S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1-1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A13;CYP2A6;CYP2A7-1 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 EHHADH-1 ELOVL2 HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation ACAT2 ACAT1 GCDH ECHS1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5D ITPKA INPP5J INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS;CBSL CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS RRM2-1 RRM1 DUT DTYMK NME4-1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 DDC TPH1 AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis SLC27A2 ACSBG2 FADS2 ACSM3 ACSL1 ACSM5 ACSBG1 ACSM4 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 ACAT2 MVK ACAT1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 FDPS L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 ADH1C;ADH1B;ADH1A LRTOMT ALDH3A2 ALDH2 MAOB MAOA COMT PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair GAPDH-1 NAXE NAXD URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C IPMK INPPL1 SACM1L PTEN ITPK1 OCRL PLCB3 PLCB4 SYNJ2 PIK3CA INPP5B ITPKB PIK3C3 ITPKC PLCB1 MINPP1 PLCB2 PI4K2A INPP5A IPPK MTMR3 SYNJ1 PIK3R4 PIK3R3 PIK3R2 PIK3R1 INPP5D ITPKA PIK3R6 PIK3R5 INPP5J PLCG2 INPP5K PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH;LOC102724788 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT GPT2 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing SLC27A4 CERS3 TGM1 ALOX12B CYP4F22 ALOXE3 PNPLA1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD DHODH UMPS GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation GDA NT5C2 PNP-1 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA1 IMPA2 ISYNA1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) UQCRC1 NDUFS2 NDUFS1 UQCRC2 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB10 NDUFB6 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A NDUFC2;NDUFC2-KCTD14 CYC1 NDUFV3 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 COX6C UQCRQ NDUFAB1 NDUFS5-1 COX7B NDUFA13 NDUFA11 NDUFA12 COX4I1 NDUFA10 COX6A1 COX7C UQCRFS1 COX8A SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 AK1 AK2 GMPS AK3 AK5 PFAS AK7 AK8 ATIC GUK1 PPAT AK4-1 ADSL PAICS IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 GART NME4-1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMRK1 NMNAT3 NMNAT2 NMNAT1 NMRK2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt ALDH5A1 GAD1 GAD2 ABAT GLUL GLUD1;GLUD2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) UBIAD1 COQ3 COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 GMPS RRM2-1 GUK1 IMPDH1 IMPDH2 RRM1 NME4-1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME2 NME3 GUK1 DGUOK NME5 DCK NME1 NME6 NME7 NME4-1 AK5 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DIO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP-1 ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GGT5 GSTM3 GSTK1 GSTO2 GSTP1 MGST3 NAT8-2 MGST1 MGST2 GSTT1 GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA4 ANPEP GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 GART ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2-2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 DTYMK CMPK2 NME4-1 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis GPX4 ALOX15 ALOX12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATPAF2-2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP6V1F ATP5ME ATP6V0A1 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP5PD ATP5PB ATP5F1C ATP5F1D ATP6V0E2;ATP6V0E1 ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation SHMT2 SHMT1 MTHFD1 MTHFD1L FPGS L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis PFAS PPAT GART PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis ACAT2 SQLE ACAT1 EBP KCNH7 SC5D DHCR24 DHCR7 LSS FDFT1 HMGCS1-1 FDPS IDI1 MVK GGPS1 IDI2 PMVK MVD HMGCR NSDHL HMGCS2 HSD17B7 LBR TM7SF2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCS2 HMGCL BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR AKR1A1 CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation DBT ACAT2 BCKDHB ACAT1 BCAT1 DLD ACADSB HSD17B10 BCAT2 BCKDHA ECHS1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 BLVRA HMOX2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 ST8SIA2 ST8SIA3 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PCYT1B PCYT1A PEDS1-UBE2V1;PEDS1 CHKA AGPAT1 GNPAT AGPS CHKB FAR1 PCYT2 FAR2 ETNK2 ETNK1 CEPT1 SELENOI L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) TDO2 KYNU AFMID KYAT3 ALDH8A1 IDO2 IDO1 AADAT DHTKD1 KYAT1 GOT2-1 HAAO KMO ACMSD ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A13;CYP2A6;CYP2A7-1 HSD17B1 CYP19A1 HSD17B3 HSD17B7 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3GALT1 ST3GAL3 FUT6;FUT5;FUT3 FUT2 B3GALT5 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III AKR1B15;AKR1B10 AKR1B1 CYP2E1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT1A MAT2B MAT2A PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS NME4-1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2;ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGDS PTGR1-1 CBR1-1 PTGES PTGS2-2 PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation TPTE;TPTE2 INPP4A INPP4B SACM1L INPPL1 INPP5E PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 INPP5F INPP5D MTMR14 INPP5J INPP5K PIP4P2 PIP4P1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 TECR HSD17B12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis GPX4 ALOX5 ALOX15 ALOX12 EPHX3 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGR1-1 PTGES GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S EPHX3 CYP2J2-1 CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX15B DPEP2 LTA4H PTGS2-2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IPPK PPIP5K1 IP6K2 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2-2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 BDH1 OXCT1-1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3B2;ALDH3B1 ALDH1B1 PGM2 DERA ALDH3A1 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX5 ALOX15 ALOX12 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR-1 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 MAOA CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX1 GPX4 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT3 NMNAT2 NAMPT NMNAT1 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM AGPAT1 LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 CDS2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt BPGM MINPP1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III HACL1 ALDH3A2 FA2H GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 G6PC3 PC GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PCK1 FBP1 FBP2 BPGM PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 ALDH2 AOC3 MAOB MAOA AOC2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE;RPEL1 TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 TECR ELOVL1 HSD17B12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) SLC27A2 ACSBG2 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 HSD17B12 ACSM5 ACSBG1 ACSM4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGT5 GGCT GCLC GSS GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 PGM2 PYGB MGAM HKDC1 PYGM PYGL PGM1 HK2 GCK HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation DBT BCKDHB BCAT1 DLD ABAT BCAT2 ACAD8 ALDH6A1 HIBADH BCKDHA ECHS1 HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2-2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1-1 GOT1L1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 PGM2 HKDC1 PGM1 HK2 GCK HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage CDA TK2 TK1 TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 RRM2-1 RRM1 DUT DTYMK NME4-1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA3;GSTA1 GSTA4 GSTA3;GSTA5;GSTA1;GSTA2 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation GDA NT5C2 PNP-1 XDH ADA NT5C3A NT5E IMPDH1 NT5C1A IMPDH2 NT5C1B;NT5C1B-RDH14 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT1A MAT2B CBS;CBSL CTH AHCY MAT2A L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT1A MAT2B ADI1 APIP MTAP MRI1 SRM KYAT1 MAT2A ENOPH1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5J INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 ZFYVE16 BMPR2 BMPR1B ACVR2A SKI SMAD4 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP2 GGT5 LTA4H GSTM4 ALOX5 DPEP1 LTC4S PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B1;HSD3B2 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1;GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II XDH RBP4 RBP5 RBP1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation ALDH3A2 MAOB MAOA COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX15 ALOX12 EPHX3 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1-1 GOT1L1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHB LDHA;LDHC LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III ALDH3B2;ALDH3B1 ALDH1B1 ALDH3A2 ALDH2 MAOB MAOA SAT2 SAT1 ALDH3A1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKMT1A;CKMT1B CKM CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation DBT BCKDHB BCAT1 DLD MCCC2 AUH BCAT2 IVD HMGCL MCCC1 HMGCLL1 BCKDHA GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASRGL1 GOT1-1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation ADH1C;ADH1B;ADH1A ALDH3A2 ALDH2 MAOA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK7 AK8 AK4-1 ADSL AK1 ADSS1 AK2 ADSS2 AK3 AK5 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU AFMID IDO2 IDO1 HAAO KMO UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLD1 PLA2G6 PLB1 PLA2G2A-1 PLD3 PLD2 PLCZ1 OC90 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLCE1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4E PLCB3 PNPLA8 PLCB4 PLA2G4A PLCB1 PLCB2 PLCG2 PLCG1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1-1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK1 PPCS COASY PPCDC PANK3 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation ALDOC TKFC ALDOB TPI1 SI ALDOA KHK PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage NME2 NME3 TK2 TK1 NME5 TYMS NME1 NME6 NME7 CMPK1 CMPK2 CDA DCK DTYMK NME4-1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis PCYT1B PCYT1A CHKA CHPT1 CHKB CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization TDO2 ADH1C;ADH1B;ADH1A KYNU NMNAT3 AFMID NMNAT2 ALDH2 MAOB ALDH8A1 MAOA IDO2 IDO1 DHTKD1 TPH2 DDC TPH1 AANAT ASMT CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GCDH ECHS1 POR ACAT2 CYP4X1 ACAT1 CYP2C9;CYP2C19 CYP2U1 ALDH3A2 CYP2S1 CYP1A2 CYP1B1 QPRT NADSYN1 AKR1A1 HAAO KMO NMNAT1 ACMSD FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) SLC27A2 ACSBG2 HSD17B10 ACOX2 SCP2 EHHADH-1 ACOX1 ACAA1-1 HSD17B4 ACSBG1 HADH ECHS1 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine ALDH3A2 DDC MAOB AKR1A1 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 LARS2 GARS1 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 PNP-1 ADA APRT HPRT1 AK1 AK2 GMPS AK3 AK5 AK7 ADK AK8 GUK1 AK4-1 ADSL IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 NME4-1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC3 DEGS1 KDSR CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 DCTD RRM2-1 RRM1 DTYMK NME4-1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME2 CTPS2 NME3 CTPS1 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine CHDH ALDH7A1 SHMT2 SHMT1 BHMT DMGDH TCA CYCLE%BIOCYC%PWY66-398 TCA cycle MDH1 DLD MDH2 FH IDH3G DLST CS SUCLA2 SDHC IDH3B OGDH SDHD SUCLG2 SDHA SUCLG1 SDHB ACO2 IDH3A N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 HADHA HADHB-1 ACSBG1 HADH ACAA2 ECHS1 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC3 DEGS1 KDSR CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C;ADH1B;ADH1A SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 FUT2 B3GALT5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) ACAT2 TDO2 ACAT1 KYNU AFMID ALDH8A1 IDO2 IDO1 DHTKD1 HAAO GCDH KMO ECHS1 ACMSD PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT-1 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I RBP4 RBP5 RBP1 SDR16C5 ALDH1A3 ALDH1A2 ALDH1A1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL4 ST3GAL3 B4GALT2 B4GALT3 ST8SIA2 FUT6;FUT5;FUT3 B4GALT1 FUT9 CHST1 FUT1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPB1 UPP1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) FADS2 ELOVL5 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis GCNT2 GCNT3 B3GNT2 B4GALT2 B4GALT3 B4GALT1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis GPI TPI1 HK3 PGAM1 HKDC1 PGAM2 ENO1 ENO2 ENO3 HK2 GCK HK1 GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PKLR PFKL PKM PFKM PFKP BPGM HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS;CBSL CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis GCNT3 B3GNT2 B4GALT4 LALBA ST3GAL3 ST6GALNAC6 ST6GAL1 B4GALT2 FUT6;FUT5;FUT3 B4GALT1 FUT2 B3GALT5 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5C2 PNP-1 XDH NT5E IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis TYR DCT TRPC1 TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) NDUFAB1 OXSM MCAT ACSF3 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 HK2 GCK HK1 TREH LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX4 CYP2C9;CYP2C19 EPHX2 EPHX3 EPHX1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RDH8 RLBP1 RPE65 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B1;HSD3B2 HSD17B3 SRD5A2 SRD5A1 CYP17A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME2 NME3 GUK1 NME5 IMPDH1 NME1 NME6 IMPDH2 NME7 GMPS NME4-1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis LIPC BCO1 PNLIP CES2 CES1 RDH8 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RDH11 RDH10 LRAT CES5A DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 GPX4 ALOX5 ALOX15 ALOX12 EPHX3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI HK3 GALE HKDC1 PGM3 GNPNAT1 GNPDA1 UAP1 GNPDA2 HK2 GCK HK1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1-1 CDO1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis SLC27A2 ACSBG2 ACOT2;ACOT1 ACOT4 ELOVL7 ELOVL6 ACSL1 HSD17B12 ACOT7 ACSBG1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 HOGA1 GOT2-1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F3;CYP4F2;CYP4F12;CYP4F11 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism SLC27A2 ACSBG2 PTGR1-1 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 ACSL1 ACSBG1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PGM2 PNP-1 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation CDA TYMP UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 PIP4P1 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I SHMT2 SHMT1 MTR-1 ST20-MTHFS;MTHFS ALDH1L1 MTHFD2 MTHFD2L MTHFR MTHFD1 ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT1A MAT2B AHCY MAT2A ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP-1 ADA HPRT1 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX5 GPX8 CAT GPX1 SOD2 SOD3 GPX7 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C2 PNP-1 XDH ADA NT5C3A NT5E NT5C1A NT5C1B;NT5C1B-RDH14 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AKR1B15;AKR1B10 CYP2E1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis SHMT1 TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 ITPK1 OCRL SYNJ2 INPP5B ITPKB ITPKC INPP5A IPPK SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX15B GPX4 ALOX5 ALOX15 ALOX12 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation LIPC PNPLA2 PNLIP LIPF LIPE DAGLA LIPG PNPLA3 PNPLA4 LPL CEL DAGLB CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 TIGAR PFKFB4 PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) SHMT2 TYMS DHFR2;DHFR ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT3 NMNAT2 QPRT NADSYN1 NMNAT1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1-1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) FADS2 ELOVL5 ELOVL7 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) GCNT2 GCNT3 ST6GAL2 ST3GAL4 B3GNT2 ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CYP2E1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ADH1C;ADH1B;ADH1A ACSS2 ALDH3A2 ALDH2 ACSS1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation DBT BCKDHB MCEE DLD PCCA PCCB MMUT BCKDHA LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO2 FMO3 FMO4 FMO5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALM-2 GALK1 PGM2 GALE PGM1 GALT UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GPI HK3 GFPT2 GFPT1 HKDC1 PGM3 GNPNAT1 UAP1 HK2 GCK HK1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT GPT2 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) ALDH7A1 AASS AADAT DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation HACL1 SLC27A2 ALDH3A2 ACSM1 PHYH-4 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 FDPS THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1;TYW1B TYW3 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I GDE1 PLAAT2 PLAAT5 ENPP2 PLA2G1B NAPEPLD PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ACAT2 ACAT1 ACADSB ACSM1 ECHS1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis TDO2 KYNU NMNAT3 AFMID NMNAT2 IDO2 IDO1 QPRT NADSYN1 HAAO NMNAT1 KMO LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation SLC27A2 ACSL3 ACSBG2 ACSL1 ACSBG1 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DDHD1 DAGLA PLCB1 DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6AMT1 PNP-1 TRMT112 SLC34A2 SLC20A2 SLC20A1 AQP9 SLC2A1 LOC100509620;LOC112267859;AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I PGM2 PGM1 UGP2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2-2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB MPI GPI PMM1 PMM2 GMPPA CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) SHMT2 SHMT1 BHMT DMGDH SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation DBT BCKDHB SDSL DLD SDS BCKDHA GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP-1 HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation DBT BCKDHB MCEE DLD BHMT PCCA BHMT2 PCCB MTR-1 MMUT CDO1 SUOX AHCY MAT2A MAT1A GOT1-1 MAT2B CBS;CBSL CTH BCKDHA TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II FMO1 ADO PPCS ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MOGAT3 PLPPR2 PLPPR3 MOGAT1 PLPPR4 DGAT2 DGAT1 PLPP4 MBOAT7 PLPP3 MBOAT1 PLPP2 MBOAT2 PLPP1 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 AGPAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 MINPP1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1;TYW1B TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I FMO1 CSAD CDO1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle GOT1-1 MDH1 MDH2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 GFRA1 PTPN11 PRKCA FRS2 PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE PRKCA DAB2IP RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 PTPN11 CALM3;CALM1 EIF3A IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB PTPN11 ARHGAP35 IGF1R FRS2 KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 SMC4 CENPA NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 XPO1 UBE2I SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN MC4R APH1A POMC NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 PTPN11 CALM3;CALM1 KIF5B CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 PTPN11 ELF2 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 LAMC2 ITGA6 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 WWP1 PPP2R5A NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 PTPN11 FRS2 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 APH1A MAPK8 CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FOS PTPN11 FRS2 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 SAG CNGA1 RHO PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B RIMS1 SNAP25 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 PTPN11 NFATC4 MAPK10 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB PRKCA CXCR2 RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 CYP2C18-1 SOD1 C4BPB SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 PRKCA ADCY1 ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 XPO1 UBE2I SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 WWP1 EIF2A PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 XPO1 NFATC1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB PTPN11 CALM3;CALM1 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 PRKCA MST1R GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 AURKAIP1 MDM2-2 CENPA GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 APH1A KREMEN2 CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL WWP1 SHH NQO1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A PTPN11 CALM3;CALM1 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 MAPK8 POMC SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD PRKCA MALT1 ERC1 TNFAIP3 RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 PGD TKT HK2 HK1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism ALDOC ALDOB HKDC1 ALDOA KHK HK2 HK1 GALE GALT P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 MAPK14 MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 EIF4E MEF2D MAP3K7 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR RAC3 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway MAPK3 NOS3 BRAF IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 AKT3 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK IL15 PDPK1 IL11RA IL13 IL18 FOS IL1A IL23A IL3RA SOS1 IL6ST SOS2 IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 MAPK6 ELK1 IL12RB1 IL12RB2 STAT5A STAT5B MKNK1 STAT1 MKNK2 IL10RB STAT2 IL10RA STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL9 IL2RB SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis EPRS1 UROD RSAD1 HMBS CPOX PPOX EARS2 COX10 ALAD QARS1 FECH NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CHRNA3 KCNK9 CHRNA5 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA PPP1R1B GNB1 KCNK3 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system PER2 PER1 CRY2 CRY1 TPTEP2-CSNK1E;CSNK1E CSNK1D CLOCK ARNTL CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis MVD PDSS1 HMGCR LSS FDFT1 HMGCS1-1 FDPS SQLE MVK GGPS1 IDI2 PMVK IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIA1 GRIA2 SNAP25 STX19 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 SHANK3 VAMP2 SHANK1 VAMP3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 CDKN1A MAPK13 MAPK11 PIK3CD PIK3CB PIK3C2A AKT2 PIK3CG PIK3C2B AKT3 AKT1 HRAS PDPK1 PIK3CA CCNE1 PIK3C3 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 TP63 SIAH1 PIK3R3 TPTE;TPTE2 PIK3R2 RBL1 PIK3R1 CDK2 CCNG1 CTNNB1 NRAS ATM KRAS TP53 TP73 ATR THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PLCG1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 HRH1 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN1 PRKAR1A GRINA ITPR1 PRKACA-1 GRIN3A PRKCB GRIK5 GNA11 GRIK1 PLCB4 GNAQ GRIN2A HOMER1 PRKX GRM1 GRIN2C PRKACB-1 GRIN2B GRM5 GRIN2D PRKAR1B OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAP2K6 MAP2K3 MAP2K4 JUN MEF2C MAX TXN MAPK14 MAPK9 MAPK12 MAPK8 MAPK13 DDIT3 PLA2G4A MAPK11 BCL2 ELK1 MYC EEF2K STAT1 MKNK1 MKNK2 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 KCNK9 PRKX PRKACB-1 ADCY2 GNAI1 PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A HTR1E GNB1 HTR1F KCNK3 HTR1D HTR1A HTR1B GNAO1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ OXTR PRKCZ PLCG2 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 HTR4 GNAL ADCY2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GABBR2 GABBR1 ADCY9 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 PRKACB-1 ADCY2 PRKAR1B GNAI1 PRKAR1A CACNA1G PRKACA-1 GNAI3 ADCY7 PRKAR2B PRKAR2A GNB1 GNAO1 ADCY4 CACNA1B CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2B UBE2D4 UBA6 UBE2C UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 UBE2G2 UBE2D3;UBE2D2 UBE2D3-1 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 ATG7 UBE2K ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway GSK3B APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 CTNNB1 NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 WNT8A PSEN2 WNT8B LRP4 LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 WNT2 APBB3 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A LRP1B AFDN ACTB-1 NECTIN1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 IL4I1 ALDH1B1 ALDH3B2;ALDH3B1 ALDH2 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 MDM2-2 MDM4 TP63 TP53 TP73 COP1 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK3 PANK1 PPCS DCAKD METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation MAPK3 PPP3CA PPP3CB BLNK VAV3 SYK IKBKB NFKBIL1 VAV1 VAV2 BTK CD79B CD79A CD19 LYN MAP3K2 MAP3K3 CALM3;CALM1 NFKBIA MAPK10 PTPRC PTPN6 GRB2 CD22 CHUK FOS SOS1 SOS2 ITPR1 ITPR2 ITPR3 MAPK14 MAPK12 MAPK13 MAPK11 ARAF PIK3CD PIK3CB PIK3CG RAC1 HRAS JUN PRKCB MAPK9 MAPK8 PRKCD PIK3CA RAF1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 EIF4EBP1 PPP2CB;PPP2CA TP63 AKT2 AKT3 TP53 AKT1 TP73 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis LPL PLA1A PLCB1 PLCB2 DAGLA PLCB3 LIPH MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB PMM1 GMDS GMPPA PMM2 MPI MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN2 RORC MTOR ARNT TXN2 VHL TXN AKT2 HIF1A AKT3 EGLN1 CREBBP AKT1 EGLN3 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C CREB3L1 POLR2C CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L TBP BRF2 TAF12 PRKAR1B BRF1 PRKAR1A MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TBPL2 TAF8 TAF7 TBPL1 TAF6 PRKAR2B TAF4 PRKAR2A TAF2 CREB5 CREBBP OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNAI1 GNG2 GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 POMC GNB2 GNB4 GNAO1 GNB3 GNB5 ADCY2 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1A2 EDN1 MAPK3 GUCY1A1 ADCY9 NOS3 EDN2 EDN3 GNAS-1 ADCY3 ADCY10 AKT2 AKT3 ITPR1 ITPR2 ITPR3 GNA14 GNA11 PLCB3 PLCB4 ARAF GNAQ PLCB1 PLCB2 PRKACB-1 AKT1 ADCY2 PRKAR1B PRKAR1A PRKCG PRKACA-1 PRKCI PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA ADCY7 PRKAR2B PRKAR2A PRKCQ RAF1 GNAL ADCY4 PRKCZ GUCY1B1 ADCY1 EDNRA ADCY8 MAP2K2;MAP2K1 EDNRB ADCY6 PRKG2 ADCY5 MAPK1 PRKG1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis GCH1 FPGS TYMS DHFR2;DHFR 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 HTR2B GNA11 HTR2A GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway CSK LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 COL3A1 LIMS2 BCAR1 MAP3K2 MAP3K3 MAPK10 MAP3K4 MAP2K4 MAPK13 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 HRAS MAP2K3 MAPK9 MAPK8 PIK3CA PIK3C3 RAF1 PXN PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK3 BRAF PTK2 COL16A1 COL12A1 ITGA2B ARPC5L CRKL MAP3K5 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 ELMO1 COL8A2 COL4A5 ELMO2 ACTG1 COL8A1 TLN1 VCL COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 SOS1 PARVA PARVB SOS2 ARPC5 ARHGAP26 COL1A2 LIMS4;LIMS1 ARPC2 COL5A1 ARPC3 ITGA10 MAPK6 COL5A3 ACTBL2 ITGA11 COL5A2 COL20A1 COL9A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ARPC1A ITGB2 ILK LAMC2 SHC1-1 LAMC1 ITGAE RND2 ITGAL RND3 RND1 ITGAX COL10A1 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 ITGA8 FLNA RAPGEF1 ITGA7 COL6A3 ITGA6 ACTB-1 ITGA5 CRK DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 LAMA1 SRC LAMA4 COL11A1 LAMA3 COL11A2 NTN4 ASAP1 CDC42 MICALL1 PTK2B FLNB FYN PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARHGAP42 OPHN1 GRAP2 PDGFRB PDGFRA PDGFRL VAV3 ERF ERG SHC3 VAV1 PDGFB VAV2 PDGFA ARHGAP15 ARHGAP12 SRGAP3 SRGAP1 FLI1 MAP3K2 FEV GRAP ARHGAP9 GSK3A MAPK10 ARHGAP5 ARHGAP6 GRB2 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA JAK1 NCK1 GAB1 GAB2 ETV3 RPS6KB1 ELF1 ELF2 RPS6KB2 ELF3 ELF4 ELF5 RASA1 RASA2 RPS6KC1 PIK3R5 SPDEF MYCBP-1 SRF ELP1 USF2 ELK1 RAB11B RPS6KA4 NIN PKN2 RPS6KA5 MKNK1 MKNK2 MAP3K4 ITPR1 ITPR2 ITPR3 MAPKAPK2 ARAF ARHGAP1 PIK3CD PIK3CB ETS1 PIK3CG ARHGAP8;PRR5-ARHGAP8 HRAS JUN MAPK8 PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 RPS6KA3 RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 JAK3 CHUK PDPK1 FOS SOS1 SOS2 ARHGAP26 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 SHC1-1 ARHGAP10 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A SLC5A7 MYH1 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 CHRNA3 MYH11 MYH10 CHRNA5 MYH7B MYO10 CHRNA4 MYO5A CHRNA6 MYO19 MYO1G;MYO1D MYO9A MYO16 MYO1E MYO1B SLC6A8 MYO1C MYO1A MYO15A MYO5B MYO5C MYO1F CHRNB2 CHRNB4 ACTB-1 CHRNB3 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT4 JAK2 STAT6 JAK1 STAT5A STAT5B STAT1 JAK3 STAT3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PLCG1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 VASP PIK3CA NTN1 NTN3 ABLIM1 NTNG1 NTNG2 UNC5B PIK3R5 DCC NFATC3 NFATC2 PIK3R3 UNC5C PIK3R2 UNC5D PIK3R1 NFATC4 NTN4 RHOU CDC42 PLCG2 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC18A1 SLC6A2 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 INMT COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MAT1A MTR-1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 TUBB3;TUBB6 PFN3 ROCK1 ROCK2 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 LIMK1 ACTG1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 ACTA2 ARPC2 ACTA1 ARPC3 ACTBL2 MYH1 MYH3 ARPC1B MYO3B ARPC1A MYO3A MYH8 MYH9 MYH6 MYH7 MYH13 MYH14 MYH11 MYH10 MYH7B RHOC RAC1 ACTB-1 RHOU CDC42 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade MAPK3 IRS1 IRS2 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 MAP2K3 IRS4 IGF1R INS;INS-IGF2 INSR FOS INSRR IGF2 RPS6KB1 IGF1 IGF2R RPS6KB2 SOS1 SOS2 RASA1 RAF1 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway JAK2 JAK1 STAT1 IFNG IFNGR1 IFNGR2 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UCK1 NME4-1 NME2 NME3 UPRT UPP1 ADAT2 UCKL1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GRIA1 GRIA2 SNAP25 ADCY10 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 GRIN2A SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 VAMP2 VAMP3 GRM4 GRM7 GRM6 GRM8 CACNB1 STX1A CACNA1E VTI1A SLC17A7 GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A GNAI1 PRKACA-1 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 CACNA1B CACNA1A APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway MAPK3 IKBKB MAP3K5 AKT2 AKT3 NFKBIA MAPK10 CHUK FOS IGF2R ATF1 TP53 MAP2K4 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 CASP10 CASP3 TNFSF10 GZMH;GZMB-1 MAP4K2 DAXX ENDOG APAF1 TRAF2 PIK3CD TNFRSF1B PIK3CB TNFRSF1A GZMH-1 MADD PIK3CG LTA LTB CASP9 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF6 ATF3 JDP2 AKT1 BIRC2 ATF4 BIRC3 PRKCG ATF6B MAP2K3 CREM PRKCH XIAP JUN PRKCB RELA RELB CYCS-1 MAPK9 PRKCE MAPK8 BCL2L11 PRKCD RIPK1 BAK1 BCL2 PRKCA FADD PIK3CA MAP2K7 MAP4K3 MAP4K4 MAP3K1 PRKCQ CRADD BIK EIF2AK2 DIABLO-1 EIF2S1 NFKB1 NFKB2 ATF7;ATF7-NPFF PRKRA REL BAX FAS MAP3K14 BCL2L1 MAPK1 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway EXOC2 RALB MAPK3 PLD1 PLD2 BRAF RALGDS RGL1 GSK3B RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 PAK1 PAK3 PAK2 GSK3A MAPK10 GRB2 PDPK1 SOS1 SOS2 SRF ELK1 STAT1 KRAS STAT3 MAP3K4 MAP2K6 MAP2K4 ATF2 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 ARAF PIK3CD PIK3CB ETS1 PIK3CG RHOC RAC3 RHOA AKT1 RHOB RAC1 HRAS MAP2K3 JUN MAPK9 MAPK8 PIK3CA MAP2K7 PIK3C3 MAP3K1 RAF1 CDC42 NRAS MAP2K2;MAP2K1 MAP3K7CL RALA-1 MAPK1 TIAM1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin MAPK3 ITPR1 ITPR2 ITPR3 ARRB1 GNG10 ARRB2 GRK3 GRK2 GNG4 EGR1 AGT GNG8 AGTR1 PLCB3 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PRKCA GNB1 RAF1 ELK1 MAP2K2;MAP2K1 MAPK1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TAF7 TBPL1 TAF6 TAF4 TAF2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway MDM2-2 MDM4 CDKN1A HDAC1 CCNB1 WRN SUMO1 SIN3A CHEK2 SUMO3 TRAF2 SUMO2 HMGB1-1 AKT2 SFN MTA2 EP300 GTSE1 CDKN2D AKT3 GADD45B CDKN2A GADD45A CDC25C AKT1 SIRT1 PML GADD45G KAT2B KAT6B CDK1 PDPK1 PIK3CA CCNE1 PTEN TP63 TPTE;TPTE2 CDK2 ATM TP53 CREBBP TP73 ATR THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway PLCG1 SNAP25 SNAP23 SNAP29 VAMP8 VAMP1 TRH TSHB VAMP2 TRHR CACNB2 VAMP3 CACNB3 CACNB4 STX3 CGA CACNB1 CACNA1E GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI PRKCH GNG2 PRKCB PRKCE PRKCD PRKCA PRKCQ GNB1 CACNA1B CACNA1A PRKCZ PLCG2 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 SOAT1 SOAT2 HSD17B1 HSD17B2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CTNNB1 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 ACTC1;ACTG2 WNT2B FZD10 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ACTB-1 UNTITLED%PANTHER PATHWAY%P06664 untitled RELA SKIL TGIF1-1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle OGDH SUCLG1 SDHC ACO2 PDK2 CS FH PDHA1 MDH1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1-2 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism NT5E DPYSL5 ABAT DPYSL2 DPYS DPYD DPYSL3 UPB1 CDA ALDH6A1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB1 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade MDM2-2 MDM4 PDPK1 IRS4 IGF1R GSK3B TSC2 INS;INS-IGF2 INSR TSC1 INSRR FOXO1-1 IGF2 IGF1 PIK3CA IRS1 IGF2R IRS2 FOXO3 PTEN TPTE;TPTE2 GSK3A HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway PRKACA-1 GNG2 GNG10 GNG5 GNG4 HRH2 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 ADRB3 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 GNAL ADCY2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG2 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 CRHR1 GNB1 CRHR2 POMC GNB2 CRH GNAQ GNB4 GNB3 GNB5 GNAL ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway MAPK3 APP MAPK10 KAT5 PSENEN CACNB2 MAPK7 ADAM17 PKN3 BACE1 CACNA1D CACNA1F BACE2 KLC1 MAPK6 KLC4 KLC3 KLC2 PKN2 CACNA1S MAPK4 APBA1 PKN1 APBA3 CACNB1 APBA2 MAPK15 PSEN2 MAPK14 PSEN1 MAPK12 MAPK13 MAPK11 NCSTN APH1B CHRNA7;CHRFAM7A CACNA1C PRKCG PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PRKCQ PRKCZ MAPK1 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo CXCR4 ROBO1 CXCL12 ABL1 SLIT1 SLIT3 SLIT2 NTN1 NTN3 NTNG1 NTNG2 DCC SRGAP1 NTN4 RHOC CDC42 RAC1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis NME4-1 NME2 NME3 CPS1 CAD CTPS2 CTPS1 DSCAML1 DHODH NME1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PLCG1 MAPK3 BRAF MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 RASA4;RASA4B GAB1 GAB2 RRAS SOS1 SOS2 RASA1 RASA2 PIK3R5 STAT4 STAT6 STAT5A STAT5B STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ERBB4 PEBP1 PEBP4 RRAS2 ARAF GAB3 MRAS PIK3CD PHLDB2 PIK3CB RASAL2 PIK3C2A EGFR ERBB3 PIK3CG ERBB2 PIK3C2B SPRY4 DAB2IP SPRY3 NF1 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 SHC2 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGA SERPINB2 MMP1 MMP3 FGG SERPINE1 SERPINF2 PLAUR PLAT PLG MMP9 MMP13 PLAU FGB PNAT%PANTHER PATHWAY%P05912 PNAT SLC6A3 SNAP25 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 KCNK9 SNAP29 EPB41 PRKX PRKACB-1 ADCY2 GNAI1 VAMP8 PRKACA-1 VAMP1 EPB41L1 EPB41L2 VAMP2 FLNA DRD2 VAMP3 DRD4 SLC18A2 GNAI3 STX3 ADCY7 GNAI2 GNAZ PRKAR2B PPP1CA PPP1CC PRKAR2A PPP1R1B DRD1 GNB1 DRD5 KCNK3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SHH SMO STK36 FBXW11 PTCH1 BTRC GLI1 GLI3 CREBBP MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway SLC5A7 GNG10 ADCY10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A PRKACA-1 SLC6A8 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 KCNJ3 SLC18A3 KCNJ9 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 NPL GFPT2 GFPT1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway MAPK3 ACVRL1 BMP10 BMPR2 MSTN SKIL AMHR2 CITED1 CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 GDF10 SMAD1 GDF11 SMAD4 TGFB2 JUND SMURF2 MAPK10 GDF15 TGFB3 SMURF1 GDF2 BMP8B GDF1 SMAD9 INHBB GDF3 INHBA GDF6 RRAS SMAD6 BMP7 GDF5 INHBC SMAD5 ACVR2B BMP6 ACVR2A INHBE BMP5 SMAD7 GDF7 BMP4 FOSL1 SKI BMP3 GDF9 BMP2 BMP1 GDNF TLL2 CREBBP TLL1 MAP3K7 BMPR1B NODAL BMPR1A DCP1B ATF2 MAPK14 MAPK12 MAPK13 MAPK11 TAB1 EP300 HRAS JUN MAPK9 MAPK8 NRAS MAP3K7CL MAPK1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 TFPI KNG1 THBD VWF F10 GP1BB F12 F2R GP1BA F2 GP5 ITGA2B F3 GP9 PROCR F7 F8 F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 GNA14 GSK3B GNA11 IRS1 GNB2 GNAQ GNB4 GNB3 PIK3CB GNB5 AKT2 PTGER1 FOXO4 CASP9 AKT3 GNGT1 YWHAZ AKT1 GNAI1 PDPK1 INSR FOXO1-1 GNAI3 RPS6KB1 PIK3CA GNAI2 RPS6KB2 SOS1 SOS2 GNB1 FOXO3 PIK3R5 PIK3R3 PIK3R2 PIK3R1 NRAS GNAT2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway GRM3 GRM2 CALM3;CALM1 GSK3A CREBBP GNG10 HRH1 GNG5 GNG4 GNG8 CREB3L3 CREB3L4 GNB2 CREB3L1 CREB3L2 EP300 GNGT1 GRM1 CHRM3 PRKACB-1 CHRM1 GRM5 CHRM5 PRKAR1B HTR6 PRKAR1A HTR7 ADORA3 ADORA1 PHKA1 PHKA2 MTNR1A MTNR1B ADRB2 HRH3 CLTCL1 GNAI3 HRH4 ADCY7 PHKB GNAI2 PRKAR2B PYGB PRKAR2A CLTC HTR1E CLTB CREB5 HTR1F CLTA OPRD1 HTR1D PYGM HTR1A ADRA1D HTR1B PYGL ADRA1B ADRA1A HTR4 GYS2 GNAL GYS1 GNRHR ADCY4 SSTR1 OPRM1 SSTR2 ADCY1 ADRA2C ADCY8 SSTR3 ADCY6 ADRA2B ADCY5 SSTR4 KCNJ3 SSTR5 CREB3 ADCY9 CREB1 ADORA2A ADORA2B OPRL1 ADCY3 PHKG1 GSK3B PHKG2 OPRK1 GPR50 HTR5A HTR2B HTR2A RAP1B ADRB1 RAP1A HRH2 ADRB3 GRM4 GRM7 GRM6 GRM8 ADCY2 GNAI1 CREM PRKACA-1 GNG2 DRD2 DRD4 DRD1 GNB1 DRD5 CHRM2 CHRM4 KCNJ5 KCNJ6 KCNJ9 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway PLCG1 MAPK3 MAP3K6 FRS2 FRS3 FGFR4 FGFR3 FGFR2 FGFR1 MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 PTPN6 RASA4;RASA4B SOS1 SOS2 RASA1 RASA2 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 PEBP1 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B SPRY4 SPRY3 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PIK3C3 PRKCQ RAF1 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis ASL NAGS ASS1 OTC CPS1 CAD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB5 CALML3 PDC GRK1 RHO CNGA1 GNGT1 PDE6B CALM3;CALM1 CNGA3 PDE6A RGS9 RCVRN GNG13 CNGB3 CNGB1 GNG2 GNB1 GNAT1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK15 PSMA1 MAPK3 TH SLC6A3 CCNE2 PLD2 MAPK14 MAPK12 SFN YWHAZ MAPK10 YWHAE PRKN YWHAB PPP1R8;STX12 MAPK9 PSMA7 MAPK8 PSMB10 PSMA8 PSMB7 YWHAQ PSMB3 CCNE1 PSMB1 NDUFV2 YWHAG YWHAH MAPK7 SNCA GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 ELK1 CASK GPR37L1 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 MAPK1 PSMA3 PSMA4 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway ITPR1 ITPR2 SLC5A7 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 GRIN2A CHRM3 GRIN2C CHRM1 GRIN2B GRIN2D GRIN1 PRKCG PRKCI GRIN3A PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PKN3 PKN2 PRKCZ PKN1 SLC18A3 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNAI1 PDYN GNG2 PENK GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 GNB2 GNB4 GNB3 GNB5 ADCY2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 PRIM1 RPA2 POLA1 POLD1 POLD2 TOP1 DNA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis DSCAML1 NME1 AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 RRM2B NME6 NME7 IMPDH2 ADSS1 ADSS2 RRM2-1 GART NME4-1 NME2 NME3 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13B RXRA VDR RARA GC HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway SSTR5 ADORA2A ADORA2B OPRL1 OPRK1 GRM3 GRM2 GNG13 DNAJC27 RAP1B RAP1A GRM4 GRM7 GRM6 GRM8 CACNA1E ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 GNGT1 GRM1 CHRM3 RHOA CHRM1 GRM5 CHRM5 PRKCG ADORA3 PRKCI ADORA1 PRKCH GNG2 PRKCB PRKCE DRD2 PRKCD DRD4 PRKCA CLTCL1 CLTC CLTB PRKCQ DRD1 GNB1 CLTA BDKRB2 OPRD1 DRD5 BDKRB1 GARNL3 ARHGEF1 GPR45 GNAO1 RASGRP2 RASGRP1 RASGRP4 GNRHR RAP1GAP CHRM2 SSTR1 CACNA1B RASGRP3 CHRM4 OPRM1 CACNA1A PRKCZ SSTR2 SSTR3 SSTR4 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis DOK2 DOK3 EPHA3 PLD1 GRB7 PLD2 TCF7 EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PLA2G4D PDGFRB AXIN1 PDGFRA BIRC5 GRB14-1 DLL1 DLL3 DLL4 PDGFB ANGPT1 PDGFA DLK1 APC TEK GRAP NCK2 JAK1 NCK1 RASA1 HSPB1 CTNNB1 MAP2K4 MAPK14 MAPKAPK3 F2R MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 HRAS PRKCG PRKCI PRKCH JUN PRKCB SPHK2 SPHK1 PRKCE MAPK8 PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA GSK3B FRS2 FRS3 CRKL FGFR1 AKT2 AKT3 PAK1 PAK3 PAK2 WNT2B RBPJ FOS WNT5B SOS1 WNT5A SOS2 RBPJL NOTCH2 STAT1 NOTCH1 NOTCH4 STAT3 SHC1-1 DVL1 DVL2 DVL3 WNT1 WNT2 FZD1 TCF7L2 WNT10B RHOC WNT10A FZD3 RHOA FZD2 RHOB FZD5 WNT7B WNT7A CRK MAP3K1 SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM1 RRM2B NME4-1 NME2 NME3 DTYMK DUT ADAT2 RRM2-1 TYMS DSCAML1 NME1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking LOC102724488;SYT15 STX1A STXBP1 SYT7 UNC13D VAMP1 SYT6 RIMS1 SYT12 SNAP25 SYT11 STX2 SYT5 UNC13B UNC13C SYT3 SYT2 RAB3A SYT1 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 ARRB2 BCAR1 EGR1 PPP3CA LYN CALM3;CALM1 NFKBIA MAPK10 GRB2 JAK2 CLU IER3 RPS6KB1 RPS6 RHEB PTGS2-2 CETP EIF4EBP1 ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 SRF RYR1 HSPB1 ELK1 RYR2 ELAVL1 RYR3 CD38 CTNNB1 GAST NOS1 CCKBR EIF4E AKT1S1 MEF2D PPARG HBEGF MAP2K6 GUCY2D MAP2K4 ITPR1 NR2C2 MEF2C AKAP1 HDAC7 BAD MAPK14 MEF2B;BORCS8-MEF2B PTPN11 CCK TPCN2 TPCN1 CAMK4 TRAF6 ARAF PIK3CB PRKACB-1 AKT1 RAC1 PRKCH JUN PRKCB MAPK9 PRKCE MAPK8 PRKCD BCL2 PLA2G4A PRKCA PRKD2 PRKCQ PRKD1 RAF1 PXN NFATC2 PIK3R1 ADCY1 MAP2K2;MAP2K1 MAPK1 PRKG1 PLCG1 MAPK3 CREB1 BRAF PTK2 GSK3B CXCL8 IRS1 ELK4 RPS6KA3 ODC1 ROCK1 RPS6KA1 PAK1 CDH1 PDPK1 YWHAB FOS FOXO1-1 SOS1 FOXO3 MAPK7 ITGB1 STAT3 ATF2 SHC1-1 CASP3 ITGAV RHOA CREM PRKACA-1 MMP3 GNG2 SLC18A2 PLAU CRK GNB1 SRC BAX MAP3K14 CDC42 BCL2L1 PTK2B GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GPI HKDC1 HK2 HK1 TPI1 PKLR PGAM2 BPGM ENO1 ENO2 PFKL GAPDH-1 ALDOA PKM PGK1 PFKM NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway JAG2 JAG1 DLL3 DLL4 DLK1 MAML1 NCOR2 NUMB RBPJL CIR1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 RBPJ GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ABAT ALDH5A1 GAD1 GAD2 CSAD FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway MAP2K4 FASLG CASP7 CASP8 CASP10 CASP3 DAXX MAP3K5 APAF1 CASP9 MAPK10 FAF1 CAPG LMNB2 LMNB1 SCIN CASP6 JUN LMNA DFFB MAPK9 PARP3 MAPK8 GSN PARP4 PARP1 FADD PARP2 CFLAR FAS INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway JUNB VAV1 GRAP JUND JAK2 KRAS ITPR1 ITPR2 ITPR3 MYH1 MYH3 GNA14 GNG10 MYO3B VWF MYO3A MYH8 GNG5 PLCZ1 MYH9 MYH6 GNG4 MYH7 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 ARAF GNAQ GNB3 PIK3CD MYH13 PIK3CB MYH14 PLCB1 PLCB2 MYH11 PIK3CG PLCD4 MYH10 PLCD1 MYH7B PRKX PRKACB-1 AKT1 RAC1 JUN PRKCB PRKCE GNAI3 PIK3CA PREX1 GNAI2 CCRL2 PF4;PF4V1-1 LTB4R2 CCL3L1;CCL3L3;CCL3;CCL18 RAF1 IFNAR1 CCL13;CCL2 C5AR1 FPR1 NFATC3 GNAO1 CCR10 NFATC2 CCR1 XCR1 NFATC1 NFATC4 CXCL10 PRKCZ CX3CL1 CCR9 NRAS CCR8 PLCG2 CCR7 ADCY6 CCR6 ADCY5 MAPK1 CCR5 PLCG1 CCR4 CCR3 MAPK3 CCR2 RHOG CX3CR1 NFAT5 CAMK2D CCL11 CAMK2A MYLK2 CXCL8 CXCR5 BUB1B-PAK6;PAK6 CXCR6 CCL4L2;CCL4L1;CCL4 CCL8 MYLK3 CCL5 COL12A1 MYLK CXCR3 CCL22 ARPC5L CCL21 IKBKB CCL20 CCL27 CCL26 AKT2 ROCK1 AKT3 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 ACTG1 ARPC4 CHUK PDPK1 RRAS SOS1 IFNG ARPC5 CXCR1 ARPC2 ACTA2 CXCR2 ARPC3 ACTA1 CASK ACTBL2 COL20A1 ITGB1 STAT3 CXCR4 IL2 COL14A1 ARPC1B ARPC1A SHC1-1 ITGAL ITGB7 RHOC RHOA ADCY2 GNAI1 PRKACA-1 GNG2 COL6A2 RELA COL6A1 RELB COL6A3 ACTB-1 NFKB2 CDC42 PTK2B XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway HPRT1 PNP-1 PRTFDC1 GDA HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease RHOG GRIK5 GRIK3 GRIK4 ARPC5L GRIK1 GRIK2 TUBB1 TUBB2B;TUBB2A TUBB3;TUBB6 CYFIP2 GRIN2A CYFIP1 HIP1 AP2A1 AP2A2 ACTC1;ACTG2 CAPN9 CAPNS1 GRIN2C CAPN6 GRIN2B CAPN7 GRIN2D ACTG1 CAPNS2 GRIN1 CAPN5 TUBB4B CAPN2 GRIN3A CAPN3 CAPN1 TUBB4A;TUBB;TUBB8B;TUBB8 IFT57 DYNC2H1 DNAI2 ACTR2 FOS DYNC1LI1 DYNC1LI2 RHOJ GAPDHS HAP1 RHOQ DNAH3 DYNC1I2 ARPC5 DNAH7 DCTN1 SP1 DNAH8 ACTA2 DNAH5 TP63 HTT ACTA1 KALRN CYC1 ACTBL2 DYNC1I1 DYNC1H1 BDNF HIP1R CAPN11 CAPN12 TP53 CAPN10 CREBBP DLG4 TP73 DNAL4 MAP2K4 ARPC1B ARPC1A CASP8 CASP3 MAP3K10 GAPDH-1 APAF1 EP300 TBP RAC1 JUN MAPK9 MAP2K7 ACTB-1 TAF4 CLTB CDC42 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism ACLY PC PKM ME1 PCK1 CLYBL CS PKLR PDHA1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation PLCG1 MAPK3 BRAF PPP3CA GRAP2 PPP3CB VAV3 IKBKB VAV1 VAV2 AKT2 AKT3 PAK1 PAK3 CALM3;CALM1 PAK2 NFKBIA PTPRC CHUK NCK2 NCK1 FOS SOS1 SOS2 ITPR1 CD86 CD80 CD3G CD3E CD3D PPP3CC ZAP70 LCK LCP2 CD28 CD247 LAT ARAF PIK3CD PIK3CB PIK3CG AKT1 RAC1 HRAS JUN MAPK9 MAPK8 PIK3CA PIK3C3 MAP3K1 PRKCQ RAF1 PIK3R3 PIK3R2 PIK3R1 CDC42 NRAS MAP2K2;MAP2K1 MAPK1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway MAPK3 MAPK14 TRAF6 TAB1 IKBKB ECSIT TANK TBK1 IRAK1 MAP3K8 IKBKE TICAM2 IRAK4 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TLR9 TLR8 TLR7 TLR10 MAP2K3 CHUK TLR6 JUN NFKBIE TLR4 TLR3 MAPK9 MYD88 MAPK8 TLR2 ELK1 MAP2K2;MAP2K1 MAP3K7 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway TBL1Y CTNNA3 CTNNA2 CSNK1A1 TLE4 CSNK1G3 TLE3 TLE2 TLE1 CHD1L TLE6 PYGO1 PYGO2 TBL1XR1 CSNK1G2 EP400 BCL9 PPP2R5E DACT1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A SMAD1 SAG SMARCD1 SMAD4 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 GNG13 CDH3 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 LRP5 WNT8A WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ARRB1 ARRB2 PPP3CA PPP3CB AXIN1 HDAC1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CREBBP CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 EP300 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 PRKCG FAT2 PRKCI DCHS1 PRKCH FAT3 PRKCB PCDHB3 PCDHB7 PCDHGB7 PRKCE PCDHGB6 PRKCD PCDHGB2 PCDHA8;PCDHA6-1 PRKCA PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PRKCQ PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 NFATC1 CDH15 CDH16 PRKCZ CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 GSK3B PPP3CC GNG2 SMARCAL1 SMARCB1 ARR3 SMARCC1 SMARCC2 CSNK2A2 CSNK2B GNB1 SRCAP NLK PPP3R1 HLTF SIAH2 FBXW11 SMARCA5 TPTEP2-CSNK1E;CSNK1E BTRC CSNK1D INO80 SMARCA1 SMARCA2 SMARCA4 ANKRD6 HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 CTNNA1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway ADA APRT HPRT1 PNP-1 PRTFDC1 XDH TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway STX1A CACNA1E GNG10 SNAP25 ADCY10 GNG5 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 GRM3 GNB5 GRM2 SNAP29 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A VAMP8 PRKACA-1 VAMP1 VAMP2 VAMP3 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CACNA1B CACNA1A GNAT2 CACNB1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI1 PDYN GNG2 GNG10 OPRK1 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 GNB2 GNB4 GNAO1 GNB3 GNB5 AVP OXT-1 ADCY2 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins DPYSL5 DPYSL2 DPYS NRP1 SEMA4D SEMA3A CRMP1 CDK5 DPYSL4 FES PLXNA1 PLXNB1 FRK ARHGEF1 PAK1 RHOA FYN RAC1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNAI1 CACNA1G GNG5 GNAI3 GNG4 GNG8 PLCB3 CNR1 GNB1 GNB2 GNB4 GNAO1 GNB3 PLCB1 PLCB2 CACNA1B CACNA1A GRM1 GRM5 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBPL2 TAF8 TBPL1 TTF1 PSMC3IP RRN3 CAVIN1 TAF1B TAF1C POLR1B TAF1A UBTF POLR1D TBP PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides TK1 ADAT2 CDA BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release CREB1 PDYN PENK GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 ADCY2 GNAI1 CREM PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A GNB1 OPRD1 GNAO1 GNAL OPRM1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG ITPR1 PRKCE PRKCD PRKCA GNA11 PLCE1 PLCB3 PLCB4 ADRA1B ADRA1A PLCB1 PLCB2 ADRA2A ADRA2C ADRA2B LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 NFKBIA IKBKB CD40LG TRAF3 TRAF6 IKBKG CD40 MAP3K1 CHUK INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway RALBP1-1 AKR1A1 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH CBR3 ABCG2 CBR1-1 NQO1 ABCC1 ABCB1 ABCC2 NOS3 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling ASNS GLUL ASRGL1 GLS2 GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages HRAS MAPK3 CACNA1C NFKB1 NFKBIA PRKCB ITPR1 PLCB1 CACNA1D PRKCA CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis SRM MAT2A ODC1 SMS AMD1 MAT2B ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ACADS HADH TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCB1 ABCC2 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ADH1C;ADH1B;ADH1A RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 PRKACB-1 GNGT1 CREB1 FSHR CGA PPP1CA GNAS-1 GNB1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 ACSM2A;ACSM2B GLYAT PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) CRLS1 CDS2 PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ABCC2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins PLCB1 GNGT1 TUB GNAQ CHRM1 GNB1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A FARSA RPL9 RPL6 RPL7 FARSB RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 ABCB1 CYP2E1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCG2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHB MMUT PCCA PCCB DBT SDS DLD BCKDHA METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCB1 ABCC2 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 ATP5F1A SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB GAPDH-1 SLC25A4 SLC37A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 GGCX NQO1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway CYP1A2 SCN10A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SCN1B 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP2E1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism ECHS1 HMGCL ACAT1 ACADS OXCT1-1 ACSM1 HADH CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway LSS SQLE ACAT1 FDPS IDI1 PMVK MVK MVD FDFT1 HMGCS1-1 HMGCR BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 JMJD7-PLA2G4B;PLA2G4B CDS1 GPAM DGKA PTPMT1 CHAT GPD1 GDE1 LYPLA1-1 CRLS1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C7 C9 C3-1 CFP C8A CFB CFD C5 C6 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides TYRP1 CAT SOD2 SOD3 SOD1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 TOP1 ABCC2 CES2 CES1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCB1 ABCC2 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway HRAS STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR SLC2A4 GHR SOCS1 RPS6KA1 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct ATP1A1 SLC14A2 SLC4A1 SCNN1G AQP2 ATP1B3-1 AQP3 ATP6V1B1 SCNN1D REN SCNN1B SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 CA1 ATP1A2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GAPDH-1 GPD1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD SPTAN1 MAP3K7 PAK2 DFFB MAP2K4 DAXX JUN DFFA PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway TUBB1 ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 AGXT GPT AARS2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway SLC22A6 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 PTGIS DNAJB11 GPX1 ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC9A1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 AQP1 CA1 SLC4A4 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS STAT5A EPO MAPK3 FOS ELK1 EPOR MAPK8 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 JUN MAP2K2;MAP2K1 RAF1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GLP1R CACNA1A RAB3A SLC2A2 ITPR3 CAMKK1 RIMS2 ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CACNA2D2 PRKCA CHRM3 CACNB1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 HTR6 GNB1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP2C9;CYP2C19 GRIN1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN3A GRIN2A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism SEPHS2 PAPSS1 MAT2A CBS;CBSL CTH AHCY MARS1 SLC39A8 METTL6 MAT2B SCLY GGT1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 ADCY2 PRKACB-1 GNGT1 GNAS-1 PTGDR GNB1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling ADCY1 PLCB1 LPAR4 SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway GSTZ1 DCT ACSS2 ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 FAH GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 AGXT GPT AARS2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III GALK1 GALT GCK UGP2 PGM1 UGDH GALE UXS1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway PLCB1 VAV1 PIK3CG PIK3R6 PRKCA PLCG1 AKT1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT1 NPR1 NAMPT NMNAT3 RORA NMNAT2 CLOCK PPARGC1A SIRT1 NQO1 NADK CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA HTR7 GNAS-1 GNB1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2-2 SLC22A6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC22A8 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 PRKACB-1 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 FMO3 CYP2B6 AOX1 CHRNA4 CHRNB2 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SETD7 BBOX1 ALDH9A1 SHMT1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME1 NME2 AK1 AK2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST CTNS MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway FOS ELK1 SRF GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 RASA1 PRKCA CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism AOX1 PDXK PNPO PDXP ALPL NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 MARS1 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA SLC28A1 TYMP TYMS CES1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism ENPP1 ACP1 TYR FLAD1 RFK ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ACADS HADH ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis AGPAT1 GNPAT AGPS CEPT1 PLPP1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME1 NME2 AK1 AK2 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation ATP1B3-1 ATP1A1 SLC2A2 GCK FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AOX1 MAOA MAOB SLC6A4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle SLC2A2 SLC2A4 GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PGK1 FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 TALDO1 PGD PDHA1 IDH3G RPIA IDH1 PFKL PGAM2 ENO1 PGLS SDHC SDHD HK2 SDHA TKT GAPDH-1 SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD PKLR SLC2A2 MDH1 LDHA SLC16A1 PKM ALDOB ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) DHCR7 LBR NSDHL EBP SC5D CYP51A1 MSMO1 DHCR24 HSD17B7 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway TYK2 JAK1 STAT3 MTOR MAPK1 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway OPRM1 BCHE CES2 CES1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway RALBP1-1 HRAS MAPK3 ELK1 RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CASP9 CDC42 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 CHUK AKT1 RAF1 RALGDS PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis HSD3B1;HSD3B2 CYP11B1;CYP11B2 CYP11A1 GNG2 CYP21A2 GNAQ GNB1 AGTR1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST CTNS ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling ADCY1 PLCB1 LPAR5 SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling HRAS PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System ADCY2 PRKACB-1 GNAS-1 DRD1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway EPHX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 PCNA GADD45B CCNB1 CCND1 CCNE1 CDK4 CDK2 BCL2 CDKN1A CDK1 E2F1 BAX APAF1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMC5 PSMA3 PSMA4 PSMC6 PSMC3 PSMA1 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH CYP2E1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway FOS ELK1 CD79B CD79A PPP3CA PPP3CB PPP3CC GRB2 BLNK RAC1 PLCG1 LYN SYK PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 LPAR1 SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis CEPT1 PCYT1A CHKA PCYT2 PISD PEMT HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis TOP2A CAD DFFA CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKACB-1 GNGT1 PRKACA-1 ADCY10 GNAS-1 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNB1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C7 C9 C3-1 C8A C1QB C1S C1R C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC C6 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NADSYN1 ENPP1 BST1 NNT NT5C2 NMRK1 NUDT12 NAMPT NMNAT2 NADK AOX1 PNP-1 NNMT QPRT SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL STAT5A SLC22A1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 ABCB1 CRK BCL2L1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism TPH1 ASMT KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 KYNU AFMID CYP1A1 IDO1 AADAT DDC CAT HAAO LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation MDH1 NFKB1 ACACA NFKBIA IKBKB TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA CHUK HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis ADCY2 PRKACB-1 GNGT1 FSHR GNAS-1 AVPR2 GNB1 COAGULATION%SMPDB%SMP0000586 Coagulation VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ADH1C;ADH1B;ADH1A CAT ALDH2 CYP2E1 ACSS1 ALDH1B1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) DHCR7 LBR NSDHL EBP SC5D CYP51A1 MSMO1 DHCR24 HSD17B7 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway TUBB1 ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT1 NAMPT TP53 NMNAT3 NMNAT2 SIRT1 NQO1 AIFM2 NADK CD38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer FH DLST PDHB DHTKD1 MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle ATP1B3-1 ATP1A1 REN FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1B1 SLC12A6 ATP1A4 ATP1A3 SLC12A1 ATP1A2 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway CXCR4 HRAS PIK3C2G MAPK3 PTK2 GNAI1 NFKB1 GNGT1 CXCL12 NFKBIA PTK2B BCAR1 PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK PXN RAF1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE REN AGT AGTR1 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway ALG10;ALG10B SNTB1 SNTB2 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 AGXT GPT AARS2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 NFKB1 NFKBIA IKBKB MAPK8 MAP2K3 ATF1 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 CHUK TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 HADHA CPT2 ACADL SLC25A20 HADH INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 PCSK2 CYP2B6 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 FMO3 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 AOC1 HDC PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle SLC25A11 GOT2-1 SLC25A12 MDH2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway SHMT2 MTR-1 BHMT GNMT MAT2A CHDH SARDH ALDH7A1 SHMT1 DMGDH SLC44A1 SLC44A2 MAT2B PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 C3-1 C8A C2 MBL2-1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C5 C6 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA SLC28A1 TYMP TYMS CES1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria MDH1 ACLY PDHB PC MPC1 SLC25A11 ME1 PDHA1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells INPP5D MAPK14 MAP2K3 GRB2 RAC1 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MS4A2 VAV3 MAP2K4 LAT PIK3R1 PIK3CA AKT1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism CDO1 GAD1 CSAD ADO GGT6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation RB1 TP53 BTG2 CHAF1A HOXB9 BTG1 PRMT1 NGF CCND1 FGF1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 KCNQ4 KCNQ5 ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 GUCY1A1 NOS3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway NME1 PGK1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A1 SLC22A2 ABCC4 PCYT1A SLC22A3 ABCG2 CHPT1 ABCC3 PCYT2 CMPK1 ABCC1 ABCB1 ABCC2 DCK VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 ABCB1 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) GALK1 GALT GCK UGP2 PGM1 UGDH GALE UXS1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9;CYP2C19 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A4 PNP-1 SLC2A1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL4 SARS1 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR2 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 NR1H4 SLC10A2 FGFR4 FGFR3 FGFR2 FGFR1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SNTB1 ABCC8 SNTB2 CACNA1A SLC2A2 CACNA2D2 GCG SCN5A SNTA1 CACNB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin ADCY2 PRKACB-1 GNGT1 PTGIR MYL3 GNAS-1 MYLK GNB1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 MAPK14 NFKB1 NFKBIA IKBKB TRAF6 IKBKG ECSIT RELA IRAK1 TLR1 TOLLIP TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 MAPK8 TLR5 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 TOP1 ABCC2 CES2 CES1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis PANK1 ENPP1 VNN1 PPCS COASY PPCDC METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 ADORA2A JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 AKT1 CHUK ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor PLCB1 PRKCA GNAQ ITPR1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism GALK1 GALT GCK UGP2 PGM1 UGDH GALE UXS1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCB1 ABCC2 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 AOC1 HDC PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PDE4D-1 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids ECHS1 HADHB-1 ACAA2 HADHA ACSM1 ACADM SLC25A20 HADH ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism HSD11B1 PDIA2 UGT1A1;UGT1A6 PDIA6 CYP11B1;CYP11B2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway VEGFA KDR FLT1 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway HYOU1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 CEPT1 CHKA PCYT2 PISD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A YARS1 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism IPPK PIKFYVE MIOX ISYNA1 INPP1 ITPK1 IPMK PI4KA INPP4A MINPP1 IMPA1 PIK3C3 ITPKA INPP5J PLCD3 VAC14 BECN1 PIK3R4 AMBRA1 PIK3CA PTPMT1 FIG4 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway HSD17B10 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ACADSB HADHA CYP2B6 ACSM1 IVD EHHADH-1 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1B3-1 ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTB1 SNTB2 SCN5A SNTA1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ERBB4 NRG2 PSEN1 PRKCA ADAM17 EGFR ERBB3 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway RALBP1-1 PAK1 PCNA RAC1 CCND1 CDKN1A CAP1 VAV3 PDGFRA WASF1-1 LIMK1 CCND3 CDK5 PLD1 ACTB-1 MYLK RPS6KB1 MYL2 CFL1 ARFIP2 PPP1R12B MAP3K1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway NFKB1 NFKBIA IKBKB TRAF6 IKBKG TRADD TNF RIPK1 RELA IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B TNFRSF1A IL1A TAB1 MAP3K14 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 CHUK METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CYP2B6 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 FADS1 JMJD7-PLA2G4B;PLA2G4B OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism MTR-1 BHMT MAT2A CHDH ALDH7A1 PEMT AHCY MAT2B BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A CARS1 RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 AGXT GPT AARS2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 IMPDH2 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 CES2 CES1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ADH1C;ADH1B;ADH1A RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 ADORA2B MAPK11 JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 AKT1 CHUK FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 SST LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR IRS2 SLC7A5 TSC2 TSC1 RHEB EIF4EBP1 MTOR EIF4E RPS6KB1 AKT1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4HA3 TLR4 IL1B NLRP3 HIF1A SIRT3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 OPRK1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CALML6 ADCY1 LHB CAMK2A ELK1 GNA11 MAPK14 GNRHR MAP3K2 EGR1 CGA MAP2K3 MMP2 FSHB ACTN4 GNAS-1 GRB2 MMP14 GNRH1 PRKCB SOS1 HBEGF ATF4 ITPR1 PLCB1 MAP2K7 CACNA1D PRKCA CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CACNA2D2 PLD1 CACNB1 CDC42 EGFR MAP3K1 SRC TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 FOS ELK1 MAPK14 NFKB1 NFKBIA IKBKB MAP2K3 TRAF6 IKBKG EIF2AK2 PPARA MAP2K6 ECSIT RELA IRAK1 TOLLIP TLR9 TAB2 TLR7 TAB1 MAPK8 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP JUN CD14 TLR4 MYD88 MAP3K1 CHUK CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis CRLS1 CDS2 PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway FOS ELK1 NFKB1 NFKBIA PPP3CA PPP3CB PPP3CC GRB2 RAC1 PLCG1 PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CD3G CALM3;CALM1 CD3E NFATC4 CD3D RASGRP1 ZAP70 LCK PTPN7 CD247 PRKCA RELA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 PIK3CG MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 XDH TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 IMPDH1 AOX1 GMPS FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNA1C CACNA2D2 CACNB1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PTK2B P2RY2 PRKCA PLCG1 PRKCB MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway CALM3;CALM1 NOS1 PRKACB-1 GRIN1 GRIN3A PPP3CA XDH DLG4 PRKCA ALDH2 GRIN2A ITPR1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia AOX1 PDXK PNPO PDXP ALPL PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST CTNS BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) NR1H4 SLC10A2 ABCC4 GPBAR1 SLCO1A2 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 HACL1 ALDH2 PHYH-4 ABCD1 SLC25A20 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production PRKACB-1 GNGT1 POMC GNAS-1 MC2R GNB1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling ADCY1 SRF GNAS-1 GNG2 ROCK1 LPAR6 GNB1 AKT1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC6A2 SLC6A4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin LHB ADCY2 PRKACB-1 GNGT1 CREB1 CGA PPP1CA GNAS-1 GNB1 LHCGR LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1B3-1 ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis LPIN1 AGPAT1 GPAM DGAT1 GPD1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation ALDH8A1 DLST DHTKD1 ACMSD DLD BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism INPP4B IPPK NUDT3 ISYNA1 PPIP5K1 INPP1 IP6K1 ITPK1 IPMK INPP4A MINPP1 IMPA1 ITPKA INPP5J ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP1A1 SLC8A1 TRPV5 CLCNKA;CLCNKB SLC12A3 AQP2 ATP1B3-1 AQP3 REN FXYD2;FXYD6-FXYD2 ATP1B2 ATP4B ATP1B1 ATP1A4 ATP4A ATP1A3 ATP1A2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation MAPK3 NFKB1 CREB1 SUCNR1 IKBKB IKBKG PLCB1 MAPK11 PTGS1 PRKCA MAPK1 CHUK NOS3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway PRF1 ARHGAP5 ARHGAP32 CASP8 CASP1 CASP10 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ADCY2 PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HRH2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling ADCY1 PLCB1 GNAS-1 GNG2 LPAR3 GNB1 ITPR1 AKT1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PRKCB FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 REL NFKBIE NFKBIB CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2A;ACSM2B SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR3C2 PIAS1 NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PPARG PGR PPARA PIAS4 HDAC4 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) POLD2 RBBP8 ATRIP BARD1 XRCC2 XRCC3 RPA1 RPA2 PALB2 SLX1A;SLX1B POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 ATM RAD1 RAD9B RAD9A ATR UBA52 RPS27A UBB;UBC SEM1 MUS81 MRE11 BRCA1 BRCA2 KAT5 EME2 EXO1 CHEK1 POLK NBN TOPBP1 POLE POLH GEN1 RFC5 RMI2 RFC3 RFC4 RFC1 RMI1 RFC2 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 RTEL1 BLM C1orf112 EME1-1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells SH3GL3 SH3KBP1 SRC CTNND1 RPS27A STAM UBB;UBC CBL CDH1 HGS CTNNB1 STAM2 MET EPS15 CBLL1 SH3GL2 SH3GL1 UBA52 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs MAP2K2;MAP2K1 MAPK1 RALGDS HRAS MAPK3 NTRK1 KIDINS220 BRAF FRS2 MAPK14 RALA-1 NGF MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK SHC1-1 SHC2 SHC3 RALB YWHAB CRKL NRAS RAP1A DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle SLC25A15 CPS1 ARG1 ASL NAGS NMRAL1 ASS1 OTC HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling SIRT1 HBA2;HBA1 NCOR1 TBL1XR1 CARM1 RORA MAFK TLR4 CLOCK NFE2L2 RXRA PPARA ATF2 SLC46A1 CRTC2 SMARCD3 CRTC3 HDAC3 CHD9 CRTC1 LY96 HBD;HBB BACH1 NPAS2 ARNTL HELZ2 RAI1 PGRMC2 XPO1 TGS1 NRIP1 EP300 HMOX1 CLEC1B APOB PPARGC1A MEF2D NCOA1 MED1 NCOA2 MEF2C CREBBP NCOA6 APOA1 NR1D1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) PSMD8 IKBKB PPP3CA PSMD6 PPP3CB PSMD7 PSMD2 PPIA PSMD3 RASGRP1 PSMD1 RASGRP3 IKBKG PPP3R1 BTRC NFATC3 MAP3K7 NFATC2 SKP1 NFATC1 CHUK CALM3;CALM1 PRKCB FKBP1A FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 REL NFKBIE NFKBIB NRAS HRAS DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 YWHAE CAST APP JUN FASLG CDC25C SOD2 FOXO3 CDC25A LMNB1 CDC25B GOLGA2 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC44A5 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 SLC44A2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer NOTCH1 CUL1 RBX1 SKP1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) GNB1 GNB4 GNB3 GNB5 VIP RAMP1 GLP1R VIPR1 WNT2B VIPR2 SCT IHH ADM FZD10 PTH1R ADGRE1 GNGT1 CRHBP SHH UCN3 ADGRE5 ADGRE3 GLP2R WNT5A WNT9B PTH2R WNT9A WNT16 GNAS-1 GIP ADCYAP1 SMO CRH IAPP CALCA ADCYAP1R1 RAMP2 CALCRL RAMP3 GIPR PTH DHH WNT8A WNT8B CRHR1 PTHLH GHRHR WNT6 GNG10 WNT11 CALCR GNG2 GNG5 GNG4 GNG8 WNT1 WNT2 CD55 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD4 WNT3A PTCH1 CALCB;CALCA GCGR WNT7B FZD7 FZD6 PTCH2 SCTR FZD9 FZD8 WNT7A GCG GNG13 GNB2 ADM2 GHRH REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs SPRED3 PSMD8 SPRED2 RASA4;RASA4B SPRED1 PSMD6 PSMD7 SYNGAP1 PSMD2 RASA3 PSMD3 RASA1 PSMD1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 DAB2IP NF1 KBTBD7 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NRAS HRAS GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis GAD1 GAD2 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB IDUA HEXB NCAN HEXA BGN GLB1L3 DCN GLB1L2 BCAN DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RB1 CDKN1C CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 DAXX ATRX TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants FLT3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion PLK1 CCNB1 CDK1 ERCC6L NUP107 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 C1orf112 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells PRL DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) MSH6 MSH2 MSH3 PMS2 MLH1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors OXTR AVPR1B AVPR2 AVP AVPR1A OXT-1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS PTDSS2 PTDSS1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins DSP CDH1 TJP1 CASP3 CTNNB1 OCLN-1 DSG1 PKP1 DSG2 DSG3 TJP2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin FDX1 FDXR DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family CTLA4 RAC1 TEAD1 TEAD2 JAK1 TEAD3 HLA-DPA1 TEAD4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 CSNK2A1;CSNK2A3 AGO3;AGO1 DERL3 DERL1 DERL2 PAK1 OS9 SPOP RICTOR PAK3 PAK2 BRD4 SUZ12 H2BC5 STAT1 STAT3 MIB2 H2BC1 FOSB VCP-1 CD86 TUSC3 CD80 LOC102723996;ICOSLG GRAP2 MAP3K8 NEK2 H2AC4 MYCN TMEM258 CD274 KMT2A KMT2C TCF7 SEL1L BTLA CTNNB1 THEM4 TNFRSF14 OST4 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B MAP3K14 RNF185 PRR5 GSK3B DPY30 PIK3CD PIK3CB PIK3CG H2BC21 WDR5 MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 DDOST PIK3CA DAD1 LCK IRF1 PRKAA1 PRKAA2 LEF1 HLA-DQB2;HLA-DQB1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN CSK RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C CD4 H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 PDCD1 TNRC6B EP300 CREBBP NFE2L2 JUN RBX1 CUL3 CCND1 CDK4 PPP2R1B PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 H2AC14 AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A2 PRKAB1 CSNK2B TRIB3 ATF3 RPN2 EPAS1 MAPKAP1 RPN1 PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 PIK3R5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN WWTR1 JUND YES1 ERLIN1 ERLIN2 MOV10 AGO4 H2AC20 AGO2 CD28 H2AB2;H2AB3;H2AB1 EZH2 HLA-DPB1-1 PRKAG1 PRKAG2 CD3G ASH2L MAGT1 CD3E CD3D PRKAG3 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 CCNK CCNT1 ELL GTF2B ELOC-1 TAF7L ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H TBP NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane GJA1 GJB2 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding GNB1 GNB4 GNB3 GNB5 CSNK2A1;CSNK2A3 DCAF7 CCT6B PFDN4-1 TUBA1C TUBA1A KIF13A TUBB1 FBXO4 LONP2 FBXO6 RGS9 STAT3 RGS6 RGS7 FBXW4 CCT3 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 TUBA4A XRN2 TCP1 GAPDHS PFDN1 PFDN2 FKBP9 TP53 PFDN5 TUBB3;TUBB6 PFDN6 TUBAL3 GBA ARL2 GNA14 AP3M1 GNA15 GNGT1 CCNE2 GNA11 CCT8 CCNE1 TUBA3E;TUBA3C-1 CCT7 CCT5 CCT4 NOP56 ARFGEF2 TBCD TBCC TBCB TBCA TUBB4B CCT6A TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 GNAQ TBCE PDCL SKIV2L FBXL3 RGS11 FBXL5 TUBA8 WRAP53 CSNK2A2 CSNK2B GNG10 GNG2 GNG5 GNG4 GNG8 HDAC3 GNG13 GNB2 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins NUP107 NUP43 RANBP2 NUP205 NUP188 PSIP1 AAAS NUP42 NUP62 NUP160 TPR BANF1 NUP88 RAE1 KPNA1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 SEC13 NUP133 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components CDC23 MAD2L1 UBE2S CDC26 CDC16 BUB1B CDC27 ANAPC4 CDC20 ANAPC5 BUB3 ANAPC1 ANAPC2 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation ORC1 MCM8 ORC3 ORC2 CDK1 ORC5 ORC4 CCNB1 ORC6 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions GJD2 GJC1 PANX1 PANX2 GJA10 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 KPNA7 RPL35 RPL38 KPNA5 KPNA2 RPS11 KPNA3 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPL10;RPL10L-1 KPNA4-1 CPSF4 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 CLTC CLTA RPS4X RPL7A NUP107 GBP2;GBP3;GBP1 RPLP2 RPL36-1 HSP90AA1 PARP1 RPS3A DNAJC3-1 CANX RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A PABPN1-1 RPL22L1 FAU NUP160 RAN RPL26L1 NUP85 RPS27 XPO1 SEC13 NUP133 NUP43 RANBP2 UBA52 NUP37 RPS27A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 NUP205 NUP188 AAAS NUP42 NUP62 TPR NUP88 RAE1 KPNA1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SLC25A6 RPL4 RPL30 RPL3 CALR-1 RPL32 HSPA1A;HSPA1B RPL31 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS ALG14 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling ELF2 CBFB PAX5 RUNX1 BLK ELF1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism PANK4 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 NUDT8 VNN2 PPCS PDZD11 FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript NXF2;NXF2B;NXF5-1 THOC1 THOC3 THOC2 THOC5 CDC40 NCBP2-1 THOC7 THOC6 NUP43 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 RANBP2 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A POLDIP3 SRSF1 NXF1 U2AF2 FYTTD1-1 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NUP37 NUP107 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 NCBP1 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 GLE1 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate SOX2 ZEB2 SOX1 FGF8 GBX2 OTX2 TBX6 POU3F1 ZNF521 WNT3A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis AGO4 AGO2 TSNAX PRKRA DICER1 TARBP2 AGO3;AGO1 TSN TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPV2 TRPV3 TRPV1 MCOLN1 TRPC4AP MCOLN2 TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 B2M AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 POMP PSMB10 PSMA8 PSMF1 PSMB8 PSMB9 PSMG3 PSMG4 PSMG1 PSMG2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation TAB2 TAB1 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 RASGRP1 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 UBE2D1 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PDPK1 LYN CDC34 TRAF6 PRKCQ UBE2V1 RASGRP2 RASGRP4 UBE2D3;UBE2D2 UBE2N TAB3 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity SIRT1 CSF1 MC4R HINT1 EDNRB QARS1 RPS6KA1 ZIC1 TNFSF11 SOX9 YWHAH FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB PAX3 YWHAE MITF SOX10 POU3F2 YWHAZ DARS1 MC3R LARS1 TFEC KIT EEF1E1 HDAC1 KARS1 ALX3 IARS1 SOX2 MARK3 TBX3 POMC AIMP1 AIMP2 MC1R EPRS1 ID1 MC5R SNAI2 CDH1 CTNNB1 YWHAB GSK3B MAPK1 UBE2I MAPK3 YWHAG SUMO1 LEF1 AKT3 XPO1 WNT3A EP300 CREBBP THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis CAV1 DIO1 DIO3 TXNDC11 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME GSTA3;GSTA1 NME1 RAC1 VAV2 IMPDH1 GUK1 IMPDH2 HPRT1 GSTA3;GSTA5;GSTA1;GSTA2 NUDT15 SLC28A2 SLC29A1 VAV1 XDH SLC28A3 SLC29A2 VAV3 ABCC4 TPMT ABCC5 NME2 GMPS GSTM1;GSTM2-1 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle HSP90AA1 SRRM1 CCT6A DDX39B HSP90AB1 CUL3 ROCK1 ROCK2 GPS1 TWF1 MSI2 RHOBTB1 RHOBTB2 ACTG1 TRA2B STK38 MYO6 RBBP6 SPEN RNF20 CPSF7 ACTN1 TMOD3 TXNL1 COPS4 CCT2 CDC37 COPS2 PDE5A PHIP HNRNPC VIM RBMX DBN1 CCT7 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM3 MCM8 MCM4 MCM5 MCM6 MCM2 GINS1 GINS2 CDC45 MCM7 GINS3 GINS4 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing FURIN PCSK6 PCSK5 NGF LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1-1 TGFBR2 TGFB1 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD AKT1S1 CAB39 EIF4EBP1 PGK1 SLC38A9 EIF4E EIF4B RHEB AGO3;AGO1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 FKBP1A LAMTOR5 EIF4G1 RPS6 YWHAB MLST8 PRKAA1 PRKAA2 AKT2 AKT3 AKT1 PRKAB2 PRKAB1 TNRC6A-1 MTOR TNRC6C TNRC6B MOV10 AGO4 AGO2 PRKAG1 PRKAG2 CAB39L RPTOR STK11 EEF2K STRADA PRKAG3 STRADB DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy ACY1;ABHD14A-ACY1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity SNAP25 SV2C SYT2 SV2B SYT1 SV2A VAMP1 STX1A VAMP2 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated APC TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters SLC34A2 SLC34A1 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CHUK IKBKB IKBKG REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) TBL1XR1 CARM1 TM7SF2 HMGCS1-1 GGPS1 ELOVL6 LSS SREBF2 MTF1 MVD KPNB1 IDI1 SEC23A MVK SAR1B INSIG2 INSIG1 ACACB ACACA PMVK SC5D SCAP FDFT1 FDPS MBTPS1 SEC24B SEC24A NFYB NFYC CYP51A1 SEC24D-1 SQLE GPAM SP1 SCD NFYA-1 DHCR7 SEC24C MBTPS2 RXRA PPARA RAN SMARCD3 CHD9 HELZ2 TGS1 FASN NCOA1 MED1 NCOA2 CREBBP NCOA6 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor CALM3;CALM1 DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell SH3GL3 SH3KBP1 RPS27A STAM UBB;UBC CBL HGS STAM2 MET EPS15 SH3GL2 SH3GL1 UBA52 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBA52 RPS27A UBB;UBC REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis FASLG UBA52 RPS27A UBB;UBC MLKL CASP3 TP53 HSP90AA1 IRF1 TRADD CASP8 CASP1 FLOT1 TNFSF10 FLOT2 TP63 GZMH;GZMB-1 PDCD6IP RIPK3 IL18 TRAF2 IL1A IL1B IRF2 CHMP4C PELI1 CHMP4B CHMP3 CDC37 CHMP4A TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CHMP6 CHMP7 BIRC2 BIRC3 PRKN XIAP CYCS-1 SDCBP HMGB1-1 RIPK1 OGT-1 BAK1 FADD ELANE GSDMD CASP5;CASP4 ITCH CHMP2B CHMP2A FAS BAX STUB1 GSDME DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway FYN SH3KBP1 RELN DAB1 VLDLR CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation ATP5MC3 MICOS13 MICOS10 ATP5MC1 APOO ATP5F1A ATP5F1B CHCHD3 SAMM50 CHCHD6 ATP5MJ ATP5MG ATP5ME DMAC2L HSPA9 ATP5PF ATP5PD APOOL MTX1 ATP5PB MTX2 DNAJC11 IMMT ATP5F1C ATP5F1D TMEM11 ATP5PO ATP5MC2 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex POLD2 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 WDR48 UBA52 USP1 UBE2B DDB1 CUL4A DTL POLE RAD18 CUL4B RFC5 RFC3 RFC4 RFC1 RFC2 RPS27A UBB;UBC RBX1 PCNA POLD3 POLD4 POLD1 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis CALM3;CALM1 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 RYR3 SLC8A1 SLC8A2 PRKACA-1 NOS1 CLIC2 ABCC9 ATP1B2 ATP1B1 TRDN ASPH STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ITPR2 ATP1A3 ATP1A2 TRPC1 ITPR3 SRI ATP1A1 TNNI3 CAMK2G KCNJ11 DMPK ATP1B3-1 ATP2B4 ATP2B3 FXYD2;FXYD6-FXYD2 ATP2B2 ATP2B1 SLC8A3 FXYD4 FXYD3 FKBP1B FXYD1 FXYD6 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RB1 FZR1 ANAPC15 SKP2 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence RPS6KA1 FOS RAD50 H2AJ AGO3;AGO1 ATM ANAPC15 ANAPC16 ANAPC7 UBE2C SUZ12 UBE2E1 H2BC5 UBE2D1 ANAPC10 STAT3 ANAPC11 H2BC1 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 H2AC4 ANAPC2 ID1 RB1 CDKN1A CDKN1B FZR1 E2F1 E2F2 E2F3 TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 MAPK14 MAPK11 MAPKAPK3 EHMT2 MAPKAPK2 EHMT1 ETS1 ETS2 RPS6KA3 RBBP4 RPS6KA2 MAP3K5 MAP2K3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MAP2K4 TINF2 ERF RBBP7 MAPKAPK5 TNIK ASF1A TNRC6A-1 MDM2-2 TXN EP400 TNRC6C IGFBP7 MAP2K7 H2BC15;H2BC3;H2BC11;H2BC12 MAP2K6 CBX8 CBX6 TNRC6B PHC2 ACD PHC1 CBX4 CBX2 HMGA2 H1-0 PHC3 H1-3 H1-2 H1-5 H1-4 IL6 MDM4 CXCL8 BMI1 CABIN1 CCNA2-1 KDM6B RING1 MINK1 TERF2 CCNA1 POT1 TERF2IP CEBPB RNF2 HIRA MAPK9 MAPK8 MAPK7 UBN1 MAP4K4 CDKN2D CDKN2B IFNB1-4 CDKN2C CDKN2A MAPK10 TERF1-1 JUN UBA52 LMNB1 RELA RPS27A UBB;UBC NFKB1 TP53 SP1 H2AC14 MRE11 KAT5 IL1A NBN H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MOV10 AGO4 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RB1 CDKN1C CDKN1A CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) PTPN11 RAC1 CDK5 HRAS PIK3R1 FRS2 CDK5R1 PIK3CA SRC NTRK2 DOCK3 BDNF GAB1 GRIN2B SOS1 FRS3 NTF4 TIAM1 NTF3 PLCG1 NRAS NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes NOTCH1 SP1 EP300 MAFK NFE2L2 EGF BCL2 CREBBP PDGFA AREG BCL2L1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 EEF1B2-1 RPL23 RPS5 EEF1G RPL22 EEF1A1 RPS6 EEF1D RPSA EEF1A2 RPL24 EEF2 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 RPL4 RPL30 RPL3 RPL32 RPL31 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) TSC2 TSC1 AKT2 AKT3 AKT1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 RPS27A UBB;UBC NOTCH1 UBA52 MIB2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling PIK3CD PIK3CB PIK3CG MLST8 PDPK1 PIK3CA LCK AKT2 RICTOR AKT3 AKT1 FYN TRIB3 MAPKAP1 MTOR CD86 PIK3R3 CD80 PIK3R2 PIK3R1 PIK3R6 MAP3K8 PIK3R5 THEM4 CD28 MAP3K14 PRR5 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly NCBP2-1 NUP43 RANBP2 NUP37 GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 SMN2;SMN1 CLNS1A GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX20 SNRPE-2 SNRPG-2 SNUPN NUP107 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 TGS1 SEC13 NUP133 NCBP1 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives ALOX5 PTGS2-2 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ11 KCNJ8 ABCC8 ABCC9 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 C5 C3-1 LOC110384692;C4A;C4B_2;C4B CFB C2 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion GUCY2C PNLIPRP1 MGAM TREH GUCA2B CEL ALPG;ALPP;ALPI-1 GUCA2A LIPF CHIT1 CLPS SI PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B LCT PNLIP RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2S3;EIF2S3B EIF2B1 EIF2S1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CDKN2A ATM PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CDKN1A RPS27A CDKN1B UBB;UBC ADRM1 PSMA2-1 TP53 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CCNE2 CCNE1 CDK2 MDM2-2 PHF20 CHEK2 ZNF385A COP1 PCBP4 MDM4 CCNA2-1 CCNA1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity CUL1 RBX1 SKP1 MAFK SKP2 FBXL17 BACH1 UBA52 RPS27A UBB;UBC SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC36A1 SLC38A1 SLC6A19 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC3A2 SLC1A4 SLC7A11 SLC1A5 SLC7A10 SLC1A6 SLC6A20 SLC7A1 SLC1A7 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein CANX DDOST DAD1 ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 RPN2 ST3GAL3 ST6GAL1 EDEM2 RPN1 MOGS TUSC3 GOLGA7-1 MGAT4C ZDHHC9 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 TMEM258 OST4 OSTC STT3A STT3B MAGT1 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK2G DLG1 DLG3 DLG4 ACTN2 GRIN2C PPM1E PPM1F GRIN1 GRIN2D GRIN2A DLG2 CALM3;CALM1 CAMK4 NEFL GRIN2B CAMK1 CAMK2B CAMK2D CAMK2A CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response IL6 IL10 FURIN CD163 PLK2 RHBDF2 MYH9 MAPK14 ADAM17 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site CANX CALR-1 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway TAB2 MAP3K7 TAB1 TRAF6 TIFA ALPK1 UBA52 RPS27A UBB;UBC TAB3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex CDC23 MAD2L1 UBE2S CDC26 CDC16 BUB1B CDC27 ANAPC4 CDC20 ANAPC5 BUB3 ANAPC1 ANAPC2 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway CNOT2 CNOT3 RBBP8 ATRIP ZNF777 BARD1 ZNF775 CNOT8 CNOT9 RPA1 ZNF774 RPA2 ZNF426-1 ZNF772 ZNF771 ZNF770 SIN3B RAD50 SIN3A RAD51 RPA3 ZNF529 LBR ZNF75D RAD17 ZFP90 ZNF75A ATM RAD1 ZNF514 RAD9B ZNF750 RAD9A HDAC5 SMARCD1 ATR ANAPC15 HDAC2 ANAPC16 SMARCD2 ANAPC7 RNF34 UBE2C GLS2 NLRC4 UBE2E1 HDAC8 UBE2D1 HDAC9 ANAPC10 HDAC6 ANAPC11 HDAC7 CCNB1 ZNF746 CDC23 RFFL UBE2S ZNF740 CDC26 SMARCE1 CDC16 KCNIP3 CDC27 TXNRD1 CDK1 KLF4 ANAPC4 PML ANAPC5 TP53RK ANAPC1 HDAC10 ANAPC2 HDAC11 ZNF606 ZNF605 SRC RUNX3 ZNF839 ZNF555;ZNF57;ZNF556 ZFPM1 TWIST2 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 NUAK1 CTNNB1 TP53BP2 MET BANP GADD45A TPX2 CITED1 CITED2 CITED4 INS;INS-IGF2 PRMT6 YWHAB PRMT1 GP1BA COX7A2L-1 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 MAPK1 NPY ARNT2 STEAP3 MAPK3 LMO1 ZNF197;ZNF660-ZNF197 LMO2 KCTD1 MAPK14 ATP1B4 LIFR KCTD6 FANCD2 ZNF124-4 MAPK11 NOP2 COX7A2 NPM1-2 PMAIP1 SMAD1 SMAD4 CBX5 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 TP53I3 JMY KDM5B ATF2 THRA YBX1 NR2E1 SMARCD3 CASP6 CASP2 HDAC3 CTSV;CTSL AXIN1 OPRM1 ARID1A ARID1B RBL2 RBL1 ARNTL IFNG NR2C2 THBS1 HSPD1 XPO1 ERBB2 HES1 ZNF286A EP300 ZNF189 ZNF184 ZNF180 OPRK1 PPARGC1A ARID3A DEK MED1 MEF2C CREBBP NR1D1 SIRT1 NCOR1 TBL1XR1 CARM1 NFATC2 CALM3;CALM1 YWHAE JUN FASLG CDC25C SOD2 FOXO3 PRDX2 BCL2L11 CDK5 PRDX1 CDK5R1 NOTCH1 RBX1 IHH CRH GAD1 GAD2 RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 SKP2 DAXX TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 PPP2R1B PPP2R1A PPP2CB;PPP2CA PPP2R5C BIRC5 AURKB MSH2 PMS2 MLH1 TJP1 OCLN-1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 H2AC14 AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A2 PRKAB1 CSNK2B MAPKAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 WWTR1 YES1 MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 TEAD4 FOS H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 RICTOR SUZ12 H2BC5 STAT1 H2BC1 H2AC4 KMT2A KMT2C TCF7 PRR5 GSK3B DPY30 H2BC21 WDR5 MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 PRKAA1 PRKAA2 LEF1 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B CCNK CCNT1 ELL ELOC-1 TAF7L ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H TBP CTDP1 TAF9 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TP53 TGFB1 PARP1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 SOX2 ZNF521 TRPC3 PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYB NFYC GPAM SP1 NFYA-1 CASP1 TP63 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CYCS-1 ITCH FAS BAX STUB1 PRKACA-1 CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 MDM2-2 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM4 BMI1 CCNA2-1 RING1 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PRMT5 PHF20 CHEK2 ZNF385A PCBP4 GRIN2A CAMK4 PLK2 MDC1 SPI1 NOC2L RBPJ TGIF1-1 ZNF287 ZNF18 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 CLDN5 SCO2 DDIT3 DDIT4 TXNIP MEAF6 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 CCNC-1 SFN ZNF268 PPARGC1B PRELID3A ZNF263 ABCA6 NR2F1 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF496 CBX3-1 ZNF250 UCMA ZNF45 MED16 MED15 BBC3 MED17 MED12 MED14 MED13 HEY1 CASP10 MED10 HEY2 ZNF41 ZNF248 ZNF485 ZNF483 CNOT6L ACTL6B ACTL6A MED27 MED26 DDB2 SIRT3 MED23 MED25 MMP13 MED24 MED20 ZNF235 PPARD ZNF473 SERPINB13 ZNF470 HTT EGFR PLAGL1 SPP1 ZNF226 BID ZNF222 MBD3 USP9X ATAD2 CR1L;CR1 ZNF669;ZNF670 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 CENPJ AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 RORC RORB YY1 SESN3 SESN2 ZNF689 ZNF205 KMT5A ZNF688 ZNF446 ZNF445 PITX2 ZNF202 ZNF200 BNIP3L ZNF160;ZNF347;ZNF665-1 ZFP69B FOXP3 NPAS4 MAF PVALB ZNF432 KMT2D GRIA2 MAX DLX5 DLX6 KMT2B FOXO4 SOCS3 ATXN3 MED30 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 BCL2L14 SOCS4 ZKSCAN1 ZNF420 ZNF662 ZNF660 BRPF1 FBXO32 G6PC1 RGCC ZNF419 ZNF658 ZNF416 PIN1 SP7 ZNF655 TFAP2E;TFAP2B PPP1R13B COX4I1 COX4I2 PTEN ITGAL PPP1R13L ZNF649 DGCR8 YAF2 ZNF641 NKX3-2 TRIM63 ITGA4 APAF1 TNFRSF18 ARNT ZKSCAN7;ZNF852 RABGGTB RABGGTA RRM2B ZNF264;ZNF805-1 HAND2 ITGA5 SRF PPM1D TP53INP1 ZNF624 E2F5 ZNF621 E2F6 E2F7 E2F8 ZNF747;ZNF764 PTPN1 NDUFA4 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 ZNF613 PTPN4 TRIM33 SMARCB1 UXT LGALS3 TRIM28 EPC1 CCN2 SMARCC1 SMARCC2 ZFP1 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 L3MBTL2 FOXG1 TGFA ZNF707 ZNF706 ZNF704 ZNF703 HIVEP3 APOE PCK1 CRADD IQSEC3 SMARCA2 SMARCA4 SNW1 ITGBL1 TP73 COX7B MSTN HNF4G COX7C CTSK HNF4A COX8A SREBF1 PBRM1 COX8C FOXO1-1 BRPF3-1 SATB2 COX5B COX5A RXRB ZFP14 PERP RXRG COX6C GCK VEGFA TTC5 CCNG2 CCNG1 MED31-1 MAMLD1 ZFP28 PRDM1 COX6A1 COX6A2 ZNF274;ZNF74 NPPA ARID2 G6PD MSX2 COX6B2 GEM COX6B1 GPRIN1 ZNF354A;ZNF354B-4 SMYD2-1 NDRG1 IRAK1 SMAD2;SMAD3 ZNF324B;ZNF324 TFAP2A ZFHX3 TFAP2C TFAP2D AUTS2 CNOT10 IL2 IL3 BMP2 CNOT11 DYRK2 LDB1 CHD4 CHD3 PIDD1 YWHAQ MYBL2 RBM14 TGIF2 CAT TMEM219 RETN AURKA MTA2 ZNF804B REST KRAS ZNF175 MAML2 MAML1 SERPINE1 GLS SGK1-1 MYB NAMPT PIP4K2A PIP4K2B JUNB RNF111 GAMT PRDM7;PRDM9 MED8 MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 E2F4-1 ZNF394 NEDD4L PSMD8 NKX2-5 NR2C2AP PSMD6 PLK3 PSMD7 NFE2 PSMD2 PRELID1 PSMD3 ZNF383 PSMD1 ZNF382 ZNF140 SETD1B SETD1A CDC7 SKP1 NR1D2 PRKCB ZNF699-7 CDK12 CDK13 PSMC2-1 PSMA5 ZNF135 PSMA6 ZNF133 PSMA3 RET PSMA4 GPI PSMA1 BTG2 UBA52 RARG BTG1 PSMD12 SETD9 PSMD11 CHM PSMD14 ZNF568-3 PSMD13 GLI3 GLI2 CUL1 UBE2D3-1 RELA ING5 PSMA7 ING2 PIP4P1 PSMB6 AIFM2 PSMB7 RSPO3 PSMB4 TNKS1BP1 PSMB5 ZIK1 PSMB2 BRD2 PSMB3 BRD1 PSMB1 TCF12 RPS27A NCOR2 UBB;UBC KAT2B KAT2A ADRM1 NFKB1 TAL1 RARB PSMA2-1 ZNF599 SEM1 ZNF114 PSMC5 RRM2-1 PSMC6 ZNF597 PSMC3 ZNF112 PSMC4 GPS2 PSMC1 BRD7 ZIM2 ZNF584 ZNF583 WWOX TIGAR ZNF582 PCGF6 HDAC4 PCGF5 UBE2I PCGF2 WWP1 THRB VDR HIPK1 NR1H2 POU4F1 RORA POU4F2 NR3C1 HIPK2 RYBP ESR1 ZNF334 NR2C1 ZNF573 ZNF331 CSF2 NR4A2 NR5A1 ZNF570 AR ITGA2B RXRA YEATS4 SUMO1 ZFP30 ZNF569 ZNF567 RARA ZNF566 PPARG ZNF565 ZFP37 PGR PPARA ZNF563 MEN1 MRE11 IGFBP1 BRCA1 USP7 PF4;PF4V1-1 IGFBP3 KAT5 USP2 EXO1 ZNF302;ZNF181 NRBP1 CHEK1 KAT6A NBN ZNF317 ZNF311 TOPBP1 FKBP5 ZNF793 NOTCH2 CSF1R RFC5 RMI2 ZNF792 NOTCH3 RFC3 ZNF791 RFC4 NOTCH4 RMI1 KRBA1 ZNF549 RFC2 ZNF548 TOP3A HUS1 ABL1 ZNF304 ZNF546 ZNF786 RAD51D SKIL PLXNA4 DNA2 RHNO1 ZNF300 ESRRA BLM FANCI ZNF782 ESRRB PCNA ESRRG FANCC CNOT4 CDK8 WRN CNOT6 BRIP1 ZFP69 CNOT7 BCL6 CNOT1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF MAP2K2;MAP2K1 JAK2 MAPK1 BRAP FGB HRAS CAMK2G FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B MAP3K11 VCL FN1 CALM3;CALM1 CSK MARK3 SRC KRAS CAMK2B CAMK2D ITGB3 CAMK2A ARAF PEBP1 ARRB1 YWHAB PHB IQGAP1 ARRB2 NRAS RAP1B RAP1A BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins LTA4H ALOX5 HPGD XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics ARNT2 ARNT CYP2D6;LOC107987479;LOC107987478-1 CYP2J2-1 CYP2C9;CYP2C19 CYP2C18-1 AHR CYP2W1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP2F1 IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport SKP1 UBA52 STEAP4 TFRC CUL1 HFE SLC40A1 TCIRG1 HEPH SLC22A17 FTH1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 GLRX3 RPS27A ATP6AP1 UBB;UBC SLC11A2 TFR2 ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ABCG2 ATP6V1B1 ATP6V1A IREB2 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D HMOX2 ATP6V1C1 ATP6V1C2 ATP6V0A1 MCOLN1 STEAP3 ATP6V1F FTL-1 CYBRD1 CP TF ATP6V0E2;ATP6V0E1 LCN2 ACO1 FBXL5 SLC46A1 HMOX1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 UBE2S CDC26 CDC16 CDC27 PSMA7 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CCNE2 CCNE1 CDK2 CDC6 CCNA2-1 CCNA1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN NLRP4 DTX4 ZBP1 TBK1 IRF3 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPAS1 EP300 HIF1A CITED2 ARNT EPO VEGFA CREBBP CA9 HIGD1A BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDHB DBT DLD BCKDK BCKDHA COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization COL4A3 COL4A6 COL20A1 COL9A1 COL8A2 COL8A1 COL6A3 COL4A5 COL21A1 COL9A3 COL6A6 COL6A5 COL9A2 COL1A1 COL1A2 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL12A1 COL11A2 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL3A1 COL2A1 COL5A1 COL4A2 COL4A1 COL7A1 COL6A2 COL5A3 COL4A4 COL6A1 COL5A2 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism HDLBP PCSK9 AP2A1 AP2A2 LIPA LIPC ZDHHC8 NPC1-1 CREB3L3 LIPG LDLRAP1 AP2M1 MYLIP CUBN AMN APOA2 UBA52 APOA4 LSR APOE APOA5 SOAT1 SOAT2 NPC2 ANGPTL8 ANGPTL3 ANGPTL4 CES3 ABCG1 CETP MTTP LCAT LPL LMF2 PRKACA-1 LMF1 SAR1B PRKACB-1 RPS27A AP2S1 UBB;UBC APOF A2M LDLR FGF21 GPIHBP1 ABCA1 APOC4 APOC3 MBTPS1 APOBR NR1H3 AP2B1 NCEH1 APOC2 ALB APOC1 CLTC P4HB CLTA NR1H2 MBTPS2 FURIN APOB PCSK6 PCSK5 VLDLR APOA1 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) GUSB NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration ACO1 IDH1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism HS3ST4 HS3ST1 HS3ST2 RPIA GALNS PFKL GALE PC GNPDA1 CHSY1-1 GNPDA2 PFKM PFKP B3GNT3 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 ABCC5 CTSV;CTSL PGK1 CALM3;CALM1 GAPDHS G6PC1 NUP205 NUP188 AAAS NUP42 SLC9A1 NUP62 TPR NUP88 RAE1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 IDUA HEXB NCAN HEXA BGN GLB1L3 DCN PCK1 GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB PRKACA-1 PRKACB-1 GCK SLC35B3 SLC35B2 NUP107 HPSE2 UXS1 XYLT2 XYLT1 ENO1 ENO2 ENO3 G6PD HS6ST1 PPP2R1B ENO4 PPP2R1A HS6ST2 HS6ST3 NDST2 NDST1 NDST4 NDST3 XYLB GALM-2 GLCE OMD TALDO1 PHKA1 HSPG2 PHKA2 PPP1R3C NHLRC1 HS3ST3A1 NUP160 SDC4 SDC2 SLC35D2 SDC3 GNS NUP85 CHST11 CHST12 CHST15 ST3GAL6 CHST13 CHST14 B4GALNT2 PCK2 DERA EXT1 EXT2 PPP2CB;PPP2CA B4GAT1 SDC1 FUT6;FUT5;FUT3 PYGB GBE1 STAB2 SEC13 AKR1B1 PYGM NUP133 PYGL KHK GYS2 PPP2R5D GYS1 B3GALT2 HYAL2 B3GALT1 MANBA CHST6 TPI1 CHST7 PGAM1 GAA PGAM2 AKR1A1 PGM2L1 B3GNT7 B3GNT4 FAM20B B3GNT2 NUP43 CHST1 ALDOC ALDOB TKT ALDOA SPAM1 CHST2 RANBP2 CD44 AGL-1 CHST3 PAPSS2 PAPSS1 EXTL2 GPC1 HAS1 SLC17A5 GPC3 GPI HAS3 HAS2 UBA52 GPC2 GPC5 GPC4 EXTL3 GPC6 GLYCTK LYVE1 NUP37 AGRN FMOD CHPF NAGLU CHP1 SLC26A11 GYG2 GYG1 EPM2A CSGALNACT1 CSGALNACT2 RPS27A KERA UBB;UBC PGD SHPK RPE;RPEL1 PFKFB2 PFKFB1 SLC26A2 CEMIP PFKFB4 SLC26A1 PFKFB3 HMMR FUT2 FUT1 FUT4 TKFC FUT7 FUT9 DSEL GCKR SLC37A1 B3GALT4 B3GALT6 PHKB B3GALT5 G6PC2 G6PC3 MAN2B2 UST OGN CRYL1 MAN2B1 HPSE GALK1 B4GALT2 B4GALT3 B4GALT1 ADPGK SLC2A1 HK2 SGSH HK1 HS2ST1 HK3 GAPDH-1 DSE PGM2 MAN2C1 PGLS SLC37A4 PGM1 HS3ST3B1 CHPF2 DCXR SORD BPGM HKDC1 ALDH1A1 PXYLP1 LALBA B4GALT6 B4GALT7 FBP1 RBKS B4GALT4 FBP2 B4GALT5 ST6GALNAC6 PRPS2 PRPS1 GALT PRELP ACAN UGP2 PHKG1 PHKG2 CHSY3 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 SRGAP2 RAC1 SRGAP1 ROBO1 CDC42 ARHGAP39 SRGAP3 SLIT2 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TLR4 LY96 RPS27A TBK1 UBB;UBC OPTN-1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE UBA52 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation ADH5 ALDH1A1 ADH4 ADH1C;ADH1B;ADH1A ACSS2 ALDH2 ALDH1B1 ACSS1 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants FLT3 FLT3LG UBA52 RPS27A UBB;UBC CBL DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 MBD3 RXRA SMAD1 SMAD4 PPARG GATAD2B GATAD2A PPARA HDAC2 RBBP4 PPARGC1B RBBP7 HDAC1 CHD4 CHD3 UCP1 HNRNPU MTA1 PRDM16 ZNF423 MTA3 ELOVL3 CIDEA EBF2 MTA2 BMP7 PPARGC1A NCOA1 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins PIAS3 SUMO3 UBE2I NFKBIA RELA NFKB2 IKBKE TOPORS PIAS4 IKBKG SUMO1 EIF2AK2 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage HPRT1 GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP-1 ADA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins PARP9 UBE2I PARP14 PARP8 PARP10 CANX ST6GALNAC2 PRKCSH SUMO1 GANAB ST3GAL4 MGAT1 UBA52 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 MOGS ST6GALNAC3 ST6GALNAC4 RPS27A UBB;UBC GSK3A PARP6 PARP4 GSK3B GALNT1 PARP16 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway GNB1 GNB4 GNB3 GNB5 PPP3CA PPP3CB PPP3R1 AGO3;AGO1 MAP3K7 NFATC1 CALM3;CALM1 TCF7 CTNNB1 CAMK2A ITPR1 GNGT1 ITPR2 ITPR3 WNT5A GNAT2 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 PLCB2 NLK PDE6B PDE6A GNAO1 LEF1 GNG10 WNT11 TCF7L2 TCF7L1 GNG2 TNRC6A-1 GNG5 GNG4 GNG8 TNRC6C TNRC6B FZD3 FZD2 FZD5 FZD4 MOV10 AGO4 AGO2 FZD6 GNG13 GNB2 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors UBE2I EGFR ESR1 KCTD1 NOP2 YEATS4 SUMO1 ATAD2 NPM1-2 KCTD15 TFAP2A MYC TFAP2C TGFA TFAP2D TFAP2E;TFAP2B KIT APOE KDM5B MYBL2 YY1 CDKN1A HSPD1 PITX2 ERBB2 EP300 CGA CITED1 DEK CITED2 CITED4 VEGFA WWOX CREBBP DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS MAOA ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs ALK NPM1-2 EML4 FN1 PPM1B HIP1 BCL11A PRKAR1A EIF2AK3 STRN BIRC6 CLTC PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism ALDH4A1 PRODH2 PRODH;LOC102724788 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination TERF2IP H2BC21 H2AZ2;H2AZ1 H2AJ TERF1-1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 NTHL1 TDG MBD4 H2BC1 SMUG1 NEIL3 NEIL2 NEIL1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 TERF2 POT1 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A NUP107 RPLP2 RPL36-1 HSP90AA1 PARP1 RPS3A DNAJC3-1 RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU NUP160 RPL26L1 NUP85 RPS27 SEC13 NUP133 NUP43 RANBP2 UBA52 NUP37 RPS27A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 NUP205 NUP188 AAAS NUP42 NUP62 TPR NUP88 RAE1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 RPL4 RPL30 RPL3 RPL32 RPL31 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) UBA52 CHMP4C CHMP4B CHMP3 CHMP4A TSG101 CHMP6 VPS4B CHMP7 VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D RPS27A VPS37A UBB;UBC SNF8 STAM VPS37B UBAP1 HGS VPS25 VPS28 STAM2 CHMP5 CHMP2B CHMP2A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known PCGF5 RNF2 HIPK2 SMARCB1 ARID2 RYBP SMARCC1 SMARCC2 CSNK2A1;CSNK2A3 SMARCD1 SMARCD2 AUTS2 CSNK2A2 CSNK2B CBFB YAF2 SMARCA2 SMARCD3 SMARCE1 SMARCA4 RUNX1 CBX8 CBX6 ARID1A PHC2 ARID1B PHC1 CBX4 CBX2 PBRM1 PHC3 EP300 ACTL6B BMI1 ACTL6A RING1 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 TUFM MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS36 MRPS33 MRPL18 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 LOC107987373;MRPL23 MRPL30 MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints PSMD8 PSMD6 PLK3 PSMD7 PSMD2 PSMD3 PSMD1 CDKN2A BTRC SKP1 ATM FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CDKN1A RPS27A CDKN1B UBB;UBC ADRM1 RBX1 PSMA2-1 TP53 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CCNE2 GSK3B CCNE1 CDK2 MAPK14 CSNK1A1 TPTEP2-CSNK1E;CSNK1E NEK11 MAPK11 CHEK1 MDM2-2 PHF20 CHEK2 ZNF385A COP1 PCBP4 MDM4 CCNA2-1 CCNA1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFB1 ARHGEF18 RPS27A CGN UBB;UBC F11R PRKCZ RHOA PARD6A FKBP1A PARD3 SMURF1 TGFBR1-1 TGFBR2 UBA52 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis POLR2E POLR2F NUP107 POLR2G POLR2H POLR2I POLR2L NUP43 GTF2F1 GTF2F2 RANBP2 POLR2J;POLR2J2;POLR2J3 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 POLR2A POLR2B POLR2C POLR2D CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling RELA HRAS LYN RAF1 PRKACA-1 PRKACB-1 NFKB1 EP300 PAK1 ICAM2 ICAM3 RELB PAK3 CLEC4M;CD209-2 PAK2 RPS6KA5 FYN CREBBP NRAS ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle GARRE1 ARHGEF26 SHMT2 PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 STX5 YKT6 PAK4 VAV1 NDUFA5 MCAM ARHGAP39 MCF2 MAP3K11 LBR ERBIN HSPE1 MPP7 LAMTOR1 DOCK3 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 PAK2 TFRC CAV1 DSG2 VAV3 VAV2 CDC42 ITGB1 CYFIP1 DOCK5 DOCK4 ANKLE2 TRIO ITSN1 ARHGAP1 ARHGDIG PIK3R1 ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L STBD1 ARHGDIB EMD PGRMC2 TMPO PLEKHG3 ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 EPHA2 VAMP3 RAB7A TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism PPP1CC MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 PRKACA-1 CAV1 FABP6 PRKACB-1 FABP7 GPD2 PLIN3 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 LPIN3 MGLL GPAM ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors EP300 TFAP2A TFAP2C TFAP2D CITED1 CITED2 TFAP2E;TFAP2B CITED4 WWOX CREBBP YEATS4 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose HK1 GMPPB PMM1 MPI GMPPA PMM2 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PPP2R2A;PPP2R2D IKBKB PPP2R1B PPP2R1A GNAQ IKBKG VCL CHUK YAP1-1 IKBKE STAT1 ITGB1 RELA CAPNS1 CAPNS2 CAPN2 PPP2CB;PPP2CA ABL1 ITGA5 NFKB1 NFKBIA ITGB3 PTPN1 GNA11 PIEZO1 ITGAV ANXA2 PTK2 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 ABCA3 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA RPS27A UBB;UBC CBL GAB1 SOS1 SHC1-1 PLCG1 EGF UBA52 NRAS SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors RPL34 RPL10A RAC1 RPL8 RPL9 RPL6 RPL7 RPS15 COL4A5 RPS14 RPS17 RPS16 PAK4 RPL18A RPS19 ARHGAP39 RPS18 RPL37A-1 SRGAP3 SLIT2 RPL35 SRGAP2 RPL38 SRGAP1 ROBO1 PAK1 RPS11 RPL39 RPS10 PAK3 RPL15-1 PAK2 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 PRKACA-1 SRC PRKACB-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A BUB1B-PAK6;PAK6 MSI1 RPLP2 DAG1 RPL36-1 HOXA2 ISL1 PRKCA PFN1 RPS3A CUL2 GSPT2 GSPT1 RPL13A-1 FLRT3 RPL11 PRKAR2A RPS27L ABL2 RPS15A VASP RPL14 PABPC1;PABPC3 RPS3 CXCL12 RPL13 LHX3 RPL12-1 LHX2 RPS2 LHX4 RPL18 LHX9 SOS1 CDC42 RPL17 ROBO2 RPL19 NRP1 RPL35A USP33 RPL23A NCK2 NCK1 RPL22L1 UPF2 FAU CAP1 DCC RPL26L1 ENAH ETF1 LDB1 EVL PFN2-1 SOS2 CXCR4 AKAP5 NTN1 ZSWIM8 SLIT1 SLIT3 PAK5 RPS27 CAP2 MYO9B NELL2 ELOC-1 ELOB NCBP1 EIF4A3 CASC3 NCBP2-1 PSMD8 PSMD6 PSMD7 PPP3CB PSMD2 CLASP1 PSMD3 CLASP2 PSMD1 RBM8A EIF4G1 PSMC2-1 GPC1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 MAGOH;MAGOHB PSMD12 PSMD11 PSMD14 PSMD13 UPF3B RNPS1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RHOA ABL1 RPL4 RPL30 RPL3 RPL32 RPL31 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis NPL NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 CTSA SLC35A1 ST6GALNAC2 NUS1 ST8SIA1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK SLC17A5 FCSK DOLPP1 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 GLB1 ST6GALNAC3 MVD ST6GALNAC4 GMPPB PMM1 MPI GMPPA PMM2 HK1 ST3GAL6 ST6GALNAC1 CMAS NANP FPGT PGM3 ST6GALNAC6 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry VCP-1 AGRN CTSV;CTSL SDC1 FURIN GPC1 NRP1 HSPG2 GPC3 TMPRSS2 ACE2 GPC2 SDC4 GPC5 SDC2 GPC4 SDC3 GPC6 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling HBEGF MAPK1 MAPK3 EGFR FOS CDKN1B XPO1 SRF CCND1 AKT2 TGFA AKT3 AKT1 EGF FOXO3 ELK1 BCL2 UHMK1 AREG EREG BTC PTK2 EPGN NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival NFKB1 NGFR IRAK1 SQSTM1 NFKBIA RELA IKBKB TRAF6 NGF UBA52 RPS27A UBB;UBC CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis PNMT DDC TH DBH CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis VCAN CHPF2 CHST11 CHST12 CHST15 CHPF CHST13 CSPG5 CSPG4 CHSY1-1 UST CSGALNACT1 CSGALNACT2 CHST3 NCAN CHSY3 BGN DCN CHST7 BCAN LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis APP AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 VAMP2 GNS ARF1 CTSZ CLTB AP4E1 AP4M1 AP1G2 BLOC1S1 CLVS2 AP4S1 CLVS1 TXNDC5 HGS HSPA8 M6PR AP4B1 DNM2 VAMP8 CHMP2A SH3GL2 VAMP7 DNAJC6 DNASE2 ARRB1 CLTC CLTA METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation MAT1A MAT2B COMT TRMT112 AS3MT MAT2A N6AMT1 CYP1A2 MTRR TPMT AHCY NNMT GSTO1 MTR-1 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins CDK9 CCNT1 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling FLT3 PIK3CB HRAS PDPK1 FRS2 KLB IRS1 PDE3B PIK3CA PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 GAB1 FGF9 SOS1 AKT2 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 FGF10 PTPN11 FLT3LG PIK3R2 PIK3R1 THEM4 NRAS DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS ABCC2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions ITGB4 ITGA3 ITGA2 COL18A1 ITGA1 NID1 NID2 ITGA7 ITGA6 LAMA5 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 ITGB1 ITGAV TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis CEBPB H2BC21 H2AZ2;H2AZ1 H2AJ RXRA LEF1 GATA2 RARA H2AC14 MYC H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 STAT3 H2BC1 CBFB RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 CEBPA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 CSF3R CEBPE GFI1 CDKN1A KMT2A IL6R FLI1 KLF5 TAL1 EP300 H2AC20 E2F1 MYB H2AB2;H2AB3;H2AB1 DEK TFDP1 TFDP2 SPI1 CDK4 CDK2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation HERC6 TRAIP-1 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 ANAPC7 RNF34 DET1 UBE2C LRSAM1 SH3RF1 UBE2E1 TRIM9 UBE2D1 ANAPC10 ARIH2 ANAPC11 LRRC41 MIB2 RNF144B CDC23 GAN RNF130 UBE2S CDC26 GPR75-ASB3;ASB3-1 CDC16 HUWE1 CDC27 KLHL2 KLHL3 UBE2G1 ANAPC4 UBE2G2 ANAPC5 KLHL9 ANAPC1 SPSB2 ANAPC2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 FBXO15 UBE2E2 UBE4A LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 SMURF2 KLHL13 SMURF1 UBR1 FBXO44 FBXO41 FBXO40 RBBP6 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 ELOC-1 UBA3 RNF182 ELOB UBE2O TPP2 UBA1 BLMH UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 RNF138-1 THOP1 RNF213-2 MGRN1 ASB13 ASB14 RNF6 ASB11 RNF7 ASB12 ASB17 RNF4 RCHY1 ASB18 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 ASB10 HECTD3 VHL FBXO4 TRIM41 RNF25 FBXO6 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXW4 FBXL16 FBXL13 FBXL14 FBXW10;CDRT1 FBXL12 FBXW5 TRIM39 ASB8 ASB9 FBXW7 ASB6 LNX1 FBXW9 TRIM36 FBXW2 ASB7 ASB4 TRIM37 ASB5 ASB2 TRIM32 ASB1 RBX1 SOCS3 FBXO32 FBXL3 FBXL5 TRIM63 PRKN ITCH STUB1 CUL3 KBTBD7 MYLIP UBE2B FZR1 SKP2 CDC20 CUL2 RNF111 NEDD4L PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 UBE2D3-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 WWP1 LRR1 CCNF KEAP1 CBLB UBE2L6 DCAF1 HERC5 HERC4 CDC34 HERC3 RNF115 RNF114 UBE2V1 HERC2 HERC1 FBXO7 UBE2D3;UBE2D2 TRIM21 UBE2N FBXO9 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT5 CCT4 NOP56 ARFGEF2 CCT6A SKIV2L FBXL3 FBXL5 DCAF7 CCT6B WRAP53 KIF13A FBXO4 LONP2 FBXO6 STAT3 FBXW4 CCT3 CCT2 FBXW10;CDRT1 HDAC3 FBXW5 FBXW7 SPHK1 FBXW9 FBXW2 XRN2 TCP1 GAPDHS FKBP9 TP53 GBA AP3M1 CCNE2 CCT8 CCNE1 CCT7 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC FBXL3 SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 PER2 SEM1 PER1 CRY2 PSMC5 CRY1 PSMC6 PSMC3 PSMC4 PSMC1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors CHRND CHRNG CHRNE CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling ITGA3 ITGA2 HGF LAMA5 LAMB3 LAMA2 LAMB2 SRC LAMA1 LAMC3 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 MET ITGB1 PTK2 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction TJP1 GJA1 PATJ MPP5 CRB3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation FGFBP1 FGFBP3 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency GSS SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants CTBP2 CTBP1 TCF7L2 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle GARRE1 ARHGAP21 LMAN1 YKT6 PAK4 MCAM ARHGAP39 MCF2 LBR ERBIN SRGAP2 MPP7 LAMTOR1 PAK1 VANGL1 ARHGAP32 DIAPH3 TIAM1 ESYT1 PAK2 TFRC JAG1 CAV1 DSG2 VAV2 NCKAP1 WASF1-1 ABL2 NCF1 NCF2 SNAP23 NCF4 ARHGAP6 DOCK10 RAPGEF1 SYDE1 CDC42 ARHGAP42 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 ARAP3 CYBB ITGB1 OCRL CYFIP1 CYBA BCR AMIGO2 NOXO1 TRIO ARHGAP17 ARHGAP15 ARHGAP1 PIK3R2 ABR PIK3R1 RACGAP1 ARHGAP5 SLITRK3 ARHGAP35 NHS PREX1 SLITRK5 OPHN1 NCKAP1L WASF2 GIT2 STBD1 BAIAP2 ARHGDIB ARHGAP26 EMD PGRMC2 ABI2 TMPO TAOK3 ABI1 NOXA1 NOX3 VRK2 SLC1A5 NOX1 LEMD3 FERMT2 DEPDC1B CDC42EP1 EPHA2 VAMP3 RAB7A RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration CBFB ITGA4 SPP1 RUNX3 ITGAL DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death H2AJ CDKN2A YWHAE CAST APP JUN FASLG CDC25C SUZ12 SOD2 FOXO3 H2BC5 CDC25A LMNB1 CDC25B GOLGA2 H2BC1 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 H2AC4 MLKL TP53 H2BC21 EED H2AZ2;H2AZ1 TRADD CASP8 H2AC14 RBBP4 RIPK3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TRAF2 RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RIPK1 FADD H2AC20 C1QBP H2AB2;H2AB3;H2AB1 DNMT3B EZH2 DNMT3A PRIM2 DNMT1 PRIM1 GSDME POLA1 POLA2 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption SLC2A2 SLC2A5 GUCY2C PNLIPRP1 MGAM TREH GUCA2B CEL ALPG;ALPP;ALPI-1 GUCA2A LIPF CHIT1 CLPS SI PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B LCT PNLIP RSC1A1 SLC5A1-1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H POLR2I POLR2L GTF2H1 TAF8 GTF2F1 TAF4B GTF2H3 TAF7 GTF2F2 TAF6 GTF2H4 TAF5 CDK7 TAF4 POLR2J;POLR2J2;POLR2J3 TAF3 ERCC3 TAF2 ERCC2 TAF1 MNAT1 GTF2B TAF7L TBP GTF2A1 GTF2A2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH TAF9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C TAF15 POLR2D TAF12 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling EGFR PLCG1 EGF ERBB2 NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 YWHAE CAST APP JUN FASLG CDC25C SOD2 FOXO3 CDC25A LMNB1 CDC25B GOLGA2 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer NCOR1 PSENEN TBL1XR1 PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SKP1 HDAC5 HDAC2 UBA52 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 MIB2 CUL1 SNW1 JAG2 JAG1 ADAM10 HDAC10 DLL1 HDAC11 MIB1 DLL4 NEURL1B ADAM17 NCOR2 RPS27A NEURL1 KAT2B UBB;UBC KAT2A NOTCH1 RBX1 RBPJ HDAC4 MAMLD1 CCNC-1 MYC HDAC3 HEY1 MAML2 HEY2 HES1 MAML1 EP300 CDK8 CREBBP DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis PPIA THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis RAC1 HCK LCK CD8B;CD8B2 ELMO1 AP2A1 AP2A2 AP1G1 AP2M1 PACS1 AP1S2 PAK2 AP1B1 AP1S1 FYN AP1S3 B2M AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD4 ARF1 AP2S1 CD28 AP2B1 DOCK2 ATP6V1H CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis DHCR7 LBR IDI2 MSMO1 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 PLPP6 TM7SF2 HMGCS1-1 GGPS1 LSS SREBF2 MVD IDI1 MVK SREBF1 PMVK SC5D FDFT1 FDPS CYP51A1 SQLE DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW3;OPN1MW2;OPN1MW;OPN1LW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation UPK1A EPCAM TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 CNOT2 CNOT3 RBBP8 ATRIP BARD1 CNOT8 CNOT9 RPA1 RPA2 FOS YWHAH RAD50 RPA3 CSNK2A1;CSNK2A3 AGO3;AGO1 RAD17 ATM RAD1 RAD9B RAD9A ATR RICTOR HDAC2 YWHAZ RNF34 GLS2 NLRC4 HDAC1 CCNB1 RFFL TXNRD1 CDK1 PML TP53RK NUAK1 TP53BP2 BANP GADD45A TPX2 PLK2 MDC1 PRMT1 YWHAB PRR5 NOC2L COX7A2L-1 STEAP3 MLST8 YWHAG PDPK1 SCO2 MAPK14 DDIT4 FANCD2 MEAF6 MAPK11 COX7A2 PRKAA1 NPM1-2 PRKAA2 PMAIP1 SFN RBBP4 PRELID3A TP53I3 RBBP7 JMY ATF2 TNRC6A-1 MTOR CASP6 TNRC6C CASP2 TNRC6B CCNK BBC3 CCNT1 RBL2 ELL RBL1 ELOC-1 TAF7L CASP10 ELOA ELOB NELFB NELFA NELFCD EP300 NELFE SUPT16H CNOT6L TBP ARID3A CTDP1 DDB2 TAF9 RPTOR CREBBP STK11 SUPT4H1-1 TAF15 TAF12 TSC2 TAF13 TSC1 TAF10 TAF11 RRAGA SSRP1 RRAGC CDK9 CARM1 RRAGB RRAGD CCNT2-1 TAF8 PLAGL1 TCEA1 TAF4B TAF7 BID SLC38A9 TAF6 TAF5 MBD3 TAF4 RHEB TAF3 LAMTOR2 TAF2 LAMTOR1 TAF1 LAMTOR4 LAMTOR3 LAMTOR5 GATAD2B YWHAE GATAD2A JUN CENPJ CDC25C PRDX2 CDK5 PRDX1 SESN3 SESN2 CDK5R1 KMT5A BNIP3L TP53 BCL2L14 ZNF420 BRPF1 RGCC CASP1 TP63 PIN1 PPP1R13B COX4I1 COX4I2 PTEN PPP1R13L TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A APAF1 CYCS-1 RABGGTB RABGGTA RRM2B TP53INP1 FAS E2F7 E2F8 BAX NDUFA4 L3MBTL1 CRADD TP73 COX7B COX7C COX8A CDKN1A CDKN1B COX8C BRPF3-1 COX5B E2F1 COX5A DAXX PERP COX6C TFDP1 TFDP2 TTC5 CCNE2 CCNG1 CCNE1 CDK2 PRDM1 COX6A1 COX6A2 G6PD PPP2R1B PPP2R1A COX6B2 COX6B1 SMYD2-1 NDRG1 EHMT2 EHMT1 CNOT10 MAPKAPK5 CNOT11 DYRK2 MDM2-2 CHD4 TXN CHD3 PIDD1 YWHAQ MAP2K6 TMEM219 AURKA PPP2CB;PPP2CA MTA2 GLS SGK1-1 MDM4 PIP4K2A PPP2R5C PIP4K2B CCNA2-1 BIRC5 CCNA1 E2F4-1 AURKB PLK3 PRELID1 CDKN2A CDK12 CDK13 GPI BTG2 UBA52 SETD9 CHM ING5 ING2 MSH2 PIP4P1 AIFM2 PMS2 MLH1 TNKS1BP1 BRD1 RPS27A UBB;UBC PRMT5 BRD7 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A TIGAR POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G HIPK1 POLR2H POU4F1 POLR2I POU4F2 POLR2L HIPK2 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 AKT2 AKT3 MRE11 AKT1 BRCA1 USP7 PRKAB2 KAT5 CSNK2A2 IGFBP3 PRKAB1 USP2 CSNK2B EXO1 CHEK1 KAT6A NBN TOPBP1 MAPKAP1 PHF20 CHEK2 RFC5 RMI2 ZNF385A RFC3 PCBP4 RFC4 RMI1 RFC2 TOP3A HUS1 RAD51D MOV10 DNA2 AGO4 RHNO1 AGO2 BLM FANCI PCNA PRKAG1 FANCC PRKAG2 CNOT4 WRN CNOT6 BRIP1 CNOT7 BCL6 PRKAG3 CNOT1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB APEX1 XRCC1 LIG3 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RPA3 CSNK2A1;CSNK2A3 RAD17 ATM RAD1 RAD9B L3MBTL1 RAD9A ATR HDAC2 RICTOR RNF34 HDAC1 RFFL CDK1 TP73 PML TP53RK BRPF3-1 NUAK1 TP53BP2 BANP TPX2 DAXX TTC5 PRR5 NOC2L CCNG1 CDK2 PRDM1 MLST8 PDPK1 PPP2R1B MAPK14 PPP2R1A MEAF6 MAPK11 SMYD2-1 PRKAA1 PRKAA2 EHMT2 EHMT1 RBBP4 RBBP7 MAPKAPK5 JMY DYRK2 MDM2-2 CHD4 CHD3 MTOR MAP2K6 AURKA PPP2CB;PPP2CA MTA2 TAF7L EP300 SGK1-1 SUPT16H MDM4 TBP PIP4K2A PPP2R5C PIP4K2B CCNA2-1 TAF9 STK11 CCNA1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 AURKB TAF8 PLK3 TAF4B TAF7 TAF6 TAF5 MBD3 CDKN2A TAF4 TAF3 TAF2 TAF1 GATAD2B GATAD2A UBA52 SETD9 CDK5 ING5 ING2 PIP4P1 CDK5R1 KMT5A BRD1 RPS27A UBB;UBC TP53 PRMT5 BRD7 HIPK1 POU4F1 POU4F2 HIPK2 BRPF1 AKT2 TP63 PIN1 MRE11 AKT3 AKT1 USP7 BRCA1 PRKAB2 PPP1R13B KAT5 CSNK2A2 USP2 PRKAB1 CSNK2B EXO1 CHEK1 KAT6A PPP1R13L NBN TOPBP1 MAPKAP1 PHF20 CHEK2 RFC5 ZNF385A RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 DNA2 RHNO1 TP53INP1 BLM PRKAG1 PRKAG2 WRN BRIP1 PRKAG3 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection GNB1 GNB4 RAC1 GNB3 GNB5 VAV1 HCK ELMO1 CYFIP2 WIPF1 WIPF2 WIPF3 PYCARD AHCYL1 CYSLTR1 CYSLTR2 GNAT3 C3AR1 GGT1 ENTPD1 ENTPD5 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 BTK DPEP2 DPEP1 GNAZ MEFV NCKIPSD FCGR3A;FCGR3B PRKAR2B NFKB2 IL10 DVL1 CD163 PLCG2 PLK2 DVL2 RHBDF2 DVL3 VAV3 MYH9 NLRP3 ITPR1 GGT5 ITPR2 MYO5A ARPC4 ARPC5 ITPR3 PTK2 ARPC2 ARPC3 ACTR3-1 MAPK1 ARPC1B VAV2 ARPC1A WASL MAPK3 PSTPIP1 CTSG ACTR2 SYK FGR MAPK14 ADORA2B ADCY4 TXNIP PRKAR2A GNAI3 WAS HSP90AB1 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 CDC42 PRKAR1A CRK ADCY6 ACTG1 GNAI2 ADCY5 NT5E NCK1 FCGR1A FYN WASF3 MYO10 P2RX7 P2RX4 MYO1C SUGT1 TXN MYO9B HMOX1 IL6 FURIN MAPK8 CALM3;CALM1 JUN PLCG1 RELA ADAM17 NFKB1 GNGT1 WNT5A C3-1 GNAS-1 ACTB-1 NCKAP1 WASF1-1 CASP1 IL18 IL1A GNG10 IL1B CYFIP1 CYBA GNG2 GNG5 NOXO1 GNG4 GNG8 NCKAP1L LYN WASF2 ABL1 BAIAP2 YES1 ABI2 ABI1 NOXA1 GSDMD NOX1 FZD7 ELMO2 CD3G DOCK1 GNG13 GNB2 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CSNK2A1;CSNK2A3 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NEDD4 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 AKT2 AKT3 AKT1 CSNK2A2 PTEN CSNK2B PREX2 TRIM27 USP13 TNKS TNKS2 WWP2 RNF146 FRK OTUD3 XIAP MKRN1 STUB1 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells KCNMB1 KCNMA1 CHRNA10 KCNN2 CHRNA9 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) POLD2 MSH6 MSH2 RPA1 PMS2 RPA2 MLH1 LIG1 RPA3 PCNA POLD3 POLD4 EXO1 POLD1 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism NPL NEU2 NEU3 NEU4 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 CTSA SLC35A1 ST6GALNAC2 ST8SIA1 ST8SIA2 ST8SIA3 SLC17A5 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 GLB1 ST3GAL6 ST6GALNAC3 ST6GALNAC4 ST6GALNAC1 CMAS NANP ST6GALNAC6 NANS ST6GAL2 ST6GALNAC5 GNE STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling EP300 PRDM1 HDAC3 HDAC2 HIF1A DNMT1 CD274 SIN3A STAT3 HDAC1 IL2RG SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol PLCD1 PLCB3 PLCB1 PLCB2 CALM3;CALM1 PLCG1 PTEN OCRL INPPL1 PLD4 INPP5B PLCZ1 INPP5D INPP5J PLCE1 ITPK1 PLCG2 ITPKB ITPKC PLCB4 SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism PM20D1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation ITGB3BP PAFAH1B1 DYNC1I2 NEK9 CENPA NEK6 AURKB NEK7 NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM PLK1 B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 ERCC6L NUP107 ZWILCH BUB1B PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 EML4 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization CATSPER1 CATSPER3 CATSPER2 CATSPER4 HVCN1 ADAM21 ADAM20 ZP3;POMZP3 IZUMO3 SPAM1 OVGP1 IZUMO2 IZUMO4 B4GALT1 ADAM30 ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG CD9 ZP1 IZUMO1-1 ZP2 ZP4 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission GNB1 GNB4 RAC1 GNB3 GNB5 RPS6KA1 AP2A1 KPNA2 GNAT3 ACTN2 GRIN2C ADCY9 PRKACA-1 SRC PPM1E PRKAR1B PPM1F PRKACB-1 GRIN1 GRIN2D GRIN2A DLG2 CAMK4 NEFL CAMK1 PRKAR2B CAMK2B CAMK2D CAMK2A NRAS MAPK1 HRAS CAMK2G MAPK3 PRKCA PDPK1 PLCB3 PLCB1 PLCB2 ADCY4 PRKAR2A GNAI3 ADCY3 PRKAA1 PRKX PRKAA2 ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 PRKAR1A ADCY6 RPS6KA3 GNAI2 RPS6KA2 ADCY5 MYO6 MDM2-2 AKAP5 CALM3;CALM1 PRKCB GRIN2B GRIP1 RPS6KA6 NSF PRKCG CASK GRIP2 GRIA1 LIN7A LIN7C LIN7B EPB41L1 TSPAN7 GRIA3 GRIA4 GRIN3B GNAL GRIN3A NBEA GABRB3 GABRB2 GABRB1 RASGRF2 RASGRF1 KIF17 CHRNB2 NRGN CHRNA1 GABRR3 CHRNB4 GABRR2 CHRNA3 GABRR1 CHRNB3 GABRG3;GABRG2 GRIA2 CHRNA5 NPTN CHRNA4 NRG1 CHRNA6 GNGT1 HTR3A CHRNA9 HTR3B PICK1 CHRNA7;CHRFAM7A CHRNA2-1 CAMKK1 CAMKK2 CHRND GLRA1 CHRNG CACNG8 CHRNE GLRA2 GLRA3 CACNG2 DLG1 CACNG3 DLG3 KCNJ2 DLG4 CACNG4 GRIK5 KCNJ3 GRIK3 KCNJ12;KCNJ18 GRIK4 KCNJ4 GRIK1 GABRA2 GRIK2 GABRQ NCALD GABRA1 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 GABRA6 GABRA5 KCNJ9 GABRA4 GIT1 GABRA3 PRKAB2 KCNJ15 KCNJ16 PRKAB1 GLRB GNG10 APBA1 GNG2 GNG5 GNG4 GNG8 PRKAG1 PRKAG2 GNG13 GNB2 PRKAG3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development SLC2A2 MAMLD1 IAPP AKT2 AKT3 AKT1 ONECUT1 NEUROD1 NKX6-1 FGF10 NKX2-2 PDX1 PAX6 HNF1B SNW1 HNF1A MAFA RFX6 INSM1 HNF4G PTF1A FOXA3 NEUROG3 FOXA2 KAT2B KAT2A NOTCH1 MAML2 HES1 FOXO1-1 MAML1 EP300 INS;INS-IGF2 GCK CREBBP RBPJ P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes NGFR IRAK1 SQSTM1 IKBKB TRAF6 NGF UBA52 PRKCI RIPK2 RPS27A MYD88 UBB;UBC ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade GNB1 SAG CNGA1 RHO GNAT1 CNGB1 GNGT1 PDE6B PDE6A SLC24A1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane DUSP6 TAB2 DUSP7 TAB1 TLR10 TLR5 LRRC14 MAPK9 USP14 MAPK8 NLRX1 MAPK7 RPS6KA1 PELI3 IKBKB PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 IKBKG S100A12 MAPK10 BTRC N4BP1 MAP3K7 MAP3K1 SKP1 TNIP2 CHUK USP18;USP41 FBXW11 APP JUN ELK1 UBA52 CUL1 RELA MAP3K8 RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKB2 TIFA ALPK1 NFKBIB MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 CASP8 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 RPS6KA5 MAP2K3 MAP2K4 TRAF2 ATF2 PELI1 MAP2K7 MAP2K6 PPP2CB;PPP2CA HMGB1-1 RIPK2 MYD88 ATF1 ECSIT PPP2R5D SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 IKBIP UBE2V1 DUSP4 MEF2C MEF2A DUSP3 IRAK4 UBE2N VRK3 TAB3 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SMARCD3 NCOR1 RORC TBL1XR1 HDAC3 CARM1 CHD9 RORA HELZ2 SREBF1 RXRA TGS1 NRIP1 EP300 CPT1A PPARA PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 NR1D1 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT KIT DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2BC21 EED H2AZ2;H2AZ1 H2AJ H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SUZ12 H2BC5 RBBP7 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 DNMT3B EZH2 DNMT3A PRIM2 DNMT1 PRIM1 GSDME POLA1 POLA2 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions JAK2 FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ATG7 VCL CALM3;CALM1 PAPSS1 TENT4A AKAP9-1 KIAA1549 MPRIP TRIM24 FXR1-1 AGTRAP AP3B1 SND1 ESRP1 KDM7A FAM114A2 ZC3HAV1 TRAK1 BCL2L11 LMNA MARK3 AGK QKI CLCN6 FAM131B AGGF1 SRC CAMK2B CAMK2D CAMK2A YWHAB NRAS RAP1A MAP2K2;MAP2K1 MAPK1 HRAS CAMK2G MAPK3 BRAF ITGA2B FN1 CSK ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium AKAP9-1 PLK1 HDAC6 CDK1 DYNC2I2 NEK2 DYNC2I1 TRAF3IP1 IFT172 CCP110 PRKACA-1 ARF4-1 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CSNK1D IFT80 PRKAR2B CYS1 RPGRIP1L LZTFL1 IFT88 IFT81 TTC30A;TTC30B UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B HSP90AA1 NPHP1 YWHAG CEP70 NPHP3 CEP72 PPP2R1A CEP192 KIF3C MARK4 RAB11FIP3 CEP76 CEP78 BBS2 PLK4 BBS1 ODF2 RAB3IP IFT122 BBIP1 IFT20 AHI1 IFT22 MKS1 CEP83 IFT27 DYNLRB2 DYNLRB1 CEP89 CEP57 TTC26 C2CD3 CETN2 CEP164 PKD2 PKD1 HSPB11 IFT52 ACTR1A TCTN3 TCTN2 MAPRE1-1 CNTRL TCTN1 BBS9 CNGA2 BBS7 CNGA4 IFT57 TNPO1 BBS5 CC2D2A CEP290 BBS4 RAB8A DYNLT5 IQCB1 CKAP5 MKKS EXOC8 DYNLT2 IFT140 EXOC7 HAUS4 KIF24 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 CLASP1 BBS12 RP2 TMEM216 EXOC4 DYNC1H1 EXOC3 EXOC6 NDE1 CEP63 EXOC5 YWHAE IFT46 EXOC2 EXOC1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 DYNLT2B B9D2 ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT CCT3 OFD1-1 CCT2 SEPTIN2 CEP152 GBF1 WDR19 SCLT1 RAB11A ATAT1 NEDD1 TTC8 TUBA4A ALMS1 CEP162 TCP1 TRIP11 B9D1 CEP41 CLUAP1 CEP43 KIF17 CCT8 CCT5 CCT4 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 SMO TPTEP2-CSNK1E;CSNK1E ARL13B INPP5E PDE6D RHO CNGB1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR2E POLR3E POLR2F POLR1C POLR3F POLR2H POLR1D POLR3G POLR2L POLR3H BDP1 POLR3K GTF3C1 GTF3C2 GTF3C3 CRCP TBP GTF3C4 GTF3C5 BRF1 POLR3GL GTF3A GTF3C6-1 POLR3A POLR3B POLR3C POLR3D RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation CBFB GLI2 IHH HDAC4 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network NAPA USP6NL NAPB SCOC TMF1 SYS1 STX16 ARL1 RHOBTB3 GCC2 GCC1 RABEPK NAPG STX10 TGOLN2 ARFRP1 GOLGA4 VPS51 VPS53 VPS52 GOLGA1 VTI1A STX6 VPS54 NSF ARFIP2 RAB6A RAB6B NAA30 COG8 COG7 RIC1 COG6 COG5 COG4 COG3 COG2 COG1 IGF2R RGP1 NAA35 PLIN3 RAB9A NAA38 VAMP4 M6PR RAB9B VAMP3 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins NUDT16 NUDT5 ADPRM NUDT15 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H POLR2I POLR2L GTF2H1 TAF8 GTF2F1 TAF4B GTF2H3 TAF7 GTF2F2 TAF6 GTF2H4 TAF5 CDK7 TAF4 POLR2J;POLR2J2;POLR2J3 TAF3 ERCC3 TAF2 ERCC2 TAF1 MNAT1 GTF2B TAF7L TBP GTF2A1 GTF2A2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH TAF9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C TAF15 POLR2D TAF12 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol C9orf64 TRDMT1 PUS3 TRMT112 TRMT10A TYW5 METTL1 NSUN2 TYW3 TPRKB ADAT1 CDKAL1 TRMT1 NSUN6 PUS7 FTSJ1 TRIT1 ADAT3 ADAT2 DUS2 QTRT1 TRMT9B QTRT2 CTU2 CTU1 TYW1;TYW1B TRMT5 TRMT6 TRMT12 TRMT13 TRMT11 TRMT61A TP53RK EPRS1 URM1 WDR4 THADA LAGE3 OSGEP THG1L ALKBH8 LCMT2 TRMT44 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling GP1BB FLNA GP5 VWF PIK3R1 YWHAZ RAF1 GP1BA GP9 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease DDX6 LSM1 LSM5 LSM4 PATL1 LSM3 LSM2 EDC3 EDC4 LSM7 LSM6 XRN1 DCP2-1 DCP1A DCP1B CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane SSTR3 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 ASAP1 HDAC6 CCT3 CCT2 GBF1 RAB11A ATAT1 TTC8 ARF4-1 TCP1 CYS1 LZTFL1 UNC119B ARL6 CCT8 ARL3 MCHR1 CCT5 CCT4 NPHP3 SMO RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 ARL13B INPP5E PDE6D PKD2 PKD1 BBS9 CNGA2 BBS7 CNGA4 RHO BBS5 CNGB1 BBS4 RAB8A MKKS EXOC8 EXOC7 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMD8 CDC20 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 FBXO5 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants FLT3 PTPN11 STAT5A STAT5B PIM1 NOX4 GRB2 GAB2 CDKN1A BCL2L1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9;CYP2C19 CYP2U1 CYP1B1 CYP1A2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP1A1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression FOS H2AJ AGO3;AGO1 KPNA2 TGFA H2BC5 HDAC1 H2BC1 FOSB H2AC4 CCND1 CITED1 FOXA1 KDM1A PRMT1 TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 H2BC21 CTSD NCOA3 SMC3 HSP90AA1 NR5A2 TFF1 KANK1 PTGES3-1 H2AZ2;H2AZ1 CXXC5 TFF3-1 KCTD6 KDM4B USF2 USF1 HSP90AB1 ZNF217 GATA3 EBAG9 CXCL12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ATF2 TNRC6A-1 CBFB RAD21 TNRC6C RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 STAG1 TNRC6B STAG2 CCNT1 NRIP1 EP300 MYB TBP GTF2A1 NCOA1 GTF2A2 MED1 SMC1A NCOA2 CREBBP CDK9 CARM1 JUN BCL2 YY1 KAT2B POLR2A POLR2B POLR2C POLR2D GPAM SP1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L ESR1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 H2AC14 PGR MYC KAT5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUND MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions NFASC RAC1 ITGA10 CNTN1 CNTN2 CD24 SCN2A SCN2B RPS6KA1 EGFR CSNK2A1;CSNK2A3 AP2A1 AP2A2 PAK1 AP2M1 NCAN RPS6KA6 AP2S1 HSPA8 DNM2 SH3GL2 AP2B1 ITGAV CLTC CLTA MAP2K2;MAP2K1 MAPK1 VAV2 MAPK3 DLG1 DLG3 DLG4 ITGA2B LAMA1 NRP2 CNTNAP1 RPS6KA4 LAMB1 ALCAM LAMC1 SCN11A CHL1 NRP1 RPS6KA3 DPYSL2 RPS6KA2 SCN9A NRCAM RPS6KA5 SCN5A EPHB2 CSNK2A2 SPTAN1 SCN1B CSNK2B ITGB1 SCN1A KIF4B;KIF4A LYPLA2 ANK2 ANK3 ANK1 ITGA2 SPTB ITGA1 DNM1 DNM3 SHTN1 GAP43 SCN10A SCN8A KCNQ2 NUMB SDCBP DCX KCNQ3 SCN4A ITGA5 EZR SCN4B ITGA9 SPTBN4 SPTBN5 SPTA1 SCN7A NCAM1 SCN3B ITGB3 SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN RANBP9 L1CAM SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SNRPG-2 SNRPD3 ZNF473 NCBP2-1 NCBP1 LSM10 SLBP LSM11 SNRPF SNRPB SNRPE-2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation MAMLD1 H2BC21 H2AZ2;H2AZ1 SIRT6 ELF3 H2AJ AGO3;AGO1 H2AC14 JUN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TNRC6A-1 H2BC1 TNRC6C NOTCH2 RUNX1 SNW1 H2BC15;H2BC3;H2BC11;H2BC12 NOTCH3 TNRC6B NOTCH4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 PRKCI KAT2B KAT2A NOTCH1 MAML2 MOV10 MAML1 ELANE AGO4 CCND1 EP300 H2AC20 TP53 E2F1 AGO2 E2F3 H2AB2;H2AB3;H2AB1 TFDP1 TFDP2 CREBBP RBPJ DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 PTPN11 HRAS PIK3R1 FRS2 PIK3CA FLRT3 FLRT2 FLRT1 FGF1 FGF2 FGF3 FGF4 FGF6 GAB1 FGF9 SOS1 FRS3 FGF20 FGF23 FGF22 PLCG1 NRAS FGF10 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants FLT3 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA ACADL HADHA HADHB-1 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation MEAF6 MBD3 BRPF1 GATAD2B AKT2 GATAD2A PIN1 HDAC2 RBBP4 AKT3 AKT1 RBBP7 HDAC1 KAT6A CHD4 CHD3 ING5 ING2 PIP4P1 MAP2K6 PML MTA2 BRD1 BRPF3-1 EP300 TP53 PIP4K2A PIP4K2B BRD7 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM POLR2E POLR2F POLR2G POLR2H POLR2I NCBP2-1 POLR2L GTF2F1 GTF2F2 FGF1 POLR2J;POLR2J2;POLR2J3 FGF2 FGFR2 NCBP1 POLR2A POLR2B POLR2C POLR2D TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses RAC1 SLC38A1 SLC6A12 RPS6KA1 GLS2 ALDH2 ACTN2 GRIN2C SRC PPM1E PPM1F GRIN1 GRIN2D GRIN2A DLG2 CAMK4 NEFL CAMK1 NRAS MAPK1 HRAS MAPK3 PRKCA PLCB3 PDPK1 PLCB1 PLCB2 MAOA PRKAA1 PRKAA2 PRKAR1A MYO6 CALM3;CALM1 SNAP25 SYT1 STX1A VAMP2 SLC5A7 CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 GRIA2 CHRNA5 CHRNA4 GNGT1 CHRNA6 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD GIT1 GNG10 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 SLC6A3 GNB3 GNB5 AP2A1 KPNA2 GAD1 GAD2 GNAT3 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 PRKAR2B CAMK2B CAMK2D CAMK2A CAMK2G ADCY4 PRKAR2A GNAI3 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 RPS6KA3 GNAI2 RPS6KA2 ADCY5 MDM2-2 AKAP5 GLS ABAT ARL6IP5 PRKCB GLUL GRIN2B UNC13B CACNA2D1 SLC6A13 CACNA2D3 CACNA2D2 SLC6A11 SLC22A2 SLC22A1 ACHE GRIP1 RPS6KA6 SLC6A1 SLC6A4 NSF PRKCG SLC18A2 SLC18A3 CASK SLC32A1 GRIP2 SYN3 GRIA1 SYN2 LIN7A SYN1 LIN7C ALDH5A1 LIN7B EPB41L1 SLC17A7 TSPAN7 BCHE RAB3A GRIA3 RIMS1 GRIA4 GRIN3B PPFIA1 PPFIA4 GNAL GRIN3A PPFIA3 PPFIA2 NBEA GABRB3 CACNB1 GABRB2 CACNB2 GABRB1 CACNB3 CACNB4 HSPA8 RASGRF2 NAAA RASGRF1 KIF17 CHAT CACNA1B NRGN GABRR3 CACNA1A GABRR2 CPLX1 GABRR1 CACNA1E GABRG3;GABRG2 LRTOMT NPTN DNAJC5 NRG1 TSPOAP1 HTR3A HTR3B PICK1 CAMKK1 CAMKK2 GLRA1 COMT CACNG8 GLRA2 GLRA3 CACNG2 CACNG3 KCNJ2 CACNG4 KCNJ3 KCNJ12;KCNJ18 KCNJ4 GABRA2 GABRQ GABRA1 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 GABRA6 GABRA5 KCNJ9 GABRA4 GABRA3 PRKAB2 KCNJ15 KCNJ16 PRKAB1 GLRB APBA1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 PRKAG1 SLC1A7 PRKAG2 SLC38A2 PRKAG3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) POLD2 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 UBA52 DDB1 XRCC1 LIG3 CUL4A CUL4B YY1 RPS27A UBB;UBC RBX1 COPS5 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RUVBL1 NFRKB PARP2 ACTR5 PIAS3 USP45 RAD23A UBE2I CHD1L ACTR8 ERCC5;BIVM-ERCC5 RAD23B PARP1 INO80C INO80B GTF2H1 INO80E INO80D PIAS1 XPA GTF2H3 COPS7B ACTB-1 COPS7A GTF2H4 XPC CDK7 UBE2V2 TFPT SUMO1 MCRS1 ERCC3 SUMO3 INO80 ERCC2 SUMO2 GPS1 COPS3 MNAT1 COPS6 ERCC4 ERCC1 COPS8 POLK POLE COPS4 CETN2 COPS2 RFC5 RFC3 RFC4 RFC1 RFC2 LIG1 ACTL6A PCNA POLD3 RNF111 DDB2 POLD4 UBE2N POLD1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation TERF2IP H2BC21 H2AZ2;H2AZ1 H2AJ TERF1-1 H2AC14 MPG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 NTHL1 TDG MBD4 H2BC1 SMUG1 NEIL3 NEIL2 NEIL1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 TERF2 POT1 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism HMGCL ACSS3 BDH2 BDH1 OXCT1-1 HMGCS2 HMGCLL1 AACS ACAT1 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis OCA2 SLC45A2 DCT TYRP1 TYR DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication POLD2 RPA1 RPA2 POLE4 H2AJ RPA3 POLE2 POLE3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 H2BC5 UBE2D1 ANAPC10 ANAPC11 H2BC1 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 H2AC4 KPNB1 ANAPC2 FZR1 SKP2 CCNE2 CCNE1 CDK2 H2BC21 H2AZ2;H2AZ1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 GINS1 GINS2 CDC45 LIG1 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CCNA2-1 CCNA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 CDC7 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDC6 H2AC14 KPNA1 POLE RFC5 GMNN KPNA6 RFC3 POLRMT RFC4 POLG2 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDT1 FEN1 RFC2 MCM10 TOP3A POLG ORC5 TWNK ORC4 DBF4 ORC6 MGME1 ORC1 RNASEH1-1 DNA2 MCM8 EXOG ORC3 H2AC20 SSBP1 ORC2 H2AB2;H2AB3;H2AB1 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF3F EIF3D EIF3A EIF3B RPS15 RPS14 RPS17 EIF4EBP1 RPS16 RPS19 EIF4E RPS18 EIF4B RPS11 EIF4G1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS27A RPS25 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 PABPC1;PABPC3 RPS2 FAU EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPS27 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 GYS2 GYG2 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling PTPN11 HRAS FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 SOS1 FRS3 FGF20 FGF23 FGF22 NRAS FGF10 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) POLD2 RBBP8 ATRIP BARD1 PPP4R2 XRCC2 TIPIN XRCC3 TIMELESS RPA1 BRCC3 RPA2 PPP4C PALB2 CLSPN SLX1A;SLX1B TP53BP1 POLE4 BABAM1 RAD50 BABAM2 RAD51 UIMC1 RPA3 ABRAXAS1 POLE2 RNF8 POLE3 RAD17 RNF168-1 ATM NSD2 RAD52 RAD1 RAD9B RAD9A ATR H2BC5 H2BC1 MDC1 CDK2 H2BC21 UBE2V2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 LIG1 CCNA2-1 CCNA1 SIRT6 RNF4 UBA52 RPS27A UBB;UBC SEM1 PIAS4 UBE2I SUMO2 ERCC4 ERCC1 MUS81 MRE11 BRCA1 BRCA2 KAT5 EME2 EXO1 CHEK1 POLK NBN TOPBP1 POLE POLH GEN1 RFC5 RMI2 RFC3 RFC4 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RMI1 RFC2 TOP3A HUS1 ABL1 SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 RTEL1 BLM C1orf112 EME1-1 PCNA RAD51AP1 POLD3 POLD4 HERC2 WRN BRIP1 SLX4 FIGNL1 UBE2N POLD1 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 SIRT1 NCOR1 TBL1XR1 CARM1 RORA CLOCK RXRA PPARA ATF2 CRTC2 SMARCD3 CRTC3 RORC HDAC3 RORB CHD9 CRTC1 NPAS2 ARNTL HELZ2 RAI1 TGS1 NRIP1 EP300 PPARGC1A MEF2D NCOA1 MED1 NCOA2 MEF2C CREBBP NCOA6 NR1D1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events CAMKK2 MAPK1 CAMK2G PRKCA PLCB3 PLCB1 PLCB2 ADCY4 PRKAR2A GNAQ ADCY3 PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 PDE1C ADCY7 KPNA2 PDE1B PDE1A ADCY6 PRKAR1A GRK2 ADCY5 PRKCD PLA2G4A PRKCG AHCYL1 PRKACA-1 ADCY9 PRKACB-1 PRKAR1B NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A GNA14 PLCB4 ITPR1 GNA15 ITPR2 GNA11 ITPR3 CAMKK1 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines JAK2 WDR5 CARM1 SMARCB1 ARID2 H2AZ2;H2AZ1 H2AJ SMARCC1 SMARCC2 RPS2 H2AC14 SMARCD1 SMARCD2 PRMT7 PRMT3 H2AC16;H2AC11 RBBP7 COPRS SMARCA2 SMARCD3 SMARCE1 SMARCA4 ARID1A ARID1B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 PBRM1 CCND1 H2AC20 PRMT5 WDR77 H2AB2;H2AB3;H2AB1 ACTL6B ACTL6A DNMT3A PRMT6 PRMT1 CDK4 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib CDC37 HSP90AA1 ERBIN ERBB2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer SMAD2;SMAD3 FKBP1A SMAD4 TGFBR1-1 TGFBR2 TGFB1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR CTSS TLR3 LGMN CTSB CTSV;CTSL HSP90B1 CTSK TLR9 UNC93B1 TLR8 TLR7 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement CRP CFD C1QB C3-1 COLEC11 LOC110384692;C4A;C4B_2;C4B COLEC10 CFB C1S C2 C1R FCN2;FCN1 MBL2-1 MASP1 C1QC INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade FLT3 PIK3CB MAPK1 HRAS MAPK3 PDPK1 FRS2 KLB IRS1 PDE3B PIK3CA PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 GAB1 FGF9 SOS1 AKT2 FGF20 FGF23 SHC1-1 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 FGF10 PTPN11 FLT3LG PIK3R2 PIK3R1 GRB10 INSR THEM4 INS;INS-IGF2 NRAS RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib CDC37 HSP90AA1 ERBIN ERBB2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA IKBKB IKBKG CHUK TICAM1 UBA52 TLR3 RELA RPS27A UBB;UBC TRIM32 NFKB1 CGAS CTNNB1 DDX41 NFKBIA LRRFIP1 CRCP AIM2 NFKB2 IRF7 TRIM56 PRKDC DHX9 POLR3GL IFI16 DHX36 NFKBIB STAT6 POLR3A XRCC6 POLR3B XRCC5 POLR3C TREX1 POLR3D POLR2E STING1 POLR3E POLR1C POLR2F POLR3F POLR1D POLR2H POLR3G POLR2L POLR3H POLR3K ZBP1 TBK1 IRF3 NLRP4 DTX4 MRE11 RIPK3 RIPK1 MYD88 EP300 NKIRAS1 NKIRAS2 CREBBP TRIM21 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification JAK1 PSMD8 PSMD6 PSMD7 PDCD1LG2 PSMD2 PSMD3 PSMD1 B3GNT3 CSNK2A1;CSNK2A3 CUL3 BTRC DERL3 SKP1 DERL1 DERL2 OS9 PSMC2-1 SPOP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 MIB2 PSMD14 PSMD13 CUL1 VCP-1 TUSC3 PSMA7 PSMB6 PSMB7 NEK2 PSMB4 PSMB5 PSMB2 TMEM258 PSMB3 CD274 PSMB1 RPS27A UBB;UBC ADRM1 SEL1L RBX1 PSMA2-1 CCND1 SEM1 OST4 PSMC5 PSMC6 COPS5 PSMC3 PSMC4 OSTC PSMC1 STT3A STT3B RNF185 CDK4 GSK3B YWHAG DDOST DAD1 PRKAA1 PRKAA2 RNF5 ERLEC1 PRKAB2 CSNK2A2 PRKAB1 CSNK2B RPN2 RPN1 PDCD1 ERLIN1 ERLIN2 PRKAG1 PRKAG2 MAGT1 PRKAG3 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport LMAN1 STX5 YKT6 TGFA AREG GOLGA2 NSF GRIA1 CTSZ SEC23A SAR1B CSNK1D SEC24B SEC24A SEC24D-1 MCFD2 SERPINA1 PPP6C TFG SEC24C PPP6R1 PPP6R3 CTSC TMED2-1 NAPA TRAPPC2L TRAPPC2;TRAPPC2B NAPB LMAN1L F5 TRAPPC6A F8 TBC1D20 TRAPPC6B GORASP1 PREB SEC22B SEC22A NAPG SEC22C RAB1A TMED10 STX17 LMAN2L RAB1B GOSR2 USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC3 TRAPPC1 TRAPPC4 TRAPPC10 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 SEC13 COL7A1 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants FLT3 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors H2BC21 H2AZ2;H2AZ1 H2AJ MBD3 G6PC1 H2AC14 GATAD2B GATAD2A HDAC2 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 RBBP7 HDAC1 PCK1 H2BC1 CHD4 CHD3 MTA1 H2BC15;H2BC3;H2BC11;H2BC12 MTA3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 MTA2 FBP1 NR2C2 ZNF592 CHD5 IKZF1 H2AC20 IKZF2 IKZF3 PHF6 H2AB2;H2AB3;H2AB1 ZMYND8-1 ZNF827 ZNF687 TCF19 MBD2 NR2F2 CDK2AP2 CDK2AP1 ZNF532 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS CYP19A1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ RASGRP1 DAGLB DGKK DGKI DGKH PRKCD MGLL TRPC7 PRKCQ ITPR1 RASGRP2 TRPC6 ITPR2 TRPC3 ITPR3 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CAMK4 CALM3;CALM1 PRKACA-1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H POLR2I POLR2L GTF2H1 TAF8 GTF2F1 TAF4B GTF2H3 TAF7 GTF2F2 TAF6 GTF2H4 TAF5 CDK7 TAF4 POLR2J;POLR2J2;POLR2J3 TAF3 ERCC3 TAF2 ERCC2 TAF1 MNAT1 GTF2B TAF7L TBP GTF2A1 GTF2A2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH TAF9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C TAF15 POLR2D TAF12 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling FGF3 FGFRL1 FGF4 FGF23 SPRED2 FGF22 SPRED1 FGF18 FGF2 FGF10 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors RXFP4 RLN3 RLN2;RLN1 INSL3 RXFP1 INSL5 RXFP2 RXFP3 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 SEM1 RHNO1 BLM RAD51AP1 WRN BRIP1 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle ARHGAP21 MCAM ARHGAP39 MCF2 ERBIN VANGL1 ARHGAP32 DIAPH3 ACTC1;ACTG2 RTKN SOWAHC ARHGEF10L AKAP13 STK10 SLK ARHGEF11 TFRC ARHGEF10 ARHGEF12 STARD8 ARHGEF17 CIT RHOB DAAM1 ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 PKN3 CAV1 ARHGEF28 IQGAP3 STOM RHPN2 ECT2 STARD13 JUP CAVIN1 PCDH7 MYO9A NET1 ANLN TJP2 DIAPH1 DLC1 PKN2 PKN1 VAV2 ROCK1 SNAP23 ROCK2 FLOT1 FLOT2 BCR ARHGAP1 PIK3R2 ABR ARHGDIG PIK3R1 RACGAP1 ARHGAP5 ARHGAP35 PREX1 OPHN1 MYO9B MCF2L ARHGAP26 DEPDC1B ARHGEF5 VAMP3 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 RAC1 SOS2 BUB1B-PAK6;PAK6 PAK5 PAK4 SLIT2 ROBO1 PAK1 SOS1 PAK3 NCK2 PAK2 NCK1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events GNB1 ARHGEF26 GNB4 GNB3 GNB5 KALRN VAV1 MCF2 TIAM1 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 RHOB ARHGEF3 ARHGEF1 ARHGEF2 BTK ECT2 RASGRF2 NET1 VAV3 GNGT1 ADRA1D ADRA1B ADRA1A ARHGEF40 PLEKHG2 ARHGEF15 VAV2 PLEKHG5 ARHGEF19 RHOC TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 FGD1 FGD2 ARHGEF18 FGD3 GNA13 ROCK1 FGD4 ROCK2 TBXA2R RHOA GNA12 ARHGEF33 ARHGEF37 SOS1 ARHGEF39 ARHGEF38 PLXNB1 GNG10 GNG2 GNG5 SOS2 GNG4 TRIO GNG8 ITSN1 ABR PREX1 MCF2L ARHGEF16 ARHGEF5 GNG13 GNB2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids ACOT8 EHHADH-1 ACAA1-1 HSD17B4 DECR2 ABCD1 SLC27A2 ACOT4 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease FIP1L1 PIK3CB BIN2 KDR HRAS PIK3R2 PIK3R1 KANK1 PIK3CA SOS1 STRN GOLGA4 WDR48 STAT1 PDGFRA STAT3 NRAS ETV6 S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase POLD2 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RB1 CDKN1A CDKN1B FZR1 CCND1 E2F1 SKP2 TFDP1 TFDP2 CCNE2 CDK4 CCNE1 GSK3B CDK2 SMC3 RBBP4 CDCA5 PDS5B PDS5A RAD21 WAPL STAG1 STAG2 RBL2 GINS1 GINS2 CDC45 LIG1 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CCNA2-1 SMC1A CCNA1 E2F4-1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 CDC25B PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CCNH MAX CDC6 CDK7 MNAT1 AKT2 MYC AKT3 AKT1 POLE ESCO1 ESCO2 RFC5 GMNN PTK6 LIN54 RFC3 CKS1B RFC4 LIN52 RFC1 CDT1 LIN37 FEN1 RFC2 LIN9 CABLES1 WEE1 ORC5 ORC4 ORC6 ORC1 DNA2 MCM8 ORC3 ORC2 E2F5 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors DRD4 DRD5 TAAR8 HTR1E HTR1F TAAR9 TAAR6 ADRA2C HTR1D ADRA2B HTR1A ADRA2A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B ADRB1 ADRB2 HTR2A HTR4 HRH1 HTR6 HTR7 HRH3 HRH2 HRH4 ADRA1D DRD1 ADRA1B DRD2 ADRA1A DRD3 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair POLD2 RBBP8 ATRIP BARD1 PPP4R2 XRCC2 TIPIN XRCC3 TIMELESS RPA1 BRCC3 RPA2 PPP4C PALB2 CLSPN SLX1A;SLX1B TP53BP1 POLE4 BABAM1 RAD50 BABAM2 RAD51 UIMC1 RPA3 ABRAXAS1 POLE2 RNF8 POLE3 DCLRE1C RAD17 RNF168-1 RIF1 ATM NSD2 LIG4 RAD52 RAD1 KPNA2 PAXIP1 RAD9B NHEJ1 RAD9A XRCC4 ATR SMARCA5 PPP5C TDP2 TDP1 BAP1 UBXN1 H2BC5 POLL BAZ1B XRCC1 APBB1 LIG3 KDM4A H2BC1 POLQ EYA1 POLM EYA2 EYA3 EYA4 PRKDC MDC1 XRCC6 XRCC5 CDK2 H2BC21 PARP1 KDM4B UBE2V2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 LIG1 CCNA2-1 CCNA1 MAPK8 SIRT6 RNF4 UBA52 RPS27A UBB;UBC TP53 SEM1 PIAS4 PARP2 UBE2I SUMO1 SUMO2 ERCC4 ERCC1 MUS81 MRE11 BRCA1 BRCA2 KAT5 EME2 EXO1 CHEK1 POLK NBN TOPBP1 POLE POLH GEN1 CHEK2 RFC5 RMI2 RFC3 RFC4 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RMI1 FEN1 RFC2 TOP3A HUS1 ABL1 SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 RTEL1 BLM C1orf112 EME1-1 PCNA RAD51AP1 POLD3 POLD4 HERC2 WRN BRIP1 SLX4 FIGNL1 UBE2N POLD1 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function SP1 HEYL AGO3;AGO1 TNRC6A-1 TNRC6C ZEB2 ANGPTL4 PRDM8 BHLHE22 TNRC6B CDH8 CTNNA1 CDH24 HOXC8 FOXF1 CTNND1 ADAM33 ADAM19 ILF3 MOV10 CDH11 AGO4 SNAI1 CTNNB1 JUP AGO2 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis GLB1 NEU1 CTSA SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 MAMLD1 PSENEN PSEN2 PSEN1 APH1A EGFR NCSTN APH1B HES5 HEYL EGF UBA52 STAT1 MIB2 YBX1 SNW1 JAG2 WWP2 NOTCH3 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B HEY1 RPS27A FABP7 NEURL1 UBB;UBC KAT2B KAT2A NOTCH1 MAML2 HEY2 HES1 MAML1 PLXND1 EP300 WWC1 DLGAP5 PTCRA PBX1 TACC3 CREBBP RBPJ POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS JAK2 JAK1 NFE2L2 VAV1 MBD3 CUL3 AP2A1 AP2A2 FKBP1A GATAD2B GATAD2A HDAC2 AP2M1 BRD4 ACE2 HDAC1 TLR7 MTA1 CYSLTR1 MTA3 SH3KBP1 BTK AP2S1 ATP1B2 ATP1B1 RBX1 PLCG2 ARID4A ARID4B AP2B1 FNTA ATP1A4 BLNK KDM1A HMG20B JAK3 ATP1A3 IL1R1 FKBP4 ATP1A2 IFNGR1 IFNGR2 SIGMAR1 ATP1A1 COMT TYK2 SAP30 IMPDH1 BRMS1 HSP90AA1 IFNAR1 IMPDH2 NR3C1 PHF21A ATP1B3-1 CD79B SYK PTGES3-1 CD79A SAP30L FXYD2;FXYD6-FXYD2 S1PR1 TUBB4A;TUBB;TUBB8B;TUBB8 SAP18 SUDS3 ZBP1 CRBN FXYD4 HSP90AB1 TBK1 STAT2 FXYD3 ROCK1 RCOR1 ROCK2 FXYD1 FNTB;CHURC1-FNTB FXYD6 SOS1 RBBP4 NCK1 TLR9 RBBP7 ITGB1 CHD4 CHD3 ITGA4 PDCD1 MTA2 IL6R RIPK1 REST KEAP1 FURIN PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs FIP1L1 NCBP2-1 CPSF4 CPSF2-1 CPSF1 CSTF3 CPSF3 CSTF2 NCBP1 CSTF2T WDR33 NUDT21 PABPN1-1 CLP1 PCF11 PAPOLA SYMPK CPSF7 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea CASK EPB41L1 MYH9 CHRNA9 TWF1 SPTAN1 RIPOR2 CLIC5 MYO1C CIB2 PJVK EPS8 TPRN PLS1 TMC1 ESPN-1 MYO7A TMC2 MYO3B MYO3A KCNMB1 KCNMA1 KCNQ4 FSCN2 CHRNA10 PCDH15 KCNN2 USH1C ESPNL EZR CDH23 OTOG XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 GSN WHRN LHFPL5 SPTBN1 OTOGL TMIE USH1G RDX STRC MSN MYO15A SLC26A5 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS SFTPC IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR HBEGF TGFA EGFR EGF AREG EREG BTC EPGN POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription SP1 KLF9 FOXJ2 STRAP ZEB2 FOXP2 TFAP2A KLF4 ARID1A RB1 FOXA2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF4 FGF6 FGF9 FGFR1 FGF20 FGF23 FGF1 FGF2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 SLC12A6 SLC12A7 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) B4GALT1 FMOD OMD PRELP ACAN OGN LUM KERA DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD8 PSMD6 PSMD7 PSMD2 HSPB1 PSMD3 PSMD1 PABPC1;PABPC3 EIF4G1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 HSPA8 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 HSPA1A;HSPA1B SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors HSP90B1 FTL-1 FTH1 COLEC11 COLEC12 MSR1 MASP1 SCARA5 MARCO SCGB3A2 COL3A1 APOB COL4A2 COL4A1 CALR-1 APOE APOA1 COL1A1 COL1A2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MDM2-2 TSC2 AKT1S1 MKRN1 CDKN1A CDKN1B CHUK BAD CASP9 AKT2 AKT3 AKT1 GSK3A GSK3B DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids GLYATL3 ACSM5 GLYAT ACSM4 ACSM1 ACSM2A;ACSM2B RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle ARHGAP21 PAK4 MPP7 LAMTOR1 GJA1 PAK1 VANGL1 ARHGAP32 DIAPH3 PAK3 CPNE8 PAK2 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CDC42BPB CDC42BPA TFRC SLC4A7 WIPF2 FMNL3 CAV1 IQGAP3 STOM JUP STEAP3 WASL ARHGEF7 WAS SNAP23 SYDE1 CDC42 GIT1 ARL13B OCRL TRIO ARHGAP1 PIK3R2 PIK3R1 WWP2 ARHGAP5 ARHGAP35 PREX1 OPHN1 GIT2 ARHGAP26 TMPO SLC1A5 DEPDC1B CDC42EP1 VAMP3 RAB7A SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 SPINT1 HPN MST1 SPINT2 MST1R CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions CDH11 CTNNB1 JUP CDH8 CTNNA1 CDH24 CTNND1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism MAT1A GOT1-1 GOT2-1 GADL1 APIP MRI1 CSAD ADO TXN2 CBS;CBSL ENOPH1 MPST TSTD1 BHMT2 SQOR FMO1 SUOX MTAP BHMT TST MTRR ADI1 AHCY ETHE1 CTH SLC25A10 MTR-1 CDO1 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X ABCE1 RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 RPL4 RPL30 RPL3 RPL32 RPL31 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins CTR9 WDR61 RTF1 RRAGA CDC73 TMEM129 HLTF LEO1 RNF152 UBE2J2 SHPRH PEX10 PEX2 PEX12 PEX13 PEX14 UBE2V2 RNF40 RNF144A DERL1 SELENOS WAC-1 RNF181 PAF1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 UBE2E1 UBA52 UBE2D1 RNF20 UBE2B HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E H2BC1 VCP-1 RAD18 BCL10 UBE2D3-1 H2BC15;H2BC3;H2BC11;H2BC12 RPS27A UBB;UBC PCNA PRKDC UBE2D3;UBE2D2 UBE2N TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 TICAM2 TICAM1 CD14 TLR7 MAP3K8 NFKB2 IRF7 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D SLC15A4 MEF2C MAPK9 MAPK8 TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB PIK3R4 CASP8 EEA1 TASL RBSN IRF5 RPS6KA5 TRAF2 TLR9 PIK3C3 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry ATG7 AP2A1 AP2A2 UBA7 UBA6 UBA5 GPC1 AP2M1 HSPG2 CLEC4M;CD209-2 GPC3 CD14 PROS1 CLDN1 CD33-1 GPC2 SDC4 MRC1 GPC5 SDC2 EMC4 GPC4 HSPA5 SDC3 GPC6 TIMD4 MERTK AXL TYRO3 AGRN RPSA MAPRE3 GAS6 PIK3R1 LY6E UBA3 SDC1 AP2S1 UBA1 FURIN AP2B1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) ALOX5 ABCC1 ALOX15 CYP4B1 CYP4F22 GGT1 ALOX5AP PTGR1-1 DPEP2 DPEP1 LTA4H MAPKAPK2 LTC4S CYP4F3;CYP4F2;CYP4F12;CYP4F11 GGT5 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L SUPT5H TCEA1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H CTDP1 POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation SMARCB1 MAPK14 ACTB-1 SMARCC1 USF1 SMARCC2 GPR143 LEF1 TFAP2A SMARCD1 AKT2 SOX10 SMARCD2 SMARCA2 SMARCD3 SMARCE1 SMARCA4 DCT TYRP1 TYR ARID1A ARID1B PMEL BCL7A MLANA BCL7C DPF1 BCL7B CTNNB1 DPF2 DPF3 SS18 SS18L1 ACTL6A RAB27A MYRIP SYTL2 MLPH IRF4 MYO5A ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport BEST3 SLC9C2 BEST1 BEST4 ATP11C ATP11B ATP11A SLC9B1 SLC9B2 SCNN1G CLCA4-1 SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 WNK4 NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B ATP4A WNK1 WNK3 CUTC UNC80 RYR1 CLCNKA;CLCNKB RYR2 ATP7B ATP7A CLCN6 ATP2A3 TSC22D3 ATP2A2 ANO8 ATP2A1 ANO9 RYR3 ANO6 ANO4 ANO5 ANO2 ANO3 CLIC2 ANO1 STOML3 ATP1B2 ATP10D ATP1B1 ATP10B TRDN ATP10A ASPH ATP2C2 ATP2C1 CLCN3 CLCN2 CAMK2B CLCN1 CAMK2D BSND CAMK2A ANO10 ATP1A4 SGK3;C8orf44-SGK3 ATP9B ATP9A ATP1A3 ATP13A1 ATP1A2 TPCN2 TPCN1 SRI CLCN7 ATP1A1 CLCN5 CLCN4 CAMK2G OSTM1 ATP13A4 ATP13A5 ATP1B3-1 ATP13A2 ATP2B4 UNC79 ATP2B3 FXYD2;FXYD6-FXYD2 ATP2B2 ATP2B1 FXYD4 FXYD3 FKBP1B FXYD1 FXYD6 PDZD11 SGK1-1 NEDD4L RAF1 CALM3;CALM1 UBA52 TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 RPS27A ATP6AP1 UBB;UBC STOM TRPM1 TRPM2 ATP6V1B2 ATP6V0D1 TRPM7 ATP6V0D2 TRPM8 TRPM5 ATP6V0C TRPM6 TRPM3 ATP6V1B1 ATP6V1A TRPM4 TRPC7 TRPC5 MCOLN3 ATP6V0A2 TRPC6 ATP6V1H TRPC3 ATP6V0A4 TRPA1 TRPC4 ATP6V1G3 ATP6V1D TRPC1 TRPV2 ATP6V1C1 TRPV3 ATP6V1C2 TRPV1 WWP1 ATP6V0A1 MCOLN1 TRPC4AP ATP6V1F MCOLN2 TRPV6 TRPV4 TRPV5 ATP6V0E2;ATP6V0E1 ATP8A2 ATP8A1 ATP12A BEST2 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors PIAS3 MDM2-2 UBE2I MTA1 FOXL2 HIC1 PIAS1 SP3 TP53BP1 CDKN2A SUMO1 SUMO3 SUMO2 TP53 MITF TFAP2C TFAP2E;TFAP2B PIAS4 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NPM1-2 TFAP2A MYBL2 NOP2 HSPD1 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A RAD51B RAD51D RAD51C DNA2 SEM1 BLM RAD51AP1 WRN BRIP1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 N6AMT1 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A TRMT112 RPLP2 RPL36-1 RPS3A GSPT2 RPL13A-1 GSPT1 APEH RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ETF1 RPS27 RPL4 RPL30 RPL3 RPL32 RPL31 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L NCBP2-1 CCNT2-1 GTF2H1 SUPT5H TCEA1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 CCNK CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CTDP1 CCNH POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions PTCH1 DHH IHH HHIP BOC SHH GAS1 CDON LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis POLD2 RFC5 RFC3 RFC4 RFC1 RFC2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA PLD1 PLA2G1B LPCAT1 ALPG;ALPP;ALPI-1 PLA2G5 PLD6 AGPAT1 LCLAT1 AGPAT2 PLA2G2A-1 AGPAT3 PLA2G4A AGPAT4 PLD2 GPAT4 LIPI ACP6 LIPH AGPAT5-1 GPAT3 JMJD7-PLA2G4B;PLA2G4B GPAT2 PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLA2G12A PLA2G2E MIGA2 MIGA1 PLA2G4D DDHD2 GPD1L-1 DDHD1 GNPAT LPCAT4 GPD2 GPD1 PLA2R1 GPAM ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion TSG101 MVB12B MVB12A VPS37C PPIA VPS37D VPS37A RPS27A UBB;UBC VPS37B UBAP1 NMT2 VPS28 FURIN UBA52 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility HBEGF EGFR ERBB2 RHOA MEMO1 NRG2 NRG3 NRG4 DIAPH1 EGF NRG1 EREG BTC TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) SV2C SV2B SV2A VAMP1 VAMP2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity PRKAA2 ADIPOQ ADIPOR1 ADIPOR2 PRKAB2 PRKAG2 STK11 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression HINT1 SMARCB1 SIN3A SMARCC1 SMARCC2 GPR143 AGO3;AGO1 SOX10 SMARCD1 POU3F2 SMARCD2 PLK1 HDAC1 CCNB1 SMARCA2 SMARCA4 SMARCE1 CDKN1A TCF7 CDH1 GMPR CCND1 CTNNB1 MET STT3B MYO5A CDK2 MAPK14 USF1 LEF1 TFAP2A TCF7L2 TCF7L1 TNRC6A-1 SMARCD3 TNRC6C ARID1A TNRC6B ARID1B LIG1 SERPINE1 MCM5 MCM2 PPARGC1A ACTL6A GXYLT2 CDH2 PXN TERT EDIL3 ZEB1 PXDN SIRT1 BIRC7 ASAH1 BCL2A1 TBX2 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 CDKN2A BCL2 CDC25B SOX2 ATP6V1E1 ATP6V1G1 ATP6V0B DICER1 TRPM1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A DIAPH1 ATP6V1H ATP6V1C1 ATP6V0E2;ATP6V0E1 ACTB-1 AKT2 BRCA1 DCT ITGA2 TYRP1 TYR PMEL BCL7A MLANA MOV10 BCL7C DPF1 AGO4 BCL7B DPF2 AGO2 DPF3 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE TLR3 TICAM1 TRAF3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer NCOR1 PSENEN TBL1XR1 PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SKP1 HDAC5 HDAC2 UBA52 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 MIB2 CUL1 SNW1 JAG2 JAG1 ADAM10 HDAC10 DLL1 HDAC11 MIB1 DLL4 NEURL1B ADAM17 NCOR2 RPS27A NEURL1 KAT2B UBB;UBC KAT2A NOTCH1 RBX1 RBPJ HDAC4 MAMLD1 CCNC-1 MYC HDAC3 HEY1 MAML2 HEY2 HES1 MAML1 EP300 CDK8 CREBBP PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2E POLR2F POLR2G POLR2H POLR2I PIWIL2 POLR2L HSP90AA1 PIWIL1 PIWIL4 DDX4 HENMT1 ASZ1 MAEL TDRKH-1 MOV10L1 MYBL1 POLR2J;POLR2J2;POLR2J3 TDRD9 TDRD6 TDRD1 TDRD12 PLD6 FKBP6 POLR2A POLR2B POLR2C POLR2D SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling HRAS SOS1 IRS1 IRS2 NRAS INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells CDH1 CTNNB1 CBLL1 UBA52 SRC CTNND1 RPS27A UBB;UBC APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PTTG1;PTTG2 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 UBE2S CDC26 CDC16 CDC27 PSMA7 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDC20 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy PCNT EEF1A1 HSP90AA1 HBD;HBB RPS27A HSP90AB1 UBB;UBC PLIN3 HSPA8 CETN1 PARK7 RNASE1 GFAP IFT88 LAMP2 ARL13B PLIN2 UBA52 CFTR HDAC6 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals MT2A MT3 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair NEIL3 NEIL1 OGG1 NTHL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters LEF1 CTNNB1 MYC RUNX3 TCF7L2 TCF7L1 AXIN2 TCF7 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle LIG4 XRCC4 XRCC6 XRCC5 NUP107 NUP160 RAN NUP85 CXCR4 CD4 TSG101 VPS4B VPS4A MVB12B CCNK MVB12A CCNT1 VTA1 ELL GTF2B VPS37C ELOC-1 VPS37D LIG1 TAF7L VPS37A ELOA XPO1 ELOB VPS37B NELFB UBAP1 NMT2 NELFA SEC13 VPS28 NELFCD NELFE NUP133 CHMP5 SUPT16H TBP FURIN NCBP1 GTF2A1 RANGAP1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 NEDD4L CCNT2-1 NUP43 TAF8 TCEA1 TAF4B TAF7 PPIA TAF6 TAF5 TAF4 RANBP2 TAF3 TAF2 TAF1 UBA52 RCC1 NMT1 CCR5 NUP37 RANBP1 RPS27A UBB;UBC GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 NUP205 NUP188 PSIP1 PDCD6IP AAAS NUP42 NUP62 TPR BANF1 NUP88 CHMP4C RAE1 KPNA1 CHMP4B NDC1 NUP214 CHMP3 NUP210 CHMP4A NUP155 NUP153 CHMP6 NUP93 CHMP7 NUP50 POM121;POM121C NUP35 NUP54 FEN1 CHMP2B CHMP2A DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC38A1 GLUL SLC1A2 SLC1A3 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 MAPK14 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 MAPK11 EXOSC1 DCP2-1 YWHAZ AKT1 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC UNC5A UNC5B MAGED1 CASP3 CASP9 DAPK2 DAPK3 APPL1 DCC DAPK1-1 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome WDR5 RBBP5 KMT2D ASH2L DPY30 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation MLST8 PDPK1 PPP2R1B PPP2R1A CDKN2A ATM AKT2 RICTOR AKT3 RNF34 AKT1 USP7 USP2 UBA52 MDM2-2 RFFL MAPKAP1 MTOR PHF20 CHEK2 CDK1 PPP2CB;PPP2CA RPS27A UBB;UBC TP53 SGK1-1 MDM4 DAXX PPP2R5C CCNA2-1 PRR5 CCNA1 CCNG1 CDK2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS AGRN EXT1 EXT2 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 GPC5 SDC2 GPC4 SDC3 GPC6 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase CSNK2A1;CSNK2A3 AKAP9-1 PLK1 CCNB1 CDK1 NEK2 CCP110 PRKACA-1 CEP250 CDK5RAP2 CEP135 CSNK1D PRKAR2B ERCC6L NUP107 ZWILCH BUB1B SMC3 HSP90AA1 PMF1;PMF1-BGLAP YWHAG CDC20 CEP70 PPP1CC PPP2R1B CEP72 PPP2R1A CEP192 KNTC1 KNL1 SGO1 DYNC1LI1 CEP76 SGO2 CEP78 CLIP1 EML4 DYNC1LI2 PLK4 ZW10 MAD1L1 ODF2 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 CEP57 RAD21 RCC2 NDC80 CETN2 WAPL CEP164 ZWINT KIF18A STAG1 STAG2 RPS27 ACTR1A AHCTF1 PPP2CB;PPP2CA MAPRE1-1 CNTRL PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A CEP290 PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B HAUS4 ITGB3BP PAFAH1B1 NEK9 HAUS3 DYNC1I2 NEK6 HAUS6 CENPA NEK7 HAUS5 AURKB TUBG1 NSL1 CENPC NUP43 HAUS2 BUB3 HAUS1 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CEP63 CENPE CENPF YWHAE