDLR MAP2K4 PPP2R2A JUN CTNND1 WNT4 PRKCQ PPP2R1A CCND3 MAPK10 PPP2R1B PPP2CA GSK3B PRKCA ARHA DKFZp586H0919 APC AXIN1 PRKCH AXIN2 NR1C2 WNT5B PRKCE WNT3 TCF7L2 WNT10A WNT2B WNT9B LRP6 DKFZp586M1622 SOX2 WNT7B WNT7A PPP2R5E FRAT1 POU5F1 PPP2R5C FOXD3 ZBTB33 FBXW2 PPM1J CSNK1E PTPA CREBBP PPP2R3B PPP2R3A CTBP2 PRKD1 PPP2R2C PPP2R2B CTBP1 MYC NLK TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20220510%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis PPARG DDIT3 GATA3 GATA2 EGR2 CEBPG CEBPA KLF15 CEBPB KLF2 KLF5 CEBPD 22Q11.2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP4657%HOMO SAPIENS 22q11.2 copy number variation syndrome HEL25 GP9 GBX2 GP1BA CRKL RORC FGFR2 GLUD1 CDH15 FOXC2 FOXC1 CDC42 NKX2-5 PITX2 TBX1 SHOC2 PAK4 HAND2 FOXA2 FGF5A PLK1 SLC2A4 HIRA HIRIP3 HEL-S-80p TSKS EMC10 ZDHHC8 SERPIND1 RCC1 GSC2 SHH HES1 C22orf39 THAP7 TSSK2 ASF1A RTL10 NPRL2 TRMT2A PIK4CA TXNRD2 ESS2 PRODH KLHL22 GP5 HIST1H4J UFD1L SLC25A1 LRRC74B SEPT8 MRPL40 DGCR6L SCARF2 TNPO1 DGCR2 GP1BB BCL2 C16orf35 RTN4R SLC7A4 GNB1L RTN4 DEPDC5 PARK2 ARVCF RANBP1 ALDH1A2 ALDH4A1 P2RX6 ZNF74 RAN SEPT5 RBX1 MED15 SREBF2 NCOR1 POLR2A CLDN1 CLDN5 CLDN3 RELN CLTCL1 CYP26A1 DROSHA DGCR8 CYP26B1 FGFR1 VWF CDC45 PAX3 FGF8 ACTA2 EGFR SNAP29 CYP26C1 RAF1 HDAC3 DRD2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20220510%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias STAT5B PTHLH SPP1 MEF2C FGFR3 ALPL PLAT IGF2 ENPP1 ACAN IGF1R STAT1 SCIN FGF6A TGFB1 SOX9 VEGFA CDKN1C CHST11 CAB39 FRZB SOX6 IGF1 RUNX2 BMP6 PTCH1 BMPR1A GH1 GLI3 CALM3 CALM2 FGFR1 GHR THRA SOX5 MMP9 IHH ADAMTS5 KIF3A PTH1R FGF2 HMGCS1 ADAMTS4 COL10A1 NKX3-2 DDR2 CST5 TIMP3 COL2A1 MGP HDAC4 RUNX3 PTH BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20220510%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL GPT OTC F7 NAGS HEL-S-20 F10 GLS2 ASS ARG1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20220510%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS1 PCYT1B CEPT1 PTDSS2 hCG_16873 PCYT2 PISD ETNK1 PEMT SGPL1 CHPT1 CHKA ALSTROM SYNDROME%WIKIPATHWAYS_20220510%WP5202%HOMO SAPIENS Alstrom syndrome SMO ACTN4 IFT74 PTCH1 IFT27 BLOC1S4 VCPIP1 BLOC1S6 BLOC1S1 GPRASP2 SNAPIN PIFO TFDP2 DTNBP1 HSPB11 RFX2 RFX3 RFX1 RABL2B TUBG1 RILPL1 MYO5B ALMS1 STX5A IFT172 CEP19 E2F4 HEL-S-70 GPR161 IFT81 KIAA1569 DNM3 PRO-SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20220510%WP5182%HOMO SAPIENS Pro-survival signaling of neuroprotectin D1 RIPK3 hCG_16983 CASP9 BIRC3 TNF-alpha CASP3 RIPK1 FADD TRAF2 TRADD TNFRSF1A CYCS BAX PARKIN-UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20220510%WP2359%HOMO SAPIENS Parkin-ubiquitin proteasomal system pathway PSMC4 PSMC1 HEL-S-89n UBE1 TUBA2 hCG_16983 TUBA8 TUBAL3 UBE2L6 UBE2J2 PARK2 UBE2J1 UBE2L3 SNCA UBE2G1 UBE2G2 SNCAIP SEPT5 RNF19A FBXW7 HSPA14 GPR37 HSPA4 STUB1 CCNE1 SIAH2 SIAH1 PSMD10 PSMD12 PSMD11 HEL-S-72p HEL-S-91n PSMD13 PSMD9 PSMD6 PSMD7 PSMD4 CASK PSMD5 TUBA1C TUBA1B PSMD2 TUBA1A PSMD3 PSMD1 TUBB TUBB2A TUBA3E TUBB4B TUBB4A TUBB8 HSPA1B TUBB6 TUBB1 HSPA2 TUBA4A PSMC6 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20220510%WP5195%HOMO SAPIENS Disorders in ketolysis ACAT2 ACAT1 OXCT1 HMGCS1 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20220510%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LIPC LPL APOA4 LDLR APOA2 VLDLR APOE SCARB1 APOA1 PLTP TRANSLATION FACTORS%WIKIPATHWAYS_20220510%WP107%HOMO SAPIENS Translation factors EEF2K EIF2S1 EIF4H EEF1A1 EIF4A2 EIF4EBP2 EIF2AK1 EIF3S3 EIF2AK2 EIF4G1 EIF3F EIF3D EIF4B EIF1AX EIF3S1 GSPT2 SUI1 EEF1B2 EIF5 EIF4EBP3 EIF3S2 EIF2B1 EIF2S3 PAIP1 EIF3S9 EIF2B3 EIF3S8 EIF4E CLUH EIF3G EIF1AY EIF3E EEF1G EIF3A EIF2S2 EIF6 EIF2B2 EEF1D EIF5A EEF1A2 EIF4A1 ETF1 EIF2B5 EIF5B PABPC1 DKFZp781H1925 EIF4EBP1 BIOTIN METABOLISM, INCLUDING IMDS%WIKIPATHWAYS_20220510%WP5031%HOMO SAPIENS Biotin metabolism, including IMDs PCCA ACACB PCCB BTD HLCS PC DKFZp686B20267 ACACA GLUCOSE METABOLISM IN TRIPLE-NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20220510%WP5211%HOMO SAPIENS Glucose metabolism in triple-negative breast cancer cells PFKP HEL-S-30 HEL-S-133P PPM2C TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20220510%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma CDKN1A ARNT2 PRCC TFEB DVL2 EGLN1 CTSK VHL BIRC7 TGFB1 TCEB1 FH EP300 CREBBP SFPQ VEGFA EGLN3 RBX1 CADM2 TGFA COL21A1 SETD2 EGLN2 HIF1A DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20220510%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 DDX1 DROSHA DGCR8 MRE11A ATM NBN H19 ACTION RB-E2F1 SIGNALING AND CDK-BETA-CATENIN ACTIVITY%WIKIPATHWAYS_20220510%WP3969%HOMO SAPIENS H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity CCND1 MED1 CDK8 CSRP2 CDK4 PMAIP1 CTNNB1 MACROH2A1 RB1 SOX4 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20220510%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH3 ALKBH2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20220510%WP4571%HOMO SAPIENS Urea cycle and related diseases ASL OTC SLC25A15 NAGS SLC25A13 GLS2 ASS ARG1 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP47%HOMO SAPIENS Hedgehog signaling pathway SAP18 SUFU KIF7 PTCH1 SHH GLI3 IHH ADRBK1 DHH SIN3A SMO PTCH2 MAMMARY GLAND DEVELOPMENT PATHWAY - INVOLUTION (STAGE 4 OF 4)%WIKIPATHWAYS_20220510%WP2815%HOMO SAPIENS Mammary gland development pathway - Involution (Stage 4 of 4) STAT3 CHI3L1 MMP9 SOCS3 MYC IL6ST BAX RAS AND BRADYKININ PATHWAYS IN COVID-19%WIKIPATHWAYS_20220510%WP4969%HOMO SAPIENS RAS and bradykinin