CENPH CENPI TAOK1 TUBA1A DCTN2 CENPK SSNA1 CENPJ CENPL DCTN3 CENPM B9D2 CENPO CENPP HAUS8 CENPQ HAUS7 SPC24 SPC25 PCNT MAD2L1 OFD1-1 NUP37 CEP152 NEDD1 TUBA4A ALMS1 CEP41 CEP43 SMC4 SMC2 TUBGCP2 MZT2A;MZT2B NCAPG NCAPH TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 NUMA1 TUBG2 NME7 MZT1 NCAPD2 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CSNK2A2 CSNK2B C1orf112 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases NOXO1 MAPK1 RAC1 MAPK3 S100A9 S100A8 PRKCA MAPK14 PIK3R4 NCF1 MAPK11 NCF2 PRKCZ NCF4 NOXA1 NOX3 PRKCB NOX1 PIN1 PRKCD CYBB PIK3C3 CYBA REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 TREX1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ECHS1 ACSM3 HADH ACADS CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM5A STPG4 H2AJ UHRF1 AICDA METTL23 DPPA3 TET3 H2AC20 KDM6A H2AC14 H2AB2;H2AB3;H2AB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KDM6B H2BC5 KDM5B H2BC1 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia PROC PROS1 F5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation POLR3E POLR2E POLR1C POLR2F POLR3F POLR1D POLR2H POLR3G POLR3H POLR2L POLR3K CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation IFNB1-4 TBK1 IRF3 EP300 DDX58 IFIH1 TANK RNF135 IRF7 SIKE1 MAVS TRAF6 TRIM25 IKBKE TRAF2 CREBBP LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 TMPRSS2 MGAT5 ACE2 ST3GAL4 UBA52 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS TUSC3 GOLGA7-1 MGAT4C ZDHHC9 MGAT4B ANO8 MAN1B1 ANO9 ST6GALNAC3 ANO6 ST6GALNAC4 ANO4 ANO5 TMEM258 ANO2 ANO3 RPS27A ANO1 UBB;UBC OST4 OSTC STT3A ANO10 STT3B GSK3A PARP6 PRMT1 PARP4 GSK3B GALNT1 PARP16 PARP9 UBE2I PARP14 PARP8 PARP10 CANX DDOST CSNK1A1 DAD1 SUMO1 SRPK2 SRPK1 RPN2 RPN1 FURIN MAGT1 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u DPM1 DPM2 DPM3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 UBE2D3-1 TLR4 BIRC2 LY96 BIRC3 IKBKB RIPK1 RPS27A IKBKG UBB;UBC CHUK TICAM2 TICAM1 RIPK3 TRAF6 CD14 UBE2V1 UBA52 UBE2D1 UBE2D3;UBE2D2 UBE2N RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry NCL-1 RAB5A AGRN TLR4 LY96 EGFR SDC1 FURIN GPC1 HSPG2 GPC3 CD14 GPC2 CX3CR1 SDC4 GPC5 RAB5B SDC2 GPC4 RAB5C SDC3 IGF1R GPC6 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine TERF2IP NEIL3 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 ACD H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ TERF1-1 H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 MPG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 TERF2 H2BC1 POT1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus PIP4P1 PIP4K2A PIP4K2B O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes HBA2;HBA1 CYB5R2 CYB5R1 CYB5R4 CA1 CA2 CA4 RHAG HBD;HBB SLC4A1 CYB5RL AQP1 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels KCNV2 GNB1 KCNMB2 GNB4 KCNMB3 GNB3 KCNN1 GNB5 KCNMB4 KCNN3 KCNN4 KCNF1 KCNK9 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 HCN1 KCNK4 ABCC9 KCNJ11 KCNMB1 KCNQ2 KCNQ4 KCNMA1 KCNN2 KCNQ3 GNGT1 KCNJ8 ABCC8 KCNJ2 KCNJ3 KCNJ12;KCNJ18 KCNJ4 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 KCNJ9 KCNJ15 KCNJ16 GNG10 GNG2 KCNK6 GNG5 KCNK7 GNG4 GNG8 KCNK1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNK10 KCNH6 KCNH7 KCNH8 KCNK13 KCNK16 KCNK18-1 KCNK17 GNG13 KCNQ1 GNB2 KCNQ5 KCNV1 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction TPM1 SORBS1 SORBS3 MYLPF MYL5 MYL6 MYL7 TLN1 VCL CALM3;CALM1 PAK1 PAK2 ALDH2 ITGA1 PDE5A TRIM72 GUCY1B1 ITGB5 DYSF LMOD1 MYL6B CACNA1H MYL12A CACNA1G MYL12B MYLK CACNA1I CALD1 ANXA6 MYL10 MYH11 GUCY1A2 GUCY1A1 PXN ANXA1 CAV3 TPM4 ANXA2 TPM3 TPM2 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 CDC37 HRAS SOS1 HSP90AA1 SHC1-1 PTPN12 NRAS ERBIN ERBB2 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) CR1L;CR1 NFATC2 CTLA4 CBFB IL2RA RUNX1 FOXP3 TNFRSF18 IL2 IFNG BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA ACADVL HADHA HADHB-1 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b MOGS DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG GALE MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation MAP2K2;MAP2K1 CUL1 MAP3K8 IKBKB RPS27A IKBKG UBB;UBC BTRC NFKB1 TNIP2 SKP1 CHUK FBXW11 MAP2K4 UBA52 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction RAC1 PAK2 FYN DOCK2 HCK LCK ELMO1 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins C1GALT1 MUC5B MUC20 MUC21 NOTCH1 DAG1 GALNT12 SEMA5A POMT2 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 LFNG ADAMTS4 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL2 MUC12 MUC13 MUC15 THSD7A ADAMTS8 LARGE1 ADAMTS9 NOTCH2 ADAMTS6 ADAMTS7 SBSPON NOTCH3 MUC3A POMGNT1 NOTCH4 MUC5AC ADAMTS20 B3GLCT CFP B4GAT1 THBS2 THBS1 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 MUC2 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 MUC17 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling GNB1 GNB4 PIK3CG GNB3 GNB5 PDPK1 PLCB3 PLCB1 PLCB2 ARHGEF6 RHOA PAK1 CDC42 AKT2 AKT3 AKT1 GNG10 GNG2 GNG5 GNG4 GNG8 PIK3R6 PIK3R5 BTK GNGT1 GNG13 GNB2 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT7 ACY3 GGT6 MGST3 MGST1 MGST2 GGT1 AKR7A2 AKR7A3 DPEP2 DPEP1 ACY1;ABHD14A-ACY1 CYP2A13;CYP2A6;CYP2A7-1 CYP1A2 GGT5 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events EDNRB RPS6KA1 EDN1 EDN3 GRK2 PRKCD NRAS MCHR1 MAPK1 HRAS MAPK3 PRKCA PLCB3 PLCB1 PLCB2 PIK3CA SOS1 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 EGFR ABHD12 PRKCH PRKCE DGKZ DGKQ RASGRP1 DAGLB DGKK DGKI DGKH APP ARHGEF25 GNA14 GNA15 GNGT1 GNA11 ADRA1D ADRA1B ADRA1A GNAQ TBXA2R GNG10 GNG2 GNG5 GNG4 TRIO GNG8 CHRM3 CHRM1 CHRM5 GCGR HTR2B HTR2A HRH1 GCG GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 KALRN GPR143 CYSLTR1 CYSLTR2 BTK MGLL ANXA1 ITPR1 ITPR2 ITPR3 RPS6KA3 RPS6KA2 PLCB4 MAPK7 NPFFR2 NPFFR1 RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 NTSR2 HBEGF GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 OXTR NMS NMU AVPR1B GNRH1 QRFP AVP MLN AVPR1A BRS3 OXT-1 GPRC6A GPR132 CCKAR GNRHR FFAR4 GAST FFAR2 FFAR1 GPR39 EDN2 TACR2 TRPC7 TACR3 TACR1 F2 TRPC6 CCKBR TRPC3 NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR F2R LTB4R2 NTS MCHR2 KNG1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH PIK3R3 LTB4R PIK3R2 GRM1 PIK3R1 GRM5 BDKRB2 BDKRB1 QRFPR MMP3 RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK HCRTR2 HCRTR1 KISS1 SAA2;SAA1 FFAR3;GPR42 PRKCQ RASGRP2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 WAS LCK VASP HLA-DQB2;HLA-DQB1 PAK1 PAK3 PAK2 PLCG1 NCK1 ENAH EVL CD4 GRAP2 HLA-DPB1-1 PLCG2 ITK FYB1 HLA-DRA CD3G ZAP70 LCP2 LAT CD3E CD101 CD3D MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 TICAM2 TICAM1 CD14 TLR7 MAP3K8 NFKB2 IRF7 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C MAPK9 MAPK8 TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB CASP8 RPS6KA5 TRAF2 TLR9 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin VWF F2 F8 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs MOV10 CDH11 AGO4 TNRC6C AGO2 TNRC6B TNRC6A-1 AGO3;AGO1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization PIK3CB PIK3R2 SOS1 PIK3R1 SYK PDPK1 GAB2 LYN FYN PIK3CA LAT2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDK6 CDK4 CDKN2A SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis DLST DLD MRPS36 OGDH DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism BCKDHB MCCC2 DBT MCCC1 DLD PPM1K AUH IVD HIBCH ECHS1 BCKDK BCKDHA ACAT1 SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants MAP2K2;MAP2K1 JAK2 MAPK1 FGB HRAS CAMK2G FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B VCL FN1 CALM3;CALM1 CSK MARK3 SRC CAMK2B CAMK2D ITGB3 CAMK2A ARAF ARRB1 YWHAB IQGAP1 ARRB2 NRAS RAP1B RAP1A LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling NOTCH1 CUL1 RBX1 SKP1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching POLD2 RFC5 RFC3 RFC4 RFC1 RFC2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2BC21 WDR5 H2AZ2;H2AZ1 NFE2 SIN3B SIN3A H2AJ ITGA2B SETD1B AGO3;AGO1 SETD1A GATA1 H2AC14 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PF4;PF4V1-1 H2BC5 NR4A3 HDAC1 TNRC6A-1 H2BC1 CBFB TNRC6C RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 KMT2A THBS1 KMT2C KAT2B ZFPM1 MOV10 AGO4 EP300 H2AC20 H2AB2;H2AB3;H2AB1 KMT2D PRKCQ ASH2L PRMT6 PRMT1 GP1BA KMT2B DPY30 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2;SMAD3 SMAD4 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression PRDM1 TP53 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function CDH11 CTNNB1 JUP ANGPTL4 CDH8 CTNNA1 CDH24 CTNND1 ADAM33 ADAM19 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex TAB2 MAP3K7 TAB1 TLR3 TICAM1 TRAF6 UBA52 RPS27A UBB;UBC TAB3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis POLD2 RFC5 RFC3 RPA1 RFC4 RPA2 RFC1 FEN1 RFC2 LIG1 RPA3 DNA2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL PIK3CD PIK3CB PIK3R3 PIK3R2 PIK3R1 SYK LYN VAV1 PIK3CA HCK YES1 CBL RAPGEF1 CRK FYN BLNK CRKL GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RPL8 KDM8 STS OGFOD1 ARSA JMJD4 DHPS FN3KRP JMJD7 SUMF2 SUMF1 JMJD6 TPST2 F7 TPST1 F9 RCCD1 EIF5A2 U2AF2 DNAJC24 ARSL DPH1 DPH2 ARSJ ARSK ARSH ARSI DPH5 RPS6 DPH6 DPH7 ARSG EEF2 ZC3H15 RWDD1 FN3K ICMT F10 ARSB EIF5A;EIF5AL1 DOHH ARSD-1 RIOX1 GGCX RIOX2 DRG1 DRG2 ASPH RPL27A RPS23 F2 F8 PROC PROS1 ETF1 GAS6 FURIN NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR NGFR NGF HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA NUP214 SET-1 ELAVL1 ANP32A;ANP32D PRKCD PRKCA XPO1 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation EIF5A2 EIF5A;EIF5AL1 DOHH DHPS MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E UBA52 RPS27A UBB;UBC REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade CPN1 C8G C6 C7 CD19 C9 C5 CR2 C3-1 CFHR1;CFHR2 LOC110384692;C4A;C4B_2;C4B SERPING1 CFH-3 CFB C2 CR1L;CR1 VTN PROS1 CD59 CD55 C1QB C3AR1 C1S C1R C1QC ELANE CPB2 CD81 C5AR2 CFI C5AR1 C4BPA C4BPB F2 C8B C8A CLU CPN2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis AP2A1 AP2A2 GRK2 LDLRAP1 AP2M1 TGFA SH3GL3 SH3KBP1 STAM AP2S1 CBL HGS LDLR STAM2 EPS15 COPS5 SH3GL2 SH3GL1 DVL2 AP2B1 ARPC4 ARPC5 CLTC ARPC2 CLTA ARPC3 ACTR3-1 ARPC1A WASL ACTR2 ITSN2 SCARB2 AGFG1 GAPVD1 STON1-GTF2A1L BIN1 AMPH SNX18-1 GPS1 GRK3 CLTCL1 HIP1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A SYNJ2 TOR1B SYT9 SYT8 SNAP91 DAB2 COPS4 IL7R PICALM COPS2 STON2 CD4 PIK3C2A DNM1 SLC2A8 DNM3 SGIP1 EPS15L1 ARFGAP1 EPN1 EPN2 GAK CTTN ARF6 LRP2 FCHO1 FCHO2 REPS2 UBQLN1 UBQLN2 HIP1R APOB NECAP2 NECAP1 SYT11 TRIP10 SYNJ1 ARRB1 ARRB2 EGFR AGTR1 SYT2 FNBP1L SYT1 EGF FNBP1 UBA52 CFTR EREG AREG BTC VAMP2 EPGN HBEGF TFRC SLC18A3 CLTB AVPR2 AVP RPS27A UBB;UBC HSPA8 M6PR DNM2 VAMP8 VAMP7 DNAJC6 TACR1 WNT5A TF COPS7B COPS7A COPS3 COPS6 COPS8 TGOLN2 OCRL RAB5B RAB5C RAB5A ITSN1 CHRM2 IGF2R FZD4 VAMP4 ADRB2 CD3G CD3D VAMP3 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate TSTD1 SQOR SUOX TST ETHE1 SLC25A10 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones NCOR1 H2BC21 SAP30 TBL1XR1 BRMS1 PHF21A SAP30L SAP18 SUDS3 MBD3 RCOR1 H2AC14 GATAD2B GATAD2A HDAC2 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HDAC8 H2BC5 H2AC16;H2AC11 RBBP7 HDAC1 H2BC1 CHD4 CHD3 HDAC3 MTA1 H2BC15;H2BC3;H2BC11;H2BC12 MTA3 HDAC10 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 MTA2 NCOR2 REST H2AC20 GPS2 ARID4A ARID4B H2BC18 KDM1A HMG20B MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle SLC25A13 GOT1-1 GOT2-1 SLC25A18 MDH1 MDH2 SLC25A12 SLC25A22 SLC25A11 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction MPP5 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine GLYATL3 GLYAT ACSM1 ACSM2A;ACSM2B FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription SIRT1 SIN3A HDAC2 FOXG1 YWHAZ FASLG AGRP SOD2 FOXO3 BTG1 HDAC1 PCK1 BCL2L11 POMC KLF4 MSTN CAV1 CDKN1A SREBF1 CDKN1B KAT2B FOXO1-1 GADD45A CITED2 INS;INS-IGF2 NFYB GCK NFYC YWHAB CCNG2 FOXO4 ATXN3 NPY NFYA-1 NR3C1 YWHAG DDIT3 TXNIP FBXO32 G6PC1 SMAD2;SMAD3 SMAD4 AKT2 SFN AKT3 IGFBP1 AKT1 ABCA6 TXN YWHAQ TRIM63 CAT PCBP4 BBC3 RBL2 RETN PLXNA4 EP300 PPARGC1A SIRT3 STK11 CREBBP PINK1 BCL6 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint GTSE1 FKBPL HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 HSP90AB1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PLK1 PSMA1 UBA52 PSMD12 PSMD11 CCNB2 PSMD14 CCNB1 PSMD13 PSMA7 CDK1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 MAPRE1-1 PSMB1 CDKN1A RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 TP53 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP4B CHMP3 CHMP4A BECN1 MAP1LC3B2;MAP1LC3B-1 CHMP6 UVRAG CHMP7 ISCU PIK3R4 CHMP2B CHMP2A PIK3C3 CHMP4C DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly ITGB3BP CENPA H2BC21 CENPC HJURP RSF1 H2AZ2;H2AZ1 MIS18BP1 OIP5 CENPW KNL1 H2AJ CENPT CENPX MIS18A NPM1-2 CENPU H2AC14 CENPH CENPN-2 CENPS-CORT;CORT;CENPS CENPI RBBP4 SMARCA5 CENPK CENPL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPM H2BC5 CENPO RBBP7 CENPP CENPQ H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 RUVBL1 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release CANX CALR-1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ AR KDM4C-1 KLK3;KLK2 H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOA2 H2BC5 KDM1A PKN1 H2BC1 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L NCBP2-1 GTF2F1 GTF2F2 FGF1 POLR2J;POLR2J2;POLR2J3 FGF2 FGF3 FGF4 FGFR2 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 NCBP1 POLR2A POLR2B POLR2C POLR2D PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import USP9X PECR ZFAND6 IDE CROT PEX26 SCP2 NUDT19 MPV17 GSTK1 ECH1 LONP2 PIPOX UBA52 UBE2D1 PEX1 BAAT PEX7 ACOX2 ACOX1 PEX6 UBE2D3-1 AGPS ACOX3 AGXT PAOX PHYH-4 DDO HAO1 HACL1 ACOT2;ACOT1 NOS2 EPHX2 RPS27A TYSND1 UBB;UBC DHRS4 NUDT7 AMACR DAO CRAT IDH1 PEX10 PEX2 PEX12 PEX13 PEX14 ACOT8 HMGCL EHHADH-1 ACAA1-1 HSD17B4 DECR2 SLC27A2 ACOT4 CAT GNPAT UBE2D3;UBE2D2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling SOCS3 JAK2 MAPK1 PRL MAPK3 PTPN6 LYN IRS1 ADAM17 IRS2 STAT5A CISH STAT5B PRLR GHR SOCS2 PTPN1 SOCS1 STAT1 STAT3 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses GJD2 GJC1 PANX1 PANX2 GJA10 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease HDAC2 H2AC16;H2AC11 TLR8 TLR7 TLR3 TXNRD1 PML C1S SH3GL3 SH3KBP1 SRC MBL2-1 CTNND1 MASP1 STAM CBL CDH1 HGS CTNNB1 CGAS STAM2 MET EPS15 IRF7 CBLL1 SH3GL2 SH3GL1 DHX9 YWHAB PRMT1 XRCC6 XRCC5 MAP2K2;MAP2K1 STING1 MAPK1 MAPK3 MAPK14 NPM1-2 SMAD4 SOS1 CRK YBX1 HDAC3 CTSV;CTSL LY96 HBD;HBB XPO1 EP300 HMOX1 MED1 CREBBP APOA1 JAK2 HBA2;HBA1 NCOR1 TBL1XR1 TLR4 NFE2L2 PPIA CALM3;CALM1 FKBP1A YWHAE JUN RBX1 GNGT1 ATP6V1H WNT5A GNAS-1 ZBP1 TBK1 IRF3 GNG10 GNG2 GNG5 FIP1L1 GNG4 GNG8 FZD7 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 HDLBP CUL3 AP2A1 AP2A2 LIG4 XRCC4 AP2M1 RB1 PRKACB-1 AP2S1 DAXX ARID4A AP2B1 ARID4B FNTA BLNK HMG20B JAK3 P4HB IL1R1 IFNGR1 IFNGR2 SIGMAR1 NUP107 TYK2 SAP30 BRMS1 IFNAR1 ENO1 PHF21A CD79B PPP1CC CD79A SAP30L S1PR1 SAP18 SUDS3 CRBN STAT2 DYNC1LI1 RCOR1 FNTB;CHURC1-FNTB CPSF2-1 DYNC1LI2 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T HSPG2 WDR33 NUDT21 CLP1 PCF11 NUP160 PAPOLA SDC4 SYMPK SDC2 SDC3 NUP85 RPS27 SDC1 SEC13 NUP133 RANGAP1 DYNC1I2 NUP43 DYNC1I1 RANBP2 DYNC1H1 GPC1 TAOK1 GPC3 GPC2 GPC5 GPC4 GPC6 NUP37 AGRN TJP1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT TKFC POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L RNGTT LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 H2AC14 AKT2 AKT3 AKT1 PROS1 CLDN1 CSNK2A2 CD33-1 CSNK2B MRC1 EMC4 HSPA5 TIMD4 RPN2 MERTK MAPKAP1 AXL TYRO3 RPN1 MAPRE3 GAS6 LY6E PIK3R1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN YES1 H2AC20 CD28 EZH2 CD3G MAGT1 RAC1 JAK1 VAV1 CSNK2A1;CSNK2A3 RICTOR TRAF3 CD14 PAK2 IKBKE BRD4 SUZ12 H2BC5 STAT1 H2BC1 VCP-1 HNRNPU TUSC3 MTA1 ANO8 MTA3 NEK2 ANO9 ANO6 H2AC4 ANO4 ANO5 TMEM258 ANO2 ANO3 ANO1 OST4 NFKB2 OSTC STT3A ANO10 STT3B GSK3A PARP6 PRR5 PARP4 GSK3B GALNT1 PARP16 PARP9 PARP14 PARP8 H2BC21 PARP10 MLST8 PRKG2 YWHAG EED PDPK1 DDOST DAD1 LCK CDC42 PRKAR1A RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN RBBP7 PTPN11 MTOR CD4 H2BC15;H2BC3;H2BC11;H2BC12 TSG101 PTPN6 VPS4B PDCD1 VPS4A MVB12B CCNK MVB12A CCNT1 VPS36 VTA1 ELL VPS37C GTF2B VPS37D ELOC-1 VPS37A TAF7L SNF8 ELOA VPS37B ELOB NELFB UBAP1 NMT2 NELFA VPS25 NELFCD VPS28 NELFE CHMP5 SUPT16H TBP NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GJA1 RCC1 NMT1 TUFM CCR5 RANBP1 TUBB4A;TUBB;TUBB8B;TUBB8 CSNK1A1 ACTB-1 DDX58 NUP205 IFIH1 NUP188 RNF135 PSIP1 SIKE1 AAAS CLEC4M;CD209-2 MAVS TRIM25 NUP42 NUP62 SRPK2 TPR SRPK1 BANF1 CX3CR1 ITGB1 NUP88 RAB5B RAE1 CYFIP1 RAB5C KPNA1 IGF1R NDC1 NCL-1 NUP214 RAB5A NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 RPL4 ELMO2 RPL30 DOCK2 RPL3 DOCK1 CALR-1 RPL32 HSPA1A;HSPA1B RPL31 RAB7A RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 KPNA7 RPL35 RPL38 KPNA5 KPNA2 RPS11 KPNA3 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 PPP1CB RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 PPP1CA RPL26 RPL29 RPL28 KPNB1 RPL10;RPL10L-1 KPNA4-1 CPSF4 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 CLTC PTK2 CLTA RPS4X RPL7A GBP2;GBP3;GBP1 RPLP2 RPL36-1 HSP90AA1 PARP1 RPS3A DNAJC3-1 CANX RPL13A-1 RPL11 PRKAR2A RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 NRP1 RPL35A RPL23A PABPN1-1 RPL22L1 NCK1 FAU RAN RPL26L1 CXCR4 RUNX1 MYO9B FASN DPM1 DPM2 U2AF1L5;U2AF1 DPM3 EIF4A3 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 TMPRSS2 ACE2 DHX38 SRSF11 ELK1 SRSF4-1 ALYREF HBEGF RNPS1 ARF1 HSPA8 F2 COMT PIK3R4 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 B2M TLR9 PIK3C3 AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL6R KEAP1 UBE2L6 HERC5 TRAF6 UBE2V1 UBE2D3;UBE2D2 UBE2N TAB3 TAB2 TAB1 YWHAH ATG7 YWHAZ HDAC1 CAV1 ELAVL1 VAV3 C4BPA C4BPB CLU VAV2 IMPDH1 IMPDH2 HSP90AB1 ROCK1 ROCK2 CUL5 UBA7 UBA6 UBA5 UBR4 ACTG1 CPSF7 HNRNPC VIM RBMX UBA3 UBA1 FURIN H2BC18 RPTOR BECN1 RNF213-2 MAP1LC3B2;MAP1LC3B-1 UVRAG ISCU PGK1 EIF4E EIF4G1 SNAP25 SV2C SYT2 SV2B VHL SYT1 SV2A VAMP1 STX1A VAMP2 ACOT2;ACOT1 SEC23A NOS2 SAR1B SCAP GBP6 GRPEL1 SEC24B HYOU1 SEC24A MED19 MED18 PQBP1 MED11 SEC24D-1 MED29 MED22 MED21 SP1 ATL2 SRRT VPS33A VPS33B SEC24C PATJ ZCRB1 MPP5 CRB3 SNRNP200 CORO1A G3BP1 G3BP2 FUS NACA BCAS2 NCKAP1 CTNNBL1 WASF1-1 PRCC HNRNPA0 HNRNPA3 GPKOW CASP1 CDC5L KDELR1 CCAR1 CD2BP2 PCBP1 PCBP2 PDCD6IP RIPK3 RBM10 MED13L IL18 BST2 RETREG1 IL1A SUGP1 IL1B DHX15 UFD1 CYBA CHMP4C DHX16 ARIH1 CHMP4B SFTPD NOXO1 CHMP3 BCAP31 CHMP4A PEX19 NLRP12 CHMP6 HNRNPA2B1 CHMP7 IL17F IL17A WBP11 HNRNPUL1 NCKAP1L DNAJB11 WASF2 PPIE BAIAP2 PPIH PPIG RIPK1 PPIB ABI2 RTN3 DDX46 ABI1 NOXA1 DDX42 SUN2 GSDMD NOX1 CASP5;CASP4 RBM17 ITCH DYNLT1 BUD31 CHMP2B MMP9 CHMP2A RBM22 DDX23 RRBP1 GBP7;GBP4 SMNDC1 CNBP-1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM NPLOC4 HNRNPK HNRNPF HCK CD8B;CD8B2 HNRNPD CLINT1 ELMO1 HNRNPA1-1 SF3B4 SF3B5 MED28-1 SF3B2 SF3B3 ISY1;ISY1-RAB43 SF3B6 SF3B1 SF3A3 DDX3X-1 SF3A1 UPK1A EPCAM SF3A2 XAB2 PHF5A AUP1 IPO7 CYFIP2 CLEC5A WIPF1 TXNL4A WIPF2 SNRPN WIPF3 BAG2 PYCARD CHERP AHCYL1 CYSLTR1 P4HA1 CYSLTR2 P4HA2 GNAT3 P4HA3 C3AR1 RCAN3 GGT1 EIF4G3 ENTPD1 EIF4G2 ENTPD5 EIF4E3 ADCY9 DUSP16 PRKACA-1 PRKAR1B PTBP1 BTK SFPQ-1 DPEP2 PLRG1 DPEP1 LARP1-1 ATP1B2 GNAZ SNRPA1 ATP1B1 MEFV DNAJC8 NCKIPSD CEBPD PUF60 FCGR3A;FCGR3B PRKAR2B SNRPB2 DVL1 SEC11A PLCG2 SEC11C CAMK2B DVL2 SNRNP40 CAMK2D DVL3 VPS41 CAMK2A DNAJA2 NLRP3 ATP1A4 GGT5 ITPR1 VPS45 MYO5A ITPR2 PPIL3 ARPC4 PPIL4 ATP1A3 ARPC5 PPIL6 ATP1A2 ARPC2 ITPR3 SRRM2 ARPC3 AQR ACTR3-1 CRNKL1 ATP1A1 ARPC1B NMI ARPC1A PRPF19 CAMK2G WASL CHMP1A PSTPIP1 TOMM70 CTSG ATP1B3-1 IL17RC ACTR2 IL17RA SYK TLR1 FXYD2;FXYD6-FXYD2 HNRNPH1 FGR ADORA2B HNRNPH2 ADCY4 TLR6 GNAI3 TLR2 FXYD4 WAS SPCS3 FXYD3 ADCY3 SPCS2 PRKX SPCS1 FXYD1 ADCY2 CWC25 FXYD6 ADCY1 PPIL1-1 ADCY8 CWC27 ADCY7 EFTUD2 GNAI1 CWC22 ADCY6 PDIA3 GNAI2 PRPF6 ADCY5 PRPF8 NT5E PDZD3 FCGR1A CBX1 MAP2K4 WASF3 CWC15 MYO10 DNAJC10 P2RX7 ELAVL2 P2RX4 RBM5 MYO1C LTF SUGT1 TRIM27 TXN MAP2K7 LIG1 IL6 MAPK8 IFNB1-4 CD9 PLCG1 BCL2L1 EEF1A1 EEF2 ADAM17 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SMN2;SMN1 GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX20 SNRPE-2 SNRPG-2 C3-1 LOC110384692;C4A;C4B_2;C4B GUCY2C RIPK2 NOD1 NOD2 IRAK2 ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS GOLGA7-1 MGAT4C ZDHHC9 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 IL10 CD163 PLK2 RHBDF2 MYH9 TXNIP CCNC-1 SFN MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 MED23 MED25 MED24 MED20 EGFR MBD3 GATAD2B GATAD2A EXOC1 GBF1 MED30 ITGA4 COG1 TRIM28 SNW1 XRN1 KDM1A FKBP4 MED31-1 DDX5 PTGES3-1 IRAK1 SMAD2;SMAD3 CHD4 CHD3 YWHAQ MTA2 REST MED8 MED4 MED6 MED7 NEDD4L PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A NCOR2 UBB;UBC ADRM1 NFKB1 TAL1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 GPS2 PSMC1 NFKBIB UBE2I NR3C1 SUMO1 NRBP1 FEN1 ABL1 EIF4A2 EIF4A1 CDK8 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 AGRN EXT1 EXT2 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 GPC5 SDC2 GPC4 SDC3 GPC6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling CBFB RUNX1 LIFR IL3 ELF1 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX5 ALOX12 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules SULT1C2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 TPST2 BPNT2-1 PODXL2 TPST1 ABHD14B BPNT1 SULT6B1 SULT2A1-4 SULT4A1 SULT1B1-1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex SSRP1 CDK9 NCBP2-1 CCNT2-1 TCEA1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 CCNK CCNT1 ELL AFF4 ELOC-1 MLLT1 MLLT3 ELOA SUPT6H ELOB IWS1 NELFB EAF1 NELFA EAF2 NELFCD NELFE SUPT16H NCBP1 CTDP1 SUPT4H1-1 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes KCNU1 CATSPER1 CATSPERB CATSPER3 CATSPERD CATSPER2 CATSPERG CATSPER4 HVCN1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle TRAK1 RAP1GDS1 MFN1 MFN2 MYO19 TRAK2 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility RAC1 HGF LAMA5 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 LAMA4 LAMA3 LAMB1 LAMC2 GAB1 RAPGEF1 LAMC1 CRK ITGB1 ITGA3 ITGA2 SRC MET DOCK7 TNS4 TNS3 CRKL RAP1B RAP1A PTK2 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation RPA1 TRIM28 TP53BP1 HNRNPK SIN3A RNF168-1 RAD52 MITF L3MBTL2 XRCC4 HDAC2 IKBKE SUZ12 HDAC1 HDAC7 MTA1 PML TOPORS EIF2AK2 SATB2 NFKB2 DAXX MDC1 DDX5 ZNF350;ZNF432 NUP107 SMC3 PARP1 FOXL2 HIC1 SP3 NPM1-2 CBX5 TFAP2C CDCA8 NUP160 TDG MDM2-2 NUP85 TRIM27 RAD21 CHD3 CETN2 CBX8 HNRNPC STAG1 PHC2 STAG2 PHC1 AURKA CBX4 CBX2 PHC3 SEC13 NRIP1 EP300 NUP133 PPARGC1A BMI1 NCOA1 RANGAP1 SMC1A SMC5 NCOA2 SMC6 RING1 DDX17 CREBBP INCENP NSMCE3 BIRC5 NSMCE2 NSMCE1 MRTFA EID3 ZBED1 RNF2 UBA2 SAE1 AURKB TOP2A TOP2B ZNF131 NUP43 SENP5 SENP2 SAFB SENP1 NSMCE4A TOP1 CDKN2A IKBKG SP100 RANBP2 UHRF2 SATB1 CASP8AP2 NOP58 RWDD3 MBD1 PARK7 VHL NUP37 RELA ING2 NCOR2 TP53 NFKBIA PIAS4 HDAC4 PIAS3 UBE2I PCGF2 THRB VDR NR1H2 RORA NR3C1 HIPK2 ESR1 NR2C1 NR3C2 PIAS1 CTBP1 NR4A2 NR5A1 AR XPC RXRA SUMO1 SUMO3 SUMO2 RARA PPARG PGR NUP205 PPARA NUP188 AAAS TFAP2E;TFAP2B BRCA1 NUP42 NUP62 TPR NUP88 RAE1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 BLM DNMT3B DNMT3A PCNA DNMT1 HERC2 WRN DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 PTPN11 HRAS PIK3R1 FRS2 PIK3CA FGF1 FGF2 FGF4 GAB1 FGF9 SOS1 FRS3 FGF20 FGF23 FGF16 PLCG1 FGF18 NRAS INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling PTPN11 PTPN2 IL18R1 PTPN6 PTPN4 PTPN12 TBK1 CASP1 SMAD2;SMAD3 PTPN18 IL37 PTPN20 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR STAT3 PTPN9 PTPN7 PTPN5 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMKK2 CAMK4 CALM3;CALM1 KPNA2 CAMK2G CAMK2B CAMKK1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 CD14 MAP3K8 BTK NFKB2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 PPP2R1B MAPK14 PPP2R1A TLR6 TLR2 MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 SOCS1 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C FGB FGA MAPK9 MAPK8 FGG TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 SIGIRR CUL1 S100A1 CD36 RELA IRAK3 TIRAP RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB S100A9 S100A8 CASP8 RPS6KA5 TRAF2 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease WDR61 DIS3 EXOSC7 HBS1L EXOSC6 TTC37 EXOSC5 NT5C3B EXOSC4 EXOSC9 DCPS EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIV2L PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines WDR5 EED SMYD2-1 SETD1B SETD1A NSD2 EHMT2 EHMT1 RBBP4 RBBP5 SUZ12 RBBP7 RELA PRDM16 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SUV39H2 KMT5A SETD2 SETD3 KMT2A SETD6 KMT2C SUV39H1 DOT1L SETD7 NFKB1 NSD3 MECOM NSD1 KMT5B SMYD3 NFKB2 ATF7IP EZH2 SETDB1 KMT5C KMT2D ASH1L AEBP2 ASH2L PRDM7;PRDM9 KMT2B DPY30 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine GOT2-1 GADL1 CSAD ADO TXN2 MPST TSTD1 SQOR FMO1 SUOX TST ETHE1 CTH SLC25A10 CDO1 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway ENOPH1 GOT1-1 MTAP ADI1 APIP MRI1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress AMER1 PALB2 NPLOC4 SIN3A CUL3 CSNK2A1;CSNK2A3 PRKCD STAT3 VCP-1 TXNRD1 ATP7A COX7B FABP1 COX7C COX8A CDKN1A COX8C COX5B COX5A SKP2 NOX4 COX6C NLRP3 ALB GSK3B COX7A2L-1 P4HB IDH1 GSTA3;GSTA1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 TXNIP COX7A2 PRKAA2 TALDO1 EIF2AK3 TXN SMARCD3 HDAC3 CHD9 CAT HBD;HBB BACH1 HELZ2 TGS1 EP300 HMOX1 NCOA1 MED1 NCOA2 CREBBP NCOA6 HBA2;HBA1 NCOR1 TBL1XR1 MAP1LC3B2;MAP1LC3B-1 CARM1 MAFK PSMD8 NFE2L2 PSMD6 PSMD7 PSMD2 TKT PSMD3 PSMD1 CDKN2A BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF SOD2 UBA52 BCL2 PDGFA PSMD12 AREG PSMD11 BCL2L1 PSMD14 PSMD13 PRDX2 CUL1 SQSTM1 RELA PSMA7 PRDX1 PSMB6 SESN2 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 NCOR2 RPS27A PGD UBB;UBC TXN2 ADRM1 NOTCH1 NFKB1 RBX1 PSMA2-1 SEM1 PSMC5 ABCG2 PSMC6 PSMC3 PSMC4 PSMC1 ERO1A AQP8 NUDT2 SESN1 MUL1 ATF4 HMOX2 SP1 CCL13;CCL2 ABCF2-H2BE1;ABCF2 DPP3 PRDX3 STAP2 PRDX6 GCLC MAFG NOX5 GCLM SRXN1 CHD6 ME1 NCF1 UBXN7 RXRA NCF2 ABCC3 GPX1 NCF4 GPX6 GPX5 GPX8 GPX7 AKT2 BLVRB PPARA MYC BLVRA AKT3 HM13 AKT1 BRCA1 GSTP1 NQO1 CSNK2A2 COX4I1 TXNRD2 COX4I2 SOD3 CYBB CSNK2B ATOX1 SOD1 CYBA UFD1 CCS PTK6 ABCC1 FBXL17 CYCS-1 PRKCI KEAP1 SLC7A11 NDUFA4 TRIM21 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein MOGS GANAB CANX MGAT1 PRKCSH PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 PTPN11 PIK3R1 FRS2 PIK3CA FGF1 FGF2 FGF3 FGF4 FGF6 GAB1 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN RIT2 NTRK1 BRAF NGF RIT1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis MAPK14 MAPK12 MAPK11 CDON CDC42 NTN3 CDH4 BNIP2 CTNNA2 NEO1 SPAG9 MAP2K6 MYOG MEF2B;BORCS8-MEF2B MYOD1 MYF6 CTNNA1 TCF4 CDH15 MYF5 ABL1 TCF12 CTNNB1 MEF2D CDH2 MEF2C MEF2A CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation MAPKAPK2 ATF1 RPS6KA3 RPS6KA2 RPS6KA1 RPS6KA5 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages PRL LAMA5 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 LAMA4 FGF2 LAMA3 FN1 FGF4 LAMB1 LAMC2 FGF7 LAMC1 VTN TGFA EGF AREG FGF10 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 CTLA4 IL2RA SMARCB1 LGALS3 SIN3B SIN3A H2AJ SMARCC1 SMARCC2 CSNK2A1;CSNK2A3 AGO3;AGO1 SMARCD1 SMARCD2 H2BC5 HDAC1 H2BC1 SMARCA2 SMARCA4 SMARCE1 TP73 PML H2AC4 CTSK SRC KMT2A KMT2C PBRM1 CCND3 ZFPM1 CCND2 CCND1 CDK6 PRMT6 PRMT1 SPI1 GP1BA DPY30 H2BC21 WDR5 LMO1 ARID2 LMO2 CLDN5 H2AZ2;H2AZ1 LIFR KCTD6 GATA3 GATA2 GATA1 RBBP5 AUTS2 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 IL2 IL3 NR4A3 BLK LDB1 ELF1 TNRC6A-1 ELF2 PTPN11 CBFB PAX5 SMARCD3 TNRC6C RUNX1 CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 CBX8 CBX6 ARID1A TNRC6B PHC2 ARID1B PHC1 CBX4 IFNG CBX2 THBS1 PHC3 EP300 MYB ACTL6B BMI1 ACTL6A RING1 CREBBP RNF2 SERPINB13 PSMD8 PSMD6 PSMD7 NFE2 PSMD2 PSMD3 PSMD1 SETD1B SETD1A NFATC2 CR1L;CR1 PRKCB PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 RSPO3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TCF12 PSMB1 RPS27A KAT2B UBB;UBC ADRM1 TAL1 PSMA2-1 TJP1 SEM1 OCLN-1 FOXP3 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 KMT2D CCNH KMT2B GPAM SOCS3 PCGF5 HIPK2 ESR1 RYBP SOCS4 CSF2 ITGA2B CDK7 MNAT1 H2AC14 PF4;PF4V1-1 CSNK2A2 CSNK2B YAF2 TNFRSF18 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ABL1 MOV10 AGO4 H2AC20 AGO2 ITCH H2AB2;H2AB3;H2AB1 PRKCQ ASH2L CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization CLDN11 RAC1 CLDN10 CLDN15 CLDN14 JAK1 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 FARP2 WT1 MPHOSPH8 H2AJ PVR CDH9 HACE1 CSNK2A1;CSNK2A3 CDH7 AGO3;AGO1 FOXQ1 PRKCSH CDH6 CDH5 CDH3 TLE1 ZBTB33 SOX10 IL6ST SDK1 HDAC2 GANAB SDK2 CLDN22;CLDN24-1 PKM SUZ12 CDH10 H2BC5 CDH12 CDH13 STAT3 CDH17 CDH18 HDAC1 H2BC1 CDH19 CTSS PARD6G PARD6B MOGS MCRIP1 CTSB NECTIN4 NECTIN3 KLF4 NECTIN2 NECTIN1 H2AC4 MYCN SNAI2 TMEM258 SRC CTNND1 TWIST2 CDH1 CTNNB1 BANP OST4 EPS15 CBLL1 RNF19B OSTC STT3A MAPK1 VAV2 H2BC21 MAPK3 EED CLDN5 H2AZ2;H2AZ1 DDOST DAD1 CDC42 RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TNRC6A-1 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 ARID1A TNRC6B FURIN PCSK6 CDH2 ZEB1 TRAF7 JAK2 SIRT1 VCL KMT5A JUP SP1 PATJ MPP5 CRB3 ARHGEF4 CTBP2 CTBP1 F11R PARD6A PARD3 BIRC2 XIAP DOCK1 HEYL ELMO1 ARHGAP32 SMARCA4 ANGPTL4 PRDM8 BHLHE22 CDH8 CTNNA1 CDH24 RB1 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 SNAI1 SEC11A SEC11C KDM1A TYK2 CANX POMT2 SPCS3 SPCS2 ZNF217 SPCS1 POMT1 TFAP2A MDM2-2 ANG ANK3 TGIF2 IL6 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 TIAM1 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ZEB2 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 PSMC5 PSMC6 DNM2 PSMC3 PSMC4 PSMC1 H2AC14 MYC CLDN1 CSNK2A2 CSNK2B RPN2 CDH4 RPN1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDH15 FOXA2 PRKCI IL6R CLDN2 MTBP MOV10 ZC3H12A AGO4 CLDN6 H2AC20 CLDN4 AGO2 CLDN3 CLDN9 H2AB2;H2AB3;H2AB1 CLDN8 EZH2 CLDN7 CADM3 CADM1 CADM2 CLDN23-1 PCSK7 CLDN20 ZMYM2 RACK1 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex TAB2 TAB1 TLR4 LY96 IRAK2 RPS27A UBB;UBC MAP3K7 TICAM2 TICAM1 TRAF6 CD14 UBA52 TAB3 INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling JAK1 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 USP18;USP41 PRKCD UBE2E1 STAT1 STAT3 CDK1 PML IFIT5 IFI35 IFI30 IFIT1 IFIT3 IFIT2 NEDD4 ICAM1 TRIM29 TRIM26 FAAP100 RSAD2 PDE12 TRIM14 TRIM10 ATF6 EGR1 IRF7 MX1-1 TRIM8 DHX9 TRIM6 HLA-DRA TRIM5 TRIM2 TRIM3 RNASEL FAAP24 LOC105377022;FANCB PGGT1B FLNB MAPK1 HSPA1L IFI44L ILF2 MAPK3 MID1 IFITM3;IFITM2;IFITM1 GBP5-1 IP6K2 VCAM1 FANCM FANCL FANCA HSPA2 FANCE IRF1 FANCG NPM1-2 FANCF UBA7 ISG20 CIITA PPM1B HLA-DQB2;HLA-DQB1 ADAR OASL SFN TRIM68 EIF2AK3 ACTG1 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 OAS1 SMAD7 OAS3 IRF8 SOCS1 IRF6 EIF4E2 IRF9 SAMHD1 TRIM46 YBX1 SNCA PTPN11 TRIM45 TRIM35 TRIM38 TRIM31 PTPN6 IFNG FURIN JAK2 BECN1 RAF1 EIF4E CENPX EIF4G1 MT2A SPHK1 TP53 GBP6 SOCS3 ACTB-1 IRF3 CASP1 DDX58 NUP205 IFIH1 PIN1 NUP188 AAAS MAVS TRIM25 NUP42 BST2 NUP62 TPR NUP88 IRF2 RAE1 KPNA1 ARIH1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 GBP7;GBP4 PTPN1 HSPA1A;HSPA1B KPNA7 DUS2 KPNA5 KPNA2 KPNA3 FLNA KPNB1 EIF4G3 EIF4G2 KPNA4-1 EIF4E3 EIF2AK2 ILF3 ISG15 PIM1 CAMK2B CAMK2D CAMK2A FNTA IFNGR1 IFNGR2 NUP107 TYK2 GBP2;GBP3;GBP1 CAMK2G IFNAR1 DNAJC3-1 PPP2R1B PPP2R1A STAT2 FNTB;CHURC1-FNTB CENPS-CORT;CORT;CENPS NCK1 FCGR1A NUP160 NUP85 MAP2K6 PPP2CB;PPP2CA SEC13 NUP133 PPP2R5A NCAM1 EIF4A3 NUP43 IKBKB IFNB1-4 IKBKG SP100 RANBP2 CD44 CHUK PLCG1 UBA52 PTPN2 NUP37 PRKRA RPS27A UBB;UBC TARBP2 HSPA8 PTAFR ABCE1 UBE2I PIAS1 SUMO1 IRF5 B2M HSPA5 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EIF2S2 EIF2S3;EIF2S3B FKBP5 EIF2S1 PSMB8 EIF4A2 EIF4A1 UBE2L6 HERC5 HLA-DPB1-1 FANCC IRF4 TRIM21 UBE2N MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase LBR ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SPAST CC2D1B VPS4A SIRT2 IST1 VRK1 LEMD2 ESPL1 XPO1 TNPO1 PTTG1;PTTG2 TUBA1C TUBA1A TUBB1 LMNB1 RCC1 TUBB2B;TUBB2A TUBA4A TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 NUP205 NUP188 NUP62 BANF1 CHMP4C NDC1 CHMP4B ANKLE2 CHMP3 CHMP4A NUP155 CHMP6 NUP93 CHMP7 POM121;POM121C NUP35 NUP54 EMD LEMD3 CHMP2B CHMP2A KPNB1 FBXO5 PPP2R2A;PPP2R2D ERCC6L NUP107 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 RAN SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC PSMD8 NUP43 BUB3 PSMD6 BUB1 PSMD7 DYNC1I1 PSMD2 CLASP1 PSMD3 CLASP2 PSMD1 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMC2-1 CENPI PSMA5 TAOK1 PSMA6 CENPK PSMA3 CENPL PSMA4 CENPM PSMA1 B9D2 UBA52 CENPO CENPP CENPQ PSMD12 SPC24 PSMD11 SPC25 PSMD14 MAD2L1 PSMD13 NUP37 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UBE2I SUMO1 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs TSC2 RAB11B TSC1 TBC1D2 RABEP1 TBC1D7;TBC1D7-LOC100130357 MAP1LC3B2;MAP1LC3B-1 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B TBC1D20 OPTN-1 RAB5B RAB5C RAB6A RAB5A RAB6B RAB11A RABGAP1 GABARAP ARF6 GGA2 GGA1 RABGEF1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8A TBC1D10B RAB8B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B-1 RAB7A ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PNPLA8 PLA2G1B MBOAT2 LPCAT1 PLAAT3 PLA2G5 LPCAT3 LPCAT2 PLBD1 PLA2G2A-1 PLA2G4A JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLA2G12A PLA2G2E PLA2G4D LPCAT4 PLA2R1 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism ENO1 PGK1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity MAPK1 CASP9 MAPK3 AVEN APAF1 DIABLO-1 UACA XIAP CYCS-1 APIP FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling CASP8 FADD FAS FASLG CASP10 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation POLR2E POU2F1 POLR3E POLR2F POLR1C POLR3F POLR2H POLR1D POLR3G POLR2L POLR3H BDP1 POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 GTF3C2 GTF3C3 CRCP TBP GTF3C4 GTF3C5 BRF1 POLR3GL GTF3A GTF3C6-1 POLR3A POLR3B POLR3C POLR3D IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade FLT3 PIK3CB HRAS PDPK1 FRS2 KLB IRS1 PDE3B PIK3CA PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 GAB1 FGF9 SOS1 AKT2 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 IRS4 IGF1R FGF10 IGF2 PTPN11 FLT3LG IGF1 PIK3R2 PIK3R1 THEM4 NRAS ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) TUT7 TUT4 LEUTX DPPA4 DPPA2 TEAD4 TPRX1;RAX2 ZSCAN4 DUX4;DUXA DUXB EP300 TP53 YAP1-1 CREBBP HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors HRH1 HRH3 HRH2 HRH4 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 FGFR3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL2 OS9 ERLEC1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 SYVN1 RPS27A UBB;UBC ADRM1 SEL1L PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SHH DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B PABPC1;PABPC3 EIF4G1 CNOT10 CNOT11 TUT7 TUT4 PARN TNKS1BP1 PAIP1 PAN2 PAN3 EIF4A2 EIF4A1 CNOT6L CNOT4 CNOT6 EIF4A3 CNOT7 CNOT1 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors CD5L SSC5D CD36 PRDX1 APOB S100A9 SAA2;SAA1 HMGB1-1 APOA1 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 HDAC1 CCNB1 CDK1 RB1 CDKN1C CDKN1A CDKN1B CCND3 CCND2 CCND1 FBXO5 E2F1 E2F2 E2F3 SKP2 TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 PPP2R2A;PPP2R2D PPP2R1B PPP2R1A RBBP4 MYBL2 RBL2 RBL1 PPP2CB;PPP2CA CDC45 MCM7 MCM3 MCM4 MCM5 MCM6 MCM2 CCNA2-1 CCNA1 JAK2 E2F4-1 TOP2A PSMD8 PSMD6 CDKN2D PSMD7 CDKN2B PSMD2 PSMD3 CDKN2C PSMD1 CDKN2A SKP1 CDC7 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 DYRK1A SEM1 TK1 DHFR2;DHFR RRM2-1 PSMC5 TYMS PSMC6 PPP2R3B PSMC3 PSMC4 PSMC1 CCNH MAX CDC6 CDK7 MNAT1 AKT2 MYC AKT3 AKT1 POLE GMNN PTK6 LIN54 CKS1B LIN52 CDT1 LIN37 LYN LIN9 MCM10 CABLES1 ABL1 WEE1 ORC5 ORC4 DBF4 ORC6 ORC1 MCM8 ORC3 ORC2 E2F5 E2F6 PCNA PRIM2 PRIM1 POLA1 POLA2 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux NCOR1 TBL1XR1 NR1H2 RXRA AGO3;AGO1 APOE KDM4A TNRC6A-1 TNRC6C HDAC3 ABCG1 CETP TNRC6B NCOR2 MOV10 AGO4 EP300 AGO2 ABCA1 RXRB APOC4 KDM3A GPS2 KDM1B NCOA1 NR1H3 APOD ABCG8 ABCG5 ARL4C EEPD1 APOC2 KDM1A APOC1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding MC4R EDNRB EDN1 EDN3 MC3R POMC MC1R MC5R CGA C5AR2 TSHB C5AR1 NPY OPRM1 OPRK1 RXFP4 RLN3 RLN2;RLN1 INSL3 RXFP1 INSL5 APP RXFP2 RXFP3 GLP1R VIPR1 WNT2B VIPR2 SCT IHH ADM FZD10 PTH1R ADGRE1 GNGT1 CRHBP ADRA1D SHH ADRA1B UCN3 ADRA1A ADGRE5 ADGRE3 GLP2R WNT5A WNT9B PTH2R WNT9A WNT16 GNAS-1 GIP ADCYAP1 SMO CRH IAPP CALCA ADCYAP1R1 TBXA2R RAMP2 CALCRL RAMP3 GIPR PTH DHH WNT8A WNT8B CRHR1 PTHLH GHRHR WNT6 GNG10 WNT11 CALCR GNG2 GNG5 GNG4 GNG8 WNT1 WNT2 CD55 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 CHRM2 FZD4 CHRM3 CHRM1 WNT3A CHRM4 PTCH1 CHRM5 CALCB;CALCA HTR2B GCGR WNT7B ADRB1 FZD7 ADRB2 FZD6 HTR2A HTR4 PTCH2 SCTR HRH1 HTR6 FZD9 HTR7 FZD8 WNT7A HRH3 GCG HRH2 GNG13 HRH4 DRD1 GNB2 ADM2 DRD2 DRD3 GHRH DRD4 GNB1 DRD5 GNB4 TAAR8 GNB3 HTR1E GNB5 HTR1F VIP TAAR9 RAMP1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRB3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CYSLTR1 CYSLTR2 C3AR1 ADORA2B S1PR1 CENPS-CORT;CORT;CENPS CXCL8 OXTR AVPR1B AVPR2 AVP AVPR1A OXT-1 CCL13;CCL2 C5 C3-1 GABBR2 GABBR1 RHO SAA2;SAA1 MCHR1 SSTR3 CCR5 MRGPRD CMKLR1 PDYN AGTR2 FPR1 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 GPR37 GPR35 CXCL2;CXCL3;CXCL1-1 RGR PLPPR1 CCL11 PLPPR2 PLPPR3 PLPPR4 PLPPR5 CCL4L2;CCL4L1;CCL4 CCL19 OPN1SW GPHA2 CCL17 CCL16 CCL25 P2RY12 P2RY13 CCL22 CCL21 CX3CR1 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B CCL3L1;CCL3L3;CCL3;CCL18 PSAP CXCL10 CXCL11 ECE1 PRLHR ADORA2A P2RY4 CCL5 CCL1 APLN ECE2;EEF1AKMT4-ECE2 RRH TAS2R3-1 CXCL5;CXCL6 PTGDR TAS2R16 GPR37L1 KEL TAS2R40 TAS2R41 TAS2R42 SST LHB NLN MC2R PENK PPY CCR10 CCR1 PPBP TAS2R39 HCAR2;HCAR3 ACKR3-2 PTGDR2 NPY4R2;NPY4R CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 OXGR1 FSHB GPBAR1 GAL FSHR OPRD1 PTGER4 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 MAS1 XK NPY2R CCRL2 NPY1R PRH1-TAS2R14;TAS2R14-3 APLNR SUCNR1 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL9 TAS2R8 GRM3 HEBP1 GRM2 GRM4 GRM7 GRM6 ANXA1 GPER1 GRM8 TAS2R1 TAS2R4 PTGIR NPY5R SSTR1 SSTR2 SSTR4 SSTR5 OPRL1 CNR2 CNR1 TAS1R2 S1PR3 TAS1R1 S1PR2 S1PR5 S1PR4 TAS1R3 TSHR CXCL12 ACKR4 ACKR2 ACKR1 CXCR4 NPFFR2 NPFFR1 GRPR EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR2 FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 ADRA2C GPR4 ADRA2B AGT ADRA2A F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR CASR F2R LTB4R2 NTS PF4;PF4V1-1 MCHR2 KNG1 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR P2RY6 P2RY2 P2RY1 CCK HCRTR2 HCRTR1 KISS1 FFAR3;GPR42 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus ITGB3BP NGFR SQSTM1 PSENEN PSEN2 PSEN1 MAPK8 APH1A NCSTN APH1B NGF RPS27A UBB;UBC TRAF6 UBA52 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins WT1 MPHOSPH8 H2AJ CSNK2A1;CSNK2A3 FOXQ1 PRKCSH AGO3;AGO1 TLE1 ZBTB33 ARHGAP32 HDAC2 GANAB PKM SUZ12 H2BC5 HDAC1 H2BC1 CTSS MOGS SMARCA4 MCRIP1 CTSB KLF4 H2AC4 CTNNA1 MYCN RB1 TMEM258 SNAI2 SRC CTNND1 CDH1 TWIST2 SNAI1 CTNNB1 BANP OST4 EPS15 CBLL1 SEC11A OSTC SEC11C STT3A KDM1A MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 CANX DDOST POMT2 DAD1 SPCS3 SPCS2 ZNF217 SPCS1 POMT1 TFAP2A RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TNRC6A-1 MDM2-2 ANK3 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 TGIF2 ARID1A TNRC6B FURIN PCSK6 ZEB1 SIRT1 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VCL PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ZEB2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 KMT5A PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 JUP PSMC5 DNM2 PSMC6 PSMC3 PSMC4 PSMC1 SP1 CTBP2 CTBP1 H2AC14 MYC CSNK2A2 CSNK2B RPN2 RPN1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FOXA2 MTBP MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 PCSK7 ZMYM2 RACK1 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane RPN1 TUSC3 JAK1 PDCD1 PDCD1LG2 DDOST TMEM258 CD274 DAD1 B3GNT3 OST4 OSTC STT3A STT3B MAGT1 MIB2 RPN2 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 POMC OPRM1 GNAQ GNA14 GNA15 GNG13 GNGT1 GNG10 GNA11 GNB2 PDYN GNG2 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation LYVE1 HYAL1 HYAL3 HYAL4 CHP1 GUSB SPAM1 CD44 STAB2 CEMIP SLC17A5 HEXB HMMR HYAL2 HEXA SLC9A1 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants FLT3 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis HS3ST4 HS3ST1 HS3ST2 HS6ST1 HS6ST2 HS6ST3 NDST2 NDST1 NDST4 NDST3 GLCE EXTL2 GPC1 HS2ST1 HSPG2 GPC3 HS3ST3A1 GPC2 SDC4 GPC5 SDC2 GPC4 SLC35D2 EXTL3 SDC3 GPC6 HS3ST3B1 AGRN EXT1 EXT2 SDC1 HS3ST5 HS3ST6 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms NOXA1 NOXO1 RAC1 WNT5A NOX1 FZD7 MAPK8 DVL1 JUN DVL2 DVL3 CYBA SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 HRAS FGF1 FGF2 FGF3 FGF4 FGF6 FGF9 SOS1 FGF20 FGF23 FGF22 NRAS FGF10 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation FGB FGA FGG TLR4 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG LNPEP CHUK PSMC2-1 PSMA5 PSMA6 PSMA3 CD14 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 CTSS PSMD13 S100A1 CD36 PSMA7 TIRAP PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 ITGB5 PSMB3 PSMB1 RPS27A BTK UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 VAMP8 PSMC3 PSMC4 PSMC1 ITGAV S100A9 S100A8 TLR1 TLR6 TLR2 NCF1 NCF2 SNAP23 NCF4 SEC61A2 SEC22B MRC2 SEC61A1 PDIA3 SEC61G SEC61B TAP2 TAP1 FCGR1A TAPBP STX4 MRC1 B2M CYBB CD207 CYBA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CTSV;CTSL LY96 PSME1 PSME2 HMGB1-1 PSMB10 MYD88 PSMB8 PSMB9 CALR-1 VAMP3 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound SNAP25 CACNA2D2 STX1A VAMP2 CASK SYN1 EPB41L1 RAB3A CACNB2 MYH9 DNAJC5 CHRNA9 ATP2B1 TWF1 SPTAN1 RIPOR2 PCLO CLIC5 CAPZB MYO1C CIB2 BSN PJVK SYP EPS8 CABP2 TPRN CACNA1D PLS1 CABP1 TMC1 LRRC52 ESPN-1 OTOF MYO7A SLC17A8 TMC2 CAPZA1 MYO3B CAPZA2 MYO3A KCNMB1 KCNMA1 KCNQ4 FSCN2 CHRNA10 PCDH15 KCNN2 USH1C ESPNL EZR CDH23 OTOG XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 GSN WHRN LHFPL5 SPTBN1 OTOGL TMIE USH1G RDX STRC MSN MYO15A SLC26A5 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 SP1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B RXRA FGF2 AGO3;AGO1 SMAD2;SMAD3 RARA SMAD4 TNRC6A-1 TNRC6C MYOG MYOD1 TNRC6B MYF6 TIMP2 TCF4 TIMP1 MYCN HELLS MYF5 TGFB2 TCF12 TGFB1 INHBA KLF16 ACVR2A TGFBR3 MOV10 MMP14 AGO4 EP300 MMP16 GIPC1 AGO2 INHA TGFBR1-1 TGFBR2 ARRB1 ARRB2 PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism QDPR IL4I1 PAH PCBD1 KYAT1 ASRGL1 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs MTMR4 LTBP1 ITGB8 STRAP PMEPA1 ITGB6 TGFB3 NEDD4L UCHL5 BAMBI PPP1CC ITGA8 SMAD2;SMAD3 SMAD4 FKBP1A SMURF2 SMURF1 SMAD7 UBA52 ITGB1 PPP1CB PPP1CA ITGB5 TGFB2 RPS27A TGFB1 UBB;UBC CBL XPO1 TGFBR3 FURIN ITGB3 TGFBR1-1 TGFBR2 STUB1 PPP1R15A USP15 LTBP4 ITGAV LTBP2 LTBP3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling NRG2 AKT2 AKT3 AKT1 USP8 NRG1 UBA52 RNF41 RPS27A UBB;UBC ERBB2 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly APOB APOC3 MTTP APOC2 APOA2 APOA4 SAR1B APOE APOA1 P4HB DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM-2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression TTF1 SIN3B SAP130 SIN3A UBTF H2AJ SAP30BP POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H BAZ2A TAF1D HDAC2 TAF1B SMARCA5 TAF1C TAF1A H2BC5 HDAC1 H2BC1 H2AC4 ARID4B GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2E POLR1C POLR2F H2BC21 SAP30 POLR1D POLR2H POLR2L GTF2H1 H2AZ2;H2AZ1 SAP30L GTF2H3 SAP18 SUDS3 GTF2H4 CDK7 ERCC3 ERCC2 MNAT1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 TBP H2AB2;H2AB3;H2AB1 DNMT3B DNMT1 MBD2 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation LAMA3 LAMC2 BMP1 LAMB3 COL7A1 TLL2 TLL1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants ALK DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant VWF ADAMTS13 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GAL1 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST6GALNAC2 GALNT1 ST3GAL2 ST3GAL3 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes TP53 ZNF385A PCBP4 CDKN1A CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress SIRT1 RPA1 AKT1S1 NUP43 RPA2 RPA3 HSPA9 RANBP2 ATM YWHAE ATR HSPB8 HIKESHI HDAC6 CCAR2 HSBP1 DNAJC2 EEF1A1 DNAJC7 VCP-1 NUP37 ST13;LOC107986532 CRYAB BAG2 RPS19BP1 HSPA4L HSPA14 HSPA13 DNAJB1 BAG4 BAG5 HSPH1 DNAJB6 BAG3 HSF1 BAG1 HSPA4 HSPA6 HSPA8 HSPA12A HSPA12B CAMK2B CAMK2D CAMK2A GSK3B FKBP4 MAPK1 NUP107 HSPA1L CAMK2G MAPK3 MLST8 HSP90AA1 PTGES3-1 HSPA2 HSP90AB1 MAPKAPK2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 HSPA5 NDC1 NUP85 NUP214 MTOR NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 EP300 NUP133 RPTOR CREBBP HSPA1A;HSPA1B FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER PIAS3 USP45 UBE2I RAD23A CHD1L ERCC5;BIVM-ERCC5 RAD23B PARP1 RPA1 RPA2 GTF2H1 XPA GTF2H3 PIAS1 GTF2H4 XPC CDK7 RPA3 UBE2V2 SUMO1 ERCC3 SUMO3 ERCC2 SUMO2 MNAT1 ERCC4 ERCC1 UBA52 DDB1 CUL4A CUL4B CETN2 RPS27A UBB;UBC RBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNF111 DDB2 PARP2 UBE2N TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death CASP8 FADD TICAM2 TICAM1 TLR4 LY96 RIPK3 CD14 RIPK1 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors PFKFB1 PRKACA-1 PRKACB-1 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism BECN1 JAK1 NUP43 EIF4E RANBP2 KPNA7 KPNA5 USP18;USP41 KPNA2 EIF4G1 KPNA3 PLCG1 UBE2E1 UBA52 STAT1 NUP37 KPNB1 EIF4G3 IFIT1 EIF4G2 EIF4E3 KPNA4-1 NEDD4 RPS27A UBB;UBC EIF2AK2 ISG15 MX1-1 FLNB NUP107 MAPK3 IRF3 UBA7 PPM1B DDX58 NUP205 PIN1 NUP188 AAAS TRIM25 NUP42 NUP62 NUP160 TPR EIF4E2 NUP88 RAE1 KPNA1 ARIH1 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 EIF4A2 NUP133 EIF4A1 UBE2L6 HERC5 EIF4A3 UBE2N P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events MAPKAPK3 MAPKAPK2 RALGDS HRAS MAPK14 RALA-1 RALB MAPK12 MAPK13 MAPK11 NRAS TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F12 KLKB1 SERPING1 F2 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation GSTT2B;GSTT2 GSTA3;GSTA1 GGCT AKR1A1 GSTZ1 GSTA4 GGT7 GGT6 MGST3 GCLC GSTA3;GSTA5;GSTA1;GSTA2 MGST1 MGST2 GSS GCLM GSTP1 GSTK1 GGT1 GSTT1 OPLAH CNDP2 HPGDS ESD CHAC2 GGT5 CHAC1 GSTM4 GSTM3 GSTO1 GSTO2 GSTM1;GSTM2-1 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria ASL RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription TTF1 UBTF H2AJ MBD3 POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H GATAD2B TAF1D GATAD2A HDAC2 TAF1B TAF1C TAF1A H2BC5 HDAC1 H2BC1 MTA1 MTA3 H2AC4 KAT2B KAT2A CAVIN1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2E POLR1C POLR2F H2BC21 POLR1D POLR2H RRN3 MAPK3 POLR2L ERCC6 GTF2H1 H2AZ2;H2AZ1 GTF2H3 GTF2H4 CDK7 ERCC3 ERCC2 MNAT1 EHMT2 H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CHD4 CHD3 CBX3-1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA2 H2AC20 TBP H2AB2;H2AB3;H2AB1 MBD2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly ABCB7 CIAO3 NUBP1 NUBP2 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B ERCC2 RTEL1 BRIP1 POLD1 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions FGFR1 BAG4 ERLIN2 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGF4 FGF9 FGF20 FGF23 FGF16 FGF18 FGFR3 FGF1 FGF2 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNB1 GNB4 GNB3 GNB5 KCNJ2 KCNJ3 KCNJ12;KCNJ18 ADCY4 KCNJ4 GNAI3 ADCY3 KCNJ5 ADCY2 GABBR2 ADCY1 GABBR1 ADCY8 KCNJ6 ADCY7 KCNJ10 GNAI1 ADCY6 GNAI2 KCNJ9 ADCY5 KCNJ15 KCNJ16 GNG10 GNG2 GNG5 GNG4 GNG8 GNAT3 GNAL ADCY9 GNGT1 GNG13 GNB2 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol RPL34 BUD23 RPL10A RIOK1 RPL8 PELP1 RPL9 UTP15 RPL6 WDR36 RPL7 UTP11 TEX10 RPS15 DDX52 RPS14 UTP18 RPS17 SENP3 RPS16 GNL3 RPL18A C1D RPS19 NIP7 RPS18 TSR3 RPL37A-1 HEATR1 DDX21 RPL35 NOL9 RPL38 NOC4L NOL6 EXOSC10 RPS11 PES1 BMS1 RPL39 RRP36 RPS10 RPP14 RPL15-1 DCAF13 RPS13 UTP6 RPS12 UTP4 RPS9 UTP3 RPL21 RIOK3 RPS7 KRR1 RPS8 WDR18 RPL23 WDR12 RPS5 BYSL RPL22 BOP1 RPS6 TSR1 RPSA MPHOSPH6 RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 CSNK1D RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A NOP2 RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 NOP58 UBA52 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 XRN2 EXOSC3 RPS27A EXOSC2 EXOSC1 NOP56 TRMT112 TPTEP2-CSNK1E;CSNK1E LTV1 RPP30 RRP1 FCF1 THUMPD1 RRP9 FBL LOC102724159;PWP2 MTREX UTP14C;UTP14A RPP38 DIMT1 IMP3 WDR75 IMP4 FTSJ3 EBNA1BP2 DKC1 NCL-1 RPP21 NHP2 RPP25 UTP25 ISG20L2 SNU13 RRP7A EMG1 PDCD11 ERI1 DHX37 UTP20 NOP14 PNO1 RPP40 RCL1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NOP10 RBM28 DDX49 RPL4 DDX47 RPL30 WDR3 RPL3 NAT10 WDR46 RPL32 WDR43 NOB1 RPL31 RIOK2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade PIK3CB RAC1 PIK3CG VAV2 SYK PDPK1 VAV1 PIK3CA LCK PRKCZ RHOA CDC42 FYN PTPN11 PIK3R3 PIK3R2 PDPN PIK3R1 MPIG6B PTPN6 FCER1G RHOB PIK3R6 GP6 PIK3R5 LYN RHOG CLEC1B PLCG2 VAV3 LCP2 LAT INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling PTAFR FPR1 CCL13;CCL2 CSF1 TYK2 PTGS2-2 JAK1 CCR1 CSF2 CXCL2;CXCL3;CXCL1-1 CCL4L2;CCL4L1;CCL4 CCR2 CCL19 IL18 CCL22 IL1A IL1B CCL20 STAT3 CCR5 CD86 CD80 IL1RN CSF3 CCL3L1;CCL3L3;CCL3;CCL18 TNF TIMP1 IL12B CXCL10 IL12A ICAM1 IL10RB IL1R2 IL10RA LIF CCL5 TNFRSF1B TNFRSF1A FCER2 IL6 IL10 CXCL8 IL1R1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis LTF GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMD8 NFE2L2 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GSK3B PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation RAC1 VAV1 PRKCD YWHAZ PLA2G4A PDPN MPIG6B CFD FCER1G GP6 ACTN2 SRC SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 VAV3 GTPBP2 ABCC4 SYTL4 CD109 TAGLN2 GP1BA NHLRC2 CLU STXBP3 RAP1A TEX264 STXBP2 PIK3CB MAPK1 LY6G6F;LY6G6F-LY6G6D SERPINA1 VAV2 PIK3CG PDGFB ENDOD1 MAPK3 A1BG APOH PRKCA VTI1B SERPING1 RAB27B PDPK1 MANF MAPK14 CALU MAGED2 PIK3CA HRG F5 FERMT3 LCK SERPINA3 F8 ECM1 OLA1 CTSW ORM2;ORM1 TIMP3 QSOX1 SOS1 CDC42 AHSG CRK ANXA5 SHC1-1 RAPGEF3 RAPGEF4 TOR4A CD63 FYN SPP2 CSK VEGFB VEGFC ACTN1 VEGFD LHFPL2 PCYOX1L PTPN11 MPL F13A1 CFL1 FAM3C LEFTY2;LEFTY1 PTPN6 APLP2 TMX3 TTN-1 SELENOP SCG3 THPO RARRES2 CYRIB THBS1 SELP SCCPDH LGALS3BP WDR1 PLEK PHACTR2 CLEC1B SRGN MMRN1 PECAM1 ITIH4 ITGB3 ITIH3 PLG CLEC3B ARRB1 CDC37L1 AAMP BCAR1 ARRB2 APOA1 RAP1B DGKG DGKE DAGLA FGB DGKD FGA DGKB DGKA VWF ABHD6 FGG ABHD12 PRKCH APBB1IP PRKCE DGKZ DGKQ RAF1 PPIA TLN1 RASGRP1 DAGLB DGKK DGKI VCL DGKH CALM3;CALM1 APP LAMP2 IGF2 IGF1 RHOB TUBA4A PCDH7 GNA14 GNA15 GNGT1 GNA11 HGF TF GNAQ GNA13 PRKCZ TBXA2R RHOA GNA12 P2RY12 GNG10 GNG2 GNG5 GNG4 GNG8 CYB5R1 PSAP RHOG PTPN1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 PPBP APOOL GP9 GP1BB FLNA GP5 GNAT3 TGFB1 A2M BRPF3-1 MGLL PLCG2 VEGFA ITPR1 ITPR2 ALB PTK2 ITPR3 PFN1 SYK GNAI3 GNAI1 GNAI2 CAP1 STX4 TIMP1 TGFB2 SERPINE1 TGFB3 ALDOA PRKCB CD9 EGF PRKCG CD36 TRPC7 F2 TRPC6 TRPC3 ADRA2C ADRA2B ADRA2A F2RL2 F2RL3 ITGA2B FN1 F2R AKT1 PROS1 PF4;PF4V1-1 KNG1 SOD1 HSPA5 PIK3R3 PIK3R2 GAS6 PIK3R1 PIK3R6 PIK3R5 LYN P2RY1 PRKCQ RASGRP2 LCP2 LAT GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis UXS1 B3GALT6 XYLT2 XYLT1 FAM20B GPC1 HSPG2 GPC3 NCAN GPC2 BGN SDC4 GPC5 SDC2 GPC4 DCN SDC3 GPC6 BCAN VCAN AGRN PXYLP1 CSPG5 CSPG4 B4GALT7 SDC1 B3GAT3 B3GAT2 B3GAT1 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases UCHL3 HCFC1 FOXK2 FOXK1 BARD1 MBD5 MBD6 UCHL5 ASXL1 PSMD8 ASXL2 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 BAP1 UBA52 H2AC16;H2AC11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 YY1 PSMB6 PSMB7 PSMB4 H2AC4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A TGFB1 UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 KDM1B PSMC1 RUVBL1 NFRKB ACTR5 ACTR8 INO80C INO80B INO80E INO80D ACTB-1 TFPT MCRS1 INO80 H2AC14 SMAD7 OGT-1 H2AC20 ACTL6A TGFBR1-1 TGFBR2 USP15 UCHL1 SENP8 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors GRIK1 GRIK2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions PAOX MAOB MAOA SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants HBEGF CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA ERBIN ERBB2 GAB1 NRG2 NRG3 SOS1 NRG4 SHC1-1 PLCG1 EGF NRG1 EREG BTC NRAS CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA PTPN11 BTLA TNFRSF14 PTPN6 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly CHD4 CBX3-1 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AZ2;H2AZ1 ADNP2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ADNP H2AJ H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 CBX1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle PLEKHG5 KIDINS220 FRS2 GRB7 KIF14 STMN2 RND1 STIP1 RASAL2 WDR6 PLXNA1 FAM83B ANKRD26;CCDC144A;LOC105375816 VANGL1 FLOT2 DST RRAS2 FRS3 ALDH3A2 TMEM59 CCDC88A PTPN13 FAM135A VANGL2 UBXN11 CPD DLG5 MUC13 PKP4 TXNL1 TFRC PIK3R2 PIK3R1 ARHGAP5 ARHGAP35 RBMX CAV1 DSP LEMD3 DEPDC1B EPHA2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling ROBO1 CAP2 CAP1 CLASP1 ABL1 CLASP2 ABL2 SLIT2 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants PDGFRA TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding CLINT1 APP AP3B1 CPD VAMP2 SH3D19 TPD52 TFRC AP3S2;AP3S1 BLOC1S4 BLOC1S6 SNX2 GBF1 BLOC1S3 SNX5 ARF1 FTH1 TBC1D8B CTSZ SNAPIN CLTB SORT1 AP4E1 DTNBP1 AP4M1 PUM1 AP1G2 TPD52L1 BLOC1S1 GOLGB1 CLVS2 YIPF6 AP4S1 ACBD3 CLVS1 HGS TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 SH3GL2 VAMP7 DNAJC6 DNASE2 CLTC CLTA FTL-1 NAPA SNAP23 AP1G1 TGOLN2 SNX9 AP1S2 AP1B1 AP1S1 AP1S3 STX4 OCRL AP1M2 RAB5C AP1M1 GNS PICALM PIK3C2A GAK IGF2R HIP1R NECAP1 CHMP2A ARRB1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins CASP7 CASP8 DBNL CASP6 CASP3 GAS2 MAPT ADD1 PLEC GSN VIM SPTAN1 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis NRIP1 RXRB NR1H3 RXRA PCK1 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) CEBPB TLN1 CREB3L3 EXTL2 GFPT1 EXTL3 LMNA DIS3 PARN HSP90B1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 SYVN1 EXOSC2 EXOSC1 DCP2-1 ATP6V0D1 ADD1 ATF6 SRPRB-1 MBTPS1 FKBP14 HERPUD1 HYOU1 MYDGF NFYB GSK3A TATDN2 NFYC CREB3L4 CREB3L1 CREB3L2 TSPYL2 DDX11 ATF4 EDEM1-1 CCL13;CCL2 WIPI1 NFYA-1 PDIA6 PDIA5 ERN1 MBTPS2 DCSTAMP CREB3 ACADVL DNAJC3-1 CTDSP2 KDELR3 DDIT3 ATF6B DCTN1 CEBPG CXXC1 EXTL1 CUL7 SSR1 DNAJB9 KLHDC3 PREB ZBTB17 WFS1 ASNS YIF1A EIF2AK3 CREBRF SHC1-1 IGFBP1 SRPRA HDGF TPP1 GOSR2 ATF3 HSPA5 EIF2S2 EIF2S3;EIF2S3B JMJD7-PLA2G4B;PLA2G4B SEC31A SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 EIF2S1 ARFGAP1 DNAJB11 PPP2R5B CXCL8 CALR-1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production DPEP1 CYSLTR1 CYSLTR2 GGT1 GGT5 DPEP2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry E2F4-1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 CDC25B PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 RB1 PSMB3 PSMB1 CDKN1A RPS27A CDKN1B UBB;UBC ADRM1 FZR1 PSMA2-1 CCND1 SEM1 E2F1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 TFDP1 CCNH TFDP2 MAX CCNE2 CDK4 CCNE1 CDK2 CDK7 MNAT1 AKT2 MYC RBBP4 AKT3 AKT1 PTK6 LIN54 CKS1B LIN52 RBL2 LIN37 LIN9 CABLES1 WEE1 E2F5 CCNA2-1 CCNA1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters SLC2A2 SLC6A19 SLC6A3 SLC36A2 SLC6A14 SLC22A18 SLC7A7 SLC7A9 DERL3 DERL1 DERL2 OS9 VCP-1 ABCC9 SEL1L SLC5A5 ABCA1 ABCG8 ABCG5 GCK RNF185 ABCA3 NUP107 KCNJ11 RNF5 ERLEC1 NUP160 NUP85 SLC17A8 SEC13 NUP133 SLC35C1 APOA1 SLC12A3 PSMD8 SLC2A9 NUP43 PSMD6 SLC12A1 PSMD7 SLC12A6 PSMD2 PSMD3 PSMD1 SLC35A1 RANBP2 PSMC2-1 PSMA5 PSMA6 SLC17A5 PSMA3 PSMA4 PSMA1 UBA52 CFTR PSMD12 PSMD11 PSMD14 SLC34A2 PSMD13 SLC34A1 NUP37 SLC40A1 PSMA7 HEPH PSMB6 PSMB7 PSMB4 AVPR1B PSMB5 SLC5A7 AVPR2 PSMB2 AVP PSMB3 AVPR1A PSMB1 RPS27A UBB;UBC SLC11A2 ADRM1 PSMA2-1 SEM1 SLC26A2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GCKR ABCC8 CP SLC2A1 NUP205 NUP188 SLC9A6 HK1 AAAS SLC9A9 NUP42 ABCA12 NUP62 SLC4A4 TPR BSG ABCD1 SLC39A4 NUP88 SLCO2A1 RAE1 SLC27A4 ABCB6 NDC1 ABCC2 NUP214 ABCB4 NUP210 SLC5A2 NUP155 SLC33A1 NUP153 SLC6A5 NUP93 SLC26A4 SLC26A3 NUP50 ABCD4 POM121;POM121C SLC6A2 SLC35A3 NUP35 RHAG SLC4A1 SLC22A12 NUP54 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC1A1 SLC2A10 ABCC6 LMBRD1 ERLIN1 SLC29A3 SLC3A1 SLC1A3 ERLIN2 SLC24A1 SLC24A4 SLC20A2 SLC3A2 ABCB11 SLC35A2 SLC16A1 SLC24A5 SLC6A20 SLC22A5 SLC5A1-1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing NCBP2-1 SRSF2 SRSF6 SF3B4 SF3B5 SRSF7 SF3B2 SF3B3 SF3B6 SRSF1 SF3B1 TXNL4A SNRPD2 SNRPD1 SNRPD3 SNRNP40 SNRPF POLR2A SNRPB POLR2B POLR2C POLR2D SNRPE-2 POLR2E SNRPG-2 POLR2F POLR2G POLR2H POLR2I ZCRB1 POLR2L SNRNP200 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 EFTUD2 PRPF6 PRPF8 YBX1 DDX42 PDCD7 SNRNP35 NCBP1 SNRNP25 DDX23 ZRSR2-1 RNPC3 ZMAT5 SNRNP48 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins DEFB125 DEFB1 DEFB123 DEFB121 DEFB109B DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 TLR1 DEFB114 DEFB135 DEFB107A;DEFB107B DEFB132 TLR2 DEFB110 DEFB130B;DEFB130A DEFB105A;DEFB105B CCR6 DEFB103A;DEFB103B DEFB4A;DEFB4B CCR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis GALE NUS1 GALK1 GALM-2 GALT SRD5A3 GFPT1 DOLK MPI DHDDS DPM1 PMM2 DPM2 DPM3 GNE PGM1 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 CDC37 HSP90AA1 ERBIN ERBB2 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage ALKBH2 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs FLT3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle SLC18A2 RAB3A RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 MAOA UNC13B SNAP25 CPLX1 SYT1 SLC22A2 TSPOAP1 SLC22A1 STX1A VAMP2 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 VCAN AGRN B3GALT6 CSPG5 CSPG4 SDC1 GPC1 HSPG2 GPC3 NCAN BGN GPC2 SDC4 GPC5 SDC2 DCN GPC4 SDC3 BCAN GPC6 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM5A KDM4B KDM4C-1 RIOX2 JMJD6 KDM6A PHF2 KDM5C KDM2A KDM3B KDM3A KDM2B KDM4D KDM1B ARID5B KDM6B PHF8 KDM1A KDM5B KDM7A KDM4A ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions NCL-1 YBX1 KDELR1 TSG101 GBF1 FURIN LYN CLINT1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling ARHGEF11 MYH10 RAC1 ARHGEF12 RHOC MYL6 RHOB ARHGAP35 RND1 ROCK1 ERBB2 ROCK2 RHOA MYL12B MET PLXNB1 MYH11 MYH9 SEMA4D LIMK2 LIMK1 RRAS MYH14 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e DPM1 DPM2 DPM3 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates NME1 GUK1 DTYMK TXN NME4-1 AK1 AK2 TXNRD1 GLRX AK5 AK6 AK7 AK8 AK9 AK4-1 NUDT13 RRM2B RRM1 CTPS2 NME3 CTPS1 DCTD NME6 CMPK1 RRM2-1 DCTPP1 TYMS NME2 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs ATXN3 RAD23A VCP-1 JOSD2 RAD23B JOSD1 PRKN UBA52 RPS27A UBB;UBC TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis AGMO GPAT2 DGAT2 GK DGAT1 LPIN1 LPIN2 LPIN3 MOGAT3 MOGAT2 MOGAT1 GK2 GPAM SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III CHMP4B CHMP3 CHMP4A CHMP6 TUBB2B;TUBB2A SPAST CHMP7 VPS4A CC2D1B IST1 TUBB4B LEMD2 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA4A TUBA8 TUBB3;TUBB6 CHMP2B TUBAL3 TUBA1C CHMP2A TUBA1A TUBB1 CHMP4C TUBA3E;TUBA3C-1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 TICAM2 TICAM1 CD14 TLR8 TLR7 MAP3K8 NFKB2 IRF7 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D SLC15A4 MEF2C MAPK9 MAPK8 TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB CASP8 TASL IRF5 RPS6KA5 TRAF2 TLR9 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium MCHR1 CCT5 CCT3 CCT4 CCT2 SSTR3 TTC8 BBS10 SMO BBS12 TCP1 BBS9 BBS2 BBS7 BBS1 RAB3IP BBS5 BBIP1 BBS4 LZTFL1 MKKS ARL6 CCT8 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation PIK3CB RHOA PIK3R2 NTRK1 PIK3R1 IRS1 PIK3CA NGF IRS2 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 NCOR1 CNTN1 PSENEN TBL1XR1 PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SKP1 TLE1 HDAC5 HDAC2 UBA52 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 MIB2 CUL1 SNW1 JAG2 JAG1 ADAM10 HDAC10 DLL1 HDAC11 MIB1 DLL4 NEURL1B ADAM17 NCOR2 RPS27A NEURL1 KAT2B UBB;UBC NBEA KAT2A NOTCH1 RBX1 DNER TLE4 TLE2 DTX1 DTX2 DLK1 RBPJ HDAC4 MAMLD1 DTX4 CCNC-1 MYC HDAC3 HIF1A NUMB HEY1 MAML2 HEY2 HES1 MAML1 EP300 ITCH CDK8 ARRB1 CREBBP ARRB2 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway TNFAIP3 TAB2 SHARPIN TAB1 USP21 USP4 TRAF1 CYLD OTUD1 RBCK1 IKBKB IKBKG TRADD MAP3K7 CHUK OPTN-1 TRAF2 USP2 BIRC2 BIRC3 XIAP TNF RIPK1 TNFRSF1A RNF31 OTUD7B SPATA2 RACK1 TAB3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 UBE2S CDC26 CDC16 CDC27 PSMA7 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion NEDD4L PPIA PDCD6IP UBA52 CHMP4C CHMP4B CHMP3 CHMP4A TSG101 CHMP6 VPS4B CHMP7 VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D RPS27A VPS37A UBB;UBC VPS37B UBAP1 VPS28 CHMP5 CHMP2B CHMP2A NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer CEBPB MAPK1 BCL2A1 MAPK3 PRF1 FOXM1 ICOS ZC3HC1 AGO3;AGO1 NPM1-2 SKP1 GZMH;GZMB-1 STAT3 HDAC1 CCNB1 CUL1 RPS6 TNRC6C PTPN6 RB1 IL10RA MOV10 RBX1 AGO4 STAT5A AGO2 DNMT1 JUNB ZAP70 IRF4 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5M UPP1 UPB1 TYMP NT5E NT5C AGXT2 NT5C1A DPYS DPYD THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 GNAQ GNA13 TBXA2R GNA14 GNA15 GNG13 GNGT1 GNG10 GNA11 AAMP GNB2 GNG2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression ATF4 CCL13;CCL2 CEBPB NFYA-1 DDIT3 CEBPG ASNS EIF2AK3 IGFBP1 HSPA5 ATF3 EIF2S2 EIF2S3;EIF2S3B EIF2S1 DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 DCP2-1 ATF6 CXCL8 HERPUD1 NFYB NFYC RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway RDH13 ALDH8A1 ALDH1A1 DHRS4 CRABP1 DHRS3 SDR16C5 CYP26A1 ALDH1A3 CYP26B1 ADH4 DHRS9 ADH1C;ADH1B;ADH1A RDH11 ALDH1A2 RDH10 RDH5 RDH14 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling HBEGF NRG2 HRAS NRG3 SOS1 NRG4 SHC1-1 NRG1 EREG BTC NRAS ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport SLC22A3 ABCB1 ABCG2 SLC22A2 SLC22A1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest ZNF385A PCBP4 CDKN1A CDKN1B TP53 E2F1 ARID3A E2F7 E2F8 CCNA2-1 CCNE2 CCNA1 CCNE1 CDK2 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes CACNG7 SPP1 CACNA1H CACNB1 ITGA5 CACNB2 CACNB3 GJA1 CACNA2D1 PANX1 HSPG2 ITGB3 AKT1 P2RX7 PIEZO1 ITGB1 ITGAV ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis PIK3CB PLD1 PIK3R2 AHCYL1 PIK3R1 PLD3 PLPP5 PLPP4 SYK PRKCE PLA2G6 PIK3CA PLD4 FCGR3A;FCGR3B PRKCD PLCG2 PLCG1 FCGR1A CD3G PLD2 ITPR1 ITPR2 ITPR3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer SMAD2;SMAD3 SMAD4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex TAB2 MAP3K7 TAB1 TRAF6 UBA52 IRAK2 RPS27A UBB;UBC TAB3 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2R2A;PPP2R2D ANKLE2 CDK1 SIRT2 VRK1 KPNB1 LEMD2 PPP2R1A PPP2CB;PPP2CA LBR EMD LEMD3 BANF1 LMNB1 CCNB2 CCNB1 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins MAPK8 YWHAG BID YWHAH PPP3R1 PMAIP1 BAD YWHAE AKT2 SFN TP63 AKT3 YWHAZ AKT1 PPP1R13B BCL2 BCL2L11 YWHAQ TP73 BBC3 PPP3CC BMF TP53 E2F1 TP53BP2 TFDP1 TFDP2 YWHAB SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants FLT3 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN NTRK2 DOCK3 RAC1 BDNF GRIN2B SRC G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma GNG5 GNB1 GNG4 GNB4 PIK3CG GNB3 GNG8 GNB5 PIK3R6 PDPK1 PIK3R5 RHOA AKT2 AKT3 AKT1 GNG13 GNGT1 GNG10 GNB2 GNG2 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling JAK2 JAK1 PPIA HNRNPF HSPA9 IL6ST PAK2 SOD2 STAT1 LMNB1 STAT3 ARF1 IL12B IL12A TCP1 SNRPA1 IL10 VAMP7 MTAP RPLP0 ANXA2 GSTO1 P4HB TYK2 GSTA3;GSTA5;GSTA1;GSTA2 CANX RALA-1 CDC42 TALDO1 SOD1 CFL1 CA1 HNRNPA2B1 CAPZA1 PSME2 IL23R IFNG PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 MSN RAP1B DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 GALK1 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy PCNT VCP-1 DYNC1I2 HSP90AA1 PRKN DYNC1I1 RPS27A DYNC1LI1 HSF1 UBB;UBC DYNC1H1 DYNC1LI2 CETN1 PARK7 IFT88 ARL13B UBE2V1 UBA52 CFTR HDAC6 UBE2N FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation TGFBR3 FGF3 GIPC1 FGF22 FGF1 FGF2 FGF10 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling PIK3CD JAK2 IL2RB PIK3CB IL2RA JAK1 CSF2 PIK3CA SOS1 SHC1-1 GAB2 IL2 IL3 PIK3R3 PIK3R2 PIK3R1 PTPN6 IL2RG INPPL1 INPP5D IL5RA CSF2RB CSF2RA JAK3 IL5 IL3RA VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism CYB5A SLC23A2 CYB5R3 SLC2A1 SLC23A1 GSTO1 GSTO2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins C1GALT1 MUC5B MUC20 MUC21 B3GNT7 GALNT11 B3GNT4 GALNT14 GALNT13 B3GNT2 GALNT16 GALNT15 GALNT18 B3GNTL1 GALNT10 GALNT9 B3GNT3 ST6GALNAC2 GALNT8 B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GALNT9;GALNT17 GCNT1 GCNT3 GCNT4 GALNT7 GALNT6 ST3GAL4 GALNT5 GALNT4 GALNT2 ST3GAL1 A4GNT ST3GAL2 GALNTL5 ST3GAL3 GALNTL6 ST6GAL1 ST6GALNAC3 ST6GALNAC4 GALNT1 GALNT12 C1GALT1C1 MUC12 MUC13 MUC15 MUC3A MUC5AC B4GALT6 B4GALT5 MUC1 MUC2 MUC7 MUC4 MUC6 GALNT3 MUC17 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport STOML2 MCUB SPG7 PHB2 SLC8B1 MAIP1 PARL AKAP1 AFG3L2 VDAC2-1 SMDT1 VDAC3 SLC8A3 YME1L1 PMPCB VDAC1 MICU3 PMPCA MICU2 LETM1 MICU1 MCU PHB SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L PI4KA SBF1 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein BID BAK1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors HSP90AA1 APOB HYOU1 SCARF1 HSPH1 CALR-1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GAL1 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST6GALNAC2 GALNT1 ST3GAL2 ST3GAL3 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins MAP2K2;MAP2K1 HBEGF TXNRD1 EEF2 MAP2K7 HSP90AA1 GUCY2C HSP90AB1 CALM3;CALM1 FURIN SNAP25 PDCD6IP SV2C SYT2 PDZD3 CD9 SV2B MAP2K4 SYT1 SV2A VAMP1 STX1A VAMP2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels STIM1 ORAI2 ORAI1 TRPC7 P2RX6 TRPC6 ITPR1 P2RX5 TRPC3 ITPR2 P2RX7 P2RX3 P2RX4 P2RX2 P2RX1 ITPR3 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP73 BCL2L14 RABGGTB RABGGTA NDRG1 TP53 TP53BP2 TP63 PERP PPP1R13B TP53I3 BIRC5 CHM BCL6 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling IL18RAP IL13 IL18R1 ALOX5 IL37 IL18 IL18BP IL4 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily ADNP2 ADNP H2AJ MBD3 GATAD2B GATAD2A HDAC2 H2BC5 HDAC1 PCK1 H2BC1 MTA1 MTA3 H2AC4 UBE2I PWWP2B MBD3L1 H2BC21 PWWP2A MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 H2AZ2;H2AZ1 SUMO1 G6PC1 H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBX1 RBBP7 CHD4 CHD3 CBX3-1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FBP1 MTA2 NR2C2 ZNF592 CHD5 IKZF1 H2AC20 IKZF2 IKZF3 PHF6 H2AB2;H2AB3;H2AB1 ZMYND8-1 ZNF827 ZNF687 TCF19 MBD2 NR2F2 CDK2AP2 CDK2AP1 ZNF532 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins UBE2I H2BC21 H2AZ2;H2AZ1 ZNF331 TRIM28 H2AJ MBD3 ZNF382 ZNF354A;ZNF354B-4 SUMO2 ZNF669;ZNF670 ZNF324B;ZNF324 H2AC14 CBX5 GATAD2B GATAD2A HDAC2 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 RBBP7 HDAC1 ZNF649 H2BC1 ZNF317 CHD4 ZNF30 CHD3 MTA1 H2BC15;H2BC3;H2BC11;H2BC12 MTA3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 MTA2 ZNF264;ZNF805-1 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 H2AC20 H2AB2;H2AB3;H2AB1 ATF7IP SETDB1 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling IL7R SMARCA4 HGF PIK3R3 PIK3R2 JAK1 PIK3R1 TSLP IL7 RAG2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 BRWD1 IRS1 RAG1 CRLF2 IRS2 IL2RG STAT5A CISH STAT5B SOCS2 SOCS1 STAT3 JAK3 KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development WNT9B ITGA8 WT1 FOXC2 FOXC1 SIX1 GATA3 PCDH19 FGF2 SLIT2 HOXD11 HOXC11 WFDC2 HOXA11 LFNG PLAC8 ROBO2 SALL1 SIX2 HOXA6 RET IRX1 IRX2 EMX2 OSR1 GFRA1 ITGB1 WNT11 NPNT PAX2 POU3F3 GREM1 EYA1 BMP4 PAX8 HNF1B GDNF LHX1 ID4 JAG1 HOXB4 WNT4 DLL1 HNF4A MECOM CTNNB1 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors TUT7 EIF4A2 TUT4 EIF4A1 EIF4G1 DIS3L2 PABPN1-1 EIF4E EIF4A3 EIF4B PAIP1 PABPC1;PABPC3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PAK2 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate PECR PHYH-4 SLC25A17 HACL1 SLC27A2 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency OTC DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling CAMKK2 CAMK2G PRKCA PRKCE ADCY4 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 PDE1C ADCY7 KPNA2 PDE1B PDE1A ADCY6 PRKAR1A GRK2 ADCY5 PRKCD PLCG1 PRKCG AHCYL1 PRKACA-1 ADCY9 PRKACB-1 PRKAR1B NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A ITPR1 ITPR2 ITPR3 CAMKK1 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR FDX1 FDXR CYP11A1 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation PTK6 PTPN1 SRMS GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism HS3ST4 HS3ST1 HS3ST2 GALNS CHSY1-1 B3GNT3 IDUA HEXB NCAN ST3GAL4 HEXA BGN GLB1L3 ST3GAL1 DCN GLB1L2 ST3GAL2 BCAN ST3GAL3 VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB ABCC5 SLC35B3 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 HS6ST1 HS6ST2 HS6ST3 NDST2 NDST1 NDST4 NDST3 GLCE OMD HSPG2 HS3ST3A1 SDC4 SDC2 SLC35D2 SDC3 GNS CHST11 CHST12 CHST15 ST3GAL6 CTSV;CTSL CHST13 CHST14 EXT1 EXT2 B4GAT1 SDC1 STAB2 HYAL2 CHST6 CHST7 B3GNT7 B3GNT4 FAM20B B3GNT2 CHST1 SPAM1 CHST2 CD44 CHST3 PAPSS2 PAPSS1 EXTL2 GPC1 HAS1 SLC17A5 GPC3 HAS3 HAS2 GPC2 GPC5 GPC4 EXTL3 GPC6 LYVE1 AGRN FMOD CHPF NAGLU CHP1 SLC26A11 CSGALNACT1 CSGALNACT2 KERA SLC26A2 CEMIP SLC26A1 HMMR DSEL B3GALT6 UST OGN HPSE B4GALT2 B4GALT3 B4GALT1 SGSH HS2ST1 SLC9A1 DSE HS3ST3B1 CHPF2 PXYLP1 B4GALT6 B4GALT7 B4GALT4 B4GALT5 PRELP ACAN CHSY3 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders NCOR1 CAMK4 CALM3;CALM1 TBL1XR1 HDAC3 GPS2 PRKACA-1 SIN3A NCOR2 HDAC1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol BUD23 UTP15 WDR36 UTP11 DDX52 RPS14 UTP18 TSR3 HEATR1 NOC4L NOL6 NOP58 BMS1 RRP36 DCAF13 UTP6 UTP4 RPS9 UTP3 RPS7 KRR1 RPS6 NOP56 TRMT112 NOP2 FCF1 RPS2 THUMPD1 RRP9 FBL LOC102724159;PWP2 UTP14C;UTP14A DIMT1 IMP3 WDR75 IMP4 DKC1 NHP2 UTP25 SNU13 RRP7A EMG1 PDCD11 DHX37 UTP20 NOP14 PNO1 RCL1 TBL3 MPHOSPH10 NOL11 NOP10 DDX49 DDX47 WDR3 NAT10 WDR46 WDR43 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane RAC1 YWHAH EXOC4 EXOC3 EXOC6 LNPEP CALM3;CALM1 EXOC5 YWHAE EXOC2 EXOC1 YWHAZ VAMP2 RAB11A KIFAP3 MYH9 YWHAB MYO5A STXBP3 KIF3B KIF3A YWHAG RALA-1 SNAP23 PRKAA2 AKT2 SFN AKT1 PRKAB2 PRKAB1 STX4 MYO1C YWHAQ C2CD5 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 RAB10 RAB14 RAB13 PRKAG1 RAB8A PRKAG2 EXOC8 RAB4A PRKAG3 EXOC7 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression SP1 TNRC6C MYOG MYOD1 TNRC6B MYF6 TCF4 MYCN HELLS MYF5 TCF12 KLF16 RXRA AGO3;AGO1 TGFBR3 MOV10 AGO4 SMAD2;SMAD3 RARA EP300 SMAD4 AGO2 TNRC6A-1 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism AKR1B1 GALM-2 GALT GALE GALK1 PGM1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG MTRR MTR-1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport SLC16A1 SLC16A7 SLC16A8 EMB SLC16A3 BSG REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL LEFTY2;LEFTY1 ACVR1C CFC1;CFC1B ACVR1B TDGF1 ACVR2B NODAL DAND5 CER1 ACVR2A PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes PITPNB LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy PRKAA2 HSPA8 PRKAG1 PRKAB2 PRKAG2 PLIN2 PRKAB1 PLIN3 PRKAG3 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation HGS RAB5A VPS33B CORO1A KPNB1 NOS2 UBA52 ATP6V1H RPS27A UBB;UBC KPNA1 RAB7A POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation NANOG;NANOGP8 SOX2 ZIC3 SALL4 POU5F1;POU5F1B SALL1 DPPA4 EPHA1 TDGF1 FOXD3 STAT3 FGF2 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation AP2A2 CD4 ARF1 AP2M1 AP2B1 ATP6V1H LCK AP2S1 AP2A1 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) CEBPB MAPK7 RPS6KA1 FOS CDKN2D CDKN2B H2AJ CDKN2C CDKN2A ANAPC15 ANAPC16 JUN ANAPC7 UBE2C UBE2E1 UBA52 H2BC5 UBE2D1 ANAPC10 STAT3 ANAPC11 H2BC1 CDC23 UBE2S CDC26 RELA CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 H2AC4 ANAPC2 CDKN1A RPS27A CDKN1B UBB;UBC FZR1 NFKB1 CDK6 CDK4 CDK2 MAPK1 H2BC21 MAPK3 H2AZ2;H2AZ1 EHMT2 EHMT1 H2AC14 RPS6KA3 RPS6KA2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 IL1A IGFBP7 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 IL6 H2AB2;H2AB3;H2AB1 CXCL8 CCNA2-1 CCNA1 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations POMT1 DAG1 MGAT5B-1 POMGNT1 POMT2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle SLC18A2 SYN3 SYN2 SYN1 RAB3A RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 UNC13B SNAP25 CPLX1 SYT1 TSPOAP1 STX1A VAMP2 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER RAD23A ACTR8 RAD23B INO80C PARP1 INO80B INO80E INO80D COPS7B ACTB-1 COPS7A XPC TFPT MCRS1 INO80 GPS1 COPS3 COPS6 COPS8 UBA52 DDB1 CUL4A COPS4 CUL4B CETN2 COPS2 YY1 RPS27A UBB;UBC RBX1 COPS5 ACTL6A DDB2 RUVBL1 NFRKB PARP2 ACTR5 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs RAC1 H2BC21 RHOC MYL6 YWHAG PPP1R14A PPP1R12A PDPK1 H2AZ2;H2AZ1 PPP1R12B YWHAH H2AJ AR KDM4C-1 KLK3;KLK2 RHOA PAK1 YWHAE H2AC14 SFN YWHAZ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CDC25C H2BC5 PPP1CB MYH14 H2BC1 MYH10 YWHAQ H2BC15;H2BC3;H2BC11;H2BC12 RHOB H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 PKN3 MYL12B H2AC20 H2AB2;H2AB3;H2AB1 MYH11 MYH9 NCOA2 PKN2 KDM1A YWHAB PKN1 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD BCKDHB DBT DLD PPM1K BCKDHA REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response SIRT1 RPA1 NUP43 RPA2 RPA3 HSPA9 RANBP2 ATM YWHAE ATR HIKESHI CCAR2 DNAJC2 DNAJC7 NUP37 ST13;LOC107986532 BAG2 RPS19BP1 HSPA4L HSPA14 HSPA13 DNAJB1 BAG4 BAG5 HSPH1 DNAJB6 BAG3 HSF1 BAG1 HSPA4 HSPA6 HSPA8 HSPA12A HSPA12B GSK3B MAPK1 NUP107 HSPA1L MAPK3 HSPA2 MAPKAPK2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 HSPA5 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 HSPA1A;HSPA1B OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling STXBP2 CSF1 TYK2 CD4 CSF1R JAK1 CSF3 CSF3R IL34 IL16 IFNLR1 IL10RB IFNL2;IFNL3;IFNL1 SDC1 TXLNA PTPRZ1 STX3 CASP3 SNAP25 STX4 STX1A VAMP2 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events NUP43 HNRNPK RANBP2 H2BC5 H2AC16;H2AC11 H2BC1 NUP37 H2AC4 CEBPD NUP107 H2BC21 CHMP1A H2AC14 NUP205 NUP188 AAAS NUP42 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP62 NUP160 TPR NUP88 CHMP4C RAE1 NDC1 CHMP4B NUP85 NUP214 CHMP3 NUP210 CHMP4A NUP155 CHMP6 TSG101 NUP153 H2BC15;H2BC3;H2BC11;H2BC12 NUP93 CHMP7 NUP50 VPS4A POM121;POM121C MVB12B MVB12A NUP35 VPS36 NUP54 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VPS37C VPS37D VPS37A SNF8 VPS37B UBAP1 SEC13 VPS25 VPS28 H2AC20 NUP133 CHMP2B CHMP2A H2BC18 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism AOC1 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 HNMT FTCD EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids CYP4B1 CYP4F22 PTGIS CYP4F3;CYP4F2;CYP4F12;CYP4F11 TBXAS1 CYP8B1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER POLD2 POLE RFC5 RFC3 RPA1 RFC4 RPA2 RFC1 RFC2 POLE4 LIG1 RPA3 RPS27A POLE2 UBB;UBC POLE3 PCNA POLD3 POLD4 UBA52 XRCC1 POLK LIG3 POLD1 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis STARD3NL STAR FDX1 AKR1B1 TSPO FDXR CYP11A1 TSPOAP1 STARD3 STARD4 STARD6 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL3 DERL1 DERL2 OS9 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CFTR PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 ABCD2 ABCD3 PSMA7 ABCC10 PEX3 ABCG1 PSMB6 ABCG4 PSMB7 ABCB5 PSMB4 ABCB8 PSMB5 ABCB9 PSMB2 PSMB3 ABCF1 PSMB1 ABCA2 RPS27A ABCA5 UBB;UBC ABCA4 ABCC9 ADRM1 ABCA9 SEL1L ABCA7 ABCA8 PSMA2-1 SEM1 ABCB10 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ABCG8 ABCC4 ABCG5 ABCC5 RNF185 ABCA3 KCNJ11 ABCB7 ABCC3 RNF5 ERLEC1 ABCA12 ABCA6 ABCD1 EIF2S2 ABCC2 ABCB6 EIF2S3;EIF2S3B ABCB4 EIF2S1 ABCB1 PEX19 ABCC1 ABCC6 ERLIN1 ERLIN2 APOA1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors CALM3;CALM1 DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes RB1 CCNE2 CCNE1 CDK2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions COL4A3 ITGA10 ITGB8 FGB FGA COL9A1 ITGB6 FGG ITGA8 SPP1 COL9A3 COL9A2 CD44 AGRN ITGB5 ICAM1 CDH1 ITGAM ITGB2 TNC ICAM4 ICAM5 ITGAE COMP IBSP ITGAX ITGB7 ITGAV ITGAD CD47 JAM2 JAM3 ITGA11 FBN1 VCAM1 ITGA2B F11R FN1 ICAM2 VTN ICAM3 HSPG2 BSG ITGB1 ITGAL KDR ITGA3 ITGA2 COL18A1 ITGA1 ITGA4 COL16A1 ITGA7 COL13A1 ITGA6 THBS1 ITGA5 ITGA9 COL23A1 PECAM1 ITGB3 COL4A2 COL4A1 LUM COL4A4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis MED9 CDK19 MED28-1 HDAC2 PCK1 HDAC1 UCP1 HNRNPU ANGPTL4 MTA1 PRDM16 KLF4 ZNF423 MTA3 ELOVL3 CIDEA TNF EBF2 LPL FABP4 BMP7 TGFB1 CCND3 PLIN1 CEBPD CDK4 MED31-1 EBF1 EGR2 NCOA3 ADIRF THRAP3 ZNF638 FAM120B ZNF467 LEP SMAD1 SMAD4 CCNC-1 RBBP4 PPARGC1B RBBP7 CHD4 CHD3 SMARCD3 HDAC3 CHD9 MED16 MED15 MED17 MED12 MED14 MTA2 HELZ2 MED13 MED10 TGS1 EP300 ADIPOQ PPARGC1A NCOA1 MED27 MED1 MED26 NCOA2 NR2F2 CREBBP MED23 MED8 NCOA6 MED25 MED4 MED6 MED24 MED7 MED20 CEBPB NCOR1 TBL1XR1 CARM1 MBD3 GATAD2B GATAD2A CD36 RELA SREBF2 NCOR2 NFKB1 MED19 MED18 MED11 MED29 MED22 MED21 MED30 RXRA PPARG PPARA MED13L WNT1 WNT10B CEBPA SLC2A4 KLF5 CDK8 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands TP53 TP53BP2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP63 TP73 FAS TMEM219 PPP1R13B IGFBP3 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation GALE CHSY1-1 HEXB NCAN HEXA BGN MGAT2 DCN BCAN ST3GAL3 VCAN MOGS GLB1 CSPG5 MAN1B1 CSPG4 MPI PMM2 DAG1 GALNT12 SEMA5A DPAGT1 POMT2 SPON2 ALG8 SEMA5B ALG9 SPON1 ALG6 THSD7B ALG2 ALG3 POMT1 ADAMTSL3;ADAMTSL1 ALG12 GALM-2 ALG1 ADAMTSL1 MPDU1 LFNG OMD ADAMTS4 RFT1 ADAMTS5 C1GALT1C1 HSPG2 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 SDC4 ADAMTSL2 ALG14 SDC2 MUC12 MUC13 SDC3 MUC15 THSD7A ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 CHST14 SBSPON MUC3A POMGNT1 MUC5AC EXT1 ADAMTS20 B3GLCT EXT2 CFP B4GAT1 SDC1 THBS2 THBS1 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 MUC2 ADAMTS13 ADAMTS19 DHDDS ADAMTS18 DPM1 ADAMTS17 DPM2 MUC7 DPM3 CHST6 MUC4 MUC6 GNE GALNT3 MUC17 C1GALT1 MUC5B MUC20 MUC21 NEU1 CTSA NUS1 CHST3 PAPSS2 SRD5A3 GFPT1 DOLK GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN FMOD KERA NOTCH1 SLC26A2 ALG11 B3GALT6 OGN GALK1 B4GALT1 PGM1 NOTCH2 NOTCH3 NOTCH4 B4GALT7 GALT PRELP ACAN B3GAT3 LUM DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm CXCR4 FOXA2 GATA4 CDH1 SMAD2;SMAD3 CTNNB1 SMAD4 EOMES GATA6 TBXT SOX17 GSC MIXL1 TCF7L2 SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections TAB2 TAB1 JAK1 NOD1 VAV1 YWHAH NOD2 IRAK2 ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 HDAC2 GANAB FUT8 YWHAZ TRAF3 MAN2A1 IKBKE MGAT5 BRD4 ST3GAL4 MGAT1 MGAT2 STAT1 ST3GAL1 ST3GAL2 TLR8 HDAC1 ST3GAL3 TLR7 ST6GAL1 EDEM2 VCP-1 MOGS TUSC3 GOLGA7-1 MTA1 MGAT4C ZDHHC9 MGAT4B ANO8 MAN1B1 MTA3 ANO9 ST6GALNAC3 ANO6 ST6GALNAC4 ANO4 SH3KBP1 ANO5 TMEM258 ANO2 CAV1 ANO3 MBL2-1 ANO1 MASP1 OST4 IRF7 OSTC STT3A ANO10 STT3B GSK3A PARP6 PRMT1 YWHAB PARP4 GSK3B GALNT1 PARP16 PARP9 STING1 PARP14 PARP8 PARP10 IMPDH1 IMPDH2 YWHAG PDPK1 DDOST DAD1 HSP90AB1 ROCK1 NPM1-2 ROCK2 SMAD4 SOS1 SFN RBBP4 RBBP7 PTPN11 CTSV;CTSL PTPN6 PDCD1 EP300 FURIN CREBBP JAK2 BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG ISCU NFE2L2 PPIA MBD3 GJA1 FKBP1A GATAD2B YWHAE GATAD2A VHL TUFM SEC23A SAR1B RBX1 SEC24B SEC24A SEC24D-1 SP1 VPS33A PATJ VPS33B SEC24C MPP5 ZCRB1 CRB3 G3BP1 G3BP2 CSNK1A1 TUBB4A;TUBB;TUBB8B;TUBB8 ZBP1 TBK1 IRF3 CASP1 DDX58 NUP205 IFIH1 RNF135 NUP188 PCBP2 SIKE1 AAAS RIPK3 MAVS TRIM25 NUP42 SRPK2 BST2 NUP62 SRPK1 TPR NUP88 ITGB1 RAE1 CHMP4C NDC1 CHMP4B NUP214 SFTPD CHMP3 NUP210 CHMP4A NUP155 NLRP12 NUP153 CHMP6 NUP93 ITGA4 CHMP7 IL17F NUP50 POM121;POM121C IL17A NUP35 NUP54 PPIH PPIG RIPK1 PPIB ITCH CHMP2B CHMP2A CNBP-1 VPS39 VPS18 ATG14 VPS11 VPS16 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 CUL3 AP2A1 HNRNPA1-1 AP2A2 KPNA2 RPS11 RPS10 AP2M1 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA PYCARD CYSLTR1 RCAN3 KPNB1 RB1 BTK AP2S1 ATP1B2 ISG15 LARP1-1 ATP1B1 RPS25 RPS29 RPS20 PLCG2 RPS21 ARID4A RPS24 AP2B1 ARID4B VPS41 RPS23 FNTA NLRP3 ATP1A4 BLNK VPS45 KDM1A HMG20B JAK3 ATP1A3 IL1R1 FKBP4 ATP1A2 IFNGR1 DDX5 IFNGR2 RPS4X SIGMAR1 ATP1A1 NUP107 NMI TYK2 SAP30 BRMS1 TOMM70 IFNAR1 HSP90AA1 IL17RC PHF21A ATP1B3-1 CD79B IL17RA RPS3A CD79A SYK TLR1 PTGES3-1 CANX FXYD2;FXYD6-FXYD2 SAP30L S1PR1 SAP18 TLR2 RPS27L SUDS3 FXYD4 RPS15A CRBN FXYD3 STAT2 RCOR1 RPS3 FXYD1 FNTB;CHURC1-FNTB FXYD6 IRAK1 RPS2 SMAD2;SMAD3 NRP1 HSPG2 NCK1 FAU NUP160 SDC4 SDC2 SDC3 NUP85 CHD4 CHD3 RUNX1 YWHAQ RPS27 MTA2 SDC1 REST SEC13 NUP133 NUP43 IKBKB IFNB1-4 IKBKG RANBP2 MAP3K7 CHUK GPC1 GPC3 TMPRSS2 ACE2 UBA52 GPC2 GPC5 GPC4 BCL2L1 GPC6 EEF1A1 NUP37 AGRN RELA RPS27A UBB;UBC GEMIN2 SNRPD2 NFKB1 SNRPD1 TJP1 SNRPD3 NFKBIA SMN2;SMN1 PSMC6 GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 TKFC SNRPB DDX20 SNRPE-2 SNRPG-2 UBE2I COMT NR3C1 PIK3R4 SUMO1 AKT2 AKT3 AKT1 B2M TLR9 PIK3C3 RPN2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RPN1 RIPK2 IL6R KEAP1 TRAF6 UBE2V1 MAGT1 UBE2N TAB3 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis CGA HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 LHB LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake NR1H2 RXRB MYLIP NR1H3 RXRA ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events CHRND CHRNG CHRNE CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions RPS15 RPS14 RPS17 RPS16 YWHAH PPIA RPS19 RPS18 IRAK2 HNRNPA1-1 KPNA2 FKBP1A YWHAE RPS11 RPS10 YWHAZ TRAF3 IKBKE RPS13 RPS12 RPS9 UBA52 RPS7 RPS8 BCL2L1 TLR7 RPS5 EEF1A1 RPS6 RPSA RELA PYCARD RCAN3 KPNB1 CAV1 RPS27A UBB;UBC NFKB1 RPS25 NFKBIA RPS29 PSMC6 RPS20 RPS21 RPS24 NLRP3 RPS23 YWHAB TKFC RPS4X STING1 SP1 UBE2I NMI TOMM70 MPP5 YWHAG RPS3A PDPK1 RPS27L RPS15A TBK1 IRF3 RPS3 NPM1-2 CASP1 SMAD2;SMAD3 RPS2 SMAD4 DDX58 IFIH1 SFN SIKE1 PCBP2 RIPK3 MAVS TRIM25 BST2 FAU SFTPD YWHAQ RUNX1 RPS27 PPIH PPIG PPIB EP300 ITCH TRAF6 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 GNAT3 GNAI3 GNAI1 GNAI2 P2RY12 GNG13 GNGT1 GNG10 GNB2 GNG2 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing BUD23 RIOK1 PELP1 UTP15 WDR36 UTP11 TEX10 DDX52 UTP18 SENP3 GNL3 C1D NIP7 TSR3 HEATR1 DDX21 NOL9 NOC4L NOL6 EXOSC10 PES1 BMS1 RRP36 RPP14 DCAF13 UTP6 UTP4 UTP3 RIOK3 KRR1 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 CSNK1D NOP2 MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN HSD17B10 MRM2 MRM3 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 XRN2 EXOSC3 EXOSC2 EXOSC1 NOP56 TPTEP2-CSNK1E;CSNK1E NCL-1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 NOP58 UBA52 RPS27A TRMT112 LTV1 RPP30 RRP1 FCF1 THUMPD1 RRP9 FBL LOC102724159;PWP2 MTREX UTP14C;UTP14A RPP38 DIMT1 IMP3 WDR75 IMP4 FTSJ3 EBNA1BP2 DKC1 RPP21 NHP2 RPP25 UTP25 ISG20L2 SNU13 RRP7A EMG1 PDCD11 ERI1 DHX37 UTP20 NOP14 PNO1 RPP40 RCL1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NOP10 RBM28 DDX49 DDX47 WDR3 NAT10 WDR46 WDR43 NOB1 RIOK2 GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV GBE1 GYS2 GYG2 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells UPK1A EPCAM REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation MOV10 AGO4 TNRC6C AGO2 TNRC6B CD274 TNRC6A-1 AGO3;AGO1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants KIT PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) FGB FGA VWF FGG ADRA2C ADRA2B SYK PDPK1 ADRA2A APBB1IP RASGRP1 TLN1 ITGA2B FN1 SOS1 CRK SHC1-1 RAPGEF3 AKT1 RAPGEF4 CSK GP9 GP1BB MPL GP5 THPO SRC ITGB3 PTPN1 RASGRP2 F2 GP1BA BCAR1 RAP1B RAP1A PTK2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R IGF2 IGF1 HRAS SOS1 NRAS IGF1R EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling EFNA2 RAC1 PSENEN PSEN2 EPHA1 PSEN1 KALRN APH1A NCSTN APH1B RASA1 AP2A1 AP2A2 PAK1 GRIN2B AP2M1 TIAM1 PAK3 PAK2 LIMK2 LIMK1 MYH14 MYH10 ADAM10 CLTB ARHGEF28 AP2S1 GRIN1 MYL12A MYL12B MYH11 VAV3 MYH9 AP2B1 ARPC4 CLTC ARPC5 CLTA PTK2 ARPC2 ARPC3 ACTR3-1 ARPC1B VAV2 ARPC1A HRAS WASL MYL6 ACTR2 ARHGEF7 NGEF ACTB-1 ROCK1 ROCK2 RHOA CLTCL1 CDC42 ACTG1 NCK2 GIT1 EPHB2 FYN SDC2 ITSN1 CFL1 DNM1 LYN SDCBP EPHB6 YES1 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 MMP9 EPHA3 EPHA10 EFNA5 EFNA4 EFNB2 EFNB1 EPHA2 EFNB3 EFNA1 EFNA3 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) DNMT3L SPOCD1 C19orf84 PIWIL4 SMARCB1 H2AJ SMARCC1 MBD3 SMARCC2 GATAD2B SMARCD1 GATAD2A HDAC2 SMARCD2 H2BC5 HDAC1 H2BC1 SMARCA2 SMARCE1 SMARCA4 MTA1 MTA3 H2AC4 H2BC21 H2AZ2;H2AZ1 ACTB-1 H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CHD4 CHD3 SMARCD3 H2BC15;H2BC3;H2BC11;H2BC12 ARID1A ARID1B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA2 BCL7A BCL7C DPF1 BCL7B H2AC20 DPF2 DPF3 SS18 H2AB2;H2AB3;H2AB1 SS18L1 ACTL6A DNMT3A SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL H2AJ AGO3;AGO1 TLE1 HDAC5 HDAC2 YWHAZ ST3GAL4 HDAC8 H2BC5 HDAC9 STAT1 HDAC6 HDAC1 HDAC7 MIB2 ST3GAL3 H2BC1 SNW1 ATP2A3 ATP2A2 HDAC10 ATP2A1 HDAC11 H2AC4 FABP7 SEL1L PLXND1 CCND1 WWC1 FCER2 E2F1 DLGAP5 PTCRA E2F3 PBX1 DNER TACC3 TLE4 TLE2 TFDP1 DTX1 DTX2 TFDP2 DLK1 RBPJ MAMLD1 H2BC21 TMED2-1 H2AZ2;H2AZ1 SMAD2;SMAD3 LFNG CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TNRC6A-1 YBX1 TNRC6C RUNX1 ST3GAL6 HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 WWP2 TNRC6B NUMB HEY1 MAML2 HEY2 HES1 MAML1 EP300 FURIN ARRB1 CREBBP ARRB2 CNTN1 NCOR1 TBL1XR1 POGLUT1 POFUT1 MFNG PSMD8 FLT4 EGFR MDK PSMD6 ACTA2 PSMD7 SIRT6 RFNG PSMD2 ELF3 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 JUN PSMA6 PSMA3 PSMA4 PSMA1 EGF UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 JAG2 JAG1 PSMB6 ADAM10 PSMB7 DLL1 PSMB4 PSMB5 MIB1 DLL4 PSMB2 NEURL1B PSMB3 ADAM17 PSMB1 NCOR2 RPS27A NEURL1 NBEA KAT2B UBB;UBC KAT2A ADRM1 NOTCH1 RBX1 PSMA2-1 TP53 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 HDAC4 DTX4 B4GALT1 H2AC14 MYC GZMH;GZMB-1 AKT1 RAB6A NOTCH2 NOTCH3 HIF1A NOTCH4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PRKCI MOV10 ELANE AGO4 H2AC20 AGO2 ITCH H2AB2;H2AB3;H2AB1 CDK8 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis NGFR RHOA ARHGDIA LINGO1 NGF MAG MCF2 OMG RTN4 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH GGT1 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria KHK BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA ECHS1 HADH ACADS HADHA HADHB-1 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) SLC16A1 BSG SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) DUSP6 DUSP7 RPS6KA1 FOS AP2A1 AP2A2 AP2M1 STAT3 FOSB ID1 SH3GL3 AP2S1 EGR1 SH3GL2 SHC2 AP2B1 SHC3 RALB YWHAB CRKL CLTC NRAS RAP1A CLTA MAP2K2;MAP2K1 PIK3CB MAPK1 RALGDS HRAS EGR2 MAPK3 NTRK1 KIDINS220 BRAF FRS2 PPP2R1B MAPK14 PPP2R1A RALA-1 NGF PIK3CA MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK RPS6KA3 SHC1-1 RPS6KA2 ATF2 CHD4 DNM1 DNM3 PPP2CB;PPP2CA REST EP300 SGK1-1 PPP2R5D MEF2D JUNB MEF2C MAPK7 NAB1 NAB2 NTRK2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 PLCG1 ID3 DNAL4 ELK1 ID2-1 LYL1 F3 VGF ASCL1 CDK5R2 CDK5 CDK5R1 TCF12 DNM2 IRS1 ADCYAP1 IRS2 ADCYAP1R1 RHOA RPS6KA5 PIK3R2 PIK3R1 ID4 JUND ADORA2A SRF ATF1 DUSP4 MEF2A DUSP3 VRK3 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation WSB1 FBXO2 AMER1 PALB2 FBXL8 FBXL4 FBXL7 DCAF13 UBE2D1 LRRC41 GAN VCP-1 GPR75-ASB3;ASB3-1 KLHL2 KLHL3 KLHL9 SPSB2 SPSB1 KLHL5 KBTBD8 SPSB4 FBXO27 COPS5 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 FBXO15 WDR5 LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 KLHL42 CUL7 CUL5 GPS1 KLHL11 KLHL13 RBBP5 FBXO44 FBXO41 FBXO40 BTBD1 RBBP7 UBE2F KLHL25 ZBTB16 COPS4 KLHL21 COPS2 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 ELOC-1 UBA3 ELOB KBTBD13 DDB2 SENP8 UCHL3 ASB13 ASB14 NFE2L2 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 ASB16 FBXL20 DCAF7 ASB10 VHL FBXO4 FBXO6 FBXL19 FBXL18 FBXL15 FBXW4 FBXL16 DCAF8 FBXL13 DCAF5 FBXL14 DCAF6 FBXW10;CDRT1 FBXL12 WSB2 FBXW5 DCAF4;DCAF4L2;DCAF4L1 ASB8 COMMD5;LOC101928879 ASB9 OBSL1 FBXW7 ASB6 DCUN1D5 DCUN1D3 FBXW9 DCUN1D4 FBXW2 ASB7 DCUN1D1 ASB4 COMMD8 COMMD9 ASB5 PUM2 ASB2 HIF3A DDA1 ASB1 ANKRD9 RBX1 COMMD2 COMMD3 CISH COMMD1 COMMD6 COMMD7 SOCS2 COMMD4 SPSB3 CCDC8 CAND1 CUL9 UBD NAE1 SOCS6 SOCS5 WDTC1 SOCS3 CCDC22 DCUN1D2-1 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B NEURL2 ERCC8 FBXO32 FBXL3 FBXL5 UFD1 NPLOC4 CUL3 KBTBD7 DDB1 CUL4A DTL CUL4B CDKN1A SKP2 CUL2 BIRC5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 UBE2D3-1 SQSTM1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 MUL1 DPP3 COPS7B COPS7A UBXN7 COPS3 COPS6 COPS8 BRCA1 EPAS1 HIF1A COP1 LRR1 CCNF KEAP1 FBXO7 UBE2D3;UBE2D2 FBXO9 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair PARP1 FEN1 POLB PARG LIG1 APEX1 PARP2 ADPRS PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation CACNG8 CAMK2G SCN2A SCN2B CACNG4 CACNA1C CACNG6 FGF14 CALM3;CALM1 RANGRF FGF13 SCN11A FGF12 FGF11 SCN9A SCN5A CACNA2D2 SCN1B SCN1A CACNG7 SCN10A SCN8A SCN4A CACNB1 CACNB2 SCN4B SCN7A CAMK2B SCN3B CAMK2D SCN3A CAMK2A SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins UBE2I PCGF2 NUP107 RNF2 NUP43 HNRNPK RANBP2 SUMO1 SUMO2 NOP58 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 CBX8 NUP50 HNRNPC POM121;POM121C PHC2 NUP35 NUP54 PHC1 CBX4 CBX2 PHC3 SEC13 NUP133 BMI1 RING1 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling PTPN11 JAK2 CUL1 RBX1 SKP1 PRL STAT5A STAT5B PRLR GHR BTRC NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes EP300 TALDO1 G6PD MAFG NFE2L2 TKT CREBBP PGD REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells PDX1 HNF1B PTF1A ONECUT1 NKX6-1 FGF10 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA POLD2 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FZR1 SKP2 CCNE2 CCNE1 CDK2 GINS1 GINS2 CDC45 LIG1 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CCNA2-1 CCNA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDC6 POLE RFC5 GMNN RFC3 RFC4 RFC1 CDT1 FEN1 RFC2 ORC5 ORC4 ORC6 ORC1 DNA2 MCM8 ORC3 ORC2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis ST6GAL1 MUC5B MUC20 MUC21 MUC3A ST6GALNAC3 MUC5AC ST6GALNAC4 ST6GALNAC2 MUC1 MUC2 ST3GAL4 MUC7 MUC4 MUC12 ST3GAL1 MUC6 MUC13 ST3GAL2 MUC17 MUC15 ST3GAL3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination POLR3E POLR2E POLR1C POLR2F POLR3F POLR1D POLR2H POLR3G POLR3H POLR2L POLR3K CRCP SSB NFIX NFIA POLR3GL NFIB NFIC POLR3A POLR3B POLR3C POLR3D APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation H1-3 H1-2 H1-5 CASP3 H1-4 KPNB1 DFFB DFFA HMGB1-1 HMGB2 H1-0 KPNA1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 ATM RAD52 RAD1 ERCC4 RAD9B ERCC1 RAD9A ATR MRE11 BRCA1 KAT5 EXO1 NBN TOPBP1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A ABL1 HUS1 LIG1 DNA2 RHNO1 BLM WRN BRIP1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration RAC1 RHOA MET PLXNB1 ARHGAP35 SEMA4D RRAS RND1 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling MAPK1 MAPK3 BRAF FRS2 KLB PPP2R1A FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 UBA52 MKNK1 FGFR4 SPRY2 PTPN11 PPP2CB;PPP2CA RPS27A UBB;UBC CBL ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects RB1 CDKN1C CDKN1A CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription E2F4-1 CDC6 RBBP4 HDAC1 CDK1 LIN54 LIN52 LIN37 CDT1 RBL2 LIN9 RBL1 CDC45 ORC1 FBXO5 E2F1 TK1 E2F5 DHFR2;DHFR RRM2-1 TYMS E2F6 PCNA TFDP1 POLA1 TFDP2 CCNA1 CCNE1 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation HGFAC SPINT1 HGF HPN MET SPINT2 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate NANOG;NANOGP8 ZIC2 SOX2 PAX6 ZEB2 SOX1 POU5F1;POU5F1B GBX2 OTX2 POU3F1 ZNF521 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair TERF2IP POLD2 RPA1 RPA2 POLE4 H2AJ RPA3 POLE2 POLE3 TERF1-1 H2BC5 POLB APEX1 XRCC1 LIG3 H2BC1 H2AC4 PARP2 H2BC21 PARP1 H2AZ2;H2AZ1 PARG ADPRS H2AC14 MPG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TINF2 OGG1 NTHL1 TDG MBD4 SMUG1 POLE NEIL3 NEIL2 PNKP NEIL1 RFC5 H2BC15;H2BC3;H2BC11;H2BC12 RFC3 RFC4 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD FEN1 RFC2 LIG1 H2AC20 H2AB2;H2AB3;H2AB1 PCNA POLD3 POLD4 TERF2 POT1 POLD1 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 FMOD OMD PRELP ACAN OGN LUM KERA ST3GAL3 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates RBBP8 BARD1 XRCC2 XRCC3 PALB2 SLX1A;SLX1B RAD50 RAD51 ATM MUS81 MRE11 BRCA1 BRCA2 KAT5 EME2 EXO1 NBN GEN1 RMI2 RMI1 TOP3A SPIDR RAD51B RAD51D RAD51C DNA2 SEM1 BLM C1orf112 EME1-1 RAD51AP1 WRN BRIP1 SLX4 FIGNL1 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids CYP2D6;LOC107987479;LOC107987478-1 CYP2J2-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 CYP4B1 CYP4F22 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2F1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1MW3;OPN1MW2;OPN1MW;OPN1LW VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNQ2 KCNQ4 KCNG1 KCNG2 KCNQ3 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ5 KCNV1 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency CPS1 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes EP300 ABCF2-H2BE1;ABCF2 MAFK ABCG2 ABCC1 NFE2L2 CREBBP ABCC3 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly HSP90AA1 IPO5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins FGB FGA VWF FGG APBB1IP SRC TLN1 ITGA2B FN1 SOS1 ITGB3 PTK2 RAP1B RAP1A INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling STAT5A IL9 STAT5B IL9R JAK1 STAT1 STAT3 JAK3 IL2RG GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination TERF2IP NEIL3 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 ACD H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ TERF1-1 H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 MPG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 TERF2 H2BC1 POT1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 NEK9 NEK6 NEK7 CDK1 PLK1 CCNB2 CCNB1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex ORC1 MCM8 ORC3 ORC2 CDC6 ORC5 ORC4 ORC6 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion APOBEC1 APOBEC2 A1CF SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease HRAS FGFR1 FRS2 PIK3CA FGF1 FGF2 FGF4 FGF6 GAB1 FGF9 SOS1 FGF20 FGF23 TRIM24 GAB2 PLCG1 STAT1 STAT3 BCR PIK3R1 CUX1 BAG4 FGFR1OP2 MYO18A CPSF6 ERLIN2 CEP43 STAT5A LRRFIP1 STAT5B NRAS ZMYM2 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME ABCG2 ALB SLC22A1 SLCO1A2 SLC22A8 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation GLYATL3 ACSM5 GLYAT ACSM4 ACSM1 ACSM2A;ACSM2B SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions SDK1 SDK2 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism ME2 PDK2 PDK1 GSTZ1 PDHX FAHD1 PDHA1 SIRT4 ARMC8 PC PDP1 MKLN1 LDHA;LDHC GID4 PDP2 ME1 GID8 LDHAL6B UBA52 DLD RPS27A WDR26 UBB;UBC VDAC1 GLO1 GPT PDHB RMND5B LDHB LDHA MAEA RMND5A PDPR MPC1 MPC2 PDK4 MPC1L PDK3 NEK1 ME3 RANBP9 DLAT BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding KLB FGF19 FGFR4 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells SLC38A1 GLUL SLC1A2 SLC1A3 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation TLR3 OPTN-1 TICAM1 TANK TRAF3 IKBKE UBA52 RPS27A TBK1 UBB;UBC STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses STING1 TBK1 IRF3 NLRP4 DTX4 CGAS DDX41 MRE11 PRKDC IFI16 STAT6 XRCC6 XRCC5 TRIM21 TREX1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium GBF1 PKD2 PKD1 RAB11A ARF4-1 RAB11FIP3 EXOC4 CNGA2 EXOC3 EXOC6 CNGA4 RHO EXOC5 RAB3IP CNGB1 EXOC2 EXOC1 RAB8A ASAP1 EXOC8 EXOC7 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer RAC1 EGFR VAV1 PDGFRB NTRK2 TRAT1 NTRK3 BDNF PIK3AP1 GAB1 NTF4 TGFA NTF3 EGF KIT AREG EREG BTC EPGN HBEGF FLT3LG CD86 CD80 SRC MET NRG1 FLT3 PIK3CD PIK3CB PIK3CG HGF PDGFB CD19 ESR1 FRS2 KLB IRS1 PIK3CA IRS2 LCK FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 STRN GAB2 ESR2 FGF16 FYN FGF19 FGF18 FGFR4 FGF10 PTPN11 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 ERBB2 RHOG NRG2 NRG3 CD28 NRG4 PDGFRA SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT JAK2 RAC1 HRAS PRKCA GRB7 VAV1 PIK3CA LCK PTPRU SH2B3 SOS1 SH2B2 CMA1 FER GAB2 TEC FES FYN GRAP SOCS1 STAT1 KIT CHEK1 STAT3 PTPN11 PIK3R3 PIK3R2 PIK3R1 PTPN6 GRAP2 LYN YES1 CBL GRB10 STAT5A STAT5B MMP9 SOCS6 NRAS CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints RBBP8 ATRIP BARD1 RPA1 BRCC3 RPA2 CLSPN TP53BP1 BABAM1 YWHAH RAD50 BABAM2 UIMC1 RPA3 ABRAXAS1 RNF8 RAD17 RNF168-1 ATM NSD2 RAD1 RAD9B RAD9A ATR ANAPC15 ANAPC16 YWHAZ ANAPC7 UBE2C PLK1 H2BC5 UBE2E1 UBE2D1 ANAPC10 ANAPC11 H2BC1 CCNB1 CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MDC1 YWHAB GSK3B H2BC21 YWHAG MAPK14 UBE2V2 MAPK11 SFN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 CDC45 MCM7 XPO1 MCM3 MCM4 MCM5 MCM6 MCM2 GTSE1 YWHAE CDC25C CDC25A RBX1 TP53 CSNK1A1 TPTEP2-CSNK1E;CSNK1E CDC6 NEK11 WEE1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 PKMYT1 CDKN1A CDKN1B CCNE2 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 MDM2-2 RCC2 NDC80 YWHAQ ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B MDM4 PPP2R5A PPP2R5D PPP2R5C RANGAP1 CCNA2-1 CKAP5 KIF2A INCENP BIRC5 KIF2C CCNA1 KIF2B ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC PSMD8 NUP43 BUB3 PSMD6 PLK3 BUB1 PSMD7 DYNC1I1 PSMD2 CLASP1 PSMD3 CLASP2 PSMD1 CENPT CDKN2A RANBP2 BTRC DYNC1H1 CENPU SKP1 CDC7 NDE1 CENPE CENPF CENPH FBXW11 PSMC2-1 CENPI PSMA5 TAOK1 PSMA6 CENPK PSMA3 CENPL PSMA4 CENPM PSMA1 B9D2 UBA52 CENPO CENPP CENPQ PSMD12 SPC24 PSMD11 SPC25 PSMD14 MAD2L1 PSMD13 CUL1 NUP37 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PIAS4 MRE11 BRCA1 KAT5 EXO1 CHEK1 NBN TOPBP1 PHF20 CHEK2 RFC5 RMI2 ZNF385A COP1 RFC3 PCBP4 RFC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RMI1 RFC2 TOP3A MCM10 HUS1 DBF4 DNA2 RHNO1 BLM HERC2 WRN BRIP1 UBE2N INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade AGRN VWF F10 F5 SDC1 F8 F7 GPC1 F9 HSPG2 GPC3 PROS1 F2 GPC2 SDC4 SERPINC1 GPC5 SDC2 F3 GPC4 SDC3 GPC6 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 NEK2 PSMB5 PSMB2 PSMB3 CD274 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 COPS5 PSMC3 PSMC4 PSMC1 GSK3B GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation DAB2 GJA1 CLTCL1 DNM1 DNM2 AP2M1 MYO6 CLTB CLTC CLTA AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation PSENEN FGA APH1A NCSTN APH1B USP9X SIAH2 SIAH1 APP UBA52 H2BC5 APOA4 LYZ-1 APOE CALB1 BACE1 H2BC1 MFGE8 APCS PRL TSPAN33 CST3 TTR TSPAN5 ODAM ADAM10 NAT8-2 SNCAIP H2AC4 SORL1 TSPAN15 TSPAN14 TGFBI RPS27A ITM2B UBB;UBC INS;INS-IGF2 H2BC21 NPPA H2AZ2;H2AZ1 IAPP CALCA H2AC14 HSPG2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 B2M LTF SNCA H2BC15;H2BC3;H2BC11;H2BC12 PRKN H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GGA2 GGA1 GGA3 H2AC20 UBE2L6 FURIN H2AB2;H2AB3;H2AB1 GSN SAA2;SAA1 APOA1 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYS1 GYG1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling MUC20 HGF HRAS SOS1 MET NRAS RANBP10 RANBP9 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest E2F4-1 CARM1 CDK1 ZNF385A RBL2 AURKA RBL1 EP300 TP53 GADD45A SFN PCNA BAX CDC25C TFDP1 TFDP2 PRMT1 CCNB1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) POLQ RBBP8 RAD52 PARP1 MRE11 BRCA2 FEN1 RAD50 PARP2 XRCC1 LIG3 NBN MMR%REACTOME%R-HSA-5358508.3 MMR POLD2 MSH6 MSH2 MSH3 RPA1 PMS2 RPA2 MLH1 LIG1 RPA3 PCNA POLD3 POLD4 EXO1 POLD1 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors DRD4 DRD5 DRD1 DRD2 DRD3 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors STAB2 SPARC APOB STAB1 DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins DEFB125 DEFB1 DEFB123 DEFB121 DEFB109B DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 TLR1 DEFB114 DEFB135 DEFB107A;DEFB107B DEFB132 TLR2 DEFB110 DEFB130B;DEFB130A DEFB105A;DEFB105B CCR6 DEFB103A;DEFB103B DEFB4A;DEFB4B CCR2 CD4 ART1 DEFA6;DEFA4;DEFA5 PRSS3;PRSS2;PRSS1 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation NANOG;NANOGP8 SOX2 POU5F1;POU5F1B OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins OPN5 RHO OPN1SW RRH OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RGR OPN4 OPN3 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism GNB1 GNB3 EXOC4 EXOC3 EXOC6 EXOC5 FSHB EXOC2 EXOC1 CMA1 ACE2 ACHE STX1A VAMP2 IGF1 POMC KLF4 GNAT3 CTSZ BCHE FFAR4 CTNNB1 PCSK2 PCSK1 ERO1B FFAR1 CPB2 KIF5C CGA SEC11A KIF5B TSHB SEC11C ANPEP KIF5A INS;INS-IGF2 CPA3 SLC30A8 MME MYO5A SLC30A5 ATP6AP2 GRP P4HB GZMH-1 CES1 ENPEP CPB1 CTSD GPR119 PLA2G7 CRHR2 CTSG ISL1 DPP4 CLTRN ACE AGT GIP CDX2 INHBB LEP MBOAT4 INHBC INHBE SPCS3 GATA4 SPCS2 CPE SPCS1 REN TCF7L2 PAX6 INHBA INHA RAB27A MYRIP GCG EXOC8 GNG13 EXOC7 LHB REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR RAN NUP88 RAE1 RCC1 NUP85 NDC1 NUP214 NUP37 RANBP1 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 XPO1 SEC13 NUP133 RANGAP1 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin IGF1 PLA2G7 KLF4 CRHR2 BCHE LEP MBOAT4 SPCS3 SPCS2 SPCS1 PCSK1 SEC11A SEC11C INS;INS-IGF2 GCG ACHE SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib SLC37A4 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD GCLC GCLM TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades TAB2 DUSP6 TAB1 DUSP7 TLR10 TLR5 LRRC14 USP14 PTPN4 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 OPTN-1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE UBE2D1 UNC93B1 TLR8 TLR7 CTSS TLR3 LGMN CTSB HSP90B1 MAP3K8 CTSK BTK ITGAM ITGB2 NFKB2 IRF7 PLCG2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 PPP2R1B MAPK14 PPP2R1A TLR6 TLR2 MAPK11 CD180 MAPKAPK3 IRAK1 LY86 MAPKAPK2 LBP BPI RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 SOCS1 ATF2 PTPN11 MAP2K7 CTSV;CTSL DNM1 MAP2K6 DNM3 LY96 PPP2CB;PPP2CA APOB PPP2R5D SLC15A4 MEF2C FGB FGA MAPK9 MAPK8 FGG TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 SIGIRR CUL1 S100A1 UBE2D3-1 CD36 RELA IRAK3 TIRAP RPS27A UBB;UBC NFKB1 TP53 NFKBIA DNM2 NFKBIB S100A9 S100A8 PIK3R4 TBK1 IRF3 CASP8 EEA1 TASL RBSN RIPK3 IRF5 RPS6KA5 TRAF2 TLR9 PIK3C3 PELI1 BIRC2 BIRC3 HMGB1-1 RIPK1 RIPK2 MYD88 FADD GSDMD ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 GSDME IKBIP DUSP4 MEF2A DUSP3 UBE2D3;UBE2D2 UBE2N IRAK4 VRK3 TAB3 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis AP2A1 AP2A2 GRK2 LDLRAP1 AP2M1 TGFA SH3GL3 SH3KBP1 STAM AP2S1 CBL HGS LDLR STAM2 EPS15 COPS5 SH3GL2 SH3GL1 DVL2 AP2B1 CLTC CLTA ITSN2 SCARB2 AGFG1 STON1-GTF2A1L GPS1 GRK3 CLTCL1 KIAA0319 TOR1A TOR1B SYT9 SYT8 SNAP91 DAB2 COPS4 IL7R PICALM COPS2 STON2 CD4 SLC2A8 SGIP1 EPS15L1 EPN1 EPN2 LRP2 FCHO1 FCHO2 REPS2 UBQLN1 UBQLN2 APOB NECAP2 NECAP1 SYT11 ARRB1 ARRB2 EGFR AGTR1 SYT2 SYT1 EGF UBA52 CFTR EREG AREG BTC VAMP2 EPGN HBEGF TFRC SLC18A3 CLTB AVPR2 AVP RPS27A UBB;UBC M6PR VAMP8 VAMP7 TACR1 WNT5A TF COPS7B COPS7A COPS3 COPS6 COPS8 TGOLN2 ITSN1 CHRM2 IGF2R FZD4 VAMP4 ADRB2 CD3G CD3D VAMP3 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells HRAS RASGRP1 RASGRP3 NRAS PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling TEAD1 TEAD2 JAK1 TEAD3 HLA-DPA1 TEAD4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FOS PDCD1LG2 H2AJ B3GNT3 CUL3 CSNK2A1;CSNK2A3 AGO3;AGO1 DERL3 DERL1 DERL2 OS9 SPOP BRD4 SUZ12 H2BC5 STAT1 STAT3 MIB2 H2BC1 FOSB VCP-1 TUSC3 NEK2 H2AC4 MYCN TMEM258 CD274 KMT2A KMT2C TCF7 SEL1L CCND1 CTNNB1 OST4 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 CDK4 GSK3B DPY30 H2BC21 WDR5 YWHAG EED H2AZ2;H2AZ1 DDOST DAD1 LCK IRF1 PRKAA1 PRKAA2 LEF1 HLA-DQB2;HLA-DQB1 RNF5 ERLEC1 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSK RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 TNRC6C CD4 H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 PDCD1 TNRC6B EP300 CREBBP PSMD8 NFE2L2 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 JUN PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 H2AC14 MYC PRKAB2 CSNK2A2 PRKAB1 CSNK2B ATF3 RPN2 EPAS1 RPN1 HIF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 WWTR1 JUND ERLIN1 ERLIN2 MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 HLA-DPB1-1 PRKAG1 PRKAG2 CD3G ASH2L MAGT1 CD3E CD3D PRKAG3 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation TFAM-1 TFB2M POLRMT ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis NCOR1 CNOT9 H2AJ PAXIP1 JUN SUZ12 RARG H2BC5 H2BC1 YY1 H2AC4 KMT2C RARB PBX1 KMT2D POLR2A POLR2B POLR2C DPY30 POLR2D POLR2E POLR2F PCGF2 POLR2G H2BC21 POLR2H WDR5 NCOA3 POLR2I EGR2 HOXA2 POLR2L EED H2AZ2;H2AZ1 RXRA POLR2J;POLR2J2;POLR2J3 KDM6A RARA H2AC14 CTCF RBBP4 PAGR1 RBBP5 HOXA3 HOXA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PKNOX1 HOXA4 PIAS2 RBBP7 HOXB3 HOXB2 HOXB1 AJUBA HOXD1 PAX6 HOXC4 MEIS1 HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MAFB HOXD4 HOXB4 HOXD3 ZNF335 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EP300 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L CNOT6 CREBBP NCOA6 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein NUP107 NUP43 RANBP2 NPM1-2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR RAN NUP88 RAE1 RCC1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 KPNB1 SEC13 NUP133 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ14 KCNJ2 KCNJ12;KCNJ18 KCNJ4 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism PITPNB MTMR4 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 TPTE;TPTE2 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 FIG4 PIKFYVE PNPLA6 PI4KB PTPN13 PIP4P1 ARF1 PI4K2B MTMR2 SACM1L PI4KA SBF1 PIK3CD PIK3CB PIK3CG PIK3CA PIK3R4 PIP5K1C INPP5E SYNJ2 PTEN OCRL PIK3C3 RAB5A PIK3R3 PIK3C2A PIK3R2 PIK3R1 PIK3R6 MTMR10 PIK3R5 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B INPPL1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 RAB14 SBF2 INPP5D INPP4A INPP5J RUFY1 INPP4B PIP4K2A PI4K2A PIP4K2B VAC14 MTMR1 MTMR3 SYNJ1 MTMR8 GDPD1 RAB4A MTMR9 GDPD3 GDPD5 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 JAK2 STAT5A STAT5B EPOR LYN EPO IRS2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol IPPK ITPK1 NUDT11;NUDT10-1 PPIP5K1 PPIP5K2 NUDT4;NUDT4B IP6K1 NUDT3 IP6K3 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes ATF4 EP300 MAFK NFE2L2 CREBBP SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP SMAD1 SMAD4 SMURF2 SMURF1 SKI SMAD6 SMAD7 UBE2D1 BMP2 ACVRL1 BMP10 BMPR2 AMHR2 CHRDL1 UBE2D3-1 FSTL1 AMH NOG GDF2 SMAD9 SMAD5 GREM2 ZFYVE16 BMPR1B BMPR1A INHBA ACVR2A TGFBR3 INHA ACVR2B CER1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling GGCT GGT7 GGT6 GCLC OPLAH CNDP2 GSS GGT1 GCLM GGT5 CHAC2 CHAC1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System RAC1 SLC38A1 SLC6A12 RPS6KA1 GLS2 ALDH2 ACTN2 GRIN2C SRC PPM1E PPM1F GRIN1 GRIN2D GRIN2A DLG2 CAMK4 NEFL CAMK1 NRAS MAPK1 HRAS MAPK3 PRKCA PLCB3 PDPK1 PLCB1 PLCB2 MAOA PRKAA1 PRKAA2 PRKAR1A MYO6 SYT9 CALM3;CALM1 SNAP25 SYT2 SYT1 STX1A VAMP2 SLC5A7 DBNL CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 GRIA2 CHRNA5 CHRNA4 GNGT1 CHRNA6 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD FLOT1 FLOT2 GIT1 GNG10 GNG2 GNG5 GNG4 GNG8 SLITRK3 SLITRK5 KCNG1 KCNG2 KCNG3 KCNG4 RTN3 KCNH1 KCNH2 KCNH3 KCNH4 GJD2 KCNH5 KCNK10 GJC1 PANX1 KCNH6 PANX2 KCNH7 GJA10 KCNH8 KCNK13 KCNK16 KCNK18-1 KCNK17 GNG13 KCNQ1 GNB2 KCNQ5 KCNV1 KCNV2 GNB1 SYT10 KCNMB2 GNB4 KCNMB3 SLC6A3 GNB3 KCNN1 GNB5 KCNMB4 KCNN3 KCNN4 KCNF1 KCNK9 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 AP2A1 KCND3 KCNAB1 KCNAB2 NTRK3 KCNAB3 KPNA2 KCNA10 HCN4 GAD1 HCN3 KCNA1 GAD2 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 GNAT3 HCN1 KCNK4 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 ABCC9 PRKAR2B CAMK2B CAMK2D CAMK2A SHARPIN CAMK2G KCNJ11 ADCY4 PRKAR2A GNAI3 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 RPS6KA3 GNAI2 RPS6KA2 ADCY5 MDM2-2 AKAP5 KCNMB1 KCNQ2 KCNQ4 KCNMA1 KCNN2 KCNQ3 GLS ABAT ARL6IP5 PRKCB GLUL GRIN2B UNC13B CACNA2D1 SLC6A13 CACNA2D3 CACNA2D2 SLC6A11 SLC22A2 SLC22A1 ACHE GRIP1 RPS6KA6 SLC6A1 SLC6A4 NSF PRKCG SLC18A2 SLC18A3 CASK SLC32A1 GRIP2 SYN3 GRIA1 SYN2 LIN7A SYN1 LIN7C ALDH5A1 LIN7B EPB41L1 SLC17A7 TSPAN7 BCHE RAB3A GRIA3 RIMS1 GRIA4 GRIN3B PPFIA1 PPFIA4 GNAL HOMER3 GRIN3A PPFIA3 EPB41 PPFIA2 NBEA STXBP1 GABRB3 CACNB1 EPB41L5 GABRB2 CACNB2 EPB41L2 GABRB1 CACNB3 HOMER1 CACNB4 HSPA8 RASGRF2 HOMER2 NAAA RASGRF1 PPFIBP1 KIF17 CHAT PPFIBP2 CACNA1B NRGN PTPRS GABRR3 CACNA1A PTPRF GABRR2 CPLX1 GABRR1 SIPA1L1 CACNA1E GABRG3;GABRG2 DLGAP1 LRTOMT DLGAP3 NPTN DNAJC5 DLGAP4 NRG1 TSPOAP1 BEGAIN HTR3A APBA3 HTR3B PICK1 APBA2 CAMKK1 LRRC4B CAMKK2 SYT7 GLRA1 LRFN3 COMT PTPRD CACNG8 GLRA2 LRFN2 GLRA3 LRFN4 KCNJ8 LRFN1 ABCC8 CACNG2 LRRTM3 CACNG3 LRRTM4 KCNJ2 LRRTM1 CACNG4 LRRTM2 KCNJ3 KCNJ12;KCNJ18 NRXN1;NRXN3;NRXN2 IL1RAPL2 KCNJ4 GABRA2 IL1RAPL1 GABRQ SHANK3 GABRA1 SHANK2 SHANK1 KCNJ5 GABBR2 NLGN3 GABBR1 NLGN1 NLGN2 KCNJ6 NRXN3 KCNJ10 GABRA6 NRXN2 GABRA5 SLITRK2 SLITRK1 KCNJ9 GABRA4 SLITRK4 GABRA3 SLITRK6 PRKAB2 PDLIM5 KCNJ15 NLGN4X;NLGN4Y KCNJ16 PRKAB1 SYT12 GLRB APBA1 KCNK6 KCNK7 KCNK1 GRM1 GRM5 SLC1A1 SLC1A2 SLC1A3 SLC1A6 PRKAG1 SLC1A7 PRKAG2 SLC38A2 PRKAG3 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose PLIN1 NR1H2 RXRB NR1H3 RXRA STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives GPX1 ALOX15 GPX4 ALOX12B ALOXE3 ALOX12 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape POLR2E POLR2F POLR1C H2BC21 POLR2H POLR1D RRN3 POLR2L GTF2H1 H2AZ2;H2AZ1 GTF2H3 UBTF GTF2H4 H2AJ CDK7 POLR1A ERCC3 POLR1B ERCC2 POLR1E POLR1F MNAT1 POLR1G POLR1H H2AC14 TAF1D TAF1B TAF1C TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 CBX3-1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 H2AC20 TBP H2AB2;H2AB3;H2AB1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle PLEKHG5 ARHGAP21 DDX4 ROCK1 RASAL2 WDR6 KTN1 FAM83B ANKRD26;CCDC144A;LOC105375816 VANGL1 FLOT2 DST CCDC88A PTPN13 VANGL2 UBXN11 SCRIB CPD DLG5 MUC13 PKP4 TNFAIP1 TMOD3 RND3 TXNL1 CKB SEMA4F PICALM CKAP4 PIK3R2 NISCH PIK3R1 KCTD13 ARHGAP5 ARHGAP35 RBMX CAV1 DSP LEMD3 DSG1 DEPDC1B EPHA2 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib CDC37 HSP90AA1 ERBIN ERBB2 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins FURIN PCSK6 PCSK5 NGF FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands FPR1 HEBP1 APP SAA2;SAA1 ANXA1 FPR2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAA2 PPARGC1A PRKAG1 PRKAB2 PRKAG2 MAPK14 PRKAB1 MAPK12 MAPK11 PRKAG3 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks UBE2I H2BC21 BARD1 MAPK8 BRCC3 TP53BP1 BABAM1 KDM4B RAD50 BABAM2 UIMC1 ABRAXAS1 UBE2V2 RNF8 SUMO1 RNF168-1 NSD2 ATM SMARCA5 MRE11 PPP5C BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 BAP1 UBXN1 H2BC5 UBA52 BAZ1B APBB1 NBN KDM4A H2BC1 EYA1 EYA2 CHEK2 EYA3 H2BC15;H2BC3;H2BC11;H2BC12 EYA4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ABL1 RPS27A UBB;UBC TP53 HERC2 MDC1 PIAS4 UBE2N LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHB DBT BCKDHA LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome WDR5 RBBP5 KMT2D ASH2L DPY30 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation FLT3 PTPN11 FLT3LG STAT5A STAT5B GAB2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle AURKB PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PTTG1;PTTG2 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 PLK1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CCNB1 CDC23 PSMD13 MAD2L1 CUL1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 NEK2 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 RB1 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 FBXO5 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 CDK2 BUB1B CDC20 CDC14A AURKA CCNA2-1 CCNA1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts NUP107 NCBP2-1 NUP43 SLBP EIF4E RANBP2 CPSF2-1 CPSF1 CPSF3 NUP205 NUP188 NXF1 WDR33 AAAS NUP42 NUP62 NUP160 TPR SYMPK NUP88 RAE1 ALYREF FIP1L1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 CPSF4 SEC13 NUP133 NCBP1 SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins IL25 TAB2 IL26 TAB1 CSF1 IL24 IL11 IL15 IL19 IL17RE RPS6KA1 OSMR IL17RB RHOU MAP3K3 IL33 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IL1RL2 PTK2B YWHAZ HSP90B1 POMC IL1RN CSF3 TNF IL12B IL12A IL10RB IL1R2 IL10RA CBL LIF TNFRSF1B TNFRSF1A FCER2 STAT6 CRKL MAP2K2;MAP2K1 STXBP2 MAPK1 MAPK3 GSTA3;GSTA5;GSTA1;GSTA2 MAPK14 LIFR RALA-1 MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK SHC1-1 SOCS1 ATF2 IL7R F13A1 CFL1 OPRM1 VIM IFNG HMOX1 MEF2C RAP1B JAK2 PPIA SNAP25 APP JUN FASLG SOD2 FOXO3 STX1A LMNB1 VAMP2 NOS2 RBX1 CISH SOCS2 HGF LCN2 TBK1 CASP8 CASP1 IL18 TRAF2 IL1A IL1B PELI1 HNRNPA2B1 IL17F IL17A HMGB1-1 GSDMD MMP9 HNRNPF HCK HSPA9 PRKACA-1 CDKN1A SNRPA1 CCND1 CEBPD BLNK JAK3 P4HB IL1R1 TYK2 CTSG IL17RC IL17RA SYK PPP2R1B PPP2R1A S1PR1 STAT2 TALDO1 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 MAP2K7 MAP2K6 IL23R PPP2CB;PPP2CA PITPNA SDC1 IL27 IL2RG IL27RA SERPINB2 INPPL1 AIP MIF LCP1 EBI3 INPP5D CNN2 IL6 HNRNPDL STAT4 CXCL8 PPP2R5D IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB BIRC5 CSF2RA IL5 IL3RA IL2RB MAPK9 MAPK8 MAPK7 MAPK10 PTPN18 IL37 PTPN20 PTPN23 PTPN13 PTPN14 IL18BP BCL2 SIGIRR PTPN9 BCL2L1 PTPN7 PTPN5 PTPN2 IL18R1 CD36 IRAK3 CASP3 MTAP IL4 IL18RAP CCL13;CCL2 IL13 ALOX5 PTGS2-2 TSLP IL7 RAG2 BRWD1 RAG1 CRLF2 MYC AKT1 SOD1 PIK3R3 PIK3R2 PIK3R1 HIF1A ALOX15 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN RIPK2 YES1 MYD88 ATF1 SAA2;SAA1 NKIRAS1 NKIRAS2 IKBIP DUSP4 IRF4 MEF2A DUSP3 IRAK4 VRK3 DUSP6 NANOG;NANOGP8 DUSP7 JAK1 LRRC14 USP14 NLRX1 PELI3 PELI2 FOS NLRC5 NOD1 IL34 NOD2 IL16 VAV1 IFNLR1 AGER IFNL2;IFNL3;IFNL1 IRAK2 S100A12 TXLNA PTPRZ1 N4BP1 STX3 TNIP2 USP18;USP41 IL6ST PAK2 STAT1 STAT3 CD86 CD80 MAP3K8 ICAM1 ITGAM ITGB2 NFKB2 IL10 TIFA ITGAX ALPK1 PIK3CD PIK3CB VCAM1 PIK3CA LCK GATA3 MAOA CDC42 FYN COL1A2 PTPN11 CD4 PTPN6 MMP2 ZEB1 CCR5 RORC TCP1 TP53 SOCS5 FPR1 SOCS3 CXCL2;CXCL3;CXCL1-1 CCL11 CCL4L2;CCL4L1;CCL4 CCL19 RPS6KA5 CCL22 CCL20 ITGB1 IL9 IL9R CA1 CCL3L1;CCL3L3;CCL3;CCL18 CXCL10 CCL5 IL2RA PTPN4 CCR1 CCR2 TEC OPRD1 SMARCA4 TGFB1 FOXO1-1 STAT5A STAT5B PIM1 GRB2 ANXA1 VEGFA RPLP0 ANXA2 POU2F1 HSP90AA1 PTPN12 CANX IRAK1 LBP SMAD2;SMAD3 IL2 STX4 IL3 SOS2 CAPZA1 TIMP1 MUC1 JUNB MSN PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ELK1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 SQSTM1 SOX2 RELA PSMA7 PSMB6 ARF1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 HSPA8 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 VAMP7 PSMC4 PSMC1 NFKBIB GSTO1 PTAFR RORA LAMA5 IRS1 CSF2 IL1RAPL1 IRS2 FGF2 FN1 GAB2 CSF1R CNTFR CNTF IL20RA MMP3 PSME2 IL20RB CSF3R IL22RA2 IL31RA IL22RA1 IL6R TOLLIP HAVCR2 CTF1 CLCF1 IL13RA2 IL13RA1 LGALS9C;LGALS9;LGALS9B FSCN1 NDN MCL1 TRAF6 IL21R IL36A IL36B UBE2V1 IL36G IL1F10 IL21 BCL6 IL22 UBE2N IL20 TAB3 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CUL3 PSMC2-1 PSMA5 KLHL12 PSMA6 PSMA3 HECW1 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 DVL1 PSMC3 PSMC4 DVL2 PSMC1 DVL3 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins NUP107 NUP43 RANBP2 NPM1-2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR RAN NUP88 RAE1 RCC1 NUP85 NDC1 NUP214 NUP37 RANBP1 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 KPNB1 XPO1 SEC13 NUP133 RANGAP1 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CTNNB1 EP300 LRRFIP1 CREBBP IRF3 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle RHOU LBR PTK2B WDR91 ANKFY1 WDR81 SH3RF1 CDC42SE2 ARHGAP9 OSBPL11 LRRC1 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 KCTD3-1 FGD5 CHN2 CHN1 FARP1 DEF6 WDR11 SRC CAV1 SHKBP1 FILIP1 STAM GOPC UHRF1BP1L FAM13B HGS FAM13A RALGAPA1 STAM2 TEX2 FAM91A1 ARMCX3 DDRGK1 NSFL1C ZNF512B VAV3 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 SH3BP1 WHAMM VAV2 GOLGA3 BAIAP2L2 STEAP3 SPATA13 KIDINS220 TMEM87A FAF2 FRS2 AKAP12 HINT2 ITSN2 SH3PXD2A CCDC115 RALBP1-1 RHOH HSP90AB1 RHOF ROCK1 RHOD ROCK2 RHOV GPS1 ACBD5-1 TWF1 EMC3 RAPGEF1 MSI2 PRAG1 RHOBTB1 SOS1 ARHGAP44 RHOBTB2 SYDE2 ACTG1 DOCK11 BASP1 TRA2B STK38 ARHGAP45 MYO6 ARHGAP19 RBBP6 ARHGAP18 TOR1AIP1 SPEN RNF20 ARHGAP12 SCFD1 ARHGAP22 CPSF7 ACTN1 ARHGAP20 TMOD3 ARHGAP29 TXNL1 MACO1 COPS4 ARHGAP28 CDC37 ARHGAP27 PICALM COPS2 ARHGAP25 ARHGAP24 PDE5A PHIP ARHGAP23 HNRNPC ARHGAP33 ARHGAP31 VIM DIAPH2 RBMX DBN1 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 PGRMC2 ARAP1 ALS2 PEAK1 CCDC187 MOSPD2 ARHGAP11A-1 ADD3 FAM169A FMNL1 FMNL2 TRIP10 IQGAP1 GRB7 KIF14 STMN2 MAP3K11 RND1 STIP1 LAMTOR1 WDR6 PLXNA1 FAM83B ANKRD26;CCDC144A;LOC105375816 DST RRAS2 ALDH3A2 TMEM59 CCDC88A FAM135A ACTC1;ACTG2 VANGL2 RTKN UBXN11 SOWAHC CPD ARHGEF10L AKAP13 DLG5 LMNB1 STK10 PKP4 SLK ARHGEF11 TFRC ARHGEF10 ARHGEF12 STARD8 ARHGEF17 CIT RHOB DAAM1 ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 PKN3 ARHGEF28 IQGAP3 ATP6AP1 STOM RHPN2 ECT2 STARD13 JUP CAVIN1 PCDH7 MYO9A NET1 ANLN DIAPH1 DLC1 PKN2 PKN1 HMOX2 ARHGEF40 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 RHOC TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 FGD1 NCKAP1 FGD2 WASF1-1 FGD3 NCF1 GNA13 FGD4 NCF2 SNAP23 NCF4 ARHGAP6 FLOT1 DOCK10 SYDE1 ARHGEF39 FLOT2 ARHGAP42 PLXNB1 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 ARAP3 CYBB OCRL CYBA BCR AMIGO2 NOXO1 DBT BCAP31 ARHGAP17 ARHGAP15 ABR RACGAP1 SLITRK3 NHS SLITRK5 NCKAP1L WASF2 GIT2 BAIAP2 ARHGAP26 ABI2 TAOK3 ABI1 NOXA1 NOX3 NOX1 FERMT2 C1QBP SAMM50 CUL3 RASAL2 MTX1 CYFIP2 WIPF1 WIPF2 WIPF3 PLXND1 WASL WAS WASF3 PREX2 WWP2 ARHGAP10 NUDC DOCK7 SENP1 DOCK3 FRS3 TIAM1 CPNE8 PTPN13 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CDC42BPB CDC42BPA SLC4A7 FMNL3 JAG1 DSP RASGRF2 DSG1 DSG2 TJP2 PIK3R3 PIK3R2 PIK3R1 SLC1A5 RAC1 FARP2 VAV1 ARHGAP39 SRGAP3 SRGAP2 SRGAP1 PAK1 PAK3 PAK2 VCP-1 PARD6B ABCD3 CCP110 CEP97 PIK3CA LCK CDC42 PLD2 CSK DDX4 USP9X GJA1 UACA CFTR CCT2 CCT7 CCT6A ACTB-1 ARHGEF18 RHOA PARD6A AAAS ARL13B ITGB1 CYFIP1 DOCK5 DOCK4 ANKLE2 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L STBD1 ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 EPHA2 VAMP3 RAB7A GARRE1 ARHGEF26 SHMT2 PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 STX5 YKT6 PAK4 NDUFA5 MCAM MCF2 ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 TPM4 CLTC TPM3 BUB1B-PAK6;PAK6 HSP90AA1 ABL2 NCK2 NCK1 SPTAN1 CAPZB MUC13 SOS2 PAK5 MYO9B MTMR1 SPTBN1 SRRM1 DDX39B MTR-1 TNFAIP1 RND3 CKB SEMA4F CKAP4 NISCH KCTD13 ZAP70 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance ALDOB MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A SGSH REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CANX DDOST POMT2 DAD1 SPCS3 SPCS2 CSNK2A1;CSNK2A3 PRKCSH SPCS1 POMT1 ARHGAP32 GANAB PIP5K1C CSNK2A2 CSNK2B RPN2 ANK3 RPN1 MOGS TMEM258 CDH1 CTNNB1 JUP OST4 FURIN PCSK6 SEC11A SEC11C OSTC STT3A PCSK7 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors GPR17 ADORA3 P2RY10 ADORA1 P2RY11 LPAR6 ADORA2B P2RY6 ADORA2A P2RY4 P2RY2 P2RY1 P2RY12 P2RY13 LPAR4 P2RY14 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes MDM2-2 IQSEC3 SYT10 MAPK1 CDK5 ARNT2 RBFOX3 MAPK3 ARNT CDK5R1 FOS GEM ARNTL XPO1 BDNF NPAS4 NAMPT PLK2 RET INS;INS-IGF2 CREBBP DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A2 MAN1C1 MAN1A1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids ACADL ECI1 ACADM DECR1 HADHA HADHB-1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization HBEGF PTK6 HIF1A EGFR GPNMB LRRK2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 SEM1 RHNO1 BLM WRN BRIP1 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs DENND1C DENND1B GDI1 DENND5B DENND1A RAB35 GDI2 RINL TRAPPC12 ULK1 TRAPPC11 RAB7B DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 DENND6B RIN3 YWHAE RAB38 DENND6A RIN1 RIN2 RAB21 ALS2CL CHML CCZ1;CCZ1B ANKRD27 DENND4B CHM DENND4A DENND4C HPS1 HPS4 RAB39A RAB39B TRAPPC8 RAB18 RAB3GAP2 MON1A RAB3GAP1 RAB3A MON1B SBF1 RAB27B TRAPPC2L TRAPPC2;TRAPPC2B GAPVD1 TRAPPC6A TRAPPC6B RAB3IP AKT2 RAB1A AKT3 AKT1 RAB1B RAB5B RAB5C RAB6A RAB5A RAB6B TRAPPC3 TRAPPC1 TRAPPC4 RIC1 TRAPPC10 TRAPPC5 TRAPPC9 RGP1 ALS2 RABGEF1 RAB9A RAB10 RAB14 SBF2 RAB13 RAB9B RAB27A RAB8A RAB8B RAB7A GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNB1 GNB4 GNB3 GNB5 GNAT3 ADCY9 GNAL GABRB3 GABRB2 GABRB1 GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 NPTN GNGT1 KCNJ2 KCNJ3 KCNJ12;KCNJ18 ADCY4 KCNJ4 GNAI3 GABRA2 GABRQ ADCY3 GABRA1 KCNJ5 ADCY2 GABBR2 ADCY1 GABBR1 ADCY8 KCNJ6 ADCY7 KCNJ10 GNAI1 GABRA6 ADCY6 GABRA5 GNAI2 KCNJ9 ADCY5 GABRA4 GABRA3 KCNJ15 KCNJ16 GNG10 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation DUSP6 TAB2 DUSP7 TAB1 MAPK9 MAPK8 MAPK7 RPS6KA1 IKBKB FOS NOD1 NOD2 IRAK2 IKBKG MAPK10 BTRC MAP3K7 SKP1 TNIP2 CHUK FBXW11 JUN ELK1 UBA52 CUL1 MAP3K8 RPS27A UBB;UBC NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 RPS6KA5 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 PPP2CB;PPP2CA RIPK2 ATF1 PPP2R5D TRAF6 UBE2V1 DUSP4 MEF2C MEF2A DUSP3 UBE2N VRK3 TAB3 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion TRMT10C PRORP TRNT1 HSD17B10 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSME1 PSMB2 PSME2 PSMB3 PSMB1 PSMB10 PSMB8 PSMA2-1 PSMB9 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction PIK3CB PDGFB HRAS GRB7 PIK3CA RASA1 PDGFRB RAPGEF1 SOS1 CRK NCK2 PLCG1 NCK1 STAT1 STAT3 PTPN11 PIK3R2 PIK3R1 SRC STAT5A STAT5B STAT6 CRKL PDGFRA BCAR1 NRAS SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS RALGDS HRAS NTRK1 MAPK14 RALA-1 NGF MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 SOS1 SHC1-1 SHC2 SHC3 RALB NRAS ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRB1 ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D ADRA1B ADRB3 ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes CCL13;CCL2 EP300 MAFK NFE2L2 CREBBP EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes H2AJ PAXIP1 H2BC5 LIPE H2BC1 DGAT2 ANGPTL4 H2AC4 LPL FABP4 RB1 KMT2A KMT2C PLIN1 LPIN1 MGLL DPY30 MED31-1 H2BC21 WDR5 NCOA3 NR5A2 H2AZ2;H2AZ1 CCNC-1 AGPAT2 PPARGC1B PAGR1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AJUBA HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MED16 MED17 MED12 MED14 MED13 MED10 EP300 ADIPOQ PPARGC1A NCOA1 MED27 MED1 NCOA2 CREBBP MED23 NCOA6 MED4 MED6 MED24 MED7 SIRT1 MED20 HCFC1 NCOR1 TBL1XR1 SETD1B SETD1A PLIN2 CDK5 CD36 KAT8 PHLDA1 BOD1L2;BOD1 NCOR2 ACSL1 KAT2B HCFC2 KAT2A WDR82 PEX11A BOD1L1 MBIP TASP1 DR1 CIDEC TADA2A GPS2 ZZZ3 KMT2D YEATS2 TADA3 AKAP8L SGF29 ELOVL5 KMT2B PHF20L1 PLIN4 GPAM KANSL1 SCD KANSL2 MED30 KANSL3 THRSP PNPLA2 CXXC1 RXRA MCRS1 KDM6A H2AC14 MEN1 PSIP1 ACSS3 PHF20 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CEBPA ABL1 OGT-1 H2AC20 H2AB2;H2AB3;H2AB1 PDK4 CDK8 ASH2L SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol CYP27A1 HSD3B7 AKR1D1 NCOA1 NR1H4 CYP7B1 NCOA2 CYP7A1 CYP8B1 RXRA ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 EPOR PLCG2 PLCG1 LYN EPO IRS2 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death HSP90AA1 TRADD CASP8 FLOT1 TNFSF10 FLOT2 PDCD6IP FASLG RIPK3 TRAF2 UBA52 PELI1 CDC37 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 RPS27A OGT-1 UBB;UBC MLKL FADD ITCH FAS STUB1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 PTPN4 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 OPTN-1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE UBE2D1 MAP3K8 BTK ITGAM ITGB2 NFKB2 IRF7 PLCG2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 PPP2R1B MAPK14 PPP2R1A TLR6 TLR2 MAPK11 CD180 MAPKAPK3 IRAK1 LY86 MAPKAPK2 LBP BPI RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 SOCS1 ATF2 PTPN11 MAP2K7 DNM1 MAP2K6 DNM3 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C FGB FGA MAPK9 MAPK8 FGG TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 SIGIRR CUL1 S100A1 UBE2D3-1 CD36 RELA IRAK3 TIRAP RPS27A UBB;UBC NFKB1 TP53 NFKBIA DNM2 NFKBIB S100A9 S100A8 TBK1 IRF3 CASP8 RIPK3 RPS6KA5 TRAF2 PELI1 BIRC2 BIRC3 HMGB1-1 RIPK1 RIPK2 MYD88 FADD ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2D3;UBE2D2 UBE2N IRAK4 VRK3 TAB3 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PPIA ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation CFD C3-1 CFB DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency TCN2 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway MAP2K2;MAP2K1 DUSP6 MAPK1 BRAP DUSP7 HRAS MAPK3 KSR1 BRAF PPP2R1B PPP2R1A RAF1 DUSP10 MAPK12 DUSP5 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PTPN3 PPP5C UBA52 PTPN7 MARK3 PPP2CB;PPP2CA DUSP16 PPP2R5E RPS27A UBB;UBC PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARAF PEBP1 DUSP4 YWHAB NRAS MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) TLR5 MYD88 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis ALAS2 ALAS1 ABCG2 FECH COX15 UROS CPOX PPOX ALAD UROD ALB HMBS COX10 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses STING1 CTR9 WDR61 RTF1 CDC73 HSP90AA1 LEO1 LOC110384692;C4A;C4B_2;C4B HSP90AB1 STAT2 UBR4 PAF1 IFIH1 VTN EXOC1 RBM10 MAVS TRIM25 IKBKE DDX3X-1 CLEC5A C1S MBL2-1 CGAS C4BPA C4BPB CLU APOA1 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance SOAT2 NPC2 CES3 PCSK9 AP2S1 AP2A1 AP2A2 LIPA LDLR NPC1-1 APOB LDLRAP1 AP2M1 AP2B1 NCEH1 LSR CLTC CLTA SOAT1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 VANGL2 UBA52 SCRIB PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 DVL2 PSMC1 WNT5A PARD6A SMURF2 SMURF1 PRICKLE1 FZD1 FZD3 FZD2 FZD5 FZD4 FZD7 FZD8 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression CSRP1 SNCB MTF1 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins UBE2I PCGF2 RNF2 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 SUMO1 DNMT3B DNMT3A BMI1 DNMT1 RING1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic PAFAH1B1 DYNC1I2 PLA2G6 DYNC1I1 DCTN1 DYNC1LI1 DYNC1H1 DYNC1LI2 DCTN2 AGPAT3 PLA2G4A DCTN3 GALNT2 CAPZB RAB6A DCTN6 RAB6B DCTN5 DCTN4 BICD1 RAB18 BICD2 RAB3GAP2 CAPZA3 CAPZA1 CAPZA2 ACTR10 RAB3GAP1 ACTR1A PAFAH1B3 PAFAH1B2 GALNT1 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development RPS6KA1 SIAH2 SIAH1 SOX10 HDAC2 POU3F2 SH3KBP1 SRC GRB10 MET SH3GL2 VAV3 SHC3 NRAS MAP2K2;MAP2K1 MAPK1 VAV2 HRAS MAPK3 FRS2 HSP90AB1 ROCK1 ROCK2 CLTCL1 SOS1 ACTG1 SHC1-1 PIP5K1C CFL1 ERBB2 ITGB3 PPP3CB GRB7 TLN1 RND1 PLXNA1 EIF4G1 ARHGEF11 CDK5 ARHGEF12 RHOB SREBF2 CDK5R1 ARHGEF28 RBX1 CYP51A1 RHOC DLG1 DLG3 ARHGEF7 DLG4 NGEF PLXNB1 GIT1 DPYSL4 SDCBP DPYSL5 DPYSL3 UNC5C UNC5D AGAP2 DSCAML1 PLXNC1 SEMA6A SEMA6D UTRN SEMA7A MMP9 RAP1GAP PLXNA2 COL4A2 MBP COL4A1 PLXNA3 PTPRC COL6A2 PTPRA RELN DAB1 PLXNB3 COL4A4 TREM2 VLDLR COL6A1 ADGRV1 SEMA3A COL4A3 NTN4 SEMA3E ABLIM1 COL9A1 PSENEN ABLIM2 PSEN2 ABLIM3 PSEN1 SEMA4A APH1A COL6A3 NCSTN ARTN COL4A5 APH1B PRX COL9A3 GFRA3 RGMB COL6A6 GFRA2 COL6A5 COL9A2 GFRA4 RASA1 RGMA DRP2 AP2A1 CD72 AP2A2 SCD5 MPZ NRTN DSCAM DOK1 DOK2 TYROBP AP2M1 DOK4 DOK5 NCAN DOK6 ADGRG6 SEMA4D CACNA1S PRNP LIMK2 PSPN LIMK1 RRAS HJV MYH14 CRMP1 MYH10 HMGCR PDLIM7 PMP22 PRKACA-1 PRKACB-1 AP2S1 PLXND1 AP2B1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1B ARPC1A WASL ACTR2 RPS6KA3 RPS6KA2 MYO10 SDC2 RPS27 PITPNA MAPK7 CLASP1 CLASP2 GAB1 GRIN2B GPC1 TIAM1 PLCG1 RPS6KA6 AGRN ADAM10 CSNK2A2 CSNK2B GFRA1 NEO1 PIK3R3 GDNF PIK3R2 PIK3R1 LYN WWTR1 YES1 RAC1 TEAD1 EPHA1 FARP2 ARHGAP39 CSNK2A1;CSNK2A3 SRGAP3 SLIT2 SRGAP2 SRGAP1 ROBO1 PAK1 PAK3 PAK2 GRIN1 MYH9 GSK3B PIK3CD PIK3CB EGR2 PRKCA PIK3CA CDC42 YAP1-1 FYN PTPN11 ELOC-1 EPHB6 EPHB1 ELOB EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 NCBP1 MMP2 EPHA3 EPHA10 EFNA5 EFNA4 EFNB2 EFNB1 EFNB3 EFNA1 EFNA3 EFNA2 NCBP2-1 EGFR MAG NAB1 NAB2 UNC5A UNC5B ACTB-1 CACNA1C RHOA RPS6KA5 ITGB1 TRIO ITSN1 ARHGAP35 ITGA5 RPL4 RPL30 RPL3 DOCK1 RPL32 EPHA2 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 KALRN RPS15 RPS14 RPS17 RPS16 PAK4 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 FES RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 SMARCA4 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 CACNA1H MYL12A RPL3L CACNA1G MYL12B RPS25 RPL5-1 RPS29 CACNA1I RPL27A RPS20 RPS21 MYH11 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 ITGAV CLTC CLTA PTK2 RPS4X RPL7A BUB1B-PAK6;PAK6 RPLP2 MSI1 RPL36-1 DAG1 HOXA2 MYL6 HSP90AA1 ISL1 PFN1 RPS3A CUL2 GSPT2 SEMA5A RPL13A-1 GSPT1 FLRT3 RPL11 PRKAR2A RPS27L RPS15A ABL2 RPL14 VASP RPS3 PABPC1;PABPC3 RPL13 CXCL12 NRP2 RPL12-1 LHX3 CNTNAP1 RPS2 LHX2 RPS6KA4 ALCAM RPL18 LHX4 SCN11A RPL17 LHX9 CHL1 RPL19 ROBO2 DPYSL2 RPL35A NRP1 RPL23A SCN9A USP33 NCK2 NRCAM RPL22L1 NCK1 SCN5A UPF2 EPHB2 FAU SPTAN1 CAP1 SCN1B DCC RPL26L1 SCN1A ENAH ETF1 KIF4B;KIF4A LYPLA2 EVL LDB1 PFN2-1 ANK2 SOS2 ANK3 ANK1 CXCR4 CACNA1D SPTB AKAP5 NTN1 DNM1 ZSWIM8 DNM3 SHTN1 SLIT1 GAP43 SLIT3 SCN10A PAK5 CAP2 SCN8A KCNQ2 MYO9B NUMB NELL2 DCX KCNQ3 SCN4A EZR SCN4B ITGA9 SPTBN4 SPTBN5 SPTA1 SCN7A NCAM1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX EIF4A3 MSN CASC3 RANBP9 L1CAM NFASC ITGA10 CNTN1 CNTN2 CD24 SCN2A SCN2B PSMD8 ST8SIA4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ST8SIA2 RBM8A PSMC2-1 PSMA5 PSMA6 RET PSMA3 PSMA4 PSMA1 UBA52 MAGOH;MAGOHB PSMD12 PSMD11 PSMD14 UPF3B PSMD13 RNPS1 PSMA7 PSMB6 PSMB7 PSMB4 CLTB PSMB5 POU3F1 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC CACNB1 ADRM1 CACNB2 CACNB3 PSMA2-1 CACNB4 HSPA8 SEM1 PSMC5 PSMC6 DNM2 PSMC3 PSMC4 PSMC1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 LAMA2 ITGA2B IRS2 SHANK3 LAMA1 LAMB1 LAMC1 GAB2 ITGA2 ITGA1 ABL1 PLXNA4 PRKCQ CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance POLD2 RPA1 RPA2 H2AJ RPA3 SMARCA5 H2BC5 H2BC1 DSCC1 RUVBL2 SHQ1 PIF1 CTC1 CHTF18 H2AC4 STN1 TEN1 DAXX ATRX CDK2 PPP6C H2BC21 PPP6R3 H2AZ2;H2AZ1 KNL1 NPM1-2 CENPN-2 CENPS-CORT;CORT;CENPS RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TINF2 RBBP7 ANKRD28 H2BC15;H2BC3;H2BC11;H2BC12 ACD LIG1 CCNA2-1 TERT TERF2 CCNA1 POT1 TERF2IP ITGB3BP CENPA CENPC HJURP RSF1 MIS18BP1 OIP5 CENPW CENPT CENPX MIS18A TERF1-1 CENPU CENPH CENPI CENPK CENPL CENPM CENPO CENPP CENPQ RUVBL1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L POLR2J;POLR2J2;POLR2J3 H2AC14 WRAP53 DKC1 NHP2 RFC5 RFC3 RFC4 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FEN1 RFC2 DNA2 H2AC20 RTEL1 BLM H2AB2;H2AB3;H2AB1 NOP10 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 WRN POLA2 POLD1 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways GNB1 GNB4 RAC1 GNB3 GNB5 VAV1 HCK ELMO1 CYFIP2 WIPF1 WIPF2 WIPF3 PYCARD AHCYL1 CYSLTR1 CYSLTR2 GNAT3 C3AR1 GGT1 ENTPD1 ENTPD5 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 BTK DPEP2 DPEP1 GNAZ MEFV NCKIPSD FCGR3A;FCGR3B PRKAR2B NFKB2 IL10 DVL1 CD163 PLCG2 PLK2 DVL2 RHBDF2 DVL3 VAV3 MYH9 NLRP3 ITPR1 GGT5 ITPR2 MYO5A ARPC4 ARPC5 ITPR3 PTK2 ARPC2 ARPC3 ACTR3-1 MAPK1 ARPC1B VAV2 ARPC1A WASL MAPK3 PSTPIP1 CTSG ACTR2 SYK FGR MAPK14 ADORA2B ADCY4 TXNIP PRKAR2A GNAI3 WAS HSP90AB1 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 CDC42 PRKAR1A CRK ADCY6 ACTG1 GNAI2 ADCY5 NT5E NCK1 FCGR1A FYN WASF3 MYO10 P2RX7 P2RX4 MYO1C SUGT1 TXN MYO9B HMOX1 IL6 FURIN MAPK8 CALM3;CALM1 JUN PLCG1 RELA ADAM17 NFKB1 GNGT1 WNT5A C3-1 GNAS-1 ACTB-1 NCKAP1 WASF1-1 CASP1 IL18 IL1A GNG10 IL1B CYFIP1 CYBA GNG2 GNG5 NOXO1 GNG4 GNG8 NCKAP1L LYN WASF2 ABL1 BAIAP2 YES1 ABI2 ABI1 NOXA1 GSDMD NOX1 FZD7 ELMO2 CD3G DOCK1 GNG13 GNB2 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN STING1 NLRP4 DTX4 DDX41 MRE11 PRKDC IFI16 XRCC6 TBK1 XRCC5 IRF3 TREX1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis F12 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFF HCRTR2 HCRTR1 QRFPR QRFP NPFFR2 NPFFR1 HCRT NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly NUP43 LBR TUBA1C TUBA1A TUBB1 LMNB1 RCC1 CCNB1 NUP37 TUBB2B;TUBB2A CDK1 KPNB1 TUBA4A TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 PPP2R2A;PPP2R2D UBE2I NUP107 TUBB4B PPP2R1A TUBB4A;TUBB;TUBB8B;TUBB8 SUMO1 TUBA8 NUP205 NUP188 NUP62 NUP160 RAN BANF1 CHMP4C CCNB2 NDC1 CHMP4B NUP85 ANKLE2 CHMP3 CHMP4A NUP155 CHMP6 NUP93 CHMP7 SPAST VPS4A CC2D1B SIRT2 POM121;POM121C IST1 NUP35 VRK1 NUP54 AHCTF1 LEMD2 PPP2CB;PPP2CA EMD SEC13 TNPO1 NUP133 LEMD3 CHMP2B CHMP2A RANGAP1 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing ADAR APOBEC1 APOBEC2 A1CF ADARB1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD ABCA1 APOA1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) POLD2 MSH2 MSH3 RPA1 PMS2 RPA2 MLH1 LIG1 RPA3 PCNA POLD3 POLD4 EXO1 POLD1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception TWF1 LRP2 APOB APOA1 CALM3;CALM1 SNAP25 STX1A VAMP2 GNGT1 CHRNA9 GNG13 GNB1 GNB3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW APOA2 APOA4 GNAT3 LPL OR11H4 OR4C13;OR4C46-2 OR2M4 OR6K3-1 OR4K17 OR1K1 LDLR OR1S1;OR1S2 OR4Q3 GPIHBP1 OR11H6 LRAT OR8G1;OR8G5 APOC3 OR11G2 OR1J4 OR1J2 OR4P4 FNTA OR1J1 APOC2 OR10AD1 OR6T1 RBP4 RBP2 ITPR3 RBP3 OR4K13 RBP1 OR7A10;OR7A17-11 OR51V1-1 RETSAT OR13J1 OR1I1 OR2K2 OR6S1 OR5M11 RDH12 ATP2B1 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 ADCY3 OR14K1 OR4N5 FNTB;CHURC1-FNTB OR5P3 OR5B17-3 OR10C1 LOC112268384;OR2A42;OR2A1 OR6C6-1 DHRS3 OR11L1 HSPG2 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 DHRS9 RDH11 OR52B6 OR5K3-3 SDC4 RDH10 OR1A1-1 SDC2 RIPOR2 OR1N2 MYO1C CLIC5 RDH5 OR1N1 SDC3 CIB2 OR6X1 PJVK EPS8 OR1E1;OR1E2 OR52K1-1 TPRN OR52A1 PLS1 TMC1 OR5L2;OR5L1-1 OR1M1 ESPN-1 OR4S2 MYO7A TMC2 OR5AC2-2 OR2AE1-2 MYO3B KCNMB1 OR10G2 MYO3A KCNMA1 OR14A16 KCNQ4 OR10G3 FSCN2 CHRNA10 OR8D2-1 PCDH15 KCNN2 OR7D4-5 USH1C SDC1 OR4K14-1 ESPNL OR5T1 CDH23 OR6V1 OTOG OR10G6 XIRP2 OR6C4-1 EPS8L2 GUCA1C MPP1 GRXCR1 OR10K1-1 GRXCR2 OR52W1 GSN OR5AS1 WHRN OR4F5;OR4F17;OR4F4 OR2T6 LHFPL5 OR13C9 OTOGL OR13C8 TMIE OR2T1 USH1G STRC OR4X1 OR2L13 MYO15A OR9A4 SLC26A5 OR51T1 PPEF1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 STRA6 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 RLBP1 OR2Y1 GPC1 OR8D4 OR8D1 OR56B4 GPC3 OR6C70 OR6C76 OR6C75 GPC2 OR6C74 GPC5 OR13G1 GPC4 OR13C3;OR13C4 OR4B1-2 GPC6 OR10A7 OR1L4;OR1L6-1 CASK AGRN OR6C1-1 OR10A4 OR56A4 OR56A3 OR10A3 EPB41L1 OR10A5 LRP1 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 LRP8 OR4X2-2 GNAL OR2W3 OR8B8 AWAT2 OR2W1 OR8B4 OR13F1 OR12D3 BCO2 BCO1 OR5AU1 RCVRN OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 OR52A5-2 OR2V2 OR8A1 OR11A1 METAP1 METAP2 OR10G9;OR10G7 OR8I2 OR9K2 OR52N1 OR52N5 OR52N4 KCNJ2 OR52N2 OR51L1 OR5D18 OR56B1-1 OR8B3;OR8B2-1 OR10W1 OR5B2 OR5D14 OR5D13 OR52M1 OR10V1 OR4C12 OR5A2 OR6C3 CLPS OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 PNLIP APOM OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 RPE65 OR4D11 OR2Z1 OR4D10 OR6A2 OR9G4 OR4E1 RDH8 OR8K5-1 OR51Q1 SLC24A1 OR2B6;OR2B2-1 OR4D9 SAG CNGA1 OR5AP2 RHO OR5B12 GNAT1 OR4D6 CNGB1 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 OR4C3 OR3A2 OR3A1 OR8K3 GUCY2D OR8K1 OR4C11-1 HSD17B6 OR2L3;OR2L8;OR2L2;OR2L5-1 HSD17B1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 SCNN1G OR2T2;OR2T35 OR6F1 SCNN1D OR51M1 SCNN1B OTOP1 SCNN1A OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 SDR9C7 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR1B1 OR2D2 OR52E4 OR5J2 CAMKMT RGS9BP OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 ANO2 GRK1 CALHM1 ABCA4 GRK7 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 CALHM3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 MYH9 LRP10 OR51A7 LRP12 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 EBF1 OR6Q1 OR52I1;OR52I2-1 OR11H1;OR11H12 OR4F21;OR4F16;OR4F29;OR4F3 PRKCA AKR1B15;AKR1B10 CYP4V2 OR9G9;OR9G1 PLCB2 OR7C1;OR7C2-9 OR51G2 OR51G1 PDE6B OR2H2 PDE6A OR1F1 OR4L1 OR5B3-13 OR10Q1 OR6P1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2B11 OR2AP1 OR4A47-3 OR51F2 OR2G6 OR5M9 OR51F1 OR4K5 OR4K3 OR4K2 OR5M3 OR4K1 OR10P1 LOC118142757;GUCA1A OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 CNGA2 NMT2 CNGA4 PLB1 NMT1 OPN1SW TAS2R3-1 TAS2R16 TAS2R40 TAS2R41 TAS2R39 APOE TTR TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PRH1-TAS2R14;TAS2R14-3 TAS2R7 TAS2R8 GRM4 TAS2R1 TAS2R4 TAS1R2 TAS1R1 TAS1R3 LHX2 SCN9A SPTAN1 SCN1B PCLO CAPZB BSN LDB1 SYP CABP2 CACNA1D CABP1 LRRC52 OTOF SLC17A8 CAPZA1 CAPZA2 EZR SCN4B SCN3A SPTBN1 RDX MSN SCN2A SCN2B CACNA2D2 SYN1 RAB3A CACNB2 TRPM5 TRPM4 DNAJC5 GRM1 PRKCQ TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation MBD3 RXRA SMAD1 SMAD4 PPARG GATAD2B GATAD2A PPARA HDAC2 RBBP4 PPARGC1B RBBP7 HDAC1 CHD4 CHD3 UCP1 HNRNPU MTA1 PRDM16 ZNF423 MTA3 ELOVL3 CIDEA EBF2 MTA2 BMP7 PPARGC1A NCOA1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway THRB NCOR1 PPARD VDR NR1H2 RORA ESR1 NR2C1 NR2C2AP NR4A2 NR5A1 AR RXRA NR1D2 RARA PPARG PGR PPARA ESR2 NR4A1 RARG NR2F1 NR0B2 NRBP1 NR2F6 THRA NR2E1 RORC RORB HNF4G HNF4A NR2C2 NCOR2 RARB ESRRA RXRB ESRRB ESRRG RXRG MED1 NR1D1 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) PTPN11 TLR4 LY96 RPS27A TBK1 UBB;UBC IRF3 OPTN-1 TICAM2 TICAM1 TANK IRF7 TRAF3 CD14 IKBKE UBA52 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis ACSBG1 SCD PPT2 SLC27A3 ACSBG2 SCD5 SLC27A2 ELOVL6 ELOVL3 HACD1 TECR HSD17B3 HSD17B12 HACD3 HSD17B8 ACSL1 HACD2 HACD4 ACACA MORC2 FASN CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 ACSL5 ACSL4 ACSL3 ELOVL7 TECRL ELOVL5 ACSF3 ACLY PPT1 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 RBBP8 BARD1 XRCC2 RMI2 PALB2 RMI1 TOP3A RAD50 RAD51 RAD51B RAD51D RAD51C ATM DNA2 BLM MRE11 BRCA1 RAD51AP1 BRCA2 KAT5 WRN BRIP1 EXO1 NBN ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI PLA2G10;LOC100652777 PLA2G2F PLA2G2D MBOAT7 PLA2G12A PLA2G2E PLA2G4D PLA2G4F PLA2G4E PLA2G1B PLA2R1 PLAAT3 PLA2G5 PLBD1 PLA2G2A-1 PLA2G4A CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia LIMD1 HIF1AN PSMD8 EGLN1 EGLN3 PSMD6 EGLN2 PSMD7 WTIP PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 VHL PSMA1 UBA52 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 UBE2D3-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC HIF3A ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 CITED2 PSMC1 VEGFA CUL2 EPO CA9 HIGD1A AJUBA EPAS1 HIF1A ARNT ELOC-1 ELOB EP300 CREBBP UBE2D3;UBE2D2 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 CHUK FBXW11 PSMC2-1 PSMA5 RELB PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBA3 UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 NFKB2 PSMC6 PSMC3 PSMC4 PSMC1 MAP3K14 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited CASP8 FADD TNFSF10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FAS FASLG TRAF2 RIPK1 TRADD RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle PLD1 KALRN ARHGAP21 LMAN1 STX5 YKT6 VAV1 MCAM ARHGAP39 MCF2 LBR ERBIN SRGAP1 KTN1 VANGL1 ARHGAP32 DIAPH3 VAPB ARHGAP9 ARHGAP4 GMIP ABCD3 FARP1 DEF6 CAV1 FAM13A TEX2 DDRGK1 VAV3 ARHGAP8;PRR5-ARHGAP8 TAGAP PLEKHG4 PLEKHG6 VAV2 TMEM87A FAF2 CCDC115 ROCK1 ROCK2 ACBD5-1 EMC3 ARHGAP44 ARHGAP45 ARHGAP19 ARHGAP18 ARHGAP22 SCFD1 ARHGAP20 ARHGAP29 PREX2 MACO1 ARHGAP28 ARHGAP24 ARHGAP23 ARHGAP31 ARHGAP10 ARHGAP30 MYO9B ARAP1 PGRMC2 ARHGAP11A-1 IQGAP1 TIAM1 ACTC1;ACTG2 RTKN SOWAHC ARHGEF10L AKAP13 STK10 SLK ARHGEF11 TFRC ARHGEF10 ARHGEF12 FMNL3 STARD8 ARHGEF17 CIT DAAM1 ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 PKN3 ARHGEF28 IQGAP3 ATP6AP1 STOM RHPN2 ECT2 STARD13 RASGRF2 JUP CAVIN1 PCDH7 MYO9A NET1 ANLN TJP2 DIAPH1 DLC1 PKN2 PKN1 ARHGEF40 HMOX2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF4 ARHGEF7 NGEF ARHGEF18 SNAP23 RHOA ARHGAP6 FLOT1 FLOT2 ARHGAP42 AAAS ARAP2 ARAP3 BCR TRIO BCAP31 PIK3R2 ABR ARHGAP1 PIK3R1 RACGAP1 ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L STBD1 ARHGDIB ARHGAP26 TMPO PLEKHG3 C1QBP DEPDC1B DOCK2 ARHGEF5 VAMP3 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants HBEGF CDC37 HRAS HSP90AA1 EGFR ERBIN ERBB2 NRG2 NRG3 SOS1 NRG4 SHC1-1 PLCG1 EGF NRG1 EREG BTC NRAS MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels FKBP5 PTPN4 OPRM1 SIN3A GPRIN1 GRIN2A GRIN2B MET OPRK1 HDAC2 GRIA2 PTPN1 TRPC3 HDAC1 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB THEM4 AKT2 PDPK1 TRIB3 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs PDGFRA SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol MTMR7 MIOX ISYNA1 INPP1 INPP5A IMPA1 IMPA2 INPP5B INPP4A INPP5J INPP4B SYNJ1 MTMR9 OCRL REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP CSF1 PENK PCSK9 PRKCSH MGAT4A-1 KTN1 MMP1 APOA2 SERPINC1 APOE APOA5 VCAN MFGE8 CST3 HSP90B1 ANO8 TNC ALB P4HB GZMH-1 FBN1 SERPINA1 CTSG DNAJC3-1 CALU F5 QSOX1 AHSG SPP2 SDC2 IGFBP7 APLP2 SCG3 TIMP1 IL6 APOB MMP2 PLG CDH2 APOA1 LTBP1 FGA FGG SPP1 KLK3;KLK2 DMP1 LGALS1 AMELY;AMELX EVA1A CCN1 APP CHGB IGFBP5 IGFBP4 GPC3 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS VGF SCG2 KLK1 IGF2 STC2 IGF1 IGFBP6 CHRDL1 AMBN FSTL1 FUCA2 TMEM132A BPIFB2 ADAM10 HRC MELTF MIA3 MSLN PRSS23 BMP15-1 MEPE RCN1 APOL3;APOL4;APOL1;APOL2 ENAM AMTN VWA1 FAM20C FAM20A MATN3 PAPPA2 ITIH2 MBTPS1 AFP FSTL3 SERPIND1 F2 GOLM1 KLK13 NUCB1 NOTUM PDIA6 PNPLA2 CP C3-1 LOC110384692;C4A;C4B_2;C4B TF LAMB2 FN1 LAMB1 WFS1 PROC LAMC1 MEN1 TGOLN2 FGF23 IGFBP1 IGFBP3 KNG1 BMP4 CKAP4 GAS6 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex POLR2E AQR ZNF830 POLR2F POLR2G PRPF19 POLR2H POLR2I POLR2L ERCC6 GTF2H1 TCEA1 XPA GTF2H3 COPS7B COPS7A GTF2H4 ERCC8 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 GPS1 COPS3 MNAT1 COPS6 ISY1;ISY1-RAB43 COPS8 USP7 UBA52 XAB2 DDB1 CUL4A COPS4 CUL4B COPS2 PPIE RPS27A UBB;UBC RBX1 COPS5 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D UVSSA ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 KPNA6 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KPNB1 H2AJ ORC5 ORC4 ORC6 ORC1 ORC3 H2AC20 ORC2 H2AC14 H2AB2;H2AB3;H2AB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 KPNA1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 E2F1 PPP2R3B PRIM2 TFDP1 PPP2R1B PPP2R1A PRIM1 RB1 POLA1 TFDP2 PPP2CB;PPP2CA POLA2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT AMER1 SOX9 H2AJ CUL3 CSNK2A1;CSNK2A3 TLE1 KLHL12 YWHAZ HECW1 H2BC5 HDAC1 H2BC1 SMARCA4 H2AC4 RUNX3 CAV1 TCF7 CTNNB1 DVL1 TLE4 DVL2 TLE2 DVL3 TLE3 GSK3B DPY30 H2BC21 WDR5 PPP2R1B H2AZ2;H2AZ1 PPP2R1A LEF1 SMURF2 RBBP5 SOX17 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TCF7L2 TCF7L1 TNKS TNKS2 H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 RNF146 PPP2CB;PPP2CA PPP2R5E XPO1 EP300 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TERT CREBBP PIP5K1B PSMD8 PSMD6 USP8 PSMD7 PSMD2 PSMD3 PSMD1 BTRC PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 AXIN2 PSMD14 APC PSMD13 SOX2 PSMA7 PSMB6 RSPO3 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RUVBL1 KMT2B TRRAP SOX3 FRAT2 WNT5A SOX6 CDC73 SOX7 SOX4 WNT9A RNF43 LEO1 RYK-1 CTNNBIP1 SOX13 CSNK1A1 DKK1 CTBP1 TPTEP2-CSNK1E;CSNK1E DKK2 DKK4 PYGO1 PYGO2 SFRP1 SFRP2 CSNK1G2 BCL9L H2AC14 BCL9 AKT2 CCDC88C MYC MEN1 CHD8 WNT8A USP34 WNT8B AKT1 CBY1 RSPO2 KAT5 CSNK2A2 SOST RSPO1 CSNK2B RSPO4 KREMEN1 KREMEN2 LRP5 LRP6 ZNRF3 WIF1 WNT1 SRY LGR6 LGR5 WNT3 LGR4 WNT4 FZD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 XIAP FZD2 FZD5 FZD4 WNT3A H2AC20 FZD6 H2AB2;H2AB3;H2AB1 FZD8 ASH2L SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells PIK3CD PIK3CB CSF1 THOC5 IL34 PIK3CA HCK SOS1 SHC1-1 GAB2 FYN UBA52 STAT1 STAT3 PTPN11 CSF1R PIK3R1 GRAP2 GAB3 LYN SRC RPS27A YES1 UBB;UBC KRAS INPPL1 CBL INPP5D PLCG2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling RAP1GAP2 SIPA1 RAF1 RASGRP1 PRKACA-1 PRKACB-1 YWHAZ RAP1GAP RAPGEF3 RAPGEF4 RASGRP2 YWHAB RAP1B RAP1A SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DPH5 DPH6 DPH7 EEF2 DNAJC24 DPH1 DPH2 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching ROBO1 ROBO2 SLIT1 NCK2 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway RAC1 VAV1 HSPB1 RASA1 ELMO1 CDH5 CALM3;CALM1 PRKCB PAK1 PTK2B RICTOR PRKCD PAK3 PAK2 PLCG1 CYFIP2 AHCYL1 SPHK1 CTNNA1 PRKACA-1 CAV1 CTNND1 PRKACB-1 THEM4 CTNNB1 JUP VAV3 SHC2 ITPR1 ITPR2 PRR5 ITGAV NRAS ITPR3 PTK2 PIK3CB VAV2 HRAS MLST8 HSP90AA1 PRKCA PDPK1 MAPK14 PIK3CA NCKAP1 MAPK12 WASF1-1 MAPK13 NCF1 MAPK11 NCF2 ROCK1 ROCK2 PRKCZ NCF4 RHOA MAPKAPK3 MAPKAPK2 CDC42 AKT2 CRK AKT3 NCK2 AKT1 NCK1 FYN WASF3 CYBB TRIB3 CYFIP1 CYBA MAPKAP1 MTOR AXL KDR PIK3R2 PIK3R1 NCKAP1L SHB WASF2 NOS3 BAIAP2 ABI2 ABI1 ITGB3 ELMO2 DOCK1 PXN BCAR1 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex SMARCA2 SMARCD3 SMARCA4 ACTB-1 BICRAL SMARCC1 BICRA SMARCC2 BCL7A BRD9 BCL7C BCL7B SS18 SMARCD1 SS18L1 SMARCD2 ACTL6A MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK HM13 NFE2L2 BACH1 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism GLYCTK KHK ALDH1A1 ALDOB TKFC MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation KIF22 HLA-DMA HLA-DMB RILP CD74 KIF26A HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 AP2A1 AP2A2 AP2M1 CTSS LGMN CTSB IFI30 CTSK AP2S1 KIFAP3 KIF5B SH3GL2 KIF5A HLA-DRA AP2B1 CLTC CLTA KIF3B CTSD KIF3A CTSC CANX KIF3C DYNC1LI1 DYNC1LI2 HLA-DQB2;HLA-DQB1 KIF4B;KIF4A CAPZB SEC31A CTSV;CTSL DNM1 DNM3 KIF18A CAPZA1 CAPZA2 ACTR1A SEC13 SPTBN2 KIF2A KIF2C KIF2B DYNC1I2 DYNC1I1 CTSA DYNC1H1 CENPE DCTN2 DCTN3 ARF1 SEC23A SAR1B DNM2 SEC24B SEC24A SEC24D-1 SEC24C DCTN1 AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 DCTN6 DCTN5 DCTN4 RACGAP1 CAPZA3 ACTR10 HLA-DOA HLA-DOB LAG3 KIF20A KLC1 KLC4 KLC3 KLC2 OSBPL1A HLA-DPB1-1 KIF11 KIF15 CTSO ACTR1B CTSH CTSF CTSE KIF23 RAB7A REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes LEF1 TLE1 TLE5 TLE4 TLE2 CTBP2 CTBP1 TCF7L2 TLE3 TCF7L1 HDAC1 TCF7 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ELOVL1 SCP2 ELOVL2 FADS2 ACOT8 ELOVL3 FADS1 ACAA1-1 HSD17B4 ABCD1 ELOVL5 ACSL1 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors RAC1 HCK CD8B;CD8B2 ELMO1 AP2A1 AP2A2 AP2M1 PAK2 KPNB1 AP2S1 AP2B1 NUP107 LCK CUL5 NPM1-2 FYN NUP160 RAN NUP85 CD4 CCNT1 ELOC-1 XPO1 ELOB SEC13 NUP133 RANGAP1 CDK9 PSMD8 NUP43 PSMD6 PSMD7 PSMD2 PPIA PSMD3 PSMD1 RANBP2 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 RCC1 PSMD14 PSMD13 NUP37 RANBP1 PSMA7 PSMB6 ARF1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ATP6V1H NUP205 NUP188 AP1G1 PSIP1 PACS1 AP1S2 AAAS AP1B1 NUP42 AP1S1 NUP62 AP1S3 TPR BANF1 B2M NUP88 AP1M2 AP1M1 RAE1 KPNA1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 CD28 DOCK2 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins LTA4H ALOX5 ALOX15 HPGD RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants NF1 HRAS SPRED3 SPRED2 SPRED1 NRAS EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation RPL34 EIF3F RPL10A EIF3D RPL8 EIF3A RPL9 EIF3B RPL6 RPL7 RPS15 RPS14 RPS17 EIF5 RPS16 EIF5B RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 EIF4EBP1 EIF4E EIF4B EIF4G1 UBA52 RPS27A EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M RPL4 EIF3K RPL30 EIF3L RPL3 EIF3I EIF3J RPL32 EIF3G EIF3H RPL31 EIF3E EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR RAN NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 XPO1 SEC13 NUP133 HSPA1A;HSPA1B TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors CACNG8 CAMK2G CACNG2 CACNG3 DLG1 PRKCA CACNG4 DLG4 AP2A1 PRKCB MYO6 GRIP1 NSF MDM2-2 PRKCG GRIP2 GRIA1 AKAP5 EPB41L1 TSPAN7 GRIA3 GRIA4 CAMK2B CAMK2D CAMK2A GRIA2 PICK1 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor VWF F8 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease RPIA TALDO1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 CUL1 UBE2S CDC26 CDC16 CDC27 PSMA7 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 CCNE2 CCNE1 CDK2 CDC6 GMNN CDT1 MCM7 ORC5 ORC4 ORC6 MCM3 ORC1 MCM8 MCM4 MCM5 ORC3 MCM6 ORC2 MCM2 CCNA2-1 CCNA1 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle EDEM1-1 CANX RNF139 UGGT2 UGGT1 MARCHF6 PRKCSH EDEM3 AMFR RNF103 DERL2 TRIM13 RNF5 OS9 PDIA3 GANAB UBA52 EDEM2 MAN1B1 SYVN1 RPS27A UBB;UBC SEL1L CALR-1 RNF185 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA EGF AREG MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2E DGCR8 POLR2F POLR2G POLR2H POLR2I POLR2L PRKRA DICER1 TARBP2 POLR2J;POLR2J2;POLR2J3 AGO3;AGO1 AGO4 BCDIN3D AGO2 XPO5 DROSHA RAN POLR2A POLR2B POLR2C POLR2D NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 NTRK2 DOCK3 RAC1 BDNF ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry VCP-1 CTSV;CTSL TMPRSS2 ACE2 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema F12 KLKB1 SERPING1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription CNOT2 CNOT3 RBBP8 ATRIP ZNF777 BARD1 ZNF775 CNOT8 CNOT9 RPA1 ZNF774 RPA2 ZNF426-1 ZNF772 ZNF771 ZNF770 SIN3B RAD50 SIN3A RAD51 RPA3 ZNF529 LBR ZNF75D RAD17 ZFP90 ZNF75A ATM RAD1 ZNF514 RAD9B ZNF750 RAD9A HDAC5 SMARCD1 ATR ANAPC15 HDAC2 ANAPC16 SMARCD2 ANAPC7 RNF34 UBE2C GLS2 NLRC4 UBE2E1 HDAC8 UBE2D1 HDAC9 ANAPC10 HDAC6 ANAPC11 HDAC7 CCNB1 ZNF746 CDC23 RFFL UBE2S ZNF740 CDC26 SMARCE1 CDC16 KCNIP3 CDC27 TXNRD1 CDK1 KLF4 ANAPC4 PML ANAPC5 TP53RK ANAPC1 HDAC10 ANAPC2 HDAC11 ZNF606 ZNF605 SRC RUNX3 ZNF839 ZNF555;ZNF57;ZNF556 ZFPM1 TWIST2 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 NUAK1 CTNNB1 TP53BP2 MET BANP GADD45A TPX2 CITED1 CITED2 CITED4 INS;INS-IGF2 PRMT6 YWHAB PRMT1 GP1BA COX7A2L-1 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 MAPK1 NPY ARNT2 STEAP3 MAPK3 LMO1 ZNF197;ZNF660-ZNF197 LMO2 KCTD1 MAPK14 ATP1B4 LIFR KCTD6 FANCD2 ZNF124-4 MAPK11 NOP2 COX7A2 NPM1-2 PMAIP1 SMAD1 SMAD4 CBX5 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 TP53I3 JMY KDM5B ATF2 THRA YBX1 NR2E1 SMARCD3 CASP6 CASP2 HDAC3 CTSV;CTSL AXIN1 OPRM1 ARID1A ARID1B RBL2 RBL1 ARNTL IFNG NR2C2 THBS1 HSPD1 XPO1 ERBB2 HES1 ZNF286A EP300 ZNF189 ZNF184 ZNF180 OPRK1 PPARGC1A ARID3A DEK MED1 MEF2C CREBBP NR1D1 SIRT1 NCOR1 TBL1XR1 CARM1 NFATC2 CALM3;CALM1 YWHAE JUN FASLG CDC25C SOD2 FOXO3 PRDX2 BCL2L11 CDK5 PRDX1 CDK5R1 NOTCH1 RBX1 IHH CRH FIP1L1 GAD1 GAD2 RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 SKP2 DAXX TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 PPP2R1B PPP2R1A CPSF2-1 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T WDR33 NUDT21 CLP1 PCF11 PAPOLA SYMPK PPP2CB;PPP2CA PPP2R5C BIRC5 AURKB MSH2 PMS2 MLH1 TJP1 OCLN-1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L RNGTT LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 H2AC14 AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A2 PRKAB1 CSNK2B MAPKAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 WWTR1 YES1 MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 TEAD4 FOS H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 RICTOR SUZ12 H2BC5 STAT1 H2BC1 H2AC4 KMT2A KMT2C TCF7 PRR5 GSK3B DPY30 H2BC21 WDR5 MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 PRKAA1 PRKAA2 LEF1 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B CCNK CCNT1 ELL GTF2B ELOC-1 TAF7L ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H TBP NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TP53 CPSF4 TGFB1 PARP1 PABPN1-1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 SOX2 ZNF521 TRPC3 PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA CPSF7 FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYB NFYC GPAM SP1 SRRT NFYA-1 CASP1 TP63 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CYCS-1 ITCH FAS BAX STUB1 PRKACA-1 CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 MDM2-2 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 AFF4 CBX4 MLLT1 CBX2 MLLT3 SUPT6H PHC3 IWS1 EAF1 EAF2 IL6 MDM4 BMI1 CCNA2-1 RING1 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PHAX SNRPD3 PRMT5 SNRPF SNRPB SNRPE-2 SNRPG-2 PHF20 CHEK2 ZNF385A PCBP4 GRIN2A CAMK4 PLK2 MDC1 SPI1 NOC2L RBPJ TGIF1-1 ZNF287 ZNF18 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 CLDN5 SCO2 DDIT3 DDIT4 TXNIP MEAF6 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 CCNC-1 SFN ZNF268 PPARGC1B PRELID3A ZNF263 ABCA6 NR2F1 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF496 CBX3-1 ZNF250 UCMA ZNF45 MED16 MED15 BBC3 MED17 MED12 MED14 MED13 HEY1 CASP10 MED10 HEY2 ZNF41 ZNF248 ZNF485 ZNF483 CNOT6L ACTL6B ACTL6A MED27 MED26 DDB2 SIRT3 MED23 MED25 MMP13 MED24 MED20 ZNF235 PPARD ZNF473 SERPINB13 ZNF470 HTT EGFR PLAGL1 SPP1 ZNF226 BID ZNF222 MBD3 USP9X ATAD2 CR1L;CR1 ZNF669;ZNF670 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 CENPJ SNAPC5 AGRP SNAPC1 ZNF215 SNAPC2 ZNF214 SNAPC3 ZNF213 SNAPC4 ZNF697 ZNF143 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 RORC RORB YY1 SESN3 SESN2 ZNF689 ZNF205 KMT5A ZNF688 ZNF446 ZNF445 PITX2 ZNF202 ZNF200 BNIP3L ZNF160;ZNF347;ZNF665-1 ZFP69B FOXP3 NPAS4 MAF PVALB ZNF432 KMT2D GRIA2 MAX DLX5 DLX6 KMT2B FOXO4 SOCS3 ATXN3 MED30 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 BCL2L14 SOCS4 ZKSCAN1 ZNF420 ZNF662 ZNF660 BRPF1 FBXO32 G6PC1 RGCC ZNF419 ZNF658 ZNF416 PIN1 SP7 ZNF655 TFAP2E;TFAP2B PPP1R13B COX4I1 COX4I2 PTEN ITGAL PPP1R13L ZNF649 DGCR8 YAF2 ZNF641 NKX3-2 TRIM63 ITGA4 APAF1 TNFRSF18 ARNT ZKSCAN7;ZNF852 RABGGTB RABGGTA RRM2B ZNF264;ZNF805-1 HAND2 ITGA5 SRF PPM1D TP53INP1 ZNF624 E2F5 ZNF621 E2F6 E2F7 E2F8 ZNF747;ZNF764 PTPN1 NDUFA4 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 ZNF613 PTPN4 TRIM33 SMARCB1 UXT LGALS3 TRIM28 EPC1 CCN2 SMARCC1 SMARCC2 ZFP1 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 L3MBTL2 NABP1-1 FOXG1 TGFA INTS1 ZNF707 INTS3 ZNF706 INTS2 ZNF704 INTS5 ZNF703 INTS4 HIVEP3 INTS7 APOE INTS6 PCK1 INTS9 CRADD INTS8 IQSEC3 INTS11 SMARCA2 INTS12 SMARCA4 INTS13 SNW1 INTS14 ITGBL1 INTS10 TP73 ICE1 COX7B ICE2 MSTN SSU72 HNF4G NABP2 COX7C ELL2 CTSK ELL3 HNF4A ZC3H8 COX8A RPRD2 SREBF1 RPAP2 PBRM1 RPRD1B COX8C RPRD1A FOXO1-1 POU2F2 BRPF3-1 SATB2 COX5B COX5A RXRB ZFP14 PERP RXRG COX6C GCK VEGFA TTC5 CCNG2 CCNG1 MED31-1 MAMLD1 POU2F1 ZFP28 PRDM1 COX6A1 COX6A2 ZNF274;ZNF74 NPPA ARID2 G6PD MSX2 COX6B2 GEM COX6B1 GPRIN1 ZNF354A;ZNF354B-4 SMYD2-1 NDRG1 IRAK1 SMAD2;SMAD3 ZNF324B;ZNF324 TFAP2A ZFHX3 TFAP2C TFAP2D AUTS2 CNOT10 IL2 IL3 BMP2 CNOT11 DYRK2 LDB1 CHD4 CHD3 PIDD1 YWHAQ MYBL2 RBM14 TGIF2 CAT TMEM219 RETN AURKA MTA2 ZNF804B REST KRAS ZNF175 MAML2 MAML1 SERPINE1 GLS SGK1-1 MYB NAMPT PIP4K2A PIP4K2B JUNB RNF111 GAMT PRDM7;PRDM9 MED8 MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 E2F4-1 ZNF394 NEDD4L LSM10 PSMD8 NKX2-5 SLBP NR2C2AP PSMD6 LSM11 PLK3 PSMD7 NFE2 PSMD2 PRELID1 PSMD3 ZNF383 PSMD1 ZNF382 ZNF140 SETD1B SETD1A CDC7 SKP1 NR1D2 PRKCB ZNF699-7 CDK12 CDK13 PSMC2-1 PSMA5 ZNF135 PSMA6 ZNF133 PSMA3 RET PSMA4 GPI PSMA1 BTG2 UBA52 RARG BTG1 PSMD12 SETD9 PSMD11 CHM PSMD14 ZNF568-3 PSMD13 GLI3 GLI2 CUL1 UBE2D3-1 RELA ING5 PSMA7 ING2 PIP4P1 PSMB6 AIFM2 PSMB7 RSPO3 PSMB4 TNKS1BP1 PSMB5 ZIK1 PSMB2 BRD2 PSMB3 BRD1 PSMB1 TCF12 RPS27A NCOR2 UBB;UBC KAT2B KAT2A ADRM1 NFKB1 TAL1 RARB PSMA2-1 ZNF599 SEM1 ZNF114 PSMC5 RRM2-1 PSMC6 ZNF597 PSMC3 ZNF112 PSMC4 GPS2 PSMC1 BRD7 ZIM2 ZNF584 ZNF583 WWOX TIGAR ZNF582 PCGF6 HDAC4 PCGF5 UBE2I PCGF2 WWP1 THRB VDR HIPK1 NR1H2 POU4F1 RORA POU4F2 NR3C1 HIPK2 RYBP ESR1 ZNF334 NR2C1 ZNF573 ZNF331 CSF2 NR4A2 NR5A1 ZNF570 AR ITGA2B RXRA YEATS4 SUMO1 ZFP30 ZNF569 ZNF567 RARA ZNF566 PPARG ZNF565 ZFP37 PGR PPARA ZNF563 MEN1 MRE11 IGFBP1 BRCA1 USP7 PF4;PF4V1-1 IGFBP3 KAT5 USP2 EXO1 ZNF302;ZNF181 NRBP1 CHEK1 KAT6A NBN ZNF317 ZNF311 TOPBP1 FKBP5 ZNF793 NOTCH2 CSF1R RFC5 RMI2 ZNF792 NOTCH3 RFC3 ZNF791 RFC4 NOTCH4 RMI1 KRBA1 ZNF549 RFC2 ZNF548 TOP3A HUS1 ABL1 ZNF304 ZNF546 ZNF786 RAD51D SKIL PLXNA4 DNA2 RHNO1 ZNF300 ESRRA BLM FANCI ZNF782 ESRRB PCNA ESRRG FANCC CNOT4 CDK8 WRN CNOT6 BRIP1 ZFP69 CNOT7 BCL6 CNOT1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly UQCRFS1 CYC1 UQCRC2 FXN HSPA9 SMIM4 UQCC3 LETM1 UQCRB UQCC2 UQCC1 UQCR11 HSCB UQCR10 BCS1L TTC19 LYRM4 UQCRQ LYRM7 UQCRC1 C12orf73 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation KDR HRAS AHCYL1 PRKCA PDPK1 SPHK1 RASA1 PRKCZ CALM3;CALM1 PRKCB PRKCD PLCG1 ITPR1 ITPR2 NRAS ITPR3 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR MC4R EDNRB RPS6KA1 EDN1 EDN3 PDE1C PDE1B PDE1A GRK2 PRKCD PLA2G4A MC3R POMC MC1R MC5R SRC CGA C5AR2 TSHB VAV3 C5AR1 NRAS MAPK1 VAV2 NPY HRAS MAPK3 ROCK1 ROCK2 GRK3 SOS1 OPRM1 OPRK1 ARRB1 ARRB2 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE PPP3CA DGKZ PPP3CB DGKQ DAGLB RASGRP1 DGKK PPP3R1 DGKI DGKH RXFP4 RLN3 CALM3;CALM1 RLN2;RLN1 INSL3 RXFP1 INSL5 APP RXFP2 RXFP3 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 CDK5 ARHGEF12 ARHGEF17 RHOB ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 ECT2 GLP1R VIPR1 WNT2B VIPR2 SCT NET1 IHH ADM FZD10 PTH1R ADGRE1 GNGT1 CRHBP ADRA1D SHH ADRA1B UCN3 ADRA1A ARHGEF40 ADGRE5 PLEKHG2 ADGRE3 ARHGEF15 GLP2R PLEKHG5 WNT5A WNT9B ARHGEF19 PTH2R RHOC WNT9A TIAM2 ARHGEF4 WNT16 ARHGEF7 GNAS-1 NGEF GIP ADCYAP1 ARHGEF6 FGD1 SMO FGD2 CRH FGD3 IAPP CALCA GNA13 FGD4 ADCYAP1R1 TBXA2R RAMP2 CALCRL GNA12 RAMP3 ARHGEF33 GIPR ARHGEF37 PTH ARHGEF39 DHH ARHGEF38 WNT8A PLXNB1 WNT8B CRHR1 PTHLH GHRHR WNT6 GNG10 WNT11 CALCR GNG2 GNG5 GNG4 GNG8 WNT1 ABR WNT2 CD55 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 CHRM2 FZD4 CHRM3 CHRM1 WNT3A CHRM4 PTCH1 CHRM5 CALCB;CALCA HTR2B GCGR WNT7B ADRB1 FZD7 ADRB2 FZD6 HTR2A HTR4 PTCH2 SCTR HRH1 HTR6 FZD9 HTR7 FZD8 WNT7A HRH3 GCG HRH2 GNG13 HRH4 DRD1 GNB2 ADM2 DRD2 DRD3 GHRH DRD4 GNB1 DRD5 GNB4 TAAR8 GNB3 HTR1E GNB5 HTR1F VIP TAAR9 RAMP1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRB3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CYSLTR1 AHCYL1 CYSLTR2 GNAT3 C3AR1 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 BTK GNAZ PRKAR2B CAMK2B CAMK2D CAMK2A ITPR1 ITPR2 ITPR3 CAMK2G PPP2R1B ADORA2B PPP2R1A S1PR1 ADCY4 GNAI3 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 CENPS-CORT;CORT;CENPS RPS6KA3 GNAI2 ADCY5 RPS6KA2 PPP3CC PPP2CB;PPP2CA CXCL8 PPP2R5D PLCB4 MAPK7 TIAM1 PRKCG OXTR AVPR1B AVPR2 AVP AVPR1A GNAL OXT-1 NBEA RASGRF2 CAMKK1 CAMKK2 CCL13;CCL2 C5 C3-1 GABBR2 GABBR1 AKT2 AKT3 AKT1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 RHO GNAT1 SAA2;SAA1 VAV1 PAK1 CAMK4 MCHR1 PIK3CG GNAT2 PRKCA PLCB3 PDPK1 PLCB1 PLCB2 PIK3CA CDC42 PRKAR1A SSTR3 EGFR RGS9 RGS6 RGS7 CCR5 GNA14 GNA15 MRGPRD GNA11 CMKLR1 PDYN AGTR2 FPR1 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 GPR37 GPR35 CXCL2;CXCL3;CXCL1-1 RGR GNAQ PLPPR1 ARHGEF18 CCL11 PLPPR2 PLPPR3 PLPPR4 RHOA RGS11 PLPPR5 CCL4L2;CCL4L1;CCL4 CCL19 OPN1SW GPHA2 CCL17 CCL16 CCL25 P2RY12 P2RY13 CCL22 CCL21 CX3CR1 CCL20 ITGB1 P2RY14 GPR55 CCL28 CCL27 TRIO GPHB5 ITSN1 CXCL13 ADORA3 ADORA1 LHCGR MTNR1A PREX1 MTNR1B CCL3L1;CCL3L3;CCL3;CCL18 PSAP CXCL10 MCF2L CXCL11 ECE1 PRLHR ADORA2A ITGA5 P2RY4 CCL5 ARHGEF16 CCL1 APLN ECE2;EEF1AKMT4-ECE2 RRH TAS2R3-1 CXCL5;CXCL6 PTGDR TAS2R16 GPR37L1 KEL TAS2R40 ARHGEF5 TAS2R41 TAS2R42 SST LHB NLN MC2R ARHGEF26 PENK PPY CCR10 KALRN CCR1 PPBP TAS2R39 HCAR2;HCAR3 ACKR3-2 PTGDR2 NPY4R2;NPY4R CX3CL1 MCF2 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 KPNA2 CCR2 OXGR1 FSHB GPBAR1 GAL FSHR OPRD1 PTGER4 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PPP1CA MAS1 XK NPY2R CCRL2 NPY1R PRH1-TAS2R14;TAS2R14-3 APLNR SUCNR1 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL9 TAS2R8 GRM3 MGLL HEBP1 GRM2 GRM4 GRM7 GRM6 ANXA1 GPER1 GRM8 TAS2R1 TAS2R4 PTGIR NPY5R SSTR1 SSTR2 SSTR4 GPR176 SSTR5 GPR15 CRHR2 OPRL1 GPR27 CNR2 GPR25 CNR1 GPR20 TAS1R2 GPR32 S1PR3 GPR45 TAS1R1 GPR150 S1PR2 PRKAR2A GPR83 S1PR5 GPR84 S1PR4 PDE2A TAS1R3 PPP1R1B TSHR CXCL12 PDE3A ACKR4 RGS8 ACKR2 PDE8B ACKR1 PDE8A PCP2 GRK6 PDE4D-1 GPSM1 GPSM2 PDE4A GPSM3 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A SOS2 RGS10 CXCR4 RGS12 PDE7B PDE7A NPFFR2 NPFFR1 RGSL1 GRPR EDNRA PROK2 PROK1 PRKCB UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 HBEGF NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 GAST FFAR2 FFAR1 GPR39 EDN2 TACR2 TRPC7 TACR3 TACR1 F2 TRPC6 TRPC3 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 ADRA2C GPR4 ADRA2B AGT ADRA2A F2RL1 F2RL2 F2RL3 PDE3B GPR68 GPR65 PMCH RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR F2R LTB4R2 NTS PF4;PF4V1-1 MCHR2 KNG1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR MMP3 RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK HCRTR2 HCRTR1 KISS1 FFAR3;GPR42 PRKCQ RASGRP2 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD MC2R POMC ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) SP1 SCD NFYA-1 TBL1XR1 DHCR7 CARM1 RXRA PPARA SMARCD3 TM7SF2 HMGCS1-1 GGPS1 CHD9 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 MVK HELZ2 ACACB TGS1 ACACA FASN PMVK SC5D FDFT1 FDPS NCOA1 MED1 NCOA2 NFYB NFYC CREBBP CYP51A1 NCOA6 SQLE GPAM NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects PNP-1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 CASP8 FADD CHUK DDX58 IFIH1 RNF135 IKBKB MAVS TRIM25 RIPK1 CASP10 IKBKG MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis SIRT1 MED7 MED20 NCOR1 TBL1XR1 H2AJ PAXIP1 PLIN2 H2BC5 LIPE H2BC1 DGAT2 CDK5 CD36 ANGPTL4 H2AC4 LPL FABP4 RB1 PHLDA1 NCOR2 ACSL1 KMT2C PEX11A PLIN1 LPIN1 MGLL CIDEC GPS2 KMT2D ELOVL5 DPY30 PLIN4 GPAM MED31-1 SCD MED30 H2BC21 THRSP WDR5 NCOA3 PNPLA2 NR5A2 H2AZ2;H2AZ1 RXRA KDM6A H2AC14 CCNC-1 AGPAT2 PAGR1 RBBP5 PPARGC1B ACSS3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AJUBA HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MED16 MED17 CEBPA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MED12 MED14 MED13 ABL1 MED10 EP300 H2AC20 H2AB2;H2AB3;H2AB1 ADIPOQ PPARGC1A NCOA1 MED27 MED1 PDK4 NCOA2 CDK8 ASH2L MED23 CREBBP NCOA6 MED4 MED6 MED24 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 QARS1 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RARS1 RPL35 RPL38 MARS1 RPS11 RPL39 RPS10 HNMT RPL15-1 DARS1 RPS13 RPS12 LARS1 RPS9 RPL21 RPS7 EEF1E1 RPS8 RPL23 KARS1 RPS5 RPL22 IARS1 RPS6 RPSA RPL24 TXNRD1 RPL27 AIMP1 RPL26 AIMP2 RPL29 RPL28 EPRS1 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 SEPHS2 SECISBP2 EEFSEC SEPSECS RPS27 PSTK INMT SARS1 GNMT SCLY PAPSS2 PAPSS1 UBA52 RPS27A CBS;CBSL AHCY NNMT CTH MAT1A RPL4 RPL30 RPL3 RPL32 RPL31 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX5 ALOX15 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway RPIA G6PD DERA TKT RBKS PGD SHPK RPE;RPEL1 PRPS2 PRPS1 TALDO1 PGM2 PGLS CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL3 DERL1 DERL2 RNF5 OS9 ERLEC1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CFTR PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ERLIN1 ADRM1 ERLIN2 SEL1L PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RNF185 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts NR1H4 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FABP6 SLCO1A2 STARD5 RXRA ABCC3 SLC10A1 SLC10A2 SLC51A ABCB11 SLC51B SLC27A5 NCOA1 NCOA2 ALB BAAT SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants MAP2K2;MAP2K1 JAK2 MAPK1 BRAP FGB HRAS CAMK2G FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B MAP3K11 VCL FN1 CALM3;CALM1 CSK MARK3 SRC KRAS CAMK2B CAMK2D ITGB3 CAMK2A ARAF PEBP1 ARRB1 YWHAB PHB IQGAP1 ARRB2 NRAS RAP1B RAP1A VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability RAC1 VAV2 MLST8 HSP90AA1 PDPK1 VAV1 CDH5 CALM3;CALM1 PAK1 AKT2 RICTOR AKT3 PAK3 AKT1 PAK2 TRIB3 MAPKAP1 MTOR CTNNA1 NOS3 CAV1 CTNND1 THEM4 CTNNB1 JUP VAV3 PRR5 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 CHUK FBXW11 PSMC2-1 PSMA5 RELB PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBA3 UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 NFKB2 PSMC6 PSMC3 PSMC4 PSMC1 MAP3K14 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle GARRE1 RAC1 PLD1 IQGAP2 KALRN ARHGAP21 YKT6 FARP2 PAK4 VAV1 MCAM ARHGAP39 MCF2 SRGAP3 LBR ERBIN SRGAP2 MPP7 SRGAP1 KTN1 VANGL1 PAK1 ARHGAP32 DIAPH3 PAK3 ESYT1 PAK2 ARHGAP9 CYFIP2 ARHGAP4 WIPF1 GMIP WIPF2 WIPF3 CDC42EP4 FGD5 CHN2 CHN1 FARP1 DEF6 CAV1 FAM13B FAM13A VAV3 TAGAP PLEKHG4 PLEKHG1 PLEKHG6 SH3BP1 BUB1B-PAK6;PAK6 VAV2 WASL SPATA13 PIK3CA RALBP1-1 ABL2 WAS ARHGAP44 SOS1 CDC42 SYDE2 DOCK11 ARHGAP45 PLD2 WASF3 ARHGAP12 ARHGAP22 ARHGAP20 ARHGAP29 PREX2 SOS2 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP31 ARHGAP10 PAK5 ARHGAP30 MYO9B DOCK6 DOCK9 ARAP1 ALS2 FMNL1 DOCK7 IQGAP1 LAMTOR1 DOCK3 TIAM1 DOCK8 ARHGEF11 CDC42BPA TFRC ARHGEF10 CIT JAG1 ARHGEF25 IQGAP3 ECT2 RASGRF2 DLC1 PKN2 PKN1 PLEKHG2 ARHGEF15 ARHGEF19 TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 NCKAP1 WASF1-1 ARHGEF18 NCF1 GNA13 NCF2 SNAP23 NCF4 PARD6A DOCK10 ARHGEF39 ARHGAP42 BAIAP2L1 GIT1 SWAP70 ARAP2 ARAP3 CYBB ITGB1 CYFIP1 CYBA BCR DOCK5 DOCK4 AMIGO2 NOXO1 TRIO ARHGAP17 PIK3R3 ARHGAP15 NISCH PIK3R2 ABR ARHGAP1 PIK3R1 RACGAP1 ARHGAP5 ARHGAP35 NHS PREX1 OPHN1 NCKAP1L ARHGDIA WASF2 MCF2L GIT2 BAIAP2 ARHGDIB ARHGAP26 EMD ABI2 TMPO TAOK3 PLEKHG3 ABI1 NOXA1 NOX3 VRK2 SLC1A5 NOX1 LEMD3 FERMT2 DEPDC1B CDC42EP1 DOCK2 DOCK1 ARHGEF5 EPHA2 VAMP3 RAB7A DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition PPP1R12A OPTN-1 AKAP9-1 FBXL7 PLK1 PKMYT1 PPP1CB CCNB1 CDK1 NEK2 CCP110 PRKACA-1 CDKN1A CEP250 FZR1 CDK5RAP2 CEP135 CSNK1D PRKAR2B TPX2 CDK2 PPP2R2A;PPP2R2D HSP90AA1 YWHAG CEP70 FOXM1 PPP2R1B CEP72 PPP2R1A CEP192 SGO1 CEP76 HSP90AB1 CEP78 PLK4 ODF2 RBBP4 CCNB2 AJUBA CEP57 CETN2 CEP164 MYBL2 ACTR1A AURKA PPP2CB;PPP2CA MAPRE1-1 CNTRL XPO1 EP300 CDK11A;CDK11B PPME1 BORA CEP290 OBI1 RAB8A LCMT1 CCNA2-1 TICRR CKAP5 CCNA1 HAUS4 GTSE1 PAFAH1B1 FKBPL HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 PSMD8 HJURP HAUS2 PSMD6 HAUS1 PSMD7 MIS18BP1 PSMD2 CLASP1 PSMD3 PSMD1 BTRC DYNC1H1 SKP1 NDE1 CEP63 CENPF FBXW11 YWHAE PSMC2-1 PSMA5 TUBA1A PSMA6 DCTN2 PSMA3 SSNA1 CENPJ CDC25C PSMA4 DCTN3 PSMA1 UBA52 CDC25A PSMD12 HAUS8 FBXL18 CDC25B PSMD11 HAUS7 PSMD14 PSMD13 PCNT CUL1 OFD1-1 CEP152 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 NEDD1 PSMB2 TUBA4A PSMB3 ALMS1 PHLDA1 PSMB1 RPS27A UBB;UBC ADRM1 CEP41 RBX1 PSMA2-1 CEP43 TP53 SEM1 PSMC5 PSMC6 PPP2R3B PSMC3 PSMC4 TUBGCP2 HMMR PSMC1 MZT2A;MZT2B CCNH TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 TUBG2 NME7 MZT1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CDK7 MNAT1 LIN54 LIN52 LIN37 LIN9 WEE1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs SNRPG-2 SNRPD3 ZNF473 NCBP2-1 NCBP1 LSM10 LSM11 SNRPF SNRPB SNRPE-2 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins RAC1 SRGAP2 DIAPH3 PLK1 DVL1 DVL2 DVL3 ERCC6L NUP107 ZWILCH BUB1B PMF1;PMF1-BGLAP CDC20 PFN1 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 RHOD CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CDC42 CENPS-CORT;CORT;CENPS ACTG1 MIS12-1 CDCA8 NUP160 SKA1 SKA2 DSN1 EVL NUP85 PFN2-1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D FMNL1 PPP2R5C FMNL2 RANGAP1 SCAI CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B MRTFA ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 FMNL3 RHOB DAAM1 DIAPH1 RHOC ACTB-1 RHOA ITGB1 SRF APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 CDC20 ANAPC5 ANAPC1 ANAPC2 RPS27A UBB;UBC ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBA52 UBE2D1 ANAPC10 ANAPC11 CCNB1 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors PTS COQ5 GCHFR HPDL COQ3 HSP90AA1 COQ2 PRKG2 SPR PDSS2 PDSS1 COQ8A NOS3 ACO1 CALM3;CALM1 DHFR2;DHFR AKT1 GCH1 STARD7 COQ9 COQ7 IDH1 COQ6 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis MAPK1 RNF213-2 MAPK3 VPS33B ENO1 CTSG CORO1A PGK1 TLR2 UBA52 MRC1 B2M LTF KPNA1 TRIM27 RAB5A KPNB1 NOS2 DUSP16 RPS27A SFPQ-1 UBB;UBC HGS GSK3A ATP6V1H RAB7A PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation KCNH2 AKAP9-1 KCNE2 KCNA5 KCNE3 KCNE4 KCNE5 KCNQ1 KCNE1;KCNE1B SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion SEMA3A RAC1 CFL1 HSP90AA1 HSP90AB1 PLXNA1 PLXNA4 PAK1 NRP1 PAK3 PLXNA2 PAK2 FES FYN PLXNA3 LIMK1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation FGF4 FGF9 FGF20 FGF23 FGF16 FGF18 GALNT3 FGF1 FGF2 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors RAC1 PPP1R14A PPP1R12A PPP1R12B YWHAH H2AJ SRGAP2 PAK1 PRKCD PAK3 YWHAZ PAK2 PLK1 H2BC5 H2BC1 H2AC4 GOPC CDH1 CTNNB1 MYH9 YWHAB MAPK1 H2BC21 MAPK3 YWHAG PRKCA PDPK1 H2AZ2;H2AZ1 MAPK14 MAPK11 RHOD ROCK1 ROCK2 CDC42 SFN ACTG1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CFL1 H2BC15;H2BC3;H2BC11;H2BC12 CTTN XPO1 FMNL1 FMNL2 NCOA2 IQGAP1 KIF14 KDM4C-1 KLK3;KLK2 CALM3;CALM1 YWHAE CDC25C RTKN CFTR CIT RHOB DAAM1 PKN3 IQGAP3 RHPN2 DIAPH1 PKN2 PKN1 RHOC S100A9 S100A8 DLG4 ACTB-1 NCKAP1 WASF1-1 NCF1 NCF2 PRKCZ RHOA NCF4 PIN1 CYBB ITGB1 CYFIP1 CYBA NOXO1 NCKAP1L WASF2 BAIAP2 ABI2 ABI1 SRF NOXA1 NOX3 RHOG NOX1 KLC1 KLC4 KLC3 KLC2 IQGAP2 KTN1 DIAPH3 LIMK2 LIMK1 PPP1CB MYH14 CYFIP2 MYH10 WIPF1 FLNA WIPF2 WIPF3 CTNNA1 BTK CDKN1B MYL12B MYLK NCKIPSD DVL1 KIF5B DVL2 MYH11 KIF5A DVL3 KDM1A ARPC4 ARPC5 PTK2 ARPC2 ARPC3 ERCC6L ACTR3-1 NUP107 ARPC1B ARPC1A ZWILCH WASL BUB1B MYL6 PMF1;PMF1-BGLAP CDC20 PFN1 ACTR2 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 WAS SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 NCK1 WASF3 NUP160 SKA1 SKA2 DSN1 EVL NUP85 PFN2-1 RCC2 NDC80 YWHAQ ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SCAI CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B MRTFA ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 TAX1BP3 DYNC1H1 CENPU NF2 NDE1 ROPN1;ROPN1B CENPE PRC1 PRKCB CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 FMNL3 LIN7B PIK3R4 AR H2AC14 MEN1 PIK3C3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ABL1 H2AC20 H2AB2;H2AB3;H2AB1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism ELOVL1 SCP2 ELOVL2 FADS2 ACOT8 ELOVL3 FADS1 ACAA1-1 HSD17B4 ABCD1 ELOVL5 ACSL1 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation TGFBR3 MMP14 MMP16 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B TIMP2 TIMP1 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP9 PPP1CA FABP1 PPP1CC FABP2 FABP3 FABP4 FABP5 CAV1 PRKACA-1 FABP6 PRKACB-1 FABP7 GPD2 PLIN3 PNPLA4 PNPLA5 PLIN1 MGLL ABHD5 FABP12 PPP1CB LIPE CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) NCF4 CD36 ITGB5 CYBB ITGAV NCF1 CYBA NCF2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling DNM1 NTRK1 DNM3 NGF AP2S1 AP2A1 AP2A2 DNM2 SH3GL2 AP2M1 AP2B1 DNAL4 CLTC CLTA NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors UBE2I KCTD15 TFAP2A TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B WWOX SUMO1 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors FOS H2AJ AGO3;AGO1 ADH4 H2BC5 ADH1C;ADH1B;ADH1A HDAC1 H2BC1 FOSB H2AC4 CAV1 SRC CITED1 ABCG8 ABCG5 PRMT1 NRAS MAPK1 HRAS H2BC21 MAPK3 PDPK1 H2AZ2;H2AZ1 KCTD6 PIK3CA HSP90AB1 GATA3 STRN ESR2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ATF2 TNRC6A-1 TNRC6C HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 TNRC6B CCNT1 XPO1 NRIP1 EP300 TBP MMP2 GTF2A1 NCOA1 GTF2A2 MED1 NCOA2 CREBBP NCOR1 PPARD TBL1XR1 CDK9 CARM1 EGFR CALM3;CALM1 JUN FOXO3 YY1 SPHK1 DHRS4 KDM3A KDM1B APOD ARL4C EEPD1 GNGT1 GPAM SP1 SCD PRKCZ GNG10 IGF1R GNG2 GNG5 GNG4 DLD GNG8 NOS3 SRF PDHB MMP9 PDK4 PDK3 GNG13 GNB2 DLAT GNB1 PDK2 GNB4 PDK1 GNB3 PDHX GNB5 PDHA1 KPNA2 TGFA PPP5C MYLIP APOE PCK1 KDM4A ANGPTL3 ABCG1 GNAT3 CETP FABP5 FABP6 CDKN1B PLIN1 CCND1 ABCA1 RXRB APOC4 RXRG NR1H3 FOXA1 APOC2 KDM1A TLE3 APOC1 FKBP4 PTK2 DDX5 POU2F1 GREB1 CHD1 CTSD NCOA3 SMC3 NR5A2 HSP90AA1 TFF1 KANK1 PTGES3-1 CXXC5 S1PR3 TFF3-1 KDM4B GNAI3 USF2 USF1 ZNF217 EBAG9 CXCL12 CRABP1 GNAI1 DHRS3 GNAI2 SDR16C5 CYP26A1 ALDH1A3 CYP26B1 DHRS9 RDH11 ALDH1A2 RDH10 RDH5 RDH14 RDH13 RAD21 CBFB ALDH8A1 RUNX1 STAG1 STAG2 FASN MYB SMC1A ZDHHC7 CRABP2 ZDHHC21 PPID CAV2 MMP7 EGF ELK1 RARG BCL2 UHMK1 EREG AREG BTC EPGN HBEGF NCOR2 KAT2B RARB GPS2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H NR1H2 POLR2I POLR2L ESR1 GTF2F1 GTF2F2 RXRA POLR2J;POLR2J2;POLR2J3 RARA H2AC14 PGR AKT2 MYC AKT3 AKT1 KAT5 FKBP5 PIK3R3 PIK3R2 PIK3R1 ALDH1A1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MMP3 JUND MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation FGFR1 PIK3CA FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 TRIM24 GAB2 STAT1 STAT3 BCR PIK3R1 CUX1 BAG4 FGFR1OP2 MYO18A CPSF6 ERLIN2 CEP43 STAT5A LRRFIP1 STAT5B ZMYM2 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A RAD51B RAD51D RAD51C DNA2 SEM1 RTEL1 BLM RAD51AP1 WRN BRIP1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL4A3 COL4A6 COL20A1 COL9A1 COL8A2 COL8A1 COL6A3 COL4A5 COL21A1 COL9A3 COL6A6 COL6A5 COL9A2 COLGALT2 BMP1 PLOD3 TLL2 PLOD2 TLL1 PLOD1 COLGALT1 P3H2 P3H1 PCOLCE P3H3 PCOLCE2 SERPINH1 CRTAP P4HA1 P4HA2 P4HA3 P4HB ADAMTS2 ADAMTS3 COL1A1 COL1A2 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL12A1 COL11A2 COL19A1 COL10A1 PPIB COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 ADAMTS14 COL3A1 COL2A1 COL5A1 COL4A2 COL4A1 COL7A1 COL6A2 COL5A3 COL4A4 COL6A1 COL5A2 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection RAC1 PAK2 XRCC6 XRCC5 LCK CUL5 NPM1-2 FYN CD4 TSG101 VPS4B VPS4A MVB12B CCNK MVB12A CCNT1 ELL VTA1 GTF2B VPS37C ELOC-1 VPS37D TAF7L VPS37A ELOA XPO1 ELOB VPS37B NELFB UBAP1 NMT2 NELFA VPS28 NELFCD NELFE CHMP5 SUPT16H TBP FURIN NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 PPIA TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 RCC1 NMT1 CCR5 RANBP1 RBX1 ATP6V1H NUP205 NUP188 PSIP1 PDCD6IP AAAS NUP42 NUP62 TPR BANF1 NUP88 RAE1 CHMP4C KPNA1 NDC1 CHMP4B NUP214 CHMP3 NUP210 CHMP4A NUP155 NUP153 CHMP6 NUP93 CHMP7 NUP50 POM121;POM121C NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 CHMP2B CHMP2A DOCK2 HCK CD8B;CD8B2 ELMO1 AP2A1 AP2A2 LIG4 XRCC4 AP2M1 KPNB1 AP2S1 AP2B1 NUP107 NUP160 RAN NUP85 CXCR4 LIG1 SEC13 NUP133 RANGAP1 NEDD4L PSMD8 NUP43 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RANBP2 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 NUP37 PSMA7 PSMB6 ARF1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 B2M AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E FEN1 CD28 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants ALK IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID CHUK IKBKB IKBKG NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation NTRK2 NTRK1 ADCYAP1 ADCYAP1R1 ADORA2A FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling PTPN11 HRAS FRS2 KLB FGF1 FGF2 FGF4 FGF6 FGF9 SOS1 FRS3 FGF20 FGF23 FGF16 FGF19 FGF18 NRAS FGFR4 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1-1 ACAT1 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism DTYMK NME4-1 AK1 AK2 TXNRD1 CDA GLRX GDA AK5 PFAS AK6 DNPH1 AK7 ATIC AK8 PPAT ENTPD1 AK9 TK2 ENTPD5 AK4-1 NUDT13 ADSL ENTPD2 GMPR2 RRM1 ADK ENTPD3 CTPS2 ENTPD4 AMPD1 NME3 CAD CTPS1 GMPR ENTPD6 AMPD2 DCTD ENTPD7 AMPD3 NME6 TK1 ENTPD8 DCK CMPK1 NT5C1B;NT5C1B-RDH14 APRT DCTPP1 RRM2-1 ADAL UMPS TYMS GART DGUOK PNP-1 NT5C2 PAICS ADA UCKL1 DHODH UCK1 PUDP NME2 ADSS1 GMPS ADSS2 ITPA NME1 IMPDH1 GUK1 IMPDH2 HPRT1 NUDT15 NT5C XDH AGXT2 NT5C1A DPYS DPYD NT5M UPP1 UPB1 TYMP NT5E SAMHD1 TXN RRM2B NUDT16 NUDT5 ADPRM CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 MLST8 RPS3A DDIT3 RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ATF2 MTOR RPS27 SEC13 RPTOR CEBPB RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 UBA52 TCIRG1 SESN2 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 RPS27A ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V1G3 ATP6V1D C12orf66 ATF4 SZT2 ATP6V1C1 SEH1L ATP6V1C2 NPRL2 NPRL3 ATP6V1F GCN1 WDR59 EIF2AK4 FLCN MIOS ATP6V0E2;ATP6V0E1 ITFG2 IMPACT DEPDC5 CEBPG KPTN WDR24 SH3BP4 FNIP1 FNIP2 CASTOR1 CASTOR2 ASNS BMT2 TRIB3 ATF3 EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPL4 RPL30 RPL3 RPL32 RPL31 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TLR4 LY96 RIPK1 TRADD CASP8 FADD TNFSF10 TICAM2 TICAM1 FAS FASLG CD14 TRAF2 RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling MAMLD1 SNW1 JAG1 RUNX3 KAT2B KAT2A NOTCH1 MAML2 HES1 MAML1 EP300 CREBBP RBPJ HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly A2M ZDHHC8 ABCA1 PRKACA-1 PRKACB-1 APOA1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism GALNS B3GNT7 B3GNT4 B3GNT2 CHST1 OGN B3GNT3 CHST2 B4GALT2 B4GALT3 B4GALT1 CHST3 OMD HEXB HEXA ST3GAL4 GLB1L3 ST3GAL1 SLC35D2 GLB1L2 ST3GAL2 ST3GAL3 GNS GLB1L GLB1 FMOD ST3GAL6 B4GALT6 B4GAT1 KERA B4GALT4 B4GALT5 PRELP ACAN LUM CHST6 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification FASTKD2 RPUSD4 RPUSD3 TRUB2 SLIRP RCC1L NGRN MTPAP TRMT61B LRPPRC MTERF3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins LTA4H ALOX5 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds AKR1A1 GGT7 GGT6 MGST3 MGST1 MGST2 TPST2 GLYATL3 ACSM5 TPST1 GLYAT ACSM4 GSTK1 CYP1A2 GGT1 GSTT1 OPLAH CNDP2 HPGDS N6AMT1 ESD MTRR TPMT CHAC2 GGT5 ACSM1 CHAC1 AHCY NNMT ACSM2A;ACSM2B GSTM4 GSTO1 GSTM3 MTR-1 GSTO2 GSTM1;GSTM2-1 MAT1A GSTT2B;GSTT2 GSTA3;GSTA1 MAT2B GGCT COMT GSTZ1 UXS1 TRMT112 GSTA4 AS3MT MAT2A GCLC GSTA3;GSTA5;GSTA1;GSTA2 GSS GCLM GSTP1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABHD10 UGT2A1 SLC35D2 UGT1A1;UGT1A6 UGDH SULT1C2 SLC35D1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 NAT1 BPNT2-1 PODXL2 ABHD14B BPNT1 SULT6B1 SULT2A1-4 SULT4A1 SULT1B1-1 UGP2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR1-1 TGFBR2 TGFB1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation DMRT1 SRY FGF9 AMH PTGDS DHH ZFPM2 WT1 SOX9 NR5A1 GATA4 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template POLD2 RPA1 RPA2 POLE4 NPLOC4 RCHY1 RPA3 POLE2 POLE3 UBA7 TRIM25 UBA52 UFD1 POLK POLE VCP-1 POLH RFC5 USP10 RFC3 REV3L RFC4 PCLAF RFC1 POLI USP43 RFC2 REV1 MAD2L2 RPS27A SPRTN UBB;UBC ISG15 UBE2L6 PCNA POLD3 POLD4 POLD1 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin HBEGF TXNRD1 EEF2 HSP90AA1 CD9 HSP90AB1 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants FLT3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi MAN1A2 MAN1C1 MAN1A1 MGAT1 MANEA INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway IL36RN IL1RL2 IL36A IL36B IL36G IL1F10 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria PAH SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC CSNK2A1;CSNK2A3 LPCAT1 CSNK2A2 CSNK2B ACHE BCHE SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PCTP CEPT1 MFSD2A PCYT1B CHKB LPIN1 CHAT PCYT1A LPIN2 CHKA LPIN3 STARD10 ABHD3-2 PHOSPHO1 PEMT CHPT1 STARD7 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation FGF3 FGF7 FGFBP1 FGF22 FGFBP3 FGF1 FGF2 FGF10 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL3 DERL1 DERL2 OS9 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CD274 PSMB1 RPS27A UBB;UBC ADRM1 SEL1L PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RNF185 PRKAA1 PRKAA2 RNF5 ERLEC1 PRKAB2 PRKAB1 ERLIN1 ERLIN2 PRKAG1 PRKAG2 PRKAG3 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion PPIA BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) LTC4S GSTM4 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 PRKCG WNT5A PRKCA CLTB FZD4 AP2S1 AP2A1 AP2A2 PRKCB AP2M1 DVL2 AP2B1 CLTC ARRB2 CLTA REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 HIVEP3 STAT1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 DLX5 DLX6 GSK3B WWP1 NR3C1 ESR1 MSX2 SMURF1 PPARGC1B BMP2 CBFB NKX3-2 ESRRA PPARGC1A STUB1 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion HGS RAB5A VPS33B CORO1A UBA52 RPS27A UBB;UBC RAB7A NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR NRP2 KDR NRP1 FLT1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation NMT1 NMT2 CALM3;CALM1 HSP90AA1 ZDHHC21 SPR AKT1 NOS3 DDAH1 CAV1 LYPLA1-1 CYGB TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling SPPL2A TAB2 SMPD3 TAB1 SMPD2 CLIP3 TAX1BP1 NSMAF OTULIN ULK1 RBCK1 IKBKB IKBKG MAP3K7 CHUK OPTN-1 IKBKE UBA52 UBE2D1 MIB2 UBE2D3-1 BAG4 TNF ADAM17 RPS27A UBB;UBC TNFRSF1A RNF31 OTUD7B SPATA2 TNFAIP3 SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 TBK1 TRADD CASP8 MAPKAPK2 TRAF2 USP2 BIRC2 BIRC3 XIAP RIPK1 FADD STUB1 UBE2D3;UBE2D2 SPPL2B RACK1 TAB3 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing GOLGA7-1 HRAS ZDHHC9 PRKG2 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ICMT ABHD17C ABHD17B ABHD17A RCE1 KRAS FNTB;CHURC1-FNTB CALM3;CALM1 ARL2 PRKCQ FNTA PDE6D LYPLA1-1 NRAS BCL2L1 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) NCOR1 RNF2 TBL1XR1 FOS KLF13 MBD3 BATF IL4R SATB1 NFATC2 HDAC5 GATAD2B GATAD2A HDAC2 JUN HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 SMARCA4 SNW1 MTA1 YY1 MTA3 HDAC10 HDAC11 NCOR2 KMT2A KAT2B KAT2A NOTCH1 POU2F2 STAT5A STAT5B MAF STAT6 DPY30 RBPJ HDAC4 IL4 POU2F1 MAMLD1 IL13 WDR5 GATA3 ETS1 MEN1 RBBP4 RBBP5 RBBP7 CHD4 CHD3 NOTCH2 HDAC3 CBX8 CBX6 PHC2 PHC1 MTA2 CBX4 CBX2 PHC3 MAML2 MAML1 EP300 BMI1 ASH2L RING1 IRF4 CREBBP IL5 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation FGF23 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed SUMO3 SUMO2 SENP5 SENP2 SENP1 SUMO1 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport TTPA FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes KLF4 MSTN PCBP4 RBL2 CAV1 CDKN1A CDKN1B FOXO1-1 SMAD2;SMAD3 SMAD4 GADD45A FOXG1 FOXO3 BTG1 CCNG2 FOXO4 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation EARS2 QARS1 RARS2 AARS2 PARS2 MARS2 DARS2 YARS2 HARS2 FARS2 WARS2 LARS2 GARS1 SARS2 PPA2 NARS2 TARS2 IARS2 VARS2 KARS1 CARS2 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency EIF2S3;EIF2S3B ATF4 CEBPB EIF2AK1 EIF2S1 ATF5 DDIT3 CEBPG GRB10 ASNS PPP1R15A CHAC1 TRIB3 ATF3 EIF2S2 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay SRRT NCBP2-1 C1D EXOSC10 TENT4A MTREX PABPN1-1 RBM27 DIS3 MPHOSPH6 ZCCHC8 ZCCHC7 EXOSC7 RBM26 EXOSC6 YTHDC1 EXOSC5 ZC3H4 EXOSC4 ZC3H3 EXOSC9 YTHDC2 TENT4B EXOSC8 PAPOLG EXOSC3 XRN2 ZC3H18 EXOSC2 RBM7 EXOSC1 ZFC3H1 WDR82 DXO NCBP1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization PGF KDR FLT4 FLT1 VEGFA VEGFB VEGFC VEGFD PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL PTPN11 PTPN6 MAPK14 FGR PPP2R1B PPP2R1A PPP2CB;PPP2CA LRP8 PPP2R5E PPP2R5B PPP2R5A APOB PPP2R5D PECAM1 PPP2R5C PLA2G4A REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2BC21 ZCCHC8 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPHOSPH8 H2AJ RBM7 MORC2 EHMT2 PPHLN1 H2AC20 EHMT1 TASOR H2AC14 H2AB2;H2AB3;H2AB1 ATF7IP SETDB1 MTREX H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins FGB FGA VWF FGG APBB1IP SRC TLN1 ITGA2B FN1 CRK ITGB3 BCAR1 PTK2 RAP1B RAP1A INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination RBBP8 H2BC21 RPA1 RPA2 H2AZ2;H2AZ1 RAD50 H2AJ RAD51 RPA3 ATM H2AC14 MRE11 BRCA1 BRCA2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 NBN H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 MLH1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 TOP3A RAD51C H2AC20 BLM SPO11 C1orf112 PSMC3IP H2AB2;H2AB3;H2AB1 MND1 MLH3 MSH4 DMC1 MSH5 PRDM7;PRDM9 CDK4 FIGNL1 CDK2 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CDK5 CLOCK ARNTL CSNK2B CSNK2A1;CSNK2A3 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin MAPK1 MAPK3 INHBB INHBA ACVR2A TGFBR3 SMAD2;SMAD3 SMAD4 INHA ACVR1C FSTL3 ACVR1B FST FOXH1 ACVR2B DRAP1 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing CLTRN CPE EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 STX1A VAMP2 PCSK2 PCSK1 ERO1B KIF5C KIF5B RAB27A MYRIP KIF5A INS;INS-IGF2 SLC30A8 EXOC8 MYO5A SLC30A5 P4HB EXOC7 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR2B HTR1E HTR1F HTR2A HTR4 HTR1D HTR6 HTR1A HTR7 HTR1B HTR5A DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System PRL TGFA EGF AREG FGF10 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans COL9A1 ITGB6 TGFB3 ITGA8 COL9A3 COL9A2 DMP1 NCAN BGN DCN BCAN VCAN AGRN FMOD ITGB5 TGFB1 SPARC TNC MATN3 PTPRS COMP IBSP ITGAX ITGAV HAPLN1 TNN TNR MUSK ASPN MATN1 DAG1 MATN4 TNXB LRP4 DSPP LAMA5 LAMA2 LAMB2 ITGA2B LAMA1 LAMA4 LAMA3 LAMB1 LAMC1 VTN HSPG2 ITGB1 ITGA2 ITGA7 TGFB2 ITGA9 SERPINE1 ACAN NCAM1 ITGB3 LUM SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC6A19 SLC32A1 SLC6A3 SLC6A15 SLC6A5 SLC6A14 SLC17A8 SLC17A7 SLC6A2 SLC6A7 SLC6A9 SLC17A6 SLC6A20 SLC6A13 SLC6A11 SLC25A18 SLC22A2 SLC22A1 SLC6A1 SLC25A22 SLC6A4 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation SH3PXD2A ADAM15 ADAM12 ADAM19 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 HRAS KLB FGF1 FGF2 FGF4 FGF6 FGF9 SOS1 FGF20 FGF23 FGF16 FGF19 FGF18 NRAS FGFR4 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones DDX11 EDEM1-1 WIPI1 PDIA6 PDIA5 ERN1 ACADVL DNAJC3-1 CTDSP2 KDELR3 DCTN1 TLN1 CXXC1 EXTL1 CUL7 SSR1 DNAJB9 KLHDC3 ZBTB17 PREB WFS1 EXTL2 GFPT1 YIF1A SHC1-1 SRPRA HDGF TPP1 GOSR2 EXTL3 HSPA5 JMJD7-PLA2G4B;PLA2G4B SEC31A LMNA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARFGAP1 DNAJB11 SYVN1 ATP6V0D1 ADD1 PPP2R5B SRPRB-1 FKBP14 HYOU1 MYDGF GSK3A TATDN2 TSPYL2 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI RFC5 RFC3 RPA1 RFC4 RPA2 REV3L RFC1 POLI RFC2 REV1 MAD2L2 RPA3 RPS27A UBB;UBC PCNA UBA52 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 MAPK3 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ UBTF H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MBD2 H2BC5 H2BC1 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers RAC1 SALL4 VAV1 IL33 CSNK2A1;CSNK2A3 AGO3;AGO1 PDE1C PDE1B HDAC5 IL1RL1 PDE1A RICTOR GRK2 HDAC2 PRKCD SUZ12 KIT HDAC1 HDAC7 FLT3LG CD86 CD80 MTA1 PML MTA3 SNAI2 NEDD4 SRC INSR CAMK4 THEM4 MET EGR1 INS;INS-IGF2 GSK3A PRR5 GSK3B PIK3CD PIK3CB MAPK1 PIK3CG PDGFB CD19 MAPK3 MLST8 PRKCA EED FRS2 PDPK1 PIK3CA IER3 LCK PHLPP2 PHLPP1 ATN1 MAF1 RPS6KB2 PRKAR1A RBBP4 PIP5K1C STRN ESR2 NR4A1 FYN RBBP7 ATF2 TNRC6A-1 PTPN11 NR2E1 MTOR TNRC6C HDAC3 TNRC6B MKRN1 ERBB2 NRG2 NRG3 NRG4 RPTOR TSC2 RRAGA RRAGC RRAGB RRAGD EGFR AKT1S1 PRKCE SLC38A9 MBD3 RHEB LAMTOR2 LAMTOR1 LAMTOR4 CALM3;CALM1 LAMTOR3 LAMTOR5 GATAD2B GATAD2A JUN FOXO3 TP53 FOXO4 HGF PTEN XIAP RHOG STUB1 PDGFRA PDGFRB TRAT1 NTRK3 PIK3AP1 KPNA2 TGFA AHCYL1 ADCY9 PRKACA-1 PRKAR1B CDKN1A PRKACB-1 CDKN1B FOXO1-1 SNAI1 PRKAR2B CAMK2B CAMK2D CAMK2A ITPR1 KDM1A ITPR2 ITPR3 FLT3 CAMK2G PPP2R1B PPP2R1A ADCY4 PRKAR2A ADCY3 RCOR1 PRKX ADCY2 ADCY1 IRAK1 ADCY8 ADCY7 ADCY6 ADCY5 PREX2 MDM2-2 CHD4 TRIM27 CHD3 USP13 TNKS TNKS2 WWP2 RNF146 CBX8 FRK CBX6 PHC2 OTUD3 PHC1 PPP2CB;PPP2CA CBX4 MTA2 CBX2 PPP2R5E REST PHC3 SGK1-1 PPP2R5B PPP2R5A PPP2R5D PIP4K2A BMI1 PPP2R5C PIP4K2B RING1 RNF2 PIP5K1A PIP5K1B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 NTRK2 BDNF CHUK BAD GAB1 CASP9 PSMC2-1 PSMA5 NTF4 PSMA6 PSMA3 NTF3 PLCG1 PSMA4 PSMA1 EGF UBA52 EREG AREG PSMD12 BTC PSMD11 EPGN PSMD14 PRKCG HBEGF PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC NBEA ADRM1 PSMA2-1 MECOM SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NRG1 CAMKK1 CAMKK2 ESR1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 PPARG FGF7 FGF9 AKT2 FGF20 FGF23 AKT3 FGF22 AKT1 GAB2 USP7 FGF16 CSNK2A2 FGF19 FGF18 CSNK2B TRIB3 FGFR4 FGF10 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 MYD88 MOV10 AGO4 AGO2 CD28 EZH2 TRAF6 IRAK4 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism GAA PHKB GYG2 GYG1 EPM2A RPS27A UBB;UBC PYGB GBE1 AGL-1 CALM3;CALM1 PYGM PYGL PHKA1 GYS2 UGP2 GYS1 PHKG1 PHKA2 PHKG2 PPP1R3C NHLRC1 UBA52 PGM1 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants PDGFRA REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PRDM1 MLST8 PDPK1 PPP2R1B PPP2R1A CDKN2A ATM AKT2 RICTOR AKT3 RNF34 AKT1 USP7 USP2 UBA52 MDM2-2 RFFL MAPKAP1 MTOR PHF20 CHEK2 CDK1 PPP2CB;PPP2CA RPS27A UBB;UBC TP53 SGK1-1 MDM4 DAXX PPP2R5C CCNA2-1 PRR5 CCNA1 CCNG1 CDK2 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF4 FGF7 EGF FGF2 FGF10 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis SLC37A1 PGAM2 ENO1 G6PC2 ENO2 G6PC3 PC ENO3 PCK2 ALDOC ENO4 PGK1 ALDOB FBP1 ALDOA GAPDHS FBP2 G6PC1 GPI GAPDH-1 TPI1 SLC37A4 PCK1 PGAM1 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades DUSP6 RAC1 DUSP7 JAK1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ABHD17B ABHD17A RCE1 AGO3;AGO1 PAK1 PAK3 PAK2 KIT FLT3LG CDC42EP5 MARK3 GOLGA7-1 CDC42EP3 CDC42EP2 ZDHHC9 CDK1 ICMT ACTN2 SRC GRIN1 GRIN2D DLG2 NEFL MET SHC2 SHC3 YWHAB NRAS RAP1A MAP2K2;MAP2K1 PIK3CB MAPK1 RALGDS PDGFB HRAS MAPK3 PRKG2 BRAF FRS2 PIK3CA MAPK12 WDR83 RGL3 SOS1 CDC42 RGL1 RGL2 SHC1-1 PEA15 IL17RD MRAS RAPGEF2 FYN SHOC2 CSK SEPTIN7 CDC14B RASGEF1A ETV4 TNRC6A-1 IGF2BP1 PTPN11 MAPK6 MAPK4 TNRC6C ANGPT1 TEK TNRC6B XPO1 ERBB2 NRG2 NRG3 NRG4 ITGB3 ARAF PEBP1 ARRB1 PHB IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG EGFR KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 RASGRP1 RASGRP3 MAP3K11 VCL LAMTOR2 CALM3;CALM1 LAMTOR3 JUN FOXO3 RBX1 ARL2 HGF DLG1 DLG3 DLG4 DUSP10 DUSP5 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PTPN3 PDE6D PTPRA PDGFRA IL2RA KALRN SPRED3 ARTN SPRED2 RASA4;RASA4B GFRA3 SPRED1 SYNGAP1 GFRA2 RASA3 GFRA4 RASA1 RASA2 CUL3 PDGFRB RASAL1 RASAL2 RASAL3 DAB2IP NRTN NF1 KBTBD7 TGFA PPP5C PSPN PPP1CB PRKACA-1 DUSP16 PRKACB-1 CCND3 FOXO1-1 CAMK2B CAMK2D CAMK2A FNTA JAK3 PTK2 FLT3 TYK2 CAMK2G NCOA3 PPP1CC PPP2R1B PPP2R1A FNTB;CHURC1-FNTB IL2 SPTAN1 IL3 MAPKAPK5 SPTB PPP2CB;PPP2CA PPP2R5E IL2RG KRAS SPTBN4 SPTBN5 SPTA1 IL6 PPP2R5B PPP2R5A PPP2R5D NCAM1 PPP2R5C SPTBN1 SPTBN2 IL5RA CSF2RB CSF2RA RANBP9 IL5 IL3RA IL2RB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 HSPB1 PSMD1 GRIN2B PSMC2-1 FRS3 PSMA5 PSMA6 RET PSMA3 PSMA4 PSMA1 EGF UBA52 EREG AREG PSMD12 BTC PSMD11 BCL2L1 PTPN7 EPGN PSMD14 HBEGF PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 DNAJB1 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 RASGRF2 RASGRF1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NRG1 RAG2 KLB IRS1 RAG1 CSF2 ITGA2B IRS2 FGF1 FGF2 FGF3 FN1 FGF4 FGF6 FGF7 FGF9 FGF20 MYC FGF23 FGF22 FGF16 FGF19 FGF18 GFRA1 FGFR4 FGF10 GDNF PIK3R2 PIK3R1 CDC14A IL6R MOV10 AGO4 AGO2 PRKCQ DUSP4 RASGRP4 LYPLA1-1 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway FGB FGA VWF FGG F7 GPC1 APP F9 GPC3 GPC2 SERPINC1 GPC5 F3 GPC4 GPC6 GP9 GP1BB GP5 AGRN ANO6 F10 ANO5 F12 KLKB1 SERPIND1 F2 GP1BA SERPING1 F5 ITGA2B F8 PROC F2R HSPG2 PROS1 PF4;PF4V1-1 KNG1 SDC4 SDC2 SDC3 F13A1 SERPINE2 SERPINA5 THBD SMPD1 CD177 PROCR F11 F13B SDC1 SERPINE1 ADAMTS13 ITGB3 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs PRKAA2 CAMKK2 CALM3;CALM1 PRKAG1 PRKAB2 PRKAG2 PRKAB1 PRKAA1 PRKAG3 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 PTPN11 CTLA4 CD86 CD80 PPP2R1B LYN PPP2R1A PPP2CB;PPP2CA YES1 PPP2R5E LCK PPP2R5B PPP2R5A AKT2 PPP2R5D PPP2R5C AKT3 AKT1 FYN SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI PITPNM2 CDIPT CDS1 PITPNM1 PITPNM3 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures RBBP8 BARD1 XRCC2 XRCC3 PALB2 SLX1A;SLX1B RAD50 RAD51 ATM MUS81 MRE11 BRCA1 BRCA2 KAT5 EME2 EXO1 NBN GEN1 RMI2 RMI1 TOP3A SPIDR RAD51B RAD51D RAD51C DNA2 SEM1 RTEL1 BLM C1orf112 EME1-1 RAD51AP1 WRN BRIP1 SLX4 FIGNL1 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus LIG4 XRCC4 PSIP1 PPIA BANF1 XRCC6 XRCC5 KPNA1 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS SFTPB FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation TGFBR3 FGF4 FGF6 GIPC1 ANOS1-1 FGF9 FGF20 FGF23 FGF1 FGF2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNB1 GNB4 GNB3 GNB5 KCNJ11 KCNJ8 ABCC8 KCNJ2 KCNJ3 KCNJ12;KCNJ18 KCNJ4 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 KCNJ9 KCNJ15 KCNJ16 GNG10 KCNJ1 GNG2 GNG5 KCNJ14 GNG4 GNG8 ABCC9 GNGT1 GNG13 GNB2 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression EPAS1 PELP1 PTK6 NR3C1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF3F EIF3D EIF3A EIF3B RPS15 RPS14 RPS17 EIF5 RPS16 RPS19 EIF4E RPS18 EIF4B RPS11 EIF4G1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS27A RPS25 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 RPS2 FAU EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPS27 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 MAPK1 HRAS MAPK3 BRAF FRS2 PPP2R1A PIK3CA FGF1 FGF2 FGF4 GAB1 FGF9 SOS1 FGF20 FRS3 FGF23 PLCG1 FGF16 FGF18 UBA52 MKNK1 SPRY2 PTPN11 PIK3R1 PPP2CB;PPP2CA RPS27A UBB;UBC CBL NRAS GALNT3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA AMACR CRAT ACOX3 ACOXL CROT ACOT8 HSD17B4 ACOX2 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding OGG1 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism B3GALT6 CHSY1-1 OGN B4GALT1 CHST3 PAPSS2 OMD GPC1 HSPG2 HEXB GPC3 NCAN HEXA GPC2 BGN SDC4 GPC5 SDC2 GPC4 DCN SDC3 GPC6 ST3GAL3 BCAN VCAN AGRN FMOD CHST14 CSPG5 CSPG4 EXT1 B4GALT7 EXT2 KERA SDC1 SLC26A2 PRELP ACAN B3GAT3 LUM CHST6 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade DUSP6 DUSP7 JAK1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ABHD17B ABHD17A RCE1 KIT FLT3LG MARK3 GOLGA7-1 ZDHHC9 ICMT ACTN2 SRC GRIN1 GRIN2D DLG2 NEFL MET SHC2 SHC3 YWHAB NRAS RAP1A MAP2K2;MAP2K1 PIK3CB MAPK1 RALGDS PDGFB HRAS MAPK3 PRKG2 BRAF FRS2 PIK3CA MAPK12 WDR83 RGL3 SOS1 RGL1 RGL2 SHC1-1 PEA15 IL17RD MRAS RAPGEF2 FYN SHOC2 CSK RASGEF1A ANGPT1 TEK ERBB2 NRG2 NRG3 NRG4 ITGB3 ARAF PEBP1 ARRB1 PHB IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG EGFR KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 RASGRP1 RASGRP3 MAP3K11 VCL LAMTOR2 CALM3;CALM1 LAMTOR3 RBX1 ARL2 HGF DLG1 DLG3 DLG4 DUSP10 DUSP5 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PTPN3 PDE6D PTPRA PDGFRA IL2RA SPRED3 ARTN SPRED2 RASA4;RASA4B GFRA3 SPRED1 SYNGAP1 GFRA2 RASA3 GFRA4 RASA1 RASA2 CUL3 PDGFRB RASAL1 RASAL2 RASAL3 DAB2IP NRTN NF1 KBTBD7 TGFA PPP5C PSPN PPP1CB DUSP16 CAMK2B CAMK2D CAMK2A FNTA JAK3 PTK2 FLT3 CAMK2G PPP1CC PPP2R1B PPP2R1A FNTB;CHURC1-FNTB IL2 SPTAN1 IL3 SPTB PPP2CB;PPP2CA PPP2R5E IL2RG KRAS SPTBN4 SPTBN5 SPTA1 PPP2R5B PPP2R5A PPP2R5D NCAM1 PPP2R5C SPTBN1 SPTBN2 IL5RA CSF2RB CSF2RA RANBP9 IL5 IL3RA IL2RB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 GRIN2B PSMC2-1 FRS3 PSMA5 PSMA6 RET PSMA3 PSMA4 PSMA1 EGF UBA52 EREG AREG PSMD12 BTC PSMD11 BCL2L1 PTPN7 EPGN PSMD14 HBEGF PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 RASGRF2 RASGRF1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NRG1 KLB IRS1 CSF2 ITGA2B IRS2 FGF1 FGF2 FGF3 FN1 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF19 FGF18 GFRA1 FGFR4 FGF10 GDNF PIK3R2 PIK3R1 PRKCQ DUSP4 RASGRP4 LYPLA1-1 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN HSD17B10 MRM2 MRM3 MTERF3 MTERF4 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death CLSPN YWHAH TICAM2 TICAM1 PRKCD YWHAZ CD14 PAK2 STAT3 TP73 KPNB1 MLKL CDH1 CTNNB1 TP53BP2 E2F1 TFDP1 FNTA TFDP2 YWHAB PTK2 MAPK1 MAPK3 HSP90AA1 YWHAG IRF1 ROCK1 PMAIP1 SFN SPTAN1 DCC CDC37 CASP6 YWHAQ LY96 VIM BBC3 ARHGAP10 PPP3CC BMF H1-0 H1-3 H1-2 H1-5 H1-4 OMA1 STK24 GSN STK26 OPA1 DNM1L ACIN1 MAPK8 TLR4 PSMD8 PSMD6 PSMD7 PSMD2 BID PSMD3 PSMD1 CDKN2A PPP3R1 BMX SATB1 BAD CASP9 YWHAE PSMC2-1 AVEN PSMA5 DIABLO-1 PSMA6 UACA FASLG PSMA3 PSMA4 PSMA1 UBA52 BCL2 PSMD12 LMNB1 PSMD11 BCL2L1 PSMD14 APC PSMD13 NMT1 BCL2L11 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 APIP PSMB3 PSMB1 RPS27A UBB;UBC DAPK1-1 ADRM1 UNC5A CASP7 DSP UNC5B DBNL PSMA2-1 TJP1 TP53 MAGED1 SEM1 CASP3 GAS2 DAPK2 MAPT OCLN-1 DAPK3 DSG1 ADD1 PSMC5 PKP1 APPL1 PLEC PSMC6 DSG2 PSMC3 DSG3 PSMC4 PSMC1 TJP2 TRADD CASP8 CASP1 FLOT1 TNFSF10 FLOT2 AKT2 TP63 GZMH;GZMB-1 AKT3 PDCD6IP AKT1 RIPK3 PPP1R13B IL18 TRAF2 DFFB IL1A DFFA IL1B HMGB2 IRF2 CHMP4C KPNA1 PELI1 CHMP4B CHMP3 CHMP4A BCAP31 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CHMP6 CHMP7 APAF1 BIRC2 BIRC3 PRKN XIAP CYCS-1 SDCBP HMGB1-1 RIPK1 OGT-1 BAK1 FADD ELANE GSDMD CASP5;CASP4 ITCH CHMP2B C1QBP CHMP2A FAS BAX PRKCQ STUB1 GSDME PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling IKBKB CENPX IKBKG CHUK DUS2 STAT1 STAT3 PTPN2 CDK1 SPHK1 PRKRA TARBP2 ILF3 EIF2AK2 FAAP100 ISG15 TP53 HSPA8 DHX9 FAAP24 LOC105377022;FANCB UBE2I HSPA1L ILF2 DNAJC3-1 PPP2R1B PPP2R1A FANCM FANCL FANCA HSPA2 FANCE SUMO1 FANCG NPM1-2 FANCF ADAR CENPS-CORT;CORT;CENPS MAVS TRIM25 NCK1 EIF2S2 ARIH1 SNCA EIF2S3;EIF2S3B EIF2S1 MAP2K6 PPP2CB;PPP2CA UBE2L6 PPP2R5A HERC5 FANCC HSPA1A;HSPA1B TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling PTPN11 PIK3CB ANGPT1 HRAS PIK3R2 TEK PIK3R1 GRB7 PIK3CA SOS1 DOK2 SHC1-1 ANGPT4 ANGPT2 GRB14-1 NRAS BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina CASP6 LMNB1 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate CHIT1 SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B LCT MGAM TREH C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) TAB2 TAB1 PAK1 PRKCD PAK3 PAK2 UBE2D1 PYCARD AHCYL1 FCER1G PRKACA-1 PRKACB-1 NFKB2 PLCG2 ITPR1 MAP3K14 ITPR2 NRAS ITPR3 HRAS SYK PDPK1 FYN MUC12 MUC13 MUC15 MUC3A MUC5AC UBA3 EP300 MUC1 MUC2 MUC7 CREBBP MUC4 MUC6 CLEC4A CLEC4D MUC17 CLEC4E CLEC7A MUC5B CLEC6A MUC20 MUC21 CARD9 PSMD8 IKBKB PSMD6 PPP3CA PSMD7 PPP3CB PSMD2 RAF1 PSMD3 PSMD1 PPP3R1 IKBKG BTRC NFATC3 MAP3K7 NFATC2 SKP1 NFATC1 CHUK CALM3;CALM1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CASP8 ICAM2 ICAM3 RELB CLEC4M;CD209-2 RPS6KA5 IL1B LYN CDC34 TRAF6 UBE2V1 UBE2D3;UBE2D2 UBE2N TAB3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPL34 EIF3F RPL10A EIF3D RPL8 EIF3A RPL9 EIF3B RPL6 RPL7 RPS15 RPS14 RPS17 EIF5 RPS16 EIF5B RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 EIF4E EIF4B EIF4G1 UBA52 RPS27A EIF2S2 EIF2S3;EIF2S3B EIF2S1 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M RPL4 EIF3K RPL30 EIF3L RPL3 EIF3I EIF3J RPL32 EIF3G EIF3H RPL31 EIF3E PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi RAB6A NOTCH2 ST3GAL6 NOTCH3 ATP2A3 MFNG ATP2A2 TMED2-1 NOTCH4 ATP2A1 RFNG NOTCH1 SEL1L B4GALT1 LFNG FURIN ST3GAL4 ST3GAL3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MECR ECHS1 HADH ACADM HADHA HADHB-1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors PROC F7 GAS6 F9 F10 PROS1 F2 GGCX DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants CDC37 HSP90AA1 ERBIN ERBB2 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome TXN RELA PYCARD PSTPIP1 TXNIP HSP90AB1 NFKB1 CASP1 MEFV HMOX1 NFKB2 APP PANX1 NLRP3 P2RX7 SUGT1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A RAC1 FARP2 TLN1 RND1 PLXNA1 PLXNA4 NRP1 PIP5K1C PLXNA2 FES FYN PLXNA3 RRAS DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) SLC6A19 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT2 CNOT3 CNOT8 BTG4 CNOT9 ZFP36L2 TNKS1BP1 EIF4E DICER1 EIF4B PAIP1 PABPC1;PABPC3 EIF4A2 AGO2 EIF4A1 EIF4G1 CNOT6L CNOT10 CNOT4 CNOT6 EIF4A3 CNOT7 CNOT11 CNOT1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB CAMKK2 CAMK4 CALM3;CALM1 KPNA2 CAMK2G CAMK2B CAMK2D CAMK2A CAMKK1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 COL4A5 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 SLIT2 RPL35 RPL38 ROBO1 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A MSI1 RPLP2 DAG1 RPL36-1 HOXA2 ISL1 RPS3A CUL2 GSPT2 GSPT1 RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 LHX3 RPL12-1 LHX2 RPS2 LHX4 RPL18 LHX9 RPL17 ROBO2 RPL19 RPL35A USP33 RPL23A RPL22L1 UPF2 FAU RPL26L1 ETF1 LDB1 ZSWIM8 SLIT1 RPS27 ELOC-1 ELOB NCBP1 EIF4A3 CASC3 NCBP2-1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RBM8A EIF4G1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 MAGOH;MAGOHB PSMD12 PSMD11 PSMD14 PSMD13 UPF3B RNPS1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RPL4 RPL30 RPL3 RPL32 RPL31 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling IL1RL1 IL33 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins TACR2 TACR3 TACR1 TAC3 TAC1 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism GPT RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription CBFB RUNX1 AXIN1 ESR1 KCTD6 GPAM INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation GNB1 PAX6 GNB3 GPR119 ISL1 DPP4 GNAT3 CDX2 GIP LEP SPCS3 GATA4 SPCS2 SPCS1 FFAR4 CTNNB1 PCSK1 FFAR1 SEC11A SEC11C GCG GNG13 TCF7L2 GRP PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 EEF1A1 RPS6 RPSA RPL24 EEF2 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 RPL4 RPL30 RPL3 RPL32 RPL31 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription ZCRB1 VHL RB1 DDX5 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate UGDH SLC35D1 UXS1 UGP2 SLC35D2 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands BDNF DLL1 SIN3A CRH HDAC1 SST CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants NCOR1 PSENEN TBL1XR1 PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SKP1 HDAC5 HDAC2 UBA52 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 MIB2 CUL1 SNW1 JAG2 JAG1 ADAM10 HDAC10 DLL1 HDAC11 MIB1 DLL4 NEURL1B ADAM17 NCOR2 RPS27A NEURL1 KAT2B UBB;UBC KAT2A NOTCH1 RBX1 RBPJ HDAC4 MAMLD1 CCNC-1 MYC HDAC3 HEY1 MAML2 HEY2 HES1 MAML1 EP300 CDK8 CREBBP SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants BRAF PPP1CC MRAS ARAF SHOC2 RAF1 YWHAB PPP1CB THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) GNB1 MAPK1 GNB4 GNB3 GNB5 MAPK3 F2RL2 F2RL3 GNAQ GNA13 GNA12 F2R GNG10 GNG2 GNG5 GNG4 GNG8 GNA14 ARRB1 GNA15 F2 GNGT1 GNA11 GNG13 GNB2 ARRB2 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection TAB2 TAB1 JAK1 NOD1 YWHAH NOD2 IRAK2 ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 YWHAZ TRAF3 MAN2A1 IKBKE MGAT5 ST3GAL4 MGAT1 MGAT2 STAT1 ST3GAL1 ST3GAL2 TLR8 ST3GAL3 TLR7 ST6GAL1 EDEM2 VCP-1 MOGS TUSC3 GOLGA7-1 MGAT4C ZDHHC9 MGAT4B ANO8 MAN1B1 ANO9 ST6GALNAC3 ANO6 ST6GALNAC4 ANO4 ANO5 TMEM258 ANO2 CAV1 ANO3 MBL2-1 ANO1 MASP1 OST4 IRF7 OSTC STT3A ANO10 STT3B GSK3A PARP6 PRMT1 YWHAB PARP4 GSK3B GALNT1 PARP16 PARP9 STING1 PARP14 PARP8 PARP10 YWHAG PDPK1 DDOST DAD1 HSP90AB1 SFN PTPN11 CTSV;CTSL PTPN6 FURIN CREBBP BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG ISCU GJA1 YWHAE VHL TUFM SEC23A SAR1B SEC24B SEC24A SEC24D-1 VPS33A PATJ VPS33B SEC24C MPP5 ZCRB1 CRB3 G3BP1 G3BP2 CSNK1A1 TBK1 IRF3 DDX58 NUP205 IFIH1 RNF135 NUP188 SIKE1 AAAS MAVS TRIM25 NUP42 SRPK2 NUP62 SRPK1 TPR NUP88 RAE1 CHMP4C NDC1 CHMP4B NUP214 SFTPD CHMP3 NUP210 CHMP4A NUP155 NLRP12 NUP153 CHMP6 NUP93 CHMP7 IL17F NUP50 POM121;POM121C IL17A NUP35 NUP54 CHMP2B CHMP2A CNBP-1 VPS39 VPS18 ATG14 VPS11 VPS16 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 KPNA2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RB1 ISG15 LARP1-1 RPS25 RPS29 RPS20 RPS21 RPS24 VPS41 RPS23 NLRP3 VPS45 DDX5 RPS4X NUP107 TYK2 TOMM70 IFNAR1 HSP90AA1 IL17RC IL17RA RPS3A TLR1 CANX TLR2 RPS27L RPS15A STAT2 RPS3 IRAK1 RPS2 NRP1 HSPG2 FAU NUP160 SDC4 SDC2 SDC3 NUP85 YWHAQ RPS27 SDC1 SEC13 NUP133 NUP43 IKBKB IFNB1-4 IKBKG RANBP2 MAP3K7 CHUK GPC1 GPC3 TMPRSS2 ACE2 UBA52 GPC2 GPC5 GPC4 GPC6 NUP37 AGRN RPS27A UBB;UBC GEMIN2 SNRPD2 SNRPD1 TJP1 SNRPD3 SMN2;SMN1 GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 TKFC SNRPB DDX20 SNRPE-2 SNRPG-2 UBE2I PIK3R4 SUMO1 AKT2 AKT3 AKT1 B2M PIK3C3 RPN2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RPN1 RIPK2 TRAF6 UBE2V1 MAGT1 UBE2N TAB3 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription SP1 SNAI1 ZEB2 PRDM8 BHLHE22 HEYL HOXC8 FOXF1 ILF3 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling HSP90AA1 EGFR MATK PTPN12 USP8 RNF41 ERBIN CUL5 AKT2 PTPN18 AKT3 AKT1 EGF UBA52 EREG BTC HBEGF CDC37 RPS27A UBB;UBC ERBB2 NRG2 NRG3 NRG4 STUB1 NRG1 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases GAA G6PC3 GYG2 GYG1 EPM2A RPS27A UBB;UBC GBE1 G6PC1 GYS2 GYS1 PPP1R3C NHLRC1 UBA52 SLC37A4 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling PM20D1 UCP1 SLC25A27 UCP3 UCP2 SLC25A4 SLC25A14 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling GNB1 GNB4 RAC1 GNB3 GNB5 AP2A1 AGO3;AGO1 AP2A2 AP2M1 AP2S1 TCF7 CTNNB1 DVL1 DVL2 DVL3 CAMK2A AP2B1 ITPR1 ITPR2 CLTC ITPR3 CLTA GNAT2 PRKG2 PRKG1 PRKCA PFN1 PLCB3 PLCB1 PLCB2 NLK PDE6B PDE6A GNAO1 LEF1 SMURF2 SMURF1 TCF7L2 TCF7L1 TNRC6A-1 TNRC6C TNRC6B ARRB2 PSMD8 PSMD6 PPP3CA PSMD7 PPP3CB PSMD2 PSMD3 WNT5B PSMD1 ROR1 ROR2 PPP3R1 MAP3K7 NFATC1 CALM3;CALM1 PRKCB PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 VANGL2 PSMA1 UBA52 SCRIB PSMD12 PSMD11 PSMD14 PRKCG PSMD13 PSMA7 PSMB6 DAAM1 PSMB7 PSMB4 CLTB PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GNGT1 WNT5A RYK-1 RHOA PARD6A RAC3 GNG10 WNT11 PRICKLE1 GNG2 GNG5 GNG4 GNG8 WNT1 WNT4 FZD1 FZD3 FZD2 FZD5 FZD4 MOV10 AGO4 AGO2 FZD7 FZD6 FZD8 GNG13 GNB2 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome PSMD8 PSMD6 PSMD7 CSNK1A1 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 GLI3 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PRKACA-1 PSMB1 PRKACB-1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GSK3B DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling PTPN11 HRAS FRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 SOS1 FRS3 FGF20 FGF23 FGF22 FGF16 FGF18 NRAS FGF10 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TPGS1 TTL TPGS2 SVBP TTLL12-1 ARPC4-TTLL3;TTLL3 AGTPBP1 TUBA1C NICN1 TUBA1A LRRC49 VASH2 TUBB1 VASH1 AGBL5 TTLL7 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 AGBL3 TTLL1 AGBL2 TTLL11 TUBB2B;TUBB2A TTLL9 TUBB3;TUBB6 TUBA3E;TUBA3C-1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane MTMR4 MTM1 INPP5F PIK3C2A MTMR10 MTMR12 PIK3R4 FIG4 PIKFYVE PI4K2B INPP4A MTMR2 INPP4B PI4K2A VAC14 PIK3C3 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) DAG1 LAMA5 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 DRP2 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 AGRN SGCE SGCD SGCA SGCB DMD SGCG SNTA1 DTNA DTNB SGCZ SSPN SNTB1 SNTB2 UTRN TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic POLD2 RPA1 RPA2 POLE4 RPA3 LBR POLE2 POLE3 ANAPC15 FBXL7 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 HDAC1 CCNB1 CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SET-1 TPX2 MAPK1 HSP90AB1 GORASP1 RAB1A RAB1B USO1 RBL2 GINS1 RBL1 GINS2 CDC45 MCM7 GINS3 XPO1 GINS4 MCM3 MCM4 MCM5 EP300 MCM6 MCM2 JAK2 GTSE1 FKBPL HJURP MIS18BP1 YWHAE CDC25C CDC25A FBXL18 LMNB1 CDC25B GOLGA2 PHLDA1 RBX1 ARPP19 NCAPH2 NCAPG2 NIPBL ENSA NCAPD3 RAB2A CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL GORASP2 MCPH1 CDC6 CHMP4C CHMP4B CHMP3 CHMP4A ESCO1 ESCO2 CHMP6 PTK6 CHMP7 LIN54 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 CHMP2B CHMP2A PRIM2 PRIM1 POLA1 POLA2 RB1 CDKN1C PRKACA-1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 PRKAR2B E2F3 SKP2 TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC FOXM1 PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 LIG1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 CCNA2-1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C CCNA1 KIF2B ITGB3BP PAFAH1B1 NEK9 DYNC1I2 CENPA NEK6 NEK7 AURKB NSL1 TOP2A CENPC NUP43 BUB3 CDKN2D BUB1 CDKN2B DYNC1I1 CLASP1 CDKN2C CLASP2 CENPT CDKN2A RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 HMMR CCNH CDK7 MNAT1 H2AC14 AKT2 MYC AKT3 AKT1 CSNK2A2 CSNK2B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN H2AC20 H2AB2;H2AB3;H2AB1 PPP1R12A H2AJ CSNK2A1;CSNK2A3 OPTN-1 AKAP9-1 H2BC5 H2BC1 NEK2 H2AC4 CCP110 CEP250 CDK5RAP2 CEP135 CSNK1D GSK3B H2BC21 YWHAG PRKCA CEP70 CEP72 H2AZ2;H2AZ1 CEP192 CEP76 CEP78 EML4 PLK4 ODF2 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CEP57 CETN2 CEP164 H2BC15;H2BC3;H2BC11;H2BC12 SPAST VPS4A CC2D1B SIRT2 IST1 VRK1 ACTR1A LEMD2 ESPL1 CNTRL TNPO1 CEP290 RAB8A HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 PTTG1;PTTG2 TUBA1C TUBA1A DCTN2 CENPJ SSNA1 TUBB1 DCTN3 HAUS8 HAUS7 RCC1 PCNT OFD1-1 CEP152 TUBB2B;TUBB2A NEDD1 KMT5A ALMS1 TUBA4A CEP41 CEP43 DYRK1A TP53 TK1 DHFR2;DHFR TUBB3;TUBB6 TYMS SMC4 TUBAL3 PPP2R3B SMC2 TUBGCP2 MZT2A;MZT2B NCAPG NCAPH MAX TUBGCP5 TUBGCP6 TUBGCP3 TUBA3E;TUBA3C-1 TUBGCP4 NUMA1 TUBG2 NME7 MZT1 NCAPD2 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E TUBA8 NUP205 NUP188 AAAS NUP42 NUP62 TPR BANF1 NUP88 RAE1 NDC1 ANKLE2 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 ORC5 EMD ORC4 ORC6 ORC1 MCM8 ORC3 KIF20A ORC2 LEMD3 E2F5 E2F6 KIF23 PKMYT1 PPP1CB KPNB1 FBXO5 LPIN1 LPIN2 LPIN3 PPP2R2A;PPP2R2D HSP90AA1 RAN AJUBA MYBL2 AURKA CDK11A;CDK11B PPME1 BORA OBI1 LCMT1 TICRR E2F4-1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC CDC7 SKP1 PRKCB FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 RRM2-1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UBE2I SUMO1 POLE RFC5 GMNN CDC14A RFC3 RFC4 RFC1 CDT1 RFC2 FEN1 MCM10 ABL1 DBF4 DNA2 C1orf112 PCNA POLD3 POLD4 POLD1 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope SPRR3 CSTA KLK5 EVPL KLK8 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 TGM1 CASP14 LIPJ SPRR1A;SPRR1B LIPN LIPM PRSS8 LIPK TGM5 ST14 CDSN SPINK6 SPINK5 KLK14 KAZN CELA2B;CELA2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 PKP4 DSC1 IVL DSC2 DSC3 CAPNS1 CAPN1 DSP JUP DSG1 FURIN PKP1 PCSK6 DSG2 PERP DSG3 KLK13 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function WT1 MPHOSPH8 H2AJ CSNK2A1;CSNK2A3 FOXQ1 PRKCSH AGO3;AGO1 TLE1 ZBTB33 ARHGAP32 HDAC2 GANAB PKM SUZ12 H2BC5 HDAC1 H2BC1 CTSS MOGS SMARCA4 MCRIP1 CTSB KLF4 H2AC4 CTNNA1 MYCN RB1 TMEM258 SNAI2 SRC CTNND1 CDH1 TWIST2 SNAI1 CTNNB1 BANP OST4 EPS15 CBLL1 SEC11A OSTC SEC11C STT3A KDM1A MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 CANX DDOST POMT2 DAD1 SPCS3 SPCS2 ZNF217 SPCS1 POMT1 TFAP2A RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TNRC6A-1 MDM2-2 ANK3 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 TGIF2 ARID1A TNRC6B FURIN PCSK6 ZEB1 SIRT1 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VCL PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ZEB2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 KMT5A PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 JUP PSMC5 DNM2 PSMC6 PSMC3 PSMC4 PSMC1 SP1 CTBP2 CTBP1 H2AC14 MYC CSNK2A2 CSNK2B RPN2 RPN1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FOXA2 MTBP MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 PCSK7 ZMYM2 RACK1 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation NCOR1 CNOT9 H2AJ PAXIP1 JUN SUZ12 RARG H2BC5 H2BC1 YY1 H2AC4 KMT2C RARB PBX1 KMT2D POLR2A POLR2B POLR2C DPY30 POLR2D POLR2E POLR2F PCGF2 POLR2G H2BC21 POLR2H WDR5 NCOA3 POLR2I EGR2 HOXA2 POLR2L EED H2AZ2;H2AZ1 RXRA POLR2J;POLR2J2;POLR2J3 KDM6A RARA H2AC14 CTCF RBBP4 PAGR1 RBBP5 HOXA3 HOXA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PKNOX1 HOXA4 PIAS2 RBBP7 HOXB3 HOXB2 HOXB1 AJUBA HOXD1 PAX6 HOXC4 MEIS1 HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MAFB HOXD4 HOXB4 HOXD3 ZNF335 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EP300 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L CNOT6 CREBBP NCOA6 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization TIMM23 TIMM22 TIMM21 ATP5MC1 NDUFB8 TOMM40 TIMM13 ATP5F1A TIMM10 ATP5F1B CHCHD3 CHCHD10-1 SAMM50 STX5 UBL4A PEX16 TIMM8B ATAD1 TIMM8A IDH3G HSPA9 SGTA GFER GDAP1 VAPA MTX1 TOMM7 CHCHD7-1 MTX2 UBE2D1 PRNP ABCD2 ABCD3 PEX3 HSCB BCS1L IDH1 CYC1 FXN TOMM70 ACBD5-1 SEC61G SEC61B OTC OTOF CAT GNPAT HSPD1 HMOX1 SLC25A12 SLC25A13 COQ2 USP9X PECR ZFAND6 IDE CROT PEX26 APP SCP2 NUDT19 MPV17 GSTK1 ECH1 LONP2 PIPOX UBA52 PEX1 STX1A BAAT PEX7 VAMP2 ACOX2 ACOX1 PEX6 UBE2D3-1 AGPS ACOX3 AGXT PAOX PHYH-4 DDO HAO1 HACL1 ACOT2;ACOT1 NOS2 EPHX2 PMPCB TYSND1 RPS27A VDAC1 UBB;UBC DHRS4 NUDT7 PMPCA AMACR DAO CRAT GRPEL1 PEX10 PEX2 PEX12 PEX13 PEX14 ACOT8 HMGCL EHHADH-1 ACAA1-1 HSD17B4 DECR2 ABCD1 SLC27A2 ACOT4 TOMM20 TOMM22 PEX19 CHCHD4 CHCHD5 TIMM17A-1 CHCHD2 CMC2 SLC25A17 COX19 PEX11B COX17 SLC25A4 TIMM50 SLC25A6 BAG6 PITRM1 EMD LDHD GRPEL2 COA4 DNAJC19 FIS1 TIMM44 TIMM10B CS PXMP2 PXMP4 ACO2 TAZ TIMM17B GET1 GET3 UBE2D3;UBE2D2 GET4 CAMLG ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane HAUS4 KIF24 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 TMEM216 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 B9D2 HAUS8 HAUS7 TMEM67 PCNT OFD1-1 SEPTIN2 CEP152 CDK1 SCLT1 RAB11A NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP162 CEP250 B9D1 CEP41 CEP97 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B RPGRIP1L FBF1 TTBK2 HSP90AA1 YWHAG NPHP1 CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E MARK4 CEP76 CEP78 PLK4 ODF2 RAB3IP AHI1 MKS1 CEP83 CEP89 CEP57 C2CD3 CETN2 CEP164 ACTR1A TCTN3 TCTN2 MAPRE1-1 CNTRL TCTN1 CC2D2A CEP290 RAB8A IQCB1 CKAP5 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 CYP2U1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity TGIF1-1 MAPK1 PPM1A NCOR1 MAPK3 NEDD4L PARP1 TRIM33 ATP1B4 USP9X SMAD2;SMAD3 SMAD4 SMURF2 SKI SMAD7 UBA52 UBE2D1 HDAC1 UBE2D3-1 SNW1 TGIF2 WWTR1 RPS27A NCOR2 UBB;UBC SKIL RNF111 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition FBXO5 PLK1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes DDX11 EDEM1-1 WIPI1 PDIA6 PDIA5 ACADVL DNAJC3-1 CTDSP2 KDELR3 DCTN1 TLN1 CXXC1 EXTL1 CUL7 SSR1 DNAJB9 KLHDC3 ZBTB17 PREB WFS1 EXTL2 GFPT1 YIF1A SHC1-1 SRPRA HDGF TPP1 GOSR2 EXTL3 JMJD7-PLA2G4B;PLA2G4B SEC31A LMNA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARFGAP1 DNAJB11 SYVN1 ATP6V0D1 ADD1 PPP2R5B SRPRB-1 FKBP14 HYOU1 MYDGF GSK3A TATDN2 TSPYL2 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal MGMT LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation COLEC11 COLEC10 FCN2;FCN1 MBL2-1 MASP1 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus PROC F7 GAS6 F9 F10 PROS1 F2 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAP2K2;MAP2K1 PTPN11 JAK2 MAPK1 TYK2 IL6 JAK1 IL6R CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling NGFR SMPD2 NGF DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE MTRR MTR-1 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers SRI CALM3;CALM1 SLC24A5 SLC8B1 SLC24A2 SLC24A3 SLC8A1 SLC8A2 SLC8A3 SLC24A1 SLC24A4 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism BCKDHB MCCC2 DBT MCCC1 DLD PPM1K AUH IVD HIBCH ECHS1 HSD17B10 CRAT GLYAT ACAD8 HIBADH ACADSB ALDH6A1 BCAT1 SLC25A44 BCAT2 BCKDK BCKDHA ACAT1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 MAPK14 GNAQ P2RY1 PLA2G4A GNA14 GNA15 GNG13 GNGT1 GNG10 GNA11 GNB2 GNG2 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis B3GNT7 B3GNT4 B3GNT2 CHST1 OGN B3GNT3 CHST2 B4GALT2 B4GALT3 B4GALT1 CHST3 OMD ST3GAL4 ST3GAL1 SLC35D2 ST3GAL2 ST3GAL3 FMOD ST3GAL6 B4GALT6 B4GAT1 KERA B4GALT4 B4GALT5 PRELP ACAN LUM CHST6 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin ALDH2 MAOA SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy DYNC1I2 MAP1LC3B2;MAP1LC3B-1 TOMM40 ULK1 DYNC1I1 CSNK2A1;CSNK2A3 DYNC1H1 ATM TOMM7 OPTN-1 CETN1 PARK7 PLIN2 UBA52 CFTR HDAC6 MAP1LC3A FUNDC1 USP30 PCNT ATG9A VCP-1 UBE2D3-1 ATG12-1 SQSTM1 PEX5 ATG5 NBR1 VDAC2-1 VDAC3 RPS27A VDAC1 HSF1 UBB;UBC PLIN3 HSPA8 IFT88 TOMM70 HSP90AA1 TBK1 DYNC1LI1 PRKAA2 DYNC1LI2 PRKAB2 CSNK2A2 ARL13B PRKAB1 CSNK2B MTERF3 EPAS1 TOMM20 TOMM22 PRKN MFN1 MFN2 PRKAG1 PRKAG2 UBE2V1 UBE2D3;UBE2D2 PINK1 UBE2N PRKAG3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification BARD1 RPA1 OTULIN BRCC3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 PALB2 CLSPN TP53BP1 RCE1 BABAM1 BABAM2 SIN3A UIMC1 ABRAXAS1 RNF168-1 RAD52 HDAC2 DCAF13 UBE2C PRMT3 UBE2E1 H2AC16;H2AC11 UBE2D1 HDAC7 UBE2S HSP90B1 CDK1 PML STAM HGS STAM2 PRKDC INS;INS-IGF2 CD109 ZNF350;ZNF432 MCFD2 SERPINA1 PPP6C TFG PPP6R1 PPP6R3 CTSC RAB27B TMED2-1 TRAPPC2L CALU TRAPPC2;TRAPPC2B LMAN1L KCTD6 F5 TRAPPC6A F8 TBC1D20 NPM1-2 TRAPPC6B GORASP1 PREB SMAD1 SEC22B SMAD4 SEC22A QSOX1 CBX5 SEC22C AHSG SMURF2 RAB1A TMED10 STX17 LMAN2L SMAD7 RAB1B SPP2 GOSR2 USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC3 TRAPPC1 TRAPPC4 AXIN1 TRAPPC10 APLP2 TRAPPC5 TRAPPC9 SEC23IP CNIH1 SCG3 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 THBS1 CNIH3 BET1 NRIP1 EP300 APOB MMRN1 PPARGC1A NCOA1 NCOA2 ARRB1 CREBBP ARRB2 APOA1 UCHL1 SENP8 UCHL3 HCFC1 FOXK2 FOXK1 FGA MBD5 MBD6 ASXL1 FGG ASXL2 NFE2L2 TPGS1 TTL TPGS2 CALM3;CALM1 SVBP TTLL12-1 ARPC4-TTLL3;TTLL3 AGTPBP1 NICN1 APP LRRC49 VASH2 VASH1 AGBL5 TTLL7 CDC25A AGBL4 TTLL6 TTLL5 TTLL4 GOLGA2 AGBL1 AGBL3 TTLL1 AGBL2 TTLL11 TTLL9 GOLGB1 RBX1 ALG11 CAND1 RAB2A EDEM1-1 PDIA6 CP TF KDELR3 DCTN1 WFS1 DBT TOMM20 CD55 ADRB2 COL7A1 PCSK9 CUL3 KBTBD7 XRCC4 BAP1 APOA2 UBXN1 APOA5 VCAN USP30 GLB1 PGAP1 LYPD1 LYPD2 LYPD3 THY1 ARSB LYPD4 LYPD5 LYPD8 CDKN1A RHOT1 FUCA1 LYPD6B PIGS PIGU GPIHBP1 PIGT PIGO PIGN JOSD2 PIGP JOSD1 SKP2 DAXX PIGZ PIGW PIGV CHST8 CRPPA PIGC ALB PIGB PIGA P4HB OTUD7B PTRH2 PIGK TNFAIP3 PIGM NUP107 PIGL USP21 PIGG USP4 PIGF ARF5 SMC3 CYLD PIGH FAM86B1;EEF2KMT;FAM86B2 CDC20 ARCN1 ETFBKMT LY6K POFUT2 LY6D SUDS3 LY6H ATXN7 DYNC1LI1 SPRN ETFB SPACA4 DYNC1LI2 MDGA2 ALG10;ALG10B MDGA1 RECK KDELR2 NRN1 CDCA8 ART3 ART4 SNX3 NTNG1 NUP160 NTNG2 SDC2 BST1 GPAA1 OTUD7A MIA2 NUP85 RAB22A RAD21 KIN STAMBPL1 NDUFAB1 ST3GAL6 ENGASE OTUD5 B4GALNT2 RXYLT1 STAG1 PRND STAG2 EMID1 VCPIP1 CNTN5 B4GAT1 UBE2T ALPL CNTN3 FUT6;FUT5;FUT3 CNTN4 NGLY1 SEC13 MYSM1 VCPKMT NUP133 MMRN2 OTUB1 OTUB2 GOSR1 TEX101 RAB40C RANGAP1 TNIP1 SMC1A RNF128 GPLD1 INCENP LIPT2 BIRC5 LIPT1 CHST10 GP2 TADA2B ASGR1 DYNC1I2 ASGR2 PRSS21 AURKB TNIP3-2 B3GNT7 COPZ2 B3GNT4 GALNT11 COPZ1 GALNT14 NUP43 WDR20 B3GNT2 GALNT13 METTL21A GALNT16 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L GALNT15 DYNC1I1 PRSS41 GALNT18 B3GNTL1 EEF1AKMT2 EEF1AKMT1 GALNT10 GALNT9 RAB3B GALNT8 RAB3C RANBP2 DYNC1H1 RAB3D B3GNT9 B3GALNT2-2 B3GNT8 RAB44 B3GNT6 RAB42 B3GNT5 CHST4 LARGE2 GALNT9;GALNT17 TECTB GCNT1 RAB2B GCNT3 USP5 SLC17A5 GCNT4 USP3 GPC3 GALNT7 RAB30 GALNT6 RAB36 GALNT5 RAB37 GALNT4 RAB34 GALNT2 FKBP8 A4GNT STAMBP GALNTL5 RAB4B GALNTL6 GCSH-3 PLET1 NUP37 CPM PSCA RTN4RL2 BET1L METTL22 PTP4A2 RTN4RL1 RAB20 VDAC2-1 RAB25 RAB26 RAB23 VDAC3 RAB24 RAB29 FKTN VDAC1 SLC35A4 FKRP RAB15 RAB19 RAB17 FOLR2 NFU1 YOD1 FUT10 FUT11 UMOD LIAS OTOA MLEC ZRANB1 TMED3 TMED7 TMED9 CTR9 IZUMO1R WDR61 NRN1L RTF1 LY6G6C CDC73 LSAMP COPG2 TMEM129 HLTF COPG1 LEO1 COPB2 RNF152 COPA SHPRH NTM PEX10 COPB1 PEX2 MAN2A2 PEX12 PIGX-1 PEX13 TMEM115 PEX14 COPE RNF40 B4GALT2 USP37 RNF144A B4GALT3 USP47 SELENOS B4GALT1 USP48 FDX1 WAC-1 USP49 RNF181 USP42 PAF1 H2AC14 USP44 PLAUR MYC HK1 POMGNT2 USP26;USP29 USP16 PROS1 ABRAXAS2 OPCML USP24 USP25 USP20 NEGR1 RPN2 USP22 EPAS1 USP28 BMP4 XPNPEP2 RPN1 POMK TECTA;TBCEL-TECTA GAS6 LY6E HIF1A B4GALT6 MGAT3 B4GALT4 B4GALT5 ST6GALNAC6 RAB10 H2AC20 RAB14 RAB13 RAB27A MAGT1 MGAT5B-1 B3GNT3 DERL1 DERL2 OS9 TRAF3 IKBKE SUZ12 H2BC5 H2BC1 VCP-1 TUSC3 MTA1 ANO8 H2AC4 TMEM258 TOPORS SEL1L OST4 NFKB2 TNC COPS5 OSTC STT3A STT3B RNF185 GALNT1 FBN1 H2BC21 WDR5 FOXL2 HIC1 SP3 DDOST DPAGT1 ALG8 DAD1 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 RNF5 MPDU1 RFT1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TDG H2BC15;H2BC3;H2BC11;H2BC12 ELOC-1 ELOB CDH2 TAF10 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DCAF7 TUBA1C PARK7 TUBA1A TUBB1 FBXO4 CFTR FBXO6 VGF AXIN2 FBXW4 DCAF8 DCAF5 FBXW10;CDRT1 DCAF6 FBXW5 WSB2 TUBB2B;TUBB2A DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 FBXW7 OBSL1 DCUN1D5 FBXW9 DCUN1D3 FBXW2 DCUN1D4 DCUN1D1 COMMD8 COMMD9 PUM2 HIF3A DDA1 ANKRD9 TP53 COMMD2 COMMD3 COMMD1 TUBB3;TUBB6 COMMD6 COMMD7 COMMD4 SPSB3 CCDC8 CUL9 UBD NAE1 SOCS6 SOCS5 TUBA3E;TUBA3C-1 WDTC1 CCDC22 DCUN1D2-1 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 TUBB4B DCAF11 FEM1A FEM1B TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 NEURL2 ERCC8 FBXL3 RHOA FBXL5 PROC DDX58 NUP205 IFIH1 NUP188 RNF135 AAAS MAVS TRIM25 NUP42 NUP62 TPR NUP88 RAB5B RAE1 RAB5C NDC1 NUP214 RAB5A NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 ARFGAP3 CALR-1 DLAT RAB7A RPL8 LMAN1 STX5 YKT6 KTN1 SERPINC1 MFGE8 RPS6 CST3 TGFB1 EIF2AK2 RPL27A GMPPB PMM1 MPI RPS23 GMPPA PMM2 DAG1 PARP1 CUL2 DNAJC3-1 CANX GALNT12 SEMA5A POMT2 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 RPS2 ADAMTS4 ADAMTS5 C1GALT1C1 ADAMTS2 USP33 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL2 MUC12 ALG14 ETF1 MUC13 MUC15 THSD7A ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUC3A POMGNT1 MUC5AC ADAMTS20 B3GLCT ST6GALNAC1 CFP VNN1 CMAS THBS2 ADAMTS12 NANP VNN2 THSD1 FPGT PGM3 THSD4 ADAMTS10 GNPNAT1 ADAMTS16 NANS ADAMTS15 GFUS NUDT14 MUC1 ADAMTS14 ST6GAL2 ALG5 MUC2 ADAMTS13 SLC35C1 ADAMTS19 RENBP ADAMTS18 DHDDS ADAMTS17 DPM1 DPM2 MUC7 DPM3 MUC4 ST6GALNAC5 MUC6 GALNT3 GNE UAP1 MUC17 NPL C1GALT1 NEU2 MUC5B NEU3 MUC20 NEU4 MUC21 DHRSX GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 CTSA SLC35A1 NUS1 ST8SIA1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK U2AF2 DOLPP1 SQSTM1 CHRDL1 FSTL1 ARF1 CTSZ HSPA8 F2 MAT2B LAMB2 FN1 LAMB1 LAMC1 FGF23 KNG1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSMD9 CKAP4 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 POMP PSMB10 PSMA8 PSMF1 LRR1 PSMB8 CCNF PSMB9 KEAP1 PSMG3 PSMG4 PSMG1 PSMG2 CDC34 TRAF6 HERC2 FBXO7 UBE2D3;UBE2D2 UBE2N FBXO9 DLST TAB1 WSB1 CSF1 FBXO2 RNF123 AMER1 KDM8 STS UBE2J2 OGFOD1 ARSA IL33 JMJD4 DHPS FN3KRP JMJD7 SIAH2 SUMF2 SUMF1 JMJD6 TPST2 F7 FBXL8 MITF TPST1 FBXL4 F9 FBXL7 RCCD1 EIF5A2 DNAJC24 ARSL DPH1 DPH2 ARSJ LRRC41 ARSK HDAC1 ARSH ARSI GAN DPH5 DPH6 GPR75-ASB3;ASB3-1 DPH7 ARSG KLHL2 KLHL3 ZC3H15 UBE2G1 RWDD1 UBE2G2 FN3K KLHL9 ICMT SPSB2 F10 SPSB1 EIF5A;EIF5AL1 DOHH KLHL5 ARSD-1 RIOX1 GGCX RIOX2 KBTBD8 SPSB4 DRG1 DRG2 FBXO27 CGA UBE2Z FBXO21 FBXO22 FBXW12 ARFGAP2 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 UBE2V2 CUL7 CUL5 GPS1 UBA6 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 RNF20 UBE2F UBE2H KLHL25 ZBTB16 COPS4 KLHL21 COPS2 KLHL22 BTBD6 FBXO30 HNRNPC FBXO31 ARFGAP1 KLHL20 UBE2W UBA3 UBA1 UBE2K FURIN KBTBD13 TGFBR1-1 MAN1A2 UBE2Q2 H2BC18 MAN1C1 TGFBR2 MAN1A1 UBE2R2 BECN1 RRAGA ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 RAB32 ASB16 RAB31 FBXL20 IDE RAB38 ASB10 RAB21 VHL CHML FBXL19 FBXL18 FBXL15 APC FBXL16 FBXL13 FBXL14 RAB39A FBXL12 RAB39B ASB8 RAB18 ASB9 ASB6 MVD ASB7 SEC23A ASB4 SAR1B ASB5 ASB2 ASB1 CISH SOCS2 MBTPS1 SEC24B SEC24A TADA3 SEC24D-1 SEC24C PNPLA2 CTBP1 KDELR1 TRAF2 UFD1 DCTN6 DCTN5 DCTN4 BIRC2 BIRC3 CAPZA3 PRKN ACTR10 RIPK1 OGT-1 DNMT3B DNMT3A DNMT1 NPLOC4 HNRNPK WDR48 POLB UBE2B DDB1 CUL4A DTL RAD18 CUL4B ASPH FCGR3A;FCGR3B NLRP3 TOMM70 PDIA3 MDM2-2 TRIM27 USP13 TNKS IGFBP7 TNKS2 RNF146 CBX8 OTUD3 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM4 BMI1 CCNA2-1 SMC5 RING1 SMC6 DDX17 NSMCE3 NSMCE2 CCNA1 NSMCE1 MRTFA EID3 ZBED1 RNF2 UBA2 SAE1 TOP2A TOP2B ZNF131 SENP5 SENP2 SAFB SENP1 NSMCE4A TOP1 CDKN2A SP100 UHRF2 SATB1 CASP8AP2 NOP58 RWDD3 MBD1 AREG NSF EEF1A1 GRIA1 EEF2 ADAM10 MUL1 DPP3 C3-1 LOC110384692;C4A;C4B_2;C4B UBXN7 ALPG;ALPP;ALPI-1 COP1 RIPK2 USP14 NOD1 NOD2 ST6GALNAC2 PRKCSH TNIP2 MGAT4A-1 USP18;USP41 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 CAMKMT ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 CCP110 ARF4-1 CSNK1D MDC1 GATA3 CETN2 ACTR1A ACTL6A RAB8A RAB8B DDB2 RAB4A RAB33A RAB33B-1 RAB11B RAB35 RAB7B SPP1 USP9X DMP1 LGALS1 AMELY;AMELX EVA1A CCN1 CHGB DCTN2 IGFBP5 IGFBP4 DCTN3 SHISA5 MXRA8 SPARCL1 SCG2 STC2 AMBN FUCA2 GBF1 YY1 TMEM132A BPIFB2 HRC RAB11A MELTF MIA3 MSLN PRSS23 BMP15-1 SYVN1 MEPE RCN1 APOL3;APOL4;APOL1;APOL2 ENAM AMTN VWA1 FAM20C FAM20A MATN3 ITIH2 AFP KDM1B FSTL3 SERPIND1 GOLM1 NUCB1 NOTUM FOXO4 SOCS3 ATXN3 TRRAP NAPA NAPB FBXO32 NAPG TGOLN2 USP34 TFAP2E;TFAP2B PTEN RAB6A RAB6B COG8 COG7 COG6 COG5 COG4 RABGGTB COG3 RABGGTA COG2 COG1 RAB9A RAB9B LHB PENK TRIM28 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 AMFR RNF103 TRIM13 L3MBTL2 TGFA APOE SATB2 DDX5 SMAD2;SMAD3 TFAP2C SPTAN1 CAPZB ANK2 ANK3 CHD3 ANK1 SPTB CAPZA1 CAPZA2 AURKA TIMP1 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 USP15 LTBP1 UCHL5 PSMD8 PSMD6 USP8 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 CHM PSMD14 PSMD13 CUL1 BCL10 UBE2D3-1 RELA PSMA7 ING2 PSMB6 PSMB7 PSMB4 PSMB5 RAB3A PSMB2 PSMB3 PSMB1 RPS27A NCOR2 UBB;UBC KAT2B KAT2A ADRM1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RUVBL1 NFRKB PIAS4 ACTR5 HDAC4 PIAS3 RAD23A UBE2I PCGF2 THRB ACTR8 VDR NR1H2 RORA RAD23B INO80C NR3C1 HIPK2 INO80B ESR1 INO80E NR2C1 INO80D NR3C2 PIAS1 COPS7B NR4A2 COPS7A NR5A1 AR XPC RXRA TFPT MCRS1 SUMO1 SUMO3 INO80 SUMO2 COPS3 RARA COPS6 PPARG PGR PPARA COPS8 MEN1 IGFBP1 BRCA1 USP7 IGFBP3 USP2 USP10 MANEA BLM PCNA WRN MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS36 MRPS33 MRPL18 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 LOC107987373;MRPL23 MRPL30 GFM2 MTRF1 MTRF1L MRRF MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses TYK2 JAK1 IFNAR1 IFNB1-4 ELOC-1 RPS27A STAT2 UBB;UBC EIF2AK2 IRF3 ELOB CUL5 RBX1 EP300 DDX58 IFIH1 MAVS TRIM25 UBA52 CREBBP GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis PITPNB MBOAT1 ETNPPL ETNK2 PLD1 ETNK1 PNPLA3 CSNK2A1;CSNK2A3 PLA2G4A GPAT2 DGAT2 AGK DGAT1 GPD2 LPIN1 LPIN2 LPIN3 MGLL PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 LCLAT1 AGPAT2 PLA2G2A-1 AGPAT3 AGPAT4 PLD2 GPAT4 LIPI ACP6 LIPH AGPAT5-1 GPAT3 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLD3 PLA2G12A PLA2G2E MIGA2 MIGA1 PLA2G4D DDHD2 GPD1L-1 DDHD1 GNPAT CDS1 PITPNM1 LPCAT4 GPD1 PITPNM3 PLA2R1 PLD4 PITPNM2 CDIPT STARD7 MBOAT7 PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E HADHA HADHB-1 PNPLA8 MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 ACHE BCHE SLC44A5 SLC44A3 SLC44A4 PTDSS2 SLC44A1 PTDSS1 SLC44A2 AWAT2 CHAT GPAM PNPLA2 ALPG;ALPP;ALPI-1 CSNK2A2 CSNK2B LPGAT1 CPNE7 CPNE6 CPNE3 PCYT2 PISD PLA2G15 PGP PCTP PLA1A CEPT1 MFSD2A ABHD4 PGS1 PCYT1B PTPMT1 CHKB OSBPL8 PCYT1A OSBPL5 CHKA STARD10 DGAT2L6 ABHD3-2 CRLS1 PHOSPHO1 CDS2 PEMT OSBPL10 TAZ PLAAT1 CHPT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 SELENOI PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK6 KCNJ14 KCNK7 KCNK1 KCNK2 KCNK5 KCNK3 KCNK12 KCNK15 KCNJ2 KCNK9 KCNK4 KCNJ12;KCNJ18 KCNJ4 KCNK10 KCNK13 KCNK16 KCNK18-1 KCNK17 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks ATM KPNA2 MRE11 KAT5 RAD50 NBN INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic NAPA GOLIM4 STX5 CYTH3 YKT6 NAPB CYTH2 CYTH4 MAN2A2 GOLGA5 SNAP29 STX16 CYTH1 ALPG;ALPP;ALPI-1 NAPG MAN2A1 RAB30 RAB36 GOSR2 VTI1A STX6 NSF RAB39A COG8 BET1L COG7 RIC1 ARF1 COG6 CUX1 COG5 COG4 COG3 COG2 COG1 TRIP11 RGP1 GOSR1 MAN1A2 MAN1C1 MAN1A1 VPS45 RAB33B-1 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases FTO ALKBH5 ALKBH2 ASCC1 ASCC2 ASCC3 ALKBH3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling HBEGF NRG2 NRG3 NRG4 PIK3R1 PIK3CA NRG1 EREG BTC PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR PDHB DLD PDHX PDHA1 DLAT SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism SLC34A2 SLC34A1 ABCA3 SFTPD CKAP4 ADRA2C ADRA2A TTF1 ADORA2B ADORA2A P2RY2 SFTPB ZDHHC2 NAPSA CCDC59 GATA6 ADA2 PGA4;PGA3;PGA5 ADGRF5 LMCD1 CSF2RB CTSH CSF2RA SFTPC MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins ISCU CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import ABCD2 PEX19 ABCD3 PEX3 SLC25A17 PEX16 PEX11B ATAD1 PEX2 PEX12 PEX13 PEX14 GDAP1 ACBD5-1 FIS1 PEX26 PXMP2 PXMP4 ABCD1 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling BRAF PPP1CC MRAS ARAF SHOC2 RAF1 YWHAB PPP1CB DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis VCAN CHST15 CHST14 CSPG5 CSPG4 NCAN UST DSE BGN DCN BCAN DSEL SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma HBA2;HBA1 CD163 LRP1 HBD;HBB HPX AMBP ALB HP;HPR APOA1 JCHAIN APOL3;APOL4;APOL1;APOL2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis MAPK8 YWHAH BID CDKN2A PPP3R1 BAD CASP9 YWHAE AVEN DIABLO-1 YWHAZ UACA BCL2 STAT3 BCL2L1 NMT1 BCL2L11 TP73 APIP CASP7 CASP3 TP53 E2F1 TP53BP2 TFDP1 TFDP2 YWHAB MAPK1 MAPK3 YWHAG CASP8 PMAIP1 AKT2 TP63 SFN GZMH;GZMB-1 AKT3 AKT1 PPP1R13B YWHAQ APAF1 BBC3 PPP3CC XIAP CYCS-1 BMF BAK1 GSDMD C1QBP BAX GSDME CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation RPL34 EIF3F RPL10A EIF3D RPL8 EIF3A RPL9 EIF3B RPL6 RPL7 RPS15 RPS14 RPS17 EIF5 RPS16 EIF5B RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 EIF4EBP1 EIF4E EIF4B EIF4G1 UBA52 RPS27A EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M RPL4 EIF3K RPL30 EIF3L RPL3 EIF3I EIF3J RPL32 EIF3G EIF3H RPL31 EIF3E DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis MAPKAP1 MTOR ATG14 BECN1 MLST8 PIK3R4 RIPK1 NFKBIA TAOK1 RICTOR DAXX RPTOR RETREG1 NFKBIB PRR5 PIK3C3 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF22 COPZ2 KIF26A COPZ1 CENPE KIF12 NSF USE1 KIF19 KIF13B KIF1C KIF21A GBF1 KIF1B KIF21B ARF1 KIF1A KIF25 KIF6 KIF27 RINT1 KIF9 ARF4-1 KIFC2 KIFC1 KIFAP3 KIF16B KIF20B NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF5B KIF5A TMED3 TMED7 TMED9 ARFGAP2 KIF3B KIF3A ARF5 COPG2 COPG1 COPB2 TMED2-1 NAPA COPA ARCN1 KDELR3 NAPB COPB1 KIF3C COPE ZW10 KDELR1 SEC22B NAPG KDELR2 RAB1A TMED10 RAB1B KIF4B;KIF4A RACGAP1 KIF18A ARFGAP1 KIF20A KLC1 KLC4 ARFGAP3 KLC3 KLC2 KIF11 KIF15 KIF2A KIF2C KIF23 KIF2B INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins NFASC SCN2A SCN2B SCN11A SCN9A NRCAM SCN5A SPTAN1 SCN1B SCN1A ANK2 ANK3 ANK1 SPTB SCN10A SCN8A KCNQ2 KCNQ3 SCN4A SCN4B SPTBN4 SPTBN5 SPTA1 SCN7A SCN3B SCN3A SPTBN1 SPTBN2 L1CAM MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 HAUS8 HAUS7 PCNT OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP250 CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B TUBGCP2 MZT2A;MZT2B TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 NUMA1 TUBG2 NME7 MZT1 HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CEP57 CETN2 CEP164 ACTR1A MAPRE1-1 CNTRL CEP290 CKAP5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK6 KCNK7 KCNK1 KCNK2 KCNK10 KCNK3 KCNK9 KCNK4 KCNK13 KCNK16 KCNK18-1 KCNK17 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair POLD2 RBBP8 ATRIP BARD1 PPP4R2 XRCC2 TIPIN XRCC3 TIMELESS RPA1 BRCC3 RPA2 PPP4C PALB2 CLSPN SLX1A;SLX1B TP53BP1 POLE4 BABAM1 RAD50 BABAM2 RAD51 UIMC1 RPA3 ABRAXAS1 POLE2 RNF8 POLE3 RAD17 RNF168-1 ATM NSD2 RAD52 RAD1 RAD9B RAD9A ATR H2BC5 XRCC1 LIG3 H2BC1 POLQ MDC1 CDK2 H2BC21 PARP1 UBE2V2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 LIG1 CCNA2-1 CCNA1 SIRT6 RNF4 UBA52 RPS27A UBB;UBC SEM1 PIAS4 PARP2 UBE2I SUMO2 ERCC4 ERCC1 MUS81 MRE11 BRCA1 BRCA2 KAT5 EME2 EXO1 CHEK1 POLK NBN TOPBP1 POLE POLH GEN1 RFC5 RMI2 RFC3 RFC4 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RMI1 FEN1 RFC2 TOP3A HUS1 ABL1 SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 RTEL1 BLM C1orf112 EME1-1 PCNA RAD51AP1 POLD3 POLD4 HERC2 WRN BRIP1 SLX4 FIGNL1 UBE2N POLD1 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE PCCA MMAA PCCB MMUT DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation HGF MET MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins PPP1CA PPP1CC KPNB1 SPCS3 SPCS2 CSNK2A1;CSNK2A3 XPO1 SPCS1 FURIN SEC11A SEC11C CSNK2A2 CSNK2B PPP1CB PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 FZR1 FBXO5 CDK1 CDC20 PLK1 CCNB1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L CCNT2-1 SUPT5H TCEA1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 CCNK CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H CTDP1 POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production SMPD3 SMPD2 TNFRSF1A NSMAF TNF RACK1 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism SLC25A13 ASNS GOT1-1 GOT2-1 GADL1 FOLH1B;FOLH1 NAALAD2 SLC25A12 NAT8L ASPA SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1-1 SP1 MAPK1 E2F4-1 MAPK3 CDK9 CCNT2-1 CDKN2B SMAD2;SMAD3 SMAD4 CCNC-1 MYC MEN1 SMAD7 UBA52 HDAC1 COL1A2 YBX1 TGIF2 CCNK CCNT1 RBL1 WWTR1 RPS27A UBB;UBC SERPINE1 EP300 E2F5 FURIN JUNB TFDP1 RNF111 CDK8 TFDP2 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation MAP2K2;MAP2K1 PTPN11 JAK2 TYK2 IL6 JAK1 MAPK3 CDK1 IL6R RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor HRAS CAMK2G DLG1 DLG3 DLG4 ACTN2 GRIN1 GRIN2D DLG2 RASGRF2 CALM3;CALM1 RASGRF1 NEFL GRIN2B CAMK2B CAMK2D CAMK2A NRAS EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere POLD2 TERF2IP RPA1 RPA2 ACD FEN1 LIG1 RPA3 TERF1-1 DNA2 BLM PCNA POLD3 POLD4 TINF2 WRN TERF2 POLD1 POT1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation NR1H2 RPS27A PCSK9 AP2S1 UBB;UBC AP2A1 AP2A2 AP2M1 MYLIP NR1H3 AP2B1 UBA52 CLTC VLDLR CLTA LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis RAC1 VAV1 HCK ELMO1 CYFIP2 WIPF1 WIPF2 WIPF3 BTK NCKIPSD FCGR3A;FCGR3B VAV3 MYH9 MYO5A ARPC4 ARPC5 PTK2 ARPC2 ARPC3 MAPK1 ACTR3-1 ARPC1B VAV2 ARPC1A WASL MAPK3 ACTR2 SYK FGR ACTB-1 NCKAP1 WASF1-1 WAS CDC42 CRK ACTG1 NCK1 FYN WASF3 MYO10 CYFIP1 MYO1C NCKAP1L WASF2 LYN MYO9B ABL1 BAIAP2 YES1 ABI2 ABI1 ELMO2 CD3G DOCK1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab CDC37 HSP90AA1 ERBIN ERBB2 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs ALOX5 PTGS2-2 ALOX15 EPHX2 HPGD LTA4H CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 LTC4S CYP1A2 CYP1A1 GSTM4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ALOX12 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination TEAD1 DAG1 EGR2 PRX LAMA2 MAG DRP2 NAB1 NAB2 SCD5 MPZ LAMB1 LAMC1 SOX10 HDAC2 POU3F2 YAP1-1 ADGRG6 HMGCR SMARCA4 PMP22 SREBF2 POU3F1 WWTR1 UTRN MBP CYP51A1 ADGRV1 SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK PTN PIK3CB ALKAL2 PRDM1 ALKAL1 MDK FRS2 IRS1 PIK3CA SIN3A PTPRZ1 ALK HDAC2 MYC PLCG1 STAT3 HDAC1 HDAC3 PIK3R2 PIK3R1 PTPN6 HIF1A MYCN CD274 IL2RG EP300 DNMT1 JAK3 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles PSIP1 BANF1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance TTF1 UBTF H2AJ MBD3 POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H GATAD2B TAF1D GATAD2A HDAC2 TAF1B TAF1C TAF1A H2BC5 HDAC1 H2BC1 MTA1 MTA3 H2AC4 KAT2B KAT2A GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2E POLR1C POLR2F H2BC21 POLR1D POLR2H RRN3 MAPK3 POLR2L ERCC6 GTF2H1 H2AZ2;H2AZ1 GTF2H3 GTF2H4 CDK7 ERCC3 ERCC2 MNAT1 EHMT2 H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CHD4 CHD3 CBX3-1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA2 H2AC20 TBP H2AB2;H2AB3;H2AB1 MBD2 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling TAB2 CLEC7A TAB1 CARD9 PSMD8 IKBKB PPP3CA PSMD6 PPP3CB PSMD7 PSMD2 PSMD3 PSMD1 IKBKG PPP3R1 BTRC NFATC3 MAP3K7 NFATC2 SKP1 NFATC1 CHUK CALM3;CALM1 FBXW11 PSMC2-1 PSMA5 PRKCD PSMA6 PSMA3 PSMA4 PSMA1 UBA52 UBE2D1 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PYCARD PSMA7 AHCYL1 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 NFKB2 PSMC6 PSMC3 PLCG2 PSMC4 PSMC1 ITPR1 MAP3K14 ITPR2 ITPR3 SYK PDPK1 CASP8 RELB IL1B UBA3 CDC34 TRAF6 UBE2V1 UBE2D3;UBE2D2 UBE2N TAB3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PTS GCHFR CALM3;CALM1 DHFR2;DHFR HSP90AA1 PRKG2 SPR AKT1 GCH1 NOS3 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity NCOR1 CAMK2G TBL1XR1 AURKB HTT HIPK2 SIN3A LBR AGO3;AGO1 CALM3;CALM1 HDAC2 FOXG1 HDAC1 TNRC6A-1 TNRC6C HDAC3 TNRC6B PRKACA-1 NCOR2 MOV10 AGO4 CAMK4 AGO2 CAMK2B GPS2 CAMK2D CAMK2A NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway TNFAIP3 TAB2 TAB1 CARD9 CYLD IKBKB MAPK14 NOD1 NOD2 MAPK12 IRAK2 MAPK13 IKBKG MAPK11 CASP8 MAP3K7 IRAK1 CASP1 CHUK CASP9 CASP2 MAP2K6 BIRC2 BIRC3 RIPK2 CASP5;CASP4 ITCH TRAF6 UBE2V1 AAMP UBE2N TAB3 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling STAT5A STAT5B JAK1 STAT4 IL21R STAT1 IL21 STAT3 JAK3 IL2RG COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism MMAB MMACHC MMADHC MMAA MTRR MMUT MTR-1 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses TAB2 TAB1 ATG14 JAK1 NOD1 NOD2 IRAK2 KPNA2 TRAF3 IKBKE STAT1 TLR8 TLR7 MBL2-1 MASP1 ISG15 LARP1-1 IRF7 NLRP3 STING1 NUP107 TYK2 IFNAR1 TOMM70 HSP90AA1 IL17RC IL17RA TLR1 TLR2 HSP90AB1 STAT2 IRAK1 NUP160 NUP85 PTPN11 PTPN6 SEC13 NUP133 CREBBP BECN1 NUP43 IKBKB IFNB1-4 IKBKG RANBP2 MAP3K7 CHUK NUP37 SEC23A SAR1B SEC24B SEC24A TKFC SEC24D-1 SEC24C G3BP1 G3BP2 PIK3R4 TBK1 IRF3 DDX58 NUP205 IFIH1 NUP188 RNF135 SIKE1 AAAS MAVS TRIM25 NUP42 NUP62 TPR B2M NUP88 PIK3C3 RAE1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NDC1 NUP214 SFTPD NUP210 NUP155 NUP153 NLRP12 NUP93 NUP50 IL17F POM121;POM121C IL17A NUP35 NUP54 RIPK2 TRAF6 UBE2V1 CNBP-1 UBE2N TAB3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate SRD5A3 DHRSX DOLK DOLPP1 MVD DHDDS NUS1 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation NFATC2 NFATC1 CALM3;CALM1 AHCYL1 PPP3CA PPP3CB ITPR1 ITPR2 PPP3R1 NFATC3 ITPR3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 KCNJ2 KCNJ3 KCNJ12;KCNJ18 KCNJ4 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 KCNJ9 KCNJ15 KCNJ16 GNG13 GNGT1 GNG10 GNB2 GNG2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation RPA1 RPA2 POLE4 H2AJ RPA3 POLE2 POLE3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 H2BC5 UBE2D1 ANAPC10 ANAPC11 H2BC1 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 H2AC4 KPNB1 ANAPC2 FZR1 CDK2 H2BC21 H2AZ2;H2AZ1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 CDC45 MCM7 MCM3 MCM4 MCM5 MCM6 MCM2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CDC7 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDC6 H2AC14 KPNA1 POLE GMNN KPNA6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDT1 MCM10 ORC5 ORC4 DBF4 ORC6 ORC1 MCM8 ORC3 H2AC20 ORC2 H2AB2;H2AB3;H2AB1 PRIM2 PRIM1 POLA1 POLA2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGF4 FGF9 FGF20 FGF23 FGF16 FGF18 FGFR3 FGF1 FGF2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins CCDC88C DVL1 DVL2 DVL3 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli RPA1 RPA2 PALB2 RAD50 SIN3A RPA3 ATM ATR ANAPC15 PRKCD ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 HDAC6 ANAPC11 CDC23 EIF2AK1 UBE2S ATF5 CDC26 CDC16 HSP90B1 CDC27 TXNRD1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 GRB10 CTNNB1 CITED2 COX7A2L-1 MAPK1 MAPK3 MAPK14 MAPK11 COX7A2 MAPKAPK3 MAPKAPK2 PREB SHC1-1 GOSR2 ATF2 SLC46A1 SEC31A CRTC2 SMARCD3 CRTC3 HDAC3 CHD9 CRTC1 LY96 HBD;HBB BACH1 NPAS2 ARNTL HELZ2 RAI1 PGRMC2 HSPD1 XPO1 TGS1 NRIP1 EP300 HMOX1 CLEC1B OMA1 APOB PPARGC1A PECAM1 MEF2D ITGB3 NCOA1 MED1 NCOA2 MEF2C CREBBP NCOA6 APOA1 NR1D1 SIRT1 HBA2;HBA1 NCOR1 TBL1XR1 CARM1 MAFK TLR4 CLOCK NFE2L2 TLN1 VCL STIP1 CALM3;CALM1 YWHAE JUN SOD2 FOXO3 LMNB1 PRDX2 CAPNS1 CAPNS2 TCIRG1 PRDX1 CAPN2 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 NOTCH1 RBX1 ATP6V1B2 ATP6V0D1 ATP6V0D2 ADD1 ATP6V0C ABCG2 ATP6V1B1 SRPRB-1 ATP6V1A FKBP14 ADM HERPUD1 MYDGF PKN2 TATDN2 GNGT1 CREB3L4 ATP6V1H CREB3L1 ATP6V1G3 CREB3L2 TSPYL2 ATP6V1D DDX11 HMOX2 ATP6V1C1 EDEM1-1 ATP6V1C2 WIPI1 PDIA6 PDIA5 ATP6V1F ERN1 DCSTAMP CREB3 GNAS-1 CTDSP2 ATP6V0E2;ATP6V0E1 KDELR3 ATF6B DCTN1 CEBPG CXXC1 EXTL1 SSR1 RAMP2 DNAJB9 CALCRL KLHDC3 ZBTB17 WFS1 ASNS YIF1A CREBRF SRPRA HDGF TPP1 EPO CA9 GNG10 HIGD1A GNG2 GNG5 GNG4 KDR GNG8 PTK6 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 CUL3 CREB3L3 RB1 PRKACB-1 CDKN1A CDKN1B FZR1 E2F1 E2F2 E2F3 SKP2 TFDP1 CDK6 TFDP2 CCNE2 ALB CDK4 P4HB CCNE1 CDK2 IDH1 NUP107 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 TALDO1 HSPG2 NUP160 NUP85 CACNG7 RPS27 PPP2CB;PPP2CA SEC13 NUP133 PPP2R5B DYNC1I2 NUP43 DYNC1I1 TKT RANBP2 DYNC1H1 EXTL2 EXTL3 STOML2 NUP37 PHB2 YME1L1 PGD TXN2 H2AC14 AKT2 MYC AKT3 AKT1 CSNK2A2 CSNK2B TRIB3 ATF3 HSPA5 EPAS1 MAPKAP1 PIK3R2 HIF1A ABCC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MOV10 AGO4 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 FOS H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 RICTOR IKBKE SUZ12 H2BC5 STAT1 STAT3 H2BC1 VCP-1 ATP7A H2AC4 GSK3A PRR5 GSK3B PIK3CD PIK3CB H2BC21 MLST8 NRF1 DELE1 EED HTRA2 PDPK1 DNAJA4 H2AZ2;H2AZ1 LONP1 PIK3CA DNAJA1-1 PRKAA2 PRKAR1A EIF2AK3 RBBP4 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN RBBP7 TNRC6A-1 JMJD7-PLA2G4B;PLA2G4B MTOR TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B ELOC-1 ELOB FLT4 GJA1 MT2A MT3 DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 HIF3A TP53 GNA11 GNAQ NUP205 NUP188 AAAS NUP42 NUP62 TPR ITGB1 NUP88 RAE1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 PANX1 RPL4 RPL30 RPL3 CALR-1 RPL32 HSPA1A;HSPA1B RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 HSPE1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 FABP1 RPL29 RPL28 RPL10;RPL10L-1 CACNA1H DEFA6;DEFA4;DEFA5 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 PIEZO1 RPLP1-2 RPLP0 ITGAV ANXA2 PTK2 PPP2R2A;PPP2R2D RPS4X RPL7A RPLP2 RPL36-1 HSP90AA1 RPS3A CUL2 ACADVL DNAJC3-1 RPL13A-1 RPL11 PRKAR2A RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 AJUBA GFPT1 SQSTM1 HSPA8 TRPV4 P2RY2 KEAP1 UBE2D3;UBE2D2 TRIM21 RPS6KA1 AMER1 ID1 GSTA3;GSTA1 HSP90AB1 CUL7 ARFGAP1 RPTOR RRAGA MAP1LC3B2;MAP1LC3B-1 RRAGC RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VHL MTF1 MBTPS1 HYOU1 NFYB NFYC SP1 NFYA-1 MBTPS2 NCF1 NCF2 NCF4 IL1A CYBB UFD1 CYBA CSRP1 SNCB DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 CYCS-1 DNAJB11 NPLOC4 HSPA9 BAG2 ADCY9 PRKACA-1 PRKAR1B PRKAR2B CAMK2B CAMK2D CAMK2A DNAJA2 NLRP3 CAMK2G ADCY4 ADCY3 ADCY2 ADCY1 EHMT2 ADCY8 EHMT1 ADCY7 ETS1 ETS2 ADCY6 RPS6KA3 ADCY5 RPS6KA2 MAP3K5 MAP2K3 MAP2K4 TINF2 ERF P2RX7 MAPKAPK5 TNIK ASF1A MDM2-2 TXN SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 EP400 IGFBP7 MAP2K7 MAP2K6 CBX8 CBX6 PHC2 ACD PHC1 CBX4 CBX2 HMGA2 H1-0 PHC3 H1-3 H1-2 H1-5 H1-4 IL6 MDM4 CXCL8 BMI1 CABIN1 CCNA2-1 KDM6B RING1 MINK1 TERF2 CCNA1 POT1 TERF2IP CEBPB RNF2 HIRA MAPK9 MAPK8 MAPK7 UBN1 MAP4K4 CDKN2D CDKN2B IFNB1-4 CDKN2C CDKN2A MAPK10 TERF1-1 EGF BCL2 PDGFA AREG BCL2L1 EEF1A1 ERO1A AQP8 NUDT2 SESN1 MUL1 ATF4 CCL13;CCL2 ABCF2-H2BE1;ABCF2 DPP3 PRDX3 STAP2 PRDX6 GCLC MAFG NOX5 GCLM SRXN1 CHD6 ME1 UBXN7 ABCC3 GPX1 GPX6 GPX5 GPX8 GPX7 BLVRB BLVRA HM13 GSTP1 NQO1 TXNRD2 SOD3 ATOX1 SOD1 CCS EIF2S2 EIF2S3;EIF2S3B EIF2S1 FBXL17 PRKCI SLC7A11 CDH5 LMNA ATF6 HSPA1L DDIT3 TXNIP HSPA2 ACTR1A SIRT3 LIMD1 HIF1AN EGLN1 EGLN3 SPP1 EGLN2 WTIP DCTN2 DCTN3 SESN2 SYVN1 COX4I1 COX4I2 ARNT NOS3 ITGA5 PTPN1 NDUFA4 COX7B COX7C COX8A COX8C DCP2-1 COX5B COX5A NOX4 COX6C VEGFA FKBP4 COX6A1 COX6A2 G6PD PTGES3-1 COX6B2 COX6B1 CAPZB CAT CAPZA1 CAPZA2 MMP14 PPP1R15A PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC SKP1 CHUK PSMC2-1 CACNA2D1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 HSPB8 HIKESHI PSMD12 CCAR2 PSMD11 PSMD14 HSBP1 PSMD13 DNAJC2 CUL1 DNAJC7 UBE2D3-1 ST13;LOC107986532 CRYAB RELA PSMA7 RPS19BP1 HSPA4L PSMB6 HSPA14 PSMB7 HSPA13 PSMB4 DNAJB1 PSMB5 BAG4 PSMB2 BAG5 HSPH1 PSMB3 PSMB1 DNAJB6 RPS27A NCOR2 BAG3 HSF1 UBB;UBC CACNB1 BAG1 ADRM1 NFKB1 CACNB2 HSPA4 CACNB3 PSMA2-1 HSPA6 HSPA12A SEM1 HSPA12B NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CHAC1 C12orf66 SZT2 SEH1L NPRL2 NPRL3 RORA GCN1 NR3C1 WDR59 EIF2AK4 ESR1 FLCN NR3C2 MIOS ITFG2 IMPACT DEPDC5 AR KPTN RXRA WDR24 SH3BP4 FNIP1 FNIP2 CASTOR1 CASTOR2 BMT2 PGR PPARA MRE11 IGFBP1 BRCA1 KAT5 NBN FKBP5 ABL1 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency OTC VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CUL5 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 ELOC-1 PSMB1 RPS27A UBB;UBC ELOB ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) MSMO1 HSD17B7 TM7SF2 NSDHL DHCR24 SREBF2 CYP51A1 SREBF1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression TEAD1 HIPK1 TEAD2 TEAD3 HIPK2 NPPA TEAD4 NKX2-5 WWTR1 CCN2 GATA4 KAT2B YAP1-1 TBX5 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PTTG1;PTTG2 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 PLK1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 UBE2S CDC26 CDC16 CDC27 PSMA7 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 RB1 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 CDC20 AURKA PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis IMPDH1 IMPDH2 GART PFAS PAICS ATIC PPAT ADSL ADSS1 GMPS ADSS2 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions BTN2A2;BTN2A1 PPL CLEC4M;CD209-2 XDH BTNL9 BTN3A1;BTN3A3 BTN1A1 BTNL2 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state PSMD8 WDR35 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 GLI3 PSMD13 GLI2 CUL1 OFD1-1 PSMA7 WDR19 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 IFT172 PSMB3 PRKACA-1 ADCY9 PSMB1 PRKAR1B PRKACB-1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 DYNC2H1 SEM1 PSMC5 PRKAR2B PSMC6 PSMC3 RPGRIP1L PSMC4 PSMC1 IFT88 GSK3B KIF3A TTC21B GNAS-1 CSNK1A1 SMO ADCY4 PRKAR2A ADCY3 ADCY2 GLI1 ADCY1 KIF7 ADCY8 GPR161 ADCY7 INTU PRKAR1A TULP3 ADCY6 IFT122 FUZ ADCY5 ADCY10 MKS1 IFT52 NUMB PTCH1 IFT57 ITCH IFT140 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways NUP107 GBP2;GBP3;GBP1 NUP43 RANBP2 KPNA7 KPNA5 KPNA2 NUP205 KPNA3 NUP188 AAAS PABPN1-1 NUP42 NUP62 NUP160 TPR NUP88 RAE1 KPNA1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 KPNB1 KPNA4-1 CPSF4 MLKL EIF2AK2 ISG15 SEC13 NUP133 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases PDZD3 GUCY2C TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GNB1 GNB4 GNB3 GNB5 FLT4 TLN1 VCL CDH5 CALM3;CALM1 RICTOR CAPNS1 CAPNS2 CAPN2 PRKACA-1 ADCY9 PRKAR1B PRKACB-1 CTNNB1 PRKAR2B ADM PKN2 GNGT1 PIEZO1 GNA11 PRR5 PIK3CD PIK3CB MLST8 TRPV4 PDPK1 GNAS-1 PIK3CA ADCY4 PRKAR2A GNAQ ADCY3 RAMP2 ADCY2 CALCRL ADCY1 ADCY8 ADCY7 PRKAR1A ADCY6 ADCY5 AKT1 FYN GNG10 GNG2 GNG5 MAPKAP1 GNG4 MTOR KDR GNG8 PIK3R2 NOS3 P2RY2 MMP14 PANX1 PECAM1 GNG13 GNB2 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHAG RHCG RHBG B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression POLR2E POLR2F POLR1C H2BC21 POLR2H POLR1D POLR2L ERCC6 H2AZ2;H2AZ1 ACTB-1 H2AJ POLR1A DDX21 POLR1B POLR1E POLR1F POLR1G POLR1H H2AC14 TAF1D TAF1B SMARCA5 TAF1C SF3B1 TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYBBP1A H2BC5 BAZ1B H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 KAT2B KAT2A EP300 H2AC20 TBP H2AB2;H2AB3;H2AB1 DEK GSK3B DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells EPAS1 NANOG;NANOGP8 SOX2 ZIC3 SALL4 POU5F1;POU5F1B KLF4 DPPA4 EPHA1 FOXD3 NR5A1 HIF3A FGF2 SMAD2;SMAD3 SMAD4 SALL1 PBX1 TDGF1 PRDM14 STAT3 LIN28A ZSCAN10 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression NOTCH1 NFKB1 EP300 RELA MAFK MYC NFE2L2 CREBBP CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 RPS27A UBB;UBC NOTCH1 UBA52 MIB2 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors MCCC2 MCCC1 SHMT2 PC TTPA LDLRAP1 CUBN AMN APOA2 APOA4 APOE TTR LPL LDLR PRSS3;PRSS2;PRSS1 GPIHBP1 LRAT APOC3 PCCA MMAA LRP10 PCCB MMUT APOC2 LRP12 PARP6 PARP4 RBP4 RBP2 IDH1 PARP16 PARP9 PARP14 RBP1 PARP8 PARP10 MMAB MMACHC MMADHC RETSAT PRKG2 HSP90AA1 AKR1B15;AKR1B10 HSPG2 NT5E RDH11 SDC4 SDC2 BST1 VKORC1L1 SDC3 ST20-MTHFS;MTHFS SLC46A1 ALDH1L1 CTRB1;CTRB2 NADSYN1 PANK4 ALDH1L2 PANK3 FLAD1 PANK1 NUDT12 SLC25A51;SLC25A52 DCAKD SLC52A1;SLC52A2 COASY SLC5A8 PPCDC BTD SLC25A16 SLC5A6 MTHFD1 MTHFD2 VNN1 MTHFD2L SDC1 NUDT8 UBIAD1 VNN2 LRP2 SHMT1 PPCS HLCS PDZD11 PNPO FASN ENPP2 SLC19A3 ENPP1 NADK ENPP3 SLC19A1 SLC25A42 APOB SLC19A2 NAMPT CBLIF AASDHPPT SLC52A3 MTHFR TCN1 CD320 MOCS2 GCH1 STARD7 MOCS3 COQ9 QPRT COQ7 GPHN APOA1 COQ6 THTPA NADK2 PTS COQ5 SLC22A13 CYB5A SLC23A2 NMRK2 GCHFR CYB5R3 RFK HPDL SLC23A1 COQ3 NMRK1 COQ2 NAPRT SPR CD38 ACP5 PDSS2 AOX1 PDSS1 VKORC1 COQ8A SLC25A19 PLB1 PDXK NAXE MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 CALM3;CALM1 NMNAT1 SLC25A32 GPC1 NAXD GPC3 GPC2 GPC5 GPC4 GPC6 AGRN LRP1 LRP8 ACACB ACACA DHFR2;DHFR BCO2 FOLR2 BCO1 MTRR NNMT GSTO1 MTR-1 GSTO2 TCN2 ACO1 SLC2A1 CLPS AKT1 PNLIP APOM ABCC1 ABCD4 NOS3 LMBRD1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants FLT3 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function RBP1 LRAT PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis PPA1-1 LHPP PPA2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism MCCC2 MCCC1 MMAB MMACHC MMADHC ABCD4 PC BTD TCN2 LMBRD1 HLCS ACACA CBLIF PCCA CUBN MMAA AMN PCCB CD320 MTRR MMUT MTR-1 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria HBA2;HBA1 GBP2;GBP3;GBP1 HBD;HBB RPS27A UBB;UBC CALM3;CALM1 CASP5;CASP4 GBP6 GBP7;GBP4 UPK1A EPCAM UBA52 UBE2D3;UBE2D2 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions CACNG8 CACNG2 CACNG3 DLG4 CACNG4 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 STX1A ADAM23 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle TRAK1 RAP1GDS1 MFN1 MFN2 MYO19 TRAK2 RHOT1 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling CASP8 FADD TNFSF10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP10 CFLAR BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression TBL1XR1 CARM1 CLOCK RXRA F7 PPARA BHLHE41 ARNTL2 SMARCD3 NOCT KLF15 BHLHE40 CHD9 NPAS2 ARNTL AVP HELZ2 TGS1 SERPINE1 NAMPT NCOA1 MED1 NCOA2 CREBBP NCOA6 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation PTPN6 CD22 CD79B CD79A LYN REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors FOXO1-1 YWHAQ AKT2 SFN YWHAG AKT3 YWHAZ AKT1 FOXO3 YWHAB FOXO4 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors CES1 HIPK1 NPR1 HIPK2 NPPA NPR2 NKX2-5 NPPC CORIN WWTR1 GATA4 KAT2B MME TBX5 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function ZC3H12A CTNNB1 JUP SOX10 CTNNA1 CTNND1 CDH19 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot SERPINE2 PLAT SERPINB8 PLAU HRG SERPINB6-2 S100A10 SERPINB2 SERPINE1 PLAUR SERPINF2 PLG ANXA2 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly CASP5;CASP4 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 CASP3 PAK2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs TLR3 RELA IKBKB ZBP1 RIPK1 TBK1 IKBKG MYD88 IRF3 NFKB1 NLRP4 DTX4 CHUK NFKBIA TICAM1 NFKB2 RIPK3 NKIRAS1 DHX9 NKIRAS2 NFKBIB BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification ATP6V1H RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking OPTN-1 RAB27B TRAPPC2L TRAPPC2;TRAPPC2B GAPVD1 TRAPPC6A TBC1D20 TRAPPC6B RAB3IP RAB1A RAB1B TRAPPC3 TRAPPC1 TRAPPC4 TRAPPC10 TRAPPC5 TRAPPC9 RABGAP1 GABARAP ARF6 GGA2 ALS2 GGA1 RABGEF1 GGA3 TBC1D13 TBC1D10C SBF2 TBC1D14 TBC1D17 TBC1D10A TBC1D15 TBC1D10B RAB8A RAB8B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B-1 TSC2 DENND1C RAB11B TSC1 DENND1B TBC1D2 GDI1 RABEP1 DENND5B TBC1D7;TBC1D7-LOC100130357 MAP1LC3B2;MAP1LC3B-1 RAB35 DENND1A TBC1D24 GDI2 RINL TBC1D25 TRAPPC12 ULK1 TRAPPC11 RAB7B DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 DENND6B RIN3 RAB38 YWHAE DENND6A RIN1 RIN2 RAB21 ALS2CL CHML CCZ1;CCZ1B ANKRD27 DENND4B DENND4A CHM DENND4C HPS1 HPS4 RAB39A RAB39B TRAPPC8 RAB18 RAB3GAP2 MON1A RAB11A RAB3GAP1 RAB3A MON1B SBF1 AKT2 AKT3 AKT1 RAB5B RAB5C RAB6A RAB5A RAB6B RIC1 RGP1 RAB9A RAB10 RAB14 RAB13 RAB9B RAB27A RAB7A DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I VWF CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding GNB1 GNB4 GNB3 GNB5 CSNK2A1;CSNK2A3 DCAF7 CCT6B PFDN4-1 TUBA1C TUBA1A KIF13A TUBB1 FBXO4 LONP2 FBXO6 RGS9 STAT3 RGS6 RGS7 FBXW4 CCT3 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 TUBA4A XRN2 TCP1 GAPDHS PFDN1 PFDN2 FKBP9 TP53 PFDN5 TUBB3;TUBB6 PFDN6 TUBAL3 GBA GNA14 AP3M1 GNA15 GNGT1 CCNE2 GNA11 CCT8 CCNE1 TUBA3E;TUBA3C-1 CCT7 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B CCT6A TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 GNAQ PDCL SKIV2L FBXL3 RGS11 FBXL5 TUBA8 WRAP53 CSNK2A2 CSNK2B GNG10 GNG2 GNG5 GNG4 GNG8 HDAC3 GNG13 GNB2 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B CYP2R1 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions ATP1B3-1 SLC7A5 SLC7A6 SLC7A7 PPIA MAG SLC7A8 SLC7A9 MMP1 BSG ITGB1 ITGA3 ITGA6 CAV1 SLC3A2 SPN ATP1B2 PPIL2 ATP1B1 SLC7A11 SLC16A1 SLC7A10 SLC16A8 SLC16A3 L1CAM FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) EP400 HIRA UBN1 RB1 HMGA2 H1-0 H1-3 H1-2 H1-5 TP53 H1-4 CABIN1 LMNB1 ASF1A FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling PTPN11 HRAS FRS2 FGF1 FGF2 FGF4 FGF9 SOS1 FRS3 FGF20 FGF23 FGF16 FGF18 NRAS GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER POLD2 RPA1 RPA2 TCEA1 POLE4 RPA3 POLE2 POLE3 ISY1;ISY1-RAB43 UBA52 XAB2 DDB1 XRCC1 LIG3 CUL4A CUL4B RPS27A UBB;UBC RBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D UVSSA AQR ZNF830 POLR2E POLR2F POLR2G PRPF19 POLR2H POLR2I POLR2L ERCC6 GTF2H1 GTF2H3 GTF2H4 ERCC8 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 USP7 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 PPIE LIG1 PCNA POLD3 POLD4 POLD1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases PTPRD SLITRK3 SLITRK5 IL1RAPL2 PPFIA1 IL1RAPL1 PPFIA4 PPFIA3 PPFIA2 NTRK3 PPFIBP1 PPFIBP2 SLITRK2 PTPRS SLITRK1 PTPRF SLITRK4 SLITRK6 LRRC4B AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM PLK1 B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 ERCC6L NUP107 ZWILCH BUB1B PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG DAGLA ABHD6 MGLL ABHD12 DAGLB COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT5 CCT4 TUBB4B CCT6A TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 TUBA8 CCT6B PFDN4-1 TUBA1C TUBA1A TUBB1 CCT3 CCT2 TUBB2B;TUBB2A VBP1 TUBA4A TCP1 PFDN1 PFDN2 PFDN5 TUBB3;TUBB6 PFDN6 TUBAL3 CCT8 TUBA3E;TUBA3C-1 CCT7 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere POLR2E TERF2IP POLR2F POLR2G H2BC21 POLR2H POLR2I POLR2L H2AZ2;H2AZ1 H2AJ POLR2J;POLR2J2;POLR2J3 TERF1-1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 DAXX ATRX POLR2A POLR2B TERF2 POLR2C POLR2D POT1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression SIRT1 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ SUV39H1 RRP8 H2AC20 H2AC14 TBP TAF1D H2AB2;H2AB3;H2AB1 TAF1B TAF1C TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones PNMT DDC TH DBH CAV1 DIO1 DIO3 TXNDC11 SLC5A5 DUOX1 TPO TPH2 TPH1 IYD ASMT DUOXA1 AANAT DUOXA2 CGA TSHB DUOX2 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants JAK2 PIK3R3 HRAS PIK3R2 PIK3R1 LYN PIK3CA YES1 LCK STAT5A STAT5B SOS1 FYN STAT1 KIT STAT3 NRAS UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CAMK2G DLG1 DLG3 DLG4 GRIA3 ACTN2 GRIA4 GRIN2C GRIN1 GRIN2D GRIN2A DLG2 CALM3;CALM1 NEFL GRIN2B CAMK2B CAMK2D CAMK2A GRIA2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane PIK3C2A ARF1 TPTE;TPTE2 PIK3R4 PIK3C2G FIG4 PIKFYVE PI4K2B PI4KB SACM1L PI4KA PI4K2A VAC14 INPP5E OCRL PIK3C3 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F12 KLKB1 F2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) TAS2R39 TAS1R2 TAS1R1 TAS1R3 GABBR2 GABBR1 CASR GRM1 GRM5 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PRH1-TAS2R14;TAS2R14-3 GPRC6A TAS2R7 TAS2R8 GRM3 TAS2R3-1 GRM2 GRM4 GRM7 TAS2R16 GRM6 TAS2R40 GRM8 TAS2R41 TAS2R1 TAS2R42 TAS2R4 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection GNB1 GNB4 GNB3 GNB5 HCK CALM3;CALM1 PLCG1 AHCYL1 CYSLTR1 CYSLTR2 GNAT3 GGT1 PRKACA-1 ADAM17 ADCY9 PRKAR1B PRKACB-1 DPEP2 DPEP1 GNAZ FCGR3A;FCGR3B IL10 PRKAR2B CD163 PLCG2 PLK2 RHBDF2 MYH9 ITPR1 GGT5 GNGT1 ITPR2 ITPR3 SYK GNAS-1 FGR MAPK14 ADORA2B ADCY4 GNAI3 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 PRKAR1A ADCY6 GNAI2 ADCY5 FCGR1A FYN GNG10 GNG2 GNG5 GNG4 GNG8 LYN YES1 IL6 FURIN CD3G GNG13 GNB2 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling PIK3CD JAK2 IL2RB PIK3CB IL2RA JAK1 SYK CSF2 VAV1 PIK3CA HCK RAPGEF1 SOS1 CRK SHC1-1 YWHAZ GAB2 TEC FYN IL2 IL3 PTPN11 PIK3R3 PIK3R2 PIK3R1 PTPN6 LYN PRKACA-1 YES1 IL2RG INPPL1 CBL INPP5D STAT5A STAT5B IL5RA BLNK CSF2RB CSF2RA CRKL JAK3 IL5 IL3RA INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption SLC2A2 SLC2A5 RSC1A1 SLC5A1-1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization VAV2 SYK PPP3CA PPP3CB VAV1 PPP3R1 NFATC3 NFATC2 NFATC1 CALM3;CALM1 SOS1 TEC PLCG1 AHCYL1 GRAP2 LYN BTK TXK PLCG2 ITK VAV3 ITPR1 LCP2 ITPR2 ITPR3 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) SLC6A19 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD5 ENTPD2 ENTPD3 ENTPD4 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping NOXA1 NOXO1 RAC1 WNT5A NOX1 FZD7 MAPK8 DVL1 JUN DVL2 DVL3 CYBA RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling CBFB RUNX1 FOXP3 AXIN1 RSPO3 ESR1 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation MDM2-2 CHEK2 KMT5A RPS27A UBB;UBC SMYD2-1 ATM EHMT2 EP300 TP53 PRMT5 EHMT1 L3MBTL1 MDM4 UBA52 TTC5 SETD9 JMY BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion CCR5 CXCR4 CD4 PPIA ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO KIF3A CSNK1A1 SMO BOC GAS1 CDON PTCH1 DHH GRK2 EVC2 IHH EFCAB7 EVC GAS8 ARRB1 ARRB2 SHH TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 LOC100509620;LOC112267859;AQP7 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production GNB1 GNB4 GNB3 GNB5 GNAS-1 ADORA2B ADCY4 GNAI3 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 PRKAR1A GNAI2 ADCY5 GNG10 GNG2 GNG5 GNG4 GNG8 GNAT3 PRKACA-1 ADCY9 PRKACB-1 PRKAR1B GNAZ IL6 PRKAR2B GNGT1 GNG13 GNB2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 JAG2 JAG1 ADAM10 DLL1 DLL4 ADAM17 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling IL2RB IL2RA STAT5A STAT5B JAK1 PTK2B SHC1-1 SYK IL2 LCK JAK3 IL2RG MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis CASP8 RIPK3 RIPK1 MLKL RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle GARRE1 ARHGAP21 LMAN1 SAMM50 PAK4 VAV1 MCAM ARHGAP39 MCF2 LBR ERBIN MPP7 LAMTOR1 DOCK3 MTX1 PAK1 VANGL1 ARHGAP32 DIAPH3 VAPB TIAM1 ESYT1 PAK2 TFRC CDC42EP4 DEF6 CAV1 ARMCX3 DSG2 VAV3 VAV2 PIK3CA NCKAP1 NCF1 NCF2 NCF4 DOCK10 SYDE1 CDC42 ARHGAP42 BAIAP2L1 GIT1 SWAP70 PLD2 CYBB ITGB1 CYFIP1 CYBA BCR DOCK4 ANKLE2 TRIO ARHGAP17 PIK3R3 ARHGAP1 PIK3R2 ABR PIK3R1 RACGAP1 ARHGAP35 NHS PREX1 SLITRK5 OPHN1 NCKAP1L ARHGDIA WASF2 GIT2 STBD1 ARHGAP26 EMD PGRMC2 ABI2 TMPO TAOK3 ABI1 VRK2 LEMD3 DEPDC1B CDC42EP1 DOCK2 DOCK1 EPHA2 IQGAP1 VAMP3 RAB7A WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL DVL1 PIP5K1B DVL2 DVL3 CSNK2A2 TPTEP2-CSNK1E;CSNK1E CSNK2B CSNK2A1;CSNK2A3 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A FOXO1-1 AKT2 AKT3 AKT1 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions RICTOR IKBKE H2BC5 H2AC16;H2AC11 H2BC1 HNRNPU NEK2 H2AC4 C1S MBL2-1 CTNNB1 CGAS ELAVL1 DHX9 C4BPA C4BPB PRR5 CLU STING1 H2BC21 MLST8 HSP90AB1 UBR4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CPSF7 YBX1 MTOR H2BC15;H2BC3;H2BC11;H2BC12 HNRNPC LY96 VIM RBMX NCBP1 H2BC18 RPTOR APOA1 BECN1 NCBP2-1 TLR4 EXOC1 GBF1 GRPEL1 PQBP1 SRRT SNRNP200 FUS BCAS2 CTNNBL1 PRCC HNRNPA0 HNRNPA3 GPKOW CDC5L CCAR1 CD2BP2 IFIH1 PCBP1 PCBP2 PDCD6IP RBM10 MAVS TRIM25 RETREG1 SUGP1 DHX15 DHX16 FIP1L1 PEX19 HNRNPA2B1 WBP11 HNRNPUL1 PPIE COG1 RIPK1 DDX46 DDX42 RBM17 DYNLT1 BUD31 MMP9 RBM22 DDX23 SMNDC1 U2SURP HNRNPR ATG14 HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 ISY1;ISY1-RAB43 SF3B6 SF3B1 SF3A3 DDX3X-1 SF3A1 SF3A2 XAB2 PHF5A AUP1 CLEC5A TXNL4A SNRPN SNW1 CHERP CPSF4 PTBP1 PLRG1 SNRPA1 DNAJC8 PUF60 SNRPB2 DAXX CAMK2B CAMK2D SNRNP40 CAMK2A PPIL3 PPIL4 PPIL6 SRRM2 DDX5 AQR CRNKL1 PRPF19 CAMK2G HSP90AA1 HNRNPH1 HNRNPH2 STAT2 CWC25 CPSF2-1 PPIL1-1 CWC27 CPSF1 CSTF3 RPL18 EFTUD2 CWC22 CPSF3 CSTF2 PRPF6 CSTF2T HSPG2 WDR33 PRPF8 NUDT21 PABPN1-1 CLP1 PCF11 CWC15 PAPOLA SDC4 SYMPK ELAVL2 SDC2 RBM5 SDC3 SDC1 FASN U2AF1L5;U2AF1 EIF4A3 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 GPC1 TAOK1 SRSF1 GPC3 U2AF2 DHX38 GPC2 SRSF11 GPC5 GPC4 SRSF4-1 GPC6 ALYREF RNPS1 AGRN SNRPD2 TAL1 SNRPD1 TJP1 SNRPD3 HSPA8 NFKBIA SNRPF F2 NFKBIB POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 CTR9 UBE2I POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L LEO1 LOC110384692;C4A;C4B_2;C4B GTF2F1 GTF2F2 PIK3R4 POLR2J;POLR2J2;POLR2J3 H2AC14 PAF1 VTN NRBP1 PIK3C3 MAPKAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription TEAD1 TEAD2 TEAD3 TEAD4 YAP1-1 WWTR1 CCN2 RUNX3 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 CD14 MAP3K8 BTK NFKB2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 PPP2R1B MAPK14 PPP2R1A TLR6 TLR2 MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 SOCS1 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C FGB FGA MAPK9 MAPK8 FGG TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 SIGIRR CUL1 S100A1 CD36 RELA IRAK3 TIRAP RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB S100A9 S100A8 CASP8 RPS6KA5 TRAF2 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling RAC1 TRIO ABLIM1 WASL NTN1 ABLIM2 ABLIM3 SRC CDC42 NCK1 DOCK1 DCC PTK2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors GPR17 LTB4R CYSLTR1 CYSLTR2 PTGDR2 TBXA2R LTB4R2 PTGFR PTGDR PTGER4 PTGER2 PTGER3 PTGIR PTGER1 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) PSTPIP1 CTSG C3-1 TXNIP HSP90AB1 CASP1 NT5E IL18 IL1A P2RX7 IL1B P2RX4 SUGT1 TXN RELA PYCARD C3AR1 ENTPD1 ENTPD5 NFKB1 MEFV GSDMD HMOX1 NFKB2 NLRP3 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction MYBPC3 TPM1 MYBPC1 TNNI3 MYBPC2 ACTN3 TMOD4 TNNC1 TNNC2 TMOD2 NEB MYL4 DES MYH3 TNNT1 MYL1 TNNT2 MYL2 MYL3 TNNT3 MYH8 TCAP MYH6 TMOD3 VIM TTN-1 DMD ACTN2 TNNI1 TPM4 TNNI2 TPM3 TMOD1 TPM2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) POLD2 PARP1 RPA1 RPA2 POLE4 PARG RPA3 POLE2 ADPRS POLE3 MPG OGG1 POLB NTHL1 APEX1 TDG XRCC1 MBD4 LIG3 SMUG1 POLE PNKP NEIL2 NEIL1 RFC5 RFC3 RFC4 RFC1 FEN1 RFC2 LIG1 PCNA POLD3 POLD4 PARP2 POLD1 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins PIAS3 UBE2I NUP107 AURKB TOP2A TOP2B NUP43 TOP1 RANBP2 SUMO1 SUMO3 SUMO2 NUP205 NUP188 CDCA8 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 AURKA SEC13 NUP133 PCNA RANGAP1 INCENP BIRC5 PIAS4 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 MAPK1 RPS6KA1 AP2A1 AP2A2 RPS6KA4 RPS6KA3 DPYSL2 RPS6KA2 AP2M1 RPS6KA5 RPS6KA6 KIF4B;KIF4A DNM1 DNM3 SHTN1 NUMB AP2S1 EZR DNM2 SH3GL2 AP2B1 RDX MSN CLTC CLTA L1CAM RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 CCNK CCNT1 ELL GTF2B AFF4 ELOC-1 MLLT1 TAF7L MLLT3 ELOA SUPT6H ELOB IWS1 NELFB EAF1 NELFA EAF2 NELFCD NELFE SUPT16H TBP NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora GYS1 PPP1R3C GYG1 EPM2A NHLRC1 UBA52 RPS27A UBB;UBC NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR RAN NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 XPO1 SEC13 NUP133 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription MAMLD1 NOTCH2 SNW1 FLT4 NOTCH4 ACTA2 HES5 HEY1 KAT2B KAT2A NOTCH1 MAML2 HEY2 HES1 MAML1 SMAD2;SMAD3 EP300 CREBBP RBPJ PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 SOCS3 PTK6 STAP2 STAT3 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants LRP6 FZD6 RNF43 FZD8 FZD5 FZD4 WNT3A LRP5 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies SI LCT CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine TERF2IP NEIL3 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 ACD H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ TERF1-1 H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 MPG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 TERF2 H2BC1 POT1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils PCOLCE LOX LOXL3 LOXL4 LOXL1 BMP1 LOXL2 TLL2 TLL1 PXDN MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins KPNA7 KPNA5 KPNA2 KPNA3 UBA52 IPO7 NMT1 TUSC3 P4HA1 P4HA2 P4HA3 KPNB1 ACOT2;ACOT1 TMEM258 KPNA4-1 RPS27A UBB;UBC SCAP OST4 SEC11A SEC11C OSTC STT3A HYOU1 STT3B P4HB UBE2I PRKG2 DNAJC3-1 CANX DDOST DAD1 SPCS3 SPCS2 SUMO1 SPCS1 PDIA3 DNAJC10 HSPA5 KPNA1 RPN2 RPN1 DNAJB11 XPO1 DPM1 DPM2 CALR-1 MAGT1 DPM3 APOA1 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling TAB2 HLA-DPA1 PSMD8 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 TRAT1 SKP1 CHUK FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 UBE2D1 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 HLA-DRA PIK3CB PDPK1 PIK3CA LCK HLA-DQB2;HLA-DQB1 PTEN CD4 PIK3R2 PIK3R1 RIPK2 INPP5D HLA-DPB1-1 CDC34 TRAF6 PRKCQ CD3G UBE2V1 CD3E UBE2D3;UBE2D2 CD3D UBE2N NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters CD4 ARF1 LCK CD8B;CD8B2 AP2S1 AP2A1 AP2A2 CD28 AP1G1 PACS1 AP2M1 AP1S2 AP1B1 AP2B1 AP1S1 AP1S3 ATP6V1H B2M AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription RNF2 SALL4 RRAGA RRAGC RRAGB RRAGD SLC38A9 MBD3 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 HDAC5 GATAD2B GATAD2A HDAC2 JUN SUZ12 HDAC1 HDAC7 MTA1 MTA3 SNAI2 SNAI1 MECOM TP53 EGR1 KDM1A MAPK1 MAPK3 MLST8 EED RCOR1 ATN1 MAF1 PPARG RBBP4 RBBP7 ATF2 CHD4 CHD3 NR2E1 MTOR HDAC3 CBX8 CBX6 PHC2 PHC1 MTA2 CBX4 CBX2 REST PHC3 EZH2 BMI1 RPTOR RING1 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic KIF22 KIF26A GOLIM4 STX5 CYTH3 YKT6 CYTH2 CYTH4 GOLGA5 SNAP29 CYTH1 MAN2A1 PLA2G4A KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KIF6 KIF27 RINT1 KIF9 ARF4-1 KIFC2 KIFC1 KIFAP3 KIF16B PLIN3 KIF20B NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF5B KIF5A VPS45 GALNT1 ARFGAP2 KIF3B KIF3A ARF5 TMED2-1 ARCN1 KIF3C DYNC1LI1 DYNC1LI2 ZW10 SEC22B KDELR2 RAB1A TMED10 AGPAT3 RAB1B GOSR2 KIF4B;KIF4A CAPZB KIF18A CAPZA1 ARFGAP1 CAPZA2 ACTR1A GOSR1 MAN1A2 MAN1C1 MAN1A1 KIF2A KIF2C KIF2B RAB33B-1 PAFAH1B1 DYNC1I2 COPZ2 COPZ1 PLA2G6 DYNC1I1 DYNC1H1 CENPE DCTN2 RAB30 RAB36 DCTN3 GALNT2 NSF RAB39A BET1L GBF1 RAB18 RAB3GAP2 ARF1 RAB3GAP1 TRIP11 M6PR TMED3 TMED7 TMED9 COPG2 COPG1 COPB2 COPA NAPA USP6NL KDELR3 COPB1 NAPB SCOC MAN2A2 DCTN1 TMF1 SYS1 COPE STX16 ARL1 RHOBTB3 GCC2 ALPG;ALPP;ALPI-1 GCC1 KDELR1 RABEPK NAPG STX10 TGOLN2 ARFRP1 GOLGA4 VPS51 VPS53 VPS52 GOLGA1 VTI1A STX6 VPS54 ARFIP2 RAB6A RAB6B DCTN6 NAA30 DCTN5 COG8 DCTN4 COG7 RACGAP1 BICD1 BICD2 RIC1 COG6 CAPZA3 COG5 CUX1 ACTR10 COG4 PAFAH1B3 COG3 PAFAH1B2 COG2 COG1 IGF2R RGP1 NAA35 RAB9A NAA38 KIF20A VAMP4 KLC1 RAB9B KLC4 KLC3 ARFGAP3 KLC2 KIF11 KIF15 VAMP3 KIF23 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME ABCC2 CES1 BCHE ABCC3 CYP2D6;LOC107987479;LOC107987478-1 SLC16A1 CYP2C9;CYP2C19 GLYATL3 ACSM5 GLYAT ACSM4 CES2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 BSG ALB ACSM2A;ACSM2B CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 UGT2A1 UGT1A1;UGT1A6 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events MYBL2 LIN54 FOXM1 LIN52 LIN37 LIN9 WEE1 EP300 CENPF RBBP4 CDC25C PLK1 PKMYT1 CDC25A CCNB2 CCNB1 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE GPCPD1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants FLT3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA STING1 ZBP1 RPS27A TBK1 UBB;UBC IRF3 TRIM32 NLRP4 DTX4 DDX41 TRIM56 UBA52 TRIM21 TREX1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX CYP27A1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA NUP107 NCBP2-1 NUP43 EIF4E RANBP2 NUP205 NUP188 NXF1 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 ALYREF NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 NCBP1 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS2 PRPS1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells SLC2A2 NKX2-2 PDX1 PAX6 HNF1A MAFA RFX6 HNF4G FOXA3 FOXA2 IAPP FOXO1-1 AKT2 AKT3 AKT1 GCK INS;INS-IGF2 NEUROD1 NKX6-1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PFKFB2 PFKFB1 PFKFB4 PPP2R5D PFKFB3 PPP2R1B PPP2R1A PPP2CB;PPP2CA PRKACA-1 PRKACB-1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization MMP1 CTSS CTSB BMP7 ICAM1 CDH1 ITGAM SPARC ITGB2 TNC ICAM4 ICAM5 ITGAE COMP IBSP ITGAX ITGB7 ITGAD CD47 HAPLN1 JAM2 TNN JAM3 TNR MUSK ITGA11 FBN1 ASPN PDGFB MATN1 MATN4 TNXB LRP4 PRKCA DSPP VCAM1 SH3PXD2A ADAM15 ADAM12 ACTN1 COL1A1 COL1A2 CTRB1;CTRB2 CTSV;CTSL TRAPPC4 THBS1 FURIN MMP2 PECAM1 ITGB3 PLG MMP13 PXDN FGB FGA CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 FGG SPP1 KLK3;KLK2 DMP1 CAST CAPNS1 CAPNS2 CAPN2 SGCE CAPN1 SGCD SGCA SGCB DMD SGCG SNTA1 DTNA DTNB SGCZ SSPN SNTB1 SNTB2 MATN3 PLEC F11R ICAM2 LOX ICAM3 LOXL3 LOXL4 LOXL1 LOXL2 PHYKPL BSG OPTC KLK7 ITGB1 ITGAL GDF5 DDR1 MMP20 MMP25 KDR MMP24 MMP10 COL17A1 COL18A1 MMP12 MMP11 ITGA4 COL15A1 MMP15 COL16A1 COL13A1 MMP17 MMP19 COL14A1 DDR2 COL11A1 COL12A1 TPSAB1;TPSB2;TPSD1 TMPRSS6 COL11A2 COL19A1 CAPN8 COL10A1 EFEMP2 EFEMP1 PPIB COL28A1 CAPN9 ITGA5 COL26A1 CAPN6 COL27A1 ELANE COL24A1 CAPN7 CAPN5 COL25A1 COL22A1 CAPN3 COL23A1 ADAM9 COL3A1 ADAM8 UTRN COL2A1 FBN2 MMP9 FBN3 COL5A1 COL4A2 CD151 COL4A1 HTRA1 FBLN1 COL7A1 FBLN2 COL6A2 FBLN5 COL5A3 COL4A4 SCUBE3 SCUBE1 COL6A1 COL5A2 MMP8 COL4A3 SPOCK3 COL4A6 NTN4 MFAP5 COL20A1 CAPN13 COL9A1 MFAP4 COL8A2 CAPN14 COL8A1 PSEN1 CAPN11 COL6A3 CAPN12 NCSTN COL4A5 CAPN10 COL21A1 MFAP3 COL9A3 MFAP2 COL6A6 COL6A5 COL9A2 DRP2 CMA1 NCAN BGN DCN BCAN VCAN TTR P4HA1 P4HA2 P4HA3 CTSK ITGB5 TGFB1 ADAM19 A2M PRSS3;PRSS2;PRSS1 ITGAV P4HB CTSD DAG1 CTSG ADAMTS4 ADAMTS5 HSPG2 ADAMTS2 ADAMTS3 ADAMTS1 SDC4 BMP2 SDC2 SDC3 ADAMTS8 ADAMTS9 TIMP2 TIMP1 TGFB2 SDC1 MMP14 ITGA9 SERPINE1 ADAMTS16 MMP16 ADAMTS14 NCAM1 ADAMTS18 LTBP4 LTBP2 LTBP3 LTBP1 ITGA10 ITGB8 ITGB6 TGFB3 ITGA8 CD44 MMP7 BMP1 COLGALT2 PLOD3 TLL2 PLOD2 TLL1 PDGFA PLOD1 COLGALT1 P3H2 P3H1 BMP10 PCOLCE P3H3 CASK AGRN PCOLCE2 SERPINH1 FMOD CRTAP ADAM10 ADAM17 CASP3 KLKB1 PTPRS LAMA5 NRXN1;NRXN3;NRXN2 LAMB3 LAMA2 LAMB2 ITGA2B LAMA1 LAMC3 FGF2 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN BMP4 ITGB4 ITGA3 ITGA2 ITGA1 NID1 NID2 ITGA7 ITGA6 MMP3 ACAN LUM PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events AKT2 PDE3B DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis GYG2 GYG1 EPM2A RPS27A UBB;UBC GBE1 GYS2 UGP2 GYS1 PPP1R3C NHLRC1 UBA52 PGM1 SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste CALHM3 SCNN1G SCNN1D SCNN1B CALHM1 SCNN1A NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions COL4A3 COL9A1 CNTN2 COL6A3 ARTN COL4A5 ST8SIA4 COL9A3 COL6A6 GFRA2 COL6A5 GFRA4 COL9A2 CACNA1C ST8SIA2 NRTN NCAN CACNA1S PRNP GFRA1 PSPN CACNA1D AGRN GDNF CACNA1H CACNB1 CACNB2 CACNA1G CACNB3 CACNB4 CACNA1I NCAM1 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall CD74 SLC7A5 CD84 SLC7A6 VPREB3 SLC7A7 VPREB1 SLC7A8 CXADR SLC7A9 FCAMR IGLL5;IGLL1 JAML GYPC CD99L2 SIRPA;SIRPB1;SIRPG MMP1 GLG1 DOK2 CD99 SELE SELL ESAM TREM1 OLR1 CD48 EPCAM SELPLG CD2 JCHAIN CD244 FCER1G GP6 CAV1 TGFB1 ATP1B2 ATP1B1 ITGAM ITGB2 ITGAX ITGAV CD47 NRAS JAM2 JAM3 PIK3CB HRAS ATP1B3-1 PIK3CA LCK SOS1 SHC1-1 FYN SDC4 SDC2 SDC3 PTPN11 ANGPT1 TEK PTPN6 THBD CD177 PROCR SDC1 SELP MIF INPP5D APOB PECAM1 ITGB3 ANGPT4 ANGPT2 GRB14-1 L1CAM CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 PPIA GRB7 MAG CD44 GPC1 PLCG1 TSPAN7 SPN PPIL2 F2 PICK1 F11R FN1 PROC PROS1 PF4;PF4V1-1 BSG ITGB1 ITGAL MERTK ITGA3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PIK3R2 GAS6 PIK3R1 ITGA4 ITGA6 LYN YES1 ITGA5 SLC3A2 SLC7A11 SLC16A1 SLC7A10 SLC16A8 SLC16A3 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation TERF2IP CTC1 STN1 ACD TEN1 TERF1-1 PRIM2 PRIM1 TINF2 POLA1 POLA2 TERF2 POT1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants FLT3 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE ETNPPL ETNK2 ETNK1 PCYT2 PISD CEPT1 CHKB LPIN1 LPIN2 CHKA LPIN3 PHOSPHO1 SELENOI TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors PRKCG GRIP2 GRIA1 PRKCA TSPAN7 GRIA3 GRIA4 AP2A1 PRKCB GRIA2 GRIP1 PICK1 NSF REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand POLD2 TERF2IP RPA1 RPA2 ACD FEN1 RPA3 TERF1-1 DNA2 PCNA POLD3 POLD4 TINF2 WRN TERF2 POLD1 POT1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins UBE2I NUP107 NUP43 PIAS1 RANBP2 SUMO1 NUP205 NUP188 AAAS NUP42 VHL NUP62 NUP160 TPR NUP88 RAE1 MDM2-2 NUP85 NDC1 TRIM27 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 PML NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 PIAS4 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 PTPN11 PIK3R1 FRS2 KLB PIK3CA FGF1 FGF2 FGF4 FGF6 GAB1 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 FGFR4 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism MAN2B2 MANBA MAN2B1 MAN2C1 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC14A1 SLC14A2 SLC22A3 SLC47A1 RUNX1 SLC25A26 SLC22A15 SLC22A16 SLC22A18 SLC22A5 SLC22A2 SLC22A1 RSC1A1 SLC22A4 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism CHSY1-1 UST CHST3 IDUA HEXB NCAN HEXA DSE BGN GLB1L3 DCN GLB1L2 BCAN VCAN CHST11 CHPF2 GLB1L HYAL1 CHST12 CHST15 GLB1 CHPF HYAL3 HYAL4 CHST13 IDS CHST14 CSPG5 CSPG4 GUSB ARSB CSGALNACT1 CSGALNACT2 CHSY3 CHST7 DSEL THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model UCP1 SLC25A27 UCP3 UCP2 SLC25A14 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation SNAI1 FGFR1 EOMES TBXT AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation NGFR RHOA ARHGDIA NGF CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication CLDN11 RAC1 CLDN10 CLDN15 CLDN14 JAK1 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 FARP2 WT1 MPHOSPH8 H2AJ PVR CDH9 HACE1 CSNK2A1;CSNK2A3 CDH7 AGO3;AGO1 FOXQ1 PRKCSH CDH6 CDH5 CDH3 TLE1 ZBTB33 SOX10 IL6ST SDK1 HDAC2 GANAB PTK2B SDK2 CLDN22;CLDN24-1 PKM SUZ12 CDH10 H2BC5 CDH12 CDH13 STAT3 CDH17 CDH18 HDAC1 H2BC1 CDH19 CTSS PARD6G PARD6B MOGS MCRIP1 CTSB NECTIN4 NECTIN3 KLF4 NECTIN2 NECTIN1 H2AC4 ACTN2 MYCN SNAI2 TMEM258 SRC CTNND1 TWIST2 CDH1 CTNNB1 BANP OST4 EPS15 CBLL1 RNF19B OSTC STT3A ACTN4 CD47 PIK3CB MAPK1 VAV2 H2BC21 MAPK3 EED CLDN5 H2AZ2;H2AZ1 DDOST PIK3CA DAD1 CDC42 RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN RBBP7 ACTN1 TNRC6A-1 PTPN11 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 ARID1A TNRC6B FURIN PCSK6 CDH2 PXN IQGAP1 ZEB1 TRAF7 JAK2 SIRT1 VCL DST KMT5A JUP PLEC SP1 ACTN3 PATJ MPP5 CRB3 ARHGEF4 CTBP2 ARHGEF6 CTBP1 F11R PARD6A PARD3 ITGB1 COL17A1 BIRC2 XIAP FERMT2 CD151 DOCK1 HEYL ELMO1 SIRPA;SIRPB1;SIRPG ARHGAP32 TYROBP FLNA SMARCA4 ANGPTL4 TESK1 PRDM8 CD2AP BHLHE22 RSU1 CDH8 PARVA CTNNA1 PARVB CDH24 RB1 HOXC8 LIMS4;LIMS1 FOXF1 FLNC ADAM33 LIMS2 KIRREL3 ADAM19 KIRREL1 ILF3 KIRREL2 CDH11 SNAI1 MAGI2 SKAP2-2 FBLIM1 ILK SIRPB1 SEC11A NPHS1 SEC11C KDM1A PTK2 TYK2 WASL CANX POMT2 SPCS3 VASP SPCS2 ZNF217 SPCS1 POMT1 TFAP2A NCK2 NCK1 SPTAN1 MDM2-2 ANG ANK3 TGIF2 IL6 SPTBN1 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 TIAM1 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CASK ZEB2 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 PSMC5 PSMC6 DNM2 PSMC3 PSMC4 PSMC1 LAMB3 LAMA3 LAMC2 H2AC14 MYC CLDN1 CSNK2A2 CSNK2B RPN2 CDH4 ITGB4 RPN1 PIK3R2 PIK3R1 ITGA6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDH15 FOXA2 PRKCI IL6R CLDN2 MTBP MOV10 ZC3H12A AGO4 CLDN6 H2AC20 CLDN4 AGO2 CLDN3 CLDN9 H2AB2;H2AB3;H2AB1 CLDN8 EZH2 CLDN7 CADM3 FYB1 CADM1 CADM2 CLDN23-1 PCSK7 CLDN20 ZMYM2 RACK1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres TERF2IP POLD2 RPA1 RPA2 RPA3 TERF1-1 DSCC1 RUVBL2 SHQ1 PIF1 CTC1 CHTF18 STN1 TEN1 RUVBL1 CDK2 PPP6C PPP6R3 WRAP53 TINF2 DKC1 NHP2 ANKRD28 RFC5 RFC3 RFC4 RFC1 ACD FEN1 RFC2 LIG1 DNA2 RTEL1 BLM NOP10 PCNA PRIM2 CCNA2-1 POLD3 PRIM1 POLD4 WRN POLA1 TERT POLA2 TERF2 CCNA1 POT1 POLD1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification LMAN1 STX5 YKT6 MGAT4A-1 TGFA FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST6GAL1 MGAT4C MGAT4B ARF4-1 FUCA1 CSNK1D CGA INS;INS-IGF2 CHST8 ARFGAP2 MCFD2 SERPINA1 PPP6C TFG PPP6R1 ARF5 PPP6R3 CTSC TMED2-1 ARCN1 TRAPPC2L TRAPPC2;TRAPPC2B LMAN1L F5 TRAPPC6A DYNC1LI1 F8 TBC1D20 TRAPPC6B DYNC1LI2 GORASP1 PREB SEC22B SEC22A SEC22C KDELR2 RAB1A TMED10 STX17 LMAN2L RAB1B SPTAN1 GOSR2 USO1 SCFD1 CAPZB LMAN2 CD59 ANK2 SEC31B MIA2 ANK3 SEC31A ANK1 ANKRD28 TRAPPC3 SPTB TRAPPC1 TRAPPC4 TRAPPC10 TRAPPC5 CAPZA1 TRAPPC9 ARFGAP1 CAPZA2 ACTR1A SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 FUT6;FUT5;FUT3 CNIH3 BET1 SEC13 SPTBN4 SPTBN5 SPTA1 GOSR1 MAN1A2 SPTBN1 MAN1C1 SPTBN2 MAN1A1 CHST10 DYNC1I2 COPZ2 COPZ1 DYNC1I1 ST8SIA6 DYNC1H1 ST8SIA2 ST8SIA3 DCTN2 DCTN3 AREG GOLGA2 NSF GRIA1 BET1L GBF1 ARF1 CTSZ MIA3 SEC23A SAR1B GOLGB1 SEC24B SEC24A SEC24D-1 TMED3 TMED7 TMED9 SEC24C COPG2 COPG1 COPB2 COPA NAPA KDELR3 COPB1 NAPB MAN2A2 DCTN1 TMEM115 COPE B4GALT2 B4GALT3 B4GALT1 KDELR1 NAPG DCTN6 DCTN5 COG8 DCTN4 COG7 CD55 COG6 CAPZA3 COG5 ACTR10 COG4 B4GALT6 COG3 COG2 COG1 MGAT3 B4GALT4 MANEA B4GALT5 ARFGAP3 COL7A1 LHB REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation TBX2 HINT1 SIN3A CDKN1A CDKN2A TCF7 LEF1 CCND1 CTNNB1 MET PLK1 TCF7L2 TCF7L1 HDAC1 CDC25B CCNB1 CDK2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ULBP3;ULBP1;RAET1G;ULBP2;RAET1L PVR CXADR COLEC12 CD8B;CD8B2 JAML CD99 TYROBP SELL TREM1 CD22 NECTIN2 ICAM1 CDH1 ITGB2 FCGR3A;FCGR3B CD81 ICAM4 CD300LF;CD300LD ICAM5 SIGLEC10;SIGLEC11;SIGLEC16 KLRC4-KLRK1;KLRK1 LAIR1;LAIR2-1 CD96 ITGB7 PIANP SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 OSCAR CD8A ULBP1-2 CD300E NCR3LG1-1 CD226 CD19 HCST IFITM3;IFITM2;IFITM1 CLEC4G NCR1-1 C3-1 CD1D CD1C VCAM1 CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 SLAMF6 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG KLRG1 NPDC1 SIGLEC5;SIGLEC14 KLRB1-1 ICAM2 KLRC4;KLRC3;KLRC2;KLRC1 ICAM3 CD160 CRTAM SH2D1A FCGR1A SH2D1B PILRA;PILRB CD33-1 TREML1 B2M CD40LG ITGB1 ITGAL TREML4 TREML2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KLRD1 SIGLEC1 RAET1E-1 CD200 ITGA4 CD3G CD3E TREM2 CD3D MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling MTOR RPS6 RRAGA RRAGC RRAGB MLST8 RRAGD AKT1S1 EIF4EBP1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 FKBP1A LAMTOR5 EIF4G1 RPTOR EEF2K EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes SIRT1 MED7 MED20 NCOR1 TBL1XR1 H2AJ PAXIP1 PLIN2 H2BC5 LIPE H2BC1 DGAT2 CDK5 CD36 ANGPTL4 H2AC4 LPL FABP4 RB1 PHLDA1 NCOR2 ACSL1 KMT2C PEX11A PLIN1 LPIN1 MGLL CIDEC GPS2 KMT2D ELOVL5 DPY30 PLIN4 GPAM MED31-1 SCD MED30 H2BC21 THRSP WDR5 NCOA3 PNPLA2 NR5A2 H2AZ2;H2AZ1 RXRA KDM6A H2AC14 CCNC-1 AGPAT2 PAGR1 RBBP5 PPARGC1B ACSS3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AJUBA HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MED16 MED17 CEBPA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MED12 MED14 MED13 ABL1 MED10 EP300 H2AC20 H2AB2;H2AB3;H2AB1 ADIPOQ PPARGC1A NCOA1 MED27 MED1 PDK4 NCOA2 CDK8 ASH2L MED23 CREBBP NCOA6 MED4 MED6 MED24 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling RAC1 KALRN PSMD8 PSMD6 PSMD7 PSMD2 HSPB1 PSMD3 PSMD1 AGO3;AGO1 PAK1 PSMC2-1 PSMA5 PSMA6 PAK3 JUN PSMA3 PAK2 PSMA4 PSMA1 UBA52 FOXO3 PSMD12 PSMD11 PSMD14 PSMD13 CDC42EP5 CDC42EP3 PSMA7 CDC42EP2 CDK1 PSMB6 PSMB7 DNAJB1 PSMB4 PSMB5 PSMB2 PSMB3 PRKACA-1 PSMB1 PRKACB-1 RPS27A UBB;UBC CCND3 ADRM1 FOXO1-1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NCOA3 RAG2 RAG1 CDC42 MYC SEPTIN7 CDC14B MAPKAPK5 ETV4 TNRC6A-1 IGF2BP1 MAPK6 MAPK4 TNRC6C CDC14A TNRC6B XPO1 MOV10 AGO4 AGO2 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL2 OS9 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 GPC5 PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 ADAM17 PSMB1 SYVN1 RPS27A UBB;UBC ADRM1 SEL1L PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 IHH PSMC4 PSMC1 SHH NOTUM P4HB DHH ERLEC1 HHAT DISP2 SCUBE2 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 RAC1 RHOA KTN1 RHOG KLC1 CDC42 KLC4 KLC3 KLC2 KIF5B KIF5A CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA CBL GAB1 SOS1 SHC1-1 PLCG1 EGF NRAS DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown NUP107 NEK9 NEK6 NEK7 NUP43 PRKCA RANBP2 PRKCB NUP205 NUP188 AAAS NUP42 NUP62 PLK1 NUP160 TPR BANF1 LMNB1 NUP88 CCNB2 RAE1 CCNB1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 CDK1 NUP50 POM121;POM121C NUP35 VRK1 NUP54 LEMD2 EMD SEC13 NUP133 LPIN1 LEMD3 LPIN2 LPIN3 CTDNEP1 CNEP1R1 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 NOTCH1 LFNG NOTCH2 NOTCH3 NOTCH4 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones INHA FSHB CGA TSHB INHBB INHBC INHBA INHBE LHB PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer RAC1 VAV1 PDGFRB TRAT1 NTRK3 PIK3AP1 RICTOR TGFA KIT FLT3LG CD86 CD80 SRC CDKN1A CDKN1B FOXO1-1 MET GSK3A PRR5 GSK3B FLT3 PIK3CD PIK3CB PIK3CG PDGFB CD19 MLST8 FRS2 PDPK1 PIK3CA LCK RPS6KB2 STRN ESR2 NR4A1 FYN MDM2-2 PTPN11 MTOR ERBB2 NRG2 NRG3 NRG4 TSC2 AKT1S1 EGFR NTRK2 BDNF CHUK BAD CASP9 GAB1 NTF4 NTF3 EGF FOXO3 EREG AREG BTC EPGN HBEGF NRG1 FOXO4 HGF ESR1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 FGF20 FGF23 AKT3 FGF22 AKT1 GAB2 FGF16 FGF19 FGF18 PTEN FGFR4 FGF10 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 RHOG CD28 PDGFRA COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation CTSD COL9A1 COL9A3 COL9A2 MMP1 MMP7 PHYKPL MMP20 COL17A1 CTSB MMP10 COL18A1 CTSV;CTSL MMP12 COL15A1 MMP11 COL16A1 MMP15 COL13A1 ADAM10 COL14A1 MMP19 MMP3 COL12A1 CTSK TMPRSS6 COL19A1 ADAM17 COL26A1 ELANE MMP14 COL25A1 PRSS3;PRSS2;PRSS1 COL23A1 ADAM9 FURIN MMP2 MMP9 MMP13 MMP8 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex TRRAP H2BC21 CDC73 WDR5 LEO1 H2AZ2;H2AZ1 H2AJ PYGO1 PYGO2 LEF1 BCL9L TLE1 H2AC14 BCL9 MYC MEN1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 H2BC5 TCF7L2 HDAC1 TCF7L1 AXIN2 H2BC1 SMARCA4 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 RUNX3 TCF7 EP300 H2AC20 CTNNB1 H2AB2;H2AB3;H2AB1 TLE4 TLE2 ASH2L TERT RUVBL1 CREBBP TLE3 KMT2B DPY30 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members PSENEN PSEN2 PSEN1 APH1A TRIM33 NCSTN APH1B AGO3;AGO1 UBE2D1 PPP1CB HDAC1 SNW1 PPP1CA MYCN ITGB5 TGFB1 CBL TFDP1 FST TFDP2 FOXH1 DRAP1 ITGAV TGIF1-1 MAPK1 MAPK3 PARP1 PPP1CC ATP1B4 INHBB SMAD2;SMAD3 SMAD1 SMAD4 CCNC-1 SMURF2 SMURF1 SMAD6 SMAD7 BMP2 COL1A2 TNRC6A-1 YBX1 TNRC6C TGIF2 TNRC6B CCNK CCNT1 TIMP2 TIMP1 RBL1 HELLS TGFB2 INHBA KLF16 XPO1 ACVR2A TGFBR3 MMP14 SERPINE1 EP300 MMP16 GIPC1 INHA FURIN TGFBR1-1 ITGB3 JUNB TGFBR2 RNF111 ARRB1 PPP1R15A USP15 LTBP4 LTBP2 ARRB2 LTBP3 MTMR4 LTBP1 ITGB8 PPM1A NCOR1 STRAP PMEPA1 E2F4-1 CDK9 ITGB6 TGFB3 NEDD4L CCNT2-1 UCHL5 BAMBI ITGA8 CDKN2B USP9X FKBP1A SKI UBA52 ACVRL1 BMP10 BMPR2 AMHR2 CHRDL1 UBE2D3-1 FSTL1 AMH NOG GDF2 SMAD9 SMAD5 GREM2 ZFYVE16 BMPR1B BMPR1A TCF12 NCOR2 RPS27A UBB;UBC FSTL3 SP1 ARHGEF18 CGN RXRA F11R FGF2 PRKCZ RHOA RARA PARD6A PARD3 MYC MEN1 ITGB1 MYOG MYOD1 MYF6 TCF4 WWTR1 MYF5 SKIL MOV10 AGO4 AGO2 E2F5 ACVR1C STUB1 CDK8 ACVR1B ACVR2B CER1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR EGFR FAM83B GAB1 TGFA PLCG1 EGF UBA52 AREG EREG BTC EPGN HBEGF ADAM10 SH3GL3 SH3KBP1 ADAM17 SRC RPS27A UBB;UBC STAM CBL HGS STAM2 EPS15 SH3GL2 SH3GL1 NRAS HRAS PTPN12 ARHGEF7 PIK3CA ADAM12 PTPN3 SOS1 CDC42 SHC1-1 CSK SPRY2 PTPN11 PIK3R1 PTPRK EPS15L1 LRIG1 FAM83D EPN1 PAG1 FAM83A SPRY1 PXN AAMP SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling PTPN11 MAPK1 MAPK3 BRAF PPP2R1A PPP2CB;PPP2CA UBA52 RPS27A MKNK1 UBB;UBC SPRY2 CBL E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication CDK1 PPP2R1B PPP2R1A RB1 PPP2CB;PPP2CA ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 E2F1 PPP2R3B PRIM2 TFDP1 PRIM1 POLA1 TFDP2 POLA2 CCNB1 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME NME1 NT5C2 PNP-1 ADA SLC28A2 SLC29A1 SLC28A3 NME2 ADK SLC29A3 ITPA BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement JAK2 RAC1 JAK1 PSMD8 PSMD6 FARP2 PSMD7 PSMD2 PSMD3 PSMD1 ELMO1 VCL HACE1 PSMC2-1 IL6ST PSMA5 TIAM1 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 STAT3 PSMD11 PSMD14 CTSS PSMD13 CTSB RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CTNNA1 PSMB2 PSMB3 SRC PSMB1 CTNND1 RPS27A UBB;UBC ADRM1 CDH1 CDH11 NFKB1 PSMA2-1 SEM1 CTNNB1 JUP PSMC5 PSMC6 CBLL1 PSMC3 RNF19B PSMC4 PSMC1 TYK2 VAV2 ARHGEF4 CDC42 CTSV;CTSL BIRC2 XIAP IL6R IL6 DOCK1 TRAF7 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs ARPC3 MAPK1 RAC1 ACTR3-1 ARPC1B ARPC1A WASL MAPK3 ACTR2 ACTB-1 NCKAP1 WASF1-1 WAS CDC42 ACTG1 NCK1 WASF3 CYFIP1 CYFIP2 WIPF1 WIPF2 WIPF3 NCKAP1L WASF2 ABL1 BAIAP2 ABI2 BTK ABI1 NCKIPSD ARPC4 ARPC5 PTK2 ARPC2 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine GLYATL3 ACSM5 GLYAT ACSM4 ACSM2A;ACSM2B CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily H2BC21 WDR5 MAFK NFE2L2 H2AZ2;H2AZ1 CHD6 DKK2 H2AJ H2AC14 CHD8 CTCF H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NQO1 H2BC5 AXIN2 H2BC1 IGF2 H2BC15;H2BC3;H2BC11;H2BC12 CHD9 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 CHD7 NKD2 FAM124B EP300 H2AC20 CTNNB1 H2AB2;H2AB3;H2AB1 CREBBP DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A RAD51B RAD51D RAD51C DNA2 SEM1 BLM RAD51AP1 WRN BRIP1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion CD36 FFAR1 PLCB3 GNA14 ACSL4 PLCB1 ACSL3 PLCB2 GNA15 GNA11 GNAQ TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK1 IRF7 TRAF6 UBE2V1 TLR9 UBE2N IRAK4 MYD88 TLR7 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) CNOT2 CNOT3 RBBP8 ATRIP ZNF777 BARD1 ZNF775 CNOT8 CNOT9 RPA1 ZNF774 RPA2 ZNF426-1 ZNF772 ZNF771 ZNF770 SIN3B RAD50 SIN3A RAD51 RPA3 ZNF529 LBR DDX21 ZNF75D RAD17 ZFP90 ZNF75A ATM RAD1 ZNF514 RAD9B ZNF750 RAD9A HDAC5 SMARCD1 ATR ANAPC15 HDAC2 ANAPC16 SMARCD2 ANAPC7 RNF34 UBE2C GLS2 NLRC4 UBE2E1 HDAC8 UBE2D1 HDAC9 ANAPC10 HDAC6 ANAPC11 HDAC7 CCNB1 ZNF746 CDC23 RFFL UBE2S ZNF740 CDC26 SMARCE1 CDC16 KCNIP3 CDC27 TXNRD1 ZCCHC8 CDK1 KLF4 ANAPC4 PML ANAPC5 TP53RK ANAPC1 HDAC10 ANAPC2 HDAC11 ZNF606 ZNF605 SRC RUNX3 ZNF839 ZNF555;ZNF57;ZNF556 RBM7 ZFPM1 TWIST2 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 NUAK1 PPHLN1 CTNNB1 TP53BP2 TASOR MET BANP GADD45A TPX2 CITED1 CITED2 CITED4 INS;INS-IGF2 PRMT6 YWHAB PRMT1 GP1BA COX7A2L-1 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 MAPK1 NPY ARNT2 STEAP3 MAPK3 LMO1 ZNF197;ZNF660-ZNF197 LMO2 KCTD1 MAPK14 ATP1B4 LIFR KCTD6 FANCD2 ZNF124-4 MAPK11 NOP2 COX7A2 NPM1-2 PMAIP1 SMAD1 SMAD4 CBX5 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 TP53I3 JMY KDM5B ATF2 THRA YBX1 NR2E1 SMARCD3 CASP6 CASP2 HDAC3 CTSV;CTSL AXIN1 OPRM1 ARID1A ARID1B RBL2 RBL1 ARNTL IFNG NR2C2 THBS1 HSPD1 XPO1 ERBB2 HES1 ZNF286A EP300 ZNF189 ZNF184 ZNF180 OPRK1 PPARGC1A ARID3A DEK NCOA1 MED1 MBD2 NCOA2 MEF2C CREBBP NCOA6 NR1D1 SIRT1 HCFC1 NCOR1 TBL1XR1 CARM1 NFATC2 CALM3;CALM1 YWHAE JUN FASLG CDC25C SOD2 FOXO3 PRDX2 BCL2L11 CDK5 PRDX1 CDK5R1 NOTCH1 RBX1 CAVIN1 IHH CRH CXXC1 FIP1L1 PAXIP1 GAD1 SMARCA5 GAD2 BAZ1B ANGPTL4 LPL RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 SKP2 DAXX TFDP1 ARID4B CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 SAP30 PPP2R1B SAP30L PPP2R1A SAP18 SUDS3 CPSF2-1 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T WDR33 NUDT21 CLP1 PCF11 PAPOLA SYMPK PPP2CB;PPP2CA PPP2R5C BIRC5 AURKB MSH2 PMS2 MLH1 TJP1 OCLN-1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L RNGTT LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 H2AC14 AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A2 PRKAB1 CSNK2B MAPKAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 WWTR1 YES1 BCL7A MOV10 BCL7C AGO4 DPF1 BCL7B H2AC20 AGO2 DPF2 DPF3 SS18 H2AB2;H2AB3;H2AB1 EZH2 SS18L1 PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 TEAD4 FOS H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 RICTOR SUZ12 H2BC5 STAT1 H2BC1 MTA1 MTA3 H2AC4 KMT2A KMT2C TCF7 PRR5 GSK3B DPY30 H2BC21 WDR5 MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 PRKAA1 PRKAA2 LEF1 PLD6 AGPAT2 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYBBP1A RBBP7 TCF7L2 TDG TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B CCNK CCNT1 ELL GTF2B ELOC-1 TAF7L ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H TBP ADIPOQ NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 DNMT3L SPOCD1 TAF11 SSRP1 C19orf84 CDK9 PIWIL2 NCBP2-1 PIWIL1 CCNT2-1 PIWIL4 TAF8 TCEA1 DDX4 TAF4B HENMT1 TAF7 ASZ1 TAF6 MAEL TDRKH-1 TAF5 MOV10L1 TAF4 MYBL1 TAF3 TAF2 TDRD9 TAF1 TDRD6 TDRD1 TDRD12 FKBP6 PLIN2 TP53 RRP8 ACTB-1 UHRF1 TET3 KDM6A SSB PSIP1 NFIX NFIA NFIB NFIC PDK4 LIPE DGAT2 FABP4 CPSF4 TGFB1 PLIN1 LPIN1 MGLL HSP90AA1 PARP1 TFAM-1 TFB2M PAGR1 PABPN1-1 RAN BLK ELF1 AJUBA ELF2 CBFB PAX5 RUNX1 EZH1 PHF19 EPOP PHF1 JARID2 TET2 TET1 MTF2 IPO8 MTERF1-1 SOX2 ZNF521 TSNAX PRKRA DICER1 TARBP2 TSN TRPC3 CEBPA PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA CPSF7 FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 KAT8 PHLDA1 BOD1L2;BOD1 ACSL1 HCFC2 WDR82 PEX11A BOD1L1 MBIP TASP1 DR1 CIDEC TADA2A ZZZ3 YEATS2 TADA3 NFYB AKAP8L NFYC SGF29 ELOVL5 PHF20L1 GPAM PLIN4 SP1 KANSL1 SCD KANSL2 SRRT NFYA-1 KANSL3 THRSP PNPLA2 CASP1 TP63 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CYCS-1 OGT-1 ITCH DNMT3B DNMT3A FAS BAX STUB1 DNMT1 SF3B1 PRKACA-1 CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 ANG MDM2-2 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 AFF4 CBX4 MLLT1 CBX2 MLLT3 SUPT6H PHC3 IWS1 EAF1 EAF2 IL6 MDM4 BMI1 CCNA2-1 RING1 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B CD36 JAG1 DLL1 SUV39H1 PHAX SNRPD3 PRMT5 ATF7IP SETDB1 AEBP2 SNRPF SNRPB SNRPE-2 SNRPG-2 PHF20 CHEK2 ZNF385A PCBP4 MPHOSPH8 GRIN2A CAMK4 PLK2 MDC1 SPI1 NOC2L RBPJ TGIF1-1 ZNF287 ZNF18 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 CLDN5 SCO2 DDIT3 DDIT4 TXNIP MEAF6 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 CCNC-1 SFN ZNF268 PPARGC1B PRELID3A ZNF263 ABCA6 NR2F1 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF496 CBX3-1 ZNF250 UCMA ZNF45 MED16 MED15 BBC3 MED17 MED12 MED14 MED13 HEY1 CASP10 MED10 HEY2 ZNF41 MORC2 ZNF248 ZNF485 ZNF483 CNOT6L ACTL6B ACTL6A MED27 MED26 DDB2 SIRT3 MED23 MED25 MMP13 MED24 MED20 ZNF235 PPARD ZNF473 SERPINB13 ZNF470 HTT EGFR PLAGL1 SPP1 ZNF226 BID ZNF222 MBD3 USP9X ATAD2 CR1L;CR1 ZNF669;ZNF670 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 CENPJ SNAPC5 AGRP SNAPC1 ZNF215 SNAPC2 ZNF214 SNAPC3 ZNF213 SNAPC4 ZNF697 ZNF143 ZNF696 BRF2 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 RORC RORB YY1 SESN3 SESN2 ZNF689 ZNF205 KMT5A ZNF688 ZNF446 ZNF445 PITX2 ZNF202 ZNF200 BNIP3L ZNF160;ZNF347;ZNF665-1 GTF3C1 ZFP69B GTF3C2 FOXP3 GTF3C3 CRCP NPAS4 MAF GTF3C4 PVALB GTF3C5 ZNF432 BRF1 KMT2D POLR3GL GRIA2 GTF3A MAX GTF3C6-1 DLX5 POLR3A DLX6 POLR3B KMT2B POLR3C FOXO4 POLR3D SOCS3 POLR3E ATXN3 POLR1C MED30 POLR3F ZKSCAN8 POLR1D ZNF668 POLR3G ZNF667 POLR3H ZKSCAN5 BDP1 ZNF664 POLR3K BCL2L14 SOCS4 ZKSCAN1 ZNF420 ZNF662 ZNF660 BRPF1 FBXO32 G6PC1 RGCC ZNF419 ZNF658 ZNF416 PIN1 SP7 ZNF655 TFAP2E;TFAP2B PPP1R13B COX4I1 COX4I2 PTEN ITGAL PPP1R13L ZNF649 DGCR8 YAF2 ZNF641 NKX3-2 TRIM63 ITGA4 APAF1 TNFRSF18 ARNT ZKSCAN7;ZNF852 RABGGTB RABGGTA RRM2B ZNF264;ZNF805-1 HAND2 ITGA5 SRF PPM1D TP53INP1 ZNF624 E2F5 ZNF621 E2F6 E2F7 E2F8 ZNF747;ZNF764 PTPN1 NDUFA4 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 ZNF613 PTPN4 TRIM33 SMARCB1 UXT LGALS3 TRIM28 EPC1 CCN2 SMARCC1 SMARCC2 ZFP1 ZNF713 ZNF711 ZNF710 BCDIN3D KCTD15 L3MBTL1 XPO5 L3MBTL2 DROSHA NABP1-1 FOXG1 TGFA INTS1 ZNF707 INTS3 ZNF706 INTS2 ZNF704 INTS5 ZNF703 INTS4 HIVEP3 INTS7 APOE INTS6 PCK1 INTS9 CRADD INTS8 IQSEC3 INTS11 SMARCA2 INTS12 SMARCA4 INTS13 SNW1 INTS14 ITGBL1 INTS10 TP73 ICE1 COX7B ICE2 MSTN SSU72 HNF4G NABP2 COX7C ELL2 CTSK ELL3 HNF4A ZC3H8 COX8A RPRD2 SREBF1 RPAP2 PBRM1 RPRD1B COX8C RPRD1A FOXO1-1 POU2F2 BRPF3-1 SATB2 COX5B COX5A RXRB ZFP14 PERP RXRG COX6C GCK VEGFA TTC5 CCNG2 CCNG1 MED31-1 MAMLD1 POU2F1 ZFP28 PRDM1 COX6A1 NCOA3 COX6A2 NR5A2 ZNF274;ZNF74 NPPA ARID2 G6PD MSX2 COX6B2 GEM COX6B1 GPRIN1 ZNF354A;ZNF354B-4 SMYD2-1 NDRG1 IRAK1 SMAD2;SMAD3 ZNF324B;ZNF324 TFAP2A ZFHX3 TFAP2C TFAP2D AUTS2 CNOT10 IL2 IL3 BMP2 CNOT11 DYRK2 LDB1 CHD4 CHD3 PIDD1 YWHAQ MYBL2 RBM14 TGIF2 CAT TMEM219 RETN AURKA MTA2 ZNF804B REST KRAS ZNF175 MAML2 MAML1 SERPINE1 GLS SGK1-1 MYB NAMPT PIP4K2A PIP4K2B JUNB RNF111 GAMT PRDM7;PRDM9 MED8 MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 E2F4-1 ZNF394 NEDD4L LSM10 PSMD8 NKX2-5 SLBP NR2C2AP PSMD6 LSM11 PLK3 PSMD7 TTF1 NFE2 PSMD2 PRELID1 SAP130 PSMD3 ZNF383 UBTF PSMD1 SAP30BP ZNF382 ZNF140 POLR1A SETD1B POLR1B SETD1A POLR1E CDC7 POLR1F SKP1 NR1D2 POLR1G PRKCB ZNF699-7 POLR1H BAZ2A CDK12 TAF1D CDK13 PSMC2-1 PSMA5 TAF1B ZNF135 PSMA6 TAF1C ZNF133 PSMA3 TAF1A RET PSMA4 GPI PSMA1 BTG2 UBA52 RARG BTG1 PSMD12 SETD9 PSMD11 CHM PSMD14 ZNF568-3 PSMD13 GLI3 GLI2 CUL1 UBE2D3-1 RELA ING5 PSMA7 ING2 PIP4P1 PSMB6 AIFM2 PSMB7 RSPO3 PSMB4 TNKS1BP1 PSMB5 ZIK1 PSMB2 BRD2 PSMB3 BRD1 PSMB1 TCF12 RPS27A NCOR2 UBB;UBC KAT2B KAT2A ADRM1 NFKB1 TAL1 RARB PSMA2-1 ZNF599 SEM1 ZNF114 PSMC5 RRM2-1 PSMC6 ZNF597 PSMC3 ZNF112 PSMC4 GPS2 PSMC1 BRD7 ZIM2 ZNF584 ZNF583 WWOX TIGAR ZNF582 PCGF6 HDAC4 PCGF5 UBE2I PCGF2 WWP1 THRB VDR HIPK1 RRN3 NR1H2 POU4F1 RORA ERCC6 POU4F2 NR3C1 HIPK2 RYBP ESR1 ZNF334 NR2C1 ZNF573 ZNF331 CSF2 NR4A2 NR5A1 ZNF570 AR ITGA2B RXRA YEATS4 MCRS1 SUMO1 ZFP30 ZNF569 SUMO2 ZNF567 RARA ZNF566 PPARG ZNF565 ZFP37 PGR PPARA ZNF563 MEN1 MTREX MRE11 IGFBP1 BRCA1 USP7 ACSS3 PF4;PF4V1-1 IGFBP3 KAT5 USP2 EXO1 ZNF302;ZNF181 NRBP1 CHEK1 KAT6A NBN ZNF317 ZNF311 TOPBP1 FKBP5 ZNF793 NOTCH2 CSF1R RFC5 RMI2 ZNF792 NOTCH3 RFC3 POLRMT ZNF791 RFC4 NOTCH4 RMI1 KRBA1 ZNF549 RFC2 ZNF548 TOP3A HUS1 ABL1 ZNF304 ZNF546 ZNF786 RAD51D SKIL PLXNA4 DNA2 RHNO1 ZNF300 ESRRA BLM FANCI ZNF782 ESRRB PCNA ESRRG FANCC CNOT4 CDK8 WRN CNOT6 BRIP1 ZFP69 CNOT7 BCL6 CNOT1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 TP53 ZNF385A PCBP4 CDKN1A SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease FGFR1 NCBP2-1 FGFR2 GAB1 TRIM24 PLCG1 STAT1 STAT3 BAG4 FGFR3 CEP43 STAT5A LRRFIP1 STAT5B POLR2A POLR2B NRAS POLR2C POLR2D POLR2E POLR2F POLR2G HRAS POLR2H POLR2I POLR2L FRS2 GTF2F1 GTF2F2 PIK3CA FGF1 POLR2J;POLR2J2;POLR2J3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 SOS1 FGF20 FGF23 FGF22 GAB2 FGF16 FGF18 FGFR4 BCR FGF10 PIK3R1 CUX1 FGFR1OP2 MYO18A CPSF6 ERLIN2 NCBP1 ZMYM2 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade GP1BB FGB GP5 FGA VWF FGG F10 ANO6 F11 F5 F8 GGCX TPST2 PROC TPST1 F9 PROS1 F2 GP1BA GP9 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy EPAS1 USP30 ATM SQSTM1 PEX5 MAP1LC3B2;MAP1LC3B-1 NBR1 UBA52 RPS27A UBB;UBC SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer CLIP1 MAPK1 PIK3CB PIK3R2 MAPK3 PIK3R1 PIK3CA NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals UNC5A PTPN11 UNC5B NTN1 DCC SRC UNC5C UNC5D MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 TNIP2 USP18;USP41 OPTN-1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE UBE2D1 MAP3K8 NFKB2 IRF7 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 PTPN11 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C MAPK9 MAPK8 TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 UBE2D3-1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB TBK1 IRF3 CASP8 RIPK3 RPS6KA5 TRAF2 BIRC2 BIRC3 HMGB1-1 RIPK1 RIPK2 FADD ATF1 SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2D3;UBE2D2 UBE2N VRK3 TAB3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT5 CCT4 TUBB4B CCT6A TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 CCT6B PFDN4-1 TUBA1C TUBA1A TUBB1 CCT3 CCT2 TUBB2B;TUBB2A VBP1 TUBA4A TCP1 PFDN1 PFDN2 PFDN5 TUBB3;TUBB6 PFDN6 CCT8 TUBA3E;TUBA3C-1 CCT7 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport DLST PC UCP1 COX7A2L-1 SCO2 COX7A2 SLC25A18 SIRT3 MDH1 MDH2 SLC25A12 SLC25A22 SLC25A11 SLC25A13 SLC25A27 UCP3 UCP2 SLC25A14 OXA1L MRPS36 COX15 COX4I1 COX4I2 HIGD1A DLD COX19 CYCS-1 COX17 SLC25A4 WDR26 GLO1 GPT PDHB RMND5B LDHB LDHA MAEA CS RMND5A PDPR NDUFS3 MPC1 MPC2 ACO2 PDK4 MPC1L NDUFA4 PDK3 NEK1 ME3 DLAT ATP5MC2 ATP5MC3 ME2 PDK2 PDK1 TIMM21 PDHX ATP5MC1 NDUFB8 FAHD1 ATP5F1A PDHA1 SIRT4 ATP5F1B ARMC8 PDP1 MKLN1 LDHA;LDHC ATP5MJ GID4 ATP5MG NDUFA5 PDP2 ATP5ME DMAC2L GID8 IDH3G LDHAL6B HSPA9 ATP5PF ATP5PD LETM1 ATP5PB ATP5F1C ATP5F1D ATP5PO COX7B COX7C COX8A COX8C SMIM4 UQCC3 COX5B UQCRB COX5A UQCC2 UQCC1 UQCR11 HSCB UQCR10 BCS1L COX6C TTC19 LYRM4 UQCRQ LYRM7 UQCRC1 C12orf73 UQCRFS1 CYC1 UQCRC2 COX6A1 FXN COX6A2 COX6B2 COX6B1 ETFB NDUFAB1 ISCA2 ISCA1 CMC1 PYURF SCO1 SUCLG2 RANBP9 SUCLG1 TMEM126B NDUFC2;NDUFC2-KCTD14 PM20D1 TRAP1 SURF1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 NDUFS5-1 HCCS TMEM186 NNT RAB5IF ACAD9 COQ10B TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH DMAC2 PET117 UBA52 TIMMDC1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT COQ10A-1 SDHC SDHD SDHA GOT1-1 SDHB GOT2-1 NDUFB10 NDUFB11 COX18 COX11 RPS27A COX14 VDAC1 UBB;UBC NDUFV3 NDUFV2 NDUFV1 COA3 IDH2 TMEM126A-1 HIGD2A COX20 ETFA TMEM223 IDH3B IDH3A COA5 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS2 NDUFS1 SMIM20 NDUFB9 GSTZ1 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 ETFDH NDUFB2 NDUFB1 FOXRED1 NDUFA9 ME1 NDUFA8 NDUFA7 NDUFA6 NDUFA3 SUCLA2 ACAT1 ADHFE1 D2HGDH L2HGDH ECSIT OGDH REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components TESK1 RSU1 PARVA PARVB ARHGEF6 LIMS4;LIMS1 PXN ACTN1 TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism GSTZ1 HGD TAT FAH HPD GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling HBEGF HRAS EGFR ERBB2 NRG2 NRG3 SOS1 NRG4 EGF NRG1 EREG BTC NRAS IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) TLR10 TLR5 IRAK4 MYD88 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYS1 GYG1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 SEC11A SEC11C RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A DDOST RPL13A-1 RPL11 RPS27L RPS15A SPCS3 RPL14 SPCS2 RPS3 SPCS1 RPL13 RPL12-1 RPS2 SEC61A2 RPL18 RPL17 SEC61A1 RPL19 SEC61G RPL35A SEC61B RPL23A RPL22L1 FAU RPL26L1 RPS27 UBA52 RPS27A SRPRB-1 SSR1 SRP19 SRP14 SRPRA TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 RPN2 SRP68 RPN1 RPL4 RPL30 RPL3 RPL32 RPL31 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) DUSP6 DUSP7 MAPK7 RPS6KA1 FOS NAB1 NAB2 ARC TRIB1 TPH1 RRAD EGR3 EGR4 FOSL1 ID3 ELK1 ID2-1 LYL1 F3 VGF ASCL1 FOSB CDK5R2 CDK5 CDK5R1 ID1 SH3GL3 TCF12 DNM2 EGR1 MAPK1 MAPK3 EGR2 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK2 RPS6KA3 RPS6KA2 RPS6KA5 ATF2 CHD4 ID4 PPP2CB;PPP2CA JUND REST SRF EP300 SGK1-1 ATF1 PPP2R5D MEF2D JUNB DUSP4 MEF2C MEF2A DUSP3 VRK3 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT MYH10 RAC1 RHOC CIT MYL6 RHOB PPP1R12A DLG4 PPP1R12B KIF14 CDKN1B RHOA MYL12B PRC1 MYH11 MYH9 PPP1CB MYH14 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type CYP2D6;LOC107987479;LOC107987478-1 CYP2J2-1 CYP2C9;CYP2C19 CYP2C18-1 AHR CYP2W1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 CYP2S1 PTGIS CYP1A2 TBXAS1 CYP1A1 AHRR CYP8B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP2F1 POMC CYP2R1 CYP2U1 CYP1B1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP51A1 ARNT2 CYP27A1 CYP4V2 NR1H4 CYP7B1 CYP7A1 RXRA FDX1 FDXR CYP26A1 CYP26B1 CYP24A1 CYP21A2 CYP11B1;CYP11B2 CYP46A1 CYP39A1 POR CYP27B1 ARNT CYP4B1 CYP4F22 CYP11A1 NCOA1 NCOA2 CYP19A1 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism GLYCTK AKR1B1 SORD KHK ALDH1A1 ALDOB TKFC DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production NFKB1 RELA NFKB2 IRF7 DHX9 DHX36 MYD88 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction KCNK5 KCNK12 KCNK15 KCNK9 KCND1 KCND2 KCND3 AKAP9-1 KCNA5 KCNJ14 RYR1 KCNIP3 RYR2 KCNK2 AHCYL1 KCNK3 ATP2A3 ATP2A2 ATP2A1 KCNK4 RYR3 SLC8A1 SLC8A2 PRKACA-1 NOS1 CLIC2 ABCC9 ATP1B2 ATP1B1 TRDN ASPH STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ITPR2 MME ATP1A3 ATP1A2 ITPR3 CES1 SRI ATP1A1 TNNI3 CAMK2G KCNJ11 DMPK NPPA ATP1B3-1 ATP2B4 ATP2B3 FXYD2;FXYD6-FXYD2 ATP2B2 ATP2B1 SLC8A3 FXYD4 GATA4 FXYD3 FKBP1B FXYD1 FXYD6 SCN11A SCN9A SCN5A SCN1B SCN1A CACNG7 SCN10A SCN8A SCN4A SCN4B SCN7A SCN3B SCN3A SCN2A SCN2B NKX2-5 KCNE2 KCNE3 KCNE4 KCNE5 KCNE1;KCNE1B CALM3;CALM1 CACNA2D2 NPR1 NPR2 NPPC CORIN KAT2B CACNB1 CACNB2 TRPC1 CACNG8 HIPK1 HIPK2 KCNJ2 CACNG4 KCNJ12;KCNJ18 KCNJ4 CACNA1C CACNG6 FGF14 RANGRF FGF13 FGF12 FGF11 KCNK6 KCNK7 KCNK1 KCNIP1 KCNIP2 KCNIP4 WWTR1 KCNH2 KCNK10 KCNK13 KCNK16 KCNK18-1 KCNK17 KCNQ1 TBX5 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors FFAR4 FFAR2 FFAR1 FFAR3;GPR42 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 NTRK2 BDNF NTF4 PLCG1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events RAC1 RPS6KA1 CALM3;CALM1 KPNA2 GRIN2B RPS6KA6 GRIA1 ACTN2 GRIN2C PRKACA-1 SRC PRKAR1B PRKACB-1 GRIN1 GRIN2D GRIN2A DLG2 RASGRF2 CAMK4 RASGRF1 NEFL CAMK1 NRGN PRKAR2B CAMK2B CAMK2D CAMK2A GRIA2 NRG1 NRAS CAMKK1 CAMKK2 MAPK1 HRAS CAMK2G MAPK3 DLG1 DLG3 PDPK1 DLG4 PRKAR2A PRKAA1 PRKX PRKAA2 ADCY1 ADCY8 PRKAR1A RPS6KA3 RPS6KA2 GIT1 PRKAB2 PRKAB1 PRKAG1 PRKAG2 PRKAG3 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants CDC37 HSP90AA1 ERBIN ERBB2 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins TSG101 MVB12B MVB12A VPS37C VPS37D VPS37A RPS27A UBB;UBC VPS37B UBAP1 NMT2 VPS28 UBA52 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors NTRK2 NTRK1 ADCYAP1 NGF ADCYAP1R1 ADORA2A NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development LFNG HNF1B LHX1 WNT9B JAG1 WNT4 IRX1 DLL1 IRX2 WT1 HNF4A POU3F3 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 YBX1 PSENEN PSEN2 PSEN1 APH1A NOTCH3 NCSTN APH1B ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK TSC2 TSC1 PPM1A RRAGA RRAGC MLST8 RRAGB RRAGD CAB39 SLC38A9 RHEB PRKAA1 LAMTOR2 PRKAA2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKAB2 PRKAB1 MTOR PRKAG1 PRKAG2 CAB39L RPTOR STK11 STRADA PRKAG3 STRADB NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway MAMLD1 NCOR1 TBL1XR1 HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 NOTCH2 SNW1 HDAC3 NOTCH3 HDAC10 NOTCH4 HDAC11 NCOR2 KAT2B KAT2A NOTCH1 MAML2 MAML1 CREBBP HDAC4 RBPJ RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation POLR2E POU2F1 POLR3E POLR2F POLR1C POLR3F POLR2H POLR1D POLR3G POLR2L POLR3H BDP1 POLR3K SSB NFIX SNAPC5 NFIA SNAPC1 NFIB SNAPC2 NFIC SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 GTF3C2 GTF3C3 CRCP TBP GTF3C4 GTF3C5 BRF1 POLR3GL GTF3A GTF3C6-1 POLR3A POLR3B POLR3C POLR3D TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules SLC39A2 SLC39A1 SLC39A3 SLC27A6 SLC4A10 SLC26A7 LCN1 SLC26A9 SLC26A6 SLC25A1 MB SLC13A1 SLC13A2 SLC13A3 SLC13A4 NGB SLCO1C1 SLC5A12 SLC5A10 PIP-1 LRRC8C LRRC8D LRRC8A LRRC8B SLC13A5 LRRC8E GLTP AHCYL2 SLC35B4 AQP6 AQP4 AQP5 AQP2 AQP3 NIPAL4 NIPAL1 NIPAL2 NIPAL3 SLC11A1 AZGP1 MIP SLC22A6 SLC45A3 ANKH LCN15 LCN12 RAB11FIP2 MYO5B SLC5A5 MFSD4B-2 MRS2 SLC22A11 SLC66A1 SLC20A1 SLC31A1 ESYT3 ESYT2 SLC30A3 SLC30A2 MMGT1 ABCC4 SLC30A1 SLC41A2 ABCC5 SLC41A1 AQP10 SLC2A6 SLC2A7 CPTP ADD2 CLN3 STEAP3 SLC50A1 SLC4A8 SLC4A9 AQP11 SLC6A7 SLC6A9 SLC28A2 SLC29A1 SLC17A6 SLC28A3 SLC29A2 SLC46A1 SLC2A8 HBD;HBB HMOX1 ADD3 FURIN APOB PCSK6 PCSK5 SLC25A18 PHB APOA1 SLC25A22 SLC25A11 HBA2;HBA1 SLC2A9 RAF1 CALM3;CALM1 SLC34A2 STEAP4 TFRC SLC34A1 HFE SLC40A1 TCIRG1 HEPH SLC22A17 FTH1 ATP6V1E1 ATP6V1E2 SLC44A5 SLC5A7 ATP6V1G1 SLC10A6 ATP6V0B ATP6V1G2 SLC44A3 SAR1B SLC44A4 GLRX3 SLC44A1 ATP6AP1 SLC11A2 SLC44A2 STOM TFR2 ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ADD1 ABCG2 ATP6V1B1 ATP6V1A MBTPS1 IREB2 CAND1 FTMT ATP6V0A2 GNGT1 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D HMOX2 ATP6V1C1 ATP6V1C2 ATP6V0A1 ATP6V1F FTL-1 MBTPS2 CYBRD1 CP TF GNAS-1 ATP6V0E2;ATP6V0E1 LCN2 ACO1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 ABCA12 SLC9A1 SLC4A4 BSG GNG10 ABCD1 SLC39A4 SLCO2A1 SLC27A4 GNG2 ABCB6 GNG5 ABCB4 GNG4 SLC5A2 GNG8 SLC33A1 PEX19 SLC6A5 SLC26A4 SLC26A3 SLC6A2 SLC22A12 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC2A10 ABCC6 SLC29A3 SLC24A4 SLC20A2 SLC35A2 SLC16A1 SLC24A5 SLC22A5 GNG13 GNB2 RSC1A1 VLDLR SLC5A1-1 GNB1 SLC2A2 GNB4 SLC6A3 GNB3 GNB5 SLC22A18 HDLBP PCSK9 AP2A1 AP2A2 LIPA LIPC NPC1-1 CREB3L3 LIPG SLC24A2 LDLRAP1 SLC24A3 AP2M1 MYLIP CUBN AMN APOA2 APOA4 LSR APOA5 SOAT1 SOAT2 NPC2 ANGPTL8 ANGPTL3 RYR1 ANGPTL4 RYR2 CES3 ABCG1 ATP2A3 CETP ATP2A2 MTTP ATP2A1 RYR3 LCAT SLC8A1 LPL SLC8A2 LMF2 ADCY9 LMF1 PRKACA-1 PRKAR1B PRKACB-1 AP2S1 CLIC2 APOF ABCC9 A2M ATP1B2 LDLR ATP1B1 FGF21 TRDN GPIHBP1 ASPH ABCA1 PRKAR2B APOC4 APOC3 APOBR CAMK2B NR1H3 CAMK2D AP2B1 CAMK2A NCEH1 ATP1A4 APOC2 ALB APOC1 ATP1A3 P4HB ATP1A2 SRI SLC35B3 SLC35B2 ATP1A1 CAMK2G KCNJ11 ATP1B3-1 ATP2B4 ATP2B3 FXYD2;FXYD6-FXYD2 ATP2B2 ADCY4 ATP2B1 SLC8A3 FXYD4 FXYD3 ADCY3 FKBP1B FXYD1 ADCY2 FXYD6 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SLC35D2 SLC22A3 ABCB1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 SLC12A6 SLC12A7 SLC17A5 STOML2 MCUB SLC4A7 SPG7 PHB2 SLC8B1 MAIP1 PARL SLC26A11 AKAP1 AFG3L2 VDAC2-1 AVPR2 SMDT1 VDAC3 AVP YME1L1 PMPCB VDAC1 MICU3 PMPCA MICU2 MICU1 SLC26A2 MCU SLC26A1 AQP8 SLC25A10 ABCC3 SLC2A1 EIF2S2 EIF2S3;EIF2S3B EIF2S1 ABCC1 SLC35A3 SLC43A2 SLC1A1 SLC43A1 SLC2A4 SLC1A2 ERLIN1 SLC3A1 ERLIN2 SLC24A1 SLC1A3 SLC3A2 SLC1A4 SLC7A11 SLC1A5 SLC16A7 SLC7A10 SLC16A8 SLC1A6 EMB SLC6A20 SLC7A1 SLC16A3 SLC1A7 SLC7A3 SLC25A29 SLC38A3 ATP8A2 SLC38A2 MAGT1 ATP8A1 SLC36A4 ATP12A SLC38A5 BEST2 SLC38A4 BEST3 SLC36A1 SLC9C2 SLC38A1 BEST1 SLC6A19 BEST4 SLC36A2 ATP11C SLC6A15 ATP11B SLC6A14 ATP11A SLC6A12 SLC16A10 SLC9B1 SLC7A5 SLC9B2 SLC6A6 SCNN1G SLC7A6 CLCA4-1 SLC7A7 SCNN1D SLC7A8 SCNN1B SLC7A9 SCNN1A TTYH3 TTYH2 WNK4 DERL3 DERL1 NALCN DERL2 ASIC4 ZDHHC8 ASIC5 CLCA2 OS9 CLCA1 ASIC2 ASIC3 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B ATP4A WNK1 WNK3 VCP-1 CUTC UNC80 TUSC3 ABCD2 CLCNKA;CLCNKB ATP7B ABCD3 ABCC10 ATP7A CLCN6 TSC22D3 PEX3 ANO8 ABCG4 ABCB5 ANO9 ABCB8 ANO6 ABCB9 ANO4 ANO5 ABCF1 ABCA2 ANO2 ABCA5 ANO3 ABCA4 ANO1 ABCA9 STOML3 ABCA7 ATP10D SEL1L ABCA8 ATP10B ABCB10 ATP10A ATP2C2 ATP2C1 CLCN3 CLCN2 CLCN1 BSND ANO10 ABCG8 SGK3;C8orf44-SGK3 ABCG5 ATP9B RNF185 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN5 CLCN4 OSTM1 ATP13A4 ATP13A5 ATP13A2 UNC79 RNF5 PRKAR1A ERLEC1 RHCG RHBG ABCA6 SLC5A8 CFTR RAB11A ARL2 APOD AQP9 LOC100509620;LOC112267859;AQP7 FBXL5 CYB5R2 CYB5R1 CYB5R4 CA1 CA2 CA4 RHAG SLC4A1 CYB5RL SLC25A5 SLC25A4 AQP1 SLCO1A2 SLC25A6 SLC22A8 LETM1 ESYT1 APOE SLC22A4 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC30A8 SLC30A5 CLTC CLTA ABCA3 PRKAR2A RUNX1 SLC17A8 SLC5A6 PDZD11 SGK1-1 SLC15A1 SLC35C1 CTNS SLC15A3 SLC15A4 NEDD4L PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SLC35A1 PLEKHA8 SKP1 PSMC2-1 PSMA5 PSMA6 SLC6A13 PSMA3 PSMA4 PSMA1 SLC6A11 UBA52 SLC22A2 SLC22A1 PSMD12 SLC6A1 PSMD11 SLC6A4 PSMD14 PSMD13 CUL1 SLC32A1 PSMA7 PSMB6 ARF1 PSMB7 SLC17A7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 TRPM1 TRPM2 PSMA2-1 TRPM7 SEM1 TRPM8 PSMC5 TRPM5 PSMC6 TRPM6 PSMC3 TRPM3 PSMC4 TRPM4 PSMC1 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 WWP1 TRPV1 MCOLN1 NR1H2 TRPC4AP MCOLN2 ABCB7 TRPV6 TRPV4 TRPV5 SLC2A13 SLC5A11 SLC5A3 ABCC2 SLC35D1 SLC4A2 SLC4A3 SLC4A5 SLC5A9 SLC30A10 SLC5A4 ARL2BP SLC2A11 SLC2A12 NIPA1 SLC39A10 NIPA2 SLC39A14 SLCO4A1 SLC29A4 DMTN SLCO4C1 SLC28A1 SLC27A1 SLCO2B1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 CYGB SLC16A2 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases RHOU YWHAH LBR PTK2B PRKCD YWHAZ WDR91 ANKFY1 PLK1 WDR81 SH3RF1 CDC42SE2 ARHGAP9 OSBPL11 LRRC1 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 KCTD3-1 FGD5 CHN2 CHN1 FARP1 DEF6 WDR11 SRC CAV1 SHKBP1 FILIP1 STAM GOPC UHRF1BP1L CDH1 FAM13B HGS FAM13A CTNNB1 RALGAPA1 STAM2 TEX2 FAM91A1 ARMCX3 DDRGK1 NSFL1C ZNF512B VAV3 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 YWHAB PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 SH3BP1 MAPK1 WHAMM VAV2 GOLGA3 BAIAP2L2 STEAP3 MAPK3 SPATA13 KIDINS220 TMEM87A FAF2 FRS2 AKAP12 HINT2 MAPK14 ITSN2 SH3PXD2A CCDC115 RALBP1-1 RHOH HSP90AB1 RHOF MAPK11 ROCK1 RHOD ROCK2 RHOV GPS1 ACBD5-1 TWF1 EMC3 RAPGEF1 MSI2 PRAG1 RHOBTB1 SOS1 ARHGAP44 RHOBTB2 SYDE2 ACTG1 DOCK11 BASP1 TRA2B STK38 ARHGAP45 MYO6 ARHGAP19 RBBP6 ARHGAP18 TOR1AIP1 SPEN RNF20 ARHGAP12 SCFD1 ARHGAP22 CPSF7 ACTN1 ARHGAP20 TMOD3 ARHGAP29 TXNL1 MACO1 COPS4 ARHGAP28 CDC37 ARHGAP27 PICALM CFL1 COPS2 ARHGAP25 ARHGAP24 PDE5A PHIP ARHGAP23 HNRNPC ARHGAP33 ARHGAP31 VIM DIAPH2 RBMX DBN1 DNMBP ARHGAP30 DOCK6 CTTN DOCK9 RND2 PGRMC2 ARAP1 XPO1 ALS2 PEAK1 CCDC187 MOSPD2 ARHGAP11A-1 ADD3 FAM169A FMNL1 FMNL2 TRIP10 NCOA2 IQGAP1 GRB7 KIF14 STMN2 MAP3K11 RND1 STIP1 KDM4C-1 KLK3;KLK2 LAMTOR1 WDR6 PLXNA1 CALM3;CALM1 FAM83B ANKRD26;CCDC144A;LOC105375816 DST YWHAE RRAS2 ALDH3A2 TMEM59 CCDC88A FAM135A CDC25C ACTC1;ACTG2 VANGL2 RTKN UBXN11 SOWAHC CPD ARHGEF10L AKAP13 DLG5 LMNB1 STK10 PKP4 SLK ARHGEF11 TFRC ARHGEF10 ARHGEF12 STARD8 ARHGEF17 CIT RHOB DAAM1 ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 PKN3 ARHGEF28 IQGAP3 ATP6AP1 STOM RHPN2 ECT2 STARD13 JUP CAVIN1 PCDH7 MYO9A NET1 ANLN DIAPH1 DLC1 PKN2 PKN1 HMOX2 ARHGEF40 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 RHOC TIAM2 ARHGEF4 ARHGEF7 DLG4 NGEF ARHGEF6 FGD1 NCKAP1 FGD2 WASF1-1 FGD3 NCF1 GNA13 FGD4 NCF2 SNAP23 NCF4 ARHGAP6 FLOT1 DOCK10 SYDE1 ARHGEF39 FLOT2 ARHGAP42 PLXNB1 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 ARAP3 CYBB OCRL CYBA BCR AMIGO2 NOXO1 DBT BCAP31 ARHGAP17 ARHGAP15 ABR RACGAP1 SLITRK3 NHS SLITRK5 NCKAP1L WASF2 GIT2 BAIAP2 ARHGAP26 ABI2 TAOK3 ABI1 NOXA1 NOX3 NOX1 FERMT2 C1QBP SAMM50 CUL3 RASAL2 MTX1 LIMK2 LIMK1 MYH14 CYFIP2 MYH10 WIPF1 WIPF2 WIPF3 CTNNA1 CDKN1B BTK PLXND1 NCKIPSD DVL1 DVL2 DVL3 ARPC4 ARPC5 ARPC2 ARPC3 ERCC6L ACTR3-1 NUP107 ARPC1B ARPC1A ZWILCH WASL BUB1B PMF1;PMF1-BGLAP ACTR2 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 WAS SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 WASF3 NUP160 SKA1 SKA2 DSN1 PREX2 NUP85 RCC2 NDC80 WWP2 ZWINT KIF18A ARHGAP10 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D DOCK7 PPP2R5C RANGAP1 CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B MRTFA ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 SENP1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 DOCK3 CENPE CENPF CENPH FRS3 CENPI TAOK1 CENPK TIAM1 CENPL CPNE8 CENPM PTPN13 DOCK8 FNBP1L B9D2 FNBP1 CENPO SCRIB CENPP CENPQ NIPSNAP2 RHOJ SPC24 CDC42BPB SPC25 CDC42BPA MAD2L1 SLC4A7 NUP37 FMNL3 JAG1 LIN7B DSP RASGRF2 DSG1 DSG2 TJP2 H2AC14 PIK3R3 PIK3R2 PIK3R1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 SLC1A5 H2AB2;H2AB3;H2AB1 RAC1 PPP1R14A PPP1R12A FARP2 PPP1R12B VAV1 H2AJ ARHGAP39 SRGAP3 SRGAP2 SRGAP1 PAK1 PAK3 PAK2 H2BC5 H2BC1 VCP-1 PARD6B ABCD3 H2AC4 CCP110 CEP97 MYH9 H2BC21 YWHAG PRKCA PDPK1 H2AZ2;H2AZ1 PIK3CA LCK CDC42 SFN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PLD2 CSK H2BC15;H2BC3;H2BC11;H2BC12 DDX4 USP9X GJA1 UACA CFTR CCT2 CCT7 S100A9 S100A8 CCT6A ACTB-1 ARHGEF18 PRKCZ RHOA PARD6A PIN1 AAAS ARL13B ITGB1 CYFIP1 DOCK5 DOCK4 ANKLE2 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L STBD1 ARHGDIB EMD TMPO PLEKHG3 SRF ARHGEF16 RHOG VRK2 KLC1 LEMD3 KLC4 KLC3 ARFGAP3 DEPDC1B KLC2 NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 EPHA2 VAMP3 RAB7A GARRE1 ARHGEF26 SHMT2 PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 STX5 YKT6 PAK4 NDUFA5 MCAM MCF2 ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 PPP1CB FLNA MYL12B MYLK KIF5B MYH11 