pathways in COVID-19 ARHA NFKB1 KLNA1 PRKG1 IL1B ROCK1 IL1A TNF-alpha MAPK1 REN CYP3A4 ACE2 KLKB1 CPN1 SERPING1 AGTR1 AGTR2 SERPINE1 CYP24A1 BDKRB2 NR1i1 BDKRB1 KNG1 MALIGNANT PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20220510%WP5087%HOMO SAPIENS Malignant pleural mesothelioma KITLG FZD10 FGF23 FGF22 RASSF7 WNT16 ACTA1 RPS6KA5 FGF1B FGF1A WNT11 FZD1 FZD2 FGFR4 FZD5 FGFR3 FGFR2 FZD7 CCND2 FZD9 PIK3CD FZD8 BMI1 IGF2 CDH9 LIN28B CDH8 AMOT ITGA1 CDH4 FGF7B CDH10 CDH12 MAP2K5 CDH15 TEAD4 MMP14 FGF7A MOB1A CDH17 CDH18 EIF4B VGLL4 LATS1 LATS2 CDH19 CDH24 CXCL5 MAP4K1 TEAD2 FGF6B TEAD3 FGF6A AJUBA PAK1 MDM4 PAK6 CSNK1A1 VEGFB VEGFC VEGFA MAPK3 PAK4 EGF DKFZp666O0110 FGF5C MAPK7 BRCA1 FGF5B WWTR1 FGF5A MEF2D BARD1 MAP3K2 MAD2L1 APC RB1CC1 MDM2 IGF1 WNT5B ITGA4 SLC3A2 ITGA2 WNT3 WNT10A DKK1 WNT2B LRP6 CYCS WNT7B WNT7A EZH2 CSF3 LAMB2 CSF2 CSF1 LAMA4 HCFC1 CXCL1 LAMC1 IL10 CHD8 FRAT2 COL4A2 SOX17 COL4A1 IL6 SOST CER1 CSNK2A3 CSNK2A2 MCL1 KREMEN1 ITGB1 CSNK1E DKFZp451O0517 DKK4 SENP2 DKK2 SFRP4 SFRP5 MMP2 CSNK2B ROR1 ROR2 ATF3 CTBP1 MAPK8 MYC EIF4EBP1 CXXC4 ANGPT4 PORCN ANGPT2 WIF1 ANGPT1 RYK FOSL1 INSR RASSF1 CTNNB1 NOTUM CSNK1A1L MAP3K11 OGT BBC3 NLRP3 EPHA2 PRB1 TGFA TRAF2 SETD2 DKFZp451J023 CD47 MMP3 PPARGC1A JUN FLT3LG CTHRC1 PDGFD UHRF1 PDGFC WNT4 MAP3K6 MAP3K10 SPARC CCND3 DEPTOR NTF5 COL4A4 RASSF2 RASSF3 VEGFD COL4A3 RASSF4 MAD1L1 BAP1 COL4A6 PRSS23 CIT COL4A5 DKFZp686A1782 YY1 FGF8A DSC3 MGC34647 SHC1 BAG2 FOXM1 MDK WDR5 EFNA4 MOBKL1A ASXL1 EED BDNF EFNA1 EFNA3 EIF4G1 HEL-S-1 EFNA2 PTEN DKFZp586M1622 FLT3 RBBP4 SUZ12 CDH6 LAMC2 CDH2 MMP9 TTI1 SLC7A5 IL1B LAMA5 LAMA1 LAMA3 MKNK1 HBEGF ACTA2 NTRK2 CDKN2A EGFR MCU LAMB3 LAMB1 CTBP2 INS CTNNA1 WNT10B DVL1 DVL2 TCF7L1 AREG WNT1 BTC FZD3 DDIT3 WNT3A CCND1 SFRP1 TERT CD44 ITGA6 HGF JAK1 LGALS9 IGF1R STAT1 FOXO1 IDO1 TGFB1 CCNE1 HMGB1 CDK4 SP1 ITGB4 EFNA5 FGF13 HIF1A CTGF KDR MAP4K2 KMT2C SELE DKFZp781N011 CDK2 ACTG2 CREB1 ULK2 ULK1 MAX HMGN1 CDKN1A MAPKAPK2 RNF2 SRC HEL-S-31 MINK1 STK38L TNIK NF2 PLCB4 CCL2 BAX LRP5 MAP2K1 MAPK14 NFKB1 MAPK9 PIK3CA BCL2 MAPK1 CDH11 ATF2 raptor CSF1R PRKAG1 FLT1 PRKAG2 FGF8C PRKAG3 KIT ACTG1 RPS6KA3 PS1TP5BP1 CDH16 RPS6KA1 AKT3 MLST8 HRAS CSNK2A1 WWC1 MAP2K4 MAP3K5 MAP2K3 PRKAB2 RPS6 NGFR TSC2 CCL5 CCL4 TSC1 MAP2K6 MAPK10 PRKAB1 CXCL10 NGF AKT1S1 NTF3 SOS1 KIF23 ITGAV GSK3B DKFZp586H0919 NTRK1 AXIN1 PRKAA1 SETD5 PRKAA2 CTNNA3 BAK1 CTNNA2 GABPA TCF7L2 ATM MTOR SETDB1 TNNT1 LIMD1 RPS6KB1 RHEB RPS6KB2 GRB2 FGFR1 MAP3K1 FRAT1 FGF4B FGF4A PIGF FGF2 ITGB3 FLT4 FGF8 CXCL12 PDGFRA MAP2K2 RAF1 PDGFA FABP4 CDK7 IL-4 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP395%HOMO SAPIENS IL-4 signaling pathway PIK3R2 PIK3R1 GATA3 STAT5B STAT3 SOS1 CHUK PTPN11 FOS MAPK14 NFKB1 IKBKB RELA PIK3CA SHC1 IL2RG MAPK1 STAT6 SOCS5 ATF2 BAD EP300 PIK3CD NFKBIA MAPK11 RPS6KB1 JAK1 GRB2 IRS1 INPP5D FLNA SOCS1 STAT1 JAK3 IL4 TYK2 GAB2 NFIL3 FES HRH1 MAPK3 BIRC5 CBL PTPN6 CEBPA SOCS3 CEBPB VITAMIN D METABOLISM%WIKIPATHWAYS_20220510%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27B1 CYP2R1 DHCR7 GC RXRA CYP24A1 CYP27A1 PTH RXRB NR1i1 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20220510%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA5 LDLR ANGPTL4 PLTP LIPC SEL1L LPL APOA4 ANGPTL3 LMF1 GPIHBP1 APOA2 APOA1 ANGPTL8 LEPTIN-INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20220510%WP3935%HOMO SAPIENS Leptin-insulin signaling overlap STAT3 IRS1 INS INSR PDPK1 SOCS1 LEPR DGKZ SOCS2 IRS4 SOCS3 LEP PIK3R3 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20220510%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 FOLATE-ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20220510%WP1589%HOMO SAPIENS Folate-alcohol and cancer pathway hypotheses MTR DKFZp727E011 ADH5 CREB1 CYP2E1 CEBPB HEL-S-53e NON-GENOMIC ACTIONS OF 1,25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20220510%WP4341%HOMO SAPIENS Non-genomic actions of 1,25 dihydroxyvitamin D3 MAPK14 NFKB1 IKBKB MAPK9 IFI44L NOD2 TNF-alpha MAPK1 PLCE1 PRKCB ISG15 CYP24A1 DKFZp686M02159 TNFRSF1A PRKCZ JAK1 HRAS STAT1 STAT2 TYK2 RXRB JUN TLR8 TLR4 IF1AB4 NFKB2 PRKCQ SP3 SP1 MAPK3 MAPK7 IL8 CYP27B1 PRKCA MED1 CAMK2D PRKCH CAMK2A PRKCE RXRG PLCB2 NRAS CAMK2G MAPK13 IFI27L2 MAPK11 RSAD2 OAS2 KRAS CD40 PLCB1 PLCG2 RELB IL6 PLCB3 PLCB4 CAMP CCL2 DEFB4B RXRA IF2F CD40LG MAPK8 NR1i1 LNCRNA-MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20220510%WP3672%HOMO SAPIENS lncRNA-mediated mechanisms of therapeutic resistance CDKN1A BCL2L1 ABCB1 HIF1A HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20220510%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway HEL-S-133P PRKAA1 EGLN1 ACACA ACACB RPS6 PDHA1 SLC11A2 PRKAG1 KEAP1 VEGFA PDHA2 PRKAB1 HIF1A NFE2L2 MELANOMA%WIKIPATHWAYS_20220510%WP4685%HOMO SAPIENS Melanoma PIK3R2 PIK3R1 MAP2K1 BRAF FOS MITF-C PIK3CA MAPK1 CCND1 PIK3CD ERBB4 KIT RAC1 AKT3 HRAS CDK6 SHC2 GADD45B PAK1 CDK4 MAPK3 ARAF RB1 CALML6 KDR SOS1 SOS2 CALML3 CALML4 MDM2 DDB2 GADD45A BAK1 GADD45G NRAS POLK NF1 BAD CREB1 PTEN PREX2 KRAS CDKN1A GRB2 CALM3 CALM2 HEL114 E2F2 E2F3 CDKN2A MAP2K2 GRM3 RAF1 PIK3R3 BAX LAMTOR3 DNA DAMAGE RESPONSE (ONLY ATM DEPENDENT)%WIKIPATHWAYS_20220510%WP710%HOMO SAPIENS DNA damage response (only ATM dependent) PIK3R2 PIK3R1 PIK3R5 FOSL1 INSR NFKB1 DVL1 WNT10B CTNNB1 DVL2 TCF7L1 MAPK9 TNFSF6 PIK3CA WNT16 WNT1 TP73 BCL2 MAPK1 WNT3A CCND1 WNT11 BBC3 CCND2 PIK3CD PIK3C2G PIK3C2A PIK3C2B RAC3 RAC1 AKT3 MAP3K7 HRAS LDLR DKFZp564M2422 JUN CDC42 TGFB1 PCK2 WNT4 NFKB2 HMGB1 PMAIP1 CCND3 MAPK10 SOS1 SOS2 GSK3B