KIF5A KDM1A TPM4 CLTC TPM3 PTK2 BUB1B-PAK6;PAK6 MYL6 HSP90AA1 PFN1 ABL2 NCK2 NCK1 SPTAN1 CAPZB MUC13 EVL PFN2-1 SOS2 YWHAQ PAK5 MYO9B MTMR1 SPTBN1 SCAI SRRM1 DDX39B TAX1BP3 NF2 ROPN1;ROPN1B PRC1 PRKCB MTR-1 PIK3R4 AR MEN1 PIK3C3 TNFAIP1 RND3 CKB SEMA4F CKAP4 NISCH KCTD13 ABL1 ZAP70 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling NTRK3 NTF3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis SCD FASN NRIP1 ANGPTL3 NR1H2 RXRB NR1H3 RXRA SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway FGB FGA FGG TLR4 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG CHUK PSMC2-1 PSMA5 PSMA6 PSMA3 CD14 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 S100A1 CD36 PSMA7 TIRAP PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A BTK UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 VAMP8 PSMC3 PSMC4 PSMC1 S100A9 S100A8 TLR1 TLR6 TLR2 SNAP23 SEC61A2 SEC22B SEC61A1 PDIA3 SEC61G SEC61B TAP2 TAP1 TAPBP STX4 B2M HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E LY96 PSME1 PSME2 HMGB1-1 PSMB10 MYD88 PSMB8 PSMB9 CALR-1 VAMP3 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) HRAS PIK3R1 PTPRO IRS1 PIK3CA SRC NELFB NTRK3 SOS1 PTPRS NTF3 BAX PLCG1 NRAS VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins GNB1 GNB4 GNB3 GNB5 GNAS-1 ADCY4 PRKAR2A ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR1A ADCY5 GNG10 AQP4 GNG2 AQP2 GNG5 AQP3 GNG4 GNG8 RAB11A AVPR2 AQP1 AVP PRKACA-1 ADCY9 PRKACB-1 PRKAR1B RAB11FIP2 MYO5B PRKAR2B GNGT1 GNG13 GNB2 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes ATF4 NFYA-1 HSP90B1 ATF6 NFYB DDIT3 NFYC CALR-1 HSPA5 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints RBBP8 ATRIP BARD1 RPA1 BRCC3 RPA2 CLSPN TP53BP1 BABAM1 YWHAH RAD50 BABAM2 UIMC1 RPA3 ABRAXAS1 RNF8 RAD17 RNF168-1 ATM NSD2 RAD1 RAD9B RAD9A ATR YWHAZ PKMYT1 H2BC5 CCNB1 H2BC1 CDK1 MDC1 YWHAB CDK2 H2BC21 YWHAG UBE2V2 SFN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCNB2 YWHAQ H2BC15;H2BC3;H2BC11;H2BC12 CDC45 MCM7 MCM3 MCM4 MCM5 MCM6 MCM2 CCNA2-1 CCNA1 GTSE1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CDC7 YWHAE PSMC2-1 PSMA5 PSMA6 PSMA3 CDC25C PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 TP53 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PIAS4 CDC6 MRE11 BRCA1 KAT5 EXO1 CHEK1 NBN TOPBP1 CHEK2 RFC5 RMI2 RFC3 RFC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RMI1 RFC2 MCM10 TOP3A HUS1 WEE1 ORC5 ORC4 DBF4 ORC6 ORC1 DNA2 MCM8 RHNO1 ORC3 ORC2 BLM HERC2 WRN BRIP1 UBE2N MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy TOMM40 MAP1LC3B2;MAP1LC3B-1 TOMM70 ULK1 TBK1 CSNK2A1;CSNK2A3 TOMM7 OPTN-1 CSNK2A2 UBA52 CSNK2B MAP1LC3A MTERF3 FUNDC1 ATG9A TOMM20 UBE2D3-1 ATG12-1 SQSTM1 TOMM22 ATG5 PRKN VDAC2-1 VDAC3 RPS27A UBB;UBC VDAC1 MFN1 MFN2 UBE2V1 UBE2D3;UBE2D2 PINK1 UBE2N FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling TAB2 TAB1 RAC1 FOS VAV1 MAP3K1 PAK1 PAK2 TEC UBE2D1 AHCYL1 GRAP2 FCER1G BTK PLCG2 VAV3 ITPR1 ITPR2 NRAS ITPR3 PIK3CB MAPK1 VAV2 HRAS MAPK3 SYK PDPK1 FCER1A MS4A2 PIK3CA SOS1 MAP2K4 FYN MAP2K7 MAPK9 MAPK8 PSMD8 IKBKB PSMD6 PPP3CA PSMD7 PPP3CB PSMD2 PSMD3 RASGRP1 PSMD1 PPP3R1 IKBKG MAPK10 BTRC NFATC3 MAP3K7 NFATC2 SKP1 NFATC1 CHUK CALM3;CALM1 FBXW11 PSMC2-1 PSMA5 JUN PSMA6 PSMA3 PLCG1 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 TXK PSMC3 PSMC4 PSMC1 GAB2 PIK3R2 PIK3R1 LYN CDC34 ITK TRAF6 PRKCQ UBE2V1 RASGRP2 LCP2 RASGRP4 UBE2D3;UBE2D2 UBE2N LAT2 TAB3 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint CDK1 CCNA2-1 PKMYT1 WEE1 CCNA1 CCNB2 CCNB1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 CD14 MAP3K8 BTK NFKB2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 PPP2R1B MAPK14 PPP2R1A TLR6 TLR2 MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 SOCS1 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C FGB FGA MAPK9 MAPK8 FGG TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 SIGIRR CUL1 S100A1 CD36 RELA IRAK3 TIRAP RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB S100A9 S100A8 CASP8 RPS6KA5 TRAF2 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CDKN2A ATM PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MDM2-2 PHF20 PSMA7 CHEK2 PSMB6 COP1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 TP53 PSMC5 PSMC6 MDM4 PSMC3 PSMC4 PSMC1 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins RBP1 RETSAT AKR1B15;AKR1B10 VKORC1 PLB1 TTPA GPC1 CLPS HSPG2 GPC3 PNLIP APOM RDH11 GPC2 APOA2 SDC4 GPC5 APOA4 SDC2 APOE GPC4 VKORC1L1 SDC3 GPC6 AGRN TTR LRP1 LPL LRP8 SDC1 UBIAD1 LRP2 LDLR GPIHBP1 BCO2 LRAT APOB BCO1 APOC3 LRP10 APOC2 LRP12 APOA1 RBP4 RBP2 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 HRAS HSP90AA1 EGFR MATK PRKCA PTPN12 USP8 PRKCE GRB7 PIK3CA RNF41 ERBIN CUL5 RHOA GAB1 SOS1 AKT2 PTPN18 SHC1-1 AKT3 PRKCD AKT1 PLCG1 FYN EGF UBA52 EREG BTC HBEGF CDC37 PIK3R1 PTK6 SRC RPS27A YES1 UBB;UBC ERBB2 MEMO1 NRG2 NRG3 NRG4 DIAPH1 STUB1 NRG1 NRAS MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 PHF5A PPP1CB SNRPN HNRNPU CHERP PPP1CA PAPOLG CPSF4 PTBP1 SNRPA1 DNAJC8 PUF60 SNRPB2 DHX9 SRRM2 DDX5 HNRNPH1 HNRNPH2 TCERG1 SNRPC SNRPA PPP1R8;STX12 HTATSF1 RBM25 PPP1R10 CPSF2-1 CPSF1 SNRNP70 CSTF3 PRPF40A CPSF3 TUT1 CSTF2 SRSF10 CSTF2T SRSF12 WDR33 TRA2B RBM39 NUDT21 PABPN1-1 CLP1 PCF11 RBBP6 PAPOLA SYMPK CPSF7 RBM5 YBX1 HNRNPC RBMX NCBP1 U2AF1L5;U2AF1 CDC40 NCBP2-1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 UBA52 SRSF11 SRSF4-1 XRN2 RPS27A UBB;UBC SNRPD2 SNRPD1 SNRPD3 SNRPF POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 POLR2F SRRT POLR2G POLR2H POLR2I POLR2L GTF2F1 FUS GTF2F2 POLR2J;POLR2J2;POLR2J3 HNRNPA3 CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 FIP1L1 HNRNPA2B1 DDX46 DDX42 RBM17 SMNDC1 U2SURP HNRNPR MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA SIN3A HDAC1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense CASP1 GBP2;GBP3;GBP1 PIM1 SFN INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation EEF1A1 VCP-1 KIN EEF2 METTL22 FAM86B1;EEF2KMT;FAM86B2 METTL21A ETFBKMT EEF1AKMT2 EEF1AKMT1 ETFB HSPA8 CALM3;CALM1 VCPKMT RPS2 PRMT3 CAMKMT ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY4 GNAL ADCY9 ADCY3 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis AGPS DHRS7B GNPAT MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors RBFOX1 PPARG MEF2C PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling AKT2 PDE3B THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome NLRP1 BCL2 BCL2L1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 CDK2 CDC6 CDT1 MCM7 ORC5 ORC4 ORC6 MCM3 ORC1 MCM8 MCM4 MCM5 ORC3 MCM6 ORC2 MCM2 CCNA2-1 CCNA1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance AKAP9-1 PLK1 ACSS2 HDAC6 CDK1 DYNC2I2 NEK2 DYNC2I1 TRAF3IP1 IFT172 CCP110 ARF4-1 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CAMK4 CEP135 CSNK1D IFT80 CYS1 RPGRIP1L LZTFL1 IFT88 IFT81 TTC30A;TTC30B UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B NRF1 NPHP1 YWHAG CEP70 NPHP3 CEP72 MAPK14 CEP192 KIF3C MARK4 MAPK12 RAB11FIP3 CEP76 MAPK11 CEP78 BBS2 PRKAA2 PLK4 BBS1 ODF2 RAB3IP IFT122 BBIP1 PPARGC1B IFT20 AHI1 IFT22 MKS1 GABPA CEP83 SIRT5 PPRC1 IFT27 GLUD1;GLUD2 DYNLRB2 DYNLRB1 PERM1 ATF2 CEP89 CEP57 TFB1M CRTC2 TTC26 C2CD3 SMARCD3 CETN2 CRTC3 CEP164 HDAC3 CHD9 PKD2 CRTC1 PKD1 HSPB11 IFT52 ACTR1A TCTN3 TCTN2 HELZ2 CNTRL TCTN1 BBS9 CNGA2 BBS7 TGS1 CNGA4 IFT57 TNPO1 BBS5 CC2D2A PPARGC1A CEP290 BBS4 MEF2D RAB8A NCOA1 MED1 DYNLT5 NCOA2 IQCB1 MEF2C SIRT3 MKKS CREBBP EXOC8 NCOA6 DYNLT2 IFT140 NR1D1 EXOC7 HAUS4 HCFC1 KIF24 NCOR1 HAUS3 TBL1XR1 HAUS6 HAUS5 CARM1 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 BBS12 RP2 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 CALM3;CALM1 EXOC5 YWHAE IFT46 EXOC2 EXOC1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 DYNLT2B SOD2 ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT CCT3 OFD1-1 CCT2 SEPTIN2 CEP152 GBF1 WDR19 SCLT1 RAB11A ATAT1 NEDD1 TTC8 ALMS1 TUBA4A CEP162 TCP1 TRIP11 B9D1 CEP41 CLUAP1 CEP43 CCT8 CCT5 CCT4 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 SMO TPTEP2-CSNK1E;CSNK1E ALAS1 ARL13B INPP5E PDE6D CYCS-1 ATP5MC2 ATP5MC3 MICOS13 MICOS10 ATP5MC1 APOO ATP5F1A SIRT4 ATP5F1B CHCHD3 SAMM50 CHCHD6 ATP5MJ ATP5MG ATP5ME DMAC2L HSPA9 ATP5PF ATP5PD APOOL MTX1 ATP5PB MTX2 DNAJC11 IMMT ATP5F1C ATP5F1D TMEM11 ATP5PO PRKACA-1 PRKAR2B HSP90AA1 PPP2R1A TFAM-1 TFB2M MAPRE1-1 MTERF1-1 CKAP5 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 B9D2 IDH2 KIF17 RXRA PPARA PRKAB2 PRKAB1 POLRMT POLG2 TWNK RHO SSBP1 ESRRA CNGB1 PRKAG1 PRKAG2 PRKAG3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization CLDN11 RAC1 CLDN10 CLDN15 CLDN14 JAK1 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 FARP2 WT1 MPHOSPH8 H2AJ PVR CDH9 HACE1 CSNK2A1;CSNK2A3 CDH7 AGO3;AGO1 FOXQ1 PRKCSH CDH6 CDH5 CDH3 TLE1 ZBTB33 SOX10 IL6ST SDK1 HDAC2 GANAB SDK2 CLDN22;CLDN24-1 PKM SUZ12 CDH10 H2BC5 CDH12 CDH13 STAT3 CDH17 CDH18 HDAC1 H2BC1 CDH19 CTSS PARD6G PARD6B MOGS MCRIP1 CTSB NECTIN4 NECTIN3 KLF4 NECTIN2 NECTIN1 H2AC4 MYCN SNAI2 TMEM258 SRC CTNND1 TWIST2 CDH1 CTNNB1 BANP OST4 EPS15 CBLL1 RNF19B OSTC STT3A MAPK1 VAV2 H2BC21 MAPK3 EED CLDN5 H2AZ2;H2AZ1 DDOST DAD1 CDC42 RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 ACTN1 TNRC6A-1 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 ARID1A TNRC6B FURIN PCSK6 CDH2 PXN ZEB1 TRAF7 JAK2 SIRT1 VCL DST KMT5A JUP PLEC SP1 PATJ MPP5 CRB3 ARHGEF4 CTBP2 ARHGEF6 CTBP1 F11R PARD6A PARD3 ITGB1 COL17A1 BIRC2 XIAP FERMT2 CD151 DOCK1 HEYL ELMO1 ARHGAP32 FLNA SMARCA4 ANGPTL4 TESK1 PRDM8 BHLHE22 RSU1 CDH8 PARVA CTNNA1 PARVB CDH24 RB1 HOXC8 LIMS4;LIMS1 FOXF1 FLNC ADAM33 LIMS2 ADAM19 ILF3 CDH11 SNAI1 FBLIM1 ILK SEC11A SEC11C KDM1A TYK2 CANX POMT2 SPCS3 VASP SPCS2 ZNF217 SPCS1 POMT1 TFAP2A MDM2-2 ANG ANK3 TGIF2 IL6 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 TIAM1 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ZEB2 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 PSMC5 PSMC6 DNM2 PSMC3 PSMC4 PSMC1 LAMB3 LAMA3 LAMC2 H2AC14 MYC CLDN1 CSNK2A2 CSNK2B RPN2 CDH4 ITGB4 RPN1 ITGA6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDH15 FOXA2 PRKCI IL6R CLDN2 MTBP MOV10 ZC3H12A AGO4 CLDN6 H2AC20 CLDN4 AGO2 CLDN3 CLDN9 H2AB2;H2AB3;H2AB1 CLDN8 EZH2 CLDN7 CADM3 CADM1 CADM2 CLDN23-1 PCSK7 CLDN20 ZMYM2 RACK1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism UBE2I SUMO2 LGMN CYP27B1 VDR LDLRAP1 CUBN CYP24A1 PIAS4 LRP2 CYP2R1 GC NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs NEIL3 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions PTPN11 SKAP2-2 SIRPA;SIRPB1;SIRPG PTPN6 SIRPB1 TYROBP PTK2B FYB1 CD47 PTK2 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations POMT1 B3GALNT2-2 POMK DAG1 POMGNT2 POMT2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B EIF4G1 TUT7 TUT4 DIS3 DDX6 PARN LSM1 EXOSC7 LSM5 HBS1L EXOSC6 LSM4 TTC37 PATL1 EXOSC5 TNKS1BP1 NT5C3B EXOSC4 LSM3 EXOSC9 DCPS LSM2 EDC3 EDC4 EXOSC8 EXOSC3 LSM7 EXOSC2 PAIP1 LSM6 XRN1 EXOSC1 PAN2 DCP2-1 PAN3 DCP1A DCP1B WDR61 PABPC1;PABPC3 SKIV2L CNOT10 CNOT11 EIF4A2 EIF4A1 CNOT6L CNOT4 CNOT6 EIF4A3 CNOT7 CNOT1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors GNB1 GNB4 GLP2R GNB3 GNB5 VIP GNAS-1 GIP ADCYAP1 ADCYAP1R1 GIPR GHRHR GNG10 GNG2 GNG5 GNG4 GNG8 GLP1R GCGR VIPR1 VIPR2 SCT SCTR GCG GNGT1 GNG13 GNB2 GHRH DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage APRT DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 GFPT1 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID NFKB1 CHUK NFKBIA RELA NFKB2 IKBKB IKBKG IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 DNA2 SEM1 RHNO1 BLM WRN BRIP1 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR EIF2AK2 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription SIRT1 MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 CTBP2 WT1 CTBP1 MPHOSPH8 H2AJ ZNF217 FOXQ1 TLE1 H2AC14 ZBTB33 HDAC2 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PKM SUZ12 H2BC5 RBBP7 HDAC1 H2BC1 MCRIP1 SMARCA4 ZEB2 H2BC15;H2BC3;H2BC11;H2BC12 TGIF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 KMT5A SNAI2 TCF12 TWIST2 SNAI1 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 KDM1A ZMYM2 ZEB1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors PFKFB1 PPP2R5D PPP2R1B PPP2R1A PPP2CB;PPP2CA RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib CDC37 HSP90AA1 ERBIN ERBB2 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression TTF1 H2AJ MBD3 POLR1A POLR1B DDX21 POLR1E POLR1F POLR1G POLR1H GATAD2B TAF1D GATAD2A HDAC2 TAF1B SMARCA5 TAF1C SF3B1 TAF1A H2BC5 BAZ1B HDAC1 H2BC1 MTA1 MTA3 H2AC4 KAT2B KAT2A GSK3B POLR2E POLR1C POLR2F H2BC21 POLR1D POLR2H POLR2L ERCC6 H2AZ2;H2AZ1 ACTB-1 EHMT2 H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYBBP1A RBBP7 CHD4 CHD3 CBX3-1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA2 EP300 H2AC20 TBP H2AB2;H2AB3;H2AB1 DEK DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing NTHL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 HRAS PTK6 ARHGAP35 RASA1 ELMO1 RHOA CRK ELMO2 PXN DOCK1 BCAR1 NRAS P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors P2RY4 P2RY2 GPR17 P2RY1 P2RY10 P2RY11 LPAR6 P2RY12 P2RY13 LPAR4 P2RY14 P2RY6 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis AKR1B1 SORD SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport SLC39A2 SLC36A1 SLC39A1 SLC38A1 SLC6A19 SLC39A3 SLC27A6 SLC36A2 SLC6A15 SLC4A10 SLC6A14 SLC26A7 SLC6A12 LCN1 SLC16A10 SLC26A9 SLC7A5 SLC26A6 SLC6A6 SLC25A1 SLC7A6 SLC7A7 SLC13A1 SLC7A8 SLC13A2 SLC7A9 SLC13A3 SLC13A4 SLCO1C1 SLC5A12 SLC5A10 SLC13A5 AHCYL2 SLC35B4 SLC11A1 SLC22A6 SLC45A3 LCN15 LCN12 SLC5A5 MFSD4B-2 SLC22A11 SLC20A1 SLC31A1 SLC30A3 SLC30A2 SLC30A1 SLC41A2 SLC41A1 SLC2A6 SLC2A7 SLC50A1 SLC4A8 SLC4A9 SLC6A7 SLC6A9 SLC28A2 SLC29A1 SLC17A6 SLC28A3 SLC29A2 SLC2A8 SLC5A8 SLC25A18 SLC25A22 SLC25A11 SLC2A9 CALM3;CALM1 SLC34A2 SLC34A1 SLC40A1 HEPH SLC44A5 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 SLC11A2 SLC44A2 ARL2 APOD CP SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 SLC5A2 SLC33A1 SLC6A5 SLC26A4 SLC26A3 SLC6A2 SLC4A1 SLC22A12 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC25A5 SLC2A10 SLC25A4 SLCO1A2 SLC25A6 SLC22A8 SLC29A3 SLC24A4 SLC20A2 SLC35A2 SLC16A1 SLC24A5 SLC22A5 RSC1A1 SLC5A1-1 SLC2A2 SLC6A3 SLC22A18 SLC24A2 SLC24A3 SLC22A4 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC8A1 SLC8A2 FGF21 SLC30A8 SLC30A5 SLC35B3 SRI SLC35B2 SLC8A3 SLC35D2 SLC22A3 RUNX1 SLC17A8 SLC5A6 PDZD11 SLC35C1 SLC15A1 CTNS SLC15A3 SLC15A4 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A1 SLC12A6 SLC12A7 SLC35A1 SLC6A13 SLC17A5 SLC6A11 SLC22A2 SLC22A1 SLC6A1 SLC6A4 SLC4A7 SLC32A1 SLC8B1 SLC17A7 SLC26A11 AVP SLC26A2 SLC26A1 SLC25A10 SLC2A1 SLC2A13 SLC5A11 SLC5A3 SLC35D1 SLC4A2 SLC4A3 SLC35A3 SLC4A5 SLC5A9 SLC43A2 SLC30A10 SLC1A1 SLC5A4 SLC43A1 SLC2A4 ARL2BP SLC1A2 SLC2A11 SLC3A1 SLC2A12 SLC1A3 SLC24A1 SLC3A2 SLC39A10 SLC1A4 SLC7A11 SLC39A14 SLC1A5 SLC7A10 SLCO4A1 SLC16A7 SLC29A4 SLC16A8 SLC1A6 SLC6A20 EMB SLC7A1 SLCO4C1 SLC16A3 SLC28A1 SLC1A7 SLC7A3 SLC27A1 SLCO2B1 SLC25A29 SLC39A6 SLC38A3 SLC39A5 SLC38A2 SLC39A8 SLC36A4 SLC39A7 SLC38A5 SLC16A2 SLC38A4 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence SP1 MAPK1 MAPK3 CDKN2D CDKN2B CDKN2C CDKN2A AGO3;AGO1 ETS1 ETS2 UBA52 ERF TNRC6A-1 MDM2-2 TNRC6C TNRC6B ID1 RB1 RPS27A UBB;UBC MOV10 AGO4 TP53 E2F1 E2F2 E2F3 MDM4 TFDP1 CDK6 TFDP2 CDK4 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus NPM2 H1-8 HIRA H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 SRPK1 METTL23 H2BC1 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation CALM3;CALM1 PDE1C PDE1B PDE1A NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription EGR2 FOS NAB1 NAB2 ARC TRIB1 TPH1 RRAD EGR3 EGR4 FOSL1 ID3 ELK1 ID2-1 LYL1 F3 VGF ATF2 ASCL1 CHD4 FOSB CDK5R2 CDK5 ID4 CDK5R1 ID1 SH3GL3 JUND TCF12 REST SRF EP300 SGK1-1 ATF1 DNM2 EGR1 MEF2D JUNB C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT1 DAG1 POMT2 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways HBA2;HBA1 RNF213-2 PGK1 CALM3;CALM1 SNAP25 SV2C SYT2 CD9 SV2B UPK1A SYT1 UBA52 EPCAM SV2A VAMP1 STX1A VAMP2 HBEGF TXNRD1 EEF2 KPNB1 SH3GL3 SH3KBP1 NOS2 DUSP16 SRC CTNND1 RPS27A SFPQ-1 UBB;UBC STAM CBL CDH1 HGS CTNNB1 STAM2 MET EPS15 CBLL1 SH3GL2 GBP6 SH3GL1 GSK3A ATP6V1H MAP2K2;MAP2K1 MAPK1 GBP2;GBP3;GBP1 VPS33B MAPK3 HSP90AA1 ENO1 CTSG CORO1A GUCY2C TLR2 HSP90AB1 PDCD6IP PDZD3 MAP2K4 MRC1 B2M LTF KPNA1 TRIM27 RAB5A MAP2K7 HBD;HBB CASP5;CASP4 FURIN GBP7;GBP4 UBE2D3;UBE2D2 RAB7A RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes SOCS3 CBFB RUNX1 CTSV;CTSL SERPINB13 SOCS4 CTSK DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations POMK LARGE1 DAG1 MGAT5B-1 RXYLT1 POMGNT1 POMT2 B4GAT1 SLC35A1 FKTN SLC35A4 FKRP POMT1 B3GALNT2-2 LARGE2 POMGNT2 CRPPA CHST10 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome NCOR1 CAMK4 CALM3;CALM1 TBL1XR1 HDAC3 GPS2 PRKACA-1 SIN3A NCOR2 HDAC1 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLA2G12A PLA2G2E LPGAT1 PLA2G4D PLA2G3 PLA2G4F LPCAT4 PLA2G1B PLA2R1 LPCAT1 PLA2G5 CRLS1 PLA2G2A-1 PLA2G4A DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function RLBP1 RDH5 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance TERF2IP POLD2 RPA1 RPA2 H2AJ RPA3 TERF1-1 H2BC5 H2BC1 DSCC1 RUVBL2 SHQ1 PIF1 CTC1 CHTF18 H2AC4 STN1 TEN1 DAXX ATRX RUVBL1 POLR2A POLR2B POLR2C POLR2D CDK2 POLR2E POLR2F POLR2G PPP6C H2BC21 POLR2H POLR2I POLR2L PPP6R3 H2AZ2;H2AZ1 POLR2J;POLR2J2;POLR2J3 H2AC14 WRAP53 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TINF2 DKC1 NHP2 ANKRD28 RFC5 H2BC15;H2BC3;H2BC11;H2BC12 RFC3 RFC4 RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD FEN1 RFC2 LIG1 DNA2 H2AC20 RTEL1 BLM H2AB2;H2AB3;H2AB1 NOP10 PCNA PRIM2 CCNA2-1 POLD3 PRIM1 POLD4 WRN POLA1 TERT POLA2 TERF2 CCNA1 POT1 POLD1 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L NCBP2-1 GTF2H1 SUPT5H TCEA1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CTDP1 CCNH POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus FOXO1-1 RPS6KB2 AKT2 AKT3 AKT1 NR4A1 FOXO3 FOXO4 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones ATF4 NFYA-1 HSP90B1 ATF6 MBTPS2 MBTPS1 NFYB DDIT3 NFYC CALR-1 HSPA5 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 NPLOC4 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 ASCC2 RPS11 ASCC3 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBE2D1 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 VCP-1 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A LTN1 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A CUL2 RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ANKZF1 KLHDC10 TCF25 NEMF ZNF598 RPS27 ELOC-1 ELOB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RCHY1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 UBE2D3-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ABCE1 UFD1 RPL4 RPL30 RPL3 RPL32 UBE2D3;UBE2D2 RPL31 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense PGGT1B FNTB;CHURC1-FNTB CASP1 GBP2;GBP3;GBP1 PIM1 SFN FURIN ACTG1 GBP5-1 FNTA GBP7;GBP4 ACTB-1 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling NANOG;NANOGP8 JAK1 FOS RHOU OSM BATF IL4R MMP1 OPRD1 STAT1 STAT3 HSP90B1 POMC TNF IL12B IL12A ICAM1 TGFB1 CDKN1A LIF FOXO1-1 TNFRSF1B CCND1 ITGAM FCER2 CEBPD ITGB2 PIM1 IL10 ITGAX ANXA1 VEGFA STAT6 JAK3 POU2F1 TYK2 HSP90AA1 VCAM1 S1PR1 MAOA GATA3 LBP SOCS1 COL1A2 F13A1 OPRM1 VIM TIMP1 IL23R IL2RG HMOX1 IL6 MUC1 CXCL8 MMP2 JUNB BIRC5 ZEB1 JAK2 FASLG FOXO3 BCL2 BCL2L1 SOX2 RORC CD36 NOS2 TP53 HSPA8 SOCS5 IL4 SOCS3 CCL13;CCL2 IL13 ALOX5 HGF PTGS2-2 RORA LAMA5 LCN2 CCL11 FGF2 FN1 MYC AKT1 IL18 IL1A CCL22 IL1B ITGB1 PIK3R1 HIF1A IL17F ALOX15 IL17A MMP3 IL6R IL13RA2 IL13RA1 FSCN1 NDN MMP9 MCL1 SAA2;SAA1 IRF4 BCL6 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway OR8K3 OR8K1 OR4C11-1 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 OR2T2;OR2T35 OR6F1 OR51M1 OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 ANO2 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 OR51A7 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 EBF1 OR6Q1 OR52I1;OR52I2-1 OR11H1;OR11H12 OR4F21;OR4F16;OR4F29;OR4F3 OR9G9;OR9G1 OR7C1;OR7C2-9 OR51G2 OR51G1 OR2H2 OR1F1 OR4L1 OR5B3-13 OR10Q1 OR6P1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2B11 OR2AP1 OR4A47-3 OR51F2 OR2G6 OR5M9 OR51F1 OR4K5 OR4K3 OR4K2 OR5M3 OR4K1 OR10P1 OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 CNGA2 CNGA4 GNG13 GNB1 OR11H4 OR4C13;OR4C46-2 OR2M4 OR6K3-1 OR4K17 OR1K1 OR1S1;OR1S2 OR4Q3 OR11H6 OR8G1;OR8G5 OR11G2 OR1J4 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR1I1 OR2K2 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 ADCY3 OR14K1 OR4N5 OR5P3 OR5B17-3 LHX2 OR10C1 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 LDB1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 OR5T1 OR6V1 OR10G6 OR6C4-1 OR10K1-1 OR52W1 OR5AS1 OR4F5;OR4F17;OR4F4 OR2T6 OR13C9 OR13C8 OR2T1 OR4X1 OR2L13 OR9A4 OR51T1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 OR2Y1 OR8D4 OR8D1 OR56B4 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR10A4 OR56A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 GNAL OR4X2-2 OR2W3 OR8B8 OR2W1 OR8B4 OR13F1 OR12D3 OR5AU1 OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 OR52A5-2 OR2V2 OR8A1 OR11A1 OR10G9;OR10G7 OR8I2 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR56B1-1 OR8B3;OR8B2-1 OR10W1 OR5B2 OR5D14 OR5D13 OR52M1 OR10V1 OR4C12 OR5A2 OR6C3 OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 OR4D11 OR2Z1 OR4D10 OR6A2 OR9G4 OR4E1 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5AP2 OR5B12 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 OR4C3 OR3A2 OR3A1 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog CUL3 DERL2 OS9 SPOP GRK2 VCP-1 IFT172 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 SEL1L DYNC2H1 PRKAR2B RPGRIP1L IFT88 GSK3B P4HB KIF3A TTC21B ADCY4 HHIP PRKAR2A BOC GAS1 ADCY3 CDON ADCY2 GLI1 ADCY1 KIF7 ADCY8 GPR161 ADCY7 INTU PRKAR1A SMURF2 IFT122 TULP3 ADCY6 ERLEC1 SMURF1 FUZ ADCY10 ADCY5 MKS1 HHAT DISP2 SCUBE2 ULK3 IFT52 DZIP1 SPOPL NUMB IFT57 ARRB1 ARRB2 IFT140 PSMD8 WDR35 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 GPC5 PSMD12 PSMD11 PSMD14 PSMD13 GLI3 CUL1 GLI2 OFD1-1 PSMA7 WDR19 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 ADAM17 PSMB1 SYVN1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 IHH EVC2 PSMC4 EFCAB7 PSMC1 EVC GAS8 SHH NOTUM CDC73 GNAS-1 CSNK1A1 SMO DHH PTCH1 ITCH PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection PSTPIP1 CTSG C3-1 TXNIP HSP90AB1 CASP1 NT5E IL18 IL1A P2RX7 IL1B P2RX4 SUGT1 TXN RELA PYCARD C3AR1 ENTPD1 ENTPD5 NFKB1 MEFV GSDMD HMOX1 NFKB2 NLRP3 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC JMJD7-PLA2G4B;PLA2G4B PLBD1 PLA2G4A PLA2G4D PLA2G4F GPCPD1 PLA2G15 PLA2G4E PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors NLN MC2R PENK PPY MC4R CCR10 EDNRB CCR1 PPBP ACKR3-2 NPY4R2;NPY4R CX3CL1 CCR9 EDN1 CCR8 CCR7 EDN3 CCR6 CCR4 CCR3 CCR2 GAL MC3R OPRD1 NPB CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH POMC MAS1 MC1R XK NPY2R C3AR1 CCRL2 NPY1R MC5R APLNR PYY CXCL9 HEBP1 C5AR2 C5AR1 GPER1 ANXA1 MCHR1 NPY5R SSTR1 SSTR2 NPY SSTR4 SSTR5 OPRL1 CXCL12 ACKR4 ACKR2 ACKR1 CENPS-CORT;CORT;CENPS CXCR4 OPRM1 OPRK1 CXCL8 SSTR3 NPFFR2 NPFFR1 GRPR EDNRA RXFP4 PROK2 PROK1 RLN3 UTS2R RLN2;RLN1 NPFF INSL3 RXFP1 TRHR APP UTS2B INSL5 RXFP2 AGTR1 RXFP3 FPR2 HCRT NTSR1 NTSR2 CCR5 NMB XCR1 XCL1;XCL2 NMBR OXTR NMS NMU AVPR1B AVPR2 QRFP AVP MLN AVPR1A BRS3 OXT-1 CCKAR EDN2 TACR2 TACR3 TACR1 F2 MRGPRD CCKBR NPSR1 PDYN GRP AGTR2 FPR1 CCL13;CCL2 GALR3 NPS GALR2 PROKR1 GALR1 PROKR2 NPBWR1 KISS1R NPBWR2 C5 PNOC C3-1 AGT GPR37 F2RL1 F2RL2 CXCL2;CXCL3;CXCL1-1 F2RL3 PMCH CCL11 CCL4L2;CCL4L1;CCL4 GHSR CCL19 F2R CCL17 CCL16 NTS CCL25 PF4;PF4V1-1 MCHR2 KNG1 CCL22 TAC3 CX3CR1 CCL21 TAC1 CCL20 NMUR2 NMUR1 CCL28 MLNR CCL27 TRH CXCL13 BDKRB2 BDKRB1 QRFPR CCL3L1;CCL3L3;CCL3;CCL18 PSAP CXCL10 CXCL11 ECE1 PRLHR CCL5 CCL1 CCK APLN ECE2;EEF1AKMT4-ECE2 HCRTR2 HCRTR1 KISS1 CXCL5;CXCL6 SAA2;SAA1 GPR37L1 KEL SST CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions ITGA10 HSPA8 ANK1 ITGA2 ITGA1 CHL1 NRP1 CNTN6 ITGB1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases PPP1R12A OPTN-1 AKAP9-1 FBXL7 PLK1 PKMYT1 PPP1CB CCNB1 CDK1 NEK2 CCP110 PRKACA-1 CDKN1A CEP250 FZR1 CDK5RAP2 CEP135 E2F1 CSNK1D PRKAR2B E2F3 TPX2 CDK2 PPP2R2A;PPP2R2D HSP90AA1 YWHAG CEP70 FOXM1 PPP2R1B CEP72 PPP2R1A CEP192 SGO1 CEP76 HSP90AB1 CEP78 PLK4 ODF2 RBBP4 CCNB2 AJUBA CEP57 CETN2 CEP164 MYBL2 ACTR1A AURKA PPP2CB;PPP2CA MAPRE1-1 CNTRL XPO1 EP300 CDK11A;CDK11B PPME1 BORA CEP290 OBI1 RAB8A LCMT1 CCNA2-1 TICRR CKAP5 CCNA1 HAUS4 GTSE1 PAFAH1B1 FKBPL HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 PSMD8 HJURP HAUS2 PSMD6 HAUS1 PSMD7 MIS18BP1 PSMD2 CLASP1 PSMD3 PSMD1 BTRC DYNC1H1 SKP1 NDE1 CEP63 CENPF FBXW11 YWHAE PSMC2-1 PSMA5 TUBA1A PSMA6 DCTN2 PSMA3 SSNA1 CENPJ CDC25C PSMA4 DCTN3 PSMA1 UBA52 CDC25A PSMD12 HAUS8 FBXL18 CDC25B PSMD11 HAUS7 PSMD14 PSMD13 PCNT CUL1 OFD1-1 CEP152 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 NEDD1 PSMB2 TUBA4A PSMB3 ALMS1 PHLDA1 PSMB1 RPS27A UBB;UBC ADRM1 CEP41 RBX1 PSMA2-1 CEP43 TP53 SEM1 PSMC5 PSMC6 PPP2R3B PSMC3 PSMC4 TUBGCP2 HMMR PSMC1 MZT2A;MZT2B CCNH TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 TUBG2 NME7 MZT1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CDK7 MNAT1 LIN54 LIN52 LIN37 LIN9 WEE1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects PDE10A KCNMB2 KCNMB3 KCNMB4 PDE5A PRKG2 KCNMB1 KCNMA1 IRAG1 PDE9A PDE2A PDE1B PDE1A ITPR1 PDE11A DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations POMT1 DAG1 POMGNT1 POMT2 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases TAB1 RNF123 USP14 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 CLSPN RCE1 IL33 SIAH2 USP18;USP41 WDR48 H2BC5 H2AC16;H2AC11 POLB H2BC1 USP30 H2AC4 CCP110 RHOT1 HGS STAM2 SKP2 PTRH2 USP21 USP4 H2BC21 CYLD TOMM70 CDC20 SUDS3 ATXN7 GATA3 SMAD2;SMAD3 SMAD1 SMAD4 SMURF2 USP33 SMAD7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SNX3 MDM2-2 USP13 TNKS TNKS2 H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 RNF146 OTUB1 MDM4 TGFBR1-1 CCNA2-1 H2BC18 RNF128 DDB2 ARRB1 USP15 ARRB2 CCNA1 TADA2B TAF10 BECN1 PSMD8 WDR20 PSMD6 USP8 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG USP9X MAP3K7 IDE PSMC2-1 USP5 PSMA5 USP3 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CFTR CDC25A FKBP8 PSMD12 PSMD11 AXIN2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 VDAC2-1 PSMB5 PSMB2 VDAC3 PSMB3 PSMB1 RPS27A VDAC1 UBB;UBC KAT2A ADRM1 PSMA2-1 TP53 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 TADA3 RUVBL1 MUL1 FOXO4 TRRAP MAT2B AR USP37 USP47 USP48 USP49 USP42 H2AC14 DDX58 USP44 IFIH1 MYC USP34 USP26;USP29 USP7 USP16 TRAF2 USP2 USP24 PTEN USP25 USP20 UFD1 USP22 USP28 TOMM20 HIF1A BIRC2 USP10 BIRC3 RIPK1 KEAP1 H2AC20 ADRB2 TRAF6 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCA3 ABCD2 PEX19 ABCD3 PEX3 ABCG1 ABCG4 ABCA2 ABCA5 ABCA9 ABCA7 ABCG8 ABCG5 ABCA6 ABCA12 ABCD1 APOA1 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes TAF13 TAF11 CDK9 NCBP2-1 CCNT2-1 TAF8 TAF6 TAF5 NABP1-1 INTS1 SNAPC5 INTS3 SNAPC1 INTS2 SNAPC2 INTS5 SNAPC3 INTS4 SNAPC4 INTS7 ZNF143 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B PHAX RPRD1A POU2F2 POLR2A POLR2B POLR2C POLR2D POLR2E POU2F1 SP1 POLR2F SRRT POLR2G POLR2H POLR2I POLR2L SUPT5H GTF2F1 GTF2F2 CDK7 POLR2J;POLR2J2;POLR2J3 PCF11 CCNK CCNT1 ELL GTF2B TBP NCBP1 GTF2A1 GTF2A2 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR NFKB1 NGFR PSENEN RELA PSEN2 PSEN1 APH1A NCSTN APH1B TRAF6 ADAM17 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response CASP7 CASP3 CASP9 APAF1 DIABLO-1 XIAP CYCS-1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes ANGPTL8 ANGPTL3 ANGPTL4 MBTPS2 LPL LMF2 LMF1 LIPC FGF21 GPIHBP1 CREB3L3 FURIN PCSK6 MBTPS1 PCSK5 APOC2 APOA4 APOA5 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling GNB1 GNB4 GNB3 GNB5 EGFR FOS CALM3;CALM1 ZDHHC7 ZDHHC21 TGFA CAV2 MMP7 EGF ELK1 FOXO3 BCL2 UHMK1 AREG EREG BTC EPGN HBEGF GNAT3 SPHK1 SRC CAV1 CDKN1B CCND1 GNGT1 PRMT1 NRAS PTK2 MAPK1 HRAS MAPK3 HSP90AA1 ESR1 PDPK1 S1PR3 PIK3CA GNAI3 PRKCZ GNAI1 AKT2 GNAI2 AKT3 STRN AKT1 ESR2 GNG10 IGF1R GNG2 GNG5 GNG4 GNG8 PIK3R3 PIK3R2 PIK3R1 MMP3 NOS3 XPO1 SRF MMP2 MMP9 GNG13 GNB2 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 TLR3 OPTN-1 TICAM1 IRF7 TANK TRAF3 IKBKE UBA52 RPS27A TBK1 UBB;UBC IRF3 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 PHF5A PPP1CB SNRPN HNRNPU CHERP PPP1CA PAPOLG CPSF4 PTBP1 SNRPA1 DNAJC8 PUF60 SNRPB2 DHX9 SRRM2 DDX5 HNRNPH1 HNRNPH2 TCERG1 SNRPC SNRPA PPP1R8;STX12 HTATSF1 RBM25 PPP1R10 CPSF2-1 CPSF1 SNRNP70 CSTF3 PRPF40A CPSF3 TUT1 CSTF2 SRSF10 CSTF2T SRSF12 WDR33 TRA2B RBM39 NUDT21 PABPN1-1 CLP1 PCF11 RBBP6 PAPOLA SYMPK CPSF7 RBM5 YBX1 HNRNPC RBMX NCBP1 U2AF1L5;U2AF1 EIF4A3 CASC3 THOC1 THOC3 THOC2 THOC5 CDC40 NCBP2-1 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A POLDIP3 SRSF1 U2AF2 FYTTD1-1 DHX38 UBA52 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 XRN2 RPS27A UBB;UBC SNRPD2 SNRPD1 SNRPD3 SNRPF POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 POLR2F SRRT POLR2G POLR2H POLR2I POLR2L GTF2F1 FUS GTF2F2 POLR2J;POLR2J2;POLR2J3 HNRNPA3 CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 FIP1L1 HNRNPA2B1 DDX46 DDX42 RBM17 SMNDC1 U2SURP HNRNPR ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS NTRK3 HRAS SOS1 NTF3 NRAS INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production KPNB1 NOS2 KPNA1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines CCR10 CCR1 PPBP ACKR3-2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 CXCR5 CXCR6 CXCR1 CCR5 CXCR3 CXCR2 XCR1 XCL1;XCL2 CCRL2 CXCL9 CCL13;CCL2 CXCL2;CXCL3;CXCL1-1 CCL11 CXCL12 ACKR4 ACKR2 CCL4L2;CCL4L1;CCL4 CCL19 CCL17 CCL16 CCL25 PF4;PF4V1-1 CCL22 CX3CR1 CCL21 CCL20 CCL28 CCL27 CXCR4 CXCL13 CCL3L1;CCL3L3;CCL3;CCL18 CXCL10 CXCL11 CCL5 CCL1 CXCL8 CXCL5;CXCL6 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis SRD5A3 POMC CGA HSD3B1;HSD3B2 HSD17B3 HSD17B12 SRD5A2 SRD5A1 LHB CYP17A1 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT1 DAG1 POMT2 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP1BB GP5 VWF ADAMTS13 GP1BA GP9 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHB DBT DLD BCKDHA REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity DIO1 DIO3 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase DKC1 TERF2IP ANKRD28 NHP2 PPP6C RUVBL2 SHQ1 PIF1 PPP6R3 ACD TERF1-1 RTEL1 WRAP53 NOP10 CCNA2-1 TINF2 TERT RUVBL1 TERF2 CCNA1 CDK2 POT1 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) H2BC21 BARD1 BRCC3 TP53BP1 BABAM1 RAD50 BABAM2 UIMC1 ABRAXAS1 UBE2V2 RNF8 DCLRE1C RNF168-1 RIF1 NSD2 ATM LIG4 PAXIP1 NHEJ1 XRCC4 MRE11 BRCA1 TDP2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TDP1 KAT5 H2BC5 POLL NBN H2BC1 POLM H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PRKDC HERC2 MDC1 XRCC6 PIAS4 XRCC5 UBE2N SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy DUSP16 RAB7A GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation NANOG;NANOGP8 TEAD2 POU5F1;POU5F1B TRIM33 TEAD4 ZIC1 PAX3 SNW1 FOXF1 TCF7 CDH1 SNAI1 CTNNB1 FOXA1 FOXH1 RBPJ MAMLD1 GATA4 LEF1 SMAD2;SMAD3 SMAD4 LFNG TFAP2A EOMES GATA6 TFAP2C TBXT SOX17 YAP1-1 GSC MIXL1 TCF7L2 TCF7L1 CXCR4 MAML2 HES7 MAML1 TBPL2 EP300 EPHA4 MESP2 MSGN1 RIPPLY2 MYB PAX7 DLL3 NOTO MSX1 CREBBP FGFR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMD12 PSMD11 PSMD14 PSMD13 SOX2 ZEB2 SOX1 PSMA7 FGF8 NOG PSMB6 GBX2 OTX2 PSMB7 DLL1 PSMB4 TBX6 POU3F1 PSMB5 ZNF521 PSMB2 PSMB3 PSMB1 KAT2B KAT2A ADRM1 NOTCH1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 IHH PSMC4 PSMC1 DLX5 SHH FOXC2 FOXC1 FGF2 FGF4 TFAP2E;TFAP2B OSR1 PAX2 BMP4 ZIC2 PAX6 PAX8 LHX1 FOXA2 WNT3A RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR2E POU2F1 POLR3E POLR2F POLR1C POLR3F POLR2H POLR1D POLR3G POLR2L POLR3H BDP1 POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 CRCP TBP POLR3GL POLR3A POLR3B POLR3C POLR3D REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements DNMT3L SPOCD1 C19orf84 PIWIL4 SMARCB1 TRIM28 MPHOSPH8 H2AJ SMARCC1 MBD3 ZNF382 SMARCC2 ZNF669;ZNF670 GATAD2B SMARCD1 GATAD2A HDAC2 SMARCD2 H2BC5 HDAC1 H2BC1 SMARCA2 SMARCE1 SMARCA4 ZCCHC8 MTA1 MTA3 H2AC4 RBM7 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 PPHLN1 TASOR ATF7IP SETDB1 UBE2I H2BC21 H2AZ2;H2AZ1 ZNF331 ACTB-1 ZNF354A;ZNF354B-4 SUMO2 EHMT2 EHMT1 ZNF324B;ZNF324 H2AC14 CBX5 RBBP4 MTREX H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 ZNF649 ZNF317 CHD4 ZNF30 CHD3 SMARCD3 H2BC15;H2BC3;H2BC11;H2BC12 ARID1A ARID1B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA2 ZNF264;ZNF805-1 BCL7A BCL7C DPF1 MORC2 BCL7B H2AC20 DPF2 DPF3 SS18 H2AB2;H2AB3;H2AB1 SS18L1 ACTL6A DNMT3A SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins HRAS PIK3R1 MYO18A PIK3CA CDKN1A GOLGB1 TRIP11 STAT5A STAT5B SOS1 PIM1 NOX4 GAB2 SPTBN1 NRAS ZMYM2 ETV6 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction KCNK5 KCNK12 KCNK15 PAK1 AKAP9-1 PAK2 ALDH2 KCNIP3 ACTN2 GATA4 TMOD3 PDE5A VIM TTN-1 PXN TLN1 VCL CALM3;CALM1 NPR1 NPR2 NPPC CORIN DMD TNNI1 TNNI2 TMOD1 MYBPC3 MYBPC1 MYBPC2 ACTN3 TMOD4 TNNC1 TNNC2 TMOD2 NEB MYL4 DES MYH3 TNNT1 MYL1 TNNT2 MYL2 CACNA1C MYL3 CACNG6 TNNT3 FGF14 MYH8 RANGRF TCAP FGF13 FGF12 MYH6 FGF11 KCNH2 KCNK10 KCNK13 KCNK16 KCNK18-1 KCNK17 KCNQ1 TBX5 KCNK9 KCND1 KCND2 KCND3 KCNA5 KCNJ14 RYR1 RYR2 KCNK2 AHCYL1 KCNK3 ATP2A3 ATP2A2 ATP2A1 KCNK4 RYR3 TRIM72 GUCY1B1 SLC8A1 SLC8A2 ITGB5 PRKACA-1 DYSF LMOD1 NOS1 MYL6B CLIC2 CACNA1H ABCC9 MYL12A ATP1B2 ATP1B1 CACNA1G MYL12B TRDN MYLK ASPH STIM1 CACNA1I ORAI2 CALD1 ORAI1 ANXA6 MYL10 CAMK2B MYH11 CAMK2D GUCY1A2 CAMK2A GUCY1A1 ATP1A4 ANXA1 ITPR1 MME ITPR2 CAV3 TPM4 ATP1A3 ANXA2 TPM3 ATP1A2 TPM2 ITPR3 CES1 TPM1 SRI SORBS1 ATP1A1 SORBS3 TNNI3 MYLPF CAMK2G MYL5 KCNJ11 MYL6 DMPK MYL7 NPPA ATP1B3-1 ATP2B4 ATP2B3 FXYD2;FXYD6-FXYD2 ATP2B2 ATP2B1 SLC8A3 FXYD4 FXYD3 FKBP1B FXYD1 FXYD6 SCN11A SCN9A SCN5A SCN1B SCN1A CACNG7 SCN10A SCN8A SCN4A SCN4B SCN7A SCN3B SCN3A SCN2A SCN2B NKX2-5 KCNE2 KCNE3 KCNE4 KCNE5 KCNE1;KCNE1B CACNA2D2 KAT2B CACNB1 CACNB2 TRPC1 CACNG8 HIPK1 HIPK2 KCNJ2 CACNG4 KCNJ12;KCNJ18 KCNJ4 KCNK6 KCNK7 KCNK1 ITGA1 KCNIP1 KCNIP2 KCNIP4 WWTR1 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 BCKDHB DBT DLD BCKDHA COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation MOV10 AGO4 TNRC6C AGO2 TNRC6B TNRC6A-1 AGO3;AGO1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle STEAP3 BAIAP2L2 ARHGAP21 AKAP12 SENP1 ACTB-1 MCAM ARHGAP39 RHOF SNAP23 SRGAP2 VANGL1 SYDE1 ARHGAP32 DIAPH3 BAIAP2L1 BASP1 ESYT1 SOWAHC TOR1AIP1 ARHGAP12 LMNB1 CAPZB ACTN1 SLC4A7 ARHGAP1 PIK3R2 PIK3R1 ARHGAP5 DIAPH2 FARP1 MYO9B CAV1 TMPO ADD3 FAM169A DEPDC1B MTMR1 DIAPH1 VAMP3 RAB7A DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 CDKN2A TP53 YWHAE CAST C1QBP APP JUN FASLG CDC25C SOD2 FOXO3 CDC25A LMNB1 CDC25B GOLGA2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists LRP6 WIF1 WNT5A WNT9A WNT4 DKK1 DKK2 DKK4 WNT3A SFRP1 SFRP2 SOST KREMEN1 KREMEN2 LRP5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import TIMM23 SLC25A13 TIMM22 TIMM21 NDUFB8 ATP5MC1 TOMM40 TIMM13 ATP5F1A COQ2 TIMM10 ATP5F1B CHCHD3 CHCHD10-1 SAMM50 TIMM8B TIMM8A IDH3G HSPA9 GFER MTX1 TOMM7 CHCHD7-1 MTX2 PMPCB VDAC1 PMPCA HSCB GRPEL1 BCS1L CYC1 FXN TOMM70 OTC TOMM20 TOMM22 CHCHD4 CHCHD5 TIMM17A-1 CHCHD2 CMC2 COX19 SLC25A4 COX17 SLC25A6 TIMM50 HSPD1 PITRM1 LDHD GRPEL2 COA4 DNAJC19 TIMM44 TIMM10B CS ACO2 TAZ TIMM17B SLC25A12 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport YWHAH LNPEP GRK2 YWHAZ PLA2G4A HSP90B1 COLEC11 SH3GL3 SH3KBP1 STAM MASP1 CBL HGS STAM2 SPARC EPS15 SH3GL2 SH3GL1 INS;INS-IGF2 YWHAB STXBP3 ARFGAP2 MCFD2 SERPINA1 PPP6C TFG PPP6R1 PPP6R3 CTSC RAB27B TMED2-1 TRAPPC2L ITSN2 TRAPPC2;TRAPPC2B RALA-1 LMAN1L SCARB2 F5 AGFG1 GAPVD1 TRAPPC6A F8 STON1-GTF2A1L BIN1 TBC1D20 AMPH TRAPPC6B SNX18-1 GPS1 GORASP1 PREB GRK3 CLTCL1 SEC22B SEC22A PACSIN2 SEC22C PACSIN3 RAB1A SNX9 PIP5K1C TMED10 KIAA0319 STX17 MYO6 LMAN2L PACSIN1 TOR1A RAB1B SYNJ2 GOSR2 USO1 TOR1B SCFD1 SYT9 LMAN2 SYT8 SNAP91 CD59 DAB2 SEC31B COPS4 SEC31A IL7R ANKRD28 PICALM STON2 TRAPPC3 COPS2 TRAPPC1 PIK3C2A TRAPPC4 SLC2A8 TRAPPC10 SGIP1 GJB1 EPS15L1 TRAPPC5 HBD;HBB TRAPPC9 ARFGAP1 SEC23IP EPN1 CNIH1 EPN2 GAK CRYZL2P-SEC16B;SEC16B CNIH2 CTTN ARF6 FOLR1 CNIH3 LRP2 FCHO1 BET1 ALS2 FCHO2 REPS2 UBQLN1 UBQLN2 HIP1R NECAP2 APOB NECAP1 SYT11 TRIP10 MAN1A2 GJA3 MAN1C1 GJA5 MAN1A1 GJA4 ARRB1 GJA9 GJA8 GJC2 ARRB2 APOA1 GJB4 GJB3 DENND1C TSC2 GJB6 DENND1B TSC1 HBA2;HBA1 GJB5 GDI1 GJB7 DENND5B DENND1A GJD4 MAP1LC3B2;MAP1LC3B-1 GJD3 GDI2 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 CALM3;CALM1 DENND6B RIN3 RAB38 YWHAE DENND6A APP RIN1 RIN2 RAB21 SYT2 ALS2CL CHML SYT1 CCZ1;CCZ1B ANKRD27 CPD DENND4B VAMP2 DENND4A SH3D19 GOLGA2 DENND4C TPD52 HPS1 TFRC HPS4 AP3S2;AP3S1 BLOC1S4 RAB39A BLOC1S6 RAB39B TRAPPC8 SNX2 PRDX1 BLOC1S3 RAB18 SNX5 RAB3GAP2 FTH1 TBC1D8B MON1A SNAPIN RAB3GAP1 MON1B SORT1 DTNBP1 SEC23A PUM1 TPD52L1 SAR1B GOLGB1 YIPF6 ACBD3 SEC24B HYOU1 SEC24A SEC24D-1 WNT5A SEC24C FTL-1 TF KDELR3 DCTN1 SNAP23 KDELR1 OCRL CHMP4C CHMP4B CHMP3 CHMP4A DCTN6 DCTN5 CHMP6 DCTN4 BICD1 RACGAP1 CD55 CHMP7 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 HMGB1-1 CHRM2 FZD4 ADRB2 COL3A1 CHMP2B CHMP2A COL4A2 COL4A1 COL7A1 CLINT1 AP2A1 AP2A2 LDLRAP1 AP2M1 AP2S1 LDLR DVL2 AP2B1 VPS45 ALB MYO5A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1A WASL ARF5 ACTR2 ARCN1 DYNC1LI1 DYNC1LI2 ZW10 KDELR2 MYO1C GNS MIA2 KIF18A STAB2 SEC13 GOSR1 SYNJ1 KIF2A KIF2C KIF2B PAFAH1B1 DYNC1I2 COPZ2 COPZ1 DYNC1I1 COLEC12 MSR1 DYNC1H1 SCARA5 MARCO SCGB3A2 CENPE RAB30 RAB36 FNBP1L EGF FNBP1 GALNT2 AREG NSF GRIA1 CD36 BET1L LRP1 AVPR2 AVP TJP1 SBF1 SCARF1 TMED3 TMED7 TMED9 COPG2 COPG1 COPB2 COPA COPB1 MAN2A2 TMEM115 COPE ALPG;ALPP;ALPI-1 AKT2 AKT3 AKT1 PRKAB2 PRKAB1 C2CD5 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 RAB10 RAB14 RAB13 RAB27A SAA2;SAA1 PRKAG1 PRKAG2 CD3G CD3D PRKAG3 RAC1 GOLIM4 CYTH3 CYTH2 CYTH4 GOLGA5 SNAP29 CYTH1 OPTN-1 MAN2A1 HPX AP3B1 AMBP HP;HPR JCHAIN KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KIF6 KIF27 RINT1 KIF9 KIFC2 ARF4-1 KIFC1 KIFAP3 KIF16B KIF20B NBAS STX18 BNIP1 CSNK1D SURF4 KIF18B CD163 COPS5 KIF26B MYH9 GALNT1 KIF3B KIF3A YWHAG KIF3C PRKAA2 HIP1 RAB3IP SFN AGPAT3 COL1A1 COL1A2 CD4 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 ACTR1A VTA1 VPS37C VPS37D RABGAP1 GABARAP VPS37A SNF8 GGA2 GGA1 VPS37B RABGEF1 UBAP1 VPS25 GGA3 VPS28 TBC1D13 TBC1D10C CHMP5 TBC1D14 TBC1D17 TBC1D10A TBC1D15 TBC1D10B RAB8A RAB8B TBC1D16 GABARAPL2 EXOC8 RAB4A SYTL1 RAB33A EXOC7 RAB33B-1 RAB11B TBC1D2 RABEP1 TBC1D7;TBC1D7-LOC100130357 RAB35 TBC1D24 TBC1D25 EGFR ULK1 RAB7B PLA2G6 EXOC4 EXOC3 GJA1 EXOC6 GJB2 EXOC5 EXOC2 EXOC1 DCTN2 DCTN3 CFTR GBF1 RAB11A MIA3 TRIP11 APOL3;APOL4;APOL1;APOL2 CD5L SSC5D S100A9 NAPA USP6NL NAPB SCOC TMF1 SYS1 STX16 ARL1 RHOBTB3 GCC2 GCC1 RABEPK NAPG STX10 TGOLN2 ARFRP1 GOLGA4 VPS51 VPS53 VPS52 GOLGA1 VTI1A RAB5B STX6 RAB5C VPS54 ARFIP2 RAB6A RAB5A RAB6B ITSN1 NAA30 COG8 COG7 RIC1 COG6 COG5 CUX1 COG4 COG3 COG2 COG1 IGF2R RGP1 NAA35 RAB9A NAA38 VAMP4 KIF20A KLC1 RAB9B GJD2 KLC4 GJC1 KLC3 ARFGAP3 KLC2 GJA10 KIF11 KIF15 CALR-1 VAMP3 KIF23 RAB7A KIF22 KIF26A LMAN1 STX5 YKT6 TGFA APOE PLIN3 STAB1 KIF5B KIF5A CLTC CLTA HSP90AA1 STX4 SPTAN1 CAPZB KIF4B;KIF4A ANK2 ANK3 ANK1 SPTB YWHAQ DNM1 DNM3 CAPZA1 CAPZA2 SPTBN4 SPTBN5 SBF2 SPTA1 SPTBN1 SPTBN2 AGTR1 UBA52 EREG CHM BTC EPGN HBEGF SLC18A3 ARF1 CTSZ CLTB RAB3A AP4E1 HSPH1 AP4M1 AP1G2 BLOC1S1 RPS27A UBB;UBC CLVS2 AP4S1 CLVS1 TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 TACR1 COPS7B COPS7A COPS3 COPS6 COPS8 AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex RPA1 RPA2 POLE4 CDC6 RPA3 POLE2 POLE3 CDC7 POLE GMNN CDT1 MCM10 CDC45 MCM7 ORC5 ORC4 DBF4 ORC6 ORC1 MCM3 MCM8 MCM4 ORC3 MCM5 ORC2 MCM6 MCM2 PRIM2 PRIM1 POLA1 POLA2 CDK2 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine CBS;CBSL CTH DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) GCKR NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 GCK SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LRP5 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade CPN1 C8G C6 C7 CD19 C9 C5 CR2 C3-1 CFHR1;CFHR2 LOC110384692;C4A;C4B_2;C4B SERPING1 CFH-3 CFB C2 CR1L;CR1 VTN PROS1 CD59 CRP CD55 CFD C1QB COLEC11 C3AR1 COLEC10 C1S C1R FCN2;FCN1 MBL2-1 MASP1 C1QC ELANE CPB2 CD81 C5AR2 CFI C5AR1 C4BPA C4BPB F2 C8B C8A CLU CPN2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation POLD2 RPA1 RPA2 RPA3 RFC5 RFC3 RFC4 RFC1 FEN1 GINS1 RFC2 GINS2 CDC45 MCM7 LIG1 GINS3 GINS4 MCM3 MCM8 MCM4 DNA2 MCM5 MCM6 MCM2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway IFNB1-4 TBK1 IRF3 EP300 DDX58 IFIH1 RNF135 IRF7 SIKE1 TRAF3 MAVS TRIM25 IKBKE CREBBP DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTSL3;ADAMTSL1 ADAMTSL1 ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON ADAMTS20 B3GLCT CFP THBS2 THBS1 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases DUSP6 MAPK1 DUSP7 MAPK9 MAPK3 MAPK8 MAPK7 RPS6KA1 PPP2R1B FOS MAPK14 PPP2R1A MAPK10 MAPK11 MAPKAPK2 RPS6KA3 RPS6KA2 JUN RPS6KA5 ELK1 ATF2 PPP2CB;PPP2CA ATF1 PPP2R5D DUSP4 MEF2C MEF2A DUSP3 VRK3 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body ABCC1 LDLRAP1 ABCD4 TCN1 CD320 TCN2 LMBRD1 LRP2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses GNS HYAL1 GLB1 GALNS NAGLU SGSH HGSNAT IDS IDUA GUSB ARSB DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol CYP27A1 HSD3B7 AKR1D1 NR1H4 CYP7B1 CYP7A1 RXRA AMACR ABCB11 SLC27A5 ACOT8 NCOA1 NCOA2 HSD17B4 CYP8B1 BAAT SLC27A2 ACOX2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction RBP1 OPN1SW TTR RLBP1 LRAT NAPEPLD OPN1MW3;OPN1MW2;OPN1MW;OPN1LW STRA6 RDH12 RBP4 ABCA4 RDH5 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer HBEGF CDC37 HRAS HSP90AA1 PIK3R1 PTPN12 EGFR PIK3CA ERBIN ERBB2 GAB1 NRG2 NRG3 SOS1 NRG4 SHC1-1 PLCG1 EGF NRG1 EREG BTC NRAS THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism RIDA SDS SDSL TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex E2F4-1 TOP2A LIN54 LIN52 LIN37 RBL2 LIN9 RBL1 CDC6 E2F1 E2F5 RBBP4 MYC PCNA TFDP1 MAX TFDP2 CDC25A HDAC1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway GNAT3 ADCY4 GNAI3 GNAL ADCY9 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 GNAI2 ADCY5 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation EIF3F EIF3D EIF3A EIF3B QARS1 RARS2 RARS1 AARS2 PARS2 MARS2 MARS1 DARS2 YARS2 ASCC2 HARS2 ASCC3 FARS2 WARS2 LARS2 GARS1 DARS1 SARS2 PPA2 LARS1 NARS2 TARS2 UBE2D1 EEF1E1 IARS2 VARS2 KARS1 CARS2 EARS2 VCP-1 IARS1 AIMP1 AIMP2 EPRS1 LTN1 DDOST APEH ANKZF1 KLHDC10 TCF25 NEMF ZNF598 ELOC-1 ELOB MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 EIF4EBP1 MRPL9 C12orf65 CHCHD1 TARS1 MRPS28 EIF4E AARS1 TSFM RCHY1 EIF4B HARS1 MRPS26 FARSA MRPS27 FARSB MRPS24 MRPS25 MIEF1 MRPS22 MALSU1 MRPS23 MTFMT MRPL49 YARS1 EIF4G1 MRPS18B NARS1 MRPS21 PPA1-1 CARS1 MRPS2 VARS1 MRPS18A MTIF2 MRPL47 MTIF3 MRPL48 WARS1 MRPS7 MTRES1 MRPL46 MRPS6 MRPS5 MRPL43 TUFM MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS36 MRPS33 MRPL18 MRPS34 MRPL19 MRPS31 MRPL16 RBX1 MRPS35-1 MRPL17 MRPL58 MRPL14 MRPS30 SRPRB-1 MRPL15 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 LOC107987373;MRPL23 MRPL30 SSR1 SRPRA UFD1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 EIF5 RPS16 NPLOC4 EIF5B RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 SEC11A SEC11C RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A CUL2 GSPT2 GSPT1 RPL13A-1 RPL11 RPS27L RPS15A SPCS3 RPL14 SPCS2 RPS3 SPCS1 PABPC1;PABPC3 RPL13 RPL12-1 RPS2 RPL18 SEC61A2 RPL17 RPL19 SEC61A1 SEC61G RPL35A SEC61B RPL23A RPL22L1 FAU RPL26L1 ETF1 NDUFAB1 RPS27 SARS1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 EEF1B2-1 PSMD13 EEF1G EEF1A1 UBE2D3-1 EEF1D EEF1A2 PSMA7 EEF2 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 N6AMT1 ABCE1 TRMT112 SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 EIF2B5 SSR3 EIF2B4 SRP9 EIF2B3 SRP72 EIF2B2 RPN2 SRP68 EIF2S2 EIF2S3;EIF2S3B EIF2B1 RPN1 EIF2S1 GFM2 MTRF1 MTRF1L MRRF EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J UBE2D3;UBE2D2 EIF3G EIF3H EIF3E ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress ATRIP RPA1 RPA2 CLSPN CDC6 RPA3 RAD17 CDC7 RAD1 RAD9B RAD9A ATR CDC25C CDC25A CHEK1 RFC5 RFC3 RFC4 RFC2 MCM10 CDC45 HUS1 MCM7 ORC5 ORC4 DBF4 ORC6 ORC1 MCM3 MCM8 MCM4 ORC3 MCM5 ORC2 MCM6 MCM2 CDK2 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CDK5 PPP1CA PPP1CC TPTEP2-CSNK1E;CSNK1E CSNK2A1;CSNK2A3 PER2 PER1 CRY2 CSNK1D CRY1 CSNK2A2 CSNK2B PPP1CB SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF RAC1 VAV1 RASA1 ELMO1 CDH5 PAK1 PTK2B RICTOR PRKCD PAK3 PAK2 CYFIP2 AHCYL1 CTNNA1 CAV1 PRKACA-1 CTNND1 PRKACB-1 PGF THEM4 CTNNB1 SHC2 VAV3 ITPR1 VEGFA ITPR2 PRR5 ITGAV NRAS ITPR3 PTK2 PIK3CB VAV2 HRAS MLST8 HSP90AA1 PRKCA PDPK1 MAPK14 PIK3CA MAPK12 MAPK13 MAPK11 ROCK1 NRP2 ROCK2 MAPKAPK3 MAPKAPK2 CDC42 CRK NRP1 NCK2 NCK1 FYN WASF3 VEGFB VEGFC VEGFD MTOR ITGB3 PXN AAMP BCAR1 FLT4 HSPB1 CALM3;CALM1 PRKCB PLCG1 SPHK1 JUP NCKAP1 WASF1-1 NCF1 NCF2 PRKCZ NCF4 RHOA AKT2 AKT3 AKT1 CYBB TRIB3 CYFIP1 CYBA MAPKAP1 AXL KDR PIK3R2 PIK3R1 NCKAP1L SHB WASF2 NOS3 BAIAP2 ABI2 ABI1 ELMO2 FLT1 DOCK1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation SLC32A1 SLC6A12 ALDH5A1 RAB3A RIMS1 HSPA8 ABAT GAD1 SNAP25 GAD2 SLC6A13 CPLX1 SYT1 SLC6A11 DNAJC5 STX1A SLC6A1 VAMP2 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants FLT3 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex NCOR1 TBL1XR1 HDAC3 GPS2 NCOR2 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters SLC4A7 SLC4A10 SLC4A8 SLC4A9 SLC4A2 SLC4A3 SLC4A1 SLC4A5 AHCYL2 SLC4A4 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta TAX1BP1 NLRX1 IKBKB NLRC5 IFNB1-4 AGER IKBKG S100A12 MAP3K1 CHUK APP TANK TRAF3 IKBKE UBA52 UBE2D1 DHX58 RNF125 RNF216 UBE2D3-1 ATG12-1 RELA ATG5 RPS27A UBB;UBC ISG15 NFKB1 NFKBIA NFKB2 IRF7 NFKBIB TKFC TNFAIP3 TOMM70 HSP90AA1 CYLD HSP90AB1 TBK1 IRF3 CASP8 UBA7 DDX58 IFIH1 PIN1 RNF135 SIKE1 PCBP2 MAVS TRIM25 TRAF2 OTUD5 HMGB1-1 RIPK1 CASP10 FADD EP300 UBE2K UBE2L6 ITCH HERC5 SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 CREBBP UBE2D3;UBE2D2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation MAPK1 RAC1 VAV2 HRAS MAPK9 MAPK3 MAPK8 SYK FOS VAV1 MAPK10 MAP3K1 PAK1 SOS1 JUN PAK2 PLCG1 MAP2K4 MAP2K7 GRAP2 LYN PLCG2 VAV3 LCP2 NRAS SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins UBE2I NUP107 NUP43 RANBP2 SUMO1 SUMO2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 TOPORS SEC13 NUP133 PIAS4 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress ATF4 CCL13;CCL2 CEBPB NFYA-1 DDIT3 CEBPG ASNS IGFBP1 ATF3 DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 DCP2-1 ATF6 CXCL8 HERPUD1 NFYB NFYC TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 KPNA1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 KPNB1 SEC13 NUP133 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) CNOT2 CNOT3 HIRA CNOT8 BTG4 CNOT9 ZFP36L2 TEAD4 H2AJ EIF4E EIF4B EIF4G1 H2BC5 H2BC1 TUT7 TUT4 LEUTX DPPA4 DPPA2 TPRX1;RAX2 TNKS1BP1 ZSCAN4 H2AC4 DUX4;DUXA DUXB DICER1 PAIP1 TP53 H2BC21 H2AZ2;H2AZ1 KDM5A STPG4 UHRF1 AICDA METTL23 PABPC1;PABPC3 DPPA3 TET3 KDM6A H2AC14 YAP1-1 PABPN1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CNOT10 SRPK1 CNOT11 KDM5B NPM2 H1-8 H2BC15;H2BC3;H2BC11;H2BC12 DIS3L2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EP300 H2AC20 EIF4A2 AGO2 EIF4A1 CNOT6L H2AB2;H2AB3;H2AB1 CNOT4 KDM6B CNOT6 CREBBP EIF4A3 CNOT7 CNOT1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling TNFAIP3 TAX1BP1 CYLD NLRX1 NLRC5 TBK1 IRF3 UBA7 DDX58 IFIH1 PIN1 RNF135 PCBP2 TRAF3 MAVS TRIM25 IKBKE UBA52 UBE2D1 RNF125 RNF216 UBE2D3-1 ATG12-1 ATG5 OTUD5 RPS27A UBB;UBC ISG15 UBE2K UBE2L6 ITCH HERC5 UBE2D3;UBE2D2 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases CASP1 ATM PIDD1 CASP6 TP53 CASP2 TP63 TP73 APAF1 NLRC4 CASP10 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT3 CCT4 CCT2 CCT6B CCT6A ACTB-1 TCP1 CCT8 CCT7 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism NCBP2-1 NUP43 RANBP2 NUP37 GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 SMN2;SMN1 CLNS1A GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX20 SNRPE-2 SNRPG-2 SNUPN NUP107 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 TGS1 SEC13 NUP133 NCBP1 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions MED7 MED20 MED9 MAP1B BECN1 JAK1 TLR4 CDK19 IFNB1-4 MED28-1 GPC1 GPC3 CD14 UBA52 GPC2 GPC5 GPC4 TLR7 GPC6 TLR3 AGRN RPS27A UBB;UBC EIF2AK2 ISG15 RBX1 MED19 MED18 MED11 MED29 MED22 MED31-1 MED21 TYK2 MED30 IFNAR1 TLR6 TLR2 STAT2 IRF3 CUL5 DDX58 CCNC-1 IFIH1 HSPG2 CLEC4M;CD209-2 MAVS TRIM25 MED13L CX3CR1 SDC4 SDC2 SDC3 ARIH1 BCAP31 H2BC15;H2BC3;H2BC11;H2BC12 MED16 MED15 LY96 MED17 MED12 MED14 ELOC-1 MED13 SDC1 MED10 ELOB EP300 UBE2L6 HERC5 MED27 MED1 MED26 CDK8 MED23 CREBBP MED8 MED25 MED4 MED6 MED24 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L NCBP2-1 GTF2F1 HNRNPM HNRNPH1 GTF2F2 HNRNPF POLR2J;POLR2J2;POLR2J3 HNRNPA1-1 ESRP1 TIAL1 TIA1 RBFOX2 ESRP2 PTBP1 NCBP1 POLR2A POLR2B POLR2C POLR2D FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex SMARCE1 SMARCD3 SMARCA4 PHF10 BCL11B SMARCB1 ARID1A ACTB-1 SMARCC1 SMARCC2 BCL7A BCL7C BCL7B DPF2 BCL11A SS18 SMARCD1 SMARCD2 ACTL6A FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex SMARCA2 SMARCE1 SMARCA4 SMARCB1 ARID1A ARID1B ACTB-1 SMARCC1 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SMARCD1 SS18L1 ACTL6A RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination POLR2E POLR2F POLR1C POLR2H POLR1D POLR2L GTF2H1 TTF1 GTF2H3 UBTF GTF2H4 CDK7 POLR1A ERCC3 POLR1B ERCC2 POLR1E POLR1F MNAT1 POLR1G POLR1H TAF1D TAF1B TAF1C TAF1A CAVIN1 TBP GTF2H2C;GTF2H2C_2;GTF2H2 CCNH SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants MAP2K2;MAP2K1 JAK2 MAPK1 BRAP FGB HRAS CAMK2G FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B MAP3K11 VCL FN1 CALM3;CALM1 CSK MARK3 SRC KRAS CAMK2B CAMK2D ITGB3 CAMK2A ARAF PEBP1 ARRB1 YWHAB PHB IQGAP1 ARRB2 NRAS RAP1B RAP1A O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation MGAT5B-1 B3GNT3 ST6GALNAC2 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 ST6GALNAC4 CRPPA GALNT1 DAG1 GALNT12 SEMA5A POFUT2 POMT2 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 ADAMTS4 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL2 MUC12 MUC13 MUC15 THSD7A ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON RXYLT1 MUC3A POMGNT1 EMID1 MUC5AC ADAMTS20 B3GLCT CFP B4GAT1 THBS2 THBS1 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MMRN2 MUC1 ADAMTS14 MMRN1 MUC2 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 CHST10 GALNT3 MUC17 C1GALT1 MUC5B MUC20 MUC21 B3GNT7 GALNT11 B3GNT4 GALNT14 GALNT13 B3GNT2 GALNT16 GALNT15 GALNT18 B3GNTL1 GALNT10 GALNT9 SLC35A1 GALNT8 B3GNT9 B3GALNT2-2 B3GNT8 B3GNT6 B3GNT5 LARGE2 CHST4 GALNT9;GALNT17 GCNT1 GCNT3 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT GALNTL5 GALNTL6 FKTN SLC35A4 FKRP FUT10 FUT11 POMGNT2 POMK B4GALT6 B4GALT5 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS NTRK2 BDNF HRAS SOS1 NTF4 NRAS CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation IARS1 AIMP1 AIMP2 QARS1 EPRS1 SARS1 TARS1 AARS1 HARS1 RARS1 FARSA FARSB MARS1 YARS1 NARS1 CARS1 PPA1-1 VARS1 DARS1 GARS1 WARS1 LARS1 EEF1E1 KARS1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation ARSA ATG7 PRKCD ARHGAP9 CTSS CTSB HUWE1 CFD SLC11A1 FCER1G FCN2;FCN1 TNFRSF1B C5AR1 XRCC6 NME2 NRAS XRCC5 RAP1A STING1 MAPK1 SERPINA1 IMPDH1 A1BG IMPDH2 FAF2 CTSC MAPK14 SERPINA3 HSP90AB1 RHOF ROCK1 ORM2;ORM1 UBR4 QSOX1 AHSG ARHGAP45 ARG1 CD63 CD59 TRAPPC1 HBD;HBB CD177 MOSPD2 PECAM1 IQGAP1 CLEC4D RAP1B GDI2 HGSNAT CAB39 PPIA VCL LAMTOR2 LTA4H LAMTOR1 RAB31 LAMTOR3 SNAP25 STK10 TCIRG1 FRMPD3 RAB18 GMFG ABCA13 FTH1 CAPN1 ALDH3B2;ALDH3B1 PGLYRP1 NHLRC3 MCEMP1 SCAMP1 UNC13D RNASE3;RNASE2-2 PADI2 SLC44A2 STOM SERPINB3;SERPINB4-1 CRACR2A DBNL PRDX4 S100A11 JUP PA2G4 ATP6V0C PIGR SERPINB1 NFAM1 CHRNB4 TMC6 PLEKHO2 DIAPH1 CAND1 SERPINB10 SERPINB12 GRN AGA ERP44 LRG1 ATP6V1D HMOX2 YPEL5 ADGRE5 GHDC ADGRE3 TMEM179B EPX ATP6V0A1 LAMP1 TOM1 FTL-1 KCMF1 OLFM4 ARL8A BRI3 PTPRB LCN2 NIT2 GM2A ACP3 RNASET2 TMBIM1 SNAP23 CANT1 FGL2 PRCP CPPED1 VPS35L C6orf120 KRT1 METTL7A-1 SLPI CRISPLD2 ACAA1-1 TMEM63A BST2 ALAD SYNGR1 VAT1 CYBB SLC27A2 PTPRN2 DSC1 STK11IP CYBA PRG2 NBEAL2 BIN2 PRG3 S100A7A;S100A7 PTPRJ GLIPR1 CAMP CD55 CD53 RAP2B DNASE1L1 ACTR10 NCKAP1L CSTB PAFAH1B2 C1orf35 PGRMC1 PPIE SDCBP HMGB1-1 ATAD3A;ATAD3B CREG1 ORMDL3 GCA PTGES2 ELANE SVIP GSDMD QPCT CD68 MPO DYNLT1 COTL1 ENPP4 MMP9 OSTF1 CD93 IRAG2 DOK3 PTPRC ADGRG3 DPP7 GGH DNAJC13 TARM1 DEGS1 MS4A3 SLC2A5 TNFAIP6 CRISP3 HEBP2 PSEN1 CHI3L1 CLEC12A NCSTN MVP TMEM30A CMTM6 PDAP1 S100P PTX3 GLA AP2A2 VAPA TYROBP HEXB DDX3X-1 CLEC5A NPC2 GLB1 PYCARD C3AR1 GUSB ARSB FUCA1 FCGR3A;FCGR3B ARPC5 IDH1 CTSG ACTR2 FGR TLR2 DYNC1LI1 BST1 LTF DSN1 GNS FRK DERA PYGB MIF PYGL CNN2 GSN MANBA PGAM1 GAA CYB5R3 HVCN1 ALDOC ALDOA RAB3D CD44 DYNC1H1 AGL-1 RAB44 RAB37 RAB4B EEF1A1 CD36 EEF2 ADAM10 GYG1 RAB24 DSP DSG1 PKP1 MLEC P2RX1 ALOX5 PRDX6 C3-1 COPB1 MAN2B1 HPSE MGAM B4GALT1 PLAC8 CHIT1 PLAUR GSTP1 HK3 PGM2 CD33-1 CSNK2B PGM1 CPNE3 RAB10 RAB14 RAB27A MAGT1 ATP8A1 RAC1 GALNS ATP11B PFKL ATP11A SNAP29 S100A12 AOC1 TICAM2 ADA2 CD14 ATP8B4 PKM HP;HPR VCP-1 GOLGA7-1 ANO6 AMPD3 ITGAM ITGB2 SURF4 APRT PNP-1 ITGAX CD47 ILF2 DDOST APEH LPCAT1 AGPAT2 PTPN6 IST1 TBC1D10C CEP290 TCN1 ACLY ASAH1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 NAPRT PDXK CR1L;CR1 LAMP2 CCT2 FUCA2 PLAU COMMD9 SERPINB6-2 COMMD3 CCT8 FPR1 S100A9 S100A8 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CXCL2;CXCL3;CXCL1-1 RHOA RAB5B ITGAL CYFIP1 RAB5C MMP25 RAB6A APAF1 PSAP STBD1 IGF2R RHOG RAB9B ADAM8 DOCK2 ACTR1B CTSH HSPA1A;HSPA1B RAB7A MMP8 PLD1 IQGAP2 PPBP ARMC8 LGALS3 KCNAB2 SIRPA;SIRPB1;SIRPG SELL OLR1 LYZ-1 CXCR1 CST3 CXCR2 DGAT1 TTR KPNB1 FABP5 TSPAN14 DEFA6;DEFA4;DEFA5 PRSS3;PRSS2;PRSS1 SIRPB1 ANPEP LAIR1;LAIR2-1 MME ITGAV SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 ANXA2 ATP6AP2 OSCAR CTSD HSP90AA1 DNAJC3-1 GPR84 SIGLEC5;SIGLEC14 BPI SPTAN1 CAP1 CAT TIMP2 RETN CFP VNN1 SLC15A4 NFASC NDUFC2;NDUFC2-KCTD14 NEU1 MGST1 PSMD6 PSMD7 PSMD2 PSMD3 CTSA PSMD1 CDK13 PSMC2-1 PSMA5 GPI FPR2 PSMD12 PSMD11 PSMD14 PSMD13 CDA PSMB7 CTSZ RAB3A PSMB1 NFKB1 TXNDC5 TRPM2 PSMA2-1 HSPA6 HSPA8 VAMP8 PSMC3 DNAJC5 PTAFR SRP14 B2M AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CKAP4 TOLLIP SLCO4C1 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n RFT1 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNC2LI1 KIF3B KIF3A TTC21B WDR35 KIF3C IFT43 IFT46 IFT122 IFT20 IFT22 DYNLT2B IFT74 IFT27 DYNLRB2 DYNLRB1 TTC26 WDR19 HSPB11 DYNC2I2 IFT52 DYNC2I1 TRAF3IP1 IFT172 TRIP11 KIFAP3 CLUAP1 IFT57 DYNC2H1 TNPO1 KIF17 IFT80 DYNLT5 IFT88 IFT81 TTC30A;TTC30B DYNLT2 IFT140 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME ABCC2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 NAT1 GGT7 ABCC1 GGT6 SULT2A1-4 GGT1 ABCC3 ACY1;ABHD14A-ACY1 ABCG2 GSTT1 GSTP1 CNDP2 ABCC4 GGT5 ABCC5 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2E1 UGT1A1;UGT1A6 GSTM1;GSTM2-1 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) SC5D DHCR7 EBP DHCR24 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MTFMT MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MTIF2 MRPL47 MTIF3 MRPL48 MRPS7 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS36 MRPS33 MRPL18 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 LOC107987373;MRPL23 MRPL30 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins ACOX1 AGPS SCP2 PHYH-4 ACAA1-1 HSD17B4 TYSND1 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis B4GALT1 SLC2A1 LALBA REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells MAMLD1 HNF1B SNW1 NEUROG3 KAT2B KAT2A NOTCH1 MAML2 HES1 MAML1 EP300 CREBBP ONECUT1 RBPJ PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB ADCY4 PRKACA-1 ADCY9 PRKAR2A PRKACB-1 PRKAR1B ADCY3 NBEA PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 ADCY7 ADCY6 PRKAR1A PRKAR2B ADCY5 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants ALK GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis CLINT1 AP3B1 CPD VAMP2 SH3D19 TPD52 TFRC AP3S2;AP3S1 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SNX5 ARF1 FTH1 TBC1D8B SNAPIN SORT1 AP4E1 DTNBP1 PUM1 TPD52L1 BLOC1S1 GOLGB1 YIPF6 ACBD3 TXNDC5 HSPA8 AP4B1 DNM2 VAMP8 SH3GL2 VAMP7 DNAJC6 FTL-1 NAPA AP1G1 TGOLN2 SNX9 AP1S2 AP1B1 AP1S1 AP1S3 OCRL AP1M2 RAB5C AP1M1 PICALM PIK3C2A GAK IGF2R HIP1R NECAP1 ARRB1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption SLC2A2 SLC2A5 RSC1A1 SLC5A1-1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane SLC36A1 SLC38A1 SLC6A19 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC43A2 SLC43A1 SLC3A1 SLC3A2 SLC1A4 SLC7A11 SLC1A5 SLC7A10 SLC6A20 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP1BB GP5 F9 F10 F11 GP1BA F8 GGCX GP9 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere ITGB3BP CENPA H2BC21 CENPC HJURP RSF1 H2AZ2;H2AZ1 MIS18BP1 OIP5 CENPW KNL1 H2AJ CENPT CENPX MIS18A NPM1-2 CENPU H2AC14 CENPH CENPN-2 CENPS-CORT;CORT;CENPS CENPI RBBP4 SMARCA5 CENPK CENPL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPM H2BC5 CENPO RBBP7 CENPP CENPQ H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 RUVBL1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus RB1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P RPIA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TAB2 TAB1 TLR4 LY96 IRAK2 RPS27A UBB;UBC MAP3K7 TICAM2 TICAM1 TRAF6 CD14 UBA52 TAB3 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis HSP90AA1 TRADD CASP8 FLOT1 TNFSF10 FLOT2 PDCD6IP FASLG RIPK3 TRAF2 UBA52 PELI1 CDC37 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 RPS27A OGT-1 UBB;UBC MLKL FADD ITCH FAS STUB1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing HNRNPU RBM7 DDX41 DHX9 TCERG1 SNRPC SNRPA PPP1R8;STX12 HTATSF1 RBM25 SNRNP70 PRPF40A SRSF10 SRSF12 TRA2B RBM39 YBX1 HNRNPC RBMX NCBP1 ACIN1 NCBP2-1 PPIL2 PQBP1 ZNF830 SRRT SNRNP200 FUS BCAS2 CTNNBL1 PRCC HNRNPA3 GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 DHX16 HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD GPATCH1 PNN HNRNPA1-1 CXorf56-1 SF3B4 SF1 SF3B5 DHX8 PRKRIP1 SF3B2 CWF19L2 SF3B3 WDR70 ISY1;ISY1-RAB43 DHX35 SF3B6 PRPF38A SF3B1 SMU1 SF3A3 NKAP UBL5 SF3A1 GCFC2 SF3A2 PRPF18 XAB2 SDE2 PHF5A FAM32A CACTIN PRPF31 RBMX2 TXNL4A SNIP1 SNRPN SNW1 IK PRPF4B CHERP LENG1 LSM5 PRPF4 LSM4 PRPF3 SNRNP27 LSM3 ZMAT2 LSM2 CCDC12 YJU2 LSM8 LSM7 LSM6 NSRP1-1 PTBP1 PPWD1 USP39 PLRG1 SART1 TFIP11 SNRPA1 SYF2 DNAJC8 LUC7L3 C9orf78 PUF60 WBP4 SNRPB2 RNF113A MFAP1 SNRNP40 RBM42 BUD13 FAM50A PPIL3 PPIL4 SRRM2 DDX5 AQR CRNKL1 PRPF19 HNRNPH1 HNRNPH2 SAP18 CWC25 PPIL1-1 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 U2AF1L5;U2AF1 EIF4A3 CASC3 CDC40 SRRM1 DDX39B SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A SRSF1 U2AF2 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 ALYREF UPF3B RNPS1 SNRPD2 SNRPD1 SNRPD3 HSPA8 SNRPF POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 MTREX SNU13 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins PRSS21 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L PRSS41 TECTB PLET1 CPM PSCA RTN4RL2 PGAP1 RTN4RL1 LYPD1 LYPD2 MELTF LYPD3 MSLN THY1 LYPD4 LYPD5 LYPD8 LYPD6B PIGS PIGU PIGT GPIHBP1 PIGO FCGR3A;FCGR3B FOLR2 PIGN PIGP PIGZ PIGW PIGV OTOA PIGC CD109 PIGB PIGA PIGK IZUMO1R PIGM NRN1L PIGL PIGG LY6G6C PIGF LSAMP PIGH NTM LY6K LY6D PIGX-1 LY6H SPRN SPACA4 ALPG;ALPP;ALPI-1 MDGA2 MDGA1 PLAUR RECK NRN1 ART3 ART4 OPCML NTNG1 NTNG2 BST1 GPAA1 NEGR1 XPNPEP2 TECTA;TBCEL-TECTA LY6E PRND CNTN5 VNN1 ALPL VNN2 CNTN3 CNTN4 TEX101 DPM1 DPM2 GPLD1 DPM3 GP2 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function BRAF PPP1CC MRAS ARAF SHOC2 RAF1 YWHAB PPP1CB NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus YBX1 PSENEN PSEN2 JAG2 WWP2 PSEN1 NOTCH3 JAG1 APH1A ADAM10 EGFR NCSTN DLL1 APH1B MIB1 DLL4 NEURL1B NEURL1 RPS27A UBB;UBC TACC3 EGF UBA52 MIB2 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOX3 PHYH-4 SLC25A17 HACL1 NUDT7 AMACR PECR ACBD5-1 CRAT CROT ACOXL ACOT8 NUDT19 EHHADH-1 ACAA1-1 HSD17B4 ACBD4 DECR2 ABCD1 SLC27A2 ACOT4 ACOX2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME ABCB1 HSD11B1 ALB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD11B2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SERPINA6 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle BUB1B-PAK6;PAK6 WASL ARHGEF7 PAK4 MAP3K11 USP9X WDR6 RHOV PARD6A PAK1 VANGL1 CDC42 DST NCK2 PAK2 GIT1 NCK1 SH3RF1 SPTAN1 ARHGAP12 DLG5 TXNL1 PARD6B PIK3R1 GIT2 CCP110 CEP97 PEAK1 MYO9A DEPDC1B ZNF512B SPTBN1 IQGAP1 TPM4 EPHA2 CLTC TPM3 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs POLR2E POLR2F POLR2G H2BC21 POLR2H POLR2I POLR2L H2AZ2;H2AZ1 H2AJ POLR2J;POLR2J2;POLR2J3 AGO3;AGO1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 RAN TNRC6A-1 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 IPO8 POLR2A POLR2B POLR2C POLR2D CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants ALK NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions CASK PIK3CB ACTN3 PIK3R2 WASL PIK3R1 CD2AP ACTN2 PIK3CA KIRREL3 KIRREL1 KIRREL2 MAGI2 NPHS1 NCK2 ACTN4 SPTBN1 NCK1 FYN SPTAN1 IQGAP1 ACTN1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism CHDH SARDH ALDH7A1 BHMT SLC44A1 SLC22A4 DMGDH SLC44A2 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell DISP2 SCUBE2 DHH IHH ADAM17 GPC5 SHH NOTUM FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits RPL34 EIF3F RPL10A EIF3D RPL8 EIF3A RPL9 EIF3B RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 EIF3C;EIF3CL EIF1AY;EIF1AX EIF3M RPL4 EIF3K RPL30 EIF3L RPL3 EIF3I EIF3J RPL32 EIF3G EIF3H RPL31 EIF3E APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway NEIL2 PNKP NEIL1 POLB OGG1 XRCC1 LIG3 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG DGAT2 DGAT1 PNPLA3 PNPLA2 DGAT2L6 MGLL AWAT2 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles FMO2 FMO3 FMO1 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex IRAK1 CHUK PELI3 IKBKB TRAF6 PELI2 UBE2V1 UBE2N IKBKG PELI1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling WWP1 ITCH UBA52 SRC NEDD4 RPS27A UBB;UBC SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants FLT3 PTPN11 HRAS PIK3R1 PIK3CA CDKN1A STAT5A STAT5B SOS1 PIM1 NOX4 GRB2 GAB2 NRAS BCL2L1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine TERF2IP H2BC21 H2AZ2;H2AZ1 H2AJ TERF1-1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 NTHL1 TDG MBD4 H2BC1 SMUG1 NEIL3 NEIL2 NEIL1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 TERF2 POT1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism DEGS1 SMPD3 SMPD2 STS ARSA GLA SUMF2 SUMF1 VAPA VAPB HEXB ARSL HEXA GLB1L3 ARSJ GLB1L2 ARSK ST3GAL2 ARSH ST3GAL3 ARSI GLB1L GLB1 ARSG ARSB ARSD-1 CERK GBA2 OSBP MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 UGCG UGT8 SGPL1 B4GALNT1 KDSR B3GALNT1 ACER2 ACER1 FA2H ACER3 DEGS2 GAL3ST1 SMPD4 SPTLC1 SPTLC3 A4GALT CERS3 CERS4 CERS5 CERS6 SPHK2 CERS1 CERS2 SMPD1 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB ORMDL1 SGPP2 SGPP1 GALC ST6GALNAC5 NEU2 ASAH1 NEU3 NEU1 ST3GAL5 ST8SIA5 CTSA B3GNT5 ALDH3B2;ALDH3B1 SPHK1 M6PR ABCG2 GBA FUT2 FUT1 B3GALT4 GM2A CSNK1G2 ABCC1 B4GALT6 PSAP ORMDL3 B4GALT5 ST6GALNAC6 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC MUC5B MUC20 MUC21 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC12 MUC6 GALNT3 MUC13 MUC17 MUC15 METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids HSD17B1 STS LBR IDI2 MSMO1 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 LDLRAP1 PLPP6 CUBN CYP8B1 STARD3 STARD4 STARD6 STARD3NL STAR LGMN TSPO POMC KPNB1 FABP6 SREBF1 CGA HSD11B1 ALB HSD11B2 SERPINA6 OSBP AKR1B15;AKR1B10 CYP24A1 HSD3B1;HSD3B2 RAN CYP21A2 CYP11B1;CYP11B2 GC SMARCD3 CHD9 HSD17B3 HELZ2 HSD17B12 SRD5A2 STARD5 SRD5A1 LRP2 SLC10A1 CYP17A1 SLC10A2 TGS1 SLC51A FASN SLC51B AKR1B1 CH25H SLC27A5 OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 NCOA1 MED1 HSD17B11 NCOA2 HSD17B2 CREBBP NCOA6 CYP19A1 TBL1XR1 CARM1 SRD5A3 BAAT ACOX2 TM7SF2 HMGCS1-1 GGPS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK SAR1B INSIG2 INSIG1 CYP2R1 ACACB AMACR ACACA PMVK SC5D SCAP FDFT1 FDPS MBTPS1 SEC24B SEC24A NFYB TSPOAP1 NFYC CYP51A1 SEC24D-1 PIAS4 SQLE GPAM SP1 UBE2I SCD NFYA-1 VDR DHCR7 SEC24C CYP27A1 MBTPS2 HSD3B7 AKR1D1 NR1H4 CYP7B1 CYP7A1 RXRA ABCC3 SUMO2 FDX1 FDXR PPARA ACOT8 HSD17B4 SLC27A2 CYP46A1 CYP39A1 CYP27B1 CYP11A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO1A2 ABCB11 OSBPL1A LHB INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling TAB2 TAB1 LRRC14 USP14 PTPN4 NLRX1 PELI3 PELI2 NLRC5 NOD1 MAP3K3 NOD2 IL33 AGER IRAK2 S100A12 N4BP1 TNIP2 IL36RN USP18;USP41 IL1RL1 IL1RL2 STAT3 MAP3K8 IL1RN IL1R2 NFKB2 TIFA ALPK1 IL1R1 MAP2K2;MAP2K1 CTSG PTPN12 IRAK1 SMAD2;SMAD3 MAP2K4 PTPN11 MAP2K6 PTPN6 MAPK8 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMC2-1 PTPN18 APP PSMA5 IL37 PTPN20 PSMA6 PTPN23 PSMA3 PSMA4 PTPN13 PSMA1 PTPN14 UBA52 IL18BP SIGIRR PSMD12 PTPN9 PSMD11 PTPN7 PSMD14 PTPN5 PSMD13 PTPN2 CUL1 IL18R1 SQSTM1 RELA IRAK3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 RBX1 PSMA2-1 TP53 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NFKBIB IL4 IL18RAP IL13 ALOX5 IL1RAPL1 TBK1 CASP8 CASP1 IL18 TRAF2 IL1A IL1B PELI1 HMGB1-1 RIPK2 TOLLIP MYD88 GSDMD SAA2;SAA1 NKIRAS1 TRAF6 IL36A NKIRAS2 IL36B UBE2V1 IKBIP IL36G IL1F10 UBE2N IRAK4 TAB3 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ PRKCZ MAPK1 HRAS PDPK1 NRAS REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity TJP1 GJA1 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud GREM1 EYA1 BMP4 GDNF ITGA8 FOXC2 FOXC1 SIX1 SLIT2 HOXD11 HOXC11 HOXA11 ROBO2 SALL1 SIX2 RET GFRA1 ITGB1 NPNT WNT11 PAX2 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity A2M F12 C1QBP PLAUR KLKB1 KRT1 SERPING1 KNG1 HRG REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors PHF20 POU4F1 POU4F2 ZNF385A TP73 TP53 TP53BP2 BANP AKT2 TP63 AKT3 AKT1 PPP1R13B PPP1R13L GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation GJB3 GJB6 GJB5 GJB7 GJD4 GJD3 GJA1 GJB2 CLTCL1 AP2M1 MYO6 DAB2 DNM1 GJB1 CLTB TJP1 GJD2 GJC1 DNM2 GJA10 GJA3 GJA5 GJA4 GJA9 GJA8 CLTC GJC2 CLTA GJB4 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK RAC1 ARHGEF26 KALRN MAPK8 VAV1 MCF2 BAD TIAM1 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 BCL2L11 NGFR ARHGEF12 ARHGEF17 ARHGEF3 ARHGEF1 ARHGEF2 ECT2 RASGRF2 MAGED1 NET1 VAV3 ARHGEF40 PLEKHG2 ARHGEF15 VAV2 PLEKHG5 ARHGEF19 TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 NGF FGD1 FGD2 ARHGEF18 FGD3 GNA13 FGD4 ARHGEF33 ARHGEF37 SOS1 ARHGEF39 ARHGEF38 SOS2 TRIO ITSN1 ABR PREX1 MCF2L ARHGEF16 AATF ARHGEF5 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC MMACHC GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking GJB3 GJB6 GJB5 GJB7 GJD4 GJD3 GJA1 GJB2 CLTCL1 AP2M1 MYO6 DAB2 DNM1 GJB1 CLTB GJD2 GJC1 DNM2 GJA10 GJA3 GJA5 GJA4 GJA9 GJA8 CLTC GJC2 CLTA GJB4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 NCBP2-1 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 EIF4G1 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A GSPT2 RPL13A-1 GSPT1 RPL11 RPS27L RPS15A RPL14 RPS3 PABPC1;PABPC3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ETF1 RPS27 NCBP1 RPL4 RPL30 RPL3 UPF1 RPL32 RPL31 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases GSDMD CASP3 CALM3;CALM1 CASP5;CASP4 SERPINB1 IL18 IL1B SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR NCBP2-1 SPRED2 SPRED1 HNRNPM FLRT2 HNRNPF FLRT1 HNRNPA1-1 FGFRL1 GAB1 FRS3 PLCG1 UBA52 ESRP1 TIAL1 TIA1 RBFOX2 ESRP2 PTBP1 RPS27A UBB;UBC CBL POLR2A POLR2B NRAS POLR2C POLR2D POLR2E POLR2F MAPK1 POLR2G HRAS POLR2H POLR2I MAPK3 POLR2L FGFBP1 BRAF FGFBP3 FRS2 KLB GTF2F1 HNRNPH1 PPP2R1A GTF2F2 PIK3CA FLRT3 FGF1 POLR2J;POLR2J2;POLR2J3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 SOS1 FGF20 FGF23 FGF22 FGF16 FGF19 FGF18 MKNK1 FGFR4 SPRY2 FGF10 PTPN11 PIK3R1 PPP2CB;PPP2CA TGFBR3 ANOS1-1 GIPC1 NCBP1 GALNT3 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 PROC PROS1 F5 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation AP2A2 AP2M1 AP2B1 ATP6V1H CD8B;CD8B2 AP2S1 AP2A1 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DIAPH1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex PDK2 GSTZ1 DLD PDK1 PDHX PDHA1 SIRT4 PDP1 PDP2 PDHB PDPR PDK4 PDK3 DLAT CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway CAMKK2 CAMK2G PRKCA ADCY4 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 PDE1C ADCY7 KPNA2 PDE1B PDE1A ADCY6 PRKAR1A GRK2 ADCY5 PRKCD PRKCG PRKACA-1 ADCY9 PRKACB-1 PRKAR1B NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A CAMKK1 SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants HRAS NRAS KRAS SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNB1 PAX6 GNB3 GPR119 DPP4 GNAT3 CDX2 LEP SPCS3 SPCS2 SPCS1 FFAR4 CTNNB1 PCSK1 FFAR1 SEC11A SEC11C GCG GNG13 TCF7L2 GRP SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease JAK2 PIK3R3 HRAS PIK3R2 PIK3R1 LYN PIK3CA YES1 LCK STAT5A STAT5B SOS1 FYN STAT1 KIT STAT3 NRAS SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOU YWHAH LBR PTK2B PRKCD YWHAZ WDR91 ANKFY1 PLK1 WDR81 SH3RF1 CDC42SE2 ARHGAP9 OSBPL11 LRRC41 LRRC1 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 KCTD3-1 FGD5 CHN2 CHN1 FARP1 DEF6 WDR11 SRC CAV1 SHKBP1 FILIP1 STAM GOPC UHRF1BP1L CDH1 FAM13B HGS FAM13A CTNNB1 RALGAPA1 STAM2 TEX2 FAM91A1 ARMCX3 DDRGK1 NSFL1C ZNF512B VAV3 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 YWHAB PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 SH3BP1 MAPK1 WHAMM VAV2 GOLGA3 BAIAP2L2 STEAP3 MAPK3 SPATA13 KIDINS220 TMEM87A FAF2 FRS2 AKAP12 HINT2 MAPK14 ITSN2 SH3PXD2A CCDC115 RALBP1-1 RHOH HSP90AB1 RHOF MAPK11 ROCK1 RHOD ROCK2 RHOV GPS1 ACBD5-1 TWF1 EMC3 RAPGEF1 MSI2 PRAG1 RHOBTB1 SOS1 ARHGAP44 RHOBTB2 SYDE2 ACTG1 DOCK11 BASP1 TRA2B STK38 ARHGAP45 MYO6 ARHGAP19 RBBP6 ARHGAP18 TOR1AIP1 SPEN RNF20 ARHGAP12 SCFD1 ARHGAP22 CPSF7 ACTN1 ARHGAP20 TMOD3 ARHGAP29 TXNL1 MACO1 COPS4 ARHGAP28 CDC37 ARHGAP27 PICALM CFL1 COPS2 ARHGAP25 ARHGAP24 PDE5A PHIP ARHGAP23 HNRNPC ARHGAP33 ARHGAP31 VIM DIAPH2 RBMX DBN1 DNMBP ARHGAP30 DOCK6 CTTN DOCK9 RND2 PGRMC2 ARAP1 XPO1 ALS2 PEAK1 CCDC187 MOSPD2 ARHGAP11A-1 ADD3 FAM169A FMNL1 FMNL2 TRIP10 NCOA2 IQGAP1 GRB7 KIF14 STMN2 MAP3K11 RND1 STIP1 KDM4C-1 KLK3;KLK2 LAMTOR1 WDR6 PLXNA1 CALM3;CALM1 FAM83B ANKRD26;CCDC144A;LOC105375816 DST YWHAE RRAS2 ALDH3A2 TMEM59 CCDC88A FAM135A CDC25C ACTC1;ACTG2 VHL VANGL2 RTKN UBXN11 SOWAHC CPD ARHGEF10L AKAP13 DLG5 LMNB1 STK10 PKP4 SLK ARHGEF11 TFRC ARHGEF10 ARHGEF12 STARD8 ARHGEF17 CIT RHOB DAAM1 ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 PKN3 ARHGEF28 IQGAP3 ATP6AP1 STOM RHPN2 ECT2 STARD13 JUP CAVIN1 PCDH7 MYO9A NET1 ANLN DIAPH1 DLC1 PKN2 PKN1 HMOX2 ARHGEF40 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 RHOC TIAM2 ARHGEF4 ARHGEF7 DLG4 NGEF ARHGEF6 FGD1 NCKAP1 FGD2 WASF1-1 FGD3 NCF1 GNA13 FGD4 NCF2 SNAP23 NCF4 ARHGAP6 FLOT1 DOCK10 SYDE1 ARHGEF39 FLOT2 ARHGAP42 PLXNB1 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 ARAP3 CYBB OCRL CYBA BCR AMIGO2 NOXO1 DBT BCAP31 ARHGAP17 ARHGAP15 ABR RACGAP1 SLITRK3 NHS SLITRK5 NCKAP1L WASF2 GIT2 BAIAP2 ARHGAP26 ABI2 TAOK3 ABI1 NOXA1 NOX3 NOX1 FERMT2 C1QBP SAMM50 CUL3 RASAL2 MTX1 LIMK2 LIMK1 MYH14 CYFIP2 MYH10 WIPF1 WIPF2 WIPF3 CTNNA1 RHOT1 CDKN1B BTK PLXND1 NCKIPSD DVL1 DVL2 DVL3 ARPC4 ARPC5 CCNE1 ARPC2 ARPC3 ERCC6L ACTR3-1 NUP107 ARPC1B ARPC1A ZWILCH WASL BUB1B PMF1;PMF1-BGLAP ACTR2 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 WAS SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 WASF3 NUP160 SKA1 SKA2 DSN1 PREX2 NUP85 RCC2 NDC80 WWP2 ZWINT KIF18A ARHGAP10 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC RAP1GDS1 MFN1 NUP133 MFN2 PPP2R5B MYO19 PPP2R5A TRAK2 PPP2R5D DOCK7 PPP2R5C RANGAP1 CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B MRTFA ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 SENP1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 DOCK3 CENPE CENPF CENPH FRS3 CENPI TAOK1 CENPK TIAM1 CENPL CPNE8 CENPM PTPN13 DOCK8 FNBP1L B9D2 FNBP1 CENPO SCRIB CENPP CENPQ NIPSNAP2 RHOJ SPC24 CDC42BPB SPC25 CDC42BPA MAD2L1 SLC4A7 NUP37 FMNL3 JAG1 LIN7B DSP RASGRF2 DSG1 DSG2 TJP2 H2AC14 PIK3R3 PIK3R2 PIK3R1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 SLC1A5 H2AB2;H2AB3;H2AB1 RAC1 PPP1R14A PPP1R12A FARP2 PPP1R12B VAV1 H2AJ ARHGAP39 SRGAP3 SRGAP2 SRGAP1 PAK1 PAK3 PAK2 H2BC5 H2BC1 VCP-1 PARD6B TRAK1 ABCD3 H2AC4 CCP110 CEP97 MYH9 H2BC21 YWHAG PRKCA PDPK1 H2AZ2;H2AZ1 PIK3CA LCK CDC42 SFN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PLD2 CSK H2BC15;H2BC3;H2BC11;H2BC12 DDX4 USP9X GJA1 UACA CFTR CCT2 CCT7 S100A9 S100A8 CCT6A ACTB-1 ARHGEF18 PRKCZ RHOBTB3 RHOA PARD6A PIN1 AAAS ARL13B ITGB1 CYFIP1 DOCK5 DOCK4 ANKLE2 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L STBD1 ARHGDIB EMD TMPO PLEKHG3 SRF RAB9A ARHGEF16 RHOG VRK2 KLC1 RAB9B LEMD3 KLC4 KLC3 ARFGAP3 DEPDC1B KLC2 NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 EPHA2 VAMP3 RAB7A GARRE1 ARHGEF26 SHMT2 PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 STX5 YKT6 PAK4 NDUFA5 MCAM MCF2 ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 PPP1CB FLNA PLIN3 MYL12B MYLK KIF5B MYH11 KIF5A KDM1A TPM4 CLTC TPM3 PTK2 BUB1B-PAK6;PAK6 MYL6 HSP90AA1 PFN1 ABL2 NCK2 NCK1 SPTAN1 CAPZB MUC13 EVL PFN2-1 SOS2 YWHAQ PAK5 MYO9B MTMR1 SPTBN1 SCAI SRRM1 DDX39B TAX1BP3 NF2 ROPN1;ROPN1B PRC1 PRKCB MTR-1 PIK3R4 AR MEN1 PIK3C3 TNFAIP1 RND3 CKB SEMA4F CKAP4 NISCH KCTD13 ABL1 ZAP70 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis HSD17B1 AKR1B15;AKR1B10 HSD17B11 HSD17B2 CYP19A1 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers H2AJ SF3B4 SF3B5 SF3B2 SF3B3 HDAC2 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 H2BC5 PHF5A PCK1 HDAC1 H2BC1 SNRPN CHERP MTA1 MTA3 H2AC4 SNRPA1 CTNNB1 PUF60 SNRPB2 CHD1 H2BC21 WDR5 H2AZ2;H2AZ1 CTCF RBBP4 CBX1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CHD4 CHD3 CBX3-1 H2BC15;H2BC3;H2BC11;H2BC12 CHD9 MTA2 CHD7 NR2C2 NKD2 FAM124B ZNF592 CHD5 IKZF1 EP300 IKZF2 IKZF3 SUPT16H PHF6 ZMYND8-1 ZNF827 ZNF687 TCF19 MBD2 NR2F2 CREBBP CDK2AP2 CHD2 CDK2AP1 ZNF532 SSRP1 MAFK NFE2L2 ADNP2 ADNP MBD3 GATAD2B GATAD2A AXIN2 IGF2 TCF12 SNRPD2 SNRPD1 SNRPD3 SNRPF SNRPB SNRPE-2 SNRPG-2 CTR9 UBE2I PWWP2B WDR61 MBD3L1 RTF1 PWWP2A CDC73 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 LEO1 DKK2 CHD6 SUMO1 G6PC1 H2AC14 PAF1 CHD8 NQO1 DHX15 MYOG MYOD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TCF4 FBP1 DDX46 DDX42 H2AC20 RBM17 H2AB2;H2AB3;H2AB1 SMNDC1 U2SURP LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 HAUS8 HAUS7 PCNT OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP250 CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CEP57 CETN2 CEP164 ACTR1A MAPRE1-1 CNTRL CEP290 CKAP5 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion PRKCA PLCB3 GNA14 PLCB1 PLCB2 GNA15 GNA11 GNAQ CHRM3 MARCKS NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN PSEN2 PSEN1 APH1A JAG1 NCSTN ADAM10 YWHAZ APH1B NOTCH4 DLL4 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type VCAN CHST14 CSPG5 CSPG4 NCAN BGN DCN BCAN RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle TXNL1 CCT2 CDC37 HSP90AA1 PHIP HNRNPC SRRM1 RBMX CCT6A DBN1 DDX39B HSP90AB1 CUL3 TWF1 MSI2 RHOBTB2 ACTG1 TRA2B STK38 MYO6 ACTN1 TMOD3 CCT7 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VCL PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 CTSS PSMD13 CTSB PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CTNNA1 PSMB2 PSMB3 SRC PSMB1 CTNND1 RPS27A UBB;UBC ADRM1 CDH1 PSMA2-1 SEM1 CTNNB1 JUP BANP PSMC5 DNM2 EPS15 PSMC6 CBLL1 PSMC3 PSMC4 PSMC1 MDM2-2 CTSV;CTSL MTBP RACK1 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CD4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage CDA HPRT1 TK2 GMPR2 ADK AMPD1 GMPR AMPD2 UPP1 AMPD3 DCK TYMP TK1 APRT ADAL DGUOK PNP-1 ADA UCKL1 UCK1 PUDP SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer SMAD2;SMAD3 TGFBR1-1 TGFBR2 TGFB1 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport PLEKHA8 CPTP CLN3 ESYT3 ARF1 ESYT2 ESYT1 GLTP DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria DCXR INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism MINPP1 PLCD1 MTMR7 NUP43 MIOX ISYNA1 INPP1 INPP5A RANBP2 IMPA1 IMPA2 CALM3;CALM1 IPPK NUDT11;NUDT10-1 PPIP5K1 PPIP5K2 PLCG1 NUDT4;NUDT4B IP6K1 NUDT3 IP6K3 NUP37 PLCG2 NUP107 PLCB3 IP6K2 PLCB1 PLCB2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR PTEN OCRL NUP88 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 INPPL1 PLD4 SEC13 INPP5B PLCZ1 NUP133 INPP5D INPP4A INPP5J PLCE1 ITPK1 INPP4B ITPKB ITPKC PLCB4 SYNJ1 ITPKA PLCH1 MTMR9 PLCH2 PLCD3 IPMK PLCD4 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC2A2 SLC6A3 SLC6A19 SLC36A2 SLC6A14 SLC12A3 NUP43 SLC2A9 SLC12A1 SLC12A6 SLC22A18 SLC7A7 SLC7A9 SLC35A1 RANBP2 SLC17A5 SLC34A2 SLC34A1 NUP37 SLC40A1 HEPH AVPR1B AVPR2 SLC5A7 AVP AVPR1A SLC11A2 SLC5A5 SLC26A2 GCK GCKR NUP107 CP SLC2A1 NUP205 NUP188 HK1 SLC9A6 AAAS SLC9A9 NUP42 NUP62 SLC4A4 NUP160 TPR BSG SLC39A4 NUP88 SLCO2A1 RAE1 SLC27A4 NDC1 NUP85 NUP214 NUP210 SLC5A2 NUP155 SLC33A1 NUP153 SLC6A5 NUP93 SLC26A4 NUP50 SLC17A8 SLC26A3 POM121;POM121C SLC6A2 SLC35A3 NUP35 RHAG SLC4A1 SLC22A12 NUP54 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC2A10 SLC1A1 SLC29A3 SLC3A1 SLC24A1 SLC24A4 SLC1A3 SLC20A2 SLC3A2 SEC13 SLC35A2 NUP133 SLC16A1 SLC24A5 SLC6A20 SLC35C1 SLC22A5 SLC5A1-1 TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE TLR3 TICAM1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation MTOR HSPA1L CRYAB CAMK2G HSP90AA1 MLST8 AKT1S1 PTGES3-1 DNAJB1 HSPA2 HSP90AB1 HSF1 HSPA8 EP300 CAMK2B CAMK2D CAMK2A RPTOR CREBBP HSPB8 HSPA1A;HSPA1B FKBP4 HSBP1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGFR PRDM4 HDAC3 HDAC2 NGF HDAC1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism ABCC2 GSTA3;GSTA1 HMOX2 ABCC1 FABP1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HMOX1 ALAS2 ALAS1 BLVRB ABCG2 FECH BLVRA COX15 UROS CPOX PPOX ALAD UROD ALB HMBS COX10 UGT1A1;UGT1A6 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism GNB1 SLC2A2 GNB4 GNB3 GNB5 KCNC2 KCNB1 KCNS3 AHCYL1 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 PRKAR2B INS;INS-IGF2 ITPR1 ITPR2 ITPR3 RAP1A KCNJ11 PRKCA PLCB3 PPP2R1B PLCB1 PPP2R1A PLCB2 ADCY4 PRKAR2A ADCY3 PRKAA2 ADCY2 ADCY1 ADCY8 ADCY7 AGPAT1 GNAI1 TALDO1 PRKAR1A ADCY6 GNAI2 RAPGEF3 ADCY5 RAPGEF4 CACNA1D AKAP5 PPP2CB;PPP2CA FASN ADIPOQ PPP2R5D ADIPOR1 ADIPOR2 ACSL4 ACSL3 STK11 IQGAP1 ACLY MARCKS SYT5 MLX TKT SNAP25 CACNA2D2 STX1A VAMP2 CD36 STXBP1 CACNB2 ACACB CACNB3 ACACA PFKFB1 GLP1R FFAR1 CACNA1A CACNA1E GNA14 GNA15 GNGT1 GNA11 ABCC8 ADRA2C GNAS-1 ADRA2A GNAQ CACNA1C SLC2A1 PRKAB2 GNG10 GNG2 GNG5 GNG4 GNG8 KCNG2 CHRM3 GCGR PRKAG2 GCG GNG13 GNB2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR8K3 OR8K1 OR4C11-1 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 OR2T2;OR2T35 OR6F1 OR51M1 OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 OR51A7 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 EBF1 OR6Q1 OR52I1;OR52I2-1 OR11H1;OR11H12 OR4F21;OR4F16;OR4F29;OR4F3 OR9G9;OR9G1 OR7C1;OR7C2-9 OR51G2 OR51G1 OR2H2 OR1F1 OR4L1 OR5B3-13 OR10Q1 OR6P1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2B11 OR2AP1 OR4A47-3 OR51F2 OR2G6 OR5M9 OR51F1 OR4K5 OR4K3 OR4K2 OR5M3 OR4K1 OR10P1 OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 OR11H4 OR4C13;OR4C46-2 OR2M4 OR6K3-1 OR4K17 OR1K1 OR1S1;OR1S2 OR4Q3 OR11H6 OR8G1;OR8G5 OR11G2 OR1J4 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR1I1 OR2K2 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR5B17-3 LHX2 OR10C1 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 LDB1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 OR5T1 OR6V1 OR10G6 OR6C4-1 OR10K1-1 OR52W1 OR5AS1 OR4F5;OR4F17;OR4F4 OR2T6 OR13C9 OR13C8 OR2T1 OR4X1 OR2L13 OR9A4 OR51T1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 OR2Y1 OR8D4 OR8D1 OR56B4 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR10A4 OR56A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 OR8B8 OR2W1 OR8B4 OR13F1 OR12D3 OR5AU1 OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 OR52A5-2 OR2V2 OR8A1 OR11A1 OR10G9;OR10G7 OR8I2 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR56B1-1 OR8B3;OR8B2-1 OR10W1 OR5B2 OR5D14 OR5D13 OR52M1 OR10V1 OR4C12 OR5A2 OR6C3 OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 OR4D11 OR2Z1 OR4D10 OR6A2 OR9G4 OR4E1 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5AP2 OR5B12 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 OR4C3 OR3A2 OR3A1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling PTPN11 MAPK1 MAPK3 BRAF FRS2 PPP2R1A PPP2CB;PPP2CA RPS27A FGF1 UBB;UBC CBL FGF2 FGF4 FGF9 FGF20 FGF23 FGF16 FGF18 UBA52 MKNK1 SPRY2 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 SMUG1 MPG OGG1 NTHL1 APEX1 TDG MBD4 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR MSH6 MSH2 MSH3 PMS2 MLH1 SEM1 MRE11 BRCA1 BRCA2 KAT5 OGG1 EXO1 NTHL1 NBN TOPBP1 NEIL3 NEIL1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters SLC22A11 SLC22A12 SLC22A6 SLC22A8 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling JAK1 IFNB1-4 USP18;USP41 UBA52 STAT1 IFIT5 IFI35 KPNB1 IFIT1 IFIT3 IFIT2 RPS27A UBB;UBC EIF2AK2 ISG15 RSAD2 IRF7 EGR1 MX1-1 RNASEL SOCS3 ABCE1 GBP2;GBP3;GBP1 TYK2 IFNAR1 IFITM3;IFITM2;IFITM1 IP6K2 IRF1 STAT2 IRF3 ISG20 ADAR OASL OAS1 IRF5 OAS3 IRF8 BST2 IRF6 SOCS1 IRF2 IRF9 SAMHD1 KPNA1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PTPN11 PTPN6 PSMB8 PTPN1 IRF4 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 NEIL1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium CYS1 NPHP3 UNC119B RP2 ARL3 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes PRSS3;PRSS2;PRSS1 CTRB1;CTRB2 CBLIF ABCD4 CUBN TCN1 AMN LMBRD1 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus POP5 POP7 POP1 TSEN15 NUP43 POP4 RTCB ZBTB8OS TSEN2 TSEN54 TSEN34 DDX1 RANBP2 C2orf49 RTRAF XPOT FAM98B RPP14 NUP37 TRNT1 CPSF4 NUP107 RPP30 CPSF1 NUP205 CSTF2 NUP188 AAAS CLP1 RPP38 NUP42 NUP62 NUP160 TPR RAN NUP88 RAE1 NDC1 NUP85 NUP214 RPP21 NUP210 RPP25 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 RPP40 SEC13 NUP133 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IRAK1 CHUK PELI3 IKBKB TRAF6 PELI2 UBE2V1 UBE2N IKBKG PELI1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 KLB FGF1 FGF2 FGF4 FGF6 FGF9 FGF20 FGF23 FGF16 PLCG1 FGF19 FGF18 FGFR4 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation TAB2 TAB1 MAP2K6 MAPK14 NOD1 NOD2 RIPK2 IRAK2 MAPK11 IKBKG MAP3K7 MAPKAPK3 IRAK1 MAPKAPK2 TRAF6 MAP2K3 UBE2V1 UBE2N TAB3 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling TAB2 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 TRAT1 PAK1 PAK3 PAK2 UBE2D1 GRAP2 PLCG2 HLA-DRA PIK3CB PDPK1 PIK3CA LCK WAS VASP HLA-DQB2;HLA-DQB1 NCK1 CSK ENAH EVL CD4 PAG1 INPP5D PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PTPN22 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PLCG1 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PTEN PTPRJ PIK3R2 PIK3R1 RIPK2 CDC34 HLA-DPB1-1 ITK TRAF6 PRKCQ FYB1 UBE2V1 CD3G ZAP70 PTPRC LCP2 LAT CD101 CD3E UBE2D3;UBE2D2 UBE2N CD3D DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency HLCS MCCC2 ACACA MCCC1 PC PCCA PCCB APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PTTG1;PTTG2 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CCNB1 CDC23 PSMD13 MAD2L1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 NEK2 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 BUB1B CDC20 CCNA2-1 CCNA1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism SMPD3 ASAH1 NEU2 SMPD2 NEU3 NEU1 STS ST3GAL5 ST8SIA5 ARSA CTSA GLA SUMF2 SUMF1 B3GNT5 HEXB HEXA ARSL GLB1L3 ARSJ GLB1L2 ARSK ST3GAL2 ARSH ST3GAL3 ARSI GLB1L GLB1 ARSG ARSB ARSD-1 M6PR GBA FUT2 FUT1 B3GALT4 CERK GBA2 ENPP7 GM2A UGCG UGT8 B4GALNT1 B3GALNT1 GAL3ST1 SMPD4 A4GALT SMPD1 B4GALT6 ASAH2 PSAP B4GALT5 ST6GALNAC6 GALC ST6GALNAC5 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells NCOR1 RNF2 TBL1XR1 FOS KLF13 MBD3 BATF IL4R SATB1 NFATC2 NFATC1 TPST2 HDAC5 TBX21 GATAD2B GATAD2A HDAC2 JUN HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 SMARCA4 SNW1 MTA1 YY1 MTA3 HDAC10 HDAC11 TNF RUNX3 NCOR2 KMT2A KAT2B KAT2A NOTCH1 POU2F2 STAT5A STAT5B MAF STAT6 DPY30 RBPJ HDAC4 IL4 POU2F1 MAMLD1 IL13 WDR5 GATA3 ETS1 MEN1 RBBP4 RBBP5 RBBP7 CHD4 CHD3 RUNX1 NOTCH2 HDAC3 CBX8 CBX6 PHC2 CCL3L1;CCL3L3;CCL3;CCL18 PHC1 IFNG MTA2 CBX4 CBX2 PHC3 MAML2 MAML1 EP300 STAT4 BMI1 IL12RB2 ASH2L RING1 IRF4 CREBBP IL5 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UPP1 TK1 DCK TYMP CDA UCKL1 UCK1 TK2 PUDP PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L CCNT2-1 SUPT5H TCEA1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 CCNK CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H CTDP1 POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX BAX BID DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V GP1BB GP5 VWF GP1BA GP9 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin HBEGF HRAS SOS1 PRKCA EGFR MMP3 NRAS COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport DYNC1I2 COPZ2 COPZ1 STX5 YKT6 DYNC1I1 DYNC1H1 DCTN2 DCTN3 GOLGA2 NSF BET1L GBF1 ARF1 ARF4-1 GOLGB1 INS;INS-IGF2 TMED3 TMED7 TMED9 ARFGAP2 ARF5 COPG2 COPG1 COPB2 TMED2-1 NAPA COPA ARCN1 KDELR3 NAPB COPB1 DCTN1 TMEM115 DYNC1LI1 COPE DYNC1LI2 GORASP1 KDELR1 NAPG KDELR2 RAB1A TMED10 RAB1B SPTAN1 GOSR2 USO1 CAPZB CD59 ANK2 ANK3 ANK1 DCTN6 SPTB DCTN5 COG8 DCTN4 COG7 CD55 COG6 CAPZA3 CAPZA1 COG5 ARFGAP1 CAPZA2 ACTR10 ACTR1A COG4 COG3 COG2 COG1 FOLR1 BET1 SPTBN4 SPTBN5 SPTA1 ARFGAP3 GOSR1 SPTBN1 SPTBN2 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway RAC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 WNT5B PSMD1 ROR1 ROR2 AP2A1 AP2A2 PRKCB PSMC2-1 PSMA5 AP2M1 PSMA6 PSMA3 PSMA4 PSMA1 VANGL2 UBA52 SCRIB PSMD12 PSMD11 PSMD14 PRKCG PSMD13 PSMA7 PSMB6 DAAM1 PSMB7 PSMB4 CLTB PSMB5 PSMB2 PSMB3 PSMB1 RPS27A AP2S1 UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 DVL1 PSMC3 PSMC4 DVL2 PSMC1 DVL3 AP2B1 CLTC CLTA WNT5A PRKCA PFN1 RYK-1 RHOA PARD6A SMURF2 SMURF1 RAC3 WNT11 PRICKLE1 WNT1 WNT4 FZD1 FZD3 FZD2 FZD5 FZD4 FZD7 FZD6 FZD8 ARRB2 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase CACNG8 CACNG7 CACNG4 KCNE2 KCNE3 KCNE4 KCNE5 KCNE1;KCNE1B CACNA1C CACNB1 CACNG6 CACNB2 AKAP9-1 CACNA2D2 KCNQ1 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L NCBP2-1 GTF2H1 SUPT5H TCEA1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CTDP1 CCNH POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors MAPK1 MAPK9 MAPK3 MAPK8 JUN FOS MAPK14 MAPK10 MAPK11 ATF2 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) RBP3 OPN1SW RLBP1 DHRS3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW AWAT2 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs CAMKK2 RAC1 CALM3;CALM1 CAMK1 GIT1 CAMKK1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MRC2 PSMC2-1 PSMA5 PSMA6 PSMA3 FCGR1A PSMA4 PSMA1 MRC1 CD207 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSME1 PSMB2 PSME2 PSMB3 PSMB1 PSMB10 ADRM1 PSMB8 PSMA2-1 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H POLR2I POLR2L GTF2H1 TAF8 GTF2F1 TAF4B GTF2H3 TAF7 GTF2F2 TAF6 GTF2H4 TAF5 CDK7 TAF4 POLR2J;POLR2J2;POLR2J3 TAF3 ERCC3 TAF2 ERCC2 TAF1 MNAT1 GTF2B TAF7L TBP GTF2A1 GTF2A2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH TAF9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C TAF15 POLR2D TAF12 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion RAD21 ESCO1 ESCO2 WAPL SMC3 STAG1 CDCA5 STAG2 PDS5B SMC1A PDS5A GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNB1 GNB4 GNB3 GNAS-1 ADCY4 PRKAR2A ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR1A ADCY5 GNG10 GNG2 GNG5 GNG4 GNG8 PRKACA-1 ADCY9 PRKACB-1 PRKAR1B GCGR PRKAR2B GCG GNG13 GNB2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters SLC39A2 SLC39A1 SLC39A3 SLC39A10 SLC39A14 SLC30A3 SLC30A2 SLC30A8 SLC30A1 SLC39A6 SLC39A5 SLC30A5 SLC39A8 SLC39A4 SLC39A7 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1;UGT1A6 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L SUPT5H TCEA1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H CTDP1 POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease FLT3 HRAS PIK3CA SOS1 GAB2 UBA52 BCL2L1 ETV6 PTPN11 FLT3LG PIK3R1 MYO18A CDKN1A RPS27A GOLGB1 TRIP11 UBB;UBC CBL STAT5A STAT5B PIM1 NOX4 GRB2 SPTBN1 NRAS ZMYM2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway RAC1 CD86 PAK1 CDC42 CD80 CD28 PAK3 PAK2 FYN VAV1 LCK G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events GNB1 MC2R DRD5 GNB4 TAAR8 GNB3 GNB5 MC4R VIP TAAR9 RAMP1 TAAR6 TAAR5 TAAR2 TAAR1 ADRB3 PDE1B PDE1A FSHB GRK2 GPBAR1 FSHR MC3R PTGER4 PTGER2 POMC CYSLTR2 GNAT3 MC1R MC5R ADCY9 PRKACA-1 SRC PRKAR1B PRKACB-1 GNAZ PRKAR2B CGA TSHB GPER1 PTGIR GPR176 CRHR2 GPR15 GPR27 GPR25 GPR20 GPR32 ADORA2B GPR45 ADCY4 GPR150 GPR83 PRKAR2A GNAI3 GPR84 PDE2A ADCY3 TSHR PDE3A ADCY2 ADCY1 PDE8B GRK3 ADCY8 PDE8A ADCY7 GNAI1 PRKAR1A GRK6 ADCY6 PDE4D-1 GNAI2 ADCY5 PDE4A PDE4C PDE11A PDE10A PDE7B PDE7A ARRB1 ARRB2 RLN3 RLN2;RLN1 INSL3 RXFP1 RXFP2 AVPR2 AVP GLP1R VIPR1 VIPR2 SCT GPR39 ADM PTH1R GNGT1 NPSR1 NPS GLP2R PTH2R P2RY11 GNAS-1 GIP ADCYAP1 PDE3B CRH IAPP CALCA ADCYAP1R1 RAMP2 CALCRL RAMP3 GIPR PTH GPHA2 CRHR1 PTHLH GHRHR GRK5 GNG10 ITGB1 CALCR GNG2 GNG5 GNG4 GNG8 GPHB5 LHCGR ADORA2A ITGA5 CALCB;CALCA GCGR ADRB1 ADRB2 HTR4 SCTR HTR6 PTGDR HTR7 HRH2 GCG GNG13 DRD1 GNB2 ADM2 LHB GHRH PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends RBBP8 ATRIP BARD1 PPP4R2 TIPIN TIMELESS RPA1 BRCC3 RPA2 PPP4C CLSPN SIRT6 TP53BP1 BABAM1 RAD50 BABAM2 RNF4 UIMC1 RPA3 ABRAXAS1 RNF8 RNF168-1 RAD17 NSD2 ATM RAD1 RAD9B RAD9A ATR UBA52 H2BC5 H2BC1 RPS27A UBB;UBC MDC1 PIAS4 CDK2 UBE2I H2BC21 UBE2V2 SUMO2 MRE11 BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC15;H2BC3;H2BC11;H2BC12 RMI2 RFC3 RFC4 RMI1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RFC2 TOP3A HUS1 DNA2 RHNO1 BLM CCNA2-1 HERC2 WRN BRIP1 CCNA1 UBE2N DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades FGB TLR10 FGA TLR5 S100A9 FGG TLR4 S100A8 IKBKB TLR1 TLR6 TLR2 IKBKG CHUK TICAM1 TRAF3 CD14 UNC93B1 TLR7 TLR3 S100A1 RELA CD36 TIRAP LY96 HMGB1-1 BTK MYD88 NFKB1 NFKBIA NFKB2 IRAK4 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism DLST MCCC2 MCCC1 PPM1K AUH IVD SLC6A12 QARS1 HIBCH SLC7A5 RARS1 AOC1 MARS1 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 HNMT DARS1 FTCD GLS2 LARS1 EEF1E1 KARS1 IARS1 TXNRD1 AIMP1 AIMP2 EPRS1 CAV1 DIO1 DIO3 TXNDC11 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 FOLH1B;FOLH1 NAALAD2 NAT8L ASPA SLC6A7 SLC25A15 CPS1 ARG1 ALDH4A1 ASL PRODH2 PRODH;LOC102724788 SIRT5 NAGS NMRAL1 GLUD1;GLUD2 ASS1 OTC HSD17B10 SHMT1 SLC25A12 SLC25A13 RIDA SDS SDSL TPH1 PIPOX AGXT PAOX DDO HAO1 MRPS36 SLC44A1 SLC44A2 DAO TP53 CRAT TPH2 ASMT AANAT ECHS1 ASNS PHYKPL BCKDK BCKDHA BCKDHB DBT DLD GPT PXMP2 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 ACAD8 HIBADH RPL15-1 RPS13 ACADSB RPS12 ALDH6A1 RPS9 BCAT1 RPL21 SLC25A44 RPS7 BCAT2 RPS8 RPL23 SLC22A4 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 DMGDH RPS4X CHDH RPL7A SARDH ALDH7A1 RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L AGXT2 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 SEPHS2 SECISBP2 EEFSEC SEPSECS RPS27 PSTK INMT SARS1 GNMT SCLY GLS QDPR IL4I1 PAH PCBD1 KYAT1 ASRGL1 GAMT PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PAPSS2 PAPSS1 GLUL GLDC PSMC2-1 HYKK PSMA5 GLYAT TDO2 PSMA6 HOGA1 PSMA3 CKMT1A;CKMT1B PSMA4 SLC6A11 IDO2 PSMA1 UBA52 IDO1 GCDH OAZ1 PSMD12 ACMSD PSMD11 AFMID PSMD14 GCSH-3 RIMKLA PSMD13 RIMKLB PYCR1 PNMT PYCR2 PYCR3 PSMA7 DDC SLC6A8 TH KYAT3 PSMB6 DBH PHGDH PSMB7 GOT1-1 AASS PSMB4 ARG2 GOT2-1 PSMB5 OAT PSMB2 GADL1 HAAO PSMB3 APIP ODC1 PSMB1 MRI1 CSAD RPS27A CKM ADO AADAT BBOX1 TXN2 ADRM1 CBS;CBSL AGMAT ENOPH1 PSMA2-1 GATM SAT1 MPST SEM1 TSTD1 PSPH BHMT2 PSMC5 KMO SQOR PSMC6 SMS FMO1 PSMC3 AZIN2 PSMC4 GRHPR SUOX MTAP PSMC1 SERINC1 BHMT SERINC3 SERINC2 TST MTRR ADI1 SERINC5 ETHE1 AHCY SERINC4 NNMT SLC25A2 CTH AMD1 SLC25A10 MTR-1 AZIN1-2 CDO1 MAT1A DHTKD1 KYNU AMT GSTZ1 ALDH9A1 SRM CKMT2 SRR SLC25A21 CRYM TMLHE PSAT1 HGD TAT FAH HPD NQO1 ACAT1 OCA2 SLC45A2 CKB DCT TYRP1 TYR SLC3A2 SLC36A4 OGDH RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription BCL2L11 SMAD2;SMAD3 SMAD4 FOXO3 RUNX3 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer AMER1 RNF43 PPP2R1B CTBP2 PPP2R1A CSNK1A1 CTBP1 PORCN DKK1 DKK2 DKK4 TCF7L2 KREMEN1 KREMEN2 LRP5 APC LRP6 TNKS TNKS2 AXIN1 PPP2CB;PPP2CA PPP2R5E FZD5 FZD4 WNT3A CTNNB1 PPP2R5B FZD6 PPP2R5A PPP2R5D PPP2R5C FZD8 GSK3B SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2;SMAD3 SMAD4 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection NCOR1 DYNC1I2 TBL1XR1 EGFR NUP43 TRIM28 DYNC1I1 HNRNPK RANBP2 DYNC1H1 SUZ12 ELK1 H2BC5 H2AC16;H2AC11 H2BC1 NUP37 PML H2AC4 NCOR2 NFKB1 CEBPD DAXX GPS2 NUP107 H2BC21 CHMP1A EED DYNC1LI1 DYNC1LI2 H2AC14 NUP205 NUP188 RBBP4 AAAS NUP42 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBX1 NUP62 NUP160 TPR RBBP7 ITGB1 NUP88 CHMP4C RAE1 NDC1 CHMP4B NUP85 NUP214 CHMP3 NUP210 CHMP4A NUP155 CHMP6 TSG101 HDAC3 NUP153 H2BC15;H2BC3;H2BC11;H2BC12 NUP93 CHMP7 NUP50 VPS4A POM121;POM121C MVB12B MVB12A NUP35 VPS36 NUP54 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VPS37C VPS37D VPS37A SNF8 VPS37B UBAP1 SEC13 VPS25 VPS28 H2AC20 NUP133 CHMP2B CHMP2A EZH2 H2BC18 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane MTMR6 MTM1 INPP5K PIP5K1A PIP5K1B PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 ARF1 PI4K2B MTMR2 PIK3CD PIK3CB PIK3CG PIK3CA PIP5K1C SYNJ2 PTEN OCRL RAB5A PIK3R3 PIK3C2A PIK3R2 PIK3R1 PIK3R6 PIK3R5 MTMR14 PIK3C2G PIK3C2B INPPL1 RAB14 SBF2 INPP5D INPP4A INPP5J RUFY1 INPP4B PIP4K2A PI4K2A PIP4K2B MTMR1 MTMR3 SYNJ1 MTMR8 RAB4A MTMR9 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation TAF13 RBBP8 TAF10 ATRIP TAF11 BARD1 SSRP1 AURKB RPA1 RPA2 TAF8 PLK3 TAF4B TAF7 RAD50 TAF6 TAF5 RPA3 TAF4 CSNK2A1;CSNK2A3 TAF3 TAF2 RAD17 TAF1 ATM RAD1 RAD9B RAD9A ATR UBA52 CDK5 TP53RK CDK5R1 RPS27A UBB;UBC TP53 NUAK1 TPX2 NOC2L CDK2 HIPK1 HIPK2 MAPK14 MAPK11 PRKAA1 PRKAA2 PIN1 MRE11 BRCA1 PRKAB2 KAT5 CSNK2A2 PRKAB1 EXO1 CSNK2B CHEK1 MAPKAPK5 DYRK2 NBN TOPBP1 MDM2-2 CHEK2 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 AURKA TOP3A HUS1 TAF7L DNA2 RHNO1 TP53INP1 SUPT16H BLM TBP MDM4 PRKAG1 PRKAG2 CCNA2-1 TAF9 WRN STK11 BRIP1 CCNA1 TAF15 PRKAG3 TAF12 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling ATP6V1C1 ATP6V1C2 ATP6V0A1 MCOLN1 STEAP3 ATP6V1F TF ATP6V0E2;ATP6V0E1 STEAP4 TFRC HFE TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols CYP46A1 CYP39A1 ARNT2 POMC CYP27A1 NR1H4 ARNT CYP4V2 CYP7B1 CYP11A1 CYP7A1 RXRA FDX1 FDXR AHR NCOA1 CYP1B1 NCOA2 CYP51A1 CYP8B1 CYP21A2 AHRR CYP11B1;CYP11B2 CYP19A1 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 E2F4-1 TOP2A CDC6 RBBP4 MYC CDC25A HDAC1 MYBL2 CDK1 LIN54 LIN52 LIN37 RBL2 LIN9 RBL1 DYRK1A E2F1 E2F5 PCNA CCNA2-1 TFDP1 MAX TFDP2 CCNE2 CCNA1 CCNE1 CDK2 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases RAC1 PELP1 EGFR RASA1 ELMO1 DOK1 EGF UBA52 EREG STAT3 BTC HBEGF RPS27A CDKN1B SFPQ-1 UBB;UBC CBL CCND1 NRG1 CDK4 CCNE1 NRAS CDK2 SOCS3 HRAS STAP2 NR3C1 KHDRBS1 KHDRBS2 KHDRBS3 RHOA CRK AKT1 EPAS1 PTK6 HIF1A ARHGAP35 SRMS ARAP1 ERBB2 NRG2 NRG3 NRG4 ELMO2 PTPN1 DOCK1 PXN BCAR1 GPNMB LRRK2 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB BIN2 KDR KANK1 GOLGA4 ETV6 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) EDEM2 EDEM1-1 MAN1B1 RNF139 SYVN1 UGGT2 RPS27A UGGT1 MARCHF6 UBB;UBC EDEM3 AMFR SEL1L RNF103 DERL2 TRIM13 RNF5 OS9 UBA52 RNF185 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers AMER1 ATG7 HDAC5 HDAC2 HDAC8 HDAC9 KIT HDAC6 HDAC1 HDAC7 CCNB1 MARK3 HDAC10 HDAC11 SRC IL10RA CBL CTNNB1 MET LRRFIP1 YWHAB NRAS RAP1A MAP2K2;MAP2K1 MAPK1 PDGFB HRAS TFG CD19 MAPK3 BRAF LMO7 FRS2 NPM1-2 RPS6KB2 SMAD4 SOS1 SHC1-1 ESR2 MRAS NR4A1 SHOC2 SEC31A CDC37 HDAC3 AXIN1 ERBB2 HES1 EP300 ITGB3 TGFBR1-1 ARAF TGFBR2 PEBP1 ARRB1 CREBBP PHB IQGAP1 ARRB2 RAP1B JAK2 TSC2 BRAP NCOR1 FGB RNF213-2 TBL1XR1 FGA KSR1 VWF FGG KSR2 AKT1S1 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 MAP3K11 VCL CALM3;CALM1 FKBP1A CARS1 JUN FOXO3 APC BCL2L11 GOLGB1 NOTCH1 RBX1 IHH SHH HGF CTBP2 CTBP1 DCTN1 DUSP10 DUSP8 DUSP9 DHH GZMH;GZMB-1 BCR ETV6 FIP1L1 BIN2 KDR FZD5 FZD4 WNT3A FZD6 FZD8 DNMT1 RRBP1 PDGFRA PSENEN PSEN2 PSEN1 APH1A SPRED3 NCSTN SPRED2 APH1B SPRED1 HES5 HEYL NF1 WDR48 RB1 DUSP16 CDKN1A CDKN1B CAMK2B CAMK2D CAMK2A FLT3 TYK2 CAMK2G PRF1 PPP1CC FOXM1 ICOS PPP2R1B ZC3HC1 PPP2R1A CLIP1 MDM2-2 TNKS TNKS2 PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CEBPB FGFR1 MAPK9 MAPK8 RANBP2 NTRK2 BDNF BAD PAPSS1 GAB1 CASP9 FRS3 NTF4 NTF3 PLCG1 EGF AREG BCL2L1 EEF1G JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NRG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 PORCN POLR2J;POLR2J2;POLR2J3 WDCP AKT2 MYC AKT3 AKT1 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 LYN YES1 ERLIN2 MOV10 AGO4 AGO2 CD28 IRF4 ZMYM2 DUSP6 DUSP7 RAC1 VAV1 AGO3;AGO1 DERL2 OS9 TENT4A AKAP9-1 RICTOR KIAA1549 MPRIP TRIM24 FXR1-1 AGTRAP AP3B1 SND1 STAT1 STAT3 ESRP1 MIB2 KDM7A FAM114A2 ZC3HAV1 VCP-1 FLT3LG TRAK1 LMNA CD86 AGK QKI CD80 CLCN6 FAM131B AGGF1 SEL1L IL10 MYH9 GSK3A PRR5 GSK3B RBPJ PIK3CD PIK3CB PIK3CG MLST8 PDPK1 PIK3CA LCK ALK EML4 PPM1B HIP1 CCNC-1 BCL11A PRKAR1A ERLEC1 EIF2AK3 STRN BIRC6 FYN CSK TCF7L2 PTPN11 MTOR TNRC6C PTPN6 HEY1 HEY2 NRG2 NRG3 NRG4 NCBP1 BCL2A1 NCBP2-1 EGFR FGFR3 SYVN1 TRIP11 CEP43 TP53 FOXO4 RNF43 CSNK1A1 DKK1 DKK2 DKK4 GCC2 GOLGA4 TPR PTEN KREMEN1 KREMEN2 LRP5 LRP6 CUX1 FGFR1OP2 MYO18A CPSF6 RHOG KLC1 ERBIN PDGFRB TRAT1 NTRK3 PIK3AP1 TGFA PPP1CB RPS6 SNW1 TGFB1 FOXO1-1 STAT5A STAT5B PIM1 NOX4 GRB2 KIF5B TPM4 CLTC TPM3 MAMLD1 HSP90AA1 KANK1 PTPN12 SMAD2;SMAD3 HHAT KRAS MAML2 MAML1 JUNB SPTBN1 MSN PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 FGFR2 CHUK PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 EREG PSMD12 BTC PSMD11 EPGN PSMD14 HBEGF PSMD13 CUL1 SQSTM1 PSMA7 PSMB6 PSMB7 PSMB4 ATIC PSMB5 BAG4 PSMB2 PSMB3 PSMB1 NCOR2 RPS27A KAT2B UBB;UBC KAT2A ADRM1 PSMA2-1 SEM1 PPFIBP1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 HDAC4 ESR1 KLB IRS1 ITGA2B IRS2 FGF1 FGF2 FGF3 FN1 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 FGFR4 FGF10 MCL1 CDK8 ZAP70 IL22 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors GNRHR GPHB5 FSHB GPHA2 LHCGR CGA TSHB FSHR GNRH1 LHB TSHR NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants KIT GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism ENPP6 PNPLA6 PNPLA7 GDPD1 GDE1 GDPD3 GDPD5 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription MAML2 HES1 MAMLD1 MAML1 EP300 NOTCH2 FCER2 GZMH;GZMB-1 HES5 RBPJ PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events MAP2K2;MAP2K1 MAPK1 MAPK3 NTRK1 KIDINS220 BRAF FRS2 NGF RAPGEF1 CRK YWHAB CRKL RAP1A DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle ARHGAP21 LMAN1 STX5 MCAM ARHGAP39 MCF2 LBR ERBIN VANGL1 ARHGAP32 DIAPH3 VAPB RTKN ARHGEF10L AKAP13 STK10 SLK ARHGEF11 TFRC ARHGEF10 ARHGEF12 FMNL3 ABCD3 ARHGEF17 CIT DAAM1 ARHGEF1 ARHGEF25 PKN3 CAV1 ARHGEF28 IQGAP3 STOM STARD13 JUP CAVIN1 ANLN TJP2 DIAPH1 DLC1 PKN2 PKN1 ARHGEF40 VAV2 RHOC ROCK1 ROCK2 RHOA ACBD5-1 FLOT1 FLOT2 ARHGAP18 BCR MACO1 ARHGAP1 ABR PIK3R1 RACGAP1 ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MYO9B MCF2L ARHGAP26 TMPO CCDC187 C1QBP DEPDC1B FMNL2 ARHGEF5 IQGAP1 VAMP3 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A RAD51B RAD51D RAD51C DNA2 SEM1 BLM RAD51AP1 WRN BRIP1 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation MAP2K2;MAP2K1 MAPK1 FGB HRAS FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B VCL LAMTOR2 FN1 LAMTOR3 WDR83 IL17RD CSK MARK3 SRC ITGB3 ARAF PEBP1 ARRB1 YWHAB IQGAP1 ARRB2 NRAS RAP1B RAP1A MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A GALNS AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade GP1BB GP5 SERPINE2 VWF SERPINA5 F10 ANO6 F11 F5 F8 PROC F9 PROS1 SERPIND1 F2 SERPINC1 GP1BA GP9 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase CDC23 UBE2S CDC26 CDC16 CDC27 CDC14A ANAPC4 CDC20 ANAPC5 ANAPC1 ANAPC2 FZR1 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A3 SLC30A2 SLC30A8 SLC30A1 SLC30A5 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation MOV10 AGO4 TNRC6C AGO2 TNRC6B PTEN TNRC6A-1 AGO3;AGO1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation GRB10 INSR MAPK1 SOS1 MAPK3 SHC1-1 INS;INS-IGF2 IRS1 IRS2 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i ALG2 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle GOLGA3 KIDINS220 FRS2 KIF14 WDR6 KTN1 FAM83B PRAG1 ANKRD26;CCDC144A;LOC105375816 VANGL1 DST FRS3 ALDH3A2 PTPN13 VANGL2 FNBP1 UBXN11 SCRIB DLG5 MUC13 PKP4 TNFAIP1 LRRC1 TXNL1 TFRC CKAP4 ARHGAP1 PIK3R2 NISCH PIK3R1 KCTD13 ARHGAP5 ARHGAP35 RBMX CAV1 RND2 UHRF1BP1L PLXND1 NUDC LEMD3 DSG1 DEPDC1B EPHA2 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin SOCS3 PTPN11 JAK2 STAT5A STAT5B IRS1 LEP STAT3 IRS2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions RAC1 JAK1 FARP2 WT1 MPHOSPH8 H2AJ PVR CDH9 HACE1 CSNK2A1;CSNK2A3 CDH7 AGO3;AGO1 FOXQ1 PRKCSH CDH6 CDH5 CDH3 TLE1 ZBTB33 SOX10 IL6ST HDAC2 GANAB PKM SUZ12 CDH10 H2BC5 CDH12 CDH13 STAT3 CDH17 CDH18 HDAC1 H2BC1 CDH19 CTSS MOGS MCRIP1 CTSB NECTIN4 NECTIN3 KLF4 NECTIN2 NECTIN1 H2AC4 MYCN SNAI2 TMEM258 SRC CTNND1 TWIST2 CDH1 CTNNB1 BANP OST4 EPS15 CBLL1 RNF19B OSTC STT3A MAPK1 VAV2 H2BC21 MAPK3 EED H2AZ2;H2AZ1 DDOST DAD1 CDC42 RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TNRC6A-1 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 ARID1A TNRC6B FURIN PCSK6 CDH2 ZEB1 TRAF7 JAK2 SIRT1 VCL KMT5A JUP SP1 ARHGEF4 CTBP2 CTBP1 BIRC2 XIAP DOCK1 HEYL ELMO1 ARHGAP32 SMARCA4 ANGPTL4 PRDM8 BHLHE22 CDH8 CTNNA1 CDH24 RB1 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 SNAI1 SEC11A SEC11C KDM1A TYK2 CANX POMT2 SPCS3 SPCS2 ZNF217 SPCS1 POMT1 TFAP2A MDM2-2 ANG ANK3 TGIF2 IL6 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 TIAM1 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ZEB2 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 PSMC5 PSMC6 DNM2 PSMC3 PSMC4 PSMC1 H2AC14 MYC CSNK2A2 CSNK2B RPN2 CDH4 RPN1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDH15 FOXA2 IL6R MTBP MOV10 ZC3H12A AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 CADM3 CADM1 CADM2 PCSK7 ZMYM2 RACK1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAQ CHEK2 CDK1 YWHAG YWHAH WEE1 YWHAE SFN YWHAZ CDC25C CCNA2-1 YWHAB CHEK1 CCNA1 CCNB1 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle CCND1 PTK6 CDK4 CDKN1B CCNE1 CDK2 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines STING1 STAT6 TBK1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking YWHAH LNPEP GRK2 YWHAZ PLA2G4A SH3GL3 SH3KBP1 STAM CBL HGS STAM2 EPS15 SH3GL2 SH3GL1 INS;INS-IGF2 YWHAB STXBP3 ARFGAP2 MCFD2 SERPINA1 PPP6C TFG PPP6R1 PPP6R3 CTSC RAB27B TMED2-1 TRAPPC2L ITSN2 TRAPPC2;TRAPPC2B RALA-1 LMAN1L SCARB2 F5 AGFG1 GAPVD1 TRAPPC6A F8 STON1-GTF2A1L BIN1 TBC1D20 AMPH TRAPPC6B SNX18-1 GPS1 GORASP1 PREB GRK3 CLTCL1 SEC22B SEC22A PACSIN2 SEC22C PACSIN3 RAB1A SNX9 PIP5K1C TMED10 KIAA0319 STX17 MYO6 LMAN2L PACSIN1 TOR1A RAB1B SYNJ2 GOSR2 USO1 TOR1B SCFD1 SYT9 LMAN2 SYT8 SNAP91 CD59 DAB2 SEC31B COPS4 SEC31A IL7R ANKRD28 PICALM STON2 TRAPPC3 COPS2 TRAPPC1 PIK3C2A TRAPPC4 SLC2A8 TRAPPC10 SGIP1 GJB1 EPS15L1 TRAPPC5 TRAPPC9 ARFGAP1 SEC23IP EPN1 CNIH1 EPN2 GAK CRYZL2P-SEC16B;SEC16B CNIH2 CTTN ARF6 FOLR1 CNIH3 LRP2 FCHO1 BET1 ALS2 FCHO2 REPS2 UBQLN1 UBQLN2 HIP1R NECAP2 APOB NECAP1 SYT11 TRIP10 MAN1A2 GJA3 MAN1C1 GJA5 MAN1A1 GJA4 ARRB1 GJA9 GJA8 GJC2 ARRB2 GJB4 GJB3 DENND1C TSC2 GJB6 DENND1B TSC1 GJB5 GDI1 GJB7 DENND5B DENND1A GJD4 MAP1LC3B2;MAP1LC3B-1 GJD3 GDI2 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 CALM3;CALM1 DENND6B RIN3 RAB38 YWHAE DENND6A APP RIN1 RIN2 RAB21 SYT2 ALS2CL CHML SYT1 CCZ1;CCZ1B ANKRD27 CPD DENND4B VAMP2 DENND4A SH3D19 GOLGA2 DENND4C TPD52 HPS1 TFRC HPS4 AP3S2;AP3S1 BLOC1S4 RAB39A BLOC1S6 RAB39B TRAPPC8 SNX2 BLOC1S3 RAB18 SNX5 RAB3GAP2 FTH1 TBC1D8B MON1A SNAPIN RAB3GAP1 MON1B SORT1 DTNBP1 SEC23A PUM1 TPD52L1 SAR1B GOLGB1 YIPF6 ACBD3 SEC24B SEC24A SEC24D-1 WNT5A SEC24C FTL-1 TF KDELR3 DCTN1 SNAP23 KDELR1 OCRL CHMP4C CHMP4B CHMP3 CHMP4A DCTN6 DCTN5 CHMP6 DCTN4 BICD1 RACGAP1 CD55 CHMP7 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 CHRM2 FZD4 ADRB2 CHMP2B CHMP2A COL7A1 CLINT1 AP2A1 AP2A2 LDLRAP1 AP2M1 AP2S1 LDLR DVL2 AP2B1 VPS45 MYO5A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1A WASL ARF5 ACTR2 ARCN1 DYNC1LI1 DYNC1LI2 ZW10 KDELR2 MYO1C GNS MIA2 KIF18A SEC13 GOSR1 SYNJ1 KIF2A KIF2C KIF2B PAFAH1B1 DYNC1I2 COPZ2 COPZ1 DYNC1I1 DYNC1H1 CENPE RAB30 RAB36 FNBP1L EGF FNBP1 GALNT2 AREG NSF GRIA1 BET1L AVPR2 AVP TJP1 SBF1 TMED3 TMED7 TMED9 COPG2 COPG1 COPB2 COPA COPB1 MAN2A2 TMEM115 COPE ALPG;ALPP;ALPI-1 AKT2 AKT3 AKT1 PRKAB2 PRKAB1 C2CD5 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 RAB10 RAB14 RAB13 RAB27A PRKAG1 PRKAG2 CD3G CD3D PRKAG3 RAC1 GOLIM4 CYTH3 CYTH2 CYTH4 GOLGA5 SNAP29 CYTH1 OPTN-1 MAN2A1 AP3B1 KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KIF6 KIF27 RINT1 KIF9 KIFC2 ARF4-1 KIFC1 KIFAP3 KIF16B KIF20B NBAS STX18 BNIP1 CSNK1D SURF4 KIF18B COPS5 KIF26B MYH9 GALNT1 KIF3B KIF3A YWHAG KIF3C PRKAA2 HIP1 RAB3IP SFN AGPAT3 CD4 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 ACTR1A VTA1 VPS37C VPS37D RABGAP1 GABARAP VPS37A SNF8 GGA2 GGA1 VPS37B RABGEF1 UBAP1 VPS25 GGA3 VPS28 TBC1D13 TBC1D10C CHMP5 TBC1D14 TBC1D17 TBC1D10A TBC1D15 TBC1D10B RAB8A RAB8B TBC1D16 GABARAPL2 EXOC8 RAB4A SYTL1 RAB33A EXOC7 RAB33B-1 RAB11B TBC1D2 RABEP1 TBC1D7;TBC1D7-LOC100130357 RAB35 TBC1D24 TBC1D25 EGFR ULK1 RAB7B PLA2G6 EXOC4 EXOC3 GJA1 EXOC6 GJB2 EXOC5 EXOC2 EXOC1 DCTN2 DCTN3 CFTR GBF1 RAB11A MIA3 TRIP11 NAPA USP6NL NAPB SCOC TMF1 SYS1 STX16 ARL1 RHOBTB3 GCC2 GCC1 RABEPK NAPG STX10 TGOLN2 ARFRP1 GOLGA4 VPS51 VPS53 VPS52 GOLGA1 VTI1A RAB5B STX6 RAB5C VPS54 ARFIP2 RAB6A RAB5A RAB6B ITSN1 NAA30 COG8 COG7 RIC1 COG6 COG5 CUX1 COG4 COG3 COG2 COG1 IGF2R RGP1 NAA35 RAB9A NAA38 VAMP4 KIF20A KLC1 RAB9B GJD2 KLC4 GJC1 KLC3 ARFGAP3 KLC2 GJA10 KIF11 KIF15 VAMP3 KIF23 RAB7A KIF22 KIF26A LMAN1 STX5 YKT6 TGFA PLIN3 KIF5B KIF5A CLTC CLTA STX4 SPTAN1 CAPZB KIF4B;KIF4A ANK2 ANK3 ANK1 SPTB YWHAQ DNM1 DNM3 CAPZA1 CAPZA2 SPTBN4 SPTBN5 SBF2 SPTA1 SPTBN1 SPTBN2 AGTR1 UBA52 EREG CHM BTC EPGN HBEGF SLC18A3 ARF1 CTSZ CLTB RAB3A AP4E1 AP4M1 AP1G2 BLOC1S1 RPS27A UBB;UBC CLVS2 AP4S1 CLVS1 TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 TACR1 COPS7B COPS7A COPS3 COPS6 COPS8 AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 MAPK1 HRAS MAPK3 SPRED2 BRAF FRS2 SPRED1 PPP2R1A FLRT3 PIK3CA FLRT2 FLRT1 FGF1 FGF2 FGF3 FGFRL1 FGF4 FGF6 GAB1 FGF9 SOS1 FGF20 FRS3 FGF23 FGF22 PLCG1 FGF18 UBA52 MKNK1 SPRY2 FGF10 PTPN11 PIK3R1 PPP2CB;PPP2CA RPS27A UBB;UBC CBL TGFBR3 ANOS1-1 GIPC1 NRAS SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways SP1 UBE2I YWHAQ YWHAG PDPK1 YWHAH CAV1 SMAD2;SMAD3 EP300 SMAD4 YWHAE PSMC6 SFN YWHAZ YWHAB SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR4 FIG4 MTMR7 PIKFYVE MTM1 PIK3C2A MTMR2 VAC14 PIK3R4 MTMR9 PIK3C3 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle ARHGAP21 LMAN1 MCAM ARHGAP39 LBR PLXNA1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 CPNE8 ANKFY1 LMNB1 SLC4A7 CAV1 FILIP1 DIAPH1 EFHD2 BUB1B-PAK6;PAK6 WHAMM STEAP3 AKAP12 HINT2 RHOD PLXNB1 TOR1AIP1 ARHGAP12 CAPZB ACTN1 ARHGAP17 ARHGAP1 PIK3R2 PIK3R1 RACGAP1 ARHGAP5 ARHGAP35 PAK5 DBN1 STBD1 ARHGAP26 EMD PGRMC2 TMPO MOSPD2 VRK2 LEMD3 ADD3 DEPDC1B VAMP3 RAB7A ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME SLC22A3 ABCB1 ADAL ABCG2 NT5C2 ADH1C;ADH1B;ADH1A SLC22A2 SLC22A1 PCK1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK HBEGF MAPK1 HRAS MAPK3 MAPK7 PRKCA EGFR RPS6KA1 MMP3 GAST SOS1 RPS6KA3 RPS6KA2 CCKBR NRAS PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription CBFB RUNX3 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF TGFA EGFR EGF AREG EREG BTC EPGN FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm BMP4 IHH FOXF1 SHH GATA4 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy VPS18 TUFM VPS33A MAP1LC3B2;MAP1LC3B-1 VPS33B VPS11 UVRAG VPS16 VPS41 VPS45 VPS39 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates LTC4S GSTM4 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling LIPG APOC3 ABCG1 CETP LCAT APOC2 ALB APOE APOA1 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 TCIRG1 SESN2 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V1G3 ATP6V1D C12orf66 SZT2 ATP6V1C1 SEH1L ATP6V1C2 NPRL2 NPRL3 ATP6V1F MLST8 WDR59 FLCN MIOS ATP6V0E2;ATP6V0E1 ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 FNIP2 CASTOR1 CASTOR2 BMT2 MTOR SEC13 RPTOR OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions SEMA3E ITGA1 SEMA4A SEMA5A CD72 PLXNA1 PLXNA4 PLXND1 PLXNC1 SEMA6A SEMA6D SEMA7A TYROBP PLXNA2 SEMA4D PTPRC ITGB1 PLXNB3 TREM2 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency ACAT1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System RNF34 NLRC4 FCER1G PML IL1RN CSF3 TNF IL12B IL12A IL10RB IL1R2 IL10RA LIF TNFRSF1B TNFRSF1A FCER2 STXBP2 A1BG LIFR KCTD6 HRG SERPINA3 NPM1-2 ORM2;ORM1 QSOX1 AHSG SMURF2 SMURF1 RAPGEF3 RAPGEF4 SMAD7 CD63 YBX1 F13A1 CFL1 CASP2 CTSV;CTSL OPRM1 IFNG PECAM1 AAMP IQGAP1 RAP1B JAK2 FGB FGA FGG RAF1 VCL LTA4H TCIRG1 FTH1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6V1B2 DBNL ATP6V0D1 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A CAND1 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D HMOX2 ATP6V1C1 ATP6V1C2 ATP6V0A1 ATP6V1F FTL-1 ATP6V0E2;ATP6V0E1 LCN2 DCTN1 ZBP1 TBK1 IRF3 NLRP4 DTX4 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB1 DEFB123 DEFB121 DEFB109B DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 DEFB114 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB110 DEFB130B;DEFB130A DEFB105A;DEFB105B AP2A1 DEFB103A;DEFB103B AP2A2 DEFB4A;DEFB4B AP2M1 MYLIP LIMK1 NPC2 PRKACB-1 AP2S1 A2M AP2B1 P4HB IDH1 TNFAIP3 CYLD TALDO1 GNS PLD3 PLPP5 PLPP4 DERA IL23R PITPNA SDC1 IL27 IL27RA PYGB SERPINB2 AIP MIF LCP1 EBI3 CNN2 PYGL HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA MANBA CSF2RB CSF2RA IL5 PGAM1 IL3RA IL2RB GAA CYB5R3 ALDOC ALDOA CD44 AGL-1 GYG1 TKFC P2RX1 IL4 IL18RAP IL13 TSLP IL7 RAG2 BRWD1 RAG1 CRLF2 MAN2B1 HPSE B4GALT1 PLAC8 HK3 PGM2 PGM1 RAB10 RAB14 NANOG;NANOGP8 GALNS PFKL IL34 IL16 IFNLR1 IFNL2;IFNL3;IFNL1 TXLNA PTPRZ1 STX3 AOC1 OPTN-1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE FLT3LG AMPD3 ITGAM ITGB2 APRT ICAM4 ICAM5 PNP-1 ITGAX ITGB7 CD47 MAOA PPM1B EIF2AK3 MMP2 COMMD9 COMMD3 SOCS6 SOCS5 RHOA ICAM2 ICAM3 RELB CLEC4M;CD209-2 RPS6KA5 ITGB1 CYFIP1 IL9 IL9R STBD1 RHOG ELMO2 DOCK2 DOCK1 VAMP3 RAB7A PLD1 IQGAP2 ARMC8 TRAT1 PIK3AP1 SH2B3 TEC LYZ-1 CST3 DGAT1 TTR TSPAN14 FABP5 ART1 DEFA6;DEFA4;DEFA5 PRSS3;PRSS2;PRSS1 KIF5B ANPEP KIF5A MME ITGAV ATP6AP2 ANXA2 PTK2 CUL2 ABL2 VASP CD180 LY86 LBP BPI NCK1 CAP1 ENAH EVL SOS2 MYO9B NEU1 CTSA ELK1 SQSTM1 ARF1 CTSZ TXNDC5 HSPA8 DNM2 VAMP8 VAMP7 GSTO1 IRS1 IL1RAPL1 PIK3R4 IRS2 FGF2 GAB2 TLR9 PIK3C3 CKAP4 CNTFR CNTF IL20RA IL20RB CSF3R IL22RA2 IL31RA IL6R IL22RA1 TOLLIP HAVCR2 CTF1 LRR1 CLCF1 CCNF IL13RA2 KEAP1 IL13RA1 CBLB UBE2L6 LGALS9C;LGALS9;LGALS9B FSCN1 DCAF1 HERC5 NDN HERC4 MCL1 HERC3 IL21R IL36A RNF115 IL36B RNF114 HERC2 IL36G HERC1 IL1F10 FBXO7 IL21 TRIM21 IL22 FBXO9 IL20 HERC6 IL25 IL26 TRAIP-1 IL24 WSB1 FBXO2 IL11 IL15 RNF123 IL19 RNF126 HECW2 IL17RE RBCK1 OSMR ANAPC13 IL17RB UBE2J2 RHOU MAP3K3 UBE2J1 RNF217 IL33 ATG7 IL31 OSM TRIM11-1 HACE1 BATF IL17C SIAH2 IL4R SIAH1 LNPEP IL11RA IL36RN MEX3C MMP1 UBAC1 FBXL8 IL1RL1 FBXL4 IL1RL2 FBXL7 PTK2B DZIP3 RNF220 DET1 LRSAM1 SH3RF1 TRIM9 ARHGAP9 ARIH2 LRRC41 RNF144B GAN RNF130 GPR75-ASB3;ASB3-1 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 FBXO15 UBE2E2 UBE4A LMO7 FAF2 FBXO10 FBXO11 KLHL41 KCTD7 RNF41 KLHL42 UBE2V2 RHOF CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 KLHL13 UBR1 FBXO44 ARHGAP45 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 UBE2O TPP2 UBA1 BLMH MOSPD2 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 RNF138-1 THOP1 RNF213-2 MGRN1 ASB13 GDI2 ASB14 RNF6 ASB11 RNF7 ASB12 ASB17 RNF4 RCHY1 ASB18 FBXL22 ASB15 ASB16 RAB31 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 ASB10 HECTD3 VHL TRIM41 RNF25 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 RAB18 ASB8 ASB9 ASB6 LNX1 TRIM36 ASB7 ASB4 TRIM37 ASB5 ASB2 TRIM32 ASB1 CHRNB4 HGF NCKAP1 WASF1-1 NCF1 NCF2 SNAP23 NCF4 ALAD CYBB CYBA DCTN6 DCTN5 DCTN4 RACGAP1 CAPZA3 ACTR10 NCKAP1L PAFAH1B2 WASF2 BAIAP2 ABI2 ABI1 C1QBP RAP1GAP PTPRC TREM2 SLC2A5 PSEN1 NCSTN HCK CD8B;CD8B2 ELMO1 TYROBP CYFIP2 WIPF1 WIPF2 WIPF3 PYCARD C3AR1 BTK MEFV NCKIPSD FCGR3A;FCGR3B PLCG2 NLRP3 MYO5A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1B ARPC1A WASL PSTPIP1 CTSG ACTR2 SYK FGR WAS FCGR1A WASF3 MYO10 P2RX7 MYO1C SUGT1 FRK IL2RG INPPL1 PLD4 INPP5D HVCN1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 NKIRAS2 IKBIP DUSP4 MEF2A DUSP3 IRAK4 VRK3 DUSP6 DUSP7 TLR10 TLR5 LRRC14 USP14 NLRX1 PELI3 PELI2 NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 KIFAP3 KIF3B KIF3A KIF3C ACTR1A CEP290 ACLY DCTN2 DCTN3 FUCA2 BPIFB2 CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR1C POLR3F POLR1D POLR3G POLR3H POLR3K RAB6A GAB3 RAP1GAP2 SIPA1 NOS3 IGF2R HLA-DOA HLA-DOB LAG3 KIF20A RAB9B KLC1 KLC4 KLC3 KLC2 OSBPL1A KIF11 KIF15 CTSO ACTR1B CTSH CTSF CTSE KIF23 KIF22 HLA-DMA HLA-DMB RILP CD74 KIF26A DUS2 FLNA STAT5A STAT5B PIM1 GRB2 POU2F1 CTSD GPR84 SPTAN1 KIF4B;KIF4A DNM1 DNM3 NCAM1 SPTBN2 MSN NFASC PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 NF2 SKP1 CHUK PRKCB FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 MALT1 CDA PSMB6 PSMB7 PSMB4 RAB3A PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 REL DNAJC5 NFKBIE NFKBIB UBE2I RORA PIAS1 SUMO1 MRE11 EIF4A2 EIF4A1 TAX1BP1 PRKCD ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 UNC93B1 ANAPC11 TLR8 TLR7 CDC23 CTSS UBE2S TLR3 LGMN CDC26 CDC16 CTSB HSP90B1 CDC27 CRP CDK1 CFD ANAPC4 C1QB ANAPC5 COLEC11 ANAPC1 COLEC10 ANAPC2 C1S C1R SH3KBP1 SRC FCN2;FCN1 MBL2-1 MASP1 CBL C1QC CDH1 GRB10 CGAS CTNNB1 DDX41 LRRFIP1 AIM2 IRF7 TRIM56 SH3GL2 PRKDC DHX9 IFI16 DHX36 STAT6 YWHAB CRKL XRCC6 NRAS XRCC5 RAP1A TREX1 MAP2K2;MAP2K1 STING1 MAPK1 SERPINA1 HRAS MAPK3 CTSC MAPK14 RALA-1 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 SEC22B SOS1 CRK SHC1-1 ARG1 ATF2 CD59 SEC31A TRAPPC1 LY96 HBD;HBB CD177 EP300 HMOX1 APOB MEF2C CREBBP CLEC4A CLEC4D CLEC4E CLEC7A CLEC6A CARD9 TLR4 NFE2L2 PPP3CA PRKCE PPP3CB PPIA RASGRP1 RASGRP3 PPP3R1 NFATC3 NFATC2 NFATC1 CALM3;CALM1 FKBP1A APP JUN FASLG SOD2 FOXO3 LMNB1 STK10 BCL2L11 CAPN1 SLC44A2 STOM RBX1 JUP DIAPH1 ADGRE5 ADGRE3 PPL ACAA1-1 SLC27A2 DSC1 BIN2 CD55 CUL3 VAPA KBTBD7 HEXB ATG12-1 GLB1 ATG5 GUSB ARSB CDKN1A CDKN1B FUCA1 ILF3 FZR1 CCND1 SKP2 FNTA BLNK JAK3 CDK4 IL1R1 IFNGR1 FLT3 IFNGR2 NUP107 TYK2 IFNAR1 CDC20 CD79B CD79A PPP2R1B PPP2R1A S1PR1 STAT2 DYNC1LI1 FNTB;CHURC1-FNTB DYNC1LI2 CENPS-CORT;CORT;CENPS NUP160 BST1 DSN1 NUP85 OTUD5 KIF18A PPP2CB;PPP2CA PPP2R5E SEC13 NUP133 PPP2R5B PPP2R5A GSN PPP2R5D PPP2R5C KIF2A BIRC5 KIF2C KIF2B DYNC1I2 NUP43 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L DYNC1I1 COLEC12 RANBP2 DYNC1H1 RAB3D RAB44 CENPE CASP9 RAB37 RAB4B NUP37 PRL RAB24 DSP CASP3 DSG1 PKP1 MTAP MLEC POLR2E ABCE1 POLR2F POLR2H POLR2L COPB1 H2AC14 AKT2 PLAUR EEA1 MYC TASL AKT3 RBSN AKT1 IRF5 PRKAB2 PROS1 CSNK2A2 PRKAB1 CD33-1 CSNK2B MRC1 TRIB3 ATF3 HSPA5 RPN2 EPAS1 MAPKAP1 RPN1 PIK3R3 PIK3R2 PIK3R1 HIF1A ALOX15 PIK3R6 PIK3R5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN CPNE3 WWTR1 JUND YES1 ERLIN1 ERLIN2 MOV10 AGO4 H2AC20 AGO2 CD28 H2AB2;H2AB3;H2AB1 EZH2 RAB27A HLA-DPB1-1 PRKAG1 PRKAG2 CD3G ASH2L IRF4 MAGT1 CD3E ATP8A1 CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 ATP11B TEAD3 ATP11A HLA-DPA1 TEAD4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FOS PDCD1LG2 VAV1 H2AJ SNAP29 B3GNT3 CSNK2A1;CSNK2A3 AGO3;AGO1 DERL3 DERL1 DERL2 PAK1 OS9 SPOP RICTOR ADA2 PAK3 PAK2 BRD4 ATP8B4 SUZ12 H2BC5 STAT1 HP;HPR STAT3 MIB2 H2BC1 FOSB VCP-1 CD86 TUSC3 CD80 LOC102723996;ICOSLG ATP7A GRAP2 MAP3K8 NEK2 H2AC4 ANO6 MYCN TMEM258 CD274 KMT2A KMT2C TCF7 SEL1L BTLA THEM4 TNFRSF14 SURF4 OST4 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B MAP3K14 RNF185 PRR5 GSK3B DPY30 PIK3CD PIK3CB PIK3CG H2BC21 WDR5 MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 DDOST APEH PIK3CA DAD1 BTNL9 BTN3A1;BTN3A3 LCK BTN1A1 IRF1 PRKAA1 BTNL2 PRKAA2 BTN2A2;BTN2A1 LEF1 LPCAT1 HLA-DQB2;HLA-DQB1 RNF5 CDC42 ERLEC1 AGPAT2 RBBP4 PLA2G2A-1 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN PLD2 CSK RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C CD4 H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 PDCD1 TNRC6B ELOC-1 ELOB TCN1 ZEB1 ASAH1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 NAPRT PDXK LAMP2 FBXO4 MT2A FBXO6 FBXW4 CCR5 CCT2 FBXW10;CDRT1 FBXW5 CD22 FBXW7 SPHK1 FBXW9 FBXW2 PLAU SERPINB6-2 TCP1 TP53 TXK CCT8 S100A9 S100A8 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 FBXL3 FBXL5 DDX58 NUP205 IFIH1 NUP188 RNF135 SIKE1 AAAS MAVS TRIM25 NUP42 NUP62 TPR NUP88 RAB5B RAE1 RAB5C KPNA1 NDC1 MMP25 NUP214 NUP210 NUP155 NUP153 CA1 NUP93 NUP50 POM121;POM121C NUP35 NUP54 ADAM8 PANX1 CALR-1 HSPA1A;HSPA1B MMP8 CXADR KPNA7 JAML KCNAB2 KPNA5 SIRPA;SIRPB1;SIRPG KPNA2 KPNA3 CD99 SELL TREM1 OLR1 KPNB1 KPNA4-1 ITGB5 TGFB1 EIF2AK2 ISG15 SIRPB1 CD300LF;CD300LD SIGLEC10;SIGLEC11;SIGLEC16 KLRC4-KLRK1;KLRK1 LAIR1;LAIR2-1 CD96 ANXA1 PIANP RPLP0 SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 CLTC OSCAR CLTA CD8A ULBP1-2 CD300E GBP2;GBP3;GBP1 NCR3LG1-1 CD226 HCST HSP90AA1 CLEC4G NCR1-1 PTPN12 DNAJC3-1 CD1D CANX CD1C CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 SLAMF6 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG KLRG1 NPDC1 SIGLEC5;SIGLEC14 KLRB1-1 KLRC4;KLRC3;KLRC2;KLRC1 CD160 CRTAM SH2D1A SH2D1B PILRA;PILRB TREML1 CD40LG TREML4 MUC12 TREML2 BLK MUC13 MUC15 KLRD1 SIGLEC1 RAET1E-1 CD200 MUC3A MUC5AC PAG1 CFP VNN1 PDZD11 MUC1 MUC2 SLC15A4 MUC7 MUC4 MUC6 EIF4A3 MUC17 MUC5B NDUFC2;NDUFC2-KCTD14 MUC20 MUC21 THOC5 MGST1 FPR2 SOX2 PRKRA TARBP2 TRPM2 F2 TRPC1 PTAFR LAMA5 FN1 VTN AP1G1 SRP14 AP1S2 AP1B1 AP1S1 KNG1 AP1S3 B2M AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSME1 MMP3 PSME2 PSMB10 PSMB8 PSMB9 CDC34 SLCO4C1 ITK TRAF6 PRKCQ FYB1 ZAP70 UBE2V1 LCP2 RASGRP2 LAT RASGRP4 UBE2D3;UBE2D2 CD101 UBE2N LAT2 TAB3 TAB2 TAB1 CSF1 RPS6KA1 TNFSF11 ARSA YWHAZ POMC SLC11A1 CPB2 CD81 C5AR2 CFI VAV3 C5AR1 C4BPA C4BPB C8B C8A NME2 CLU CPN2 CPN1 C8G VAV2 C6 C7 IMPDH1 CD19 C9 IMPDH2 CR2 GSTA3;GSTA5;GSTA1;GSTA2 CFHR1;CFHR2 SERPING1 FCER1A CFH-3 MS4A2 XDH HSP90AB1 ROCK1 ACTG1 NLRP1 RBBP6 IL7R VIM FURIN BECN1 HGSNAT CAB39 EIF4E CENPX LAMTOR2 LAMTOR1 LAMTOR3 EIF4G1 SNAP25 DHX58 STX1A RNF125 RNF216 VAMP2 FRMPD3 GMFG ABCA13 ALDH3B2;ALDH3B1 PGLYRP1 NHLRC3 MCEMP1 NOS2 SEC23A SCAMP1 SAR1B UNC13D RNASE3;RNASE2-2 PADI2 SERPINB3;SERPINB4-1 CRACR2A PRDX4 CISH S100A11 PRLR PA2G4 GHR PIGR SOCS2 SERPINB1 GBP6 NFAM1 TMC6 SEC24B PLEKHO2 SEC24A SERPINB10 SERPINB12 GRN SEC24D-1 AGA ERP44 LRG1 YPEL5 GHDC TMEM179B EPX LAMP1 SEC24C TOM1 KCMF1 OLFM4 ARL8A BRI3 PTPRB NIT2 GM2A ACP3 RNASET2 TMBIM1 CANT1 CASP8 FGL2 CASP1 PRCP CPPED1 VPS35L C6orf120 KRT1 METTL7A-1 PCBP2 SLPI RIPK3 CRISPLD2 IL18 TMEM63A BST2 TRAF2 SYNGR1 IL1A IL1B VAT1 IRF2 PTPRN2 STK11IP PELI1 PRG2 NBEAL2 ARIH1 PRG3 S100A7A;S100A7 PTPRJ GLIPR1 CAMP HNRNPA2B1 BIRC2 CD53 IL17F RAP2B BIRC3 IL17A PRKN DNASE1L1 CSTB C1orf35 PPIE PGRMC1 SDCBP HMGB1-1 ATAD3A;ATAD3B CREG1 RIPK1 ORMDL3 GCA PTGES2 FADD SVIP ELANE QPCT GSDMD CASP5;CASP4 CD68 ITCH MPO DYNLT1 COTL1 ENPP4 MMP9 OSTF1 CD93 STUB1 IRAG2 DOK3 GBP7;GBP4 GSDME ADGRG3 DPP7 GGH DNAJC13 TARM1 DEGS1 MS4A3 TNFAIP6 ATG14 CRISP3 HEBP2 CHI3L1 CLEC12A MVP TMEM30A CMTM6 PDAP1 S100P PTX3 HNRNPF GLA HSPA9 DDX3X-1 UBE2B CLEC5A AHCYL1 EIF4G3 EIF4G2 EIF4E3 PRKACA-1 NOS1 SNRPA1 CEBPD STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ITPR1 ITPR2 ITPR3 CAMK2G TOMM70 IL17RC IL17RA TLR1 TLR6 TLR2 PDIA3 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 LTF TXN MAP2K7 MAP2K6 IL6 CXCL8 MAPK9 MAPK8 MAPK7 IFNB1-4 MAPK10 SP100 PTPN22 PTPN18 IL37 PTPN20 PTPN23 PLCG1 PTPN13 PTPN14 IL18BP BCL2 SIGIRR PTPN9 BCL2L1 PTPN7 PTPN5 PTPN2 IL18R1 EEF1A1 S100A1 CD36 IRAK3 EEF2 TIRAP ADAM10 ADAM17 CCL13;CCL2 ALOX5 PTGS2-2 C5 PRDX6 C3-1 LOC110384692;C4A;C4B_2;C4B CFB C2 MGAM PGLYRP4 PGLYRP3 PGLYRP2 CHIT1 SLA2 SLA TNFRSF8 GSTP1 TNFRSF4 TNFRSF17 TNFRSF9 LEAP2 TNFSF13B ATOX1 TNFRSF25 SOD1 TNFSF18 TNFSF14 EIF2S2 TNFSF15 EIF2S3;EIF2S3B DAPP1 EDARADD EIF2S1 EDAR EPPIN;EPPIN-WFDC6 LPO LTA LTB RNASE6 RNASE7 TNFRSF11B TNFRSF11A ITLN2;ITLN1-2 ERAP2 ERAP1 BPIFA1 REG3G;REG3A-1 BPIFB1 BPIFB4 BPIFB6 CD27 TNFRSF13B TNFRSF13C EDA2R TNFRSF12A CD70 EDA CHGA TNFSF4 TNFSF9 TNFSF8 SIGLEC15 LTBR PVR PRKCSH IL6ST PKM GOLGA7-1 NECTIN2 IFIT5 IFI35 IFI30 IFIT1 IFIT3 IFIT2 ICAM1 TRIM29 TRIM26 FAAP100 RSAD2 PDE12 TRIM14 TRIM10 ATF6 IL10 EGR1 MX1-1 TRIM8 MYH9 TRIM6 TIFA TRIM5 ALPK1 TRIM2 TRIM3 RNASEL FAAP24 LOC105377022;FANCB PGGT1B FLNB HSPA1L IFI44L ILF2 MID1 IFITM3;IFITM2;IFITM1 GBP5-1 IP6K2 VCAM1 FANCM FANCL TXNIP FANCA HSPA2 FANCE GATA3 FANCG FANCF ISG20 CIITA ADAR OASL SFN TRIM68 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 OAS1 OAS3 IRF8 IRF6 EIF4E2 IRF9 SAMHD1 TRIM46 COL1A2 SNCA TRIM45 TRIM35 TRIM38 TRIM31 IST1 CASP10 TBC1D10C PLA2G6 CR1L;CR1 RORC FPR1 SOCS3 CXCL2;CXCL3;CXCL1-1 CCL11 FBXO32 CCL4L2;CCL4L1;CCL4 CCL19 PIN1 CCL22 PTEN ITGAL CCL20 TRIM63 ITGA4 APAF1 TNFRSF18 CCL3L1;CCL3L3;CCL3;CCL18 PSAP CXCL10 CCL5 PTPN1 IL2RA PTPN4 CCR1 PPBP LGALS3 CCR6 CCR2 OPRD1 CXCR1 SMARCA4 CXCR2 CTSK FOXO1-1 VEGFA IRAK1 SMAD2;SMAD3 SEC61A2 MRC2 SEC61A1 SEC61G SEC61B TAP2 TAP1 TAPBP IL2 STX4 IL3 CD207 CAPZB CAT CAPZA1 CAPZA2 RETN TIMP2 TIMP1 KRAS JUNB RNF111 NEDD4L CDK13 GPI UBE2D3-1 HSPA6 F12 KLKB1 WWP1 CSF2 FKBP5 CSF1R ABL1 FANCC BCL6 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription POLR2E POU2F1 POLR3E POLR2F POLR1C POLR3F POLR2H POLR1D POLR3G POLR2L POLR3H BDP1 POLR3K SSB NFIX SNAPC5 NFIA SNAPC1 NFIB SNAPC2 NFIC SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 GTF3C2 GTF3C3 CRCP TBP GTF3C4 GTF3C5 BRF1 POLR3GL GTF3A GTF3C6-1 POLR3A POLR3B POLR3C POLR3D RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CBFB PRKCB RUNX1 LGALS3 CSF2 CREBBP CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system IL25 TAB2 IL26 TAB1 CSF1 IL24 IL11 IL15 IL19 IL17RE RPS6KA1 OSMR IL17RB TNFSF11 RHOU MAP3K3 IL33 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IL1RL2 PTK2B PRKCD YWHAZ UBE2E1 UBE2D1 HSP90B1 POMC CDK1 PML IL1RN CSF3 TNF IL12B SRC IL12A NEDD4 IL10RB IL1R2 IL10RA CBL GRB10 LIF TNFRSF1B TNFRSF1A FCER2 IRF7 DHX9 STAT6 CRKL NRAS MAP2K2;MAP2K1 STXBP2 MAPK1 HRAS MAPK3 GSTA3;GSTA5;GSTA1;GSTA2 MAPK14 LIFR RALA-1 MAPK11 CUL5 NPM1-2 MAPKAPK3 UBA7 MAPKAPK2 RAPGEF1 SOS1 CRK ACTG1 SHC1-1 SMAD7 SOCS1 ATF2 YBX1 IL7R F13A1 CFL1 OPRM1 VIM IFNG UBA3 HMOX1 FURIN MEF2C RAP1B JAK2 BECN1 RNF7 RAF1 PPIA EIF4E CENPX EIF4G1 SNAP25 APP JUN FASLG SOD2 FOXO3 STX1A LMNB1 VAMP2 BCL2L11 NOS2 RBX1 CISH PRLR GHR SOCS2 GBP6 HGF LCN2 TBK1 IRF3 CASP8 CASP1 IL18 TRAF2 BST2 IL1A IL1B IRF2 PELI1 ARIH1 PTPRJ HNRNPA2B1 BIRC2 IL17F BIRC3 IL17A HMGB1-1 GSDMD MMP9 GBP7;GBP4 HNRNPF HCK HSPA9 EIF4G3 EIF4G2 EIF4E3 PRKACA-1 CDKN1A CDKN1B ILF3 SNRPA1 CCND1 CEBPD PLCG2 CAMK2B CAMK2D CAMK2A FNTA BLNK JAK3 P4HB IL1R1 IFNGR1 IFNGR2 FLT3 NUP107 TYK2 CAMK2G IFNAR1 CTSG IL17RC IL17RA SYK PPP2R1B PPP2R1A S1PR1 STAT2 FNTB;CHURC1-FNTB TALDO1 CENPS-CORT;CORT;CENPS RPS6KA3 RPS6KA2 MAP2K3 FCGR1A MAP2K4 NUP160 NUP85 MAP2K7 MAP2K6 IL23R PPP2CB;PPP2CA PITPNA SDC1 IL27 IL2RG IL27RA SERPINB2 INPPL1 AIP MIF SEC13 LCP1 EBI3 INPP5D NUP133 CNN2 IL6 HNRNPDL PPP2R5A STAT4 CXCL8 PPP2R5D IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB BIRC5 CSF2RA IL5 IL3RA IL2RB MAPK9 MAPK8 MAPK7 NUP43 IFNB1-4 SP100 RANBP2 MAPK10 CD44 PTPN18 IL37 PTPN20 PTPN23 PLCG1 PTPN13 PTPN14 IL18BP BCL2 SIGIRR PTPN9 BCL2L1 PTPN7 PTPN5 PTPN2 IL18R1 NUP37 PRL CD36 IRAK3 ADAM17 CASP3 MTAP IL4 IL18RAP ABCE1 CCL13;CCL2 IL13 ALOX5 PTGS2-2 TSLP IL7 RAG2 BRWD1 RAG1 CRLF2 SLA2 AKT2 MYC SLA AKT3 TNFRSF8 AKT1 TNFRSF4 IRF5 TNFRSF17 TNFRSF9 TNFSF13B TNFRSF25 SOD1 TNFSF18 HSPA5 TNFSF14 EIF2S2 EIF2S3;EIF2S3B TNFSF15 EDARADD EIF2S1 EDAR PIK3R3 PIK3R2 PIK3R1 HIF1A LTA ALOX15 LTB H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN TNFRSF11B TNFRSF11A RIPK2 YES1 MYD88 CD27 ATF1 TNFRSF13B TNFRSF13C HLA-DPB1-1 EDA2R SAA2;SAA1 NKIRAS1 TNFRSF12A NKIRAS2 CD70 IKBIP EDA DUSP4 IRF4 MEF2A TNFSF4 TNFSF9 DUSP3 TNFSF8 IRAK4 VRK3 DUSP6 LTBR NANOG;NANOGP8 DUSP7 JAK1 LRRC14 USP14 NLRX1 HLA-DPA1 PELI3 PELI2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FOS NLRC5 NOD1 IL34 NOD2 IL16 VAV1 IFNLR1 AGER IFNL2;IFNL3;IFNL1 IRAK2 S100A12 TXLNA PTPRZ1 N4BP1 STX3 TNIP2 USP18;USP41 IL6ST TRAF3 PAK2 STAT1 STAT3 FLT3LG CD86 CD80 GRAP2 MAP3K8 IFIT5 IFI35 IFI30 IFIT1 IFIT3 IFIT2 ICAM1 TRIM29 TRIM26 FAAP100 RSAD2 PDE12 TNFRSF14 ITGAM TRIM14 ITGB2 TRIM10 ATF6 NFKB2 IL10 EGR1 MX1-1 TRIM8 TRIM6 HLA-DRA TRIM5 TIFA TRIM2 MAP3K14 ITGAX ALPK1 TRIM3 RNASEL FAAP24 LOC105377022;FANCB PIK3CD PGGT1B FLNB PIK3CB HSPA1L IFI44L ILF2 MID1 IFITM3;IFITM2;IFITM1 GBP5-1 IP6K2 VCAM1 FANCM FANCL PIK3CA FANCA LCK HSPA2 FANCE IRF1 GATA3 FANCG MAOA FANCF ISG20 CIITA PPM1B HLA-DQB2;HLA-DQB1 ADAR CDC42 OASL SFN TRIM68 EIF2AK3 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 OAS1 OAS3 FYN IRF8 CSK IRF6 EIF4E2 IRF9 SAMHD1 COL1A2 TRIM46 PTPN11 SNCA TRIM45 TRIM35 TRIM38 CD4 TRIM31 PTPN6 ELOC-1 ELOB MMP2 ZEB1 MT2A CCR5 RORC SPHK1 TCP1 TP53 SOCS6 SOCS5 FPR1 SOCS3 CXCL2;CXCL3;CXCL1-1 ACTB-1 CCL11 CCL4L2;CCL4L1;CCL4 CCL19 DDX58 NUP205 IFIH1 PIN1 NUP188 RELB AAAS MAVS RPS6KA5 TRIM25 NUP42 NUP62 CCL22 TPR NUP88 CCL20 ITGB1 RAE1 KPNA1 NDC1 NUP214 NUP210 NUP155 IL9 NUP153 IL9R NUP93 CA1 NUP50 TNFRSF18 GAB3 POM121;POM121C NUP35 CCL3L1;CCL3L3;CCL3;CCL18 NUP54 CXCL10 CCL5 PTPN1 HSPA1A;HSPA1B IL2RA PTPN4 CCR1 KPNA7 KPNA5 DUS2 KPNA2 CCR2 SH2B3 KPNA3 TEC OPRD1 FLNA SMARCA4 KPNB1 KPNA4-1 TGFB1 EIF2AK2 FOXO1-1 ISG15 STAT5A STAT5B PIM1 GRB2 ANXA1 VEGFA RPLP0 ANXA2 POU2F1 GBP2;GBP3;GBP1 HSP90AA1 PTPN12 DNAJC3-1 CANX ABL2 IRAK1 LBP SMAD2;SMAD3 NCK1 IL2 STX4 IL3 CD40LG SOS2 CAPZA1 TIMP1 KRAS MUC1 NCAM1 JUNB EIF4A3 MSN THOC5 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ELK1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 UBE2D3-1 SQSTM1 SOX2 RELA PSMA7 PSMB6 ARF1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PRKRA RPS27A TARBP2 UBB;UBC ADRM1 NFKB1 PSMA2-1 HSPA8 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 VAMP7 PSMC4 PSMC1 NFKBIB GSTO1 PTAFR UBE2I RORA LAMA5 IRS1 PIAS1 CSF2 IL1RAPL1 IRS2 FGF2 SUMO1 FN1 GAB2 B2M HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E FKBP5 CSF1R CNTFR CNTF IL20RA MMP3 PSME2 IL20RB CSF3R IL22RA2 IL31RA IL22RA1 IL6R TOLLIP HAVCR2 CTF1 PSMB8 CLCF1 IL13RA2 IL13RA1 EIF4A2 LGALS9C;LGALS9;LGALS9B EIF4A1 UBE2L6 FSCN1 NDN HERC5 MCL1 FANCC TRAF6 IL21R IL36A IL36B UBE2V1 IL36G IL1F10 UBE2D3;UBE2D2 IL21 BCL6 TRIM21 IL22 UBE2N IL20 TAB3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling HBEGF HRAS SOS1 SHC1-1 TGFA EGFR EGF AREG EREG BTC NRAS EPGN PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism PITPNB MBOAT1 ETNPPL ETNK2 ETNK1 PNPLA3 CSNK2A1;CSNK2A3 PLA2G4A AGK PIK3CD PIK3CB PIK3CG PIK3CA PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 LCLAT1 AGPAT2 PLA2G2A-1 PIP5K1C AGPAT3 AGPAT4 PLD2 GPAT4 SYNJ2 LIPI ACP6 LIPH AGPAT5-1 GPAT3 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PIK3C2A PLA2G2D PLA2G12A PLA2G2E MIGA2 MIGA1 PLA2G4D DDHD2 GPD1L-1 DDHD1 GNPAT CDS1 PITPNM1 LPCAT4 PITPNM3 GPD1 PITPNM2 PLA2R1 CDIPT RAB4A MBOAT7 PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PNPLA8 MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPAM PNPLA2 INPP5E PTEN OCRL RAB5A TAZ PLD1 GPAT2 DGAT2 DGAT1 GPD2 LPIN1 LPIN2 LPIN3 MGLL PLD3 MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 INPPL1 TNFAIP8L3 PLD4 TNFAIP8L2 ENPP6 INPP5D SBF2 INPP4A INPP5J RUFY1 INPP4B PIP4K2A PI4K2A PIP4K2B VAC14 MTMR1 MTMR3 SYNJ1 MTMR8 STARD7 GDPD1 MTMR9 GDPD3 GDPD5 MTMR4 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 TPTE;TPTE2 PLEKHA6 PLEKHA3 HADHA PLEKHA4 HADHB-1 BMX PLEKHA8 FIG4 PIKFYVE PNPLA6 PI4KB PTPN13 ACHE PIP4P1 ARF1 BCHE PTDSS2 PTDSS1 AWAT2 PI4K2B CHAT MTMR2 SACM1L PI4KA SBF1 PIK3R4 ALPG;ALPP;ALPI-1 CSNK2A2 CSNK2B PIK3C3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 LPGAT1 PIK3R5 CPNE7 CPNE6 CPNE3 PCYT2 PISD PLA2G15 PGP PCTP PLA1A CEPT1 MFSD2A ABHD4 PGS1 PCYT1B RAB14 PTPMT1 CHKB PCYT1A OSBPL8 CHKA OSBPL5 STARD10 DGAT2L6 ABHD3-2 CRLS1 CDS2 PHOSPHO1 PEMT OSBPL10 PLAAT1 CHPT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 SELENOI DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins MOGS GLB1 NEU1 MAN1B1 DPAGT1 CTSA ALG8 ALG9 ALG6 ALG2 ALG3 B4GALT1 ALG12 ALG1 MPDU1 RFT1 ALG11 MGAT2 ALG14 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A4 ARL2 SLC28A1 SLC28A2 SLC25A5 SLC29A1 SLC25A4 SLC28A3 SLC25A6 ARL2BP SLC29A2 SLC29A3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth COL4A3 COL9A1 CNTN2 COL6A3 COL4A5 ARTN ST8SIA4 COL9A3 COL6A6 GFRA2 COL6A5 GFRA4 COL9A2 ST8SIA2 NRTN NCAN CACNA1S PRNP PSPN AGRN CACNB1 CACNA1H CACNB2 CACNB3 CACNA1G CACNB4 CACNA1I NRAS PTK2 MAPK1 HRAS MAPK3 CACNA1C SOS1 RPS6KA5 FYN SPTAN1 GFRA1 CACNA1D SPTB GDNF SPTBN4 SPTBN5 SPTA1 NCAM1 COL4A2 COL4A1 SPTBN1 SPTBN2 COL6A2 PTPRA COL4A4 COL6A1 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle ARHGAP21 PAK4 SRGAP2 MPP7 LAMTOR1 GJA1 PAK1 VANGL1 ARHGAP32 DIAPH3 CPNE8 PAK2 FNBP1 CFTR SCRIB CDC42BPB CDC42BPA TFRC SLC4A7 CDC42EP4 CDC42EP3 CDC42EP2 CAV1 IQGAP3 STOM GOPC JUP DLC1 STEAP3 WASL ARHGEF7 SNAP23 SYDE1 CDC42 GIT1 ARL13B ARHGAP17 ITSN1 ARHGAP1 WWP2 ARHGAP5 ARHGAP33 ARHGAP35 PREX1 OPHN1 GIT2 ARHGAP26 PLEKHG3 SLC1A5 DEPDC1B CDC42EP1 TRIP10 IQGAP1 VAMP3 RAB7A THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome CASP1 PYCARD AIM2 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP4B CHMP3 CHMP4A BECN1 MAP1LC3B2;MAP1LC3B-1 CHMP6 UVRAG CHMP7 PIK3R4 CHMP2B CHMP2A PIK3C3 CHMP4C SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CASP7 CASP3 CASP9 APAF1 DIABLO-1 XIAP CYCS-1 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins EID3 RNF2 RPA1 NUP43 NSMCE4A CDKN2A SP100 RANBP2 RNF168-1 RAD52 XRCC4 HDAC7 NUP37 PML MDC1 PIAS4 UBE2I PCGF2 NUP107 SMC3 PARP1 PIAS1 XPC SUMO1 SUMO3 SUMO2 NUP205 NUP188 BRCA1 AAAS NUP42 NUP62 NUP160 TPR NUP88 TDG RAE1 NDC1 NUP85 NUP214 RAD21 NUP210 CETN2 NUP155 NUP153 NUP93 NUP50 CBX8 POM121;POM121C STAG1 PHC2 STAG2 NUP35 NUP54 PHC1 CBX4 CBX2 PHC3 SEC13 NUP133 BLM BMI1 SMC1A SMC5 SMC6 HERC2 RING1 WRN NSMCE3 NSMCE2 NSMCE1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells BMP4 NANOG;NANOGP8 NANOS3 CXCR4 PRDM1 CBFA2T2 PDPN TET2 POU5F1;POU5F1B EOMES TFAP2C SOX17 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor IDE GAB1 FLT3LG TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6AP1 GRB10 ATP6V1B2 INSR ATP6V0D1 THEM4 ATP6V0D2 ATP6V0C ATP6V1B1 PTPRF ATP6V1A INS;INS-IGF2 ATP6V0A2 ATP6V1H ATP6V0A4 NRAS ATP6V1G3 ATP6V1D FLT3 PIK3CB MAPK1 ATP6V1C1 ATP6V1C2 CTSD HRAS ATP6V0A1 MAPK3 ATP6V1F PDPK1 FRS2 KLB ATP6V0E2;ATP6V0E1 IRS1 PDE3B PIK3CA PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 SOS1 AKT2 FGF20 FGF23 SHC1-1 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 FGF10 PTPN11 PIK3R2 PIK3R1 PTPN1 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants FLT3 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids SMPD3 SMPD2 STS ARSA SIN3A LBR SUMF2 SUMF1 PLA2G4A ARSL ARSJ ARSK ARSH ARSI LGMN TXNRD1 ARSG POMC ARSD-1 CAV1 CGA ARNT2 ACBD5-1 MAPKAPK2 RGL1 PIP5K1C DHRS7B SYNJ2 GC SMARCD3 PIK3C2A HDAC3 CHD9 SMPD1 NPAS2 ARNTL HELZ2 SRD5A2 CDS1 SRD5A1 LRP2 PITPNM1 PITPNM3 CYP17A1 PITPNM2 TGS1 CDIPT EP300 ACOXL PPARGC1A NCOA1 MED1 NCOA2 ECI1 CREBBP ACADM DECR1 NCOA6 APOA1 NR1D1 CYP19A1 NCOR1 TBL1XR1 MECR CARM1 CLOCK HPGD LTA4H PECR CYP2D6;LOC107987479;LOC107987478-1 CYP2J2-1 CYP2C9;CYP2C19 CROT AHR SCP2 NUDT19 CYP1A2 CYP1A1 AHRR BAAT CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ACOX2 AGPS TM7SF2 HMGCS1-1 ACOX3 GGPS1 ELOVL6 PHYH-4 LSS SREBF2 ALDH3B2;ALDH3B1 MTF1 HACL1 SLC44A5 MVD ACOT2;ACOT1 IDI1 SEC23A SLC44A3 EPHX2 MVK SAR1B SLC44A4 INSIG2 ACSL1 SLC44A1 INSIG1 SLC44A2 NUDT7 ACACB AMACR PEX11A ACACA CRAT PMVK SC5D SCAP FDFT1 ABCG2 CIDEC FDPS MBTPS1 SEC24B SEC24A MED19 NFYB MED18 NFYC CYP51A1 MED11 ELOVL5 SEC24D-1 SQLE MED29 MED22 GPAM MED21 SP1 SCD NFYA-1 DHCR7 THRSP SEC24C PNPLA2 CYP27A1 MBTPS2 TIAM2 HSD3B7 AKR1D1 NR1H4 CYP7B1 CYP7A1 GM2A ALAS1 ACOT8 EHHADH-1 MED13L ACAA1-1 HSD17B4 DECR2 ABCD1 SLC27A2 OCRL ACOT4 ABCB4 GLIPR1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ORMDL3 PTGES2 ABCB11 TAZ SLC22A5 DEGS1 MED9 CDK19 GLA IDI2 SCD5 MSMO1 VAPA HSD17B7 MED28-1 ACAT2 NSDHL ARV1 EBP LDLRAP1 DHCR24 PLPP6 HEXB CUBN LTC4S HEXA APOA2 GLB1L3 GLB1L2 APOA5 GLB1L GLB1 ANGPTL4 GGT1 ARSB PRKACA-1 PRKACB-1 DPEP2 DPEP1 ABCA1 NR1H3 GGT5 ACBD4 HSD11B1 ALB HSD11B2 SERPINA6 CERK GBA2 OSBP PPP1CC MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 UGCG UGT8 SGPL1 B4GALNT1 KDSR B3GALNT1 ACER2 ACER1 FA2H ACER3 DEGS2 GAL3ST1 SMPD4 SPTLC1 SPTLC3 ALOX12 A4GALT CERS3 CERS4 CERS5 CERS6 NDUFAB1 SPHK2 PLD3 CERS1 CERS2 SAMD8 SULT2A1-4 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB ORMDL1 INPPL1 PLD4 SGPP2 SGPP1 AKR1B1 GALC CH25H INPP5D OSBPL9 INPP5J OSBPL7 OSBPL6 OSBPL3 OSBPL2 HSD17B11 SYNJ1 HSD17B2 B3GNT5 PTPN13 CD36 PTDSS2 AWAT2 PTDSS1 PI4K2B MTMR2 SACM1L PI4KA SBF1 FUT2 FUT1 ALOX5 B3GALT4 PTGS2-2 ME1 ABCC3 GPX1 ALPG;ALPP;ALPI-1 FDX1 FDXR PRKAB2 CSNK2A2 CSNK2B TRIB3 PIK3R3 PIK3R2 PIK3R1 ABCC1 PIK3R6 ALOX15 SLC25A17 CYP4B1 LPGAT1 PIK3R5 CYP4F22 CPNE7 CYP11A1 B4GALT6 CPNE6 ALOX5AP CPNE3 PTGR1-1 PCYT2 PISD PLA2G15 PGP B4GALT5 ST6GALNAC6 PLA1A ABHD4 RAB14 PGS1 PTPMT1 OSBPL8 OSBPL5 DGAT2L6 CRLS1 CDS2 PRKAG2 OSBPL10 PLAAT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 SELENOI MBOAT1 PITPNB ETNPPL ETNK2 ACOT9 ETNK1 ACOT7 PNPLA3 FAR1 FAR2 HSD17B1 MCAT PRXL2B PTGR2 PTGS1 G0S2 THEM5 FHL2 CSNK2A1;CSNK2A3 FAAH2 TNFRSF21 HSD17B13 AWAT1 SLC25A20 MID1IP1 CPT1A FAAH ACAD11 ACAD10 CPT1B PTGES ALOX15B ANKRD1 PTGIS TBXAS1 FITM1 FITM2 CYP8B1 STARD3 GRHL1 STARD4 ST3GAL2 CBR1-1 STARD6 ST3GAL3 ACAA2 STARD3NL ACOT11 STAR ACOT12 TSPO ACOT13 AGK ACBD7 ACBD6 ACSF2 CPT2 PON3 ELOVL3 PON2 CIDEA PON1 THEM4 MCEE PCCA MMAA PCCB MMUT PIK3CD PIK3CB PIK3CG NRF1 THRAP3 AKR1B15;AKR1B10 FAM120B PIK3CA PRKAA2 PLA2G1B LPCAT1 PLA2G5 PLD6 CCNC-1 AGPAT1 LCLAT1 AGPAT2 PPARGC1B PLA2G2A-1 AGPAT3 AGPAT4 PLD2 GPAT4 HSD3B1;HSD3B2 CYP24A1 LIPI CYP21A2 ACP6 CYP11B1;CYP11B2 LIPH AGPAT5-1 GPAT3 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLA2G12A MED16 PLA2G2E MED15 MIGA2 MIGA1 HACD1 MED17 PLA2G4D MED12 DDHD2 TECR GPD1L-1 MED14 HSD17B3 MED13 HSD17B12 DDHD1 HACD3 GNPAT LPCAT4 HSD17B8 HACD2 MED10 GPD1 HACD4 PLA2R1 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 MED27 ACSL5 MED26 ACSL4 ACSL3 ELOVL7 MED23 RAB4A TECRL MED25 ACSF3 ACLY PPT1 MED24 MED20 ACSBG1 PPT2 ASAH1 PPARD SLC27A3 ACSBG2 MBOAT7 PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PNPLA8 MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 PLIN2 SPHK1 CYP2R1 GBA MED30 ECHS1 ACSM3 HADH ACADS CSNK1G2 INPP5E PTEN RAB5A ARNT PSAP SLCO1A2 OSBPL1A LHB PLD1 FADS2 FADS1 VAPB MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 KPNB1 FABP4 FABP5 FABP6 FABP7 SREBF1 GPD2 PLIN3 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 RXRB LPIN3 MGLL CYP2U1 CYP1B1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 MED31-1 NCOA3 ACADVL PTGES3-1 RAN MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G STARD5 PIK3C2B SLC10A1 TNFAIP8L1 SLC10A2 TNFAIP8L3 FASN SLC51A TNFAIP8L2 SLC51B ENPP6 SLC27A5 SBF2 INPP4A RUFY1 INPP4B PIP4K2A PI4K2A PIP4K2B VAC14 MTMR1 MTMR3 MTMR8 STARD7 GDPD1 MED8 MTMR9 ST6GALNAC5 MED4 GDPD3 MED6 GDPD5 MED7 MTMR4 MTMR6 MTMR7 NEU2 MTM1 NEU3 INPP5F INPP5K PIP5K1A PIP5K1B NEU1 PLEKHA1 PNPLA7 ST3GAL5 PLEKHA2 ST8SIA5 PLEKHA5 TPTE;TPTE2 CTSA PLEKHA6 PLEKHA3 HADHA PLEKHA4 BMX HADHB-1 ACADL PLEKHA8 FIG4 PIKFYVE SRD5A3 PNPLA6 PI4KB ACHE PIP4P1 ARF1 BCHE NCOR2 M6PR CHAT GPS2 HPGDS TSPOAP1 GSTM4 PIAS4 UBE2I VDR NR1H2 RORA AGT PIK3R4 RXRA SUMO2 PPARG PPARA HMGCL ACSS3 BDH2 BDH1 OXCT1-1 HMGCS2 GPX4 PIK3C3 HMGCLL1 ALOX12B AACS ALOXE3 ACAT1 CYP46A1 CYP39A1 CYP27B1 PTGDS PCTP CEPT1 MFSD2A PCYT1B CHKB ESRRA PCYT1A CHKA STARD10 ABHD3-2 PHOSPHO1 SLC27A1 PEMT CDK8 CHPT1 SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants HRAS NRAS KRAS SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions SLC25A1 SLC13A2 SLC13A3 SLCO1C1 SLC5A12 SLC17A5 SLC13A5 BSG SLCO2A1 SLC44A5 SLC22A6 SLC22A12 SLC5A8 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC5A7 SLC10A6 AVP SLC44A3 SLCO1A2 SLC44A4 SLC22A8 SLC44A1 SLC44A2 SLC22A11 SLC16A1 SLC16A7 SLCO4A1 SLC16A8 EMB SLC16A3 SLCO4C1 SLCO2B1 SLC25A10 SLC16A2 SLC25A11 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 CYP17A1 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation LTF DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o DPM1 DPM2 DPM3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes KANSL1 HCFC1 KANSL2 KANSL3 WDR5 CXXC1 MCRS1 SETD1B SETD1A KDM6A PAXIP1 MEN1 PSIP1 PAGR1 RBBP5 PHF20 KAT8 KMT2A BOD1L2;BOD1 KMT2C OGT-1 KAT2B HCFC2 KAT2A WDR82 BOD1L1 MBIP TASP1 DR1 TADA2A ZZZ3 KMT2D YEATS2 TADA3 AKAP8L ASH2L SGF29 NCOA6 KMT2B PHF20L1 DPY30 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism GDA DNPH1 NUDT15 NT5C XDH NT5C1A NT5C1B;NT5C1B-RDH14 NUDT16 NUDT5 ADPRM NT5C2 PNP-1 NT5E ITPA REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NKX2-2 INSM1 NEUROG3 NEUROD1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade DUSP6 TAB2 DUSP7 TAB1 TLR10 TLR5 LRRC14 MAPK9 USP14 MAPK8 NLRX1 MAPK7 RPS6KA1 PELI3 IKBKB PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 IKBKG S100A12 MAPK10 BTRC N4BP1 MAP3K7 MAP3K1 SKP1 TNIP2 CHUK USP18;USP41 FBXW11 APP JUN ELK1 UBA52 CUL1 RELA MAP3K8 RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKB2 TIFA ALPK1 NFKBIB MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 CASP8 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 RPS6KA5 MAP2K3 MAP2K4 TRAF2 ATF2 PELI1 MAP2K7 MAP2K6 PPP2CB;PPP2CA HMGB1-1 RIPK2 MYD88 ATF1 ECSIT PPP2R5D SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 IKBIP UBE2V1 DUSP4 MEF2C MEF2A DUSP3 IRAK4 UBE2N VRK3 TAB3 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k ALG1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle CSKMT FXN SDHC SDHD SDHA SDHB IDH2 SDHAF2 SDHAF3 CS SDHAF1 SDHAF4 ISCA2 ACO2 ISCA1 SIRT3 LYRM4 ACAT1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication MAP1LC3B2;MAP1LC3B-1 BTF3 NPLOC4 EIF4E HDLBP KPNA7 KPNA5 KPNA2 EIF4G1 KPNA3 UBA52 IPO7 NMT1 VCP-1 TUSC3 BAG2 P4HA1 P4HA2 P4HA3 KPNB1 EIF4G3 ACOT2;ACOT1 EIF4G2 EIF4E3 TMEM258 KPNA4-1 RPS27A XRN1 UBB;UBC HSPA8 SCAP OST4 SEC11A SEC11C OSTC STT3A HYOU1 DNAJA2 STT3B P4HB ATL2 UBE2I PRKG2 DNAJC3-1 CANX DDOST NACA DAD1 SPCS3 SPCS2 SUMO1 PABPC1;PABPC3 SPCS1 PDIA3 DNAJC10 UFD1 HSPA5 KPNA1 RPN2 YBX1 RPN1 VIM DNAJB11 XPO1 RTN3 FASN SUN2 EIF4A2 EIF4A1 RRBP1 DPM1 DPM2 CALR-1 MAGT1 DPM3 EIF4A3 HSPA1A;HSPA1B APOA1 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs BARD1 STAMBPL1 BRCC3 H2AC4 BABAM1 BABAM2 UIMC1 RPS27A ABRAXAS1 STAM KAT2B UBB;UBC MYSM1 H2AC20 EP300 H2AC14 BRCA1 ABRAXAS2 NLRP3 H2AC16;H2AC11 UBA52 STAMBP PSMD14 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development CSF1 MC4R HINT1 EDNRB QARS1 SMARCB1 RPS6KA1 ZIC1 TNFSF11 SOX9 YWHAH SIN3A FOXD3 SMARCC1 EDN1 SMARCC2 RARS1 GPR143 EDN3 AGO3;AGO1 TFE3 MARS1 TFEB PAX3 MITF SOX10 SMARCD1 POU3F2 YWHAZ SMARCD2 DARS1 MC3R LARS1 PLK1 TFEC KIT EEF1E1 HDAC1 CCNB1 KARS1 ALX3 SMARCA2 IARS1 MARK3 SMARCA4 SMARCE1 TBX3 POMC AIMP1 AIMP2 MC1R EPRS1 ID1 MC5R SNAI2 CDKN1A TCF7 CDH1 GMPR CCND1 CTNNB1 MET STT3B MYO5A YWHAB GSK3B CDK2 MAPK1 MAPK3 YWHAG MAPK14 USF1 LEF1 TFAP2A TCF7L2 TCF7L1 TNRC6A-1 SMARCD3 TNRC6C ARID1A TNRC6B ARID1B LIG1 XPO1 SERPINE1 EP300 MCM5 MCM2 PPARGC1A ACTL6A GXYLT2 CDH2 PXN TERT CREBBP EDIL3 ZEB1 PXDN SIRT1 BIRC7 ASAH1 BCL2A1 TBX2 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 CDKN2A YWHAE BCL2 CDC25B SOX2 ATP6V1E1 ATP6V1G1 ATP6V0B DICER1 TRPM1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A DIAPH1 ATP6V1H ATP6V1C1 UBE2I ATP6V0E2;ATP6V0E1 ACTB-1 SUMO1 AKT2 AKT3 BRCA1 DCT ITGA2 TYRP1 TYR PMEL BCL7A WNT3A MLANA MOV10 BCL7C DPF1 AGO4 BCL7B DPF2 AGO2 DPF3 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis PANK3 PANK1 DCAKD COASY PPCDC PPCS DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex TLE5 PSMD8 AMER1 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 TLE1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 HDAC1 PSMD14 APC PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC TCF7 ADRM1 RBX1 PSMA2-1 SEM1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 TLE4 PSMC1 TLE2 TLE3 ZRANB1 GSK3B FRAT2 PPP2R1B PPP2R1A CTBP2 CSNK1A1 CTBP1 LEF1 TCF7L2 TCF7L1 AXIN1 PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy ATG12-1 MAP1LC3B2;MAP1LC3B-1 ATG5 ULK1 CSNK2A2 CSNK2B MAP1LC3A CSNK2A1;CSNK2A3 FUNDC1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events GNB1 GNB4 GNB3 GNB5 ADRA2C PRKCA ADRA2B PRKCH ADRA2A GNAS-1 PRKCE ADCY4 GNAI3 RGSL1 ADCY3 RGS4 ADCY2 ADCY1 ADCY8 ADCY7 PRKCB GNAI1 ADCY6 GNAI2 ADCY5 PRKCD GNG10 RGS20 GNG2 GNG5 PRKCG GNG4 GNG8 GNAT3 RGS17 RGS19 ADCY9 RGS16 GNAZ PRKCQ GNGT1 GNG13 GNB2 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 MAN1B1 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria MAPK8 BMF SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo STK4 WWTR1 SAV1 STK3 LATS1 MOB1A;MOB1B LATS2 AMOTL2 TJP1 AMOTL1 CASP3 WWC1 YWHAE YAP1-1 DVL2 TJP2 YWHAB NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity PTPN2 HGF PTPRJ LRIG1 USP8 SH3GL3 SH3KBP1 RPS27A STAM UBB;UBC CBL HGS STAM2 MET EPS15 SH3GL2 SH3GL1 PTPN1 UBA52 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease HRAS PIK3R1 FRS2 PIK3CA FGFR3 FGF1 FGF2 FGF4 GAB1 FGF9 SOS1 FGF20 FGF23 FGF16 PLCG1 FGF18 NRAS SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO3 UBE2I SUMO2 RWDD3 UBA2 SAE1 SUMO1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) DLST TRAP1 FXN IDH3G NNT SUCLA2 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH ACAT1 DLD CSKMT SDHC SDHD SDHA SDHB MRPS36 IDH2 CS IDH3B ISCA2 IDH3A ACO2 ISCA1 SIRT3 LYRM4 MDH2 SUCLG2 OGDH SUCLG1 SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK ALKAL2 PIK3CB LTK ALKAL1 TNK2 PIK3R2 SOS1 PIK3R1 GRB2 IRS1 PIK3CA ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins ART1 DEFA6;DEFA4;DEFA5 PRSS3;PRSS2;PRSS1 CD4 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation CHUK TASL IKBKB IRF5 SLC15A4 IKBKG SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin PIK3CD JAK2 PIK3CB PIK3CG HRAS PIK3R1 PIK3R5 LYN VAV1 PIK3CA IRS2 STAT5A GAB1 RAPGEF1 STAT5B SOS1 EPOR SHC1-1 PLCG2 PLCG1 EPO CRKL NRAS CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock CSNK2A1;CSNK2A3 TFEB CPT1A F7 UBE2D1 PPP1CB PPP1CA KMT2A SREBF1 CSNK1D RBM4;RBM4B DBP CIPC SIK1;SIK1B PPP1CC ATF2 CRTC2 SMARCD3 CRTC3 HDAC3 CHD9 CRTC1 NPAS2 ARNTL HELZ2 RAI1 TGS1 NRIP1 SERPINE1 EP300 NAMPT PPARGC1A MEF2D NCOA1 MED1 NCOA2 MEF2C CREBBP NCOA6 NR1D1 SIRT1 NCOR1 TBL1XR1 CARM1 PSMD8 CLOCK PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 BHLHE41 CUL1 ARNTL2 CDK5 NOCT RORC KLF15 RORB BHLHE40 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 AVP PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 PER2 SEM1 PER1 CRY2 CRY1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RORA TPTEP2-CSNK1E;CSNK1E RXRA FBXL3 PPARA CSNK2A2 CSNK2B TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation RELA IKBKB AGER HMGB1-1 S100A12 IKBKG MAP3K1 NFKB1 CHUK NFKBIA DDX58 NFKB2 IFIH1 APP RNF135 SAA2;SAA1 MAVS NKIRAS1 TRAF6 NKIRAS2 TRIM25 TRAF2 NFKBIB SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) PAX6 GPR119 ISL1 DPP4 GIP SPCS3 GATA4 SPCS2 SPCS1 PCSK1 FFAR1 SEC11A SEC11C DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) GAA PHKB GYG2 GYG1 PYGB AGL-1 CALM3;CALM1 PYGM PYGL PHKA1 PHKG1 PHKA2 PHKG2 PGM1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins CES1 ENPEP CPB1 CTSD CTSG ACE CTSZ AGT REN CPB2 CMA1 ANPEP CPA3 ACE2 MME ATP6AP2 GZMH-1 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation MOV10 AGO4 TNRC6C AGO2 NPAS4 TNRC6B TNRC6A-1 AGO3;AGO1 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events RAC1 RPS6KA1 CALM3;CALM1 KPNA2 GRIN2B RPS6KA6 CASK GRIA1 LIN7A LIN7C LIN7B GRIA3 ACTN2 GRIA4 GRIN2C GRIN3B PRKACA-1 SRC PPM1E PRKAR1B PPM1F PRKACB-1 GRIN3A GRIN1 NBEA GRIN2D GRIN2A DLG2 RASGRF2 CAMK4 RASGRF1 NEFL KIF17 CAMK1 NRGN PRKAR2B CAMK2B CAMK2D CAMK2A GRIA2 NRG1 NRAS CAMKK1 CAMKK2 MAPK1 HRAS CAMK2G MAPK3 DLG1 DLG3 PDPK1 DLG4 PRKAR2A PRKAA1 PRKX PRKAA2 ADCY1 ADCY8 PRKAR1A RPS6KA3 RPS6KA2 GIT1 PRKAB2 PRKAB1 APBA1 PRKAG1 PRKAG2 PRKAG3 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development MAPK1 MAPK3 AR SMAD1 SMAD4 SP7 SMAD6 YAP1-1 HDAC6 COL1A1 GLI3 CBFB GLI2 HDAC3 UCMA RBM14 ZNF521 RB1 WWTR1 SRC ABL1 HEY1 YES1 HEY2 HES1 SATB2 MAF IHH HDAC4 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism RIMKLA RIMKLB PYCR1 PYCR2 GLS PYCR3 GLUL GOT2-1 GLS2 KYAT1 OAT GLUD1;GLUD2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis PGAM2 PGM2L1 PFKL NUP43 GNPDA1 ALDOC ALDOB PGK1 GNPDA2 PFKM ALDOA PFKP RANBP2 GPI NUP37 PRKACA-1 PRKACB-1 GAPDHS PFKFB2 PFKFB1 PFKFB4 PFKFB3 GCK GCKR NUP107 ENO1 ENO2 ENO3 PPP2R1B ENO4 PPP2R1A ADPGK HK2 NUP205 NUP188 HK1 HK3 AAAS GAPDH-1 NUP42 NUP62 NUP160 TPR NUP88 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 BPGM NUP153 NUP93 HKDC1 NUP50 POM121;POM121C NUP35 NUP54 PPP2CB;PPP2CA SEC13 NUP133 PPP2R5D TPI1 PGAM1 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AA1 PPP1CA PPP1CC KPNB1 SPCS3 HSP90AB1 SPCS2 CSNK2A1;CSNK2A3 XPO1 SPCS1 HSPA8 FURIN SEC11A SEC11C CSNK2A2 CSNK2B PPP1CB REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism SIRT1 PPARGC1A ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling NTN1 TRPC7 TRPC5 PLCG1 TRPC6 TRPC3 DCC PITPNA TRPC4 TRPC1 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 XRN1 EXOSC1 DCP2-1 DCP1A MAPKAPK2 TNPO1 ZFP36 YWHAB FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production KIF22 RAC1 KIF26A SIN3A SH2B3 SH2B2 HDAC2 HDAC1 KIF12 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KIF6 KIF27 PRKACA-1 KIF9 PRKAR1B KIFC2 PRKACB-1 KIFC1 KIFAP3 KIF16B ZFPM1 KIF20B PRKAR2B KIF18B KIF26B KIF5B HBG2;HBG1 KIF5A JMJD1C AK3 VPS45 KDM1A GATA5 HMG20B MICAL1 CARMIL1 EHD1 CDK2 EHD2 EHD3 MAFF KIF3B AKAP10 KIF3A SH2B1 CABLES2 PHF21A KIF3C PRKAR2A GATA4 IRF1 GATA3 RCOR1 GATA2 GATA1 CBX5 CDC42 PRKAR1A DOCK11 GATA6 KIF4B;KIF4A CAPZB KIF18A CAPZA1 HBD;HBB CAPZA2 DOCK6 DOCK9 MFN1 MFN2 MYB ITPK1 DOCK7 KIF2A KIF2C KIF2B JAK2 MAFK NFE2 IFNB1-4 DOCK3 CENPE DOCK8 CDK5 AKAP1 TP53 MAFG DOCK10 RBSN IRF2 DOCK5 DOCK4 RAB5A ZFPM2 RACGAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CABLES1 ABL1 WEE1 RAD51B RAD51C KIF20A KLC1 KLC4 KLC3 KLC2 KIF11 KIF15 DOCK2 DOCK1 KIF23 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis HCFC1 NCOR1 TBL1XR1 CARM1 SIRT4 ATP5F1B CALM3;CALM1 SOD2 ACSS2 IDH2 CAMK4 NRF1 RXRA TFAM-1 ALAS1 TFB2M PPARA PPARGC1B GABPA SIRT5 PPRC1 GLUD1;GLUD2 PERM1 ATF2 CRTC2 TFB1M SMARCD3 CRTC3 HDAC3 CHD9 CRTC1 POLRMT POLG2 CYCS-1 HELZ2 TWNK TGS1 SSBP1 ESRRA PPARGC1A MEF2D MTERF1-1 NCOA1 MED1 NCOA2 MEF2C SIRT3 CREBBP NCOA6 NR1D1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs LTA4H ALOX5 PTGS2-2 ALOX15 HPGD DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU FMO3 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization PERP KRTAP24-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 KRTAP3-1 KRT16;KRT14 KRT71 KRT4 KRT2 KRT79 KRT8 KRT7 KRT78 KRT77 KRT5 KRT75 KRT74 KRT73 KRT9 KRT72 KRTAP13-1;KRTAP13-2 KRT6B;KRT6C;KRT6A KRT10-2 KRTAP27-1 KRT40 KRTAP4-3 KRTAP13-4;KRTAP23-1;KRTAP13-3-1 KRTAP16-1 KRTAP8-1 KRT81;KRT83-1 KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRTAP9-4;KRTAP9-3;KRTAP9-8;KRTAP9-7;KRTAP9-6;KRTAP9-2;KRTAP9-9-1 KRTAP26-1 KRT24 KRT23 KRT20 KRT33A;KRT33B;KRT31-2 KRT28 KRT27 KRT26 KRT25 KRTAP11-1 KRTAP3-2;KRTAP3-3-1 KRT32 KRTAP19-5 KRT3;KRT76 KRT39 KRT36 KRT82 KRT80 FURIN PCSK6 KRTAP29-1 KRT85 KRT84 KRTAP10-8 KRT13 KRT12 KRT19 KRT18 KRT17 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 KRT15 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 PKP4 CAPNS1 CAPN1 DSP JUP DSG1 PKP1 DSG2 DSG3 KLK13 SPRR3 CSTA KLK5 EVPL KLK8 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 TGM1 CASP14 LIPJ SPRR1A;SPRR1B LIPN LIPM PRSS8 LIPK TGM5 ST14 CDSN SPINK6 SPINK5 KLK14 KRT1 KAZN CELA2B;CELA2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER MCFD2 SERPINA1 SEC24C LMAN1 CTSC STX5 TMED2-1 LMAN1L F5 F8 PREB SEC22B TMED10 TGFA LMAN2L GOSR2 AREG LMAN2 CD59 MIA2 GRIA1 CTSZ MIA3 CNIH1 SEC23A CNIH2 SAR1B FOLR1 CNIH3 SEC24B SEC24A COL7A1 SEC24D-1 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation NDUFAB1 MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 C12orf65 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MIEF1 MRPS22 MALSU1 MTFMT MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MTIF2 MRPL47 MTIF3 MRPL48 MRPS7 MTRES1 MRPL46 MRPS6 MRPS5 MRPL43 TUFM MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS36 MRPS33 MRPL18 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 LOC107987373;MRPL23 MRPL30 GFM2 MTRF1 MTRF1L MRRF ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated DUSP6 MAPK1 DUSP7 MAPK3 MAPK7 PPP2R5D PPP2R1B PPP2R1A DUSP4 PPP2CB;PPP2CA DUSP3 VRK3 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling JAK2 TYK2 STAT4 IL12RB1 IL23R IL12B STAT3 P4HB DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 TLR3 RELA IKBKB ZBP1 RIPK1 IKBKG MYD88 NFKB1 CHUK NFKBIA TICAM1 NFKB2 RIPK3 NKIRAS1 DHX9 NKIRAS2 NFKBIB HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs DYNC1I2 HSPA1L HSP90AA1 NR3C1 PTGES3-1 NR3C2 DNAJA4 DYNC1I1 DCTN1 DNAJA1-1 HSPA2 AR HSP90AB1 DYNC1LI1 STIP1 DYNC1H1 DYNC1LI2 PGR DCTN2 DCTN3 CAPZB FKBP5 DCTN6 DCTN5 DCTN4 CAPZA3 CAPZA1 DNAJB1 CAPZA2 ACTR10 ACTR1A HSPA8 DNAJA2 HSPA1A;HSPA1B FKBP4 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins AURKB PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PTTG1;PTTG2 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 PLK1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CCNB1 CDC23 PSMD13 MAD2L1 CUL1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 NEK2 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 RB1 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 FBXO5 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 CDK2 BUB1B CDC20 CDC14A AURKA CCNA2-1 CCNA1 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD2 FASTKD5 TBRG4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 DCP1A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 PPP2R2A;PPP2R2D RPS4X RPL7A RPLP2 RPL36-1 RPS3A GSPT2 PPP2R1A GSPT1 RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 UPF2 FAU RPL26L1 ETF1 RPS27 PPP2CB;PPP2CA NCBP1 UPF1 EIF4A3 CASC3 SMG1 SMG9 NCBP2-1 SMG7 SMG8 SMG5 SMG6 RBM8A EIF4G1 UBA52 MAGOH;MAGOHB UPF3B RNPS1 RPS27A RPL4 RPL30 RPL3 RPL32 RPL31 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 ARHGEF6 PAK1 CDC42 GNG13 GNGT1 GNG10 GNB2 GNG2 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants KIT SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors ZNF350;ZNF432 PIAS3 MRTFA UBE2I PCGF2 RNF2 HIPK2 ZNF131 TRIM28 SAFB PIAS1 CTBP1 SIN3A UHRF2 SUMO1 NPM1-2 SUMO3 SUMO2 CASP8AP2 MBD1 PARK7 ING2 CBX8 PHC2 PHC1 CBX4 CBX2 TOPORS NCOR2 PHC3 NRIP1 EP300 PPARGC1A BMI1 DAXX NCOA1 NCOA2 RING1 DDX17 CREBBP PIAS4 DDX5 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix SPOCK3 CAPN13 COL9A1 CAPN14 PSEN1 CAPN11 CAPN12 NCSTN CAPN10 COL9A3 COL9A2 MMP1 CMA1 DCN BCAN CTSS CTSB CTSK CDH1 A2M PRSS3;PRSS2;PRSS1 CTSD CTSG ADAM15 ADAMTS4 ADAMTS5 HSPG2 ADAMTS1 ADAMTS8 CTRB1;CTRB2 ADAMTS9 CTSV;CTSL TIMP2 TIMP1 MMP14 ADAMTS16 MMP16 FURIN MMP2 ADAMTS18 PLG MMP13 SPP1 CD44 KLK3;KLK2 CAST MMP7 BMP1 TLL2 TLL1 CAPNS1 CAPNS2 CAPN2 CAPN1 ADAM10 ADAM17 CASP3 KLKB1 LAMA5 LAMB3 LAMA3 LAMB1 LAMC2 LAMC1 PHYKPL BSG OPTC KLK7 MMP20 MMP25 MMP24 COL17A1 MMP10 COL18A1 MMP12 NID1 MMP11 COL15A1 COL16A1 MMP15 COL13A1 MMP17 COL14A1 MMP19 MMP3 COL12A1 TPSAB1;TPSB2;TPSD1 TMPRSS6 CAPN8 COL19A1 CAPN9 COL26A1 CAPN6 CAPN7 ELANE CAPN5 COL25A1 CAPN3 COL23A1 ADAM9 ADAM8 ACAN MMP9 HTRA1 SCUBE3 SCUBE1 MMP8 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism APRT HPRT1 PNP-1 ADA G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 KCNJ2 KCNJ3 KCNJ12;KCNJ18 KCNJ4 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 KCNJ9 KCNJ15 KCNJ16 GNG13 GNGT1 GNG10 GNB2 GNG2 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B3 SLC35B2 PAPSS2 SLC26A2 PAPSS1 SLC26A1 SLC26A11 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2J2-1 CYP2C9;CYP2C19 CYP1B1 CYP1A2 CYP1A1 EPHX2 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 CYP2S1 CYP2E1 CYP2F1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling ARPC3 RAC1 ACTR3-1 ARPC1B ARPC1A HRAS WASL KALRN ACTR2 ACTB-1 RASA1 ROCK1 ROCK2 RHOA PAK1 CDC42 GRIN2B ACTG1 TIAM1 FYN LIMK2 SDC2 LIMK1 ITSN1 CFL1 LYN ARHGEF28 YES1 GRIN1 ARPC4 ARPC5 PTK2 ARPC2 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) POLD2 RPA1 RPA2 TCEA1 POLE4 RPA3 POLE2 POLE3 ISY1;ISY1-RAB43 UBA52 XAB2 DDB1 XRCC1 LIG3 CUL4A CUL4B RPS27A UBB;UBC