CDKN1B ARHA DKFZp586H0919 APC FOXO3A AXIN1 MDM2 WNT5B SHC1 BAK1 WNT3 TCF7L2 BCL6 NRAS SMAD4 WNT10A G6PC1 WNT2B BAD BCL2L11 ATM RBL2 PTEN DKFZp586M1622 MLKL KRAS CDKN1A WNT7B GRB2 WNT7A IRS1 PPP2R5E MAP3K1 FRAT1 PPP2R5C CCNG2 BIK CDKN2A PIK3R4 MAPK8 MYC ERBB2 PIK3R3 BAX MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20220510%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDKN1A RAD52 CCND1 CCNE1 CDKN1B H2AX CREB1 ATM CCND3 CDK6 MYC QUERCETIN AND NF-KB / AP-1 INDUCED APOPTOSIS%WIKIPATHWAYS_20220510%WP2435%HOMO SAPIENS Quercetin and Nf-kB / AP-1 induced apoptosis MAFK FOS NFKB1 ACOX2 IKBKB JUN PTGS2 hCG_1991559 KEAP1 VEGFA NFKBIA CYP2A6 COX1 NFE2L2 VITAMIN B6-DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20220510%WP4228%HOMO SAPIENS Vitamin B6-dependent and responsive disorders PIGV AASS HEL-S-302 ALPI ALDH7A1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20220510%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV STX1A CAMK2D CAMK2A ARC RYR2 MAPK1 CAMK2G HOMER1 YWHAG GRIN2B GRIN1 RPH3A NLGN1 NLGN3 NLGN2 NRXN1 NRXN3 NRXN2 DLGAP1 DLG2 SHANK1 CYFIP1 FMR1 MAPK3 DKFZp686A1195 SYNGAP1 HOST-PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES - MAPK SIGNALING%WIKIPATHWAYS_20220510%WP4877%HOMO SAPIENS Host-pathogen interaction of human coronaviruses - MAPK signaling IFI27 MAP2K1 JUNB FOS MAPK14 MAPK9 BCL2 MAP3K11 MAPK1 DDIT3 ATF2 MAPK13 IFITM1 MAPK11 DKFZp686M02159 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K1 MAP2K4 IFITM2 MAP2K3 BST2 JUN EIF4E MAP2K2 MAP3K10 RAF1 MAPK3 IFITM3 MAP2K6 MAPK10 MAPK8 ANTIVIRAL AND ANTI-INFLAMMATORY EFFECTS OF NRF2 ON SARS-COV-2 PATHWAY%WIKIPATHWAYS_20220510%WP5113%HOMO SAPIENS Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway IL8 IL12A CHUK SLC7A11 NFKB1 GUCY1B1 IKBKB RELA TNF-alpha IKBKG GUCY1A2 NFKBIA TMPRSS2 MMP3 HMOX1 PRKG2 IL1B IL6 ACE2 IRF3 CCL2 GCLC KEAP1 RXRA NQO1 GCLM NFE2L2 MIR-509-3P ALTERATION OF YAP1/ECM AXIS%WIKIPATHWAYS_20220510%WP3967%HOMO SAPIENS miR-509-3p alteration of YAP1/ECM axis TEAD4 THBS2 EDNRA COL3A1 COL1A1 GPC6 PBX3 TEAD2 TEAD3 DKFZp451O0517 SPARC TWIST1 SNAI2 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20220510%WP4147%HOMO SAPIENS PTF1A related regulatory pathway FGF5A PROX1 PDX1 HES1 KAT2B NOTCH1 RBPJL CTNNB1 PTF1A NKX6-1 RBPJ FOCAL ADHESION: PI3K-AKT-MTOR-SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP3932%HOMO SAPIENS Focal adhesion: PI3K-Akt-mTOR-signaling pathway PIK3R2 PIK3R1 XB PIK3R5 KITLG FGF22 GNG12 FGF1B FGF1A FGFR4 FGFR3 GNG2 FGFR2 PIK3CD PIK3C2A PIK3C2B COMP FGF7B FGF7A EIF4B IL2RB FGF6B FGF6A VEGFB VEGFC IL2RA VEGFA MAPK3 IL7R EGF DKFZp666O0110 FGF5C FGF5B FGF5A ITGB8 MDM2 ITGB7 IGF1 CASP9 ITGA4 ITGA2 ACACA STK11 ITGA7 NOS2 BAD ITGB5 CSF3 IRS1 LAMB2 CSF1 LAMA4 LAMC1 THBS2 THBS1 COL3A1 IL6R COL1A2 COL4A2 COL4A1 COL5A3 COL5A2 ITGB6 ITGB1 ATF4 GYS2 EIF4EBP1 GYS1 ANGPT4 ANGPT2 ANGPT1 INSR CDC37 EPHA2 PPARGC1A HEL-S-125m TCL1B TCL1A LPAR3 PDGFD PDGFC GNG11 GNG13 PRL GNGT2 hCG_1994888 OSMR PHLPP2 PHLPP1 ATF6B RELN COL4A4 OSM CDKN1B VEGFD CSHL1 COL4A6 GHB3 CSF3R FGF8A TNC TNR PRLR EIF4E1B EFNA4 CHAD EFNA1 EFNA3 EFNA2 GNB2 GNB4 GNB3 PTEN EDG2 LAMC2 EDG4 GHR PPP2R5E VWF PPP2R5B PPP2R5A PPP2R5C IL3RA LAMA5 LAMA1 LAMA3 MGC17330 THBS4 PELO THBS3 HIF3A GNG3 COL2A1 PFKFB1 GNG5 PFKFB4 GNG4 PPP2R3C EIF4E RAB10 GNG7 GNG8 EGFR LAMB3 LAMB1 RAB8A PPP2R3A EPOR PPP2R2C PPP2R2B COL11A2 PPP2R2D INS RAB2 RAB14 ITGA6 HGF JAK1 IFNAR2 IF1AA5 IF1DA1 IGF1R JAK3 FOXO1 IL2 IFNAR1 PPP2R1A ITGB4 EFNA5 FGF13 PPP2R5D HIF1A HSP90AB1 PPP2R1B CRTC2 KDR STRADA SLC2A2 CAB39 CREB3L3 SLC2A3 CREB3L4 SLC2A4 COL1A1 DKFZp686N2325 IL2RG RAB11B CREB3 CREB1 DDIT4 ULK1 ITGAE CREB5 CDKN1A KPG_010 LPAR4 MAP2K1 GNGT1 IKBKB SPP1 PIK3CA GNB1 MAPK1 IKBKG ATF2 raptor CSF1R FOXA1 FLT1 FGF8C KIT AKT3 MLST8 HRAS IBSP RPS6 NGFR TSC2 TSC1 ELAVL1 NGF AKT1S1 PPP2CA ITGAX SOS1 ITGAV GSK3B FOXO3A PDPK1 PRKAA1 PRKAA2 PFKFB2 NRAS CHRM2 CHRM1 MTOR RPS6KB1 RHEB RPS6KB2 KRAS GRB2 FGFR1 F2R FGF4B FGF4A EPO VTN FGF2 ITGB3 ITGA2B FGF4C FLT4 FGF8 PDGFRA MAP2K2 RAF1 IRS4 PIK3R4 PDGFA DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20220510%WP5178%HOMO SAPIENS Disorders of fructose metabolism GLYCTK G6PC1 SLC2A2 PFKL ALDOB SORD FBP1 HEL-S-49 SLC5A1 HEL-S-53e BLADDER CANCER%WIKIPATHWAYS_20220510%WP2828%HOMO SAPIENS Bladder cancer PIK3R2 IL8 PIK3R1 MAP2K1 BRAF RASSF1 MDM2 TYMP MAPK1 RPS6KA5 NRAS CCND1 FGFR3 KRAS CDKN1A MMP9 THBS1 HRAS SRC HBEGF CDKN2A DAPK2 EGFR MAP2K2 UPK3A MMP2 CDK4 RAF1 VEGFA ARAF EGF RB1 MYC ERBB2 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS)%WIKIPATHWAYS_20220510%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis (FSGS) LRP5 HEL113 CTNNB1 WNT1 PLCE1 CTSL CD80 WT1 IRF6 TGFB1 TLR4 FAT1 PCNA CLDN1 ITGB4 DKFZp666O0110 DAG1 CDKN1C COL4A4 ITGAV CDKN1B COL4A3 CR1 COL4A5 HEL-S-28 PAX2 ACTN4 YWHAQ DKK1 MYH9 TLN1 DKFZp434N101 LRP6 PARVA CDKN1A CDH2 LAMB2 SCARB2 SMARCAL1 HEL114 CD151 PTPRO VTN ITGB3 SYNPO LAMA5 TRPC6 AGRN PLAUR CD2AP LMX1B FYN MYO1E MME INF2 ITGB1 NPHS1 NPHS2 MKI67 NCK1 KIRREL3 NOTCH1 KIRREL2 LIMS1 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20220510%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer JAK1 STAT3 EGFR MAPK3 MAPK1 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20220510%WP4220%HOMO SAPIENS Neurotransmitter disorders MAOA DBH DDC TH FAMILIAL PARTIAL LIPODYSTROPHY (FPLD)%WIKIPATHWAYS_20220510%WP5102%HOMO SAPIENS Familial partial lipodystrophy (FPLD) PPARG GATA3 STAT5B PLIN1 GATA2 INS MGLL NR1C1 MAPK9 PIK3CA KLF2 KLF5 BANF1 LPL ZMPSTE24 CIDEA FNTA