RBX1 COPS5 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D UVSSA AQR ZNF830 POLR2E POLR2F POLR2G PRPF19 POLR2H ERCC5;BIVM-ERCC5 POLR2I POLR2L ERCC6 GTF2H1 XPA GTF2H3 COPS7B COPS7A GTF2H4 ERCC8 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 GPS1 COPS3 MNAT1 COPS6 ERCC4 ERCC1 COPS8 USP7 POLK POLE COPS4 COPS2 RFC5 RFC3 RFC4 RFC1 ELL RFC2 PPIE LIG1 PCNA POLD3 POLD4 POLD1 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport RBP1 RETSAT AKR1B15;AKR1B10 PLB1 GPC1 CLPS HSPG2 GPC3 PNLIP APOM RDH11 GPC2 APOA2 SDC4 GPC5 APOA4 SDC2 APOE GPC4 SDC3 GPC6 AGRN TTR LRP1 LPL LRP8 SDC1 LRP2 LDLR GPIHBP1 BCO2 LRAT APOB BCO1 APOC3 LRP10 APOC2 LRP12 APOA1 RBP4 RBP2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 TICAM2 TICAM1 CD14 TLR7 MAP3K8 NFKB2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C MAPK9 MAPK8 TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB CASP8 RPS6KA5 TRAF2 TLR9 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ PPBP APOOL FLNA CFD ACTN2 TGFB1 A2M BRPF3-1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 ABCC4 SYTL4 VEGFA CD109 ALB TAGLN2 CLU NHLRC2 STXBP3 TEX264 STXBP2 LY6G6F;LY6G6F-LY6G6D SERPINA1 PDGFB ENDOD1 A1BG APOH PRKCA PFN1 VTI1B SERPING1 RAB27B MANF CALU MAGED2 HRG F5 FERMT3 SERPINA3 F8 ECM1 OLA1 CTSW ORM2;ORM1 TIMP3 QSOX1 AHSG ANXA5 TOR4A CD63 CAP1 SPP2 STX4 VEGFB VEGFC ACTN1 VEGFD LHFPL2 PCYOX1L F13A1 CFL1 FAM3C LEFTY2;LEFTY1 APLP2 TMX3 TTN-1 SELENOP SCG3 TIMP1 TGFB2 RARRES2 CYRIB THBS1 SELP SCCPDH LGALS3BP WDR1 SERPINE1 PLEK PHACTR2 SRGN MMRN1 PECAM1 ITIH4 ITGB3 ITIH3 PLG CLEC3B CDC37L1 APOA1 FGB FGA TGFB3 VWF FGG PPIA TLN1 ALDOA VCL CALM3;CALM1 PRKCB APP CD9 LAMP2 EGF PRKCG IGF2 IGF1 CD36 TUBA4A PCDH7 HGF TF ITGA2B FN1 PROS1 PF4;PF4V1-1 KNG1 SOD1 HSPA5 CYB5R1 GAS6 PSAP DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland PRL TGFA EGF AREG FGF10 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 AKAP5 ROBO2 PRKCA PPP3CB PRKACA-1 PRKAR2A PRKACB-1 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE TLR3 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes BCL2L11 NFYA-1 BBC3 DDIT3 FOXO1-1 EP300 CITED2 FASLG NFYB NFYC FOXO3 CREBBP STK11 PINK1 BCL6 FOXO4 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A7 SLC26A4 SLC26A1 SLC26A3 SLC26A11 SLC26A9 SLC26A6 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors TNFSF11 TNFRSF8 FASLG TNFRSF4 TNFRSF17 TNFRSF9 TNFSF13B TNFRSF25 TNFSF18 TNFSF14 TNFSF15 EDARADD EDAR LTA TNFRSF18 TNFRSF11B TNFRSF1B TNFRSF1A TNFRSF14 CD27 TNFRSF13B EDA2R CD70 EDA TNFSF4 TNFSF9 TNFSF8 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 TNIP2 USP18;USP41 OPTN-1 TICAM1 TANK TRAF3 IKBKE UBE2D1 TLR3 MAP3K8 NFKB2 IRF7 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 PPP2CB;PPP2CA PPP2R5D MEF2C MAPK9 MAPK8 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 UBE2D3-1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB TBK1 IRF3 CASP8 RIPK3 RPS6KA5 TRAF2 BIRC2 BIRC3 HMGB1-1 RIPK1 RIPK2 FADD ATF1 SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2D3;UBE2D2 UBE2N VRK3 TAB3 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) YWHAG PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CUL3 CSNK2A1;CSNK2A3 SPOP PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 CSNK2A2 PSMA1 UBA52 CSNK2B PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CD274 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 CCND1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDK4 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants DUSP6 MAPK1 DUSP8 DUSP7 DUSP9 DUSP10 DUSP16 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases FLT3 FLT3LG SYK FYN HCK LCK DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18-1 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors ADORA3 ADORA1 ADORA2B ADORA2A MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling HGF GAB1 MET PIK3R1 PIK3CA NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism NUDT15 NT5C XDH AGXT2 NT5C1A DPYS DPYD NT5M UPP1 UPB1 TYMP NT5E SAMHD1 GDA DNPH1 ENTPD1 ENTPD5 ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 NUDT16 NT5C1B;NT5C1B-RDH14 NUDT5 ADPRM NT5C2 PNP-1 ITPA NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase PDE10A KCNMB2 KCNMB3 KCNMB4 PDE5A PRKG2 KCNMB1 GUCY1B1 KCNMA1 NOS2 NOS3 IRAG1 PDE9A NOS1 PDE2A PDE1B PDE1A GUCY1A2 GUCY1A1 ITPR1 PDE11A REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition CDH1 SOX2 SERPINE1 ITGA2 GXYLT2 CDH2 STT3B PXN EDIL3 ZEB1 PXDN DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A RAD51B RAD51D RAD51C DNA2 SEM1 BLM RAD51AP1 WRN BRIP1 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes ARIH1 FKBP5 IFI44L IKBKB IKBKG ISG15 UBA7 CHUK DDX58 UBE2L6 IFIH1 ATF6 EIF2AK3 HERC5 TRIM25 HSPA5 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome PSMD8 PSMD6 PSMD7 CSNK1A1 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 GLI2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PRKACA-1 PSMB1 PRKACB-1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GSK3B DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 PTPN11 HRAS PIK3R1 FRS2 KLB PIK3CA FGF1 FGF2 FGF4 FGF6 GAB1 FGF9 SOS1 FRS3 FGF20 FGF23 FGF16 PLCG1 FGF19 FGF18 NRAS FGFR4 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division RAD21 WAPL SMC3 STAG1 STAG2 KIF20A NIPBL PDS5B SMC1A PLK1 PDS5A MAU2 KIF23 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation LIG4 XRCC4 PSIP1 BANF1 XRCC6 XRCC5 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT GALT RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation SSRP1 CDK9 NCBP2-1 CCNT2-1 TCEA1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 CCNK CCNT1 ELL AFF4 ELOC-1 MLLT1 MLLT3 ELOA SUPT6H ELOB IWS1 NELFB EAF1 NELFA EAF2 NELFCD NELFE SUPT16H NCBP1 CTDP1 SUPT4H1-1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PIK3CD CD19 CD79B CD79A SYK VAV1 CALM3;CALM1 PIK3AP1 SOS1 NCK1 FYN BLK DAPP1 AHCYL1 PIK3R1 PTPN6 CD22 LYN SH3KBP1 BTK STIM1 ORAI2 ORAI1 PLCG2 ITPR1 BLNK ITPR2 ITPR3 TRPC1 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis TERF2IP RBBP8 RPA1 RPA2 SYCP1 SYNE2 RAD50 SYNE1 H2AJ RAD51 SUN1 RPA3 TEX12 SMC1B TERF1-1 SYCP3-2 SYCE2 ATM SYCE1 FKBP6 REC8 STAG3 SYCP2-1 ATR H2BC5 LMNB1 H2BC1 MLH1 H2AC4 SPO11 PSMC3IP MND1 MLH3 MSH4 DMC1 MSH5 CDK4 CDK2 UBE2I H2BC21 SMC3 H2AZ2;H2AZ1 HSPA2 H2AC14 MRE11 BRCA1 BRCA2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TINF2 NBN RAD21 H2BC15;H2BC3;H2BC11;H2BC12 STAG1 STAG2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD TOP3A RAD51C SUN2 H2AC20 BLM C1orf112 H2AB2;H2AB3;H2AB1 SMC1A PRDM7;PRDM9 TERF2 FIGNL1 POT1 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation RPS6 RPL8 ZC3H15 RWDD1 KDM8 OGFOD1 JMJD4 RIOX1 JMJD7 RIOX2 DRG1 DRG2 JMJD6 ASPH RPL27A F9 RCCD1 U2AF2 RPS23 ETF1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface PDZD11 ATP7A SLC11A1 ATOX1 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation ADCY4 PRKACA-1 ADCY9 PRKAR2A PRKACB-1 PRKAR1B ADCY3 NBEA ADCY2 ADCY1 ADCY8 CALM3;CALM1 ADCY7 ADCY6 PRKAR1A PRKAR2B ADCY5 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 CYP21A2 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 KHDRBS1 KHDRBS2 KHDRBS3 SFPQ-1 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport MB CYGB NGB REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PAK2 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 ARHGAP10 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 OMA1 PSMC6 PSMC3 PSMC4 OPA1 PSMC1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 UBA52 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS TUSC3 GOLGA7-1 MGAT4C ZDHHC9 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 TMEM258 RPS27A UBB;UBC OST4 OSTC STT3A STT3B GSK3A PARP6 PRMT1 PARP4 GSK3B GALNT1 PARP16 PARP9 UBE2I PARP14 PARP8 PARP10 CANX DDOST CSNK1A1 DAD1 SUMO1 SRPK2 SRPK1 RPN2 RPN1 MAGT1 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A DNAJC3-1 RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 RPL4 RPL30 RPL3 RPL32 RPL31 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors HBA2;HBA1 HSP90AA1 FTL-1 S100A9 COLEC12 MSR1 SCARA5 MARCO SCGB3A2 HPX AMBP HP;HPR APOE JCHAIN COL1A1 COL1A2 CD36 HSP90B1 PRDX1 FTH1 COLEC11 LRP1 HBD;HBB HSPH1 HMGB1-1 MASP1 STAB1 APOL3;APOL4;APOL1;APOL2 CD5L STAB2 SSC5D SPARC APOB COL3A1 CD163 SAA2;SAA1 COL4A2 SCARF1 COL4A1 HYOU1 CALR-1 ALB APOA1 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism SLC34A2 ABCA3 SFTPD SFTPB CSF2RB CSF2RA SFTPC NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling PTPN11 MAPK1 MAPK3 BRAF FRS2 PPP2R1A PPP2CB;PPP2CA RPS27A FGF1 UBB;UBC CBL FGF2 FGF3 FGF4 FGF6 ANOS1-1 FGF9 FGF20 FGF23 FGF22 UBA52 MKNK1 SPRY2 FGF10 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CDKN1A RPS27A CDKN1B UBB;UBC ADRM1 PSMA2-1 CCND1 SEM1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 CCNE2 CDK4 CCNE1 CDK2 PTK6 CKS1B CCNA2-1 CCNA1 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling MC4R EDNRB RPS6KA1 EDN1 EDN3 PDE1C PDE1B PDE1A GRK2 PRKCD PLA2G4A MC3R POMC MC1R MC5R SRC CGA TSHB VAV3 C5AR1 NRAS MAPK1 VAV2 NPY HRAS MAPK3 ROCK1 ROCK2 GRK3 SOS1 OPRM1 OPRK1 ARRB1 ARRB2 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE PPP3CA DGKZ PPP3CB DGKQ DAGLB RASGRP1 DGKK PPP3R1 DGKI DGKH RXFP4 RLN3 CALM3;CALM1 RLN2;RLN1 INSL3 RXFP1 INSL5 APP RXFP2 RXFP3 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 CDK5 ARHGEF12 ARHGEF17 RHOB ARHGEF3 ARHGEF1 ARHGEF2 ARHGEF25 ECT2 GLP1R VIPR1 VIPR2 SCT NET1 ADM PTH1R GNGT1 ADRA1D ADRA1B ADRA1A ARHGEF40 PLEKHG2 ARHGEF15 GLP2R PLEKHG5 ARHGEF19 PTH2R RHOC TIAM2 ARHGEF4 ARHGEF7 GNAS-1 NGEF GIP ADCYAP1 ARHGEF6 FGD1 FGD2 CRH FGD3 IAPP CALCA GNA13 FGD4 ADCYAP1R1 TBXA2R RAMP2 CALCRL GNA12 RAMP3 ARHGEF33 GIPR ARHGEF37 PTH ARHGEF39 ARHGEF38 PLXNB1 CRHR1 PTHLH GHRHR GNG10 CALCR GNG2 GNG5 GNG4 GNG8 ABR CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CALCB;CALCA HTR2B GCGR ADRB1 ADRB2 HTR2A HTR4 SCTR HRH1 HTR6 HTR7 GCG HRH2 GNG13 HRH4 DRD1 GNB2 ADM2 DRD3 GHRH DRD4 GNB1 DRD5 GNB4 TAAR8 GNB3 HTR1E GNB5 HTR1F VIP TAAR9 RAMP1 TAAR6 HTR1D TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRB3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CYSLTR1 AHCYL1 CYSLTR2 GNAT3 C3AR1 ADCY9 PRKACA-1 PRKAR1B PRKACB-1 BTK GNAZ PRKAR2B CAMK2B CAMK2D CAMK2A ITPR1 ITPR2 ITPR3 CAMK2G PPP2R1B ADORA2B PPP2R1A ADCY4 GNAI3 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 CENPS-CORT;CORT;CENPS RPS6KA3 GNAI2 ADCY5 RPS6KA2 PPP3CC PPP2CB;PPP2CA CXCL8 PPP2R5D PLCB4 MAPK7 TIAM1 PRKCG OXTR AVPR1B AVPR2 AVP AVPR1A GNAL OXT-1 NBEA RASGRF2 CAMKK1 CAMKK2 CCL13;CCL2 C5 C3-1 GABBR2 GABBR1 AKT2 AKT3 AKT1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 RHO GNAT1 SAA2;SAA1 VAV1 PAK1 CAMK4 MCHR1 PIK3CG GNAT2 PRKCA PLCB3 PDPK1 PLCB1 PLCB2 PIK3CA CDC42 PRKAR1A SSTR3 EGFR RGS9 RGS6 RGS7 CCR5 GNA14 GNA15 GNA11 PDYN AGTR2 FPR1 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 GPR37 CXCL2;CXCL3;CXCL1-1 RGR GNAQ ARHGEF18 RHOA RGS11 CCL4L2;CCL4L1;CCL4 CCL19 OPN1SW GPHA2 CCL16 CCL25 P2RY12 P2RY13 CCL21 CX3CR1 CCL20 ITGB1 P2RY14 GPR55 CCL28 CCL27 TRIO GPHB5 ITSN1 CXCL13 ADORA3 ADORA1 LHCGR MTNR1A PREX1 MTNR1B PSAP CXCL10 MCF2L CXCL11 ADORA2A ITGA5 P2RY4 CCL5 ARHGEF16 CCL1 APLN RRH TAS2R3-1 CXCL5;CXCL6 PTGDR TAS2R16 GPR37L1 TAS2R40 ARHGEF5 TAS2R41 TAS2R42 SST LHB MC2R ARHGEF26 PENK PPY CCR10 KALRN CCR1 PPBP TAS2R39 HCAR2;HCAR3 ACKR3-2 PTGDR2 NPY4R2;NPY4R CX3CL1 MCF2 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 KPNA2 CCR2 OXGR1 FSHB GPBAR1 GAL FSHR OPRD1 PTGER4 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PPP1CA NPY2R NPY1R PRH1-TAS2R14;TAS2R14-3 APLNR SUCNR1 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL9 TAS2R8 GRM3 MGLL HEBP1 GRM2 GRM4 GRM7 GRM6 ANXA1 GPER1 GRM8 TAS2R1 TAS2R4 PTGIR NPY5R SSTR1 SSTR2 SSTR4 GPR176 SSTR5 GPR15 CRHR2 OPRL1 GPR27 CNR2 GPR25 CNR1 GPR20 TAS1R2 GPR32 S1PR3 GPR45 TAS1R1 GPR150 S1PR2 PRKAR2A GPR83 S1PR5 GPR84 S1PR4 PDE2A TAS1R3 PPP1R1B TSHR CXCL12 PDE3A RGS8 PDE8B PDE8A PCP2 GRK6 PDE4D-1 GPSM1 GPSM2 PDE4A GPSM3 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A SOS2 RGS10 CXCR4 RGS12 PDE7B PDE7A NPFFR2 NPFFR1 RGSL1 GRPR EDNRA PROK2 PROK1 PRKCB UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 HBEGF NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 GAST FFAR2 FFAR1 GPR39 EDN2 TACR2 TRPC7 TACR3 TACR1 F2 TRPC6 TRPC3 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 ADRA2C GPR4 ADRA2B AGT ADRA2A F2RL1 F2RL2 F2RL3 PDE3B GPR68 GPR65 PMCH RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR F2R LTB4R2 NTS PF4;PF4V1-1 MCHR2 KNG1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR MMP3 RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK HCRTR2 HCRTR1 KISS1 FFAR3;GPR42 PRKCQ RASGRP2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine PGM3 GFPT2 GNPNAT1 GFPT1 NAGK AMDHD2 RENBP UAP1 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis POLD2 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 UBA7 TRIM25 UBA52 POLK POLE POLH RFC5 USP10 RFC3 RFC4 PCLAF RFC1 POLI USP43 RFC2 REV1 RPS27A UBB;UBC ISG15 UBE2L6 PCNA POLD3 POLD4 POLD1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation SALL4 CSNK2A1;CSNK2A3 AGO3;AGO1 HDAC5 HDAC2 SUZ12 HDAC1 HDAC7 MTA1 PML MTA3 SNAI2 NEDD4 SNAI1 EGR1 KDM1A MAPK1 MAPK3 MLST8 EED RCOR1 ATN1 MAF1 RBBP4 RBBP7 ATF2 TNRC6A-1 PREX2 CHD4 TRIM27 CHD3 NR2E1 MTOR USP13 TNRC6C TNKS HDAC3 TNKS2 WWP2 CBX8 RNF146 CBX6 FRK TNRC6B PHC2 OTUD3 PHC1 CBX4 MTA2 CBX2 MKRN1 REST PHC3 BMI1 RPTOR RING1 RNF2 RRAGA RRAGC RRAGB RRAGD PSMD8 PSMD6 PSMD7 PSMD2 SLC38A9 PSMD3 PSMD1 MBD3 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 GATAD2B PSMC2-1 GATAD2A PSMA5 JUN PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 TP53 SEM1 MECOM PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PPARG AKT2 AKT3 AKT1 USP7 CSNK2A2 CSNK2B PTEN XIAP MOV10 AGO4 AGO2 EZH2 STUB1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking WASL DNM2 NOSTRIN NOS3 CAV1 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones TADA2B HCFC1 TAF10 CLOCK SAP130 EPC1 PAX3 JADE1 JADE3 JADE2 ING4 ING3 H2BC5 H2AC16;H2AC11 VPS72 SUPT20H MSL2 MORF4L1-2 H2BC1 SUPT7L SUPT3H MSL1 ING5 TAF6L RUVBL2 KAT6B MORF4L2 HAT1 ENY2 TAF5L H2AC4 BRD8 DMAP1 KAT8 BRD1 ELP1 ELP2 ELP3 KAT2B ELP4 KAT2A MSL3-1 ELP5 BRPF3-1 ELP6 MRGBP MBIP TADA1 DR1 TADA2A ZZZ3 YEATS2 TADA3 SGF29 RUVBL1 KANSL1 TRRAP KANSL2 KANSL3 H2BC21 WDR5 ACTB-1 MEAF6 YEATS4 ATXN7 BRPF1 MCRS1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 RBBP7 KAT6A ATF2 USP22 EP400 PHF20 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 OGT-1 EP300 H2AC20 ACTL6A NCOA1 H2BC18 NCOA2 TAF9 CREBBP TAF12 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation EP300 TP53 ING2 PIP4P1 PIN1 MAP2K6 PIP4K2A PIP4K2B SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM SLC34A2 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions PTGS1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1-1 TGFBR2 TGFB1 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation EEF1A1 VCP-1 YWHAE HSP90AA1 RPA1 RPA2 PTGES3-1 RPA3 HDAC6 HSP90AB1 HSF1 HSBP1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism SIN3A LBR GLS2 TXNRD1 INS;INS-IGF2 COX7A2L-1 ARNT2 COX7A2 RAPGEF3 RAPGEF4 CTSV;CTSL IQGAP1 MAOB HPGD LTA4H CYP2D6;LOC107987479;LOC107987478-1 CYP2J2-1 CYP2C9;CYP2C19 CYP2C18-1 AHR CYP2W1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP2F1 ABCG2 HMOX2 ACO1 ASNS SLC9A1 CA9 HIGD1A BCKDK BCKDHA BCKDHB DBT ABCB4 DLD ABCD4 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 LMBRD1 ABCB11 LDLRAP1 CUBN AMN APOA2 APOA4 APOA5 DTYMK NME4-1 AK1 ANGPTL4 AK2 CES3 GLRX AK5 AK6 AK7 AK8 LPL AK9 AK4-1 NUDT13 RRM1 PRKACB-1 CTPS2 NME3 CTPS1 LDLR DCTD NME6 GPIHBP1 CMPK1 DCTPP1 ABCA1 APOC3 NR1H3 APOC2 ALB IDH1 SLC35B3 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 ENO1 ENO2 ENO3 HS6ST1 ENO4 HS6ST2 NT5C AGXT2 HS6ST3 NDST2 NT5C1A NDST1 DPYS NDST4 DPYD NDST3 NT5M XYLB UPP1 GALM-2 UPB1 TYMP GLCE OMD TALDO1 PHKA1 CYP26A1 HSPG2 PHKA2 CYP26B1 PPP1R3C NHLRC1 RDH11 HS3ST3A1 SDC4 SDC2 SLC35D2 SDC3 GNS CHST11 CHST12 CHST15 ST3GAL6 PLD3 CHST13 CHST14 B4GALNT2 PCK2 DERA EXT1 EXT2 B4GAT1 SDC1 FUT6;FUT5;FUT3 PYGB GBE1 AIP STAB2 AKR1B1 PYGM PYGL KHK GYS2 GYS1 B3GALT2 HYAL2 B3GALT1 MANBA CHST6 TPI1 CHST7 PGAM1 GAA PGAM2 CYB5A SLC23A2 AKR1A1 PGM2L1 CYB5R3 SLC23A1 B3GNT7 B3GNT4 FAM20B B3GNT2 CHST1 ALDOC ALDOB TKT ALDOA SPAM1 CHST2 CD44 AGL-1 CHST3 PAPSS2 B3GNT5 PAPSS1 EXTL2 GPC1 HAS1 SLC17A5 GPC3 HAS3 HAS2 GPC2 GPC5 GPC4 EXTL3 GPC6 GLYCTK LYVE1 AGRN FMOD CHPF NAGLU CHP1 SLC26A11 GYG2 GYG1 EPM2A CSGALNACT1 CSGALNACT2 KERA PGD VDAC1 SHPK RPE;RPEL1 PFKFB2 PFKFB1 SLC26A2 PI4K2B CEMIP MTMR2 PFKFB4 SLC26A1 SACM1L PI4KA PFKFB3 HMMR SBF1 FUT2 FUT1 FUT4 TKFC FUT7 FUT9 DSEL GCKR SLC37A1 B3GALT4 B3GALT6 PHKB B3GALT5 G6PC2 G6PC3 MAN2B2 UST OGN CRYL1 MAN2B1 HPSE GALK1 B4GALT2 B4GALT3 B4GALT1 ADPGK SLC2A1 HK2 SGSH HK1 HS2ST1 HK3 GAPDH-1 DSE PGM2 MAN2C1 PGLS SLC37A4 PGM1 HS3ST3B1 CHPF2 DCXR SORD BPGM HKDC1 ALDH1A1 PXYLP1 SLC25A17 LALBA CYP11A1 B4GALT6 B4GALT7 FBP1 RBKS B4GALT4 FBP2 B4GALT5 ST6GALNAC6 PRPS2 PRPS1 RAB14 GALT PRELP ACAN UGP2 PHKG1 PHKG2 CHSY3 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 HS3ST4 PITPNB HS3ST1 HS3ST2 RPIA GALNS PFKL GALE PC GNPDA1 CHSY1-1 GNPDA2 PFKM PFKP AOC1 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 HNMT FTCD ADH4 PTGIS TBXAS1 ADH1C;ADH1B;ADH1A CYP8B1 ACSS2 STARD3 ALDH2 ALDH1B1 STARD4 STARD6 ACSS1 ADH5 STARD3NL STAR TSPO UCP1 ELOVL3 CIDEA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP-1 ADA PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 PARP10 PRKG2 THRAP3 PRKCA FAM120B PLCB3 PLCB1 PLCB2 MAOA PRKAR1A ALDH4A1 PRODH2 PRODH;LOC102724788 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 HSD17B10 TPH1 OXA1L MRPS36 CACNA1C INPP5E SLCO1A2 WDR26 GLO1 GPT PDHB RMND5B LDHB LDHA MAEA RMND5A PDPR NDUFS3 MPC1 MPC2 PDK4 MPC1L PDK3 NEK1 ME3 DLAT ME2 PDK2 SHMT2 PDK1 PLD1 PDHX FAHD1 PDHA1 SIRT4 ARMC8 PDP1 MKLN1 LDHA;LDHC GID4 NDUFA5 PDP2 GID8 LDHAL6B LETM1 VAPB MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 TTR FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 PLIN3 PNPLA4 PNPLA5 PLIN1 PRSS3;PRSS2;PRSS1 LPIN1 LPIN2 LPIN3 MGLL CES1 PRKAR2A AKAP5 MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 INPP4A RUFY1 INPP4B PI4K2A VAC14 MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 ST6GALNAC5 GDPD3 GDPD5 MTMR6 NEU2 MTMR7 NEU3 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B NEU1 PLEKHA1 PNPLA7 ST3GAL5 PLEKHA2 ST8SIA5 PLEKHA5 TPTE;TPTE2 CTSA PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 FIG4 PIKFYVE PNPLA6 SRD5A3 PI4KB IPPK NUDT11;NUDT10-1 PPIP5K1 PPIP5K2 NUDT4;NUDT4B IP6K1 NUDT3 IP6K3 PNMT DDC TH DBH ARF1 STXBP1 M6PR DNM2 N6AMT1 MTRR AHCY NNMT GSTO1 MTR-1 MAT1A MAT2B COMT TRMT112 AS3MT MAT2A ADRA2C ADRA2A PIK3R4 GPX4 PIK3C3 ALOX12B ALOXE3 ABCC2 CKB ACBD5-1 ECI1 ACADM DECR1 ACSL1 PEX11A CIDEC ELOVL5 THRSP PNPLA2 CYP27A1 HSD3B7 AKR1D1 NR1H4 GSS CYP7B1 CYP7A1 TCN2 ALAS2 ALAS1 FECH COX15 UROS CPOX PPOX ALAD UROD HMBS OCRL COX10 SLC2A2 IDI2 MSMO1 SCD5 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 PLPP6 LTC4S GGT1 ENTPD1 ENTPD5 ADCY9 PRKAR1B DPEP2 DPEP1 LRAT PRKAR2B PLCG2 GGT5 RBP4 RBP2 RBP1 WASL RETSAT ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 GNAI2 ADCY5 NT5E INPPL1 PLD4 INPP5B PLCZ1 INPP5D INPP5J PLCE1 ITPK1 ITPKB ITPKC PLCB4 SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PM20D1 LRP1 LRP8 AWAT2 BCO2 BCO1 APOM ECSIT HSD17B1 CPT1A AGK LRP10 LRP12 AKR1B15;AKR1B10 CYP4V2 HACD1 TECR HSD17B3 HSD17B12 HACD3 HSD17B8 HACD2 HACD4 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 ACSL5 ACSL4 ACSL3 ELOVL7 TECRL ACSF3 ACLY PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 MBOAT7 MIOX ISYNA1 INPP1 INPP5A IMPA1 IMPA2 CSNK1G2 NOS3 NUDT16 NUDT5 ADPRM OSBPL1A FADS2 FADS1 SMIM4 UQCC3 UQCRB UQCC2 UQCC1 UQCR11 HSCB CYP2U1 UQCR10 BCS1L CYP1B1 TTC19 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LYRM4 UQCRQ LYRM7 UQCRC1 C12orf73 UQCRFS1 CYC1 UQCRC2 FXN NCOA3 PTGES3-1 SEPHS2 SECISBP2 EEFSEC SEPSECS PSTK INMT SARS1 GNMT SCLY STARD5 SLC10A1 SLC10A2 SLC51A SLC51B SLC27A5 GCH1 STARD7 COQ9 COQ7 RANBP9 COQ6 PTS COQ5 GCHFR HPDL COQ3 COQ2 SPR PDSS2 PSMD8 PDSS1 COQ8A PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 HADHA HADHB-1 ACADL GLUL ZDHHC21 PSMC2-1 PSMA5 PSMA6 PSMA3 CACNA2D2 PSMA4 PSMA1 SLC6A11 UBA52 ACHE PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 CDA GDA PSMB6 PSMB7 PFAS BCHE PSMB4 DNPH1 ATIC PSMB5 PPAT PSMB2 TK2 PSMB3 ADSL PSMB1 RPS27A ENTPD2 ENTPD3 UBB;UBC ENTPD4 ADRM1 CAD CACNB2 PSMA2-1 ENTPD6 CACNB3 SEM1 ENTPD7 ENTPD8 PSMC5 NT5C1B;NT5C1B-RDH14 CHAT PSMC6 UMPS CACNA1A GART PSMC3 NT5C2 PSMC4 CACNA1E PSMC1 PAICS UCKL1 DHODH TSPOAP1 UCK1 PUDP ACSM1 ADSS1 ACSM2A;ACSM2B PIAS4 ADSS2 ITPA UBE2I VDR NR1H2 RORA RXRA SUMO2 PPARG PPARA HMGCL ACSS3 BDH2 BDH1 OXCT1-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HMGCS2 HMGCLL1 ABHD10 UGT2A1 AACS ACAT1 UGT1A1;UGT1A6 UGDH OCA2 SLC45A2 SLC35D1 NAT1 DCT TYRP1 TYR PTGDS PCTP CEPT1 MFSD2A PCYT1B RTEL1 CHKB PCYT1A CHKA STARD10 ABHD3-2 PHOSPHO1 PEMT CHPT1 BRIP1 DDAH1 LYPLA1-1 CYGB POLD1 SMPD3 SMPD2 TTPA PLA2G4A PPA2 LGMN RAP1A SLC6A7 MAPKAPK2 RGL1 SLC25A15 CPS1 ARG1 ASL NAGS NMRAL1 ASS1 OTC SLC46A1 SMARCD3 HDAC3 CHD9 SMPD1 NPAS2 ARNTL HELZ2 CDS1 PITPNM1 PITPNM3 PITPNM2 TGS1 CDIPT EP300 HMOX1 ACOXL APOB PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 CYP19A1 NCOR1 TBL1XR1 CARM1 MECR CLOCK SLC25A27 UCP3 UCP2 SLC25A14 CALM3;CALM1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GLP1R GNGT1 TIAM2 GNAS-1 ACOT8 EHHADH-1 ACAA1-1 HSD17B4 DECR2 GNG10 ABCD1 SLC27A2 ACOT4 GNG2 GNG5 GNG4 GNG8 COX19 COX17 CHRM3 GCGR CS PXMP2 ACO2 TAZ GCG GNG13 GNB2 GNB1 GNB4 GNB3 TIMM21 GNB5 NDUFB8 IDH3G VAPA IDUA ACAD8 HIBADH HEXB NCAN ACADSB ALDH6A1 HEXA BGN BCAT1 SLC25A44 GLB1L3 BCAT2 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB NUP107 PPP1CC PPP2R1B PPP2R1A ETFB NUP160 BST1 NUP85 NDUFAB1 RPS27 PPP2CB;PPP2CA SEC13 NUP133 PPP2R5D NUP43 RANBP2 GLYATL3 ACSM5 GLYAT ACSM4 GCSH-3 NUP37 GOT1-1 GOT2-1 GADL1 APIP MRI1 CSAD ADO PTDSS2 TXN2 PTDSS1 CBS;CBSL ENOPH1 MPST TSTD1 BHMT2 FOLR2 SQOR FMO1 SUOX MTAP BHMT TST ADI1 ETHE1 CTH SLC25A10 CDO1 ERCC2 FDX1 FDXR AKT1 PRKAB2 CSNK2A2 CSNK2B TRIB3 PIK3R3 PIK3R2 PIK3R1 ABCC1 ALOX15 PIK3R6 CYP4B1 LPGAT1 PIK3R5 CPNE7 CYP4F22 CPNE6 ALOX5AP CPNE3 PTGR1-1 PCYT2 PISD PLA2G15 PGP PLA1A ABHD4 PGS1 PTPMT1 OSBPL8 OSBPL5 DGAT2L6 CRLS1 CDS2 PRKAG2 OSBPL10 PLAAT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 SELENOI MBOAT1 ETNPPL ETNK2 ETNK1 PNPLA3 B3GNT3 CSNK2A1;CSNK2A3 THEM4 MCEE PCCA MMAA PCCB MMUT FOLH1B;FOLH1 NAALAD2 NAT8L ASPA PIK3CD PIK3CB PIK3CG MMAB MMACHC MMADHC NRF1 PIK3CA PRKAA2 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 LCLAT1 AGPAT2 PLA2G2A-1 AGPAT3 AGPAT4 PLD2 GPAT4 CYP24A1 LIPI ACP6 LIPH AGPAT5-1 VKORC1L1 GPAT3 ST20-MTHFS;MTHFS ALDH1L1 JMJD7-PLA2G4B;PLA2G4B CTRB1;CTRB2 PLA2G10;LOC100652777 PLA2G2F NADSYN1 ALDH1L2 PLA2G2D PLA2G12A FLAD1 NUDT12 PLA2G2E SLC25A51;SLC25A52 MIGA2 SLC52A1;SLC52A2 MIGA1 SLC5A8 PLA2G4D BTD DDHD2 GPD1L-1 MTHFD1 MTHFD2 DDHD1 MTHFD2L GNPAT UBIAD1 LPCAT4 SHMT1 GPD1 HLCS PLA2R1 NMT2 PNPO SLC19A3 NADK SLC19A1 SLC19A2 ADIPOQ CBLIF SLC52A3 ADIPOR1 MTHFR ADIPOR2 TCN1 CD320 MOCS2 MOCS3 QPRT GPHN THTPA NADK2 SLC22A13 ASAH1 NMRK2 RFK NMRK1 NAPRT CD38 ACP5 AOX1 VKORC1 SLC25A19 PDXK NAXE MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 NMNAT1 SLC25A32 NAXD PPA1-1 LHPP PLIN2 NMT1 SPHK1 GAPDHS CYP2R1 TP53 TPH2 ASMT AANAT GBA GNA14 GNA15 GNA11 ECHS1 ACSM3 HADH ACADS GNAQ NUP205 NUP188 AAAS NUP42 CES2 NUP62 TPR PHYKPL NUP88 RAE1 NDC1 NUP214 RAB5A NUP210 NUP155 NUP153 CA1 NUP93 CA2 NUP50 CA4 POM121;POM121C NUP35 NUP54 SLC25A4 KCNG2 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 KCNC2 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 KCNB1 RPS8 SLC22A4 RPL23 RPS5 RPL22 RPS6 KCNS3 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 HSP90AA1 RPS3A ACADVL RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 PANK4 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 NUDT8 VNN2 PPCS PDZD11 FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT ISCA2 ISCA1 CMC1 PYURF SCO1 SUCLG2 SUCLG1 TMEM126B NDUFC2;NDUFC2-KCTD14 TRAP1 SURF1 NDUFAF6 GGT7 NDUFAF7 ACY3 NDUFAF4 GGT6 NDUFAF5 MGST3 NDUFAF2 MGST1 SFXN4 MGST2 NDUFAF3 AKR7A2 NDUFAF1 AKR7A3 NDUFS5-1 HCCS TMEM186 NNT RAB5IF ACAD9 COQ10B TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH DMAC2 PET117 TIMMDC1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT COQ10A-1 SDHC SDHD SDHA SDHB NDUFB10 NDUFB11 COX18 COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 IDH2 TMEM126A-1 HIGD2A COX20 FFAR1 ETFA TMEM223 IDH3B IDH3A COA5 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 ETFDH AGT NDUFB2 NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 SUCLA2 HGD TAT FAH HPD CYP46A1 CYP39A1 POR CYP27B1 SLC27A1 OGDH DLST MCCC2 MCCC1 PPM1K AUH IVD QARS1 HIBCH STS ARSA RARS1 SUMF2 SUMF1 MARS1 TPST2 TPST1 DARS1 LARS1 ARSL EEF1E1 ARSJ ARSK KARS1 ARSH ARSI IARS1 ARSG POMC AIMP1 AIMP2 EPRS1 CAV1 ARSD-1 DIO1 DIO3 TXNDC11 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 TPMT ABCC5 NME2 GMPS GSTM1;GSTM2-1 GSTA3;GSTA1 NME1 IMPDH1 GUK1 IMPDH2 HPRT1 GSTA3;GSTA5;GSTA1;GSTA2 NUDT15 XDH HSP90AB1 PIP5K1C DHRS7B SYNJ2 SIRT5 GLUD1;GLUD2 GC PIK3C2A SRD5A2 SRD5A1 LRP2 CYP17A1 SLC25A18 MDH1 MDH2 STK11 SLC25A12 SLC25A22 SLC25A11 SLC25A13 RIDA SDS PGK1 SDSL PECR CROT ACY1;ABHD14A-ACY1 SCP2 SNAP25 NUDT19 GSTK1 PIPOX STX1A BAAT VAMP2 ACOX2 AGPS TM7SF2 ACOX3 HMGCS1-1 AGXT GGPS1 ELOVL6 PAOX LSS PHYH-4 SREBF2 DDO MTF1 ALDH3B2;ALDH3B1 HAO1 HACL1 MVD ACOT2;ACOT1 IDI1 SEC23A MVK EPHX2 SAR1B INSIG2 NUDT7 INSIG1 AMACR ACACB DAO ACACA CRAT PMVK SC5D SCAP FDFT1 FDPS MBTPS1 SEC24B SEC24A MED19 NFYB MED18 NFYC CYP51A1 MED11 SEC24D-1 MED29 SQLE MED22 GPAM MED21 SP1 SCD NFYA-1 DHCR7 SEC24C MBTPS2 GM2A MED13L GLIPR1 CYCS-1 ORMDL3 PTGES2 SLC22A5 ATP5MC2 DEGS1 ATP5MC3 MED9 ATP5MC1 ATP5F1A ATP5F1B CDK19 ATP5MJ ATP5MG ATP5ME DMAC2L GLA HSPA9 ATP5PF ATP5PD MED28-1 ATP5PB ATP5F1C ATP5F1D ATP5PO AHCYL1 PRKACA-1 ITPR1 ACBD4 HSD11B1 ITPR2 HSD11B2 SERPINA6 DMGDH ITPR3 CHDH SARDH ALDH7A1 FMO2 FMO3 KCNJ11 CERK GBA2 OSBP MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 UGCG UGT8 SGPL1 B4GALNT1 KDSR B3GALNT1 ACER2 ACER1 FA2H ACER3 DEGS2 GAL3ST1 SMPD4 SPTLC1 ALOX12 SPTLC3 A4GALT SULT1C2 CERS3 TXN CERS4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CERS5 BPNT2-1 CERS6 PODXL2 SPHK2 ABHD14B CERS1 BPNT1 CERS2 SULT6B1 SAMD8 SULT2A1-4 SULT4A1 ASAH2 SGMS1 SULT1B1-1 PPM1L SGMS2 ORMDL2 SPTSSB ORMDL1 SGPP2 SGPP1 GALC CH25H OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 HSD17B11 HSD17B2 MARCKS IPMK MINPP1 SYT5 MLX GLDC HYKK TDO2 HOGA1 CKMT1A;CKMT1B PLCG1 PTPN13 IDO2 IDO1 GCDH OAZ1 ACMSD AFMID RIMKLA RIMKLB PYCR1 PYCR2 CD36 PYCR3 SLC6A8 KYAT3 PHGDH AASS ARG2 OAT HAAO ODC1 CKM AADAT BBOX1 AGMAT GATM SAT1 PSPH KMO SMS AZIN2 GRHPR SERINC1 SERINC3 SERINC2 SERINC5 SERINC4 SLC25A2 AMD1 AZIN1-2 DHTKD1 KYNU ALOX5 AMT PTGS2-2 ALDH9A1 SRM CKMT2 ABCC8 SRR SLC25A21 GCLC CRYM TMLHE PSAT1 GCLM ME1 ABCC3 GPX1 ALPG;ALPP;ALPI-1 BLVRB CLPS BLVRA GSTP1 NQO1 PNLIP ADHFE1 D2HGDH L2HGDH SLC3A2 SLC36A4 ACOT9 ACOT7 FAR1 FAR2 SLC6A12 MCAT PRXL2B SLC7A5 PTGR2 PTGS1 G0S2 THEM5 FHL2 FAAH2 TNFRSF21 HSD17B13 AWAT1 SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 CPT1B PTGES ALOX15B ST3GAL4 ANKRD1 FITM1 FITM2 ST3GAL1 GRHL1 CBR1-1 ST3GAL2 ST3GAL3 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 ACSF2 CPT2 PON3 PON2 PON1 IP6K2 SCO2 CCNC-1 PPARGC1B SAMHD1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 SIRT3 MED23 RAB4A MED25 MED24 MED20 PPARD PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PNPLA8 MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 NOSTRIN TK1 CA3 DHFR2;DHFR CA7 TYMS CA6 BPHL CBR3 NOSIP AADAC SLC25A28 SLC25A37 GLRX5 AOC3 AOC2 CMBL MTARC2 MED30 MTARC1 CA12 NQO2 CA14 CA13 ALDH3A1 EPHX1 CA5B CA5A G6PC1 COX4I1 COX4I2 PTEN ARNT PSAP RRM2B NDUFA4 LHB APOE PCK1 COX7B COX7C COX8A SREBF1 COX8C COX5B COX5A RXRB COX6C GCK MED31-1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 CACNA1D GLS QDPR NAMPT IL4I1 PAH PIP4K2A PCBD1 PIP4K2B KYAT1 ASRGL1 GAMT MED8 MED4 MED6 MTMR4 MED7 GPI PIP4P1 NCOR2 RRM2-1 GSTT1 OPLAH GPS2 CNDP2 HPGDS ESD CHAC2 CHAC1 GSTM4 GSTM3 GSTO2 GSTT2B;GSTT2 GGCT GSTZ1 GSTA4 ABCB7 CIAO3 NUBP1 NUBP2 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B ESRRA CDK8 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion HEYL WT1 MPHOSPH8 H2AJ CSNK2A1;CSNK2A3 FOXQ1 PRKCSH AGO3;AGO1 TLE1 ZBTB33 ARHGAP32 SOX10 HDAC2 GANAB PKM SUZ12 H2BC5 HDAC1 CDH19 H2BC1 CTSS MOGS SMARCA4 MCRIP1 CTSB ANGPTL4 KLF4 PRDM8 BHLHE22 CDH8 H2AC4 CTNNA1 MYCN CDH24 RB1 TMEM258 HOXC8 SNAI2 FOXF1 SRC CTNND1 ADAM33 ADAM19 ILF3 CDH1 TWIST2 CDH11 SNAI1 CTNNB1 BANP OST4 EPS15 CBLL1 SEC11A OSTC SEC11C STT3A KDM1A MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 CANX DDOST POMT2 DAD1 SPCS3 SPCS2 ZNF217 SPCS1 POMT1 TFAP2A RBBP4 PIP5K1C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TNRC6A-1 MDM2-2 ANK3 TNRC6C CTSV;CTSL H2BC15;H2BC3;H2BC11;H2BC12 TGIF2 ARID1A TNRC6B FURIN PCSK6 ZEB1 SIRT1 KLF9 FOXJ2 STRAP FOXP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VCL PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ZEB2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 KMT5A PSMB2 PSMB3 TCF12 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 JUP PSMC5 DNM2 PSMC6 PSMC3 PSMC4 PSMC1 SP1 CTBP2 CTBP1 H2AC14 MYC CSNK2A2 CSNK2B RPN2 RPN1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FOXA2 MTBP MOV10 ZC3H12A AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 PCSK7 ZMYM2 RACK1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACADL MECR ECHS1 ACADVL ACSM3 HADH ACADS ACADM HADHA HADHB-1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis TPH2 TPH1 DDC ASMT AANAT DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c ALG6 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD VCAN AGRN CSPG5 CSPG4 SDC1 GPC1 HSPG2 GPC3 NCAN B3GAT3 BGN GPC2 SDC4 GPC5 SDC2 DCN GPC4 SDC3 BCAN GPC6 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 DOK1 PTK6 AKT1 UBA52 RPS27A ARAP1 UBB;UBC CBL ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat POLR2E POLR2F POLR2G POLR2H POLR2I NCBP2-1 POLR2L SUPT5H GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 NELFB NELFA NELFCD NELFE NCBP1 CTDP1 POLR2A SUPT4H1-1 POLR2B POLR2C POLR2D DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass POLD2 RPA1 RPA2 POLE4 NPLOC4 RCHY1 RPA3 POLE2 POLE3 UBA7 TRIM25 WDR48 UBA52 USP1 UBE2B UFD1 POLK DDB1 CUL4A DTL POLE VCP-1 RAD18 POLH CUL4B RFC5 USP10 RFC3 REV3L RFC4 PCLAF RFC1 POLI USP43 RFC2 REV1 MAD2L2 RPS27A SPRTN UBB;UBC ISG15 RBX1 UBE2L6 PCNA POLD3 POLD4 POLD1 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) NFATC1 TPST2 RUNX1 TBX21 STAT4 IL12RB2 CCL3L1;CCL3L3;CCL3;CCL18 TNF IFNG RUNX3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange RBBP8 ATRIP BARD1 XRCC2 XRCC3 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 SEM1 RHNO1 BLM RAD51AP1 WRN BRIP1 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol RPL34 BUD23 RPL10A RIOK1 RPL8 PELP1 RPL9 UTP15 RPL6 WDR36 RPL7 UTP11 TEX10 RPS15 DDX52 RPS14 UTP18 RPS17 SENP3 RPS16 GNL3 RPL18A C1D RPS19 NIP7 RPS18 RPL37A-1 HEATR1 DDX21 RPL35 NOL9 RPL38 NOC4L NOL6 EXOSC10 RPS11 PES1 BMS1 RPL39 RRP36 RPS10 RPP14 RPL15-1 DCAF13 RPS13 UTP6 RPS12 UTP4 RPS9 UTP3 RPL21 RIOK3 RPS7 KRR1 RPS8 WDR18 RPL23 WDR12 RPS5 BYSL RPL22 BOP1 RPS6 TSR1 RPSA MPHOSPH6 RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 CSNK1D RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 NOP58 UBA52 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 XRN2 EXOSC3 RPS27A EXOSC2 EXOSC1 NOP56 TPTEP2-CSNK1E;CSNK1E LTV1 RPP30 RRP1 FCF1 RRP9 FBL LOC102724159;PWP2 MTREX UTP14C;UTP14A RPP38 IMP3 WDR75 IMP4 FTSJ3 EBNA1BP2 NCL-1 RPP21 RPP25 UTP25 ISG20L2 SNU13 RRP7A EMG1 PDCD11 ERI1 DHX37 UTP20 NOP14 PNO1 RPP40 RCL1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 RBM28 DDX49 RPL4 DDX47 RPL30 WDR3 RPL3 WDR46 RPL32 WDR43 NOB1 RPL31 RIOK2 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions VPS18 TAB2 TAB1 ATG14 VPS11 JAK1 VPS16 RPS15 RPS14 RPS17 RPS16 NOD1 YWHAH NOD2 RPS19 RPS18 IRAK2 KPNA2 RPS11 RPS10 YWHAZ TRAF3 RPS13 IKBKE RPS12 RPS9 STAT1 RPS7 RPS8 TLR8 TLR7 RPS5 RPS6 RPSA CAV1 MBL2-1 MASP1 ISG15 LARP1-1 RPS25 RPS29 RPS20 IRF7 RPS21 RPS24 VPS41 NLRP3 RPS23 VPS45 YWHAB RPS4X STING1 NUP107 TYK2 IFNAR1 TOMM70 HSP90AA1 YWHAG IL17RC RPS3A IL17RA PDPK1 TLR1 TLR2 RPS27L RPS15A HSP90AB1 STAT2 RPS3 IRAK1 RPS2 SFN FAU NUP160 NUP85 PTPN11 YWHAQ PTPN6 RPS27 SEC13 NUP133 CREBBP BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG NUP43 IKBKB IFNB1-4 IKBKG RANBP2 MAP3K7 GJA1 CHUK YWHAE TUFM NUP37 SEC23A SAR1B RPS27A GEMIN2 SNRPD2 SNRPD1 TJP1 SNRPD3 SMN2;SMN1 GEMIN4 GEMIN5 SEC24B GEMIN6 SEC24A SNRPF GEMIN7 GEMIN8 TKFC SNRPB SEC24D-1 DDX20 SNRPE-2 SNRPG-2 VPS33A PATJ VPS33B SEC24C MPP5 CRB3 G3BP1 G3BP2 PIK3R4 TBK1 IRF3 DDX58 AKT2 NUP205 IFIH1 NUP188 RNF135 AKT3 SIKE1 AKT1 AAAS MAVS TRIM25 NUP42 NUP62 TPR B2M NUP88 PIK3C3 RAE1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NDC1 NUP214 SFTPD NUP210 NUP155 NUP153 NLRP12 NUP93 NUP50 IL17F POM121;POM121C IL17A NUP35 NUP54 RIPK2 TRAF6 UBE2V1 CNBP-1 UBE2N VPS39 TAB3 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM PLK1 B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 ERCC6L NUP107 ZWILCH BUB1B PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport GNB1 GNB4 GNB3 GNB5 AQP11 GNAS-1 ADCY4 PRKAR2A ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR1A ADCY5 GNG10 AQP6 AQP4 AQP5 GNG2 AQP2 GNG5 AQP3 GNG4 GNG8 RAB11A MIP AVPR2 AQP1 AVP PRKACA-1 ADCY9 PRKACB-1 PRKAR1B RAB11FIP2 MYO5B PRKAR2B AQP9 AQP8 GNGT1 GNG13 LOC100509620;LOC112267859;AQP7 GNB2 AQP10 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins SEMA5A POFUT2 SPON2 SEMA5B SPON1 THSD7B ADAMTSL3;ADAMTSL1 ADAMTSL1 ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON ADAMTS20 B3GLCT CFP THBS2 THBS1 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE TLR3 UNC93B1 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli GNB1 GNB4 GNB3 GNB5 FLT4 IKBKB SPP1 TLN1 IKBKG VCL CDH5 GJA1 CHUK CALM3;CALM1 CACNA2D1 RICTOR IKBKE STAT1 CAPNS1 RELA CAPNS2 CAPN2 PRKACA-1 ADCY9 PRKAR1B PRKACB-1 CACNB1 CACNA1H CACNB2 NFKB1 CACNB3 CTNNB1 NFKBIA PRKAR2B ADM PKN2 GNGT1 PIEZO1 GNA11 PRR5 ITGAV ANXA2 PTK2 PIK3CD PPP2R2A;PPP2R2D PIK3CB MLST8 TRPV4 PDPK1 GNAS-1 PPP2R1B PPP2R1A PIK3CA ADCY4 PRKAR2A GNAQ ADCY3 RAMP2 ADCY2 CALCRL ADCY1 ADCY8 ADCY7 PRKAR1A ADCY6 HSPG2 ADCY5 AKT1 YAP1-1 FYN GNG10 P2RX7 ITGB1 GNG2 GNG5 MAPKAP1 GNG4 MTOR KDR GNG8 PIK3R2 CACNG7 PPP2CB;PPP2CA NOS3 ABL1 ITGA5 P2RY2 MMP14 PANX1 PECAM1 ITGB3 PTPN1 GNG13 GNB2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency BTD INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes TXN RELA PYCARD PSTPIP1 TXNIP HSP90AB1 NFKB1 CASP1 MEFV HMOX1 NFKB2 AIM2 APP PANX1 NLRP1 NLRC4 NLRP3 BCL2 P2RX7 BCL2L1 SUGT1 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription MAMLD1 SNW1 NOTCH3 HES5 HEYL HEY1 FABP7 KAT2B KAT2A NOTCH1 MAML2 HEY2 HES1 MAML1 PLXND1 EP300 WWC1 DLGAP5 PTCRA PBX1 CREBBP STAT1 RBPJ RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins RHPN2 ROPN1;ROPN1B RHOA RHOC LIN7B RHOB RTKN TAX1BP3 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ATXN3 NPY NR3C1 SIN3A FBXO32 G6PC1 SMAD2;SMAD3 SMAD4 HDAC2 IGFBP1 AGRP ABCA6 SOD2 FOXO3 HDAC1 PCK1 TRIM63 POMC CAT RETN SREBF1 FOXO1-1 PLXNA4 PPARGC1A INS;INS-IGF2 GCK SIRT3 FOXO4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 H2AJ PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 H2BC5 PSMD12 PSMD11 PSMD14 H2BC1 PSMD13 PSMA7 TP73 PSMB6 PSMB7 PSMB4 H2AC4 PSMB5 PSMB2 PSMB3 TCF12 PSMB1 KMT2A RPS27A UBB;UBC ADRM1 TAL1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CCNH SPI1 H2BC21 LMO1 LMO2 H2AZ2;H2AZ1 CDK7 GATA3 GATA2 MNAT1 GATA1 H2AC14 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LDB1 CBFB RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ABL1 H2AC20 ITCH MYB H2AB2;H2AB3;H2AB1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NCOR1 PSENEN TBL1XR1 PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SKP1 HDAC5 HDAC2 UBA52 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 MIB2 CUL1 SNW1 JAG2 JAG1 ADAM10 HDAC10 DLL1 HDAC11 MIB1 DLL4 NEURL1B ADAM17 NCOR2 RPS27A NEURL1 KAT2B UBB;UBC KAT2A NOTCH1 RBX1 RBPJ HDAC4 MAMLD1 CCNC-1 MYC HDAC3 HEY1 MAML2 HEY2 HES1 MAML1 EP300 CDK8 CREBBP APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A BUB1B CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBA52 UBE2D1 ANAPC10 ANAPC11 CDC23 MAD2L1 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 NEK2 ANAPC1 ANAPC2 RPS27A UBB;UBC RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid PDK2 PDK1 PPARD PDHX PDHA1 RXRA RARA CRABP2 CRABP1 DHRS3 SDR16C5 CYP26A1 ALDH1A3 CYP26B1 ADH4 DHRS9 RARG ADH1C;ADH1B;ADH1A RDH11 ALDH1A2 RDH10 RDH5 RDH14 RDH13 ALDH8A1 DLD ALDH1A1 FABP5 DHRS4 PDHB RARB RXRB RXRG PDK4 PDK3 DLAT WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis AWAT1 AGPS FAR1 FAR2 DHRS7B GNPAT AWAT2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling MTMR4 STRAP PMEPA1 NEDD4L UCHL5 PPP1CA BAMBI PPP1CC TGFB1 RPS27A UBB;UBC XPO1 SMAD2;SMAD3 SMURF2 SMURF1 TGFBR1-1 SMAD7 TGFBR2 STUB1 PPP1R15A UBA52 USP15 PPP1CB ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers SMARCB1 H2AJ SMARCC1 SMARCC2 SF3B4 SF3B5 SF3B2 SF3B3 SMARCD1 HDAC2 SF3B6 SMARCD2 SF3B1 SF3A3 SF3A1 SF3A2 H2BC5 PHF5A PCK1 HDAC1 H2BC1 SMARCA2 SNRPN SMARCA4 SMARCE1 CHERP MTA1 MTA3 H2AC4 PBRM1 SNRPA1 CTNNB1 PUF60 SNRPB2 CHD1 H2BC21 WDR5 ARID2 H2AZ2;H2AZ1 BCL11A CTCF RBBP4 CBX1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CHD4 CHD3 CBX3-1 SMARCD3 H2BC15;H2BC3;H2BC11;H2BC12 CHD9 ARID1A ARID1B MTA2 CHD7 NR2C2 NKD2 FAM124B ZNF592 CHD5 IKZF1 EP300 IKZF2 IKZF3 SUPT16H PHF6 ZMYND8-1 ACTL6B ZNF827 ACTL6A ZNF687 TCF19 MBD2 NR2F2 CREBBP CDK2AP2 CHD2 CDK2AP1 ZNF532 SSRP1 MAFK NFE2L2 ADNP2 ADNP MBD3 GATAD2B GATAD2A AXIN2 IGF2 PHF10 BCL11B TCF12 SNRPD2 SNRPD1 SNRPD3 BRD7 SNRPF SNRPB SNRPE-2 SNRPG-2 CTR9 UBE2I PWWP2B WDR61 MBD3L1 RTF1 PWWP2A CDC73 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 LEO1 ACTB-1 DKK2 CHD6 SUMO1 G6PC1 H2AC14 PAF1 CHD8 NQO1 DHX15 MYOG MYOD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TCF4 FBP1 BICRAL BICRA BCL7A BRD9 DDX46 BCL7C DPF1 DDX42 H2AC20 BCL7B DPF2 RBM17 DPF3 H2AB2;H2AB3;H2AB1 SS18 SS18L1 SMNDC1 U2SURP ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation NAT1 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants ALK PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling HBEGF PIK3R1 EGFR PIK3CA ERBB2 GAB1 NRG2 NRG3 NRG4 EGF NRG1 EREG BTC ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen HBA2;HBA1 CYB5R2 CYB5R1 CYB5R4 CA1 CA2 CA4 RHAG HBD;HBB SLC4A1 CYB5RL AQP1 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis FUT2 FUT1 DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA PSIP1 BANF1 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination LRP6 ZNRF3 LGR6 LGR5 LGR4 RNF43 RSPO3 USP8 FZD5 RPS27A FZD4 UBB;UBC WNT3A FZD6 FZD8 RSPO2 RSPO1 UBA52 RSPO4 LRP5 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 NCOR1 TBL1XR1 AURKB PTPN4 HTT SIN3A LBR AGO3;AGO1 BDNF CALM3;CALM1 GRIN2B GAD1 HDAC2 FOXG1 GAD2 HDAC1 SOX2 DLL1 PRKACA-1 NCOR2 GRIN2A CAMK4 MET PVALB CAMK2B GPS2 CAMK2D CAMK2A GRIA2 TRPC3 RBFOX1 CAMK2G HIPK2 CRH GPRIN1 IRAK1 PPARG PTEN TNRC6A-1 DGCR8 FKBP5 TNRC6C HDAC3 OPRM1 TNRC6B MOV10 AGO4 AGO2 SGK1-1 OPRK1 PTPN1 GAMT MEF2C SST TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) SYT1 VAMP1 VAMP2 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP2R1 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines SAT1 PAOX DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 CTSS PSMD13 CTSB PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CTNNA1 PSMB2 PSMB3 SRC PSMB1 CTNND1 RPS27A UBB;UBC ADRM1 CDH1 PSMA2-1 SEM1 CTNNB1 JUP BANP PSMC5 DNM2 EPS15 PSMC6 CBLL1 PSMC3 PSMC4 PSMC1 MDM2-2 CTSV;CTSL MTBP RACK1 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle TP53 SLC25A15 CPS1 ARG2 ARG1 ASL SIRT5 NAGS NMRAL1 SLC25A2 ASS1 OTC ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus CNTN1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B DTX4 UBA52 MIB2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B NUMB ADAM17 RPS27A NEURL1 UBB;UBC NOTCH1 ITCH DNER DTX1 DTX2 ARRB1 DLK1 ARRB2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes MCPH1 H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 CDK1 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KMT5A RB1 H2AJ SET-1 H2AC20 NCAPH2 H2AC14 NCAPG2 H2AB2;H2AB3;H2AB1 SMC4 SMC2 NCAPD3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PLK1 H2BC5 H2BC1 CCNB1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration CBFB ITGBL1 AKT2 AKT3 AKT1 MMP13 ITGA5 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies HMGCL ACSS3 BDH2 BDH1 HMGCS2 HMGCLL1 AACS ACAT1 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H POLR2I POLR2L GTF2H1 TAF8 GTF2F1 TAF4B GTF2H3 TAF7 GTF2F2 TAF6 GTF2H4 TAF5 CDK7 TAF4 POLR2J;POLR2J2;POLR2J3 TAF3 ERCC3 TAF2 ERCC2 TAF1 MNAT1 GTF2B TAF7L TBP GTF2A1 GTF2A2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH TAF9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C TAF15 POLR2D TAF12 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs NUP107 NUP43 RANBP2 NUP205 NUP188 PSIP1 AAAS NUP42 NUP62 NUP160 TPR BANF1 NUP88 RAE1 KPNA1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA SNRPG-2 ZNF473 NCBP2-1 LSM10 SLBP LSM11 CPSF2-1 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T WDR33 NUDT21 PABPN1-1 CLP1 PCF11 PAPOLA SYMPK CPSF7 FIP1L1 CPSF4 SNRPD3 NCBP1 SNRPF SNRPB SNRPE-2 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2BC21 ERCC6 H2AZ2;H2AZ1 TTF1 H2AJ MBD3 EHMT2 H2AC14 GATAD2B GATAD2A HDAC2 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 RBBP7 HDAC1 H2BC1 CHD4 CHD3 CBX3-1 MTA1 H2BC15;H2BC3;H2BC11;H2BC12 MTA3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 MTA2 H2AC20 H2AB2;H2AB3;H2AB1 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase ADCY1 ADCY8 CALM3;CALM1 PRKAR2B PRKAR1A PRKACA-1 PRKAR2A PRKACB-1 PRKAR1B PRKX CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT NFATC2 NFATC1 CALM3;CALM1 FKBP1A PPP3CA PPP3CB PPIA PPP3R1 NFATC3 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) ATF5 NRF1 ESR1 CAT HTRA2 LONP1 DNAJA1-1 HSPA9 HSPD1 HSF1 HSPE1 DEFA6;DEFA4;DEFA5 AKT1 SOD2 FOXO3 SIRT3 HSPA1A;HSPA1B DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 CASP8 FADD TNFSF10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FAS FASLG TRAF2 RIPK1 TRADD ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling HBEGF NRG2 NRG3 NRG4 PTK6 EGFR EGF NRG1 EREG BTC ERBB2 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling JAK2 JAK1 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RAF1 SP100 CD44 PRKCD MT2A PML IFI30 ICAM1 TRIM29 TRIM26 TRIM14 TRIM10 IRF7 GBP6 CAMK2B TRIM8 CAMK2D TRIM6 CAMK2A HLA-DRA TRIM5 TRIM2 TRIM3 IFNGR1 IFNGR2 PTAFR SOCS3 MAPK1 GBP2;GBP3;GBP1 CAMK2G MAPK3 MID1 GBP5-1 VCAM1 PIAS1 IRF1 SUMO1 IRF3 CIITA HLA-DQB2;HLA-DQB1 OASL TRIM68 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 OAS1 IRF5 TRIM25 OAS3 FCGR1A SMAD7 IRF8 IRF6 SOCS1 B2M IRF2 IRF9 TRIM46 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E YBX1 PTPN11 TRIM45 TRIM35 TRIM38 TRIM31 PTPN6 IFNG NCAM1 HLA-DPB1-1 GBP7;GBP4 PTPN1 IRF4 TRIM21 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport KIF22 KIF26A PLA2G4A KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KIF6 KIF27 RINT1 KIF9 ARF4-1 KIFC2 KIFC1 KIFAP3 KIF16B KIF20B NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF5B KIF5A GALNT1 ARFGAP2 KIF3B KIF3A ARF5 TMED2-1 ARCN1 KIF3C DYNC1LI1 DYNC1LI2 ZW10 SEC22B KDELR2 RAB1A TMED10 AGPAT3 RAB1B KIF4B;KIF4A CAPZB KIF18A CAPZA1 ARFGAP1 CAPZA2 ACTR1A KIF2A KIF2C KIF2B PAFAH1B1 DYNC1I2 COPZ2 COPZ1 PLA2G6 DYNC1I1 DYNC1H1 CENPE DCTN2 DCTN3 GALNT2 NSF GBF1 RAB18 RAB3GAP2 ARF1 RAB3GAP1 TMED3 TMED7 TMED9 COPG2 COPG1 COPB2 COPA NAPA KDELR3 COPB1 NAPB DCTN1 COPE KDELR1 NAPG RAB6A RAB6B DCTN6 DCTN5 DCTN4 RACGAP1 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 KIF20A KLC1 KLC4 KLC3 ARFGAP3 KLC2 KIF11 KIF15 KIF23 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation NDC1 NUP85 UBE2I NUP37 NUP107 NUP155 NUP93 POM121;POM121C NUP43 NUP35 NUP54 KPNB1 AHCTF1 SUMO1 SEC13 NUP133 TNPO1 NUP205 NUP188 RANGAP1 NUP62 NUP160 RAN RCC1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis MAPK1 TRIM27 RNF213-2 MAPK3 CTSG GSK3A SFPQ-1 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism PDZD11 HLCS ACACB MCCC2 ACACA MCCC1 PC PCCA BTD PCCB SLC5A6 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB6 ABCB10 ABCB7 ABCB8 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN TNKS TNKS2 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste GNB1 GNB3 SCN2A SCN2B KCNJ2 TAS2R39 TAS1R2 SCNN1G TAS1R1 PLCB2 SCNN1D SCNN1B OTOP1 SCNN1A TAS1R3 SCN9A SCN1B GRM1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GNAT3 PRH1-TAS2R14;TAS2R14-3 CALHM1 SCN4B TAS2R7 TAS2R8 TRPM5 CALHM3 TAS2R3-1 TRPM4 GRM4 SCN3A TAS2R16 TAS2R40 GNG13 TAS2R41 TAS2R1 TAS2R4 ITPR3 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery RPS4X RPS15 RPS3A RPS14 RPS17 RPS16 RPS27L RPS19 RPS15A RPS18 RPS3 HNRNPA1-1 RPS2 RPS11 RPS10 RPS13 RPS12 FAU RPS9 RPS7 RPS8 RPS5 EEF1A1 RPS6 RPSA RPS27 RPS27A RPS25 RPS29 RPS20 RPS21 RPS24 RPS23 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly SMIM20 TIMM21 COX6A1 SURF1 COX6A2 SCO2 COX6B2 COX6B1 COX7A2 RAB5IF COQ10B TMEM177 COX15 COX4I1 PET117 COX4I2 HIGD1A TACO1 COQ10A-1 COX7B COX19 COX7C COX18 COX17 COX11 COX8A COX14 COX8C COA3 COX5B COX5A HIGD2A COX20 TMEM223 COX6C COA5 NDUFA4 CMC1 SCO1 COX7A2L-1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes RORC BHLHE40 RORA CRTC1 CLOCK NPAS2 ARNTL KMT2A PER2 TFEB PER1 CRY2 CRY1 RBM4;RBM4B DBP CIPC SIK1;SIK1B CREBBP NR1D1 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators CRP C1QB COLEC11 COLEC10 C1S C1R FCN2;FCN1 MBL2-1 MASP1 C1QC BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis B3GALT4 ST3GAL6 B3GALT5 B4GALNT2 FUT6;FUT5;FUT3 ST6GALNAC6 B3GALT2 FUT2 FUT1 B3GALT1 ST3GAL4 FUT4 FUT7 FUT9 ST3GAL3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence MCM5 MCM2 BRCA1 TERT LIG1 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions JAK2 TYK2 IL11 JAK1 CNTFR OSMR CNTF LIFR IL31 IL31RA OSM CTF1 LIF IL11RA CLCF1 IL6ST CRLF1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways PELP1 SIN3A LBR HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC7 PML HDAC10 HDAC11 TNF RUNX3 TNFRSF1A FCER2 SPARC CITED1 INS;INS-IGF2 PRMT1 NPY PDGFB STEAP3 ATP1B4 KCTD6 SMAD1 SMAD4 SMURF2 SMURF1 RAPGEF3 SMAD6 RAPGEF4 ESR2 SMAD7 NR4A1 VEGFB VEGFC VEGFD YBX1 NR2E1 CFL1 CASP2 AXIN1 OPRM1 RBL1 THBS1 ERBB2 HES1 OPRK1 ITGB3 PLG ARAF PEBP1 ARRB1 PHB AAMP BCAR1 IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 GRB7 RAF1 TLN1 KIF14 MAP3K11 STMN2 RND1 VCL STIP1 WDR6 PLXNA1 FAM83B ANKRD26;CCDC144A;LOC105375816 DST RRAS2 ALDH3A2 TMEM59 CCDC88A FAM135A VANGL2 UBXN11 CPD DLG5 PKP4 TFRC TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D HMOX2 ATP6V1C1 ATP6V1C2 ATP6V0A1 ATP6V1F ATP6V0E2;ATP6V0E1 TBK1 DTX4 EPO DBT DLD COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 COL6A5 COL9A2 AP2A1 AP2A2 AP2M1 MYLIP LIMK2 LIMK1 MYH14 MYH10 ANGPTL3 ABCG1 CETP PRKACB-1 AP2S1 ABCA1 APOC4 DNER NR1H3 TLE4 TLE2 AP2B1 DTX1 APOC2 DTX2 DLK1 APOC1 RNF31 OTUD7B P4HB SPATA2 TNFAIP3 SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 CRABP1 DHRS3 SDR16C5 CYP26A1 ALDH1A3 CYP26B1 DHRS9 RDH11 ALDH1A2 RDH10 RDH5 RDH14 RDH13 ALDH8A1 ST3GAL6 ARHGAP10 PPP3CC IL5RA CSF2RB CSF2RA IL5 IL3RA IL2RB GPC5 RAG2 RAG1 B4GALT1 GFRA1 GDNF ID4 ALDH1A1 SRMS ACVR1C ACVR1B ACVR2B CER1 SALL4 PPP1R14A PPP1R12A PPP1R12B ARHGAP39 SRGAP3 PTPRZ1 SRGAP2 SRGAP1 OPTN-1 IKBKE ADH4 ADH1C;ADH1B;ADH1A FLT3LG MTA1 ABCD3 MTA3 ABCG8 ABCG5 GSK3A EGR2 GNAT2 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 LEP PLCB2 NLK PDE6B PDE6A GNAO1 ALK PRKAR1A STRN SOX17 MMP2 POGLUT1 POFUT1 MFNG FLT4 MDK ACTA2 RFNG LINGO1 MAG OMG RTN4 NAB1 NAB2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID3 DNAL4 ID2-1 LYL1 F3 VGF ASCL1 CDK5R2 SOCS6 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ARHGEF18 CGN F11R PRKCZ RHOA PARD6A PARD3 OPN1SW RPS6KA5 ARL13B PDE6D ITGB1 MKNK1 CYFIP1 DOCK5 SPRY2 HGFAC DOCK4 ANKLE2 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L STBD1 ARHGDIB EMD TMPO PLEKHG3 PDHB ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 PDK4 DOCK2 DOCK1 ARHGEF5 PDK3 EPHA2 VAMP3 RAB7A DLAT GARRE1 PDK2 ARHGEF26 SHMT2 PDK1 PLD1 PDHX IQGAP2 KALRN PDHA1 ARHGAP21 LMAN1 STX5 YKT6 PAK4 NDUFA5 MCAM MCF2 ERBIN PDGFRB HSPE1 MPP7 TRAT1 NTRK3 KTN1 PIK3AP1 LETM1 VANGL1 PTPRU SH2B3 ARHGAP32 DIAPH3 SH2B2 VAPB CMA1 ESYT1 FER TEC FES GRAP PPP1CB PPP1CA FABP5 FABP6 FABP7 RANBP10 PLIN3 PLIN1 MGLL KIF5B KIF5A ITGAV PTK2 BUB1B-PAK6;PAK6 CRHR2 PFN1 INHBB FLRT3 PRKAR2A ABL2 CXCL12 NRP1 NCK2 NCK1 EVL PFN2-1 SOS2 CXCR4 PAK5 MYO9B MTMR1 PIP5K1A PIP5K1B EPOR ELK1 UHMK1 EREG BTC ACVRL1 BMP10 EPGN BMPR2 HBEGF AMHR2 NGFR SQSTM1 CHRDL1 FSTL1 AMH NOG GDF2 SMAD9 SMAD5 GREM2 CLTB ZFYVE16 BMPR1B BMPR1A DNM2 PTPRS PTPRF MTR-1 ADRA2C ADRA2B ADRA2A KLB IRS1 PDE3B PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 TNFAIP1 RND3 CKB ITGA3 SEMA4F ITGA2 CKAP4 NISCH KCTD13 CDC14A IL6R RBCK1 RHOU IL33 IL1RL1 PTK2B KLHL12 HECW1 WDR91 ANKFY1 SH3RF1 WDR81 CDC42SE2 ARHGAP9 OSBPL11 LRRC41 LRRC1 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 KCTD3-1 FGD5 CHN2 CHN1 FARP1 DEF6 WDR11 NEDD4 SHKBP1 FILIP1 GOPC UHRF1BP1L FAM13B FAM13A RALGAPA1 TEX2 FAM91A1 ARMCX3 DDRGK1 NSFL1C ZNF512B ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 SH3BP1 WHAMM GOLGA3 BAIAP2L2 SPATA13 TMEM87A FAF2 AKAP12 HINT2 SH3PXD2A CCDC115 RNF41 RALBP1-1 RHOH RHOF RHOD CUL5 RHOV ACBD5-1 EMC3 PRAG1 ARHGAP44 SYDE2 DOCK11 BASP1 ARHGAP45 ARHGAP19 ARHGAP18 SOCS1 TOR1AIP1 ARHGAP12 ARHGAP22 ARHGAP20 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP31 DIAPH2 DNMBP ARHGAP30 DOCK6 MKRN1 DOCK9 RND2 ARAP1 ALS2 PEAK1 CCDC187 MOSPD2 ARHGAP11A-1 ADD3 FAM169A FMNL1 FMNL2 GPNMB LRRK2 VHL HGF FGFBP1 FGFBP3 CTBP2 CTBP1 NCKAP1 DUSP10 DUSP5 WASF1-1 DUSP2 NCF1 DUSP1 NCF2 SNAP23 PAQR3 DUSP8 NCF4 ARHGAP6 DUSP9 DOCK10 PTPN3 SYDE1 ARHGAP42 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 ARAP3 CYBB OCRL CYBA BCR PRICKLE1 AMIGO2 NOXO1 ARHGAP17 ARHGAP15 ABR RACGAP1 SLITRK3 NHS SLITRK5 NCKAP1L WASF2 GIT2 BAIAP2 ARHGAP26 ABI2 TAOK3 ABI1 NOXA1 NOX3 NOX1 FERMT2 C1QBP DNMT1 PTPRA PDGFRA PSENEN PSEN2 PSEN1 APH1A NCSTN ARTN APH1B GFRA3 HES5 HEYL GFRA2 GFRA4 ELMO1 NRTN DOK1 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW PSPN CYFIP2 WIPF1 WIPF2 WIPF3 CYSLTR1 CYSLTR2 GNAT3 C3AR1 ADCY9 PRKAR1B BTK GNAZ NCKIPSD PRKAR2B DVL1 PLCG2 DVL2 DVL3 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1B ARPC1A WASL ACTR2 SYK ADORA2B ADCY4 GNAI3 WAS ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 GNAI2 ADCY5 WASF3 PREX2 TRIM27 USP13 TNKS TNKS2 WWP2 RNF146 FRK OTUD3 IL2RG PLCB4 PRKCG LIN7B GNAL NBEA GABRB3 GABRB2 GABRB1 RASGRF2 RASGRF1 GABRG3;GABRG2 NRG1 CAMKK1 CAMKK2 GABRQ GABRA1 GABBR2 GABBR1 PRKCI RIPK2 MYD88 RHO GNAT1 ATF1 SAA2;SAA1 DUSP4 MEF2A DUSP3 IRAK4 VRK3 DUSP6 DUSP7 ESRP1 TRAK1 IFT172 CCP110 CEP97 DYNC2H1 RPGRIP1L IFT88 MCHR1 KIF3A TTC21B IFT122 MKS1 IFT52 IFT57 IFT140 SSTR3 WDR35 OFD1-1 WDR19 FSTL3 NOTUM TRRAP SOX3 FRAT2 SOX6 SOX7 SOX4 RNF43 RYK-1 CTNNBIP1 SOX13 DKK1 DKK2 DKK4 PYGO1 PYGO2 SFRP1 RHOBTB3 SFRP2 CSNK1G2 BCL9L BCL9 CCDC88C CHD8 USP34 CBY1 RSPO2 SOST RSPO1 RSPO4 KREMEN1 KREMEN2 LRP5 LRP6 ZNRF3 RAB6A WIF1 SRY LGR6 LGR5 LGR4 SHB NOS3 RAB9A RAB9B KLC1 KLC4 KLC3 KLC2 TLE5 FLNA STAT5A STAT5B GRB2 FOXA1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD NCOA3 GPR176 GPR15 NR5A2 GPR27 TFF1 GPR25 KANK1 GPR20 PTGES3-1 GPR32 CXXC5 GPR45 TFF3-1 KDM4B GPR150 USF2 GPR83 USF1 GPR84 ZNF217 PDE2A EBAG9 PPP1R1B NRP2 PDE3A RGS8 PDE8B PDE8A PCP2 GRK6 PDE4D-1 GPSM1 GPSM2 PDE4A GPSM3 SPTAN1 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 SPTB PDE7B DNM1 PDE7A DNM3 NUMB SPTBN4 SPTBN5 SPTA1 NCAM1 SPTBN1 SPTBN2 SCAI RANBP9 CNTN1 PSMD8 IKBKB PSMD6 PSMD7 SIRT6 ELF3 PSMD2 FLRT2 PSMD3 FLRT1 PSMD1 IKBKG TAX1BP3 BTRC MAP3K7 NF2 ROPN1;ROPN1B SKP1 PRC1 CHUK PRKCB ZDHHC7 CRABP2 ZDHHC21 PSMC2-1 PPID PSMA5 CAV2 PSMA6 PSMA3 MMP7 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RUVBL1 HDAC4 NR1H2 NR3C1 ESR1 AR RXRA RARA PPARG PGR KAT5 CHEK1 FLT1 LYPLA1-1 SPPL2B SPPL2A SMPD3 SMPD2 CLIP3 TAX1BP1 NSMAF OTULIN USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ABHD17B ABHD17A RCE1 PDE1C PDE1B PDE1A GRK2 PRKCD PLA2G4A PLK1 UBE2D1 CDK1 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 GRB10 PGF HGS INSR CTNNB1 STAM2 MET EPS15 SH3GL2 SH3GL1 SHC2 SHC3 FST RALB STAT6 FOXH1 YWHAB DRAP1 CRKL NRAS RAP1A MAP2K2;MAP2K1 MAPK1 RALGDS HRAS MAPK3 NTRK1 KIDINS220 BRAF FRS2 TMED2-1 MAPK14 RALA-1 NGF ADAM12 MAPK12 MAPK13 IER3 MAPK11 PHLPP2 RIT1 PHLPP1 ATN1 RIT2 MAPKAPK3 MAF1 RPS6KB2 MAPKAPK2 RAPGEF1 WDR83 RGL3 SOS1 CRK RGL1 RGL2 SHC1-1 PEA15 IL17RD MRAS RAPGEF2 SHOC2 SEPTIN7 CDC14B SCFD1 RASGEF1A ATF2 ETV4 IGF2BP1 MAPK6 MAPK4 ANGPT1 TEK HDAC3 PGRMC2 XPO1 NRIP1 EP300 ANOS1-1 MEF2D NCOA1 MED1 NCOA2 MEF2C CREBBP DGKG DGKE NCOR1 DAGLA DGKD TBL1XR1 CARM1 DGKB DGKA ABHD6 ABHD12 MATK PRKCH PPP3CA PRKCE PPP3CB DGKZ DGKQ WNT5B RASGRP1 DAGLB ROR1 RASGRP3 DGKK ROR2 PPP3R1 DGKI DGKH FGFRL1 NFATC1 RXFP4 CALM3;CALM1 RLN3 FKBP1A RLN2;RLN1 YWHAE INSL3 RXFP1 INSL5 APP JUN RXFP2 FASLG RXFP3 CDC25C ACTC1;ACTG2 RTKN SOWAHC FOXO3 ARHGEF10L AKAP13 LMNB1 STK10 SLK ARHGEF11 BCL2L11 ARHGEF10 ARHGEF12 CDK5 STARD8 ARHGEF17 CIT RHOB DAAM1 ARHGEF3 CDK5R1 ARHGEF1 ARHGEF2 ARHGEF25 PKN3 ARHGEF28 IQGAP3 STOM RHPN2 NOTCH1 ECT2 RBX1 STARD13 GLP1R JUP VIPR1 WNT2B CAVIN1 PCDH7 VIPR2 SCT MYO9A NET1 IHH ANLN ADM DIAPH1 FZD10 PTH1R DLC1 PKN2 ADGRE1 PKN1 GNGT1 CRHBP ADRA1D SHH ADRA1B UCN3 ADRA1A ADGRE5 ARHGEF40 ADGRE3 PLEKHG2 GLP2R ARHGEF15 PLEKHG5 WNT5A WNT9B ARHGEF19 PTH2R RHOC WNT9A TIAM2 ARHGEF4 WNT16 ARHGEF7 GNAS-1 GIP NGEF ARHGEF6 ADCYAP1 SMO FGD1 FGD2 CRH FGD3 IAPP GNA13 CALCA ADCYAP1R1 FGD4 RAMP2 TBXA2R GNA12 CALCRL RAMP3 ARHGEF33 GIPR ARHGEF37 PTH ARHGEF39 DHH ARHGEF38 WNT8A PLXNB1 WNT8B CRHR1 PTHLH GHRHR WNT6 GNG10 WNT11 CALCR GNG2 GNG5 GNG4 KDR GNG8 WNT1 WNT2 PTK6 CD55 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 CHRM2 FZD4 CHRM3 WNT3A CHRM1 CHRM4 PTCH1 CALCB;CALCA CHRM5 HTR2B GCGR WNT7B ADRB1 FZD7 ADRB2 HTR2A FZD6 HTR4 PTCH2 SCTR HRH1 HTR6 FZD9 HTR7 FZD8 WNT7A HRH3 GCG HRH2 HRH4 GNG13 GNB2 DRD1 ADM2 DRD2 DRD3 GHRH GNB1 DRD4 GNB4 DRD5 GNB3 TAAR8 HTR1E GNB5 HTR1F VIP TAAR9 RAMP1 TAAR6 SPRED3 HTR1D SPRED2 HTR1A RASA4;RASA4B TAAR5 SPRED1 SYNGAP1 HTR1B TAAR2 RASA3 HTR5A RASA1 TAAR1 RASA2 GPR143 CUL3 RASAL1 ADRB3 RASAL2 RASAL3 DAB2IP NF1 KBTBD7 PPP5C KDM4A CTNNA1 CDKN1A RHOT1 CDKN1B CCND3 SNAI1 PLXND1 CCND1 E2F1 WWC1 DLGAP5 E2F3 PTCRA PBX1 TACC3 TFDP1 FNTA TFDP2 JAK3 CDK4 CCNE1 CDK2 FLT3 ERCC6L NUP107 TYK2 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A S1PR1 KNTC1 KNL1 SGO1 DYNC1LI1 RCOR1 SGO2 FNTB;CHURC1-FNTB CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 SNX3 NUP160 SKA1 SKA2 DSN1 NUP85 RAD21 RCC2 NDC80 ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 STRAP CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 HSPB1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE BAD CENPF CASP9 CENPH CENPI TAOK1 CENPK CENPL CPNE8 CENPM DOCK8 FNBP1L B9D2 FNBP1 CENPO CENPP SCRIB CENPQ NIPSNAP2 RAB4B SPC24 RHOJ SPC25 CDC42BPB MAD2L1 CDC42BPA SLC4A7 NUP37 FMNL3 SPINT1 HPN MST1 SPINT2 MST1R OXTR AVPR1B AVPR2 AVP AVPR1A OXT-1 DSP TJP1 CASP3 DSG1 DSG2 TJP2 POLR2A POLR2B ZRANB1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CDC73 POLR2I POLR2L LEO1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 H2AC14 AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A2 PRKAB1 CSNK2B TRIB3 EPAS1 MAPKAP1 AXL PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 PIK3R5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN WWTR1 JUND YES1 MOV10 AGO4 H2AC20 AGO2 CD28 H2AB2;H2AB3;H2AB1 EZH2 PRKAG1 PRKAG2 ASH2L PRKAG3 RAC1 JAK1 FOS VAV1 H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 DERL2 PAK1 OS9 SPOP RICTOR PAK3 PAK2 SUZ12 H2BC5 STAT1 STAT3 MIB2 H2BC1 FOSB VCP-1 CD86 CD80 GRAP2 H2AC4 MYCN CD274 TCF7 SEL1L THEM4 PRR5 GSK3B DPY30 PTN PIK3CD PIK3CB ALKAL2 PIK3CG ALKAL1 H2BC21 WDR5 MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 PIK3CA HHIP BOC LCK GAS1 PRKAA1 CDON PRKAA2 LEF1 GLI1 KIF7 GPR161 CDC42 INTU TULP3 ERLEC1 FUZ RBBP4 ADCY10 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN PLD2 CSK RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 TNRC6B CCNK CCNT1 NELFB MEMO1 NRG2 NRG3 NRG4 TBP NCBP1 GTF2A1 GTF2A2 PXN TERT CDK9 NCBP2-1 CCNT2-1 DDX4 GJA1 GFAP CFTR RGS9 AXIN2 RGS6 RGS7 CFLAR CCR5 CCT2 SPHK1 PLAT TP53 MAGED1 EVC2 EFCAB7 ARL2 GNA14 EVC GAS8 GNA15 GNA11 CCT7 S100A9 S100A8 CCT6A ACTB-1 GNAQ RGS11 AAAS CX3CR1 IGF1R KPNA2 RPS6 ITGB5 TGFB1 MYL12B MYLK MYH11 ANXA1 TPM4 TPM3 CLTC CLTA MYL6 HSP90AA1 PARP1 PTPN12 LFNG MUC13 CBFB HHAT RUNX1 DISP2 SCUBE2 PTPRK LRIG1 FAM83D PAG1 FAM83A SPRY1 THBS2 FASN GALNT3 MUC20 SRRM1 DDX39B NPFFR2 NPFFR1 RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 NTSR2 GPR17 SOX2 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 GAST FFAR2 FFAR1 GPR39 EDN2 TRPC7 TACR2 TACR3 TACR1 TRPC6 F2 TRPC3 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT F2RL1 LAMA5 F2RL2 LAMB3 F2RL3 LAMA2 GPR68 LAMB2 GPR65 LAMA1 PMCH LAMC3 RGS4 LAMA4 RGS5 LAMA3 FN1 RGS2 RGS3 LAMB1 RGS1 LAMC2 LAMC1 GHSR CASR F2R LTB4R2 NTS MCHR2 KNG1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR MMP3 RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK HCRTR2 HCRTR1 KISS1 FFAR3;GPR42 TRAF6 PRKCQ ZAP70 RASGRP2 RASGRP4 UBE2D3;UBE2D2 TAB3 TAB2 TAB1 MC4R EDNRB RPS6KA1 AMER1 SOX9 YWHAH EDN1 EDN3 YWHAZ MC3R KIT HDAC1 MARK3 POMC MC1R ICMT ID1 MC5R SNAI2 CAV1 CGA C5AR2 TSHB VAV3 C5AR1 VAV2 CD19 PTPRO ITSN2 HSP90AB1 ROCK1 ROCK2 GPS1 GRK3 TWF1 MSI2 RHOBTB1 RHOBTB2 ACTG1 PIP5K1C TRA2B STK38 MYO6 RBBP6 SPEN RNF20 CPSF7 ACTN1 TMOD3 TXNL1 COPS4 CDC37 PICALM COPS2 PDE5A PHIP HNRNPC EPS15L1 VIM RBMX ULK3 DZIP1 EPN1 DBN1 SPOPL CTTN ARF6 FURIN PCSK6 PCSK5 TGFBR1-1 TRIP10 TGFBR2 CAB39L RPTOR STK11 EEF2K STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD AKT1S1 CAB39 EIF4EBP1 PGK1 SLC38A9 EIF4E EIF4B RHEB KDM4C-1 LAMTOR2 KLK3;KLK2 LAMTOR1 LAMTOR4 LAMTOR3 IDE LAMTOR5 EIF4G1 TIAL1 APC TIA1 RBFOX2 ESRP2 DHRS4 GPAM SP1 SCD DLG1 DLG3 DLG4 TRADD CASP8 FLOT1 TNFSF10 FLOT2 GZMH;GZMB-1 TRAF2 BCAP31 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PTPRJ BIRC2 BIRC3 XIAP RIPK1 FADD ELANE ITCH MMP9 FAS BAX STUB1 SAMM50 HNRNPM HNRNPF HNRNPA1-1 MTX1 AHCYL1 ATP2A3 ATP2A2 ATP2A1 PRKACA-1 DUSP16 PTBP1 SFPQ-1 CAMK2B CAMK2D CAMK2A ITPR1 ITPR2 ITPR3 CAMK2G HNRNPH1 RPS6KA3 RPS6KA2 MAPKAPK5 MDM2-2 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 RAP1GDS1 MFN1 MFN2 IL6 MYO19 TRAK2 CXCL8 BMI1 DOCK7 TNS4 TNS3 RING1 AATF MRTFA PRDM4 RNF2 MAPK8 MAPK7 CDKN2B SENP1 NTRK2 DOCK3 BDNF GAB1 GRIN2B FRS3 PTPN18 NTF4 TIAM1 NTF3 PLCG1 PTPN13 EGF BCL2 AREG BCL2L1 PTPN7 PTPN2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 MECOM CCL13;CCL2 STAP2 C5 C3-1 PORCN KHDRBS1 KHDRBS2 KHDRBS3 MYOG MYOD1 MYF6 TCF4 MYF5 SLC1A5 RACK1 FARP2 CDH5 TLE1 ST3GAL4 ST3GAL3 PARD6B GOLGA7-1 ZDHHC9 ACTN2 STK4 SAV1 STK3 LATS1 GRIN1 MOB1A;MOB1B GRIN2D LATS2 AMOTL2 AMOTL1 DLG2 LTK CAMK4 NEFL TNK2 EGR1 MYH9 RBPJ TGIF1-1 GATA3 CCNC-1 SFN COL1A2 HEY1 CASP10 HEY2 GGA3 RAB4A PPARD EGFR ULK1 SPP1 MBD3 USP9X GATAD2B GATAD2A SKI UACA IRS4 IGF2 IGF1 YY1 SYVN1 KDM3A KDM1B APOD ARL4C EEPD1 MRGPRD CMKLR1 KMT2B PDYN AGTR2 FOXO4 FPR1 SOCS3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 GPR37 GPR35 WLS CXCL2;CXCL3;CXCL1-1 PDGFD RGR CILP PLPPR1 CSN2-1 CCL11 MXD4 PLPPR2 VPS29 PLPPR3 VPS35 PLPPR4 TMED5 PLPPR5 CCL4L2;CCL4L1;CCL4 THBS4 THBS3 CCL19 PIN1 STMN1 GPHA2 VPS26A CCL17 CCL16 ADAP1 CCL25 BEX3 P2RY12 P2RY13 CCL22 PTEN CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B CCL3L1;CCL3L3;CCL3;CCL18 PSAP CXCL10 CXCL11 ECE1 PRLHR ADORA2A ITGA5 SRF P2RY4 CCL5 CCL1 APLN E2F5 ECE2;EEF1AKMT4-ECE2 RRH TAS2R3-1 CXCL5;CXCL6 PTGDR TAS2R16 GPR37L1 PTPN1 KEL TAS2R40 TAS2R41 TAS2R42 SST LHB NLN IL2RA MC2R PENK PPY CCR10 CCR1 TRIM33 PPBP TAS2R39 HCAR2;HCAR3 ACKR3-2 PTGDR2 NPY4R2;NPY4R CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 OXGR1 FSHB GPBAR1 TGFA GAL FSHR OPRD1 PTGER4 NPB PTGER2 APOE PTGER3 PCK1 CXCR5 CXCR6 CXCR1 NPW SMARCA4 CXCR3 SNW1 CXCR2 PRLH TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 MAS1 XK NPY2R CCRL2 NPY1R PRH1-TAS2R14;TAS2R14-3 APLNR SUCNR1 HCAR1 OPN3 FOXO1-1 OPN5 PYY TAS2R7 CXCL9 TAS2R8 GRM3 RXRB HEBP1 GRM2 GRM4 RXRG GRM7 GRM6 VEGFA GPER1 GRM8 TAS2R1 TAS2R4 PTGIR MAMLD1 NPY5R SSTR1 PRDM1 SSTR2 SSTR4 SSTR5 OPRL1 CNR2 CNR1 TAS1R2 S1PR3 TAS1R1 S1PR2 S1PR5 S1PR4 TAS1R3 TSHR ACKR4 IRAK1 ACKR2 ACKR1 SMAD2;SMAD3 IL2 IL3 BMP2 CAPZB CHD4 CHD3 YWHAQ TGIF2 TIMP2 TIMP1 MTA2 HELLS TGFB2 REST INHBA KRAS KLF16 ACVR2A MAML2 TGFBR3 MMP14 MAML1 MMP16 SERPINE1 GIPC1 SGK1-1 INHA MYB PIP4K2A PIP4K2B JUNB RNF111 PPP1R15A USP15 LTBP4 LTBP2 LTBP3 MTMR4 LTBP1 ITGB8 PMEPA1 ITGB6 E2F4-1 TGFB3 NEDD4L UCHL5 BAMBI ITGA8 USP8 RET RARG GLI3 GLI2 UBE2D3-1 RSPO3 DNAJB1 BAG4 TCF12 NCOR2 KAT2B KAT2A RARB GPS2 WWOX WWP1 CSF2 ITGA2B MEN1 USP7 PF4;PF4V1-1 USP2 FKBP5 NOTCH2 NOTCH3 NOTCH4 ABL1 SKIL CDK8 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 PELI3 PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 MAP3K1 TNIP2 USP18;USP41 CD14 MAP3K8 BTK NFKB2 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 PPP2R1B MAPK14 PPP2R1A TLR6 TLR2 MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 SOCS1 ATF2 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C FGB FGA MAPK9 MAPK8 FGG TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 SIGIRR CUL1 S100A1 CD36 RELA IRAK3 TIRAP RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB S100A9 S100A8 CASP8 RPS6KA5 TRAF2 PELI1 HMGB1-1 RIPK2 MYD88 ATF1 ECSIT SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2N IRAK4 VRK3 TAB3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures COL4A3 COL9A1 COL8A2 COL8A1 COL6A3 COL4A5 COL9A3 COL6A6 COL6A5 COL9A2 MMP7 BMP1 TLL2 TLL1 CTSS PCOLCE CTSB PLEC LAMB3 LAMA3 LAMC2 LOX LOXL3 LOXL4 LOXL1 LOXL2 COL1A1 COL1A2 MMP20 ITGB4 COL18A1 CTSV;CTSL COL15A1 ITGA6 MMP3 COL11A1 COL11A2 COL10A1 COL27A1 COL24A1 COL3A1 MMP9 COL2A1 COL5A1 COL4A2 CD151 COL4A1 COL7A1 COL6A2 COL5A3 COL4A4 MMP13 COL6A1 PXDN COL5A2 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMURF2 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 AXIN2 PSMD14 PSMD13 TNKS PSMA7 TNKS2 AXIN1 PSMB6 RNF146 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ10 KCNJ16 KCNJ1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases TNFAIP3 TNIP3-2 ESR1 NOD1 NOD2 IKBKG RHOA TNIP2 DDX58 IFIH1 RNF135 TRAF3 MAVS TRIM25 UBA52 PTEN UBE2D1 OTUD7A APC VCP-1 CDK1 OTUD5 OTUD3 VCPIP1 RIPK1 RPS27A RIPK2 UBB;UBC TP53 OTUB1 OTUB2 YOD1 TRAF6 TNIP1 RNF128 ZRANB1 OTUD7B PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation PPBP APOOL FLNA CFD ACTN2 TGFB1 A2M BRPF3-1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 ABCC4 SYTL4 VEGFA CD109 ALB TAGLN2 CLU NHLRC2 TEX264 STXBP2 LY6G6F;LY6G6F-LY6G6D SERPINA1 PDGFB ENDOD1 A1BG APOH PFN1 VTI1B SERPING1 RAB27B MANF CALU MAGED2 HRG F5 FERMT3 SERPINA3 F8 ECM1 OLA1 CTSW ORM2;ORM1 TIMP3 QSOX1 AHSG ANXA5 TOR4A CD63 CAP1 SPP2 VEGFB VEGFC ACTN1 VEGFD LHFPL2 PCYOX1L F13A1 CFL1 FAM3C LEFTY2;LEFTY1 APLP2 TMX3 TTN-1 SELENOP SCG3 TIMP1 TGFB2 RARRES2 CYRIB THBS1 SELP SCCPDH LGALS3BP WDR1 SERPINE1 PLEK PHACTR2 SRGN MMRN1 PECAM1 ITIH4 ITGB3 ITIH3 PLG CLEC3B CDC37L1 APOA1 FGB FGA TGFB3 VWF FGG PPIA TLN1 ALDOA VCL CALM3;CALM1 APP CD9 LAMP2 EGF IGF2 IGF1 CD36 TUBA4A PCDH7 HGF TF ITGA2B FN1 PROS1 PF4;PF4V1-1 KNG1 SOD1 HSPA5 CYB5R1 GAS6 PSAP OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency OTC OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling GNB1 GNB4 GNB3 GNB5 PPP3CA PPP3CB PPP3R1 CALM3;CALM1 KPNA2 PDE1C PDE1B PDE1A GRK2 PRKCD PLA2G4A PRKCG CDK5 POMC AHCYL1 PPP1CA GNAT3 PRKACA-1 ADCY9 GNAL PRKAR1B PRKACB-1 NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A GNA14 ITPR1 GNA15 GNGT1 ITPR2 GNA11 PDYN ITPR3 CAMKK1 CAMKK2 MAPK1 CAMK2G PRKCA PLCB3 PPP2R1B PLCB1 PPP2R1A PLCB2 ADCY4 GNAI3 PRKAR2A GNAQ ADCY3 PRKX PPP1R1B ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 PRKAR1A ADCY6 GNAI2 PDE4D-1 ADCY5 PDE4A PDE4C GNG10 GNG2 GNG5 GNG4 GNG8 OPRM1 PPP3CC PPP2CB;PPP2CA PPP2R5D PLCB4 GNG13 GNB2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification GNB1 GNB4 GNB3 GNB5 MAPK14 GNAI3 GNAQ GNA13 TBXA2R GNAI1 GNAI2 PLA2G4A P2RY12 GNG10 GNG2 GNG5 GNG4 GNG8 GNAT3 P2RY1 GNA14 GNA15 GNGT1 GNA11 AAMP GNG13 GNB2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation HERC6 TRAIP-1 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 CD14 RNF220 ANAPC7 RNF34 DET1 UBE2C LRSAM1 SH3RF1 UBE2E1 TRIM9 UBE2D1 ANAPC10 ARIH2 ANAPC11 LRRC41 MIB2 RNF144B CDC23 CTSS GAN RNF130 UBE2S CDC26 GPR75-ASB3;ASB3-1 CDC16 HUWE1 CDC27 KLHL2 KLHL3 UBE2G1 ANAPC4 UBE2G2 ANAPC5 KLHL9 ANAPC1 SPSB2 ANAPC2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 FBXO15 UBE2E2 UBE4A LMO7 FBXO10 FBXO11 KLHL41 KCTD6 KCTD7 RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 UBA5 SEC22B UBR4 KLHL11 SMURF2 KLHL13 SMURF1 UBR1 FBXO44 FBXO41 FBXO40 RBBP6 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 SEC31A ZBTB16 GLMN KLHL21 KLHL22 CTSV;CTSL BTBD6 FBXO30 LY96 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 ELOC-1 UBA3 RNF182 ELOB UBE2O TPP2 UBA1 BLMH UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 RNF138-1 FGB THOP1 FGA RNF213-2 BECN1 MGRN1 ASB13 TLR4 FGG ASB14 RNF6 ASB11 RNF7 ASB12 ASB17 RNF4 RCHY1 ASB18 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 ASB10 HECTD3 VHL FBXO4 TRIM41 RNF25 FBXO6 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXW4 FBXL16 FBXL13 FBXL14 FBXW10;CDRT1 FBXL12 FBXW5 TRIM39 ASB8 ASB9 FBXW7 ASB6 LNX1 FBXW9 TRIM36 FBXW2 ASB7 SEC23A ASB4 TRIM37 SAR1B ASB5 ASB2 TRIM32 ASB1 RBX1 SEC24B SEC24A SEC24D-1 SOCS3 SEC24C S100A9 S100A8 NCF1 NCF2 FBXO32 FBXL3 SNAP23 NCF4 FBXL5 CYBB CYBA TRIM63 PRKN HMGB1-1 ITCH STUB1 CALR-1 VAMP3 ATG14 CUL3 KBTBD7 MYLIP UBE2B ITGB5 BTK FZR1 SKP2 ITGAV CDC20 TLR1 CUL2 CANX TLR6 TLR2 SEC61A2 MRC2 PDIA3 SEC61A1 SEC61G SEC61B TAP2 TAP1 FCGR1A TAPBP STX4 CD207 SEC13 RNF111 NEDD4L PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC SKP1 CHUK FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 UBE2D3-1 S100A1 CD36 PSMA7 TIRAP PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 VAMP8 PSMC3 PSMC4 PSMC1 WWP1 PIK3R4 B2M MRC1 PIK3C3 HSPA5 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSME1 PSME2 ERAP2 MYD88 PSMB10 ERAP1 LRR1 CCNF PSMB8 KEAP1 PSMB9 CBLB UBE2L6 DCAF1 HERC5 HERC4 CDC34 HERC3 RNF115 RNF114 UBE2V1 HERC2 HERC1 FBXO7 UBE2D3;UBE2D2 TRIM21 UBE2N FBXO9 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen FGB FGA FGG ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors GRIA1 GRIA3 GRIA2 GRIA4 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation PIK3CD CTLA4 PIK3CB RAC1 PIK3CG MLST8 PDPK1 PPP2R1B PPP2R1A VAV1 PIK3CA LCK PAK1 CDC42 AKT2 RICTOR AKT3 PAK3 AKT1 PAK2 FYN TRIB3 MAPKAP1 MTOR CD86 PIK3R3 CD80 PIK3R2 PIK3R1 GRAP2 PIK3R6 MAP3K8 PIK3R5 LYN PPP2CB;PPP2CA PPP2R5E YES1 THEM4 PPP2R5B CD28 PPP2R5A PPP2R5D PPP2R5C MAP3K14 PRR5 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation EIF3F EIF3D EIF3A EIF3B RPS15 RPS14 RPS17 RPS16 RPS19 EIF4E RPS18 EIF4B RPS11 EIF4G1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS27A RPS25 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 PABPC1;PABPC3 RPS2 FAU EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPS27 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes NCAPD2 CDK1 SMC4 SMC2 CSNK2A2 NCAPG NCAPH CSNK2B CCNB2 CSNK2A1;CSNK2A3 CCNB1 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking NOSIP NOS3 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNB1 GNB4 GNB3 GNB5 KCNJ2 KCNJ3 KCNJ12;KCNJ18 ADCY4 KCNJ4 GNAI3 ADCY3 KCNJ5 ADCY2 GABBR2 ADCY1 GABBR1 ADCY8 KCNJ6 ADCY7 KCNJ10 GNAI1 ADCY6 GNAI2 KCNJ9 ADCY5 KCNJ15 KCNJ16 GNG10 GNG2 GNG5 GNG4 GNG8 GNAT3 GNAL ADCY9 GNGT1 GNG13 GNB2 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes SIRT1 MED7 MED20 NCOR1 TBL1XR1 H2AJ PAXIP1 PLIN2 H2BC5 LIPE H2BC1 DGAT2 CDK5 CD36 ANGPTL4 H2AC4 LPL FABP4 RB1 PHLDA1 NCOR2 ACSL1 KMT2C PEX11A PLIN1 LPIN1 MGLL CIDEC GPS2 KMT2D ELOVL5 DPY30 PLIN4 GPAM MED31-1 SCD MED30 H2BC21 THRSP WDR5 NCOA3 PNPLA2 NR5A2 H2AZ2;H2AZ1 RXRA KDM6A H2AC14 CCNC-1 AGPAT2 PAGR1 RBBP5 PPARGC1B ACSS3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AJUBA HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MED16 MED17 CEBPA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MED12 MED14 MED13 ABL1 MED10 EP300 H2AC20 H2AB2;H2AB3;H2AB1 ADIPOQ PPARGC1A NCOA1 MED27 MED1 PDK4 NCOA2 CDK8 ASH2L MED23 CREBBP NCOA6 MED4 MED6 MED24 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 RAC1 PELP1 EGFR RASA1 ELMO1 DOK1 EGF UBA52 EREG STAT3 BTC HBEGF RPS27A CDKN1B SFPQ-1 UBB;UBC CBL CCND1 NRG1 CDK4 CCNE1 NRAS CDK2 SOCS3 HRAS STAP2 NR3C1 KHDRBS1 KHDRBS2 KHDRBS3 RHOA CRK AKT1 EPAS1 PTK6 HIF1A ARHGAP35 SRMS ARAP1 ERBB2 NRG2 NRG3 NRG4 ELMO2 PTPN1 DOCK1 PXN BCAR1 GPNMB LRRK2 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase CLSPN BMX SATB1 PRKCD PAK2 LMNB1 APC KPNB1 CASP7 CDH1 DSP DBNL TJP1 CASP3 GAS2 CTNNB1 MAPT OCLN-1 DSG1 ADD1 PKP1 PLEC DSG2 DSG3 TJP2 FNTA PTK2 ROCK1 CASP8 SPTAN1 DFFB DFFA HMGB2 KPNA1 CASP6 BCAP31 BIRC2 VIM HMGB1-1 H1-0 H1-3 H1-2 H1-5 H1-4 GSN STK24 STK26 DNM1L PRKCQ ACIN1 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation FN1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 ITGB1 ITGA5 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PSMD8 PSMD6 PLK3 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GSK3B MAPK14 CSNK1A1 TPTEP2-CSNK1E;CSNK1E NEK11 MAPK11 CHEK1 CHEK2 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System TAX1BP1 PRKCD NLRC4 UBE2D1 UNC93B1 TLR8 TLR7 CTSS TLR3 LGMN CTSB HSP90B1 CRP FCER1G CFD C1QB COLEC11 COLEC10 C1S C1R FCN2;FCN1 MBL2-1 MASP1 C1QC TNFRSF1B CTNNB1 CGAS DDX41 LRRFIP1 AIM2 IRF7 TRIM56 PRKDC DHX9 IFI16 DHX36 STAT6 XRCC6 NRAS XRCC5 RAP1A TREX1 MAP2K2;MAP2K1 STING1 MAPK1 SERPINA1 HRAS MAPK3 A1BG CTSC MAPK14 HRG MAPK12 MAPK13 MAPK11 SERPINA3 MAPKAPK3 MAPKAPK2 ORM2;ORM1 QSOX1 SOS1 AHSG CRK ARG1 CD63 ATF2 CD59 CFL1 CASP2 TRAPPC1 CTSV;CTSL LY96 HBD;HBB CD177 EP300 HMOX1 APOB PECAM1 MEF2C CREBBP AAMP IQGAP1 CLEC4A RAP1B CLEC4D CLEC4E CLEC7A CLEC6A FGB CARD9 FGA TLR4 FGG PPP3CA PRKCE PPP3CB RAF1 PPIA RASGRP1 VCL PPP3R1 NFATC3 LTA4H NFATC2 NFATC1 CALM3;CALM1 APP JUN STK10 TCIRG1 CAPN1 FTH1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 SLC44A2 STOM DBNL ATP6V1B2 ATP6V0D1 JUP ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A CAND1 DIAPH1 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D ADGRE5 HMOX2 ATP6V1C1 ADGRE3 ATP6V1C2 ATP6V0A1 ATP6V1F FTL-1 ATP6V0E2;ATP6V0E1 LCN2 ZBP1 TBK1 IRF3 NLRP4 DTX4 ACAA1-1 SLC27A2 DSC1 BIN2 CD55 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB1 DEFB123 DEFB121 DEFB109B DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 DEFB114 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB110 DEFB130B;DEFB130A DEFB105A;DEFB105B DEFB103A;DEFB103B AP2A2 VAPA DEFB4A;DEFB4B HEXB LIMK1 NPC2 ATG12-1 GLB1 ATG5 GUSB ARSB PRKACB-1 FUCA1 A2M IDH1 TNFAIP3 CYLD PPP2R1B PPP2R1A DYNC1LI1 BST1 DSN1 GNS PLD3 OTUD5 PLPP5 PLPP4 DERA PPP2CB;PPP2CA PYGB MIF CNN2 PYGL GSN PPP2R5D MANBA PGAM1 GAA CYB5R3 ALDOC ALDOA CD44 DYNC1H1 RAB3D AGL-1 RAB44 CASP9 RAB37 RAB4B GYG1 RAB24 DSP CASP3 DSG1 PKP1 TKFC MLEC P2RX1 POLR2E POLR2F POLR2H POLR2L COPB1 MAN2B1 HPSE B4GALT1 H2AC14 PLAC8 EEA1 PLAUR TASL RBSN IRF5 HK3 PROS1 PGM2 CD33-1 CSNK2B PGM1 PIK3R2 PIK3R1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN CPNE3 YES1 RAB10 H2AC20 RAB14 H2AB2;H2AB3;H2AB1 RAB27A CD3G MAGT1 ATP8A1 RAC1 GALNS ATP11B PFKL ATP11A FOS VAV1 SNAP29 AOC1 OPTN-1 PAK1 TICAM2 TICAM1 TANK PAK3 ADA2 TRAF3 CD14 PAK2 IKBKE ATP8B4 H2BC5 HP;HPR H2BC1 VCP-1 ATP7A GRAP2 MAP3K8 ANO6 H2AC4 AMPD3 ITGAM ITGB2 SURF4 APRT NFKB2 PNP-1 ITGAX MAP3K14 CD47 PIK3CB H2BC21 PDPK1 H2AZ2;H2AZ1 DDOST APEH PIK3CA LCK LPCAT1 CDC42 AGPAT2 PLA2G2A-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN PLD2 PTPN11 CD4 H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 TCN1 ASAH1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 NAPRT PDXK LAMP2 CCT2 PLAU COMMD9 SERPINB6-2 TP53 COMMD3 TXK CCT8 S100A9 S100A8 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 RHOA DDX58 ICAM2 IFIH1 ICAM3 RNF135 RELB SIKE1 CLEC4M;CD209-2 MAVS TRIM25 RPS6KA5 RAB5B CYFIP1 RAB5C MMP25 STBD1 RHOG ADAM8 PANX1 ELMO2 DOCK2 DOCK1 HSPA1A;HSPA1B MMP8 RAB7A PLD1 IQGAP2 ARMC8 KCNAB2 SIRPA;SIRPB1;SIRPG SELL TEC TREM1 OLR1 LYZ-1 CST3 DGAT1 TTR KPNB1 FABP5 TSPAN14 ART1 ISG15 DEFA6;DEFA4;DEFA5 PRSS3;PRSS2;PRSS1 SIRPB1 ANPEP KLRC4-KLRK1;KLRK1 LAIR1;LAIR2-1 MME ITGAV SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 ATP6AP2 ANXA2 PTK2 OSCAR CD300E HSP90AA1 DNAJC3-1 CD180 LY86 LBP SIGLEC5;SIGLEC14 BPI KLRC4;KLRC3;KLRC2;KLRC1 NCK1 CAP1 MUC12 MUC13 MUC15 KLRD1 MUC3A MUC5AC MYO9B CFP VNN1 PDZD11 MUC1 MUC2 SLC15A4 MUC7 MUC4 MUC6 MUC17 MUC5B NDUFC2;NDUFC2-KCTD14 MUC20 MUC21 NEU1 MGST1 CTSA ELK1 FPR2 CTSZ TXNDC5 TRPM2 HSPA8 DNM2 VAMP8 F2 PTAFR PIK3R4 VTN SRP14 GAB2 KNG1 B2M TLR9 PIK3C3 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CKAP4 TOLLIP UBE2L6 HERC5 CDC34 SLCO4C1 ITK TRAF6 PRKCQ UBE2V1 LCP2 RASGRP2 RASGRP4 UBE2D3;UBE2D2 TRIM21 LAT2 UBE2N TAB3 TAB2 TAB1 RPS6KA1 ARSA ATG7 ARHGAP9 HUWE1 SLC11A1 CPB2 CD81 C5AR2 CFI VAV3 C5AR1 C4BPA C4BPB C8B C8A NME2 CLU CPN2 CPN1 C8G C6 VAV2 C7 IMPDH1 CD19 C9 IMPDH2 CR2 CFHR1;CFHR2 FAF2 SERPING1 FCER1A CFH-3 MS4A2 HSP90AB1 RHOF ROCK1 UBA7 UBR4 ACTG1 ARHGAP45 NLRP1 SOCS1 UBA3 MOSPD2 UBE2K GDI2 HGSNAT CAB39 LAMTOR2 LAMTOR1 RAB31 LAMTOR3 SNAP25 DHX58 RNF125 RNF216 FRMPD3 RAB18 GMFG ABCA13 ALDH3B2;ALDH3B1 PGLYRP1 NHLRC3 MCEMP1 NOS2 SCAMP1 UNC13D RNASE3;RNASE2-2 PADI2 TRIM32 SERPINB3;SERPINB4-1 CRACR2A PRDX4 S100A11 PA2G4 PIGR SERPINB1 NFAM1 CHRNB4 TMC6 PLEKHO2 SERPINB10 SERPINB12 GRN AGA ERP44 LRG1 YPEL5 GHDC TMEM179B EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A BRI3 PTPRB NIT2 NCKAP1 GM2A ACP3 WASF1-1 NCF1 RNASET2 NCF2 TMBIM1 SNAP23 CANT1 CASP8 NCF4 FGL2 CASP1 PRCP CPPED1 VPS35L C6orf120 KRT1 METTL7A-1 PCBP2 RIPK3 SLPI CRISPLD2 IL18 TMEM63A BST2 TRAF2 ALAD SYNGR1 IL1B CYBB VAT1 PTPRN2 CYBA STK11IP PELI1 PRG2 NBEAL2 PRG3 S100A7A;S100A7 PTPRJ GLIPR1 CAMP BIRC2 CD53 BIRC3 RAP2B ACTR10 DNASE1L1 NCKAP1L CSTB PAFAH1B2 C1orf35 WASF2 PGRMC1 PPIE SDCBP BAIAP2 HMGB1-1 ATAD3A;ATAD3B CREG1 RIPK1 ORMDL3 ABI2 GCA ABI1 FADD PTGES2 ELANE SVIP GSDMD QPCT CASP5;CASP4 CD68 ITCH MPO DYNLT1 C1QBP COTL1 ENPP4 MMP9 OSTF1 CD93 IRAG2 DOK3 GSDME PTPRC ADGRG3 DPP7 GGH TREM2 DNAJC13 TARM1 DEGS1 MS4A3 SLC2A5 TNFAIP6 CRISP3 HEBP2 PSEN1 CHI3L1 CLEC12A MVP NCSTN TMEM30A CMTM6 PDAP1 S100P PTX3 HCK GLA ELMO1 TYROBP DDX3X-1 CYFIP2 CLEC5A WIPF1 WIPF2 WIPF3 PYCARD AHCYL1 C3AR1 PRKACA-1 NOS1 BTK MEFV NCKIPSD FCGR3A;FCGR3B PLCG2 NLRP3 ITPR1 MYO5A ITPR2 ARPC4 ARPC5 ARPC2 ITPR3 ARPC3 ACTR3-1 ARPC1B ARPC1A WASL PSTPIP1 TOMM70 CTSG ACTR2 SYK TLR1 FGR TLR6 TLR2 WAS RPS6KA3 RPS6KA2 FCGR1A MAP2K3 MAP2K4 WASF3 MYO10 P2RX7 MYO1C LTF SUGT1 TXN MAP2K7 MAP2K6 FRK PLD4 MAPK9 MAPK8 MAPK7 HVCN1 IFNB1-4 MAPK10 PLCG1 BCL2 SIGIRR BCL2L1 EEF1A1 S100A1 CD36 EEF2 IRAK3 TIRAP ADAM10 ALOX5 C5 PRDX6 C3-1 LOC110384692;C4A;C4B_2;C4B CFB C2 MGAM PGLYRP4 PGLYRP3 PGLYRP2 CHIT1 GSTP1 LEAP2 ATOX1 EPPIN;EPPIN-WFDC6 LPO RNASE6 RNASE7 ITLN2;ITLN1-2 RIPK2 MYD88 BPIFA1 REG3G;REG3A-1 BPIFB1 BPIFB4 BPIFB6 ATF1 ECSIT SAA2;SAA1 NKIRAS1 NKIRAS2 IKBIP DUSP4 CHGA MEF2A DUSP3 IRAK4 VRK3 SIGLEC15 DUSP6 DUSP7 TLR10 TLR5 LRRC14 USP14 NLRX1 PELI3 PELI2 NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 PRKCSH MAP3K1 TNIP2 USP18;USP41 PKM GOLGA7-1 MYH9 TIFA ALPK1 ILF2 TXNIP IST1 CASP10 TBC1D10C CEP290 ACLY PLA2G6 CR1L;CR1 FUCA2 BPIFB2 CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D FPR1 POLR3E POLR1C POLR3F POLR1D POLR3G POLR3H POLR3K CXCL2;CXCL3;CXCL1-1 PIN1 ITGAL RAB6A APAF1 PSAP NOS3 IGF2R RAB9B ACTR1B CTSH PTPN4 PPBP LGALS3 CCR6 CCR2 CXCR1 CXCR2 CTSK CTSD GPR84 IRAK1 SPTAN1 DNM1 DNM3 CAT CAPZA1 CAPZA2 RETN TIMP2 NFASC PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 NF2 SKP1 CHUK FBXW11 CDK13 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 GPI PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 UBE2D3-1 RELA PSMA7 MALT1 CDA PSMB6 PSMB7 PSMB4 PSMB5 RAB3A PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 HSPA6 SEM1 NFKBIA PSMC5 F12 PSMC6 KLKB1 PSMC3 PSMC4 PSMC1 DNAJC5 NFKBIB MRE11 ABL1 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair POLD2 POLE RFC5 RFC3 RPA1 RFC4 RPA2 RFC1 FEN1 RFC2 POLE4 LIG1 RPA3 POLE2 POLE3 PCNA POLD3 POLD4 POLB APEX1 POLD1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 PPP1R12A HAUS2 HAUS1 CLASP1 BTRC DYNC1H1 SKP1 NDE1 CEP63 OPTN-1 YWHAE FBXW11 AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 UBA52 HAUS8 PPP1CB HAUS7 CCNB1 PCNT CUL1 OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 RPS27A CEP250 UBB;UBC CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CCNB2 CEP57 AJUBA CETN2 CEP164 ACTR1A AURKA MAPRE1-1 CNTRL CEP290 BORA RAB8A CKAP5 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors GP1BB GP5 F12 KLKB1 F9 KNG1 F11 GP1BA GP9 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation POLE PRIM2 POLE4 PRIM1 POLA1 POLA2 POLE2 POLE3 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GAA RPIA GALNS HGSNAT G6PC3 ALDOB G6PC1 SGSH TALDO1 SI IDUA PPP1R3C LCT NHLRC1 UBA52 SLC37A4 GNS HYAL1 DCXR GLB1 NAGLU IDS GYG2 GUSB GYG1 ARSB EPM2A RPS27A UBB;UBC GBE1 KHK GYS2 GYS1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions DAB2 GJA1 CLTCL1 DNM1 DNM2 AP2M1 CLTB CLTC CLTA SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions PGF KDR FLT4 FLT1 VEGFA VEGFB VEGFC VEGFD ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase HSPA1L HSP90AA1 PTGES3-1 DNAJB1 HSPA2 HSP90AB1 HSF1 HSPA8 EP300 CREBBP HSPA1A;HSPA1B FKBP4 HSBP1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase NEK9 NEK6 NEK7 NUP43 H2AJ RANBP2 PRKCB PLK1 H2BC5 LMNB1 GOLGA2 CCNB1 H2BC1 NUP37 CDK1 H2AC4 KMT5A RB1 SET-1 ARPP19 LPIN1 NCAPH2 LPIN2 NCAPG2 LPIN3 SMC4 SMC2 ENSA NCAPD3 RAB2A CTDNEP1 BLZF1 CNEP1R1 MASTL GORASP2 NUMA1 PPP2R2A;PPP2R2D MCPH1 MAPK1 NUP107 H2BC21 PRKCA PPP2R1B H2AZ2;H2AZ1 PPP2R1A GORASP1 H2AC14 NUP205 NUP188 RAB1A AAAS NUP42 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP62 RAB1B NUP160 TPR BANF1 USO1 NUP88 CCNB2 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 NUP153 H2BC15;H2BC3;H2BC11;H2BC12 NUP93 NUP50 POM121;POM121C NUP35 VRK1 NUP54 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LEMD2 PPP2CB;PPP2CA EMD SEC13 H2AC20 NUP133 LEMD3 H2AB2;H2AB3;H2AB1 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ERCC6L NUP107 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 SKA1 SKA2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA ESPL1 MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC PSMD8 NUP43 BUB3 PSMD6 BUB1 PSMD7 DYNC1I1 PSMD2 CLASP1 PSMD3 CLASP2 PSMD1 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF PTTG1;PTTG2 CENPH PSMC2-1 CENPI PSMA5 TAOK1 PSMA6 CENPK PSMA3 CENPL PSMA4 CENPM PSMA1 B9D2 UBA52 CENPO CENPP PSMD12 CENPQ PSMD11 SPC24 PSMD14 SPC25 PSMD13 MAD2L1 NUP37 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions ITGB4 CASK ITGA2 TRAPPC4 PRKCA ITGA6 ITGB5 TGFB1 THBS1 SDC1 FGF2 TNC VTN ITGB3 SDC4 ITGB1 SDC2 ITGAV ACTN1 SDC3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPL34 EIF3F RPL10A EIF3D RPL8 EIF3A RPL9 EIF3B RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 RPS27 EIF4E EIF4B EIF4G1 UBA52 RPS27A EIF2S2 EIF2S3;EIF2S3B EIF2S1 EIF4A2 EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M RPL4 EIF3K RPL30 EIF3L RPL3 EIF3I EIF3J RPL32 EIF3G EIF3H RPL31 EIF3E DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 CYP11B1;CYP11B2 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR3 GIPC1 TGFBR1-1 TGFBR2 ARRB1 TGFB2 TGFB1 ARRB2 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis GP1BB FGB GP5 FGA VWF FGG F10 ANO6 F11 F5 F8 GGCX TPST2 PROC TPST1 F9 ADAMTS13 PROS1 F2 GP1BA GP9 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHB DBT DLD BCKDHA SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) FLT3 PIK3CB HRAS PDPK1 FRS2 KLB IRS1 PDE3B PIK3CA PIK3R4 IRS2 CILP FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 GAB1 FGF9 SOS1 AKT2 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 IRS4 IGF1R FGF10 IGF2 PTPN11 FLT3LG IGF1 PIK3R2 PIK3R1 THEM4 NRAS REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins PROC F7 GAS6 FURIN F9 F10 PROS1 F2 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 HRAS FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 SOS1 FGF20 FGF23 FGF22 FGF16 FGF18 NRAS FGF10 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AMACR CYP46A1 CYP39A1 SLC27A5 CYP27A1 HSD3B7 AKR1D1 CYP8B1 SLC27A2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle SLC18A3 RAB3A SLC5A7 RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 CHAT UNC13B SNAP25 CPLX1 SYT1 TSPOAP1 STX1A VAMP2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins AQP2 AQP3 AQP11 MIP AQP9 AQP1 AQP8 LOC100509620;LOC112267859;AQP7 AQP6 AQP10 AQP4 AQP5 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex MTMR4 LTBP1 ITGB8 PPM1A NCOR1 STRAP PMEPA1 ITGB6 E2F4-1 CDK9 TGFB3 UCHL5 NEDD4L CCNT2-1 TRIM33 BAMBI ITGA8 CDKN2B USP9X FKBP1A SKI UBA52 UBE2D1 PPP1CB HDAC1 UBE2D3-1 SNW1 PPP1CA ITGB5 NCOR2 RPS27A TGFB1 UBB;UBC CBL TFDP1 TFDP2 ITGAV TGIF1-1 SP1 MAPK1 MAPK3 PARP1 PPP1CC ATP1B4 ARHGEF18 CGN F11R PRKCZ RHOA PARD6A SMAD2;SMAD3 PARD3 SMAD4 CCNC-1 SMURF2 MYC MEN1 SMURF1 SMAD7 ITGB1 COL1A2 YBX1 TGIF2 CCNK CCNT1 RBL1 WWTR1 TGFB2 XPO1 TGFBR3 SKIL SERPINE1 EP300 E2F5 FURIN ITGB3 TGFBR1-1 JUNB TGFBR2 STUB1 RNF111 CDK8 PPP1R15A USP15 LTBP4 LTBP2 LTBP3 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) FGB S100A1 FGA CD36 TIRAP S100A9 FGG TLR4 S100A8 LY96 TLR1 TLR6 HMGB1-1 TLR2 BTK MYD88 CD14 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 JAG2 JAG1 ADAM10 DLL1 DLL4 ADAM17 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism LYVE1 HYAL1 HYAL3 HYAL4 CHP1 GUSB SPAM1 CD44 STAB2 CEMIP HAS1 SLC17A5 HEXB HMMR HYAL2 HAS3 HEXA SLC9A1 HAS2 ABCC5 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1 UBIAD1 VKORC1L1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K NTRK2 BDNF GAB1 PIK3R1 NTF4 PIK3CA GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization MAPK1 CDK1 GORASP1 RAB1A RAB2A RAB1B PLK1 BLZF1 USO1 CCNB2 GOLGA2 CCNB1 GORASP2 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CCND2 CCND1 CDK6 CDK4 CCND3 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion GNG5 GNB1 GNG4 GNB4 CACNA1D GNB3 GNG8 GNB5 ADRA2C ADRA2A CACNA1C CACNB2 CACNB3 GNAI1 ADCY6 GNAI2 ADCY5 CACNA2D2 GNG13 GNGT1 GNG10 GNB2 GNG2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 CHRNA2-1 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis MAPK1 TRIM27 RAB5A RNF213-2 VPS33B MAPK3 ENO1 CTSG CORO1A KPNB1 PGK1 NOS2 DUSP16 RPS27A SFPQ-1 UBB;UBC HGS GSK3A UBA52 ATP6V1H KPNA1 RAB7A VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ASAH1 ATP6V1B2 ATP6V1C1 ATP6V0D1 ATP6V0C ATP6V1A ATP6V1E1 ATP6V0E2;ATP6V0E1 ATP6V1G1 ATP6V0B ATP6V1H SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse ARHGEF11 MYH10 ARHGEF12 RHOC MYL6 RHOB RND1 ROCK1 ERBB2 ROCK2 RHOA MYL12B PLXNB1 MYH11 MYH9 SEMA4D LIMK2 LIMK1 MYH14 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants PIK3R1 CUX1 FGFR1OP2 MYO18A CPSF6 PIK3CA CEP43 STAT5A STAT5B LRRFIP1 GAB2 TRIM24 STAT1 STAT3 ZMYM2 BCR IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs IFNGR2 JAK2 MAPK1 JAK1 MAPK3 IFNG RAF1 IFNGR1 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 LEF1 LFNG PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 DLL1 PSMB4 TBX6 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 NOTCH1 HES7 PSMA2-1 MESP2 EPHA4 SEM1 CTNNB1 MSGN1 PSMC5 RIPPLY2 PSMC6 DLL3 PSMC3 PSMC4 PSMC1 RBPJ TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK RFC5 RFC3 RPA1 RFC4 RPA2 REV3L RFC1 RFC2 REV1 MAD2L2 RPA3 RPS27A UBB;UBC PCNA UBA52 POLK RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events RBP1 OPN1SW TTR RLBP1 LRAT NAPEPLD OPN1MW3;OPN1MW2;OPN1MW;OPN1LW STRA6 RDH12 RBP4 ABCA4 RDH5 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets DUSP6 DUSP7 MAPK1 MAPK3 MAPK7 RPS6KA1 MAPK14 PPP2R1B PPP2R1A PPP2CB;PPP2CA MAPK11 PPP2R5D RPS6KA3 RPS6KA2 RPS6KA5 DUSP4 MEF2C ELK1 MEF2A DUSP3 VRK3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation RAC1 VAV1 ELMO1 NF2 PAK1 LIMK1 CYFIP2 WIPF1 WIPF2 WIPF3 BTK NCKIPSD FCGR3A;FCGR3B VAV3 MYH9 MYO5A ARPC4 ARPC5 PTK2 ARPC2 ARPC3 MAPK1 ACTR3-1 ARPC1B VAV2 ARPC1A WASL MAPK3 HSP90AA1 ACTR2 SYK ACTB-1 NCKAP1 WASF1-1 WAS HSP90AB1 CDC42 CRK ACTG1 NCK1 FCGR1A WASF3 MYO10 CYFIP1 MYO1C CFL1 NCKAP1L WASF2 MYO9B ABL1 BAIAP2 ABI2 ABI1 ELMO2 CD3G DOCK1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors MCCC2 MCCC1 SHMT2 PC LDLRAP1 CUBN AMN PRSS3;PRSS2;PRSS1 PCCA MMAA PCCB MMUT PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 PARP10 MMAB MMACHC MMADHC NT5E BST1 ST20-MTHFS;MTHFS SLC46A1 ALDH1L1 CTRB1;CTRB2 NADSYN1 PANK4 ALDH1L2 PANK3 FLAD1 PANK1 NUDT12 SLC25A51;SLC25A52 DCAKD SLC52A1;SLC52A2 COASY SLC5A8 PPCDC BTD SLC25A16 SLC5A6 MTHFD1 MTHFD2 VNN1 MTHFD2L NUDT8 VNN2 LRP2 SHMT1 PPCS HLCS PDZD11 PNPO FASN ENPP2 SLC19A3 ENPP1 NADK ENPP3 SLC19A1 SLC25A42 SLC19A2 NAMPT CBLIF AASDHPPT SLC52A3 MTHFR TCN1 CD320 MOCS2 MOCS3 QPRT GPHN THTPA NADK2 SLC22A13 CYB5A SLC23A2 NMRK2 CYB5R3 RFK SLC23A1 NMRK1 NAPRT CD38 ACP5 AOX1 SLC25A19 PDXK NAXE MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 NMNAT1 SLC25A32 NAXD ACACB ACACA DHFR2;DHFR FOLR2 MTRR NNMT GSTO1 MTR-1 GSTO2 TCN2 SLC2A1 ABCC1 ABCD4 LMBRD1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA NUP107 NCBP2-1 NUP43 SLBP EIF4E RANBP2 NUP205 NUP188 NXF1 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 ALYREF NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 NCBP1 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT2 CNOT3 CNOT8 CNOT9 PLAGL1 TNKS1BP1 PLK3 NPM1-2 RGCC TP53 CNOT6L PLK2 CENPJ CNOT10 CDC25C CNOT4 BTG2 CNOT6 CNOT7 CNOT11 CNOT1 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) SV2C SV2B SV2A VAMP1 VAMP2 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer CEBPB BCL2A1 RNF213-2 MAPK9 MAPK8 VCL RANBP2 AGO3;AGO1 SKP1 FRS3 CARS1 JUN PLCG1 UBA52 STAT1 STAT3 HDAC1 CCNB1 EEF1G CUL1 RPS6 SQSTM1 ATIC RB1 CDKN1A RPS27A UBB;UBC IL10RA RBX1 TP53 STAT5A PPFIBP1 IL10 KIF5B GRB2 MYH9 TPM4 CLTC TPM3 PIK3CB MAPK1 TYK2 TFG MAPK3 PRF1 LMO7 FOXM1 FRS2 ICOS IRS1 ZC3HC1 PIK3CA DCTN1 WDCP ALK NPM1-2 GCC2 EML4 FN1 PPM1B HIP1 BCL11A PRKAR1A GZMH;GZMB-1 EIF2AK3 STRN BIRC6 TPR MDM2-2 SEC31A TNRC6C PIK3R2 PIK3R1 PTPN6 MOV10 AGO4 KLC1 AGO2 MCL1 JUNB DNMT1 RRBP1 ZAP70 IRF4 MSN IL22 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 HGF MET STAT3 NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects APRT HPRT1 ADA ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System HERC6 TAB2 TRAIP-1 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 YWHAZ RNF220 ANAPC7 RNF34 DET1 UBE2C LRSAM1 UBE2E1 SH3RF1 TRIM9 UBE2D1 ANAPC10 ARIH2 ANAPC11 LRRC41 RNF144B CDC23 CTSS GAN RNF130 UBE2S LGMN CDC26 GPR75-ASB3;ASB3-1 CDC16 CTSB HUWE1 CDC27 KLHL2 KLHL3 ANAPC4 UBE2G1 ANAPC5 UBE2G2 ANAPC1 KLHL9 SPSB2 ANAPC2 SPSB1 SH3KBP1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 CDH1 UBE2D4 CTNNB1 UBE3C UBE3D FBXO27 UBR2-2 LTN1 CD81 RNF19B SH3GL2 UBE3A UBE3B UBE2Z FBXO21 FBXO22 YWHAB NPEPPS NRAS RNF19A RAP1A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 HRAS FBXO15 CD19 UBE2E2 UBE4A CTSC LMO7 FBXO10 FBXO11 KLHL41 XDH KCTD6 KCTD7 RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 SEC22B UBA5 UBR4 SOS1 KLHL11 SMURF2 KLHL13 SMURF1 RAPGEF3 UBR1 RAPGEF4 FBXO44 FBXO41 FBXO40 RBBP6 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 SEC31A GLMN KLHL21 KLHL22 CTSV;CTSL BTBD6 FBXO30 LY96 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 UBE2O TPP2 UBA1 EP300 BLMH UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL CREBBP DTX3L PJA2 PJA1 RAP1B TRAF7 UBE2R2 RNF138-1 FGB THOP1 RNF213-2 BECN1 FGA MGRN1 ASB13 TLR4 FGG ASB14 RNF6 NFE2L2 ASB11 PPP3CA RNF7 PPP3CB ASB12 RAF1 PPIA ASB17 RASGRP1 RNF4 RCHY1 RASGRP3 PPP3R1 ASB18 NFATC3 FBXL22 NFATC2 ASB15 NFATC1 ASB16 FBXL20 CALM3;CALM1 ZNRF1 FKBP1A ZNRF2 HECTD1 HECTD2 JUN ASB10 HECTD3 VHL TRIM41 RNF25 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 ASB6 LNX1 TRIM36 ASB7 SEC23A ASB4 TRIM37 SAR1B ASB5 ASB2 TRIM32 ASB1 RBX1 SEC24B SEC24A SEC24D-1 SEC24C PPL DCTN1 NCF1 NCF2 SNAP23 NCF4 CYBB CYBA DCTN6 PTPRJ DCTN5 DCTN4 RACGAP1 CAPZA3 PRKN ACTR10 HMGB1-1 ITCH RAP1GAP STUB1 PTPRC TREM2 ATG14 CD8B;CD8B2 CUL3 AP2A1 AP2A2 KBTBD7 TYROBP AP2M1 MYLIP UBE2B AHCYL1 PRKACA-1 PRKACB-1 AP2S1 BTK FZR1 CCND1 STIM1 FCGR3A;FCGR3B ORAI2 ORAI1 SKP2 PLCG2 AP2B1 ITPR1 BLNK ITPR2 CDK4 ITPR3 CDC20 CD79B CD79A SYK TLR1 PPP2R1B PPP2R1A TLR6 TLR2 WAS DYNC1LI1 DYNC1LI2 PDIA3 FCGR1A KIF18A PPP2CB;PPP2CA PPP2R5E SEC13 INPP5D PPP2R5B PPP2R5A PPP2R5D PPP2R5C KIF2A KIF2C KIF2B DYNC1I2 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L DYNC1I1 COLEC12 DYNC1H1 CENPE PTPN22 PLCG1 S100A1 CD36 TIRAP C3-1 H2AC14 AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A2 PRKAB1 CD33-1 MRC1 CSNK2B TRIB3 ATF3 HSPA5 RPN2 EPAS1 MAPKAP1 DAPP1 RPN1 PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 PIK3R5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN WWTR1 JUND RIPK2 ERAP2 YES1 ERLIN1 MYD88 ERAP1 ERLIN2 MOV10 AGO4 H2AC20 AGO2 CD28 H2AB2;H2AB3;H2AB1 EZH2 HLA-DPB1-1 PRKAG1 PRKAG2 CD3G ASH2L MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 TEAD3 HLA-DPA1 TEAD4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FOS PDCD1LG2 VAV1 H2AJ PVR B3GNT3 CSNK2A1;CSNK2A3 AGO3;AGO1 DERL3 DERL1 DERL2 PAK1 OS9 SPOP RICTOR PAK3 CD14 PAK2 BRD4 SUZ12 H2BC5 STAT1 STAT3 MIB2 H2BC1 FOSB VCP-1 CD86 TUSC3 CD80 LOC102723996;ICOSLG NECTIN2 GRAP2 MAP3K8 NEK2 IFI30 H2AC4 MYCN TMEM258 CD274 KMT2A ICAM1 KMT2C KIFAP3 TCF7 SEL1L BTLA THEM4 TNFRSF14 ITGB2 OST4 NFKB2 COPS5 ICAM4 ICAM5 OSTC STT3A HLA-DRA STT3B MAP3K14 RNF185 ITGB7 PRR5 GSK3B DPY30 PIK3CD PIK3CB PIK3CG KIF3B H2BC21 WDR5 KIF3A MLST8 IFITM3;IFITM2;IFITM1 YWHAG EED PDPK1 VCAM1 H2AZ2;H2AZ1 DDOST PIK3CA KIF3C DAD1 BTNL9 BTN3A1;BTN3A3 LCK BTN1A1 IRF1 PRKAA1 BTNL2 PRKAA2 BTN2A2;BTN2A1 LEF1 HLA-DQB2;HLA-DQB1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN CSK RBBP7 TCF7L2 TCF7L1 TNRC6A-1 PTPN11 MTOR TNRC6C CD4 H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 PDCD1 TNRC6B ACTR1A ELOC-1 ELOB DCTN2 DCTN3 FBXO4 FBXO6 FBXW4 FBXW10;CDRT1 FBXW5 CD22 FBXW7 FBXW9 FBXW2 SOCS3 S100A9 S100A8 FBXO32 FBXL3 FBXL5 ICAM2 ICAM3 CLEC4M;CD209-2 PTEN ITGB1 ITGAL TRIM63 ITGA4 RAP1GAP2 SIPA1 HLA-DOA HLA-DOB LAG3 KIF20A KLC1 KLC4 KLC3 KLC2 OSBPL1A KIF11 KIF15 CTSO ACTR1B CALR-1 CTSH CTSF VAMP3 CTSE KIF23 RAB7A KIF22 HLA-DMA HLA-DMB RILP CD74 KIF26A CXADR JAML TRAT1 PIK3AP1 CD99 SELL TREM1 CTSK ITGB5 CD300LF;CD300LD KIF5B SIGLEC10;SIGLEC11;SIGLEC16 KLRC4-KLRK1;KLRK1 KIF5A LAIR1;LAIR2-1 CD96 PIANP ITGAV SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 CLTC CLTA OSCAR CD8A ULBP1-2 CD300E NCR3LG1-1 CTSD CD226 HCST CLEC4G NCR1-1 CUL2 CD1D CD1C CANX CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 SLAMF6 VASP LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG KLRG1 NPDC1 SIGLEC5;SIGLEC14 SEC61A2 MRC2 KLRB1-1 KLRC4;KLRC3;KLRC2;KLRC1 SEC61A1 CD160 SEC61G SEC61B CRTAM TAP2 SH2D1A TAP1 NCK1 SH2D1B PILRA;PILRB TAPBP TREML1 STX4 CD207 CD40LG TREML4 ENAH TREML2 BLK CAPZB KIF4B;KIF4A EVL KLRD1 SIGLEC1 RAET1E-1 CD200 DNM1 DNM3 CAPZA1 CAPZA2 PAG1 RNF111 SPTBN2 NEDD4L PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 CTSA PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PRKCB FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 UBE2D3-1 RELA PSMA7 MALT1 PSMB6 ARF1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 DNM2 VAMP8 PSMC3 PSMC4 PSMC1 REL NFKBIE NFKBIB TRPC1 WWP1 PIK3R4 AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 B2M AP1M2 PIK3C3 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSME1 PSME2 PSMB10 LRR1 PSMB8 CCNF PSMB9 KEAP1 CBLB UBE2L6 DCAF1 HERC5 HERC4 CDC34 ITK TRAF6 HERC3 RNF115 PRKCQ FYB1 RNF114 UBE2V1 ZAP70 LCP2 HERC2 RASGRP2 LAT HERC1 UBE2D3;UBE2D2 FBXO7 CD101 TRIM21 UBE2N FBXO9 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs ALOX5 PTGS2-2 ALOX15 ALOX12 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 HEXA SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) MC4R EDNRB EDN1 EDN3 MC3R POMC MC1R MC5R CGA C5AR2 TSHB C5AR1 MCHR1 NPY OPRM1 OPRK1 SSTR3 RXFP4 RLN3 RLN2;RLN1 INSL3 RXFP1 APP INSL5 RXFP2 RXFP3 CCR5 MRGPRD CMKLR1 ADRA1D PDYN ADRA1B AGTR2 ADRA1A FPR1 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 GPR37 GPR35 CXCL2;CXCL3;CXCL1-1 RGR PLPPR1 CCL11 PLPPR2 PLPPR3 TBXA2R PLPPR4 PLPPR5 CCL4L2;CCL4L1;CCL4 CCL19 OPN1SW GPHA2 CCL17 CCL16 CCL25 P2RY12 P2RY13 CCL22 CCL21 CX3CR1 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B CCL3L1;CCL3L3;CCL3;CCL18 PSAP CXCL10 CXCL11 CHRM2 ECE1 CHRM3 PRLHR CHRM1 ADORA2A CHRM4 P2RY4 CHRM5 CCL5 HTR2B CCL1 ADRB1 APLN ECE2;EEF1AKMT4-ECE2 ADRB2 RRH HTR2A HTR4 CXCL5;CXCL6 HRH1 HTR6 PTGDR HTR7 GPR37L1 HRH3 KEL HRH2 HRH4 DRD1 DRD2 LHB DRD3 SST NLN DRD4 MC2R DRD5 TAAR8 PENK PPY HTR1E CCR10 HTR1F TAAR9 CCR1 TAAR6 PPBP HTR1D HCAR2;HCAR3 HTR1A TAAR5 ACKR3-2 PTGDR2 HTR1B TAAR2 NPY4R2;NPY4R CX3CL1 HTR5A TAAR1 CCR9 CCR8 GPR143 CCR7 ADRB3 CCR6 CCR4 CCR3 CCR2 OXGR1 FSHB GPBAR1 GAL FSHR OPN1MW3;OPN1MW2;OPN1MW;OPN1LW OPRD1 PTGER4 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH CYSLTR1 MAS1 CYSLTR2 XK C3AR1 NPY2R CCRL2 NPY1R APLNR SUCNR1 HCAR1 OPN3 OPN5 PYY CXCL9 HEBP1 ANXA1 GPER1 PTGIR NPY5R SSTR1 SSTR2 SSTR4 SSTR5 OPRL1 CNR2 CNR1 S1PR3 ADORA2B S1PR1 S1PR2 S1PR5 S1PR4 TSHR CXCL12 ACKR4 ACKR2 ACKR1 CENPS-CORT;CORT;CENPS CXCR4 CXCL8 NPFFR2 NPFFR1 GRPR EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 OXTR NMS NMU AVPR1B GNRH1 AVPR2 QRFP AVP MLN AVPR1A BRS3 OXT-1 GPR132 CCKAR GNRHR FFAR4 FFAR2 FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR CCL13;CCL2 NPS PROKR1 PROKR2 KISS1R P2RY10 C5 P2RY11 ADRA2C GPR4 ADRA2B C3-1 AGT ADRA2A F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR F2R LTB4R2 NTS PF4;PF4V1-1 MCHR2 KNG1 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R BDKRB2 BDKRB1 QRFPR P2RY6 P2RY2 P2RY1 RHO CCK HCRTR2 HCRTR1 KISS1 SAA2;SAA1 FFAR3;GPR42 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes ATP6V1C1 ATP6V1C2 ATP6V0A1 ATP6V1F HVCN1 ATP6V0E2;ATP6V0E1 NCF1 NCF2 NCF4 CYBB CYBA TCIRG1 LPO SLC11A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B NOS2 NOS3 ATP6V1G2 NOS1 ATP6V1B2 ATP6V0D1 ATP6V0D2 MPO ATP6V0C ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery RPS4X SNRPG-2 RPS15 RPS3A RPS14 RPS17 RPS16 RPS27L RPS19 RPS15A RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 FAU RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS27 RPS27A GEMIN2 SNRPD2 SNRPD1 SNRPD3 RPS25 RPS29 SMN2;SMN1 RPS20 GEMIN4 GEMIN5 RPS21 GEMIN6 RPS24 SNRPF RPS23 GEMIN7 GEMIN8 SNRPB DDX20 SNRPE-2 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters CLOCK ARNTL CREBBP KMT2A EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling RAC1 ARHGEF7 SDCBP EPHB6 EPHB1 EPHB4 MYL12A EPHB3 PAK1 PAK3 NCK2 PAK2 GIT1 FYN EPHB2 EFNB2 EFNB1 EFNB3 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GNS GLB1L GLB1 FMOD GALNS OGN KERA OMD PRELP ACAN HEXB HEXA LUM GLB1L3 GLB1L2 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 CBLIF CUBN AMN TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 TEAD1 TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SPP1 PSMD7 PSMD2 PSMD3 CCN2 PSMD1 CDKN2A PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 FOXO3 PSMD12 PSMD11 PSMD14 PSMD13 BCL2L11 SNW1 PSMA7 PSMB6 JAG1 PSMB7 PSMB4 PSMB5 BRD2 PSMB2 PSMB3 RUNX3 SRC PSMB1 CDKN1A RPS27A TGFB1 KAT2B UBB;UBC KAT2A TCF7 ADRM1 NOTCH1 PSMA2-1 CCND1 TP53 SEM1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RBPJ HDAC4 MAMLD1 LEF1 SMAD2;SMAD3 SMAD4 ZFHX3 SMURF2 MYC SMURF1 YAP1-1 ITGAL TCF7L2 TCF7L1 MDM2-2 CBFB RUNX1 ITGA4 WWTR1 KRAS MAML2 HES1 MAML1 EP300 CREBBP FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation FGF4 FGF9 FGF20 FGF23 FGF16 FGF18 GALNT3 FGF1 FGF2 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism PRXL2B PTGR2 PTGS1 FAAH2 HPGD LTA4H AWAT1 CYP2J2-1 CYP2C9;CYP2C19 FAAH PLA2G4A PTGES LTC4S ALOX15B PTGIS CYP1A2 TBXAS1 CYP1A1 CYP8B1 CBR1-1 PON3 PON2 GGT1 PON1 EPHX2 DPEP2 DPEP1 CYP2U1 HPGDS CYP1B1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GGT5 ALOX5 PTGS2-2 PTGES3-1 GPX1 MAPKAPK2 GPX4 ALOX12B ALOXE3 ALOX12 PTGDS ABCC1 ALOX15 CYP4B1 CYP4F22 ALOX5AP PTGR1-1 PTGES2 SLC27A1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling HBEGF HRAS PRKCA PTPN12 EGFR PRKCE ERBB2 NRG2 NRG3 SOS1 NRG4 SHC1-1 PRKCD EGF NRG1 EREG BTC NRAS MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease BCKDHB DBT DLD PPM1K BCKDHA PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines PAOX DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA CBL GAB1 SOS1 SHC1-1 PLCG1 EGF NRAS MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L NCBP2-1 RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters SRI SLC39A2 SLC39A1 SLC39A3 CP SLC8A3 CALM3;CALM1 SLC9A2 SLC9A3 SLC9A4 SLC24A2 SLC9A5 SLC24A3 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC39A4 SLC40A1 SLC8B1 HEPH SLC11A1 SLC8A1 SLC30A10 SLC8A2 SLC24A1 SLC24A4 SLC11A2 SLC39A10 SLC39A14 SLC24A5 SLC31A1 SLC30A3 SLC30A2 SLC39A6 SLC30A8 SLC30A1 SLC41A2 SLC39A5 SLC41A1 SLC39A8 SLC30A5 SLC39A7 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions PTPN11 INPP5D PTPN6 PECAM1 ITGB3 PLCG1 LYN FYN YES1 LCK ITGAV RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR2E POLR3E POLR2F POLR1C POLR3F POLR2H POLR1D POLR3G POLR2L POLR3H BDP1 POLR3K GTF3C1 GTF3C2 GTF3C3 CRCP TBP GTF3C4 GTF3C5 BRF1 POLR3GL GTF3C6-1 POLR3A POLR3B POLR3C POLR3D G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 BTK GNG13 GNGT1 GNG10 GNB2 GNG2 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling JAK2 TYK2 JAK1 GSTA3;GSTA5;GSTA1;GSTA2 RALA-1 PPIA HNRNPF HSPA9 CDC42 TALDO1 PAK2 SOD2 LMNB1 SOD1 CFL1 CA1 HNRNPA2B1 ARF1 CAPZA1 PSME2 IL12B IFNG PITPNA IL12A TCP1 SERPINB2 AIP MIF SNRPA1 LCP1 CNN2 HNRNPDL IL10 STAT4 IL12RB1 VAMP7 IL12RB2 MTAP PDCD4 RPLP0 MSN ANXA2 GSTO1 P4HB RAP1B SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation NADK2 ME2 TIMM22 MRPL32 PDK1 SHMT2 ATP5F1A PDHA1 TIMM10 ATP5F1B ATP5MG PRELID1 HSPA9 ATP5PF ATP5PD ACAD8 MRPS2 ATP5F1C FH ACADSB ECH1 ATP5PO ALDH2 IARS2 NDUFA13 ALDH1B1 STAR SPG7 AFG3L2 ARG2 SMDT1 ACOT2;ACOT1 PRKACA-1 YME1L1 NDUFV3 PMPCA NDUFV1 MICU2 IDH2 COX5B COX5A MRPL12 IDH3A PCCB UQCRQ NDUFS1 UQCRC2 NDUFB6 HTRA2 HADH LONP1 TFAM-1 ALAS1 FECH OXSM COX4I1 CLPX BDH1 OXCT1-1 CLPP HMGCS2 ALDH18A1 GLUD1;GLUD2 ACAT1 DBT DLD TIMM17A-1 CHCHD2 SLC25A5 HSD17B10 SLC25A6 TWNK HSPD1 LDHD PDHB SSBP1 OMA1 CS NDUFS3 OPA1 ACO2 ECI1 STARD7 MDH2 MRPS10 SUCLG2 OGDH SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 MAP2K5 MAPK7 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle POLD2 RBBP8 ATRIP BARD1 RPA1 BRCC3 RPA2 CLSPN TP53BP1 POLE4 RAD50 BABAM1 YWHAH RAD51 BABAM2 UIMC1 RPA3 LBR ABRAXAS1 POLE2 RNF8 POLE3 RAD17 RNF168-1 NSD2 ATM RAD1 RAD9B RAD9A ATR ANAPC15 FBXL7 ANAPC16 YWHAZ ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 HDAC1 CCNB1 CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SET-1 SPO11 PSMC3IP MND1 TPX2 MLH3 MSH4 DMC1 MSH5 YWHAB MAPK1 PPP6C PPP6R3 MAPK14 HSP90AB1 UBE2V2 MAPK11 NPM1-2 GORASP1 RAB1A RAB1B USO1 ANKRD28 RBL2 GINS1 RBL1 GINS2 CDC45 MCM7 GINS3 XPO1 GINS4 MCM3 MCM4 MCM5 EP300 MCM6 MCM2 JAK2 GTSE1 FKBPL HJURP RSF1 MIS18BP1 OIP5 CENPW CENPX MIS18A YWHAE CDC25C CDC25A FBXL18 LMNB1 CDC25B GOLGA2 PHLDA1 RBX1 ARPP19 NCAPH2 NCAPG2 NIPBL ENSA NCAPD3 RAB2A CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL GORASP2 MCPH1 CDC6 CHMP4C CHMP4B CHMP3 CHMP4A ESCO1 ESCO2 CHMP6 PTK6 CHMP7 LIN54 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 SUN2 CHMP2B CHMP2A PRIM2 PRIM1 POLA1 POLA2 SMARCA5 DSCC1 RUVBL2 SHQ1 PIF1 CTC1 CHTF18 STN1 TEN1 RB1 CDKN1C PRKACA-1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 PRKAR2B E2F3 SKP2 DAXX ATRX TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC FOXM1 PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A TINF2 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 MDM2-2 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 ACD RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 LIG1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B MDM4 PPP2R5A PPP2R5D PPP2R5C RANGAP1 CCNA2-1 SMC1A CKAP5 KIF2A INCENP TERF2 BIRC5 KIF2C CCNA1 POT1 KIF2B TERF2IP ITGB3BP PAFAH1B1 NEK9 DYNC1I2 CENPA NEK6 NEK7 AURKB NSL1 TOP2A CENPC NUP43 BUB3 CDKN2D BUB1 CDKN2B DYNC1I1 CLASP1 CDKN2C CLASP2 CENPT CDKN2A RANBP2 DYNC1H1 TERF1-1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 MLH1 HMMR CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L CDK7 POLR2J;POLR2J2;POLR2J3 MNAT1 H2AC14 AKT2 MYC AKT3 AKT1 CSNK2A2 CSNK2B PHF20 CHEK2 ZNF385A COP1 PCBP4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN H2AC20 H2AB2;H2AB3;H2AB1 PPP1R12A H2AJ CSNK2A1;CSNK2A3 OPTN-1 AKAP9-1 H2BC5 H2BC1 NEK2 H2AC4 CCP110 CEP250 CDK5RAP2 CEP135 CSNK1D MDC1 GSK3B H2BC21 YWHAG PRKCA CEP70 CEP72 H2AZ2;H2AZ1 CEP192 HSPA2 CEP76 CEP78 EML4 PLK4 ODF2 SFN RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CEP57 CETN2 CEP164 H2BC15;H2BC3;H2BC11;H2BC12 SPAST VPS4A CC2D1B SIRT2 IST1 VRK1 ACTR1A LEMD2 ESPL1 CNTRL TNPO1 CEP290 RAB8A TERT HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 SYCP1 SYNE2 SYNE1 SUN1 TEX12 SMC1B SYCP3-2 SYCE2 CEP63 SYCE1 FKBP6 REC8 STAG3 PTTG1;PTTG2 SYCP2-1 TUBA1C TUBA1A DCTN2 CENPJ SSNA1 TUBB1 DCTN3 HAUS8 HAUS7 RCC1 PCNT OFD1-1 CEP152 TUBB2B;TUBB2A NEDD1 KMT5A ALMS1 TUBA4A CEP41 CEP43 DYRK1A TP53 TK1 DHFR2;DHFR TUBB3;TUBB6 TYMS SMC4 TUBAL3 PPP2R3B SMC2 TUBGCP2 MZT2A;MZT2B NCAPG NCAPH MAX TUBGCP5 TUBGCP6 TUBGCP3 TUBA3E;TUBA3C-1 TUBGCP4 NUMA1 TUBG2 NME7 MZT1 NCAPD2 TUBB4B CSNK1A1 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E NEK11 TUBA8 WRAP53 NUP205 NUP188 AAAS NUP42 NUP62 TPR BANF1 NUP88 RAE1 NDC1 ANKLE2 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 ORC5 EMD ORC4 ORC6 ORC1 MCM8 ORC3 KIF20A ORC2 LEMD3 E2F5 E2F6 KIF23 PKMYT1 PPP1CB KPNB1 FBXO5 LPIN1 LPIN2 LPIN3 PPP2R2A;PPP2R2D HSP90AA1 RAN AJUBA YWHAQ MYBL2 AURKA CDK11A;CDK11B PPME1 BORA OBI1 LCMT1 TICRR PRDM7;PRDM9 E2F4-1 PSMD8 PSMD6 PLK3 PSMD7 PSMD2 PSMD3 PSMD1 BTRC CDC7 SKP1 PRKCB FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 RRM2-1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RUVBL1 PIAS4 UBE2I SUMO1 MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN DKC1 TOPBP1 POLE NHP2 RFC5 RMI2 GMNN CDC14A RFC3 RFC4 RFC1 RMI1 CDT1 RFC2 FEN1 MCM10 TOP3A HUS1 ABL1 DBF4 RAD51C DNA2 RHNO1 RTEL1 BLM C1orf112 NOP10 PCNA POLD3 POLD4 WRN HERC2 BRIP1 FIGNL1 UBE2N POLD1 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle NUP107 NUP160 RAN NUP85 TSG101 VPS4B VPS4A MVB12B CCNK MVB12A CCNT1 VTA1 ELL GTF2B VPS37C ELOC-1 VPS37D TAF7L VPS37A ELOA XPO1 ELOB VPS37B NELFB UBAP1 NMT2 NELFA SEC13 VPS28 NELFCD NELFE NUP133 CHMP5 SUPT16H TBP FURIN NCBP1 GTF2A1 RANGAP1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 NEDD4L CCNT2-1 NUP43 TAF8 TCEA1 TAF4B TAF7 PPIA TAF6 TAF5 TAF4 RANBP2 TAF3 TAF2 TAF1 UBA52 RCC1 NMT1 NUP37 RANBP1 RPS27A UBB;UBC GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 NUP205 NUP188 PDCD6IP AAAS NUP42 NUP62 TPR NUP88 CHMP4C RAE1 CHMP4B NDC1 NUP214 CHMP3 NUP210 CHMP4A NUP155 NUP153 CHMP6 NUP93 CHMP7 NUP50 POM121;POM121C NUP35 NUP54 CHMP2B CHMP2A IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DLST DHTKD1 DLD CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition PPP2R2A;PPP2R2D HJURP FOXM1 PPP2R1B MIS18BP1 PPP2R1A SGO1 CDK7 MNAT1 CDC25C PLK1 PKMYT1 CDC25A CCNB2 CDC25B CCNB1 CDK1 PPP2CB;PPP2CA WEE1 XPO1 FZR1 PPME1 BORA PPP2R3B OBI1 LCMT1 CCNA2-1 TICRR CCNH CCNA1 CDK2 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle TRAK1 RAP1GDS1 MYO19 TRAK2 RHOT1 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation CSF1 PENK PCSK9 PRKCSH MGAT4A-1 KTN1 APOA2 SERPINC1 APOE APOA5 VCAN MFGE8 CST3 HSP90B1 ANO8 TNC ALB P4HB FBN1 SERPINA1 DNAJC3-1 CALU F5 QSOX1 AHSG SPP2 SDC2 IGFBP7 APLP2 SCG3 TIMP1 IL6 APOB CDH2 APOA1 LTBP1 FGA FGG SPP1 DMP1 LGALS1 AMELY;AMELX EVA1A CCN1 APP CHGB IGFBP5 IGFBP4 GPC3 SHISA5 MXRA8 SPARCL1 VGF SCG2 STC2 CHRDL1 AMBN FSTL1 FUCA2 TMEM132A BPIFB2 ADAM10 HRC MELTF MIA3 MSLN PRSS23 BMP15-1 MEPE RCN1 APOL3;APOL4;APOL1;APOL2 ENAM AMTN VWA1 FAM20C FAM20A MATN3 ITIH2 MBTPS1 AFP FSTL3 SERPIND1 GOLM1 NUCB1 NOTUM PDIA6 PNPLA2 CP C3-1 LOC110384692;C4A;C4B_2;C4B TF LAMB2 FN1 LAMB1 WFS1 PROC LAMC1 MEN1 TGOLN2 FGF23 IGFBP1 IGFBP3 KNG1 BMP4 CKAP4 GAS6 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism ACOT9 ACOT7 FADS2 MCAT FADS1 PRXL2B PTGR2 PTGS1 THEM5 FAAH2 SCD5 AWAT1 SLC25A20 CPT1A MID1IP1 FAAH ACAD11 ACAD10 CPT1B PTGES PLA2G4A ALOX15B LTC4S PTGIS TBXAS1 CYP8B1 CBR1-1 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 ACSF2 CPT2 PON3 ELOVL3 PON2 GGT1 PON1 DPEP2 DPEP1 THEM4 MCEE CYP2U1 PCCA CYP1B1 MMAA CYP4F3;CYP4F2;CYP4F12;CYP4F11 PCCB MMUT GGT5 ACBD4 ACADVL PTGES3-1 PRKAA2 ACBD5-1 MAPKAPK2 ALOX12 NDUFAB1 HACD1 TECR HSD17B3 HSD17B12 HACD3 HSD17B8 HACD2 HACD4 MORC2 FASN CBR4 ELOVL1 ACOXL OLAH ELOVL4 ELOVL2 ACSL6 ACSL5 ACSL4 ACSL3 ECI1 ELOVL7 TECRL ACADM DECR1 ACSF3 ACLY PPT1 ACSBG1 PPT2 SLC27A3 PPARD ACSBG2 MECR HADHA HADHB-1 HPGD LTA4H ACADL PECR CYP2J2-1 CYP2C9;CYP2C19 CROT SCP2 NUDT19 CYP1A2 CYP1A1 ACOX2 ACOX3 ELOVL6 PHYH-4 HACL1 ACOT2;ACOT1 EPHX2 ACSL1 NUDT7 AMACR ACACA CRAT HPGDS ELOVL5 SCD ALOX5 PTGS2-2 THRSP ECHS1 ACSM3 HADH ACADS RXRA GPX1 ACOT8 EHHADH-1 PRKAB2 ACAA1-1 HSD17B4 DECR2 ABCD1 GPX4 SLC27A2 ALOX12B ACOT4 ALOXE3 PTGDS ABCC1 ALOX15 SLC25A17 CYP4B1 CYP4F22 ALOX5AP PTGR1-1 PCTP PTGES2 SLC27A1 PRKAG2 SLC22A5 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type VCAN AGRN CSPG5 CSPG4 B4GALT7 SDC1 GPC1 HSPG2 GPC3 NCAN BGN GPC2 SDC4 GPC5 SDC2 DCN GPC4 SDC3 BCAN GPC6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 PLK1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CCNB1 CDC23 PSMD13 MAD2L1 CUL1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 FBXO5 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDK2 BUB1B CDC20 CCNA2-1 CCNA1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation TAB2 TAB1 LRRC14 USP14 NLRX1 IKBKB NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 IKBKG N4BP1 CASP8 MAP3K7 IRAK1 CHUK USP18;USP41 APP TRAF2 UBA52 RELA HMGB1-1 RPS27A RIPK2 UBB;UBC NFKB1 TP53 NFKBIA NFKB2 SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 TIFA IKBIP UBE2V1 ALPK1 NFKBIB UBE2N TAB3 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization HSD17B13 CIDEC CIDEA FITM1 FITM2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity CACNG8 CAMK2G CACNG2 CACNG3 DLG1 PRKCA CACNG4 DLG4 AP2A1 PRKCB MYO6 GRIP1 NSF MDM2-2 PRKCG GRIP2 GRIA1 AKAP5 EPB41L1 TSPAN7 GRIA3 GRIA4 CAMK2B CAMK2D CAMK2A GRIA2 PICK1 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression MOV10 SRF AGO4 TNRC6C KCNIP3 AGO2 NPAS4 NR3C1 TNRC6B REST TNRC6A-1 AGO3;AGO1 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair MSRB3 TXN MSRA PCMT1 MSRB2 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint RBBP8 ATRIP BARD1 RPA1 BRCC3 RPA2 TP53BP1 BABAM1 YWHAH RAD50 BABAM2 UIMC1 RPA3 ABRAXAS1 RNF8 RNF168-1 RAD17 NSD2 ATM RAD1 RAD9B YWHAE RAD9A ATR YWHAZ CDC25C H2BC5 CCNB1 H2BC1 CDK1 TP53 MDC1 YWHAB PIAS4 H2BC21 YWHAG UBE2V2 SFN MRE11 BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 EXO1 CHEK1 NBN TOPBP1 YWHAQ CHEK2 RFC5 H2BC15;H2BC3;H2BC11;H2BC12 RMI2 RFC3 RFC4 RMI1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RFC2 TOP3A HUS1 WEE1 DNA2 RHNO1 BLM CCNA2-1 HERC2 WRN BRIP1 CCNA1 UBE2N DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD CBLIF REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate POLD2 RPA1 RPA2 FEN1 RPA3 DNA2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis NCOR1 NR1H2 RXRB NCOA1 NR1H3 FABP6 NCOR2 RXRA LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 HAUS8 HAUS7 PCNT OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP250 CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CEP57 CETN2 CEP164 ACTR1A MAPRE1-1 CNTRL CEP290 CKAP5 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2A YY1 TFAP2C CGA TGFA ESR1 EGFR TFAP2E;TFAP2B VEGFA KIT ATAD2 ERBB2 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein PARP9 UBE2I PARP14 PARP8 PARP10 CSNK1A1 SUMO1 SRPK2 GSK3A SRPK1 PARP6 PRMT1 PARP4 GSK3B PARP16 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35B3 SLC35B2 SLC35D1 SLC35A2 SLC35C1 SLC35A3 SLC35B4 SLC35A1 SLC35D2 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3L3 MBTPS2 DCSTAMP CREBRF CREB3 MBTPS1 CREB3L4 CREB3L1 CREB3L2 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 STOML2 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB MICU3 PMPCA MICU2 MICU1 MCU PHB EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma HBEGF TGFA EGFR PLCG1 EGF AREG EREG BTC EPGN PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis IRF1 CASP1 TP63 GZMH;GZMB-1 IL18 IL1A IL1B IRF2 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 CYCS-1 HMGB1-1 BAK1 ELANE CASP3 GSDMD TP53 CASP5;CASP4 CHMP2B CHMP2A BAX GSDME BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations PTGS1 AOC1 TPST2 TPST1 ADH4 PTGIS ADH1C;ADH1B;ADH1A TBXAS1 ACSS2 CYP8B1 ALDH2 ALDH1B1 ACSS1 ADH5 POMC CES3 GGT1 DPEP2 DPEP1 CYP2U1 CYP1B1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 TPMT GGT5 GSTM1;GSTM2-1 CES1 GSTA3;GSTA1 UXS1 ARNT2 FMO2 FMO3 GSTA3;GSTA5;GSTA1;GSTA2 CYP4V2 PTGES3-1 HSP90AB1 MAOA CYP26A1 CYP26B1 CYP24A1 CYP21A2 CYP11B1;CYP11B2 SLC35D2 SULT1C2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 BPNT2-1 PODXL2 ABHD14B BPNT1 SULT6B1 SULT2A1-4 SULT4A1 SULT1B1-1 AIP NCOA1 NCOA2 CYP19A1 AKR1A1 CYB5R3 GGT7 ACY3 GGT6 MGST3 MAOB MGST1 MGST2 AKR7A2 AKR7A3 CYP2D6;LOC107987479;LOC107987478-1 CYP2J2-1 CYP2C9;CYP2C19 GLYATL3 CYP2C18-1 ACSM5 AHR ACY1;ABHD14A-ACY1 GLYAT CYP2W1 ACSM4 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 GSTK1 CYP2S1 CYP1A2 CYP1A1 AHRR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP2F1 PAOX CYP2R1 GSTT1 FMO1 OPLAH BPHL CNDP2 CBR3 HPGDS N6AMT1 ESD AADAC MTRR CHAC2 ACSM1 CHAC1 AHCY CYP51A1 NNMT GSTM4 ACSM2A;ACSM2B GSTM3 GSTO1 AOC3 MTR-1 GSTO2 AOC2 CMBL MAT1A GSTT2B;GSTT2 MTARC2 GGCT MAT2B COMT MTARC1 GSTZ1 TRMT112 GSTA4 AS3MT NQO2 CYP27A1 MAT2A ALDH3A1 GCLC EPHX1 NR1H4 CYP7B1 GSS GCLM CYP7A1 RXRA FDX1 FDXR GSTP1 CES2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABHD10 UGT2A1 UGT1A1;UGT1A6 CYP46A1 UGDH CYP39A1 SLC35D1 POR NAT1 CYP27B1 ALDH1A1 ARNT CYP4B1 CYP4F22 CYP11A1 UGP2 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A7A;S100A7 S100A9 S100A8 LCN2 LTF HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels HCN4 HCN3 HCN2 HCN1 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants HRAS NRAS KRAS PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis SRI ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 CALM3;CALM1 P2RX7 P2RX4 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 TRPC7 P2RX6 ITPR1 TRPC6 P2RX5 ITPR2 TRPC3 P2RX3 P2RX2 P2RX1 ITPR3 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) SOCS3 JAK2 TYK2 JAK1 SYK RNF7 HCK CUL5 SHC1-1 GAB2 SOCS1 UBA52 UBE2D1 STAT1 STAT3 PTPN11 UBE2D3-1 CSF3 CSF3R LYN ELOC-1 RPS27A UBB;UBC KRAS ELOB STAT5A STAT5B GRB2 UBE2D3;UBE2D2 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases TAB2 RPS6KA1 SIN3A HDAC2 PTK2B PRKCD KIT HDAC1 ID1 SH3GL3 SH3KBP1 SRC NEDD4 CAV1 CTNND1 STAM CBL GRB10 PGF INSR HGS CTNNB1 STAM2 MET SPARC EPS15 SH3GL2 SH3GL1 SHC2 VAV3 SHC3 INS;INS-IGF2 RALB STAT6 YWHAB CRKL NRAS RAP1A MAP2K2;MAP2K1 MAPK1 RALGDS VAV2 PDGFB HRAS MAPK3 NTRK1 KIDINS220 BRAF FRS2 PTPRO MAPK14 RALA-1 NGF RNF41 ADAM12 MAPK12 MAPK13 MAPK11 ROCK1 RIT1 CUL5 ROCK2 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK SHC1-1 SOCS1 VEGFB VEGFC VEGFD ATF2 CDC37 HDAC3 EPS15L1 EPN1 ARF6 THBS1 ERBB2 EP300 ANOS1-1 FURIN PCSK6 MEF2D PCSK5 ITGB3 PLG MEF2C AAMP BCAR1 RAP1B JAK2 NCOR1 MATK PRKCE GRB7 FGFRL1 CALM3;CALM1 FAM83B IDE TIAL1 TIA1 RBFOX2 CDK5 ESRP2 TCIRG1 ATP6V1E1 CDK5R1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 JUP ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A DIAPH1 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1C2 ATP6V0A1 HGF ATP6V1F FGFBP1 FGFBP3 ARHGEF7 DLG4 ATP6V0E2;ATP6V0E1 ADCYAP1 NCKAP1 WASF1-1 NCF1 NCF2 ADCYAP1R1 NCF4 PTPN3 CYBB CYBA KDR PTPRJ PTK6 NCKAP1L WASF2 BAIAP2 ABI2 ABI1 ITCH MMP9 COL4A2 BAX DNMT1 STUB1 COL4A1 COL6A2 PDGFRA COL4A4 COL6A1 COL4A3 COL9A1 PSENEN PSEN2 PSEN1 APH1A COL6A3 NCSTN COL4A5 SPRED2 APH1B HNRNPM COL9A3 SPRED1 COL6A6 COL6A5 HNRNPF COL9A2 RASA1 ELMO1 HNRNPA1-1 AP2A1 AP2A2 AP2M1 CYFIP2 AHCYL1 CTNNA1 PRKACA-1 PTBP1 PRKACB-1 AP2S1 AP2B1 ITPR1 ITPR2 JAK3 ITPR3 FLT3 PPP2R1B HNRNPH1 PPP2R1A RPS6KA3 RPS6KA2 WASF3 PPP2CB;PPP2CA IL2RG PPP2R5D DOCK7 TNS4 TNS3 MAPK7 HSPB1 NTRK2 DOCK3 BDNF GAB1 GRIN2B FRS3 PTPN18 NTF4 TIAM1 NTF3 PLCG1 EGF AREG RAB4B PTPN2 SPINT1 HPN MST1 SPINT2 MST1R ADAM10 ADAM17 GABRB3 GABRB2 GABRB1 GABRG3;GABRG2 NRG1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 GABRQ GABRA1 POLR2J;POLR2J2;POLR2J3 AKT2 MYC AKT3 AKT1 TRIB3 MAPKAP1 AXL PIK3R3 PIK3R2 PIK3R1 ID4 HIF1A LYN JUND YES1 ATF1 DUSP4 MEF2A DUSP3 VRK3 DUSP6 DUSP7 RAC1 FOS VAV1 PTPRZ1 CDH5 PAK1 RICTOR PAK3 PAK2 STAT1 STAT3 ESRP1 FOSB FLT3LG GRAP2 MYCN CD274 THEM4 LTK TNK2 EGR1 PRR5 PTN ALKAL2 PIK3CB ALKAL1 EGR2 MLST8 PRKCA PDPK1 PIK3CA LCK ALK CDC42 YAP1-1 FYN CSK PTPN11 MTOR PTPN6 NELFB GGA3 MEMO1 NRG2 NRG3 NRG4 NCBP1 PXN RAB4A NCBP2-1 EGFR FLT4 MDK SPP1 NAB1 NAB2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 GFAP ID3 DNAL4 ID2-1 LYL1 F3 VGF ASCL1 IRS4 IGF2 CDK5R2 IGF1 SPHK1 PLAT SOCS6 PDGFD CILP CSN2-1 MXD4 PRKCZ RHOA THBS4 THBS3 STMN1 ADAP1 RPS6KA5 ITGB1 CYFIP1 MKNK1 IGF1R SPRY2 HGFAC SHB NOS3 ADORA2A SRF ELMO2 PTPN1 DOCK1 ERBIN PDGFRB NTRK3 PTPRU SH2B3 SH2B2 CMA1 TGFA FER TEC FES GRAP APOE RANBP10 STAT5A STAT5B GRB2 VEGFA ITGAV CLTC CLTA PTK2 PRDM1 CTSD HSP90AA1 PTPN12 FLRT3 CXCL12 NRP2 NRP1 NCK2 NCK1 CHD4 DNM1 DNM3 PTPRK LRIG1 FAM83D PAG1 FAM83A SPRY1 THBS2 REST TGFBR3 GIPC1 SGK1-1 JUNB RANBP9 GALNT3 MUC20 USP8 FLRT2 FLRT1 PRKCB ELK1 UBA52 EREG BTC EPGN HBEGF TCF12 RPS27A UBB;UBC DNM2 PTPRS PTPRF WWOX WWP1 ESR1 KLB LAMA5 IRS1 LAMB3 PDE3B LAMA2 PIK3R4 LAMB2 IRS2 LAMA1 FGF1 LAMC3 FGF2 LAMA4 FGF3 LAMA3 FGF4 FGF6 LAMB1 FGF7 LAMC2 FGF9 PGR LAMC1 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 CHEK1 FGFR4 FGF10 ITGA3 ITGA2 FLT1 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET RAC1 MUC20 USP8 GAB1 UBA52 STAT3 RAB4B PTPN2 SPINT1 HPN SPINT2 SH3GL3 SH3KBP1 SRC RPS27A UBB;UBC STAM RANBP10 CBL HGS STAM2 MET EPS15 SH3GL2 SH3GL1 CRKL NRAS RAP1A PTK2 HRAS HGF LAMA5 LAMB3 PIK3CA LAMA2 LAMB2 LAMA1 LAMC3 LAMA4 LAMA3 LAMB1 LAMC2 RAPGEF1 LAMC1 SOS1 CRK ITGB1 HGFAC PTPN11 ITGA3 PTPRJ ITGA2 PIK3R1 LRIG1 ARF6 GGA3 DOCK7 TNS4 TNS3 PTPN1 RAB4A RANBP9 RAP1B ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 PTPN11 BDNF HRAS SOS1 FRS3 NTF4 FRS2 NRAS INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane OTOF UBL4A STX5 BAG6 SGTA EMD VAPA HMOX1 APP SEC61G SEC61B PRNP GET1 GET3 STX1A VAMP2 GET4 CAMLG POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere POLD2 TERF2IP TERF1-1 TINF2 DSCC1 RFC5 RFC3 CTC1 RFC4 CHTF18 RFC1 STN1 ACD RFC2 TEN1 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 TERF2 POLD1 POT1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 CCND1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDK4 GSK3B DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function TTR STRA6 RBP4 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia IVD RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription HSPA8 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA12 CA3 CA1 CA7 CA14 CA2 CA6 CA13 CA4 CA5B CA5A CA9 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion INMT BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1-1 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME RAC1 GGT7 GGT6 VAV1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 GLYATL3 ACSM5 ACY1;ABHD14A-ACY1 GLYAT ACSM4 ADH1C;ADH1B;ADH1A SLC22A2 SLC22A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 PCK1 PON3 BCHE GGT1 PON1 ADK ADAL ABCG2 GSTT1 PNP-1 NT5C2 CNDP2 ADA VAV3 ABCC4 TPMT GGT5 ABCC5 HSD11B1 ALB NME2 ACSM2A;ACSM2B HSD11B2 SERPINA6 GMPS GSTM1;GSTM2-1 ITPA CES1 GSTA3;GSTA1 NME1 VAV2 IMPDH1 GUK1 IMPDH2 HPRT1 GSTA3;GSTA5;GSTA1;GSTA2 NUDT15 SLC28A2 SLC29A1 XDH SLC28A3 SLC29A2 ABCC3 GSTP1 CES2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 BSG UGT2A1 UGT1A1;UGT1A6 ABCC2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A3 NAT1 ABCB1 ABCC1 SULT2A1-4 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO1A2 SLC22A8 SLC29A3 SLC16A1 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling LEF1 CCND1 CTNNB1 MYC RUNX3 TCF7L2 TCF7L1 TCF7 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer SMAD2;SMAD3 SMAD4 TGFBR1-1 TGFBR2 TGFB1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K NTRK3 PIK3R1 NTF3 IRS1 PIK3CA SRC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly LAMA3 ITGB4 COL17A1 LAMC2 DST PLEC CD151 ITGA6 LAMB3 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin ALDH2 MAOA SLC6A4 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle PRKAA2 SLC25A20 PPARD CPT1A MID1IP1 THRSP CPT2 CPT1B PRKAB2 PRKAG2 SLC22A5 RXRA NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis IMPDH1 IMPDH2 PFAS ATIC PPAT ADSL CAD UMPS GART PAICS DHODH ADSS1 GMPS ADSS2 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM2 MRM3 MTERF3 MTERF4 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 NCBP2-1 HNRNPM HNRNPF HNRNPA1-1 GAB1 FRS3 PLCG1 UBA52 ESRP1 TIAL1 TIA1 RBFOX2 ESRP2 PTBP1 RPS27A UBB;UBC CBL POLR2A POLR2B NRAS POLR2C POLR2D POLR2E POLR2F MAPK1 POLR2G HRAS POLR2H POLR2I MAPK3 POLR2L FGFBP1 BRAF FGFBP3 FRS2 GTF2F1 HNRNPH1 PPP2R1A GTF2F2 PIK3CA FGF1 POLR2J;POLR2J2;POLR2J3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 SOS1 FGF20 FGF23 FGF22 FGF16 FGF18 MKNK1 SPRY2 FGF10 PTPN11 PIK3R1 PPP2CB;PPP2CA NCBP1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors LPAR5 S1PR3 S1PR1 S1PR2 S1PR5 PLPPR1 S1PR4 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR PIGK PIGS PIGU PIGT PLAUR PGAP1 GPAA1 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL2 OS9 DHH ERLEC1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 HHAT PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 SYVN1 RPS27A UBB;UBC ADRM1 SEL1L PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 IHH PSMC4 PSMC1 SHH TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling TAB2 DUSP6 TAB1 DUSP7 LRRC14 USP14 NLRX1 RPS6KA1 FOS NLRC5 NOD1 NOD2 AGER IRAK2 S100A12 N4BP1 TNIP2 USP18;USP41 OPTN-1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE UBE2D1 MAP3K8 NFKB2 IRF7 TIFA ALPK1 MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ATF2 PTPN11 MAP2K7 MAP2K6 LY96 PPP2CB;PPP2CA PPP2R5D MEF2C MAPK9 MAPK8 TLR4 MAPK7 IKBKB IKBKG MAPK10 BTRC MAP3K7 SKP1 CHUK FBXW11 APP JUN ELK1 UBA52 CUL1 UBE2D3-1 RELA RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKBIB TBK1 IRF3 CASP8 RIPK3 RPS6KA5 TRAF2 BIRC2 BIRC3 HMGB1-1 RIPK1 RIPK2 FADD ATF1 SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP DUSP4 MEF2A DUSP3 UBE2D3;UBE2D2 UBE2N VRK3 TAB3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP5MJ ATP5MG ATP5ME DMAC2L ATP5PF ATP5PD ATP5PB ATP5F1C ATP5F1D ATP5PO ATP5MC2 SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 NTRK2 RAC1 CDK5 BDNF TIAM1 CDK5R1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation NTRK1 CRK KIDINS220 BRAF NGF YWHAB RAP1A MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis MOCOS MOCS2 MOCS3 GPHN INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing PABPN1-1 CPSF4 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD MAT1A CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 MAD2L1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 BUB1B CDC20 CCNA2-1 CCNA1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response ABCE1 FLNA PDE12 DDX58 OASL OAS1 OAS3 RNASEL VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways HDAC2 H2AC16;H2AC11 TLR8 TLR7 TLR3 PML C1S SH3KBP1 MBL2-1 MASP1 CTNNB1 CGAS IRF7 DHX9 YWHAB PRMT1 XRCC6 XRCC5 STING1 NPM1-2 SMAD4 SOS1 YBX1 HDAC3 CTSV;CTSL LY96 XPO1 EP300 MED1 CREBBP APOA1 JAK2 NCOR1 TBL1XR1 TLR4 NFE2L2 PPIA FKBP1A YWHAE RBX1 ATP6V1H ZBP1 TBK1 IRF3 FIP1L1 HDLBP CUL3 AP2A1 AP2A2 LIG4 XRCC4 AP2M1 RB1 AP2S1 DAXX ARID4A AP2B1 ARID4B FNTA BLNK HMG20B JAK3 P4HB IL1R1 IFNGR1 IFNGR2 SIGMAR1 NUP107 TYK2 SAP30 BRMS1 IFNAR1 PHF21A CD79B PPP1CC CD79A SAP30L S1PR1 SAP18 SUDS3 CRBN STAT2 DYNC1LI1 RCOR1 FNTB;CHURC1-FNTB CPSF2-1 DYNC1LI2 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T HSPG2 WDR33 NUDT21 CLP1 PCF11 NUP160 PAPOLA SDC4 SYMPK SDC2 SDC3 NUP85 RPS27 SDC1 SEC13 NUP133 RANGAP1 DYNC1I2 NUP43 DYNC1I1 RANBP2 DYNC1H1 GPC1 TAOK1 GPC3 GPC2 GPC5 GPC4 GPC6 NUP37 AGRN TJP1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT TKFC POLR2A POLR2B POLR2C POLR2D POLR2E CTR9 POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L RNGTT LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 PAF1 H2AC14 AKT2 AKT3 AKT1 PROS1 CLDN1 CSNK2A2 CD33-1 CSNK2B MRC1 EMC4 HSPA5 TIMD4 RPN2 MERTK MAPKAP1 AXL TYRO3 RPN1 MAPRE3 GAS6 LY6E PIK3R1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN H2AC20 CD28 EZH2 MAGT1 RAC1 JAK1 VAV1 CSNK2A1;CSNK2A3 RICTOR TRAF3 CD14 PAK2 IKBKE BRD4 SUZ12 H2BC5 STAT1 H2BC1 VCP-1 HNRNPU TUSC3 MTA1 ANO8 MTA3 NEK2 ANO9 ANO6 H2AC4 ANO4 ANO5 TMEM258 ANO2 ANO3 ANO1 OST4 OSTC STT3A ANO10 STT3B GSK3A PARP6 PRR5 PARP4 GSK3B GALNT1 PARP16 PARP9 PARP14 PARP8 H2BC21 PARP10 MLST8 PRKG2 YWHAG EED PDPK1 DDOST DAD1 LCK RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN RBBP7 PTPN11 MTOR CD4 H2BC15;H2BC3;H2BC11;H2BC12 TSG101 PTPN6 VPS4B PDCD1 VPS4A MVB12B CCNK MVB12A CCNT1 VPS36 VTA1 ELL VPS37C GTF2B VPS37D ELOC-1 VPS37A TAF7L SNF8 ELOA VPS37B ELOB NELFB UBAP1 NMT2 NELFA VPS25 NELFCD VPS28 NELFE CHMP5 SUPT16H TBP NCBP1 GTF2A1 GTF2A2 CTDP1 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GJA1 RCC1 NMT1 TUFM CCR5 RANBP1 TUBB4A;TUBB;TUBB8B;TUBB8 CSNK1A1 DDX58 NUP205 IFIH1 NUP188 RNF135 PSIP1 SIKE1 AAAS CLEC4M;CD209-2 MAVS TRIM25 NUP42 NUP62 SRPK2 TPR SRPK1 BANF1 CX3CR1 ITGB1 NUP88 RAB5B RAE1 RAB5C KPNA1 IGF1R NDC1 NCL-1 NUP214 RAB5A NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 RPL4 RPL30 DOCK2 RPL3 CALR-1 RPL32 HSPA1A;HSPA1B RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 KPNA7 RPL35 RPL38 KPNA5 KPNA2 RPS11 KPNA3 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 PPP1CB RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 PPP1CA RPL26 RPL29 RPL28 KPNB1 RPL10;RPL10L-1 KPNA4-1 CPSF4 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 CLTC CLTA RPS4X RPL7A GBP2;GBP3;GBP1 RPLP2 RPL36-1 HSP90AA1 PARP1 RPS3A DNAJC3-1 CANX RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 NRP1 RPL35A RPL23A PABPN1-1 RPL22L1 NCK1 FAU RAN RPL26L1 CXCR4 RUNX1 FASN DPM1 DPM2 U2AF1L5;U2AF1 DPM3 EIF4A3 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 TMPRSS2 ACE2 DHX38 SRSF11 ELK1 SRSF4-1 ALYREF RNPS1 ARF1 HSPA8 F2 COMT PIK3R4 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 B2M TLR9 PIK3C3 AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL6R KEAP1 UBE2L6 HERC5 TRAF6 UBE2V1 UBE2N TAB3 TAB2 TAB1 YWHAH ATG7 YWHAZ HDAC1 CAV1 ELAVL1 C4BPA C4BPB CLU IMPDH1 IMPDH2 HSP90AB1 ROCK1 ROCK2 CUL5 UBA7 UBA6 UBA5 UBR4 CPSF7 HNRNPC VIM RBMX UBA3 UBA1 FURIN H2BC18 RPTOR BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG ISCU EIF4E EIF4G1 VHL ACOT2;ACOT1 SEC23A SAR1B SCAP GRPEL1 SEC24B HYOU1 SEC24A MED19 MED18 PQBP1 MED11 SEC24D-1 MED29 MED22 MED21 SP1 ATL2 SRRT VPS33A VPS33B SEC24C PATJ ZCRB1 MPP5 CRB3 SNRNP200 G3BP1 G3BP2 FUS NACA BCAS2 CTNNBL1 PRCC HNRNPA0 HNRNPA3 GPKOW CASP1 CDC5L KDELR1 CCAR1 CD2BP2 PCBP1 PCBP2 PDCD6IP RIPK3 RBM10 MED13L BST2 RETREG1 SUGP1 DHX15 UFD1 CHMP4C DHX16 ARIH1 CHMP4B SFTPD CHMP3 BCAP31 CHMP4A PEX19 NLRP12 CHMP6 HNRNPA2B1 CHMP7 IL17F IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG RIPK1 PPIB RTN3 DDX46 DDX42 SUN2 RBM17 ITCH DYNLT1 BUD31 CHMP2B MMP9 CHMP2A RBM22 DDX23 RRBP1 SMNDC1 CNBP-1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM NPLOC4 HNRNPK HNRNPF HCK CD8B;CD8B2 HNRNPD CLINT1 ELMO1 HNRNPA1-1 SF3B4 SF3B5 MED28-1 SF3B2 SF3B3 ISY1;ISY1-RAB43 SF3B6 SF3B1 SF3A3 DDX3X-1 SF3A1 SF3A2 XAB2 PHF5A AUP1 IPO7 CLEC5A TXNL4A SNRPN BAG2 PYCARD CHERP CYSLTR1 P4HA1 P4HA2 P4HA3 RCAN3 EIF4G3 EIF4G2 EIF4E3 PTBP1 BTK PLRG1 LARP1-1 ATP1B2 SNRPA1 ATP1B1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A PLCG2 SEC11C CAMK2B SNRNP40 CAMK2D VPS41 CAMK2A DNAJA2 NLRP3 ATP1A4 VPS45 PPIL3 PPIL4 ATP1A3 PPIL6 ATP1A2 SRRM2 AQR CRNKL1 ATP1A1 NMI PRPF19 CAMK2G CHMP1A TOMM70 ATP1B3-1 IL17RC IL17RA SYK TLR1 FXYD2;FXYD6-FXYD2 HNRNPH1 HNRNPH2 TLR6 TLR2 FXYD4 SPCS3 FXYD3 SPCS2 SPCS1 FXYD1 CWC25 FXYD6 PPIL1-1 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 LIG1 IFNB1-4 BCL2L1 EEF1A1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SMN2;SMN1 GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX20 SNRPE-2 SNRPG-2 LOC110384692;C4A;C4B_2;C4B RIPK2 NOD1 NOD2 IRAK2 ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS GOLGA7-1 MGAT4C ZDHHC9 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 CCNC-1 SFN MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 MED23 MED25 MED24 MED20 EGFR MBD3 GATAD2B GATAD2A EXOC1 GBF1 MED30 ITGA4 COG1 TRIM28 SNW1 XRN1 KDM1A FKBP4 MED31-1 DDX5 PTGES3-1 IRAK1 SMAD2;SMAD3 CHD4 CHD3 YWHAQ MTA2 REST MED8 MED4 MED6 MED7 NEDD4L PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A NCOR2 UBB;UBC ADRM1 NFKB1 TAL1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 GPS2 PSMC1 NFKBIB UBE2I NR3C1 SUMO1 NRBP1 FEN1 EIF4A2 EIF4A1 CDK8 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases ATP11C ATP11B ATP11A CALM3;CALM1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B ATP4A CUTC ATP7B ATP7A ATP2A3 ATP2A2 ATP2A1 ATP1B2 ATP10D ATP1B1 ATP10B ATP10A ATP2C2 ATP2C1 CAMK2B CAMK2D CAMK2A ATP1A4 ATP9B ATP9A ATP1A3 ATP13A1 ATP1A2 SRI ATP1A1 CAMK2G ATP13A4 ATP13A5 ATP1B3-1 ATP13A2 ATP2B4 ATP2B3 FXYD2;FXYD6-FXYD2 ATP2B2 ATP2B1 FXYD4 FXYD3 FXYD1 FXYD6 PDZD11 ATP8A2 ATP8A1 ATP12A PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends TERF2IP H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 ACD H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ TERF1-1 H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 TERF2 H2BC1 POT1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins CLSPN ROCK1 BMX SATB1 CASP8 PRKCD SPTAN1 LMNB1 APC CASP6 BCAP31 BIRC2 VIM CASP7 CDH1 DSP DBNL TJP1 CASP3 GAS2 CTNNB1 OCLN-1 MAPT ADD1 DSG1 PKP1 PLEC GSN STK24 DSG2 STK26 DSG3 TJP2 PRKCQ FNTA ACIN1 PTK2 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism MCCC2 MCCC1 PPM1K RPIA AUH GALNS IVD HIBCH GALE PC CHSY1-1 TBXAS1 MGAT2 ST3GAL3 MOGS POMC MAN1B1 APRT PNP-1 ADA PCCA MMAA PCCB MMUT TPMT MMAB MMACHC MMADHC HPRT1 DPAGT1 ALG8 ALG9 ALG6 ALG2 MAOA ALG3 ALG12 ALG1 MPDU1 RFT1 SLC25A15 CPS1 ARG1 ASL CYP24A1 NAGS CYP21A2 NMRAL1 ASS1 CYP11B1;CYP11B2 OTC BTD THBS1 CYP17A1 HLCS SFTPB CBLIF CD320 CYP19A1 HGSNAT ACY1;ABHD14A-ACY1 SLC34A2 CYP2R1 NOTCH1 ACACA ALG11 CYP27A1 ECHS1 CYP7B1 GSS TCN2 G6PC1 BCKDK BCKDHA BCKDHB SFTPD DBT DLD ABCD4 LMBRD1 MC2R IDUA HEXB CUBN NCAN HEXA AMN BGN DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GGT1 GUSB ARSB CYP2U1 CYP1B1 MPI PMM2 IDH1 ABCA3 DAG1 FMO3 GALNT12 SEMA5A POMT2 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 GALM-2 ADAMTSL1 LFNG OMD ADAMTS4 TALDO1 ADAMTS5 C1GALT1C1 HSPG2 ADAMTS2 ADAMTS3 PPP1R3C ADAMTSL5 CYP26B1 NHLRC1 ADAMTSL4 ADAMTS1 SDC4 ADAMTSL2 SDC2 MUC12 ALG14 MUC13 SDC3 MUC15 THSD7A GNS ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 CHST14 SBSPON MUC3A POMGNT1 MUC5AC EXT1 ADAMTS20 B3GLCT EXT2 CFP B4GAT1 SDC1 THBS2 ADAMTS12 THSD1 GBE1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 KHK GYS2 MUC2 ADAMTS13 PAH GYS1 ADAMTS19 ADAMTS18 DHDDS ADAMTS17 DPM1 DPM2 MUC7 CHST6 DPM3 CSF2RB MUC4 CSF2RA MUC6 GNE GALNT3 SFTPC MUC17 GAA C1GALT1 MUC5B MUC20 MUC21 NEU1 ALDOB CTSA NUS1 CHST3 PAPSS2 SRD5A3 GFPT1 GPC1 DOLK GPC3 UBA52 GPC2 GPC5 GPC4 GPC6 AGRN FMOD NAGLU GYG2 GYG1 EPM2A RPS27A KERA UBB;UBC SLC26A2 OPLAH MTRR AHCY MTR-1 MAT1A B3GALT6 GCLC G6PC3 OGN GCLM GALK1 B4GALT1 FDX1 FDXR SGSH SI LCT SLC37A4 ACAT1 PGM1 UGT1A1;UGT1A6 SLC35D1 DCXR CYP27B1 NOTCH2 NOTCH3 NOTCH4 CYP4F22 CYP11A1 B4GALT7 GALT PRELP ACAN B3GAT3 LUM INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling PTPN11 SOCS3 JAK2 TYK2 IL11 JAK1 CNTFR OSMR CNTF LIFR IL31 IL31RA OSM IL6R CBL CTF1 LIF IL11RA CLCF1 IL6 IL6ST CRLF1 STAT1 STAT3 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 FLT3 FLT3LG PTPRJ ABL2 RPS27A UBB;UBC CBL SH2B3 SLA2 SLA SOCS2 CSK UBA52 SOCS6 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas LAMA5 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 LAMA4 FGF2 LAMA3 FN1 FGF4 LAMB1 LAMC2 FGF7 LAMC1 VTN EGF FGF10 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PTGS2-2 PTGDS PTGES3-1 PRXL2B PTGR2 PTGS1 HPGD PTGES2 PTGES HPGDS PTGIS TBXAS1 CYP8B1 CBR1-1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1 MUC5B MUC20 MUC21 MUC3A MUC5AC MUC1 C1GALT1C1 MUC2 MUC7 MUC4 MUC12 MUC6 MUC13 MUC17 MUC15 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H POLR2I POLR2L GTF2H1 TAF8 GTF2F1 TAF4B GTF2H3 TAF7 GTF2F2 TAF6 GTF2H4 TAF5 CDK7 TAF4 POLR2J;POLR2J2;POLR2J3 TAF3 ERCC3 TAF2 ERCC2 TAF1 MNAT1 GTF2B TAF7L TBP GTF2A1 GTF2A2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH TAF9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C TAF15 POLR2D TAF12 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria GSDMD DIABLO-1 BAX CYCS-1 GSDME BAK1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria BCL2L11 MAPK8 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism ELOVL1 ELOVL2 FADS2 ELOVL3 FADS1 ABCD1 ELOVL5 ACSL1 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM MMAA MMUT REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion SLC2A2 GNB1 GNB4 SYT5 GNB3 GNB5 KCNC2 SNAP25 CACNA2D2 STX1A VAMP2 KCNB1 CD36 KCNS3 AHCYL1 PRKACA-1 PRKAR1B PRKACB-1 STXBP1 CACNB2 CACNB3 GLP1R FFAR1 PRKAR2B CACNA1A CACNA1E GNA14 INS;INS-IGF2 ITPR1 GNA15 GNGT1 ITPR2 GNA11 ITPR3 RAP1A KCNJ11 ABCC8 ADRA2C PRKCA ADRA2A GNAS-1 PLCB3 PLCB1 PLCB2 PRKAR2A GNAQ CACNA1C ADCY8 SLC2A1 GNAI1 PRKAR1A ADCY6 GNAI2 RAPGEF3 ADCY5 RAPGEF4 GNG10 GNG2 GNG5 GNG4 CACNA1D GNG8 AKAP5 KCNG2 CHRM3 ACSL4 ACSL3 GCG GNG13 IQGAP1 GNB2 MARCKS UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis COQ5 HPDL COQ3 COQ2 PDSS2 PDSS1 COQ8A STARD7 COQ9 COQ7 COQ6 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism CTRB1;CTRB2 MMAB MMACHC MMADHC ABCC1 ABCD4 TCN2 LMBRD1 LRP2 PRSS3;PRSS2;PRSS1 CBLIF LDLRAP1 CUBN MMAA TCN1 AMN CD320 MTRR MMUT MTR-1 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG PLD4 PGS1 PTPMT1 PLD6 PLD1 PLD3 CDS2 PLD2 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events CAMKK2 CAMK2G PRKCA ADCY4 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 PDE1C ADCY7 KPNA2 PDE1B PDE1A ADCY6 PRKAR1A GRK2 ADCY5 PRKCD PRKCG PRKACA-1 ADCY9 PRKACB-1 PRKAR1B NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A CAMKK1 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer MDM2-2 TSC2 MAPKAP1 MTOR MLST8 AKT1S1 PDPK1 CDKN1A CDKN1B FOXO1-1 CHUK BAD RPS6KB2 CASP9 AKT2 RICTOR AKT3 AKT1 NR4A1 GSK3A FOXO3 PRR5 GSK3B FOXO4 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly H2AJ MBD3 GATAD2B GATAD2A HDAC2 H2BC5 HDAC1 PCK1 H2BC1 MTA1 MTA3 H2AC4 UBE2I PWWP2B MBD3L1 H2BC21 PWWP2A MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 H2AZ2;H2AZ1 SUMO1 G6PC1 H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CHD4 CHD3 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FBP1 MTA2 NR2C2 ZNF592 CHD5 IKZF1 H2AC20 IKZF2 IKZF3 PHF6 H2AB2;H2AB3;H2AB1 ZMYND8-1 ZNF827 ZNF687 TCF19 MBD2 NR2F2 CDK2AP2 CDK2AP1 ZNF532 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance RPS6KA1 SIAH2 SIAH1 SH3KBP1 SRC GRB10 MET SH3GL2 VAV3 SHC3 NRAS MAP2K2;MAP2K1 MAPK1 VAV2 HRAS MAPK3 FRS2 HSP90AB1 ROCK1 ROCK2 CLTCL1 SOS1 ACTG1 SHC1-1 PIP5K1C CFL1 ERBB2 ITGB3 PPP3CB GRB7 TLN1 RND1 PLXNA1 EIF4G1 ARHGEF11 CDK5 ARHGEF12 RHOB CDK5R1 ARHGEF28 RBX1 RHOC DLG1 DLG3 ARHGEF7 DLG4 NGEF PLXNB1 GIT1 DPYSL4 SDCBP DPYSL5 DPYSL3 UNC5C UNC5D AGAP2 DSCAML1 PLXNC1 SEMA6A SEMA6D SEMA7A MMP9 RAP1GAP PLXNA2 COL4A2 COL4A1 PLXNA3 PTPRC COL6A2 PTPRA RELN DAB1 PLXNB3 COL4A4 TREM2 VLDLR COL6A1 SEMA3A COL4A3 NTN4 SEMA3E ABLIM1 COL9A1 PSENEN ABLIM2 PSEN2 ABLIM3 PSEN1 SEMA4A APH1A COL6A3 NCSTN ARTN COL4A5 APH1B COL9A3 GFRA3 RGMB COL6A6 GFRA2 COL6A5 COL9A2 GFRA4 RASA1 RGMA AP2A1 CD72 AP2A2 NRTN DSCAM DOK1 DOK2 TYROBP AP2M1 DOK4 DOK5 NCAN DOK6 SEMA4D CACNA1S PRNP LIMK2 PSPN LIMK1 RRAS HJV MYH14 CRMP1 MYH10 PDLIM7 PRKACA-1 PRKACB-1 AP2S1 PLXND1 AP2B1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1B ARPC1A WASL ACTR2 RPS6KA3 RPS6KA2 MYO10 SDC2 RPS27 PITPNA MAPK7 CLASP1 CLASP2 GAB1 GRIN2B GPC1 TIAM1 PLCG1 RPS6KA6 AGRN ADAM10 CSNK2A2 CSNK2B GFRA1 NEO1 PIK3R3 GDNF PIK3R2 PIK3R1 LYN YES1 RAC1 EPHA1 FARP2 ARHGAP39 CSNK2A1;CSNK2A3 SRGAP3 SLIT2 SRGAP2 SRGAP1 ROBO1 PAK1 PAK3 PAK2 GRIN1 MYH9 GSK3B PIK3CD PIK3CB PRKCA PIK3CA CDC42 FYN PTPN11 ELOC-1 EPHB6 EPHB1 ELOB EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 NCBP1 MMP2 EPHA3 EPHA10 EFNA5 EFNA4 EFNB2 EFNB1 EFNB3 EFNA1 EFNA3 EFNA2 NCBP2-1 EGFR UNC5A UNC5B ACTB-1 CACNA1C RHOA RPS6KA5 ITGB1 TRIO ITSN1 ARHGAP35 ITGA5 RPL4 RPL30 RPL3 DOCK1 RPL32 EPHA2 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 KALRN RPS15 RPS14 RPS17 RPS16 PAK4 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 FES RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 CACNA1H MYL12A RPL3L CACNA1G MYL12B RPS25 RPL5-1 RPS29 CACNA1I RPL27A RPS20 RPS21 MYH11 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 ITGAV CLTC CLTA PTK2 RPS4X RPL7A BUB1B-PAK6;PAK6 RPLP2 MSI1 RPL36-1 DAG1 HOXA2 MYL6 HSP90AA1 ISL1 PFN1 RPS3A CUL2 GSPT2 SEMA5A RPL13A-1 GSPT1 FLRT3 RPL11 PRKAR2A RPS27L RPS15A ABL2 RPL14 VASP RPS3 PABPC1;PABPC3 RPL13 CXCL12 NRP2 RPL12-1 LHX3 CNTNAP1 RPS2 LHX2 RPS6KA4 ALCAM RPL18 LHX4 SCN11A RPL17 LHX9 CHL1 RPL19 ROBO2 DPYSL2 RPL35A NRP1 RPL23A SCN9A USP33 NCK2 NRCAM RPL22L1 NCK1 SCN5A UPF2 EPHB2 FAU SPTAN1 CAP1 SCN1B DCC RPL26L1 SCN1A ENAH ETF1 KIF4B;KIF4A LYPLA2 EVL LDB1 PFN2-1 ANK2 SOS2 ANK3 ANK1 CXCR4 CACNA1D SPTB AKAP5 NTN1 DNM1 ZSWIM8 DNM3 SHTN1 SLIT1 GAP43 SLIT3 SCN10A PAK5 CAP2 SCN8A KCNQ2 MYO9B NUMB NELL2 DCX KCNQ3 SCN4A EZR SCN4B ITGA9 SPTBN4 SPTBN5 SPTA1 SCN7A NCAM1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX EIF4A3 MSN CASC3 RANBP9 L1CAM NFASC ITGA10 CNTN1 CNTN2 CD24 SCN2A SCN2B PSMD8 ST8SIA4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ST8SIA2 RBM8A PSMC2-1 PSMA5 PSMA6 RET PSMA3 PSMA4 PSMA1 UBA52 MAGOH;MAGOHB PSMD12 PSMD11 PSMD14 UPF3B PSMD13 RNPS1 PSMA7 PSMB6 PSMB7 PSMB4 CLTB PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC CACNB1 ADRM1 CACNB2 CACNB3 PSMA2-1 CACNB4 HSPA8 SEM1 PSMC5 PSMC6 DNM2 PSMC3 PSMC4 PSMC1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 ITGA2B IRS2 SHANK3 LAMA1 LAMB1 LAMC1 GAB2 ITGA2 ITGA1 ABL1 PLXNA4 PRKCQ PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 PLCB3 PLCB1 GRIK3 PLCB2 GNG13 GNGT1 GNG10 GNB2 GNG2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSI SUMF2 SUMF1 ARSG STS ARSL ARSB ARSA ARSD-1 ARSJ ARSK ARSH DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A TPST2 TPST1 VWF F9 F10 F2 F8 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 SEM1 RHNO1 BLM RAD51AP1 WRN BRIP1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism KYNU KYAT3 SLC7A5 HAAO AADAT SLC3A2 KMO TDO2 KYAT1 IDO2 IDO1 SLC36A4 ACMSD AFMID REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation FOXO1-1 SIRT1 TXN EP300 FOXO3 SIRT3 CREBBP TXNIP KAT2B FOXO4 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling TGFBR3 GIPC1 FGF2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer SMAD2;SMAD3 FKBP1A TGFBR1-1 TGFBR2 TGFB1 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC34A2 SLC20A2 SLC34A1 SLC20A1 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen GP1BB GP5 VWF GP1BA GP9 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS VCAN CSPG5 CSPG4 CHSY1-1 NCAN BGN DCN BCAN DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER POLD2 CHD1L ERCC5;BIVM-ERCC5 PARP1 RPA1 RPA2 GTF2H1 XPA GTF2H3 POLE4 GTF2H4 RPA3 POLE2 ERCC3 POLE3 ERCC2 ERCC4 ERCC1 UBA52 POLK DDB1 CUL4A POLE CUL4B RFC5 RFC3 RFC4 RFC1 RFC2 RPS27A UBB;UBC RBX1 PCNA GTF2H2C;GTF2H2C_2;GTF2H2 POLD3 POLD4 DDB2 PARP2 POLD1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling ATP6V1C1 ATP6V1C2 CTSD ATP6V0A1 ATP6V1F ATP6V0E2;ATP6V0E1 IDE TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 ATP6AP1 INSR ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A PTPRF INS;INS-IGF2 PTPN1 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V1G3 ATP6V1D RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPL34 RPL10A CEBPB RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X ATF4 RPL7A RPLP2 RPL36-1 GCN1 RPS3A EIF2AK4 DDIT3 RPL13A-1 IMPACT RPL11 CEBPG RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 ASNS RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 TRIB3 ATF3 ATF2 EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPS27 RPL4 RPL30 RPL3 RPL32 RPL31 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling TAB2 TAB1 LRRC14 USP14 NLRX1 PELI3 PELI2 NLRC5 NOD1 MAP3K3 NOD2 AGER IRAK2 S100A12 N4BP1 TNIP2 USP18;USP41 MAP3K8 IL1RN IL1R2 NFKB2 TIFA ALPK1 IL1R1 MAP2K2;MAP2K1 IRAK1 MAP2K4 MAP2K6 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMC2-1 APP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 SQSTM1 RELA IRAK3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 RBX1 PSMA2-1 TP53 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NFKBIB CASP8 TRAF2 IL1A IL1B PELI1 HMGB1-1 RIPK2 TOLLIP MYD88 SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 UBE2V1 IKBIP UBE2N IRAK4 TAB3 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 PTPN11 HGF GAB1 MET TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death CASP8 FADD TLR3 TICAM1 RIPK3 RIPK1 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se CBS;CBSL MAT1A HNMT AHCY GNMT NNMT CTH SCLY DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation PRKCG PRKCB PRKCA STX4 STXBP3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction PPEF1 GNB1 GUCY2D HSD17B6 HSD17B1 STRA6 PLB1 CALM3;CALM1 RLBP1 SDR9C7 GPC1 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GPC3 APOA2 GPC2 APOA4 GPC5 APOE GPC4 CAMKMT GPC6 RGS9BP NMT1 AGRN TTR LRP1 LPL LRP8 GRK1 GRK7 ABCA4 AWAT2 LDLR GPIHBP1 BCO2 LRAT BCO1 APOC3 RCVRN FNTA LRP10 APOC2 GNGT1 LRP12 RBP4 RBP2 METAP1 RBP3 METAP2 RBP1 RETSAT AKR1B15;AKR1B10 PRKCA CYP4V2 RDH12 PDE6B PDE6A FNTB;CHURC1-FNTB OPN1SW CLPS DHRS3 HSPG2 PNLIP DHRS9 APOM RDH11 SDC4 SDC2 RDH10 RDH5 SDC3 LOC118142757;GUCA1A RPE65 MYO7A RDH8 SDC1 LRP2 SLC24A1 SAG CNGA1 NMT2 RHO GUCA1C GNAT1 CNGB1 APOB PRKCQ APOA1 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AGMAT AZIN2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HBEGF HRAS SOS1 TGFA EGFR EGF AREG EREG BTC NRAS EPGN BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein NPL NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 CTSA SLC35A1 ST6GALNAC2 NUS1 ST8SIA1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK SLC17A5 FCSK DOLPP1 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 GLB1 ST6GALNAC3 MVD ST6GALNAC4 ALG11 GMPPB PMM1 MPI GMPPA PMM2 DPAGT1 ALG8 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 ALG10;ALG10B RFT1 HK1 ALG14 ST3GAL6 ST6GALNAC1 CMAS NANP FPGT PGM3 ST6GALNAC6 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 ASCC2 RPS11 ASCC3 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 UBE2D1 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 UBE2D3-1 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A UBB;UBC RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ZNF598 RPS27 RPL4 RPL30 RPL3 RPL32 UBE2D3;UBE2D2 RPL31 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha MED9 CDK19 FADS1 G0S2 SIN3A FHL2 TNFRSF21 MED28-1 CPT1A ANKRD1 APOA2 GRHL1 APOA5 ANGPTL4 TXNRD1 CPT2 FABP1 ABCA1 RXRB NR1H3 MED31-1 ARNT2 NCOA3 NRF1 THRAP3 FAM120B CCNC-1 RGL1 PPARGC1B SMARCD3 HDAC3 CHD9 MED16 MED15 SULT2A1-4 MED17 NPAS2 MED12 MED14 ARNTL HELZ2 MED13 MED10 TGS1 EP300 PPARGC1A NCOA1 MED27 MED1 MED26 NCOA2 CREBBP ACADM MED23 MED8 NCOA6 MED25 MED4 APOA1 MED6 NR1D1 MED24 MED7 MED20 NCOR1 TBL1XR1 CARM1 CLOCK AHR PLIN2 CYP1A1 AHRR HMGCS1-1 CD36 SREBF2 MTF1 NCOR2 ACSL1 PEX11A FDFT1 GPS2 MED19 NFYB MED18 NFYC MED11 MED29 MED22 SP1 MED21 MED30 NFYA-1 NR1H2 RORA TIAM2 NR1H4 AGT CYP7A1 ME1 RXRA PPARG ALAS1 PPARA MED13L HMGCS2 TRIB3 ABCB4 GLIPR1 ARNT ESRRA SLC27A1 CDK8 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 FBXL7 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 FBXL18 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 AURKA PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex SMARCA2 SMARCE1 SMARCD3 SMARCA4 PHF10 SMARCB1 ARID2 ACTB-1 SMARCC1 PBRM1 SMARCC2 BCL7A BCL7C BCL7B SMARCD1 SMARCD2 ACTL6A BRD7 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia F9 F10 F8 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PTTG1;PTTG2 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 PLK1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CCNB1 CDC23 PSMD13 MAD2L1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 NEK2 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 BUB1B CDC20 CCNA2-1 CCNA1 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC CD320 TCN2 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense GBP2;GBP3;GBP1 CALM3;CALM1 CASP5;CASP4 GBP6 GBP7;GBP4 UBA52 UBE2D3;UBE2D2 RPS27A UBB;UBC DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response BARD1 MAPK8 BRCC3 TP53BP1 BABAM1 RAD50 BABAM2 UIMC1 ABRAXAS1 RNF8 RNF168-1 NSD2 ATM KPNA2 SMARCA5 PPP5C BAP1 UBXN1 UBA52 H2BC5 BAZ1B APBB1 KDM4A H2BC1 EYA1 EYA2 EYA3 EYA4 RPS27A UBB;UBC TP53 MDC1 PIAS4 UBE2I H2BC21 KDM4B UBE2V2 SUMO1 MRE11 BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 NBN CHEK2 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ABL1 HERC2 UBE2N MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis TERF2IP UBE2I H2BC21 SMC3 H2AZ2;H2AZ1 SYCP1 SYNE2 SYNE1 H2AJ SUN1 HSPA2 TEX12 SMC1B TERF1-1 SYCP3-2 SYCE2 SYCE1 REC8 FKBP6 H2AC14 STAG3 SYCP2-1 ATR BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 LMNB1 H2BC1 RAD21 H2BC15;H2BC3;H2BC11;H2BC12 STAG1 STAG2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 SUN2 H2AC20 H2AB2;H2AB3;H2AB1 SMC1A TERF2 POT1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization NECTIN4 NECTIN3 NECTIN2 NECTIN1 CADM3 CADM1 PVR CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis WDR5 ISL1 NKX2-5 GATA4 LEF1 SMAD1 SMAD4 EOMES GATA6 TBXT KAT5 LDB1 MESP1 TBX20 SMYD1 TBX1 MYOCD HAND1 HEY1 HAND2 KAT2A SRF HEY2 CTNNB1 MEF2C TBX5 FOXO4 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 HDAC1 CCNB1 CDK1 RB1 CDKN1A CDKN1B CCND1 FBXO5 E2F1 SKP2 TFDP1 TFDP2 CCNE2 CDK4 CCNE1 CDK2 PPP2R1B PPP2R1A RBBP4 RBL2 RBL1 PPP2CB;PPP2CA CDC45 MCM7 MCM3 MCM4 MCM5 MCM6 MCM2 CCNA2-1 CCNA1 E2F4-1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 CDC7 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 TK1 DHFR2;DHFR RRM2-1 PSMC5 TYMS PSMC6 PPP2R3B PSMC3 PSMC4 PSMC1 CCNH MAX CDC6 CDK7 MNAT1 AKT2 MYC AKT3 AKT1 POLE GMNN PTK6 LIN54 CKS1B LIN52 CDT1 LIN37 LIN9 MCM10 CABLES1 WEE1 ORC5 ORC4 DBF4 ORC6 ORC1 MCM8 ORC3 ORC2 E2F5 E2F6 PCNA PRIM2 PRIM1 POLA1 POLA2 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1-1 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance CUBN AMN HDLBP APOA1 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes CNOT2 CNOT3 E2F4-1 CARM1 CNOT8 CNOT9 PLAGL1 PLK3 CENPJ CDC25C BTG2 CCNB1 CDK1 TNKS1BP1 CDKN1A CDKN1B TP53 E2F1 GADD45A PLK2 TFDP1 TFDP2 PRMT1 CCNE2 CCNE1 CDK2 NPM1-2 RGCC SFN CNOT10 CNOT11 ZNF385A PCBP4 RBL2 RBL1 AURKA EP300 CNOT6L ARID3A PCNA E2F7 E2F8 BAX CCNA2-1 CNOT4 CNOT6 CNOT7 CCNA1 CNOT1 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling TNFAIP3 SHARPIN USP21 USP4 CYLD OTUD1 RBCK1 TBK1 TRADD CASP8 OPTN-1 IKBKE TRAF2 USP2 MIB2 BIRC2 BIRC3 XIAP TNF RIPK1 FADD TNFRSF1A RNF31 OTUD7B SPATA2 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions CSRP1 SNCB MTF1 MT2A MT3 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway LTBR LTA BIRC2 LTB BIRC3 TNFSF11 TNFRSF11A TNFRSF13C TRAF3 TNFRSF12A TRAF2 MAP3K14 TNFSF13B CD40LG TNFSF14 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin FSTL3 INHBB FST INHBA GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion GNB1 GNB4 GNB3 GNB5 GNAS-1 KCNC2 PRKAR2A ADCY8 ADCY6 PRKAR1A ADCY5 RAPGEF3 RAPGEF4 GNG10 KCNB1 GNG2 GNG5 GNG4 GNG8 AKAP5 KCNS3 PRKACA-1 KCNG2 PRKACB-1 PRKAR1B GLP1R PRKAR2B ITPR1 GCG ITPR2 GNGT1 GNG13 IQGAP1 GNB2 ITPR3 RAP1A PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination UCHL3 UBE2R2 RRAGA OTULIN UBE2J2 USP9X DERL1 USP5 UBE2C UBE2E1 UBA52 H2BC5 UBE2D1 UBE2B H2BC1 UBE2S VCP-1 RAD18 UBE2D3-1 BCL10 UBE2G1 UBE2G2 RPS27A UBB;UBC PRKDC UBE2Z CTR9 UBE2E3 WDR61 RTF1 CDC73 TMEM129 HLTF LEO1 RNF152 SHPRH PEX10 PEX2 PEX12 PEX13 UBE2V2 PEX14 RNF40 RNF144A SELENOS UBA6 WAC-1 RNF181 PAF1 USP7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF20 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2H H2BC15;H2BC3;H2BC11;H2BC12 UBE2W UBE2T UBA1 UBE2K CDC34 PCNA UBE2Q2 UBE2D3;UBE2D2 UBE2N SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea SNAP25 CACNA2D2 STX1A VAMP2 CASK SYN1 EPB41L1 RAB3A CACNB2 MYH9 DNAJC5 ATP2B1 TWF1 SPTAN1 RIPOR2 PCLO CLIC5 CAPZB MYO1C CIB2 BSN PJVK SYP EPS8 CABP2 TPRN CACNA1D PLS1 CABP1 TMC1 LRRC52 ESPN-1 OTOF MYO7A SLC17A8 TMC2 CAPZA1 MYO3B CAPZA2 MYO3A KCNMB1 KCNMA1 KCNQ4 FSCN2 PCDH15 USH1C ESPNL EZR CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN LHFPL5 SPTBN1 TMIE USH1G RDX STRC MSN MYO15A ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation LTBP1 MFAP5 ITGB8 FBN1 MFAP4 ITGB6 TGFB3 MFAP3 ITGA8 MFAP2 VTN LOX LOXL3 LOXL4 LOXL1 LOXL2 BMP2 ITGB1 GDF5 BMP10 BMP4 ITGB5 BMP7 TGFB2 EFEMP2 TGFB1 EFEMP1 ITGA5 FURIN FBN2 FBN3 ITGB3 FBLN1 FBLN2 FBLN5 LTBP4 ITGAV LTBP2 LTBP3 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling IL25 DUSP6 TAB2 DUSP7 TAB1 MAPK9 MAPK8 IL17RE MAPK7 RPS6KA1 IKBKB IL17RB FOS NOD1 NOD2 IRAK2 IKBKG MAPK10 BTRC IL17C MAP3K7 SKP1 TNIP2 CHUK FBXW11 JUN ELK1 UBA52 CUL1 MAP3K8 RPS27A UBB;UBC NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 IL17RC IL17RA PPP2R1B MAPK14 PPP2R1A MAPK11 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 RPS6KA5 MAP2K3 MAP2K4 ATF2 MAP2K7 MAP2K6 IL17F IL17A PPP2CB;PPP2CA RIPK2 ATF1 PPP2R5D TRAF6 UBE2V1 DUSP4 MEF2C MEF2A DUSP3 UBE2N VRK3 TAB3 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine TERF2IP H2BC21 H2AZ2;H2AZ1 H2AJ TERF1-1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 TINF2 OGG1 NTHL1 TDG MBD4 H2BC1 SMUG1 NEIL3 NEIL2 NEIL1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 H2AC20 H2AB2;H2AB3;H2AB1 TERF2 POT1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence TERF2IP HIRA H2BC21 UBN1 H2AZ2;H2AZ1 RAD50 H2AJ TERF1-1 ATM H2AC14 MRE11 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT5 H2BC5 TINF2 LMNB1 NBN H2BC1 ASF1A EP400 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC4 RB1 CDKN1A HMGA2 CDKN1B H1-0 H1-3 H1-2 H1-5 H2AC20 TP53 H1-4 H2AB2;H2AB3;H2AB1 CABIN1 CCNA2-1 CCNE2 TERF2 CCNA1 CCNE1 CDK2 POT1 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking WNT5A WNT9B WNT9A WNT16 PORCN WLS WNT5B VPS29 VPS35 TMED5 WNT8A VPS26A WNT8B SNX3 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 WNT10B WNT10A WNT3A WNT7B WNT2B WNT7A RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling PIK3CD PIK3CB MAPK7 PRKCA ARTN FRS2 GFRA3 GRB7 GFRA2 PIK3CA GFRA4 IRS2 SHANK3 NRTN GAB1 DOK1 SOS1 DOK2 SHC1-1 DOK4 RET GAB2 DOK5 PLCG1 DOK6 GFRA1 PSPN PTPN11 PDLIM7 PIK3R3 GDNF PIK3R2 PIK3R1 PRKACA-1 PRKACB-1 GRB10 RAP1GAP SHC3 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) ALOX5 LTC4S ALOX5AP PTGR1-1 HPGD ALOX12 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling RAC1 VAV1 IL33 PDGFRB TRAT1 NTRK3 PIK3AP1 IL1RL1 TGFA KIT FLT3LG CD86 CD80 SRC INSR MET INS;INS-IGF2 FLT3 PIK3CD PIK3CB MAPK1 PIK3CG PDGFB CD19 MAPK3 FRS2 PPP2R1B PPP2R1A PIK3CA IER3 LCK IRAK1 PIP5K1C STRN ESR2 FYN PTPN11 PPP2CB;PPP2CA PPP2R5E ERBB2 NRG2 PPP2R5B NRG3 PPP2R5A NRG4 PPP2R5D PIP4K2A PPP2R5C PIP4K2B PIP5K1A PIP5K1B EGFR NTRK2 BDNF GAB1 NTF4 NTF3 EGF EREG AREG BTC EPGN HBEGF NRG1 HGF ESR1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 AKT1 GAB2 FGF16 FGF19 FGF18 FGFR4 FGF10 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 MYD88 RHOG CD28 TRAF6 PDGFRA IRAK4 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes STEAP3 BCL2L14 BID ZNF420 PRELID1 NDRG1 CASP1 PMAIP1 ATM TP63 PRELID3A PPP1R13B NLRC4 IGFBP3 TP53I3 CHM CRADD PIDD1 CASP6 CASP2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP73 AIFM2 APAF1 BBC3 TMEM219 RABGGTB RABGGTA CASP10 BNIP3L TP53INP1 TP53 TP53BP2 PERP FAS BAX CREBBP BIRC5 BCL6 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 PTPN11 PIK3R1 FRS2 PIK3CA FGF1 FGF2 FGF3 FGF4 FGF6 GAB1 FGF9 FGF20 FGF23 FGF22 FGF10 DISEASE%REACTOME%R-HSA-1643685.19 Disease SIN3A HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC7 TXNRD1 PML HDAC10 HDAC11 IL10RA PRMT1 GP1BA PDGFB NPM1-2 SMAD4 ESR2 NR4A1 YBX1 CTSV;CTSL AXIN1 THBS1 ERBB2 HES1 ITGB3 ARAF PEBP1 ARRB1 PHB IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 MAP3K11 VCL SLC40A1 HEPH GOLGB1 SLC11A2 ALG11 ATP6V1H CP DCTN1 ZBP1 TBK1 IRF3 SLC9A6 SLC9A9 ABCA12 SLC4A4 BSG SLC39A4 SLCO2A1 BCKDK SLC27A4 BCKDHA ABCB6 BCKDHB DBT ABCB4 SLC5A2 DLD SLC33A1 SLC6A5 SLC26A4 SLC26A3 ABCD4 SLC6A2 SLC22A12 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC2A10 ABCC6 LMBRD1 SLC29A3 SLC24A4 SLC20A2 ABCB11 SLC35A2 SLC16A1 SLC24A5 HDLBP AP2A1 AP2A2 AP2M1 CUBN AMN PRKACB-1 AP2S1 ABCA1 AP2B1 P4HB IDH1 ENO1 PRF1 FOXM1 ICOS ZC3HC1 GALM-2 OMD TALDO1 HSPG2 CYP26B1 PPP1R3C NHLRC1 SDC4 SDC2 RDH5 SDC3 GNS CHST14 EXT1 EXT2 B4GAT1 SDC1 GBE1 KHK GYS2 GYS1 CHST6 CSF2RB CSF2RA GAA ALDOB CHST3 PAPSS2 PAPSS1 GPC1 SLC17A5 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN FMOD NAGLU GYG2 GYG1 EPM2A KERA SLC26A2 TKFC GCKR B3GALT6 G6PC3 OGN GALK1 B4GALT1 SLC2A1 SGSH HK1 SLC37A4 PGM1 DCXR CYP11A1 B4GALT7 GALT PRELP ACAN B3GAT3 LUM RPIA GALNS GALE PC CHSY1-1 TICAM1 TRAF3 CD14 IKBKE TBXAS1 FLT3LG HNRNPU MTA1 MTA3 ABCA4 APRT PNP-1 ADA ABCG8 ABCG5 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 PRKG2 DPAGT1 ALG8 ALG9 ALG6 ALG2 MAOA ALG3 ALK ALG12 EML4 ALG1 PPM1B HIP1 MPDU1 RFT1 BCL11A PRKAR1A EIF2AK3 STRN BIRC6 CYP21A2 OGG1 CYP11B1;CYP11B2 NTHL1 NEIL3 NEIL1 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A SNF8 VPS37B UBAP1 VPS25 VPS28 CHMP5 TUFM CSNK1A1 OPN1SW CLEC4M;CD209-2 ITGB1 CYFIP1 CUX1 FGFR1OP2 MYO18A CPSF6 RHOG ELMO2 DOCK2 DOCK1 RAB7A ERBIN PDGFRB TRAT1 NTRK3 PIK3AP1 PPP1CB TTR PPP1CA KIF5B MPI PMM2 PTK2 ABCA3 DAG1 PRKAR2A PABPC1;PABPC3 NRP1 NCK1 CXCR4 MYO9B SLC35C1 DHDDS DPM1 DPM2 DPM3 GNE NEU1 CTSA SLC35A1 NUS1 SRD5A3 GFPT1 DOLK TMPRSS2 ACE2 ELK1 EREG BTC EPGN HBEGF SQSTM1 ARF1 HSPA8 PPFIBP1 MTRR AHCY MTR-1 MAT1A COMT KLB IRS1 PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 ABCC2 IL6R KEAP1 UBE2L6 HERC5 MCL1 IL22 ATG7 LMO7 CUL5 UBA7 UBA6 UBA5 UBR4 UBA3 UBA1 RNF213-2 VHL HGF PATJ MPP5 CYP27A1 CRB3 GSS CYP7B1 CTBP2 CTBP1 TCN2 NCKAP1 DUSP10 WASF1-1 DUSP8 DUSP9 CYBA BCR NOXO1 NCKAP1L WASF2 BAIAP2 ABI2 ABI1 NOXA1 NOX1 C1QBP DNMT3B DNMT3A PRIM2 DNMT1 PRIM1 POLA1 POLA2 PDGFRA SLC5A1-1 SLC2A2 SLC6A3 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SLC22A18 HCK CD8B;CD8B2 ELMO1 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW UPK1A EPCAM CYFIP2 WIPF1 WIPF2 WIPF3 PYCARD CYSLTR1 CYSLTR2 GNAT3 C3AR1 GGT1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK DPEP2 DPEP1 GNAZ MEFV NCKIPSD FCGR3A;FCGR3B LRAT PRKAR2B DVL1 PLCG2 DVL2 DVL3 NLRP3 GGT5 MYO5A ARPC4 ARPC5 RBP4 ARPC2 ARPC3 ACTR3-1 ARPC1B RBP1 ARPC1A WASL PSTPIP1 CTSG ACTR2 SYK FGR ADORA2B RDH12 ADCY4 GNAI3 WAS ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 GNAI2 ADCY5 NT5E FCGR1A WASF3 MYO10 P2RX7 P2RX4 MYO1C SUGT1 TRIM27 TNKS TNKS2 LIG1 STRA6 RLBP1 CD9 NRG1 RIPK2 MYD88 SLC24A1 IRAK4 DUSP6 DUSP7 TLR10 TLR5 NOD1 NOD2 IRAK2 TENT4A AKAP9-1 KIAA1549 MPRIP TRIM24 FXR1-1 AGTRAP AP3B1 SND1 ESRP1 KDM7A FAM114A2 ZC3HAV1 TRAK1 LMNA AGK QKI CLCN6 FAM131B AGGF1 EXOC1 GBF1 TRIP11 CEP43 RNF43 DKK1 DKK2 DKK4 GCC2 GOLGA4 KREMEN1 KREMEN2 LRP5 LRP6 COG1 KLC1 GP9 GP1BB GP5 XRN1 STAT5A STAT5B PIM1 NOX4 GRB2 CYP2U1 CYP1B1 KDM1A FKBP4 DDX5 KANK1 PTGES3-1 SPTBN1 MSN PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 FGFR2 SKP1 CHUK PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 PSMB6 PSMB7 PSMB4 ATIC PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NFKBIB HDAC4 UBE2I NR3C1 ESR1 SUMO1 MRE11 BRCA1 BRCA2 KAT5 EXO1 ACAT1 NBN UGT1A1;UGT1A6 TOPBP1 SLC35D1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 FEN1 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 RHNO1 EIF4A2 BLM EIF4A1 RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ATM RAD1 RAD9B RAD9A ATR ANAPC15 ANAPC16 ANAPC7 UBE2C H2AC16;H2AC11 UBE2E1 UBE2D1 ANAPC10 UNC93B1 ANAPC11 TLR8 TLR7 CCNB1 CDC23 UBE2S TLR3 CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 C1S SH3GL3 SH3KBP1 SRC MBL2-1 CTNND1 MASP1 STAM CBL CDH1 HGS CGAS CTNNB1 STAM2 MET LRRFIP1 EPS15 IRF7 CBLL1 SH3GL2 SH3GL1 DHX9 YWHAB XRCC6 NRAS XRCC5 RAP1A MAP2K2;MAP2K1 STING1 MAPK1 HRAS TFG MAPK3 BRAF FRS2 MAPK14 F5 F8 RPS6KB2 SOS1 CRK SHC1-1 SLC25A15 CPS1 ARG1 MRAS ASL NAGS SHOC2 NMRAL1 ASS1 OTC SEC31A HDAC3 LY96 HBD;HBB F11 XPO1 SFTPB EP300 HMOX1 MED1 CREBBP APOA1 CYP19A1 HBA2;HBA1 NCOR1 TBL1XR1 TLR4 NFE2L2 PPIA CALM3;CALM1 FKBP1A YWHAE CAST APP JUN FASLG CDC25C SOD2 FOXO3 CDC25A LMNB1 CDC25B GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 SLC5A7 NOTCH1 RBX1 IHH GNGT1 SHH WNT5A GNAS-1 DHH GNG10 ABCD1 ETV6 GNG2 GNG5 FIP1L1 GNG4 BIN2 KDR GNG8 FZD5 FZD4 WNT3A FZD7 FZD6 FZD8 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 SPRED3 SPRED2 SPRED1 CUL3 LIG4 NF1 XRCC4 IDUA HEXB NCAN HEXA BGN DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB RB1 CDKN1C CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 DAXX ATRX ARID4A TFDP1 ARID4B FNTA CDK6 TFDP2 BLNK HMG20B CCNE2 JAK3 CDK4 IL1R1 CCNE1 IFNGR1 CDK2 FLT3 IFNGR2 SIGMAR1 NUP107 TYK2 SAP30 BRMS1 IFNAR1 PHF21A CD79B PPP1CC CD79A PPP2R1B SAP30L PPP2R1A S1PR1 SAP18 SUDS3 CRBN STAT2 DYNC1LI1 RCOR1 FNTB;CHURC1-FNTB CLIP1 CPSF2-1 DYNC1LI2 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T WDR33 NUDT21 CLP1 PCF11 NUP160 PAPOLA SYMPK NUP85 RPS27 PPP2CB;PPP2CA PPP2R5E SEC13 NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SFTPC DYNC1I2 FGFR1 SLC12A3 NUP43 SLC12A1 DYNC1I1 SLC12A6 RANBP2 DYNC1H1 BAD CASP9 TAOK1 NUP37 MSH6 MSH2 MSH3 PMS2 MLH1 AVPR1B AVPR2 AVP AVPR1A TJP1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F CTR9 WDR61 POLR2G POLR2H RTF1 CDC73 POLR2I POLR2L RNGTT LEO1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 FDX1 FDXR PAF1 H2AC14 AKT2 MYC AKT3 AKT1 PROS1 CLDN1 CSNK2A2 CD33-1 CSNK2B MRC1 EMC4 HSPA5 TIMD4 RPN2 MERTK MAPKAP1 AXL TYRO3 RPN1 PIK3R3 MAPRE3 GAS6 PIK3R2 LY6E PIK3R1 PIK3R6 PIK3R5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CYP4F22 LYN YES1 ERLIN1 ERLIN2 MOV10 AGO4 H2AC20 AGO2 CD28 H2AB2;H2AB3;H2AB1 EZH2 CD3G ASH2L IRF4 MAGT1 RAC1 JAK1 VAV1 H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 DERL3 DERL1 DERL2 OS9 RICTOR PAK2 BRD4 SUZ12 H2BC5 STAT1 STAT3 MIB2 H2BC1 VCP-1 CD86 TUSC3 CD80 ANO8 NEK2 ANO9 H2AC4 ANO6 ANO4 TMEM258 ANO5 ANO2 ANO3 ANO1 SEL1L OST4 NFKB2 OSTC PCCA STT3A ANO10 MMAA PCCB STT3B MMUT RNF185 PRR5 GSK3B DPY30 PIK3CD PIK3CB PIK3CG MMAB H2BC21 WDR5 MMACHC MMADHC MLST8 YWHAG EED PDPK1 H2AZ2;H2AZ1 DDOST PIK3CA DAD1 LCK RNF5 CDC42 ERLEC1 RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FYN CSK CYP24A1 RBBP7 TCF7L2 PTPN11 MTOR TNRC6C CD4 H2BC15;H2BC3;H2BC11;H2BC12 PTPN6 PDCD1 CCNK CCNT1 BTD ELL GTF2B ELOC-1 TAF7L ELOA ELOB HLCS NELFB NMT2 NELFA NELFCD NRG2 NELFE NRG3 SUPT16H NRG4 TBP NCBP1 CBLIF GTF2A1 GTF2A2 CTDP1 CD320 TAF9 GTF2E1 GTF2E2 SUPT4H1-1 TAF15 TAF12 TAF13 TAF10 BCL2A1 TAF11 SSRP1 CDK9 NCBP2-1 CCNT2-1 TAF8 TCEA1 TAF4B TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GJA1 CFTR RCC1 NMT1 CCR5 RANBP1 CYP2R1 TP53 S100A9 S100A8 ECHS1 TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 PROC DDX58 NUP205 IFIH1 NUP188 RNF135 SIKE1 PSIP1 AAAS MAVS TRIM25 NUP42 NUP62 SRPK2 TPR SRPK1 BANF1 CX3CR1 NUP88 RAB5B RAE1 RAB5C IGF1R KPNA1 NCL-1 NDC1 NUP214 RAB5A NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 RHAG SLC4A1 NUP54 SLC25A5 SLC25A4 SLC25A6 RPL4 RPL30 RPL3 CALR-1 RPL32 HSPA1A;HSPA1B RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 KPNA7 RPL35 RPL38 KPNA5 KPNA2 RPS11 KPNA3 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPL10;RPL10L-1 KPNA4-1 CPSF4 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 TPM4 RPLP0 TPM3 CLTC CLTA RPS4X RPL7A GBP2;GBP3;GBP1 RPLP2 RPL36-1 HSP90AA1 PARP1 RPS3A PTPN12 DNAJC3-1 CANX GALNT12 RPL13A-1 SEMA5A POMT2 RPL11 RPS27L SPON2 RPS15A SEMA5B SPON1 RPL14 THSD7B RPS3 POMT1 RPL13 RPL12-1 ADAMTSL3;ADAMTSL1 ADAMTSL1 RPS2 LFNG RPL18 ADAMTS4 RPL17 ADAMTS5 RPL19 C1GALT1C1 RPL35A ADAMTS2 RPL23A ADAMTS3 PABPN1-1 ADAMTSL5 RPL22L1 ADAMTSL4 FAU ADAMTS1 RAN ADAMTSL2 RPL26L1 MUC12 ALG14 MUC13 MUC15 THSD7A ADAMTS8 LARGE1 HHAT ADAMTS9 RUNX1 ADAMTS6 ADAMTS7 SBSPON MUC3A POMGNT1 MUC5AC ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 FASN ADAMTS16 ADAMTS15 MUC1 ADAMTS14 MUC2 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 U2AF1L5;U2AF1 MUC6 EIF4A3 GALNT3 MUC17 C1GALT1 MUC5B MUC20 MUC21 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 DHX38 SRSF11 SRSF4-1 ALYREF RNPS1 F2 FN1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 B2M AP1M2 AP1M1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CYP27B1 TRAF6 ZAP70 UBE2V1 UBE2D3;UBE2D2 UBE2N TAB3 TAB2 TAB1 MCCC2 MCCC1 PPM1K AUH IVD HIBCH AMER1 YWHAH TPST2 TPST1 F9 YWHAZ KIT HDAC1 MARK3 POMC F10 CAV1 GGCX SLC5A5 ELAVL1 VAV3 C4BPA TPMT C4BPB CLU VAV2 IMPDH1 CD19 IMPDH2 HPRT1 SERPING1 HSP90AB1 ROCK1 ROCK2 ACTG1 CPSF7 CDC37 HNRNPC VIM RBMX CYP17A1 FURIN TGFBR1-1 H2BC18 TGFBR2 RPTOR TSC2 BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG HGSNAT ISCU AKT1S1 NAPEPLD SLC2A9 PGK1 EIF4E EIF4G1 ACY1;ABHD14A-ACY1 SNAP25 CARS1 SV2C SYT2 SV2B SYT1 SV2A VAMP1 STX1A VAMP2 APC SLC34A2 SLC34A1 ACOT2;ACOT1 NOS2 SEC23A SAR1B ACACA SCAP GBP6 GRPEL1 SEC24B HYOU1 SEC24A MED19 MED18 PQBP1 MED11 SEC24D-1 MED29 MED22 MED21 SP1 ATL2 SRRT VPS33A VPS33B SEC24C ZCRB1 SNRNP200 CORO1A G3BP1 G3BP2 FUS NACA BCAS2 CTNNBL1 PRCC HNRNPA0 TRADD HNRNPA3 CASP8 GPKOW CASP1 CDC5L KDELR1 CCAR1 CD2BP2 PCBP1 GZMH;GZMB-1 PCBP2 PDCD6IP RIPK3 RBM10 MED13L IL18 BST2 TRAF2 IL1A RETREG1 SUGP1 IL1B DHX15 UFD1 CHMP4C DHX16 CHMP4B ARIH1 SFTPD CHMP3 CHMP4A BCAP31 PEX19 NLRP12 CHMP6 HNRNPA2B1 CHMP7 IL17F IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH HMGB1-1 PPIG RIPK1 PPIB RTN3 DDX46 FADD DDX42 SUN2 GSDMD CASP5;CASP4 RBM17 ITCH DYNLT1 CHMP2B BUD31 CHMP2A MMP9 RBM22 DDX23 RRBP1 GBP7;GBP4 GSDME SLC22A5 SMNDC1 CNBP-1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM NPLOC4 HNRNPK HNRNPF HNRNPD CLINT1 HNRNPA1-1 SF3B4 SF3B5 MED28-1 SF3B2 SF3B3 ISY1;ISY1-RAB43 SF3B6 SF3B1 SF3A3 DDX3X-1 SF3A1 WDR48 SF3A2 XAB2 PHF5A AUP1 IPO7 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 AHCYL1 P4HA2 P4HA3 RCAN3 EIF4G3 EIF4G2 EIF4E3 PRKACA-1 DUSP16 PTBP1 SFPQ-1 PLRG1 ABCC9 ATP1B2 LARP1-1 ATP1B1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C CAMK2B SNRNP40 CAMK2D VPS41 CAMK2A DNAJA2 ATP1A4 VPS45 ITPR1 PPIL3 ITPR2 PPIL4 ATP1A3 PPIL6 ATP1A2 SRRM2 ITPR3 AQR CRNKL1 ATP1A1 NMI PRPF19 CAMK2G CHMP1A FMO3 KCNJ11 TOMM70 ATP1B3-1 IL17RC IL17RA TLR1 HNRNPH1 FXYD2;FXYD6-FXYD2 HNRNPH2 TLR6 TLR2 FXYD4 SPCS3 FXYD3 SPCS2 SPCS1 FXYD1 CWC25 FXYD6 PPIL1-1 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 PDZD3 CBX1 MAP2K4 CWC15 DNAJC10 ELAVL2 RBM5 LTF MDM2-2 TXN MAP2K7 IL6 CEBPB MAPK9 MAPK8 IFNB1-4 CDKN2A NTRK2 BDNF GAB1 FRS3 NTF4 NTF3 PLCG1 EGF AREG BCL2L1 EEF1G EEF1A1 S100A1 CD36 EEF2 JAG2 TIRAP JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SMN2;SMN1 GEMIN4 GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX20 SNRPE-2 SNRPG-2 ABCC8 C3-1 GCLC LOC110384692;C4A;C4B_2;C4B GCLM GUCY2C PORCN WDCP SI LCT SLC35A3 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC6A20 ZMYM2 SLC6A19 SLC36A2 SLC6A14 SLC7A7 SLC7A9 ST6GALNAC2 PRKCSH ZDHHC20 MGAT4A-1 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS GOLGA7-1 MGAT4C ZDHHC9 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 CAMK4 IL10 CD163 PLK2 RHBDF2 MYH9 RBPJ TXNIP CCNC-1 SFN MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 MED27 MED26 MED23 MED25 MED24 MED20 EGFR MBD3 GATAD2B GATAD2A FGFR3 SYVN1 KMT2D FOXO4 MED30 G6PC1 PTEN ITGA4 MC2R TRIM28 TGFA SNW1 FOXO1-1 GCK MED31-1 MAMLD1 IRAK1 SMAD2;SMAD3 CHD4 CHD3 YWHAQ SLC17A8 MTA2 REST KRAS MAML2 MAML1 PAH JUNB MED8 MED4 MED6 MED7 NEDD4L BAG4 NCOR2 KAT2B KAT2A TAL1 F12 KLKB1 OPLAH GPS2 ITGA2B NRBP1 NOTCH2 NOTCH3 NOTCH4 ABL1 CDK8 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage GSDMD CASP3 CASP5;CASP4 IL18 IL1B TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX CEBPB CDKN2A AGO3;AGO1 LEF1 EHMT2 EHMT1 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 TCF7L2 ANAPC11 TNRC6A-1 CDC23 UBE2S CDC26 TNRC6C RELA CDC16 CSF1R CDC27 ANAPC4 ANAPC5 TNRC6B ANAPC1 ANAPC2 FZR1 NFKB1 MOV10 AGO4 CCND1 CTNNB1 TP53 IL6 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) MSMO1 HSD17B7 TM7SF2 NSDHL SC5D DHCR7 EBP DHCR24 CYP51A1 LBR LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism DLST DHTKD1 ALDH7A1 DLD HYKK SLC25A21 CRYM AASS PHYKPL PIPOX GCDH AADAT REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade VWF SERPING1 F5 F8 PROC F7 GPC1 APP F2R F9 HSPG2 GPC3 PROS1 PF4;PF4V1-1 KNG1 GPC2 SDC4 SERPINC1 GPC5 SDC2 GPC4 F3 SDC3 GPC6 GP9 GP1BB GP5 AGRN SERPINE2 SERPINA5 THBD SMPD1 CD177 F10 ANO6 PROCR F11 ANO5 SDC1 SERPINE1 F12 KLKB1 ADAMTS13 SERPIND1 F2 GP1BA DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing OGG1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 SYT10 MAPK1 ARNT2 MAPK3 RBFOX3 NR3C1 FOS GEM AGO3;AGO1 BDNF RET TNRC6A-1 MDM2-2 IQSEC3 TNRC6C CDK5 KCNIP3 TNRC6B ARNT CDK5R1 ARNTL REST XPO1 SRF MOV10 AGO4 AGO2 NPAS4 NAMPT PLK2 INS;INS-IGF2 CREBBP STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication RNASEH1-1 EXOG SSBP1 POLRMT POLG2 TOP3A POLG TWNK MGME1 COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation COL4A3 COL4A6 COL20A1 COL9A1 COL8A2 COL8A1 COL6A3 COL4A5 COL21A1 COL9A3 COL6A6 COL6A5 COL9A2 MMP7 COLGALT2 BMP1 PLOD3 TLL2 PLOD2 TLL1 PLOD1 COLGALT1 P3H2 P3H1 CTSS PCOLCE P3H3 PCOLCE2 CTSB SERPINH1 CRTAP P4HA1 P4HA2 P4HA3 PLEC P4HB LAMB3 LAMA3 LAMC2 LOX LOXL3 LOXL4 ADAMTS2 LOXL1 ADAMTS3 LOXL2 COL1A1 COL1A2 MMP20 ITGB4 COL17A1 COL18A1 CTSV;CTSL COL15A1 COL16A1 COL13A1 COL14A1 ITGA6 MMP3 COL11A1 COL12A1 COL11A2 COL19A1 COL10A1 PPIB COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 ADAMTS14 COL3A1 MMP9 COL2A1 COL5A1 COL4A2 CD151 COL4A1 COL7A1 COL6A2 COL5A3 COL4A4 MMP13 COL6A1 PXDN COL5A2 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRND CHRNG CHRNE CHRNB2 CHRNB4 CHRNA3 CHRNA4 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 RAC1 HGF RAPGEF1 GAB1 MET CRK DOCK7 CRKL RAP1B RAP1A FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate XYLB DCXR AKR1A1 SORD CRYL1 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions TJP1 CBFB OCLN-1 RUNX1 CLDN5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 LGALS3 SOX9 HIVEP3 STAT1 HDAC6 CCNB1 ITGBL1 CDK1 RB1 SRC CDKN1A TWIST2 CCND1 SATB2 SKP2 CDK4 GSK3B MAPK1 MAPK3 MSX2 SMAD1 SMAD4 SMURF1 PPARGC1B SMAD6 YAP1-1 BMP2 COL1A1 CBFB RUNX1 UCMA HDAC3 RBM14 HEY1 HEY2 HES1 PPARGC1A MMP13 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 GLI3 CUL1 GLI2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 ZNF521 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 MAF PSMC3 IHH PSMC4 PSMC1 DLX5 DLX6 HDAC4 WWP1 NR3C1 ESR1 AR AKT2 SP7 AKT3 AKT1 NKX3-2 WWTR1 ABL1 YES1 HAND2 ITGA5 PPM1D ESRRA BAX STUB1 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation GRB10 INSR INS;INS-IGF2 IRS1 IRS2 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling LRRC14 USP14 NLRX1 IKBKB NLRC5 RPS27A IKBKG UBB;UBC N4BP1 CASP8 CHUK USP18;USP41 TP53 TRAF6 IKBIP TRAF2 UBA52 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions FLNA TESK1 RSU1 PARVA PARVB ARHGEF6 LIMS4;LIMS1 FLNC LIMS2 VASP FBLIM1 ILK FERMT2 PXN ITGB1 ACTN1 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT COMT LRTOMT MAOA FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT5 CCT3 CCT4 CCT2 TUBB2B;TUBB2A TUBB4B CCT6A TUBB4A;TUBB;TUBB8B;TUBB8 TUBA4A TCP1 TUBA8 CCT6B TUBB3;TUBB6 TUBAL3 TUBA1C TUBA1A TUBB1 CCT8 TUBA3E;TUBA3C-1 CCT7 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP CASP8 FADD TNFSF10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FAS FASLG TRAF2 RIPK1 TRADD FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation FGF9 FGF20 FGF18 FGF1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling SOCS3 JAK2 TYK2 UBE2D3-1 JAK1 SYK CSF3 RNF7 LYN CSF3R ELOC-1 HCK RPS27A UBB;UBC ELOB CUL5 STAT5A STAT5B SOCS1 UBA52 STAT1 UBE2D1 STAT3 UBE2D3;UBE2D2 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway CTSS LNPEP CTSV;CTSL B2M HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis CAD UMPS DHODH ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones MBTPS2 MBTPS1 ATF6B HSPA5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen GP1BB ITGA10 GP5 ITGA2 ITGA1 VWF FCER1G GP6 LYN ADAMTS13 FYN ITGB1 GP1BA GP9 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism PDK2 PDK1 GSTZ1 PDHX PDHA1 SIRT4 ARMC8 PDP1 MKLN1 GID4 PDP2 ME1 GID8 UBA52 DLD RPS27A WDR26 UBB;UBC PDHB RMND5B LDHA MAEA RMND5A PDPR PDK4 PDK3 NEK1 RANBP9 DLAT INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing NFKB1 CASP1 GSDMD RELA NFKB2 CTSG IL18 IL1A IL1B KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins KIF22 KIF3B KIF3A KIF26A KIF3C CENPE KIF4B;KIF4A KIF12 KIF19 KIF13B KIF1C KIF21A RACGAP1 KIF1B KIF21B KIF18A KIF1A KIF25 KIF6 KIF27 KIF9 KIFC2 KIFC1 KIFAP3 KIF16B KIF20B KIF20A KLC1 KLC4 KLC3 KIF18B KLC2 KIF26B KIF5B KIF11 KIF15 KIF5A KIF2A KIF2C KIF23 KIF2B VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus HSPA1A;HSPA1B METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines SRM PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 NQO1 PSMA4 PSMA1 PSMD12 OAZ1 PSMD11 PSMD14 PSMD13 PSMA7 PAOX PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 ODC1 PSMB1 ADRM1 AGMAT PSMA2-1 SAT1 SEM1 PSMC5 PSMC6 SMS AZIN2 PSMC3 PSMC4 PSMC1 AMD1 AZIN1-2 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation ST6GALNAC2 PRKCSH DERL1 MGAT4A-1 DERL2 OS9 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 VCP-1 MOGS TUSC3 MGAT4C MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 TMEM258 ARF4-1 SEL1L CSNK1D OST4 CGA OSTC STT3A INS;INS-IGF2 STT3B RNF185 ARFGAP2 MCFD2 SERPINA1 PPP6C TFG PPP6R1 PPP6R3 CTSC TMED2-1 TRAPPC2L TRAPPC2;TRAPPC2B DDOST LMAN1L DPAGT1 ALG8 F5 DAD1 ALG9 TRAPPC6A ALG6 F8 ALG2 TBC1D20 ALG3 TRAPPC6B ALG12 GORASP1 ALG1 PREB MPDU1 SEC22B RNF5 RFT1 SEC22A SEC22C RAB1A TMED10 STX17 LMAN2L RAB1B GOSR2 USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC3 TRAPPC1 TRAPPC4 TRAPPC10 TRAPPC5 TRAPPC9 ARFGAP1 ACTR1A SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 MAN1A2 MAN1C1 MAN1A1 DCTN2 DCTN3 GOLGA2 GBF1 MIA3 MVD SEC23A SYVN1 SAR1B GOLGB1 ALG11 SEC24B SEC24A SEC24D-1 EDEM1-1 SEC24C NAPA KDELR3 NAPB DCTN1 KDELR1 NAPG DCTN6 DCTN5 COG8 DCTN4 COG7 CD55 COG6 CAPZA3 COG5 ACTR10 COG4 COG3 COG2 COG1 ARFGAP3 COL7A1 CALR-1 LHB LMAN1 STX5 YKT6 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 AMFR RNF103 TRIM13 TGFA UBXN1 GLB1 FUCA1 GMPPB PMM1 MPI CHST8 GMPPA PMM2 ARF5 ARCN1 CANX DYNC1LI1 DYNC1LI2 ALG10;ALG10B PDIA3 KDELR2 SPTAN1 ALG14 CAPZB ANK2 MIA2 ANK3 ANK1 SPTB ST3GAL6 ENGASE B4GALNT2 CAPZA1 CAPZA2 ST6GALNAC1 CMAS FUT6;FUT5;FUT3 NANP FPGT NGLY1 PGM3 GNPNAT1 SEC13 SPTBN4 NANS SPTBN5 GFUS NUDT14 SPTA1 ST6GAL2 ALG5 GOSR1 SLC35C1 RENBP SPTBN1 DHDDS SPTBN2 DPM1 DPM2 DPM3 ST6GALNAC5 GNE CHST10 UAP1 NPL NEU2 ASGR1 NEU3 ASGR2 DYNC1I2 NEU4 DHRSX COPZ2 GMDS COPZ1 AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 DYNC1I1 ST8SIA6 CTSA SLC35A1 NUS1 ST8SIA1 DYNC1H1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK SLC17A5 FCSK DOLPP1 UBA52 AREG NSF GRIA1 BET1L ARF1 CTSZ RPS27A UBB;UBC PSMC1 UMOD MLEC TMED3 TMED7 TMED9 COPG2 RAD23B COPG1 COPB2 COPA COPB1 MAN2A2 TMEM115 COPE B4GALT2 B4GALT3 B4GALT1 HK1 RPN2 RPN1 B4GALT6 MGAT3 B4GALT4 MANEA B4GALT5 ST6GALNAC6 MAGT1 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling SOCS3 PTPN11 JAK2 TYK2 IL6 JAK1 IL6ST STAT1 STAT3 IL6R CBL SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL MAPK1 MAPK3 LEFTY2;LEFTY1 GDF1 ACVR2A SMAD2;SMAD3 SMAD4 FURIN PCSK6 ACVR1C CFC1;CFC1B ACVR1B FOXO3 TDGF1 FOXH1 ACVR2B DRAP1 NODAL DAND5 CER1 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation DNMT3L H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AJ UHRF1 H2AC20 H2AC14 H2AB2;H2AB3;H2AB1 DNMT3B DNMT3A DNMT1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response CASP7 MAPK1 CASP3 CASP9 MAPK3 AVEN APAF1 DIABLO-1 UACA XIAP CYCS-1 APIP REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling SOCS3 IFNGR2 PTPN11 JAK2 JAK1 PTPN6 PTPN1 PIAS1 SOCS1 IFNG SUMO1 IFNGR1 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 PLCG1 FGF18 FGF10 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily SSRP1 H2AJ SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 H2BC5 PHF5A H2BC1 SNRPN CHERP H2AC4 TCF12 SNRPD2 SNRPD1 SNRPA1 SNRPD3 PUF60 SNRPB2 SNRPF SNRPB SNRPE-2 SNRPG-2 CTR9 CHD1 WDR61 H2BC21 RTF1 CDC73 LEO1 H2AZ2;H2AZ1 H2AC14 PAF1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 DHX15 H2BC15;H2BC3;H2BC11;H2BC12 MYOG MYOD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TCF4 DDX46 DDX42 H2AC20 RBM17 SUPT16H H2AB2;H2AB3;H2AB1 SMNDC1 CHD2 U2SURP GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling NRG2 GRB7 NRG1 ERBB2 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal FTO ALKBH5 ALKBH2 ASCC1 ASCC2 MGMT ASCC3 ALKBH3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway TBCD TUBB2B;TUBB2A TBCC TBCB TBCA TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TUBA4A TBCE TUBA8 TUBB3;TUBB6 TUBAL3 TUBA1C TUBA1A ARL2 TUBB1 TUBA3E;TUBA3C-1 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand FGB S100A1 FGA CD36 S100A9 FGG TLR4 S100A8 LY96 TLR1 TLR6 HMGB1-1 TLR2 GSDMD LBP APOB CD14 GSDME TLR7 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells MPO LPO ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases SPOCK3 CTSG KLK3;KLK2 MMP1 CMA1 MMP7 MMP25 CTRB1;CTRB2 MMP24 MMP10 COL18A1 CTSV;CTSL MMP11 MMP15 MMP17 TIMP2 MMP3 TPSAB1;TPSB2;TPSD1 CTSK TIMP1 ELANE MMP14 PRSS3;PRSS2;PRSS1 MMP16 FURIN KLKB1 MMP2 MMP9 PLG MMP13 MMP8 INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion FURIN ANO8 ANO9 TMPRSS2 ANO10 ANO6 ACE2 ANO4 ANO5 ANO2 ANO3 ANO1 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 PTPN11 PIK3R1 FRS2 PIK3CA FGF1 FGF2 FGF4 GAB1 FGF9 FGF20 FGF23 FGF16 FGF18 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 RFC5 RFC3 RPA1 RFC4 RPA2 REV3L RFC1 RFC2 REV1 MAD2L2 RPA3 RPS27A UBB;UBC PCNA UBA52 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade GNB1 PPEF1 METAP2 GUCY2D PRKCA PDE6B PDE6A FNTB;CHURC1-FNTB CALM3;CALM1 CAMKMT RGS9BP NMT1 LOC118142757;GUCA1A GRK1 GRK7 SLC24A1 SAG CNGA1 NMT2 RHO GUCA1C GNAT1 CNGB1 RCVRN PRKCQ FNTA GNGT1 METAP1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection PSIP1 PPIA BANF1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage CASP7 CASP3 CASP9 APAF1 XIAP CYCS-1 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation EGFR PTPN12 ARHGEF7 PTPN3 CDC42 TGFA EGF UBA52 AREG EREG BTC EPGN SPRY2 HBEGF PTPRK EPS15L1 EPN1 SH3GL3 SH3KBP1 SPRY1 RPS27A UBB;UBC STAM CBL HGS STAM2 EPS15 SH3GL2 SH3GL1 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity RHOA ROBO1 MYO9B SLIT2 VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance APOC4 APOB APOBR APOC1 LSR VLDLR CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE ITGB3BP RAC1 ARHGEF26 PSENEN PSEN2 PSEN1 KALRN MAPK8 APH1A NCSTN APH1B VAV1 MCF2 BAD YWHAE TIAM1 UBA52 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 BCL2L11 NGFR ARHGEF12 SQSTM1 ARHGEF17 ARHGEF3 ARHGEF1 ARHGEF2 RPS27A UBB;UBC ECT2 RASGRF2 CASP3 MAGED1 NET1 VAV3 ARHGEF40 PLEKHG2 ARHGEF15 VAV2 PLEKHG5 ARHGEF19 TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 NGF FGD1 FGD2 ARHGEF18 FGD3 GNA13 FGD4 ARHGEF33 ARHGEF37 SOS1 ARHGEF39 ARHGEF38 BEX3 SOS2 TRIO ITSN1 CASP2 ABR PREX1 MCF2L ARHGEF16 TRAF6 AATF ARHGEF5 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis TMEM126B NDUFC2;NDUFC2-KCTD14 NDUFB8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 SFXN4 NDUFAF3 NDUFA5 NDUFAF1 NDUFS5-1 TMEM186 HSPA9 ACAD9 DMAC2 TIMMDC1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 NDUFA10 OXA1L NDUFB10 NDUFB11 NDUFV3 NDUFV2 NDUFV1 TMEM126A-1 HSCB NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS2 NDUFS1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFAB1 ECSIT NDUFS3 PYURF HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation HBA2;HBA1 HBD;HBB MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family CLEC4E MUC5B CLEC6A MUC20 MUC21 FCER1G MUC3A SYK MUC5AC LYN MUC1 MUC2 PLCG2 FYN MUC7 MUC4 MUC12 MUC6 CLEC4A MUC13 MUC17 CLEC4D MUC15 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy TOMM40 MAP1LC3B2;MAP1LC3B-1 TOMM70 TBK1 TOMM7 OPTN-1 UBA52 MAP1LC3A MTERF3 ATG9A TOMM20 UBE2D3-1 ATG12-1 SQSTM1 TOMM22 ATG5 PRKN VDAC2-1 VDAC3 RPS27A UBB;UBC VDAC1 MFN1 MFN2 UBE2V1 UBE2D3;UBE2D2 PINK1 UBE2N RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation POLR2E POLR2F POLR1C POLR2H POLR1D RRN3 POLR2L ERCC6 GTF2H1 TTF1 GTF2H3 UBTF GTF2H4 MBD3 CDK7 POLR1A ERCC3 POLR1B ERCC2 POLR1E POLR1F MNAT1 EHMT2 POLR1G POLR1H GATAD2B TAF1D GATAD2A HDAC2 TAF1B RBBP4 TAF1C TAF1A RBBP7 HDAC1 CHD4 CHD3 MTA1 MTA3 MTA2 KAT2B KAT2A TBP GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation GLI3 CBFB MAPK1 HDAC3 UCMA MAPK3 ZNF521 RB1 WWTR1 SRC ABL1 YES1 AR HEY1 HEY2 HES1 SATB2 MAF SP7 YAP1-1 HDAC6 COL1A1 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation BMP4 NANOG;NANOGP8 SOX2 POU5F1;POU5F1B TRIM33 TCF7 LEF1 TBPL2 SMAD2;SMAD3 CTNNB1 SMAD4 EOMES TBXT GSC MIXL1 FOXH1 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease GAB1 HRAS SOS1 PIK3R1 FRS2 PLCG1 PIK3CA NRAS FGFR4 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins SYT10 GRIN2B SYT2 SYT1 STX1A CASK LIN7A LIN7C LIN7B EPB41L1 GRIN2C HOMER3 EPB41 GRIN1 STXBP1 GRIN2D EPB41L5 GRIN2A DBNL EPB41L2 DLG2 HOMER1 HOMER2 SIPA1L1 DLGAP1 DLGAP3 DLGAP4 BEGAIN APBA3 APBA2 SYT7 SHARPIN LRRTM3 LRRTM4 DLG3 LRRTM1 DLG4 LRRTM2 NRXN1;NRXN3;NRXN2 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN3 NRXN2 PDLIM5 NLGN4X;NLGN4Y SYT12 APBA1 SYT9 GRM1 GRM5 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions CLDN11 CLDN10 CLDN15 CLDN14 PATJ CLDN12 MPP5 CLDN19 CLDN18 CRB3 CLDN17 CLDN5 CLDN16 F11R PARD6A PARD3 CLDN22;CLDN24-1 CLDN1 PARD6G PARD6B PRKCI CLDN2 CLDN6 CLDN4 CLDN3 CLDN9 CLDN8 CLDN7 CLDN23-1 CLDN20 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements PSMD8 PSMD6 PSMD7 PSMD2 HSPB1 PSMD3 PSMD1 EIF4G1 PSMC2-1 PSMA5 PRKCD YWHAZ PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 DIS3 PARN PSMA7 EXOSC7 PSMB6 EXOSC6 PSMB7 EXOSC5 PSMB4 EXOSC4 PSMB5 EXOSC9 KHSRP PSMB2 PSMB3 EXOSC8 PSMB1 EXOSC3 RPS27A EXOSC2 XRN1 EXOSC1 UBB;UBC DCP2-1 ADRM1 DCP1A PSMA2-1 SET-1 HSPA8 SEM1 ELAVL1 ANP32A;ANP32D PSMC5 PSMC6 PSMC3 PSMC4 ZFP36 PSMC1 YWHAB PRKCA MAPK14 MAPK11 PABPC1;PABPC3 MAPKAPK2 AKT1 NUP214 ZFP36L1 XPO1 TNPO1 HSPA1A;HSPA1B BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BCL2L11 PMAIP1 BAD BBC3 BMF BCL2 BID STAT3 BCL2L1 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer TP53 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling NTRK2 NTF4 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CD JAK2 PIK3CB PIK3CG GAB1 PIK3R1 EPOR PIK3R5 LYN PIK3CA EPO IRS2 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis RAC1 VAV1 HCK ELMO1 CYFIP2 WIPF1 WIPF2 WIPF3 BTK NCKIPSD FCGR3A;FCGR3B VAV3 MYH9 MYO5A ARPC4 ARPC5 PTK2 ARPC2 ARPC3 MAPK1 ACTR3-1 ARPC1B VAV2 ARPC1A WASL MAPK3 ACTR2 SYK FGR ACTB-1 NCKAP1 WASF1-1 WAS CDC42 CRK ACTG1 NCK1 FYN WASF3 MYO10 CYFIP1 MYO1C NCKAP1L WASF2 LYN MYO9B ABL1 BAIAP2 YES1 ABI2 ABI1 ELMO2 CD3G DOCK1 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TYW1;TYW1B TRMT5 TRMT12 LCMT2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS JAK2 RAPGEF1 HRAS SOS1 EPOR SHC1-1 LYN EPO VAV1 IRS2 CRKL NRAS DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 CBLIF CUBN AMN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation MAP2K2;MAP2K1 JAK2 BRAP HRAS CAMK2G KSR1 BRAF PPP1CC PPP2R1B PPP2R1A RAF1 MAP3K11 CALM3;CALM1 MRAS SHOC2 PPP1CB MARK3 PPP2CB;PPP2CA SRC PPP2R5E PPP2R5B PPP2R5A PPP2R5D CAMK2B PPP2R5C CAMK2D CAMK2A ARAF YWHAB PHB NRAS REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins SP1 HEYL AGO3;AGO1 SOX10 TNRC6A-1 CDH19 TNRC6C ZEB2 ANGPTL4 PRDM8 BHLHE22 TNRC6B CDH8 CTNNA1 CDH24 HOXC8 FOXF1 CTNND1 ADAM33 ADAM19 ILF3 MOV10 CDH11 ZC3H12A AGO4 SNAI1 CTNNB1 JUP AGO2 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling CDC37 HSP90AA1 ERBIN ERBB2 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs CASP7 CASP3 CASP9 APAF1 DIABLO-1 XIAP CYCS-1 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling JAK2 TYK2 EBI3 JAK1 IL6ST CANX CRLF1 STAT1 STAT3 IL27 IL27RA DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 MUC5B MUC20 MUC21 MUC3A GALNT12 MUC5AC MUC1 MUC2 MUC7 MUC4 MUC12 MUC6 MUC13 MUC17 MUC15 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions PIK3CB RAC1 VAV2 CD300E HRAS SYK PIK3CA LCK SIGLEC5;SIGLEC14 SOS1 KLRC4;KLRC3;KLRC2;KLRC1 TYROBP TREM1 PLCG1 FYN B2M HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KLRD1 CLEC5A PIK3R2 PIK3R1 GRAP2 BTK SIRPB1 PLCG2 KLRC4-KLRK1;KLRK1 VAV3 LCP2 TREM2 NRAS SIGLEC15 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding IZUMO4 ACR CD9 IZUMO1-1 IZUMO3 IZUMO2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose NUDT14 ALG5 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly APOC4 APOB MTTP APOC1 P4HB ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DERL3 DERL1 DERL2 OS9 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CFTR PSMD12 PSMD11 PSMD14 PSMD13 VCP-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ABCC9 ADRM1 SEL1L PSMA2-1 SEM1 ABCA1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 ABCG8 ABCG5 RNF185 ABCA3 KCNJ11 ABCC8 RNF5 ERLEC1 ABCA12 ABCD1 ABCC2 ABCB6 ABCB4 ABCD4 ABCC6 LMBRD1 ERLIN1 ERLIN2 ABCB11 APOA1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation MAP2K2;MAP2K1 MAPK1 RAPGEF1 MAPK3 BRAF FRS2 NGF YWHAB CRKL RAP1A RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription SMAD2;SMAD3 TP53 SMAD4 ZFHX3 RUNX3 CDKN1A TGFB1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint PSMD8 PSMD6 PLK3 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 GSK3B MAPK14 CSNK1A1 TPTEP2-CSNK1E;CSNK1E NEK11 MAPK11 CHEK1 CHEK2 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle ARHGEF26 PLD1 IQGAP2 ARHGAP21 YKT6 PAK4 ARHGAP39 MCF2 SRGAP3 LBR SRGAP2 SRGAP1 KTN1 VANGL1 PAK1 ARHGAP32 DIAPH3 PAK3 PAK2 WDR91 WDR81 CDC42SE2 ARHGAP9 ARHGAP4 WIPF1 GMIP WIPF2 CDC42EP5 WIPF3 CDC42EP4 CDC42EP3 CDC42EP2 KCTD3-1 CHN1 FARP1 DEF6 CAV1 SHKBP1 FAM13B VAV3 TAGAP PLEKHG4 PLEKHG1 ARFGAP2 BUB1B-PAK6;PAK6 VAV2 STEAP3 WASL SPATA13 SH3PXD2A RALBP1-1 WAS ARHGAP44 CDC42 DOCK11 ARHGAP45 ARHGAP22 ARHGAP20 ARHGAP29 PREX2 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 ARHGAP10 PAK5 DNMBP ARHGAP30 MYO9B DOCK6 DOCK9 ARAP1 FMNL1 DOCK7 FMNL2 IQGAP1 MAP3K11 LAMTOR1 TIAM1 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB CDC42BPB ARHGEF11 CDC42BPA TFRC ARHGEF10 ARHGEF12 FMNL3 STARD8 DAAM1 ARHGEF25 IQGAP3 STOM ECT2 STARD13 RASGRF2 JUP DLC1 PLEKHG2 ARHGEF15 ARHGEF19 ARHGEF4 ARHGEF7 NGEF ARHGEF6 FGD1 FGD2 FGD3 GNA13 FGD4 SNAP23 PARD6A DOCK10 SYDE1 ARHGAP42 GIT1 ARAP2 ARAP3 BCR TRIO ARHGAP17 ITSN1 PIK3R2 ABR ARHGAP1 ARHGDIG PIK3R1 RACGAP1 ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA MCF2L GIT2 BAIAP2 ARHGDIB ARHGAP26 TMPO PLEKHG3 ARHGEF16 ARFGAP3 DEPDC1B CDC42EP1 ARHGEF5 VAMP3 RAB7A TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer TGIF1-1 SP1 MAPK1 PPM1A NCOR1 E2F4-1 MAPK3 CDK9 NEDD4L PARP1 CCNT2-1 TRIM33 ATP1B4 CDKN2B USP9X SMAD2;SMAD3 SMAD4 CCNC-1 SMURF2 MYC MEN1 SKI SMAD7 UBA52 UBE2D1 HDAC1 COL1A2 YBX1 UBE2D3-1 SNW1 TGIF2 CCNK CCNT1 RBL1 WWTR1 RPS27A NCOR2 UBB;UBC SKIL SERPINE1 EP300 E2F5 FURIN JUNB TFDP1 RNF111 CDK8 TFDP2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis POMC HSD3B1;HSD3B2 HSD11B1 CYP21A2 HSD11B2 CYP11B1;CYP11B2 SERPINA6 CYP17A1 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI1 GLI2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein GCKR NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 GCK DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination TAB1 BARD1 RNF123 USP14 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 BRCC3 CLSPN NOD1 RCE1 BABAM1 IL33 NOD2 BABAM2 UIMC1 ABRAXAS1 SIAH2 TNIP2 USP18;USP41 TRAF3 H2BC5 H2AC16;H2AC11 UBE2D1 H2BC1 VCP-1 CDK1 H2AC4 CCP110 STAM HGS STAM2 H2BC21 GATA3 SMAD1 SMAD4 SMURF2 SMAD7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 EP300 ACTL6A TGFBR1-1 H2BC18 TGFBR2 DDB2 ARRB1 UCHL1 ARRB2 SENP8 UCHL3 HCFC1 TAF10 FOXK2 BECN1 FOXK1 MBD5 MBD6 ASXL1 ASXL2 USP9X IDE CFTR CDC25A AXIN2 APC YY1 TP53 KDM1B TADA3 FOXO4 TRRAP ATXN3 ACTB-1 RHOA DDX58 IFIH1 RNF135 USP34 MAVS TRIM25 TRAF2 PTEN UFD1 TOMM20 BIRC2 BIRC3 PRKN RIPK1 OGT-1 ADRB2 BAP1 WDR48 POLB USP30 TGFB1 RHOT1 JOSD2 SKP2 JOSD1 NLRP3 OTUD7B PTRH2 TNFAIP3 USP21 USP4 CYLD TOMM70 CDC20 SUDS3 ATXN7 SMAD2;SMAD3 USP33 SNX3 OTUD7A MDM2-2 USP13 STAMBPL1 TNKS TNKS2 RNF146 OTUD5 OTUD3 VCPIP1 MYSM1 OTUB1 MDM4 OTUB2 CCNA2-1 TNIP1 RNF128 USP15 CCNA1 TADA2B TNIP3-2 UCHL5 PSMD8 WDR20 PSMD6 USP8 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG MAP3K7 PSMC2-1 PSMA5 USP5 PSMA6 USP3 PSMA3 PSMA4 PSMA1 UBA52 FKBP8 STAMBP PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 VDAC2-1 PSMB2 VDAC3 PSMB3 PSMB1 RPS27A VDAC1 KAT2B UBB;UBC KAT2A ADRM1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 YOD1 PSMC3 PSMC4 PSMC1 RUVBL1 NFRKB ZRANB1 MUL1 ACTR5 RAD23A MAT2B ACTR8 RAD23B INO80C INO80B ESR1 INO80E INO80D AR TFPT MCRS1 USP37 INO80 USP47 USP48 USP49 USP42 H2AC14 USP44 MYC USP26;USP29 BRCA1 USP7 USP16 ABRAXAS2 USP2 USP24 USP25 USP20 USP22 USP28 HIF1A USP10 RIPK2 KEAP1 H2AC20 TRAF6 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events CALM3;CALM1 KPNA2 PDE1C PDE1B PDE1A GRK2 PRKCD PLA2G4A PRKCG AHCYL1 GNAT3 PRKACA-1 ADCY9 GNAL PRKAR1B PRKACB-1 NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A GNA14 ITPR1 GNA15 ITPR2 GNA11 ITPR3 CAMKK1 CAMKK2 MAPK1 CAMK2G PRKCA PLCB3 PLCB1 PLCB2 ADCY4 GNAI3 PRKAR2A GNAQ ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 PRKAR1A ADCY6 GNAI2 ADCY5 PLCB4 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) IDS FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct BMP4 PAX8 LHX1 ID4 HOXB4 GATA3 PCDH19 FGF2 WFDC2 MECOM CTNNB1 PLAC8 HOXA6 RET EMX2 OSR1 NPNT PAX2 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins RNF2 ZBED1 NUP43 RANBP2 SATB1 L3MBTL2 HDAC2 SUZ12 HDAC1 NUP37 SATB2 HDAC4 UBE2I PCGF2 NUP107 PIAS1 SUMO1 SUMO3 SUMO2 CBX5 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NDC1 NUP85 CHD3 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 CBX8 POM121;POM121C PHC2 NUP35 NUP54 PHC1 CBX4 CBX2 PHC3 SEC13 NUP133 BMI1 RING1 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events ADD2 PIP-1 LRRC8C LRRC8D LRRC8A LRRC8B RHCG RHBG LRRC8E NIPAL4 TUSC3 NIPAL1 NIPAL2 NIPAL3 AZGP1 RHAG ANKH NIPA1 MRS2 NIPA2 SLC66A1 ADD3 ADD1 DMTN CTNS MMGT1 MAGT1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy ATG14 TOMM40 ATG7 CSNK2A1;CSNK2A3 ATM TOMM7 OPTN-1 HDAC6 MAP1LC3A FUNDC1 USP30 ATG9A VCP-1 ATG12-1 PEX5 ATG5 NBR1 PLIN3 IFT88 MLST8 TOMM70 HSP90AA1 DYNC1LI1 HSP90AB1 PRKAA1 PRKAA2 DYNC1LI2 MTERF3 MTOR TSG101 MVB12B HBD;HBB MVB12A MTMR14 VPS37C VPS37D GABARAP VPS37A VPS37B UBAP1 VPS28 MFN1 MFN2 MTMR3 GABARAPL2 RPTOR TSC2 TSC1 DYNC1I2 RRAGA BECN1 MAP1LC3B2;MAP1LC3B-1 RRAGC RRAGB UVRAG RRAGD ULK1 DYNC1I1 SLC38A9 RHEB DYNC1H1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CETN1 PARK7 RNASE1 GFAP LAMP2 PLIN2 UBA52 CFTR PCNT EEF1A1 SQSTM1 UBE2D3-1 VDAC2-1 VDAC3 RPS27A VDAC1 HSF1 UBB;UBC HSPA8 WIPI1 PIK3R4 TBK1 PRKAB2 CSNK2A2 ARL13B PRKAB1 CSNK2B PIK3C3 CHMP4C CHMP4B EPAS1 CHMP3 TOMM20 CHMP4A TOMM22 CHMP6 CHMP7 PRKN ATG3 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C CHMP2B ATG4B CHMP2A ATG4A ATG4D PRKAG1 WDR45B PRKAG2 AMBRA1 UBE2V1 UBE2D3;UBE2D2 UBE2N PINK1 PRKAG3 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 MAPK1 HRAS MAPK3 BRAF FRS2 KLB PPP2R1A PIK3CA FGF1 FGF2 FGF4 FGF6 GAB1 FGF9 SOS1 FGF20 FRS3 FGF23 PLCG1 FGF16 FGF19 FGF18 UBA52 MKNK1 FGFR4 SPRY2 PTPN11 PIK3R1 PPP2CB;PPP2CA RPS27A UBB;UBC CBL NRAS CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TLR4 LY96 RIPK1 DAPK1-1 TRADD UNC5A CASP8 FADD UNC5B MAGED1 CASP3 DAPK2 CASP9 TNFSF10 TICAM2 DAPK3 TICAM1 APPL1 FAS FASLG CD14 TRAF2 DCC MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters SLC5A12 SLC17A5 SLC25A1 SLC5A8 SLC25A10 SLC25A11 GSD II%REACTOME%R-HSA-5357609.5 GSD II GAA GYG1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 MAFK PSMD8 NFE2L2 PSMD6 PSMD7 PSMD2 TKT PSMD3 PSMD1 CDKN2A BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF UBA52 BCL2 PDGFA AREG PSMD12 PSMD11 BCL2L1 PSMD14 PSMD13 CUL1 SQSTM1 RELA PSMA7 TXNRD1 PRDX1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A PGD UBB;UBC ADRM1 NOTCH1 NFKB1 RBX1 PSMA2-1 SEM1 PSMC5 ABCG2 PSMC6 PSMC3 PSMC4 PSMC1 GSK3B IDH1 ATF4 GSTA3;GSTA1 SP1 CCL13;CCL2 ABCF2-H2BE1;ABCF2 GCLC G6PD MAFG GCLM SRXN1 CHD6 ME1 ABCC3 PRKAA2 TALDO1 MYC NQO1 SOD3 TXN ABCC1 BACH1 KEAP1 SLC7A11 EP300 HMOX1 CREBBP REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling SOCS3 PTPN11 USP18;USP41 TYK2 JAK1 PTPN6 IFNAR1 PTPN1 IFNB1-4 SOCS1 STAT2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres LTBP1 MFAP5 ITGB8 MFAP4 ITGB6 TGFB3 MFAP3 ITGA8 MFAP2 VTN BMP2 ITGB1 GDF5 BMP10 BMP4 ITGB5 BMP7 TGFB2 EFEMP2 TGFB1 EFEMP1 ITGB3 FBLN1 FBLN2 FBLN5 LTBP4 ITGAV LTBP2 LTBP3 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis ALDH9A1 TMLHE SHMT1 BBOX1 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer PTEN INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling MAPK8 IL1RL2 IL1RAPL1 IL1F10 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway MAP2K2;MAP2K1 MAPK1 MAPK3 BRAF RAF1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination SNRPG-2 ZNF473 NCBP2-1 LSM10 SLBP LSM11 CPSF2-1 CPSF1 CSTF3 CPSF3 CSTF2 CSTF2T WDR33 NUDT21 PABPN1-1 CLP1 PCF11 PAPOLA SYMPK CPSF7 FIP1L1 CPSF4 SNRPD3 NCBP1 SNRPF SNRPB SNRPE-2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation FGF4 FGF6 FGF9 FGF20 FGF23 KLB FGF16 FGF19 FGF18 FGF1 FGFR4 FGF2 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription SIRT1 KLF9 FOXJ2 STRAP FOXP2 WT1 MPHOSPH8 H2AJ FOXQ1 TLE1 ZBTB33 HDAC2 PKM SUZ12 H2BC5 HDAC1 H2BC1 MCRIP1 SMARCA4 ZEB2 KLF4 H2AC4 KMT5A RB1 SNAI2 TCF12 TWIST2 SNAI1 KDM1A SP1 MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 CTBP2 CTBP1 ZNF217 H2AC14 TFAP2A RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 TGIF2 ARID1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FOXA2 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ZMYM2 ZEB1 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling SCD NCOR1 TBL1XR1 NR1H2 RXRA AGO3;AGO1 MYLIP APOE PCK1 KDM4A TNRC6A-1 TNRC6C ANGPTL3 HDAC3 ABCG1 CETP TNRC6B FABP6 NCOR2 MOV10 NRIP1 AGO4 FASN EP300 PLIN1 AGO2 ABCA1 RXRB APOC4 KDM3A GPS2 KDM1B NCOA1 NR1H3 APOD ABCG8 ABCG5 ARL4C EEPD1 APOC2 KDM1A APOC1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 NQO1 PSMA4 PSMA1 PSMD12 OAZ1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 ODC1 PSMB1 ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 AZIN1-2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) NGFR RHOA ARHGDIA LINGO1 MAG MCF2 OMG RTN4 DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system RBP1 OPN1SW TTR RLBP1 LRAT NAPEPLD OPN1MW3;OPN1MW2;OPN1MW;OPN1LW STRA6 RDH12 RBP4 ABCA4 RDH5 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism NADK2 PARP9 SLC22A13 PARP14 NMRK2 PARP8 PARP10 NMRK1 NAPRT CD38 NAXE RNLS NMNAT3 NMNAT2 NMNAT1 NAXD NT5E BST1 NADSYN1 NUDT12 SLC25A51;SLC25A52 SLC5A8 NADK NAMPT PARP6 NNMT QPRT PARP4 PARP16 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain F8 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle ARHGEF7 RHOU ITSN2 PAK4 ARHGEF6 USP9X WDR6 SRGAP2 PARD6A PAK1 VANGL1 CDC42 DST PTK2B PAK3 NCK2 PAK2 GIT1 MYO6 NCK1 SPTAN1 DLG5 TXNL1 PIK3R2 PIK3R1 WWP2 ARHGAP31 ARHGAP30 GIT2 SRC STAM PEAK1 HGS STAM2 DEPDC1B SPTBN1 IQGAP1 EPHA2 CLTC MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation ACOT9 ACOT7 MECR ECHS1 MCAT ACADVL ACSM3 HADH ACADS THEM5 HADHA HADHB-1 ACADL ACAD11 ACAD10 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 NDUFAB1 ACSF2 ACOT2;ACOT1 PCTP THEM4 MCEE PCCA MMAA PCCB ECI1 MMUT ACADM DECR1 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling NGFR CASP3 CASP2 YWHAE BEX3 NGF DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair POLD2 RBBP8 ATRIP BARD1 PPP4R2 XRCC2 TIPIN XRCC3 RPA1 TIMELESS BRCC3 RPA2 PPP4C PALB2 CLSPN SLX1A;SLX1B TP53BP1 POLE4 BABAM1 RAD50 BABAM2 H2AJ RAD51 UIMC1 RPA3 ABRAXAS1 POLE2 ALKBH3 RNF8 POLE3 RAD17 RNF168-1 FTO ALKBH5 ATM NSD2 RAD1 ASCC1 RAD52 RAD9B ASCC2 RAD9A ASCC3 ATR H2BC5 H2BC1 VCP-1 H2AC4 FAAP100 COPS5 PRKDC MDC1 XRCC6 XRCC5 FAAP24 LOC105377022;FANCB H2BC21 H2AZ2;H2AZ1 FANCM FANCL FANCD2 FANCA UBE2V2 FANCE FANCG FANCF GPS1 UBA7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 OGG1 NTHL1 TDG MBD4 SMUG1 NEIL3 COPS4 NEIL2 NEIL1 CETN2 COPS2 H2BC15;H2BC3;H2BC11;H2BC12 ELL ACTL6A DDB2 TCEA1 RNF4 CENPX RCHY1 YY1 RBX1 TP53 UVSSA ZNF830 ACTB-1 ERCC8 PARG ADPRS TRIM25 UFD1 PNKP PPIE DCLRE1B DCLRE1A FAN1 POLN NPLOC4 DCLRE1C RIF1 ALKBH2 LIG4 PAXIP1 KPNA2 NHEJ1 MGMT XRCC4 ISY1;ISY1-RAB43 SMARCA5 PPP5C TDP2 TDP1 BAP1 UBXN1 WDR48 USP1 XAB2 POLB POLL BAZ1B APEX1 UBE2B XRCC1 DDB1 APBB1 LIG3 KDM4A CUL4A DTL POLQ RAD18 EYA1 POLM CUL4B EYA2 EYA3 EYA4 ISG15 CDK2 AQR PRPF19 PARP1 KDM4B CENPS-CORT;CORT;CENPS TINF2 ACD UBE2T LIG1 CCNA2-1 RNF111 TERF2 CCNA1 POT1 TERF2IP MAPK8 SIRT6 TERF1-1 UBA52 MSH6 MSH2 MSH3 PMS2 MLH1 RPS27A UBB;UBC SEM1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RUVBL1 POLR2A NFRKB POLR2B PARP2 PIAS4 POLR2C ACTR5 POLR2D PIAS3 USP45 POLR2E UBE2I RAD23A POLR2F CHD1L POLR2G ACTR8 POLR2H ERCC5;BIVM-ERCC5 POLR2I RAD23B POLR2L ERCC6 INO80C GTF2H1 INO80B INO80E INO80D XPA GTF2H3 PIAS1 COPS7B COPS7A GTF2H4 XPC CDK7 POLR2J;POLR2J2;POLR2J3 TFPT MCRS1 SUMO1 ERCC3 INO80 SUMO3 ERCC2 COPS3 MNAT1 SUMO2 COPS6 ERCC4 H2AC14 ERCC1 COPS8 MPG MUS81 MRE11 BRCA1 USP7 BRCA2 KAT5 EME2 EXO1 CHEK1 POLK NBN TOPBP1 POLE POLH GEN1 CHEK2 RFC5 RMI2 RFC3 USP10 REV3L RFC4 PCLAF RFC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RMI1 POLI FEN1 USP43 RFC2 REV1 TOP3A HUS1 MAD2L2 ABL1 SPRTN SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 H2AC20 RTEL1 UBE2L6 BLM FANCI H2AB2;H2AB3;H2AB1 C1orf112 EME1-1 PCNA RAD51AP1 FANCC POLD3 POLD4 HERC2 WRN BRIP1 SLX4 FIGNL1 UBE2N POLD1 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD AHCY MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors CHRM4 CHRM5 CHRM2 CHRM3 CHRM1 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 TAB2 NCOR1 PSENEN PSEN2 PSEN1 APH1A EGFR NCSTN APH1B GFAP EGF UBA52 EREG APOE BTC HBEGF ADAM17 SRC NEDD4 RPS27A UBB;UBC GABRB3 GABRB2 GABRB1 STAT5A SPARC GABRG3;GABRG2 NRG1 WWOX NRAS WWP1 HRAS ESR1 DLG4 PIK3CA GABRQ CSN2-1 GABRA1 MXD4 CXCL12 PGR SOS1 STMN1 SHC1-1 ADAP1 YAP1-1 PIK3R1 NRG2 NRG3 ITCH NRG4 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA ACADL ECHS1 HADH HADHA HADHB-1 NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance COMT SLC6A3 BCHE LRTOMT SLC22A2 SLC22A1 ACHE ALDH2 MAOA SLC6A4 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes H2AJ NSD2 JMJD6 PAX3 SMARCD1 HDAC2 SMARCD2 PRMT7 PRMT3 SUZ12 H2BC5 H2AC16;H2AC11 HDAC8 COPRS KDM7A HDAC1 H2BC1 SMARCE1 MTA1 PRDM16 MTA3 HDAC10 H2AC4 KMT2A KMT2C RIOX2 NFKB2 PRMT6 PRMT1 DPY30 H2BC21 WDR5 EED H2AZ2;H2AZ1 MEAF6 RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 KDM5B ATF2 SMARCD3 HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 ARID1A ARID1B EP300 ACTL6B ACTL6A NCOA1 H2BC18 NCOA2 TAF9 CREBBP TAF12 JAK2 HCFC1 TAF10 NCOR1 TBL1XR1 CARM1 CLOCK MBD3 KDM4C-1 GATAD2B GATAD2A JADE1 JADE3 JADE2 ING4 ING3 VPS72 SUPT20H MSL2 MORF4L1-2 SUPT7L SUPT3H MSL1 TAF6L KAT6B MORF4L2 HAT1 ENY2 TAF5L BRD8 KMT5A DMAP1 KAT8 ELP1 ELP2 ELP3 ELP4 PADI2 MSL3-1 ELP5 ELP6 MRGBP MBIP TADA1 DR1 TADA2A KDM3A ZZZ3 KDM1B KMT2D YEATS2 TADA3 SGF29 KMT2B KANSL1 TRRAP KANSL2 KANSL3 ACTB-1 KDM5A BRPF1 KDM6A OGT-1 DNMT3A PADI3 PADI4 PADI1 PADI6 SMARCB1 EPC1 SMARCC1 SMARCC2 PHF2 KDM5C KDM2A KDM3B KDM2B KDM4D ARID5B PHF8 KDM4A SMARCA2 SMARCA4 RUVBL2 PBRM1 BRPF3-1 CCND1 ARID4A ARID4B KDM1A HMG20B CDK4 SAP30 BRMS1 PHF21A ARID2 SAP30L SAP18 KDM4B SUDS3 ATXN7 RCOR1 SMYD2-1 EHMT2 RPS2 EHMT1 CHD4 CHD3 EP400 MTA2 REST KDM6B PRDM7;PRDM9 TADA2B SAP130 SETD1B SETD1A ING5 RELA SUV39H2 SETD2 BRD1 SETD3 SETD6 NCOR2 SUV39H1 KAT2B KAT2A DOT1L SETD7 NFKB1 NSD3 MECOM PRMT5 NSD1 WDR77 KMT5B SMYD3 ATF7IP SETDB1 GPS2 KMT5C ASH1L AEBP2 RUVBL1 BRWD1 YEATS4 MCRS1 H2AC14 KAT5 KAT6A USP22 PHF20 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste KCNJ2 OTOP1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins LTA4H ALOX15 CYP1A2 CYP1A1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling PTPN6 PRKCA LYN YES1 LCK CBL SOS1 SH2B3 SH2B2 FYN SOCS1 KIT SOCS6 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway ATRIP RPA1 RPA2 SLX1A;SLX1B FANCM FANCL FANCA FANCD2 CENPX RPA3 FANCE FANCG FANCF ERCC4 ERCC1 CENPS-CORT;CORT;CENPS ATR MUS81 WDR48 EME2 UBA52 USP1 UBE2T RPS27A UBB;UBC FAAP100 FANCI EME1-1 FANCC DCLRE1B DCLRE1A FAN1 SLX4 POLN FAAP24 LOC105377022;FANCB CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition E2F4-1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CDC25A PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 RB1 PSMB3 PSMB1 CDKN1A RPS27A CDKN1B UBB;UBC ADRM1 PSMA2-1 CCND1 SEM1 E2F1 PSMC5 PSMC6 SKP2 PSMC3 PSMC4 PSMC1 TFDP1 CCNH TFDP2 MAX CCNE2 CDK4 CCNE1 CDK2 CDK7 MNAT1 AKT2 MYC RBBP4 AKT3 AKT1 PTK6 LIN54 CKS1B LIN52 RBL2 LIN37 LIN9 CABLES1 WEE1 E2F5 CCNA2-1 CCNA1 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria AUH DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD OPLAH SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus IPPK IP6K2 IP6K1 IPMK DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CEL LIPF CLPS PNLIP PNLIPRP1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids GPX1 ALOX5 PON3 PON2 PON1 LTC4S ALOX5AP GPX4 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation CRP C1QB C1S C1R C1QC DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species PRDX3 PRDX6 NOX5 NCF1 NCF2 GPX1 NCF4 GPX6 GPX5 GPX8 GPX7 GSTP1 TXNRD2 SOD2 SOD3 CYBB ATOX1 SOD1 CYBA CCS PRDX2 TXN TXNRD1 PRDX1 ATP7A CAT CYCS-1 TXN2 NOX4 ERO1A AQP8 NUDT2 P4HB G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase JAK2 PPP2R2A;PPP2R2D E2F4-1 PPP2R1B CDKN2D PPP2R1A CDKN2B CDKN2C CDKN2A CDK7 SKP1 MNAT1 UBA52 CUL1 PTK6 CKS1B RBL2 LYN RBL1 RB1 PPP2CB;PPP2CA CDKN1C ABL1 CDKN1A RPS27A CDKN1B UBB;UBC CCND3 CCND2 CCND1 E2F1 E2F2 E2F5 E2F3 SKP2 PPP2R3B TFDP1 CCNH CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network RAC1 VAV1 IL33 PDGFRB TRAT1 NTRK3 PIK3AP1 IL1RL1 TGFA KIT FLT3LG CD86 CD80 SRC INSR THEM4 MET INS;INS-IGF2 FLT3 PIK3CD PIK3CB MAPK1 PIK3CG PDGFB CD19 MAPK3 FRS2 PPP2R1B PPP2R1A PIK3CA IER3 LCK PHLPP2 PHLPP1 IRAK1 PIP5K1C STRN ESR2 FYN PTPN11 PPP2CB;PPP2CA PPP2R5E ERBB2 NRG2 PPP2R5B NRG3 PPP2R5A NRG4 PPP2R5D PIP4K2A PPP2R5C PIP4K2B PIP5K1A PIP5K1B EGFR NTRK2 BDNF GAB1 NTF4 NTF3 EGF EREG AREG BTC EPGN HBEGF NRG1 HGF ESR1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 FGF20 FGF23 AKT3 FGF22 AKT1 GAB2 FGF16 FGF19 FGF18 PTEN TRIB3 FGFR4 FGF10 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 MYD88 RHOG CD28 TRAF6 PDGFRA IRAK4 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains PTPRJ CD4 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PAG1 LCK HLA-DQB2;HLA-DQB1 PTPN22 HLA-DPB1-1 HLA-DRA CD3G PTPRC CSK CD3E CD3D SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CB HRAS PIK3R2 SOS1 PIK3R1 PIK3CA STAT1 PDGFRA STAT3 NRAS ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia ARG1 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes ELANE HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation ABCC2 GSTA3;GSTA1 HMOX2 HMOX1 BLVRB ABCG2 ABCC1 BLVRA FABP1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ALB UGT1A1;UGT1A6 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD17B1 AKR1B15;AKR1B10 STS FDX1 FDXR SRD5A3 HSD3B1;HSD3B2 CYP21A2 STARD3 CYP11B1;CYP11B2 STARD4 STARD6 STARD3NL STAR TSPO POMC CYP11A1 HSD17B3 HSD17B12 SRD5A2 SRD5A1 CYP17A1 AKR1B1 CGA HSD17B11 HSD17B2 TSPOAP1 HSD11B1 HSD11B2 SERPINA6 LHB CYP19A1 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste GNB1 GNB3 SCN2A SCN2B TAS2R39 TAS1R2 TAS1R1 PLCB2 TAS1R3 SCN9A SCN1B GRM1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GNAT3 PRH1-TAS2R14;TAS2R14-3 CALHM1 SCN4B TAS2R7 TAS2R8 TRPM5 CALHM3 TAS2R3-1 TRPM4 GRM4 SCN3A TAS2R16 TAS2R40 GNG13 TAS2R41 TAS2R1 TAS2R4 ITPR3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer NCOR1 PSENEN TBL1XR1 PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL SKP1 HDAC5 HDAC2 UBA52 HDAC8 HDAC9 HDAC6 HDAC1 HDAC7 MIB2 CUL1 SNW1 JAG2 JAG1 ADAM10 HDAC10 DLL1 HDAC11 MIB1 DLL4 NEURL1B ADAM17 NCOR2 RPS27A NEURL1 KAT2B UBB;UBC KAT2A NOTCH1 RBX1 RBPJ HDAC4 MAMLD1 CCNC-1 MYC HDAC3 HEY1 MAML2 HEY2 HES1 MAML1 EP300 CDK8 CREBBP DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER POLD2 RPA1 RPA2 TCEA1 POLE4 RPA3 POLE2 POLE3 ISY1;ISY1-RAB43 UBA52 XAB2 DDB1 CUL4A CUL4B RPS27A UBB;UBC RBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2A POLR2B POLR2C POLR2D UVSSA AQR ZNF830 POLR2E POLR2F POLR2G PRPF19 POLR2H ERCC5;BIVM-ERCC5 POLR2I POLR2L ERCC6 GTF2H1 XPA GTF2H3 GTF2H4 ERCC8 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 ERCC4 ERCC1 USP7 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 PPIE PCNA POLD3 POLD4 POLD1 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction NANOS3 NANOG;NANOGP8 RBBP8 CBFA2T2 POU5F1;POU5F1B RPA1 RPA2 RAD50 H2AJ RAD51 RPA3 ATM ATR H2BC5 H2BC1 PDPN H2AC4 SPO11 PSMC3IP MND1 MLH3 MSH4 DMC1 MSH5 CDK4 CDK2 PRDM1 H2BC21 SMC3 H2AZ2;H2AZ1 HSPA2 EOMES TFAP2C SOX17 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TINF2 RAD21 CXCR4 H2BC15;H2BC3;H2BC11;H2BC12 STAG1 STAG2 ACD TET2 SMC1A PRDM7;PRDM9 TERF2 POT1 TERF2IP CATSPER1 CATSPER3 CATSPER2 CATSPER4 HVCN1 SYCP1 ADAM21 SYNE2 ADAM20 ZP3;POMZP3 SYNE1 IZUMO3 SUN1 SPAM1 OVGP1 TEX12 IZUMO2 SMC1B TERF1-1 IZUMO4 SYCP3-2 SYCE2 ADAM30 SYCE1 ACR ADAM2 FKBP6 REC8 STAG3 KCNU1 SYCP2-1 CATSPERB CATSPERD CATSPERG CD9 ZP1 IZUMO1-1 ZP2 ZP4 LMNB1 MLH1 UBE2I B4GALT1 H2AC14 MRE11 BRCA1 BRCA2 NBN BMP4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TOP3A RAD51C H2AC20 SUN2 BLM H2AB2;H2AB3;H2AB1 C1orf112 FIGNL1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CDKN2A SMURF2 PSMC2-1 SMURF1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MDM2-2 CBFB PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 SRC PSMB1 RUNX3 RPS27A TGFB1 UBB;UBC ADRM1 PSMA2-1 EP300 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 NTRK1 NGF STAT3 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 UBA52 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPS27A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 RPS3A RPL13A-1 RPL11 RPS27L RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 SEPHS2 SECISBP2 EEFSEC SEPSECS PSTK RPS27 SARS1 RPL4 RPL30 RPL3 RPL32 RPL31 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A2 SLC39A10 SLC39A1 SLC39A3 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A4 SLC39A7 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants MAP2K2;MAP2K1 MAPK1 FGB HRAS FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B VCL FN1 CSK MARK3 SRC ITGB3 ARAF PEBP1 ARRB1 YWHAB IQGAP1 ARRB2 NRAS RAP1B RAP1A ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport LMAN1 STX5 YKT6 TGFA ARF4-1 CSNK1D INS;INS-IGF2 ARFGAP2 MCFD2 SERPINA1 PPP6C TFG PPP6R1 ARF5 PPP6R3 CTSC TMED2-1 ARCN1 TRAPPC2L TRAPPC2;TRAPPC2B LMAN1L F5 TRAPPC6A DYNC1LI1 F8 TBC1D20 TRAPPC6B DYNC1LI2 GORASP1 PREB SEC22B SEC22A SEC22C KDELR2 RAB1A TMED10 STX17 LMAN2L RAB1B SPTAN1 GOSR2 USO1 SCFD1 CAPZB LMAN2 CD59 ANK2 SEC31B MIA2 ANK3 SEC31A ANK1 ANKRD28 TRAPPC3 SPTB TRAPPC1 TRAPPC4 TRAPPC10 TRAPPC5 CAPZA1 TRAPPC9 ARFGAP1 CAPZA2 ACTR1A SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 SEC13 SPTBN4 SPTBN5 SPTA1 GOSR1 SPTBN1 SPTBN2 DYNC1I2 COPZ2 COPZ1 DYNC1I1 DYNC1H1 DCTN2 DCTN3 AREG GOLGA2 NSF GRIA1 BET1L GBF1 ARF1 CTSZ MIA3 SEC23A SAR1B GOLGB1 SEC24B SEC24A SEC24D-1 TMED3 TMED7 TMED9 SEC24C COPG2 COPG1 COPB2 COPA NAPA KDELR3 COPB1 NAPB DCTN1 TMEM115 COPE KDELR1 NAPG DCTN6 DCTN5 COG8 DCTN4 COG7 CD55 COG6 CAPZA3 COG5 ACTR10 COG4 COG3 COG2 COG1 ARFGAP3 COL7A1 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors TBXA2R PTGFR PTGDR PTGER4 PTGDR2 PTGER2 PTGER3 PTGIR PTGER1 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine COMT SLC6A3 LRTOMT MAOA ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 H2AJ PSMD1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 H2BC5 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 H2BC1 CDC23 PSMD13 UBE2S CDC26 CDC16 CDC27 PSMA7 ANAPC4 PSMB6 ANAPC5 PSMB7 ANAPC1 PSMB4 H2AC4 KPNB1 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 FZR1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 H2BC21 H2AZ2;H2AZ1 CDC6 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KPNA1 H2BC15;H2BC3;H2BC11;H2BC12 GMNN KPNA6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDT1 MCM7 ORC5 ORC4 ORC6 MCM3 ORC1 MCM8 MCM4 MCM5 ORC3 H2AC20 MCM6 ORC2 MCM2 H2AB2;H2AB3;H2AB1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation PTPN11 DUSP6 MAP2K2;MAP2K1 JAK2 DUSP7 MAPK1 TYK2 JAK1 MAPK3 CDK1 DUSP16 DUSP10 DUSP5 IL6R DUSP2 DUSP1 DUSP8 DUSP9 IL6 PEA15 DUSP4 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors HCAR2;HCAR3 HCAR1 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling ALK PTN MDK PTPRZ1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression MED9 CDK19 FADS1 G0S2 FHL2 TNFRSF21 MED28-1 CPT1A ANKRD1 APOA2 GRHL1 APOA5 ANGPTL4 TXNRD1 CPT2 FABP1 ABCA1 RXRB NR1H3 MED31-1 ARNT2 NCOA3 NRF1 THRAP3 FAM120B CCNC-1 RGL1 PPARGC1B SMARCD3 HDAC3 CHD9 MED16 MED15 SULT2A1-4 MED17 NPAS2 MED12 MED14 ARNTL HELZ2 MED13 MED10 TGS1 EP300 PPARGC1A NCOA1 MED27 MED1 MED26 NCOA2 CREBBP ACADM MED23 MED8 NCOA6 MED25 MED4 APOA1 MED6 NR1D1 MED24 MED7 MED20 NCOR1 TBL1XR1 CARM1 CLOCK AHR PLIN2 CYP1A1 AHRR HMGCS1-1 CD36 SREBF2 MTF1 NCOR2 ACSL1 PEX11A FDFT1 GPS2 MED19 NFYB MED18 NFYC MED11 MED29 MED22 SP1 MED21 MED30 NFYA-1 NR1H2 RORA TIAM2 NR1H4 AGT CYP7A1 ME1 RXRA PPARG ALAS1 PPARA MED13L HMGCS2 TRIB3 ABCB4 GLIPR1 ARNT ESRRA SLC27A1 CDK8 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm NXF2;NXF2B;NXF5-1 THOC1 THOC3 THOC2 THOC5 CDC40 NCBP2-1 THOC7 THOC6 NUP43 SRRM1 SLBP DDX39A DDX39B SARNP ZC3H11A EIF4E SRSF2 SRSF3 RANBP2 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A POLDIP3 SRSF1 NXF1 U2AF2 FYTTD1-1 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NUP37 CPSF4 NUP107 CPSF2-1 CPSF1 CPSF3 NUP205 NUP188 WDR33 AAAS NUP42 NUP62 NUP160 TPR SYMPK NUP88 RAE1 NDC1 FIP1L1 NUP85 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 NCBP1 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 GLE1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC19A3 SLC19A2 SLC25A19 THTPA TPK1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism ASAH1 NEU2 SMPD3 NEU3 SMPD2 GBA2 NEU1 STS ENPP7 ARSA GM2A CTSA GLA SUMF2 SUMF1 HEXB HEXA ARSL GLB1L3 SMPD4 ARSJ GLB1L2 ARSK ARSH ARSI GLB1L GLB1 ARSG SMPD1 ASAH2 PSAP ARSB ARSD-1 GALC M6PR GBA DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b MPI THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex PER2 PER1 CRY2 CRY1 CSNK1D CLOCK NPAS2 TPTEP2-CSNK1E;CSNK1E ARNTL CREBBP KMT2A BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA ECHS1 HADH ACADM HADHA HADHB-1 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway CGA FUT8 MAN2A1 CHST8 MAN2A2 MGAT2 CHST10 FUT6;FUT5;FUT3 FUCA1 LHB SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA ERBIN ERBB2 GAB1 SOS1 SHC1-1 PLCG1 EGF NRAS RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking CFTR GOPC DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a MGAT2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism PGAM2 PGM2L1 PFKL NUP43 PC GNPDA1 ALDOC ALDOB PGK1 GNPDA2 PFKM ALDOA PFKP RANBP2 GPI PCK1 NUP37 PRKACA-1 PRKACB-1 GAPDHS PFKFB2 PFKFB1 PFKFB4 PFKFB3 GCK GCKR SLC37A1 NUP107 ENO1 G6PC2 ENO2 G6PC3 ENO3 PPP2R1B ENO4 PPP2R1A G6PC1 ADPGK HK2 NUP205 NUP188 HK1 HK3 AAAS GAPDH-1 NUP42 NUP62 NUP160 TPR NUP88 SLC37A4 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 BPGM NUP153 NUP93 HKDC1 NUP50 POM121;POM121C PCK2 NUP35 NUP54 PPP2CB;PPP2CA FBP1 FBP2 SEC13 NUP133 PPP2R5D TPI1 PGAM1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO1 NTN1 ROBO2 SLIT1 SLIT3 NELL2 DCC SRC SLIT2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants FLT3 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses STING1 NMI TOMM70 PPIA IRAK2 TBK1 IRF3 CASP1 KPNA2 FKBP1A DDX58 IFIH1 PCBP2 SIKE1 TRAF3 RIPK3 MAVS TRIM25 IKBKE BST2 UBA52 TLR7 SFTPD RELA RUNX1 PYCARD RCAN3 KPNB1 PPIH RPS27A PPIG UBB;UBC PPIB NFKB1 NFKBIA ITCH TRAF6 NLRP3 TKFC HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CUL3 PSMC2-1 SPOP PSMA5 GRK2 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 GLI3 PSMD13 GLI2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 IHH EVC2 PSMC4 EFCAB7 PSMC1 EVC GAS8 SHH CDC73 KIF3A CSNK1A1 SMO HHIP BOC GAS1 CDON GLI1 KIF7 GPR161 DHH SMURF2 SMURF1 ULK3 DZIP1 SPOPL NUMB PTCH1 ITCH ARRB1 ARRB2 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis GNB1 KCNMB2 GNB4 KCNMB3 PAFAH2 GNB3 GNB5 KCNMB4 CALM3;CALM1 PDE1B PDE1A PLA2G4A ATP2A3 ATP2A2 ATP2A1 GUCY1B1 SLC8A1 SLC8A2 LRP8 NOS2 NOS1 STIM1 ORAI2 ORAI1 TRPC7 GUCY1A2 GUCY1A1 P2RX6 TRPC6 ITPR1 P2RX5 GNGT1 TRPC3 ITPR2 P2RX3 P2RX2 P2RX1 PTGIR ITPR3 SRI PRKG2 ATP2B4 GNAS-1 ATP2B3 PPP2R1B FGR MAPK14 PPP2R1A ATP2B2 ATP2B1 SLC8A3 PDE2A GNG10 P2RX7 PDE11A P2RX4 GNG2 GNG5 PTPN11 PDE10A GNG4 GNG8 PDE5A PTPN6 KCNMB1 KCNMA1 PPP2CB;PPP2CA IRAG1 NOS3 PDE9A PPP2R5E PPP2R5B PPP2R5A APOB PPP2R5D PECAM1 PPP2R5C GNG13 GNB2 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance LDLR LIPC APOB LDLRAP1 APOE TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation MED7 MED20 MED9 CEBPB NCOR1 TBL1XR1 CARM1 CDK19 MED28-1 PCK1 CD36 RELA ANGPTL4 KLF4 SREBF2 TNF LPL FABP4 NCOR2 TGFB1 CCND3 NFKB1 PLIN1 CEBPD MED19 MED18 MED11 CDK4 MED29 MED22 MED31-1 MED21 MED30 EBF1 NCOA3 EGR2 ADIRF THRAP3 ZNF638 FAM120B ZNF467 LEP RXRA PPARG CCNC-1 PPARA MED13L SMARCD3 WNT1 HDAC3 CHD9 MED16 MED15 MED17 CEBPA WNT10B MED12 MED14 SLC2A4 MED13 HELZ2 MED10 KLF5 TGS1 EP300 ADIPOQ PPARGC1A NCOA1 MED27 MED1 MED26 NCOA2 CDK8 NR2F2 MED23 CREBBP NCOA6 MED8 MED25 MED4 MED6 MED24 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 GNAS-1 GNG13 GNGT1 GNG10 GNB2 PTGIR GNG2 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) SNAP25 STX1A DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency CYP11B1;CYP11B2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway POLD2 PARP1 RPA1 RPA2 POLE4 PARG RPA3 POLE2 ADPRS POLE3 POLB APEX1 POLE RFC5 RFC3 RFC4 RFC1 FEN1 RFC2 LIG1 PCNA POLD3 POLD4 PARP2 POLD1 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs MOV10 CDH1 AGO4 TNRC6C AGO2 MYC TNRC6B MYCN TNRC6A-1 AGO3;AGO1 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization H2AJ NSD2 JMJD6 PAX3 SMARCD1 HDAC2 SMARCD2 PRMT7 PRMT3 SUZ12 H2BC5 H2AC16;H2AC11 HDAC8 COPRS KDM7A HDAC1 H2BC1 SMARCE1 MTA1 PRDM16 MTA3 HDAC10 H2AC4 KMT2A KMT2C RIOX2 CTNNB1 NFKB2 PRMT6 PRMT1 DPY30 H2BC21 WDR5 EED H2AZ2;H2AZ1 MEAF6 BCL11A RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 KDM5B ATF2 CBX3-1 SMARCD3 HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 CHD9 ARID1A ARID1B NR2C2 ZNF592 CHD5 IKZF1 EP300 IKZF2 IKZF3 SUPT16H PHF6 ZMYND8-1 ACTL6B ZNF827 ACTL6A NCOA1 ZNF687 TCF19 H2BC18 NCOA2 MBD2 TAF9 NR2F2 CREBBP CDK2AP2 CDK2AP1 ZNF532 TAF12 JAK2 HCFC1 TAF10 NCOR1 TBL1XR1 SSRP1 CARM1 MAFK CLOCK NFE2L2 ADNP2 ADNP MBD3 KDM4C-1 GATAD2B GATAD2A JADE1 JADE3 JADE2 ING4 ING3 VPS72 SUPT20H MSL2 AXIN2 MORF4L1-2 IGF2 SUPT7L SUPT3H MSL1 TAF6L PHF10 BCL11B KAT6B MORF4L2 HAT1 ENY2 TAF5L BRD8 KMT5A DMAP1 KAT8 ELP1 ELP2 ELP3 ELP4 PADI2 MSL3-1 ELP5 ELP6 MRGBP MBIP TADA1 DR1 TADA2A KDM3A ZZZ3 KDM1B KMT2D YEATS2 TADA3 SGF29 KMT2B KANSL1 TRRAP KANSL2 KANSL3 ACTB-1 KDM5A DKK2 BRPF1 G6PC1 KDM6A CHD8 DHX15 BICRAL BICRA OGT-1 BRD9 DDX46 DDX42 RBM17 DNMT3A SMNDC1 U2SURP PADI3 PADI4 PADI1 PADI6 SMARCB1 EPC1 SMARCC1 SMARCC2 SF3B4 SF3B5 PHF2 SF3B2 SF3B3 KDM5C KDM2A SF3B6 KDM3B SF3B1 KDM2B SF3A3 KDM4D ARID5B PHF8 SF3A1 SF3A2 PHF5A PCK1 KDM4A SMARCA2 SMARCA4 SNRPN RUVBL2 CHERP PBRM1 BRPF3-1 SNRPA1 CCND1 PUF60 SNRPB2 ARID4A ARID4B KDM1A HMG20B CDK4 CHD1 SAP30 BRMS1 PHF21A ARID2 SAP30L SAP18 KDM4B SUDS3 ATXN7 RCOR1 SMYD2-1 EHMT2 RPS2 EHMT1 CTCF CBX1 CHD4 CHD3 EP400 MTA2 CHD7 NKD2 REST FAM124B KDM6B PRDM7;PRDM9 CHD2 TADA2B SAP130 SETD1B SETD1A ING5 RELA SUV39H2 SETD2 BRD1 SETD3 TCF12 SETD6 NCOR2 SUV39H1 KAT2B KAT2A DOT1L SNRPD2 SETD7 NFKB1 SNRPD1 NSD3 SNRPD3 MECOM PRMT5 NSD1 WDR77 KMT5B SMYD3 ATF7IP SETDB1 GPS2 BRD7 KMT5C ASH1L AEBP2 SNRPF RUVBL1 SNRPB SNRPE-2 SNRPG-2 CTR9 UBE2I PWWP2B WDR61 MBD3L1 RTF1 PWWP2A CDC73 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 LEO1 BRWD1 CHD6 YEATS4 MCRS1 SUMO1 H2AC14 PAF1 NQO1 KAT5 KAT6A USP22 PHF20 MYOG MYOD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TCF4 FBP1 BCL7A BCL7C DPF1 H2AC20 BCL7B DPF2 DPF3 H2AB2;H2AB3;H2AB1 SS18 SS18L1 EZH2 ASH2L DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse MYH10 MYL6 NGEF LYN YES1 ROCK1 ROCK2 RHOA MYL12B MYH11 MYH9 FYN MYH14 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC1 APOBEC2 A1CF RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 NPLOC4 RPL18A RPL37A-1 RPL35 RPL38 RPL39 RPL15-1 UBE2D1 RPL21 RPL23 RPL22 VCP-1 RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL3L RPL5-1 RPL27A LTN1 RPL36AL-1 RPLP1-2 RPLP0 RPL7A RPLP2 RPL36-1 CUL2 RPL13A-1 RPL11 RPL14 RPL13 RPL12-1 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 RPL26L1 ANKZF1 KLHDC10 TCF25 NEMF ELOC-1 ELOB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RCHY1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UFD1 RPL4 RPL30 RPL3 RPL32 UBE2D3;UBE2D2 RPL31 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription SRF KCNIP3 NR3C1 REST CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly AKAP9-1 PLK1 HDAC6 CDK1 DYNC2I2 NEK2 DYNC2I1 TRAF3IP1 IFT172 CCP110 PRKACA-1 ARF4-1 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CSNK1D IFT80 PRKAR2B CYS1 RPGRIP1L LZTFL1 IFT88 IFT81 TTC30A;TTC30B UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B HSP90AA1 NPHP1 YWHAG CEP70 NPHP3 CEP72 PPP2R1A CEP192 KIF3C MARK4 RAB11FIP3 CEP76 CEP78 BBS2 PLK4 BBS1 ODF2 RAB3IP IFT122 BBIP1 IFT20 AHI1 IFT22 MKS1 CEP83 IFT27 DYNLRB2 DYNLRB1 CEP89 CEP57 TTC26 C2CD3 CETN2 CEP164 PKD2 PKD1 HSPB11 IFT52 ACTR1A TCTN3 TCTN2 MAPRE1-1 CNTRL TCTN1 BBS9 CNGA2 BBS7 CNGA4 IFT57 TNPO1 BBS5 CC2D2A CEP290 BBS4 RAB8A DYNLT5 IQCB1 CKAP5 MKKS EXOC8 DYNLT2 IFT140 EXOC7 HAUS4 KIF24 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 CLASP1 BBS12 RP2 TMEM216 EXOC4 DYNC1H1 EXOC3 EXOC6 NDE1 CEP63 EXOC5 YWHAE IFT46 EXOC2 EXOC1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 DYNLT2B B9D2 ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT CCT3 OFD1-1 CCT2 SEPTIN2 CEP152 GBF1 WDR19 SCLT1 RAB11A ATAT1 NEDD1 TTC8 TUBA4A ALMS1 CEP162 TCP1 TRIP11 B9D1 CEP41 CLUAP1 CEP43 KIF17 CCT8 CCT5 CCT4 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 SMO TPTEP2-CSNK1E;CSNK1E ARL13B INPP5E PDE6D RHO CNGB1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 C12orf65 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MIEF1 MRPS22 MALSU1 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MTRES1 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS36 MRPS33 MRPL18 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 LOC107987373;MRPL23 MRPL30 NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 PLCG1 NGF TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions SEMA3A RAC1 SEMA3E SEMA4A FARP2 TLN1 RND1 CD72 PLXNA1 PAK1 TYROBP PAK3 PAK2 FES SEMA4D LIMK2 LIMK1 RRAS CRMP1 MYH14 ARHGEF11 MYH10 ARHGEF12 CDK5 RHOB CDK5R1 PLXND1 MYL12B MET MYH11 MYH9 GSK3B HSP90AA1 RHOC MYL6 SEMA5A HSP90AB1 ROCK1 ROCK2 RHOA NRP1 DPYSL2 PLXNB1 PIP5K1C FYN ITGB1 CFL1 ITGA1 ARHGAP35 DPYSL4 DPYSL5 DPYSL3 ERBB2 PLXNA4 PLXNC1 SEMA6A SEMA6D SEMA7A PLXNA2 PLXNA3 PTPRC PLXNB3 TREM2 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 CYP4F22 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling GPIHBP1 APOB APOC3 LPL APOC2 APOA2 APOA4 APOE APOA1 APOA5 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle SLC6A12 ABAT ARL6IP5 UNC13B GAD1 SNAP25 GAD2 SLC6A13 GLS2 SLC6A11 SYT1 SLC22A2 SLC22A1 STX1A SLC6A1 VAMP2 SLC18A2 SLC18A3 CASK SLC32A1 SYN3 SYN2 LIN7A SYN1 LIN7C ALDH5A1 LIN7B SLC17A7 RAB3A RIMS1 SLC5A7 PPFIA1 PPFIA4 PPFIA3 PPFIA2 HSPA8 NAAA CHAT CPLX1 DNAJC5 TSPOAP1 MAOA APBA1 SLC1A1 SLC1A2 SLC1A3 GLS SLC1A6 SLC1A7 SLC38A2 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation NMT1 WASL HSP90AA1 SPR NOS3 CAV1 NMT2 CALM3;CALM1 ZDHHC21 DNM2 NOSTRIN AKT1 NOSIP DDAH1 LYPLA1-1 CYGB SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion FFAR1 PLCB3 GNA14 PLCB1 PLCB2 GNA15 GNA11 GNAQ APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PSMD8 BUB3 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 ANAPC15 PSMA6 ANAPC16 ANAPC7 PSMA3 PSMA4 UBE2C PSMA1 UBE2E1 UBA52 UBE2D1 PSMD12 ANAPC10 PSMD11 ANAPC11 PSMD14 CDC23 PSMD13 MAD2L1 UBE2S CDC26 CDC16 CDC27 PSMA7 CDK1 ANAPC4 PSMB6 ANAPC5 PSMB7 NEK2 ANAPC1 PSMB4 ANAPC2 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 BUB1B CDC20 CCNA2-1 CCNA1 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 M PHASE%REACTOME%R-HSA-68886.5 M Phase H2AJ CSNK2A1;CSNK2A3 LBR AKAP9-1 ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 H2BC5 UBE2E1 UBE2D1 ANAPC10 ANAPC11 H2BC1 CCNB1 CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 NEK2 ANAPC1 H2AC4 ANAPC2 CCP110 CEP250 CDK5RAP2 SET-1 CEP135 CSNK1D MAPK1 H2BC21 YWHAG PRKCA CEP70 CEP72 H2AZ2;H2AZ1 CEP192 CEP76 CEP78 EML4 PLK4 GORASP1 ODF2 RAB1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RAB1B USO1 CEP57 CETN2 CEP164 H2BC15;H2BC3;H2BC11;H2BC12 SPAST CC2D1B VPS4A SIRT2 IST1 ACTR1A VRK1 LEMD2 ESPL1 CNTRL XPO1 TNPO1 CEP290 HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 PTTG1;PTTG2 YWHAE TUBA1C TUBA1A DCTN2 SSNA1 CENPJ TUBB1 DCTN3 LMNB1 HAUS8 HAUS7 GOLGA2 RCC1 PCNT OFD1-1 CEP152 TUBB2B;TUBB2A NEDD1 KMT5A ALMS1 TUBA4A CEP41 CEP43 ARPP19 NCAPH2 TUBB3;TUBB6 NCAPG2 SMC4 NIPBL TUBAL3 SMC2 ENSA NCAPD3 TUBGCP2 RAB2A MZT2A;MZT2B NCAPG CTDNEP1 BLZF1 NCAPH CNEP1R1 TUBGCP5 MAU2 TUBGCP6 TUBA3E;TUBA3C-1 TUBGCP3 MASTL TUBGCP4 GORASP2 NUMA1 MCPH1 TUBG2 NME7 MZT1 NCAPD2 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E TUBA8 NUP205 NUP188 AAAS NUP42 NUP62 TPR BANF1 NUP88 RAE1 CHMP4C NDC1 CHMP4B ANKLE2 NUP214 CHMP3 NUP210 CHMP4A NUP155 NUP153 CHMP6 NUP93 CHMP7 NUP50 POM121;POM121C NUP35 NUP54 EMD KIF20A LEMD3 CHMP2B CHMP2A KIF23 KPNB1 RB1 PRKACA-1 FBXO5 LPIN1 LPIN2 PRKAR2B LPIN3 PPP2R2A;PPP2R2D ERCC6L NUP107 ZWILCH BUB1B SMC3 HSP90AA1 PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 RAN SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 NEK9 CENPA NEK6 NEK7 AURKB NSL1 CENPC PSMD8 NUP43 BUB3 PSMD6 BUB1 PSMD7 DYNC1I1 PSMD2 CLASP1 PSMD3 CLASP2 PSMD1 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE PRKCB CENPF CENPH PSMC2-1 CENPI PSMA5 TAOK1 PSMA6 CENPK PSMA3 CENPL PSMA4 CENPM PSMA1 B9D2 UBA52 CENPO CENPP CENPQ PSMD12 SPC24 PSMD11 SPC25 PSMD14 MAD2L1 PSMD13 NUP37 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UBE2I SUMO1 H2AC14 CSNK2A2 CSNK2B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 H2AB2;H2AB3;H2AB1 C1orf112 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 DCP1A RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 PPP2R2A;PPP2R2D RPS4X RPL7A RPLP2 RPL36-1 RPS3A GSPT2 PPP2R1A GSPT1 RPL13A-1 RPL11 RPS27L RPS15A RPL14 PABPC1;PABPC3 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 UPF2 FAU RPL26L1 ETF1 RPS27 PPP2CB;PPP2CA NCBP1 UPF1 EIF4A3 CASC3 SMG1 SMG9 NCBP2-1 SMG7 SMG8 SMG5 SMG6 RBM8A EIF4G1 UBA52 MAGOH;MAGOHB UPF3B RNPS1 RPS27A RPL4 RPL30 RPL3 RPL32 RPL31 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJB3 GJB6 GJB5 GJB7 GJD4 GJD3 GJB1 GJA1 GJB2 GJD2 GJC1 GJA10 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs AGO4 TNRC6C AGO2 TNRC6B TNRC6A-1 AGO3;AGO1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus CNTN1 NOTCH2 PSENEN PSEN2 JAG2 PSEN1 JAG1 APH1A ADAM10 NCSTN DLL1 APH1B MDK MIB1 DLL4 NEURL1B NEURL1 RPS27A UBB;UBC UBA52 MIB2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade FRAT2 AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 LBP CD14 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ERCC6L NUP107 ZWILCH BUB1B PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA8 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 XPO1 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC NUP43 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 NUP37 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE MBOAT1 PLA2G3 PLA2G6 PLA2G4F PLA2G4E PNPLA8 PLA2G1B MBOAT2 PLAAT3 PLA2G5 LPCAT3 PLBD1 PLA2G2A-1 PLA2G4A JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLA2G12A PLA2G2E PLA2G4D LPCAT4 PLA2R1 ABHD4 PLAAT1 PLAAT2 PLAAT5 PLAAT4 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 OGG1 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism RFK ENPP1 FLAD1 SLC52A3 ACP5 SLC52A1;SLC52A2 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME ABCC2 ABCB1 PON3 PON1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells FGF10 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF CBFB CCND1 EP300 RUNX1 BRD2 RUNX3 TGFB1 KRAS HDAC4 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance NR1H2 HDLBP PCSK9 AP2A1 AP2A2 LIPA LIPC NPC1-1 LDLRAP1 AP2M1 MYLIP CUBN AMN UBA52 APOE LSR SOAT1 SOAT2 NPC2 CES3 RPS27A AP2S1 UBB;UBC LDLR APOB APOC4 APOBR NR1H3 AP2B1 NCEH1 APOC1 CLTC VLDLR APOA1 CLTA MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system UBA52 MRC1 B2M TLR2 RPS27A UBB;UBC WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis AWAT1 FAR1 FAR2 AWAT2 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System FGB TLR10 FGA TLR5 S100A9 FGG TLR4 S100A8 IKBKB TLR1 SERPING1 TLR6 TLR2 IKBKG CHUK TICAM1 TRAF3 CD14 UNC93B1 TLR7 TLR3 S100A1 RELA CD36 TIRAP LY96 HMGB1-1 BTK MYD88 NFKB1 NFKBIA F12 NFKB2 KLKB1 F2 IRAK4 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins FIP1L1 STRN WDR48 REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling SPPL2A TNFAIP3 SHARPIN USP21 USP4 CLIP3 TRAF1 TAX1BP1 CYLD OTULIN OTUD1 ULK1 RBCK1 IKBKB TBK1 IKBKG TRADD CASP8 CHUK MAPKAPK2 OPTN-1 IKBKE TRAF2 USP2 UBA52 UBE2D1 MIB2 UBE2D3-1 BIRC2 BIRC3 XIAP TNF RIPK1 RPS27A UBB;UBC FADD TNFRSF1A STUB1 RNF31 UBE2D3;UBE2D2 OTUD7B SPPL2B SPATA2 RACK1 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation DLST AMT DLD GLDC MRPS36 GCSH-3 OGDH AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ATM PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 COP1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 TP53 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA CNOT2 BUD23 RIOK1 CNOT3 PELP1 UTP15 WDR36 CNOT8 CNOT9 UTP11 TEX10 DDX52 UTP18 SENP3 GNL3 C1D NIP7 TSR3 HEATR1 DDX21 NOL9 NOC4L NOL6 EXOSC10 PES1 BMS1 RRP36 PRKCD YWHAZ RPP14 DCAF13 UTP6 UTP4 UTP3 RIOK3 KRR1 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RBM27 ZCCHC8 ZCCHC7 RBM26 TP53RK YTHDC1 ZC3H4 EPRS1 ZC3H3 YTHDC2 TENT4B PAPOLG ZC3H18 RBM7 ZFC3H1 DXO SET-1 DDX41 ELAVL1 ANP32A;ANP32D DHX9 YWHAB MAPK14 TCERG1 SNRPC SNRPA NOP2 PPP1R8;STX12 MAPK11 HTATSF1 RBM25 PPP1R10 MAPKAPK2 SNRNP70 PRPF40A TUT1 SRSF10 SRSF12 TRA2B RBM39 RBBP6 CPSF7 IGF2BP1 YBX1 HNRNPC RBMX XPO1 TGS1 ACIN1 EIF4E EIF4B EIF4G1 TRNT1 WDR82 PQBP1 SRRT ZCRB1 SNRNP200 FUS BCAS2 CTNNBL1 PRCC HNRNPA3 GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 DHX16 FIP1L1 HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 PDCD7 BUD31 SNRNP35 SNRNP25 RBM22 DDX23 ZRSR2-1 RNPC3 ZMAT5 SNRNP48 SMNDC1 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD GPATCH1 HNRNPA1-1 PNN CXorf56-1 SF3B4 SF1 SF3B5 DHX8 PRKRIP1 SF3B2 SF3B3 CWF19L2 WDR70 ISY1;ISY1-RAB43 SF3B6 DHX35 PRPF38A SF3B1 SF3A3 SMU1 NKAP UBL5 SF3A1 GCFC2 SF3A2 XAB2 PRPF18 PHF5A SDE2 FAM32A CACTIN PRPF31 TXNL4A RBMX2 SNRPN SNIP1 IK PRPF4B CHERP LENG1 PRPF4 PRPF3 SNRNP27 ZMAT2 CCDC12 ADARB1 YJU2 LSM8 PTBP1 NSRP1-1 PPWD1 PLRG1 USP39 SART1 TFIP11 SNRPA1 SYF2 DNAJC8 LUC7L3 C9orf78 PUF60 WBP4 SNRPB2 RNF113A MFAP1 SNRNP40 RBM42 BUD13 FAM50A PPIL3 PPIL4 SRRM2 AQR CRNKL1 NUP107 PRPF19 HNRNPH1 PPP2R1A HNRNPH2 SAP18 CWC25 CPSF2-1 PPIL1-1 CWC27 CPSF1 CSTF3 EFTUD2 CWC22 CPSF3 CSTF2 PRPF6 CSTF2T WDR33 PRPF8 NUDT21 CLP1 PCF11 CWC15 PAPOLA NUP160 SYMPK RBM5 NUP85 RPS27 PPP2CB;PPP2CA SEC13 NUP133 UPF1 POP5 POP7 POP1 TSEN15 NUP43 POP4 RTCB ZBTB8OS TSEN2 TSEN54 HSPB1 TSEN34 RANBP2 DDX1 C2orf49 RTRAF XPOT NOP58 FAM98B NUP37 HBS1L TTC37 NT5C3B DCPS GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 SMN2;SMN1 CLNS1A GEMIN4 GEMIN5 GTF2H2C;GTF2H2C_2;GTF2H2 GEMIN6 SNRPF CCNH RNMT GEMIN7 POLR2A GEMIN8 SNRPB POLR2B POLR2C DDX20 SNRPE-2 POLR2D POLR2E SNRPG-2 SNUPN POLR2F WDR61 POLR2G POLR2H POLR2I POLR2L RNGTT GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 IGF2BP3 ERCC2 MNAT1 IGF2BP2 AKT1 TENT4A HNRNPU CSNK1D ZFP36 PRKCA ADAR MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN HSD17B10 MRM2 MRM3 TNPO1 CNOT6L NCBP1 FASTKD5 ZNF473 TBRG4 SMG1 SMG9 NCBP2-1 SMG7 SMG8 SMG5 SMG6 TUT7 TUT4 DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 XRN2 EXOSC3 PAIP1 EXOSC2 EXOSC1 PAN2 PAN3 PPIL2 ZNF830 NOP56 TPTEP2-CSNK1E;CSNK1E SKIV2L NUP205 NUP188 AAAS NUP42 NUP62 TPR NUP88 RAE1 NDC1 NCL-1 NUP214 NUP210 NUP155 NUP153 NUP93 APOBEC1 APOBEC2 NUP50 A1CF POM121;POM121C ZFP36L1 NUP35 NUP54 URM1 WDR4 RPL4 THADA RPL30 LAGE3 RPL3 OSGEP THG1L RPL32 ALKBH8 HSPA1A;HSPA1B LCMT2 RPL31 TRMT44 RPL34 C9orf64 RPL10A TRDMT1 RPL8 PUS3 OSGEPL1 RPL9 TRMT10A RPL6 TYW5 GTPBP3 RPL7 TRMU METTL1 NSUN2 YRDC TYW3 MTO1 RPS15 METTL14 TPRKB RPS14 ADAT1 REXO2 RPS17 RPS16 METTL3 CDKAL1 TRMT1 RPL18A PNPT1 NSUN6 RPS19 SUPV3L1 RPS18 PUS7 WTAP RPL37A-1 FTSJ1 TRIT1 RPL35 ADAT3 RPL38 ADAT2 DUS2 QTRT1 TRMT9B RPS11 QTRT2 RPL39 CTU2 RPS10 CTU1 RPL15-1 TYW1;TYW1B TRMT5 RPS13 TRMT6 RPS12 RPS9 TRMT12 RPL21 TRMT13 RPS7 TRMT11 PPP1CB RPS8 TRMT61A RPL23 RPS5 RPL22 RPS6 RPSA SNW1 DDX6 RPL24 LSM1 RPL27 LSM5 RPL26 LSM4 PPP1CA RPL29 PATL1 RPL28 LSM3 LSM2 RPL10;RPL10L-1 EDC3 EDC4 LSM7 CPSF4 LSM6 XRN1 DCP2-1 DCP1A RPL3L DCP1B RPS25 RPL5-1 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 DDX5 PPP2R2A;PPP2R2D RPS4X RPL7A RPLP2 RPL36-1 RPS3A GSPT2 RPL13A-1 GSPT1 RPL11 RPS27L RPS15A RPL14 RPS3 PABPC1;PABPC3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A PABPN1-1 RPL22L1 CNOT10 UPF2 FAU RAN RPL26L1 CNOT11 ETF1 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 GLE1 NXF2;NXF2B;NXF5-1 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 LSM10 PSMD8 THOC6 SLBP SRRM1 PSMD6 LSM11 DDX39A PSMD7 DDX39B PSMD2 SARNP PSMD3 ZC3H11A PSMD1 SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A PSMC2-1 POLDIP3 PSMA5 SRSF1 PSMA6 NXF1 PSMA3 U2AF2 FYTTD1-1 PSMA4 PSMA1 DHX38 UBA52 SRSF11 MAGOH;MAGOHB SRSF4-1 PSMD12 CHTOP PSMD11 PSMD14 ALYREF UPF3B PSMD13 RNPS1 PSMA7 PSMB6 PSMB7 TNKS1BP1 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 HSPA8 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 TRMT112 LTV1 RPP30 RRP1 FCF1 THUMPD1 RRP9 FBL LOC102724159;PWP2 MTREX UTP14C;UTP14A SLIRP MTPAP RPP38 TRMT61B DIMT1 LRPPRC IMP3 WDR75 IMP4 FTSJ3 EBNA1BP2 DKC1 RPP21 NHP2 RPP25 UTP25 ISG20L2 SNU13 RRP7A EMG1 PDCD11 ERI1 DHX37 UTP20 NOP14 PNO1 RPP40 RCL1 TBL3 LAS1L EIF4A2 MPHOSPH10 EIF4A1 NOL11 NOL12 NOP10 RBM28 DDX49 CNOT4 DDX47 WDR3 CNOT6 NAT10 WDR46 WDR43 CNOT7 NOB1 RIOK2 CNOT1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway LTBR PSMD8 PSMD6 TNFSF11 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 CHUK FBXW11 PSMC2-1 PSMA5 PSMA6 TRAF3 FASLG PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 TNF PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 TNFRSF1B PSMA2-1 TNFRSF1A SEM1 TNFRSF14 PSMC5 NFKB2 PSMC6 PSMC3 PSMC4 PSMC1 MAP3K14 TNFRSF8 RELB TNFRSF4 TNFRSF17 TRAF2 TNFRSF9 TNFSF13B CD40LG TNFRSF25 TNFSF18 TNFSF14 TNFSF15 EDARADD EDAR LTA BIRC2 TNFRSF18 LTB BIRC3 TNFRSF11B TNFRSF11A UBA3 CD27 TNFRSF13B TNFRSF13C EDA2R TNFRSF12A CD70 EDA TNFSF4 TNFSF9 TNFSF8 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE ABCC6 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina CDK1 PRKCA LEMD2 EMD PRKCB LPIN1 LEMD3 LPIN2 LPIN3 CTDNEP1 CNEP1R1 LMNB1 CCNB1 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion OSGEPL1 GTPBP3 TRMU YRDC TRMT10C PRORP MTO1 HSD17B10 TRMT61B TRIT1 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type MMAB SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3CB HRAS PIK3R2 SOS1 PIK3R1 PIK3CA STAT1 PDGFRA STAT3 NRAS BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins LTA4H ALOX5 ALOX15 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling JAK2 DUSP6 DUSP7 BRAP FGB FGA KSR1 VWF SPRED3 FGG SPRED2 KSR2 APBB1IP SPRED1 CNKSR2 CNKSR1 RAF1 TLN1 ATG7 MAP3K11 VCL CALM3;CALM1 PAPSS1 NF1 TENT4A AKAP9-1 KIAA1549 MPRIP TRIM24 FXR1-1 AGTRAP AP3B1 SND1 ESRP1 PPP1CB KDM7A FAM114A2 ZC3HAV1 TRAK1 BCL2L11 LMNA MARK3 AGK QKI CLCN6 FAM131B AGGF1 DUSP16 SRC CAMK2B CAMK2D CAMK2A YWHAB NRAS RAP1A MAP2K2;MAP2K1 MAPK1 HRAS CAMK2G MAPK3 BRAF PPP1CC DUSP10 ITGA2B DUSP8 FN1 DUSP9 MRAS SHOC2 CSK KRAS ITGB3 ARAF PEBP1 ARRB1 PHB IQGAP1 ARRB2 RAP1B DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation HPSE2 AGRN CTSV;CTSL NAGLU IDS SDC1 HPSE SGSH GPC1 IDUA HSPG2 GPC3 GPC2 SDC4 GPC5 SDC2 GPC4 SDC3 GPC6 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant F9 F10 F8 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling GNAS-1 ADCY4 PRKACA-1 ADCY9 PRKAR2A PRKACB-1 PRKAR1B ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR1A PRKAR2B ADCY5 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling JAK2 TYK2 EBI3 JAK1 IL6ST STAT4 IL12RB2 CANX STAT1 IL12A STAT3 IL27RA PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation DLST DBT FDX1 NDUFAB1 NFU1 LIAS LIPT2 LIPT1 GCSH-3 DLAT TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer SMAD2;SMAD3 TGFBR1-1 TGFBR2 TGFB1 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism ADAL NT5C2 ADH1C;ADH1B;ADH1A PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling MAPK1 MAPK3 APP SAA2;SAA1 CAPZA1 CAPZA2 LGALS3 DDOST HMGB1-1 AGER S100A12 PRKCSH CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage GSDMD CASP3 CASP5;CASP4 IL18 IL1B SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs ACSBG1 SLC27A3 ACSBG2 ELOVL6 ELOVL3 HACD1 TECR HSD17B3 HSD17B12 HACD3 ACSL1 HACD2 HACD4 ELOVL1 ELOVL4 ELOVL2 ACSL6 ACSL5 ACSL4 ACSL3 ELOVL7 TECRL ELOVL5 ACSF3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes NFE2L2 ME1 IDH1 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair POLD2 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 ISY1;ISY1-RAB43 XAB2 XRCC1 DDB1 LIG3 CUL4A CUL4B COPS5 AQR PRPF19 PARP1 UBE2V2 GPS1 COPS4 COPS2 CETN2 ELL LIG1 ACTL6A RNF111 DDB2 TCEA1 UBA52 YY1 RPS27A UBB;UBC RBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RUVBL1 POLR2A NFRKB POLR2B PARP2 POLR2C UVSSA ACTR5 POLR2D PIAS3 ZNF830 USP45 POLR2E UBE2I RAD23A POLR2F CHD1L POLR2G ACTR8 POLR2H ERCC5;BIVM-ERCC5 POLR2I RAD23B POLR2L ERCC6 INO80C INO80B GTF2H1 INO80E INO80D PIAS1 XPA GTF2H3 COPS7B ACTB-1 COPS7A GTF2H4 ERCC8 XPC CDK7 POLR2J;POLR2J2;POLR2J3 TFPT SUMO1 MCRS1 ERCC3 INO80 SUMO3 ERCC2 COPS3 MNAT1 SUMO2 COPS6 ERCC4 ERCC1 COPS8 USP7 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 PPIE PCNA POLD3 POLD4 UBE2N POLD1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription TEAD1 TEAD2 TEAD3 TEAD4 NFE2L2 FOS H2AJ JUN BRD4 SUZ12 H2BC5 STAT1 STAT3 H2BC1 FOSB RELA H2AC4 MYCN KMT2A KMT2C TCF7 NFKB1 CTNNB1 NFKB2 DPY30 H2BC21 WDR5 EED H2AZ2;H2AZ1 IRF1 LEF1 H2AC14 MYC RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L2 ATF3 TCF7L1 EPAS1 H2BC15;H2BC3;H2BC11;H2BC12 HIF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 WWTR1 JUND EP300 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L CREBBP SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease POLR2E POLR2F POLR2G POLR2H HRAS POLR2I POLR2L NCBP2-1 FRS2 GTF2F1 GTF2F2 PIK3CA FGF1 POLR2J;POLR2J2;POLR2J3 FGF2 FGF3 FGF4 FGFR2 FGF6 FGF7 GAB1 FGF9 SOS1 FGF20 FGF23 FGF22 PLCG1 FGF16 FGF18 FGF10 PIK3R1 NCBP1 POLR2A POLR2B NRAS POLR2C POLR2D DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GP1BB GP5 F9 F11 GP1BA GP9 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling GNB1 GNB4 GNB3 GNB5 GNAS-1 ADCY4 GNAI3 PRKAR2A ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 ADCY6 PRKAR1A GNAI2 ADCY5 GNG10 ITGB1 GNG2 GNG5 GNG4 GNG8 GNAT3 SRC PRKACA-1 ADCY9 PRKACB-1 PRKAR1B ITGA5 GNAZ PRKAR2B GPER1 GNGT1 GNG13 GNB2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGM PIGL PIGG PIGF PIGH PIGX-1 PIGO PIGN PIGP PIGZ PIGW PIGV DPM2 PIGC PIGB PIGA SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 FGF4 HRAS FGF9 SOS1 FGF20 FGF23 FGF16 FGF18 NRAS FGF1 FGF2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions NTN4 DRP2 PDGFA CASK AGRN TTR SGCE SGCD SGCA SGCB DMD ITGB5 SGCG SNTA1 DTNA TGFB1 DTNB SGCZ SSPN SNTB1 SNTB2 TNC ITGAV PDGFB DAG1 PRKCA LAMA5 NRXN1;NRXN3;NRXN2 LAMB3 LAMA2 LAMB2 LAMA1 LAMC3 FGF2 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 VTN HSPG2 SDC4 ITGB1 SDC2 ACTN1 DDR1 SDC3 ITGB4 ITGA2 TRAPPC4 ITGA6 DDR2 THBS1 SDC1 UTRN ITGB3 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release STEAP3 TP73 AIFM2 BBC3 PRELID1 BID ZNF420 BNIP3L PMAIP1 ATM TP53INP1 TP53 TP53BP2 TP63 BAX PRELID3A PPP1R13B CREBBP KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants FLT3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 JAK2 PPP2R2A;PPP2R2D E2F4-1 PPP2R1B CDKN2D PPP2R1A CDKN2B CDKN2C CDKN2A CDK7 SKP1 MNAT1 UBA52 CUL1 PTK6 CKS1B RBL2 LYN RBL1 RB1 PPP2CB;PPP2CA CDKN1C ABL1 CDKN1A RPS27A CDKN1B UBB;UBC CCND3 CCND2 CCND1 E2F1 E2F2 E2F5 E2F3 SKP2 PPP2R3B TFDP1 CCNH CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA AURKA PHLDA1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome ZCRB1 VHL RB1 DDX5 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism SGPP2 PLPP1 SGPP1 SGPL1 ACER2 ACER1 ALDH3B2;ALDH3B1 ACER3 PLPP3 PLPP2 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm TEAD2 TEAD4 FOXA2 TCF7 LEF1 SMAD2;SMAD3 CTNNB1 TBXT NOTO YAP1-1 FOXA1 FOXH1 SHH ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria YWHAQ YWHAG PPP3CC BID YWHAH PPP3R1 BAD YWHAE AKT2 SFN YWHAZ AKT3 AKT1 BCL2 YWHAB PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly MTTP PRKACA-1 SAR1B PRKACB-1 A2M ZDHHC8 ABCA1 APOC4 APOB APOC3 APOA2 APOC2 APOA4 APOC1 APOE APOA1 P4HB SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 MAMLD1 CNTN1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B MDK HES5 GZMH;GZMB-1 UBA52 MIB2 NOTCH2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B RPS27A NEURL1 UBB;UBC MAML2 HES1 MAML1 EP300 FCER2 RBPJ SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins TSG101 MVB12B MVB12A VPS37C VPS37D VPS37A RPS27A UBB;UBC VPS37B UBAP1 NMT2 VPS28 UBA52 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome ZCRB1 VHL RB1 DDX5 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t PGM1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity PTPN11 CBFB TNRC6C RUNX1 PML TNRC6B SRC CCND3 AGO3;AGO1 MOV10 CCND2 AGO4 CCND1 AGO2 CDK6 TNRC6A-1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 FGF4 FGF9 FGF20 FGF23 FGF16 PLCG1 FGF18 FGF1 FGF2 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis HMGCS1-1 GGPS1 LSS MVD IDI1 MVK IDI2 ACAT2 PMVK FDFT1 FDPS PLPP6 SQLE DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 PROC PROS1 F5 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A6 LCN1 SLC27A1 APOD LCN15 LCN12 SLC27A4 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f MPDU1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOB MAOA DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g ALG12 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters TFAM-1 TFB2M POLRMT MTERF1-1 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress STOML2 EIF2S3;EIF2S3B EIF2AK1 EIF2S1 PHB2 OMA1 DELE1 YME1L1 EIF2S2 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway MED9 MAP1B JAK1 CDK19 CSNK2A1;CSNK2A3 MED28-1 CD14 PPP1CB TLR7 TLR3 PPP1CA KPNB1 EIF2AK2 ISG15 SEC11A SEC11C MED31-1 TYK2 IFNAR1 HSP90AA1 PPP1CC TLR6 TLR2 SPCS3 HSP90AB1 STAT2 SPCS2 SPCS1 CUL5 CCNC-1 HSPG2 SDC4 SDC2 SDC3 H2BC15;H2BC3;H2BC11;H2BC12 MED16 LY96 MED15 MED17 MED12 MED14 ELOC-1 MED13 SDC1 XPO1 MED10 ELOB EP300 FURIN MED27 MED1 MED26 CREBBP MED23 MED8 MED25 MED4 MED6 MED24 MED7 MED20 BECN1 TLR4 EGFR IFNB1-4 GPC1 GPC3 UBA52 GPC2 GPC5 GPC4 GPC6 AGRN RPS27A UBB;UBC RBX1 HSPA8 MED19 MED18 MED11 MED29 MED22 MED21 MED30 IRF3 DDX58 IFIH1 MAVS CLEC4M;CD209-2 TRIM25 MED13L CSNK2A2 CSNK2B CX3CR1 RAB5B RAB5C IGF1R NCL-1 ARIH1 RAB5A BCAP31 UBE2L6 HERC5 CDK8 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide HBA2;HBA1 CA1 CA2 CA4 RHAG HBD;HBB SLC4A1 AQP1 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage ASCC1 ASCC2 ASCC3 ALKBH3 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression SIRT1 TTF1 SIN3B SAP130 SIN3A UBTF H2AJ SAP30BP POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H BAZ2A TAF1D HDAC2 TAF1B SMARCA5 TAF1C TAF1A H2BC5 HDAC1 H2BC1 H2AC4 SUV39H1 RRP8 ARID4B GTF2H2C;GTF2H2C_2;GTF2H2 CCNH POLR2E POLR1C POLR2F H2BC21 SAP30 POLR1D POLR2H POLR2L GTF2H1 H2AZ2;H2AZ1 SAP30L GTF2H3 SAP18 SUDS3 GTF2H4 CDK7 ERCC3 ERCC2 MNAT1 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 TBP H2AB2;H2AB3;H2AB1 DNMT3B DNMT1 MBD2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules SLC35B3 SLC35B2 SLC27A6 LCN1 SLC28A2 SLC29A1 SLC28A3 SLC35A1 SLC29A2 SLC35B4 SLC35D2 SLC27A4 SLC35D1 SLC33A1 SLC35A3 SLC25A5 SLC5A6 SLC25A4 LCN15 SLC25A6 LCN12 ARL2BP SLC29A3 PDZD11 SLC35A2 SLC29A4 SLC35C1 ARL2 SLC28A1 SLC27A1 APOD MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 FKRP LARGE1 LARGE2 DAG1 RXYLT1 POMGNT1 CRPPA B4GAT1 SLC35A1 CHST10 FKTN SLC35A4 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse HLA-DQB2;HLA-DQB1 CD4 PTPN22 HLA-DPA1 HLA-DPB1-1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DRA ZAP70 CD3G LCK CD3E CD3D CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway CASP8 NFKB1 RELA PYCARD MALT1 IL1B G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase E2F1 E2F3 CCNA2-1 CCNA1 CDK2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding CCT5 GNB1 CCT4 GNB4 GNB3 GNB5 CCT6A GNAQ PDCL CSNK2A1;CSNK2A3 RGS11 CCT6B CSNK2A2 GNG10 CSNK2B RGS9 RGS6 GNG2 RGS7 GNG5 GNG4 CCT3 GNG8 CCT2 TCP1 GNA14 GNA15 GNGT1 GNA11 GNG13 CCT8 GNB2 CCT7 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair HGS NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 TAB2 NCOR1 PSENEN PSEN2 PSEN1 APH1A NCSTN ESR1 APH1B CSN2-1 MXD4 CXCL12 PGR STMN1 ADAP1 YAP1-1 GFAP APOE EREG BTC HBEGF SRC ADAM17 STAT5A NRG2 SPARC NRG3 NRG4 NRG1 WWOX DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly NUP107 NEK9 NEK6 NEK7 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 CCNB2 RAE1 CCNB1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 CDK1 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement C8G C6 C7 C9 C5 C8B C8A CLU EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells EFNA2 RAC1 VAV2 PSENEN PSEN2 PSEN1 EPHA1 APH1A NCSTN APH1B AP2A1 AP2A2 CLTCL1 AP2M1 TIAM1 FYN EPHB2 DNM1 ADAM10 CLTB LYN EPHB6 YES1 AP2S1 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 MMP9 EPHA3 EPHA10 EFNA5 VAV3 AP2B1 EFNA4 EFNB2 EFNB1 EFNB3 EPHA2 CLTC EFNA1 CLTA EFNA3 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events NCOR1 DYNC1I2 TBL1XR1 EGFR NUP43 TRIM28 DYNC1I1 RANBP2 DYNC1H1 SUZ12 ELK1 H2BC5 H2AC16;H2AC11 H2BC1 NUP37 PML H2AC4 NCOR2 NFKB1 DAXX GPS2 NUP107 H2BC21 EED DYNC1LI1 DYNC1LI2 H2AC14 NUP205 NUP188 RBBP4 AAAS NUP42 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBX1 NUP62 NUP160 TPR RBBP7 ITGB1 NUP88 RAE1 NDC1 NUP85 NUP214 NUP210 NUP155 HDAC3 NUP153 H2BC15;H2BC3;H2BC11;H2BC12 NUP93 NUP50 POM121;POM121C NUP35 NUP54 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC13 H2AC20 NUP133 EZH2 H2BC18 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation UGDH SLC35D1 UXS1 UGP2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABHD10 SLC35D2 UGT2A1 UGT1A1;UGT1A6 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants KIT GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle SLC17A7 RAB3A RIMS1 SLC1A1 PPFIA1 PPFIA4 SLC1A2 PPFIA3 PPFIA2 SLC1A3 GLS ARL6IP5 UNC13B SLC1A6 SNAP25 CPLX1 SLC1A7 GLS2 SYT1 TSPOAP1 SLC38A2 STX1A VAMP2 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 GGCX TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH VCP-1 POLH RFC5 RFC3 RPA1 RFC4 RPA2 RFC1 RFC2 NPLOC4 RCHY1 RPA3 SPRTN RPS27A UBB;UBC PCNA UBA52 UFD1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis GFUS GMDS FCSK SLC35C1 FPGT FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation FCGR3A;FCGR3B SYK FGR FCGR1A LYN CD3G FYN HCK YES1 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism GSTZ1 HGD TAT FAH QDPR HPD IL4I1 PAH PCBD1 KYAT1 ASRGL1 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling GGA3 HGF GAB1 MET CRK RAB4A CRKL ARF6 RAB4B LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling APOB CETP MTTP P4HB APOF MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation FASTKD2 FASTKD5 TBRG4 GRSF1 SLIRP REXO2 PNPT1 LRPPRC SUPV3L1 BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins CYP2D6;LOC107987479;LOC107987478-1 ALOX5 CYP2C9;CYP2C19 CYP1A2 EPHX2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation QARS1 TARS1 AARS1 RARS2 HARS1 RARS1 AARS2 FARSA PARS2 FARSB MARS2 MARS1 DARS2 YARS2 YARS1 HARS2 FARS2 NARS1 WARS2 CARS1 PPA1-1 VARS1 LARS2 DARS1 GARS1 SARS2 WARS1 PPA2 LARS1 NARS2 TARS2 IARS2 EEF1E1 VARS2 KARS1 CARS2 EARS2 IARS1 AIMP1 AIMP2 EPRS1 SARS1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation GSTA3;GSTA5;GSTA1;GSTA2 RALA-1 PPIA HNRNPF HSPA9 CDC42 TALDO1 PAK2 SOD2 LMNB1 SOD1 CFL1 CA1 HNRNPA2B1 ARF1 CAPZA1 PSME2 IFNG PITPNA TCP1 SERPINB2 AIP MIF SNRPA1 LCP1 CNN2 HNRNPDL IL10 STAT4 MTAP PDCD4 RPLP0 MSN ANXA2 GSTO1 RAP1B TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors TFAP2A TFAP2C CITED2 PITX2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 HAUS8 HAUS7 PCNT OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP250 CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B TPX2 HMMR HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CEP57 CETN2 CEP164 ACTR1A AURKA MAPRE1-1 CNTRL CEP290 CKAP5 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RB1 CDKN1C CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 TFDP1 CDK6 TFDP2 CCNE2 CDK4 CCNE1 CDK2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression TEAD1 TEAD2 JAK1 TEAD3 TEAD4 FOS PDCD1LG2 H2AJ B3GNT3 CUL3 CSNK2A1;CSNK2A3 AGO3;AGO1 DERL3 DERL1 DERL2 OS9 SPOP BRD4 SUZ12 H2BC5 STAT1 STAT3 MIB2 H2BC1 FOSB VCP-1 TUSC3 NEK2 H2AC4 MYCN TMEM258 CD274 KMT2A KMT2C TCF7 SEL1L CCND1 CTNNB1 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 CDK4 GSK3B DPY30 H2BC21 WDR5 YWHAG EED H2AZ2;H2AZ1 DDOST DAD1 IRF1 PRKAA1 PRKAA2 LEF1 RNF5 ERLEC1 RBBP4 RBBP5 YAP1-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L2 TCF7L1 TNRC6A-1 TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 PDCD1 TNRC6B EP300 CREBBP PSMD8 NFE2L2 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PSMC2-1 PSMA5 JUN PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 NFKB1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 H2AC14 MYC PRKAB2 CSNK2A2 PRKAB1 CSNK2B ATF3 RPN2 EPAS1 RPN1 HIF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 WWTR1 JUND ERLIN1 ERLIN2 MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 EZH2 PRKAG1 PRKAG2 ASH2L MAGT1 PRKAG3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF COL4A3 COL9A1 COL6A3 COL4A5 SPP1 COL9A3 COL6A6 COL6A5 GRB7 RASA1 COL9A2 PDGFRB PLCG1 STAT1 STAT3 PLAT SRC STAT5A STAT5B STAT6 CRKL NRAS PIK3CB HRAS PDGFB PTPN12 PIK3CA PDGFD RAPGEF1 THBS4 SOS1 THBS3 CRK NCK2 NCK1 PTPN11 PIK3R2 PIK3R1 THBS2 THBS1 FURIN COL4A2 COL4A1 PLG COL6A2 PDGFRA COL4A4 BCAR1 COL6A1 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation FGFR4 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling MAPK1 MAPK3 BRAF FRS2 PPP2R1A FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 UBA52 MKNK1 SPRY2 FGF10 PTPN11 PPP2CB;PPP2CA RPS27A UBB;UBC CBL CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors RAMP2 CALCRL CALCB;CALCA RAMP3 RAMP1 ADM IAPP CALCA CALCR ADM2 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling FGB FGA VWF FGG SYK PDPK1 APBB1IP RASGRP1 TLN1 ITGA2B FN1 SOS1 CRK SHC1-1 RAPGEF3 AKT1 RAPGEF4 CSK SRC ITGB3 PTPN1 RASGRP2 BCAR1 RAP1B RAP1A PTK2 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 NEIL3 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l ALG9 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis SYK FGR ADCY4 PRKAR2A HCK ADCY3 PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 ADCY7 ADCY6 PRKAR1A ADCY5 PLCG1 FCGR1A FYN AHCYL1 LYN PRKACA-1 ADCY9 PRKACB-1 YES1 PRKAR1B FCGR3A;FCGR3B PRKAR2B IL10 PLCG2 CD3G ITPR1 ITPR2 ITPR3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO SUMO3 UBE2I SUMO2 RWDD3 UBA2 SAE1 SENP5 SENP2 SENP1 SUMO1 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins UBE2I RANGAP1 SUMO1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG ZCRB1 ISCU PIK3R4 GPC1 NRP1 HSPG2 GPC3 TMPRSS2 VHL ACE2 GPC2 SDC4 GPC5 SDC2 GPC4 PIK3C3 CHMP4C SDC3 GPC6 CHMP4B CHMP3 VCP-1 CHMP4A AGRN CTSV;CTSL CHMP6 CHMP7 RB1 SDC1 FURIN CHMP2B CHMP2A DDX5 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling ITGB3BP PRDM4 RAC1 ARHGEF26 SMPD2 PSENEN PSEN2 PSEN1 KALRN MAPK8 APH1A NCSTN IKBKB APH1B VAV1 LINGO1 MAG OMG MCF2 RTN4 BAD YWHAE HDAC2 TIAM1 UBA52 ARHGEF10L AKAP13 HDAC1 ARHGEF11 ARHGEF10 BCL2L11 NGFR ARHGEF12 SQSTM1 RELA ARHGEF17 ARHGEF3 ARHGEF1 ARHGEF2 ADAM17 RPS27A UBB;UBC NFKB1 ECT2 RASGRF2 CASP3 MAGED1 NFKBIA NET1 VAV3 ARHGEF40 PLEKHG2 ARHGEF15 VAV2 PLEKHG5 ARHGEF19 TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 NGF FGD1 FGD2 ARHGEF18 FGD3 GNA13 FGD4 RHOA IRAK1 ARHGEF33 ARHGEF37 SOS1 ARHGEF39 ARHGEF38 BEX3 SOS2 TRIO ITSN1 CASP2 HDAC3 ABR PREX1 ARHGDIA MCF2L PRKCI RIPK2 MYD88 ARHGEF16 TRAF6 AATF ARHGEF5 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling IL2RB SOS2 IL15 JAK1 IL2RG STAT5A STAT5B SOS1 SHC1-1 GRB2 GAB2 STAT3 JAK3 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes TSC2 TSC1 RRAGA RRAGC RRAGB RRAGD YWHAH SLC38A9 RHEB AGO3;AGO1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 YWHAE YWHAZ GPI GLS2 PRDX2 TXNRD1 PRDX1 COX7B SESN3 SESN2 COX7C COX8A COX8C TP53 COX5B COX5A COX6C YWHAB TIGAR COX7A2L-1 COX6A1 COX6A2 MLST8 YWHAG G6PD SCO2 COX6B2 DDIT4 COX6B1 PRKAA1 COX7A2 PRKAA2 AKT2 TP63 SFN AKT3 AKT1 PRKAB2 COX4I1 COX4I2 PRKAB1 PTEN TNRC6A-1 TXN MTOR TNRC6C YWHAQ TNRC6B CYCS-1 RRM2B MOV10 AGO4 GLS AGO2 PRKAG1 PRKAG2 RPTOR NDUFA4 PRKAG3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 HAUS8 HAUS7 PCNT OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP250 CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B TUBGCP2 MZT2A;MZT2B TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 TUBG2 NME7 MZT1 HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CEP57 CETN2 CEP164 ACTR1A MAPRE1-1 CNTRL CDK11A;CDK11B CEP290 CKAP5 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers SMARCB1 ARID2 ACTB-1 SMARCC1 SMARCC2 BCL11A SMARCD1 SMARCD2 SMARCA2 SMARCD3 SMARCE1 SMARCA4 PHF10 BCL11B ARID1A ARID1B BICRAL BICRA BCL7A BRD9 PBRM1 BCL7C DPF1 BCL7B DPF2 DPF3 SS18 ACTL6B SS18L1 ACTL6A BRD7 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle SLC18A2 CASK SYN3 LIN7A SYN2 LIN7C SYN1 LIN7B RAB3A RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 UNC13B SNAP25 CPLX1 SYT1 TSPOAP1 APBA1 STX1A VAMP2 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB2 KCNMB3 KCNN1 KCNMB4 KCNN3 KCNN4 KCNMB1 KCNMA1 KCNN2 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses SYT10 NTRK3 GRIN2B SYT2 SYT1 STX1A CASK GRIA1 LIN7A LIN7C LIN7B EPB41L1 GRIA3 GRIA4 PPFIA1 GRIN2C PPFIA4 HOMER3 PPFIA3 PPFIA2 EPB41 GRIN1 STXBP1 GRIN2D EPB41L5 GRIN2A DBNL EPB41L2 DLG2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 PTPRS PTPRF SIPA1L1 DLGAP1 DLGAP3 DLGAP4 BEGAIN APBA3 APBA2 LRRC4B SYT7 SHARPIN LRFN3 PTPRD LRFN2 LRFN4 LRFN1 LRRTM3 DLG1 LRRTM4 DLG3 LRRTM1 DLG4 LRRTM2 NRXN1;NRXN3;NRXN2 IL1RAPL2 IL1RAPL1 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 FLOT1 NLGN2 NRXN3 FLOT2 NRXN2 SLITRK2 SLITRK1 SLITRK4 SLITRK6 PDLIM5 NLGN4X;NLGN4Y SYT12 APBA1 SYT9 GRM1 GRM5 SLITRK3 SLITRK5 RTN3 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants ALK RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle TXNL1 COPS4 CCT2 COPS2 PDE5A HNRNPC VIM SRRM1 RBMX DBN1 CUL3 ROCK1 ROCK2 GPS1 RHOBTB1 TRA2B STK38 MYO6 RBBP6 SPEN RNF20 CPSF7 CCT7 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis RAC1 PLD1 PRKCE PLA2G6 VAV1 HCK ELMO1 NF2 PAK1 PRKCD PLCG1 LIMK1 CYFIP2 WIPF1 WIPF2 WIPF3 AHCYL1 BTK NCKIPSD FCGR3A;FCGR3B PLCG2 VAV3 MYH9 ITPR1 ITPR2 MYO5A ARPC4 ARPC5 ITPR3 PTK2 ARPC2 ARPC3 PIK3CB MAPK1 ACTR3-1 ARPC1B VAV2 ARPC1A WASL MAPK3 HSP90AA1 ACTR2 SYK FGR PIK3CA ACTB-1 NCKAP1 WASF1-1 WAS HSP90AB1 CDC42 CRK ACTG1 NCK1 FCGR1A PLD2 FYN WASF3 MYO10 CYFIP1 MYO1C CFL1 PIK3R2 PIK3R1 PLD3 PLPP5 PLPP4 NCKAP1L WASF2 LYN MYO9B ABL1 BAIAP2 YES1 ABI2 PLD4 ABI1 ELMO2 CD3G DOCK1 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy CETN1 PARK7 RNASE1 ARL13B PLIN2 UBA52 CFTR HDAC6 CHMP4C PCNT CHMP4B CHMP3 CHMP4A TSG101 CHMP6 CHMP7 MVB12B HBD;HBB MVB12A VPS37C VPS37D RPS27A VPS37A UBB;UBC VPS37B PLIN3 UBAP1 HSPA8 VPS28 CHMP2B CHMP2A IFT88 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions NRP2 ANK1 CNTN2 DLG1 DLG3 DLG4 NRCAM SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts CYP27A1 HSD3B7 AKR1D1 OSBP NR1H4 CYP7B1 CYP7A1 RXRA ACOT8 HSD17B4 CYP8B1 BAAT SLC27A2 ACOX2 CYP46A1 CYP39A1 AMACR ABCB11 CH25H SLC27A5 OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL1A NCOA1 OSBPL2 NCOA2 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels KCNIP3 KCNIP1 KCNIP2 KCNIP4 KCND1 KCND2 KCND3 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis A4GALT B3GALT4 CERK ST3GAL5 B4GALT6 ST8SIA5 B4GALT5 ST6GALNAC6 UGCG UGT8 B3GNT5 B4GALNT1 B3GALNT1 FUT2 FUT1 GAL3ST1 ST6GALNAC5 ST3GAL2 ST3GAL3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis CLSPN YWHAH TICAM2 TICAM1 PRKCD YWHAZ CD14 PAK2 STAT3 TP73 KPNB1 CDH1 CTNNB1 TP53BP2 E2F1 TFDP1 FNTA TFDP2 YWHAB PTK2 MAPK1 MAPK3 YWHAG ROCK1 PMAIP1 SFN SPTAN1 DCC CASP6 YWHAQ LY96 VIM BBC3 ARHGAP10 PPP3CC BMF H1-0 H1-3 H1-2 H1-5 H1-4 OMA1 STK24 GSN STK26 OPA1 DNM1L ACIN1 MAPK8 TLR4 PSMD8 PSMD6 PSMD7 PSMD2 BID PSMD3 PSMD1 CDKN2A PPP3R1 BMX SATB1 BAD CASP9 YWHAE PSMC2-1 AVEN PSMA5 DIABLO-1 PSMA6 UACA FASLG PSMA3 PSMA4 PSMA1 UBA52 BCL2 PSMD12 LMNB1 PSMD11 BCL2L1 PSMD14 APC PSMD13 NMT1 BCL2L11 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 APIP PSMB3 PSMB1 RPS27A UBB;UBC DAPK1-1 ADRM1 UNC5A CASP7 DSP UNC5B DBNL PSMA2-1 TJP1 TP53 MAGED1 SEM1 CASP3 GAS2 DAPK2 MAPT OCLN-1 DAPK3 DSG1 ADD1 PSMC5 PKP1 APPL1 PLEC PSMC6 DSG2 PSMC3 DSG3 PSMC4 PSMC1 TJP2 TRADD CASP8 TNFSF10 AKT2 TP63 GZMH;GZMB-1 AKT3 AKT1 PPP1R13B TRAF2 DFFB DFFA HMGB2 KPNA1 BCAP31 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A APAF1 BIRC2 XIAP CYCS-1 HMGB1-1 RIPK1 BAK1 FADD GSDMD C1QBP FAS BAX PRKCQ GSDME SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer HBEGF CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA RPS27A UBB;UBC CBL GAB1 SOS1 SHC1-1 TGFA PLCG1 EGF UBA52 AREG EREG BTC NRAS EPGN SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events CDK5 PPP1CA PPP3CA PPP3CC PPP2R1B PPP3CB PPP2R1A PPP2CB;PPP2CA PRKACA-1 PRKAR2A PRKACB-1 PRKAR1B PPP3R1 PPP1R1B CALM3;CALM1 PRKAR1A PRKAR2B PDE4D-1 PPP2R5D PDE4A PDE4C FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN2;FCN1 MASP1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism HLCS MCCC2 ACACA MCCC1 PC PCCA BTD PCCB INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida B4GALT1 ADAM30 ADAM2 ZP1 ADAM21 ADAM20 ZP2 ZP3;POMZP3 ZP4 SPAM1 OVGP1 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) CTSS RAC1 VAV2 CTSB CTSV;CTSL ARHGEF4 FARP2 CTNNA1 SRC CTNND1 RPS27A ELMO1 UBB;UBC CDH1 CDH11 CTNNB1 JUP CDC42 CBLL1 TIAM1 UBA52 DOCK1 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) ALOX5 PTGS2-2 ALOX15 ALOX5AP PTGR1-1 EPHX2 HPGD LTA4H CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 LTC4S CYP1A2 CYP1A1 GSTM4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ALOX12 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis B3GALT4 ST3GAL6 B3GALT5 B4GALNT2 FUT6;FUT5;FUT3 ST6GALNAC6 B3GALT2 FUT2 B3GALT1 ST3GAL4 FUT4 FUT7 FUT9 ST3GAL3 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) SMARCB1 ACTB-1 SMARCC1 SMARCC2 BCL11A SMARCD1 SMARCD2 SMARCA2 SMARCD3 SMARCE1 SMARCA4 PHF10 BCL11B ARID1A ARID1B BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 ACTL6B SS18L1 ACTL6A NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAB2 TAB1 CARD9 IKBKB NOD1 NOD2 IRAK2 IKBKG MAP3K7 CHUK CASP9 APP NLRC4 BCL2 BCL2L1 RELA PYCARD NFKB1 MEFV AIM2 NFKB2 NLRP3 TNFAIP3 PSTPIP1 CYLD MAPK14 TXNIP MAPK12 MAPK13 HSP90AB1 MAPK11 CASP8 CASP1 IRAK1 NLRP1 P2RX7 SUGT1 TXN CASP2 MAP2K6 BIRC2 BIRC3 RIPK2 HMOX1 CASP5;CASP4 ITCH PANX1 TRAF6 UBE2V1 AAMP UBE2N TAB3 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase LBR ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC16 CDC27 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SPAST CC2D1B VPS4A SIRT2 IST1 VRK1 LEMD2 ESPL1 XPO1 TNPO1 PTTG1;PTTG2 TUBA1C TUBA1A TUBB1 LMNB1 RCC1 TUBB2B;TUBB2A TUBA4A TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 NUP205 NUP188 NUP62 BANF1 CHMP4C NDC1 CHMP4B ANKLE2 CHMP3 CHMP4A NUP155 CHMP6 NUP93 CHMP7 POM121;POM121C NUP35 NUP54 EMD LEMD3 CHMP2B CHMP2A KPNB1 PPP2R2A;PPP2R2D ERCC6L NUP107 ZWILCH BUB1B SMC3 PMF1;PMF1-BGLAP CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 CLIP1 DYNC1LI2 ZW10 MAD1L1 CENPN-2 CENPS-CORT;CORT;CENPS MIS12-1 CDCA5 CDCA8 PDS5B PDS5A NUP160 RAN SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT KIF18A STAG1 STAG2 RPS27 AHCTF1 PPP2CB;PPP2CA MAPRE1-1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C RANGAP1 SMC1A CKAP5 KIF2A INCENP BIRC5 KIF2C KIF2B ITGB3BP PAFAH1B1 DYNC1I2 CENPA AURKB NSL1 CENPC PSMD8 NUP43 BUB3 PSMD6 BUB1 PSMD7 DYNC1I1 PSMD2 CLASP1 PSMD3 CLASP2 PSMD1 CENPT RANBP2 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMC2-1 CENPI PSMA5 TAOK1 PSMA6 CENPK PSMA3 CENPL PSMA4 CENPM PSMA1 B9D2 UBA52 CENPO CENPP CENPQ PSMD12 SPC24 PSMD11 SPC25 PSMD14 MAD2L1 PSMD13 NUP37 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UBE2I SUMO1 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs MYH10 FLNA RAC1 MYL6 PPP1R12A PPP1R12B CTTN NF2 CALM3;CALM1 MYL12B MYLK PAK1 CDC42 PAK3 MYH11 PAK2 MYH9 LIMK1 PPP1CB MYH14 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle RHOBTB3 RAB9A HGS RAB9B VHL CCNE1 CUL3 LRRC41 PLIN3 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF3 FGF4 FGF6 FGF9 FGF20 FGF23 FGF22 PLCG1 FGF1 FGF2 FGF10 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL LCLAT1 PLA2G4A PLA2G6 TAZ HADHA HADHB-1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes JAK1 KPNA7 KPNA5 USP18;USP41 DUS2 KPNA2 KPNA3 UBE2E1 STAT1 STAT3 FLNA CDK1 KPNB1 EIF4G3 IFIT1 EIF4G2 KPNA4-1 EIF4E3 NEDD4 ILF3 EIF2AK2 FAAP100 ISG15 PDE12 PIM1 MX1-1 DHX9 FNTA RNASEL FAAP24 LOC105377022;FANCB PGGT1B FLNB NUP107 GBP2;GBP3;GBP1 HSPA1L ILF2 MAPK3 GBP5-1 DNAJC3-1 PPP2R1B PPP2R1A FANCM FANCL FANCA HSPA2 FANCE FANCG NPM1-2 FANCF FNTB;CHURC1-FNTB UBA7 PPM1B ADAR OASL CENPS-CORT;CORT;CENPS SFN ACTG1 OAS1 NCK1 OAS3 NUP160 EIF4E2 NUP85 SNCA MAP2K6 PPP2CB;PPP2CA SEC13 NUP133 PPP2R5A FURIN EIF4A3 BECN1 NUP43 IKBKB EIF4E CENPX IKBKG RANBP2 CHUK EIF4G1 PLCG1 UBA52 PTPN2 NUP37 SPHK1 PRKRA RPS27A UBB;UBC TARBP2 TP53 HSPA8 ABCE1 UBE2I ACTB-1 SUMO1 IRF3 CASP1 DDX58 NUP205 PIN1 NUP188 AAAS MAVS TRIM25 NUP42 NUP62 TPR NUP88 RAE1 KPNA1 EIF2S2 ARIH1 NDC1 EIF2S3;EIF2S3B NUP214 NUP210 EIF2S1 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 EIF4A2 EIF4A1 UBE2L6 HERC5 FANCC GBP7;GBP4 HSPA1A;HSPA1B UBE2N CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism GATM CKB CKMT2 SLC6A8 SLC6A12 SLC6A7 CKMT1A;CKMT1B SLC6A11 GAMT CKM ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling GNB1 GNB4 GNB3 GNB5 FOS H2AJ AGO3;AGO1 KPNA2 TGFA PPP5C H2BC5 HDAC1 H2BC1 FOSB GNAT3 H2AC4 CAV1 SRC CDKN1B CCND1 CITED1 FOXA1 KDM1A PRMT1 TLE3 FKBP4 NRAS DDX5 PTK2 POU2F1 GREB1 MAPK1 CHD1 H2BC21 CTSD HRAS NCOA3 MAPK3 SMC3 HSP90AA1 NR5A2 TFF1 KANK1 PDPK1 PTGES3-1 H2AZ2;H2AZ1 CXXC5 S1PR3 TFF3-1 KCTD6 PIK3CA KDM4B GNAI3 USF2 USF1 HSP90AB1 ZNF217 GATA3 EBAG9 CXCL12 GNAI1 GNAI2 STRN ESR2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ATF2 TNRC6A-1 CBFB RAD21 TNRC6C RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 STAG1 TNRC6B STAG2 CCNT1 XPO1 NRIP1 EP300 MYB TBP MMP2 GTF2A1 NCOA1 GTF2A2 MED1 SMC1A NCOA2 CREBBP CDK9 CARM1 EGFR CALM3;CALM1 ZDHHC7 ZDHHC21 PPID JUN CAV2 MMP7 EGF ELK1 FOXO3 BCL2 UHMK1 EREG AREG BTC EPGN HBEGF YY1 SPHK1 KAT2B GNGT1 POLR2A POLR2B POLR2C POLR2D GPAM SP1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L ESR1 GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 PRKCZ H2AC14 PGR AKT2 MYC AKT3 AKT1 KAT5 GNG10 IGF1R GNG2 GNG5 FKBP5 GNG4 GNG8 PIK3R3 PIK3R2 PIK3R1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MMP3 NOS3 JUND MOV10 SRF AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 MMP9 GNG13 GNB2 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB NGFR SQSTM1 RELA IKBKB NGF PRKCI RIPK2 RPS27A MYD88 UBB;UBC NFKB1 IRAK1 NFKBIA TRAF6 UBA52 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase COMT MAOA EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs CLIP1 CDH1 RAC1 CTNNB1 CALM3;CALM1 CDC42 IQGAP2 MEN1 CTNNA1 IQGAP1 IQGAP3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2R2A;PPP2R2D ARPP19 CDK1 ENSA PPP2R1B PPP2R1A PPP2CB;PPP2CA MASTL CCNB1 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria PMAIP1 TP53 E2F1 TFDP1 TFDP2 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants KIT TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A TFAP2C MYC CDKN1A KDM5B PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors CHRND CHRNG CHRNE CHRNB2 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 CHRNA2-1 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants AXIN1 AMER1 PPP2R1B CSNK1A1 PPP2R1A PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C GSK3B APC CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly CALM3;CALM1 CASP5;CASP4 SERPINB1 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD MMACHC MMADHC HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism HS3ST4 HS3ST1 HPSE2 HS3ST2 HS6ST1 HS6ST2 HS6ST3 NDST2 HPSE NDST1 NDST4 NDST3 GLCE EXTL2 SGSH GPC1 IDUA HS2ST1 HSPG2 GPC3 HS3ST3A1 GPC2 SDC4 GPC5 SDC2 GPC4 SLC35D2 EXTL3 SDC3 GPC6 HS3ST3B1 AGRN CTSV;CTSL NAGLU IDS EXT1 EXT2 SDC1 HS3ST5 HS3ST6 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 HBA2;HBA1 NCOR1 TBL1XR1 CARM1 MAFK NFE2L2 SIN3A STAT3 COX7B FABP1 COX7C COX8A NCOR2 COX8C COX5B COX5A COX6C NLRP3 ALB COX7A2L-1 HMOX2 COX6A1 COX6A2 STAP2 COX6B2 COX6B1 TXNIP RXRA COX7A2 BLVRB PPARA BLVRA HM13 COX4I1 COX4I2 SMARCD3 HDAC3 CHD9 PTK6 ABCC1 HBD;HBB BACH1 CYCS-1 HELZ2 TGS1 HMOX1 NCOA1 MED1 NCOA2 NDUFA4 CREBBP NCOA6 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis CASP8 FADD RIPK3 TRAF2 RIPK1 MLKL TRADD PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling RAC1 SALL4 VAV1 IL33 CSNK2A1;CSNK2A3 AGO3;AGO1 HDAC5 IL1RL1 RICTOR HDAC2 SUZ12 KIT HDAC1 HDAC7 FLT3LG CD86 CD80 MTA1 PML MTA3 SNAI2 NEDD4 SRC INSR THEM4 MET EGR1 INS;INS-IGF2 GSK3A PRR5 GSK3B PIK3CD PIK3CB MAPK1 PIK3CG PDGFB CD19 MAPK3 MLST8 EED FRS2 PDPK1 PIK3CA IER3 LCK PHLPP2 PHLPP1 ATN1 MAF1 RPS6KB2 RBBP4 PIP5K1C STRN ESR2 NR4A1 FYN RBBP7 ATF2 TNRC6A-1 PTPN11 NR2E1 MTOR TNRC6C HDAC3 TNRC6B MKRN1 ERBB2 NRG2 NRG3 NRG4 RPTOR TSC2 RRAGA RRAGC RRAGB RRAGD EGFR AKT1S1 SLC38A9 MBD3 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 GATAD2B GATAD2A JUN FOXO3 TP53 FOXO4 HGF PTEN XIAP RHOG STUB1 PDGFRA PDGFRB TRAT1 NTRK3 PIK3AP1 TGFA CDKN1A CDKN1B FOXO1-1 SNAI1 KDM1A FLT3 PPP2R1B PPP2R1A RCOR1 IRAK1 PREX2 MDM2-2 CHD4 TRIM27 CHD3 USP13 TNKS TNKS2 WWP2 RNF146 CBX8 FRK CBX6 PHC2 OTUD3 PHC1 PPP2CB;PPP2CA CBX4 MTA2 CBX2 PPP2R5E REST PHC3 SGK1-1 PPP2R5B PPP2R5A PPP2R5D PIP4K2A BMI1 PPP2R5C PIP4K2B RING1 RNF2 PIP5K1A PIP5K1B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 NTRK2 BDNF CHUK BAD GAB1 CASP9 PSMC2-1 PSMA5 NTF4 PSMA6 PSMA3 NTF3 PSMA4 PSMA1 EGF UBA52 EREG AREG PSMD12 BTC PSMD11 EPGN PSMD14 HBEGF PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 MECOM SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NRG1 ESR1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 PPARG FGF7 FGF9 AKT2 FGF20 FGF23 AKT3 FGF22 AKT1 GAB2 USP7 FGF16 CSNK2A2 FGF19 FGF18 CSNK2B TRIB3 FGFR4 FGF10 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 MYD88 MOV10 AGO4 AGO2 CD28 EZH2 TRAF6 IRAK4 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation PSMD8 IKBKB PPP3CA PSMD6 PPP3CB PSMD7 PSMD2 VAV1 PPIA PSMD3 RASGRP1 PSMD1 RASGRP3 IKBKG PPP3R1 BTRC NFATC3 MAP3K7 NFATC2 SKP1 NFATC1 CHUK CALM3;CALM1 PIK3AP1 PRKCB FKBP1A FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 AHCYL1 MALT1 CD22 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 SH3KBP1 PSMB3 PSMB1 RPS27A BTK UBB;UBC ADRM1 NFKB1 PSMA2-1 SEM1 NFKBIA STIM1 PSMC5 ORAI2 PSMC6 ORAI1 PSMC3 PLCG2 PSMC4 PSMC1 REL NFKBIE BLNK ITPR1 NFKBIB ITPR2 NRAS TRPC1 ITPR3 PIK3CD HRAS CD19 CD79B SYK CD79A SOS1 NCK1 FYN BLK DAPP1 PIK3R1 PTPN6 LYN GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA PIWIL2 PIWIL1 PIWIL4 DDX4 HENMT1 ASZ1 MAEL TDRKH-1 H2AJ MOV10L1 MYBL1 AGO3;AGO1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 BCDIN3D XPO5 DROSHA H2BC5 H2BC1 H2AC4 TSNAX PRKRA DICER1 TARBP2 TSN POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G H2BC21 POLR2H POLR2I HSP90AA1 POLR2L H2AZ2;H2AZ1 POLR2J;POLR2J2;POLR2J3 PLD6 H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RAN TNRC6A-1 DGCR8 ANG TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 IPO8 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer CDC37 HRAS HSP90AA1 PIK3R1 EGFR PIK3CA RPS27A UBB;UBC CBL GAB1 SOS1 SHC1-1 PLCG1 EGF UBA52 NRAS FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation FGF1 FGF2 FGF3 TGFBR3 FGF4 FGF6 ANOS1-1 GIPC1 FGF9 FGF20 FGF23 FGF22 FGF10 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CDKN2A ATM PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CDKN1A RPS27A CDKN1B UBB;UBC ADRM1 PSMA2-1 TP53 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CCNE2 CCNE1 CDK2 MDM2-2 PHF20 CHEK2 ZNF385A COP1 PCBP4 MDM4 CCNA2-1 CCNA1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis BIRC7 BCL2A1 TNRC6C HINT1 TNRC6B SIN3A DICER1 AGO3;AGO1 TRPM1 MOV10 AGO4 AGO2 POU3F2 BCL2 HDAC1 TNRC6A-1 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA ABAT ALDH5A1 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels BEST3 SLC9C2 BEST1 BEST4 NEDD4L SLC9B1 SLC9B2 SCNN1G CLCA4-1 SCNN1D RAF1 SCNN1B SCNN1A TTYH3 TTYH2 WNK4 NALCN ASIC4 CALM3;CALM1 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 ASIC1 UBA52 WNK1 WNK3 UNC80 RYR1 CLCNKA;CLCNKB RYR2 CLCN6 TSC22D3 ANO8 ANO9 RYR3 ANO6 ANO4 ANO5 ANO2 ANO3 RPS27A CLIC2 ANO1 UBB;UBC STOML3 STOM TRPM1 TRPM2 TRDN TRPM7 ASPH TRPM8 TRPM5 CLCN3 TRPM6 CLCN2 TRPM3 CLCN1 TRPM4 TRPC7 BSND TRPC5 ANO10 SGK3;C8orf44-SGK3 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TPCN2 TRPC1 TPCN1 SRI TRPV2 CLCN7 TRPV3 CLCN5 WWP1 TRPV1 CLCN4 MCOLN1 OSTM1 TRPC4AP MCOLN2 TRPV6 TRPV4 UNC79 TRPV5 FKBP1B SGK1-1 BEST2 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling MBTPS2 LIPC CREB3L3 LIPG APOA2 APOA4 APOE APOA5 ANGPTL8 ANGPTL3 ANGPTL4 ABCG1 CETP MTTP LCAT LPL LMF2 LMF1 APOF FGF21 GPIHBP1 FURIN APOB PCSK6 APOC3 PCSK5 MBTPS1 APOC2 ALB APOA1 P4HB ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides DEFB125 DEFB1 DEFB123 DEFB121 DEFB109B DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 DEFB114 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB110 DEFB130B;DEFB130A DEFB105A;DEFB105B CCR6 DEFB103A;DEFB103B DEFB4A;DEFB4B CCR2 LYZ-1 ATP7A SLC11A1 BPIFB2 PGLYRP1 RNASE3;RNASE2-2 ART1 DEFA6;DEFA4;DEFA5 PRSS3;PRSS2;PRSS1 CLU S100A9 CTSG S100A8 TLR1 LCN2 TLR2 PGLYRP4 PGLYRP3 BPI PGLYRP2 PLA2G2A-1 LEAP2 ATOX1 LTF S100A7A;S100A7 CD4 EPPIN;EPPIN-WFDC6 CAMP RNASE6 RNASE7 ITLN2;ITLN1-2 BPIFA1 REG3G;REG3A-1 PDZD11 ELANE BPIFB1 BPIFB4 BPIFB6 CHGA DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane FRAT2 AMER1 PPP2R1B PPP2R1A CSNK1A1 CSNK1G2 WNT8A WNT8B LRP5 APC LRP6 WNT1 AXIN1 FZD1 PPP2CB;PPP2CA FZD2 CAV1 PPP2R5E FZD5 WNT3A CTNNB1 PPP2R5B PPP2R5A DVL1 PPP2R5D PPP2R5C DVL2 DVL3 GSK3B APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response MAPK1 MAPK3 APAF1 XIAP CYCS-1 APIP CDKN2A BAK1 CASP7 GSDMD CASP3 CASP9 AVEN C1QBP DIABLO-1 UACA BAX GSDME TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis POLD2 TERF2IP RPA1 RPA2 RPA3 TERF1-1 TINF2 DSCC1 RFC5 RFC3 CTC1 RFC4 CHTF18 RFC1 STN1 ACD FEN1 RFC2 TEN1 LIG1 DNA2 BLM PCNA PRIM2 POLD3 PRIM1 POLD4 WRN POLA1 POLA2 TERF2 POLD1 POT1 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection RPS15 RPS14 RPS17 RPS16 YWHAH RPS19 RPS18 IRAK2 ST6GALNAC2 PRKCSH HNRNPA1-1 KPNA2 RPS11 GANAB RPS10 YWHAZ TRAF3 RPS13 IKBKE RPS12 ST3GAL4 RPS9 MGAT1 RPS7 ST3GAL1 RPS8 ST3GAL2 ST3GAL3 TLR7 ST6GAL1 RPS5 VCP-1 RPS6 MOGS RPSA PYCARD RCAN3 ST6GALNAC3 KPNB1 ST6GALNAC4 RB1 CAV1 RPS25 RPS29 RPS20 RPS21 RPS24 NLRP3 RPS23 GSK3A YWHAB PARP6 PARP4 GSK3B GALNT1 DDX5 PARP16 RPS4X PARP9 STING1 PARP14 NMI PARP8 PARP10 TOMM70 YWHAG RPS3A PDPK1 CANX RPS27L RPS15A RPS3 NPM1-2 SMAD2;SMAD3 RPS2 SMAD4 SFN FAU RUNX1 YWHAQ CTSV;CTSL RPS27 EP300 BECN1 MAP1LC3B2;MAP1LC3B-1 UVRAG PPIA FKBP1A YWHAE TMPRSS2 VHL ACE2 UBA52 BCL2L1 EEF1A1 RELA RPS27A UBB;UBC NFKB1 NFKBIA PSMC6 TKFC SP1 UBE2I ZCRB1 MPP5 PIK3R4 TBK1 SUMO1 IRF3 CASP1 DDX58 IFIH1 PCBP2 SIKE1 MAVS RIPK3 TRIM25 BST2 PIK3C3 CHMP4C CHMP4B SFTPD CHMP3 CHMP4A CHMP6 CHMP7 PPIH PPIG PPIB ITCH CHMP2B CHMP2A TRAF6 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAQ YWHAE AKT2 SFN YWHAG AKT3 YWHAZ PDPK1 AKT1 YWHAH YWHAB CAV1 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h ALG8 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA HNRNPU PAPOLG RBM7 DDX41 DHX9 TCERG1 SNRPC SNRPA PPP1R8;STX12 HTATSF1 RBM25 PPP1R10 SNRNP70 PRPF40A TUT1 SRSF10 SRSF12 TRA2B RBM39 RBBP6 CPSF7 YBX1 HNRNPC RBMX NCBP1 ACIN1 NCBP2-1 EIF4E XRN2 PPIL2 PQBP1 ZNF830 SRRT ZCRB1 SNRNP200 FUS BCAS2 CTNNBL1 PRCC HNRNPA3 GPKOW CDC5L CCAR1 NUP205 PCBP1 NUP188 PCBP2 AAAS RBM10 NUP42 NUP62 TPR SUGP1 NUP88 DHX15 RAE1 DHX16 NDC1 FIP1L1 NUP214 NUP210 NUP155 NUP153 NUP93 HNRNPA2B1 NUP50 POM121;POM121C WBP11 NUP35 NUP54 PPIE PPIH PPIG DDX46 DDX42 RBM17 PDCD7 BUD31 SNRNP35 SNRNP25 RBM22 DDX23 ZRSR2-1 RNPC3 ZMAT5 SMNDC1 SNRNP48 U2SURP HNRNPR HNRNPL METTL14 HNRNPM METTL3 HNRNPK HNRNPF HNRNPD WTAP GPATCH1 PNN HNRNPA1-1 CXorf56-1 SF3B4 SF1 SF3B5 DHX8 PRKRIP1 SF3B2 CWF19L2 SF3B3 WDR70 ISY1;ISY1-RAB43 DHX35 SF3B6 PRPF38A SF3B1 SMU1 SF3A3 NKAP UBL5 SF3A1 GCFC2 SF3A2 PRPF18 XAB2 SDE2 PHF5A FAM32A PPP1CB CACTIN PRPF31 RBMX2 TXNL4A SNIP1 SNRPN SNW1 IK PRPF4B CHERP LENG1 LSM5 PPP1CA PRPF4 LSM4 PRPF3 SNRNP27 LSM3 ZMAT2 LSM2 CCDC12 YJU2 CPSF4 LSM8 LSM7 LSM6 NSRP1-1 PTBP1 PPWD1 USP39 PLRG1 SART1 TFIP11 SNRPA1 SYF2 DNAJC8 LUC7L3 C9orf78 PUF60 WBP4 SNRPB2 RNF113A MFAP1 SNRNP40 RBM42 BUD13 FAM50A PPIL3 PPIL4 SRRM2 DDX5 AQR CRNKL1 NUP107 PRPF19 HNRNPH1 HNRNPH2 SAP18 CWC25 CPSF2-1 PPIL1-1 CWC27 CPSF1 CSTF3 EFTUD2 CWC22 CPSF3 CSTF2 PRPF6 CSTF2T WDR33 PRPF8 NUDT21 PABPN1-1 CLP1 PCF11 CWC15 PAPOLA NUP160 SYMPK RBM5 NUP85 SEC13 NUP133 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 GLE1 NXF2;NXF2B;NXF5-1 THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 NUP43 SRRM1 SLBP DDX39A DDX39B SARNP ZC3H11A SRSF2 RANBP2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A POLDIP3 SRSF1 NXF1 U2AF2 FYTTD1-1 DHX38 UBA52 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NUP37 RPS27A UBB;UBC SNRPD2 SNRPD1 SNRPD3 HSPA8 SNRPF POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 MTREX SNU13 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation PIK3CD PIK3CB PIK3CG PIK3R3 PIK3R2 LOC102723996;ICOSLG PIK3R1 PIK3R6 PIK3R5 PIK3CA ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 FGF1 FGF2 FGF3 FGF4 FGFR2 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib CDC37 HSP90AA1 ERBIN ERBB2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex SOX3 WDR5 SOX6 SOX7 SOX4 CTNNBIP1 SOX9 SOX13 CTBP1 PYGO1 BTRC PYGO2 LEF1 BCL9L TLE1 BCL9 AKT2 CHD8 MEN1 RBBP5 YWHAZ CBY1 SOX17 AKT1 UBA52 TCF7L2 HDAC1 TCF7L1 APC SOX2 SRY XIAP RPS27A UBB;UBC TCF7 XPO1 CTNNB1 TLE4 TLE2 ASH2L TLE3 KMT2B DPY30 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L NCBP2-1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 NELFB NELFA NELFCD NELFE NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CTDP1 CCNH POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing C9orf64 TRDMT1 PUS3 OSGEPL1 TRMT10A TYW5 GTPBP3 METTL1 TRMU YRDC NSUN2 TYW3 MTO1 TPRKB ADAT1 CDKAL1 TRMT1 NSUN6 PUS7 FTSJ1 TRIT1 ADAT3 ADAT2 DUS2 QTRT1 TRMT9B QTRT2 CTU2 CTU1 RPP14 TYW1;TYW1B TRMT5 TRMT6 TRMT12 TRMT13 TRMT11 TRMT61A TP53RK EPRS1 CPSF4 NUP107 CPSF1 CSTF2 CLP1 NUP160 RAN NUP85 TRMT10C PRORP HSD17B10 SEC13 NUP133 POP5 POP7 POP1 TSEN15 NUP43 POP4 RTCB ZBTB8OS TSEN2 TSEN54 TSEN34 DDX1 RANBP2 C2orf49 RTRAF XPOT FAM98B NUP37 TRNT1 TRMT112 RPP30 NUP205 NUP188 AAAS RPP38 NUP42 NUP62 TRMT61B TPR NUP88 RAE1 NDC1 NUP214 RPP21 NUP210 RPP25 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 RPP40 URM1 WDR4 THADA LAGE3 OSGEP THG1L ALKBH8 LCMT2 TRMT44 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence RNF2 MAPK9 MAPK8 MAP4K4 FOS CDKN2D CDKN2B IFNB1-4 H2AJ CDKN2C CDKN2A MAPK10 AGO3;AGO1 JUN SUZ12 UBA52 H2BC5 H2BC1 H2AC4 RPS27A UBB;UBC TP53 E2F1 E2F2 E2F3 TFDP1 CDK6 TFDP2 CDK4 MAPK1 H2BC21 MAPK3 EED H2AZ2;H2AZ1 MAPK14 MAPK11 MAPKAPK3 MAPKAPK2 H2AC14 RBBP4 MAP3K5 MAP2K3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MAP2K4 RBBP7 MAPKAPK5 TNIK TNRC6A-1 MDM2-2 TXN TNRC6C MAP2K7 H2BC15;H2BC3;H2BC11;H2BC12 MAP2K6 CBX8 CBX6 TNRC6B PHC2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PHC1 CBX4 CBX2 PHC3 MOV10 AGO4 H2AC20 MDM4 H2AB2;H2AB3;H2AB1 EZH2 BMI1 KDM6B RING1 MINK1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels SRI CALM3;CALM1 ATP2A3 ATP2B4 ATP2A2 ATP2B3 ATP2A1 ATP2B2 SLC8A1 ATP2B1 SLC8A2 SLC8A3 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors GPR17 LTB4R CYSLTR1 CYSLTR2 LTB4R2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC31A ATG14 BECN1 SEC24C CANX SEC23A PIK3R4 ERAP2 SAR1B ERAP1 SEC13 PDIA3 SEC24B TAP2 SEC24A TAP1 TAPBP CALR-1 B2M SEC24D-1 PIK3C3 HSPA5 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np HHAT DHH IHH SHH PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis POMC PCSK1 INHA FSHB CGA TSHB INHBB INHBC INHBA INHBE LHB DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling PIK3CB RAC1 VAV2 HRAS SYK PIK3CA LCK SOS1 KLRC4;KLRC3;KLRC2;KLRC1 TYROBP PLCG1 FYN B2M HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KLRD1 PIK3R2 PIK3R1 GRAP2 BTK PLCG2 KLRC4-KLRK1;KLRK1 VAV3 LCP2 TREM2 NRAS FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation FGF4 FGF6 FGF9 FGF20 FGF23 FGF16 FGF18 FGF1 FGF2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism CYP27A1 HSD3B7 AKR1D1 OSBP NR1H4 CYP7B1 CYP7A1 RXRA ABCC3 ACOT8 HSD17B4 CYP8B1 BAAT SLC27A2 ACOX2 CYP46A1 CYP39A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FABP6 SLCO1A2 STARD5 SLC10A1 SLC10A2 AMACR ABCB11 SLC51A SLC51B CH25H SLC27A5 OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL1A NCOA1 OSBPL2 NCOA2 ALB PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing POGLUT1 POFUT1 MFNG SIRT6 RFNG ELF3 H2AJ AGO3;AGO1 JUN ST3GAL4 H2BC5 ST3GAL3 H2BC1 SNW1 ATP2A3 ATP2A2 ATP2A1 H2AC4 KAT2B KAT2A NOTCH1 SEL1L CCND1 TP53 E2F1 E2F3 TFDP1 TFDP2 RBPJ MAMLD1 H2BC21 TMED2-1 H2AZ2;H2AZ1 B4GALT1 LFNG H2AC14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TNRC6A-1 RAB6A TNRC6C RUNX1 NOTCH2 ST3GAL6 H2BC15;H2BC3;H2BC11;H2BC12 NOTCH3 TNRC6B NOTCH4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PRKCI MAML2 MOV10 MAML1 ELANE AGO4 EP300 H2AC20 AGO2 FURIN H2AB2;H2AB3;H2AB1 CREBBP INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade GNB1 PPEF1 METAP2 GUCY2D PRKCA PDE6B PDE6A FNTB;CHURC1-FNTB CALM3;CALM1 CAMKMT RGS9BP NMT1 LOC118142757;GUCA1A GRK1 GRK7 SAG CNGA1 NMT2 RHO GUCA1C GNAT1 CNGB1 RCVRN PRKCQ FNTA GNGT1 METAP1 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle CCR5 CXCR4 CD4 FEN1 PPIA LIG1 LIG4 XRCC4 PSIP1 BANF1 XRCC6 XRCC5 KPNA1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA PPIA DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 FMOD OMD PRELP ACAN OGN LUM CHST6 KERA CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling MAPK1 HRAS CAMK2G MAPK3 DLG1 RPS6KA1 DLG3 PDPK1 DLG4 CALM3;CALM1 GRIN2B RPS6KA3 RPS6KA2 RPS6KA6 ACTN2 GRIN1 GRIN2D DLG2 RASGRF2 RASGRF1 NEFL CAMK2B CAMK2D CAMK2A NRAS MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis ATP5MC3 MICOS13 HCFC1 MICOS10 NCOR1 TBL1XR1 ATP5MC1 APOO CARM1 ATP5F1A SIRT4 ATP5F1B CHCHD3 SAMM50 CHCHD6 ATP5MJ ATP5MG ATP5ME DMAC2L HSPA9 ATP5PF ATP5PD APOOL MTX1 CALM3;CALM1 ATP5PB MTX2 DNAJC11 IMMT ATP5F1C ATP5F1D TMEM11 SOD2 ATP5PO ACSS2 IDH2 CAMK4 NRF1 MAPK14 MAPK12 RXRA MAPK11 PRKAA2 TFAM-1 ALAS1 TFB2M PPARA PPARGC1B PRKAB2 GABPA SIRT5 PRKAB1 PPRC1 GLUD1;GLUD2 PERM1 ATF2 CRTC2 TFB1M SMARCD3 CRTC3 HDAC3 CHD9 CRTC1 POLRMT POLG2 CYCS-1 HELZ2 TWNK TGS1 SSBP1 ESRRA PPARGC1A MEF2D PRKAG1 MTERF1-1 NCOA1 PRKAG2 MED1 NCOA2 MEF2C SIRT3 CREBBP NCOA6 PRKAG3 ATP5MC2 NR1D1 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade FLT3 PIK3CB PDPK1 FRS2 KLB IRS1 PDE3B PIK3CA PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 GAB1 FGF9 AKT2 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 FGF10 PTPN11 FLT3LG PIK3R2 PIK3R1 THEM4 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ILK PARVA PXN ITGB1 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis PARP1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD TBXAS1 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling NTN4 RAC1 ABLIM1 WASL ABLIM2 ABLIM3 RGMB RGMA SLIT2 SIAH2 SIAH1 ROBO1 DSCAM CDC42 PLCG1 NCK1 MYO10 DCC HJV PTPN11 TRIO NEO1 NTN1 SLIT1 SLIT3 SRC PITPNA UNC5C UNC5D EZR AGAP2 UNC5A UNC5B DSCAML1 TRPC7 TRPC5 PRKCQ TRPC6 DOCK1 TRPC3 TRPC4 TRPC1 PTK2 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 E2F4-1 MYBL2 CDK1 LIN54 LIN52 LIN37 RBL2 LIN9 RBL1 E2F1 E2F5 RBBP4 TFDP1 CCNA2-1 TFDP2 HDAC1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin RAD21 WAPL SMC3 NIPBL STAG1 STAG2 PDS5B SMC1A PDS5A MAU2 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC4A10 SLC12A2 SLC4A8 SLC26A7 SLC12A3 SLC4A9 SLC12A4 SLC26A9 SLC12A5 SLC26A6 SLC12A1 SLC12A6 SLC12A7 SLC13A1 SLC13A4 AHCYL2 SLC4A4 SLC34A2 SLC34A1 SLC4A7 SLC26A4 SLC26A3 SLC4A2 SLC26A11 SLC4A3 SLC4A1 SLC4A5 SLC5A8 SLC20A2 SLC5A5 SLC26A2 SLC20A1 SLC26A1 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events PDE1C PDE1B PDE1A GRK2 PRKCD PLA2G4A POMC SRC CAMK4 C5AR1 MCHR1 MAPK1 NPY GNAT2 PRKCA PLCB3 PLCB1 PLCB2 PRKAR1A OPRM1 OPRK1 SSTR3 PPP3CA PPP3CB PPP3R1 RXFP4 CALM3;CALM1 RLN3 APP INSL5 RXFP3 RGS9 RGS6 RGS7 CCR5 CDK5 GNA14 GNA15 GNGT1 GNA11 PDYN AGTR2 FPR1 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 GNAS-1 GPR37 CXCL2;CXCL3;CXCL1-1 RGR GNAQ RGS11 CCL4L2;CCL4L1;CCL4 CCL19 OPN1SW CCL16 CCL25 P2RY12 P2RY13 GNG10 CCL21 CX3CR1 CCL20 P2RY14 GPR55 GNG2 CCL28 GNG5 CCL27 GNG4 GNG8 CXCL13 ADORA3 ADORA1 MTNR1A MTNR1B PSAP CXCL10 CXCL11 CHRM2 CHRM4 P2RY4 CCL5 CCL1 APLN RRH TAS2R3-1 CXCL5;CXCL6 TAS2R16 GPR37L1 TAS2R40 GNG13 HRH4 TAS2R41 GNB2 TAS2R42 DRD3 SST DRD4 GNB1 GNB4 PENK GNB3 PPY HTR1E GNB5 CCR10 HTR1F CCR1 PPBP TAS2R39 HTR1D HCAR2;HCAR3 ACKR3-2 PTGDR2 HTR1B NPY4R2;NPY4R CX3CL1 HTR5A CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 KPNA2 OXGR1 GAL OPN1MW3;OPN1MW2;OPN1MW;OPN1LW OPRD1 NPB PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 AHCYL1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PPP1CA GNAT3 C3AR1 NPY2R NPY1R PRH1-TAS2R14;TAS2R14-3 ADCY9 PRKACA-1 APLNR PRKAR1B PRKACB-1 SUCNR1 HCAR1 OPN3 OPN5 GNAZ PYY TAS2R7 CXCL9 TAS2R8 PRKAR2B GRM3 HEBP1 GRM2 CAMK2B GRM4 CAMK2D GRM7 CAMK2A GRM6 ANXA1 ITPR1 GPER1 ITPR2 GRM8 TAS2R1 TAS2R4 ITPR3 NPY5R SSTR1 SSTR2 SSTR4 CAMK2G SSTR5 OPRL1 CNR2 CNR1 TAS1R2 PPP2R1B S1PR3 PPP2R1A TAS1R1 ADCY4 S1PR2 PRKAR2A GNAI3 S1PR5 S1PR4 ADCY3 TAS1R3 PPP1R1B PRKX ADCY2 CXCL12 ADCY1 RGS8 ADCY8 ADCY7 GNAI1 PCP2 ADCY6 CENPS-CORT;CORT;CENPS GNAI2 PDE4D-1 ADCY5 GPSM1 GPSM2 PDE4A GPSM3 PDE4C RGS14 RGS20 RGS22 RGS10 CXCR4 RGS12 PPP3CC PPP2CB;PPP2CA CXCL8 PPP2R5D PLCB4 RGSL1 LPAR1 LPAR2 LPAR3 FPR2 PRKCG GPR17 LPAR5 NMS NMU GNAL NBEA CAMKK1 CAMKK2 CCL13;CCL2 C5 ADRA2C ADRA2B C3-1 AGT ADRA2A PMCH RGS4 GABBR2 RGS5 GABBR1 RGS3 RGS1 CASR PF4;PF4V1-1 MCHR2 KNG1 NMUR2 NMUR1 BDKRB2 BDKRB1 RGS18 RGS17 RGS19 RGS13 RGS16 RHO RGS21 GNAT1 SAA2;SAA1 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription ZCRB1 VHL RB1 DDX5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism MMAB MMACHC MMADHC ABCD4 TCN2 LMBRD1 CBLIF CUBN MMAA AMN CD320 MTRR MMUT MTR-1 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling AIP ARNT2 AHR PTGES3-1 ARNT AHRR HSP90AB1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions DSCAML1 DSCAM NTN1 DCC ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia NMRAL1 ASS1 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO1C1 SLCO4A1 SLCO4C1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO2B1 AVP SLCO1A2 SLCO2A1 SLC16A2 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 MAP2K2;MAP2K1 MAPK1 RAC1 VAV2 MAPK3 EGFR ITGA2B CSNK2A1;CSNK2A3 ITGA5 ITGA9 PAK1 NRP1 NCAM1 ITGB3 CSNK2A2 CSNK2B ITGB1 ITGAV L1CAM FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation FGB F13A1 FGA SERPINE2 FGG SERPINA5 F13B ITGA2B PROC ITGB3 SERPIND1 F2 SERPINC1 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis SIN3A MMP1 F7 PDE1B PDE1A F9 HDAC2 PRKCD YWHAZ PLA2G4A HDAC1 PDPN MPIG6B CFD FCER1G GP6 F10 SRC CAV1 ZFPM1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 VAV3 GTPBP2 ABCC4 SYTL4 CD109 TAGLN2 GP1BA NHLRC2 NRAS CLU RAP1A STXBP3 TEX264 STXBP2 MAPK1 SERPINA1 LY6G6F;LY6G6F-LY6G6D VAV2 PDGFB HRAS ENDOD1 MAPK3 A1BG APOH VTI1B SERPING1 RAB27B MANF MAPK14 CALU MAGED2 HRG F5 FERMT3 SERPINA3 F8 ECM1 OLA1 CTSW ORM2;ORM1 TIMP3 SOS1 QSOX1 CBX5 AHSG CRK ANXA5 DOCK11 SHC1-1 RAPGEF3 RAPGEF4 TOR4A CD63 SPP2 VEGFB VEGFC ACTN1 VEGFD LHFPL2 PCYOX1L MPL F13A1 CFL1 ANGPT1 FAM3C PDE5A TEK SERPINE2 LEFTY2;LEFTY1 SERPINA5 APLP2 THBD TMX3 SMPD1 HBD;HBB TTN-1 CD177 SELENOP PROCR SCG3 F11 IRAG1 THPO DOCK6 F13B PDE9A RARRES2 DOCK9 CYRIB THBS1 SELP SCCPDH LGALS3BP WDR1 PLEK PHACTR2 CLEC1B SRGN APOB MMRN1 PECAM1 ITIH4 ITGB3 ITIH3 PLG CLEC3B ARRB1 CDC37L1 ANGPT4 AAMP ANGPT2 BCAR1 GRB14-1 ARRB2 APOA1 RAP1B JAK2 DGKG DGKE DAGLA FGB DGKD FGA DGKB DGKA MAFK VWF ABHD6 FGG ABHD12 PRKCH APBB1IP PRKCE DGKZ DGKQ GRB7 RAF1 PPIA DAGLB TLN1 RASGRP1 DGKK DGKI VCL DGKH CALM3;CALM1 APP CDK5 RHOB NOS2 PCDH7 GNGT1 HGF TF GNAS-1 GNA13 TBXA2R GNA12 DOCK10 BSG GNG10 IRF2 GNG2 GNG5 GNG4 GNG8 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A RACGAP1 CABLES1 WEE1 SLC16A1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 APOOL DOK2 EPCAM ATP2A3 GNAT3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PRKACA-1 PRKAR1B PRKACB-1 NOS1 A2M ATP1B2 ATP1B1 STIM1 ORAI2 PRKAR2B ORAI1 PLCG2 ITPR1 VPS45 ITPR2 ALB HMG20B ITPR3 CDK2 SRI PHF21A ATP1B3-1 ATP2B4 SYK ATP2B3 PPP2R1B FGR PPP2R1A ATP2B2 ATP2B1 SLC8A3 GNAI3 RCOR1 GNAI1 GNAI2 HSPG2 P2RX7 SDC4 P2RX4 SDC2 SDC3 KIF18A KCNMB1 KCNMA1 PPP2CB;PPP2CA SDC1 PPP2R5E SERPINB2 MIF MFN1 INPP5D MFN2 PPP2R5B PPP2R5A ITPK1 PPP2R5D DOCK7 PPP2R5C KIF2A KIF2C KIF2B IFNB1-4 ALDOA CD44 DOCK3 CENPE GPC1 GPC3 CD9 PLCG1 DOCK8 EGF GPC2 GPC5 GPC4 GPC6 PRKCG AGRN CD36 AKAP1 TSPAN7 LRP8 P2RX6 P2RX5 P2RX3 P2RX2 PICK1 P2RX1 MAFG PLAUR RBSN AKT1 PROS1 SOD1 HSPA5 MERTK PIK3R3 GAS6 PIK3R2 PIK3R1 PIK3R6 PIK3R5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN YES1 SLC3A2 SLC7A11 SLC7A10 SLC16A8 SLC16A3 RAC1 SLC7A5 SLC7A6 SLC7A7 VAV1 SLC7A8 SLC7A9 JCHAIN KIF12 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 ANO6 KIF6 ACTN2 KIF27 ANO5 KIF9 KIFC2 KIFC1 KIFAP3 KIF16B KIF20B ITGAM ITGB2 KIF18B KIF26B HBG2;HBG1 JMJD1C AK3 ITGAX GATA5 MICAL1 CARMIL1 CD47 EHD1 JAM2 EHD2 JAM3 EHD3 PIK3CB MAFF PIK3CG AKAP10 KIF3B SH2B1 KIF3A PRKG2 CABLES2 PRKCA PDPK1 PIK3CA KIF3C LCK GATA4 IRF1 GATA3 GATA2 GATA1 CDC42 PRKAR1A GATA6 FYN CSK PTPN11 PTPN6 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 MAG LAMP2 F3 IGF2 IGF1 PLAT SERPINB8 TUBA4A PLAU SERPINB6-2 S100A10 SPN PPIL2 TP53 GNA14 SERPIND1 GNA15 GNA11 GNAQ F11R PRKCZ RHOA PROC P2RY12 ITGB1 ITGAL DOCK5 DOCK4 RAB5A CYB5R1 ITGA4 PSAP NOS3 ITGA5 KIF20A RHOG KLC1 KLC4 KLC3 KLC2 KIF11 KIF15 PTPN1 DOCK2 DOCK1 KIF23 KIF22 KCNMB2 KCNMB3 PAFAH2 KCNMB4 CD74 KIF26A PPBP CD84 VPREB3 VPREB1 CXADR FCAMR IGLL5;IGLL1 JAML GYPC CD99L2 SIRPA;SIRPB1;SIRPG GLG1 SH2B3 SH2B2 CD99 SELE SELL ESAM TREM1 OLR1 CD48 SERPINC1 SELPLG CD2 CD244 GP9 GP1BB FLNA GP5 GUCY1B1 TGFB1 BRPF3-1 MGLL KIF5B KIF5A GUCY1A2 GUCY1A1 VEGFA KDM1A ITGAV ANXA2 PTK2 PTGIR PFN1 PRKAR2A PDE2A STX4 CAP1 PDE11A CAPZB KIF4B;KIF4A PDE10A CAPZA1 CAPZA2 TIMP1 TGFB2 SERPINE1 MYB ADAMTS13 L1CAM ITGA10 TGFB3 NFE2 PRKCB F12 KLKB1 TRPC7 F2 TRPC6 TRPC3 ADRA2C ADRA2B ADRA2A F2RL2 F2RL3 ITGA2B FN1 F2R PF4;PF4V1-1 KNG1 ITGA3 ITGA2 ITGA1 ZFPM2 ITGA6 ABL1 RAD51B RAD51C P2RY1 PRKCQ LCP2 RASGRP2 LAT DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 GNE CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress RPA1 RPS6KA1 AMER1 RPA2 PALB2 RAD50 SIN3A RPA3 ATM ATR ANAPC15 PRKCD ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 HDAC6 ANAPC11 CDC23 EIF2AK1 UBE2S ATF5 CDC26 CDC16 HSP90B1 TXNRD1 CDC27 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ID1 GRB10 CITED2 COX7A2L-1 GSTA3;GSTA1 MAPK1 MAPK3 MAPK14 HSP90AB1 MAPK11 CUL7 COX7A2 MAPKAPK3 MAPKAPK2 PREB SHC1-1 GOSR2 ATF2 SLC46A1 SEC31A CRTC2 SMARCD3 CRTC3 HDAC3 CHD9 CRTC1 LY96 HBD;HBB ARFGAP1 BACH1 NPAS2 ARNTL HELZ2 RAI1 PGRMC2 HSPD1 XPO1 TGS1 NRIP1 EP300 HMOX1 CLEC1B OMA1 APOB PPARGC1A MEF2D NCOA1 MED1 NCOA2 MEF2C RPTOR CREBBP NCOA6 APOA1 NR1D1 SIRT1 HBA2;HBA1 NCOR1 RRAGA TBL1XR1 MAP1LC3B2;MAP1LC3B-1 RRAGC CARM1 MAFK RRAGB RRAGD TLR4 CLOCK AKT1S1 NFE2L2 SLC38A9 TLN1 RHEB LAMTOR2 STIP1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 YWHAE JUN VHL SOD2 FOXO3 LMNB1 PRDX2 TCIRG1 PRDX1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V1G2 NOTCH1 RBX1 ATP6V1B2 ATP6V0D1 ATP6V0D2 ATP6V0C ADD1 ABCG2 ATP6V1B1 SRPRB-1 ATP6V1A MBTPS1 FKBP14 HYOU1 HERPUD1 MYDGF NFYB NFYC TATDN2 CREB3L4 ATP6V1H CREB3L1 CREB3L2 ATP6V1G3 TSPYL2 ATP6V1D DDX11 HMOX2 SP1 EDEM1-1 ATP6V1C1 NFYA-1 WIPI1 ATP6V1C2 PDIA6 PDIA5 ATP6V1F ERN1 MBTPS2 DCSTAMP CREB3 CTDSP2 ATP6V0E2;ATP6V0E1 KDELR3 ATF6B DCTN1 CEBPG CXXC1 EXTL1 NCF1 SSR1 NCF2 DNAJB9 NCF4 KLHDC3 ZBTB17 WFS1 ASNS YIF1A CREBRF SRPRA HDGF TPP1 EPO IL1A CYBB CA9 HIGD1A UFD1 CYBA DCTN6 DCTN5 DCTN4 PTK6 CAPZA3 ACTR10 CYCS-1 DNAJB11 NPLOC4 CUL3 HSPA9 CREB3L3 BAG2 RB1 CDKN1A CDKN1B FZR1 E2F1 E2F2 E2F3 SKP2 CAMK2B CAMK2D TFDP1 CAMK2A CDK6 DNAJA2 NLRP3 TFDP2 ALB CCNE2 CDK4 P4HB CCNE1 CDK2 IDH1 NUP107 CAMK2G DYNC1LI1 DYNC1LI2 EHMT2 EHMT1 ETS1 TALDO1 ETS2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 MAP2K4 TINF2 NUP160 ERF MAPKAPK5 TNIK ASF1A NUP85 MDM2-2 TXN SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 EP400 IGFBP7 MAP2K7 MAP2K6 CBX8 CBX6 PHC2 ACD RPS27 PHC1 CBX4 CBX2 HMGA2 H1-0 PHC3 H1-3 H1-2 SEC13 H1-5 H1-4 NUP133 IL6 PPP2R5B MDM4 CXCL8 BMI1 CABIN1 CCNA2-1 KDM6B RING1 MINK1 TERF2 CCNA1 POT1 TERF2IP CEBPB DYNC1I2 RNF2 HIRA MAPK9 MAPK8 MAPK7 UBN1 NUP43 MAP4K4 CDKN2D CDKN2B DYNC1I1 TKT IFNB1-4 CDKN2C CDKN2A RANBP2 MAPK10 DYNC1H1 TERF1-1 EXTL2 EGF BCL2 PDGFA AREG EXTL3 BCL2L1 STOML2 EEF1A1 NUP37 PHB2 YME1L1 PGD TXN2 ERO1A AQP8 NUDT2 SESN1 MUL1 ATF4 CCL13;CCL2 ABCF2-H2BE1;ABCF2 DPP3 PRDX3 STAP2 PRDX6 GCLC MAFG NOX5 GCLM SRXN1 CHD6 ME1 UBXN7 ABCC3 GPX1 GPX6 GPX5 GPX8 H2AC14 GPX7 AKT2 BLVRB MYC BLVRA AKT3 HM13 AKT1 GSTP1 NQO1 CSNK2A2 TXNRD2 SOD3 ATOX1 CSNK2B TRIB3 SOD1 ATF3 HSPA5 CCS EIF2S2 EIF2S3;EIF2S3B EPAS1 EIF2S1 HIF1A ABCC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FBXL17 PRKCI MOV10 AGO4 H2AC20 SLC7A11 H2AB2;H2AB3;H2AB1 EZH2 FOS H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 SUZ12 H2BC5 STAT3 H2BC1 VCP-1 LMNA ATP7A H2AC4 ATF6 GSK3A GSK3B HSPA1L H2BC21 MLST8 NRF1 DELE1 EED HTRA2 DNAJA4 H2AZ2;H2AZ1 DDIT3 LONP1 DNAJA1-1 TXNIP HSPA2 PRKAA2 EIF2AK3 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TNRC6A-1 MTOR JMJD7-PLA2G4B;PLA2G4B TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B ACTR1A ELOC-1 ELOB SIRT3 LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP DCTN2 DCTN3 DIS3 PARN EXOSC7 EXOSC6 SESN2 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 SYVN1 EXOSC3 EXOSC2 EXOSC1 HIF3A TP53 NUP205 NUP188 AAAS NUP42 COX4I1 NUP62 TPR COX4I2 NUP88 RAE1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C ARNT NUP35 NUP54 RPL4 RPL30 RPL3 NDUFA4 CALR-1 RPL32 HSPA1A;HSPA1B RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 HSPE1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 COX7B RPL29 FABP1 RPL28 COX7C RPL10;RPL10L-1 COX8A COX8C DCP2-1 RPL3L DEFA6;DEFA4;DEFA5 RPS25 RPL5-1 COX5B RPS29 COX5A RPL27A NOX4 RPS20 RPS21 RPS24 COX6C RPS23 RPL36AL-1 VEGFA RPLP1-2 RPLP0 FKBP4 RPS4X RPL7A RPLP2 COX6A1 RPL36-1 COX6A2 HSP90AA1 RPS3A CUL2 G6PD ACADVL DNAJC3-1 PTGES3-1 RPL13A-1 COX6B2 RPL11 RPS27L COX6B1 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 CAPZB AJUBA CAPZA1 CAT CAPZA2 PPP1R15A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 GFPT1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 HSPB8 HIKESHI PSMD12 CCAR2 PSMD11 HSBP1 PSMD14 DNAJC2 PSMD13 CUL1 DNAJC7 UBE2D3-1 SQSTM1 ST13;LOC107986532 CRYAB RELA PSMA7 RPS19BP1 HSPA4L HSPA14 PSMB6 HSPA13 PSMB7 PSMB4 DNAJB1 PSMB5 BAG4 PSMB2 BAG5 HSPH1 PSMB3 PSMB1 DNAJB6 NCOR2 RPS27A BAG3 HSF1 UBB;UBC BAG1 ADRM1 NFKB1 HSPA4 PSMA2-1 HSPA6 HSPA12A HSPA8 SEM1 HSPA12B PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CHAC1 C12orf66 SZT2 SEH1L NPRL2 NPRL3 RORA GCN1 WDR59 NR3C1 EIF2AK4 ESR1 FLCN MIOS NR3C2 ITFG2 IMPACT DEPDC5 AR KPTN WDR24 RXRA SH3BP4 FNIP1 FNIP2 CASTOR1 CASTOR2 PGR BMT2 PPARA MRE11 IGFBP1 BRCA1 KAT5 NBN FKBP5 KEAP1 UBE2D3;UBE2D2 TRIM21 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type MMAA MMUT EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection ATG7 RICTOR CD14 IKBKE H2BC5 H2AC16;H2AC11 H2BC1 VCP-1 HNRNPU TUSC3 NEK2 H2AC4 C1S TMEM258 MBL2-1 CTNNB1 CGAS ELAVL1 OST4 OSTC STT3A DHX9 C4BPA STT3B C4BPB PRR5 CLU STING1 H2BC21 MLST8 PRKG2 DDOST DAD1 HSP90AB1 UBA7 UBA6 UBA5 UBR4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CPSF7 YBX1 MTOR TSG101 H2BC15;H2BC3;H2BC11;H2BC12 HNRNPC LY96 VIM RBMX UBA3 XPO1 UBA1 FURIN NCBP1 H2BC18 RPTOR APOA1 BECN1 MAP1LC3B2;MAP1LC3B-1 NCBP2-1 TLR4 EIF4E EIF4G1 EXOC1 NMT1 GBF1 ACOT2;ACOT1 SCAP GRPEL1 HYOU1 PQBP1 ATL2 SRRT SNRNP200 FUS NACA BCAS2 CTNNBL1 PRCC HNRNPA0 HNRNPA3 GPKOW CDC5L KDELR1 CCAR1 CD2BP2 IFIH1 PCBP1 PCBP2 PDCD6IP RBM10 MAVS CLEC4M;CD209-2 TRIM25 RETREG1 SUGP1 DHX15 UFD1 DHX16 KPNA1 NCL-1 FIP1L1 PEX19 HNRNPA2B1 WBP11 HNRNPUL1 DNAJB11 PPIE COG1 RIPK1 RTN3 DDX46 DDX42 SUN2 RBM17 DYNLT1 BUD31 MMP9 RBM22 DDX23 RRBP1 SMNDC1 CALR-1 U2SURP HNRNPR HSPA1A;HSPA1B ATG14 BTF3 HNRNPL HNRNPM NPLOC4 HNRNPK HNRNPF HNRNPD HDLBP CLINT1 AP2A1 HNRNPA1-1 KPNA7 AP2A2 SF3B4 SF3B5 KPNA5 SF3B2 KPNA2 SF3B3 ISY1;ISY1-RAB43 KPNA3 SF3B6 SF3B1 AP2M1 SF3A3 DDX3X-1 SF3A1 SF3A2 XAB2 PHF5A AUP1 IPO7 CLEC5A TXNL4A SNRPN SNW1 RPSA BAG2 CHERP P4HA1 P4HA2 P4HA3 KPNB1 EIF4G3 EIF4G2 KPNA4-1 EIF4E3 CPSF4 PTBP1 XRN1 AP2S1 PLRG1 SNRPA1 DNAJC8 PUF60 SNRPB2 SEC11A DAXX CAMK2B SEC11C CAMK2D SNRNP40 AP2B1 CAMK2A DNAJA2 PPIL3 PPIL4 P4HB PPIL6 SRRM2 DDX5 AQR CRNKL1 PRPF19 CAMK2G HSP90AA1 DNAJC3-1 HNRNPH1 CANX HNRNPH2 SPCS3 STAT2 SPCS2 SPCS1 PABPC1;PABPC3 CWC25 CPSF2-1 PPIL1-1 CWC27 CPSF1 CSTF3 RPL18 EFTUD2 CWC22 CPSF3 CSTF2 PDIA3 PRPF6 CSTF2T HSPG2 WDR33 PRPF8 NUDT21 PABPN1-1 CLP1 PCF11 CWC15 PAPOLA DNAJC10 SDC4 SYMPK ELAVL2 SDC2 RBM5 SDC3 SDC1 FASN DPM1 DPM2 U2AF1L5;U2AF1 DPM3 EIF4A3 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 GPC1 TAOK1 SRSF1 GPC3 U2AF2 DHX38 UBA52 GPC2 SRSF11 GPC5 GPC4 SRSF4-1 GPC6 ALYREF RNPS1 AGRN RPS27A UBB;UBC SNRPD2 TAL1 SNRPD1 TJP1 SNRPD3 HSPA8 NFKBIA SNRPF F2 NFKBIB POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 CTR9 UBE2I POLR2F WDR61 POLR2G RTF1 POLR2H CDC73 POLR2I POLR2L LEO1 LOC110384692;C4A;C4B_2;C4B GTF2F1 GTF2F2 PIK3R4 POLR2J;POLR2J2;POLR2J3 SUMO1 H2AC14 PAF1 VTN PROS1 CLDN1 CD33-1 MRC1 EMC4 NRBP1 PIK3C3 HSPA5 TIMD4 RPN2 MERTK MAPKAP1 AXL TYRO3 RPN1 MAPRE3 GAS6 PIK3R1 LY6E H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN H2AC20 EIF4A2 EIF4A1 MAGT1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation DLST AMT DLD AGXT DDO HAO1 GOT2-1 MRPS36 AGXT2 GNMT DAO GLDC GRHPR PXMP2 HOGA1 ALDH4A1 PRODH2 GCSH-3 OGDH SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border BMP4 SOX2 POU5F1;POU5F1B GBX2 ZIC1 WNT3A FGF4 CTNNB1 PAX3 TFAP2A PAX7 MYB TFAP2C MSX1 TFAP2E;TFAP2B DLX5 TCF7L1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions NFASC CNTNAP1 CNTN1 ANK1 NRCAM SDCBP DCX DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP-1 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy ATG14 TOMM40 ATG7 CSNK2A1;CSNK2A3 ATM TOMM7 OPTN-1 HDAC6 MAP1LC3A FUNDC1 USP30 ATG9A VCP-1 ATG12-1 PEX5 ATG5 NBR1 PLIN3 IFT88 MLST8 TOMM70 HSP90AA1 DYNC1LI1 PRKAA1 PRKAA2 DYNC1LI2 MTERF3 MTOR MTMR14 GABARAP MFN1 MFN2 MTMR3 GABARAPL2 RPTOR TSC2 TSC1 DYNC1I2 RRAGA BECN1 MAP1LC3B2;MAP1LC3B-1 RRAGC RRAGB UVRAG RRAGD ULK1 DYNC1I1 SLC38A9 RHEB DYNC1H1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CETN1 PARK7 PLIN2 UBA52 CFTR PCNT SQSTM1 UBE2D3-1 VDAC2-1 VDAC3 RPS27A VDAC1 HSF1 UBB;UBC HSPA8 WIPI1 PIK3R4 TBK1 PRKAB2 CSNK2A2 ARL13B PRKAB1 CSNK2B PIK3C3 CHMP4C CHMP4B EPAS1 CHMP3 TOMM20 CHMP4A TOMM22 CHMP6 CHMP7 PRKN ATG3 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C CHMP2B ATG4B CHMP2A ATG4A ATG4D PRKAG1 WDR45B PRKAG2 AMBRA1 UBE2V1 UBE2D3;UBE2D2 UBE2N PINK1 PRKAG3 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules LRFN3 PTPRD GRIA1 LRFN2 LRFN4 LRFN1 DLG1 DLG3 DLG4 GRIA3 GRIA4 GRIN2C GRIN1 RTN3 GRIN2D GRIN2A FLOT1 GRIN2B FLOT2 PTPRS PTPRF DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism MMAA MMUT RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress GNB1 GNB4 GNB3 GNB5 FLT4 IKBKB TLN1 IKBKG VCL CDH5 CHUK CALM3;CALM1 RICTOR IKBKE STAT1 CAPNS1 RELA CAPNS2 CAPN2 PRKACA-1 ADCY9 PRKAR1B PRKACB-1 NFKB1 CTNNB1 NFKBIA PRKAR2B ADM PKN2 GNGT1 PIEZO1 GNA11 PRR5 ITGAV ANXA2 PTK2 PIK3CD PPP2R2A;PPP2R2D PIK3CB MLST8 TRPV4 PDPK1 GNAS-1 PPP2R1B PPP2R1A PIK3CA ADCY4 PRKAR2A GNAQ ADCY3 RAMP2 ADCY2 CALCRL ADCY1 ADCY8 ADCY7 PRKAR1A ADCY6 ADCY5 AKT1 YAP1-1 FYN GNG10 ITGB1 GNG2 GNG5 MAPKAP1 GNG4 MTOR KDR GNG8 PIK3R2 PPP2CB;PPP2CA NOS3 ABL1 ITGA5 P2RY2 MMP14 PANX1 PECAM1 ITGB3 PTPN1 GNG13 GNB2 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology NCOR1 TBL1XR1 HDAC3 WDR5 PRKACA-1 SIN3A NCOR2 CALM3;CALM1 CAMK4 GPS2 RBBP5 KMT2D ASH2L HDAC1 DPY30 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TAB2 TAB1 MAPK9 MAP2K7 MAPK8 NOD1 NOD2 RIPK2 IRAK2 MAPK10 IKBKG MAP3K7 IRAK1 TRAF6 MAP2K4 UBE2V1 UBE2N TAB3 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines ST20-MTHFS;MTHFS SLC46A1 ALDH1L1 SHMT2 ALDH1L2 MTHFD1 MTHFD2 MTHFD1L MTHFD2L SHMT1 DHFR2;DHFR SLC25A32 FOLR2 SLC19A1 MTHFR DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling SPPL2A TAB2 ARHGEF26 TAB1 SMPD3 RAC1 SMPD2 CLIP3 PSENEN PSEN2 TAX1BP1 NSMAF PSEN1 KALRN APH1A OTULIN RBCK1 NCSTN APH1B VAV1 MCF2 OPTN-1 HDAC2 IKBKE UBE2D1 HDAC1 MIB2 TNF TNFRSF1A VAV3 RNF31 OTUD7B SPATA2 TNFAIP3 SHARPIN VAV2 USP21 USP4 TRAF1 CYLD OTUD1 NGF IRAK1 MAPKAPK2 SOS1 SOS2 CASP2 HDAC3 CASP10 AATF ITGB3BP PRDM4 MAPK8 ULK1 IKBKB LINGO1 MAG OMG RTN4 IKBKG MAP3K7 CHUK BAD YWHAE TIAM1 FASLG UBA52 ARHGEF10L AKAP13 CFLAR ARHGEF11 BCL2L11 NGFR ARHGEF10 SQSTM1 UBE2D3-1 ARHGEF12 RELA ARHGEF17 ARHGEF3 BAG4 ARHGEF1 ARHGEF2 ADAM17 RPS27A UBB;UBC NFKB1 ECT2 MAGED1 RASGRF2 CASP3 NFKBIA NET1 ARHGEF40 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 TIAM2 ARHGEF4 ARHGEF7 NGEF ARHGEF6 FGD1 FGD2 ARHGEF18 FGD3 TBK1 GNA13 TRADD FGD4 CASP8 RHOA ARHGEF33 TNFSF10 ARHGEF37 ARHGEF39 ARHGEF38 BEX3 TRAF2 USP2 TRIO ITSN1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ABR BIRC2 BIRC3 PREX1 XIAP ARHGDIA MCF2L PRKCI RIPK1 RIPK2 MYD88 FADD ARHGEF16 FAS TRAF6 STUB1 ARHGEF5 UBE2D3;UBE2D2 SPPL2B TAB3 RACK1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F9 F10 F8 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA DIS3 EXOSC7 EXOSC6 EXOSC5 ZFP36L1 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 XRN1 EXOSC1 DCP2-1 DCP1A MAPKAPK2 AKT1 YWHAB DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization PML USP7 XIAP UBA52 NEDD4 PTEN RPS27A UBB;UBC FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L NCBP2-1 GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 NELFB NELFA NELFCD NELFE NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CTDP1 CCNH POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RBP3 RBP1 HSD17B6 TTR RPE65 MYO7A HSD17B1 CYP4V2 STRA6 RDH12 RDH8 ABCA4 RHO RLBP1 SDR9C7 LRAT DHRS9 RDH11 RDH10 RBP4 RDH5 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm BMP4 PAX8 LHX1 OSR1 FOXC2 FOXC1 PAX2 FGF2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes HAUS4 PAFAH1B1 HAUS3 DYNC1I2 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CLASP1 DYNC1H1 NDE1 CEP63 YWHAE AKAP9-1 TUBA1A DCTN2 SSNA1 CENPJ DCTN3 PLK1 HAUS8 HAUS7 PCNT OFD1-1 CEP152 CDK1 NEK2 NEDD1 TUBA4A ALMS1 CCP110 PRKACA-1 CEP250 CEP41 CDK5RAP2 CEP43 CEP135 CSNK1D PRKAR2B TUBGCP2 MZT2A;MZT2B TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 TUBG2 NME7 MZT1 HSP90AA1 YWHAG CEP70 TUBB4B CEP72 PPP2R1A CEP192 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E CEP76 CEP78 PLK4 ODF2 CEP57 CETN2 CEP164 ACTR1A MAPRE1-1 CNTRL CDK11A;CDK11B CEP290 CKAP5 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome MAPK1 CASP9 MAPK3 AVEN APAF1 DIABLO-1 UACA XIAP CYCS-1 APIP ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway DUSP6 DUSP7 JAK1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ABHD17B ABHD17A RCE1 KIT FLT3LG MARK3 GOLGA7-1 ZDHHC9 CDK1 ICMT ACTN2 SRC GRIN1 GRIN2D DLG2 NEFL MET SHC2 SHC3 YWHAB NRAS RAP1A MAP2K2;MAP2K1 PIK3CB MAPK1 RALGDS PDGFB HRAS MAPK3 PRKG2 BRAF FRS2 PIK3CA MAPK12 WDR83 RGL3 SOS1 RGL1 RGL2 SHC1-1 PEA15 IL17RD MRAS RAPGEF2 FYN SHOC2 CSK RASGEF1A PTPN11 ANGPT1 TEK ERBB2 NRG2 NRG3 NRG4 ITGB3 ARAF PEBP1 ARRB1 PHB IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG EGFR KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 RASGRP1 RASGRP3 MAP3K11 VCL LAMTOR2 CALM3;CALM1 LAMTOR3 RBX1 ARL2 HGF DLG1 DLG3 DLG4 DUSP10 DUSP5 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PTPN3 PDE6D PTPRA PDGFRA IL2RA SPRED3 ARTN SPRED2 RASA4;RASA4B GFRA3 SPRED1 SYNGAP1 GFRA2 RASA3 GFRA4 RASA1 RASA2 CUL3 PDGFRB RASAL1 RASAL2 RASAL3 DAB2IP NRTN NF1 KBTBD7 TGFA PPP5C PSPN PPP1CB DUSP16 CAMK2B CAMK2D CAMK2A FNTA JAK3 PTK2 FLT3 TYK2 CAMK2G PPP1CC PPP2R1B PPP2R1A FNTB;CHURC1-FNTB IL2 SPTAN1 IL3 SPTB PPP2CB;PPP2CA PPP2R5E IL2RG KRAS SPTBN4 SPTBN5 SPTA1 IL6 PPP2R5B PPP2R5A PPP2R5D NCAM1 PPP2R5C SPTBN1 SPTBN2 IL5RA CSF2RB CSF2RA RANBP9 IL5 IL3RA IL2RB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 GRIN2B PSMC2-1 FRS3 PSMA5 PSMA6 RET PSMA3 PSMA4 PSMA1 EGF UBA52 EREG AREG PSMD12 BTC PSMD11 BCL2L1 PTPN7 EPGN PSMD14 HBEGF PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 RASGRF2 RASGRF1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NRG1 KLB IRS1 CSF2 ITGA2B IRS2 FGF1 FGF2 FGF3 FN1 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF19 FGF18 GFRA1 FGFR4 FGF10 GDNF PIK3R2 PIK3R1 IL6R PRKCQ DUSP4 RASGRP4 LYPLA1-1 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway AMER1 PALB2 NPLOC4 CUL3 CSNK2A1;CSNK2A3 PRKCD VCP-1 TXNRD1 CDKN1A SKP2 GSK3B IDH1 GSTA3;GSTA1 G6PD PRKAA2 TALDO1 EIF2AK3 TXN BACH1 EP300 HMOX1 CREBBP MAP1LC3B2;MAP1LC3B-1 MAFK PSMD8 NFE2L2 PSMD6 PSMD7 PSMD2 TKT PSMD3 PSMD1 CDKN2A BTRC SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF UBA52 BCL2 PDGFA PSMD12 AREG PSMD11 BCL2L1 PSMD14 PSMD13 CUL1 SQSTM1 RELA PSMA7 PRDX1 PSMB6 SESN2 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A PGD UBB;UBC ADRM1 NOTCH1 NFKB1 RBX1 PSMA2-1 SEM1 PSMC5 ABCG2 PSMC6 PSMC3 PSMC4 PSMC1 SESN1 MUL1 ATF4 SP1 CCL13;CCL2 ABCF2-H2BE1;ABCF2 DPP3 GCLC MAFG GCLM SRXN1 CHD6 ME1 UBXN7 ABCC3 AKT2 MYC AKT3 AKT1 BRCA1 NQO1 CSNK2A2 SOD3 CSNK2B UFD1 ABCC1 FBXL17 PRKCI KEAP1 SLC7A11 TRIM21 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA SLC6A12 SLC6A13 SLC6A11 SLC6A1 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD SLC35D1 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle BUB1B-PAK6;PAK6 PAK4 RHOH LCK ROCK1 ROCK2 LAMTOR1 PAK1 VANGL1 UACA TMEM59 PAK2 CSK NIPSNAP2 OSBPL11 TFRC DBT SLC4A7 VCP-1 ARHGDIG PAK5 DBN1 ARHGDIA CAV1 WDR11 ARHGDIB STOM SLC1A5 JUP RALGAPA1 FAM91A1 NSFL1C ZAP70 VAMP3 MTR-1 RAB7A TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling TGFBR3 INHA INHBA ACVR2A PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA H2BC21 EED H2AZ2;H2AZ1 H2AJ H2AC14 RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SUZ12 H2BC5 RBBP7 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC4 EZH1 PHF19 EPOP PHF1 H2AC20 JARID2 H2AB2;H2AB3;H2AB1 DNMT3B MTF2 EZH2 DNMT3A DNMT1 AEBP2 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 ABCA3 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation RAB11B RAB35 RAB7B RAB3B RAB3C RAB3D RAB32 RAB44 RAB31 RAB42 RAB38 RAB2B RAB30 RAB21 RAB36 RAB37 CHML RAB34 CHM RAB4B RAB39A RAB39B RAB18 PTP4A2 RAB11A RAB20 RAB3A RAB25 RAB26 RAB23 RAB24 RAB29 RAB15 RAB19 RAB17 RAB2A RAB27B RAB1A RAB1B RAB5B RAB5C RAB22A RAB6A RAB5A RAB6B RABGGTB RABGGTA RAB9A RAB10 RAB14 RAB13 RAB9B RAB27A RAB8A RAB40C RAB8B RAB4A RAB33A RAB7A RAB33B-1 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells CBFB RUNX1 LGALS3 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UCHL3 UBE2R2 UBE2E3 OTULIN USP9X UBA6 USP5 USP7 UBE2C UBE2E1 UBA52 UBE2D1 UBE2B UBE2H UBE2S UBE2G1 UBE2G2 UBE2W UBE2T RPS27A UBB;UBC UBA1 UBE2K CDC34 UBE2Q2 UBE2Z UBE2D3;UBE2D2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 WNT5A CLTB FZD2 FZD5 ROR1 AP2S1 ROR2 AP2A1 AP2A2 AP2M1 AP2B1 CLTC CLTA ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 VWF ADAMTS13 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport TIMM21 NDUFB8 NDUFA5 HSPA9 LETM1 COX7B COX7C COX8A COX8C SMIM4 UQCC3 UQCRB COX5B UQCC2 COX5A UQCC1 UQCR11 HSCB UQCR10 BCS1L COX6C TTC19 LYRM4 UQCRQ LYRM7 UQCRC1 COX7A2L-1 C12orf73 UQCRFS1 CYC1 UQCRC2 COX6A1 FXN COX6A2 SCO2 COX6B2 COX6B1 COX7A2 ETFB NDUFAB1 SLC25A18 CMC1 MDH1 PYURF MDH2 SCO1 SLC25A12 SLC25A22 SLC25A11 TMEM126B SLC25A13 NDUFC2;NDUFC2-KCTD14 TRAP1 SURF1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 NDUFS5-1 HCCS TMEM186 RAB5IF ACAD9 COQ10B TMEM177 DMAC2 PET117 TIMMDC1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 COQ10A-1 SDHC OXA1L SDHD SDHA GOT1-1 SDHB NDUFB10 GOT2-1 NDUFB11 COX18 COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 TMEM126A-1 HIGD2A COX20 ETFA TMEM223 COA5 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 ETFDH NDUFB2 NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 COX15 COX4I1 COX4I2 HIGD1A COX19 CYCS-1 COX17 ECSIT NDUFS3 NDUFA4 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 PSENEN PSEN2 PSEN1 APH1A FLT4 PSMD8 NCSTN APH1B PSMD6 ACTA2 HES5 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 YWHAZ PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 SNW1 PSMA7 PSMB6 JAG1 ADAM10 PSMB7 PSMB4 PSMB5 DLL4 PSMB2 PSMB3 PSMB1 RPS27A KAT2B UBB;UBC KAT2A ADRM1 NOTCH1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 TACC3 PSMC1 RBPJ MAMLD1 SMAD2;SMAD3 AKT1 NOTCH2 NOTCH4 HEY1 MAML2 HEY2 HES1 MAML1 EP300 CREBBP METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host HBA2;HBA1 HBD;HBB PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds CYB5R3 MAOB PTGS1 CYP2D6;LOC107987479;LOC107987478-1 AOC1 CYP2J2-1 CYP2C9;CYP2C19 CYP2C18-1 AHR CYP2W1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 CYP2S1 PTGIS ADH4 CYP1A2 ADH1C;ADH1B;ADH1A TBXAS1 CYP1A1 AHRR ACSS2 CYP8B1 ALDH2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ALDH1B1 CYP2F1 ACSS1 ADH5 POMC CES3 PAOX CYP2R1 FMO1 BPHL CYP2U1 CBR3 CYP1B1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 AADAC CYP51A1 AOC3 AOC2 CMBL CES1 MTARC2 MTARC1 ARNT2 FMO2 NQO2 FMO3 CYP27A1 ALDH3A1 CYP4V2 PTGES3-1 EPHX1 NR1H4 CYP7B1 CYP7A1 HSP90AB1 RXRA MAOA FDX1 FDXR CYP26A1 CYP26B1 CES2 CYP24A1 CYP21A2 CYP11B1;CYP11B2 CYP46A1 CYP39A1 POR CYP27B1 ALDH1A1 ARNT CYP4B1 CYP4F22 CYP11A1 AIP NCOA1 NCOA2 CYP19A1 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 RBBP8 PCGF2 RNF2 EED RYBP UXT EPC1 RAD51 CDC7 EHMT2 EHMT1 CBX5 L3MBTL2 RBBP4 BRCA1 SUZ12 RBBP7 CHEK1 YAF2 CBX3-1 APAF1 PHC1 PHC3 E2F1 RRM2-1 E2F6 EZH2 BMI1 TFDP1 MAX RING1 TFDP2 MGA PCGF6 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis FDX1 FDXR FXN HSCB ISCA2 ISCA1 SLC25A28 LYRM4 SLC25A37 GLRX5 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS MBOAT1 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLA2G2F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4F PLA2G4E LPCAT4 PLA2G1B PLA2R1 PLA1A PLAAT3 PLA2G5 LPCAT3 OSBPL8 OSBPL5 PLA2G2A-1 PLA2G4A OSBPL10 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis DEGS1 OSBP MFSD2B SPNS2 PRKD3 PRKD2 PRKD1 VAPA CSNK1G2 KDSR VAPB FA2H DEGS2 SPTLC1 SPTLC3 CERS3 CERS4 CERS5 CERS6 SPHK2 ABCC1 CERS1 CERS2 SAMD8 SPHK1 SGMS1 PPM1L SGMS2 ORMDL2 ORMDL3 SPTSSB ORMDL1 ABCG2 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development NCOR1 CAMK4 CALM3;CALM1 TBL1XR1 HDAC3 GPS2 PRKACA-1 SIN3A NCOR2 HDAC1 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins SIN3A HDAC2 DCAF13 HDAC7 KLF4 PML INS;INS-IGF2 CD109 ZNF350;ZNF432 RAB27B CALU KCTD6 NPM1-2 SMAD1 SMAD4 CBX5 QSOX1 AHSG SMURF2 SMAD7 SPP2 AXIN1 APLP2 SCG3 THBS1 HSPD1 MMRN1 PLG ARRB1 ARRB2 UCHL1 SENP8 UCHL3 HCFC1 FOXK2 FOXK1 FGA MBD5 MBD6 ASXL1 FGG ASXL2 GOLGB1 ALG11 SRPRB-1 CAND1 EDEM1-1 PDIA6 CP TF KDELR3 DCTN1 SSR1 WFS1 SRPRA DBT DLD COL7A1 PCSK9 APOA2 APOA4 APOA5 GPIHBP1 JOSD2 JOSD1 ALB OTUD7B P4HB TNFAIP3 USP21 USP4 CYLD HSPG2 SDC2 ST3GAL6 B4GALNT2 B4GAT1 FUT6;FUT5;FUT3 CSF2RB CSF2RA B3GNT7 B3GNT4 GALNT11 GALNT14 B3GNT2 GALNT13 GALNT16 GALNT15 GALNT18 B3GNTL1 GALNT10 GALNT9 GALNT8 B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GALNT9;GALNT17 GCNT1 GCNT3 SLC17A5 GCNT4 GPC3 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT GALNTL5 GALNTL6 SPG7 AFG3L2 VDAC2-1 SMDT1 VDAC3 YME1L1 VDAC1 PMPCA MICU2 B4GALT2 B4GALT3 B4GALT1 HK1 BMP4 B4GALT6 B4GALT4 B4GALT5 ST6GALNAC6 RAB10 RAB14 RAB13 MGAT5B-1 TRAF3 IKBKE ALDH2 ALDH1B1 STAR MTA1 TOPORS TNC GALNT1 FBN1 LEP DPAGT1 ALG8 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 GATA6 TDG HSD17B10 MRPS17 GFM1 MRPS15 MMP2 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPS5 VGF MRPL43 TUFM MRPL44 DCAF8 DCAF5 MRPS18C MRPL52 DCAF6 MRPL53 WSB2 DCAF4;DCAF4L2;DCAF4L1 OXA1L COMMD5;LOC101928879 MRPS9 OBSL1 MRPL50 DCUN1D5 MRPL51 DCUN1D3 AURKAIP1 DCUN1D4 DAP3 MRPS36 DCUN1D1 MRPS33 COMMD8 MRPL18 COMMD9 MRPS34 PUM2 MRPL19 HIF3A DDA1 MRPS31 MRPL16 ANKRD9 MRPS35-1 COMMD2 MRPL17 COMMD3 MRPL58 COMMD1 MRPL14 COMMD6 MRPS30 COMMD7 MRPL15 COMMD4 MRPL12 SPSB3 CCDC8 MRPL57 MRPL13 CUL9 UBD MRPL10 NAE1 MRPL54 MRPL11 SOCS6 MRPL55 SOCS5 MRPL20 WDTC1 CCDC22 PTCD3 GADD45GIP1 DCUN1D2-1 COMMD10 MRPL27 TULP4 MRPL28 ERAL1 DCAF16 MRPL24 DCAF17 FEM1C MRPL21 MRPL22 DCAF10 LOC107987373;MRPL23 DCAF11 FEM1A MRPL30 FEM1B NEURL2 ERCC8 RHOA PDHB ARFGAP3 NDUFS3 RAB7A DLAT ME2 SHMT2 PDK1 PDHA1 LMAN1 STX5 YKT6 KTN1 CMA1 SERPINC1 LYZ-1 CALB1 BACE1 MFGE8 APCS TSPAN33 CST3 TTR TSPAN5 ODAM NAT8-2 SNCAIP SORL1 TSPAN15 TSPAN14 TGFBI ITM2B PCSK2 PCSK1 ERO1B KIF5C KIF5B GMPPB ANPEP PMM1 MPI KIF5A CPA3 GMPPA PMM2 SLC30A8 MME SLC30A5 ATP6AP2 GZMH-1 CES1 ABCA3 ENPEP CPB1 GPR119 PLA2G7 DAG1 CRHR2 ISL1 DPP4 CLTRN ACE CUL2 GSPT2 CDX2 GSPT1 INHBB MBOAT4 INHBC INHBE CPE PABPC1;PABPC3 REN TFAM-1 USP33 ETF1 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 CTSA SLC35A1 NUS1 ST8SIA1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ACE2 SQSTM1 CHRDL1 FSTL1 ARF1 CTSZ HSPA8 N6AMT1 MAT2B TRMT112 ADRA2C ADRA2A FGF23 CKAP4 LRR1 CCNF KEAP1 UBE2L6 HERC2 FBXO7 FBXO9 WSB1 FBXO2 RNF123 UBE2J2 IL33 SIAH2 SIAH1 MMP1 FBXL8 FBXL4 FBXL7 LRRC41 GAN GPR75-ASB3;ASB3-1 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 KBTBD8 SPSB4 FBXO27 LTN1 UBE2Z FBXO21 FBXO22 FBXW12 ARFGAP2 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 UBE2V2 CUL7 CUL5 UBA6 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBA3 UBA1 UBE2K KBTBD13 MAN1A2 MAN1C1 UBE2Q2 MAN1A1 ECI1 UBE2R2 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 RCHY1 ASB18 FBXL22 ASB15 RAB32 ASB16 RAB31 FBXL20 RAB38 ASB10 RAB21 VHL CHML FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 RAB39A FBXL12 RAB39B RAB18 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB1 TADA3 PNPLA2 CTBP1 ALAS1 FECH DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 DNMT3B DNMT3A DNMT1 PSENEN APH1A NCSTN APH1B POLB GNAT3 FCGR3A;FCGR3B NLRP3 MYO5A CTSG ADORA2B TRIM27 USP13 TNKS TNKS2 RNF146 OTUD3 NSF GRIA1 PAX6 RIPK2 SAA2;SAA1 USP14 NOD1 NOD2 TNIP2 USP18;USP41 CAMKMT CCP110 ARF4-1 CSNK1D CETN2 ACTR1A RAB8A EXOC8 EXOC7 EXOC4 EXOC3 DMP1 EXOC6 LGALS1 AMELY;AMELX EXOC5 EVA1A EXOC2 CCN1 EXOC1 CHGB DCTN2 IGFBP5 IGFBP4 DCTN3 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 IGFBP6 AMBN FUCA2 GBF1 TMEM132A BPIFB2 RAB11A HRC MELTF MIA3 MSLN PRSS23 BMP15-1 MEPE RCN1 APOL3;APOL4;APOL1;APOL2 ENAM AMTN VWA1 FAM20C FAM20A MATN3 PAPPA2 ITIH2 AFP FSTL3 SERPIND1 GOLM1 KLK13 NUCB1 NOTUM TRRAP NAPA NAPB NAPG TGOLN2 USP34 RAB6A RAB6B COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 RAB9A RAB9B CTSH EIF5 EIF5B RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 AMFR RNF103 TRIM13 UQCRQ DDX5 UQCRC2 CTSD SPTAN1 ANK2 ANK3 ANK1 SPTB SARS1 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 STARD7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 FBXW11 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 ACHE PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RELA PSMA7 PSMB6 PSMB7 BCHE PSMB4 RAB3A PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RUVBL1 NFRKB PIAS4 ACTR5 HDAC4 PIAS3 UBE2I RAD23A THRB ACTR8 VDR NR1H2 RORA RAD23B INO80C NR3C1 INO80B ESR1 INO80E NR2C1 INO80D NR3C2 PIAS1 COPS7B NR4A2 COPS7A NR5A1 XPC AR RXRA TFPT MCRS1 SUMO1 SUMO3 INO80 COPS3 SUMO2 RARA COPS6 PPARG PGR PPARA COPS8 BRCA1 BDH1 OXCT1-1 HMGCS2 ACAT1 USP10 TWNK MANEA SSBP1 EIF4A2 BLM EIF4A1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H PCNA EIF3M EIF3K EIF3L WRN EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B BARD1 OTULIN RPA1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 BRCC3 PALB2 CLSPN TP53BP1 RCE1 BABAM1 BABAM2 UIMC1 RARS2 ABRAXAS1 AARS2 RNF168-1 PARS2 MARS2 DARS2 RAD52 YARS2 HARS2 FARS2 WARS2 LARS2 GARS1 UBE2C SARS2 PPA2 PRMT3 H2AC16;H2AC11 NARS2 UBE2E1 TARS2 UBE2D1 IARS2 VARS2 CARS2 EARS2 UBE2S HSP90B1 CDK1 STAM HGS CTNNB1 STAM2 PRKDC MCFD2 SERPINA1 PPP6C TFG PPP6R1 PPP6R3 CTSC TMED2-1 TRAPPC2L TRAPPC2;TRAPPC2B LMAN1L F5 TRAPPC6A F8 TBC1D20 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TMED10 STX17 LMAN2L RAB1B GOSR2 USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC3 TRAPPC1 HDAC3 TRAPPC4 TRAPPC10 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 NRIP1 SFTPB EP300 OMA1 APOB PPARGC1A NCOA1 OPA1 NCOA2 CREBBP APOA1 NFE2L2 TPGS1 TTL TPGS2 SVBP CALM3;CALM1 TTLL12-1 ARPC4-TTLL3;TTLL3 AGTPBP1 NICN1 APP LRRC49 VASH2 VASH1 AGBL5 TTLL7 CDC25A AGBL4 TTLL6 TTLL5 TTLL4 GOLGA2 AGBL1 AGBL3 TTLL1 AGBL2 TTLL11 TTLL9 RBX1 RAB2A GNGT1 GIP IAPP CALCA GNG10 GNG2 GNG5 GNG4 GNG8 TOMM20 CD55 TIMM17A-1 CHCHD2 LDHD ADRB2 CS ACO2 GCG GNG13 GNB2 GNB1 GNB4 TIMM22 GNB3 GNB5 TIMM10 CUL3 KBTBD7 XRCC4 ACAD8 ACADSB BAP1 UBXN1 VCAN USP30 GLB1 PGAP1 LYPD1 LYPD2 LYPD3 THY1 ARSB LYPD4 LYPD5 LYPD8 CDKN1A RHOT1 FUCA1 LYPD6B PIGS PIGU PIGT PIGO PIGN PIGP SKP2 DAXX PIGZ PIGW PIGV CHST8 CRPPA PIGC CCNE2 PIGB PIGA CCNE1 PTRH2 PIGK PIGM NUP107 PIGL PIGG PIGF SMC3 ARF5 PIGH CDC20 FAM86B1;EEF2KMT;FAM86B2 ARCN1 ETFBKMT LY6K POFUT2 LY6D SUDS3 LY6H ATXN7 DYNC1LI1 SPRN ETFB SPACA4 DYNC1LI2 MDGA2 ALG10;ALG10B MDGA1 RECK KDELR2 NRN1 CDCA8 ART3 ART4 SNX3 NTNG1 NUP160 NTNG2 BST1 GPAA1 OTUD7A NUP85 MIA2 RAB22A RAD21 KIN STAMBPL1 NDUFAB1 ENGASE OTUD5 RXYLT1 STAG1 PRND STAG2 EMID1 RPS27 VCPIP1 CNTN5 UBE2T ALPL CNTN3 CNTN4 NGLY1 MYSM1 SEC13 VCPKMT NUP133 MMRN2 OTUB1 OTUB2 GSN GOSR1 TEX101 RAB40C RANGAP1 TNIP1 SMC1A RNF128 GPLD1 INCENP LIPT2 LIPT1 BIRC5 CHST10 SFTPC GP2 TADA2B ASGR1 DYNC1I2 ASGR2 PRSS21 AURKB TNIP3-2 COPZ2 COPZ1 WDR20 NUP43 METTL21A ULBP3;ULBP1;RAET1G;ULBP2;RAET1L DYNC1I1 PRSS41 EEF1AKMT2 EEF1AKMT1 RAB3B RAB3C RANBP2 DYNC1H1 RAB3D B3GALNT2-2 RAB44 RAB42 LARGE2 TECTB RAB2B USP5 USP3 RAB30 RAB36 RAB37 RAB34 FKBP8 STAMBP RAB4B GCSH-3 PLET1 CPM NUP37 PRL PSCA RTN4RL2 BET1L METTL22 PTP4A2 RTN4RL1 RAB20 RAB25 RAB26 RAB23 RAB24 RAB29 FKTN SLC35A4 FKRP RAB15 RAB19 RAB17 FOLR2 NFU1 YOD1 FUT10 FUT11 UMOD LIAS OTOA MLEC ZRANB1 TMED3 TMED7 TMED9 ABCE1 CTR9 IZUMO1R WDR61 NRN1L