LMNA PNPLA2 KLF9 LMNB2 PRRX1 CIDEC CEBPA FABP4 MIRNA BIOGENESIS%WIKIPATHWAYS_20220510%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DICER1 RAN DROSHA TARBP2 DGCR8 NAD+ BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20220510%WP3645%HOMO SAPIENS NAD+ biosynthetic pathways PARP1 PARP2 SIRT4 SIRT5 SIRT1 TDO2 NMNAT1 HEL-S-90n SIRT7 PBEF1 SIRT2 SIRT3 NAPRT NADSYN1 IDO1 SIRT6 PARP4 TNKS BST1 TNKS2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20220510%WP4970%HOMO SAPIENS Galanin receptor pathway CDKN1A PPARG CDKN1C INS CDKN1B KRT19 FOS CRP SLC2A4 PPARGC1A UCP1 POMC TFAP2A IL6 DKFZp451O0517 CREB1 BCL2L11 VEGFA VAMP2 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20220510%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EFCAB3 PBRM1 STAT3 ACLY TOX2 HEL-S-30 SDSL PGBD5 LDHD HEL-S-133P HEL-S-68p SSPN HEL-S-17 PFKM HEL-S-162eP HEL-S-49 GRB10 HEL-S-281 BHLHE41 PHGDH raptor EP300 FLT1 SETD2 DKFZp667A016 ENPP3 SQSTM1 MLST8 SHMT1 HEL-S-51e VHL ACACB TGFB1 TSC2 PKLR TSC1 VEGFA HEL-S-32 FASN KSR1 HIF1A DEPTOR AKT1S1 PFKP PSPH KDR HEL-S-87p PSAT1 BAP1 KCNJ2 ACACA ME1 PGM2 MTOR PTEN RHEB ENO2 ENO3 HK2 HK3 PFKL ALDOC ALDOB CEP290 PDGFRA EGFR CREBBP CAMK1 PLOD2 KDM5C BASE EXCISION REPAIR%WIKIPATHWAYS_20220510%WP4752%HOMO SAPIENS Base excision repair FEN1 MPG PNKP OGG1 UNG NTHL1 MUTYH MBD4 TDG APEX2 NEIL3 POLD3 NEIL2 POLD4 POLD2 APEX1 SMUG1 PARP1 LIG3 POLE PARP2 POLE2 HMGB1 PCNA LIG1 POLE4 POLE3 DNA REPAIR PATHWAYS, FULL NETWORK%WIKIPATHWAYS_20220510%WP4946%HOMO SAPIENS DNA repair pathways, full network CETN2 XPA FEN1 MPG XPC GTF2H2C_2 PNKP OGG1 GTF2H2 UNG GTF2H3 NTHL1 GTF2H5 MUTYH CUL4A MBD4 ERCC3 APEX2 ERCC1 NEIL3 ERCC5 NEIL2 REV1 BRIP1 NHEJ1 FANCM FANCL FANCA FANCC APEX1 DKFZp566H033 FANCB FANCE PALB2 FANCF WDR48 POLI RAD51C FAN1 RAP1A FAAP24 LIG3 CENPX POLM PARP2 CENPS MSH3 HMGB1 PCNA BRCA1 MSH6 PRKDC TDG POLK H2AX SMUG1 ERCC2 POLE RPA3 POLE2 MNAT1 RFC3 RFC4 USP1 MSH2 DKFZp686J1569 LIG1 RFC2 POLE4 POLE3 RAD51 CHEK1 ATR RBX1 PARP1 XRCC5 RFC1 CCNH FANCD2 MGMT DDB2 CUL4B POLD3 RAD52 POLD4 RAD50 POLD2 RPA1 TERF2 MRE11A ATM NBN BRCA2 FANCG RAD54B WRN DDB1 CDK7 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20220510%WP4784%HOMO SAPIENS Proteoglycan biosynthesis XYLT1 CSGALNACT1 SLC35B2 SLC26A2 CANT1 CHST14 B3GAT3 XYLT2 B3GALT6 CHSY1 IMPAD1 EXT1 EXT2 PAPSS2 CHST3 SARS-COV-2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20220510%WP5065%HOMO SAPIENS SARS-CoV-2 altering angiogenesis via NRP1 FURIN KDR VEGFA NRP1 ACE2 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20220510%WP26%HOMO SAPIENS S1P receptor signal transduction EDG5 SMPD2 SPHK2 S1PR5 SPHK1 AKT3 S1PR1 PLCB1 MAPK1 PLCB2 GNAI1 PLCB3 S1PR3 GNAI3 MAPK6 MAPK4 MAPK3 PIK3C2B DKFZp686M02159 MAPK7 ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP138%HOMO SAPIENS Androgen receptor signaling pathway PIK3R2 PIK3R1 STAT3 CTNNB1 PPAP2A HTATIP HEL-S-67p UBE3A CCND1 RAN EP300 RAD9A KDM1A RAC1 SIRT1 PIAS1 HEL-S-99n STUB1 SIN3A ROCK1 ROCK2 FOXO1 NCOR1 JUN EFCAB6 ZMIZ1 PP2150 HEL32 CDC42 KAT7 CCNE1 ZNF318 FKBP4 PAK6 NR0B2 ZNF278 RNF6 RNF4 PIAS2 PSMC3IP BAG1 SP1 UBE2I RB1 ETV5 DKFZp666O0110 BRCA1 GSK3B ARHA TGFB1I1 LIMK2 TGIF1 MDM2 FHL2 RELA RUNX2 NCOA1 SMAD4 SUMO1 SMARCE1 RLN1 CREB1 KLK3 PTEN NR2C2 CDKN1A FLNA KAT2B NCOR2 SRC RHOB BMF EGFR CREBBP CARM1 HDAC1 MAMMARY GLAND DEVELOPMENT PATHWAY - PREGNANCY AND LACTATION (STAGE 3 OF 4)%WIKIPATHWAYS_20220510%WP2817%HOMO SAPIENS Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) CHUK CSN2 YY1 PRLR PGR NR3C1 ESR2 CCND1 ERBB4 TNFSF11 TNFRSF11A ERBB3 EIF4E BCL2L1 EGFR PRL hCG_20925 PNCK USF2 CEBPA PTPN1 GJB2 CEBPB MYC ERBB2 GAL ELF5 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20220510%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family GFI1 RORA IL12B ZBTB16 GATA3 IL12A AREG TNF-alpha IF2B1 AHR TBX21 IL33 IL23A IL9 IL18 ID2 IL25 TOX IL17A IL15 IL13 IL1B IL4 HNF1A IL6 IL5 NFIL3 IL7 TSLP ATL1 IF2F MODULATION OF PI3K-AKT-MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20220510%WP5192%HOMO SAPIENS Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids hCG_2045882 SPHK2 IGF1R NFKB1 S1PR1 PIK3CA CERS1 S1PR3 ASAH2 CERK TSC1 MTOR HIF1A NIPBL ROLE IN DNA DAMAGE - CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20220510%WP5119%HOMO SAPIENS NIPBL role in DNA damage - Cornelia de Lange syndrome MDC1 ATR RNF8 H2AX ATM CBX3 NIPBL FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20220510%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA5 FAS GCK ACSS1 PDIA2 LDLR MTTP PLTP LIPC SEL1L LPL APOA4 LMF1 GPIHBP1 GCKR DGAT2 APOA2 APOA1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20220510%WP357%HOMO SAPIENS Fatty acid biosynthesis PECR MECR ACLY ECHDC1 ECHDC2 ACACA ACSL1 ACACB ACSS2 FACL4 ACSL5 DECR1 ECHS1 ACSL3 FASN PC SCD KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20220510%WP4742%HOMO SAPIENS Ketogenesis and ketolysis ACAT1 SLC25A20 OXCT1 UCP2 CPT2 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20220510%WP3927%HOMO SAPIENS BMP signaling in eyelid development FGF5A MAP3K1 MAPK9 FOXC2 JUN FOXC1 SMAD4 SMAD1 PITX2 INHBB EGFR SFRP1 DKK2 SHH FGFR2 NOTCH1 BMP4 DKFZp781O1323 MAPK3 TGFA HOST-PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES - INTERFERON INDUCTION%WIKIPATHWAYS_20220510%WP4880%HOMO SAPIENS Host-pathogen interaction of human coronaviruses - interferon induction MYD88 CHUK FOS MAPK14 NFKB1 IKBKB IKBKG EIF2AK2 NFKBIA IFIH1 TBK1 IKBKE OAS2 JAK1 OAS3 TLR7 IFNAR2 OAS1 MAP3K7 STAT1 DDX58 STAT2 JUN TYK2 TICAM1 TRAF6 