RTF1 LY6G6C CDC73 LSAMP COPG2 TMEM129 HLTF COPG1 COPB2 LEO1 COPA RNF152 SHPRH NTM PEX10 COPB1 PEX2 MAN2A2 PEX12 PIGX-1 PEX13 TMEM115 PEX14 COPE RNF40 USP37 RNF144A USP47 SELENOS USP48 FDX1 WAC-1 USP49 RNF181 USP42 PAF1 H2AC14 USP44 PLAUR POMGNT2 MYC USP26;USP29 USP16 PROS1 ABRAXAS2 OPCML CSNK2A2 USP24 CSNK2B USP25 USP20 NEGR1 RPN2 USP22 EPAS1 USP28 XPNPEP2 RPN1 POMK TECTA;TBCEL-TECTA GAS6 GFM2 LY6E MTRF1 MTRF1L HIF1A MRRF H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MGAT3 H2AC20 H2AB2;H2AB3;H2AB1 RAB27A MYRIP MAGT1 B3GNT3 CSNK2A1;CSNK2A3 DERL1 DERL2 ASCC2 OS9 ASCC3 NAPSA CCDC59 ADA2 PGA4;PGA3;PGA5 ADGRF5 LMCD1 SUZ12 H2BC5 STAT3 H2BC1 VCP-1 TUSC3 ANO8 H2AC4 TMEM258 SEL1L OST4 NFKB2 COPS5 OSTC STT3A PCCB STT3B RNF185 H2BC21 WDR5 HTRA2 FOXL2 HIC1 H2AZ2;H2AZ1 SP3 LONP1 DDOST APEH DAD1 RNF5 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L2 H2BC15;H2BC3;H2BC11;H2BC12 ELOC-1 ELOB CDH2 NADK2 TAF10 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DCAF7 CCT6B PFDN4-1 PARK7 TUBA1C PPA1-1 TUBA1A KIF13A TUBB1 FBXO4 LONP2 CFTR FBXO6 RGS9 AXIN2 RGS6 RGS7 FBXW4 CCT3 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 TUBA4A XRN2 TCP1 GAPDHS PFDN1 PFDN2 FKBP9 TP53 PFDN5 TUBB3;TUBB6 PFDN6 TUBAL3 GBA ARL2 GNA14 AP3M1 GNA15 GNA11 CCT8 TUBA3E;TUBA3C-1 CCT7 CCT5 CCT4 NOP56 ARFGEF2 TBCD TBCC TBCB TBCA TUBB4B HADH CCT6A TUBB4A;TUBB;TUBB8B;TUBB8 ACTB-1 GNAQ TBCE PDCL SKIV2L FBXL3 RGS11 FBXL5 PROC TUBA8 DDX58 WRAP53 NUP205 IFIH1 NUP188 RNF135 AAAS MAVS TRIM25 NUP42 NUP62 TPR NUP88 RAB5B RAE1 RAB5C NDC1 NUP214 RAB5A NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SLC25A5 SLC25A6 RPL4 RPL30 RPL3 CALR-1 RPL32 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 TGFB1 EIF2AK2 RPL3L RPS25 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 RPS4X RPL7A RPLP2 RPL36-1 PARP1 RPS3A DNAJC3-1 CANX GALNT12 RPL13A-1 SEMA5A POMT2 RPL11 RPS27L SPON2 RPS15A SEMA5B SPON1 RPL14 THSD7B RPS3 POMT1 RPL13 RPL12-1 ADAMTSL3;ADAMTSL1 ADAMTSL1 RPS2 RPL18 ADAMTS4 RPL17 ADAMTS5 RPL19 C1GALT1C1 RPL35A ADAMTS2 RPL23A ADAMTS3 ADAMTSL5 RPL22L1 ADAMTSL4 FAU ADAMTS1 ADAMTSL2 RPL26L1 MUC12 ALG14 MUC13 MUC15 THSD7A ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUC3A POMGNT1 MUC5AC ADAMTS20 B3GLCT CFP VNN1 THBS2 ADAMTS12 VNN2 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 MUC2 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 SUCLG2 GALNT3 MUC17 C1GALT1 MUC5B MUC20 MUC21 U2AF2 FH NDUFA13 NDUFV3 NDUFV1 IDH2 FFAR4 FFAR1 IDH3A F2 GRP NDUFS1 NDUFB6 AGT LAMB2 FN1 LAMB1 LAMC1 SRP19 SRP14 TRAM1 SRP54 KNG1 SSR4 SSR2 SSR3 B2M SRP9 SRP72 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SRP68 PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 POMP PSMB10 PSMA8 P2RY2 PSMF1 PSMB8 PSMB9 PSMG3 PSMG4 PSMG1 PSMG2 CDC34 TRAF6 UBE2D3;UBE2D2 UBE2N OGDH DLST TAB1 CSF1 QARS1 AMER1 KDM8 STS OGFOD1 ARSA JMJD4 DHPS RARS1 FN3KRP JMJD7 SUMF2 SUMF1 MARS1 JMJD6 TPST2 F7 MITF TPST1 F9 RCCD1 DARS1 EIF5A2 DNAJC24 LARS1 ARSL DPH1 DPH2 EEF1E1 ARSJ HDAC1 ARSK KARS1 ARSH ARSI IARS1 DPH5 DPH6 DPH7 ARSG POMC AIMP1 ZC3H15 AIMP2 RWDD1 FN3K EPRS1 ICMT F10 EIF5A;EIF5AL1 DOHH ARSD-1 RIOX1 GGCX RIOX2 DRG1 DRG2 CPB2 CGA TSHB GPS1 RNF20 GLUD1;GLUD2 COPS4 ANKZF1 COPS2 KLHDC10 TCF25 NEMF HNRNPC ZNF598 ARFGAP1 FURIN TGFBR1-1 H2BC18 TGFBR2 MDH2 BECN1 RRAGA EIF4EBP1 C12orf65 EIF4E TARS1 EIF4B AARS1 HARS1 FARSA FARSB KLK3;KLK2 MIEF1 MALSU1 MTFMT IDE YARS1 EIF4G1 NARS1 CARS1 VARS1 MTIF2 MTIF3 ECH1 WARS1 MTRES1 STX1A VAMP2 APC SLC34A2 SLC34A1 MVD ACOT2;ACOT1 SEC23A SAR1B CISH SOCS2 MBTPS1 SEC24B SEC24A SEC24D-1 SEC24C KDELR1 TRAF2 UFD1 SFTPD BIRC2 BIRC3 PRKN RIPK1 OGT-1 ATP5F1A ATP5F1B NPLOC4 HNRNPK ATP5MG HSPA9 ATP5PF ATP5PD ATP5F1C ATP5PO WDR48 UBE2B DDB1 CUL4A DTL RAD18 CUL4B PRKACA-1 ASPH SEC11A SEC11C TOMM70 SPCS3 SPCS2 SPCS1 PDIA3 LTF MDM2-2 TXN IGFBP7 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM4 BMI1 CCNA2-1 SMC5 RING1 SMC6 DDX17 NSMCE3 NSMCE2 CCNA1 NSMCE1 MRTFA EID3 RNF2 ZBED1 UBA2 SAE1 TOP2A TOP2B ZNF131 SENP5 SENP2 SAFB SENP1 NSMCE4A TOP1 CDKN2A SP100 UHRF2 SATB1 CASP8AP2 NOP58 RWDD3 MBD1 AREG EEF1B2-1 EEF1G EEF1A1 EEF1D EEF1A2 EEF2 ADAM10 ARG2 MUL1 DPP3 C3-1 LOC110384692;C4A;C4B_2;C4B UBXN7 ALPG;ALPP;ALPI-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 COP1 ST6GALNAC2 PRKCSH MGAT4A-1 ZDHHC2 GANAB FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 MDC1 GATA4 GATA3 SNCA GGA2 GGA1 GGA3 ACTL6A RAB8B DDB2 RAB4A RAB33A RAB33B-1 RAB11B RAB35 RAB7B SPP1 USP9X IGF2 IGF1 YY1 SYVN1 KDM1B FOXO4 SOCS3 ATXN3 FBXO32 TFAP2E;TFAP2B OXSM COX4I1 CLPX CLPP PTEN ALDH18A1 MSRA PCMT1 MSRB2 MSRB3 RABGGTB RABGGTA ADORA2A LHB PENK TRIM28 FSHB L3MBTL2 TGFA APOE SATB2 COX5B COX5A NPPA SMAD2;SMAD3 SEC61A2 SEC61A1 TFAP2C SEC61G SEC61B CAPZB CHD3 CAPZA1 CAPZA2 TIMP1 AURKA INHBA INHA USP15 LTBP1 UCHL5 USP8 TTF1 PRELID1 CHM UBE2D3-1 ING2 NCOR2 KAT2B KAT2A PCGF2 HIPK2 MEN1 IGFBP1 USP7 IGFBP3 USP2 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening CACNB2 CACNB3 CACNB4 CACNA1B CACNG2 CACNA2D1 CACNA1A CACNA2D3 CACNA1E CACNG4 CACNA2D2 CACNB1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives GPX1 PTGS2-2 ALOX15 ALOX15B GPX4 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants MAP2K2;MAP2K1 JAK2 MAPK1 BRAP FGB HRAS CAMK2G FGA MAPK3 KSR1 VWF FGG BRAF KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 ITGA2B MAP3K11 VCL FN1 CALM3;CALM1 CSK MARK3 SRC KRAS CAMK2B CAMK2D ITGB3 CAMK2A ARAF PEBP1 ARRB1 YWHAB PHB IQGAP1 ARRB2 NRAS RAP1B RAP1A NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency NAGS UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins MAP2K2;MAP2K1 CALM3;CALM1 MAP2K7 FURIN PDCD6IP MAP2K4 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins RPA1 TRIM28 TP53BP1 HNRNPK SIN3A RNF168-1 RAD52 MITF L3MBTL2 XRCC4 HDAC2 IKBKE SUZ12 HDAC1 HDAC7 MTA1 PML TOPORS EIF2AK2 SATB2 NFKB2 DAXX MDC1 DDX5 ZNF350;ZNF432 NUP107 SMC3 PARP1 FOXL2 HIC1 SP3 NPM1-2 CBX5 TFAP2C CDCA8 NUP160 TDG MDM2-2 NUP85 TRIM27 RAD21 CHD3 CETN2 CBX8 HNRNPC STAG1 PHC2 STAG2 PHC1 AURKA CBX4 CBX2 PHC3 SEC13 NRIP1 EP300 NUP133 PPARGC1A BMI1 NCOA1 RANGAP1 SMC1A SMC5 NCOA2 SMC6 RING1 DDX17 CREBBP INCENP NSMCE3 BIRC5 NSMCE2 NSMCE1 MRTFA EID3 ZBED1 RNF2 AURKB TOP2A TOP2B ZNF131 NUP43 SAFB NSMCE4A TOP1 CDKN2A IKBKG SP100 RANBP2 UHRF2 SATB1 CASP8AP2 NOP58 MBD1 PARK7 VHL NUP37 RELA ING2 NCOR2 TP53 NFKBIA PIAS4 HDAC4 PIAS3 UBE2I PCGF2 THRB VDR NR1H2 RORA NR3C1 HIPK2 ESR1 NR2C1 NR3C2 PIAS1 CTBP1 NR4A2 NR5A1 AR XPC RXRA SUMO1 SUMO3 SUMO2 RARA PPARG PGR NUP205 PPARA NUP188 AAAS TFAP2E;TFAP2B BRCA1 NUP42 NUP62 TPR NUP88 RAE1 NDC1 NUP214 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 BLM DNMT3B DNMT3A PCNA DNMT1 HERC2 WRN ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria CASP8 NMT1 GZMH;GZMB-1 BID SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism PSPH SRR PHGDH SERINC1 SDS SERINC3 PSAT1 SDSL SERINC2 SERINC5 SERINC4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression ACACB FASN ACACA MLX AGPAT1 ACLY INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling PTPN11 JAK2 IL26 IL24 TYK2 JAK1 IL19 IL20RA IL20RB IL22RA2 IFNLR1 IL10RB IL22RA1 IFNL2;IFNL3;IFNL1 STAT2 STAT5A STAT5B STAT4 STAT1 STAT3 JAK3 IL22 IL20 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes GSTA3;GSTA1 ATF4 TXN TXNRD1 PRDX1 MAFK GCLC NFE2L2 BACH1 GCLM SRXN1 CHD6 SLC7A11 EP300 HMOX1 NQO1 SOD3 CREBBP PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH1 NOTCH2 POGLUT1 POFUT1 NOTCH3 NOTCH4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression MPHOSPH8 SIN3B H2AJ SIN3A DDX21 SMARCD1 HDAC2 SMARCD2 SUZ12 H2BC5 HDAC1 H2BC1 SMARCE1 ZCCHC8 MTA1 MTA3 H2AC4 KMT2A KMT2C RBM7 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 PPHLN1 TASOR GSK3B DPY30 H2BC21 WDR5 EED H2AZ2;H2AZ1 CCNC-1 CBX5 AGPAT2 RBBP4 PPARGC1B RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYBBP1A RBBP7 TDG ZNF30 CBX3-1 SMARCD3 HDAC3 H2BC15;H2BC3;H2BC11;H2BC12 MED16 ARID1A ARID1B MED17 MED12 MED14 MED13 MED10 MORC2 EP300 TBP PPARGC1A ADIPOQ ACTL6A DEK NCOA1 MED27 MED1 NCOA2 MBD2 CREBBP MED23 NCOA6 MED24 SIRT1 MED20 HCFC1 DNMT3L NCOR1 SPOCD1 TBL1XR1 C19orf84 PIWIL4 MBD3 ZNF669;ZNF670 GATAD2B GATAD2A PLIN2 CDK5 KAT8 PHLDA1 BOD1L2;BOD1 ACSL1 HCFC2 WDR82 PEX11A RRP8 BOD1L1 MBIP TASP1 DR1 CIDEC TADA2A ZZZ3 KMT2D YEATS2 TADA3 AKAP8L SGF29 ELOVL5 PHF20L1 KMT2B PLIN4 GPAM KANSL1 POLR1C SCD KANSL2 MED30 KANSL3 POLR1D THRSP PNPLA2 ACTB-1 UHRF1 CXXC1 TET3 KDM6A PSIP1 ZNF649 ZNF264;ZNF805-1 OGT-1 DNMT3B DNMT3A DNMT1 PDK4 SMARCB1 TRIM28 SMARCC1 SMARCC2 PAXIP1 SMARCA5 SF3B1 BAZ1B LIPE SMARCA2 SMARCA4 DGAT2 ANGPTL4 FABP4 LPL RB1 PLIN1 LPIN1 MGLL ARID4B MED31-1 SAP30 NCOA3 NR5A2 SAP30L SAP18 SUDS3 ZNF354A;ZNF354B-4 EHMT2 EHMT1 ZNF324B;ZNF324 PAGR1 AJUBA CHD4 CHD3 MTA2 EZH1 PHF19 EPOP PHF1 JARID2 TET2 TET1 MTF2 MED4 MED6 MED7 TTF1 SAP130 UBTF SAP30BP ZNF382 POLR1A SETD1B POLR1B SETD1A POLR1E POLR1F POLR1G POLR1H BAZ2A TAF1D TAF1B TAF1C TAF1A CD36 NCOR2 SUV39H1 KAT2B KAT2A ATF7IP SETDB1 GPS2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH AEBP2 POLR2E UBE2I POLR2F POLR2H POLR2L ERCC6 GTF2H1 GTF2H3 ZNF331 GTF2H4 CDK7 RXRA MCRS1 ERCC3 ERCC2 MNAT1 SUMO2 H2AC14 MEN1 MTREX ACSS3 ZNF317 PHF20 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CEBPA ABL1 BCL7A BCL7C DPF1 H2AC20 BCL7B DPF2 DPF3 H2AB2;H2AB3;H2AB1 SS18 SS18L1 EZH2 CDK8 ASH2L IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R FLT3 PIK3CB HRAS PDPK1 FRS2 KLB IRS1 PDE3B PIK3CA PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 GAB1 FGF9 SOS1 AKT2 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 TRIB3 PIK3C3 FGFR4 IRS4 IGF1R FGF10 IGF2 PTPN11 FLT3LG IGF1 PIK3R2 PIK3R1 THEM4 NRAS SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs DUSP6 RAC1 DUSP7 RPS6KA1 FOS AP2A1 AP2A2 NTRK3 AP2M1 STAT3 FOSB ID1 SH3GL3 SRC AP2S1 EGR1 SH3GL2 SHC2 AP2B1 SHC3 RALB YWHAB CRKL CLTC NRAS RAP1A CLTA MAP2K2;MAP2K1 PIK3CB MAPK1 RALGDS HRAS EGR2 MAPK3 NTRK1 KIDINS220 BRAF FRS2 PTPRO PPP2R1B MAPK14 PPP2R1A RALA-1 NGF PIK3CA MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK RPS6KA3 SHC1-1 RPS6KA2 ATF2 CHD4 PTPN11 DNM1 DNM3 PPP2CB;PPP2CA REST NELFB EP300 SGK1-1 FURIN PCSK6 PPP2R5D PCSK5 MEF2D JUNB MEF2C MAPK7 NAB1 NAB2 NTRK2 ARC DOCK3 TRIB1 BDNF TPH1 GAB1 RRAD GRIN2B FRS3 MAP2K5 EGR3 NTF4 TIAM1 EGR4 FOSL1 NTF3 PLCG1 ID3 DNAL4 ELK1 ID2-1 LYL1 F3 VGF ASCL1 CDK5R2 CDK5 CDK5R1 TCF12 DNM2 PTPRS IRS1 ADCYAP1 IRS2 ADCYAP1R1 RHOA RPS6KA5 PIK3R2 PIK3R1 ID4 JUND ADORA2A SRF ATF1 BAX DUSP4 MEF2A DUSP3 VRK3 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMC2-1 PSMA5 YWHAZ PSMA6 AKT1 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 NOTCH4 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 TACC3 PSMC1 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation MAPK1 MAPK3 RPS6KA3 RPS6KA2 RPS6KA1 PDPK1 RPS6KA6 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling PIK3CD JAK2 IL2RB PIK3CB IL2RA JAK1 IL15 SYK CSF2 PIK3CA LCK SOS1 PTK2B SHC1-1 GAB2 IL2 IL3 STAT1 STAT3 SOS2 PIK3R3 IL9 PIK3R2 IL9R PIK3R1 PTPN6 IL2RG INPPL1 HAVCR2 INPP5D STAT5A STAT5B LGALS9C;LGALS9;LGALS9B STAT4 GRB2 IL21R IL5RA CSF2RB IL21 CSF2RA JAK3 IL5 IL3RA LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival GNB1 GNB4 GNB3 GNB5 HCK CALM3;CALM1 PLCG1 AHCYL1 CYSLTR1 CYSLTR2 GNAT3 GGT1 PRKACA-1 ADAM17 ADCY9 PRKAR1B PRKACB-1 DPEP2 DPEP1 GNAZ FCGR3A;FCGR3B IL10 PRKAR2B CD163 PLCG2 PLK2 RHBDF2 MYH9 ITPR1 GGT5 GNGT1 ITPR2 ITPR3 SYK GNAS-1 FGR MAPK14 ADORA2B ADCY4 GNAI3 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 GNAI1 PRKAR1A ADCY6 GNAI2 ADCY5 FCGR1A FYN GNG10 GNG2 GNG5 GNG4 GNG8 LYN YES1 IL6 FURIN CD3G GNG13 GNB2 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors CASK CAMK2G LIN7A LIN7C LIN7B DLG1 DLG3 DLG4 ACTN2 GRIN2C GRIN3B GRIN3A GRIN1 NBEA GRIN2D GRIN2A DLG2 NEFL GRIN2B KIF17 CAMK2B CAMK2D CAMK2A APBA1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 PTPN11 HRAS PIK3R1 FRS2 PIK3CA FGF1 FGF2 FGF3 FGF4 FGF6 GAB1 FGF7 FGF9 SOS1 FRS3 FGF20 FGF23 FGF22 FGF16 PLCG1 FGF18 NRAS FGF10 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein PARP9 UBE2I PARP14 PARP8 PARP10 GSK3A PARP6 PARP4 GSK3B SUMO1 PARP16 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 KCNJ2 KCNJ3 KCNJ12;KCNJ18 KCNJ4 KCNJ5 GABBR2 GABBR1 KCNJ6 KCNJ10 KCNJ9 KCNJ15 KCNJ16 GNG13 GNGT1 GNG10 GNB2 GNG2 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation ST6GAL1 MGAT4C MGAT4B B4GALT6 ST8SIA6 B4GALT4 B4GALT2 B4GALT5 B4GALT3 ST8SIA2 B4GALT1 MGAT4A-1 ST8SIA3 MGAT5 ST3GAL4 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology CNOT2 CNOT3 CNOT8 CNOT9 SIN3A KLF13 HDAC5 SMARCD1 HDAC2 SMARCD2 PLK1 HDAC8 HDAC9 HDAC6 HDAC7 CCNB1 SMARCE1 KLF4 HDAC10 HDAC11 TNF SH3KBP1 SRC RUNX3 CDH1 GRB10 CTNNB1 MET SH3GL2 SHC3 INS;INS-IGF2 STAT6 FOXH1 YWHAB DRAP1 NRAS MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 FRS2 MAPK14 MAPK12 MAPK11 SMAD1 SMAD4 SOS1 SHC1-1 KDM5B SMARCD3 CFL1 HDAC3 LEFTY2;LEFTY1 CHD9 ARID1A ARID1B IFNG HELZ2 XPO1 ERBB2 TGS1 HES1 EP300 PPARGC1A MEF2D DEK ITGB3 NCOA1 MED1 NCOA2 MEF2C NR2F2 CREBBP NCOA6 SIRT1 NCOR1 TBL1XR1 CARM1 BTG4 ZFP36L2 PPP3CB GRB7 TLN1 RND1 NFATC2 NFATC1 PLXNA1 YWHAE JUN FOXO3 CDC25B PKP4 ARHGEF11 ARHGEF12 CDK5 CAPNS1 RHOB CAPN1 ATP6V1E1 CDK5R1 ATP6V1G1 ATP6V0B ARHGEF28 NOTCH1 RBX1 ATP6V1B2 ATP6V0D1 JUP ATP6V0C IHH ATP6V1A DIAPH1 ATP6V1H SHH ATP6V1C1 SPRR3 CSTA KLK5 WNT9B EVPL KLK8 RHOC PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 ARHGEF7 TGM1 NGEF CASP14 ATP6V0E2;ATP6V0E1 LIPJ SPRR1A;SPRR1B LIPN LIPM IAPP PRSS8 LIPK TGM5 ST14 CDSN SPINK6 SPINK5 DHH KLK14 PLXNB1 KAZN CELA2B;CELA2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 WNT11 DSC1 IVL DSC2 DSC3 WNT1 WNT4 WNT10B WNT3A COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 COL6A5 COL9A2 RASA1 GPR143 AP2A1 AP2A2 PAXIP1 AP2M1 NCAN SEMA4D LIMK2 LIMK1 RRAS MYH14 MYH10 EYA1 ANGPTL4 CTNNA1 LPL FOXF1 PRKACB-1 CDKN1A AP2S1 CCND3 SNAI1 CCND1 PLXND1 E2F1 PBX1 AP2B1 TFDP1 TFDP2 CDK4 CDK2 SDC2 RPS27 PITPNA STAT4 IL12RB2 IL5 FGFR1 CLASP1 CLASP2 GPC1 AGRN PRL DSP DSG1 PKP1 DSG2 DSG3 POLR2A POLR2B POLR2C IL4 POLR2D POLR2E IL13 POLR2F POLR2G POLR2H POLR2I POLR2L FOXC2 FOXC1 POLR2J;POLR2J2;POLR2J3 SIX1 PCDH19 HOXD11 HOXC11 WFDC2 HOXA11 H2AC14 PLAC8 AKT2 SALL1 MYC SIX2 AKT3 HOXA6 AKT1 IRX1 IRX2 CSNK2A2 EMX2 OSR1 CSNK2B GFRA1 NPNT PAX2 POU3F3 EPAS1 GREM1 BMP4 PAX8 PIK3R3 GDNF PIK3R2 LHX1 PIK3R1 ID4 HOXB4 DIS3L2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LYN WWTR1 SLC2A4 YES1 PMEL BCL7A MLANA MOV10 BCL7C AGO4 DPF1 BCL7B H2AC20 AGO2 DPF2 DPF3 SS18 H2AB2;H2AB3;H2AB1 EZH2 SS18L1 RAB27A ACVR1C MYRIP CFC1;CFC1B SYTL2 ACVR1B MLPH IRF4 ASH2L TDGF1 ACVR2B NODAL DAND5 CER1 RAC1 NANOG;NANOGP8 ZIC3 TEAD1 TEAD2 SALL4 POU5F1;POU5F1B EPHA1 TEAD4 FOS H2AJ ARHGAP39 CSNK2A1;CSNK2A3 SRGAP3 SLIT2 AGO3;AGO1 SRGAP2 SRGAP1 ROBO1 PAK1 PAK3 PAK2 SUZ12 H2BC5 STAT3 H2BC1 UCP1 HNRNPU MTA1 PRDM16 ZNF423 MTA3 ELOVL3 CIDEA H2AC4 EBF2 BMP7 KMT2A KMT2C TCF7 GMPR STT3B GSK3B DPY30 PIK3CD PIK3CB H2BC21 EBF1 EGR2 WDR5 ADIRF YWHAG THRAP3 ZNF638 EED PRKCA FAM120B ZNF467 H2AZ2;H2AZ1 LEP PIK3CA CDON LEF1 CDC42 EOMES GATA6 RBBP4 TBXT RBBP5 YAP1-1 SOX17 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GSC MIXL1 FYN PRDM14 RBBP7 LIN28A TCF7L2 ZSCAN10 TCF7L1 TNRC6A-1 PTPN11 TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 TNRC6B ELOC-1 EPHB6 EPHB1 EPHB4 ELOB EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ADIPOQ NCBP1 MMP2 EPHA3 EPHA10 GXYLT2 EFNA5 CDH2 EFNA4 PXN EFNB2 TERT EFNB1 EDIL3 EFNB3 ZEB1 EFNA1 PXDN EFNA3 BIRC7 EFNA2 ASAH1 BCL2A1 TBX2 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 NCBP2-1 MAG NAB1 NAB2 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 HIF3A UNC5A UNC5B TP53 ACTB-1 KDM5A STPG4 UHRF1 AICDA CACNA1C METTL23 DPPA3 TET3 RHOA KDM6A RPS6KA5 SRPK1 ITGB1 ZIC2 TRIO ITSN1 ARHGAP35 RPL4 RPL30 RPL3 DOCK1 EPHA2 RPL32 RPL31 RPL34 RPL10A RPL8 RPL9 RPL6 KALRN RPL7 RPS15 RPS14 RPS17 PAK4 RPS16 RPL18A RPS19 RPS18 RPL37A-1 RPL35 RPL38 RPS11 RPL39 RPS10 RPL15-1 RPS13 FES RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 FABP4 TGFB1 CACNA1H MYL12A CACNA1G RPL3L PLIN1 MYL12B RPS25 RPL5-1 CACNA1I RPS29 RPL27A RPS20 RPS21 MYH11 RPS24 RPS23 RPL36AL-1 RPLP1-2 RPLP0 ITGAV CLTC PTK2 CLTA RPS4X RPL7A BUB1B-PAK6;PAK6 RPLP2 MSI1 RPL36-1 DAG1 MYL6 HSP90AA1 HOXA2 ISL1 PFN1 RPS3A CUL2 GSPT2 RPL13A-1 GSPT1 SEMA5A FLRT3 RPL11 PRKAR2A RPS27L RPS15A ABL2 RPL14 VASP PABPC1;PABPC3 RPS3 CXCL12 RPL13 RPL12-1 LHX3 RPS2 LHX2 LFNG RPL18 LHX4 RPL17 LHX9 RPL19 ROBO2 CTCF NRP1 RPL35A RPL23A PAGR1 USP33 NCK2 HOXA3 PABPN1-1 RPL22L1 NCK1 HOXA1 PKNOX1 UPF2 FAU CAP1 HOXA4 PIAS2 RPL26L1 DCC ENAH HOXB3 ETF1 HOXB2 HOXB1 EVL AJUBA PFN2-1 HOXD1 CBFB SOS2 HOXC4 CXCR4 RUNX1 AKAP5 MEIS1 NTN1 MAFB ZSWIM8 HOXD4 SLIT1 HOXD3 SLIT3 ZNF335 PAK5 CAP2 MYO9B NELL2 EIF4A3 CASC3 ST8SIA4 ST8SIA2 RBM8A MAGOH;MAGOHB UPF3B RNPS1 SOX2 ZEB2 AMH SOX1 FGF8 NOG GBX2 OTX2 TBX6 POU3F1 CLTB ZNF521 DICER1 TRPM1 HSPA8 DNM2 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 LAMA5 LAMB3 LAMA2 LAMB2 SHANK3 LAMA1 IRS2 LAMC3 LAMA4 FGF2 LAMA3 FN1 FGF4 LAMB1 LAMC2 FGF7 LAMC1 FGF9 VTN GAB2 FGF10 ITGA2 ITGA1 CEBPA CSF3R CEBPE GFI1 IL6R FLI1 KLF5 PRKCQ CSF1 MC4R HINT1 EDNRB QARS1 RPS6KA1 ZIC1 TNFSF11 SOX9 YWHAH FOXD3 EDN1 RARS1 BATF SIAH2 EDN3 IL4R SIAH1 TFE3 MARS1 TFEB TPST2 PAX3 MITF SOX10 POU3F2 YWHAZ DARS1 MC3R LARS1 TFEC KIT EEF1E1 HDAC1 KARS1 ALX3 IARS1 MARK3 TBX3 POMC AIMP1 AIMP2 MC1R EPRS1 ID1 MC5R SNAI2 VAV3 VAV2 HSP90AB1 ROCK1 ROCK2 CLTCL1 ACTG1 PIP5K1C NPM2 H1-8 HES7 TBPL2 MESP2 MCM5 MSGN1 RIPPLY2 MCM2 FURIN PAX7 PCSK6 DLL3 NOTO MSX1 EIF4E EIF4B EIF4G1 STX1A SREBF2 MED19 MED18 CYP51A1 MED11 MED29 MED22 MED21 DLG1 DLG3 DLG4 KRT1 GIT1 MED13L DPYSL4 SDCBP DPYSL5 DPYSL3 UNC5C UNC5D AGAP2 DSCAML1 PLXNC1 SEMA6A SEMA6D UTRN MMP9 SEMA7A RAP1GAP PLXNA2 MBP PLXNA3 PTPRC PTPRA RELN DAB1 PLXNB3 TREM2 VLDLR ADGRV1 SEMA3A SLC2A2 NTN4 MED9 SEMA3E ABLIM1 PSENEN PSEN2 ABLIM2 PSEN1 ABLIM3 APH1A SEMA4A ARTN NCSTN CDK19 APH1B PRX GFRA3 RGMB GFRA2 GFRA4 RGMA DRP2 CD72 SCD5 MPZ NRTN MED28-1 DSCAM DOK1 DOK2 TYROBP DOK4 DOK5 DOK6 ADGRG6 CACNA1S PRNP PSPN HJV CRMP1 HMGCR PDLIM7 PMP22 PRKACA-1 CEBPD MYO5A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3-1 ARPC1B ARPC1A WASL ACTR2 ETS1 RPS6KA3 RPS6KA2 MYO10 MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 LIG1 PHC3 BMI1 KDM6B RING1 CEBPB RNF2 HIRA MAPK7 CDKN2A SATB1 GAB1 GRIN2B TBX21 TIAM1 PLCG1 EGF BCL2 AREG RPS6KA6 CD36 JAG1 ADAM10 DLL1 MECOM CACNG8 CACNG2 CACNG3 CACNG4 ONECUT1 NEUROD1 NTN3 NKX6-1 NKX2-2 CDH4 BNIP2 PDX1 PAX6 CTNNA2 NEO1 HNF1B HNF1A SPAG9 MYOG MAFA RFX6 MEF2B;BORCS8-MEF2B MYOD1 INSM1 PTF1A MYF6 FOXA3 TCF4 NEUROG3 CDH15 FOXA2 MYF5 MEF2A FARP2 WT1 GRIN1 MYH9 SPI1 RBPJ KRTAP24-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 KRTAP3-1 KRT16;KRT14 KRT71 KRT4 KRT2 KRT79 GATA4 KRT8 GATA3 KRT7 KRT78 GATA2 KRT77 KRT5 KRT75 CCNC-1 KRT74 KRT73 KRT9 PPARGC1B KRT72 KRTAP13-1;KRTAP13-2 KRT6B;KRT6C;KRT6A KRT10-2 KRTAP27-1 KRT40 KRTAP4-3 KRTAP13-4;KRTAP23-1;KRTAP13-3-1 KRTAP16-1 KRTAP8-1 KRT81;KRT83-1 KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRTAP9-4;KRTAP9-3;KRTAP9-8;KRTAP9-7;KRTAP9-6;KRTAP9-2;KRTAP9-9-1 KRTAP26-1 KRT24 MED16 KRT23 MED15 KRT20 KRT33A;KRT33B;KRT31-2 MED17 KRT28 MED12 KRT27 MED14 KRT26 MED13 KRT25 HEY1 KRTAP11-1 KRTAP3-2;KRTAP3-3-1 MED10 KRT32 HEY2 KRTAP19-5 KRT3;KRT76 KRT39 KRT36 KRT82 CNOT6L KRT80 KRTAP29-1 ACTL6A KRT85 MED27 KRT84 MED26 KRTAP10-8 KRT13 KRT12 MED23 KRT19 MED25 KRT18 KRT17 MED24 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 MED20 KRT15 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 EGFR MBD3 GATAD2B GATAD2A TUT7 TUT4 LEUTX YY1 DPPA4 DPPA2 TPRX1;RAX2 ZSCAN4 DUX4;DUXA DUXB PAIP1 MAF KMT2D DLX5 KLK13 FOXO4 MED30 TFAP2E;TFAP2B MESP1 TBX20 SMYD1 SRY TBX1 MYOCD HAND1 GDF1 CCL3L1;CCL3L3;CCL3;CCL18 HAND2 ITGA5 SRF TBX5 TRIM33 SMARCB1 SMARCC1 SMARCC2 TGFA PCK1 SMARCA2 SMARCA4 SNW1 HNF4G HNF4A FOXO1-1 POU2F2 STAT5A STAT5B PERP GCK FOXA1 MED31-1 MAMLD1 POU2F1 NCOA3 USF1 NRP2 CNTNAP1 SMAD2;SMAD3 RPS6KA4 ALCAM TFAP2A SCN11A CHL1 DPYSL2 TFAP2C SCN9A NRCAM CNOT10 SCN5A EPHB2 SPTAN1 SCN1B SCN1A CNOT11 KIF4B;KIF4A LYPLA2 LDB1 ANK2 CHD4 ANK3 CHD3 ANK1 CACNA1D SPTB DNM1 DNM3 SHTN1 GAP43 SCN10A SCN8A KCNQ2 MTA2 NUMB DCX KCNQ3 SCN4A ACVR2A EZR SCN4B MAML2 ITGA9 MAML1 SERPINE1 SPTBN4 SPTBN5 SPTA1 SCN7A MYB NCAM1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN MED8 MED4 RANBP9 L1CAM MED6 MED7 NFASC ITGA10 CNTN1 CNTN2 CD24 SCN2A SCN2B PSMD8 NKX2-5 ITGA8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 RET PSMA4 PSMA1 UBA52 RARG PSMD12 PSMD11 PSMD14 PSMD13 RELA PSMA7 PSMB6 PSMB7 PSMB4 TNKS1BP1 PSMB5 PSMB2 PSMB3 PSMB1 TCF12 RPS27A NCOR2 UBB;UBC KAT2B KAT2A CACNB1 ADRM1 NFKB1 TAL1 CACNB2 RARB CACNB3 PSMA2-1 CACNB4 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 HDAC4 UBE2I PCGF2 NR5A1 ITGA2B RXRA SUMO1 RARA PPARG PPARA MEN1 BRCA1 KAT5 DCT NOTCH2 TYRP1 DMRT1 PTGDS TYR ZFPM2 ABL1 PLXNA4 EIF4A2 EIF4A1 CNOT4 CDK8 CNOT6 CNOT7 CNOT1 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs MYH10 CFL1 RHOC MYL6 RHOB PPP1R12A PPP1R12B ROCK1 ROCK2 RHOA MYL12B PAK1 MYH11 MYH9 LIMK2 LIMK1 PPP1CB MYH14 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm FGFR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMD12 PSMD11 PSMD14 PSMD13 SNW1 PSMA7 NOG PSMB6 PSMB7 DLL1 PSMB4 TBX6 PSMB5 PSMB2 PSMB3 PSMB1 KAT2B KAT2A ADRM1 NOTCH1 PSMA2-1 SEM1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RBPJ MAMLD1 LEF1 LFNG TBXT BMP4 WNT3A MAML2 HES7 MAML1 MESP2 EP300 EPHA4 MSGN1 RIPPLY2 DLL3 CREBBP NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription MAMLD1 NCOR1 TBL1XR1 HES5 HEYL SKP1 TLE1 HDAC5 CCNC-1 HDAC2 MYC HDAC8 UBA52 HDAC9 HDAC6 HDAC1 HDAC7 CUL1 SNW1 HDAC3 HIF1A HDAC10 HDAC11 HEY1 RPS27A NCOR2 UBB;UBC KAT2B NBEA KAT2A NOTCH1 MAML2 HEY2 HES1 MAML1 RBX1 EP300 TLE4 TLE2 CDK8 CREBBP HDAC4 RBPJ N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle EDEM1-1 RAD23B CANX RNF139 UGGT2 UGGT1 MARCHF6 PRKCSH EDEM3 AMFR DERL1 RNF103 DERL2 TRIM13 RNF5 OS9 PDIA3 GANAB UBXN1 UBA52 EDEM2 VCP-1 MOGS ENGASE MAN1B1 SYVN1 RPS27A UBB;UBC NGLY1 SEL1L PSMC1 CALR-1 MLEC RNF185 HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation POLR2E POLR2F POLR2G POLR2H SSRP1 POLR2I CDK9 POLR2L NCBP2-1 GTF2H1 SUPT5H TCEA1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 CCNT1 ELL ELOC-1 ELOA ELOB NELFB NELFA NELFCD NELFE SUPT16H NCBP1 GTF2H2C;GTF2H2C_2;GTF2H2 CTDP1 CCNH POLR2A POLR2B SUPT4H1-1 POLR2C POLR2D TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes SSRP1 CDK9 CCNT2-1 TCEA1 FOS ATM CDK12 CDK13 ATR JUN MSH2 PMS2 MLH1 TP53 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH MDC1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L GTF2H1 SUPT5H GTF2F1 GTF2H3 GTF2F2 FANCD2 GTF2H4 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 ERCC2 MNAT1 BRCA1 CHEK1 ATF2 CCNK CCNT1 ELL ELOC-1 ELOA ELOB RAD51D NELFB NELFA NELFCD NELFE SUPT16H FANCI FANCC CTDP1 DDB2 SUPT4H1-1 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport SLC2A2 SLC2A7 SLC5A2 SLC50A1 SLC2A8 SLC2A9 SLC45A3 SLC5A9 SLC2A10 SLC2A4 SLC5A4 SLC2A11 SLC2A12 MFSD4B-2 SLC5A10 FGF21 SLC2A1 SLC5A1-1 SLC2A6 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 SFTPD SFTPB CSF2RB CSF2RA SFTPC FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS4X EIF3F EIF3D EIF3A EIF3B RPS15 RPS3A RPS14 RPS17 RPS16 RPS27L RPS19 RPS15A RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 FAU RPS9 RPS7 RPS8 EIF2S2 RPS5 EIF2S3;EIF2S3B RPS6 EIF2S1 RPSA RPS27 RPS27A RPS25 RPS29 EIF3C;EIF3CL EIF1AY;EIF1AX RPS20 EIF3M RPS21 EIF3K RPS24 EIF3L RPS23 EIF3I EIF3J EIF3G EIF3H EIF3E TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment TLR3 UBE2D3-1 BIRC2 BIRC3 IKBKB RIPK1 RPS27A IKBKG UBB;UBC CHUK TICAM1 RIPK3 TRAF6 UBE2V1 UBA52 UBE2D1 UBE2D3;UBE2D2 UBE2N OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha LIMD1 PSMD8 EGLN1 EGLN3 PSMD6 EGLN2 PSMD7 WTIP PSMD2 PSMD3 PSMD1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 VHL PSMA1 UBA52 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 UBE2D3-1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC HIF3A ADRM1 RBX1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CUL2 AJUBA EPAS1 HIF1A ELOC-1 ELOB UBE2D3;UBE2D2 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria TP53 E2F1 TP53BP2 TP63 TP73 BBC3 TFDP1 PPP1R13B TFDP2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs ALOX5 PTGS2-2 ALOX15 ALOX12 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants KIT LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation GRIA1 CAMK2G DLG1 DLG3 DLG4 ACTN2 GRIN2C SRC GRIN1 GRIN2D GRIN2A DLG2 CALM3;CALM1 NEFL GRIN2B NRGN CAMK2B CAMK2D CAMK2A GRIA2 NRG1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes MAT1A FMO3 CYP27A1 GCLC GSS CYP7B1 GCLM MAOA FDX1 FDXR ACY1;ABHD14A-ACY1 CYP26B1 CYP24A1 TBXAS1 CYP21A2 CYP11B1;CYP11B2 UGT1A1;UGT1A6 SLC35D1 CYP27B1 CYP4F22 CYP11A1 GGT1 CYP17A1 CYP2R1 OPLAH CYP2U1 CYP1B1 TPMT AHCY CYP19A1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP2D6;LOC107987479;LOC107987478-1 CYP2W1 CYP2U1 CYP4B1 CYP2S1 CYP4F22 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants ALK SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins HGF MET TNS4 TNS3 ITGB1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding GNB1 GNB4 GNB3 GNB5 DLG1 DLG3 PLCB3 DLG4 GRIK5 PLCB1 GRIK3 PLCB2 GRIK4 GRIK1 GRIK2 NCALD CALM3;CALM1 GNG10 GNG2 GNG5 GNG4 GNG8 GNGT1 GNG13 GNB2 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling FLT3 HRAS SYK PIK3CA HCK ABL2 LCK SH2B3 SOS1 SLA2 AKT2 SLA AKT3 AKT1 GAB2 FYN FOXO3 CSK UBA52 PTPN11 BCL2L11 FLT3LG PTPRJ PIK3R1 GRAP2 RPS27A CDKN1B UBB;UBC CBL GRB10 STAT5A STAT5B SOCS2 SOCS6 NRAS CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events CAMKK2 MAPK1 CAMK2G PRKCA ADCY4 PRKAR2A ADCY3 PRKX ADCY2 ADCY1 ADCY8 CALM3;CALM1 PDE1C ADCY7 KPNA2 PDE1B PDE1A ADCY6 PRKAR1A GRK2 ADCY5 PRKCD PLA2G4A PRKCG PRKACA-1 ADCY9 PRKACB-1 PRKAR1B NBEA CAMK4 PRKAR2B CAMK2B CAMK2D CAMK2A CAMKK1 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus NUP107 NUP43 RANBP2 NUP205 NUP188 AAAS NUP42 NUP62 NUP160 TPR NUP88 RAE1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 SEC13 NUP133 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand POLD2 RPA1 RPA2 FEN1 LIG1 RPA3 DNA2 PCNA PRIM2 POLD3 PRIM1 POLD4 POLA1 POLA2 POLD1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing HNRNPU RBM7 DDX41 DHX9 TCERG1 SNRPC SNRPA PPP1R8;STX12 HTATSF1 RBM25 SNRNP70 PRPF40A SRSF10 SRSF12 TRA2B RBM39 YBX1 HNRNPC RBMX NCBP1 ACIN1 NCBP2-1 PPIL2 PQBP1 ZNF830 SRRT ZCRB1 SNRNP200 FUS BCAS2 CTNNBL1 PRCC HNRNPA3 GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 DHX16 HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 PDCD7 BUD31 SNRNP35 SNRNP25 RBM22 DDX23 ZRSR2-1 RNPC3 ZMAT5 SMNDC1 SNRNP48 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD GPATCH1 PNN HNRNPA1-1 CXorf56-1 SF3B4 SF1 SF3B5 DHX8 PRKRIP1 SF3B2 CWF19L2 SF3B3 WDR70 ISY1;ISY1-RAB43 DHX35 SF3B6 PRPF38A SF3B1 SMU1 SF3A3 NKAP UBL5 SF3A1 GCFC2 SF3A2 PRPF18 XAB2 SDE2 PHF5A FAM32A CACTIN PRPF31 RBMX2 TXNL4A SNIP1 SNRPN SNW1 IK PRPF4B CHERP LENG1 LSM5 PRPF4 LSM4 PRPF3 SNRNP27 LSM3 ZMAT2 LSM2 CCDC12 YJU2 LSM8 LSM7 LSM6 NSRP1-1 PTBP1 PPWD1 USP39 PLRG1 SART1 TFIP11 SNRPA1 SYF2 DNAJC8 LUC7L3 C9orf78 PUF60 WBP4 SNRPB2 RNF113A MFAP1 SNRNP40 RBM42 BUD13 FAM50A PPIL3 PPIL4 SRRM2 DDX5 AQR CRNKL1 PRPF19 HNRNPH1 HNRNPH2 SAP18 CWC25 PPIL1-1 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 U2AF1L5;U2AF1 EIF4A3 CASC3 CDC40 SRRM1 DDX39B SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A SRSF1 U2AF2 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 ALYREF UPF3B RNPS1 SNRPD2 SNRPD1 SNRPD3 HSPA8 SNRPF POLR2A SNRPB POLR2B POLR2C SNRPE-2 POLR2D POLR2E SNRPG-2 POLR2F POLR2G POLR2H POLR2I POLR2L GTF2F1 GTF2F2 POLR2J;POLR2J2;POLR2J3 MTREX SNU13 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome PTPN11 HBEGF PIK3R1 EGFR PAG1 PIK3CA SRC GAB1 TGFA EGF PXN CSK AREG EREG BTC EPGN NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor NELFB NTRK3 BAX DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA EGF AREG G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG5 GNB1 GNG4 GNB4 GNB3 GNG8 GNB5 PLCB3 PLCB1 PLCB2 GNG13 GNGT1 GNG10 GNB2 GNG2 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system H2BC21 H2BC15;H2BC3;H2BC11;H2BC12 SERPING1 H2AC4 H2AZ2;H2AZ1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 HRG A2M PRCP H2AC20 F12 H2AC14 PLAUR C1QBP KLKB1 H2AB2;H2AB3;H2AB1 KRT1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KNG1 H2BC5 H2BC1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SUMO3 SUMO2 UBA2 SAE1 SUMO1 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) FGB S100A1 FGA CD36 TIRAP S100A9 FGG TLR4 S100A8 LY96 TLR1 TLR6 HMGB1-1 TLR2 BTK MYD88 CD14 IRAK4 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 SFTPD SFTPB CSF2RB CSF2RA SFTPC PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection RAC1 VAV1 HCK ELMO1 CYFIP2 WIPF1 WIPF2 WIPF3 BTK NCKIPSD FCGR3A;FCGR3B VAV3 MYH9 MYO5A ARPC4 ARPC5 PTK2 ARPC2 ARPC3 MAPK1 ACTR3-1 ARPC1B VAV2 ARPC1A WASL MAPK3 ACTR2 SYK FGR ACTB-1 NCKAP1 WASF1-1 WAS CDC42 CRK ACTG1 NCK1 FYN WASF3 MYO10 CYFIP1 MYO1C NCKAP1L WASF2 LYN MYO9B ABL1 BAIAP2 YES1 ABI2 ABI1 ELMO2 CD3G DOCK1 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling SEMA3A CDK5 CDK5R1 DPYSL4 DPYSL5 DPYSL3 PLXNA1 PLXNA4 NRP1 DPYSL2 PLXNA2 FES FYN PLXNA3 GSK3B CRMP1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins PROC F7 GAS6 FURIN F9 F10 PROS1 F2 GGCX DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD VCAN CHST3 CSPG5 CSPG4 NCAN BGN DCN BCAN SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants CEBPB BCL2A1 RNF213-2 MAPK9 MAPK8 VCL RANBP2 AGO3;AGO1 SKP1 FRS3 CARS1 JUN PLCG1 UBA52 STAT1 STAT3 HDAC1 CCNB1 EEF1G CUL1 RPS6 SQSTM1 ATIC RB1 CDKN1A RPS27A UBB;UBC IL10RA RBX1 TP53 STAT5A PPFIBP1 IL10 KIF5B GRB2 MYH9 TPM4 CLTC TPM3 PIK3CB MAPK1 TYK2 TFG MAPK3 PRF1 LMO7 FOXM1 FRS2 ICOS IRS1 ZC3HC1 PIK3CA DCTN1 WDCP ALK NPM1-2 GCC2 EML4 FN1 PPM1B HIP1 BCL11A PRKAR1A GZMH;GZMB-1 EIF2AK3 STRN BIRC6 TPR MDM2-2 SEC31A TNRC6C PIK3R2 PIK3R1 PTPN6 MOV10 AGO4 KLC1 AGO2 MCL1 JUNB DNMT1 RRBP1 ZAP70 IRF4 MSN IL22 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib CDC37 HSP90AA1 ERBIN ERBB2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade DUSP6 TAB2 DUSP7 TAB1 TLR10 TLR5 LRRC14 MAPK9 USP14 MAPK8 NLRX1 MAPK7 RPS6KA1 PELI3 IKBKB PELI2 FOS NLRC5 NOD1 NOD2 AGER IRAK2 IKBKG S100A12 MAPK10 BTRC N4BP1 MAP3K7 MAP3K1 SKP1 TNIP2 CHUK USP18;USP41 FBXW11 APP JUN ELK1 UBA52 CUL1 RELA MAP3K8 RPS27A UBB;UBC NFKB1 TP53 NFKBIA NFKB2 TIFA ALPK1 NFKBIB MAP2K2;MAP2K1 MAPK1 MAPK3 PPP2R1B MAPK14 PPP2R1A MAPK11 CASP8 MAPKAPK3 IRAK1 MAPKAPK2 RPS6KA3 RPS6KA2 RPS6KA5 MAP2K3 MAP2K4 TRAF2 ATF2 PELI1 MAP2K7 MAP2K6 PPP2CB;PPP2CA HMGB1-1 RIPK2 MYD88 ATF1 ECSIT PPP2R5D SAA2;SAA1 NKIRAS1 TRAF6 NKIRAS2 IKBIP UBE2V1 DUSP4 MEF2C MEF2A DUSP3 IRAK4 UBE2N VRK3 TAB3 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC GLI1 SKP1 PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 NUMB PRKACA-1 PSMB1 PRKACB-1 RPS27A UBB;UBC ADRM1 RBX1 PSMA2-1 SEM1 ITCH PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi MAN2A2 ST8SIA6 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 MGAT4A-1 ST8SIA3 FUT8 MAN2A1 MGAT5 ST3GAL4 MGAT2 ST6GAL1 MGAT4C MGAT4B B4GALT6 MGAT3 B4GALT4 FUT6;FUT5;FUT3 FUCA1 B4GALT5 CGA CHST8 CHST10 LHB TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript NUP107 NCBP2-1 NUP43 EIF4E RANBP2 CPSF2-1 CPSF1 CPSF3 NUP205 NUP188 NXF1 WDR33 AAAS NUP42 NUP62 NUP160 TPR SYMPK NUP88 RAE1 ALYREF FIP1L1 NUP85 NDC1 NUP214 NUP37 NUP210 NUP155 NUP153 NUP93 NUP50 POM121;POM121C NUP35 NUP54 CPSF4 SEC13 NUP133 NCBP1 SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT RAC1 AMER1 SOX9 H2AJ CSNK2A1;CSNK2A3 AGO3;AGO1 TLE1 KLHL12 YWHAZ HECW1 H2BC5 HDAC1 H2BC1 H2AC4 RUNX3 CAV1 TCF7 CTNNB1 GSK3B DPY30 H2BC21 GNAT2 WDR5 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 H2AZ2;H2AZ1 PLCB2 NLK PDE6B PDE6A GNAO1 LEF1 SMURF2 SMURF1 RBBP5 SOX17 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TCF7L2 TCF7L1 TNRC6A-1 TNRC6C H2BC15;H2BC3;H2BC11;H2BC12 AXIN1 TNRC6B XPO1 EP300 TERT CREBBP ARRB2 PPP3CA PPP3CB WNT5B ROR1 PPP3R1 ROR2 NFATC1 CALM3;CALM1 VANGL2 AXIN2 APC DAAM1 RBX1 WNT2B GNGT1 KMT2B TRRAP SOX3 FRAT2 WNT5A SOX6 WNT9B SOX7 SOX4 WNT9A RNF43 WNT16 RYK-1 CTNNBIP1 SOX13 CTBP2 CSNK1A1 WLS DKK1 CTBP1 TPTEP2-CSNK1E;CSNK1E DKK2 DKK4 PYGO1 PYGO2 VPS29 SFRP1 VPS35 SFRP2 RHOA TMED5 CSNK1G2 PARD6A BCL9L BCL9 CCDC88C VPS26A WNT8A CHD8 RAC3 WNT8B USP34 CBY1 RSPO2 SOST RSPO1 WNT6 GNG10 RSPO4 KREMEN1 WNT11 KREMEN2 PRICKLE1 LRP5 GNG2 LRP6 GNG5 ZNRF3 GNG4 WIF1 GNG8 WNT1 SRY LGR6 WNT2 LGR5 LGR4 WNT3 WNT4 FZD1 WNT10B XIAP WNT10A FZD3 FZD2 FZD5 FZD4 WNT3A WNT7B FZD7 FZD6 FZD8 WNT7A GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 TLE5 CUL3 AP2A1 AP2A2 AP2M1 SMARCA4 AP2S1 DVL1 TLE4 DVL2 AP2B1 TLE2 DVL3 CAMK2A ITPR1 ITPR2 TLE3 CLTC CLTA ITPR3 PFN1 PPP2R1B PPP2R1A SNX3 TNKS TNKS2 RNF146 PPP2CB;PPP2CA PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C PIP5K1B PSMD8 PSMD6 USP8 PSMD7 PSMD2 PSMD3 PSMD1 BTRC MAP3K7 SKP1 PRKCB PSMC2-1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBA52 SCRIB PSMD12 PSMD11 PSMD14 PRKCG PSMD13 CUL1 SOX2 PSMA7 PSMB6 RSPO3 PSMB7 PSMB4 CLTB PSMB5 PSMB2 PSMB3 PSMB1 RPS27A UBB;UBC ADRM1 PSMA2-1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RUVBL1 ZRANB1 CDC73 LEO1 PORCN H2AC14 AKT2 MYC MEN1 AKT1 KAT5 CSNK2A2 CSNK2B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MOV10 AGO4 H2AC20 AGO2 H2AB2;H2AB3;H2AB1 ASH2L GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP11B1;CYP11B2 CYP21A2 SRD5A1 AKR1D1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CBR1-1 BENZENE METABOLISM%WIKIPATHWAYS_20260410%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH CYP2E1 GSTM1;GSTM2-1 MPO NQO1 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260410%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACAA2 ACADL ECI1 EHHADH-1 ACSL3 HSD17B10 ACADSB DECR1 MAPK CASCADE%WIKIPATHWAYS_20260410%WP422%HOMO SAPIENS MAPK cascade ARAF ELK1 NRAS MAP2K2;MAP2K1 RRAS MAP2 MAPK1 MBP MAP2K7 HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 MAP3K3 JUN MAP3K1 BRAF MAPK14 MAPK12 MAPK10 PLCB3 RASA3 GRB2 KRAS SOS1 RAF1 LAMTOR3 SOS2 SIPA1 MAP3K12 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260410%WP585%HOMO SAPIENS Interferon type I signaling MAP2K6 MAP2K3 MAP3K1 MAPK14 EIF4A1 IRS1 PIK3CD IRS2 CRKL RPS6KA4 RPTOR RPS6KA5 RACK1 MLST8 RAC1 JAK1 IFNAR2 PIAS3 PRMT1 RPS6 GAB2 TYK2 VAV1 PIAS1 ZAP70 CREB1 LCK RAPGEF1 CRK IRF9 IFNAR1 MAPKAP1 PIK3R2 PIK3R1 CBL SOCS3 RAP1A SOCS1 STAT4 EIF4EBP1 FYN EIF4E EIF4B STAT5A STAT1 STAT2 STAT3 PTPN11 MTOR PTPRC RPS6KB1 PDCD4 REL PTPN6 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260410%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle FH MDH2 IDH3G IDH2 DLST SDHC SDHD SDHA SDHB CS SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 DLD IDH3A FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260410%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CASP8 CASP10 CASP6 CASP3 ARHGDIB LMNA FADD PAK2 SPTAN1 MAP3K7 DFFB DFFA DAXX PARP1 APAF1 RIPK2 CFLAR ACTA1 IL1A MAPKAPK3 NFX1 ACTB-1 MAPKAPK2 BCL2 FAS SMIM40 MAP2K4 JUN MAP3K1 RB1 PRKDC FAF1 HSPB1 FASLG TNF LMNB2 ACTG1 LMNB1 CASP9 CYCS-1 CASP7 PAK1 MAPK8 ATR SIGNALING%WIKIPATHWAYS_20260410%WP3875%HOMO SAPIENS ATR signaling TOPBP1 RAD9B ATRIP ATR RAD9A RPA3 CHEK1 RPA1 HUS1 RPA2 RAD1 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260410%WP4318%HOMO SAPIENS Mitochondrial fission and fusion FIS1 MTFP1 BNIP3 PHB PLD1 MIB1 OPA1 MFN1 BAX MFN2 DNM1L SH3GL2 BCL2L1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260410%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 CASP8 CASP6 MAPK10 CASP3 FADD APAF1 HSPA1A;HSPA1B NFKB1 TNFRSF1A AIFM1 FASLG CASP2 RIPK1 FAS BID CASP9 CYCS-1 CASP7 MAP3K1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260410%WP4842%HOMO SAPIENS Mammalian disorder of sexual development RSPO1 PTGDS INSL3 AMH WNT4 EMX2 RBFOX2 DMRT1 CBX2 FST FOXL2 PBX1 NR5A1 MAPK11 WT1 CTNNB1 FGFR2 AMHR2 DHH GATA4 SRD5A1 FGF9 SOX8 SOX9 SRY THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260410%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK BCKDHA PDHA1 SLC25A19 TPK1 SLC19A3 TKT SLC19A2 OGDH PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260410%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCD3 PLCD4 PLCB2 PLCD1 PI4K2A PI4K2B MTMR1 MTMR2 MTMR8 PTEN PIK3C2G PIK3CB PIK3C2A PIK3CG MTMR6 PIK3C2B MTM1 PLCB3 PIP4P2 PIP4P1 INPP5D INPP5E PLCG2 PIP5K1A PLCE1 INPP5K PIP4K2A PIP4K2B PIP5K1B PIK3CD PIP5K1C PLCG1 PIP4K2C SACM1L IPMK TPTE;TPTE2 OCRL INPP4A FIG4 INPP4B PIKFYVE PLCB4 PIK3CA PI4KA PI4KB PLCB1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260410%WP704%HOMO SAPIENS Methylation pathways PNMT NNMT TPMT MAT2A MAT1A MAT2B HNMT COMT INMT HEDGEHOG SIGNALING%WIKIPATHWAYS_20260410%WP47%HOMO SAPIENS Hedgehog signaling PTCH1 PTCH2 IHH KIF7 GLI1 GLI3 ARNTL GLI2 SHH GRK2 SMO SIN3A DHH STK36 SAP18 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation MAPK11 IHH MAP2K2;MAP2K1 MAPK1 STAT1 MAPK3 CDKN1A CNP THRA PPP2CB;PPP2CA NPR2 PTH1R MAPK14 PTHLH MAPK12 ATG5 MAPK13 BMP4 BMP2 RBL1 FGF18 SNAI1 RAF1 FGFR3 FGF9 SOX9 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260410%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress IL1A BCL2 CHEK1 MAP2K3 CDKN1A MAP2K4 MAPK14 ATR ATF2 CXCL8 KEAP1 ICAM1 IKBKB AKT1 IKBKG BCL2L1 MAP3K5 TSC1 NFKB1 FOXO1-1 RPS6KA5 FOS IPCEF1 SIRT1 CCNE1 CAT TP53 PTGS2-2 CUL3 MDM2-2 NRF1 PIP-1 HMOX1 GSX1 NOS2 CREB1 SOD2 IL6 PINK1 RHEB CDK2 NOX1 NFE2L2 MTOR PTEN TNF PIK3CA MAPK8 NQO1 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260410%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials PORCN CREBBP LRP5 LRP6 CTNNB1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation IL1A FOS VAV1 IL6 CSF3 CIITA CSF2 SPI1 THRB TRAF3IP3 CSF1 EPO STAT5A ITGB3 ITGA2B IKZF1 LYL1 HMGN5 TRIM29 MYB PIM1 CD34 KCNH2 HES6 LMO2 RHOH RUNX1 IL1B IRF5 NOTCH1 TNXB LEF1 CXCR4 GATA2 ACVR1B GATA1 SEC14L2 MUC1 TPO MXI1 NCKAP1L NFE2 RIOK3 NFATC2 FLI1 KLF1 GP9 IL3 KITLG IL5 FOSB UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260410%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UXS1 GFPT1 PGM3 HK2 PGM1 GCK HK1 HK3 UGDH GPI GALE DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260410%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte CEBPA CEBPB CEBPG HSPB7 SLC7A10 PLAC8 ZIC1 PRDM16 HOXC9 ZNF423 PPARGC1A HOXC8 PPARGC1B MPZL2 SMAD1 EBF3;EBF1 ADIPOQ CIDEA SMAD9 BMP7 SMAD5 LEP PPARG BMP4 BMP2 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260410%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PKM SLC16A1 SLC2A1 PFKP PDK1 HK1 PDP1 LDHA TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260410%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IL6 MAP3K7 TRAM1 TBK1 IRAK1 INPP5D IKBKE IFNB1-4 CHUK IRAK3 CXCL8 IRAK4 TICAM1 TIRAP IKBKB NFKBIA IRF3 IKBKG TRAF3 TRAF6 NFKB1 IRF7 TAB2 TAB1 TLR4 TNF RIPK1 MYD88 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes LDLR ABCA1 MYLIP STARD3 OSBPL5 ACSL1 SORT1 ACSL6 ACSL5 APOA4 ACSL3 FABP1 FABP2 FABP3 FABP4 SOAT1 STAR SOAT2 NPC2 APOC2 APOC1 VDAC1 SLC27A3 SLC27A2 SLC27A4 SCARB1 SLC27A1 LRP1 PCSK9 LIPA APOE LDLRAP1 APOB SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC3 SMC1A RAD18 MDC1 RAD50 PAXIP1 MRE11 RAD21 ATM NBN BRCA1 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260410%WP2374%HOMO SAPIENS Oncostatin M signaling CASP3 CEBPB MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 MAPK14 GRB2 KRAS SOS1 RAF1 IRS1 NFKBIA AKT1 NFKB1 FOS JAK1 PIAS3 RPS6 TYK2 CREB1 CDK2 PIK3R1 SOCS3 STAT1 STAT3 PTPN11 MTOR CDKN1B JAK2 JAK3 JUNB PRKCH PRKCB PRKCE PRKCD PRKCA LIFR OSMR IL6ST SRC PXN HIF1A RELA MAPK9 PTK2B RICTOR EGR1 STAT5B JUND OSM VEGFA SHC1-1 CASP7 MAPK8 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260410%WP1971%HOMO SAPIENS Integrated cancer pathway CASP8 MYC CHEK2 SMAD2;SMAD3 CASP3 E2F1 BARD1 CDKN2B POU2F1 MMP1 CDK2 BAD PLK1 CDC25A CDC25B MSH6 MSH2 CDK4 NOXA1 CDK1 STAT1 BCL2 RAD50 MRE11 CHEK1 CDKN1A PTEN ATM BRCA1 CDKN1B ATR BAX AKT1 RB1 MAP3K5 JAK1 TP53 CASP9 ATF1 BLM MDM2-2 BACH1 BBC3 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260410%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR ABCA1 SREBF1 PPARGC1A PRKAA1 NR1H3 SIRT6 HMGCR MED15 SIRT1 SREBF2 HMGCS1-1 SCD MTOR FASN PPARA 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome NIPA1 TUBGCP6 TUBGCP3 TUBGCP4 NIPA2 CYFIP1 TUBGCP2 FMR1 TUBGCP5 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260410%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling CDK4 MAP2K2;MAP2K1 MAPK1 HRAS MAP2K6 MAPK3 MAP2K3 BRAF MAPK14 IGF1R CCND3 RPS6KA1 TSHB PDPK1 RAF1 PLD1 SCRIB GNAS-1 RBL2 GNAI3 ADCY3 ADCY2 AKT1 RAP1GAP GNAI1 GNAI2 MYL12B GNA13 RAP1B GNG2 GNA12 CCNE1 CGA JAK1 RALGDS PDE4D-1 KCNIP3 TSHR RPS6 GNAO1 APEX1 GNAQ GNB1 CREB1 CDK2 PIK3R2 PIK3R1 RAP1A STAT1 STAT3 MTOR RPS6KB1 CDKN1B JAK2 SRC RB1 PIK3CA PLCB1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP561%HOMO SAPIENS Heme biosynthesis ALAD ALAS2 ALAS1 FECH UROD UROS HMBS CPOX PPOX ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260410%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD MYC E2F1 CDK2 NFE2L2 RET LPL AHR EGFR HPGDS PLAGL1 NRAS NRIP1 MAP2K2;MAP2K1 CYP1B1 EP300 CCL1 MAPK1 CD36 FGF21 HSP90AA1 HRAS AIP ARNT ESR1 NCOR2 KLF6 CDKN1A GCLC PSRC1 CDC37 CYP1A2 NF1 CYP1A1 AHRR CDKN1B NCOA7 KRAS RAF1 SRC RB1 RELA NFKB1 TNF VEGFA PTGS2-2 NQO1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260410%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL2 MYL3 TNNT3 MYH8 TCAP VIM MYH6 ACTA1 MYOM1 ACTC1;ACTG2 TNNI1 TNNI2 DMD TNNI3 MYBPC3 TMOD1 MYBPC1 MYBPC2 ACTN3 TPM4 TPM3 ACTN2 TPM2 TNNC1 TNNC2 TPM1 NEB ACTN4 MYL4 ACTG1 ACTA2 MYH3 DES TNNT1 TTN-1 MYL1 TNNT2 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260410%WP5193%HOMO SAPIENS Cholesterol synthesis disorders IDI1 FDPS MVK CYP51A1 DHCR24 MSMO1 LSS SQLE EBP HSD3B1;HSD3B2 PMVK SC5D MVD DHCR7 HMGCR LBR FDFT1 HMGCS1-1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260410%WP2324%HOMO SAPIENS AGE RAGE pathway CASP8 SMAD2;SMAD3 CASP3 MAP2K2;MAP2K1 MAPK1 NCF1 INS;INS-IGF2 LGALS3 MAPK3 MMP7 MMP2 PLA2G4A MMP9 RHOA JUN DDOST MMP14 MMP13 MAPK14 EZR ROCK1 FOXO4 AGER PRKCZ CDC42 MSR1 RAF1 NOS3 CHUK INSR ATF2 MSN IRAK4 INHBB SOD1 TIRAP DIAPH1 IRS1 IKBKB NFKBIA SP1 AKT1 ALPL NFKB1 FOXO1-1 MYD88 RAC1 NOS2 EGFR STAT5A STAT1 STAT3 JAK2 PRKCB PRKCD PRKCA SRC HIF1A RELA MAPK9 STAT5B CASP9 SHC1-1 CYCS-1 MAPK8 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260410%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MYC CDH1 CHI3L1 E2F1 STAT3 TP53 SOCS3 BAX MMP9 IL6ST STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP496%HOMO SAPIENS Steroid biosynthesis HSD3B1;HSD3B2 HSD17B1 HSD17B2 HSD17B3 HSD17B4 F13B HSD17B7 CYP17A1 CPN1 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260410%WP4496%HOMO SAPIENS Signal transduction through IL1R TGFB1 TGFB3 IL1R1 TOLLIP IL6 MAP3K14 MAP3K7 IL1A MAP2K6 MAP2K3 JUN MAP3K1 MAPK14 IL1B IRAK1 IFNB1-4 CHUK IRAK3 IKBKB NFKBIA RELA TRAF6 NFKB1 TAB1 TNF MYD88 IL1RN IL1RAP ECSIT IRAK2 MAPK8 TGFB2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway GGPS1 IDI2 IDI1 ACAT2 FDPS ACAT1 MVK HMGCL PMVK MVD HMGCR FDFT1 HMGCS1-1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260410%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling BAD GSK3B TCF7 CREBBP PDGFA CCND1 CREB3L1 AKT3 CTNNB1 KLK3;KLK2 MAP2K2;MAP2K1 PDGFRB AR MAPK1 BCL2 MTOR CDKN1A CDKN1B GRB2 KRAS SOS1 RAF1 NFKBIA IKBKG NFKB1 FOXO1-1 TP53 CASP9 PIK3CA MDM2-2 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260410%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PLCB2 AMH STAR NRAS HSD3B1;HSD3B2 MAP2K2;MAP2K1 ARRB1 ARRB2 MAPK1 BMP15-1 CYP11A1 AKT2 HRAS KISS1R MAPK3 PRKCG KISS1 GDF9 FSHR MMP9 PRKCQ PIK3CB PIK3CG PDK1 PLCB3 PRKCH KRAS PRKCB PRKCE RAF1 PRKCD PRKCA PIK3CD AKT1 NFKB1 PLCB4 PIK3CA PLCB1 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260410%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TGFB1 TGFB3 SMAD2;SMAD3 EGFR CTNNB1 NRAS HRAS MTOR TGFA TGFBR1-1 TSPAN8 ERBB2 PROM1 SMAD4 WNT3A HGF WNT5A AXIN1 KRAS TGFBR2 DKK4 RAF1 TGFBR3 APC MFGE8 MET AKT1 TGFB2 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer MYC AXIN2 WNT16 SENP2 DKK1 DKK2 SFRP4 SFRP1 SFRP2 SFRP5 MAP3K7 CSNK2B ROR1 ROR2 CSNK2A1;CSNK2A3 ATF3 CTBP2 CTBP1 MACROH2A2 NLK CXXC4 NKD1 NKD2 WNT6 WNT11 WIF1 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 FZD1 JUN TFAP2A WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 CCND3 FZD5 CSNK1A1 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A FOSL1 CDK8 HNRNPK CDK6 TPTEP2-CSNK1E;CSNK1E NOTUM EZH2 WNT4 GSK3B PORCN TCF7 LRP5 CCND1 LRP6 CTNNB1 WNT3A WNT5A AXIN1 LEF1 DKK4 APC WNT2B CHD8 HNRNPU FZD10 FRAT2 CCND2 SOX17 PLAU RUVBL1 SOST CER1 APC2 WNT5B RYK-1 SERPINF1 CSNK2A2 CTNNBIP1 KREMEN1 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260410%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system XPO1 XPO4 IGF2BP1 EIF5A;EIF5AL1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260410%WP5087%HOMO SAPIENS Pleural mesothelioma LIN28B EFNA2 FGF14 FGF19 FGF13 FGFR4 FGF12 FGF11 FGFR1 FGF10 LAMC3 YWHAB LAMC2 LAMC1 RB1CC1 ELK1 CASP1 KDM6A MAP2K2;MAP2K1 EED MMP3 TTI1 LATS1 MAPK1 LATS2 MAP2K7 CDH10 HRAS AKT1S1 MAP2K6 CDH11 CDH12 MAPK3 MAP3K2 CDH13 MAP2K3 CDH15 MAP2K4 CDH16 MAP3K3 CDH17 JUN CDH18 MAP3K1 CDH19 LAMA5 LAMA2 MAPK14 LAMA1 LAMA4 MAPK10 LAMA3 SLC3A2 GRB2 RNF2 MAPK7 SOS1 MKNK1 RAF1 MKNK2 LAMB3 EGF LAMB2 LAMB1 RPS6KB2 TEK PIK3CD RPTOR RPS6KA5 MLST8 JAK1 RPS6 CREB1 EIF4EBP1 EIF4B STAT1 MTOR RPS6KB1 ACTG1 CYCS-1 PAK1 MAPK8 PAK2 ACTA1 ACTB-1 MAPKAPK2 BCL2 BAX NFKB1 FGF9 WNT4 CTNNB1 FGFR2 PTEN PIK3CB PIK3CG PLCB4 PIK3CA CDKN1A FGF18 FGFR3 ATF2 AKT1 MAP3K5 TSC1 FOXO1-1 CCNE1 TP53 MDM2-2 IL6 RHEB CDK2 PORCN LRP5 LRP6 CSF3 CSF2 CSF1 ITGB3 IL1B LEF1 KITLG PPARGC1A SLC2A1 PDK1 FABP4 ATM BRCA1 SRC HIF1A MAPK9 VEGFA SHC1-1 BBC3 MYC E2F1 BARD1 CDK4 PRKAA1 IGF1R CCND3 RPS6KA1 EGFR FGF21 ACTC1;ACTG2 ACTA2 TNNT1 INS;INS-IGF2 MMP2 MMP9 MMP14 AGER INSR SP1 CDH1 TGFB1 GSK3B TCF7 PDGFA CCND1 AKT3 PDGFRB AKT2 TGFA WNT3A HGF WNT5A AXIN1 DKK4 APC MET WNT2B CHD8 FZD10 FRAT2 CCND2 SOX17 PLAU SOST CER1 WNT5B RYK-1 SERPINF1 CSNK2A2 KREMEN1 WNT16 SENP2 DKK1 DKK2 SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B ROR1 ROR2 CSNK2A1;CSNK2A3 ATF3 CTBP2 CTBP1 CXXC4 WNT6 WNT11 WIF1 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 FZD1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 CSNK1A1 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A FOSL1 TPTEP2-CSNK1E;CSNK1E NOTUM EZH2 PRKAB2 ATG13 PRKAB1 HCFC1 DDIT3 IDO1 CCL13;CCL2 PDGFB TERT PDGFD PDGFC OGT-1 NGFR PHC1 FN1 MOB1A;MOB1B SETD5 SETD2 PRKAG1 PRKAG2 AREG PRSS23 PRKAG3 TEAD1 TEAD2 TEAD3 TEAD4 RING1 CXCL2;CXCL3;CXCL1-1 CIT SLC7A5 PIGF HBEGF NTF4 CCL4L2;CCL4L1;CCL4 NTF3 HMGB1-1 MEF2D CDKN2A FGF1 FGF2 CDH9 CDH8 FGF3 CDH7 FGF4 CDH6 FGF5 YY1 CDH5 FGF6 CDH4 FGF7 FGF8 CDH3 DEPTOR CDH2 MAP3K9 MAP3K6 MAP3K4 HMGN1 LGALS9C;LGALS9;LGALS9B PGF TNIK AJUBA MAD1L1 DSC3 CD274 CSF1R MAX KMT2C CUL1 ITPR3 SAV1 BAG2 MAP2K5 MCL1 BDNF CXCL10 CDK7 CXCL12 MAP3K10 MDM4 NF2 MCU MAP3K11 EIF4G1 ITGB1 FLT1 ITGB4 FLT3 FLT4 ITGB2 FOXM1 ADAMTS1 MDK WDR5 ITGAV ITGA4 ITGA3 ITGA2 ITGA1 TRAF2 NGF ITGA6 BECN1 PRKAA2 UHRF1 RBBP4 YAP1-1 CCL5 BAK1 CTHRC1 NTRK1 NTRK2 ANGPT4 ANGPT2 ANGPT1 ASXL1 SPARC RPS6KA3 RASSF1 RASSF2 RASSF3 RASSF4 RASSF5 RASSF6 KDR CXCL5;CXCL6 CCN2 BTRC FLT3LG BTC ULK2 ULK1 TELO2 EPHA2 STK38L WWTR1 SETDB1 IGF2 RASSF7 IGF1 PTK2 BAP1 LIMD1 BMI1 GABPA MAP4K1 IL10 MAP4K2 MINK1 MST1 KIF23 KIT CD47 VGLL4 CD44 CTNNA1 CTNNA3 CTNNA2 PAK3 PAK5 MAP4K3 PAK4 MAP4K4 SUZ12 IL34 VEGFB VEGFC VEGFD MAD2L1 WWC1 BUB1B-PAK6;PAK6 AMOT PDGFRA TSC2 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 EFNA5 EFNA4 NDRG1 STK3 PODXL CDH20 CDH22 FGF20 CDH24 NLRP3 FGF23 FGF22 SELE EFNA1 FGF17 EFNA3 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260410%WP3287%HOMO SAPIENS Overview of nanoparticle effects HMOX1 LAMA3 IL6 CCND3 FN1 PTK2 COL4A1 CXCL8 BAX CDH3 AKT3 CRP PIK3CD PTGS1 ITGAD NFRKB TNF BCL2 PTGS2-2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP4149%HOMO SAPIENS White fat cell differentiation KLF5 IRF4 RARA CREB1 CEBPA CEBPB ZNF423 SREBF1 NR1H3 STAT5A CTNNA1 INS;INS-IGF2 PPARG WNT10B TCF7L1 GATA2 IRF3 CEBPD FOXO1-1 RORA GATA3 NR3C1 STAT5B MECOM TLE3 EGR2 EBF1 NR2F2 KLF4 DDIT3 KLF15 KLF2 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEX16 ARSA PEX19 PEDS1-UBE2V1;PEDS1 GAL3ST1 LPCAT1 PEX1 ALDH3A2 UGT8 GNPAT PEX7 PEX5L PEX3 AGMO DGKQ DHRS7B AGPS FAR1 FAR2 CEPT1 LPIN1 ACAD10 LPIN2 LPIN3 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260410%WP4463%HOMO SAPIENS Steroidogenic pathway HSD3B1;HSD3B2 HSD17B1 CYP11A1 CYP17A1 CYP19A1 STAR BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260410%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 CYP1A1 CYP1B1 AKR1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260410%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing RNASEH2A DDX58 RNASET2 TREX1 CGAS ADAR SAMHD1 IFIH1 MAVS IFNB1-4 STING1 OAS1 IRF3 RNASEH2C RNASEL RNASEH2B CHEMOKINE SIGNALING%WIKIPATHWAYS_20260410%WP3929%HOMO SAPIENS Chemokine signaling PLCB2 NRAS MAP2K2;MAP2K1 MAPK1 GRK2 HRAS MAPK3 BRAF PLCB3 GRB2 KRAS SOS1 RAF1 SOS2 GNAI3 ADCY3 IKBKB ADCY2 AKT1 PIK3CD IKBKG GNAI1 CRKL GNAI2 RAP1B GNG2 RAC1 GNB1 VAV1 CRK PIK3R2 PIK3R1 RAP1A CCL1 CXCL2;CXCL3;CXCL1-1 STAT1 STAT2 STAT3 CCL4L2;CCL4L1;CCL4 CXCR4 CXCL13 CXCL14 PREX1 PF4;PF4V1-1 TIAM2 TIAM1 ADCY9 PARD3 ELMO1 CCL3L1;CCL3L3;CCL3;CCL18 SHC4 SHC2 SHC3 PIK3R3 RASGRP2 FOXO3 PIK3R5 GRK1 GNG10 GRK5 PAK1 GRK4 GRK6 CCR10 LYN CCR1 XCR1 XCL1;XCL2 PPBP GNG13 CXCL10 CXCL11 CXCL12 GNB2 GNB4 GNB3 GNB5 NFKBIB ITK CXCL9 WASL CX3CL1 GNGT1 CCL23;CCL15 CCR9 CCR8 CCR7 NCF1 CCR6 CCR4 CCR3 CCR2 VAV3 VAV2 FGR HCK DOCK2 CX3CR1 CCL11 ROCK2 ROCK1 ADCY4 CXCR5 WAS PRKCZ PRKX ADCY1 CDC42 CCL5 CXCR6 ADCY8 CHUK ADCY7 ADCY6 ADCY5 PRKACB-1 GNG5 NFKBIA GNG4 CXCR3 CXCR2 GNG8 NFKB1 CSK CCL19 CCL17 CCL25 CCL24 CCL22 CXCL5;CXCL6 CCL21 CCL20 CCL28 CCL27 BCAR1 CCL26 PTK2 GSK3B AKT3 ARRB1 ARRB2 AKT2 PIK3CB PIK3CG JAK2 JAK3 PRKCB PRKCD PXN RELA PTK2B STAT5B PLCB4 SHC1-1 PIK3CA PLCB1 CANCER PATHWAYS%WIKIPATHWAYS_20260410%WP5434%HOMO SAPIENS Cancer pathways GSTM1;GSTM2-1 FGFR4 FGFR1 LAMC3 LAMC2 LAMC1 ARAF ELK1 NRAS MAP2K2;MAP2K1 MMP3 MAPK1 HRAS MAPK3 JUN BRAF LAMA5 LAMA2 LAMA1 LAMA4 MAPK10 PLCB3 LAMA3 GRB2 KRAS SOS1 RAF1 LAMB3 SOS2 EGF LAMB2 LAMB1 RPS6KB2 PIK3CD CRKL RPS6KA5 MECOM RAC1 JAK1 IFNAR2 RARA CRK IFNAR1 PIK3R2 PIK3R1 CBL STAT4 STAT5A STAT1 STAT2 STAT3 MTOR RPS6KB1 FH ADCY9 RB1 FASLG PIK3R3 RASGRP2 CASP9 CYCS-1 GNG10 CASP7 MAPK8 CASP8 CASP3 FADD GNG13 GNB2 GNB4 GNB3 GNB5 APAF1 GNGT1 BCL2 FAS ROCK2 ADCY4 ADCY1 ADCY8 PLD1 ADCY7 ADCY6 ADCY5 PRKACB-1 BAX GNG5 GNG4 BCL2L1 GNG8 NFKB1 BID TFG DAPK2 DAPK3 BCR EML4 AGTR1 WNT4 JAG2 GSTM4 GSTM3 JAG1 JUP FZD4 HEY1 HEY2 ELOB CCNA2-1 APPL1 CTNNB1 GSTO2 FGFR2 IFNGR1 GSTO1 IFNGR2 WNT9B WNT9A F2 DDB2 PAX8 RARB PPARD GSTP1 WNT8A WNT8B PTEN STAT6 IL12RB1 PIK3CB RUNX1T1 IL12RB2 EGLN1 EGLN3 EGLN2 AGT HEYL CCDC6 CSF3R PLCG2 IL5RA PIM2 IL13RA1 F2R MITF RBX1 MSH3 NOTCH2 PLCG1 NOTCH3 NOTCH4 CUL2 KNG1 HSP90B1 BCL2L11 TPR ABL1 ZBTB17 ZBTB16 PLCB4 NFKB2 ALK PIK3CA HSP90AB1 ELOC-1 PLCB1 NKX3-1 PLEKHG5 TRAF1 PLCB2 GSTT2B;GSTT2 TRAF4 TRAF5 IL3RA BIRC5 CCDC42 BIRC7 BIRC2 BIRC3 HDAC2 HDAC1 IL2RG E2F2 PTCH1 E2F3 PTCH2 TXNRD3 TXNRD2 KIF7 GLI1 TXNRD1 GLI3 PML RAD51 GLI2 IL2RA SHH IL2RB CALML6 SMO HHIP CALML3 CALML4 EDNRA CDKN1A EDNRB IL12B IL12A SKP2 SKP1 IL23A EPAS1 MGST3 LPAR1 MGST1 BMP4 MGST2 BMP2 LPAR2 LPAR3 LPAR4 GADD45B FGFR3 GADD45A GADD45G CXCL8 KEAP1 LPAR5 LPAR6 IKBKB GSTA3;GSTA5;GSTA1;GSTA2 AKT1 BRCA2 IKBKG PRKACA-1 RAC3 NCOA1 EDN1 FOXO1-1 FOS IL15 NCOA3 RALBP1-1 NCOA4 CCNE1 IL13 TP53 ARHGEF1 PTGS2-2 PTGER4 PTGER1 PTGER2 MDM2-2 PTGER3 XIAP HMOX1 RXRB RXRA RXRG NOS2 ARNT2 MLH1 IL6 GSTA4 F2RL3 CDK2 ETS1 IL6R NFE2L2 IL4R RALA-1 CREBBP CCNE2 LRP5 CSF2RB LRP6 CSF2RA RASGRP1 RASGRP4 PLD2 SPI1 RASGRP3 PMAIP1 GSTA3;GSTA1 ESR2 EPO IL2 IL4 ITGA2B IL7 IL7R CKS1B BDKRB2 BDKRB1 POLK PIM1 ARHGEF11 ARHGEF12 DCC CCNA1 IFNG CAMK2B RUNX1 DAPK1-1 CAMK2D RALB NOTCH1 CAMK2A DLL1 LEF1 DLL3 CXCR4 DLL4 GNA11 HES1 VHL CAMK2G HES5 LAMB4 EPOR IL3 KITLG IL5 CEBPA PPARG SLC2A1 CHUK NFKBIA TRAF3 TRAF6 CDKN1B JAK2 JAK3 PRKCB PRKCA IL6ST HIF1A RELA MAPK9 STAT5B VEGFA BBC3 MYC SMAD2;SMAD3 E2F1 CDKN2B MMP1 BAD MSH6 MSH2 CDK4 IGF1R CCND3 GNAS-1 GNAI3 ADCY3 ADCY2 GNAI1 GNAI2 GNA13 GNG2 GNA12 RALGDS GNAQ GNB1 RET EGFR EP300 HSP90AA1 ARNT ESR1 TPM3 MMP2 RHOA ROCK1 SP1 CDH1 TGFB2 TGFB1 TGFB3 GSK3B TCF7 PDGFA CCND1 AKT3 KLK3;KLK2 PDGFRB AR AKT2 PRKCG TGFA TGFBR1-1 ERBB2 SMAD4 WNT3A HGF WNT5A AXIN1 TGFBR2 APC MET WNT2B FZD10 FRAT2 CCND2 APC2 WNT5B AXIN2 WNT16 CTBP2 CTBP1 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 FZD1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A CDK6 PDGFB TERT FN1 CDKN2A FGF1 PGF CSF1R MAX CUL1 CXCL12 ITGB1 FLT3 FLT4 ITGAV ITGA3 ITGA2 TRAF2 ITGA6 BAK1 NTRK1 RASSF1 RASSF5 FLT3LG IGF2 IGF1 PTK2 MST1 KIT CTNNA1 CTNNA3 CTNNA2 VEGFB VEGFC VEGFD PDGFRA COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 NQO1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260410%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway IL6 IL1B AGT CXCL10 CXCL8 IL10 CSF3 TMPRSS2 ACE2 CCL3L1;CCL3L3;CCL3;CCL18 IL2 IL2RA TNF IL7 CCL13;CCL2 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260410%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MAPKAP1 EGFR AKT3 AKT1 RPL11 RIOK2 RICTOR RIOK1 AKT2 MLST8 FOXO3 MTOR TP53 PIK3CA PTEN MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260410%WP2003%HOMO SAPIENS miR targeted genes in leukocytes ACAA2 TXNRD1 MAPK14 LAMTOR3 CDK6 GNAI2 GNA13 HMOX1 LPL ADAR TPM3 SERPINE2 PLXND1 C1orf56 LMNB2 TUSC2 ARID4B ARF4-1 DCAF7 TXN2 ARHGDIA ANPEP CHORDC1 CDK5RAP1 MAP3K8 CDK5RAP3 FADS1 VPS39 MCL1 G6PD IFRD1 GOLGA7-1 CEBPB PISD MTHFD2 RAB34 PPIF WDFY1 MATR3 PPIB ANAPC1 DDX5 RAB5C TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C BCL2 MRPL20 RDH10 RAB6A KCNN4 SAC3D1 SNX6 MPDU1 ATP6V1F ATP6V0A1 PKM CD164 PHC2 IDH1 TBCA IGF2R TRAM1 HNRNPM BCL6 TNFSF9 SFXN1 SLC25A1 ADPGK SNAP23 TNFAIP2 ATP2A2 SLC7A11 PRSS21 MRC2 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 CSRP1 TMED3 TMEM109 ACP2 SH3BGRL3 NELFCD CTSC SCYL1 CAP1 ANXA2 RHOG PRPF40A GAK SLC7A6 ZEB1 CDCP1 RFT1 FRG1 POM121;POM121C PTRH1 PNP-1 BRPF3-1 UNC93B1 CAPG TYMS CTNNB1 THBS1 PTPA DNAJB1 POLR2C USP1 SHOC2 PDLIM5 CDIPT SRSF10 CA12 SEC24A AP3D1 ARCN1 WDR11 POLE4 ATP6V0E2;ATP6V0E1 FMNL2 EGF EGFR SIGNALING%WIKIPATHWAYS_20260410%WP437%HOMO SAPIENS EGF EGFR signaling CAV1 PTK6 STAM SYNJ1 E2F1 RAB5A PTPRR SH3KBP1 AP2A1 NCK2 NCK1 GAB1 EPS15L1 DNM1 EPN1 PLSCR1 ELK1 RASA1 PXDN ARF6 MAP2K2;MAP2K1 PCNA ASAP1 REPS2 MAPK1 AP2S1 EPS15 HRAS MAPK4 LIMK2 PTPN12 MAP3K2 AP2B1 ITCH NEDD4 MAP3K3 ABI1 JUN SPRY2 MAP3K1 PTPN5 BRAF MAPK14 GRB2 RPS6KA1 MAPK7 KRAS SOS1 RAF1 PDPK1 SOS2 EGF AKT1 CRKL FOXO1-1 RPS6KA5 FOS NCOA3 RALBP1-1 RAC1 RALGDS JAK1 ARHGEF1 PIAS3 GAB2 VAV1 CREB1 CRK RALA-1 PIK3R2 PIK3R1 CBL EGFR RAP1A PLD2 EIF4EBP1 STAT5A STAT1 STAT3 PTPN11 MTOR RPS6KB1 MEF2D RALB CAMK2A MAP3K4 FOSB PAK1 MAPK8 MAP2K5 VAV3 VAV2 ROCK1 FOXO4 PRKCZ CDC42 PLD1 NOS3 SP1 SH3GL2 RPS6KA3 CSK BCAR1 PTK2 MAP4K1 PTEN USP6NL ERBB2 SH3GL3 ERRFI1 PIK3C2B NDUFA13 JAK2 INPPL1 CBLC PEBP1 INPP5D CBLB PRKCB EPS8 ELK4 PRKCD GJA1 PLCE1 PRKCA RPS6KA2 STMN1 CFL1 GRB10 SRC AP2M1 MEF2A PLCG1 USP8 MEF2C MAPK9 PRKCI PTK2B DOK2 RICTOR HGS STAMBP STAT5B RIN1 ABL1 JUND STAM2 STXBP1 IQGAP1 SHC1-1 ATF1 ATXN2 CAV2 IQSEC1 TNK2 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260410%WP5093%HOMO SAPIENS Opioid receptor pathways PIK3CG FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP357%HOMO SAPIENS Fatty acid biosynthesis PECR MECR ACSS2 ECH1 ACSL4 ECHS1 ACSL1 ACACB ACAA2 ACACA ACSL6 ACLY ACSL5 PC ECHDC1 ACSL3 ECHDC2 ECHDC3 HADH DECR1 SCD FASN ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260410%WP5174%HOMO SAPIENS Ulcerative colitis signaling TGFB1 IFNG IL4R NFATC1 IL2RG IL10 NOD2 FOXP3 HLA-DMA MAF TLR2 NFKB1 GATA3 IL4 TNF IL13 IL5 STAT6 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260410%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway CYBA VAV1 TYROBP LYN PIK3C3 LAT C1QC PIK3R2 PIK3R1 ITGB2 NCF1 VAV3 VAV2 HCK PIK3CB PTPN6 PIK3C2A PIK3CG PLCG2 PIK3CD NCKAP1L RAC3 C1QB ITGAM NCF2 ARPC1B NCF4 PIK3R3 TREM2 RAC1 TREM1 PIK3R6 FCGR1A FCER1G PIK3CA SYK SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 CYBB MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260410%WP3877%HOMO SAPIENS MYD88 distinct input output pathway TLR1 TIFA IRAK1 TLR9 UBE2N TLR8 TLR10 TLR7 TLR6 UBE2V1 TLR5 IL1A TRAF6 TLR2 NFKB1 TLR4 MYD88 JUN AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260410%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma BECN1 AGER PINK1 KRAS NFE2L2 MITF PRKN MAP1LC3B2;MAP1LC3B-1 TFE3 TFEB NFKB1 VMP1 IPO8 SHOC2 ATG7 SQSTM1 STAT3 TP53 MDM2-2 HMGB1-1 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF5 LMNA CEBPA LPL FABP4 SREBF1 ZMPSTE24 AKT2 INS;INS-IGF2 LIPE CIDEA FNTA BANF1 ICMT PPARA PRRX1 CIDEC PPARG KLF9 PLIN1 MGLL PNPLA2 GATA2 MAPK9 GATA3 STAT5B LMNB2 LMNB1 PIK3CA KLF2 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260410%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis PBX3 THBS2 COL1A1 COL3A1 COL5A1 YAP1-1 FN1 SNAI2 GPC6 SPARC TEAD1 TEAD2 TEAD3 TEAD4 EDNRA BCAR1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260410%WP430%HOMO SAPIENS Statin inhibition of cholesterol production LDLR ABCA1 APOA4 LPL SQLE SOAT1 APOC2 APOC1 HMGCR FDFT1 CETP MTTP LCAT CYP7A1 LIPC ACSS1 PLTP PDIA2 ABCG8 ABCG5 DGAT1 APOA2 APOA1 APOC3 APOA5 SCARB1 LRP1 APOE APOB TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP75%HOMO SAPIENS Toll like receptor signaling CASP8 CD14 TAB3 MAP3K8 FADD CXCL10 CXCL11 MAP3K7 NFKBIB CXCL9 MAP2K2;MAP2K1 MAPK1 MAP2K7 MAP2K6 MAPK3 MAP2K3 MAP2K4 IL12B IL12A JUN MAPK14 MAPK12 MAPK10 MAPK13 TBK1 IRAK1 CCL5 IKBKE IFNB1-4 CHUK CXCL8 IRAK4 TICAM1 TIRAP IKBKB NFKBIA AKT1 IRF3 IKBKG TRAF3 TRAF6 TLR2 IRF7 NFKB1 TAB2 FOS TAB1 TLR4 RIPK1 MYD88 RAC1 IFNAR2 TOLLIP IL6 TLR1 TLR9 IFNAR1 TLR8 TLR7 TLR6 MAPK11 TLR5 AKT3 STAT1 AKT2 CCL4L2;CCL4L1;CCL4 IL1B IRF5 RELA MAPK9 CCL3L1;CCL3L3;CCL3;CCL18 TNF CD86 CD40 CD80 LBP TICAM2 TLR3 LY96 MAPK8 SPP1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260410%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS6KA6 RPS16 RPS19 RPL18A RPS18 RPL37A-1 RPL35 RPLP2 RPL38 RPL36-1 RPS11 RPS10 RPL39 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS6KA1 RPS8 RPL23 RPS5 RPL22 RPS3A RPSA RPL13A-1 RPL24 RPS6KB2 RPL27 RPL26 RPS6KA3 RPL29 RPL28 UBA52 RPL10;RPL10L-1 MRPL19 RPS15A RPL14 RPS3 RPL13 RPS2 RPL12-1 RPL18 RPS6 RPS27A RPL17 RPL19 RPL35A RPL23A RPL3L RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPS6KB1 RPS6KA2 RPL11 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260410%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus ST6GALNAC3 UGT8 CERS3 B4GALT2 B3GALNT1 B4GALT1 CERK SGMS1 GALNT16 SPHK2 SPHK1 GALNT1 SGMS2 SGPP2 SGPP1 UGCG SGPL1 B3GALT2 B3GALT1 B4GALNT1 KDSR RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260410%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders ETFDH ETFA COQ9 APTX COQ7 COQ6 SLC52A1;SLC52A2 COQ2 FLAD1 RFK PDSS2 PDSS1 COQ8A MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260410%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination ROCK1 WNT4 AXIN1 GSK3B FOXL2 GADD45G MAPK11 CTNNB1 FGFR2 MAPK1 MAP3K4 FGF9 RHOA SOX9 MAP3K1 SRY AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260410%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction ITPR3 ROCK2 ROCK1 RYR1 PPP1R14A GDI1 ADRB2 MYLK PPP1CB CD38 CALM1 IL13 RHOA MYL1 GNAQ PLCB1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260410%WP322%HOMO SAPIENS Osteoblast signaling PDGFB PTH1R COL1A1 PDGFRA PDGFRB PTH ITGB3 TNFRSF11B IBSP TNFSF11 ITGAV SLC17A2 FGF23 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260410%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E VCAM1 GAB3 SELL IL6 PGR MCL1 CD69 CXCL10 CXCL11 CXCL12 IL2RG MAPK11 IL10 CX3CL1 ESR2 STAT5A IL4 IL2RB BCL2 MAPK3 CCL4L2;CCL4L1;CCL4 ITGA4 MAP2K4 IFNG JAK3 CCL5 CXCR4 GATA2 CXCL8 ANGPT2 ANGPT1 CXCR3 CCL3L1;CCL3L3;CCL3;CCL18 IL15 NR3C1 TNF STAT5B IL3 JAK1 VEGFA NCR1-1 CCL8 MRC1 MADCAM1 CCL13;CCL2 PIBF1 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260410%WP4628%HOMO SAPIENS Aerobic glycolysis augmented PKM SLC2A1 TPI1 HK1 PGAM2 GPT ENO1 GAPDH-1 PGK1 ALDOA PFKM GPI LDHA SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260410%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis MESP2 EPHA4 RIPPLY2 TBX6 NOTCH1 DLL1 DLL3 LFNG HES7 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260410%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma MYC CHEK2 FGFR4 CEBPA CTBP1 KDM6A MAP2K2;MAP2K1 JMJD1C TLK1 MYBL1 HRAS CMTR2 MAGI1 KDM6B BRD1 CHEK1 FBXW7 MAGI2 ATRX INSRR ARID5B IL17RD MORF4L1-2 ARID1A FOXP2 MYCN UHRF1 NCOR1 KAT6A MAML3 BCORL1 RAF1 SRCAP DTX4 NSD1 SMARCE1 CNTN6 MGA MYCBP-1 AKT1 ERBIN H2AC16;H2AC11 SMARCA2 FGF16 H1-4 KANSL1 NFIB BCOR TP53 SETD2 CREBBP EP300 MYB PTEN ATM BRCA1 SMC1A ERBB2 NOTCH1 PRKDC ARID4B FOXO3 PIK3CA MAX KMT2C MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260410%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRA2 GABRQ GABRP GABRA1 CREB1 SLC12A5 NGFR GABRA6 GABRA5 BDNF AP2A1 GABRA4 GABRA3 GABRG1 PIK3R2 PIK3R1 STAT3 AP2B1 PTEN RHOA PIK3CB PIK3CG ROCK1 JAK2 NTRK2 PLCG1 GABRB3 PIK3R3 GABRB2 GABRB1 CREM SHC1-1 AP2A2 PIK3CA GABRG3;GABRG2 GABRE GABRD NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260410%WP438%HOMO SAPIENS Non homologous end joining LIG4 POLL NHEJ1 PRKDC WRN XRCC6 DCLRE1C XRCC4 POLM XRCC5 RANKL RANK SIGNALING%WIKIPATHWAYS_20260410%WP2018%HOMO SAPIENS RANKL RANK signaling TRAF1 LYN TRAF5 MAP3K7 MAP2K2;MAP2K1 MAPK1 MAP2K7 MAP2K6 MAPK3 JUN TRAF2 MAPK14 CDC42 CHUK NFATC1 IKBKB NFKBIA AKT1 IKBKG TRAF3 TRAF6 NFKB1 TAB2 FOS TAB1 RAC1 SYK GAB2 PTK2 PIK3R2 PIK3R1 CBL SPI1 FHL2 TNFRSF11A PAPSS2 SQSTM1 RELB STAT1 AKT2 MTOR MITF SRC PLCG1 RELA MAPK9 TNFRSF11B TNFSF11 NFKB2 MAPK8 DOPAMINE METABOLISM%WIKIPATHWAYS_20260410%WP2436%HOMO SAPIENS Dopamine metabolism PRKACA-1 DDC MAOB TH MAOA TYR COMT PRKACB-1 SOD1 NQO1 PPP2CB;PPP2CA 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation DAPK2 SSC4D MDH2 ZP3;POMZP3 STYXL1 POR PTPMT1 G3BP1 LMNA KIF1C SFN ZP1 RAF1 ZP2 YWHAG HSPB1 SRRM3 TMEM120B RHBDD2 TMEM120A BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260410%WP5234%HOMO SAPIENS Bardet Biedl syndrome DYNC2H1 IQCB1 MKKS IFT140 IFT80 CFAP410 WDR35 LZTFL1 BBS10 IFT43 EVC BBS12 RP2 IFT81 MAK PTCH1 TMEM216 GPR161 KIF7 EFHC1 WDPCP GLI3 EFHC2 CILK1 ARNTL GLI2 CNGB1 CEP104 ARL6 SMO ARL3 DYNLT2B CRX PKD1L1 DYNC2LI1 PKHD1 IFT74 ARL13B TMEM67 TTC21B RAB23 PDE6D NPHP3 BBS2 NEK8 EVC2 BBS1 USP9X WDR19 PCARE SCLT1 LCA5 IFT122 DCDC2 FUZ BBIP1 C8orf37 TTC8 MKS1 IFT27 CEP41 TRIM32 CLUAP1 INPP5E DYNC2I2 INVS DYNC2I1 TRAF3IP1 IFT172 CEP164 PKD2 PKD1 IFT52 FLCN ZIC2 TMEM107 OCRL CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 CEP290 SCAPER BBS4 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP8 PERP CHEK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP3 BAX APAF1 PMAIP1 DDB2 BID SERPINE1 SIAH1 TP53 SHISA5 CASP9 CYS1 MDM2-2 PTEN EI24-1 ATM SESN3 BBC3 ZMAT3 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260410%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 NOS2 PRMT5 PRMT8 PRMT7 PRMT2 PRMT3 DDAH1 NOS3 DDAH2 CARM1 NOS1 PRMT1 VISUAL CYCLE%WIKIPATHWAYS_20260410%WP5534%HOMO SAPIENS Visual cycle RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RDH12 RDH11 RBP3 RBP1 RHO RDH5 LRAT RDH10 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260410%WP4255%HOMO SAPIENS Non small cell lung cancer CASP8 CASP3 E2F1 BAD ARAF E2F2 CDK4 E2F3 NRAS MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 CDKN1A BRAF GRB2 KRAS SOS1 BAK1 PDPK1 RAF1 GADD45B SOS2 EGF GADD45A GADD45G BAX PIK3CD AKT1 CDK6 RASSF1 RASSF5 BID TP53 RXRB RXRA RXRG EML4 RET CCND1 EGFR AKT3 STAT5A AKT2 DDB2 STAT3 KIF5C PRKCG RARB KIF5B KIF5A POLK CRABP2 CRABP1 TGFA STK4 PIK3CB FHIT CDKN2A ERBB2 JAK3 HGF PRKCB PLCG2 PRKCA MET PLCG1 RB1 STAT5B FOXO3 CASP9 ALK PIK3CA CYCS-1 GASTRIN SIGNALING%WIKIPATHWAYS_20260410%WP4659%HOMO SAPIENS Gastrin signaling MYC BIRC5 BAD BIRC2 BIRC3 ELK1 MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 CDKN1A JUN MAPK14 BMP2 GRB2 KRAS SOS1 RAF1 LAMTOR3 ATF2 CXCL8 IRS1 IKBKB AKT1 PRKACA-1 FOXO1-1 FOS RAC1 PTGS2-2 RPS6 KLF4 GNAQ CREB1 CRK PIK3R2 PIK3R1 EGFR EIF4EBP1 FYN IL2 STAT3 PTPN11 MTOR RPS6KB1 MEF2D CDKN2A PIK3R3 FOXO3 PAK1 MAPK8 CASP3 MAP3K11 ITGB1 MMP7 PPARG RHOA ROCK1 CDC42 CHUK NFKBIA SP1 CDH1 BCL2L1 NFKB1 SERPINE1 BCAR1 ANXA2 JAG1 PTK2 GSK3B CCND1 CTNNB1 ARRB1 KIT ARRB2 CD44 PRKCQ CLDN1 KAT5 MEF2B;BORCS8-MEF2B SLC9A3 CDKN1B PRKD2 JAK2 PRKD1 ARHGEF28 PRKCH SLC9A1 YES1 PRKCE TCF4 PRKCD ELAVL1 PRKCA GAST SERPINB2 RHOD RHOB CCKBR SRC PXN HDC PLCG1 HDAC7 RELA CHGA MEF2C MAPK9 TJP1 EGR1 VEGFA SHC1-1 PIK3CA CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260410%WP2029%HOMO SAPIENS Cell differentiation index HDAC5 TLX3 TLX2 LEFTY2;LEFTY1 TLX1 STAT3 SRF TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260410%WP5130%HOMO SAPIENS Th17 cell differentiation pathway CD3E CD3D IL27RA SMAD2;SMAD3 PPP3CA CRY1 CLOCK NFIL3 TBX21 IL21R NR1D1 PER1 CD4 IL17F CD247 IL17A ARNTL MAPK1 IL2RA JUN IL23A MAPK14 NFATC1 IKBKB FOXP3 NFKBIA HLA-DMA NFKB1 RORA FOS GATA3 JAK1 TYK2 TGFB1 IRF4 RXRA ZAP70 RARA LAT LCK IL6 IL6R IL4R AHR SOCS3 IFNGR1 STAT5A IL2 HSP90AA1 STAT1 IL4 STAT3 MTOR PRKCQ STAT6 TGFBR1-1 IFNG RUNX1 JAK2 IL1B HIF1A PLCG1 IL21 IL22 IL23R RORC CD3G IL27 MAPK8 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD3B1;HSD3B2 UGT1A1;UGT1A6 HSD17B2 HSD17B3 CYP11A1 SRD5A2 CYP17A1 SRD5A1 CYP19A1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260410%WP15%HOMO SAPIENS Selenium micronutrient network MPO TXNRD3 SERPINA3 TXNRD2 PLAT TXNRD1 MTR-1 SAA2;SAA1 CBS;CBSL KYNU GGT1 INS;INS-IGF2 SEPHS2 FGB FGA SAA2-SAA4;SAA4 GPX1 GPX4 GPX6 DIO1 FGG DIO3 KMO SELENOO F7 SELENON SELENOS SELENOP SELENOT PLG TXN INSR SELENOK HBD;HBB SELENOI SOD1 ICAM1 PRDX3 PRDX2 CRP PRDX5 PTGS1 PRDX4 PRDX1 ALOX5 NFKB1 PNPO XDH GSR MTHFR SCARB1 ALOX15B SERPINE1 CAT SOD3 HBA2;HBA1 PTGS2-2 CTH ALB ALOX5AP CCL13;CCL2 APOB LDLR ABCA1 SOD2 IL6 F2 IFNG IL1B FLAD1 RFK RELA APOA1 TNF NFKB2 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260410%WP5506%HOMO SAPIENS Disorders of NAD metabolism NAXD NADSYN1 CD38 BST1 NAXE SILDENAFIL TREATMENT%WIKIPATHWAYS_20260410%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 NOS2 GUCY1A1 GUCY1B1 PDE4C TFAM-1 PDE4B ZNF746 NOS3 PDE4A GSK3B GAPDH-1 PDE5A NOS1 PRKG1 PRKN AKT3 AKT1 PPARGC1A AKT2 PDE4D-1 NRF1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260410%WP2253%HOMO SAPIENS Pilocytic astrocytoma NRAS NF1 BRAF GRB2 KRAS HRAS SOS1 PTPN11 RAF1 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260410%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport ABCB1 ABCD3 ABCB4 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SCP2 ABCC3 ABCC4 HSD3B7 ABCC2 SLC10A1 SLC27A2 ATP8B1 SLC10A2 SLC51A BAAT SLC51B CYP7B1 CYP8B1 CYP27A1 AMACR ACOX2 FABP6 SLC27A5 CYP7A1 HSD17B4 AKR1D1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260410%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins RPL30 POU2F1 NFE2L2 FABP1 TXNRD3 TXNRD2 TXNRD1 SEPHS2 GPX1 GPX4 JUN GPX6 DIO1 DIO3 SELENBP1 SELENOO SEPHS1 PSTK SELENON EEFSEC SELENOS SECISBP2 SELENOP TRNAU1AP SELENOT SEPSECS SARS1 SELENOK SARS2 SP3 SELENOI SCLY SP1 RELA NFKB1 FOS CREM CTH UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260410%WP5158%HOMO SAPIENS Urotensin II mediated signaling VCAM1 SMAD2;SMAD3 CASP3 CDK1 PCNA MAPK1 NCF1 BCL2 MAPK3 MMP2 MMP9 RHOA MAPK14 CHUK BAX ICAM1 IKBKB AKT1 IRF3 PRKACA-1 ALOX5 NFKB1 NCF2 NCF4 CCNE1 DDIT3 CYBB CYBA HMOX1 TGFB1 ABCA1 AGTR1 IL6 FN1 CDK2 GSK3B CREBBP EGFR CTNNB1 EP300 STAT3 PTPN11 PTEN JAK2 IL1B COL1A1 COL3A1 CAMK2A GSK3A NPPB AIFM2 NPPA UTS2R RELA TRPC4 MAPK9 COL2A1 HDAC5 ESPL1 FSCN1 TNF HSPA2 NOX4 ACTA2 CASP9 MAPK8 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2B6 CYP2C9;CYP2C19 CYP2C18-1 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260410%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR POLB HERC2 CHEK2 TRIM28 EXO1 E2F1 UIMC1 BARD1 UPF1 SMARCC2 RMI1 TOP3A RECQL PLK1 CDC25C FANCD2 EEF1E1 PARP1 MSH2 MCPH1 MCM2 ABRAXAS1 XPA CDK1 RNF8 PCNA BRCC3 PPM1D PML BRIP1 RAD51 RECQL5 FOXM1 CDC45 RBBP8 CLSPN TP53BP1 FANCI CHEK1 POLN FANCA RPA1 HUS1 RFWD3-2 RPA2 PALB2 CLK2 RAD1 TOPBP1 SEM1 RAD52 ATRIP TDP1 RAD17 ATR RAD9A BCL6 SP1 BRCA2 IKBKG TP53 MDM2-2 MLH1 CDK2 WRN XRCC5 USP1 MDC1 RAD50 MRE11 ATM NBN BRCA1 SMC1A CEP164 PRKDC DCLRE1A SMARCAL1 FEN1 UBE2D3-1 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 CPS1 GLS2 ARG1 ASL NAGS ASS1 OTC SLC25A13 FOCAL ADHESION%WIKIPATHWAYS_20260410%WP306%HOMO SAPIENS Focal adhesion CAV1 PTK6 BAD LAMC3 LAMC2 LAMC1 ELK1 MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 JUN BRAF LAMA5 LAMA2 LAMA1 LAMA4 MAPK10 LAMA3 IGF1R GRB2 CCND3 SOS1 RAF1 PDPK1 LAMB3 EGF LAMB2 LAMB1 PIK3CD CRKL MYL12B RAP1B RAC1 VAV1 RAPGEF1 CRK PIK3R2 PIK3R1 EGFR RAP1A FYN THBS2 COL1A1 COL2A1 SHC4 SHC2 ACTN4 SHC3 PIK3R3 ACTG1 PAK1 SPP1 MAPK8 MYL2 PAK2 ACTB-1 BCL2 VAV3 VAV2 FGR RHOA HCK ROCK2 ROCK1 CDC42 TESK2 ACTN1 DIAPH1 MYL5 MYL7 TLN2 TLN1 TXK MYL12A MYL10 VASP SRMS PARVA PARVB MYLPF COL1A2 PARVG ARHGAP5 BCAR1 EMP2 RELN FLNA FLNB FLNC PPP1CA ZYX MYLK2 TNC ARHGAP35 MYLK3 MYLK4 COMP GSK3B PPP1CC PDGFA TNN CCND1 CAPN2 TNR AKT3 CTNNB1 VCL BLK PDGFRB VTN CHAD CAV3 TNK1 ITGA10 COL5A3 AKT2 ITGA11 COL5A2 PRKCG ITGB5 RASGRF1 ILK ITGB8 PTEN ITGB7 ITGB6 PIK3CB PPP1R12A VWF COL6A2 ERBB2 ITGA8 ITGA7 ITGA5 HGF PPP1R12B PPP1R12C DOCK1 ITGA9 THBS4 THBS3 STYK1 MET PIP5K1C MYLK PPP1CB CCND2 IBSP PIK3CA BIRC2 BIRC3 AKT1 RAC3 XIAP PDGFB PDGFD PDGFC FN1 ITGB3 ITGA2B TNXB PGF ITGB1 FLT1 ITGB4 ITGAV ITGA4 ITGA3 ITGA2 ITGA1 ITGA6 KDR IGF1 PTK2 THBS1 PAK3 PAK4 VEGFB VEGFC VEGFD BUB1B-PAK6;PAK6 PRKCB PDGFRA COL4A2 PRKCA COL4A1 COL4A4 COL4A6 SRC PXN MAPK9 VEGFA SHC1-1 CAV2 TNK2 NRF2 ARE REGULATION%WIKIPATHWAYS_20260410%WP4357%HOMO SAPIENS NRF2 ARE regulation HMOX1 CEBPB YES1 NFE2L2 GSK3B INSR PRKCA AIMP2 KEAP1 PGAM5 RBX1 GCLM SRC SLC7A11 GSTA3;GSTA5;GSTA1;GSTA2 EPHB2 MAF FYN CUL3 GCLC PIK3CA NQO1 MAPK8 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma MYC SMAD2;SMAD3 CASP3 BIRC5 MMP1 BIRC3 E2F2 MAPK3 CDKN1A VAV2 JUN MAPK14 GRB2 SOS1 CXCL8 AKT1 BCL2L1 NFKB1 RAC1 JAK1 TP53 PTGS2-2 TGFB1 NOS2 IL6 IL6R CCND1 CD44 STAT3 PTPN11 TGFBR1-1 BRCA1 SMAD4 LEF1 COL4A2 UCHL1 MYOF HIF1A HNF1A CTTN RRM2-1 PODXL CXCR1 FASLG FRZB VEGFA CASP9 CASP7 MAPK8 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260410%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYC ERBB4 WNT16 ACTR3-1 CAMK1 NCK1 ELK1 ACTA1 MAP2K2;MAP2K1 MAPK1 WNT11 DVL1 CDKN1A MAP2K4 GPX1 RHOA FZD1 JUN PPP2CB;PPP2CA ROCK2 FZD3 FZD2 FZD5 GRB2 SOS1 RAF1 FZD7 FZD6 FZD9 FZD8 SOD1 AKT1 FN1 PTK2 GSK3B FZD4 NOS1 CBL EGFR CTNNB1 STAT5A TGFA PIK3CG ERBB2 CDKN1B AXIN1 APC SRC FZD10 PLCG1 MYLK NEFL NEFM NEFH ACTR2 DAAM1 SHC1-1 PFN1 PFN2-1 MYL1 PFN3 PAK1 GRIA1 MAPK8 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy CAV1 DGAT2 CAVIN1 AGPAT2 BSCL2 GRB2 GPAT3 IRS1 HIF1A ITGB4 FYN DGAT1 AKT2 LPIN1 INS;INS-IGF2 LPIN2 LPIN3 PIK3CA AXON GUIDANCE%WIKIPATHWAYS_20260410%WP5289%HOMO SAPIENS Axon guidance ROBO2 NRP1 NCK1 CXCL12 SEMA5B ROBO3 BMPR2 ROBO1 DPYSL5 PTCH1 DPYSL2 RASA1 ITGB1 BOC EPHB1 SEMA6C RRAS TRPC1 UNC5D MAPK1 RGMA SHH ENAH HRAS NGEF SEMA7A SEMA3A NTN4 NTN3 EFNB1 PARD6A ABLIM3 SLIT1 PLXNA1 SLIT3 SLIT2 ROCK1 LRIG2 FZD3 LRRC4C SRGAP2 PRKCZ NTNG2 CDC42 L1CAM GDF7 PDPK1 RAF1 CDK5 FES BMPR1B GNAI1 MYL12B RAC1 EPHA2 WNT4 GSK3B FYN ILK ARHGEF12 DCC WNT5A CXCR4 PRKCA RHOD MET CFL1 SRC PARD3 ABL1 RYK-1 EFNA1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260410%WP391%HOMO SAPIENS Mitochondrial gene expression PPP3CA CREB1 TFAM-1 ESRRA GABPA MYEF2 MTERF3 TFB2M SP1 MTERF1-1 GABPB1 PPARGC1A TFB1M POLRMT PPARGC1B PPRC1 CAMK4 HCFC1 NRF1 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260410%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy PKLR G6PD ARAF MAP2K2;MAP2K1 PPARGC1A PDHA1 MAPK1 MAPK3 MTOR GPX4 LDHA BRAF PKM SLC16A1 SLC2A1 RPS6KA1 RAF1 RPS6KA2 MITF ACSS1 DLD RPS6KA3 RPTOR PFKFB2 GSR SLC1A5 MLST8 GLS LDHB NAMPT DLAT PGLS SLC16A3 TRAP1 CPT1A FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260410%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma KDM2B H2AZ2;H2AZ1 MACROH2A1 DUSP6 H2AJ RNF2 PCGF1 BCL6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AB2;H2AB3;H2AB1 H3-3A MACROH2A2 EED MAPK1 EZH2 BCOR MAPK3 SUZ12 CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260410%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer CDK2 PIK3R4 PIK3R2 PIK3R1 EGFR CCND1 CDK4 AKT3 NRAS MAPK1 AKT2 HRAS INS;INS-IGF2 MAPK3 ESR1 MTOR CYP19A1 CDKN1A PIK3C2G PIK3CB PIK3C2A PIK3CG ERBB2 CDKN1B PIK3C2B IGF1R KRAS RAF1 IRS1 PIK3CD AKT1 CDK6 RPTOR PIK3R3 CCNE1 PIK3R6 PIK3R5 PIK3CA STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis HSD3B1;HSD3B2 CYP11A1 SRD5A2 CYP17A1 CYP21A2 SRD5A1 AKR1D1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260410%WP136%HOMO SAPIENS Phase I biotransformations non P450 CES2 CES1 PON3 PON2 LIPA PON1 ESD CES5A TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260410%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR9 IRF9 IFNAR1 TLR7 TLR6 EIF2AK2 TREML4 OAS3 STAT1 STAT2 DDX58 TBK1 IFIH1 IKBKE MAVS OAS1 IRAK4 IRF3 TMPRSS2 TRAF3 ACE2 TRAF6 TLR2 IRF7 TLR4 MYD88 JAK1 IFNAR2 TLR3 TYK2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260410%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK1 STAT3 MAPK3 JAK1 EGFR HEROIN METABOLISM%WIKIPATHWAYS_20260410%WP2645%HOMO SAPIENS Heroin metabolism CES2 CES1 BCHE CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260410%WP4562%HOMO SAPIENS Canonical NF kB pathway IKBKG RELA NFKB1 NFKBIE CHUK REL NFKBIA IKBKB ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260410%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy TST ETHE1 SUOX SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260410%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides A3GALT2 CERS1 CERS2 UGT8 CERS3 B4GALT1 CERK SGMS1 DGAT1 SPTLC1 SPHK1 SGMS2 CERS4 UGCG ASAH1 DES CERS5 CERS6 B3GNT5 B4GALNT1 KDSR A4GALT BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation DKK1 DCN SST WNT4 SFRP1 BMP2 CTNNB1 FOXO1-1 SMAD1 BCL2L11 LEFTY2;LEFTY1 SMAD9 SMAD5 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders MTR-1 BHMT CBS;CBSL AHCY ADK CDO1 MAT1A CSAD MAT2B GNMT CTH PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260410%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA SCP2 HSD17B4 ACOX1 ACAA1-1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2-2 EPHX2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PISD PCYT1B PCYT1A CHKB PCYT2 CHKA PTDSS2 PTDSS1 ETNK2 ETNK1 CEPT1 PEMT CHPT1 SGPL1 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260410%WP5526%HOMO SAPIENS Age related macular degeneration PRKAA2 PRKAG1 PRKAG2 PRKAG3 PPARGC1A PRKAA1 PMAIP1 RPTOR SIRT1 MLST8 PRKAB2 MDH1 MAPK3 PARP2 MTOR PRKAB1 RPS6KB1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway ARL5B CUL1 RGS2 DNER ENC1 ANKRD1 TNS4 SRGN IL11 FGFBP1 EDN2 BIRC2 TSC22D3 BIRC3 SERPINB9 NAV3 ADGRF4 CDC42EP3 SCNN1A PMP2 ANGPTL4 PTGES3-1 SLC26A2 ABHD2 NR1I3 AMIGO2 NR1I2 POU5F1;POU5F1B PRRG4 FGD4 SEC14L1 GPR153 SERTAD2 STOM JUN LRRC8A MGAM PPP1R14C CAVIN2 PLK2 DNAJC15 KTN1 BHLHE40 S100P SPRY1 CPEB4 GADD45B ACKR3-2 NR3C1 CCL20 PTGS2-2 ALOX5AP CCL13;CCL2 RXRA PDE4B HSP90AA1 SLC19A2 B3GNT5 SNAI2 TGFBR3 MFGE8 ZIC2 ETNK2 CDKN1C NFKB2 TNFAIP3 AKAP13 THBD EPB41L4B SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260410%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling BRAF CREB1 ELK4 HTR4 GNAS-1 HTR6 HTR7 RAP1A ELK1 MAP2K2;MAP2K1 MAPK1 RPS6KA5 EGR1 MAPKAPK2 NR3C1 SRF MAPK3 ATF1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260410%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome CLOCK SMARCC2 ELK1 PCNA SIRT6 ARNTL SMAD1 BCL2 SMAD9 SMAD5 ITCH BMP2 ATF2 BMPR1B SMARCB1 RIF1 CDH1 FRMPD2 OGDHL EIF4ENIF1 ELOA FAM170B VSTM4 SIRT1 NEO1 SLC18A3 MEN1 C10orf71 NOG BAZ1B ERCC5;BIVM-ERCC5 RGMB WDFY4 PARG CUL5 LRRC18 CHAT DDX21 ARHGAP22 HSF1 HSF4 SF3B1 DRGX KDM4D C10orf53 SMARCA5 DEK GDF5 TMEM273 MYO1C MYBBP1A UVSSA ERCC8 ERCC6 BMPR1A DLST DLD JUND NLRP3 MAPK8 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260410%WP5300%HOMO SAPIENS TROP2 regulatory signaling IGF2 VIM FN1 IGF1 CDK2 PTK2 PIK3R1 EGFR CCND1 CDK4 CTNNB1 ITGB1 STAT1 ACVRL1 BCL2 PSEN2 MDK TACSTD2 ABCC1 CHEK1 CLDN7 PECAM1 PTEN PAK4 JUN CDKN2A CLDN1 MMP13 CDKN1B JAK2 ITGA5 IGF1R IGF2R NOTCH1 PRKCD PRKCA BAX SRC CDH1 RB1 TLN1 NFKB1 RACK1 RAC1 CCNE1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260410%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3C2A PIK3CG PIK3C2B PIK3R4 PIK3R2 PIK3R1 PIK3CD PIK3R3 PIK3R6 PIK3R5 PIK3CA PIK3C2G PIK3CB GDNF SIGNALING%WIKIPATHWAYS_20260410%WP5143%HOMO SAPIENS GDNF signaling FMOD IRINOTECAN PATHWAY%WIKIPATHWAYS_20260410%WP229%HOMO SAPIENS Irinotecan pathway SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UGT1A1;UGT1A6 CES2 CES1 BCHE ABCC2 ABCC1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG2 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MXRA8 VWA1 AURKAIP1 SMAD2;SMAD3 PERM1 TRAF5 KLHL17 MEPCE LRP4 UBE2J2 PARD6B ATAD3A;ATAD3B PHKG2 BTLA TNFRSF14 PUSL1 MCM2 TAS1R3 NADK HES4 ARF6 TNFSF18 HSPA8 CFAP74 CD160 MIB2 B3GALT6 CALML6 PEX10 MRPL20 DVL1 ISG15 PEX12 RNF223 SKI MORN1 KRT17 TNFSF4 TRAF2 FNDC10 ANKRD65 INTS4 PLCH2 INTS9 AGRN SLC35E2B PRKCZ C1orf159 CUL3 GABRD TGFB1 GNB1 VTN ESR1 INTS11 PANK4 INTS13 INTS14 INTS10 SMAD4 CDK11A;CDK11B DLST GDE1 TMEM52 GRIK2 IFIH1 DLL1 IFIT1 NOC2L ELAVL1 OR4F21;OR4F16;OR4F29;OR4F3 METTL14 SDF4 TRIM25 PLEKHN1 RBX1 HES5 CCNL2 TNFRSF4 SAMD11 MUSK TNFRSF18 OR4F5;OR4F17;OR4F4 SSU72 PEX2 COMMD1 DKK3 ACAP3 RER1 VEGFA SCNN1D CPTP MMP23B C1QTNF12 PEX5 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260410%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol IL17F IL17A EBP SCP2 HSD3B7 ESR2 DHCR7 SLC27A2 NR1I2 ESR1 BAAT CYP7B1 CYP8B1 CYP27A1 AMACR ACOX2 SLC27A5 IL25 INSIG1 CYP46A1 DBP THEM5 CYP7A1 ACOT2;ACOT1 ACOT9 EPHX2 ACOT8 ACOT7 NR1H2 ACOT11 ACOT12 ACOT13 CYP39A1 SULT2B1 HSD11B1 CH25H HSD11B2 GPR183 SULT2A1-4 IL17D ACOT6 LBP IL17C AKR1D1 IL17B RORC CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ACOT4 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260410%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACE ACAD9 IL18 BCS1L TERF2 IL6 NDUFAF2 TERF2IP REN NDUFAF1 NOX1 SIRT6 AGT RPS6KA1 PHB MAVS STING1 TRAF3 ACE2 TRAF6 NFKB1 TNF NLRP3 ECSIT NLRX1 TOMM70 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260410%WP5598%HOMO SAPIENS Sodium channel in epilepsy FGF14 FGF13 FGF12 PTPRN GSK3B NEDD4L PSEN1 SCNM1;TNFAIP8L2-SCNM1 SCN11A PDCD10 SCN9A SCN7A SCN5A FYN SCN3B SCN3A SCN1B SCN1A PRRT2 MAPK8IP2 BACE1 WEE1 SCN10A NFASC NEDD4 SCN8A SCN4A SCN2A SCN4B SCN2B RNF121 JAK2 CAMK2A AKT1 CALM1 RACK1 TNF NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260410%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAV1 PLCB2 PLCD1 NRAS MAPK1 HRAS ISG15 MAPK3 JUN MAPK14 MAPK12 PLCB3 MAPK13 PRKCZ MAPK7 KRAS CXCL8 NOD2 IKBKB SP1 TLR2 NFKB1 TNFRSF1A TLR4 JAK1 IFNAR2 TYK2 CCL13;CCL2 RXRB RXRA RXRG IL6 ETS1 TLR8 MAPK11 IFNGR1 IFNGR2 RELB STAT1 STAT2 PRKCG PRKCQ IFNG IFI27L2 CAMK2B IFI44L CAMP CAMK2D MED1 RSAD2 CAMK2A PRKCH CYP27B1 PRKCB VDR PRKCE PLCG2 CD40LG PRKCD CYP24A1 PLCE1 PRKCA DEFB4A;DEFB4B SP3 CAMK2G MAPK9 TNF CD40 PLCB4 NFKB2 PLCB1 MAPK8 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260410%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F9 AIFM2 F10 GGCX PROS1 F7 F2 VKORC1 VKORC1L1 UBIAD1 NQO1 PROC MELANOMA%WIKIPATHWAYS_20260410%WP4685%HOMO SAPIENS Melanoma ERBB4 E2F1 BAD ARAF E2F2 CDK4 E2F3 NRAS MAP2K2;MAP2K1 MAPK1 CALML6 HRAS CALML3 MAPK3 CALML4 CDKN1A RHOA BRAF GRB2 KRAS SOS1 BAK1 RAF1 GADD45B SOS2 GADD45A GADD45G BAX PIK3CD AKT1 CDH1 CDK6 KDR RAC1 TP53 MDM2-2 PDE5A PIK3R2 PIK3R1 CCND1 AKT3 VCL KIT AKT2 DDB2 PTPN11 POLK PTEN PIK3CB CDKN2A NF1 MITF RHOB RB1 CTTN STK19 GRM3 CALM1 PREX2 SHC2 EXOC7 RHOC PIK3R3 GRIN2A CALM3;CALM1 CALM2 PIK3CA PAK1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CASP8 TP63 DDIT4 NUMB IRF6 E2F1 CSMD3 FKBP1A FADD FAT1 LTBR FGFR1 BIRC2 CDK4 NRAS PRKAA1 HRAS CDKN1A PRKAA2 IGF1R KRAS PDPK1 FGFR3 KEAP1 RPS6KB2 AKT1 TRAF3 CDK6 TSC1 NFKB1 RPTOR MLST8 TP53 CUL3 RPS6 TERT RHEB MAPKAP1 NFE2L2 PIK3R2 PIK3R1 CCND1 EGFR AKT3 CTNNB1 EIF4EBP1 EIF4E AKT2 MTOR PTEN REL PIK3CB CDKN2A PIK3CG ERBB2 SMAD4 NOTCH1 TGFBR2 TSC2 NOTCH2 RB1 RELA RICTOR AJUBA VEGFA PIK3R5 NFKB2 MAML1 PIK3CA STK11 SESN1 SESN2 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260410%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways ALDH4A1 OAT PYCR1 PEPD PRODH;LOC102724788 P38 MAPK SIGNALING%WIKIPATHWAYS_20260410%WP400%HOMO SAPIENS p38 MAPK signaling MYC CREB1 MAP3K7 DAXX TRADD MAPKAPK5 ELK1 STAT1 MAPKAPK2 HRAS MAP2K6 SMIM40 RASGRF1 MAP2K4 PLA2G4A MEF2D TGFBR1-1 MAP3K1 TRAF2 MAPK14 GRB2 CDC42 MKNK1 ATF2 MAP3K9 MAP3K5 HSPB1 RPS6KA5 HMGN1 RIPK1 RAC1 SHC1-1 DDIT3 MAX TGFB2 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260410%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling SMAD2;SMAD3 PLCB2 TRAF5 MAPK1 MAPK3 IL12B IL12A PLCB3 ADCY3 IRS1 AKT1 PRKACA-1 FOS CAMK4 GLS JAK1 IL13 DLAT CREB1 IL6 IL6R IL4R SOCS3 IL4 STAT1 STAT3 FGF2 IFNG CAMK2B IL1B CAMK2D CAMK2A CAMK2G DLD TNF GRIN2A BDNF SLC7A10 GOT1-1 CNTF GLUL PSPH IL1A SLC38A1 IL1R2 SLC1A4 ARC NSMF GRIA2 BCL2 SHMT2 SHMT1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC38A3 SLC38A2 LRRC8A SLC38A5 NGF GRIA3 GRIA4 SLC2A1 TRPM4 LIF GRIN2C GRIN2B GLS2 GRIN2D ADCY1 GFAP SMAD7 ADCY8 INSR GRIN3B DAO GRIN3A SLC6A9 GRIK5 GRIK3 GRIK4 GRIK1 GRM1 NFKB1 GRM2 GRM5 TNFRSF1A GRM4 GRM7 GRM8 PHGDH TNFRSF1B LTA CAMKK1 CAMKK2 SRR LRRC8C TGFB2 LRRC8D TGFB1 SLC17A6 TGFB3 SLC17A7 IL1R1 LRRC8B DISC1 PPP1CA LRRC8E IL10RB IL10RA IGF1 GRIN1 PSAT1 PPP1CC NOS1 IL10 IFNGR1 PDHA1 IFNGR2 PRKCG STAT6 TGFBR1-1 SMAD4 GRIK2 PRKCB TGFBR2 TGFBR3 IL13RA1 PRKCA CFL1 IL6ST PPP1CB CALM1 NFKB2 PLCB4 GRIA1 PLCB1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260410%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma PDGFB TGFB1 TGFB3 BIRC7 SETD2 CREBBP PRCC ELOB CTSK SFPQ-1 CADM2 TFE3 COL21A1 EP300 TFEB ARNT DVL2 CDKN1A TGFA FH EPAS1 SLC2A1 EGLN1 EGLN3 EGLN2 VHL RBX1 DIAPH1 HIF1A CUL2 VEGFA ELOC-1 TGFB2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260410%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNB1 PPP1CA CDK5 ADCY2 GNAI1 PRKACA-1 CHRNB2 CHRNA3 CHRNA5 KCNK9 CHRNA4 GNG2 DDC CHRNA6 PPP1R1B TH DRD2 DRD3 KCNK3 SLC18A2 DRD4 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260410%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione DPEP1 OPLAH GGT1 GCLC GGCT GSS PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260410%WP2878%HOMO SAPIENS PPAR alpha pathway MYC RXRA KLK15 CPT2 ACADM EHHADH-1 FABP1 ACAA1-1 CYP7A1 CCND1 CDK4 PLTP CDK1 SCP2 NR1H3 APOA2 APOA1 APOC3 APOA5 SLC27A1 PPARA CYP8B1 CPT1A STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260410%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 CGAS IL1B GSDMD ITPR1 TBK1 F3 IKBKE IFNB1-4 STING1 CHUK NFKBIA IKBKB IRF3 IKBKG RELA NFKB1 NFKBIE NLRP3 NLRX1 REL LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260410%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G1B PLA2G4E PLA2G3 PLA2G5 PLA2G6 PLA2G7 ALOX5 SLCO2A1 PLA2G10;LOC100652777 HRAS TP53 PTGS2-2 CDKN1A PLA2G4A MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response MYC RAD52 CDKN1B CREB1 E2F1 CCND3 CDC25A CCND1 CDK6 CCNE1 ABL1 TP53 CDKN1A ATM SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260410%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways RUNX3 ADCYAP1 PRKAR1B PRKAR1A KCNQ1 LMX1B TPH2 DLX2 TPH1 ADCYAP1R1 MAZ GAPDH-1 NEUROD1 YWHAB DEAF1 ALDOA HDAC1 PRKAR2B PRKAR2A TPPP TAC1 SPTBN1 NKX2-2 MAP2 HTR1A POU2F2 G6PC1 PHOX2B PHOX2A TF NANOG;NANOGP8 FEV PAH NFYA-1 CC2D1A JUN TP73 YWHAE SNAP25 RYR2 HADHB-1 CDCA7L ECE1 CTCF YBX1 HTR2A SLC6A4 MECP2 SNTA1 YWHAH CXCL8 EN1 HTR3A TACR1 SSTR1 SSTR2 PRKACA-1 YWHAZ HADHA NOS1AP AVP RORA SLC25A4 GATA3 VAMP2 NR3C1 ATP1A3 CHRNA7;CHRFAM7A IL13 ASCL1 HDAC9 CREM HSPD1 KCNJ8 MBD1 FMO3 CPT1A REST PLP1 CREB1 GABRA1 IL6 IL6R RET CREBBP SCN5A EP300 SCN3B THRB ESR2 DDC TH MAOA MYB KCNH2 SCN4B IL1B SST GATA2 YWHAG HES1 SP3 HES5 TNF CASP3 GCK BDNF CEBPB GNB3 PPARGC1A IL1A PPARGC1B FOXM1 POU5F1;POU5F1B SLC1A3 NGF BHLHE40 NTRK2 PRKACB-1 SP1 NFKB1 YWHAQ IL1RN CHAT GRIN1 PBX1 IL10 CTNNB1 CHRNB2 AR CAV3 CHRNA4 SLC9A3 ACADM GJA1 HIF1A MEF2C CHRM2 HSP90B1 TLX3 VIPR1 EGR1 VIPR2 AQP4 SOX2 LOC110384692;C4A;C4B_2;C4B VEGFA PKNOX1 NFKB2 CHRNB4 TSPYL1 GPD1L-1 POU3F2 NKX3-1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260410%WP5133%HOMO SAPIENS Non classical role of vitamin D ACE CYP2R1 ACE2 AGTR2 AGTR1 AGT CYP27B1 REN 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260410%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways NPC1-1 EBP SCP2 NPC2 DHCR7 SLC27A2 BAAT CYP27A1 AMACR ACOX2 SLC27A5 DBP THEM5 CYP7A1 ACOT2;ACOT1 ACOT9 EPHX2 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 HSD11B1 HSD11B2 ACOT6 ACOT4 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260410%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BECN1 ATG5 SH3GLB1 ATG3 UVRAG ATG9B ATG10 TSC2 AMBRA1 INSR ATG14 ATG12-1 MAP1LC3A CHAF1A ATG16L1 ATG4A TSC1 VMP1 ATG7 BCL2 INS;INS-IGF2 ULK2 ULK1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260410%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DROSHA DICER1 TARBP2 RAN INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260410%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling LMNA CEBPA CEBPB GSK3B TCF7 CCND1 CTNNB1 SREBF1 DICER1 TARBP2 SLC2A4 TOR1AIP1 ZMPSTE24 ADIPOQ EMD FNTA TLE1 HMGA2 ICMT RUNX2 AGO2 PPARG WNT10B TCF7L2 TCF7L1 CSNK1A1 AXIN1 LEF1 HES1 APC HES5 CDK6 CEBPD SPP1 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260410%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC2A2 AKR1B1 PYGL GYS2 GYG2 PGM1 GYG1 GALK1 GYS1 GALT GBE1 SLC5A1-1 GALE HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260410%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis CASP8 MAPK14 MAPK12 CASP3 MAPK13 MCL1 FADD BAD MAPK11 BAX APAF1 AKT1 BCL2L1 FASLG BCL2L11 TNF BCL2 BID CASP9 CASP7 BBC3 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260410%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC2H1 CREB1 ARHGDIB RAB5A CREB3L1 RAB5C DYNC2LI1 DCTN6 DCTN5 DYNC1I2 RAB5B DCTN2 ADCY6 GNAS-1 DCTN1 DCTN4 PRKACB-1 ARHGDIG ADCY3 AQP2 AQP3 PRKACA-1 CREB3L3 ADCY9 CREB3L4 CREB3L2 STX4 AVP DYNC1I1 NSF VAMP2 DYNC1H1 AQP4 AVPR2 RAB11A RAB11B DYNC1LI1 CREB3 DYNC1LI2 ARHGDIA CREB5 IL7 SIGNALING%WIKIPATHWAYS_20260410%WP205%HOMO SAPIENS IL7 signaling JAK3 BAD GSK3B PIK3R2 PIK3R1 IL2RG AKT1 MAP2K2;MAP2K1 FYN MAPK1 PTK2B STAT5A STAT1 STAT5B IL7 STAT3 IL7R MAPK3 JAK1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260410%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DROSHA DICER1 AGO2 ERI1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260410%WP183%HOMO SAPIENS Proteasome degradation UBE2D1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 H2AC4 PSMC2-1 UCHL3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSME3 PSME1 PSME2 PSMD10 PSMD12 PSMD11 RPN2 UBA7 PSMD13 RPN1 PSMA7 NEDD4 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 UBB;UBC UBE2B UBE2D3;UBE2D2 PSMB8 PSMB9 PSMA2-1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UBA1 H2AZ2;H2AZ1 IFNG UCHL1 UBE2D3-1 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP5414%HOMO SAPIENS IDO metabolic pathway GOT2-1 IFNG TDO2 KMO AADAT KYAT3 KYAT1 KYNU IDO2 TNF IDO1 SLEEP REGULATION%WIKIPATHWAYS_20260410%WP3591%HOMO SAPIENS Sleep regulation PTGDR PTGDS BTBD9 IL18 OXT-1 HCRTR2 HCRTR1 IL6 MTNR1B GHRH CRH GHRL ADORA2A SLC29A1 ADA MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 STAR CHRNB2 DRD2 TH DRD3 AHCY HTR2A UTS2R FOS NLGN1 OXTR NPY2R GRIN2A NPAS2 NPS DLAT CST3 CACNA1I ADORA1 DRD1 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260410%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders RRM1 DPYS PUS1 TYMS UPB1 TYMP DHODH NT5C NT5C3A RRM2B RRM2-1 DPYD TK2 CKB UMPS SERINE METABOLISM%WIKIPATHWAYS_20260410%WP4688%HOMO SAPIENS Serine metabolism PSPH SHMT2 PSAT1 PHGDH SHMT1 DHFR2;DHFR SRR TYMS INSULIN SIGNALING%WIKIPATHWAYS_20260410%WP481%HOMO SAPIENS Insulin signaling GAB1 PFKM ELK1 ARF6 MAP2K2;MAP2K1 PRKAA1 MAPK1 MAP2K7 HRAS MAPK4 MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 MAP3K3 JUN MAP3K1 SNAP25 MAPK14 MAPK12 MAPK10 MAPK13 IGF1R GRB2 RPS6KA1 MAPK7 SOS1 RAF1 PDPK1 SOS2 MAP3K12 RPS6KB2 IRS1 IKBKB AKT1 PIK3CD IRS2 MAP3K5 RPS6KA4 TSC1 FOXO1-1 RPS6KA5 FOS VAMP2 RAC1 PIK3C3 RAPGEF1 RHEB CRK PIK3R4 PIK3R2 PIK3R1 CBL SOCS3 SOCS1 EIF4EBP1 EIF4E SLC2A4 LIPE PTPN11 MTOR RPS6KB1 GYS2 GYG1 GSK3A MAP3K9 MAP3K6 MAP3K4 STX4 SHC2 SHC3 PIK3R3 FOXO3 MAPK8 MAP3K8 MAP2K5 MAP3K7 MAP3K10 MAP3K11 RPS6KA6 SLC2A1 PRKAA2 PRKCZ INSR SNAP23 RPS6KA3 GYS1 CAP1 MAP3K14 GSK3B MAP4K1 MAPK11 MAP4K2 MINK1 MYO1C AKT2 IRS4 KIF5B SGK1-1 ENPP1 MAP4K3 PRKCQ TRIB3 PTEN STXBP3 PIK3C2G MAP4K4 STXBP4 PIK3CB RRAD PIK3C2A STXBP2 PIK3CG PPP1R3A KIF3A XBP1 INPPL1 RAB4A CBLC EHD1 PRKCH ARHGAP33 CBLB PRKCB EHD2 TSC2 MAP3K13 PRKCD ARF1 PRKCA PTPRF RPS6KA2 FLOT1 FLOT2 TBC1D4 GRB10 RHOJ RHOQ GRB14-1 CYTH3 MAPK9 SGK3;C8orf44-SGK3 PRKCI MAPK6 MAP4K5 EGR1 SH2B2 INPP4A REG1B;REG1A PTPN1 SRF SORBS1 STXBP1 PFKL SHC1-1 PIK3CA AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260410%WP699%HOMO SAPIENS Aflatoxin B1 metabolism EPHX1 GSTM1;GSTM2-1 AKR7A2 AKR7A3 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A2 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260410%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX12 FPR2 LTC4S LTB4R CYSLTR1 CYSLTR2 LTA4H PTGR1-1 GGT5 EHHADH-1 TRPA1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 TRPV1 PTGR2 LTB4R2 ACOX3 PPARD PPARA ACOX2 DPEP1 ACOX1 ACAA1-1 ALOX5 ALOX15B HPGD ALOX15 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260410%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C5 C6 ACE2 C7 C9 C5AR1 FCN2;FCN1 C3AR1 MASP2 C3-1 C8A COLEC11 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling DNER JAG2 JAG1 PSEN1 HEY1 RRAS PSEN2 MAML2 RBPJ ADAM10 DLK1 DLK2 MFAP1 MFAP2 NOTCH1 DLL1 MAML3 LEF1 DLL3 DLL4 CHUK HES1 CNTN6 NOTCH2 NOTCH3 NOTCH4 MAML1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260410%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling PTK2 PIK3R2 GAB1 PIK3R1 LAMC2 LAMC1 EIF4EBP1 ITGB4 MAPK1 HRAS MAPK3 PTPN11 MTOR RHOA LAMA5 LAMA2 MAPK14 ITGA6 LAMA1 LAMA3 GRB2 SOS1 LAMB3 PRKCD PRKCA LAMB2 LAMB1 IRS1 SRC AKT1 IRS2 RAC1 SHC1-1 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260410%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair NASP-1 SUPT16H RNF168-1 H4-16 NAP1L1 SSRP1 RAD54L H4C1 H4C6 SETD2 XRCC6 XRCC5 RNF8 PRKDC RAD51 MDC1 TP53BP1 ATM NBN SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260410%WP3944%HOMO SAPIENS Serotonin and anxiety related events PLCD4 PPP3CA HTR1A ARC FOS NLGN1 CRH HTR2A GRIN2D PRKCB PLEK CRHR1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260410%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 ACE ACAD9 AGTR2 BCS1L AGTR1 REN NDUFAF1 NOX1 TLR7 DDX58 CGAS TBK1 IFIH1 PHB IKBKE MAVS STING1 NDUFB9 PHB2 TICAM1 CTSV;CTSL IRF3 TMPRSS2 TRAF3 ACE2 TRAF6 NFKB1 IRF7 NFKB2 ECSIT TLR3 NLRX1 TOMM70 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260410%WP4758%HOMO SAPIENS Nephrotic syndrome APOL3;APOL4;APOL1;APOL2 INF2 NPHS1 NPHS2 MYH9 LMNA LMX1B WT1 E2F3 ITGB4 ZMPSTE24 ITGA3 TTC21B COQ6 COQ2 PLCE1 PDSS2 LAMB2 COL4A4 COL4A3 SCARB2 COL4A5 CD151 PTPRO YARS1 CTLA4 PODXL GPC5 SYNPO CUBN TRPC6 ACTN4 PMM2 ALG1 CYP11B1;CYP11B2 WDR73 ARHGAP24 PAX2 SMARCAL1 CD2AP ARHGDIA EMP2 ANLN MYO1E ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260410%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 TRAF3 RELA NFKB1 IL1B PYCARD NLRP3 CASP1 SPINAL CORD INJURY%WIKIPATHWAYS_20260410%WP2431%HOMO SAPIENS Spinal cord injury MYC LTB4R PPP3CA E2F1 CDK4 C5 CDK1 EPHA4 MAPK1 MBP RGMA MAPK3 SLIT1 SLIT3 SLIT2 GADD45A CXCL8 ICAM1 TACR1 C1QB FOS RAC1 TP53 PTGS2-2 APEX1 CCL13;CCL2 NOS2 IL6 NGFR XYLT1 PLA2G2A-1 CDK2 AQP1 ZFP36 ROS1 SEMA6A OMG MIF EGFR PDYN BCAN MAG RTN4R KLK8 EFNB2 CHST11 PLXNA2 IL2 CXCL2;CXCL3;CXCL1-1 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 IL4 SELP NR4A1 GDNF PTPRA CSPG4 BTG2 NCAN TNFSF13B ANXA1 MMP12 VCAN IFNG GAP43 LTB IL1B AIF1 NTN1 ACAN PTPRZ1 E2F5 CCNG1 RB1 COL2A1 TNF NOX4 RHOC FOXO3 CASP3 FKBP1A VIM BDNF CXCL10 IL1A RTN4 LGALS3 CCR2 LEP MMP9 RHOA ROCK2 ARG1 CDC42 GFAP TLR4 SOX9 TGFB1 IL1R1 GRIN1 NOS1 CCND1 CD47 CDKN1B GJA1 PRKCA COL4A1 RHOB PLA2G5 PLA2G6 EGR1 AQP4 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260410%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation FGG F2 F13B FGB PLG FGA F13A1 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260410%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 SPHK2 SPHK1 SGPP2 SGPP1 ASAH1 KDSR IL9 SIGNALING%WIKIPATHWAYS_20260410%WP22%HOMO SAPIENS IL9 signaling JAK3 GRB2 PIK3R2 PIK3R1 CDK9 IL9 IL2RG IL9R MAP2K2;MAP2K1 MAPK1 STAT5A STAT1 STAT5B STAT3 MAPK3 JAK1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260410%WP4565%HOMO SAPIENS Neural crest cell migration in cancer NGFR SORT1 BDNF PAK2 PIK3R4 AKT3 EPHB1 AKT2 NGEF STAT3 CDH11 PAK3 PAK5 MMP2 PAK4 MMP9 JUN RHOA PIK3CB PIK3CG BUB1B-PAK6;PAK6 ARF1 NTRK2 EPHB6 TRIO EPHB2 PIK3CD AKT1 EPHB4 TIAM1 EPHB3 KIDINS220 MMP8 F2RL2 FOS PIK3R3 RAC1 PIK3R6 PIK3R5 PIK3CA PAK1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS1 TBXAS1 PTGS2-2 EPHX2 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260410%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance TRAF1 ACSL1 PRKCZ INSR PIK3R1 IRS1 PRKAG3 AKT1 IRS2 EIF2AK2 TNFRSF1A CD36 PDX1 SLC2A4 MAFA TNF CPT1B INS;INS-IGF2 ERN1 SMPD3 RPS6KB1 PPP2CB;PPP2CA MAPK8 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260410%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 AKT2 INSR MTOR RPS6KB1 RPS6 TBC1D4 IRS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260410%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness ITPR3 CREB1 PTK2 PLCG1 TNNC1 MAPK1 ITGB3 MAPK3 ITGAV RYR3 MFAP5 PRKCQ JUN MTHFR DEFICIENCY%WIKIPATHWAYS_20260410%WP4288%HOMO SAPIENS MTHFR deficiency ASMT DNMT3A EHMT1 NDUFAF7 CASP3 CHDH BHMT DNMT3B ALDH7A1 GRIN1 GRIN2D HNMT COMT PCYT1A CHKA MTHFR PEMT CHPT1 GRIN2A CASP9 CYCS-1 DNMT1 EHMT2 MARS1 TP53 NETWORK%WIKIPATHWAYS_20260410%WP1742%HOMO SAPIENS TP53 network MYC TP63 SUMO1 TNFSF10 OTX2 BOK GADD45A BAX PMAIP1 BCL2 ABL1 BID TP53 CDKN1A MDM2-2 ATM TP73 CDKN2A BBC3 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260410%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC3A2 SLC7A5 SLC1A5 NFE2L2 ATF4 KEAP1 SLC7A11 BASE EXCISION REPAIR%WIKIPATHWAYS_20260410%WP4752%HOMO SAPIENS Base excision repair POLB MPG OGG1 PARP1 PNKP UNG POLD3 POLD4 POLL PCNA NTHL1 POLD1 TDG POLD2 POLE MUTYH POLG RFC5 MBD4 PARP3 RFC3 HMGB1-1 RFC4 PARP4 POLE4 LIG1 RFC1 RFC2 XRCC1 TDP1 LIG3 APTX SMUG1 NEIL3 NEIL2 POLG2 POLE2 POLE3 ADPRS NEIL1 PARP2 FEN1 APEX1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260410%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators MMP1 IL17F IL17A MMP3 IL12B IL12A IL23A IL25 CXCL8 IL15 IL13 IL17D IL17C IL17B CCL13;CCL2 IL18 IL6 AREG CSF3 CSF2 CCL1 CSF1 EPO IL2 CXCL2;CXCL3;CXCL1-1 IL4 IL7 CCL4L2;CCL4L1;CCL4 TNFSF13B IFNG IL1B CXCL13 CXCL14 IL9 PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 TNF IL3 IL5 SPP1 XCL1;XCL2 PPBP CXCL10 IL11 CXCL11 CXCL12 CXCL9 CNTF CX3CL1 IL1A CCL23;CCL15 MMP9 CCL11 LIF CCL5 IFNB1-4 CXCL17 IL36A IL36B EBI3 IL36RN TSLP IL36G NFKB1 IL1F10 IL20 CCL19 IL26 CCL17 IL24 CCL25 IL19 CCL24 IFNK CCL22 CXCL5;CXCL6 CCL14 CCL21 LTA CTF1 CCL20 IL1RN IFNL2;IFNL3;IFNL1 CCL28 CCL16 CCL27 IL33 IL31 CCL26 IL37 TGFB1 IL10 OSM IL21 VEGFA IL22 CCL8 IL27 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260410%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC4 PRKACA-1 CRTC2 HDAC7 DNAJB1 SIK3 CREB1 SIK1;SIK1B HDAC5 SIK2 GNAS-1 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260410%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA G6PD RPE;RPEL1 TALDO1 DERA TP53 PGLS VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260410%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MMAA CBLIF MMAB TCN2 TCN1 MMUT MMACHC MMADHC MTR-1 CD320 CUBN FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260410%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LDLR CETP APOA4 LCAT LPL LIPC PLTP APOA2 VLDLR APOA1 SCARB1 LRP1 APOE DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260410%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CUL5 RUNX1 CBFB UBB;UBC ELOB ELOC-1 RBX1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260410%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CAMK1 NCK2 BAD NCK1 CSNK2A1;CSNK2A3 ELK1 DPYSL2 MAP2K2;MAP2K1 PRKAA1 MAPK1 HRAS MAPK3 MAP3K2 CYFIP1 JUN PPP2CB;PPP2CA MAP3K1 MAPK14 MAPK10 ACACB GRB2 YBX1 RPS6KA1 MAPK7 RAF1 CDK5 PDPK1 IRS1 IKBKB AKT1 IRS2 IKBKG NCF2 RPS6KA5 CAMK4 RACK1 IGF2BP1 GABRB3 RAC1 RPS6 CREB1 NGFR PIK3R2 PIK3R1 RAP1A EIF4EBP1 FYN EIF4E STAT5A SQSTM1 STAT1 STAT3 PTPN11 MTOR NTF3 RPS6KB1 CAMK2A TIAM1 CDH2 KIDINS220 SHC4 NSF SHC2 SHC3 FOXO3 MAPK8 CASP3 MAP2K5 BDNF NCF1 GRIA2 VAV3 VAV2 NGF GRIA3 PRKAA2 GRIN2B CDC42 CHUK NTRK1 NTRK2 NFKBIA RPS6KA3 TRAF6 NFKB1 RHOG SORT1 GRIN1 GSK3B CTNNB1 RAB3A CRTC1 GRIP1 CDKL5 FRS2 RASGRF1 FRS3 ADAM17 DOK5 SIRPA;SIRPB1;SIRPG KCNN2 EIF2S2 EEF2 EIF2S1 NFATC4 DLG1 JAK2 DOCK3 KSR1 SYN1 MAPT TSC2 KCNA3 PRKCD CNR1 PTPRF NCAM1 APC SH2B1 LINGO1 CFL1 NTRK3 SRC RANBP9 MARCKS MEF2A PLCG1 CDK5R1 RELA MEF2C MAPK9 PTK2B SH2B2 STAT5B SHC1-1 GRIA1 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260410%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 DDX1 DROSHA RAD50 MRE11 ATM NBN GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP4970%HOMO SAPIENS Galanin receptor pathway CDKN1B CREB1 IL6 YAP1-1 CRP POMC FOS SLC2A4 BCL2L11 VAMP2 ADIPOQ INS;INS-IGF2 VEGFA CDKN1C CDKN1A PPARG TAR SYNDROME%WIKIPATHWAYS_20260410%WP5362%HOMO SAPIENS TAR syndrome GPR89A;GPR89B HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3D DDIT4 PEX11B FURIN CLCN3 BCL2L13 SLC9A3R1 MTA1 MAGOH;MAGOHB FARP2 ZFHX3 UBE2I HDAC2 BRF1 DNM1 TNFRSF14 POLR3GL PYM1 CD247 PDZK1IP1 POLR3C ITGB1 POLR3F POLR3G MITD1 FLT3 LAMTOR1 CD160 HAMP TXN NFKB1 SIRT1 PIAS3 LCK PEX19 EGFR ITGA10 STAT3 IFNG CXCR4 MET ANKRD35 EIF4A3 CCAR2 SLC22A12 AKAP10 SLK HJV SUMO2 PDZK1 RBCK1 CFTR SLC22A4 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260410%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TGFB1 ZEB1 SNAI2 SNAI1 TCF4 HDAC2 HDAC1 CDH1 EZH2 FOXC2 KDM1A SUV39H1 SIRT1 SIX1 GRHL2 KLF8 ZEB2 PRRX1 ELF3 ELF5 GSC2 SUZ12 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260410%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGB1 VCAM1 ITGB2 ITGA4 SELE ITGA2 ITGB7 MADCAM1 ICAM1 SELPLG NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260410%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis ENDOG CASP8 PRF1 HTRA2 CASP6 DIABLO-1 CASP3 FADD BAK1 BAX APAF1 CFLAR AIFM1 FASLG BCL2 FAS BID CASP9 CYCS-1 CASP7 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260410%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 DRAVET SYNDROME%WIKIPATHWAYS_20260410%WP5200%HOMO SAPIENS Dravet syndrome FGF13 MAPKAP1 MAPK11 SCN3B SCN3A SCN1B SCN1A MTOR SCN8A SCN2A SCN4B SCN2B PRR5 KCNA2 CAMK2A PRR5L PCDH19 CHD2 HCN1 SNTA1 PRKCA AKT1 NFKB1 RICTOR CALM1 TNF MLST8 STXBP1 PIK3CA BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260410%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome PRKAG1 PRKAG2 MAPK11 PRKAG3 PRKAA1 MAPK1 G6PC1 SLC27A2 MAPK3 MAPK14 MAPK12 PRKAA2 MAPK10 MAPK13 ACACB ACACA ACLY PCK2 G6PC2 G6PC3 CRP MAPK9 PRKAB2 PRKAB1 MAPK8 ERYTHROPOIESIS%WIKIPATHWAYS_20260410%WP5607%HOMO SAPIENS Erythropoiesis IL3RA GATA2 HBD;HBB GATA1 HBG2;HBG1 HBZ GDF11 TFRC EPOR CD79A KIT EPO FASLG IL3 TF FAS KITLG HBA2;HBA1 PTPRC CD34 BLADDER CANCER%WIKIPATHWAYS_20260410%WP2828%HOMO SAPIENS Bladder cancer MYC DAPK2 DAPK3 E2F1 MMP1 PIK3R2 PIK3R1 EGFR CCND1 ARAF CDK4 THBS1 TYMP NRAS MAP2K2;MAP2K1 MAPK1 HRAS HBEGF MMP2 CDKN1A MMP9 CDKN2A BRAF ERBB2 DAPK1-1 KRAS RAF1 FGFR3 EGF CXCL8 SRC CDH1 RB1 RASSF1 UPK3A RPS6KA5 VEGFA TP53 MDM2-2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260410%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets IRF4 TCF4 TPO CSF2 SPI1 BATF3 CSF1 IRF8 ID2-1 STAT3 IKZF1 RUNX2 FLT3LG EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260410%WP410%HOMO SAPIENS Exercise induced circadian regulation SUMO3 UCP3 ERC2 SF3A3 RBPMS CRY1 ZFR CLOCK G0S2 IDI1 SUMO1 GSTM3 GFRA1 CEBPB NR1D2 QKI ETV6 PER1 PER2 CLDN5 H2BC15;H2BC3;H2BC11;H2BC12 VAPA PPP1R3C PSMA4 DNAJA1-1 CRY2 HSPA8 MYF6 TUBB3;TUBB6 ARNTL EIF4G2 PIGF GSTP1 KLF9 PPP2CB;PPP2CA HLA-DMA TAB2 NCKAP1 DAZAP2 CBX3-1 NCOA4 BTG1 AZIN1-2 TOB1 HERPUD1 PURA UGP2 STBD1 FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260410%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 CCR5 CCR6 STAT3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260410%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL18 IL6 NFIL3 TBX21 AHR AREG IL17A GFI1 IL4 EOMES IL7 BCL11B TOX IL12B IL12A IFNG IL23A IL1B IL25 IL9 TSLP HNF1A RORA IL15 ID2-1 GATA3 TNF IL13 ZBTB16 IL5 IL22 RORC IL33 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260410%WP5351%HOMO SAPIENS Kleefstra syndrome RXRA EHMT1 SMARCC2 H3-3A BAP1 KDM6A NR1I3 WDR5 SMARCD1 PAXIP1 SMARCD2 SMARCD3 DPY30 ASH2L PAGR1 RBBP5 MBD5 SMARCC1 ARID1A ACTL6B NCOA6 ACTL6A ARID1B SMARCA4 ASXL1 SMARCB1 SMARCA2 KMT2C ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260410%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction ACE2 NFKB1 TNFRSF1A TNF NOX1 IFNAR1 ICAM1 TNF ALPHA SIGNALING%WIKIPATHWAYS_20260410%WP231%HOMO SAPIENS TNF alpha signaling CASP8 CUL1 TRAF1 TAB3 MAP3K8 CASP3 FADD PSMD2 BAD MAP3K7 BIRC2 PLK1 BIRC3 CSNK2A1;CSNK2A3 TRADD NFKBIB APAF1 NRAS CFLAR GLUL MAPK1 MAP2K7 HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP3K3 JUN PPP2CB;PPP2CA TRAF2 MAP3K1 SKP1 DIABLO-1 TBK1 PRKCZ GRB2 KRAS SOS1 RAF1 CHUK TXN BAX IKBKB NFKBIA AKT1 IKBKG BCL2L1 MAP3K5 NFKB1 TNFRSF1A TAB2 TAB1 RIPK1 RAC1 BID TNFRSF1B BTRC TRAP1 CYBA MAP3K14 NOX1 CREBBP MAP4K2 HSP90AA1 NFKBIE CDC37 REL PYGL KSR1 OTUD7B SMPD2 RFK RIPK3 FBXW11 KSR2 MADD PTPRCAP NSMAF NOXO1 TANK RFFL MAPK9 TNF CASP9 NFKB2 TNFAIP3 CASP7 MAPK8 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260410%WP408%HOMO SAPIENS Oxidative stress response HMOX1 GSTT2B;GSTT2 SOD2 NOX1 NFE2L2 UGT1A1;UGT1A6 TXNRD2 TXNRD1 MAOA GPX1 GCLC MAPK14 CYP1A1 MAPK10 MGST1 JUNB SOD1 SP1 NFIX NFKB1 NOX3 XDH FOS NOX5 GSR NOX4 SOD3 CAT TXN2 NQO1 CYBB GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260410%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein SLC2A2 PCSK1 GCG GNAQ SLC5A1-1 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260410%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 XDH MB NOS3 AOX1 HBA2;HBA1 NOS1 HBD;HBB TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260410%WP5496%HOMO SAPIENS Targeted therapy in breast cancer ERBB4 PIK3R4 PIK3R2 PIK3R1 EGFR AKT3 NRAS MAPK1 AKT2 HRAS MAPK3 PIK3C2G PIK3CB PIK3C2A PIK3CG ERBB2 PIK3C2B KRAS RAF1 PIK3CD AKT1 PIK3R3 PIK3R6 ERBB3 PIK3R5 PIK3CA SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260410%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome LZTS3 DBNL HOMER1 BAIAP2 DLG4 ADGRL1 ARHGEF7 GRIN1 SHANK3 SPTAN1 MAP3K7 RAP1A ITGB1 ACTB-1 GRIA2 HRAS ABI1 CAMK2A ITPR1 GRIN2B CDC42 HCN1 GRM1 CTTN GRM5 TAB2 CTNND2 ARHGAP44 SYNGAP1 PAK1 SHARPIN GRIA1 DLGAP1 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260410%WP3601%HOMO SAPIENS Lipid particles composition LDLR APOC2 APOA2 APOA1 APOC3 CETP LCAT LPL APOE APOB PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260410%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases PKM MYL2 BECN1 PDK1 PAK2 PRPS1 KHK H3-3A BUB3 PGK1 SNAP23 AKT1S1 STAT3 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260410%WP5028%HOMO SAPIENS Glycine metabolism including IMDs LIPT2 LIPT1 GLDC GLRX5 AMT GCSH-3 DLD IBA57 HSCB LIAS NFU1 PNPO BOLA3 ISCU SHMT1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260410%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders TPP1 TERF1-1 H2AZ2;H2AZ1 H4-16 TERF2 H2AJ TERF2IP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H4C1 H2AB2;H2AB3;H2AB1 H4C6 H2BC15;H2BC3;H2BC11;H2BC12 ACD H2BC5 TINF2 H2BC1 H2AC14 H2BC21 H2AC20 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260410%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease FLNA MAPK14 FBN2 SMAD2;SMAD3 FBN3 SMAD4 POSTN AGTR1 LTBP2 NR2C2 LTBP1 TGFBR2 FBN1 ENG TGFBR3 ANGPT2 MAPK1 SERPINE1 MAPK3 CCN2 RUNX2 SHC1-1 TGFBR1-1 MAPK8 MONOAMINE GPCRS%WIKIPATHWAYS_20260410%WP58%HOMO SAPIENS Monoamine GPCRs ADRA1D ADRA1B ADRA1A HTR1A DRD2 DRD3 DRD4 HTR2A CHRM3 CHRM1 HTR4 CHRM4 HTR6 CHRM5 HTR7 HTR2B ADRB1 HRH1 ADRB2 HRH2 DRD5 HTR1E HTR1F CHRM2 HTR1D HTR1B HTR5A ADRA2C ADRA2B ADRA2A ADRB3 DRD1 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260410%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HDAC4 HCN2 KCNJ2 PTBP2 KCNQ1 IGF1 SRF GJA1 HCN4 HAND2 KCNE1;KCNE1B ERG CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260410%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 PDE3B GUCY1A1 ADORA3 ADORA2B PDE3A PDE4B PDE4A ADORA2A ADRA1D ADRA1B ADRA1A PPP1R12A RYR2 ADCY4 PPP1R12C ADCY1 ADCY8 NOS3 ADCY7 ADCY6 ADCY5 ADCY3 ADCY2 ADCY9 MYLK PPP1CB CALM1 PDE4D-1 CALM3;CALM1 RYR3 CALM2 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260410%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAPK14 RXRA SMAD2;SMAD3 SMAD4 PPP3CA IL6 DUSP1 VDR PPP3R1 MED14 CHUK NFATC1 NFKBIA IKBKB IKBKG RELA NFKB1 NR3C1 TNF MAP2K6 MAP2K3 MAP3K1 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP4478%HOMO SAPIENS LTF danger signal response pathway CD14 IL6 IL1B AGER IRAK1 IFNB1-4 LTF CXCL8 IRAK4 IL1A TRAF6 TLR2 NFKB1 MAPK1 TLR4 TNF MYD88 TREM1 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260410%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts XYLT1 HS3ST3A1 CHPF XYLT2 HS6ST1 HS6ST2 HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 CHST11 EXTL1 CHST12 B3GALT6 NDST4 NDST3 DSE CHST15 CHSY3 CHST13 CHST14 EXTL3 HS3ST3B1 CSGALNACT1 CHST7 CHPF2 B3GAT3 B3GAT2 GLCE B3GAT1 CSGALNACT2 HS3ST1 HS3ST2 EXT1 EXT2 CHSY1-1 UST CHST1 B4GALT7 CHST3 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260410%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TTBK2 KIF3B CEP192 CEP76 CPLANE1 CPLANE2 TMEM231 IFT20 TMEM17 SASS6 CEP83 CIBAR1 TTC26 TTC23 C2CD3 CBY1 EFCAB7 HSPB11 TCTN3 TCTN2 TCTN1 CC2D2A DYNLT1 CEP295 IFT46 KATNB1 TUBD1 TULP3 KIAA0753 OFD1-1 TUBE1 RABL2A;RABL2B CEP162 B9D1 CEP43 CEP44 DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 IFT52 TMEM107 BBS9 BBS7 IFT57 BBS5 BBS4 DYNC2H1 MKKS IFT140 IFT80 WDR35 LZTFL1 BBS10 IFT43 EVC BBS12 IFT81 TMEM216 WDPCP CILK1 CEP104 ARL6 ARL3 DYNLT2B DYNC2LI1 IFT74 ARL13B TMEM67 TTC21B RAB23 BBS2 EVC2 BBS1 WDR19 MIB1 SCLT1 IFT122 FUZ TTC8 MKS1 IFT27 CLUAP1 KIF3A INPP5E CEP19 CEP120 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP97 ARMC9 RPGRIP1L IFT88 TTC30A;TTC30B CEP20 TEDC1 TEDC2 FBF1 PIBF1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260410%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 FADS2 FADS1 ELOVL5 ELOVL2 ACOT2;ACOT1 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome RNF8 RNF168-1 ATR NIPBL MDC1 CBX3-1 ATM HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260410%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CREB1 BDNF PPARGC1A MAPK1 BCL2 NGF MAPK14 CAMK2B CAMK2A RPS6KA1 NRXN3 NRXN2 PRL NCAM1 SYT2 PRKCA NRXN1;NRXN3;NRXN2 HNRNPL SYT12 CCND2 RPS6KA5 CAMK4 CALM1 CAMKK1 CAMKK2 DRD1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260410%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction IRF9 IFNAR1 MAP3K7 TLR7 EIF2AK2 OAS3 STAT1 STAT2 JUN DDX58 MAPK14 TBK1 IFIH1 IKBKE MAVS CHUK OAS1 TICAM1 IKBKB NFKBIA IRF3 IKBKG TRAF3 TRAF6 NFKB1 FOS RIPK1 MYD88 JAK1 IFNAR2 MAPK8 TYK2 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260410%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HIF1A SLC2A1 CD36 TPI1 GPAT3 GAPDH-1 PPARG LDHA GPD1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260410%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CASK ATP2B1 ANK3 SNW1 DAB1 KCNMA1 KCNQ2 TERF2IP GRIN1 MAPK4 STXBP2 AGRN PRKCZ GRIN2B GRIK2 CAMK2G EPB41 EFNA5 RAP1GAP CLSTN1 CDH2 CSN3 GPHN MAPK9 CHL1 EPB41L1 EPB41L2 NCDN STX2 NEO1 CLASP1 NTNG1 GABBR2 PLCB4 CADM3 GABRG3;GABRG2 KCNJ6 CAV2 CADM1 APLP2 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260410%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation NFKB1 IL1B PYCARD TLR4 CTSB NOX1 CASP1 NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP61%HOMO SAPIENS Notch signaling CUL1 NUMB HDAC2 HDAC1 MAML2 RBPJ FBXW7 ITCH SKP1 NCOR1 MAML3 AKT1 NFKB1 SNW1 LCK JAG2 FHL1 JAG1 CIR1 GSK3B PSENEN PIK3R2 SAP30 PIK3R1 PSEN1 HEY2 NUMBL DTX1 APH1A MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B EP300 SPEN RING1 PSEN2 STAT3 TLE1 NCOR2 MTOR ADAM17 HES6 JAK2 NOTCH1 DLL1 DLL3 DLL4 HES1 HES5 SRC NOTCH2 NOTCH3 NOTCH4 MAML1 IL18 SIGNALING%WIKIPATHWAYS_20260410%WP4754%HOMO SAPIENS IL18 signaling CASP8 CASP3 CEBPB MAP3K7 PARP1 CFLAR PRKAA1 MAPK1 MAP2K7 NCF1 FAS MAPK3 ACACB GRIN2B IRAK1 CHUK BAX IKBKB NFKBIA SP1 TRAF6 NFKB1 TNFRSF1A NCF2 MYD88 BID TP53 IL37 IL18 LCK NOX1 GSK3B PIK3R1 CTNNB1 IL18RAP IMP3 CSN2-1 IRF1 SLC12A3 IL18R1 RPS6KB1 PTEN NFATC4 PRKCB ELAVL1 PRKCD PRKCA GATA1 MEF2A RELA MAPK9 HSPB1 FASLG TNF TICAM2 CYCS-1 IL2 SIGNALING%WIKIPATHWAYS_20260410%WP49%HOMO SAPIENS IL2 signaling LCK PIK3R1 CBL IL2RG SOCS3 MAP2K2;MAP2K1 FYN MAPK1 STAT5A IL2 IL2RA STAT1 IL2RB HRAS STAT3 MAPK3 CISH PTPN11 NMI RPS6KB1 JAK3 GRB2 MAPT SOS1 RAF1 RPS6KB2 AKT1 CRKL PTK2B STAT5B JAK1 FOXO3 SHC1-1 SYK RPS6 GAB2 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP5304%HOMO SAPIENS Cholesterol metabolism IDI1 FDPS MVK CYP51A1 DHCR24 MSMO1 LSS SQLE EBP PMVK SC5D MVD DHCR7 LBR HMGCR FDFT1 HMGCS1-1 SCARB1 HSD17B7 LRP1 PCSK9 LIPA APOE LDLRAP1 APOB LDLR ABCA1 MYLIP NPC1-1 STARD3 OSBPL5 SORT1 ACAT2 APOA4 LPL FABP2 SOAT1 VAPA ABCB11 STAR NPC2 APOC2 APOC1 CD36 VDAC1 SLC27A4 TM7SF2 NSDHL LIPG TSPO CYP27A1 ANGPTL8 ANGPTL3 LRPAP1 SAR1B NPC1L1 APOH MGAT1 CIDEB CETP MTTP LCAT CYP7A1 LIPC PLTP ABCG8 ABCG5 DGAT1 APOA2 APOA1 APOC3 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260410%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO1C1 SLC7A5 SLC7A8 SLCO3A1 SLCO4A1 SLCO1A2 SLC16A10 SLC16A2 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260410%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis HSD3B1;HSD3B2 POR HSD17B3 CYP11A1 SRD5A2 CYP17A1 CYB5A STAR HSD17B6 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260410%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYL2 CREB1 ITPR1 PTK2 ACTN1 VCL PXN LPP PLCG1 MYLK TJP1 MAPK1 ITGB3 MAPK3 ITGAV MFAP5 PRKCQ JUN THERMOGENESIS%WIKIPATHWAYS_20260410%WP4321%HOMO SAPIENS Thermogenesis FGFR1 ACSL3 NRAS PRKAA1 SIRT6 KDM1A HRAS AKT1S1 MAP2K3 MAPK14 ARID1A MAPK12 ACSL4 MAPK13 GRB2 RPS6KA1 KRAS SOS1 ATF2 GNAS-1 SOS2 SMARCE1 ADCY3 RPS6KB2 ADCY2 PRKACA-1 MAP3K5 SMARCA2 TSC1 RPTOR MLST8 PRKAB2 PRKAB1 RPS6 CPT1A CREB1 RHEB PRKAG1 PRKG1 PRKAG2 PRKAG3 FGF21 LIPE SMARCD1 MTOR SMARCD2 SMARCD3 RPS6KB1 PLIN1 MGLL PNPLA2 SMARCC1 ACTL6B ACTL6A ARID1B SMARCA4 KLB CREB3L3 ADCY9 CREB3L4 DPF1 CREB3L2 BMP8A;BMP8B DPF3 CPT1C NPR1 ADCY10 GCG CPT1B PRKG2 ACTG1 ZNF516 KDM3A KDM3B CREB3 UCP1 SLC25A29 CREB5 SLC25A20 BMP8B SMARCC2 PRDM16 PPARGC1A RPS6KA6 ACTB-1 PPARG PRKAA2 ADCY4 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 SMARCB1 RPS6KA3 ADRB3 ACSL1 ACSL6 ACSL5 MAPK11 CREB3L1 FRS2 CPT2 TSC2 CNR1 RPS6KA2 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 EPHX2 ALOX15 CYTOSINE METHYLATION%WIKIPATHWAYS_20260410%WP3585%HOMO SAPIENS Cytosine methylation MBD3 TET2 TET1 IDH1 IDH2 TDG MECP2 DNMT1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260410%WP3947%HOMO SAPIENS Serotonin and anxiety PLCD4 CAMK2B GABRA1 PPP3CA EEF2K HTR2A CRH PRKCB PLEK TRPV1 ADRA1A GRM1 HTR1A POMC FOS ARC FMR1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260410%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HGSNAT HPSE2 IDUA HEXB HEXA GNS SGSH GALNS NAGLU GLB1 HYAL1 HYAL2 HYAL4 IDS HPSE GUSB ARSB ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260410%WP554%HOMO SAPIENS ACE inhibitor pathway ACE TGFB1 AGTR2 AGTR1 AGT REN NOS3 ACE2 KNG1 CMA1 ATP6AP2 NR3C2 MAS1 CYP11B1;CYP11B2 CTSG BDKRB2 BDKRB1 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway IDI1 FDPS MVK CYP51A1 MSMO1 LSS SQLE PMVK SC5D MVD DHCR7 HMGCR FDFT1 HMGCS1-1 NSDHL MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260410%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 PTBP1 SIX4 CTDSP1 STK11 STRADB MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260410%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF1 SDHAF4 SDHC SDHD SDHA SDHB SDHAF2 SDHAF3 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2853%HOMO SAPIENS Endoderm differentiation SMAD2;SMAD3 DKK1 SFRP1 TBX21 LAMC1 CTBP2 NLK GLI2 NANOG;NANOGP8 GRHL2 MAP2K3 WNT3 PTHLH TCF7L1 ACACA BCORL1 EZH2 FOXO1-1 NR3C1 PIAS1 STAT1 EOMES TOX PBX3 NOTCH1 LEF1 SESN1 TET1 DNMT3B OTX2 POU5F1;POU5F1B BMP7 VAV3 FOXA1 APP SOX21 CEP250 DIP2A HOXA1 SOX7 WDHD1 SFMBT1 ZNF281 FOXH1 HNF1B CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 CTR9 GATA6 PRDM14 RTF1 MBTD1 EPB41L5 UBR5 GATA4 NKX2-1 BPTF NOG PABPC1;PABPC3 ATP8B2 SIAH2 TGFB1 FOXN3 GDF3 ZFHX4 TRERF1 DAB2 LHX1 SP4 NABP2 TAF4B DDAH1 PAF1 PLCH1 TCF7 PBX1 NODAL TRIM71 RARG ONECUT1 NCAPG2 CTNNB1 HOXC11 PHF6 CDC73 HHEX TRIM5 ZIC3 BMPR1A C1QBP CRTC1 JARID2 DUSP4 DUSP5 DUSP2 SLC2A12 PAX3 WNT8A PARP8 NME1 TOX3 AEBP2 MTF2 PAX9 SMAD4 AHDC1 CAND1 WWC1 BTAF1 LEO1 ASCC3 ZNF462 TCF4 KDM4A ELK4 EXT1 ELAVL1 ELP4 LRPPRC APC MAD2L2 TNRC6C RGS10 CEBPZ TAF5 NAA15 MIXL1 FOXA2 SOX17 CUL4B CER1 SOX2 ZBTB17 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260410%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes PPP3CA CLOCK ACAA2 LAMC2 LAMC1 MAPK14 MAPK12 MAPK7 KRAS LAMTOR3 IRS1 MYO1E PEDS1-UBE2V1;PEDS1 EIF4E FAR1 PDCD4 ADAR SUCLG2 RB1 LMNB2 EHMT2 DNMT3A EHMT1 DNMT3B TDG POLD2 BCL2 SLC25A13 HDAC4 GSTM4 MTRR CTNNB1 CBFB NOTCH2 MAT2A NRP1 E2F3 TXNRD1 CDKN1A NCOA3 PURA HMOX1 RHEB MYB ASH2L NOTCH1 FBXW11 SERPINE2 PLXND1 C1orf56 TUSC2 ARID4B CDKN1C ARF4-1 DCAF7 TXN2 ARHGDIA ANPEP CHORDC1 CDK5RAP1 GFPT1 MAP3K8 CDK5RAP3 FADS1 PGM1 VPS39 G6PD IFRD1 CEBPB GOLGA7-1 PISD MTHFD2 RAB34 PPIF WDFY1 MATR3 PPIB ANAPC1 DDX5 RAB5C TMED10 SLC1A4 ADIPOR2 SMAD1 AMIGO2 RTN4 CORO1C MRPL20 RDH10 RAB6A KCNN4 SAC3D1 SNX6 MPDU1 LRRC8A ATP6V1F PKM ATP6V0A1 CD164 PHC2 IDH1 TBCA TRAM1 IGF2R HNRNPM BCL6 TNFSF9 SFXN1 SLC25A1 ADPGK SNAP23 TNFAIP2 ATP2A2 MRC2 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 CSRP1 TMED3 TMEM109 ACP2 SH3BGRL3 NELFCD CTSC SCYL1 CAP1 ANXA2 RHOG MYLIP PTBP2 PRPF40A GAK SLC7A6 ZEB1 PDE3A CDCP1 RFT1 PPP3R1 FRG1 POM121;POM121C PTRH1 PNP-1 BRPF3-1 UNC93B1 CAPG TYMS PTPA DNAJB1 POLR2C USP1 SHOC2 PDLIM5 CDIPT SRSF10 SEC24A AP3D1 ARCN1 WDR11 ABCG2 POLE4 ATP6V0E2;ATP6V0E1 FMNL2 SMC1A CDKN1B PRKCI BACH1 E2F1 AP2A1 PLK1 ATAD3A;ATAD3B PXDN NEDD4 FADS2 ELOVL5 GNAI2 GNA13 CPOX LPL EGFR CYP1B1 BACE1 TPM4 TPM3 TPM2 TPM1 CYP51A1 SLC38A1 PTBP1 SLC38A2 PSAT1 CCND1 C1QBP GALNT1 CAND1 WNT5A TGFBR2 MET NAA15 CUL4B RRP8 RAVER2 ANKFY1 TMEM41B-1 HOXA5 MBNL1 CACNA2D1 FNDC3B FNDC3A SCAMP1 GTPBP3 WDR82 OTULINL VCAM1 ABCF2-H2BE1;ABCF2 HACD3 IQGAP3 KCNQ1 GRPEL2 CEP72 VTI1B MOV10 PPP5C STRN FERMT2 HOXD8 PANX1 ELMOD2 PAFAH1B2 VAMP3 PPP1R7 TAF9B TRMT1 TTC9C HIPK3 TMEM59 NFIA SNX15 NUCB1 PKN2 LAMTOR5 LY6K LTN1 ATRX MSI2 LCLAT1 IPO4 ABHD10 ABHD11 ARID1A POGLUT3 KPNA3 MYCN RARS1 STX7 RAB30 DMTF1 SYPL1 SRSF9 UAP1 SLC9A3R2 THEM4 SLC4A10 NCL-1 P4HA2 CDK6 CNOT9 CALCOCO2 SYNE2 EZH2 SYNE1 SNAP29 SIGMAR1 RAD23B IGF2BP1 MTPN SEC23A LUZP1 NUFIP2 PLAG1 HSD17B12 TP53INP1 SH3BP4 ZNF622 TERT SLC25A22 SLC25A24 SLC12A2 NPR3-1 ATG3 SLC12A4 MYO10 TM6SF1 SLC25A32 BET1 CPNE8 VEZT SRPRB-1 CHAF1A PWP1 TCL1A DHX57 ARFIP2 ARFIP1 CIAO2A SEC62 CCN1 ARL10 CSNK1D DHX40 CARHSP1 METTL7A-1 UBE2J1 FXR2 COMMD9 ATP6V1C1 HARS1 CDKN2A RAB27B BRI3BP FGF2 POLA2 NCEH1 ANP32B RCOR1 GFM1 PTPRJ MAGT1 MEOX2 COIL DHX15 GNL3L-1 GNPNAT1 TMED7 MRPS24 AP3B1 CSDE1 AGO3;AGO1 PTMA PRIM1 MRPS33 SSNA1 AKAP8 NAPG NT5E PGRMC1 MPZL1 MTX1 SPRYD4 YIF1B ATAT1 SPCS3 TPPP3 GPAM AXL TRIP13 GEMIN2 MCL1 NARS1 BDNF ARID2 ATG9A UBE4A CXCL12 CDKAL1 GPD2 GEMIN7 NF2 RAI14 SDCBP GAS2L1 TRPV6 UBE2S CHMP2A PICALM DOCK5 DOCK7 CHD1 UTP15 TMED2-1 HSDL1 MARS2 RBM19 BCKDHB PPP2R5C ITGA2 RCN2 RBMS1 NXN AURKB PDLIM7 RAB23 GALNT7 SLC4A7 UHRF1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A NT5C3A KIT CLDN1 COL4A2 PTPRF RHOB METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260410%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260410%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO1 FMO2 FMO4 FMO5 FMO3 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260410%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism CHDH ALDH7A1 SLC44A1 FMO3 MACROPHAGE MARKERS%WIKIPATHWAYS_20260410%WP4146%HOMO SAPIENS Macrophage markers CD14 F3 CD86 CD74 CD163 CD83 LYZ-1 CD68 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer MYC CHEK2 SMAD2;SMAD3 E2F1 BARD1 CDKN2B MMP1 BAD PLK1 CDC25A GAB1 CDC25B MSH6 MSH2 CDK4 ELK1 NOXA1 RASA1 CDK1 MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 CDKN1A JUN SPRY2 MAPK14 ARID1A GRB2 SOS1 RAF1 AKT1 CRKL TSC1 RPTOR RAP1B FOS JAK1 TP53 MDM2-2 RAPGEF1 RHEB CRK CDK2 RAP1A EIF4EBP1 ABCC4 STAT1 STAT3 PTPN11 SMARCD1 MTOR SMARCD2 SMARCD3 CDKN2A SMARCC1 ACTL6B ACTL6A ARID1B SMARCA4 RB1 PRKDC CASP9 PAK1 MAPK8 CASP8 CASP3 SMARCC2 HSD3B1;HSD3B2 BCL2 CHEK1 FOXA1 ATR SPRY1 BAX SPINK1 EIF4E1B SP1 FKBP5 ETV4 HSD17B1 HSD17B2 HSD17B3 HSD17B4 F13B HSD17B7 CYP17A1 CPN1 ERG CCND1 MAP4K1 KLK3;KLK2 AR RAD50 MRE11 ATM PTEN BRCA1 CDKN1B HGF DOCK1 TSC2 PXN NDRG1 PTK2B RICTOR ATF1 PIK3CA BLM INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260410%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions SMAD2;SMAD3 CD4 IL2RG CASP1 NKX2-2 MBP IL2RA IL2RB CNP IL12A MAPK14 IGF1R FOXP3 SSTR2 CTLA4 FOXO1-1 RAC1 JAK1 TYK2 PLP1 IL18 NOS2 IL6 ROS1 SOCS3 AREG EGFR STAT4 CCL1 STAT5A IL2 CXCL2;CXCL3;CXCL1-1 IL4 ITGB3 STAT1 STAT3 CSPG4 IFNG IL1B AIF1 TNF CD86 CD80 FOXO3 CD274 SPP1 HEXB CXCL12 CCR8 CCR6 LGALS3 ITGAV ITGA2 MMP9 CX3CR1 FOXO4 CDC42 HTR7 CD68 EBI3 IKZF2 LGALS1 NFKB1 CCN3 TGM2 NKX6-2 TLR4 APOD MYD88 NKX6-1 MCAM TNFRSF1B CD28 CCL20 TMEM119 IL1RAP OLIG1 OLIG2 IL33 SOX9 FAM20C TGFB2 SEMA3F TGFB1 KLRG1 P2RY12 MOG GALC PDCD1 IL10RB IL10RA IGF1 PTK2 PDGFA IL10 CD47 CD44 SIRPA;SIRPB1;SIRPG TGFBR1-1 IL12RB1 IL12RB2 GSDMD JAK3 PDGFRA TGFBR2 TGFBR3 STAT5B NLRP3 OSM VEGFA NFKB2 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway RXRA ALAS1 NCOA2 DNAJC7 EHHADH-1 ABCB1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT1A1;UGT1A6 PTPA PPARGC1A ABCC3 NR1I3 ABCC2 HSP90AA1 SMC1A NCOA6 SP1 GSTA3;GSTA5;GSTA1;GSTA2 NCOA1 FOXO1-1 SULT2A1-4 CYP2B6 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260410%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence TERT E2F1 CDK2 GBA S1PR1 S1PR2 S1PR5 RPP38 GLB1 DEGS1 CDK4 MAPK1 SPHK1 SGMS2 SGPP1 UGCG CERS4 MTOR ASAH1 CDKN1A KDSR CERS2 PRKCB PRKCA RB1 SPTLC1 SMPD3 PLCB1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260410%WP474%HOMO SAPIENS Endochondral ossification RUNX3 FGFR1 PTCH1 IHH PLAT GLI3 ADAMTS1 HMGCS1-1 BMP7 MMP9 THRA SLC38A2 PTH1R MMP13 PTHLH IGF1R FGF18 FGFR3 CTSV;CTSL AKT1 ALPL PRKACA-1 SOX9 TGFB2 HDAC4 TGFB1 IGF2 IGF1 ADAMTS4 GHR ADAMTS5 COL10A1 TIMP3 SOX6 NKX3-2 CHST11 SOX5 DDR2 STAT1 BMPR1A CAB39 SCIN SERPINH1 BMP6 RUNX2 MGP ENPP1 FGF2 KIF3A ACAN MEF2C COL2A1 PLAU CALM1 PTH FRZB STAT5B IFT88 VEGFA CDKN1C SPP1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2876%HOMO SAPIENS Pregnane X receptor pathway RXRA NCOA2 DNAJC7 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ABCB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NRIP1 UGT1A1;UGT1A6 PPARGC1A ABCC3 ABCC4 ABCC2 HSP90AA1 NR1I2 SRPX2 PSMC5 SRC GSTA3;GSTA5;GSTA1;GSTA2 NCOA1 FOXO1-1 NCOA3 SULT2A1-4 CYP2B6 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ANGIOGENESIS%WIKIPATHWAYS_20260410%WP1539%HOMO SAPIENS Angiogenesis PDGFB MAPK14 FGF2 PDGFRA PTK2 NOS3 CREBBP ANGPT1 SRC TEK AKT1 FGFR2 FLT1 HIF1A PLCG1 TIMP3 MAPK1 SMAD1 ARNT KDR VEGFA PIK3CA MMP9 TIMP2 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260410%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFB HIF1A VEGFC VEGFA HEY1 HES1 HIF1AN ATM SIGNALING%WIKIPATHWAYS_20260410%WP2516%HOMO SAPIENS ATM signaling CHEK2 CREB1 CDK2 CDC25C CDC25A MDM4 CDK1 RAD51 TLK1 MDC1 TP53BP1 RAD50 MRE11 CHEK1 CDKN1A ATM NBN JUN TP73 BRCA1 PIDD1 CCNB1 CRADD SMC1A RAD9A ATF2 GADD45A IKBKG MAPK9 CASP2 RIPK1 ABL1 BID CCNE1 TP53 MDM2-2 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260410%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1H4 VDR ABCB1 CYP7A1 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC3 ABCC4 ABCC2 NR1I3 SLC10A1 NR1I2 SULT2A1-4 SLC51A BAAT SLC51B CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MYO5A STK25 COPS8 SNED1 RTP5 GMEB1 RNPEPL1 SEPTIN12 ING5 FARP2 MAP1LC3C LRRFIP1 KIF1A ILKAP MYOG AQP12B GPR35 UGT1A1;UGT1A6 ITPK1 DUSP28 PPP1R7 OTOS ARL4C HAMP MYOD1 ATG4B COL6A3 USP40 AGXT ARF5 DTYMK ASB18 CENPA CYTH2 JUN CYTH4 GBX2 GPC1 SPP2 D2HGDH PRLH CYTH1 SEPTIN2 SEPTIN6 MAB21L4 MLPH CAPN10 PRL RAB17 RAMP1 RBM44 ASB1 IRF8 RAC1 ASCL1 TP53 RPS6 SH3BP4 PER2 MAP1LC3A EGFR MAP1LC3B2;MAP1LC3B-1 ITGB3 HES6 IL1B CXCR4 HES1 SCLY TRAF3IP1 PDX1 TNF CXCL11 CXCL12 BOK CFLAR ACKR3-2 NFKBIA TRAF3 GYS1 HDAC4 ABCA1 DISC1 PDCD1 PDGFA ILK DGKD NDUFA10 HDLBP HJURP ERFE KLHL30 GABARAPL2 PASK ARF1 IL13RA1 SEPTIN4-1 THAP4 EEF1A1 RRAGA RRAGC RRAGB MEF2A RRAGD IQCA1 CYTH3 MEF2C CALCA CALCRL TWIST2 CALM1 AGAP1 GABARAP COPS9-1 NEU4 ESPNL TRPM8 OR6B2 UBE2F MTERF4 RAB27A LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP1 LTC4S LTA4H PTGR1-1 GGT5 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DECR1 DPEP2 DECR2 ALOX5 GGT1 ABCC1 ALOX5AP WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members CUL1 SKP1 AXIN1 PLK1 APC PARP1 RBX1 CTNNB1 PARP10 TNK1 DVL1 DVL2 DVL3 BTRC TNK2 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260410%WP3676%HOMO SAPIENS BDNF TrkB signaling HOMER1 EEF2K CREB1 DLG4 BDNF RHEB GRIN1 GAB1 NRAS MAP2K2;MAP2K1 EIF4EBP1 MAPK1 ARC HRAS MTOR RPS6KB1 BRAF PIK3CG GRB2 ADCY1 RPS6KA1 KRAS MKNK1 SOS1 TSC2 NTRK2 AKT1 PLCG1 TRPC3 TSC1 TRPC6 SHC1-1 GAB2 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation MYC IRF4 LYN BCR E2F1 IL6 TLR1 TLR9 IL21R IL4R TLR8 TLR10 TLR7 TLR6 TLR5 SPI1 POU2F2 STAT3 CDKN1A STAT6 CDKN2A MEF2B;BORCS8-MEF2B CDKN1B CCND3 BCL6 TCF4 CD79A BCL2L1 LOC102723996;ICOSLG TLR2 TNFRSF13C CCND2 MEF2C NFKB1 SPIB IRF8 EZH2 CD79B SLAMF1 TLR4 POU2AF1 ID3 CD40 SYK TLR3 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260410%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 USP1 ID2-1 ID1 CDKN1A ARCN1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260410%WP2328%HOMO SAPIENS Allograft rejection CASP8 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CASP3 VIM CXCL11 CXCL12 IL17A CXCL9 C5 C6 IL1A C7 C9 IL2RA C3-1 FAS C8A IL12B IL12A PECR PRF1 CXCR5 PRKCZ CXCL8 FOXP3 HLA-DMA CTLA4 C1QB CCL19 IL13 CCL21 HLA-DPB1-1 CD28 LRRK2 C8B HLA-DOA HLA-DOB HLA-DPA1 GZMH;GZMB-1 TGFB1 BHMT2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DQB2;HLA-DQB1 AGTR1 C2 C1QC HLA-DMB CD55 HLA-DRA GABPA ABCB1 IL10 IL2 STAT1 IL4 GDNF HARS1 IFNG IL1B COL5A1 PDGFRA CD40LG CXCL13 FASLG TNF CD86 CD40 IL21 CD80 LOC110384692;C4A;C4B_2;C4B VEGFA IL5 IL22 CASP9 CASP7 CSNK2A2 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260410%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation IRF3 DDX58 TRAF3 TRAF6 TBK1 MAVS IKBKE IFNB1-4 TOMM70 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260410%WP4316%HOMO SAPIENS miRNA degrading enzymes PNPT1 EXOSC4 XRN1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260410%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IFNG IL1R1 IL18 ANKRD1 ZEB1 IFRD1 WDR1 MSTN MYOG DUSP14 ATF3 NR4A3 EIF4EBP1 IL1A EIF4E CCN1 JUND HBEGF VEGFA ADAM10 CREATINE PATHWAY%WIKIPATHWAYS_20260410%WP5190%HOMO SAPIENS Creatine pathway GATM SLC6A8 CKB OAT GAMT FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260410%WP5061%HOMO SAPIENS Fatty acid transporters FABP6 ACSL4 ACSL1 ACSL6 ACSL5 ACSL3 FABP1 FABP2 FABP3 FABP4 FABP9 FABP5 FABP7 CD36 ACSBG1 ACSBG2 SLC27A4 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260410%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC EGR1 POU5F1;POU5F1B SOX2 TRIM71 KLF4 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260410%WP5050%HOMO SAPIENS TCA cycle in senescence FH BRAF PDHA1 PDK1 PDP2 ME1 MDH1 ME2 TP53 GOT1-1 AUTOPHAGY%WIKIPATHWAYS_20260410%WP4923%HOMO SAPIENS Autophagy PIK3C3 ATG3 UVRAG ATG9A AMBRA1 PIK3R4 ATG14 PRKAG1 ATG12-1 PRKAG2 RB1CC1 ATG16L1 PRKAG3 MAP1LC3B2;MAP1LC3B-1 PRKAA1 ATG7 AKT1S1 ATG101 MTOR WIPI2 BECN1 PRKAA2 ATG5 DEPTOR RPTOR MLST8 PRKAB2 ATG13 PRKAB1 ULK1 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP3995%HOMO SAPIENS Prion disease pathway RXRA IRF4 CASP3 CREB1 PTK2 FGFR1 ELK1 SPI1 EP300 FYN MAPK1 POU2F2 BCL2 STAT3 MAPK3 RAD21 PDIA3 PRNP TBP HSPA5 SMC3 BCL11A PAX5 BATF RFX5 CTCF CHD2 NCAM1 MEF2C NFKB1 HSP90B1 EBF1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260410%WP697%HOMO SAPIENS Estrogen metabolism CYP1A1 GSTM1;GSTM2-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ARSD-1 STS ARSL COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT1A1;UGT1A6 CYP1B1 GSTA3;GSTA1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 CYP1A2 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260410%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport ST20-MTHFS;MTHFS SLC46A1 ALDH1L1 MTHFD2 ALDH1L2 FTCD QDPR ATIC TYMS MTHFD1 MTHFD2L FOLR1 GART MTR-1 SLC19A1 MTHFR SHMT2 SHMT1 DHFR2;DHFR IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260410%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis GLRX5 HSCB HSPA9 NFU1 NARF ABCB7 ISCU NUBP1 NUBP2 NFS1 LYRM4 FDX1 FDXR CIAO2B FXN MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260410%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY4 ADCY1 ADCY8 ADRA1D ADCY7 ADCY6 ADCY5 ADCY3 ADCY2 ADRB1 ADRB2 ADCY9 ADCY10 ADRA2C ADRA2B ADRA2A ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment IKBKG RELA NFKB1 IL6 TNF CHUK MUC1 NFKBIA IKBKB NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260410%WP4564%HOMO SAPIENS Neural crest cell migration during development NGFR BDNF PAK2 PIK3R4 AKT3 EPHB1 AKT2 NGEF STAT3 CDH11 PAK3 PAK5 MMP2 PAK4 MMP9 JUN RHOA PIK3CB PIK3CG BUB1B-PAK6;PAK6 ARF1 EPHB6 TRIO EPHB2 PIK3CD AKT1 EPHB4 TIAM1 EPHB3 MMP8 F2RL2 FOS PIK3R3 RAC1 PIK3R6 PIK3R5 PIK3CA PAK1 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260410%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer TIGAR PGAM1 PYCR2 PGD PAICS GLUD1;GLUD2 RPIA G6PD ALDOB TALDO1 PSAT1 ENO1 GAPDH-1 PYCR1 PGK1 PSPH PDHA1 TKT SHMT2 FASN LDHA FH PKM MDH2 SLC2A1 IDH2 DLST ACLY SDHB SUCLG2 ACO2 GOT2-1 IDH3A SLC1A5 GLS PFKL HK3 SLC16A3 GPI PDHB CILIARY LANDSCAPE%WIKIPATHWAYS_20260410%WP4352%HOMO SAPIENS Ciliary landscape COPS8 ECHS1 IFT20 ACSL3 TTC26 MSH2 HSPB11 CBS;CBSL DYNLT1 IFT46 MFAP1 RAC1 EXOSC4 WEE1 RB1 EXOC7 VIM SMC4 ARMC8 AFG3L2 MYL6 CD2BP2 INTU COPS7B GLB1 COPS7A MCM2 IQGAP2 NUP88 AAR2 CDR2 CTSA EXOC6B AIMP1 EHD3 WNK1 RANBP10 MYL6B TNKS1BP1 TMED1 RAB8A ZYG11B NUDC CNOT6L EXOC8 EIPR1 RAB3IL1 NME8 EXOC4 EXOC3 EXOC6 EXOC5 MAPRE2 EXOC2 EXOC1 PAFAH1B1 WDR26 EXOSC7 PGRMC2 EXOSC9 EXOSC2 WHRN COX6C TIPRL-2 NFKB1 MKLN1 GID4 GID8 YPEL5 DGKE EFTUD2 MAEA APMAP RAB2A ERF ANKS6 ARL8B SPATA7 CDH23 UBE2H TFAP2C TFAP2D UQCC1 NEK7 CNOT10 LSM4 COPS4 COPS3 IFT22 COPS6 COPS5 CNOT1 CTNNB1 COPS2 LCN2 DYNLRB2 DYNLRB1 TFAP2E;TFAP2B ZMYND19 MCM7 MCM8 MCM9 MCM10 RPGR EIF5B RBM14 NUP133 ARFGAP3 RABEP2 MCM3 MCM4 MCM5 MCM6 CCDC40 VPS4A USH1C EHBP1 RMND5B RAB21 RMND5A DNPEP LRPPRC SNRPB2 APC DCAF11 NDUFA9 RNGTT RANBP9 NDUFA5 GDI1 RAB14 VAPB XPNPEP3 GLA CALM1 NEFL NEFM IQGAP3 AGPAT2 HDAC2 HDAC1 CTBP2 DVL3 TFAP2A HTRA2 CNOT9 SNAP29 H3-3A CREBBP RHBDD2 RALB CAMK2A DYNC1I2 DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 IFT52 SSNA1 DYNC1H1 BBS9 BBS7 DYNC1LI1 IFT57 DCAF7 BBS5 CEP290 ARHGDIA BBS4 PSMD8 IQCB1 IFT140 PSMD7 IFT80 LZTFL1 IFT43 IFT81 DDX5 DOCK5 EFHC2 PSMD12 DYNLT2B PSMD13 IFT74 STOM BBS2 NEK8 YAP1-1 UBE2D3;UBE2D2 BBS1 PSMC6 LCA5 PSMC4 IFT122 FUZ BBIP1 TTC8 MKS1 IFT27 CLUAP1 POM121;POM121C TBC1D4 CEP97 IFT88 IQGAP1 TTC30A;TTC30B ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260410%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway HMOX1 RXRA GUCY1A2 GUCY1A1 GUCY1B1 IL6 MMP1 NOX1 NFE2L2 MMP3 GCLC IL12A IL1B CHUK CXCL8 KEAP1 GCLM SLC7A11 IKBKB NFKBIA GSTA3;GSTA5;GSTA1;GSTA2 IRF3 TMPRSS2 IKBKG RELA ACE2 NFKB1 TNF PRKG2 CCL13;CCL2 NQO1 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260410%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway SREBF1 MAP2K2;MAP2K1 PRKAA1 NR1H3 MAPK1 G6PC1 MAP2K7 HRAS SREBF2 MAPK4 MAP2K6 MAPK3 SCD FASN MAP3K2 MAP2K3 MAP2K4 MAP3K3 THRA MAP3K1 MAPK14 MAPK12 MAPK10 MAPK13 RPS6KA1 MAPK7 SOS1 RAF1 PDPK1 SOS2 MAP3K12 RPS6KB2 IRS1 AKT1 PIK3CD IRS2 MAP3K5 RPS6KA4 TSC1 RPTOR FOXO1-1 RPS6KA5 MLST8 PRKAB2 PRKAB1 RXRA PIK3C3 RAPGEF1 RHEB CRK MAPKAP1 PIK3R4 PIK3R2 LPL PIK3R1 PRKAG1 PRKAG2 CBL PRKAG3 EIF4EBP1 THRB EIF4E SLC2A4 MTOR RPS6KB1 ANGPTL8 SLCO1C1 CYP7A1 SLC16A2 GSK3A ABCG8 MAP3K9 ABCG5 MAP3K6 MAP3K4 SHC2 SHC3 EXOC7 PIK3R3 CYP2B6 FOXO3 MAPK8 MAP3K8 MAP2K5 MAP3K7 MAP3K10 MAP3K11 RPS6KA6 INS;INS-IGF2 SLC2A1 PRKAA2 INSR RPS6KA3 GYS1 SESN3 CAP1 MAP3K14 GSK3B MAP4K1 MAPK11 MAP4K2 MINK1 AKT2 IRS4 MAP4K3 PIK3C2G MAP4K4 PIK3CB PIK3C2A PIK3CG CBLC CBLB TSC2 MAP3K13 RPS6KA2 FLOT1 FLOT2 RHOQ MAPK9 PCK1 MAPK6 FBP1 RICTOR MAP4K5 TRIP10 PTPN1 SHC1-1 PIK3CA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260410%WP5053%HOMO SAPIENS Development of ureteric derived collecting system TGFB1 ANOS1-1 ETV5 BMP5 RARA CTDNEP1 VANGL2 FRAS1 FREM1 GFRA1 FREM2 FST RET BMPR2 RARG CCND1 GLI1 GLI3 GLI2 SMAD1 SHH WNT11 BMPR1A SIX1 GRIP1 SMO GDNF RARB BMP7 ITGA8 DCN MYCN BMP4 BMP2 SPRY1 GDF11 ETV4 CELSR1 HOXD11 HOXA11 SALL1 BMPER SIX2 PAX2 GPC3 EYA1 TGFB2 CRIM1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260410%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 TP63 RUNX3 DKK1 SFRP1 FOXE1 HR HOXC12 FOXQ1 CASP14 SOSTDC1 PHLDA1 IGFBP5 MSX2 SPINK6 SPINK5 KRTAP3-2;KRTAP3-3-1 GTPBP4 GLI2 ADAMTS20 SMAD1 DSG1 GAS1 WIF1 S100A4 DSG4 GPRC5D RBPJ DSC2 DLX3 KLK5 KLK4 FZD1 JUN KLK7 KLK6 CUX1 LRIG1 MSX1 ELANE GSDMA BMP4 KRTAP8-1 KLK13 KLK14 FOXN1 KRT19 LHX2 GJB6 NFATC1 KRT15 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 LGR5 CD200 NFKB1 FOS GATA3 NR3C1 CCN2 EGR2 SOX9 PERP IGF1 FST EGFR CTNNB1 BMPR1A BCL11B BMP6 ADAM17 CD34 IFNG PROM1 SMAD4 WNT5A NOTCH1 LEF1 DKK4 TCF4 NOTCH2 DKK3 SOX2 KITLG ZBTB16 FOSB CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260410%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II ACE CTSD CMA1 REN CTSG SPINA BIFIDA%WIKIPATHWAYS_20260410%WP5150%HOMO SAPIENS Spina bifida DNMT3A AHCYL2 MTR-1 DNMT3B AHCY MTHFR SHMT1 MAT1A MTRR MAT2B DNMT1 MTHFD1 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260410%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma MYL2 MYL3 PRKAR1B PLCB2 CREB1 PRKAR1A PRKAR2A ADCY4 PLCB3 ADCY1 ADCY8 ADCY7 ADCY6 GNAS-1 ADCY5 PRKACB-1 ADCY3 ADCY2 ADRB2 PRKACA-1 ADCY9 NR3C1 MYL4 PLCB4 MYL1 PLCB1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260410%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PIK3C3 ATG3 RHEB ATG10 PIK3R4 ATG14 ATG12-1 MAP1LC3A RB1CC1 ATG16L1 ATG4A SCP2 PRKAA1 ATG7 AKT1S1 ATG101 MTOR WIPI2 BECN1 ATG5 ACACA MECP2 TSC2 DEPTOR PLA2G6 WDR45 TSC1 RPTOR DCAF17 SPTLC1 FTL-1 WIPI1 MLST8 C19orf12 GTPBP2 CP ATG13 COASY FA2H ATG2A STK11 ATP13A2 ULK1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP23%HOMO SAPIENS B cell receptor signaling MYC LYN MAP3K7 NCK1 GAB1 ELK1 MAP2K2;MAP2K1 MAPK1 HRAS MAPK4 MAP2K6 VAV2 JUN BRAF MAPK14 GRB2 RPS6KA1 CDC42 BCL6 SOS1 PDPK1 RAF1 CHUK ATF2 IKBKB NFKBIA AKT1 IKBKG CD79A CRKL NFKB1 FOXO1-1 CD79B RAC1 SYK CD81 GAB2 BLNK GTF2I VAV1 KLF11 CR2 LAT2 CREB1 LCK BTK RAPGEF1 HCLS1 CRK CARD11 ETS1 DAPP1 BCL10 MALT1 GSK3B PIK3R2 CD19 PIK3R1 SH3BP2 CBL PTPN18 MAP4K1 NFATC3 TEC PIK3AP1 BLK CD22 RASGRP3 FYN PTPN11 PTPRC REL PTPN6 PIK3CG CAMK2A INPP5D PRKCB PLCG2 PRKCD PIP5K1A GSK3A PIP5K1B PIP5K1C PLCG1 RELA MAPK9 NFATC2 SHC1-1 MAX MAPK8 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260410%WP3298%HOMO SAPIENS Melatonin metabolism and effects ASMT CRY1 CYP2D6;LOC107987479;LOC107987478-1 MTNR1B CLOCK GSK3B PER1 PER2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ACHE CYP1B1 CRY2 AANAT MAP2 MTNR1A ARNTL CSNK1D MAOA CYP1A2 CYP1A1 ECE1 CAMK2A IRAK1 PRKCA ADRB1 TRAF6 TPTEP2-CSNK1E;CSNK1E NFKB1 EDN1 FOXO1-1 CALM1 SIRT1 CYP2C9;CYP2C19 APOE ADIPOGENESIS%WIKIPATHWAYS_20260410%WP236%HOMO SAPIENS Adipogenesis SMAD2;SMAD3 E2F1 SFRP4 AGPAT2 BSCL2 SREBF1 NR1H3 FOXC2 DVL1 SCD WNT1 PPARA CDKN1A DLK1 FZD1 WNT10B EPAS1 BMP4 NCOR1 BMP2 RBL1 PCK2 GADD45B GADD45A RBL2 IRS1 IRS2 NCOA1 FOXO1-1 CEBPD RORA GATA3 NR3C1 ID3 NAMPT EGR2 EBF1 DDIT3 KLF15 KLF5 RXRA RARA RXRG CREB1 IL6 LPL AHR MIF SOCS3 SOCS1 NRIP1 CNTFR CISD1 STAT5A GTF3A SLC2A4 STAT1 PRLR ZMPSTE24 STAT2 LPIN1 LIPE CFD STAT3 E2F4-1 LPIN2 NDN NCOR2 LPIN3 NR2F1 KLF6 BMP3 CYP26A1 BMP1 MEF2D CELF1 PLIN1 CYP26B1 PTGIS PLIN2 ASIP RETN SPOCK1 GDF10 KLF7 PNPLA3 GATA2 RB1 TNF UCP1 LMNA CEBPA CEBPB PPARGC1A ADIPOQ INS;INS-IGF2 FAS LEP PPARG LIF SP1 SERPINE1 GATA4 TGFB1 WWTR1 NCOA2 IGF1 CTNNB1 IRS4 PPARD TRIB3 STAT6 MEF2B;BORCS8-MEF2B AGT LIFR IL6ST MEF2A HIF1A HNF1A MIXL1 MEF2C PCK1 FRZB STAT5B OSM MBNL1 WNT5B GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2276%HOMO SAPIENS Glial cell differentiation MAG PLP1 GAP43 MBP MSN CNP TPPP EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260410%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells IL6 BIRC5 IGF1 CD63 SORBS2 EGF ETS2 EGFR SOD1 HSPB1 PDLIM5 TLR4 STAT3 KDR GATA4 PTEN MMP9 CD81 SPP1 RETINOL METABOLISM%WIKIPATHWAYS_20260410%WP5188%HOMO SAPIENS Retinol metabolism CYP1A1 ADH1C;ADH1B;ADH1A DHRS4 SDR16C5 RPE65 CYP2W1 DHRS9 AWAT2 RDH12 ALDH1A1 PNPLA4 RDH13 BCO1 LRAT AOX1 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP138%HOMO SAPIENS Androgen receptor signaling TLE5 CAV1 ETV5 KAT2B ZNF318 SMAD2;SMAD3 FKBP4 RNF6 RNF4 PSMC3IP SUMO1 BAG1 RLN2;RLN1 PATZ1 UBE2I DSTN NR0B2 DAXX HDAC1 STUB1 KDM1A LIMK2 SIN3A SMIM40 RHOA JUN ROCK2 ROCK1 RAD9A NCOR1 NR2C2 CDC42 SMARCE1 SP1 AKT1 PRDX1 NCOA1 FOXO1-1 RACK1 NCOA3 SIRT1 RAC1 NCOA4 CCNE1 PIAS3 MDM2-2 FLNA PIAS1 CREB1 NCOA2 PTK2 GSK3B PIK3R2 CARM1 PIK3R1 CREBBP CCND1 EGFR CTNNB1 EP300 AR FHL2 RAN STAT3 NCOR2 RUNX2 PTEN BRCA1 KAT5 SMAD4 BUB1B-PAK6;PAK6 RHOB SRC RB1 RELA CALR-1 RNF14 TGFB1I1 UBE3A PARK7 EFCAB6 ZMIZ1 TGIF1-1 PIAS4 PIAS2 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260410%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIA3 GRIA4 DLG4 GRIN2C GRIN2B GRIN1 GRIN2D GRIN3B NRXN1;NRXN3;NRXN2 GRIN3A NLGN3 NLGN4X;NLGN4Y NLGN2 GRIA2 NLGN1 GRIN2A GRIA1 NEUROINFLAMMATION%WIKIPATHWAYS_20260410%WP4919%HOMO SAPIENS Neuroinflammation ASCC1 MAPK14 NOS2 RELA FOS TLR4 CHUK MTOR JUN NFKBIA MAPK8 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260410%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C3 SULT1C2 SULT6B1 SULT4A1 SULT2B1 PAPSS2 SULT1B1-1 G6PD GSR PAPSS1 SULT2A1-4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260410%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS PPP3CA CASP3 RAB5A BAD NOS1 DAXX APAF1 CASP1 MAP2K2;MAP2K1 TOMM40 BCL2 DERL1 MAP2K6 PPP3CB SMIM40 PPP3CC SLC1A2 PRPH GPX1 CCS ALS2 MAPK14 SOD1 BAX BCL2L1 MAP3K5 TNFRSF1A TNF NEFL NEFM RAC1 BID NEFH CAT TP53 CASP9 CST3 GRIA1 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260410%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways CAMK1 HK2 PGM1 MAP2K5 HK1 TPI1 ALDOB ENO1 GAPDH-1 PGK1 ALDOA PFKM FLT1 PSPH AKT1S1 SHMT2 SHMT1 CDH13 FASN KDM5C BHLHE41 LDHA EFCAB3 PKM PLOD2 SLC2A1 ENO2 ENO3 PFKP PGM2 ENPP3 ACACB PBRM1 ACACA SDS ACLY TOX2 ALDOC RAPGEF5 SDSL PGBD5 LDHD LDHA;LDHC SSPN AKT1 TSC1 RPTOR MLST8 KDR PHGDH LDHB PDGFB PKLR KCNJ2 ZEB1 RHEB PSAT1 BAP1 SETD2 CREBBP EGFR PDGFRB EP300 SQSTM1 ME1 ARNT STAT3 MTOR PTEN KSR1 PDGFRA TSC2 VHL GRB10 DEPTOR HIF1A MDH1 VEGFA PFKL HK3 CEP290 GPI RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260410%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS ACE ITPR3 CAMK1 AGTR2 PLCB2 CREB1 AGTR1 REN ATF4 CREB3L1 STAR HSD3B1;HSD3B2 CMA1 CYP11A1 CALML6 CALML3 CTSG CALML4 CAMK2B CAMK2D AGT CAMK2A ITPR1 ATF2 CAMK2G ATF6B ITPR2 CREB3L3 CREB3L4 CAMK1D CREB3L2 CAMK1G CAMK4 CALM1 CYP11B1;CYP11B2 CALM3;CALM1 CYP21A2 CALM2 ATF1 CREB3 CREB5 GNAQ 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome CLOCK CD4 SDCBP ITGB1 GLI3 ARNTL ITGB2 SHH ITGA4 ITGA3 ITGA6 NRXN1;NRXN3;NRXN2 CD151 HLA-DMA LGALS3BP CD82 SPPL2C ACCS ALKBH3 C11orf96 C11orf94 TP53 TIMP1 LARGE2 CD53 CHST6 SLC35C1 REST MAPK8IP1 SLC25A17 B3GNT7 PRDM11-1 PEX16 MS4A1 B4GALT4 HLA-DMB IGSF8 PHF21A HLA-DRA ALX4 TP53I11 CD19 SYT13 VANGL1 B4GAT1 TSPAN18 IZUMO1-1 PEX3 CRY2 NDST1 HBEGF LEF1 CD63 EXT1 EXT2 CHST1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260410%WP4917%HOMO SAPIENS Proximal tubule transport SLC1A1 ATP6V1F SLC2A1 SLC3A2 SLC22A2 SLC12A4 AQP1 ABCB1 SLC4A2 SLC4A4 CA2 CA4 ATP6V1E1 ABCC4 SLC22A11 ATP6V1G1 ABCC2 SLC6A19 ATP6V0B SLC13A3 SLC6A18 SLC36A2 SLC34A1 ATP1B1 SLC5A8 ATP6V1C1 SLC7A7 ABCG2 SLC5A1-1 SLC7A9 ATP6V0E2;ATP6V0E1 SLC2A2 ATP6V0D2 ATP6V0C ATP6V1B1 SLC9A3 ATP6V1A SLC22A6 SLC47A1 SLC20A2 SLC3A1 SLC7A8 ATP1A1 SLC5A2 SLC6A20 SLC5A5 CLTRN SLC16A10 ATP6V1H ATP6V0A4 ATP6V1D FXYD2;FXYD6-FXYD2 SLC22A8 SLC22A7 SLC26A6 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260410%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB RXRA RARA RXRG RARB RARG IL11 SIGNALING%WIKIPATHWAYS_20260410%WP2332%HOMO SAPIENS IL11 signaling TGFB1 PIAS1 CREB1 BIRC5 IL11 PIK3R2 PIK3R1 SOCS3 PTPA MAP2K2;MAP2K1 FYN MAPK1 STAT1 HRAS BCL2 STAT3 MAPK3 PTPN11 RUNX2 RPS6KB1 ITGA2 JAK2 GRB2 RPS6KA1 YES1 PDPK1 RAF1 CHUK FES ICAM1 IL6ST SRC IKBKB AKT1 RELA IL11RA IBSP JAK1 PIAS3 ATF1 RPS6 TYK2 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation PTK2 GABARAPL2 ATG16L1 RB1CC1 RB1 MAP3K5 PTK2B WDR45B TNF GABARAP ATG13 ATG101 TP53 TRAF2 ULK1 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260410%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HSD3B1;HSD3B2 HSD17B1 HSD17B2 ESR2 HSD17B3 SLCO2B1 SLCO4C1 ESR1 SLCO4A1 SLCO1A2 CYP19A1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260410%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 ADIPOR2 ACACA ADIPOQ LEPR ADIPOR1 PRKAG1 PRKAB1 LEP CPT1A FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260410%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260410%WP3645%HOMO SAPIENS NAD biosynthetic pathways SIRT3 NADSYN1 NMNAT1 TNKS2 NAPRT PARP1 TDO2 SIRT6 CD38 SIRT1 PARP2 TNKS NAMPT QPRT SIRT4 SIRT5 PARP4 SIRT2 BST1 IDO1 ACMSD RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260410%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway MYC RS1 TNIP3-2 BIRC5 ANGPTL1 GRB7 BAD TIE1 NCK1 TNIP1 TNIP2 MSH2 RASA1 ITGB1 NRAS MAPK1 RAD51 HRAS MAPK3 MMP2 MAPK14 MAPK12 MAPK13 YAP1-1 GRB2 KRAS SOS1 CHUK ANGPT4 ANGPT2 BAX ANGPT1 IKBKB NFKBIA TEK AKT1 IKBKG NFKB1 FOXO1-1 RAC1 TP53 NOS2 CRK FN1 PTK2 NOS1 PIK3R1 EGFR MAPK11 CTNNB1 EIF4EBP1 STAT5A STAT3 PTPN11 ERBB2 STMN1 SRC PXN GRB14-1 RELA MAPK9 DOK2 STAT5B CASP9 PIK3CA CASP7 PAK1 MAPK8 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260410%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies KAT2B SMAD2;SMAD3 E2F1 LMNA CEBPA CEBPB TMPO LEMD3 HDAC1 CDK4 SREBF1 MYOD1 ACTB-1 CDKN1A PPARG WNT10B TCF7L2 TCF7L1 NAP1L1 BMP2 CSNK1A1 WNT7B CEBPD TGFB2 TGFB1 GSK3B TCF7 CREBBP MSTN CTSK CTNNB1 DICER1 TARBP2 ZMPSTE24 EMD MAOB FNTA TLE1 MAOA HMGA2 RUNX2 ICMT AGO2 JUNB NOTCH1 AXIN1 LEF1 HES1 APC HES5 RB1 TNFRSF11B SPP1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260410%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260410%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection CD3D MAP3K8 MAP3K7 NCK1 CD4 GRAP2 ITK DAG1 CDK4 CHP1 AHSA1 CD8A MAP2K2;MAP2K1 LCP2 RRAS ICOS MAP2K7 MAPK3 JUN PDK1 GRB2 SOS1 RAF1 CHUK IKBKB NFKBIA AKT1 IKBKG CTLA4 NFKB1 FOS CD28 ZAP70 LAT LCK PDCD1 MAP3K14 CARD11 BCL10 MALT1 GSK3B CBL IL10 CSF2 FYN IL2 IL4 PTPRC PRKCQ PTPN6 IFNG DLG1 CD40LG PLCG1 MAPK9 NFATC2 CALM1 TNF IL5 PIK3CA PAK1 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260410%WP272%HOMO SAPIENS Blood clotting cascade VWF FGG F7 F3 PLG SERPINB2 F9 F10 PLAT KLK1 F12 PLAU F11 F2 SERPINF2 F13B F5 FGB SERPINE1 F8 FGA KLKB1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260410%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome TET2 TET1 E2F1 BDNF HDAC1 MBP SIN3A PSIP1 GABRR2 CDON CNP RBFOX1 GRID1 TAP1 MYT1 GRIA3 HNRNPH1 GRIA4 GPRIN1 TET3 CTCF IGF1R NCOR1 ARHGEF26 YBX1 DLX5 DHX9 BCL6 DLX6 MECP2 FOXG1 NREP FUT8 MPP1 PRPF38A FUS GAD1 SP1 AKT1 FKBP5 OPRK1 POU4F1 HNRNPF TARDBP CEBPD EZH2 TAF1 CSRP1 RPS6 REST CREB1 IGF2 IGF1 GRIN1 GAMT MAG APOC2 MTOR SGK1-1 PTEN SMC3 NF1 FGF2 FGF3 SST FGF4 CAMK2A FGF5 SP3 MEF2C UBE3A POU3F2 GRIA1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260410%WP4742%HOMO SAPIENS Ketogenesis and ketolysis SLC16A1 SLC2A1 CPT2 BDH1 OXCT1-1 UCP2 ACAT1 SLC25A20 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5365%HOMO SAPIENS 4p16 3 copy number variation CKAP5 LETM1 TACC3 BCS1L C4orf48 NAT8L UBE2J2 H3-3A GAB1 PIK3R1 CBL MAPK1 MAPK3 FRS2 POLN FGF2 GRB2 SOS1 FGFR3 PLCG1 SLBP CLTCL1 NSD2 TMEM129 NELFB NELFCD FAM53A NELFA ERI1 NELFE PPAR SIGNALING%WIKIPATHWAYS_20260410%WP3942%HOMO SAPIENS PPAR signaling RXRB RXRA RXRG OLR1 ACSL1 HMGCS2 GK MMP1 LOC100509620;LOC112267859;AQP7 EHHADH-1 FABP1 LPL FABP3 FABP4 SCP2 ANGPTL4 NR1H3 CD36 ADIPOQ SLC27A4 ME1 SCD PPARD ILK PPARA CYP8B1 PPARG CYP27A1 PLIN1 SLC27A5 CPT2 FADS2 UBB;UBC PDPK1 PCK2 ACOX1 CYP7A1 ACAA1-1 PLTP PCK1 APOA2 APOA1 CPT1C APOC3 APOA5 SLC27A1 SORBS1 UCP1 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260410%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex CD3E HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 IL6 LCK HLA-DRA PRG3 CD2 CD4 IGLL5;IGLL1 CXCL8 MMP25 NKRF CD247 CD8B;CD8B2 CRP CD8A FYN LBP CD3G TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260410%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals HMOX1 CEBPB NFE2L2 PRKCA AIMP2 KEAP1 GCLM SLC7A11 GSTA3;GSTA5;GSTA1;GSTA2 EPHB2 MAF GCLC PIK3CA NQO1 MAPK8 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260410%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2B;BORCS8-MEF2B PAX7 MEF2A MEF2C HDAC5 MYOD1 EZH2 TLX3 ID2-1 TLX2 LEFTY2;LEFTY1 STAT3 TLX1 SRF SOX2 RUNX2 KLF4 MEF2D APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260410%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein MYC PIK3CG ITGA6 PTHLH BCL2L13 MCL1 BAK1 GSK3B BOK BAX GSK3A AKT3 BCL2A1 AKT1 BCL2L12 BCL2L1 ITGB4 BCL2L10 BCL2L2 BCL2L14 BCL2L15 AKT2 BCL2 BID 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260410%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome CASP8 MAZ ALDOA PCNA TBX6 MAP2K6 MAPK3 MAP2K3 PPARG PARP4 PPP2CB;PPP2CA TRAF2 EZR MSN TRAF6 NFKB1 NR3C1 TP53 SIAH1 BPTF DOC2A PRRT2 CCT6B CDIPT SPN PPP4R1 ESR1 PPP4R2 PAXIP1 PPP2R1A PPP4R4 PTEN CCT3 UNC13B REL PAGR1 CCT2 UNC13A IGFBP3 PPP2R5D PPP4R3A KIF22 PPP4R3B TLCD3B ASPHD1 CCDC6 TCP1 KCTD13 TMEM219 ZG16 KMT2D INO80E HDAC3 MVP GDPD3 SEZ6L2 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT7 CCT5 CCT4 IGBP1 QPRT C16orf92 C16orf54 CCT6A TAOK2 KMT2C YPEL3 G PROTEIN SIGNALING%WIKIPATHWAYS_20260410%WP35%HOMO SAPIENS G protein signaling AKAP9-1 AKAP12 AKAP11 PRKAR1B PPP3CA PDE8B PRKAR1A PDE8A PRKD3 GNAZ PDE1C GNG13 PDE1B PDE1A GNB2 AKAP7 AKAP6 GNB3 AKAP5 GNB5 AKAP4 PRKAR2B AKAP3 PRKAR2A AKAP1 GNA14 NRAS GNA15 GNGT1 RRAS KCNJ3 GNAL PDE7B PDE7A HRAS PPP3CC RHOA ADCY4 PLCB3 PRKCZ ADCY1 KRAS ADCY8 ADCY7 GNAS-1 ADCY6 ADCY5 GNAI3 PRKACB-1 ADCY3 GNG5 ADCY2 GNG4 PRKACA-1 GNAI1 GNAI2 GNG8 GNA13 GNA12 ARHGEF1 PDE4D-1 GNAO1 GNAQ GNB1 PDE4C PDE4B PDE4A PRKCG PRKCQ PRKD1 ITPR1 PRKCH SLC9A1 PRKCB PRKCE PRKCD GNA11 PRKCA ADCY9 PRKCI CALM1 AKAP8 AKAP10 AKAP13 GNG10 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260410%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1CA PPP1CC ATF4 MAP1LC3A PPP1R3C PPP1R7 EIF2AK2 PPP1R15A PPP1R15B BCL2 PPP1R13B PPP1R1B PPP1R11 PPP1R10 PPP1R8;STX12 PPP1R2-1 PPP1R9A PPP1R16B MBTPS1 PPP1R12A HSPA5 PPP1R14B PPP1R14C EIF2AK1 PPP1R3A PPP1R16A EIF2S1 EIF2AK3 XBP1 PPP1R3G PPP1R3F PPP1R12B PPP1R1A PPP1R12C PPP1R3B PPP1R3E PPP1R1C PPP1R3D PPP1R14D ATF6 MBTPS2 PPP1R14A PPP1CB ERN1 DDIT3 MAPK8 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260410%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CD14 MAPK14 MAPK12 CREB1 MAPK13 IL6 IL1B ATF4 MAPK11 IL10 CREB3L1 CREB3L3 RELA CREB3L4 NFKB1 CREB3L2 RELB TLR4 NFKB2 CREB3 REL CREB5 CCL13;CCL2 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260410%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection AKAP9-1 GUCY1A2 NOS2 GUCY1A1 CREB1 GUCY1B1 DLG4 PDE3A GRIN1 BAD NOS1 CNGB1 BCL2 TSPO IFNG CAMK2B CAMK2D IL1B GRIN2C CAMK2A GRIN2B GRIN2D NOS3 CAMK2G CNGA2 NPPB CNGA3 NFKBIA CNGA4 NPPA ACTN2 PDE2A RELA CNGB3 NFKB1 PPID CALM1 NPR1 TNF CNGA1 NEFL PRKG2 GRIN2A CASP9 CYCS-1 XIAP PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260410%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260410%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling ITPR1 HTR2A KRAS RAF1 ELK4 HTR2B RASGRP1 ELK1 NRAS MAP2K2;MAP2K1 MAPK1 MAPKAPK2 HRAS SRF MAPK3 RASGRF1 GATA4 GNAQ ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies JAK3 IL25 IL4R IL13RA1 OSMR IL2RG TSLP IL31RA IL1RL1 IL4 DEFB103A;DEFB103B FCER1A STAT3 MS4A2 IL13 CRLF2 IL5 FCER1G IL33 STAT6 TYK2 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260410%WP3871%HOMO SAPIENS Valproic acid pathway HADHA HADHB-1 CYP2B6 EHHADH-1 CYP2C9;CYP2C19 ACSM1 IVD HSD17B10 HDAC1 ABAT ACADSB CYP2A13;CYP2A6;CYP2A7-1 FERROPTOSIS%WIKIPATHWAYS_20260410%WP4313%HOMO SAPIENS Ferroptosis MAP1LC3C ACSL3 PHKG2 TXNRD1 SLC38A1 CBS;CBSL HMGCR FDFT1 TF GPX4 ATG5 ACSL4 SLC3A2 SLC7A11 TFRC FTL-1 SLC1A5 NCOA4 CP TP53 CTH STEAP3 SLC40A1 SAT2 CYBB SAT1 HMOX1 VDAC2-1 FTH1 SLC39A8 SLC11A2 ACSL1 SLC39A14 VDAC3 ACSL6 CHMP6 ACSL5 CHMP5 NOX1 IREB2 DPP4 FTMT MAP1LC3A PCBP1 PCBP2 GCH1 LPCAT3 MAP1LC3B2;MAP1LC3B-1 CISD1 ATG7 GCLC PRNP GSS POR COQ2 GCLM AIFM2 HSPB1 NOX4 BACH1 ALOX15 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260410%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy ITPR3 SMAD2;SMAD3 MPO FKBP1A PPIF MCU DAG1 GLI1 IL1A PRKAA1 TRPC1 FGB FGA MMP2 PLA2G4A MMP9 FGG PRKAA2 ELANE NFKBIA SSPN TRPC3 ITPR2 NFKB1 SIGMAR1 TRPC6 SERPINE1 CCN2 CYBB TGFB1 NOS2 AGTR1 IL6 PLA2G2A-1 PRG3 IL10 MCUB SCX ATP2A1 TOMM20 SGCA VDAC1 CAPN3 TRDN CACNB1 CACNB2 STIM1 ORAI1 CASQ1 SLC25A5 CACNA1F SARAF TGFBR1-1 CACNG1 CACNA1S DTNA GP2 SMAD4 SNTB1 IL1B CAMK2D ITPR1 TNNI1 TGFBR2 DMD RYR1 HSPA9 PLAU TNF NOX4 CASP9 CACNA2D1 SPP1 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260410%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway VAV1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TYROBP IFNG LAT PTPN2 ITPR1 GRB2 PRKCA CSF2 PLCG1 FYN LCP2 TNF HRAS RAC1 SYK PRKCQ CD34 PTPN6 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260410%WP4963%HOMO SAPIENS p53 transcriptional gene network TIGAR DDIT4 TRAF4 ALDH4A1 CDC25C CDC25A MSH2 APAF1 CX3CL1 PRKAA1 PCNA PML AKT1S1 ISG15 FAS NANOG;NANOGP8 CDKN1A GPX1 SLC2A1 PRKAA2 LIF GLS2 GADD45A BAX ICAM1 SLC7A11 RPTOR NCF2 MLST8 CCNE1 SERPINE1 PRKAB2 PRKAB1 ERCC5;BIVM-ERCC5 ULK2 TP53INP1 ULK1 CCL13;CCL2 ZMAT3 SAT1 PERP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MLH1 ADORA2B IRF9 CDK2 PRKAG1 PRKAG2 PRKAG3 XRCC5 THBS1 PMAIP1 RRM2B DDB2 MTOR BTG2 POLK PTEN PIDD1 ACAD11 IRF5 POLH NOTCH1 SERPINB5 SFN SCO2 TSC2 ADGRB1 CCNG1 ULBP1-2 XPC AURKA DRAM1 E2F7 RPRM DEPTOR ULBP3;ULBP1;RAET1G;ULBP2;RAET1L SIVA1 MGMT FUCA1 FANCC CPT1C TP53I3 FASLG TNF SESN1 BBC3 SESN2 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD11B1 HSD11B2 SRD5A2 CYP11B1;CYP11B2 CYP21A2 SRD5A1 AKR1D1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260410%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain MAP2K5 PDK1 YAP1-1 AMOT RAF1 TRIO AKT1 MAP2K2;MAP2K1 NFKB1 MAPK1 MAP2K7 RAC1 MAP2K6 MAPK3 MTOR MAP2K3 MAP2K4 PIK3CA RHOA GNAQ SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260410%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CASP8 MX1-1 SMAD2;SMAD3 TRAF5 FADD PPBP CXCL10 CXCL11 CXCL12 HDAC2 TRADD CXCL9 CD160 TRAF2 TFAP2A TBK1 CCL5 IFNB1-4 CXCL8 CXCL17 IRF3 TRAF3 CXCR2 TRAF6 IRF7 NFKB1 RIPK1 CXCL5;CXCL6 JAK1 IFNAR2 CCL13;CCL2 TGFB1 IL6 IL6R IFNAR1 TLR7 IL10 CSF2 EP300 CXCL2;CXCL3;CXCL1-1 STAT1 STAT2 CCL4L2;CCL4L1;CCL4 DDX58 MAVS CXCL13 TRIM25 PF4;PF4V1-1 TANK ACE2 CCL3L1;CCL3L3;CCL3;CCL18 TP53I3 IFIT2 TNF AP1G1 DHX58 BSG HAVCR2 LAG3 LARP1-1 IFITM3;IFITM2;IFITM1 NUP98 RAE1 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260410%WP1471%HOMO SAPIENS Target of rapamycin signaling DDIT4L DDIT4 ULK3 FKBP1A RHEB IDI1 MAPKAP1 PRKAG1 PRKAG2 PRKAG3 EIF4EBP1 PRKAA1 HMGCR AKT1S1 MTOR RPS6KB1 PRKAA2 PRR5 PRR5L CDC42 TSC2 PRKCA RRAGA RRAGC AKT1 RRAGB RRAGD TSC1 RPTOR RICTOR MLST8 RAC1 PRKAB2 PRKAB1 ULK2 ULK1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260410%WP1772%HOMO SAPIENS Apoptosis modulation and signaling CASP8 CASP10 CASP6 HRK CASP3 CAPNS1 PEA15 MCL1 PTRH2 BIRC5 FADD TNFRSF25 TNFSF10 BIRC7 NAIP BAD BIRC2 BAG3 BOK DFFB BIRC3 BMF DFFA BIK DAXX PTPN13 TRADD CASP5;CASP4 APAF1 CASP1 CFLAR IL1R2 BCL2 FAS MAPK3 SMIM40 JUN ENDOG HTRA2 DIABLO-1 IRAK1 BNIP3 BAK1 BAX IKBKB NFKBIA TRAF3 BCL2L1 HSPA1A;HSPA1B MAP3K5 TRAF6 NFKB1 TNFRSF1A AIFM1 FOS CASP2 RIPK1 MYD88 BID TNFRSF1B TP53 XIAP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A IL1R1 TOLLIP MAP3K14 BLK BCL2A1 BCL2L10 PMAIP1 BCL2L2 PIDD1 CDKN2A CRADD PRKD1 SEPTIN4-1 MADD AIFM2 FASLG BCL2L11 CASP9 CYCS-1 CASP7 BBC3 MAPK8 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260410%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PIK3R2 PIK3R1 PIK3CD CTLA4 CD86 PIK3R3 PTPN11 CD80 CD28 PIK3CA PPP2CB;PPP2CA PIK3CB PTPN6 GPCRS OTHER%WIKIPATHWAYS_20260410%WP117%HOMO SAPIENS GPCRs other LTB4R2 OR2M4 GPR61 GPR62 GRPR CELSR2 RXFP1 OR7E24-1 CELSR3 RXFP3 GPR176 GPR132 SMO OR2B6;OR2B2-1 ADGRE3 CCR2 EDNRA GNRHR GPR135 ADGRV1 ALG6 OR8G1;OR8G5 OR1F1 OR2H1-1 TAAR5 OR1J2 TAAR2 OR1N1 GPR162 HTR2A ADGRF5 VN1R1 OR1E1;OR1E2 CHRM3 OR6C3 OR3A1 OR10A5 HTR7 PTGFR C5AR2 GPR88 SSTR2 OR2A7;LOC107987545;OR2A4 CXCR3 GPR83 CXCR2 GRM1 GPR84 MCHR2 GHRHR HTR1F PROKR2 ADGRG1 HRH4 GPR183 OR6C2;OR6C68 OR5AC2-2 NTSR1 GPR17 P2RY13 P2RY11 OR2F1-2 GPR55 ADGRD1 GPR143 ACKR1 LGR6 ADORA3 OR2A5 ADGRL2 GPR18 ADGRL3 ADORA2A S1PR1 ADRA1D CCR5 DRD3 FSHR DRD4 CNR1 F2R CCKBR ADRB2 UTS2R CHRM2 CXCR1 CELSR1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260410%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CUL2 CBFB UBA3 NAE1 ZYG11B ELOB ELOC-1 RBX1 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260410%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling ZAP70 PPP3CA LCK PDCD1 GSK3B DYRK2 DYRK1A ITK RASGRP1 CD8B;CD8B2 RASA1 CD8A FYN IL2 PTEN PTPN6 PDK1 CSNK1A1 PRKCA GSK3A NFKBIA AKT1 PLCG1 CTLA4 NFKB1 NFATC2 CALM1 CD28 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260410%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2A MEF2B;BORCS8-MEF2B MEF2C CCND2 CAMK2D SRF MYOCD NKX2-5 KLF4 MEF2D ELK1 LEPTIN SIGNALING%WIKIPATHWAYS_20260410%WP2034%HOMO SAPIENS Leptin signaling BAD ELK1 MAP2K2;MAP2K1 PRKAA1 MAPK1 HRAS MAPK3 LEP RHOA MAPK14 ROCK2 PRKAA2 ROCK1 ACACB ACACA GRB2 RPS6KA1 CDC42 SOS1 RAF1 NOS3 CHUK IRS1 IKBKB SP1 AKT1 IKBKG NCOA1 NFKB1 FOXO1-1 RAC1 JAK1 RPS6 PDE3B CREB1 PTK2 GSK3B PIK3R2 PIK3R1 SOCS3 CFL2 KHDRBS1 SOCS2 EIF4EBP1 SOCS7 FYN KPNA4-1 EIF4E STAT1 STAT3 CISH PTPN11 ESR1 MTOR RPS6KB1 PTEN REL ERBB2 JAK2 PLCG2 SH2B1 GSK3A SRC PLCG1 RELA STAT5B LEPR PTPN1 SHC1-1 MAPK8 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5531%HOMO SAPIENS AKT signaling and ARTD family members MAPKAP1 GSK3B PIK3R4 PIK3R2 PIK3R1 PARP1 AKT3 PHLPP1 AKT2 MTOR PARP3 ATM PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PDK1 TSC2 PIK3CD AKT1 IKBKG TSC1 RPTOR FOXO1-1 RICTOR MLST8 SIRT1 PIK3R3 PIK3R6 PARP2 PIK3R5 PIK3CA STK11 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260410%WP325%HOMO SAPIENS Triacylglyceride synthesis GPAM PNPLA2 DGAT2 AGPAT2 GK LPL GNPAT LIPC GPD1 DGAT1 AGPS MOGAT3 MOGAT2 MOGAT1 AGPAT1 AGPAT3 LIPE AGPAT4 GK2 LIPF AGPAT5-1 PLPP3 PLPP2 PLPP1 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260410%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer MYC E2F1 BARD1 CDC25A CDC25B MSH6 HDAC1 E2F2 CDK4 E2F3 POLD3 CDK1 PCNA POLE CDC45 SUV39H1 SIN3A RFC5 RPA3 CHEK1 CDKN1A RFC3 RPA1 RFC4 RPA2 SKP2 MAPK13 RBBP4 CCND3 POLE2 RAF1 CDK6 SMARCA2 CCNE1 TP53 MDM2-2 ANLN H2AZ2;H2AZ1 PRMT2 CDK2 SAP30 CCNE2 RRM1 