MAVS IRF3 TRAF3 IRF9 IFNAR1 RIPK1 MAPK8 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20220510%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells HEL-S-102 STAT3 KDR CD63 MMP9 IGF1 SPP1 GATA4 IL6 TLR4 EGFR CD81 HEL-S-44 BIRC5 EGF PTEN ETS2 FOXA2 PATHWAY%WIKIPATHWAYS_20220510%WP5066%HOMO SAPIENS FOXA2 pathway PPARGC1B IRS1 INS SLC27A5 MLXIPL FOXO1 APOB MTTP SLCO1B1 GSTM2 ACACA ABCC3 ABCC2 FOXA1 FASN FOXA2 SLEEP REGULATION%WIKIPATHWAYS_20220510%WP3591%HOMO SAPIENS Sleep regulation DRD3 UTS2 HCRTR2 MRGPRX2 FOS HCRTR1 NPAS2 CHRNB2 AHCY BTBD9 STAR OXT ADA HEL-S-2 HTR2A NLGN1 IL18 TH NPY2R OXTR NPS SLC29A1 CRH DLAT PER3 MTNR1B ADORA2A IL6 GHRH PTGDR PTGDS GHRL UTS2R CACNA1I DRD1 DRD2 PRION DISEASE PATHWAY%WIKIPATHWAYS_20220510%WP3995%HOMO SAPIENS Prion disease pathway STAT3 HEL-S-89n NCAM1 BCL11A HEL-S-269 NFKB1 BCL2 MAPK1 RAD21 IRF4 RFX5 PRNP CASP3 MEF2C TBP POU2F2 EP300 CREB1 BATF CTCF FGFR1 PAX5 SPI1 HEL-S-125m FYN CHD2 SMC3 RXRA MAPK3 CASP12 DKFZp666O0110 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20220510%WP134%HOMO SAPIENS Pentose phosphate metabolism RPE HEL107 RPIA HEL-S-304 INTERLEUKIN-1 (IL-1) STRUCTURAL PATHWAY%WIKIPATHWAYS_20220510%WP2637%HOMO SAPIENS Interleukin-1 (IL-1) structural pathway TAB3 MAP2K1 MYD88 CHUK NFKBIB IL1R1 FOS MAPK14 NFKB1 SAFB IKBKB RELA MAPK9 MBP TANK MAPK1 RPS6KA5 ATF2 NFKBIA MAPK11 MAPKAPK2 MAP3K1 MAP3K8 MAP3K7 MAP2K4 MAP2K3 IRAK4 IL1A MKNK1 TRAF6 IRAK2 IRF7 EIF4E IRAK1 MAP2K2 MAPK3 MAP2K6 DKFZp686J04131 MAPK10 MAPK8 MAP3K7IP1 MYC 15Q13.3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP4942%HOMO SAPIENS 15q13.3 copy number variation syndrome FAN1 GPR75 KAT2B GOLGA8R KLF13 OTUD7A CHRFAM7A GOLGA8O TRPM1 GOLGA8H FYN CCL5 FANCD2 CREBBP GRM6 MTMR10 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20220510%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism SLC33A1 B3GALT4 ST3GAL5 ST8SIA5 B4GALNT1 ST6GALNAC6 A3GALT2 FUT1 ST3GAL1 B3GALT1 ST8SIA1 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20220510%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis PARP1 RIPK3 FTL hCG_16983 RIPK1 FADD MAPK8 TNF-alpha TRADD TICAM1 TNFRSF1A 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome ASCL1 MYOG GBX2 NEU4 UGT1A5 TNF-alpha PDX1 MEF2C MTERF4 D2HGDH RAC1 TRAF3IP1 TRAF3 NEDD8 PDCD1 BOK HAMP MAP1LC3A MAP1LC3C DKFZp762B153 ACKR3 DGKD HJURP ERFE RRAGA UGT1A1 KLHL30 RRAGB UGT1A8 GABARAPL1 THAP4 RRAGD NFKBIA AGAP1 MYOD1 GABARAP MLPH OR6B3 TRPM8 RAB27A OR6B2 UBE2F CALM3 CALM2 COPS9 SNED1 DISC1 RTP5 NDUFA10 PRH MAP4 ING5 SEPT6 CAPN10 KIF1A ILKAP AQP12B AQP12A ITPK1 DUSP28 ANO7 OTOS ARL4C USP40 ARF5 CENPA ASB18 CYTH2 UGT1A4 SH3BP4 SPP2 HES1 UGT1A3 ANKMY1 SEPTIN4 IRF8 UGT1A9 FARP2 RAB17 UGT1A7 ASB1 GYS1 CALCRL PPP1R7 ARF1 ABCA1 GPC1 JUN UGT1A10 DTYMK RPS6 PRL CXCL11 CXCR4 EEF1A1 TWIST2 HEL-S-28 PER2 AGXT RAMP1 GAL3ST2 ITGB3 IL1B COPS8 CALCA CYTH3 HES6 CXCL12 IL13RA1 HDAC4 EGFR GABARAPL2 PDGFA IL-7 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP205%HOMO SAPIENS IL-7 signaling pathway PIK3R2 JAK1 STAT5B STAT3 PIK3R1 PTK2B MAP2K1 GSK3B CDKN1B STAT1 JAK3 IL2RG MAPK1 IL7 FYN CCND1 BCL2L1 MAP2K2 BAD IL2RA MAPK3 IL7R MYC GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20220510%WP4159%HOMO SAPIENS GABA receptor signaling AP2M1 SLC6A1 GABRG2 SLC6A11 ALDH9A1 GABRB2 GABRG3 AP2A1 GAD2 GABRG1 GPHN GABRB1 GABRE GABRA2 GABRA5 GABRQ GABRP GABRA6 GABRA4 AP2A2 AP2S1 GABRA3 GAD1 GABBR2 GABRB3 GABBR1 SLC32A1 ABAT PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20220510%WP5088%HOMO SAPIENS Prostaglandin signaling IL8 IL12A PTGES NFKB1 AREG TNF-alpha AHR PYCARD NLRP3 IL17F IFNA1 CXCL9 CSF1 CXCL1 CCR2 MMP9 IL17A IL1B IL1A IL6 IRF7 TGFB1 CCL2 PTGER4 CCL3 VEGFA KLRD1 IF2F CXCL10 PTGER2 RANKL/RANK SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2018%HOMO SAPIENS RANKL/RANK signaling pathway PIK3R2 PIK3R1 MAP2K1 CHUK FOS VCAM1 MAPK14 MITF-C NFKB1 IKBKB CALCR MAPK9 MAPK1 IKBKG TRAF2 RAC1 TNFSF11 SQSTM1 MAP3K7 STAT1 JUN TRAF6 GAB2 SYK CDC42 TRAF3 TRAF5 LYN PAPSS2 NFKB2 MAPK3 MAP2K6 TNFRSF11B CBL MAP3K7IP1 DKFZp666O0110 TRAF1 FHL2 RELA NFATC1 DKFZp434N101 MTOR NFKBIA SPI1 TNFRSF11A CTSK ACP5 SRC RELB MAPK8 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20220510%WP4963%HOMO SAPIENS p53 transcriptional gene network ADGRB1 TP53INP1 RPRM GPX1 ZMAT3 SIVA1 PERP ULBP1 XPC TNFSF6 TNF-alpha ERCC5 BBC3 ALDH4A1 raptor ISG15 FANCC BTG2 PRKAG1 SERPINE1 PRKAG2 PRKAG3 MLST8 NCF2 SESN2 PRKAB2 DKFZp686A24188 ADORA2B TP53AIP1 XRCC5 PIDD1 SESN1 CCNE1 IRF9 TSC2 PMAIP1 PCNA PML TP53I3 CPT1C CCNG1 PRKAB1 AURKA CX3CL1 DEPTOR AKT1S1 MGMT FAS ULBP2 TIGAR SLC7A11 PRKAA1 APAF1 DDB2 TRAF4 PRKAA2 GADD45A SFN POLK CDK2 MTOR DDIT4 ULK2 ULK1 PTEN CDKN1A THBS1 LIF CCL2 NOTCH1 MSH2 IRF5 TNFRSF10D GLS2 FLJ11259 SMR3B ACAD11 E2F7 SERPINB5 RRM2B BAX METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20220510%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders MAT1A MTR DKFZp727E011 ADK HEL-S-182mP CDO1 AHCY pcap CTH HEL-S-61p RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20220510%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation IL12B IL8 IL12A RETN CHUK MAPK14 NFKB1 IKBKB RELA PIK3CA TNF-alpha MAPK1 IKBKG PLCB2 PLCE1 DKFZp434N101 PIK3CD NFKBIA AKT3 PLCG2 PLCB1 IL6 PLCB3 PLCB4 PLCD3 PLCD4 MAPK3 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20220510%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20220510%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 NOD-LIKE RECEPTOR (NLR) SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP288%HOMO SAPIENS Nod-like receptor (NLR) signaling pathway CD40 CHUK MAP3K7 IKBKB RELA ERBIN MAPK8 IKBKG EPHB2 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20220510%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GNRH1 SST GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20220510%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids AGPAT4 PTDSS1 GPAT4 PNPLA2 CDS1 hCG_16873 PCYT2 PNPLA3 CRLS1 GPAM ETNK1 PEMT CHPT1 CDIPT DGKZ PLA2G1B PTDSS2 PISD DGAT2 DGAT1 T-CELL ANTIGEN RECEPTOR (TCR) PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20220510%WP3863%HOMO SAPIENS T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection MAP2K1 CHUK RRAS FOS CHP1 NFKB1 AHSA1 IKBKB MAPK9 PIK3CA TNF-alpha IKBKG ICOS MAP3K8 MAP3K7 PTPRC JUN PAK1 IL2 ITK PRKCQ LAT LCK CDK4 ZAP70 MAPK3 CD8A CBL PTPN6 PDCD1 DAG1 SOS1 GSK3B NFATC2 DKFZp434N101 NFKBIA GRB2 CALM3 CALM2 CSF2 IL10 FLJ00120 IL4 CD3D CTLA4 GRAP2 IL5 FYN LCP2 MAP2K2 BCL10 NCK1 RAF1 IF2F DKFZp686J04131 CD40LG CAMKK2 PATHWAY%WIKIPATHWAYS_20220510%WP4874%HOMO SAPIENS CAMKK2 pathway MAP1LC3A VCAM1 CAMKK2 FIS1 RELA WFS1 STIM1 MAPK1 NFATC2 MAF CHRM3 raptor EP300 MTOR CREB1 SMC1A RAC1 CALM3 CALM2 SQSTM1 HMOX1 SIRT1 KIAA0142 HDAC4 TSC1 CAMK4 CAMK1 RAF1 MAPK3 NFE2L2 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20220510%WP2858%HOMO SAPIENS Ectoderm differentiation TRPM2 TCF7L1 NR2F2 WNT1 TFAP2A DKFZp566E044 FZD5 FZD4 POU2F2 FGFR2 BMP4 PAX6 FZD8 LHX1 CDH8 SKIL GATA6 DKFZp686D0714 PP2150 ZNF219 TBL1X ARHGDIG TNFRSF11B FOXA2 SMURF1 ZBTB16 SPRY2 RGMA NR1C2 NFATC1 SMAD4 BMPR1A MKS1 GLI3 DMD PDE7A SOX2 AHI-1 NF2 CCL2 SHH KRT6A TNLG7C PTPN13 ROR2 CTBP1 MYC PIK4CA NLK TCF3 CTNNB1 ELOVL4 FLJ00166 CTNND2 ELOVL2 KCNK10 LY6E ASTN1 OGT ARX STC1 PLXNA2 ARHGAP15 ZBTB2 HESX1 SNCA ST8SIA4 RHPN1 GAS2L1 ZBTB7B GREB1 PRKAG2 PAN2 PTPRB NLGN1 PPFIBP2 MAFB NUMA1 ZNF42 WDR44 SIX6 UBTF RAB8B BCAS3 SORCS1 FOXL1 BAZ1A SERPINB6 ARHGAP10 ARHGEF9 RUTBC3 STX16 RRBP1 CLVS1 ZFHX4 H2BC9 C1GALT1 VAX2 RIT1 MYORG SCHIP1 BCOR SDCBP TOX3 FHL2 JUP LDB2 CTNNA2 HMGB2 CLDN11 HDAC10 TFAP2C CDH6 BOC PAX3 CDON CELSR2 PIM1 FYN SOCS2 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) %WIKIPATHWAYS_20220510%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 (PRC2) SUZ12 EZH1 AEBP2 EZH2 SETX EED MORC3 ELL BCLAF1 STK38 RBBP7 TRIM35 THRAP3 JARID2 RBBP4 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20220510%WP5166%HOMO SAPIENS Glyoxylate metabolism AGXT ALDH4A1 HEL-S-133P SLC26A1 DAO PXMP2 HAO1 HOGA1 GOT2 PRODH2 RETINOL METABOLISM%WIKIPATHWAYS_20220510%WP5188%HOMO SAPIENS Retinol metabolism DHRS9 PNPLA4 DHRS4L2 ADH1A AOX1 HEL-S-53e CYP3A7 SDR16C5 RDH12 AWAT2 CYP2W1 LRAT BCO1 RPE65 CYP2A6 CYP1A1 DHRS4 NON-SMALL CELL LUNG CANCER%WIKIPATHWAYS_20220510%WP4255%HOMO SAPIENS Non-small cell lung cancer PIK3R2 PIK3R1 STAT5B STAT3 MAP2K1 BRAF RASSF1 hCG_16983 PIK3CA MAPK1 CCND1 CASP3 PRKCB PIK3CD TGFA ALK AKT3 STK4 HRAS JAK3 RXRB CDK6 GADD45B CDK4 MAPK3 ARAF EGF RB1 SOS1 EML4 SOS2 PRKCA RARB FOXO3A CASP9 DDB2 GADD45A FHIT BAK1 RXRG GADD45G NRAS POLK BAD DKFZp434N101 CYCS KRAS CDKN1A GRB2 E2F2 E2F3 PLCG2 CRABP2 CRABP1 CDKN2A MAP2K2 EGFR RAF1 RXRA ERBB2 PIK3R3 BAX TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20220510%WP619%HOMO SAPIENS Type II interferon signaling MHC2TA HIST1H4J GBP1 PTPN11 IRF2 IFI6 IRF4 NOS2 EIF2AK2 ISG15 TAP1 JAK1 OAS1 CXCL9 IRF1 IF1DA1 SPI1 SOCS1 STAT1 IL1B STAT2 IFIT2 CYBB IF1AB4 IRF9 HLA-B IRF8 IFNGR1 IFNGR2 IF2F SOCS3 CXCL10 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20220510%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R2 PPP2CA PIK3R1 HLA-DRB1 CD80 PTPN11 PIK3CD PIK3CA PTPN6 CTLA4 PIK3R3 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20220510%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway FDPS IDI1 MVK HMGCS1 CYP51A1 MSMO1 HMGCR DKFZp686B0215 PMVK MVD DHCR7 SC5DL FDFT1 APOPTOSIS%WIKIPATHWAYS_20220510%WP254%HOMO SAPIENS Apoptosis PIK3R1 CHUK HELLS NFKB1 TNFRSF21 hCG_16983 IKBKB TNFSF6 BNIP3L TP73 hCG_20684 BCL2 TNF-alpha IKBKG IRF4 BBC3 CASP6 CASP3 TRAF2 IGF2 TNFRSF1A IRF1 IGF1R MAP2K4 JUN DKFZp686A24188 TP63 IRF7 IRF6 IRF3 TRAF3 PMAIP1 RIPK1 FADD MAPK10 FAS BCL2L2 CASP10 BOK NFKBIB IRF2 SCAF11 TRAF1 TNFRSF1B APAF1 MDM2 RELA IGF1 CASP9 BAK1 NFKBIE BAD BCL2L11 NFKBIA TRADD DIABLO CYCS HRK MAP3K1 CASP4 TNFSF10 DFFB BIRC2 DFFA BIRC3 TNFRSF25 MCL1 CRADD BCL2L1 PRF1 CDKN2A LTA IRF5 BIRC5 MYC BAX ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20220510%WP2197%HOMO SAPIENS Endothelin pathways MAP2K1 CALCRL PRKCA ATP2A2 EDN1 RIIAD1 HEL-S-14 MAPK1 HEL-S-7a NPY GNAI1 GNAS ADRA1A GNA15 GNB5 ECE1 CALM3 PTGIR CALM2 COX2 RAMP1 NPY1R EDNRA EDNRB PLCB1 MYLK CALCA ADRB1 GNG13 MYL1 RAF1 CAD CANONICAL AND NON-CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20220510%WP3845%HOMO SAPIENS Canonical and non-canonical Notch signaling PSEN2 CHUK DLL3 DLL4 RRAS MAML2 DKFZp586H0919 DKFZp762E1511 ADAM10 DLK2 MFAP2 MAML1 DNER JAG2 DKFZp434N181 HES1 NOTCH3 NOTCH1 MFAP1 HEY1 PSEN1 RBPJ CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20220510%WP536%HOMO SAPIENS Calcium regulation in cardiac cells GNG12 RGS2 GNAI3 GNA11 GNG2 PRKCB GNAO1 ADRA1D ARRB2 CXNG GJA4 ADRA1B ADRA1A PRKCZ SLC8A1 CXNK2 PRKCQ GJB2 GJB6 ADCY3 ADCY6 ATP2A2 CAMK2D PRKCH CAMK2A RGS16 PRKCE RYR1 RYR2 GNAQ GNAI1 CACNB1 GNAZ RYR3 CAMK2G CACNB3 FKBP1A ADCY9 CACNA1D GNAS KCNJ3 CACNA1S GJA8 CALM3 CALM2 KCNJ5 GJA5 PLCB3 PLN CACNA1C ATP2B3 ATP2B2 GNGT1 GNB1 GJA3 ATP2B1 HEL-S-99n PRKAR1B ADRB3 GNG11 HEL2 GNG13 ITPR2 PRKCA RGS4 RGS5 RGS6 RGS7 ATP1B3 PRKAR1A ATP1B2 RGS10 ATP1B1 STIM2 ADCY1 FXYD2 ADCY8 GRK5 ANXA6 GRK4 SFN CASQ2 CASQ1 ATP1A4 PKIB CXNS PKIA KCNB1 YWHAQ CXNQ CHRM2 HEL-S-1 CXNO CHRM3 PKIG YWHAG CXNM CHRM1 YWHAZ CXNC RGS18 CXNB GNB2 RGS17 CXNA CHRM4 GNB4 GNB3 CHRM5 GNB5 RGS14 RGS20 RGS11 CACNA1B CACNA1A GNG3 GNG5 RGS1 GNG4 ADRB1 GNG7 ADRB2 GNG8 CAMK4 CAMK1 PRKD1 METHYLATION PATHWAYS%WIKIPATHWAYS_20220510%WP704%HOMO SAPIENS Methylation pathways NNMT MAT1A PNMT INMT TPMT PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP3942%HOMO SAPIENS PPAR signaling pathway FABP5 FABP6 SLC27A4 NR1H3 FADS2 FABP1 SLC27A1 ACADL CD36 SLC27A5 PCK1 RXRB PLTP ACSL1 SLC27A2 FACL4 ACSL5 PCK2 ACSL3 CPT1C CYP27A1 AQP7 PPARG PLIN1 DBI NR1C1 PDPK1 NR1C2 HEL-S-28 UCP1 RXRG CPT2 ACADM ME1 LPL CYP4A11 OLR1 APOA2 APOA1 APOA5 ACOX1 EHHADH ACOX2 ACOX3 ANGPTL4 CYP7A1 RXRA APOC3 SCD FABP2 FABP4 DNA IR-DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20220510%WP4016%HOMO SAPIENS DNA IR-damage and cellular response via ATR MDC1 RAD51 FEN1 XPA SHFM1 TP53BP1 MCPH1 IKBKG hCG_37731 TREX1 CHEK1 HUS1 BRIP1 TOPBP1 HERC2 ATR FANCA RAD9A TRIM28 PALB2 PARP1 SMARCC2 XRCC5 CDC2 FANCD2 PCNA PML SP1 BRCA1 CHEK2 BARD1 PLK1 MDM2 FOXM1 PRKDC BCL6 RAD52 RAD50 CDK2 RPA1 MRE11A H2AX ATM NBN RECQL BRCA2 WRN DCLRE1A CEP164 RAP80 RMI1 SMC1A EEF1E1 ABRAXAS1 BRCC3 UBE2D3 MCM2 CLSPN PP1045 POLN SMARCAL1 CDC45 TDP1 RFWD3 USP1 CLK2 RAD17 MSH2 PPM1D RBBP8 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20220510%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT2 NOS2 PRMT1 HEL-S-277 PRMT7 CARM1 PRMT3 PRMT6 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20220510%WP3941%HOMO SAPIENS Oxidative damage response CDKN1C CDKN1B CR2 TRAF1 NFKB1 TNFRSF1B APAF1 CASP9 GADD45A BAK1 BCL2 TNF-alpha NFKBIE CASP3 BAD MAPK13 C1S TRAF2 C1R CYCS CDKN1A C5AR1 MAP3K1 C4B_2 C2 TNK2 MAP2K4 BAG4 C3AR1 TRAF6 CDC42 TRAF3 ADIB ADIC ADIA PCNA MAPK10 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV-1 LTR%WIKIPATHWAYS_20220510%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV-1 LTR HDAC9 HDAC7 NFKB1 RELA NFATC1 NFATC2 EP300 NFKBIA PPP3CA PPP3R2 SUPT4H1 NELFB NELFCD NELFA HEXIM1 PPP3R1 PPP3CC SUPT5H HDAC4 HDAC5 NFATC4 HDAC2 CREBBP HDAC3 NFATC3 SP1 HDAC1 CDK9 HDAC8 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20220510%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation STAT3 GSK3B PRKCA APC RHO DVL1 PIK3CA MAP1B TRIO GNAQ WNT3A F2RL2 PTPRA PTEN FREP1 RAC1 MAPKAPK2 CLASP1 PARD6A ROCK1 TIAM1 SRC CFL2 EPHB2 MARK2 MAPRE1 CDC42 PHLDB2 SPRED1 MARK1 PAK1 CDC2 CAMK4 TAOK1 AURKB LIMK1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20220510%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MECR OXSM HSD17B12 MCAT ACACA INTERLEUKIN-11 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2332%HOMO SAPIENS Interleukin-11 signaling pathway PIK3R2 PIK3R1 STAT3 MAP2K1 CHUK PTPN11 BGLAP PDPK1 ATF1 IKBKB RELA ITGA2 RUNX2 hCG_2011440 BCL2 MAPK1 IL6ST IL11 CREB1 RPS6KB1 JAK1 GRB2 RPS6KA1 PIAS1 HRAS STAT1 SRC TYK2 IBSP FYN TGFB1 RPS6 YES1 MAP2K2 PTPA FES RAF1 MAPK3 BIRC5 SOCS3 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20220510%WP4917%HOMO SAPIENS Proximal tubule transport ATP1A1 ATP6V1C1 SLC22A11 ATP6V1E1 ATP6V1F DKFZp586E1422 SLC2A2 ATP6V0B ATP6V0E1 AQP1 SLC6A19 SLC36A2 SLC6A18 HEL-76 SLC7A9 ATP6V0D2 ATP6V0C SLC3A2 ATP6V1B1 ATP1B1 FXYD2 SLC5A8 SLC16A10 SLC9A3 ABCB1 ABCC2 SLC1A1 SLC5A1 SLC6A20 SLC5A2 SLC22A7 SLC5A5 ABCG2 ATP6V1G1 SLC34A3 SLC34A1 ATP6V1A SLC47A2 SLC22A6 SLC47A1 SLC22A2 SLC3A1 SLC4A4 CLTRN SLC7A7 CA4 ATP6V0A4 ATP6V1D TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20220510%WP465%HOMO SAPIENS Tryptophan metabolism TPH1 CYP1B1 AANAT TDO2 CYP2A13 CYP2F1 KYNU HAAO DDC AFMID AOC1 ASMT HEL-S-53e ALDH3A2 ALDH2 ALDH1A2 ALDH9A1 ECHS1 GCDH HSD17B10 CYP2J2 ACAT1 WARS PRMT1 AADAT DHCR24 IDO1 AOX1 CYP3A4 CYP4F12 CYP7B1 INMT DKFZp686I24235 OGDH CYP2E1 CYP1A2 CYP1A1 AMINO ACID METABOLISM IN TRIPLE-NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20220510%WP5213%HOMO SAPIENS Amino acid metabolism in triple-negative breast cancer cells PSPH DKFZp686O15119 SLC7A11 PSAT1 PHGDH SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20220510%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis MESP2 LFNG EPHA4 RIPPLY2 DLL3 TBX6 NOTCH1 HES7 PHOTODYNAMIC THERAPY-INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20220510%WP3613%HOMO SAPIENS Photodynamic therapy-induced unfolded protein response TRIB3 PPP1R15A HEL-S-89n EIF2A XBP1 SULT1E1 NARS1 EDEM1 DNAJC3 DNAJB11 DDIT3 ERP27 BBC3 BCL2L11 DNAJB9 WARS HEL-S-99n ASNS HEL-S-125m ERN1 ATF4 UBE2E1 ATF3 DKFZp781H1925 NFE2L2 PURINERGIC SIGNALING%WIKIPATHWAYS_20220510%WP4900%HOMO SAPIENS Purinergic signaling P2RY13 P2RY10 P2RY11 P2RY14 GNAI1 GNAZ P2RY8 GNAI3 PANX1 P2RX6 GNAT2 GNAT3 GNAT1 GNAO1 P2RX7 P2RX5 P2RX4 GNAS P2RX3 P2RX2 P2RX1 ADORA2A ADORA2B P2RY6 P2RY4 LPAR4 P2RY2 P2RY1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN-CONTAINING MONOOXYGENASES (FMOS)%WIKIPATHWAYS_20220510%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs) FMO5 DKFZp667E137 FMO4 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20220510%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies PPARG GSK3B JUNB DKFZp586H0919 DICER1 APC WNT10B AXIN1 GDF8 CTNNB1 TCF7L1 CSNK1A1L SPP1 RUNX2 HES5 TCF7L2 MAOA EMD AGO2 LEMD3 BMP2 ZMPSTE24 MYOD1 FNTA LMNA CDKN1A WNT7B PS1TP5BP1 KAT2B CTSK HMGA2 SMAD2 TGFB1 HES1 TARBP2 NOTCH1 CSNK1A1 CREBBP CDK4 HDAC1 TNFRSF11B CEBPA RB1 CEBPB CEBPD PI3K/AKT/MTOR - VITAMIN D3 SIGNALING%WIKIPATHWAYS_20220510%WP4141%HOMO SAPIENS PI3K/AKT/mTOR - vitamin D3 signaling IL12A HK3 GSK3B CD80 HEL-S-133P SLC2A3 IL10 RELA PRKAA2 PIK3CA PFKFB4 HLA-DRA PDHA1 TSC2 TSC1 MTOR RXRA CYP24A1 NR1i1 MYC ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20220510%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA1 ACHE ChAT PEMT CHKA PDHA2 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP524%HOMO SAPIENS G13 signaling pathway PIK3R2 HEL-S-15 ARHA CIT ARHGDIB PKN1 PIK3CA HEL-S-80p PIK3CD WASL RPS6KB1 RTKN SH3RF1 RHPN2 RAC1 MYBPH CALM3 CALM2 TNK2 ARHGEF1 ROCK1 ROCK2 WAS CFL2 PIP4K2A CDC42 GNA13 hCG_1991735 MYL1 CYFIP1 PFN1 ARHGDIG MAPK10 LIMK1 HIF1A AND PPARG REGULATION OF GLYCOLYSIS%WIKIPATHWAYS_20220510%WP2456%HOMO SAPIENS HIF1A and PPARG regulation of glycolysis PPARG HMFN0839 GPD1 HEL-S-133P HEL-S-162eP HEL-S-49 HIF1A AUTOPHAGY%WIKIPATHWAYS_20220510%WP4923%HOMO SAPIENS Autophagy ATG12 FLJ10035 RB1CC1 PRKAA1 DKFZp762B153 PRKAA2 AMBRA1 C12orf44 WIPI2 ATG14 raptor MTOR PRKAG1 PRKAG2 PRKAG3 ULK1 ATG9A MLST8 ATG5 PRKAB2 UVRAG PIK3R4 PRKAB1 DEPTOR ATG3 AKT1S1 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20220510%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling PPARG GSK3B DKFZp586H0919 DICER1 APC SLC2A4 WNT10B AXIN1 CTNNB1 TCF7L1 CSNK1A1L SPP1 RUNX2 HES5 TCF7L2 CCND1 EMD AGO2 ZMPSTE24 FNTA LMNA TOR1AIP1 HMGA2 CDK6 HES1 TARBP2 CSNK1A1 CEBPA CEBPB CEBPD BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20220510%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders HEL74 UMPS RRM1 RRM2 HEL-S-29 DPYS TYMS NT5C3 DPYD TYMP DHODH RRM2B DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20220510%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport AKR1D1 BAAT SLC27A5 ACOX2 AKR1C4 SLCO1B1 AMACR HSD3B7 SLC27A2 ABCB11 CYP7B1 CYP7A1 ABCC2 ATP8B1 ABCB4 CYP27A1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20220510%WP2253%HOMO SAPIENS Pilocytic astrocytoma GRB2 SOS1 PTPN11 BRAF NF1 RAF1 NON-HOMOLOGOUS END JOINING%WIKIPATHWAYS_20220510%WP438%HOMO SAPIENS Non-homologous end joining XRCC5 POLM NHEJ1 WRN PRKDC ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20220510%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFK MAP2K1 MAP2K2 PRKCQ SP1 hCG_1991559 MAFF CYP2E1 MAPK8 NFE2L2 REGULATION OF WNT / B-CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20220510%WP3664%HOMO SAPIENS Regulation of Wnt / B-catenin signaling by small molecule compounds MBOAT1 GSK3B DKFZp586H0919 APC AXIN1 CTNNB1 DVL2 WNT1 DKK3 FZD1 CSNK1A1 FZD7 SFRP4 FZD8 TNKS TCF4 LINOLEIC ACID METABOLISM AFFECTED BY SARS-COV-2%WIKIPATHWAYS_20220510%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS-CoV-2 ACOT2 FADS2 FADS1 ELOVL5 ELOVL2 ACE2 GLIOBLASTOMA SIGNALING PATHWAYS%WIKIPATHWAYS_20220510%WP2261%HOMO SAPIENS Glioblastoma signaling pathways PIK3R2 PIK3R1 MAP2K1 BRAF ERRFI1 PIK3CA MAPK1 CDKN2B CDKN2C CCND1 PRKCI PRKCB FGFR2 CCND2 EP300 PIK3CD PIK3C2G PIK3C2A PIK3C2B FOXO4 PRKCZ AKT3 IGF1R MAP2K5 HRAS MAP2K4 MAP2K3 FOXO1 CDK6 ERBB3 CCNE1 MDM4 TSC2 PRKCQ TSC1 CDK4 MAPK3 ARAF MAP2K6 CBL RB1 BRCA1 CDKN1B PRKCA FOXO3A PDPK1 MSH6 SPRY2 PRKCH MDM2 NRAS CDK2 NF1 DKFZp434N101 ATM BRCA2 PTEN KRAS CDKN1A GRB2 FGFR1 IRS1 PLCG2 SRC PDGFRA CDKN2A MAP2K2 EGFR RAF1 ERBB2 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20220510%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGER3 PPARG TBXAS1 PTGES CYP11A1 MITF-C EDN1 AKR1C1 AKR1C2 ANXA6 AKR1B1 ANXA2 ANXA1 PPARGC1B PTGIR PTGFRN HPGD S100A10 ANXA3 EDNRA ANXA4 SCGB1A1 EDNRB PPARGC1A HSD11B1 HSD11B2 PTGDR PTGS2 SOX9 PTGDS S100A6 PRL PTGER4 PTGFR HEL-S-7 PTGER1 PTGS1 TBXA2R PTGIS PTGER2 LEPTIN SIGNALING PATHWAY%WIKIPATHWAYS_20220510%WP2034%HOMO SAPIENS Leptin signaling pathway PIK3R2 PDE3B PIK3R1 STAT5B STAT3 MAP2K1 CHUK PTPN11 MAPK14 NFKB1 IKBKB GSK3A MAPK1 IKBKG CCND1 RAC1 JAK1 RPS6KA1 HRAS STAT1 KPNA4 KHDRBS1 ROCK1 SOCS7 ROCK2 FOXO1 ACACB CDC42 RPS6 IL1RN CISH SP1 MAPK3 PTPN1 DKFZp666O0110 LEP SOS1 GSK3B ARHA SH2B1 PRKAA1 RELA PRKAA2 SHC1 ACACA REL NCOA1 BAD DKFZp434N101 CREB1 MTOR RPS6KB1 PTEN GRB2 IRS1 LEPR IL1B PLCG2 SRC CFL2 FYN EIF4E BCL2L1 MAP2K2 SOCS2 RAF1 SOCS3 MAPK8 ERBB2 EIF4EBP1 BAX BDNF-TRKB SIGNALING%WIKIPATHWAYS_20220510%WP3676%HOMO SAPIENS BDNF-TrkB signaling EEF2K MAP2K1 SOS1 BRAF ARC SHC1 ADCY1 MAPK1 NRAS TRPC3 HOMER1 BDNF DKFZp434N101 MTOR CREB1 GRIN1 DLG4 RPS6KB1 RHEB KRAS GRB2 RPS6KA1 HRAS TRPC6 MKNK1 GAB2 NTRK2 TSC2 TSC1 EIF4EBP1 SERINE METABOLISM%WIKIPATHWAYS_20220510%WP4688%HOMO SAPIENS Serine metabolism PSPH PSAT1 PHGDH SHMT1 DHFR HEL-S-51e TYMS DKFZp762A2415 STEROL REGULATORY ELEMENT-BINDING PROTEINS (SREBP) SIGNALING%WIKIPATHWAYS_20220510%WP1982%HOMO SAPIENS Sterol regulatory element-binding proteins (SREBP) signaling ACLY INS CDK8 MBTPS2 GPAM PIK3CA NR1H2 LPIN1 GSK3A INSIG1 PRKAG1 PRKAG2 FGF8C SCARB1 PRKAG3 NFYA MED15 SIRT1 SREBF2 ACSS1 LDLR SEC23A PRKAB2 SAR1A SAR1B RNF139 SEC23B SEC31B SEC31L1 hCG_1811773 SEC24C SP1 HEL-S-32 FASN PRKAB1 PPARG DBI PRKAA1 YY1 PRKAA2 ACACA MBTPS1 LPL CREB1 MTOR PPARGC1B FDPS IDI1 HMGCS1 CYP51A1 HMGCR DKFZp686B0215 MVD CAMP FDFT1 RBP4 SCD AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20220510%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction CALM3 CALM2 ARHA IL13 RYR1 ROCK1 PLCB1 PPP1R14A ROCK2 MYLK GDI1 GNAQ HEL-S-80p ADRB2 MYL1 2Q21.1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20220510%WP5223%HOMO SAPIENS 2q21.1 copy number variation syndrome RAC1 STAT3 ARHA APC TUBA2 DKFZp434G2016 AMER3 STMN2 LOC130074 MZT2A CCDC74A GPR148 POTEE CCDC42 CDC27