CCND1 CCNA2-1 TYMS MCM7 RBP1 DHFR2;DHFR WEE1 HMGB1-1 MCM3 TOP2A SMC3 MCM4 CCNB1 HMGB2 SMC1A SMC2 MCM6 CDKN1B KIF4B;KIF4A DCK TFDP1 TFDP2 TTK CCDC6 NPAT CCNB2 ORC1 HLTF RBBP7 STMN1 PLK4 CDT1 CDC7 FANCG POLA1 RB1 RABIF PRKDC PRIM1 ZNF655 FAF1 RRM2-1 ABL1 DNMT1 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260410%WP4925%HOMO SAPIENS Unfolded protein response TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A EIF2S1 EIF2AK3 XBP1 IL1B NFE2L2 ATF4 ATF6 MBTPS2 PMAIP1 RTCB TXNIP PPP1R15A BCL2L11 CASP2 BCL2 BID ERN1 TP53 DDIT3 MBTPS1 HSPA5 BBC3 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260410%WP404%HOMO SAPIENS Nucleotide metabolism SAT1 POLB PRPS1 MTHFD2 RRM1 POLA1 POLD1 HPRT1 RRM2B RRM2-1 PRPS2 ADSL NME2 POLG OAZ1 DHFR2;DHFR SRM IMPDH1 ADSS2 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 EPHX2 ALOX15 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260410%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFB6 NDUFA12 ACAD9 NDUFB5 NDUFB11 NDUFAF7 DMAC2 NDUFB4 NDUFAF2 NDUFB3 NDUFB2 NDUFB1 NDUFAF1 FOXRED1 TMEM186 TMEM70 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFV1 NDUFA8 NDUFA7 TIMMDC1 NDUFA6 NUBPL NDUFA3 NDUFC1 NDUFAF6 NDUFS6 NDUFAF4 NDUFAB1 NDUFS4 NDUFS3 NDUFS2 NDUFAF3 NDUFS1 TMEM126B NDUFS5-1 NDUFA13 NDUFA10 NDUFB9 NDUFA5 NDUFB8 ECSIT NDUFB7 NDUFB10 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260410%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism WNT16 BMP5 DKK1 CRY1 CLOCK PER1 BMPR2 RB1CC1 ARNTL SMAD1 BCL2 SEMA3A SMAD9 SMAD5 LEP BHLHE41 WNT10B RORB BECN1 ARHGAP4 PRKAA2 ATG5 FYCO1 LAMP2 BMP4 MEPE BMP2 BHLHE40 ATG4C CHRD DRAM2 CTHRC1 SEMA4D PLEKHM1 SP7 NFATC1 VCP-1 AKT1 TRAF6 ATG13 CTF1 NPAS2 TRAP1 ULK1 TGFB1 PIK3C3 IL6 ATG3 IGF1 ATG10 NR1D2 AMBRA1 ATG12-1 MAP1LC3A LRP5 CTSK ATG16L1 MAP1LC3B2;MAP1LC3B-1 EFNB2 CSF1 TNFRSF11A ATG7 SQSTM1 ATG101 MTOR BMP6 RUNX2 BMP3 HMGB1-1 SMAD4 JAK2 WNT5A NOTCH1 CALCA PTH SOST TNFRSF11B IL3 TNFSF11 SERPINF1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260410%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome HERC2 E2F1 CDKN2B BDNF MDM4 CDK4 NUP88 RNF8 INS;INS-IGF2 CYFIP1 GABRR2 TUBGCP2 FMR1 TUBGCP5 NIPA1 NGF TUBGCP6 TUBGCP3 MSX1 TUBGCP4 NIPA2 DLX5 PRKCZ AHCTF1 NUP107 NUP188 GABRR3 CDK6 GLE1 GABRR1 NUP62 NDC1 NUP214 SEC13 GABRB3 SNRPN CGA NUP210 FSHB TP53 TACR3 NUP93 GABRG3;GABRG2 NUP50 MDM2-2 FEZ1 FEZ2 GABRD SNURF NUP54 OCA2 OXT-1 NUP205 SLC45A2 MAGEL2 SEH1L GABRA5 GHRH NUP58-2 LHB UBE2N GHRL GABRG1 POM121;POM121C ATP10A AAAS NUP160 NHLH2 CCND1 NUP42 NUP85 NUP43 RANBP2 CDKN2C NUP155 EIF4E NUP153 CDC6 NUP35 MKRN3 GNRH1 NUP37 NDN KISS1 TYR NUP133 CDKN2A RB1 CCND2 POMC PCSK1 TPR UBE3A NUP98 BBS4 RAE1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260410%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CCL11 IL6 IL1B OLR1 BDNF CCL5 GFAP CRP TAC1 CX3CL1 CHI3L1 CCL23;CCL15 TNF NEFL TREM2 GRN TREM1 ADM TSPO CCL13;CCL2 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260410%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2H POLR2I POLR2L POLR2M TAF12 TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 ERCC3 TAF8 TAF7 TAF6 MED31-1 TAF4 ELK1 TAF3 TAF2 MED15 THRA CDK8 TAF1 NELFB NELFCD NELFA NELFE MED14 POLR2C GTF2B MED19 MED16 MED18 TBP MED17 MED12 MED11 MED13 MED10 MED8 MED1 MED9 GTF2F1 MED27 MED4 MED26 MED29 MED6 MED7 MED23 MED22 MED25 MED24 TAF5 MED21 MED20 GTF2A1 MED28-1 CTDP1 TAF9 GTF2E2 CCNC-1 POLR2A MED30 POLR2B POLR2D POLR2E POLR2F POLR2G METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260410%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway CHDH BHMT AHCY MAT2A MAT1A TXN MAT2B TAT ODC1 AMD1 MTR-1 APIP MRI1 MSRA IL4I1 MTAP ADI1 SRM MSRB2 SMS MSRB3 ENOPH1 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260410%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MYC CLPP LARS1 LONP1 LONP2 EIF2A PHB TSC2 ATF4 PHB2 IRS1 AKT1 TSC1 FOXO1-1 MTOR HSPD1 TRAP1 GDF15 SLC7A7 MARS1 OMA1 SESN2 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP4784%HOMO SAPIENS Proteoglycan biosynthesis CSGALNACT1 B3GAT3 SLC35B3 SLC35B2 XYLT1 CANT1 BPNT2-1 EXT1 EXT2 CHSY1-1 XYLT2 B4GALT7 CHST3 SLC26A2 PAPSS2 B3GALT6 CHST14 EXTL3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260410%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 TOLLIP TLR1 TLR9 TLR8 TLR7 TLR6 TLR5 MAPK1 RELB REL TBK1 IRAK1 IKBKE CHUK IRAK4 TICAM1 TIRAP IKBKB IRF3 IKBKG TRAF3 RELA TRAF6 TLR2 NFKB1 IRF7 TLR4 MYD88 NFKB2 TICAM2 TLR3 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260410%WP3529%HOMO SAPIENS Zinc homeostasis MTF1 SLC30A9-1 SLC39A8 SLC39A14 SLC30A10 MT2A SLC39A9 SLC39A6 SLC39A5 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC30A4 SLC39A11 SLC39A10 SLC39A13 SLC30A1 SLC39A12 MT3 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260410%WP1533%HOMO SAPIENS Vitamin B12 metabolism MPO MAT1A SERPINA3 PLAT MTR-1 SAA2;SAA1 CBS;CBSL INS;INS-IGF2 SHMT2 FGB FGA SAA2-SAA4;SAA4 FGG F7 CCL5 PLG INSR HBD;HBB SOD1 ICAM1 CRP NFKB1 CUBN MTHFR SCARB1 SERPINE1 SOD3 HBA2;HBA1 CTH ALB APOE CCL13;CCL2 APOB LDLR ABCA1 MCEE LRP2 SOD2 IL6 MTRR CBLIF MMAB TCN2 TCN1 MMUT F2 IFNG IL1B RELA APOA1 TNF NFKB2 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260410%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNA FLNB FLNC NPHP1 MAPK1 PTK2B RPGRIP1L MAPK3 INVS BCAR1 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260410%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMAD4 SMAD1 SMURF1 BMP2 TOB2 BMPR1A SMAD6 BMPR1B TOB1 RUNX2 BMPR2 NOG ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260410%WP1993%HOMO SAPIENS Angiogenesis overview GRB7 BAD FGFR1 NRP1 MAP3K7 NCK1 ROBO1 DAG1 ELK1 MAP2K2;MAP2K1 MAPK1 MAP2K6 SEMA3A MMP2 MAP2K4 MMP9 MMP14 MAPK14 SLIT2 WAS GRB2 CDC42 KRAS SOS1 PDPK1 RAF1 NOS3 ATF2 ANGPT1 TEK PIK3CD AKT1 KDR RAC1 CRK ROBO4 SHB TIMP4 SEMA4A BMX MAPK11 F2 PTPN11 FRS2 MTOR TIMP2 FGF1 PRKCA APC VHL PLA2G1B SRC PXN GRB14-1 PLCG1 PTK2B DOK2 PLXND1 NOX4 VEGFA IQGAP1 SHC1-1 PAK1 MAPK8 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260410%WP288%HOMO SAPIENS Nod like receptor NLR signaling ERBIN IKBKG RELA CD40 MAP3K7 CHUK IKBKB MAPK8 EPHB2 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling RAPGEF1 CRK PTK2 GAB1 MAP4K1 RAP1A ELK1 RASA1 ITGB1 MAP2K2;MAP2K1 MAPK1 HRAS STAT3 MAPK3 PTPN11 PTEN JUN ITGA1 HGF GRB2 DOCK1 SOS1 RAF1 MET SRC PXN CRKL PTK2B RAP1B FOS PTGS2-2 PIK3CA PAK1 MAPK8 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260410%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA RARA VDR OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260410%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development DKK1 NOTCH1 SP7 DMP1 DSPP CTNNB1 NOTCH2 ALPL NOTCH3 NOTCH4 HNF1A SOST BMP7 RUNX2 KLF4 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260410%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult TAL1 LMO2 HBA2;HBA1 HBD;HBB GATA1 HBG2;HBG1 HBZ LDB1 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling FN1 PTK2 AREG EGFR MAPK11 AKT3 ITGB1 NRAS MAP2K2;MAP2K1 MAPK1 HRAS ITGA1 MAPK14 MAPK12 MAPK10 MAPK13 COL1A1 GRB2 KRAS SOS1 RAF1 SRC PXN PIK3CD TLN1 MAPK9 MAPK8 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260410%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation CD3E CD3D MAP3K8 GRAP2 CD247 ITK CD8A LCP2 GRB2 PDPK1 CHUK IKBKB NFKBIA SMARCB1 AKT1 IKBKG TRAF6 NFKB1 GNA13 CD28 VAV1 ZAP70 CUL5 LAT LCK MAP3K14 CARD11 BCL10 MALT1 PIK3R2 PIK3R1 ELOB MAP4K1 PCBP2 SOCS1 DGKA TMEM222 ARIH2 UBASH3A DGKZ RASA2 RNF7 ZFP36L1 RPRD1B SH2B3 SH2D1A FIBP PRKCQ CD5 MEF2D REL PTPN6 RHOH CDKN1B CBLB AGO3;AGO1 PLCG1 RELA TNFAIP3 CD3G NDUFB10 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260410%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid ALOXE3 PTGS1 CYP2C9;CYP2C19 PTGS2-2 GPX4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EPHX3 CYP1A2 ALOX15 ALOX12B DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260410%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE ACE2 AGTR2 AGTR1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260410%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation PECR ACADVL ACSF2 CPT2 ACADS ACSL4 ACADM ACSL1 ACADL ECI1 EHHADH-1 ACSL3 HADH SCP2 HADHA SLC25A20 CPT1A CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260410%WP530%HOMO SAPIENS Cytokines and inflammatory response TGFB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IL6 IL11 HLA-DRA CD4 PDGFA CSF3 IL10 CSF2 IL1A CSF1 CXCL2;CXCL3;CXCL1-1 IL2 IL4 IL7 IL12B IFNG IL1B IFNB1-4 IL15 TNF IL3 IL13 IL5 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260410%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CASP8 TGFB1 SMAD2;SMAD3 CASP3 PDE1B PPP3R1 NOS1 MCU APAF1 MAPK1 MTOR TGFBR1-1 BRAF SMAD4 CRYZL2P-SEC16B;SEC16B G3BP1 FFAR3;GPR42 TRPV5 RGN BAK1 RAF1 BAX AKT1 MAP3K5 CALCA TNFRSF1A PTH TNFSF11 ACTA2 CASP9 PIK3CA SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation MYC ETV5 COPS8 CRY1 CLOCK IFT20 PARD6B BIRC2 PER1 TTC26 RB1CC1 CDK1 ITPK1 HSPB11 SREBF1 PRKAA1 NR1H3 ARNTL G6PC1 IFT46 JUN NR1H2 RPTOR IRF8 MLST8 ATG13 TP53 PRKAB1 CREB1 PRKAG2 CFL2 PRKN TFE3 CRY2 TFEB STAT3 ATG101 MTOR HES6 IL1B FHOD1 PRDM1 FERD3L ALKBH5 MPRIP DENR TRAF3IP1 MIGA2 IFT172 MIGA1 DRC3-1 RNF41 TOM1L2 PARD3 LLGL1 IFT52 DRC7 FLCN ATPAF2-2 FLII TNF GPR85 PEMT CLEC16A PLD6 RAI1 RAB39B IFT57 HBP1 DRC1 TNFRSF13B CLTC GDI2 CLTB WDR41 CLTA IFT80 EFCAB2 ARG2 RMI2 RMI1 IQCD ARMC8 TOP3A TCTE1 IQCG SMCR8 GAS8 C9orf72 IFT81 GPS1 COPS7A MIEF2 RASD1 NT5M APBB1 FNIP1 FNIP2 LIMK1 FBXL13 MYO16 RAB10 MYO15A SHMT1 DRG2 CCDC65 RAB8A RHOA IFT74 LDHA FOXA1 APP ROCK1 YAP1-1 BCL6 WDR26 BAX NFKB1 MKLN1 IFT27 GID4 TLR4 MYD88 CLUAP1 MAEA ULK1 WWTR1 TOLLIP MAP3K14 COPS4 COPS3 CARM1 IFT22 COPS6 COPS5 COPS2 GRIP1 PTEN PPP1R12A MED9 RMND5A RRAGA PPP1R14A RANBP9 USP8 IQCA1 RELA FOXA2 PRKCI PCK1 BCL2L11 IFT88 TTC30A;TTC30B BLM MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260410%WP129%HOMO SAPIENS Matrix metalloproteinases MMP1 TIMP4 MMP25 TIMP3 MMP3 MMP7 TCF20 MMP2 MMP21 MMP20 TIMP2 MMP9 MMP24 MMP27 MMP28 MMP12 MMP14 MMP10 MMP13 MMP11 MMP16 MMP15 MMP17 MMP19 MMP8 TNF BSG TIMP1 MMP23B ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260410%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FABP6 ABCC3 ABCC4 ABCC2 SLC10A1 SLC10A2 SLC51A SLC51B ABCB1 ABCB11 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260410%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells BRAF HNRNPH1 RAB5A PDCD6IP KRAS RRAS2 MRAS RAF1 RAB5B ARAF NRAS RAB5C RRAS MAPK1 HGS HRAS MAPK3 RAB27A EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260410%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC2H1 CASP8 CASP3 SYPL1 RAB3B DYNC2I2 TRAK1 DCTN1 RHOT1 DYNC2I1 BAX KIF1B MFN2 RABAC1 SNCA RAB7A MAP2 TUBB3;TUBB6 DYNC1I1 RAB3A DYNC1H1 TP53 DYNC1LI2 ATAT1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP2571%HOMO SAPIENS Polycystic kidney disease pathway MYC WNT16 SFRP4 PDE1A NRAS FLT1 MAP2K2;MAP2K1 PRKAA1 WNT6 WNT11 HRAS DVL1 DVL2 MAPK3 DVL3 KCNN4 WNT1 WNT2 WNT3 FZD1 JUN WNT10B BRAF WNT10A PRKAA2 FZD3 IGF1R FZD2 FZD5 RPS6KA1 KRAS WNT7B FZD7 FZD6 GNAS-1 ADCY6 EGF FZD9 FZD8 GNAI3 WNT7A IKBKB SSTR2 GNAI1 GNAI2 TSC1 FOS KDR PRKAB2 PRKAB1 GNAQ SLC12A2 WNT4 RHEB IGF1 GSK3B FZD4 PRKAG1 PRKAG2 CCND1 PRKAG3 CTNNB1 WNT9B WNT9A MTOR WNT8A WNT8B ERBB2 VEGFB WNT3A WNT5A TSC2 PLCG2 GNA11 WNT2B SRC FZD10 PKD2 PKD1 TNF WNT5B STK11 CFTR NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260410%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity ABCA1 RARA CYP2E1 ABCB1 RARG ABCD3 ABCB4 ABCB11 ABCC3 NR1H3 NR1I3 ABCC2 NR1I2 RARB PPARD PPARA CYP8B1 CYP26A1 PPARG CYP1A2 NR1H4 CYP27B1 VDR CYP24A1 CYP7A1 ABCD2 ABCG5 CYP4B1 ABCG1 CYP2B6 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260410%WP334%HOMO SAPIENS GPCRs class B secretin like PTH1R ADGRL1 ADGRL2 ADGRL3 ADCYAP1R1 CRHR1 GLP1R CALCRL GHRHR GIPR VIPR1 GCGR VIPR2 GLP2R SCTR PTH2R CRHR2 ADGRE1 ADGRG2 CALCR ADGRE5 ADGRL4 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260410%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CTCF CCR2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma MYC WNT16 SENP2 DKK1 DKK2 SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B ROR1 ROR2 CSNK2A1;CSNK2A3 CTBP2 CTBP1 NLK CXXC4 NKD1 NKD2 WNT6 WNT11 WIF1 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 FZD1 JUN WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 CCND3 FZD5 CSNK1A1 SOX7 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A FOSL1 TPTEP2-CSNK1E;CSNK1E NOTUM EZH2 KLF4 MTDH WNT4 GSK3B PORCN TCF7 LRP5 CCND1 LRP6 CTNNB1 WNT3A WNT5A AXIN1 LEF1 DKK4 ELAVL1 APC WNT2B CHD8 FZD10 FRAT2 CCND2 SOX17 PLAU SOST CER1 WNT5B RYK-1 SERPINF1 CSNK2A2 CTNNBIP1 KREMEN1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260410%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation COA3 GSTO1 AS3MT UQCRFS1 VDAC1 SDHA ATP1A1 CAT SOD1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260410%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis PTGS1 HTR1A FAAH KCNQ2 KCNQ3 CACNA1H TRPA1 TRPV1 PTGS2-2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260410%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits TCF7L2 VCAM1 PIK3CG EPAS1 TCF7L1 POSTN NOTCH1 TNC JAG1 LEF1 CYTIP CXCR4 TCF7 VHL SRC VEGFA WNT2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ANKRD39 LMAN2L NCAPH PARL CIAO1 FAM178B ITPRIPL1 TMEM127 COX11 CIAO2A CNNM3 CNNM4 MAPK1 FER1L5 STARD7 SEMA4C ANKRD23 ASTL MAPK3 NEURL3 DUSP2 KANSL3 PLXNB2 MMS19 SNRNP200 RHOA ERBB2 ZP2 COL2A1 ADRA2B CIAO2B GLUCURONIDATION%WIKIPATHWAYS_20260410%WP698%HOMO SAPIENS Glucuronidation UGT1A1;UGT1A6 PGM3 PGM2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PGM1 HK1 UGDH UGP2 PGM5 UGT2A1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260410%WP550%HOMO SAPIENS Biogenic amine synthesis ASMT GAD2 DBH CHAT PNMT TPH1 COMT GAD1 HDC ACHE AANAT DDC TH MAOA PAH PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260410%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGDR ANXA2 PTGDS HPGDS PPARGC1A PPARGC1B ABCC4 CYP11A1 EDNRA EDNRB PLA2G4A PPARG ANXA1 AKR1B1 PTGIS ANXA8;ANXA8L1 TBXA2R ANXA6 PTGFRN S100A10 PTGIR ANXA3 ANXA4 PRL ANXA5 SCGB1A1 S100A6 PTGFR MITF PTGES PTGS1 EDN1 TBXAS1 HSD11B1 HSD11B2 PTGER4 PTGS2-2 PTGER1 PTGER2 HPGD PTGER3 SOX9 CBR1-1 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260410%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling EFNA2 FGF14 FGF19 FGF13 FGFR4 FGF12 FGF11 FGFR1 BAD FGF10 LAMC3 LAMC2 LAMC1 NRAS SREBF1 MAP2K2;MAP2K1 PRKAA1 MAPK1 HRAS AKT1S1 MAPK3 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 IGF1R GRB2 ACACA KRAS SOS1 RAF1 PDPK1 PRL LAMB3 EGF LAMB2 LAMB1 RPS6KB2 IRS1 TEK PIK3CD IRS2 ITGAD RPTOR ITGAM GNG2 MLST8 JAK1 IFNAR2 RPS6 GNB1 CREB1 IFNAR1 PIK3R2 PIK3R1 EGFR EIF4EBP1 EIF4E EIF4B FGF21 HSP90AA1 LIPE MTOR PPP2R1A RPS6KB1 CDC37 PPP2R5D THBS2 COL1A1 COL3A1 COL5A1 COL2A1 FOXO3 PIK3R5 CASP9 GNG10 STK11 SPP1 DDIT4 GNG13 GNB2 GNB4 ATF4 GNB3 GNGT1 RAB10 INS;INS-IGF2 RAB8A FOXA1 NOS3 INSR GNG5 GNG4 GNG8 COL1A2 FGF9 RAB2A RELN CRTC2 TNC COMP GSK3B PDGFA TNN CREB3L1 TNR AKT3 FGFR2 PDGFRB VTN CHAD ITGA10 COL5A3 AKT2 ITGA11 COL5A2 ITGB5 ITGB8 PTEN ITGB7 ITGB6 PIK3CB PIK3C2A VWF PIK3CG COL6A2 ITGA8 PIK3C2B ITGA7 ITGA5 HGF CSF3R ITGA9 THBS4 THBS3 F2R MET TCL1B PPP2R1B PPP2R2A;PPP2R2D RAB14 CAB39L HIF3A STRADA PHLPP2 COL11A1 CHRM2 HSP90B1 COL11A2 PFKFB1 IBSP PFKFB4 PFKFB3 ITGAE ITGAL PPP2R5E PIK3CA HSP90AB1 ITGAX PPP2R5B PPP2R5A TBC1D1 EIF4E2 PPP2R3C PPP2R3A PIK3IP1 IL3RA PPP2R2C PPP2R2B IL2RG IL2RA IL2RB CDKN1A PPP2CB;PPP2CA EPAS1 LPAR1 LPAR2 LPAR3 FGF18 LPAR4 FGFR3 ATF2 LPAR5 LPAR6 IKBKB AKT1 IKBKG TSC1 FGF16 FOXO1-1 PFKFB2 MDM2-2 PDGFB PDGFD NOS2 PDGFC NGFR RHEB FN1 IL6R IL4R PIK3R4 TCL1A CSF3 PHLPP1 CSF1 EPO IL2 ITGB3 SLC2A4 ITGA2B PRLR IL7R FGF1 SLC2A2 FGF2 GYS2 FGF3 FGF4 TNXB FGF6 FGF7 FGF8 EPOR CREB3L3 CREB3L4 CREB3L2 PGF KITLG RAB11B CREB3 CSF1R CREB5 ITGB1 PPARGC1A FLT1 ITGB4 FLT4 ITGB2 ITGAV ITGA4 ITGA3 PPP2R5C ITGA2 NGF ITGA6 SLC2A1 PRKAA2 IFNB1-4 CHRM1 ANGPT4 ANGPT2 ANGPT1 EIF4E1B ATF6B GYS1 KDR ULK1 EPHA2 IGF1 PTK2 NOS1 GHR THBS1 KIT CAB39 IRS4 VEGFB VEGFC CDKN1B VEGFD JAK2 JAK3 PDGFRA TSC2 COL4A2 ELAVL1 COL4A1 COL4A4 OSMR COL4A6 EFNA5 HIF1A EFNA4 FGF20 OSM VEGFA FGF22 EFNA1 FGF17 EFNA3 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases CPS1 GLS2 AGXT2 CAD ALDH6A1 OTC RRM1 DPYS TYMS UPB1 TYMP DHODH NT5C NT5C3A RRM2B RRM2-1 DPYD TK2 UMPS ABAT INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260410%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy LRSAM1 HSPB8 LITAF SH3TC2 RAB25 MPZ SBF2 RAB4B GDAP1 DNM2 PMP22 RAB3A FGD4 MTMR2 RAB4A RAB3B KIF1B MFN2 RABAC1 RAB7A NDRG1 HSPB1 NEFL FIG4 RAB11A EGR2 RAB11B HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260410%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex GZMH;GZMB-1 DNMT3A SMAD4 TERF2 DNMT3B MCL1 SMARCA4 ETV6 CREBBP GABPA GABPB1 BCL2L1 EP300 FLT3 ZFX BCL2 FOXO3 DNMT1 PTEN ATM PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260410%WP3527%HOMO SAPIENS Pre implantation embryo DLX2 FOXQ1 MACROH2A2 NANOGNB MYBL1 CELF3 NR3C2 AQP9 POU5F1;POU5F1B DNMT3L NANOG;NANOGP8 KHSRP SIX3 FOXD1 SOX11 ZAR1 DPPA3 ZFP42 PADI6 BARX2 ZFP36L2 LEUTX TCF7L1 NLRP5 MTA3 DPRX-1 CDX2 IRX5 HNRNPAB TBX3 ESRRA MOS TPRX1;RAX2 ZSCAN4 MXD1 CDH1 BATF3 GATA3 NKX2-1 SOX8 DDIT3 KLF4 IRF4 ZFP36 PBX1 TEAD4 TFAP2E;TFAP2B SMARCA4 ATP1A1 E2F5 ELAVL1 GATA2 AQP3 EGR1 SOX2 FOSB COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260410%WP5145%HOMO SAPIENS COVID 19 structural coverage map MACROH2A1 UPF1 NRP1 MACROH2A2 SLC6A19 ISG15 UBB;UBC IGHMBP2 MRM2 MACROD1 ACE2 MACROD2 UBA52 CMTR1 PAIP1 APOA1 TAB1 UPF2 AQR MPP5 PARP14 PARP9 GDAP2 NLRP12 TOMM70 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260410%WP500%HOMO SAPIENS Glycogen synthesis and degradation PHKB PHKA1 PPP2R3B HK2 PPP2R3A PHKA2 PGM1 HKDC1 PPP2R2C AGL-1 HK1 PPP2R2B GSK3B PHKG2 PTPA PPP2R1A PPP2R5C GBE1 PPP2CB;PPP2CA PYGL PPP2R5D GYS2 GYG2 GYG1 GSK3A PPP2R1B PPP2R2A;PPP2R2D GYS1 CALM1 CALM3;CALM1 CALM2 HK3 PPP2R5E PYGB PYGM UGP2 PPP2R5B PHKG1 PPP2R5A SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260410%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 ACE2 FURIN KDR NRP1 VEGFA COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260410%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity PARD6B PLSCR1 COLEC11 C5 C6 C7 C9 C5AR1 FCN2;FCN1 MBP C3AR1 MASP2 C3-1 C8A PARD6A HTRA2 DIABLO-1 SCRIB C5AR2 C1QB ITGAM MPP5 C8B XIAP CR2 C2 C1QC PATJ CD55 C4BPA C4BPB CLU ATP11C ATP11A TYRO3 SERPING1 MASP1 CFB LLGL2 CFI CFP MARK3 MARK2 MARK1 ATP8B3 ITGB3 ATP8B1 CFH-3 CFD C8G DLGAP5 PLSCR3 MBL2-1 PLSCR4 GAS6 CRB2 COLEC12 CRB1 IFNG COLEC10 C1S C1R PARD6G SUSD4 CD59 CSMD1 DEDD CR1L;CR1 MERTK PARD3 PROS1 FASLG CASP9 CYCS-1 CASP7 CASP8 CASP10 AXL CASP3 APAF1 CX3CL1 ITGB2 FAS ITGAV CX3CR1 PRKCZ BAK1 BAX BID ATP8B2 TGFB2 CAP1 TGFB1 TGFB3 ATP10A VTN MFGE8 PRKCI LOC110384692;C4A;C4B_2;C4B ITGAX ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260410%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFB1 PDGFD SMAD2;SMAD3 AGTR1 IL11 RRAS MAPK1 F12 MAP2K6 MAS1 PTPN11 TGFBR1-1 SMAD4 COL1A1 AGT TGFBR2 RAF1 IL6ST SP1 HIF1A ACE2 IL11RA RACK1 JUND NOX4 ACTA2 CCN2 COL1A2 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260410%WP3594%HOMO SAPIENS Circadian rhythm genes CRY1 CLOCK NFIL3 NR1D1 PER1 CDK4 SREBF1 PRKAA1 NR1H3 PPARA JUN MAPK10 F7 DHX9 DBP RORA ID3 GNAQ CREB1 KCNMA1 AHR NRIP1 EP300 ARNT KLF9 MTTP HDAC3 UTS2R PRKDC PRKG2 RAI1 MAPK8 ATF4 NAGLU FAS ROCK2 ADCY1 HNF1B UBA52 NKX2-1 RPS27A PTGDS SIK1;SIK1B PPP1CA ADORA2A GSK3B PPP1CC SFPQ-1 CHRNB2 CRTC1 PRKCG DRD2 DRD3 DRD4 PTEN NTRK3 HNRNPU PPP1CB CCAR2 TPH2 MTA1 TPH1 ZFHX3 HDAC2 HDAC1 PML ARNTL SUV39H1 SIN3A SIX3 SKP1 PRF1 NCOR1 SLC6A4 TPTEP2-CSNK1E;CSNK1E EZH2 AVP ID2-1 PROKR2 SIRT1 NAMPT TP53 CREM CPT1A NOS2 ARNT2 OGT-1 IL6 NGFR NR1D2 PER2 DYRK1A CRY2 AANAT PHLPP1 MTNR1A TNFRSF11A CSNK1D RELB DDC TH TOP2A AHCY GNA11 PROK2 FBXW11 PROK1 METTL3 SOX14 CLDN4 ATF5 MAGED1 EGR3 NR2F6 SETX NMS ID4 HNRNPD FBXL3 SUV39H2 UBE3A KCND2 SFTPC PAX4 PROX1 MC3R CIPC ARNTL2 CUL1 PROKR1 GFPT1 HOMER1 CAVIN3 AGRP LGR4 KCNH7 USP2 CARTPT PSPC1 TIMELESS KMT2A OPN4 OPN3 NONO RBM4;RBM4B KDM5A HEBP1 PPARGC1A DDX5 KLF10 THRAP3 TOP1 OPRL1 CIART ATOH7 ADIPOQ NOCT CRX LEP PPARG BHLHE41 RORB PRKAA2 UBB;UBC BHLHE40 NTRK1 CHRM1 HTR7 NLGN1 SERPINE1 NPY2R NPAS2 BTRC NPS CST3 ADORA1 DRD1 BTBD9 PRMT5 HCRTR2 HCRTR1 MTNR1B MAGEL2 NCOA2 GHRH CRH GHRL ADA STAR TYMS MYBBP1A SLC9A3 HS3ST2 MAPK9 EGR1 JUND RORC OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP5094%HOMO SAPIENS Orexin receptor pathway CASP3 PLCD1 MAP2K2;MAP2K1 PRKAA1 MAPK1 SMAD1 DYNLT1 ADIPOQ NPFFR1 DAGLA MAPK3 NPY BMP7 SLC1A2 NPVF SMAD5 HCRT LEP CCK MAPK14 SLC2A1 PDK1 PRKCZ RPS6KA1 MAPK7 PDPK1 PLD1 GNAS-1 CXCL8 OPRK1 GNAI1 FOXO1-1 CGA FSHB CAMKK2 RPS6 GNAQ CREB1 HCRTR2 HCRTR1 IL6 LHB GHRL NFE2L2 PIK3R2 PIK3R1 IL10 STAR EIF4EBP1 ARRB1 ARRB2 EIF4B CXCL2;CXCL3;CXCL1-1 SLC2A4 IL4 BMPR1A GNRH1 STAT3 PTPN11 TH MTOR SGK1-1 RUNX2 RPS6KB1 IL1B PRKD1 PRKCB PRKCE PRKCD GNA11 PRKCA VHL IL9 RRAGC HIF1A MAPK9 POMC TNF GCG NOX4 CASP9 GRIA1 PDHB MAPK8 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome POLR2H POLR2L ANAPC1 ARF6 IL1A MAPK1 LGALS3 ZC3H8 ZC3H6 CHCHD5 ACOXL IL23A PSD4 ARL14 CKAP2L POLR1A POLR1B GRB2 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H IL36A FBLN7 IL36B TMEM87B SLC20A1 TULP1 IL36RN TTL IL1RL2 IL36G IL1F10 GATA3 RAC1 IL1RN IL1RAP IL37 IL1R1 IL6 PTK2 SOCS3 SOCS1 CSF2 CSF1 IL2 STAT1 GAS6 IL1B PLCG2 MERTK CXCL13 BCL2L11 POLR2E POLR2F PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260410%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway MYL2 KIF23 EZR RACGAP1 RAB35 SEPTIN2 RDX AFAP1 OCRL MSN ANLN RHOA POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260410%WP5485%HOMO SAPIENS Post COVID neuroinflammation CCL11 IFNG IL18 FURIN IL6 IL1B GFAP TLR8 TLR7 CXCL8 IL10 TMPRSS2 IL1A ACE2 MAPK1 IL2 IL4 TLR4 TNF HMGB1-1 TLR3 IL12A COPPER HOMEOSTASIS%WIKIPATHWAYS_20260410%WP3286%HOMO SAPIENS Copper homeostasis MTF1 STEAP2 CASP3 SLC11A2 GSK3B CCND1 COX11 BACE1 ADAM10 CCS ADAM17 PTEN PRNP JUN MTF2 APP MAPT MT2A APC SOD1 SLC31A1 SP1 AKT1 FOXO1-1 STEAP4 COMMD1 COX17 ATP7B SOD3 FOXO3 ATP7A TP53 SLC31A2 ATOX1 PIK3CA STEAP3 MDM2-2 SCO1 ADAM9 XIAP MT3 STEAP1 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260410%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IL1A TRAF6 NFKB1 TIFA PRKCZ SQSTM1 IRAK1 UBE2N AJUBA UBE2V1 PURINE METABOLISM%WIKIPATHWAYS_20260410%WP4792%HOMO SAPIENS Purine metabolism AMPD1 APRT DGUOK ITPA PRPS1 ADA PNP-1 ATIC HPRT1 XDH ADSL IMPDH1 ADSS2 POLYOL PATHWAY%WIKIPATHWAYS_20260410%WP690%HOMO SAPIENS Polyol pathway AKR1B1 SORD ALDOB KHK INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP453%HOMO SAPIENS Inflammatory response pathway ZAP70 LCK FN1 IL4R LAMC2 LAMC1 IL2RG THBS1 VTN IL2 IL2RA IL4 IL2RB LAMA5 IFNG COL1A1 COL3A1 IL5RA CD40LG THBS3 LAMB2 LAMB1 TNFRSF1A CD86 CD40 TNFRSF1B CD80 IL5 CD28 COL1A2 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260410%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment MYC IQGAP3 PARD6B BAD GAB1 YWHAB NRAS MAP2K2;MAP2K1 MAPK1 MAP2K7 HRAS MAPK3 MAP2K4 PARD6A MAP3K3 JUN TP73 YWHAE MAP3K1 TCF7L2 TCF7L1 GRB2 MAPK7 KRAS SOS1 MKNK1 RAF1 PDPK1 YWHAH RPS6KB2 IRS1 IKBKB AKT1 PIK3CD IRS2 IKBKG YWHAZ MAP3K5 RAP1B RAC1 TP53 CREB1 NGFR RAPGEF1 CRK CFL2 RTN4R EIF4EBP1 EIF4E STAT3 PTPN11 MTOR RPS6KB1 LEF1 YWHAG TIAM2 TIAM1 PARD3 KIDINS220 FOXO3 CASP9 CYCS-1 ARHGDIA PAK1 MAPK8 CASP8 EEF2K MAP2K5 FADD BDNF TRADD APAF1 WASL DOCK7 LIMK1 MAPKAPK2 BCL2 BMP7 RHOA ROCK2 ROCK1 PRKCZ CDC42 CHUK NTRK2 BAX DIAPH1 NFKBIA TRAF6 YWHAQ NPTX2 SORT1 ARHGAP35 RND3 SMPD1 GSK3B TCF7 MAPK11 CTNNB1 PRKCG FRS2 PIK3CB EEF2 PIK3CG PRKCH PRKCB PRKCE PRKCD PRKCA STMN1 LINGO1 CFL1 PLCG1 PRKCI BCL2L11 SH2B2 SHC1-1 PIK3CA MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260410%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TGFB1 ERBB4 MYC TERT ITGA6 SFRP1 NRG3 CCND1 CLDN4 ITGB1 ALPL AKT1 CDH1 TNF ZEB2 RETT SYNDROME%WIKIPATHWAYS_20260410%WP4312%HOMO SAPIENS Rett syndrome CRK SHANK3 GABRA3 KDM5B TRRAP HDAC1 SATB2 HTT GPS2 CHD4 HDAC8 RHOBTB2 CECR2 TAF1B HIVEP2 SCN1A EIF2B2 KCNJ10 SMARCA1 XAB2 CDKL5 TBL1XR1 NCOR2 IMPDH2 HAP1 SRRM3 SCN8A SCN2A BRAF SMC1A ACTL6B NCOR1 GRIN2B SMARCA4 FOXG1 MECP2 TCF4 SMARCA2 SYNE2 MEF2C HDAC5 GRIN2A STXBP1 GABBR2 SYNGAP1 GNAO1 GABRD GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260410%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis PHF19 TRAF1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IRF5 IL6ST CIITA BLK STAT4 CTLA4 IL2RA CCR6 CD40 ITGAV FCRL3 PTPN22 PADI4 SLC22A4 CD244 MALE INFERTILITY%WIKIPATHWAYS_20260410%WP4673%HOMO SAPIENS Male infertility PIWIL3 SPO11 ETV5 YBX2 HORMAD2 HORMAD1 CLOCK MSMB PACRG SEPTIN12 TEX15 FOLH1B;FOLH1 USP26;USP29 CXXC1 DDX20 ABLIM1 OR2W3 PMS2 LRWD1 CDC42BPA REC8 MLH3 MTR-1 CTCFL ARNTL ERCC1 ERCC2 BRDT PEX10 GPX1 H4C1 CHD2 BRCA2 MTHFR CAT SOD3 MDM2-2 GNAO1 NOS2 MLH1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 HLA-DRA CLU NFE2L2 CREBBP AHR ABCB1 PON2 XRCC4 PON1 XRCC5 LIG4 EP300 ESR2 ESR1 AGO2 CYP26B1 CCNA1 CYP1A1 AHRR BHMT SLC46A1 CDK9 MTHFD1 FASLG TNF PEMT KDM3A POLB TRIP13 PARP1 BCL2 POLG FAS SHMT1 MMP2 MMP9 RFC1 UBE2B NOS3 INSR CYP17A1 APOB PRMT6 PSAT1 MTRR LTF NOS1 TCN2 KLK3;KLK2 THBS1 AR SOX5 ATM SIRPA;SIRPB1;SIRPG CCNK IHO1 CCNT1 UBR2-2 SLC16A7 RGS9 RAG1 NANOS1 PRDM7;PRDM9 PRM3 SPATA17 XPC MSH4 MSH5 TSSK6 TSSK4 DDX4 STRA8 USP8 UBD DND1 MOV10L1 TMEM132E XRCC2 XRCC3 SRD5A2 PUM2 DAZL CCNT2-1 PIWIL2 CRISP2 EPPIN;EPPIN-WFDC6 PIWIL1 PIWIL4 NQO1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260410%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 ANO6 IL17RC IL17RA IL17A ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260410%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects PPP3CA BAD HSD17B10 ARAF RB1CC1 NRAS MAP2K2;MAP2K1 MAPK1 MAP2K7 HRAS MAPK3 NRBF2 ATG2B IDE ADAM10 TUBA1C MME PSMA8 BRAF TUBB4B TUBB1 CAPN1 TUBA4A MAPK10 PLCB3 RTN3 PSMD14 CACNA1D CACNA1C KRAS KLC1 RAF1 KLC4 KLC3 KLC2 TUBA3E;TUBA3C-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 IRS1 ATP2A3 PIK3CD TUBB2B;TUBB2A IRS2 SLC25A6 TUBAL3 BECN2 ADRM1 SLC25A31 CYBB GNAQ PIK3C3 PIK3R2 PSENEN PIK3R1 LPL PSEN1 APH1A NCSTN APH1B BACE1 ATG101 MTOR WIPI2 TNF PIK3R3 NOX4 GRIN2A ERN1 CALM3;CALM1 CALM2 RYR3 CASP9 CYCS-1 CASP7 MAPK8 CASP8 CASP3 FADD ATF4 APAF1 APBB1 IL1A INS;INS-IGF2 FAS SEM1 APP EIF2AK3 GRIN2C AGER GRIN2B GRIN2D INSR ATF6 SNCA PPID NFKB1 TNFRSF1A BID VDAC2-1 WNT4 VDAC3 GRIN1 GSK3B CAPN2 AKT3 CTNNB1 ATP2A1 AKT2 ADAM17 SLC25A5 CACNA1F PIK3CB CACNA1S EIF2S1 WNT3A WNT5A ITPR1 AXIN1 MAPT DKK4 APC WNT2B FZD10 CDK5R1 FRAT2 CALM1 APC2 WNT5B PLCB4 PIK3CA CSNK2A2 PLCB1 AXIN2 WNT16 PLCB2 DKK1 DKK2 SFRP4 CSNK2B GAPDH-1 CSNK2A1;CSNK2A3 WNT6 WNT11 CALML6 DVL1 CALML3 DVL2 CALML4 DVL3 WNT1 WNT2 WNT3 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 CSNK1A1 WNT7B FZD7 CDK5 FZD6 FZD9 FZD8 WNT7A IKBKB AKT1 GPR83 MAP3K5 TPTEP2-CSNK1E;CSNK1E SLC25A4 WIPI1 CHRNA7;CHRFAM7A ATG13 PTGS2-2 ATG2A DDIT3 NOS2 IL6 NOX1 NAE1 AMBRA1 ATG14 PIK3R4 LRP5 LRP6 EIF2AK2 TUBB3;TUBB6 CSF1 IL1B PSMD8 ITPR3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 PSMC2-1 PPIF PSMA5 MCU PSMA6 PSMA3 PSMA4 PSMA1 PSMD12 RTN4 PPP3CB PPP3CC PSMD13 PSMA7 PSMB6 PSMB7 TRAF2 PSMB4 PSMB5 PSMB2 BECN1 PSMB3 PSMB1 PSMA2-1 CHUK PSMC5 PSMC6 PSMC3 PSMC4 ATP2A2 PSMC1 ITPR2 TUBA1A LRP1 APOE ULK2 ULK1 PPP3R1 NOS1 VDAC1 PSEN2 KIF5C IRS4 KIF5B KIF5A XBP1 RELA MAPK9 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260410%WP259%HOMO SAPIENS Nifedipine activity MAP2K2;MAP2K1 PCNA MAPK1 PTK2B KDR BDKRB2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SOD1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome FGFR1 PLK1 FGF10 COMT SREBF1 TXNRD2 ARNTL FOXC2 MED15 SHH SREBF2 CDH15 GSC2 GBX2 NCOR1 H4C1 RAF1 CRKL XPO1 SNAP29 TSKS EMC10 ZDHHC8 ZNF274;ZNF74 CLTCL1 RCC1 TP53 PITX2 TANGO2 CUL3 C22orf39 CLDN3 THAP7 TSSK2 KPNB1 ASF1A RTL10 NPRL2 NPRL3 TRMT2A ESS2 CBX5 KLHL22 MALT1 GP5 LZTR1 CLDN5 LRRC74B NKX2-5 AIFM3 EGFR MRPL40 UFD1 PRKN MAG TNPO1 RTN4R DGCR8 SCARF2 DGCR2 DROSHA SEPTIN11-1 GP1BB GP1BA RAN SLC2A4 RANGAP1 SLC7A4 ALDH1A2 GNB1L DEPDC5 CCDC188 FOXC1 CYP26A1 ARVCF LOC102724770;DGCR6;DGCR6L TBX1 CYP26B1 RANBP1 SERPIND1 SEPTIN5 SEPTIN8 P2RX6 ACTC1;ACTG2 HES1 FGF8 HDAC3 HIRA HIRIP3 GP9 ACTA2 GLUD1;GLUD2 ALDH4A1 OAT PRODH;LOC102724788 RTN4 CDC45 BCL2 CDC42 CHRD SLC25A1 HAND2 RELN FGFR2 SHOC2 DRD2 PAX3 PAK4 CLDN1 VWF RBX1 PPP1CB FOXA2 SRF POLR2A RORC PI4KA MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260410%WP2857%HOMO SAPIENS Mesodermal commitment pathway AXIN2 SMAD2;SMAD3 DKK1 PRKAR1A FGFR1 BMPR2 CTBP2 HES7 KDM6A NLK TBX6 LATS1 FOXC2 NANOG;NANOGP8 GRHL2 WNT3 ARID5B PPP2CB;PPP2CA TCF7L1 BMP4 ACACA FZD5 BCORL1 SNAI1 TBX3 FZD8 PRKACA-1 GATA3 PITX2 KLF4 KLF5 PIAS1 SMAD6 NFE2L2 SETD2 TEAD1 TEAD2 EOMES TOX HMGA2 FOXC1 TBX1 PBX3 ACVR1 ADAM19 TWSG1 DLL1 MACF1 LEF1 INHBA CCDC88A CSRP2 HNF4A MSGN1 FGF8 PAX6 ARL4A HAND1 IQCJ-SCHIP1;SCHIP1 WDCP ACVR2B ACVR2A ZIC2 MEIS1 SESN1 TRIM28 TET1 DNMT3B C9orf72 SMAD1 POU5F1;POU5F1B BMP7 VAV3 RPL38 FOXA1 SOX21 CEP250 DIP2A BHLHE40 YAP1-1 CHRD WDHD1 ZNF281 FOXH1 EMSY WDFY2 HPRT1 GATA6 MBTD1 EPB41L5 UBR5 NOG ATP8B2 GDF3 ZFHX4 TRERF1 AMH NABP2 DDAH1 FZD4 PLCH1 PBX1 NODAL TRIM71 CCND1 RARG HTT NCAPG2 PHF6 TRIM5 ZIC3 BMPR1A C1QBP CRTC1 JARID2 RARB SLC2A12 PARP8 TOX3 AEBP2 MTF2 SMAD4 AHDC1 WNT3A JAK2 AXIN1 ASCC3 CCDC6 ZNF462 TCF4 ELK4 EXT1 ELP4 EXT2 RGS10 MIXL1 FOXA2 SOX17 CUL4B LEFTY2;LEFTY1 SOX2 SRF CILIOPATHIES%WIKIPATHWAYS_20260410%WP4803%HOMO SAPIENS Ciliopathies TTBK2 CPLANE1 TMEM231 TMEM17 CEP83 C2CD3 KIF7 TCTN3 GLI3 TCTN2 TCTN1 GLI2 CC2D2A SMO KIAA0753 OFD1-1 B9D1 NPHP1 PIK3R4 DYNC2I2 INVS DYNC2I1 PLK4 TRAF3IP1 IFT172 CEP164 PKD2 PKD1 IFT52 FLCN ZIC2 ODAD1 TMEM107 GALNT11 CNGA1 ODAD3 NEK1 ODAD2 BBS9 ODAD4 BBS7 MCIDAS IFT57 TBC1D32 BBS5 CSPP1 DRC1 CEP290 NEK2 DNAAF3 BBS4 DYNC2H1 DNAAF2 DNAAF1 IQCB1 DNAJB13 MKKS DNAAF6 IFT140 IFT80 DNAAF5 DNAAF4 CFAP410 RP1-2 WDR35 LZTFL1 FAM161A TMEM138 BBS10 CFAP298;CFAP298-TCP10L IFT43 CCNQ EVC CCNO BBS12 GAS8 INTU AK7 RP2 IFT81 GLIS2 MAK CEP78 NEK9 TMEM216 GPR161 ZNF423 DNAH11 AHI1 EFHC1 WDPCP ARL2BP TMEM237 UNC119 CILK1 DNAL1 CNGB1 CEP104 HYDIN ARL6 TAPT1 ARL3 CCDC39 DNAI2 DYNLT2B DDX59 CRX CCDC65 CFAP52 PKD1L1 DYNC2LI1 POMGNT1 PKHD1 TOPORS NME7 NME9 ARL13B ZMYND10 TMEM67 TTC21B KIZ CFAP53 RAB23 KATNIP PDE6D NPHP3 CCDC103 BBS2 DNAH6 NEK8 RSPH9 POC1A EVC2 BBS1 POC1B RAB28 USP9X DNAI1 WDR19 ADCY6 TUB PCARE RSPH4A SCLT1 LCA5 RSPH3 IFT122 RPGRIP1 DCDC2 RP1L1 TULP1 CENPF BBIP1 TTLL5 C8orf37 RSPH1 TTC8 KIAA0586 MKS1 ALMS1 IFT27 SPAG1 HYLS1 CEP41 B9D2 TRIM32 ATXN10 CLUAP1 ANKS6 SPATA7 CCDC40 INPP5E CEP19 CEP120 XPNPEP3 OCRL RPGRIP1L PIBF1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260410%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GOT2-1 SLC25A22 GLUD1;GLUD2 SLC25A12 SLC25A13 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260410%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways DNMT3A CHDH DNMT3B ALDH7A1 AGXT2 MAT2A MAT1A MTHFD2 MAT2B DNM1 AMT PSPH MTR-1 CBS;CBSL SHMT2 DNMT3L SHMT1 GPX1 GPX4 GPX6 PLD1 SOD1 GAD1 AHCYL2 GSR MTHFR PHGDH SOD3 DMGDH AHCYL1 CTH SLC25A48 GPX5 GPX7 BCAT1 BCAT2 BHMT2 MTHFD1L SARDH PSAT1 TYMS CEPT1 DHFR2;DHFR BAAT GCLC GSS GAD2 BHMT AHCY CDO1 CSAD GNMT PCYT1B GCLM PCYT1A MTHFD1 MTHFD2L CHKB PCYT2 CHKA ETNK2 ETNK1 PEMT CHPT1 MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CASP8 MYC CHEK2 CASP3 E2F1 CDC25C CDC25A FANCD2 APAF1 CDK4 CDK1 PML RAD51 TLK1 FAS CHEK1 CDKN1A RPA2 RAD1 RFC1 RAD52 ATRIP RAD17 ATR RAD9A CCND3 CDK5 GADD45B GADD45A GADD45G BAX CDK6 CCNE1 BID TP53 MDM2-2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HUS1B CREB1 TLK2 CCNB3 CDK2 CCNE2 CCND1 PMAIP1 RRM2B DDB2 RAD50 MRE11 ATM NBN BRCA1 PIDD1 CCNB1 SMC1A CDKN1B SFN CCNB2 CCNG1 RB1 CCND2 PRKDC ABL1 CASP9 CYCS-1 SESN1 BBC3 PI3K AKT SIGNALING%WIKIPATHWAYS_20260410%WP4172%HOMO SAPIENS PI3K Akt signaling MYC EFNA2 FGF14 FGF19 FGF13 FGFR4 FGF12 FGF11 FGFR1 BAD FGF10 LAMC3 LAMC2 LAMC1 CDK4 NRAS MAP2K2;MAP2K1 PRKAA1 MAPK1 COL6A3 HRAS MAPK3 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 IGF1R GRB2 CCND3 KRAS SOS1 RAF1 PDPK1 PRL LAMB3 SOS2 EGF RBL2 LAMB2 LAMB1 RPS6KB2 IRS1 TEK PIK3CD TLR2 RPTOR GNG2 MLST8 RAC1 JAK1 PIK3R6 IFNAR2 SYK RPS6 GNB1 CREB1 IFNAR1 PIK3R2 PIK3R1 EGFR EIF4EBP1 EIF4E EIF4B FGF21 HSP90AA1 MTOR PPP2R1A RPS6KB1 CDC37 PPP2R5D THBS2 COL1A1 COL2A1 FASLG PIK3R3 FOXO3 PIK3R5 CASP9 GNG10 STK11 SPP1 DDIT4 GNG13 GNB2 GNB4 ATF4 GNB3 GNB5 GNGT1 BCL2 INS;INS-IGF2 NOS3 INSR GNG5 GNG4 BCL2L1 GNG8 NFKB1 COL1A2 FGF9 RELN COL9A1 TNC COL9A3 COL9A2 PKN3 PKN1 COMP GSK3B COL6A1 PDGFA TNN COL6A6 CCND1 COL6A5 CREB3L1 TNR AKT3 FGFR2 PDGFRB VTN CHAD ITGA10 AKT2 ITGA11 ITGB5 ITGB8 PTEN ITGB7 TGFA ITGB6 PIK3CB VWF PIK3CG COL6A2 ITGA8 ITGA7 ITGA5 HGF CSF3R ITGA9 THBS4 THBS3 F2R MET TCL1B PPP2R1B PPP2R2A;PPP2R2D CCND2 PCK1 PHLPP2 CHRM2 HSP90B1 BCL2L11 IBSP PPP2R5E PIK3CA HSP90AB1 PPP2R5B PPP2R5A EIF4E2 PPP2R3C PPP2R3A IL3RA PPP2R2C PPP2R2B IL2RG G6PC1 IL2RA IL2RB PKN2 CDKN1A PPP2CB;PPP2CA LPAR1 LPAR2 LPAR3 FGF18 LPAR4 PCK2 FGFR3 ATF2 G6PC2 G6PC3 LPAR5 THEM4 LPAR6 IKBKB AKT1 IKBKG CDK6 TSC1 CCNE1 TP53 MDM2-2 PDGFB PDGFD PPP2R3B PDGFC IL6 NGFR RHEB FN1 CDK2 IL6R IL4R CD19 CCNE2 TCL1A CSF3 PIK3AP1 PHLPP1 CSF1 EPO IL2 IL4 ITGB3 ITGA2B PRLR IL7 IL7R NTF4 MYB NTF3 FGF1 FGF2 GYS2 FGF3 FGF4 TNXB FGF5 FGF6 FGF7 FGF8 LAMB4 EPOR CREB3L3 CREB3L4 CREB3L2 PGF IL3 KITLG CREB3 CSF1R CREB5 MCL1 BDNF ITGB1 FLT1 ITGB4 FLT3 FLT4 ITGAV ITGA4 ITGA3 PPP2R5C ITGA2 ITGA1 NGF ITGA6 PRKAA2 IFNB1-4 CHUK NTRK1 CHRM1 NTRK2 ANGPT4 ANGPT2 ANGPT1 EIF4E1B ATF6B GYS1 TLR4 KDR FLT3LG EPHA2 IGF2 IGF1 PTK2 GHR THBS1 KIT SGK1-1 BRCA1 VEGFB VEGFC CDKN1B VEGFD JAK2 JAK3 PDGFRA TSC2 COL4A2 PRKCA COL4A1 COL4A4 OSMR COL4A3 COL4A6 COL4A5 EFNA5 EFNA4 RELA SGK3;C8orf44-SGK3 FGF20 OSM VEGFA FGF23 FGF22 EFNA1 FGF17 EFNA3 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260410%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis TAP1 MX1-1 PIAS1 IFNG JAK2 PTPN2 IRF9 IFIT1 PSMB8 IFNAR1 OAS1 IFI35 IFIT3 SOCS1 IFNGR1 IFNGR2 STAT1 IRF1 STAT2 JAK1 IFNAR2 IFITM3;IFITM2;IFITM1 TYK2 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome MYC GAPDH-1 HDAC2 PCNA MAPK3 WNT2 SNAP25 ABHD11 EIF2A ACACB ACACA GRB2 FZD9 VAMP2 CLASP1 CLDN3 GTF2I PKLR LAT2 BTK PRKG1 CLDN5 SQSTM1 DLST OGDH UBIAD1 HDAC3 CLDN4 DLD RB1 ATPAF2-2 HSPA2 CDKN1C CLTC ATF4 HOXC8 LIMK1 FAS RFC5 RFC2 BECN1 EIF2AK3 FBN1 NUP62 BAZ1B ULK1 DDX21 SF3B1 SMARCA5 DEK CTNNB1 UBE2L6 UBE2E3 MYO1C UBE2E1 MYBBP1A CLIP2 DNAJC30 STX1A ERCC6 FKBP6 VPS28 GRIP1 TSG101 ATP5MC2 ATP5MC3 FBLN2 FBLN5 ATP5MC1 TBL2 GTF2IRD1 CLDN1 CHTF18 BCL7B BUD23 VPS9D1 VPS37C VPS37D NRG1 VPS37A VPS37B METTL27 ATPAF1 HDAC6 ATP5F1A ATP5F1B CFL1 MVB12A EIF4H CLASP2 BRD4 ATP5PB TRIM74;TRIM73;TRIM50 TMEM270 ATP5F1D USF1 ATP5PO FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2879%HOMO SAPIENS Farnesoid X receptor pathway RXRA NR1H4 SLC27A5 FGF19 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 NR0B2 CYP7A1 ABCB4 ABCB11 FKBP5 IRS2 PPARGC1A SLC10A1 SLCO2B1 SULT2A1-4 IP6K3 BAAT CYP8B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma IL6 JAK2 ZEB1 JAK3 IL11 IL6R IL6ST RELA NFKB1 IL11RA STAT3 SOX4 JAK1 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260410%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium MYC ERBB4 NUMB BDNF CXCL12 NEUROD1 IL17A MAP2 KDM1A RTN4 NGF APP AGRN MECP2 CDK5 NTRK1 PAFAH1B1 NTRK2 ID2-1 ASCL1 ID1 RELN DISC1 DAB1 NGFR JAG1 GHRL RET GSK3B HEY1 PSEN1 SEMA4A NUMBL RTN4R VLDLR MARK2 STAT3 MRE11 NRG1 NOTCH1 DLL1 MAPT TCF4 HES1 PAX6 NTRK3 CDK5R1 MEF2C PLXND1 SOX2 NDEL1 MAP1B FAIM LRP8 NEURL1 NEUROG3 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260410%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PGS1 GPAT4 GPAM GPAT2 CRLS1 PI4K2A CDS2 PLA2G2A-1 GPAT3 GK GNPAT AGPS MOGAT3 CEPT1 CDIPT LPIN1 LPIN2 PIK3CB PIK3CG PTPMT1 PIP5K1A GPD1 PIK3CD CHKB PCYT2 PTDSS1 IPMK PEMT CHPT1 PIK3CA PEPTIDE GPCRS%WIKIPATHWAYS_20260410%WP24%HOMO SAPIENS Peptide GPCRs FPR2 CCR10 CCR1 ATP8A1 NPY4R2;NPY4R BRS3 MC4R CCKAR GHSR LHCGR NPY5R AVPR1B NPY1R TACR2 OPRM1 GRPR AVPR1A SSTR3 SSTR4 CCR9 TRHR C5AR1 OPRL1 CCR8 SSTR5 C3AR1 CCR7 OPRD1 CCR6 FPR1 CCR4 MC2R CCR3 GALR3 CCR2 GALR2 EDNRA GNRHR GALR1 EDNRB TAC4 NTSR2 NMBR MC1R CX3CR1 MC5R CXCR5 CXCR6 TACR1 SSTR1 SSTR2 CXCR3 OPRK1 CXCR2 OXTR NPY2R NTSR1 TACR3 TSHR AGTR2 ACKR1 HCRTR2 AGTR1 HCRTR1 CCR5 BDKRB2 BDKRB1 FSHR CXCR4 CCKBR CXCR1 AVPR2 MC3R TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260410%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc FH ACO1 IDH1 DLST SDHA ACLY PC CS OGDH SUCLG2 DLD IDH3A PDHA1 PCK1 MDH1 DLAT RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260410%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CD AKT1 FPR2 PIK3CG CMKLR1 LTB4R PDK1 MTOR GRK1 PIK3CA PIK3CB EPHB2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260410%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ALDH1A1 CYP2E1 CREB1 MTR-1 ADH5 CBS;CBSL MTHFR CEBPB ALDH1L1 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260410%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD IKBKG RELA NFKB1 AGER CHUK HMGB1-1 THBD NFKBIA IKBKB CCL18 SIGNALING%WIKIPATHWAYS_20260410%WP5097%HOMO SAPIENS CCL18 signaling CDH2 AK4-1 PTK2B CCR8 ZEB2 MMP2 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260410%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 IL5 SIGNALING%WIKIPATHWAYS_20260410%WP127%HOMO SAPIENS IL5 signaling LYN BTK GSK3B PIK3R2 PIK3R1 CSF2RB ELK1 MAP2K2;MAP2K1 MAPK1 STAT5A IL2 STAT1 STAT3 MAPK3 PTPN11 RPS6KB1 JUN PIK3CG JAK2 SPRED1 GRB2 RPS6KA1 KRAS MAPT SOS1 IL5RA RAF1 GSK3A RPS6KB2 AKT1 STAT5B JAK1 FOXO3 SHC1-1 SYK RPS6 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260410%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism POR H6PD CYB5A STAR HSD3B1;HSD3B2 HSD17B3 HSD11B1 CYP11A1 HSD11B2 SRD5A2 CYP17A1 CYP11B1;CYP11B2 CYP21A2 CYP19A1 NAD METABOLISM%WIKIPATHWAYS_20260410%WP3644%HOMO SAPIENS NAD metabolism SIRT3 NMNAT1 NRK NMNAT3 NMNAT2 PARP1 NADK SIRT6 CD38 SIRT1 NT5E NAMPT SIRT4 SIRT5 SIRT2 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260410%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells TGFB1 VCAM1 TGFB3 IL1B CCL5 CD40LG TLR7 PF4;PF4V1-1 ICAM1 TLR2 TLR4 SELP CD40 SELE CCL13;CCL2 TGFB2 SELPLG GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260410%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease GTF2I CYBA DGUOK BTK TLR9 TLR8 MAPK1 NCF1 MAPK3 ESR1 RBPJ NOTCH1 CDC42 DLL4 DOCK6 CYBC1 COX4I2 CXXC5 CHCHD2 KCNN3 SP1 C4orf54 BEND6 NOTCH4 EFL1 SHCBP1 NFKB1 ARHGAP31 NOX3 NCF2 IBTK EIF6 NCF4 EOGT RAC1 SBDS CYBB T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260410%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CD3E CD3D CD4 GRAP2 CD247 IL17A MAP2K2;MAP2K1 LCP2 ICOS MAPK1 HRAS MAPK3 PPP3CC CDKN1A IL12B IL12A JUN IL23A GRB2 SOS1 PDPK1 RAF1 IFNB1-4 CHUK NFATC1 BAX IKBKB NFKBIA PIK3CD AKT1 IKBKG BCL2L1 CTLA4 TSC1 NFKB1 RPTOR CCL19 FOS MLST8 MYD88 IRF2BPL IFNAR2 LTA TP53 CD28 CCL28 TYK2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 LAT LCK CARD11 RHEB HLA-DRA IFNAR1 BCL10 MALT1 GSK3B PIK3R1 CCND1 RASGRP1 STAT4 FYN IL2 IL4 IL18R1 MTOR PTPRC PTEN PRKCQ IL12RB1 CDKN2A IFNG IL12RB2 JAK2 ITPR1 TSC2 DEPTOR PLCG1 RELA RICTOR TNF CD86 CD80 FOXO3 IL23R CD3G FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260410%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 LDLR CETP APOA4 LCAT LPL LIPC PLTP APOC2 APOA2 APOA1 APOA5 LRP1 SEL1L LMF1 GPIHBP1 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260410%WP2006%HOMO SAPIENS miR targeted genes in squamous cell VCAM1 ACAA2 AP2A1 MOV10 NRP1 LAMC1 E2F3 PXDN PPP1R7 TXNRD1 TMEM59 LAMTOR5 NEDD4 ATRX POGLUT3 RARS1 ELOVL5 SRSF9 SLC4A10 NCL-1 P4HA2 GNAI2 SYNE2 SIGMAR1 MTPN SEC23A HOXA7 HSD17B12 SH3BP4 HMOX1 SLC12A2 PEDS1-UBE2V1;PEDS1 RHEB BET1 CPNE8 VEZT SRPRB-1 PWP1 DHX57 ARFIP1 CIAO2A DHX40 UBE2J1 COMMD9 ATP6V1C1 PDCD4 FGF2 ANP32B ADAR MAGT1 FBXW11 HES1 TMED7 TPM3 CSDE1 PTMA MRPS33 TPM1 AKAP8 MPZL1 ARF4-1 ANPEP SPCS3 GFPT1 MAP3K8 AXL GOLGA7-1 PISD RAB34 RAI14 NF2 SDCBP GAS2L1 CHMP2A PICALM SLC38A1 TMED10 ADIPOR2 SMAD1 POLD2 RTN4 TMED2-1 MRPL20 CTDSP1 SLC38A2 ATP6V1F PKM PDLIM7 GALNT7 IDH1 TBCA TRAM1 HNRNPM ATP2A2 MRC2 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 SH3BGRL3 ANXA2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRPF40A POM121;POM121C PNP-1 THBS1 DNAJB1 POLR2C CBFB GALNT1 AP3D1 ARCN1 ATP6V0E2;ATP6V0E1 FMNL2 TGFBR2 MET PODXL CUL4B FNDC3B FNDC3A TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders FAH TAT HPD GSTZ1 HGD ERBB SIGNALING%WIKIPATHWAYS_20260410%WP673%HOMO SAPIENS ErbB signaling MYC ERBB4 PAK2 NCK2 BAD NCK1 GAB1 ARAF ELK1 NRAS MAP2K2;MAP2K1 MAPK1 MAP2K7 HRAS MAPK3 CDKN1A MAP2K4 JUN BRAF MAPK10 GRB2 KRAS SOS1 PDPK1 RAF1 SOS2 EGF RPS6KB2 PIK3CD AKT1 CRKL FOXO1-1 TP53 BTC MDM2-2 NRG2 EREG NRG4 ABL2 CRK PTK2 NRG3 GSK3B PIK3R2 PIK3R1 CBL AREG CCND1 EGFR AKT3 EIF4EBP1 STAT5A AKT2 PRKCG HBEGF PAK3 MTOR PAK5 RPS6KB1 PAK4 TGFA PIK3CB ERBB2 CAMK2B CDKN1B CAMK2D BUB1B-PAK6;PAK6 NRG1 CAMK2A CBLB PRKCB PLCG2 PRKCA CAMK2G SRC MAPK9 SHC4 SHC2 BCL2L11 SHC3 STAT5B PIK3R3 ABL1 ERBB3 SHC1-1 PIK3CA PAK1 MAPK8 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5402%HOMO SAPIENS 10q22q23 copy number variation ERBB4 DNAJB13 GLUD1;GLUD2 CEBPA MAT1A AFG3L2 OPN4 MAS1 ADAM10 PPARG GRID1 RSPH9 BMP2 RSPH4A RSPH3 RSPH1 NFKB1 SH2D4B BUB1B ADIRF LDB3 NRG3 GHITM IQUB ROPN1L FAM25A;FAM25C;FAM25G;FAM25E-1 RSPH6A NME5 CDHR1 MMRN2 DYDC2 DYDC1 ZMYND11 RGR SF3B4 BMPR1A PDS5B PDS5A SNCG C10orf99 GPR15 RAD21 SUSD2 WAPL STAG1 TSPAN14 SMC3 LRIT2 SMC1A SHLD3 SH3GL3 LRIT1 PRXL2A SHLD2 SHLD1 CCSER2 MAD2L2 ACTN2 TNFSF11 VEGFA SIRT4 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260410%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCD3 PLCD4 PLCB2 PLCD1 SBF2 PLCH2 PLCB3 PIK3CD PIK3C3 PIK3R4 PLCH1 MTMR1 MTMR2 MTMR8 PTEN PIK3C2G PIK3CB PIK3C2A PIK3CG MTMR6 PIK3C2B MTM1 PIP4P2 PIP4P1 MTMR10 INPP5D MTMR12 MTMR11 PLCG2 PLCZ1 PIP5K1A PLCE1 SBF1 MTMR3 PIP4K2A MTMR9 PIP4K2B MTMR4 MTMR7 PIP5K1B PIP5K1C PLCG1 PIP4K2C SACM1L OCRL PIKFYVE PLCB4 PIK3CA PLCB1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260410%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling GRK6 MAPK14 CREB1 RHEB H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TSC2 RAF1 PRKCA RPS6KB2 SRC APPL1 AKT1 PRKACA-1 EIF4EBP1 FOXO1-1 MAPK1 CGA MAPK3 FSHB MTOR SGK1-1 RPS6KB1 FSHR RPS6 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling VCAM1 IL6 BIRC5 MMP1 BIRC2 BIRC3 CCND1 CSF2 BCL2A1 CFLAR MMP3 IL1A BCL2L2 CXCL2;CXCL3;CXCL1-1 IL2 RELB MMP2 MMP9 REL EGLN2 IL1B CD40LG CHUK CXCL8 ICAM1 IKBKB RELA TRAF6 NFKB1 TNFRSF1A TNF VEGFA NFKB2 PTGS2-2 SELE 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TERT CTSB CTNNB1 BLK MAPK1 SLC2A4 FDFT1 MSRA MAPK3 SGPL1 MTMR8 BMP1 TERF1-1 MTMR6 CGAS S100A10 MEPE NEIL2 AXIN1 PPP1R3B SOX7 RAF1 MTMR9 MTMR7 RP1L1 CSTA NUMA1 CTSD PINX1 TLR2 HEPACAM2 SLC35G4;SLC35G5;SLC35G3;SLC35G6 MCRS1 PDX1 C8orf74 TLR4 DEFB135 SLBP NKX6-1 CLDN23-1 TBX5 TNKS MFHAS1 GATA4 HSPD1 FAM167A XKR6 ERI1 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2874%HOMO SAPIENS Liver X receptor pathway SREBF1 ABCG8 RXRA ABCG5 NR1H3 CYP2B6 SCD FASN CYP7A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260410%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway SMAD2;SMAD3 E2F1 PAK2 BAD ARAF E2F2 CDK4 E2F3 MAP2K2;MAP2K1 MAPK1 RAD51 MAPK3 CDKN1A BRAF MAPK10 CDC42 KRAS BAK1 RAF1 PLD1 CHUK GADD45B EGF GADD45A GADD45G BAX RPS6KB2 IKBKB PIK3CD BRCA2 AKT1 IKBKG CDK6 BCL2L1 RAC3 NFKB1 RALBP1-1 RAC1 JAK1 RALGDS TP53 TGFB2 TGFB1 TGFB3 DUSP6 RALA-1 PIK3R2 PIK3R1 CCND1 EGFR AKT3 PLD2 STAT1 AKT2 DDB2 STAT3 PAK3 MTOR PAK5 POLK RPS6KB1 PAK4 TGFA TGFBR1-1 PIK3CB CDKN2A ERBB2 SMAD4 RALB BUB1B-PAK6;PAK6 PEBP1 TGFBR2 PRKCD RB1 RELA MAPK9 PIK3R3 VEGFA CASP9 PIK3CA RIPK4 ARHGEF6 PAK1 MAPK8 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260410%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH DUOX1 DUOX2 ANO1 CREB1 PLCD1 CLCN5 TG RAP1A ELK1 MAP2K2;MAP2K1 PRKAA1 MAPK1 MAPK3 PRKAA2 RAF1 SLC5A5 PRKCA TPO NFKB1 SLC26A6 RAP1B CGA TSHR ACY1;ABHD14A-ACY1 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260410%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 ANGPTL3 LDLR CETP APOA4 LCAT LPL LIPC PLTP ANGPTL4 APOC2 APOA2 APOA1 APOA5 LRP1 SEL1L LMF1 GPIHBP1 ANGPTL8 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer WNT16 SMAD2;SMAD3 FOXQ1 EED MAP2K2;MAP2K1 MAPK1 WNT6 LATS2 FOXC2 WNT11 HRAS MAP2K6 MAPK3 RBPJ MAP2K3 WNT1 ZEB2 MAP2K4 WNT2 WNT3 DLK1 FZD1 GDF15 WNT10B MAPK14 WNT10A MAPK12 FZD3 MAPK13 FZD2 FZD5 GRB2 KRAS SOS1 WNT7B RAF1 FZD7 SNAI1 FZD6 FZD9 SOS2 FZD8 WNT7A AKT1 PIK3CD EZH2 ID2-1 MPP5 ID1 TP53 CLDN3 FN1 PIK3R2 PIK3R1 CLDN5 LRP5 LRP6 MEF2D NOTCH1 SNAI2 DLL1 DLL3 DLL4 CLDN4 CDH2 PKD1 PIK3R3 CLDN23-1 PROX1 PAK1 MAPK8 TUSC3 PDCD6 CLDN2 CDKL2 CLDN6 CLDN9 CLDN8 PKP2 PKP1 EIF5A2 NRP2 CLDN20 DSP CLDN22;CLDN24-1 CLDN11 NUBPL CLDN10 FOXM1 CLDN15 CLDN14 CLDN12 CLDN19 STRAP MMP2 CLDN18 CTDSP1 CLDN17 MMP9 CLDN16 TMPRSS4 OCLN-1 CRB3 MMP15 RBBP4 NR2C2 SPARC CDH1 TRAF6 TGFB2 TGFB1 TGFB3 WNT4 JAG2 ZEB1 JAG1 JUP FZD4 GSK3B MAPK11 AKT3 CTNNB1 VTN WNT9B WNT9A AKT2 CLDN7 WNT8A WNT8B TGFBR1-1 PIK3CB SUZ12 CLDN1 FMNL2 SMAD4 WNT3A ITGA5 WNT5A TGFBR2 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 WNT2B COL4A5 NOTCH2 FZD10 NOTCH3 HIF1A NOTCH4 TJP1 TWIST2 WNT5B SHC1-1 PIK3CA FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260410%WP206%HOMO SAPIENS Fatty acid omega oxidation ADH4 CYP1A1 ALDH2 ALDH1A1 CYP2E1 CYP2D6;LOC107987479;LOC107987478-1 ADH1C;ADH1B;ADH1A CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A2 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260410%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine ASMT DBH DNAJC12 PTS PNMT SPR COMT QDPR GCH1 AANAT MAOB DHFR2;DHFR TH MAOA PAH LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260410%WP3935%HOMO SAPIENS Leptin insulin signaling overlap PIK3CG JAK2 PDPK1 INSR SOCS3 IRS1 SOCS1 SOCS2 AKT1 IRS2 DGKZ STAT3 PIK3R3 INS;INS-IGF2 LEPR IRS4 LEP MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260410%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis GZMH;GZMB-1 VCAM1 IL6 MAP3K7 TLR8 TLR7 IL10 LCN2 IL1A RELB IRF1 CCL4L2;CCL4L1;CCL4 REL MAPK14 ELANE IRF5 IRAK1 CHUK CXCL8 IRAK4 ICAM1 IKBKB NFKBIA IKBKG TRAF3 RELA TRAF6 NFKB1 IRF7 TAB2 CCL3L1;CCL3L3;CCL3;CCL18 TAB1 TLR4 TNF MYD88 NFKB2 MAPK8 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260410%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A2 SLC2A1 GLP1R IL6 GCG INS;INS-IGF2 IL6R NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260410%WP4331%HOMO SAPIENS Neovascularization processes PDGFB TGFB1 TGFB3 SMAD2;SMAD3 JAG1 CXCL12 KIT FLT4 MAPK1 SMAD1 RELB ACVRL1 MAPK3 SMAD9 SMAD5 MMP9 REL TGFBR1-1 NOTCH1 CXCR4 DLL4 ANGPT1 EPHB2 AKT1 EPHB4 NOTCH3 HIF1A NOTCH4 RELA MAPK9 NFKB1 KDR KITLG NFKB2 MAPK8 TGFB2 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260410%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide IRF3 IFNG BECN1 TRAF6 NFKB1 TLR4 TLR9 TNF MYD88 IFNB1-4 MAP1LC3A DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260410%WP710%HOMO SAPIENS DNA damage response only ATM dependent MYC WNT16 SMAD2;SMAD3 BAD BIK NRAS MAPK1 WNT6 G6PC1 WNT11 HRAS DVL1 DVL2 DVL3 WNT1 WNT2 CDKN1A WNT3 JUN TP73 MAP3K1 WNT10B TCF7L2 WNT10A MAPK10 TCF7L1 CCND3 GRB2 KRAS SOS1 WNT7B PCK2 SOS2 RBL2 WNT7A FOSL1 IRS1 AKT1 PIK3CD RAC3 RAC1 CAT TP53 MDM2-2 PIK3C3 PIK3R4 PIK3R2 PIK3R1 SCP2 PMAIP1 HMGB1-1 CDKN2A LEF1 MAP3K4 FASLG PIK3R3 FOXO3 PIK3R5 MAPK8 MAP3K7 BCL2 PPP2R5C RHOA PDK1 MLKL BCL6 CDC42 CCNG2 BAK1 INSR BAX NFKB1 TGFB1 LDLR WNT4 GSK3B TCF7 CCND1 AKT3 CTNNB1 AKT2 ATM PTEN PIK3C2G PIK3CB PIK3C2A PIK3CG ERBB2 SMAD4 CDKN1B PIK3C2B WNT3A WNT5A AXIN1 APC WNT2B CCND2 MAPK9 PLAU BCL2L11 ABL1 WNT5B NFKB2 SHC1-1 PPP2R5E PIK3CA BBC3 HEART DEVELOPMENT%WIKIPATHWAYS_20260410%WP1591%HOMO SAPIENS Heart development FGF10 HEY1 BMPR2 HEY2 NKX2-5 NFATC3 CTNNB1 MAPK1 FOXC2 SMAD1 SHH BMPR1A PTPN11 FOXC1 TBX1 VEGFB VEGFC SMAD4 NFATC4 BMP4 NOTCH1 BMP2 BHLHE40 BMP10 TBX20 SMYD1 IRX4 FOXH1 ISL1 NFATC1 TBX2 FGF8 HAND1 MEF2C FOXA2 NFATC2 GATA6 SRF TBX5 ERBB3 VEGFA GATA4 PITX2 HAND2 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260410%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity DDX58 TBK1 IFIH1 IRF9 MAVS IKBKE IFNAR1 IFNB1-4 TICAM1 IRF3 TRAF3 ACE2 STAT1 STAT2 JAK1 IFNAR2 TLR3 TYK2 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260410%WP12%HOMO SAPIENS Osteoclast signaling PDGFB TRPV5 SLC9A1 IFNAR1 IFNB1-4 AIMP2 GPR68 CTSK ACP5 TNFRSF11A ATP6V1G1 ITGB3 TNFRSF11B TNFSF11 MAPK8 SPP1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway CASP8 CASP10 FADD CXCL10 MAP3K7 CXCL12 TRADD NFKBIB ISG15 TRAF2 MAP3K1 MAPK14 MAPK12 ATG5 MAPK10 MAPK13 TBK1 IKBKE IFNB1-4 CHUK CXCL8 IKBKB NFKBIA OTUD5 IRF3 IKBKG AZI2 TRAF3 DDX17 TRAF6 SIKE1 IRF7 NFKB1 RNF125 IFNE TKFC RIPK1 DDX3X-1 IFNK CYLD PIN1 TBKBP1 NLRX1 SNW1 ATG12-1 MAPK11 DDX58 IFNG IFIH1 MAVS STING1 TRIM25 TANK RELA MAPK9 TNF DHX58 MAPK8 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ABCA1 MYLIP GGPS1 ACSL1 IDI2 HMGCS2 IDI1 ACAT2 FDPS MVK CYP51A1 ACSL3 DHCR24 MSMO1 LSS EBP PMVK SREBF1 SC5D NR1H3 MVD HMGCR LBR FDFT1 HMGCS1-1 SCD TM7SF2 NSDHL CYP27A1 FADS2 ELOVL5 ELOVL2 CYP46A1 CYP7A1 ACOT2;ACOT1 NR1H2 ABCG1 CH25H HSD17B7 ELOVL4 ELOVL3 PLPP6 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260410%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance HIF1A BCL2L1 WNT6 TP53 CDKN1A ABCB1 PURINERGIC SIGNALING%WIKIPATHWAYS_20260410%WP4900%HOMO SAPIENS Purinergic signaling GNAT2 P2RY4 P2RY12 GNAT3 P2RY2 ADORA3 P2RY1 GNAT1 ADORA2B GNAZ P2RY10 P2RY14 P2RX7 P2RX5 ADORA2A P2RX4 P2RX3 P2RX2 PANX1 P2RX1 P2RX6 LPAR4 GNA11 GNAS-1 GNAI3 LPAR6 GNAI1 GNAI2 P2RY13 P2RY11 GNAO1 P2RY8 ADORA1 P2RY6 ESTROGEN SIGNALING%WIKIPATHWAYS_20260410%WP712%HOMO SAPIENS Estrogen signaling BRAF GNB1 MAPK14 CREB1 CHUK GNAS-1 GPER1 ELK1 IKBKB SP1 AKT1 PRKACA-1 MAP2K2;MAP2K1 IKBKG GNGT1 NFKB1 MAPK9 MAPK1 FOS BCL2 ESR1 PIK3CA JUN PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260410%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response NARS1 NFE2L2 ATF4 ATF3 DNAJB9 EDEM1-1 ASNS UBE2E1 PDIA6 WARS1 DNAJC3-1 DNAJB11 PPP1R15A ERP27 TRIB3 HSPA5 EIF2AK3 EIF2A XBP1 ATF6 HSP90B1 CALR-1 BCL2L11 ERN1 DDIT3 BBC3 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP4159%HOMO SAPIENS GABA receptor signaling GABRA2 GABRQ GABRP GABRA1 GABRA6 GABRA5 AP2A1 GABRA4 GABRA3 GABRG1 AP2S1 SLC6A1 GABBR1 SLC32A1 SLC6A11 AP2B1 ALDH9A1 GAD2 GAD1 AP2M1 GPHN GABRB3 GABRB2 GABRB1 GABBR2 ABAT AP2A2 GABRG3;GABRG2 GABRE GABRD CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MYL2 LIN28B DKK1 MYH6 ROR2 MESP2 INS;INS-IGF2 POU5F1;POU5F1B NANOG;NANOGP8 ZFP42 MAPK14 BMP4 TBX20 IRX4 ISL1 KDR GATA4 NOG TGFB1 IGF2 IGF1 MYLK3 GSK3B NODAL NKX2-5 SCN5A KIT MESP1 SOX1 SIRPA;SIRPB1;SIRPG THY1 BMP1 TBXT LIN28A FGF2 WNT3A ACTC1;ACTG2 NRG1 NOTCH1 PDGFRA CXCR4 TNNI3 INHBA NCAM1 PAX6 MIXL1 MEF2C FOXA2 SOX17 SOX2 TBX5 ANPEP TNNT2 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260410%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression PBK MKNK1 TSC2 MKNK2 RAF1 PIK3R2 PIK3R1 MAP3K11 PIK3CD AKT1 MAP2K2;MAP2K1 EIF4EBP1 PRKAA1 MAP3K5 TSC1 EIF4E MAPK1 PIK3R3 MAP2K6 MAPK3 MTOR MAP2K3 PIK3CA PIK3CB ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260410%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology TGFB1 TGFB3 SMAD2;SMAD3 WWTR1 TMPO LEMD3 NRAS MAP2K2;MAP2K1 MAPK1 LBR HRAS EMD MAPK3 KIF5B BANF1 RHOA SYNE4 ADCY4 SYNE3 SMAD4 SUN1 PLEC GRB2 ADCY1 KRAS SOS1 ADCY8 ADCY7 ADCY6 SOS2 ADCY5 ADCY3 CFL1 ADCY2 ADCY9 MAP3K9 SYNE2 SYNE1 TMEM43 ADCY10 SRF CCN2 TGFB2 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases ANXA2 LDLR ABCA1 CETP MTTP LCAT LPL LIPC APOC2 APOA2 APOA1 SCARB1 PCSK9 LIPG APOE LDLRAP1 APOB FRAGILE X SYNDROME%WIKIPATHWAYS_20260410%WP4549%HOMO SAPIENS Fragile X syndrome CAMK1 PRKAR1A PPP3CA AP2A1 GAB1 DNM1 ARAF DAG1 EPHA4 MAP2K2;MAP2K1 DNM2 TTI1 MAPK1 AP2S1 AKT1S1 AP2B1 CYFIP1 FMR1 PTPN5 BRAF GRB2 KRAS SOS1 MKNK1 RAF1 MECP2 HCN1 EIF4A1 GAD1 AKT1 RAP1GAP PRKACA-1 TSC1 GPHN RPTOR CAMK4 MLST8 CLTCL1 GABRB2 GABRG3;GABRG2 CPT1A GABRD CREB1 GABRA1 RHEB ALDH3A2 ABCD3 MAP1LC3B2;MAP1LC3B-1 FYN DICER1 EIF4E TARBP2 PTPN11 MTOR AGO2 RPS6KB1 CDKN2A NF1 CAMK2B CAMK2A DEPTOR GRIN2A KCND2 SYNGAP1 CLTC CLTB HOMER1 CLTA DLG4 BDNF AKAP5 EIF4G1 ARC GRIA2 MMP9 SLC16A1 APP PDK1 GRIN2B NTRK2 GRM1 GRM5 ABAT TELO2 PPP1CA GRIN1 SLC6A1 GRIP1 PTEN PIK3CB SH3GL3 CYFIP2 ITPR1 SH3GL1 GRIP2 TSC2 TBC1D7;TBC1D7-LOC100130357 HOXB8 CNR1 PRKCA AGAP2 EIF4EBP2 EEF1A1 ARHGAP32 KCNC1 TECR SRC AP2M1 DLGAP3 PLCG1 DUSP3 ALDH5A1 PICK1 SHANK1 EPS8L1 MAP1B SHC1-1 PPP2R5B GRIA1 PLCB1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260410%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway CREB1 RASGRP1 RAP1A ELK1 MAP2K2;MAP2K1 HTR1A MAPKAPK3 MAPK1 MAPKAPK2 MAP2K6 STAT3 MAPK3 RASGRF1 MAP2K3 RHOA MAP3K1 BRAF MAPK14 JAK2 ITPR1 HTR2A PDPK1 ELK4 GNAI3 GNAI1 GNAI2 HTR1E HTR1F RPS6KA5 HTR1D FOS HTR1B SRF PIK3CA GNAO1 GNAQ INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260410%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB2 PTK2 MOB1A;MOB1B PKN3 PIK3R2 PKN1 PIK3R1 AKT3 TEAD1 TEAD2 TEAD3 TEAD4 MAPK1 LATS1 LATS2 AKT2 MTOR PKN2 RHOA PIK3CB ROCK1 PLCB3 YAP1-1 TSC2 TRIO PIK3CD AKT1 TSC1 PIK3R3 PLCB4 PIK3CA GNAQ PLCB1 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260410%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling SMAD2;SMAD3 FGFR1 GAB1 ELK1 MAP2K2;MAP2K1 PCNA MAPK1 SIX1 MAPK3 ZEB2 FZD1 JUN WNT10B MAPK14 IGF1R ACACA GRB2 RPS6KA1 RAF1 PDPK1 CXCL8 AKT1 CRKL RPS6KA4 RPS6KA5 FOS TP53 RPS6 CPT1A CCL13;CCL2 IL6 DUSP6 FN1 SMAD6 PIK3R1 CLDN5 SOCS3 CSF3 SOCS1 CSF2 CXCL2;CXCL3;CXCL1-1 NR4A1 MTOR RPS6KB1 PDCD4 IL1B SNAI2 CDH2 HSPB1 TNF ACTA2 MAPK8 HK2 VIM CXCL10 NR0B2 PARP1 ITGB1 PPARGC1A FLT1 SMAD1 SMAD9 SMAD5 MMP9 LDHA OCLN-1 SLC2A1 PRKAA2 IFNB1-4 SP7 RPS6KA3 CDH1 NFKB1 KDR CXCL5;CXCL6 TGFB1 ZEB1 DUSP1 PTK2 GSK3B IL10 CTNNB1 PDGFRB MST1 DUSP4 PTEN CLDN1 KLK15 PDGFRA PRKCB COL4A1 SRC PLCG1 NDRG1 RELA MAPK9 TJP1 SLPI EGR1 MST1R IBSP ABL1 VEGFA SHC1-1 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260410%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids GPAM GPAT4 PNPLA2 DGAT2 CRLS1 PNPLA3 PLD1 PISD PLA2G1B PCYT1A CHKB PCYT2 DGAT1 PTDSS2 PTDSS1 DGKZ ETNK1 PEMT CDIPT CDS1 CHPT1 AGPAT4 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260410%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome C5 LMNA CFD C3-1 LMNB2 FNTA RCE1 LMNB1 ICMT CFB CELL CYCLE%WIKIPATHWAYS_20260410%WP179%HOMO SAPIENS Cell cycle MYC ANAPC7 CHEK2 ANAPC4 ANAPC5 SMAD2;SMAD3 ANAPC2 E2F1 ANAPC13 PKMYT1 CDKN2B ANAPC10 ANAPC11 ORC5 ORC4 PLK1 CDC25A ORC6 CDC25B ORC3 YWHAB HDAC2 ORC2 HDAC1 STAG2 CDK4 CDC16 E2F2 PTTG1;PTTG2 E2F3 CDK1 SMC1B DBF4 PCNA FZR1 BUB1 CDKN2D WEE2 CDKN1A SKP2 YWHAE SKP1 CCND3 RBL1 GADD45B GADD45A YWHAH GADD45G RBL2 CDK6 YWHAZ CCNE1 TP53 MDM2-2 CDK2 CCNE2 EP300 E2F4-1 WEE1 STAG1 CDKN2A CCNA1 TFDP1 TFDP2 SFN TTK E2F5 CCNB2 ORC1 YWHAG CDC7 RB1 PRKDC ESPL1 MAD1L1 CDKN1C CUL1 CDK7 CDC25C BUB3 MCM2 ANAPC1 CDC45 CHEK1 ATR YWHAQ TGFB2 TGFB1 TGFB3 CCNB3 GSK3B CCND1 CCNA2-1 CDKN2C CDC6 MCM7 RAD21 ATM MCM3 SMC3 CCNB1 MCM4 SMC1A MCM5 MCM6 SMAD4 CDKN1B MAD2L2 RBX1 CCND2 ABL1 ZBTB17 CCNH CDC14A CDC14B CDC20 CDC23 CDC27 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260410%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK2 TRIM28 EXO1 CASP3 E2F1 UPF1 CDC25C FANCD2 PARP1 MCPH1 APAF1 RNF8 PCNA LATS1 RAD51 TP53BP1 CHEK1 TP73 RAD52 RAD17 ATR RAD9A YAP1-1 BAK1 CDK5 ATF2 BAX BRCA2 RIF1 RASSF1 TRAF6 BID TP53 MDM2-2 TERF2 HSF1 NABP2 DCLRE1C MDC1 RAD50 MRE11 ATM NBN BRCA1 CDKN2A SMC3 KAT5 SMC1A ACTL6A PRKDC STK3 ABL1 CASP9 BLM ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2858%HOMO SAPIENS Ectoderm differentiation MYC ROR2 PTPN13 CTBP1 BOC NLK CELSR2 GLI3 POU2F2 RGMA HDAC10 SHH TSKU NARS2 ANKS1B KCNK10 GRAMD1B-1 WNT1 KRT6B;KRT6C;KRT6A CDON MZF1 ASTN1 SPRY2 LY6E TFAP2A ARX STC1 ARHGAP15 ZBTB2 TRPM2 TCF7L1 ST8SIA4 BMP4 HESX1 FZD5 ELOVL2 ZBTB7B SKIL GREB1 MECP2 PAN2 PLCXD3 FZD8 PTPRB NFATC1 PPFIBP2 MAFB CCDC88C CCDC130 EDA LDB2 EDA2R WDR44 PHF8 SIX6 UBTF BCOR RAB8B BCAS3 TSC22D1 SORCS1 NR2F2 BAZ1A FOXL1 ARHGAP10 CCL13;CCL2 KIFC3 STX16 RRBP1 JAKMIP1 SERPINB6-2 OGT-1 CLVS1 SMURF1 CAP2 TTC14 C1GALT1 VAX2 RIT1 SGSM3 ZNF219 PRKAG2 TRIM33 MYORG SOCS2 FYN FHL2 ABCC4 PLXNA2 PIM1 HMGB2 CDH8 CDH6 DMD ARHGDIG PAX6 NUMA1 IQCJ-SCHIP1;SCHIP1 CTNND2 TLE5 PGM1 NF2 SDCBP GLB1 GAS2L1 AHI1 CLDN11 PDE7A SNCA MKS1 GATA6 NLGN1 ELOVL4 ZFHX4 TFAP2C LHX1 JUP FZD4 CTNNB1 FGFR2 BMPR1A CTNNA2 PPARD PAX3 TOX3 SMAD4 HDAC6 FOXA2 PODXL TNFRSF11B SOX2 ZBTB16 PI4KA SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260410%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism ALOX5 FADS2 FADS1 ACSL1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260410%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAP2K5 PIK3R2 PIK3R1 CSNK2A1;CSNK2A3 EIF4A2 AKT3 EIF4G3 EIF4G1 MAP2K2;MAP2K1 EIF4EBP1 EIF4E MAPK1 EIF4B MAP2K7 AKT2 MAP2K6 MAPK3 MTOR MAP2K3 MAP2K4 RPS6KB1 PIM1 PDCD4 PIK3CB PIK3CG MAPK14 MAPK10 PDK1 RPS6KA1 PIM2 PRKCD PRKCA RPS6KA2 EIF4A1 RPS6KB2 AKT1 PRKACA-1 RPS6KA4 MAPK9 RPTOR RPS6KA5 PIK3R3 PIK3CA RPS6 MAPK8 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH NMRK2 MDH2 TFE3 HSPE1 SLC19A2 CS NONO NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260410%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease VCAM1 CYP2E1 SREBF1 PRKAA1 NR1H3 PPARA ITCH JUN CXCL8 COX4I2 NDUFB9 IRS1 IKBKB AKT1 PIK3CD IRS2 MAP3K5 RAC1 PRKAB2 PRKAB1 DDIT3 CCL13;CCL2 PKLR RXRA IL6 IL6R PIK3R2 PIK3R1 PRKAG1 PRKAG2 SOCS3 PRKAG3 NDUFA11 COX6A1 COX6A2 COX6B2 COX6B1 UQCRC1 UQCRC2 UQCRB COX7A2 CYC1 COX7B2 UQCRQ COX7B COX4I1 COX7C MLX COX8A COX8C NDUFS8 IL1B SDHC NDUFS7 SDHD COX7A2L-1 SDHA NDUFA4L2 SDHB UQCR11 UQCR10 COX5B COX5A MLXIP NDUFA4 GSK3A FASLG TNF PIK3R3 ERN1 CYCS-1 CASP7 NDUFB8 NDUFB7 NDUFB10 MAPK8 CASP8 NDUFB6 NDUFA12 NDUFB5 NDUFB11 CASP3 NDUFB4 NDUFB3 CEBPA NDUFB2 NDUFB1 ATF4 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 MAP3K11 NDUFV1 NDUFA8 NDUFA7 IL1A NDUFA6 ADIPOR2 NDUFA3 NDUFC1 ADIPOQ INS;INS-IGF2 NDUFS6 FAS NDUFAB1 NDUFS4 NDUFS3 LEP NDUFS2 TRAF2 NDUFS1 NDUFS5-1 EIF2AK3 PRKAA2 CDC42 BAK1 SMAD7 INSR BAX COX6C NFKB1 TNFRSF1A BID TGFB1 UQCRFS1 GSK3B AKT3 AKT2 PIK3CB EIF2S1 NR1H4 NDUFA13 NDUFA10 XBP1 NDUFA9 NDUFA5 RELA MAPK9 BCL2L11 LEPR ADIPOR1 PIK3CA BBC3 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260410%WP536%HOMO SAPIENS Calcium regulation in cardiac cells PRKAR1B CAMK1 PRKAR1A YWHAB PRKAR2B PRKAR2A YWHAE RYR2 PLCB3 CACNA1D CACNA1C GNAS-1 YWHAH GJB6 GNAI3 ADCY3 ATP2A3 ADCY2 PRKACA-1 YWHAZ GNAI1 GNAI2 CAMK4 GNG2 GNAO1 GNAQ GNB1 ATP2B1 CAMK2B CAMK2D CAMK2A SFN YWHAG GNA11 CAMK2G SLC8A1 RGS4 RGS5 RGS3 ADCY9 GJA3 RGS1 GJA5 GJA4 CALR-1 GJA9 GJA8 RGS6 RGS7 ATP1B2 CALM3;CALM1 CACNB3 CALM2 RYR3 STIM2 CACNA1B CACNA1A GRK5 CACNA1E GRK4 GJC1 GRK6 RGS2 ITPR3 GJC2 PKIB GJB2 GJB1 GJB4 FKBP1A GNAZ GJB3 GNG13 PKIA GJB5 GNB2 PKIG GNB4 GJD2 GNB3 CASQ2 GNB5 RGS18 RGS17 RGS19 RGS14 RGS16 ATP1A4 GNGT1 RGS20 KCNJ3 KCNJ5 KCNB1 ATP1B3-1 ATP2B3 ATP2B2 SLC8A3 RGS11 ADCY4 PRKCZ ADCY1 ADCY8 CHRM3 ADCY7 CHRM1 ADCY6 CHRM4 ADCY5 CHRM5 PRKACB-1 ATP2A2 GNG5 ADRB1 GNG4 ITPR2 GNG8 YWHAQ ADRB3 ADRA1D ADRA1B ADRA1A ARRB1 ARRB2 CACNB1 PRKCG ORAI1 CASQ1 ATP1B1 PRKCQ CACNA1S ANXA6 PRKD1 RGS9 ITPR1 PRKCH PRKCB PRKCE PRKCD GJA1 PRKCA RYR1 RGS10 FXYD2;FXYD6-FXYD2 ADRB2 CHRM2 CALM1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism FUT2 FUT6;FUT5;FUT3 B3GALT2 FUT1 B3GALT1 B3GNT5 HEPATITIS B INFECTION%WIKIPATHWAYS_20260410%WP4666%HOMO SAPIENS Hepatitis B infection MYC SMAD2;SMAD3 BIRC5 BAD YWHAB ARAF ELK1 NRAS MAP2K2;MAP2K1 PCNA MAPK1 MAP2K7 HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 CDKN1A JUN MAP3K1 BRAF MAPK14 MAPK12 MAPK10 MAPK13 GRB2 KRAS SOS1 RAF1 ATF2 SOS2 CXCL8 NFATC1 IKBKB AKT1 PIK3CD IKBKG YWHAZ TLR2 FOS JAK1 EGR2 TYK2 CREB1 IL6 IFNAR1 PIK3R2 PIK3R1 CREBBP NFATC3 STAT4 EP300 STAT5A SLC10A1 STAT1 STAT2 STAT3 DDX58 IFIH1 MAVS CREB3L3 CREB3L4 EGR3 CREB3L2 NFATC2 FASLG TNF PIK3R3 CASP9 TICAM2 CREB3 CYCS-1 TLR3 CREB5 MAPK8 CASP8 CASP10 CASP3 FADD MAP3K7 ATF4 APAF1 BCL2 FAS HSPG2 MMP9 ATP6AP1 DDB1 TBK1 IRAK1 IKBKE IFNB1-4 CHUK IRAK4 TICAM1 BAX TIRAP IRF3 ATF6B TRAF3 TRAF6 NFKB1 IRF7 TAB2 TAB1 YWHAQ TLR4 MYD88 DDX3X-1 BID TGFB2 TGFB1 TGFB3 VDAC3 MAPK11 CREB3L1 AKT3 AKT2 DDB2 PRKCG STAT6 TGFBR1-1 PIK3CB SMAD4 NFATC4 JAK2 JAK3 PRKCB TGFBR2 PRKCA SRC RELA MAPK9 PTK2B STAT5B PIK3CA MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260410%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 ERBB4 MYC CAV1 GJB2 PGR CEBPA CEBPB CLDN6 EGFR CCND1 EIF4G1 EIF4E TNFRSF11A ESR2 STAT5A CSN2-1 PRLR NFIA ESR1 ORAI1 ELF5 PNCK ATP2C2 ERBB2 DLGAP4 TFPI2 JAK2 USF2 TTC9 NRG1 GAL NFIC HDGFL2 YY1 PRL CHUK TPM3 BCL2L1 NFIX USF1 NFIB NR3C1 STAT5B PTPN1 TNFSF11 ERBB3 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260410%WP4747%HOMO SAPIENS Netrin UNC5B signaling VCAM1 CASP3 MAP2K2;MAP2K1 ITGB4 IL1A MAPK1 RGMA MAPK3 NTN4 NTN3 RHOA JUN MAPK14 YAP1-1 UNC5B RAF1 CIP2A DCSTAMP RLF PLEKHH1 ICAM1 MYF5 AKT1 ALPL KDR RAC1 NEO1 CCN2 TP53 CCL13;CCL2 PPP1CA ROBO4 PTK2 IL10 PTPA FYN PTPN11 ARHGEF12 DAPK1-1 COL1A1 NTN1 INPP5D CDH5 PRKCA AGAP2 PPP2R1B SRC PTK2B TNF PIK3CA SELE ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260410%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 ESR1 SP3 SP1 KCNN3 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260410%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGA PIGK PIGM MPPE1 PIGL PIGG PIGH PIGF PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGQ PIGP PIGW PIGV PIGX-1 PIGC DPM2 PIGB BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260410%WP2366%HOMO SAPIENS Butyrate induced histone acetylation AKT1 ACLY PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation TUBA1A VLDLR DYNC1H1 CLIP1 DCX PAFAH1B3 NDEL1 PAFAH1B1 NUDC RELN PAFAH1B2 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260410%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia MYC BCR CDKN1B PDGFRA NOP2 PIM2 GADD45A SPRED2 ABCB1 PDGFRB FLT1 KIT ABL1 LYL1 FOXO3 CSF1R PIM1 GAB2 ABCG2 SKP2 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260410%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR MMP1 PTGES2 EGFR PLA1A AKT3 NRAS MAPK1 AKT2 HRAS MAPK3 ESR1 CYP19A1 PIK3CB BRAF PIK3CG KRAS SRC PIK3CD AKT1 PTGER4 PTGS2-2 PTGER1 PIK3CA PTGER2 PTGER3 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260410%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC2H1 IFT140 IFT80 WDR35 DYNC1I2 IFT43 WDR19 DYNC2I2 IFT22 DYNC2I1 IFT81 IFT122 HSPB11 DYNLRB2 DYNLRB1 IFT27 DYNC1I1 DYNLT1 DYNC1H1 IFT46 DYNLT2B DYNC1LI1 DYNC2LI1 DYNC1LI2 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260410%WP2361%HOMO SAPIENS Gastric cancer network 1 CEP192 H3-3A INO80D LIN9 KIF15 ESM1 RNF216 MYBL2 ECT2 UBE2C TPX2 SMOC2 GATD3B;GATD3A KIF20B TOP2A CCNA1 MCM4 H4-16 ACTL6A NOTCH1 S100P APC AURKA E2F7 NUP107 CENPF RUVBL1 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260410%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAR1B PRKAR1A PRKAG1 PRKAG2 PRKAR2B PRKAR2A PRKAG3 AKT3 PRKAA1 BCKDHA PDHA1 ACSBG1 AKT2 LIPE ABHD5 FASN PLIN1 PNPLA2 ACSS2 PRKAA2 ACACA ACLY PRKACB-1 AKT1 PRKACA-1 PRKAB2 PRKAB1 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260410%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SLIT2 ROBO4 KDR RAC1 VEGFA SRC 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260410%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb EEF2K NDUFV1 CDK1 MAP2K2;MAP2K1 PRKAA1 CDR2 MAPK1 MAPK3 NDUFS3 CDH18 MAPK14 MAPK12 PRKAA2 MAPK13 RPS6KA1 RPTOR MLST8 PRKAB2 PRKAB1 TRAP1 UQCRFS1 CDK2 PRKAG1 PRKAG2 MAPK11 PRKAG3 UQCRC1 UQCRC2 UQCRB MTOR RAB5IF CYC1 TRPM7 RPS6KB1 PDZD9 UQCRQ SDR42E2 VWA3A COX7C MOSMO-1 EEF2 POLR3E NDUFS8 UQCR11 UQCR10 COX5A NDUFA9 NDUFA4 CALM1 CALM3;CALM1 CALM2 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260410%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP UBE2D1 ANAPC7 ANAPC4 EHMT1 ANAPC5 ANAPC2 CDKN2B ANAPC10 ANAPC11 CEBPB H2AC4 CDK4 CDC16 ANAPC1 UBE2S IL1A FZR1 MAPK1 CDKN2D H2BC5 MAPK3 H2BC1 H2AC14 CDKN1A H2BC21 H2AC20 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 JUN H4-16 UBB;UBC RPS6KA1 MAPK7 H4C1 H4C6 CXCL8 RPS6KA3 CDK6 UBA52 NFKB1 FOS RPS27A H2AZ2;H2AZ1 IL6 H2AJ H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDK2 H2AB2;H2AB3;H2AB1 H3-3A H2BC15;H2BC3;H2BC11;H2BC12 CCNA2-1 CDKN2C UBE2E1 UBE2C STAT3 CDKN2A CCNA1 CDC26 CDKN1B ANAPC15 ANAPC16 IGFBP7 RPS6KA2 RELA EHMT2 CDC23 CDC27 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260410%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2C18-1 PPARA EPHX2 PPARG METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260410%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PGM1 GCK GLUD1;GLUD2 FGFR4 PSAT1 FGFR1 PYCR1 PSPH CD36 SERPINH1 RHOA BMP1 LDHA SLC16A1 SLC2A1 LPAR1 PLOD1 LOXL2 ADAMTS2 P3H4 P3H3 P4HA1 P4HA3 ALDH18A1 P4HA2 PLCG1 SLC1A5 GLS PHGDH UGDH GPI UGP2 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MECR ACACA HSD17B12 OXSM MCAT BURN WOUND HEALING%WIKIPATHWAYS_20260410%WP5055%HOMO SAPIENS Burn wound healing CD3E SMAD2;SMAD3 CASP3 FGFR4 MMP1 SFRP2 FOXE1 FGFR1 CXCL12 ACTA1 BCL2 MMP2 KRT6B;KRT6C;KRT6A MMP9 MMP28 FBN1 IFNB1-4 FGFR3 EGF CXCL8 BAX ICAM1 AKT1 CXCR2 LGALS1 NFKB1 IL15 TLR4 MYD88 CHRNA7;CHRFAM7A TP53 TIMP1 COL1A2 KLF4 CCL13;CCL2 TGFB2 TGFB3 IL6 TNC FST FGFR2 ACHE PDGFRB CXCL2;CXCL3;CXCL1-1 SERPINH1 PECAM1 HMGB1-1 LIN28A DCN IL1B COL1A1 HGF SNAI2 CXCR4 INHBA F13A1 S100A6 HEXD KRT222 BRD4 S100A9 SCEL S100A11 AMBP SLURP1 TNF TPT1 NOX4 CDK16 VEGFA FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260410%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling SMAD2;SMAD3 IGF1 MAPKAP1 GSK3B MSTN MAP1LC3A IGFBP5 ITGB1 WASL PPARGC1A EIF4E EIF2B2 AKT1S1 MTOR ILK RPS6KB1 PTEN PIK3CG PDK1 IGF1R TNFSF9 PLD1 IRS1 DEPTOR AKT1 ACVR2B NFKB1 RPTOR TNFRSF1A RICTOR NEB MLST8 TRIM63 FBXO32 PRKAB1 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling CUEDC2 SFTPD PELI1 RNF31 PELI3 PELI2 CTNNAL1 SARM1 PLK1 MAP2K2;MAP2K1 MAPK1 MAP2K7 MAP2K6 MAPK3 MAP2K3 MAP2K4 IL12B IL12A JUN MAPK14 MAPK12 MAPK10 MAPK13 CXCL8 IKBKB AKT1 PIK3CD IKBKG TLR2 FOS MLST8 RAC1 TREM1 IFNAR2 SYK BTK IL6 TLR1 TIFA SMAD6 TLR9 IFNAR1 TLR8 PIK3R2 PIK3R1 TLR7 TLR6 TLR5 SOCS1 ZMYND11 SQSTM1 STAT1 CISH MBL2-1 CCL4L2;CCL4L1;CCL4 PTPN6 IL1B IRF5 TMED7 RNF41 CCL3L1;CCL3L3;CCL3;CCL18 TNF CD86 PIK3R3 CD40 CD80 PIK3R5 LBP TICAM2 TNFAIP3 TLR3 LY96 MAPK8 SPP1 CD14 CASP8 TAB3 MAP3K8 FADD CXCL10 CXCL11 MAP3K7 CXCL9 TBK1 IRAK1 CCL5 IKBKE IFNB1-4 CHUK IRAK3 IRAK4 TICAM1 TIRAP NFKBIA OTUD5 IRF3 TRAF3 TRAF6 NFKB1 IRF7 TAB2 TAB1 TLR4 RIPK1 MYD88 CYLD IRAK2 TOLLIP MAPK11 AKT3 RNF216 AKT2 PIK3CB PIK3CG RELA MAPK9 USP7 NFKB2 FBXW5 PIK3CA CD180 RBCK1 TRAFD1 SIGIRR PDGFR BETA PATHWAY%WIKIPATHWAYS_20260410%WP3972%HOMO SAPIENS PDGFR beta pathway PIK3R1 ELK1 RASA1 MAP2K2;MAP2K1 PDGFRB EIF2AK2 STAT5A STAT1 HRAS STAT3 MAPK3 MAP2K4 STAT6 JUN MAP3K1 JAK2 GRB2 PRKCB SOS1 RAF1 PRKCA PLCG1 FOS STAT5B SRF JAK1 SHC1-1 PIK3CA MAPK8 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DISC1 ACTR1A ACTR1B PLK1 MYH11 BMERB1 DCP2-1 NDE1 RAP1A ABCC6 PLAGL1 MARF1 DCP1A ACTR10 RAPGEF4 ABCC1 KIAA0753 OFD1-1 DCTN6 PAFAH1B1 DCTN1 DCTN4 GATA3 PLAG1 CEP20 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260410%WP1422%HOMO SAPIENS Sphingolipid pathway PPP1CA GAL3ST1 GBA UGT8 CERS3 CERK SGMS1 ASAH2 GBA2 SPHK2 SPTLC3 SPHK1 CERT1 SGMS2 ACER1 SGPP2 SERINC1 B4GALT6 UGCG CERS4 ASAH1 SGPL1 CERS5 CERS6 PPP2CB;PPP2CA KDSR PLPP1 CERS2 SPTLC1 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260410%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway PDGFB TGFB1 TGFB3 DKK1 IL6 IL11 IGF1 IL6R FST FGF10 NODAL PDGFA GDF5 CNTF KIT CSF1 EPO SHH INS;INS-IGF2 TF NTF4 WNT1 WNT2 FGF1 FGF2 WNT3A HGF BMP4 NOTCH1 FGF4 WNT5A WNT7B INHBA EGF WNT2B FGF8 TPO CXCR1 LEFTY2;LEFTY1 NT5E IL3 TNFSF11 KITLG VEGFA ALK NOG FLT3LG CSF1R ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260410%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT1 AKT2 MTOR AKT3 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260410%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation CLIP1 GSK3B CFL2 DPYSL2 TPPP CDK1 MARK2 LIMK1 MARK1 RHO MAPKAPK2 DVL1 STAT3 MAPRE1-1 PTPRA TAOK1 KIF2C PTEN PARD6A PHLDB2 AURKB ROCK1 WNT3A SPRED1 CDC42 MAPT NTRK1 NTRK2 PRKCA APC TESK2 STMN1 NTRK3 DIAPH1 TRIO SRC EPHB2 AKT1 TIAM1 PRKACA-1 F2RL2 CAMK4 ABL1 RAC1 CLASP1 MAP1B PAK1 GNAQ HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260410%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway EGLN1 SLC2A1 SLC11A2 PDK1 ACACB ACACA NFE2L2 PRKAG1 KEAP1 HIF1A PRKAA1 PDHA1 VEGFA TP53 PRKAB1 CUL3 RPS6 PDHB LDHA CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260410%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis ZAP70 PPP3CA LCK HDAC2 CD4 HDAC1 CAPN2 CD8B;CD8B2 CD8A PLCG1 ATP2A1 EP300 NFATC2 CALM1 NR4A1 PPP3CB PPP3CC ITPRIP MEF2D CABIN1 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members DTX3L CUL1 SKP1 PARP11 HDAC2 PARP1 HDAC3 RBX1 STAT1 STAT3 PARP14 PARP9 BTRC STAT6 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260410%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SRRT WWTR1 SOX12 H4-16 POU3F1 UTF1 FGF4 SOX15 ZSCAN10 YES1 H4C1 H4C6 TEAD2 SOX2 SOX4 SOX11 POU3F2 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260410%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 WNT SIGNALING%WIKIPATHWAYS_20260410%WP428%HOMO SAPIENS Wnt signaling MYC WNT16 SENP2 PLCB2 DKK1 PPP3CA DKK2 VANGL2 SFRP4 SFRP1 SFRP2 SFRP5 CSNK2B ROR1 ROR2 CSNK2A1;CSNK2A3 CTBP2 CTBP1 NLK CXXC4 NKD1 NKD2 WNT6 WNT11 WIF1 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 FZD1 JUN WNT10B TCF7L2 WNT10A FZD3 PLCB3 TCF7L1 FZD2 CCND3 FZD5 CSNK1A1 DAAM2 WNT7B FZD7 PRICKLE2 FZD6 PRICKLE1 FZD9 GPC4 FZD8 NFATC1 WNT7A FOSL1 TPTEP2-CSNK1E;CSNK1E NOTUM RAC1 PORCN LRP5 NFATC3 LRP6 CAMK2B CAMK2D CAMK2A LEF1 INVS CAMK2G NFATC2 MAPK8 MAP3K7 PPP3CB PPP3CC RHOA ROCK2 WNT4 PPP3R1 GSK3B TCF7 VANGL1 CCND1 CTNNB1 PRKCG NFATC4 WNT3A WNT5A AXIN1 PRKCB DKK4 PRKCA APC WNT2B CHD8 FZD10 FRAT2 CCND2 MAPK9 SOX17 PLAU SOST CER1 WNT5B RYK-1 DAAM1 PLCB4 SERPINF1 CSNK2A2 CTNNBIP1 KREMEN1 PLCB1 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5393%HOMO SAPIENS Androgen biosynthesis POR HSD3B1;HSD3B2 HSD17B1 HSD17B2 HSD17B3 HSD17B4 HSD11B1 HSD11B2 SRD5A2 SULT2A1-4 CYP17A1 CYP11B1;CYP11B2 SRD5A1 AKR1D1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260410%WP727%HOMO SAPIENS Monoamine transport and regulation IL1R1 TPH2 ADORA2A CDC25C NOS1 ACHE STX1A ITGB3 SLC6A1 TH UNC13B PPP2CB;PPP2CA DBH MAPK14 IL1B AGT SYN1 SLC6A4 TSC2 SLC6A2 RBL2 SLC6A3 HRH3 SCAMP2 SLC5A7 AMPH TDO2 NECTIN2 TNFRSF11B TNF TGFB1I1 FBXO32 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260410%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL1A BLVRB IL6 BLVRA IL10RB STAT1 IL10RA STAT2 STAT3 JAK1 IL10 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence ALOX12 PTGDS LTC4S CYSLTR1 FADS1 LTA4H GGT5 PTGES2 PTGR2 DECR1 MAPK11 HPGDS PTGES3-1 ABCC4 GGT1 GSTP1 CDKN1A GPX1 PLA2G4A ALOXE3 DPEP1 AKR1B1 PTGIS FADS2 ELOVL5 ELOVL2 EPHX2 PTGES DPEP2 PTGS1 RB1 ALDH1A1 ALOX5 SLCO2A1 PRXL2B TBXAS1 SIRT1 ALOX15B SERPINE1 TP53 PTGS2-2 ALOX5AP HPGD CBR1-1 ALOX15 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260410%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors COL6A2 LAMA4 THBS2 COL3A1 COL5A1 TNXB FN1 COL4A2 COL4A1 COL6A1 LAMB2 LAMC1 THBS1 SDC2 COL5A3 COL6A3 ITGA11 COL5A2 ITGB5 COL1A2 ITGA1 ITGB6 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260410%WP4921%HOMO SAPIENS Mitochondrial complex III assembly BCS1L UQCRFS1 UQCC1 UQCR11 UQCR10 UQCC3 UQCRC1 UQCC2 UQCRC2 UQCRB TTC19 LYRM7 CYC1 UQCRQ GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260410%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3CA PLCB3 PRKD2 PRKD3 PRKD1 PRKCZ PRKCH PRKCB PPP3R1 PKN3 PRKCE PRKCD PKN1 PRKCA ANGPT2 NFATC1 PRKCI PRKCG PPP3CB PPP3CC PKN2 RCAN1 PRKCQ GNAQ PDGF PATHWAY%WIKIPATHWAYS_20260410%WP2526%HOMO SAPIENS PDGF pathway PDGFB VAV1 PIK3R1 PDGFA ELK1 RASA1 WASL ARFIP2 MAP2K2;MAP2K1 PDGFRB MAPK1 STAT1 HRAS STAT3 MAPK3 PTPN11 MAP2K4 PLA2G4A VAV2 JUN RHOA MAP3K1 GRB2 CDC42 SOS1 RAF1 CHUK SRC NFKBIA TIAM1 PLCG1 NFKB1 FOS RAC1 SRF JAK1 SHC1-1 PAK1 MAPK8 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260410%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups SARDH ARG2 GLUD1;GLUD2 CPS1 ARG1 ASL OAT NAGS PYCR1 ASS1 OTC ALDH18A1 GAMT GATM ODC1 CKB SRM SMS CKM PYCR3 ACY1;ABHD14A-ACY1 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260410%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II EPHX1 CYP2E1 GSTT2B;GSTT2 GSTM1;GSTM2-1 NNMT TPMT CYP4F3;CYP4F2;CYP4F12;CYP4F11 HNMT COMT INMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT1A1;UGT1A6 GPX4 MGST3 MGST1 MGST2 CYP46A1 GSTA3;GSTA5;GSTA1;GSTA2 CYP39A1 SULT2B1 GSR SULT2A1-4 NAA80 FMO3 GSTZ1 GSTK1 CYP2U1 GSTCD CYP2R1 GLYAT CYP4F22 CYP4X1 NAT8L CHST10 GSTA4 CYP27C1 CYP2S1 GAL3ST1 NAT9 NAT10 NAT14 AKR1B15;AKR1B10 CYP4V2 GAL3ST3 GAL3ST4 CHST8 CHST9 CYP1B1 NAA30 KCNAB1 GSTA3;GSTA1 KCNAB2 CHST11 KCNAB3 NAA40-2 CHST4 CHST2 CYP2J2-1 NAA20 BAAT NAA50-1 CYP19A1 CYP2F1 AKR1A1 CYP7B1 NAT8-2 CYP26A1 HS3ST5 CYP8B1 CYP27A1 HS3ST6 CYP1A2 HS3ST4 CYP26B1 CYP20A1 CYP1A1 AKR1B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP27B1 CYP24A1 CYP7A1 EPHX2 CYP2W1 CYP2B6 CYP2C9;CYP2C19 CYP2C18-1 CYP51A1 SULT1C3 SULT1C2 SULT6B1 SULT4A1 SULT1B1-1 FMO1 FMO2 FMO4 FMO5 CYP4B1 CYP17A1 GPX5 CHST6 CYP2D6;LOC107987479;LOC107987478-1 GSTM4 GSTM3 HS3ST3A1 HS6ST1 HS6ST2 HS2ST1 GSTO2 HS6ST3 NDST2 GSTO1 NDST1 CYP11A1 CHST12 NDST4 NDST3 GSTP1 CHST13 CHST14 UGT2A1 HS3ST3B1 GSS CHST7 HS3ST1 HS3ST2 CHST1 CHST3 CYP11B1;CYP11B2 CYP21A2 AKR7A2 AKR7A3 AKR1D1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2A13;CYP2A6;CYP2A7-1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260410%WP1455%HOMO SAPIENS Serotonin transporter activity IL1R1 IL1B STX1A TPH2 ITGB3 TGFB1I1 SLC6A4 MAOA NOS1 PPP2CB;PPP2CA SCAMP2 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260410%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS DKK1 IRF6 LMX1B VIM FAT1 NCK1 DNM1 DAG1 ITGB1 ITGB4 PCNA ITGAV WNT1 CDKN1A ITGA3 MME LAMA5 AGRN LAMB2 CTSV;CTSL SCARB2 AKT1 CD151 PTPRO TLN1 YWHAQ SYNPO TLR4 TRPC6 PARVA PAX2 CD2AP MYO1E TGFB1 INF2 NPHS1 NPHS2 MYH9 JAG1 PTK2 LRP5 LRP6 WT1 VCL CTNNB1 VTN FYN ITGB3 ILK CLDN1 MKI67 KIRREL3 CAMK2B CDKN1B KIRREL2 PLAUR KRT8 UTRN NOTCH1 LIMS4;LIMS1 CR1L;CR1 PLCE1 COL4A4 COL4A3 COL4A5 CDH2 PLCG1 PODXL ACTN4 CD80 CDKN1C SMARCAL1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260410%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A2 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260410%WP1601%HOMO SAPIENS Fluoropyrimidine activity SLC29A1 RRM1 DPYS TYMS UPB1 TYMP CES2 CES1 ABCC3 ABCC4 TDG DPYD ERCC2 UMPS DHFR2;DHFR ABCG2 SMUG1 CDA PPAT FPGS UPP1 TK1 ABCC5 GGH UCK1 SLC22A7 RRM2-1 XRCC3 MTHFR TP53 CYP2A13;CYP2A6;CYP2A7-1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260410%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC SAV1 MOB1A;MOB1B PRKAG1 PRKAG2 PRKAG3 TEAD1 TEAD2 PRKAA1 TEAD3 TEAD4 CCN1 LATS1 HMGCR LATS2 RHO STK4 RHOA PRKAA2 YAP1-1 RHOD RHOB STK3 RHOC PRKAB2 CCN2 PRKAB1 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260410%WP4521%HOMO SAPIENS Glycosylation and related congenital defects TUSC3 MAGT1 DPAGT1 B4GALT1 ALG8 ALG9 MPI SRD5A3 ALG2 ALG14 ALG3 PMM2 MOGS ALG12 ALG1 DOLK ALG11 DPM1 GMPPB ALG6 DPM2 DPM3 MPDU1 MGAT2 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260410%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC4 ELP3 KAT2B ALDH1A3 HAT1 CYP2E1 MAT1A HDAC2 HDAC1 TYMS HDAC8 MTR-1 HDAC10 ALDH1A2 DHFR2;DHFR ACSS2 ALDH2 AHCY ATF2 HDAC6 ADH1C;ADH1B;ADH1A HDAC3 HDAC7 ALDH1A1 SLC19A1 HDAC5 MTHFR HDAC9 EHMT2 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB2 S1PR3 S1PR1 S1PR2 S1PR5 AKT3 MAPK1 SPHK2 SPHK1 AKT2 MAPK4 MAPK3 ASAH1 MAPK12 PIK3C2B PLCB3 MAPK7 SMPD2 GNAI3 AKT1 GNAI1 GNAI2 RACGAP1 MAPK6 PLCB1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260410%WP4595%HOMO SAPIENS Urea cycle and associated pathways FH MDH2 NOS2 SLC25A15 GLUD1;GLUD2 CPS1 GLS2 ARG1 GPT ALDH4A1 ASL OAT NOS3 NAGS PYCR1 ASS1 NOS1 OTC SLC25A13 GOT1-1 GOT2-1 MDH1 LDHB SLC25A12 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260410%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 SMAD4 CREB1 FBL DDX21 MAFG CLOCK IRF2 ALX1 POLR1E CREBBP PCNA FOXO1-1 ARNTL NCOA3 NPAS2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP3K8 DUSP1 MAP3K21 MAP3K7 MAP3K10 ATF4 PARP1 MAPK11 ARAF MAP3K11 MAP2K2;MAP2K1 MAPK1 MAP2K7 MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP3K1 BRAF MAPK14 MAPK12 MAPK10 MAPK13 RAF1 MAP3K12 MAP3K9 MAP3K5 MAPK9 PARP14 TNKS MAPK8 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases MDH2 D2HGDH IDH2 ALDH7A1 GCDH ADHFE1 L2HGDH ACY1;ABHD14A-ACY1 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260410%WP5031%HOMO SAPIENS Biotin metabolism including IMDs MCCC1 PCCB ACACB ACACA PC MCCC2 BTD PCCA HLCS HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260410%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260410%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling GPAM IDI1 FDPS CYP51A1 LSS SQLE SREBF1 PRKAA1 RBP4 MVD PPARGC1B SAR1A INSIG2 HMGCR MED15 RNF139 FDFT1 SREBF2 SCAP HMGCS1-1 INS;INS-IGF2 SEC23B SEC31B SCD SEC31A FASN SEC24B AMFR NFYA-1 PPARG SEC24D-1 SEC24C MBTPS1 PRKAA2 ACACA ACLY INSIG1 ATF6 MBTPS2 CDK8 SP1 AKT1 NR1H2 PRKACA-1 SEC13 SIRT1 SCARB1 PRKAB2 SEC23A PRKAB1 LDLR KPNB1 CREB1 PRKAG1 LPL PRKAG2 PRKAG3 FGF21 LPIN1 SEC24A MTOR SAR1B CAMP YY1 GSK3A ACSS1 MDH1 PIK3CA CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260410%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism XDH CYP2A13;CYP2A6;CYP2A7-1 CYP1A2 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260410%WP2290%HOMO SAPIENS RalA downstream regulated genes NRAS EXOC8 RAC3 CDC42 RALBP1-1 KRAS HRAS RAC1 EXOC2 RALA-1 YBX3 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer LDLR BCAT2 GFPT1 PGM3 HK2 GLUD1;GLUD2 RPIA HK1 HMGCS2 RPE;RPEL1 GPT CARM1 SOAT1 GOT1-1 BCKDHA PDHA1 HMGCR SLC7A5 ME1 FASN LDHA SLC43A1 PKM SLC16A4 SLC16A1 SLC2A1 PDHX GLS2 ACLY KRAS CS UAP1 GNPNAT1 DLD GOT2-1 SLC1A5 MDH1 PFKL TP53 DLAT GPI PDHB NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260410%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway CASP8 DUOX2 IL18 PYCARD NAIP COPS6 CASP5;CASP4 CASP1 RIPK2 HSP90AA1 NOD1 NDUFA13 NLRC4 IL1B MEFV NLRP7;NLRP2 NLRP4 NLRP1 PRDM1 AAMP CHUK CARD9 CARD6 ACAP1 AIM2 NOD2 NLRP10 IKBKB NFKBIA SUGT1 ERBIN IKBKG RELA RAC1 NLRP3 CASP9 NLRP12 CASP7 XIAP NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260410%WP5572%HOMO SAPIENS Nucleosome remodeling complex IPO4 NASP-1 CHEK2 SUPT16H HAT1 ASF1A H4-16 NAP1L1 RBBP4 SSRP1 H4C1 H4C6 XRCC6 DAXX CHAF1A MCM2 XRCC5 CHAF1B ASF1B PCNA PRKDC SMIM40 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP560%HOMO SAPIENS TGF beta receptor signaling RUNX3 SMAD2;SMAD3 FKBP1A ZNF423 SMAD1 HRAS MAPK3 SMAD9 ZEB2 WNT1 SMAD5 SKI JUN LIF BMP4 LTBP1 SKIL ENG SMAD7 EGF FOXH1 ZFYVE9 NFKB1 BAMBI FOS SERPINE1 JAK1 NOG TGFB1 SMAD6 FST CREBBP CTNNB1 THBS1 TFE3 EP300 STAT1 STAT3 RUNX2 ITGB6 TGFBR1-1 IFNG SMAD4 TGFBR2 LEF1 INHBA TGFBR3 MAPK9 TNF LEFTY2;LEFTY1 TGIF1-1 SPP1 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2064%HOMO SAPIENS Neural crest differentiation MYC AXIN2 FGF19 FGFR1 HDAC2 HDAC1 CTBP2 MPZ MSX2 TBX6 PMP22 MBP HDAC10 PHOX2B DVL1 DVL2 DVL3 RBPJ WNT1 TFAP2A GBX2 FZD3 MSX1 TCF7L1 BMP4 DLX5 SNAI1 FGFR3 LHX2 ID1 ASCL1 HDAC9 ETS1 PAX7 MYB FGF2 CDH7 NOTCH1 CDH6 SNAI2 DLL1 DLL3 DLL4 HES1 FGF8 HDAC3 HES5 HAND1 CDH2 COL2A1 GJB1 ZIC1 ITGB1 SMAD1 BMP7 HOXA1 GFAP ISL1 CDH1 NFKB1 HDAC11 MIA SOX10 HOXB1 LHX5 DMBX1 FOXD3 OLIG3 OLIG1 DCT OLIG2 PRTG SOX9 NEUROG1 HDAC4 LHX1 GSK3B HEY2 CTNNB1 FGFR2 HDAC8 TFAP2E;TFAP2B SOX5 PAX3 WNT8A WNT3A AXIN1 TCF4 HDAC6 MITF RHOB NOTCH2 NOTCH3 HDAC7 NOTCH4 HDAC5 TLX2 COL11A2 NFKB2 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260410%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NPC1L1 CD36 NR1I2 SCARB1 VDR CYP2C9;CYP2C19 PPARD PPARA INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TGFB1 TGFB3 PDCD1 CXCL10 IL4R TLR8 TLR7 IL2RG SOCS1 IL2RA IL4 IL2RB STAT3 STAT6 CCL5 TGFBR2 IRAK4 TRAF6 CTLA4 NFKB1 TLR4 CD86 CD80 PIAS3 NFKB2 CD274 CCL13;CCL2 TGFB2 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260410%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism FFAR2 FFAR3;GPR42 SLC2A4 GCG PPARD PYY RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260410%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCD3 PLCD4 PLCB2 PLCD1 IL6 AKT3 MAPK1 AKT2 MAPK3 IL12B IL12A PIK3CB PIK3CG MAPK14 RETN PLCB3 ITPR1 PLCG2 CHUK PLCE1 CXCL8 IKBKB NFKBIA PIK3CD AKT1 PLCG1 IKBKG RELA NFKB1 TNF PLCB4 PIK3CA PLCB1 AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260410%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension HAL UROC1 AMDHD1 GPT2 GLUD1;GLUD2 FTCD FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260410%WP143%HOMO SAPIENS Fatty acid beta oxidation ECHS1 ACSL1 CRAT TPI1 ACADL GK ACSL6 ECI1 ACAT1 ACSL5 GCDH ACSL3 GPD2 LPL DECR1 LIPE GK2 LIPF ACADVL PNPLA2 HADHB-1 ACSS2 CPT2 ACADS ACADM ACSL4 HADH LIPC CHKB DLD HADHA CPT1B SLC25A20 CPT1A IL4 SIGNALING%WIKIPATHWAYS_20260410%WP395%HOMO SAPIENS IL4 signaling CEBPA CEBPB BAD IL2RG ELK1 MAPK1 MAPK3 MAPK14 GRB2 SOS1 CHUK FES ATF2 IRS1 IKBKB NFKBIA PIK3CD AKT1 IRS2 NFKB1 FOS JAK1 GAB2 TYK2 FLNA SOCS5 IL4R PIK3R2 PIK3R1 CBL SOCS3 MAPK11 SOCS1 EP300 STAT5A STAT1 IL4 STAT3 PTPN11 RPS6KB1 STAT6 PTPN6 JAK2 JAK3 INPP5D RELA DOK2 STAT5B SHC1-1 PIK3CA PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5103%HOMO SAPIENS Progeria associated lipodystrophy TGFB1 SMAD2;SMAD3 SMAD4 FFAR3;GPR42 LMNA MUCL3 SPRTN FBN1 RECQL WRN PARP1 POLD1 ZMPSTE24 LMNB2 INS;INS-IGF2 FNTA LMNB1 BANF1 ICMT KCNJ6 PPARG ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260410%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis PTGS1 TBXA2R GNA13 TBXAS1 GNA12 ARHGEF1 RHOA CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260410%WP4191%HOMO SAPIENS Caloric restriction and aging AKT1 PPARGC1A IGF1 SIRT1 PRKAB2 NAMPT TP53 MTOR JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260410%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells IL6 IL6R SOCS3 CDK4 GHR SOCS1 AKT3 SOCS2 NRAS IFNGR1 IFNGR2 EPO STAT5A FOXM1 STAT1 AKT2 HRAS PRLR AKT1S1 STAT3 CISH MTOR IFNG JAK2 CCND3 KRAS PRL AKT1 EPOR CCND2 RPTOR MLST8 STAT5B ARYLAMINE METABOLISM%WIKIPATHWAYS_20260410%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A2 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260410%WP185%HOMO SAPIENS Integrin mediated cell adhesion CAV1 CAPNS1 ARAF MAP2K2;MAP2K1 MAPK1 HRAS MAPK4 MAP2K6 MAP2K3 BRAF CAPN1 MAPK12 MAPK10 GRB2 SELENOP MAPK7 SOS1 RAF1 PDPK1 CAPN10 AKT1 RAC3 ITGAD ITGAM RAP1B RAC1 RAPGEF1 CRK PIK3R2 RAP1A FYN ITGB3 ITGA2B SHC3 PAK1 MAP2K5 ARHGEF7 PAK2 ITGB1 ITGB4 ITGB2 ITGAV VAV3 ITGA4 ITGA3 VAV2 ITGA2 ITGA1 ITGA6 ROCK2 ROCK1 CDC42 TLN1 CSK VASP BCAR1 ZYX MYLK2 PTK2 CAPN9 CAPN6 CAPN7 CAPN5 CAPN2 TNS1 MYPN AKT3 VCL GIT2 CAPN11 CAV3 CAPN3 ITGA10 RHO AKT2 ITGA11 ITGB5 PAK3 ILK ITGB8 ITGB7 PAK4 ITGB6 ITGA8 ITGA7 ITGA5 BUB1B-PAK6;PAK6 DOCK1 ITGA9 SRC PXN MAPK6 SORBS1 ITGAE ITGAL SHC1-1 CAV2 ITGAX ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260410%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease CREB1 CASP3 BDNF RAF1 NTRK2 EGF HTT EGFR ELK1 MAP2K2;MAP2K1 GRM1 MAPK1 RPS6KA5 HRAS MAPK3 CASP7 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260410%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2;SMAD3 SMAD4 VIM TNC FN1 CDH6 SNAI2 SNAI1 AKT3 AKT1 CDH2 CDH1 MAPK1 AKT2 ID1 MAPK3 RUNX2 CDH16 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260410%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer TELO2 MAPKAP1 PIK3R1 PARP1 ARAF AKT3 NRAS MAP2K2;MAP2K1 EIF4EBP1 AR MAPK1 AKT2 HRAS AKT1S1 MAPK3 MTOR RPS6KB1 PTEN BRAF PDK1 PRR5L GRB2 KRAS SOS1 TSC2 RAF1 SOS2 IRS1 DEPTOR AKT1 TSC1 RPTOR RICTOR MLST8 INPP4B PARP2 PIK3CA SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260410%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias RUNX3 FGFR1 PTCH1 IHH PLAT GLI3 ADAMTS1 HMGCS1-1 BMP7 MMP9 THRA SLC38A2 PTH1R MMP13 PTHLH IGF1R FGF18 FGFR3 CTSV;CTSL AKT1 ALPL PRKACA-1 SOX9 TGFB2 HDAC4 TGFB1 IGF2 IGF1 ADAMTS4 GHR ADAMTS5 COL10A1 TIMP3 SOX6 NKX3-2 CHST11 SOX5 DDR2 STAT1 BMPR1A CAB39 SCIN SERPINH1 BMP6 RUNX2 MGP ENPP1 FGF2 KIF3A ACAN MEF2C COL2A1 PLAU CALM1 PTH FRZB STAT5B IFT88 VEGFA CDKN1C SPP1 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260410%WP2113%HOMO SAPIENS Type III interferon signaling IFNLR1 IL10RB STAT1 STAT2 IRF9 JAK1 IFNL2;IFNL3;IFNL1 TYK2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260410%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis KLF5 CEBPA CEBPB CEBPG GATA2 SREBF1 CEBPD GATA3 EGR2 DDIT3 PPARG KLF15 KLF2 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260410%WP5574%HOMO SAPIENS Oligodendrocyte development MAG MYRF NKX2-2 CHD7 SOX6 PTN ZNF24 GLI2 MBP SOX5 SMAD1 DUSP15 SHH ZNF488 NFIA LGI1 NKX2-6 OPALIN ZBTB33 ZEB2 CSPG4 TMEM98 SOX11 CNTN1 BMP1 FGF2 TCF7L2 MYT1 WNT10A BMP4 PTPRZ1 PDGFRA PRKCA HES5 CHD8 NFATC2 ID2-1 SOX10 ID4 NKX6-1 ASCL1 SOX2 EGR2 OLIG1 SOX8 OLIG2 SOX9 RELN MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260410%WP2001%HOMO SAPIENS miR targeted genes in adipocytes PHC2 FADS1 ELOVL5 IGF2R CEBPB TGFBR2 SRSF9 LPL CYP1B1 PICALM TMED10 HIPK3 TMEM43 CSRP1 SRSF10 CAP1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260410%WP45%HOMO SAPIENS G1 to S cell cycle control MYC E2F1 CDKN2B ORC5 CDK7 ORC4 CDC25A ORC6 ORC3 ORC2 MCM2 E2F2 CDK4 E2F3 CDK1 PCNA CDKN2D POLE CDC45 RPA3 CDKN1A RPA1 RPA2 MYT1 CCND3 CCNG2 POLE2 GADD45A ATF6B CDK6 CCNE1 TP53 MDM2-2 CREB1 CDK2 CCNE2 CCND1 CREB3L1 CDKN2C MCM7 WEE1 ATM PRIM2 MCM3 CDKN2A MNAT1 CCNA1 MCM4 CCNB1 MCM5 POLA2 MCM6 CDKN1B TFDP1 TFDP2 ORC1 CREB3L3 RB1 CREB3L4 CCND2 PRIM1 CCNH CDKN1C CREB3 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5406%HOMO SAPIENS 13q12 12 copy number variation TRAF1 FLNC TRAF5 DAG1 MAG RTN4R SGCA RTN4 ADIPOQ RHOA TRAF2 MIPEP C1QTNF9B;C1QTNF9 DTNA ATXN1 SGCD SNTB1 SGCB SACS SGCG CDC42 TNFRSF19 DMD SPATA13 SNTA1 LINGO1 SSPN TRAF3 MAPK9 RAC1 MAPK8 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260410%WP3945%HOMO SAPIENS TYROBP causal network in microglia RUNX3 CD4 ITGB2 C3-1 GPX1 ZFP36L2 RPS6KA1 PLEK MAF ITGAM NCF2 SLC1A5 TNFRSF1B TYROBP IL18 C1QC PYCARD HCLS1 IL10RA GAL3ST4 CAPG NPC2 ABCC4 DPYD STAT5A LYL1 SH2B3 SLC7A7 TGFBR1-1 CD84 NRROS FKBP15 IL13RA1 LOXL3 TCIRG1 CD37 RNASE6 APBB1IP BIN2 NCKAP1L ELF4 RGS1 CREB3L2 SFT2D2 TMEM106A RBM47 LGALS9C;LGALS9;LGALS9B IGSF6 KCNE3 SAMSN1 ADAP2 HLX CYTL1 PPP1R18;LOC107987457 ITGAX LHFPL2 GAPT SPP1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260410%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC4 HEXIM1 SUPT5H PPP3CA PPP3R1 HDAC2 CREBBP HDAC1 NFATC3 HDAC8 EP300 PPP3CB PPP3CC CCNT1 NFATC4 CDK9 NFATC1 HDAC3 NFKBIA SP1 HDAC7 RELA NFKB1 HDAC5 NFATC2 HDAC9 NELFB NELFCD NELFA NELFE SUPT4H1-1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5153%HOMO SAPIENS N glycan biosynthesis B4GALT3 MGAT4A-1 MAN1A2 GMPPA TUSC3 MAN1A1 ST6GAL1 ST6GAL2 ALG5 DAD1 MAN1B1 GANAB MAN2A2 MAN2A1 MGAT5 MAN1C1 MGAT3 MGAT5B-1 MGAT4C MGAT4D DOLPP1 MGAT4B STT3A RPN2 STT3B ALG10;ALG10B RPN1 ALG6 MPDU1 DDOST FUT8 PMM2 ALG1 DPM2 RFT1 B4GALT2 B4GALT1 MGAT1 DPAGT1 ALG8 ALG9 MPI SRD5A3 ALG2 ALG14 ALG3 MOGS ALG12 DOLK ALG11 DPM1 GMPPB GPI DPM3 MGAT2 LAC PHE PATHWAY%WIKIPATHWAYS_20260410%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260410%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer SYTL4 UNC13D SYTL3 SYTL2 RPH3A TBC1D10A EXPH5 MLPH MADD RPH3AL SYTL1 GCC2 MYRIP RAB27A RAB27B SYTL5 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260410%WP455%HOMO SAPIENS GPCRs class A rhodopsin like FPR2 LTB4R CYSLTR1 CYSLTR2 GPR35 C3AR1 NPFFR2 RRH GPR174 GPR173 GPR171 GPR37L1 OR7A10;OR7A17-11 OR2AG1;OR2AG2 OR1I1 NPBWR1 OPRK1 NPBWR2 OR6B1 GPR12 HCAR2;HCAR3 OR6A2 GPR19 GPR27 GPR25 PTGDR2 GPR21 GPR22 GPR20 OR10H1;OR10H5;OR10H2 FFAR1 GPR39 GPR37 GPR34 GPR32 OR1A1-1 OR2S2-1 OR3A2 GPR45 PTAFR CHML GPR52 GPR1 OR8D2-1 GPR50 GPR4 GPR3 GPR6 F2RL1 OR1C1 GPR65 GPR63 CCRL2 OR2D2 GPR75 OR2T1 APLNR OR5V1-2 OR2C1 SUCNR1 OR5I1 GPR87 MCHR1 OR1Q1 HCAR1 OR2B3 OR2J1;OR2J2;OR2J3-2 NMUR2 NMUR1 OR14J1 FFAR3;GPR42 MLNR OR7C1;OR7C2-9 PRLHR OR2H2 OR10A4 CNR2 OR8B8 OR2W1 OR12D3 OR1D2 OR10J1-2 ACKR4 ACKR2 OR11A1 F2RL2 GPR85 CCR10 CCR1 XCR1 CCR9 CCR8 CCR7 CCR6 CCR4 MAS1 CCR3 CCR2 CX3CR1 CXCR5 CXCR3 CXCR2 AGTR1 ADORA2A ADRA1D ADRA1B ADRA1A DRD2 DRD3 FSHR DRD4 TBXA2R PTGIR CNR1 F2R ADRB2 CXCR1 CHRM2 NPY4R2;NPY4R BRS3 MC4R CCKAR GHSR LHCGR NPY5R AVPR1B NPY1R OPRM1 GRPR AVPR1A SSTR3 HTR1A SSTR4 TRHR SSTR5 OPRD1 FPR1 MC2R GALR3 OR2B6;OR2B2-1 GALR2 EDNRA GALR1 EDNRB NTSR2 NMBR MC1R MC5R OR1F1 OR2H1-1 CMKLR1 HTR2A LPAR4 OR1E1;OR1E2 OR3A1 OR10A5 PTGFR LPAR5 LPAR6 C5AR2 HRH3 SSTR1 SSTR2 OR2A7;LOC107987545;OR2A4 GPR83 NTSR1 GPR17 PTGER4 PTGER1 P2RY13 PTGER2 P2RY11 PTGER3 OR2F1-2 AGTR2 GPR18 F2RL3 MTNR1A CCR5 BDKRB2 GPR15 BDKRB1 CXCR4 AVPR2 MC3R OPN4 OPN3 GPR161 OPRL1 NPFFR1 ACKR3-2 CHRM3 HTR4 CHRM1 HTR6 CHRM4 HTR7 CHRM5 GPR68 HTR2B ADRB1 HRH1 HRH2 DRD5 HTR1E HTR1F HTR1D HTR1B HTR5A OXTR ADRA2C NPY2R ADRA2B ADRA2A ADRB3 ADORA1 DRD1 P2RY6 PTGDR FFAR2 P2RY12 P2RY4 P2RY2 HCRTR2 ADORA3 P2RY1 HCRTR1 MTNR1B ADORA2B P2RY10 P2RY14 GPER1 OPN1SW OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RHO CCKBR NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EVI2B SUPT5H CRLF3 EZH1 EIF3A CRY1 METAP2 MCL1 PER1 EED ARF6 PCNA MAPK1 LIMK1 RAD51 BCL2 RFC5 MAPK3 MAP3K2 RFC3 RFC4 RHOA MAP3K1 EXOC8 NGF RFC2 MYT1 ROCK2 ATR H4-16 EXOC4 RAD9A EXOC3 EXOC6 HOXA1 EXOC5 H4C1 SOS1 H4C6 RAF1 EXOC2 IFNB1-4 EXOC1 EGF TUBB4A;TUBB;TUBB8B;TUBB8 POLRMT SDC2 CCNE1 PRMT5 NGFR H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCNE2 OMG EGFR CCNA2-1 RTN4R USP1 JARID2 SUZ12 NF1 DDX58 SYN1 MAVS RBBP7 CFL1 WDR48 HOXA9 EVL EXOC7 ATAD5-1 RNF135 INPP5A ADAP2 RAB11A E2F6 RAB11FIP4 TEFM DNMT1 UTP6 COPRS EVI2A NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260410%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging SIRT3 HIF1A NFKB1 FOXO1-1 TFAM-1 SIRT1 NAMPT FOXO3 ROS1 PARP1 PPARG CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260410%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction IL27RA IL21R IL17F TNFRSF14 IL17A IL17RC IL17RA TNFSF4 GDF15 IL25 PRL EDA TNFRSF13C EDA2R IL17D IFNAR2 IL17C IL17B IL18 IFNAR1 MSTN IL18RAP CCL1 IL18R1 TNFSF13B LTB ACVR1 CD40LG INHBA CXCL13 CXCL14 IL9 IL9R PF4;PF4V1-1 ACKR4 ACVR2B CCL3L1;CCL3L3;CCL3;CCL18 ACVR2A FASLG TNF CD40 TNFRSF13B BMP8B CCR10 CCR1 XCR1 IL20RA XCL1;XCL2 IL20RB PPBP TNFSF14 LTBR TNFSF10 TNFSF15 CXCL11 GDF2 GDF1 GDF6 IL22RA1 CD27 TNFRSF12A IL17RB CXCL9 CNTF RELT CX3CL1 CD70 IL1A CLCF1 CCL23;CCL15 INHA IL1R2 CCR9 MPL CCR8 TNFRSF8 CCR7 IL13RA2 CCR6 EDAR CCR4 FAS TNFRSF17 CCR3 TNFRSF9 CCR2 INHBC INHBE TNFRSF21 ACVR1C CX3CR1 CCL11 LIF CXCR5 NFIC CXCR6 CXCL17 INHBB IL36A IL36B IL36RN TSLP CXCR2 IL36G IL1F10 IL31RA IL20 CCL19 TNFRSF1A IL26 IL1RL1 IL24 CCL25 IL19 CCL24 CCL22 IFNK CCL14 CCL21 AMHR2 TNFRSF1B CCL20 LTA IL1RN IFNL2;IFNL3;IFNL1 CCL28 CCL27 IL1RAP IL33 IL31 CCL26 IL37 TGFB2 TGFB1 GDF3 TGFB3 IL1R1 AMH IL10RB IL10RA NODAL IFNGR1 IFNGR2 BMP15-1 GDF9 TGFBR1-1 IL12RB1 IL12RB2 CSF3R TGFBR2 IL5RA IL13RA1 CXCR1 TNFRSF11B TNFSF11 CCL8 BMP5 IL3RA TNFRSF25 BMPR2 IL2RG IL2RA IL2RB IL23A BMP4 GDF7 BMPR1B CXCL8 GDF11 IL15 IL13 CCL13;CCL2 IL6 NGFR IL6R IL4R CSF2RB CSF2RA CSF3 CSF2 CNTFR CSF1 TNFRSF11A CCR5 CXCL2;CXCL3;CXCL1-1 EPO IL2 IL4 PRLR IL7 IL7R CCL4L2;CCL4L1;CCL4 BMP3 IFNG ANP32B GDF10 CXCR4 ACVR1B TPO EPOR IL3 IL5 CSF1R IL11 CXCL10 CXCL12 BMP7 LEP NGF CCL5 TNFSF9 BMP10 IFNB1-4 ACKR3-2 IL1RL2 CXCL5;CXCL6 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A IL10 GDF5 GHR IFNLR1 BMPR1A ACVRL1 BMP6 IL34 TNFRSF19 LIFR IL6ST TNFRSF4 TNFRSF18 IL11RA LEPR IL21 IL22 IL23R IL27 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260410%WP4249%HOMO SAPIENS Hedgehog signaling LRP2 SMURF1 EVC CCND1 PTCH1 PTCH2 IHH BOC GPR161 KIF7 GLI1 ARRB1 GLI3 ARRB2 GLI2 SHH CSNK1D GRK2 BCL2 GAS1 HHIP SMO CDON GRK3 SPOP CSNK1G3 SMURF2 FBXL17 KIF3A SPOPL CSNK1G2 CSNK1G1 EVC2 CSNK1A1 PRKACB-1 PRKACA-1 TPTEP2-CSNK1E;CSNK1E CCND2 DHH CUL3 HUNGER AND SATIETY%WIKIPATHWAYS_20260410%WP5445%HOMO SAPIENS Hunger and satiety POMC AGRP GCG MC4R GHRL NPY LEP PYY VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260410%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling PPP3CA DECR1 ELK1 MAP2K2;MAP2K1 MAPK1 MAP2K7 HRAS AKT1S1 MAP2K6 FGB MAPK3 FGA MAP2K3 MAP2K4 GPX1 ADAM10 JUN GPC1 FGG MAPK14 MAPK12 PLCB3 EIF2A NAP1L1 GRB2 MKNK1 RAF1 TXN HBD;HBB PRDX2 TRPC3 LDB2 RPS6KA5 RACK1 MLST8 RAC1 ALB RPS6 CREB1 MYH9 RAPGEF1 CRK TFAM-1 MAPKAP1 SHB PIK3R2 PRKG1 PIK3R1 BMX CBL RAP1A NR4A3 TAL1 FYN EIF4E STAT1 STAT3 NR4A1 PTPN11 MTOR RPS6KB1 ANXA1 PTPN6 IDH2 PTPRZ1 FHOD1 SARS1 SLC8A1 FAF1 HSPB1 FLII FSCN1 SHC2 NOX4 ACTG1 ERN1 FOXO3 CYCS-1 PAK1 CLTC MAPK8 PGD GLUD1;GLUD2 FADD PAK2 ATF4 LIMK1 MAPKAPK2 BCL2 FAS VAV2 FUT1 MMP10 ROCK2 BCL2L1 HSPA1A;HSPA1B NFKB1 CSK BCAR1 HDAC4 FLNB PPP1CA JAG1 CAPN2 CTNNB1 VCL TKT ITGB5 FRS2 STAT6 IGFBP7 INPP5K EPHB2 PLCG1 NOTCH4 OCRL ABL1 INPP4B PIK3CA PFN1 ELOC-1 BIRC5 MYH11 HDAC1 TRPC1 CNP PPP2CB;PPP2CA BMP2 ATF2 CXCL8 ICAM1 AKT1 MAP3K5 FOXO1-1 RCAN1 PTGS2-2 HERPUD1 MDM2-2 SOD2 ETS1 QKI CREBBP DNAJA1-1 EIF4G2 ITGB3 PLAUR TNXB DLL4 GATA2 FBXW11 EGR3 NFATC2 CALR-1 ARF4-1 DPM1 VPS39 LDHA TPP1 TBCA ENG ACKR3-2 NFKBIA ELOA CSRP1 SH3BGRL3 ADAM9 ERG PNP-1 MYO1C ATP6V1E1 PRKCB PRKCE PRKCD GJA1 PRKCA CFL1 GRB10 SRC PXN RELA MEF2C MAPK9 PRKCI PTK2B RICTOR EGR1 HGS VEGFA HLX IQGAP1 SHC1-1 CAV1 STAM SYNJ1 RAB5A AP2A1 NCK1 GAB1 EPN1 ARF6 PRKAA1 AP2S1 EPS15 ITCH TUBA1C ACACB ACACA PDPK1 ACOT9 NFATC1 TUBB4A;TUBB;TUBB8B;TUBB8 EPB41 NCF2 RAP1B CYBB CCRL2 HSP90AA1 ARNT IGFBP3 CSRP2 TMOD1 TPM3 CCT7 RHOC TAOK2 MYL2 NUMB RPL10A RPL7 MAPKAPK5 NCF1 RPL18A RPLP2 MMP2 PLA2G4A RPS11 RHOA MMP14 EZR EIF2AK3 ROCK1 FOXO4 WASF1-1 PRKCZ ARPC5L CDC42 LUC7L IER5 NOS3 SND1 EWSR1 BIN1 ATF6 GIGYF2 RPL13A-1 MYO6 RPL27 PRRC2C RPL26 TRIP4 LARP7 PRDX6 GIPC1 HYOU1 FARSB KCNC3 SRP54 EEA1 CGNL1 SSR4 SSR3 KANK1 CAMKK2 SLC7A1 PABPC1;PABPC3 APOLD1 LMAN1 SIAH2 FGD5 CTNND1 PLOD3 TMSB10 SEMA6D RPL5-1 ARMCX1 RAB37 DSC1 LRRC59 STIP1 TXNDC5 GSK3B KL SDF2L1 TFCP2 CCND1 RCAN2 SPIRE1 NRARP CAPZB ACP1 ADAMTS9 ARRB2 SLC25A11 PBXIP1 PPM1G SET-1 DNAJB4 DUSP5 SLC25A25 CDC42BPB PTPN14 TPCN2 EIF3H PTPN9 EIF3F P4HB EIF3D TRAF3IP2 UBAP2L CHAC1 TMEM170A KATNAL2 F3 ASCC3 ZNF555;ZNF57;ZNF556 ATP6V0D1 DHX36 MICAL2 SRPK1 EPRS1 CALU DHX29 CCDC124 PLA2G5 CLIC1 BRD4 FJX1 ADRB2 NAPA NEXN CRIP2 PRKRA PLAU COPG1 TMOD3 DOK1 BSG HTRA1 SCUBE2 CACNA2D1 ZC3H15 NR4A2 AFDN GRSF1 C15orf39 RND1 LRRFIP2 ABCF2-H2BE1;ABCF2 ARHGEF15 DKK1 SHROOM2 RCN1 USP10 FAM120A TNFRSF25 RBM39 MOV10 PDE4DIP FMNL3 GAPDH-1 PGK1 ALDOA YWHAE NCL-1 P4HA2 SMARCA2 HDAC9 CCL13;CCL2 FN1 MMRN2 TEAD4 FHL2 CCN1 HBEGF FXR2 HMGB1-1 PTPRJ CDH5 PTMA TXNIP PGF RAB11A PSMD4 SDCBP EIF4G1 ITGB1 NRP2 FLT1 ADAMTS1 PSMD11 ITGAV OCLN-1 PRKAA2 BMP10 KDR CCN2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A EPHA2 PTK2 S1PR1 DNAJB9 PDIA6 CTNNA1 PBK PRKD2 PRKD1 RAB4A AMOT RHOJ HDAC7 NDRG1 HDAC5 PTPN1 SRF SELE CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260410%WP4918%HOMO SAPIENS Cellular proteostasis PFDN4-1 VBP1 PFDN1 PFDN2 PFDN5 PFDN6 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260410%WP4220%HOMO SAPIENS Neurotransmitter disorders DBH PNMT TPH2 DDC TPH1 TH MAOA COMT SLC18A2 SLC6A3 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260410%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK2 SLC2A1 GLP1R PCSK1 GCG INS;INS-IGF2 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260410%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia MYC AXIN2 RARA DKK1 JUP GSK3B LRP5 LRP6 CCND1 CTNNB1 SALL4 PYGO1 FLT3 PML BCL9 WIF1 PPARD WNT1 RUNX1T1 CSNK1A1 LEF1 FZD6 APC AKT1 ZBTB16 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260410%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPL PDXK PNPO PLPBP ALPG;ALPP;ALPI-1 ALDH7A1 PIGV EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260410%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGDR PTGDS PTGR1-1 EHHADH-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 ACOX3 JMJD7-PLA2G4B;PLA2G4B PPARD PLA2G4A PPARG ACOX2 AKR1B1 PTGIS TBXA2R PTGIR ACOX1 ACAA1-1 PTGFR PTGES PLA2G5 PLA2G6 PTGS1 PRXL2B TBXAS1 PTGDR2 PTGS2-2 HPGD GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260410%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation MYC CRTC2 IGF1 CDK2 PDGFA CDK4 AKT3 FLT1 MAPK1 FOXM1 AKT2 INS;INS-IGF2 MAPK3 DLK1 TGFBR1-1 BRAF IGF1R KRAS SMAD7 INSR AKT1 RASSF1 FOXO1-1 PDX1 PGF SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260410%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder HOMER1 DLG4 BDNF SHANK3 NRAS PRKAA1 MAPK1 ARC HRAS MAPK3 PRKAA2 GRIN2C GRIN2B CACNA1C GRIN2D KRAS GRIN3B NTRK2 GRIN3A PIK3CD AKT1 GRM1 TSC1 RPTOR CAMK4 PRKAB2 PRKAB1 RHEB GRIN1 GSK3B PIK3R2 PRKAG1 PIK3R1 PRKAG2 PRKAG3 AKT3 EIF4EBP1 AKT2 MTOR RPS6KB1 PTEN PIK3CB NF1 CAMK2B TSC2 PIK3R3 UBE3A GRIN2A PIK3CA SYNGAP1 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260410%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells CYP2B6 AOX1 CYP2A13;CYP2A6;CYP2A7-1 FMO3 APOPTOSIS%WIKIPATHWAYS_20260410%WP254%HOMO SAPIENS Apoptosis CASP8 MYC TP63 CASP10 TRAF1 CASP6 HRK CASP3 IRF6 MCL1 IRF2 BIRC5 FADD TNFRSF25 TNFSF10 BAD BIRC2 BOK DFFB BIRC3 DFFA TRADD CASP5;CASP4 NFKBIB APAF1 CASP1 CFLAR BCL2 BNIP3L FAS HELLS SCAF11 MAP2K4 TNFRSF21 JUN TP73 TRAF2 MAP3K1 PRF1 DIABLO-1 MAPK10 IGF1R BAK1 CHUK BAX IKBKB NFKBIA AKT1 IRF3 IKBKG TRAF3 BCL2L1 IRF7 NFKB1 TNFRSF1A CASP2 RIPK1 BID TNFRSF1B LTA TP53 MDM2-2 XIAP GZMH;GZMB-1 IRF4 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A IGF2 IGF1 PIK3R1 PMAIP1 BCL2L2 IRF1 NFKBIE CDKN2A CRADD IRF5 RELA FASLG BCL2L11 TNF CASP9 CYCS-1 CASP7 BBC3 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260410%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure HSD3B1;HSD3B2 MAPK10 CASP3 CYP11A1 PARP2 BAX PRDX2 STAR FOLATE METABOLISM%WIKIPATHWAYS_20260410%WP176%HOMO SAPIENS Folate metabolism MPO MAT1A MTHFD2 SERPINA3 PLAT MTR-1 SAA2;SAA1 CBS;CBSL INS;INS-IGF2 SHMT2 FGB SHMT1 FGA SAA2-SAA4;SAA4 IZUMO1R GPX1 FOLR2 GPX4 GPX6 FGG F7 PLG INSR HBD;HBB SOD1 ICAM1 CRP NFKB1 MTHFR SCARB1 SERPINE1 CAT SOD3 TP53 HBA2;HBA1 CTH ALB CCL13;CCL2 APOB LDLR ABCA1 SOD2 IL6 MTRR CSF1 IL2 F2 IL4 DHFR2;DHFR IFNG IL1B AHCY ST20-MTHFS;MTHFS SLC46A1 FLAD1 RFK MTHFD1 FOLR1 GART RELA SLC19A1 APOA1 TNF NFKB2 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260410%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis CASP8 TNFRSF1A FTL-1 FADD RIPK1 TNF RIPK3 PLA2G4A PARP1 TRADD TICAM1 MAPK8 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260410%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway TMPRSS2 ACE2 FURIN SLC6A19 SCARB1 ACAT1 NRP1 TLR7 CTSV;CTSL TMPRSS4 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260410%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders PECR ACADVL HADHB-1 ACSF2 CPT2 ACADS ACSL4 ACADM ACSL1 ACADL ECI1 EHHADH-1 ACSL3 HADH SCP2 HADHA SLC22A5 SLC25A20 CPT1A FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260410%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor TGFB1 TGFB3 SMAD2;SMAD3 MAPK10 COL1A1 FN1 MAPK9 RHO STAT3 ACTA2 CCN2 ENPP2 TGFB2 MAPK8 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260410%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway CASP8 CUL1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 UBE2J2 PSMD3 PSMD1 PSMC2-1 STUB1 CASP1 HSPA8 PSMD10 PSMD12 PSMD11 PSMD13 FBXW7 TUBA1C RNF19A HSPA14 TUBB4B TUBB1 HSPA1L HSPA4 TUBA4A HSPA6 UBE2G1 PSMD14 UBE2G2 SNCAIP PSMC5 TUBA3E;TUBA3C-1 PSMC6 PSMC3 TUBB4A;TUBB;TUBB8B;TUBB8 PSMC4 TUBA8 SNCA PSMC1 TUBB2B;TUBB2A UBA1 HSPA1A;HSPA1B TUBAL3 TUBA1A CCNE1 SIAH1 SIAH2 GPR37 CASK PRKN UBE2L6 TUBB3;TUBB6 UBE2J1 HSPA5 SEPTIN5 HSPA9 HSPA2 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260410%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation MYC LIN28B PRKAR1B PRKAR1A FGFR4 FGFR1 PRKAR2B PRKAR2A NRAS LATS1 LATS2 CDH10 HRAS CDH11 CDH12 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 IGF1R DCAF1 KRAS CUL4A FGFR3 TEK PRKACA-1 ITGAD ITGAM NGFR EGFR TEAD1 TEAD2 TEAD3 TEAD4 ITGB3 ITGA2B CDH9 CDH8 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 AJUBA CSF1R PAK1 SAV1 CXCL10 PAK2 NF2 ITGB1 FLT1 ITGB4 FLT3 FLT4 ITGB2 FOXM1 ITGAV ITGA4 ITGA3 ITGA2 ITGA1 DDB1 ITGA6 YAP1-1 INSR NTRK1 NTRK2 PRKACB-1 CDH1 KDR CCN2 EPHA2 WWTR1 PPP1CA PTK2 PPP1CC CCND1 CTNNB1 FGFR2 PDGFRB MST1 KIT ITGA10 VGLL4 CD44 ITGA11 CTNNA1 ITGB5 PAK3 PAK5 ITGB8 ITGB7 PAK4 ITGB6 PPP1R12A ITGA8 ITGA7 ITGA5 BUB1B-PAK6;PAK6 AMOT PDGFRA ITGA9 MET RBX1 PPP1R14A PPP1CB STK3 CDH20 CDH22 CDH24 ITGAE ITGAL PLCB4 ITGAX GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260410%WP4823%HOMO SAPIENS Genes controlling nephrogenesis PDGFB NPHS1 NPHS2 WNT4 EMX2 LHX1 LMX1B ROBO2 NCK2 NCK1 CXCL12 RET WT1 CTNNB1 ITGB1 FGFR2 PDGFRB GLI3 CD36 FOXC2 SHH SIX1 GDNF ILK FOXC1 FOXD1 ITGA3 MAGI2 SLIT2 ITGA8 CXCR4 TCF21 KIRREL1 LAMB2 HNF1B FGF8 MAFB NOTCH2 ETV4 HOXD11 KDR HOXA11 VEGFA PAX2 CD2AP EYA1 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260410%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways ERCC3 MSH6 MSH2 PMS2 PCNA RAD51 ERCC1 ERCC2 CUL4A FAAP100 REV1 CENPS-CORT;CORT;CENPS FANCM FANCL FANCE BRCA2 FANCF CETN2 REV3L POLI RAD23A RAD51C RAD23B FAN1 GTF2H2C;GTF2H2C_2;GTF2H2 FAAP24 RAD54B LOC105377022;FANCB CENPX APEX2 GTF2H1 APEX1 GTF2H3 GTF2H4 ERCC4 TERF2 MLH1 WRN XRCC6 DCLRE1C XRCC4 RAP1A POLM XRCC5 LIG4 POLL NHEJ1 POLK HMGB1-1 FANCG PRKDC WDR48 PARP2 FEN1 POLB EXO1 CDK7 FANCD2 MPG OGG1 PARP1 PNKP UNG XPA POLD3 POLD4 NTHL1 POLD1 BRIP1 TDG POLD2 POLE MUTYH RFC5 FANCI MBD4 RPA3 CHEK1 FANCA RFC3 RPA1 RFC4 PALB2 RPA2 LIG1 DDB1 RFC1 RFC2 RAD52 XRCC1 LIG3 ATR SMUG1 NEIL3 NEIL2 POLE2 POLE3 ERCC5;BIVM-ERCC5 USP1 ERCC8 ERCC6 DDB2 RAD50 MRE11 ATM NBN POLE4 MNAT1 BRCA1 POLH XPC RBX1 MSH3 MGMT FANCC CUL4B CCNH PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260410%WP5088%HOMO SAPIENS Prostaglandin signaling TGFB1 KLRD1 IL6 PYCARD CXCL10 AHR IL17F AREG IL17A CXCL9 CASP1 IL1A CSF1 CXCL2;CXCL3;CXCL1-1 CCR2 MMP9 IL12A PIK3CG IFNG IL1B CXCL8 PTGES NFKB1 IRF7 CCL3L1;CCL3L3;CCL3;CCL18 TNF NLRP3 VEGFA CD28 PTGER4 PTGER2 CCL13;CCL2 FOXA2 PATHWAY%WIKIPATHWAYS_20260410%WP5066%HOMO SAPIENS FOXA2 pathway FOXA1 SLC27A5 GSTM1;GSTM2-1 ACACA MTTP IRS1 GSTA3;GSTA5;GSTA1;GSTA2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SREBF1 IRS2 ABCC3 ABCC4 GSTA3;GSTA1 PPARGC1B FOXA2 FOXO1-1 ABCC2 INS;INS-IGF2 FASN APOB QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260410%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis ACOX2 MAFK MAFG MMP1 NFE2L2 NOS1 KEAP1 NFKBIA IKBKB NFKB1 FOS VEGFA PTGS2-2 CYP2A13;CYP2A6;CYP2A7-1 JUN WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260410%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD3 WNT3A NEUROG2 WNT5A NEUROD1 CCND1 WNT7A PROX1 WNT3 LRP6 FZD1 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260410%WP2249%HOMO SAPIENS Metastatic brain tumor MYC CDK6 CDC42 TP53 PIK3R1 E2F3 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260410%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis SPI1 TRAF6 RELA TLR2 TLR4 IRAK1 NFKB2 APOE INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260410%WP4558%HOMO SAPIENS Interferon mediated signaling IFNG JAK2 IL10RB IRF9 IFNAR1 IFNB1-4 PRKCA PIK3R1 IFNGR1 IFNLR1 IFNGR2 IFNE STAT1 STAT2 IFNK JAK1 IFNAR2 IFNL2;IFNL3;IFNL1 PIK3CA TYK2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260410%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 LDLR DGAT2 GCKR GCK CETP APOA4 MTTP LCAT LPL LIPC ACSS1 PLTP PDIA2 APOC2 APOA2 APOA1 APOA5 FAS LRP1 SEL1L LMF1 GPIHBP1 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260410%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN1 COL9A1 COL9A3 MATN3 COL9A2 COMP PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260410%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection CD14 HCLS1 ARPC1A NCK2 NCK1 ARPC4 ARPC5 KRT18 ARPC2 ARPC3 ARHGEF2 TLR5 CTNNB1 ITGB1 WASL FYN TUBB3;TUBB6 ACTB-1 TUBA1C RHOA OCLN-1 CLDN1 TUBB4B TUBB1 ROCK2 EZR ROCK1 TUBA4A WAS ARPC5L CDC42 PRKCA TUBA3E;TUBA3C-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 NCL-1 TUBB2B;TUBB2A CDH1 YWHAZ TUBAL3 TUBA1A CTTN YWHAQ ARPC1B TLR4 ABL1 ACTG1 LY96 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260410%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin PRKAR1A GUCY1B1 ANKRD1 TCAP FHL1 MYPN GUCD1 CSRP3 MAP2K2;MAP2K1 ANKRD2 NBR1 FHL2 CRYAB MAPK1 TRIM55 ANKRD23 CAMK2A RAF1 PLCZ1 PRKCA PRKACB-1 ADRB1 ADRB2 PRKACA-1 NUP62 NPR1 PRKG2 SRF TRIM63 MDM2-2 TTN-1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260410%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 ZEB1 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260410%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling IL27RA TRIM28 IL3RA IL20RA IL20RB IL21R IL22RA1 IL2RG MPL MAPK1 IL2RA IL2RB AKT1S1 MAPK4 MAPK3 MAPK14 MAPK12 MAPK10 MAPK13 MAPK7 RPTOR MLST8 JAK1 IFNAR2 CTF1 PIAS3 TYK2 AGTR2 AGTR1 IL10RB IL10RA F2RL3 IL6R IFNAR1 MAPKAP1 CREBBP CSF2RB CSF2RA EGFR SOCS3 MAPK11 GHR PDGFRB IFNGR1 IFNLR1 IFNGR2 CNTFR PTPRT SETD7 MAPK15 STAT3 PTPRD IL7R DUSP2 MTOR PTPRC IL12RB2 JAK2 JAK3 CSF3R PDGFRA PRKCB IL5RA F2R LIFR STMN1 OSMR IL9R IL6ST SRC DEPTOR MAPK9 IL11RA MAPK6 F2RL2 RICTOR MAPK8 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260410%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 CASP8 CASP3 FADD RIPK3 BIRC3 TRADD BAX TNFRSF1A TNF RIPK1 CASP9 CYCS-1 CASP7 PPP2CB;PPP2CA TRAF2 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260410%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 AEBP2 MTF2 EZH1 RBBP4 RBBP7 EED THRAP3 SETX EZH2 JARID2 MORC3 ELL BCLAF1 STK38 TRIM35 SUZ12 LUPUS THERAPIES%WIKIPATHWAYS_20260410%WP5560%HOMO SAPIENS Lupus therapies C2 IL6 MS4A1 C1QC IL6R CD19 IL17F IL17A CD22 C3-1 IL12B TNFSF13B IL12A IFNG IL23A IL25 CD40LG C1QB CD38 CD86 CD40 IL17D CD80 LOC110384692;C4A;C4B_2;C4B CD28 IL17C IL17B OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ALOX12 FPR2 PTGDS LTC4S GPR32 CYP2E1 FADS1 CYP2D6;LOC107987479;LOC107987478-1 LTA4H GSTM4 GGT1 GSTP1 PLA2G4A CYP1A2 DPEP1 PTGIS FADS2 ELOVL5 ELOVL2 EPHX2 PTGES PTGS1 ALOX5 TBXAS1 ALOX15B CYP2C9;CYP2C19 PTGS2-2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HPGD ALOX15 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260410%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy PLCB2 PPP3CA MAP2K5 CDK7 MAP2K2;MAP2K1 MAPK1 MAP2K7 MAPK4 DVL1 MAP2K6 PPP3CB MAPK3 MAP2K3 MAP2K4 RHOA FZD1 MAPK14 ROCK2 ROCK1 LIF IGF1R FZD2 MAPK7 IKBKE PDPK1 RAF1 CHUK EGF MYEF2 IKBKB PIK3CD AKT1 IKBKG NFKB1 EDN1 TAB1 RAC1 CTF1 HDAC9 GATA4 RCAN1 HDAC4 TGFB1 MAP3K14 PLA2G2A-1 IGF1 MYLK3 GSK3B PIK3R2 PRKG1 PIK3R1 LRP5 LRP6 CTNNB1 FGFR2 AKT2 STAT3 CISH MTOR EIF2B5 PIK3CB FGF2 PIK3CG NFATC4 CAMK2D WNT3A AGT WNT5A NRG1 PRKCB CDK9 IL6ST NPPB NPPA HDAC7 MYLK HDAC5 CALM1 TNF PIK3R3 PIK3CA MAPK8 PROLACTIN SIGNALING%WIKIPATHWAYS_20260410%WP2037%HOMO SAPIENS Prolactin signaling MYC CASP3 NFKBIB ELK1 PPIB ITGB1 MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 VAV2 JUN MAPK14 GRB2 SOS1 RAF1 PRL IRS1 NFKBIA AKT1 IRS2 CTSD YWHAZ NFKB1 FOS RAC1 JAK1 PIAS3 RPS6 GAB2 VAV1 FLNA ZAP70 PTK2 GSK3B PIK3R2 PIK3R1 CBL SOCS3 TEC SOCS1 SOCS2 EIF4EBP1 FYN STAT5A STAT1 PRLR STAT3 CISH PTPN11 MTOR RPS6KB1 SIRPA;SIRPB1;SIRPG PIK3CB NEK3 PTPN6 PPIA PIK3CG ERBB2 JAK2 YWHAG AGAP2 RPS6KA2 SRC PXN RELA MAPK9 STAT5B PTPN1 SHC1-1 PIK3CA PAK1 MAPK8 CAMKK2 PATHWAY%WIKIPATHWAYS_20260410%WP4874%HOMO SAPIENS CAMKK2 pathway VCAM1 CAMK1 SELL CDC25A SREBF1 MAPK1 MAPK3 FASN ACACA RAF1 PCK2 KEAP1 ICAM1 MAF TSC1 RPTOR IL15 CAMK4 PFKFB2 SIRT1 CCNE1 RAC1 RPS6 HMOX1 CREB1 HMBS CPOX AQP1 NFE2L2 NEDD4L MAP1LC3A RASGRP1 MAP1LC3B2;MAP1LC3B-1 GATM EP300 SQSTM1 SLC2A4 MTOR RPS6KB1 HFE MID1 IFI44L SPINT1 S100A8 CYB5R3 WFS1 TRPV4 MS4A3 OASL SLCO3A1 CTSE ERMAP GALNT9 GIT1 MAMDC2 ATP10D TSPAN33 EPOR SLC25A21 AHSP TMEM176B NFATC2 IRGC RHAG KLF1 TNF ATP1B2 PAK1 HK2 GCK HK1 WDR35 ARHGEF7 CXCL11 PLAC8 PARP1 CCR9 SLC38A5 SLC2A1 FIS1 CCL5 NLRP1 CHRM3 DNM1L CDH1 KDR CD28 CAMKK2 FAM20C ULK1 HDAC4 CRTC2 ABCA1 NOS1 CCND1 SPIRE1 ASNS STIM1 TBXT TSPAN8 SMC1A HIF1A RELA CALM1 PFKFB3 C1QTNF12 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260410%WP247%HOMO SAPIENS Small ligand GPCRs PTGDR TBXA2R S1PR3 LPAR1 MTNR1B PTGIR PTAFR S1PR1 CNR1 S1PR2 CNR2 GPR50 PTGFR MTNR1A S1PR4 PTGER4 PTGER1 PTGER2 PTGER3 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260410%WP5236%HOMO SAPIENS Markers of kidney cell lineage AXIN2 SFRP1 SMAD1 SIX1 AP2B1 BMP7 SMAD5 FOXD1 BMP4 TCF21 HNF1B KDR PAX2 RSPO1 NPHS1 NPHS2 WNT4 EMX2 LHX1 TNC REN JAG1 PBX1 WT1 PDGFRB KIT EPO ALDH1A2 GDNF PECAM1 EGLN1 DCN EGLN3 EGLN2 NTN1 WNT5A NOTCH1 HNF4A FGF7 FGF8 NOTCH2 HNF1A CITED1 RSPO3 NT5E TLX1 DACT1 ACTA2 SALL1 OSR1 KCTD1 DES SIX2 TSHZ3 TBX18 EYA1 FAT4 VSX2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260410%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 MYC ERBB2 PGR VIM FN1 EGF AREG CCND1 FOSL1 NRIP1 STAT5A ESR1 TIMP1 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260410%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds MBOAT1 SFRP4 CSNK1A1 AXIN1 LEF1 FZD7 TCF4 GSK3B APC FZD8 CTNNB1 DKK3 DVL2 LRP1 TNKS WNT1 FZD1 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP304%HOMO SAPIENS Kit receptor signaling MATK SOCS6 LYN GRB7 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 MAPK14 GRB2 RPS6KA1 SOS1 RAF1 AKT1 RPS6KA3 CRKL RPS6 GAB2 VAV1 BTK CRK PIK3R2 PIK3R1 CBL TEC SOCS1 EP300 FYN KIT STAT5A STAT1 STAT3 PTPN11 RPS6KB1 PTPN6 JAK2 INPP5D PRKCB MAPT PRKCA MITF GRB10 SRC PLCG1 SH2B2 STAT5B DOK1 KITLG FOXO3 SHC1-1 MAPK8 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260410%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TAF2 TAF13 MED27 H4C1 TAF8 MED23 TBP IL1 SIGNALING%WIKIPATHWAYS_20260410%WP195%HOMO SAPIENS IL1 signaling TAB3 PELI1 HSPB2 PELI2 MAP3K7 NFKBIB MAP2K2;MAP2K1 IL1A MAPK1 MAPKAPK2 MAP2K7 MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 MAP3K3 JUN MAP3K1 MAPK14 PRKCZ IRAK1 CHUK ATF2 IRAK3 IRAK4 IKBKB NFKBIA AKT1 IKBKG TRAF6 NFKB1 TAB2 TAB1 MYD88 IL1RAP ECSIT IRAK2 IL1R1 TOLLIP MAP3K14 UBE2N PIK3R2 PIK3R1 UBE2V1 SQSTM1 PTPN11 REL IL1B PLCG1 RELA MAPK9 MAPK8 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260410%WP528%HOMO SAPIENS Acetylcholine synthesis ACHE CHKA PDHA1 CHAT PEMT PCYT1A AMINO ACID METABOLISM%WIKIPATHWAYS_20260410%WP3925%HOMO SAPIENS Amino acid metabolism HIBADH PNMT AUH ARG2 GLUD1;GLUD2 PDK4 ALDH7A1 HIBCH CAD LARS2 TPH1 EHHADH-1 OAT PPM1L IARS1 PYCR1 HNMT VARS1 MPST AOC3 GOT1-1 MCCC1 TAT GLUL ODC1 CBS;CBSL MARS2 SMS LDHA PKM ADH4 PDHX ADH5 IDH1 RARS1 CPS1 SDS ARG1 ACLY PC ASS1 G6PC2 OTC HADH P4HA2 GOT2-1 TDO2 FARSB GSR GLS CTH BCAT1 FAH HAL GPT2 HMGCS2 HMGCL MMUT ASNS PDHA1 WARS1 DDC TH MAOA GSS FH DBH MDH2 ACADM DLST BHMT SDHA CS ADH1C;ADH1B;ADH1A FTCD ACAA1-1 EPRS1 OGDH ALDH18A1 SUCLG1 ACSS1 GCLM TPO ACO2 DLD HDC ALDH1A1 PCK1 MDH1 SRM TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260410%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IFNG KMO IL6 IL1B IFNB1-4 AHR HAAO AFMID GOT2-1 TDO2 AADAT KYAT3 KYAT1 KYNU IDO2 DDC TNF IDO1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260410%WP100%HOMO SAPIENS Glutathione metabolism OPLAH GSTT2B;GSTT2 IDH1 GSTM1;GSTM2-1 G6PD GGT5 GCLM GSTA3;GSTA5;GSTA1;GSTA2 GSTA3;GSTA1 GSR GGT1 GPX1 GCLC GPX4 GSS ANPEP GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260410%WP2363%HOMO SAPIENS Gastric cancer network 2 MYC SNURF MTDH COL9A1 COL9A3 PLAC8 EGFR CTNNB1 DSCC1 BRIX1 ATAD2 CACYBP FAM91A1 LBR UBE2C RNF144B UBE2T CD48 FANCI RFC3 RFC4 TOP2A CHTF18 RAD17 S100A6 AHCTF1 CEBPZ OTUD5 LMNB2 TP53 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260410%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners NF1 PRMT5 SKIL MECP2 MERTK HDAC1 SATB2 HDAC3 TEAD1 TEAD2 TEAD3 TEAD4 STK3 LATS1 LATS2 ING2 SIN3A SKI 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260410%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome TRAF1 CR2 LAT RAB5A CD19 ATP2A1 MPL IL4 C3-1 RABGEF1 NFATC2IP TUFM VAV2 ATXN2L SPNS1 RABEP2 TRAF2 JAK2 RAB4A GRB2 INSR SH2B1 NFATC2 CD82 KDR PRMT1 IFITM3;IFITM2;IFITM1 CD81 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B4GALT1 NAGA B4GALT3 FUCA1 B4GALT4 FUT2 FUT6;FUT5;FUT3 FUT1 NEU2 B3GNT5 ST3GAL4 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260410%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions SAV1 STK38L WWTR1 MOB1A;MOB1B CD19 LPL RAP1A TEAD1 TEAD2 MST1 TEAD3 TEAD4 LATS1 LATS2 CCR7 RHOA FOXO6 MAPK14 KNSTRN-1 FYB1 FOXO4 RAB13 FERMT3 YAP1-1 PRDM1 FOXP3 NDRG1 STK3 FOXO1-1 YWHAQ RASSF5 RAC1 FOXO3 ITGAL GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260410%WP2596%HOMO SAPIENS Gastric acid production GRP PGA4;PGA3;PGA5 SCT VIP PGC GAST MUC6 CBLIF CCK IL6 SIGNALING%WIKIPATHWAYS_20260410%WP364%HOMO SAPIENS IL6 signaling VAV1 IL6 IL6R BAD MAP3K7 GSK3B PIK3R2 GAB1 PIK3R1 CREBBP HDAC1 SOCS3 NLK MAP2K2;MAP2K1 MAPK1 STAT1 IRF1 STAT3 MAPK3 PTPN11 MAP2K4 RPS6KB1 HCK JAK2 AGT JUNB GRB2 SOS1 PRDM1 VIP PRKCD IL6ST CRP AKT1 BCL2L1 NCOA1 NR2F6 RAC1 JAK1 TIMP1 SHC1-1 TYK2 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260410%WP4504%HOMO SAPIENS Cysteine and methionine catabolism BHMT AHCY CDO1 MAT1A CSAD MPST SQOR GOT1-1 MTR-1 CBS;CBSL ETHE1 SUOX CTH GCLC GSS MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260410%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260410%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects TRH DUOX2 AGRP TG MC4R BAD FGFR1 PRDM16 MAP2K2;MAP2K1 PPARGC1A MAPKAPK3 RPS6KA6 SIRT6 MAPK1 KDM1A SHH HRAS AKT1S1 ITGAV NPY PPARG THRA DIO1 DIO3 MAPK14 GRB2 TSHB SOS1 RAF1 ADCY8 ATF2 TTF2 TTF1 ADCY3 NHSL1 IYD PRKACA-1 DUOXA2 ITPR2 SECISBP2L TSC1 SLC26A4 RPTOR FOXO1-1 PFKFB2 MLST8 TP53 ADRB3 TSHR RPS6 MDM2-2 RXRA WNT4 RHEB LOC100509620;LOC112267859;AQP7 GSK3B AKT3 CTNNB1 THRB FGF21 ITGB3 PAX8 FRS2 MTOR RPS6KB1 PLIN1 MGLL PNPLA2 ACTL6B NOTCH1 SLCO1C1 TSC2 SLC5A5 SLC16A10 SLC16A2 TBC1D4 NPPB SRC TPO KLB POMC MAP4K5 NPR1 MAFA PRKG2 ZNF516 CASP9 KDM3B CREB3 PIK3CA UCP1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260410%WP2806%HOMO SAPIENS Complement system SELL LAMC1 C5 GNA15 C6 C7 C9 C5AR1 FCN2;FCN1 F12 RPS19 C3AR1 F11 ADIPOQ MASP2 FPR1 C3-1 C8A FGB FGA KLKB1 ITGA2 SELPLG FGG LAMA5 ELANE WAS CSNK1A1 PLG TXN GNAI3 LAMB1 ICAM1 C5AR2 CRP PRKACA-1 TLR2 GNAI2 ICAM2 VSIG4 CD93 CFHR1;CFHR2 FCER2 APCS FKBP2 CPN1 CLEC4M;CD209-2 FCGR3A;FCGR3B ALB PTX3 CR2 LRP2 C2 CD55 C4BPA CD19 SERPING1 MASP1 CFB THBS1 CFI VTN CFP ARRB2 ITGB3 C1QBP ITGA2B SELP CFH-3 CFD ADM MBL2-1 PRNP C1S DCN PLAUR CD59 CR1L;CR1 F13A1 PRKCA F10 PROS1 APOA1 CALR-1 IBSP CD40 LOC110384692;C4A;C4B_2;C4B SELE SPP1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260410%WP241%HOMO SAPIENS One carbon metabolism MTHFD1L DNMT3A CHDH DNMT3B FOLH1B;FOLH1 MAT1A MTRR MAT2B MTHFD2 TCN2 TYMS AMT MTR-1 SHMT2 SHMT1 DHFR2;DHFR BHMT AHCY ST20-MTHFS;MTHFS ALDH1L1 FTCD ATIC MTHFD1 AHCYL2 GART MTHFR DNMT1 MTFMT GLRX PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260410%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins VPS11 VPS16 VPS18 OPTN-1 VPS33A VPS39 ATG3 VAMP8 RHEB VPS41 ATG9A TAX1BP1 ATG12-1 RB1CC1 ATG16L1 ATG4A MAP1LC3B2;MAP1LC3B-1 NBR1 LAMTOR1 EIF4B ATG7 TMEM59 SQSTM1 AKT1S1 MTOR ATG2B RPS6KB1 PPP1R9A PKM PRKAA2 ATG5 LAMP2 GABARAPL2 DEPTOR AKT1 RAB7A CALCOCO2 RPTOR MLST8 ATG13 LARP1-1 RPS6 APOB ULK1 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260410%WP5559%HOMO SAPIENS Lupus pathogenesis BCR IL6 PDCD1 TLR9 CD40LG TLR7 IL17A LOC102723996;ICOSLG TNFRSF13C ICOS TLR4 CD86 CD40 CD80 CD28 CD274 TNFSF13B EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260410%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance MYC EIF4E2 AXL BAD GAB1 ARAF NRAS MAP2K2;MAP2K1 RRAS MAPK1 HRAS BCL2 MAPK3 BRAF IGF1R GRB2 KRAS RRAS2 SOS1 PDPK1 MRAS RAF1 FGFR3 SOS2 EGF BAX RPS6KB2 PIK3CD AKT1 BCL2L1 KDR JAK1 RPS6 PDGFB NRG2 PDGFD PDGFC IL6 IGF1 IL6R GSK3B PIK3R2 PIK3R1 PDGFA CCND1 EGFR AKT3 FGFR2 PDGFRB EIF4EBP1 EIF4E AKT2 STAT3 PRKCG MTOR RPS6KB1 PTEN GAS6 TGFA PIK3CB NF1 FGF2 ERBB2 JAK2 HGF NRG1 PDGFRA PRKCB PLCG2 PRKCA MET SRC PLCG1 SHC4 SHC2 BCL2L11 SHC3 PIK3R3 FOXO3 ERBB3 VEGFA SHC1-1 PIK3CA VITAMIN D METABOLISM%WIKIPATHWAYS_20260410%WP1531%HOMO SAPIENS Vitamin D metabolism RXRB RXRA CYP2R1 DHCR7 PTH CYP27B1 VDR GC CYP24A1 CYP27A1 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260410%WP465%HOMO SAPIENS Tryptophan metabolism ASMT ECHS1 TPH2 TPH1 ACAT1 GCDH AOC1 ALDH8A1 AHR INMT HAAO AFMID AANAT KYNU STAT1 DDC IL4I1 MAOA CYP1A1 ALDH2 KMO HADH DLD GOT2-1 TDO2 AADAT KYAT3 KYAT1 IDO2 AOX1 CAT IDO1 ACMSD KALLMANN SYNDROME%WIKIPATHWAYS_20260410%WP5074%HOMO SAPIENS Kallmann syndrome ANOS1-1 GRB2 LHB FGFR1 OTX2 SEMA3E PROK2 FGF8 AKT1 MAP2K2;MAP2K1 MYRF CHD7 MAPK1 PROKR2 SOX10 PLXND1 GNRH1 PTPN11 ASCL1 FRS2 PIK3CA TMEM98 OLIG2 NEUROG1 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260410%WP3927%HOMO SAPIENS BMP signaling in eyelid development SMAD4 DKK2 BMP4 NOTCH1 SFRP1 FGF10 INHBB EGFR FGFR2 MAPK9 SMAD1 FOXC2 SHH MAPK3 SMAD5 PITX2 FOXC1 JUN TGFA MAP3K1 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260410%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism BCAT2 HIBADH ECHS1 AUH HIBCH ACAT1 ALDH6A1 HSD17B10 MCCC2 ACAD8 ACADSB ACSF3 PCCA DBT MLYCD MCCC1 MMUT DLD HMGCLL1 PCCB BCKDHA BCKDHB IVD BCAT1 IL19 SIGNALING%WIKIPATHWAYS_20260410%WP5422%HOMO SAPIENS IL19 signaling TGFB1 IL20RA IL20RB SOCS5 MMP1 IL4R SOCS1 MUC5AC MAPK1 STAT1 IL4 STAT3 MAPK3 STAT6 CCNB1 CCL11 MAPK14 COL1A1 CXCR4 AKT1 NFKB1 TNFRSF1A TNF IL19 RAC1 JAK1 ACTA2 MAPK8 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260410%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 F12 BDKRB2 KLKB1 CPN1 BDKRB1 SERPING1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260410%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV HOMER1 GRIN1 NLGN3 NLGN4X;NLGN4Y NLGN2 DLG2 MAPK1 ARC STX1A MAPK3 CYFIP1 FMR1 RYR2 CAMK2B CAMK2D RPH3A DLG1 GRIN2C CAMK2A GRIN2B GRIN2D NRXN3 NRXN2 YWHAG NRXN1;NRXN3;NRXN2 CAMK2G GRM1 TJP1 SHANK1 NLGN1 GRIN2A SYNGAP1 DLGAP1 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260410%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH2 ALKBH3 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260410%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ZMPSTE24 ICMT COCAINE METABOLISM%WIKIPATHWAYS_20260410%WP2826%HOMO SAPIENS Cocaine metabolism CES2 CES1 BCHE CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260410%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling CD3E CD4 CD247 IL17A CDK1 CD8A RRAS HSPA8 SAA2;SAA1 AKT1S1 C8A FGB FGA ITCH JUN FGG INTS4 TRPM2 HBD;HBB CTSV;CTSL CRP RPTOR MLST8 RAC1 JAK1 TLE3 ALB RPS6 TOMM70 APOL3;APOL4;APOL1;APOL2 PIAS1 IL18 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 LCK CTSB HLA-DRA IRF9 PRG3 CD2 IGLL5;IGLL1 MMP25 AHR NKRF EIF4A2 CD8B;CD8B2 MAP1LC3B2;MAP1LC3B-1 EIF4EBP1 FYN IL18RAP CCL1 EIF4E GP1BA STAT1 SELP MTOR PTPN6 IGFBP3 DDX58 IFI44L APOH IFIH1 MAVS CXCL13 IL9 PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 APOA2 APOA1 TNF ACTG1 CASP9 LBP MAPK8 CD14 CASP8 DDIT4 CASP3 UPF1 TNFSF10 NEK9 CXCL9 IL1A CCL23;CCL15 IL1R2 ACTB-1 CCR6 ATP6AP1 CCL11 MIB1 CXCR2 SRP54 BID CCL22 CCL21 CPN1 CCL20 CCL27 IL33 STEAP3 CCL26 C1QBP PRKCQ AGT TGFBR2 RRM2-1 CXCR1 TP53I3 NFKB2 LARP1-1 CCL8 IFITM3;IFITM2;IFITM1 MX1-1 BIRC5 MOV10 CASP5;CASP4 TF IL12A CXCL8 AKT1 IKBKG CTSD FOS CAMK4 SIGMAR1 IL13 ATG13 PTGS2-2 CCL13;CCL2 IL6 CARD11 RHEB FN1 NFATC3 CFB CFI CFP MARK2 CCR5 CXCL2;CXCL3;CXCL1-1 IL4 IL7 CFH-3 TLE1 CCL4L2;CCL4L1;CCL4 FGF2 IFNG C1S C1R IL1B G3BP1 CCNB2 GGH TPO DEPTOR ACE2 PARP2 IL5 CXCL10 CEBPB CXCL12 SMAD1 RTN4 SMAD5 ITGA3 TRAF2 TBK1 IRAK1 CCL5 NLRP1 IFNB1-4 CD163 NTRK1 IRF3 TRAF3 TRAF6 LGALS3BP APOD MYD88 SERPINE1 CXCL5;CXCL6 TBKBP1 ADAM9 ULK1 VPS11 VPS16 VPS18 VPS33A VPS41 DUSP1 IL10 APOC1 VPS36 GTSE1 WDR74 CD226 SKAP1 BTN3A1;BTN3A3 APOM HP;HPR BST2 HRG CTSZ SERPINA5 SDF2 CCNB1 ATP13A3-1 IL16 OS9 JAK2 SRP72 GSN JUNB LRG1 SRP19 IFIT1 PMPCB GABARAPL2 CLCC1 GTF2F2 PITRM1 G3BP2 NPTX1 MDN1 FAM83A TRO HIF1A TRIM59 ITIH4 ITIH3 RAP1GDS1 ERLEC1 EGR1 UGGT2 ATE1 COL7A1 NLRP3 FAM98A IL21 IL22 CD3G ROTENONE METABOLISM%WIKIPATHWAYS_20260410%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260410%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260410%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B HIRA H4-16 RBBP4 H4C1 SMIM40 H4C6 DAXX H2BC15;H2BC3;H2BC11;H2BC12 CHAF1A ATRX 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome MYC DYNC2H1 FNDC8 MYCBP2 FBXO45 BRINP1 TM4SF19 CEP350 WDR53 PAK2 ZNF76 NCBP2-1 MELTF NF2 RNF8 HAMP DYNLT1 TF DYNLT2B FBXW7 H2BC21 ADAM10 DYNC2LI1 JUN RABL2A;RABL2B CEP43 RNF168-1 TFRC SIRT1 PIGX-1 SLC40A1 TGFB1 PIGM UBE2N DYNLRB2 DYNLRB1 STAT5A SLC51A SLC51B HFE DLG1 NRROS DYNC2I2 DYNC2I1 PCYT1A PXN CEP19 HIF1A MCRS1 STAT5B PIK3R3 PIGZ SENP5 UBXN7 CASP7 MAD2L1BP-1 SMCO1 NCBP1 GRIA1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP558%HOMO SAPIENS Complement and coagulation cascades SERPINA1 CPB2 SERPINC1 TFPI C6 PLAT C7 C9 C5AR1 F12 C3AR1 SERPINF2 MASP2 F5 C3-1 FGB F8 KLKB1 F7 PLG C1QB F13B SERPINE1 LMAN1 CR2 C2 C1QC CD55 CLU SERPING1 MASP1 CFB CFI F2 CFH-3 C8G CFD BDKRB1 SERPINA5 VWF SERPIND1 C1S C1R PLAUR F3 CR1L;CR1 F2R PROC F9 F10 PROS1 KNG1 PLAU LOC110384692;C4A;C4B_2;C4B THBD CLTC SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260410%WP4814%HOMO SAPIENS Somatic sex determination RSPO1 PTGDS AMH WNT4 DMRT1 FOXL2 NR5A1 WT1 ZFPM2 CTNNB1 DHH GATA4 FGF9 SOX8 SOX9 SRY NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260410%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum CDK7 ERCC3 PARP1 GPS1 SLX4IP CHD1L XPA POLD3 POLD4 SLX4 PCNA POLD1 ERCC1 POLD2 ERCC2 POLE RFC5 RPA3 RFC3 RPA1 RFC4 RPA2 LIG1 DDB1 RFC1 RFC2 XRCC1 LIG3 H4-16 H4C1 CUL4A POLE2 H4C6 POLE3 CETN2 RAD23A RAD23B GTF2H2C;GTF2H2C_2;GTF2H2 GTF2H1 GTF2H3 GTF2H4 ERCC4 H3-3A UVSSA ERCC8 ERCC6 DDB2 XAB2 POLK POLE4 BRCA1 MNAT1 RAD18 POLH XPC RBX1 CUL4B HMGN1 CCNH USP7 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260410%WP4298%HOMO SAPIENS Acute viral myocarditis CASP8 CAV1 CASP6 CASP3 MYH6 DFFB DFFA CD4 PARP1 DAG1 CASP1 RASA1 EIF4G1 CAAP1 PTCRA CXADR MAPK1 ITGB2 CHRAC1 ACTB-1 BNIP2 BCL2 CCR3 MAPK3 IL12B MMP9 IL12A ENDOG LAMA2 SOS1 TICAM1 BAX NOD2 AKT1 HLA-DMA BCL2L1 RAC3 EDN1 CASP2 TLR4 BID JAK1 PABPC1;PABPC3 TGFB1 CREB1 IL6 PYCARD ABL2 CD55 GSK3B NOS1 PIK3R1 CCND1 IL10 TLR5 SOCS1 FYN SGCA EIF4G2 CCR5 IL2 STAT1 STAT3 ILK IFNG SGCD SGCB AIF1 KRT8 SGCG DMD CXCR4 CD40LG SRC TNF ABL1 CD80 ITGAL CASP9 NFKB2 CYCS-1 CASP7 TLR3 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases GALC NPC1-1 ARSA HEXB HEXA GBA GLB1 SCARB2 NPC2 GLA NEU3 GM2A NEU4 PSAP NEU1 LIPA NEU2 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260410%WP4236%HOMO SAPIENS Krebs cycle disorders FH PDHX DLST GPT SUCLA2 PCK2 SUCLG2 LDHA;LDHC SUCLG1 LDHB DHTKD1 MPC1 LDHA HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260410%WP186%HOMO SAPIENS Homologous recombination RAD52 BRCA2 POLD3 POLD4 POLD1 RAD51 POLD2 RAD50 RAD54B MRE11 RPA1 ATM NBN NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP268%HOMO SAPIENS Notch signaling KAT2B NUMB JAG2 JAG1 HDAC2 PSEN1 CREBBP NUMBL HDAC1 DTX1 CTBP2 APH1A LFNG CTBP1 NCSTN APH1B PTCRA KCNJ5 PSEN2 DVL1 DVL2 DVL3 NCOR2 RBPJ ADAM17 RBPJL DTX2 RFNG DTX3 DTX3L KAT2A MFNG NOTCH1 DLL1 MAML3 DLL3 DLL4 DTX4 HES1 INPP5K HES5 NOTCH2 NOTCH3 NOTCH4 MAML1 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260410%WP619%HOMO SAPIENS Type II interferon signaling HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IRF4 NOS2 IRF2 CXCL10 IRF9 SOCS3 CXCL9 CIITA SOCS1 SPI1 IFNGR1 EIF2AK2 IFNGR2 STAT1 IRF1 STAT2 ISG15 PTPN11 TAP1 IFNG GBP2;GBP3;GBP1 JAK2 IL1B IFNB1-4 PSMB9 PRKCD OAS1 ICAM1 IRF8 IFIT2 REG1B;REG1A JAK1 CYBB OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases WNT16 FGFR4 FGFR1 FGF10 BMPR2 PTCH1 IHH GLI3 MYOD1 MAPK1 WNT6 GLI2 WNT11 MAPK4 SMO MAPK3 RBPJ WNT1 WNT2 WNT3 FZD1 WNT10B MAPK14 WNT10A MAPK12 FZD3 MAPK10 HES3 MAPK13 FZD2 BMP4 HES2 FZD5 BMP2 MAPK7 FGF18 WNT7B FZD7 FZD6 FGFR3 FZD9 BMPR1B FZD8 WNT7A PIK3CD PIK3R6 PIK3C3 PIK3R4 PIK3R2 PIK3R1 LRP5 LRP6 STAT1 RUNX2 FGF1 HES6 FGF2 FGF3 FGF4 NOTCH1 DLL1 FGF5 DLL3 DLL4 FGF6 FGF7 FGF8 PRKDC PIK3R3 PIK3R5 MAPK8 SMAD1 SMAD9 SMAD5 PPARG PRKCZ FGF9 SOX9 WNT4 JAG2 JAG1 FZD4 HEY1 HEY2 MAPK11 CTNNB1 FGFR2 WNT9B WNT9A BMPR1A PRKCG WNT8A PRKCQ WNT8B PIK3C2G PIK3CB PIK3C2A PIK3CG SMAD4 PIK3C2B WNT3A PRKD1 WNT5A PRKCH PRKCB PRKCE PRKCD PRKCA WNT2B NOTCH2 FZD10 NOTCH3 NOTCH4 MAPK9 PRKCI MAPK6 WNT5B PIK3CA MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PAK2 BAD GAB1 STRN ARAF NRAS MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 CDKN1A JUN BRAF C8orf34 GRB2 CDC42 KRAS SOS1 RAF1 SOS2 PIK3CD AKT1 CRKL ELOA RAP1B KDR RAC1 INSL3 RAPGEF1 CRK ETS1 PTK2 PIK3R2 PIK3R1 CBL PRCC RAP1A AKT3 TFE3 AKT2 STAT3 PTPN11 PAK3 PAK5 PAK4 PIK3CB JAK3 HGF BUB1B-PAK6;PAK6 MET SRC PLCG1 RPL11 PIK3R3 VEGFA ALK PIK3CA PAK1 MAPK8 IL17 SIGNALING%WIKIPATHWAYS_20260410%WP2112%HOMO SAPIENS IL17 signaling MAP3K14 CEBPB MAP3K7 GSK3B IL17F NFKBIB IL17A IL17RB MAPK1 STAT3 IL17RC MAPK3 IL17RA IL17RD TRAF3IP2 JAK2 IL25 IL17RE IKBKB SP1 AKT1 IKBKG TRAF3 RELA TRAF6 NFKB1 CEBPD JAK1 IL17D IL17C PIK3CA IL17B MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260410%WP2005%HOMO SAPIENS miR targeted genes in muscle cell PPP3CA E2F1 CLOCK ACAA2 PLK1 ATAD3A;ATAD3B LAMC2 LAMC1 PXDN NEDD4 MAPK14 MAPK12 FADS2 MAPK7 KRAS TMEM87A HYAL3 VSNL1 LAMTOR3 FSTL1 CAMTA1 DSG2 IRS1 GNA13 MYO1E CPOX LPL EGFR CYP1B1 EIF4E FAR1 BACE1 ESR1 PDCD4 COL1A1 COL3A1 ADAR CCNG1 TPM4 TPM3 RB1 TPM2 TPM1 LMNB2 EHMT2 DNMT3A EHMT1 CYP51A1 SLC38A1 TDG POLD2 GRIA2 BCL2 SLC38A2 SLC38A5 SLC25A13 COL1A2 HDAC4 GSTM4 PSAT1 MTRR CCND1 CTNNB1 CBFB C1QBP GALNT1 ERBB2 CAND1 WNT5A TGFBR2 MET NOTCH2 NAA15 CUL4B RAVER2 ANKFY1 TMEM41B-1 MBNL1 CACNA2D1 FNDC3B FNDC3A SCAMP1 WDR82 HACD3 KCNQ1 GRPEL2 MOV10 NRP1 STRN PANX1 ELMOD2 PAFAH1B2 E2F3 PPP1R7 TXNRD1 TTC9C HIPK3 NFIA SNX15 NUCB1 PKN2 LAMTOR5 CDKN1A LTN1 PHLDB2 ATRX LCLAT1 IPO4 ABHD10 ARID1A POGLUT3 KPNA3 RARS1 STX7 RAB30 DMTF1 SYPL1 SRSF9 UAP1 SLC9A3R2 SLC4A10 NCL-1 P4HA2 CDK6 CNOT9 CALCOCO2 SYNE2 EZH2 SYNE1 SNAP29 NCOA3 RAD23B IGF2BP1 MTPN SEC23A LUZP1 NUFIP2 HSD17B12 TP53INP1 SH3BP4 HMOX1 ZNF622 SLC25A24 SLC12A2 SLC12A4 RHEB MYO10 TM6SF1 SLC25A32 BET1 CPNE8 VEZT SRPRB-1 PWP1 CIAO2A SEC62 CCN1 CSF1 CSNK1D DHX40 CARHSP1 METTL7A-1 UBE2J1 COMMD9 ATP6V1C1 ASH2L RAB27B POLA2 FGF2 NCEH1 ANP32B GFM1 PTPRJ NOTCH1 MAGT1 COIL DHX15 GNL3L-1 ACVR1B HES1 GNPNAT1 TMED7 MRPS24 AP3B1 CSDE1 AGO3;AGO1 PTMA SSNA1 NAPG NT5E PGRMC1 TUSC2 MPZL1 ARID4B ERBB3 ARF4-1 SPRYD4 TXN2 ARHGDIA ANPEP SPCS3 CHORDC1 TPPP3 CDK5RAP1 GPAM GFPT1 AXL CDK5RAP3 PGM1 VPS39 MCL1 G6PD IFRD1 ATG9A UBE4A CEBPB PISD CDKAL1 CXCL12 MTHFD2 GPD2 RAB34 GEMIN7 PPIF RAI14 NF2 WDFY1 SDCBP MATR3 PPIB ANAPC1 CHMP2A PICALM ITGB4 TMED10 DOCK5 SLC1A4 DOCK7 ADIPOR2 CHD1 AMIGO2 RTN4 CORO1C TMED2-1 MRPL20 HSDL1 RDH10 RAB6A SNX6 ITGA2 RCN2 RBMS1 NXN LRRC8A ATP6V0A1 PKM CD164 PDLIM7 GALNT7 SLC4A7 TBCA UHRF1 TRAM1 IGF2R SFXN1 SLC25A1 SNAP23 TNFAIP2 ATP2A2 SLC7A11 SPARC MRC2 SPTLC1 YWHAQ TMEM43 CSRP1 TMED3 TMEM109 ACP2 LRP1 SH3BGRL3 NELFCD CTSC SCYL1 ERG TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A RHOG MYLIP PTBP2 GAK SLC7A6 ZEB1 PDE3A CDCP1 RFT1 FRG1 BRPF3-1 CAPG TYMS THBS1 PTPA DNAJB1 KIT POLR2C USP1 SHOC2 PDLIM5 CDIPT SRSF10 CA12 SEC24A AP3D1 ARCN1 WDR11 ABCG2 POLE4 ATP6V0E2;ATP6V0E1 CLDN1 FMNL2 CDKN1B GJA1 PTPRF PRKCI PODXL SRF BACH1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260410%WP4147%HOMO SAPIENS PTF1A related regulatory pathway KAT2B NOTCH1 PDX1 NKX6-1 FGF10 HES1 RBPJ RBPJL PROX1 PTF1A CTNNB1 CHOLESTASIS%WIKIPATHWAYS_20260410%WP5238%HOMO SAPIENS Cholestasis EPHX1 LDLR RXRA NR1H4 SLCO1A2 ABCB4 SLC22A1 ABCB11 TJP2 ABCG8 ABCC3 ABCG5 ABCC4 ABCC2 NR1I3 HMGCR SLC10A1 ATP8B1 SCARB1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260410%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex MBD3 KAT2B HAT1 TAF12 MTA1 HDAC2 HDAC1 H2BC5 MAPK3 H2BC1 H2AC14 H2BC21 H2AC20 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KAT2A H4-16 POLR1A RBBP4 POLR1B POLR1C H4C1 POLR1D H4C6 SRCAP PWWP2B ASF1B CHD3 PWWP2A RRN3 TAF1D TAF1C UBTF TAF1A EP400 MTA2 MBD2 GATAD2B GATAD2A CDK2AP1 H2AZ2;H2AZ1 ASF1A TLK2 H2AJ H2AB2;H2AB3;H2AB1 CREBBP H2BC15;H2BC3;H2BC11;H2BC12 CHD4 EP300 TAF1B TBP CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260410%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells CARNS1 SLC15A4 SLC6A6 SLC15A2 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260410%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control PYCR2 MCL1 AFG3L2 ATAD3A;ATAD3B PYCR1 TXNRD2 TIMMDC1 CLPP LONP1 HTRA2 USP9X PLEK OPA1 TRAK1 MFN1 VCP-1 MFN2 DNM1L AIFM1 HSPD1 PYCR3 UBXN1 CLPB MICOS13 OPA3 PINK1 GDAP1L1 PMPCA UBXN6 SLC25A46 OXA1L PPA2 YME1L1 MICU1 SPG7 UFD1 PRKN MFF TIMM50 MSTO1 MARCHF5-1 DNAJC19 TIMM8A AGK C1QBP TMEM126A-1 STAT2 GFER COQ5 COQ3 NPLOC4 SFXN4 RTN4IP1 MIPEP SACS PMPCB PITRM1 XPNPEP3 HSPA9 TXN2 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260410%WP134%HOMO SAPIENS Pentose phosphate metabolism PGD RPIA G6PD RPE;RPEL1 TALDO1 TKT PGLS CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies GZMH;GZMB-1 IFNG CD4 EGFR F2RL1 DHODH IL15 IL2 TGM2 TNF IL21 ITGA4 ITGB7 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260410%WP4155%HOMO SAPIENS Endometrial cancer MYC AXIN2 BAD FGFR1 ARAF ELK1 NRAS MAP2K2;MAP2K1 MAPK1 HRAS MAPK3 CDKN1A BRAF TCF7L2 TCF7L1 GRB2 KRAS SOS1 BAK1 PDPK1 RAF1 GADD45B FGFR3 SOS2 EGF GADD45A GADD45G BAX PIK3CD AKT1 CDH1 FOS TP53 GSK3B PIK3R2 TCF7 PIK3R1 CCND1 EGFR AKT3 CTNNB1 FGFR2 AKT2 DDB2 CTNNA1 CTNNA3 CTNNA2 ILK POLK PTEN PIK3CB FGF1 FGF2 ERBB2 AXIN1 LEF1 APC PIK3R3 APC2 FOXO3 CASP9 PIK3CA EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260410%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TRAF1 PDLIM7 MAP3K14 IRAK1 CCL5 IFNB1-4 MAP3K7 CHUK CXCL8 TRADD NFKBIA IKBKB IKBKG RELA TRAF6 NFKB1 MAPK1 HSP90AA1 TNF CCL20 NFKB2 MAP3K3 MAPK8 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260410%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC3 SMC1A MAD2L1 BUB1B BUB3 APC PTTG1;PTTG2 BUB1 ESPL1 MAD1L1 RAD21 CDC20 CENPE STAG1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2877%HOMO SAPIENS Vitamin D receptor pathway MYC STAM CDKN2B SFRP1 BTLA CASP14 SOSTDC1 CASP5;CASP4 IGFBP5 COLEC11 SALL4 CDKN2D CBS;CBSL ALPG;ALPP;ALPI-1 S100A4 CDKN1A IL12A TNFSF4 KLK6 PTHLH KRTAP8-1 IL25 CDX2 GADD45A MXD1 CD200 CTLA4 ALOX5 ITGAM FOXO1-1 IRF8 CCNE1 SULT2A1-4 ID1 TREM1 PTGER4 KLF4 IRF4 RXRA ATP2B1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 G0S2 CYP2S1 CDK2 NOX1 ABCB1 LRP5 RASGRP1 NRIP1 SLC2A4 BDKRB1 LPGAT1 GXYLT2 CDKN2A KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 SPRR1A;SPRR1B IGFBP3 CYP1A1 KRT16;KRT14 KRT71 IGFBP1 S100A8 CAMP SLC34A2 IRF5 STS S100A2 TRPV5 CDC34 CYP27B1 NINJ1 VDR PRDM1 COL13A1 CRACR2A CYP24A1 CRACR2B DEFB4A;DEFB4B SLC37A2 CYP7A1 PNOC SLC8A1 CLPTM1L IGSF9B EPHB4 ORM2;ORM1 DUSP10 DACT2 CA9 NFATC2 ABCD1 TPM1 SERPINB1 LGALS9C;LGALS9;LGALS9B ID4 SATB1 SEMA3B CLEC16A ASAP2 CYP2B6 CD40 CST6 CYP2C9;CYP2C19 CLMN CREG2 TNFAIP3 LRRC25 S100G THBD KRT13 SPP1 MYO9B CD14 DEFB132 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 DNER CD9 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 G6PD CEBPA CLDN2 CDKAL1 TRPV6 SULT1C2 LRRC8A ATP2C2 BCL6 TRAK1 HSD17B2 IL1RL1 STEAP4 ADGRE5 TGFB2 TGFB1 CYP2D6;LOC107987479;LOC107987478-1 KL ADRA1B CCND1 ADAMTS5 CDKN2C TIMP3 BMP6 PPARD PRKCQ TIMP2 CDKN1B MED9 JUNB S100A6 EFNA5 ADRB2 HIF1A HNF1A S100A9 DND1 KNG1 PTH TNFRSF11B CCNC-1 TNFSF11 FGF23 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260410%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC2A1 PSPH SLC1A5 PSAT1 PHGDH GLS SLC7A11 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260410%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence ALOX12 PTGDS LTC4S CYSLTR1 LTA4H MAPK11 IGFBP5 NRAS HRAS CDKN1A PLA2G4A PTGIS KRAS GNAS-1 PTGES ADCY3 GNAI1 PTGS1 RB1 ALOX5 PRXL2B TBXAS1 SIRT1 ALOX15B TP53 PTGER4 PTGS2-2 PTGER1 PTGER2 ALOX5AP PTGER3 ALOX15 GNAQ PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260410%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart MAPK14 NFATC4 PPP3CA CAMK2D AGT PRKCB PRKCE LIFR MYEF2 MAPK11 IL6ST EDN1 MAPK1 FOS CALM1 STAT3 RAC1 PPP3CB CTF1 MAP2K3 GATA4 JUN RHOA MAPK8 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260410%WP2795%HOMO SAPIENS Cardiac hypertrophic response PPP3CA MAP2K5 LOC118142757;GUCA1A CDK7 MAP3K7 MAP2K2;MAP2K1 MAPK1 MAP2K7 MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP3K1 MAPK14 MAPK7 IKBKE PDPK1 RAF1 CHUK EGF IKBKB AKT1 IKBKG NFKB1 TNFRSF1A RAC1 HDAC9 HDAC4 TGFB1 MAP3K14 PLA2G2A-1 IGF1 GSK3B PRKG1 MAP4K1 FGFR2 AKT2 MTOR TGFBR1-1 FGF2 CAMK2D PRKD1 NRG1 PRKCA CDK9 NPPA MEF2A HDAC7 HDAC5 NFATC2 CALM1 TNF MAPK8 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260410%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TP63 TGFB3 IRF6 ARHGAP29 ARHGEF2 RHOA TFAP2A GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260410%WP4157%HOMO SAPIENS GABA metabolism aka GHB DPEP1 GAD2 ALDH5A1 GLS2 MAOB GLS ADHFE1 PON3 AKR7A2 ABAT GAD1 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260410%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway TGFB1 IGFBP7 DDR1 BMP2 EXOC6 FN1 LOXL4 NFE2L2 ANXA5 FGF7 PKD1 COL2A1 SUV39H1 SIRT1 ECSIT NRF1 CDC37 NQO1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260410%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAP3K10 MAPK11 MAP3K11 MAP2K2;MAP2K1 EIF4E MAPK1 MAP2K7 BCL2 MAP2K6 MAPK3 MAP2K3 MAP2K4 BST2 JUN MAP3K1 MAPK14 MAPK12 MAPK10 MAPK13 JUNB RPS6KA1 RAF1 ATF2 RPS6KA2 RPS6KA3 MAP3K9 MAPK9 MAP3K4 FOS DDIT3 IFITM3;IFITM2;IFITM1 MAPK8 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome F11R AMELY;AMELX ACP6 PRKAG1 PYGO2 PRKAG2 TJP3 PRKAG3 CTNNB1 CHD1L PRKAA1 PYGO1 BCL9 OCLN-1 PRKAA2 FMO5 KIRREL1 GJA1 TJP2 GJA3 TJP1 GJA5 GJA8 PRKAB2 PRKAB1 AFDN PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260410%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE8B PDE8A PDE1C PDE1B PDE1A PDE12 PDE9A PDE11A PDE6C PDE6B PDE6A PDE6H PDE10A PDE7B PDE7A ADCY4 PDE6D GRIN2C GRIN2B ADCY1 GRIN2D ADCY8 ADCY7 ADCY6 ADCY5 ADCY3 ADCY2 PRKACA-1 PDE2A CHRNA7;CHRFAM7A PDE4D-1 DRD1 GUCY1A2 PDE3B GUCY1A1 CREB1 GUCY1B1 PDE4C PDE3A PDE4B GRIN1 PDE4A ADORA2A PDE5A NOS1 PRKG1 PPP1R1B DRD2 CAMK2A ADCY9 ADCY10 GRIN2A GRIA1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway GPR37 CASP6 CASP3 PINK1 UBE2J2 CCNE2 MAPK11 APAF1 PRKN UBE2L6 SYT11 DDC UBA7 TH UBE2J1 MAPK14 HTRA2 SEPTIN5 MAPK12 UBE2G1 MAPK13 UBB;UBC UBE2G2 SNCAIP EPRS1 SLC6A3 SNCA UCHL1 UBA1 CASP2 CCNE1 PARK7 LRRK2 CASP9 CYCS-1 ATXN2 CASP7 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260410%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy BECN1 PIK3C3 ATG5 ATG3 ATG10 PIK3R4 ATG12-1 MAP1LC3A ATG16L1 RB1CC1 ATG4A ATG7 WIPI1 ZFYVE1 ATG16L2 ATG13 MTOR ULK2 ULK1 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260410%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging AKT1 FOXO1-1 IGF1R SIRT1 MTOR PTEN GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260410%WP2261%HOMO SAPIENS Glioblastoma signaling E2F1 MAP2K5 CDKN2B FGFR1 GAB1 MDM4 MSH6 ARAF CDK4 NRAS MAP2K2;MAP2K1 MAPK1 MAP2K7 HRAS MAP2K6 MAPK3 MAP2K3 CDKN1A MAP2K4 SPRY2 BRAF FOXO4 IGF1R PRKCZ GRB2 KRAS PDPK1 RAF1 IRS1 PIK3CD BRCA2 AKT1 CDK6 TSC1 FOXO1-1 CCNE1 TP53 MDM2-2 CDK2 PIK3R2 PIK3R1 CBL CCND1 EGFR AKT3 FGFR2 PDGFRB CDKN2C EP300 AKT2 PRKCG PTEN PRKCQ ATM PIK3C2G PIK3CB BRCA1 CDKN2A PIK3C2A NF1 PIK3CG ERBB2 ERRFI1 CDKN1B PIK3C2B PRKCH PDGFRA PRKCB TSC2 PLCG2 PRKCD PRKCA MET SRC PLCG1 RB1 CCND2 PRKCI FOXO3 ERBB3 PIK3CA NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260410%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification SAT1 LPAR1 JAG2 NOTCH1 DLL1 JAG1 DLL3 DLL4 FGFR3 CALU ALPL PLAT SOX6 GJA5 VEGFA MGP ITGA1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260410%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms SAV1 WWTR1 PAK2 LIMD1 NF2 MAP4K1 MAP4K2 CTNNB1 ITGB1 TEAD1 TEAD2 MST1 ACTA1 SGMS1 ITGB4 TEAD3 TEAD4 LATS1 ITGB2 ACTB-1 ITGB3 CTNNA1 ITGB5 PAK3 PAK5 ITGB8 MAP4K3 ITGB7 PAK4 ITGB6 MAP4K4 MAPK10 ACTC1;ACTG2 BUB1B-PAK6;PAK6 YAP1-1 SRC CDH1 STK3 MAPK9 YWHAQ MAP4K5 ACTG1 ACTA2 PAK1 MAPK8 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260410%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy TGFB1 AKT1 NFKB1 AKT2 PPP3R1 STAT3 RASGRF1 MYEF2 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260410%WP4217%HOMO SAPIENS Ebola virus infection in host HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CAV1 RAB5A MAPK1 EPS15 MAPK3 NEDD4 TFAP2A IGF1R CTSV;CTSL AKT1 PIK3CD HLA-DMA RAC1 CLTCL1 HLA-DPB1-1 HLA-DOA HLA-DOB HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 NPC1-1 HLA-DQB2;HLA-DQB1 HLA-DMB HLA-DRA CTSB PIK3R2 PIK3R1 CREBBP TYRO3 SOCS3 EGFR EP300 EIF2AK2 IL4 ITGB3 RASA2 RELB STAT1 MBL2-1 GAS6 REL DDX58 MERTK TIAM1 FOLR1 ACTN4 PIK3R3 RHOC ACTG1 PAK1 CLTC CLTB AXL CLTA VPS39 ITGB1 TOP1 ACTB-1 ICAM3 KPNA1 TIMD4 ITGAV CLEC4G ITGA4 CLEC6A ITGA3 VAV2 ASGR1 ITGA2 ITGA1 RHOA DAB2IP RAB9A RFC1 ITGA6 TBK1 CDC42 IKBKE ACTN1 IRF3 RAB7A NFKB1 IRF7 ICAM2 TLR4 CLEC4M;CD209-2 VPS11 FLNA VPS16 FLNB VPS18 FLNC VPS33A VPS41 NPC2 CAV3 C1QBP TSG101 SCIN ADAM17 BST2 TPCN2 PIK3CB EIF2S1 ITGA5 VPS4A GSN MFGE8 RHOB RELA PRKRA HAVCR2 IQGAP1 NFKB2 PIK3CA CAV2 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders GALNT3 PHEX CYP27B1 CYP24A1 ROS1 FGFR3 KL DMP1 CCND1 ALPL FGFR2 NFKB1 PTH CYP11B1;CYP11B2 ORAI1 FGF23 SLC34A1 NFKB2 CDKN1A ENPP1 FAM20C SPP1 FOXP3 IN COVID 19%WIKIPATHWAYS_20260410%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL6 IL6R IL2RG IL6ST FOXP3 STAT5A IL2 IL2RA IL2RB STAT5B CD86 STAT3 IL7R CD80 CD28 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260410%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling CASP8 TRAF1 CASP3 TRAF5 MAP3K14 FADD MAP3K7 BIRC2 GSK3B BIRC3 HDAC1 NFKBIB TNFRSF12A CTNNB1 MAPK1 RELB AKT2 MAPK3 JUN TRAF2 MAPK14 RAF1 CHUK IKBKB NFKBIA AKT1 TRAF3 RELA MAPK9 NFKB1 TNF RIPK1 RAC1 TRIM63 NFKB2 CASP7 MAPK8 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260410%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GIP GCG TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260410%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NADSYN1 NMNAT1 KMO NAPRT NMRK1 NMNAT3 NMNAT2 HAAO AFMID NMRK2 TDO2 AADAT KYNU NAMPT QPRT IDO1 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260410%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RXRB RXRA ALDH1A3 RXRG RARA CYP2E1 LPL RDH8 RARG RLBP1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 RPE65 RDH12 RBP4 MAPK1 CD36 RBP1 RDH5 LRAT ALDH1A2 RDH10 RARB CRABP2 CRABP1 CYP26A1 CYP26B1 ADH4 NPC1L1 RETSAT BCO2 DHRS3 RBP7 RBP2 ADH1C;ADH1B;ADH1A SDR16C5 AWAT2 ABCG8 ABCG5 ALDH1A1 DGAT1 BCO1 SULT2B1 SCARB1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260410%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HFE HAMP TMPRSS6 ID1 SMAD7 HJV BMP6 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260410%WP5293%HOMO SAPIENS Acute myeloid leukemia MYC CD14 MPO CEBPA BAD ARAF NRAS MAP2K2;MAP2K1 GLI1 FLT3 PML MAPK1 HRAS MAPK3 BRAF TCF7L2 TCF7L1 GRB2 KRAS SOS1 RAF1 CHUK CEBPE SOS2 RPS6KB2 IKBKB PIK3CD AKT1 IKBKG NFKB1 ITGAM FCGR1A RARA DUSP6 JUP PIK3R2 TCF7 PIK3R1 PER2 CCND1 CCNA2-1 AKT3 CSF2 BCL2A1 SPI1 EIF4EBP1 KIT STAT5A AKT2 STAT3 PPARD MTOR RPS6KB1 PIM1 PIK3CB CCNA1 RUNX1T1 RUNX1 LEF1 PIM2 RELA STAT5B PIK3R3 IL3 ZBTB16 PIK3CA CSF1R PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4224%HOMO SAPIENS Purine metabolism and related disorders AMPD1 APRT DGUOK PAICS ITPA TPMT PRPS1 MAT2A PPAT ADA MOCOS PNP-1 PFAS ATIC GART HPRT1 GRM5 RRM2B XDH ADSL AOX1 IMPDH1 ADSS2 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260410%WP5546%HOMO SAPIENS 22q11 2 distal CNV CAMK1 LRP4 CDC16 MAPK1 NEDD4 CD79A CD79B CAMK4 RACK1 AQR TP53 RPS6 MDM2-2 SNW1 SF3A3 IGLL5;IGLL1 IQUB ROPN1L CBL RSPH6A NME5 PRKN DYDC1 SF3B4 HSPA5 CAMK2A PDIA2 CALR-1 UBE3A PAK1 DNAJB13 GNAZ PAK2 RPS15 PPIB RPS14 RPS17 RPS16 RPS19 RPS18 CHEK1 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RSPH9 RPS8 RPS5 RPSA ATF6 RNF19B RSPH3 PPIL1-1 VPREB1 SNRPD2 UBA1 SNRPD1 CWC22 SNRPD3 SRRM2 HYOU1 ZNF280D;ZNF280A CRNKL1 RPS15A PDIA4 RAB36 RPS3 EFTUD2 ERP29 PPIE RPS2 SNRPF SNRPB UBA6 RPS27A SOX9 CABP1 PRPF8 AK8 SNRPE-2 BCR CWC15 TDRD3 DHX16 ARIH1 RPS29 TOP3B CCDC116 RPS20 BUD31 PLRG1 SF3B1 FAU RPS21 YDJC RPS24 CANX SDF2L1 RPS23 SNRPA1 ELOB RBM22 SF3B5 SF3B2 SF3B3 PPM1F PTPA RNF113A PRAME SNRPG-2 DNAJB11 RILP UGGT1 SF3A1 SF3A2 XAB2 PPIL2 CDC5L SNRNP40 PHF5A SNRNP200 YPEL1 PPIL4 PPIL6 XBP1 SNRPB2 RBX1 CUL2 HSP90B1 ELOC-1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260410%WP1584%HOMO SAPIENS Type II diabetes mellitus SURF1 SLC2A2 KCNJ11 SOCS4 PHKA2 PRKCZ GK INSR IRS1 IKBKB MAPK1 PDX1 SLC2A4 ADIPOQ MAFA TNF INS;INS-IGF2 MTOR PIK3R5 CACNA1A MAPK8 IL3 SIGNALING%WIKIPATHWAYS_20260410%WP286%HOMO SAPIENS IL3 signaling LYN IL3RA CD69 BAD YWHAB MAP2K2;MAP2K1 MAPK1 HRAS BCL2 CCR3 MAPK3 HCK JUN ENPP3 GRB2 SOS1 RAF1 CXCL8 PIK3CD AKT1 PRKACA-1 BCL2L1 CRKL YWHAQ FOS JAK1 SYK GAB2 VAV1 TGFB1 RAPGEF1 PIK3R2 PIK3R1 CSF2RB CBL FYN STAT5A STAT3 PTPN11 PTPN6 JAK2 INPP5D IL5RA SRC STAT5B CD86 IL3 SHC1-1 MAPK8 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260410%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria NDUFB6 NDUFA12 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFV1 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFC1 NDUFS6 NDUFAB1 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFS5-1 NDUFB9 SLC25A6 COX6C SLC25A4 UCP2 COX17 SCO1 UCP3 UQCRFS1 COX11 NDUFA11 COX6A1 COX6A2 COX6B1 UQCRC1 UQCRC2 UQCRB ATP5MC2 ATP5MC3 COX7A2 SLC25A5 ATP5MC1 UQCRQ COX7B COX4I1 COX7C SURF1 COX8A ATP5IF1 NDUFA13 NDUFA10 NDUFS8 SLC25A14 SDHC NDUFS7 COX15 SDHD COX7A2L-1 SLC25A27 SDHA ATP5MG SDHB UQCR11 ATP5ME UQCR10 DMAC2L COX5B ATP5PF COX5A ATP5PD ATP5F1A ATP5F1C ATP5F1B NDUFA9 NDUFA4 NDUFA5 ATP5PB ATP5F1D ATP5PO UCP1 NDUFB8 NDUFB7 NDUFB10 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260410%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PPP1CA CREB1 GJB1 GRIN1 PPP1CC ARAF RAP1A MAP2K2;MAP2K1 MAPK1 ACTB-1 GRIA2 DRD2 MAPK3 PRKCG DRD4 GRIA3 GRIA4 ACTC1;ACTG2 CAMK2A PPP1R1A ADCY1 PRKCB ADCY8 RAF1 PRKCA GNAS-1 PRKACB-1 GNAI1 PRKACA-1 GRM1 PPP1CB GRM5 RAP1B CAMK4 CALM1 ACTG1 GRIN2A GRIA1 DRD1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260410%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta LRP5 LRP6 CREB3L1 PPIB TNFRSF11A SERPINH1 WNT1 FZD1 BMP1 MBTPS1 P4HB PLOD2 COL1A1 ITPR1 PLOD1 ADAMTS2 P4HA1 SP7 FKBP10 MBTPS2 MIA3 TMEM38B COLGALT1 P4HA2 IFITM5 CRTAP P3H2 P3H1 LOX TNFRSF11B TNFSF11 COL1A2 SERPINF1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260410%WP2369%HOMO SAPIENS Histone modifications SMYD4 KMT5B EHMT1 KMT5A EZH1 SMYD3 SETDB1 KMT5C SETD1B SETD1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SETMAR ASH1L SETD5 H3-3A SETBP1 SETD2 KMT2A EED SETD7 SUV39H1 SET-1 AEBP2 H4-16 H4C1 H4C6 SMYD1 NSD1 KMT2D EZH2 SETD4 KMT2E SMYD2-1 SUV39H2 SETD3 SETD9 SMYD5 SETD6 KMT2B EHMT2 DOT1L KMT2C PRDM2 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260410%WP5146%HOMO SAPIENS Lung pathology of COVID 19 DDX58 IL18 CGAS IL6 IL1B TBK1 IFIH1 CXCL10 CXCL11 MAVS STING1 TLR8 TLR7 CXCL9 CSF2 IRF3 NFKB1 TNF TLR3 CCL13;CCL2 TRANSLATION FACTORS%WIKIPATHWAYS_20260410%WP107%HOMO SAPIENS Translation factors EEF2K EIF3A GSPT2 EIF3C;EIF3CL EIF2B1 EEF1B2-1 EIF4A2 EIF2B4 EIF2B3 EIF4G3 EIF4G1 CLUH EIF4EBP1 EIF2S3;EIF2S3B EIF2AK2 EIF1 EIF4E EEF1G EIF4B EIF5 EIF2B2 EEF1D EIF1AY;EIF1AX EIF3I EEF1A2 EIF3J EIF5B EIF3G ETF1 EIF3E EIF3H EIF3B EIF2B5 EIF3F EIF2S2 EIF2AK1 EEF2 EIF3D EIF2S1 EIF2AK3 EIF4EBP2 EEF1A1 EIF4A1 EIF4H PAIP1 EIF6 EIF5A;EIF5AL1 PABPC1;PABPC3 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260410%WP1434%HOMO SAPIENS Osteopontin signaling MAP3K14 CHUK IKBKB MAP2K2;MAP2K1 RELA NFKB1 MAPK1 PLAU ITGB3 MAPK3 ITGAV MMP9 SPP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGB1 S1PR3 BTK MS4A1 S1PR4 S1PR1 ITGA4 S1PR5 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260410%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE TMPRSS2 ACE2 AGTR1 AGT REN MAS1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260410%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IFNG IL1R1 IL18 SELENBP1 IL1B TLR1 IRAK1 F2R ICAM1 PLA2G7 S100A9 TLR2 NFKB1 F2 FCER1A MYD88 NLRP3 CCR3 HBEGF TIMP1 PIK3CA MMP9 TIMP2 CCL13;CCL2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260410%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development DNER CASP3 DNM1 CDK4 GLI1 LATS2 AKT1S1 LIN54 SPRY2 HIP1 GMNN LIN52 RAD54L2 APP LIN37 TFAP4 RBBP4 RBL1 CSNK1A1 RBL2 NFATC1 SMARCB1 AMPH CDK6 TSC1 RPTOR FOXO1-1 MLST8 SIRT1 TP53 REST CREB1 NEUROG2 H3-3A GSK3B PSENEN DYRK1A PSEN1 CCND1 APH1A LIN9 NCSTN CRY2 BACE1 E2F4-1 MTOR EIF2B5 FGF2 CDKN1B TFDP1 TFDP2 NOTCH1 DLL1 MAPT E2F5 TSC2 HES1 HES5 DEPTOR CASP9 DCAF7 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260410%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease H2AZ2;H2AZ1 HSPB2 DMPK LMNA HP1BP3 HSPB3 CBX5 MYOG NOTCH3 ACTA1 MEF2C MYOD1 LBR LMNB1 DES FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260410%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling CD14 TYROBP NOS2 IL6 CXCL10 PLAT ITGB2 CXCL2;CXCL3;CXCL1-1 FGB FGA IL12B RHOA REL FGG IRAK1 CBLB PLG IFNB1-4 CHUK IRAK4 TICAM1 TIRAP SRC IKBKB AKT1 IRF3 IKBKG RELA TRAF6 NFKB1 ITGAM RASSF5 TLR4 TNF MYD88 LBP TICAM2 FCER1G PIK3CA SYK TLR3 LY96 IRAK2 CCL13;CCL2 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260410%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX12 ALOX5 FADS2 FADS1 PTGS2-2 ALOX15 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260410%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 TNS4 FGFBP1 AREG KRT6B;KRT6C;KRT6A GPR87 KRT17 CDH17 TSPAN8 SPRR1A;SPRR1B ANXA8;ANXA8L1 SLC2A1 S100A2 SPRR3 ST6GALNAC1 SERPINB3;SERPINB4-1 CTSE KRT20 LYZ-1 LGALS4 TFF3-1 KRT15 VSIG2 CTSV;CTSL AGR2 FAM83A AGR3 DHRS9 FAM3D SPINK4 SCEL REG4 PLA2G10;LOC100652777 KRT7 ANXA10 LEMD1 MYO1A PRR15L CST6 LY6D TFF1 CLRN3 VGLL1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism LDLR ABCA1 IDI1 ACAT2 FDPS MVK APOA4 CYP51A1 DHCR24 FABP2 MSMO1 LSS SQLE EBP PMVK SC5D MVD CD36 DHCR7 HMGCR LBR FDFT1 SLC27A4 HMGCS1-1 TM7SF2 NSDHL SAR1B NPC1L1 MGAT1 MTTP ABCG8 ABCG5 DGAT1 APOA1 HSD17B7 APOB PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 PARP1 MIF GLYCINE METABOLISM%WIKIPATHWAYS_20260410%WP1495%HOMO SAPIENS Glycine metabolism MTHFR SHMT2 SHMT1 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260410%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260410%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer TP53 CCNE2 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DBH DISC1 DCTN6 DCTN5 CDK5 YWHAG DCTN2 YWHAB PAFAH1B1 YWHAH DCTN1 DCTN4 YWHAZ YWHAQ DYNC1H1 DDC TH NDEL1 DCTN3 YWHAE PPP2CB;PPP2CA FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260410%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 STAT3 IL10 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260410%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia SMAD2;SMAD3 IL1R1 IL6 IGF1 CEBPB IL6R MSTN MAP1LC3A MAPK11 TNFRSF12A EP300 IL1A RELB AKT1S1 STAT3 MTOR REL SMAD4 PDK1 IL1B IGF1R CHUK IKBKB NFKBIA AKT1 IKBKG RELA NFKB1 RPTOR ACVR2A TNFRSF1A TNF MLST8 JAK1 TRIM63 FOXO3 FBXO32 NFKB2 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260410%WP4022%HOMO SAPIENS Pyrimidine metabolism POLR2H POLR2I POLR2L CAD POLR2J;POLR2J2;POLR2J3 POLR3GL POLR3C POLD3 NT5M POLR3F POLD4 POLR3G POLD1 POLD2 POLE DTYMK NME7 ENPP3 POLR1A POLR1B POLR1C POLR1D POLE2 POLR1E POLE3 POLR1F POLR1H ENTPD1 ENTPD3 NME3 CTPS2 CTPS1 DCTD NME6 CMPK1 CMPK2 UPRT DCTPP1 PNPT1 NME4-1 DUT UCKL1 RRM1 POLR3A DPYS POLR3B POLR3D UPB1 TYMS POLR3H TYMP POLR3K DHODH NT5C POLR2C RRM2B DPYD TK2 UMPS ENPP1 NME1 PRIM2 POLE4 POLA2 POLR3E DCK CDA UPP1 TK1 UCK1 POLA1 PRIM1 RRM2-1 NME2 POLR2A POLR2B POLR2D POLR2E POLR2G CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260410%WP5603%HOMO SAPIENS Caffeine in myocytes MYL2 MYL3 TNNT3 MYH8 MYH6 MYH11 MYL6 MYH13 ACTA1 MYH1 MYH7 ACTB-1 RYR2 ACTC1;ACTG2 TNNI1 TNNI2 TNNI3 RYR1 TPM4 TPM3 TPM2 TNNC1 TNNC2 TPM1 ACTG1 ACTA2 MYLPF MYH3 RYR3 TNNT1 MYL1 TNNT2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260410%WP4707%HOMO SAPIENS Aspirin and miRNAs PTGS1 ABCC4 MVD NFKB1 PDK1 NOS3 VEGFA WNT1 PPARA PTGS2-2 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids CERS1 S1PR3 IGF1R PLD1 S1PR1 AKT1 CERK HIF1A ASAH2 TSC1 NFKB1 SPHK2 MTOR PIK3CA GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260410%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis ERBB4 AP2A1 GAPDH-1 HDAC1 MAP2K2;MAP2K1 MAPK1 HDAC10 MAPK3 AP2B1 GABRR2 PPP2CB;PPP2CA CABIN1 NRXN3 GAD1 GABRB3 GABRB2 GABRB1 AP2A2 GABRG3;GABRG2 SLC6A6 FFAR1 GABRE GNAQ GABRD GABRA2 GABRQ GABRP GABRA1 SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG1 CREBBP MAP1LC3B2;MAP1LC3B-1 SLC6A8 EFNB2 FRMPD3 ADARB1 ZFYVE27 STAT1 SLC6A13 SLC6A12 NR4A1 STAT3 SLC1A7 NETO2 CPEB3 GRM6 NPTN C1QL3 C1QL2 CACNG8 NWD1 MBD5 SNX27 CACNG2 UBQLN4 ATAD1 CAMK2A SYVN1 LHFPL4 SNX14 GNA11 PDIA2 CDH2 GRM3 GRIN2A HOMER1 DLG4 SUMO1 SDCBP GLUL ARC GRIA2 SLC1A1 SLC1A2 SLC1A3 SLC1A6 GRIA3 GRIA4 GRIN2C GRIN2B GLS2 GRIN2D GRIN3B GRIN3A GRIK5 GRIK3 SLC7A11 SH3GL2 GRIK4 GRIK1 GABRR3 GRM1 GRM2 GABRR1 GRM5 GRM4 GRM7 GRM8 ABAT GRIN1 CRTC1 SLC6A1 GRIP1 KIF5C STIM1 SLC32A1 SLC6A11 ORAI1 P4HB NRG1 GRIK2 PRKCA SRC DLGAP3 PICK1 GRIA1 PLCB1 FANCONI ANEMIA%WIKIPATHWAYS_20260410%WP5465%HOMO SAPIENS Fanconi anemia ERCC4 FANCD2 EGFR MCM2 SLX4 BRIP1 USP1 RAD51 ERCC1 UBE2T RAD50 FANCI MRE11 FANCA PTEN RFWD3-2 ATM NBN PALB2 BRCA1 ATR UHRF1 SMARCA4 DCLRE1B UHRF2 FAAP100 REV1 MAD2L2 CENPS-CORT;CORT;CENPS FANCM FANCL BRCA2 FANCE FANCG FANCF CEBPD FANCC CTDP1 HSP90B1 XRCC2 RAD51C FAN1 FAAP24 MEN1 LOC105377022;FANCB CENPX SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1B1 MSRA MSRB2 MSRB3 FMO3 CYP1A2 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260410%WP1403%HOMO SAPIENS AMP activated protein kinase signaling EEF2K SREBF1 PRKAA1 PPARGC1B HMGCR ADIPOR2 ADIPOQ INS;INS-IGF2 FASN CDKN1A LEP STRADB PRKAA2 ACACB ACACA INSR PRKACB-1 RPS6KB2 PIK3CD AKT1 GYS1 TSC1 RPTOR PRKAB2 TP53 PRKAB1 CAMKK1 CAMKK2 CPT1A CRTC2 PIK3C3 PIK3R2 PRKAG1 ADRA1B PIK3R1 PRKAG2 ADRA1A CCNA2-1 PRKAG3 EIF4EBP1 SLC2A4 AKT2 CAB39 LIPE MTOR RPS6KB1 PIK3CB CCNA1 CCNB1 PIK3CG EEF2 GYS2 TSC2 ELAVL1 SLC2A4RG HNF4A STRADA CPT1C LEPR CPT1B PIK3R3 PFKFB3 ADIPOR1 PIK3CA STK11 PLCB1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members CUL1 MAP3K14 GSK3B CLDN6 CREBBP PARP1 EP300 RELB SKP1 DDX58 TFPI2 EIF2AK3 TBK1 MAVS CHUK ZC3HAV1 TIPARP PARP16 RBX1 IKBKB PARP12 NFKBIA PARP10 IKBKG PARP14 ERN1 BTRC NFKB2 NRF2 PATHWAY%WIKIPATHWAYS_20260410%WP2884%HOMO SAPIENS NRF2 pathway GSTT2B;GSTT2 GSTM1;GSTM2-1 FGF13 PTGR1-1 SERPINA1 UGT1A1;UGT1A6 TXNRD3 TXNRD1 GGT1 MGST3 MGST2 SLC6A4 TXN SLC39A9 SLC39A6 SLC6A2 KEAP1 SLC39A5 SLC6A3 SLC39A7 SLC39A2 GSTA3;GSTA5;GSTA1;GSTA2 SLC39A1 SLC5A7 SLC39A4 SLC39A3 PRDX1 BLVRB FTL-1 GSR SOD3 SLC39A11 SLC39A10 SLC39A13 SLC6A6 SLC39A12 PDGFB HMOX1 RXRA GSTA4 NFE2L2 CES5A CES2 CES1 SLC6A8 ABCC3 GSTA3;GSTA1 ABCC4 ABCC2 SQSTM1 SLC2A4 HSP90AA1 SLC6A13 ME1 HBEGF GCLC SLC5A1-1 SLC2A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCC5 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC5A6 ALDH3A1 SLC5A9 CES3 EPHA3 SLC5A3 SLC5A4 SLC2A9 SLC6A5 SLC6A7 MAFF SRXN1 SLC2A5 SLC2A6 SLC2A7 PGD SLC2A8 SLC2A11 MAFG SLC2A10 G6PD SLC2A13 SLC5A11 SLC5A12 SLC5A10 CBR3 SLC2A1 AGER SLC6A9 SLC7A11 HSPA1A;HSPA1B PRDX6 TGFB2 TGFB1 EPHA2 FTH1 SLC39A8 SLC39A14 GSTM4 GSTM3 DNAJB1 SLC6A19 SLC6A1 SLC6A18 SLC6A11 PPARD SLC2A12 GSTP1 SLC5A8 TGFA HGF NRG1 TGFBR2 SLC5A2 SLC6A20 SLC5A5 GCLM EGR1 HSP90AB1 CYP2A13;CYP2A6;CYP2A7-1 CBR1-1 NQO1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260410%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2U1 CYP2R1 CYP2E1 CYP4F22 CYP4X1 CYP2D6;LOC107987479;LOC107987478-1 CYP27C1 CYP2S1 CYP51A1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYB5R2 CYB5R1 CYP4V2 CYB5R4 CYP1B1 CYP11A1 CYP2J2-1 CYP19A1 CYP2F1 CYP7B1 CYP8B1 CYP26A1 CYP27A1 CYP1A2 CYP26B1 CYP20A1 CYP1A1 POR CYB5R3 CYP27B1 CYP46A1 CYP24A1 CYP7A1 CYB5A CYP2W1 CYP4B1 CYP39A1 CYP17A1 CYP2B6 CYP11B1;CYP11B2 CYP2C9;CYP2C19 CYP2C18-1 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260410%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit CD3E CD3D IL2 BCL2 SPN CD86 CD80 CD28 CD27 CD247 CD3G SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260410%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 ADAM17 AVPR1B GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260410%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR PGAM1 HK1 TPI1 ALDOB GK LOC100509620;LOC112267859;AQP7 ENO1 KHK GAPDH-1 GPD2 PGK1 ALDOA GLYCTK GRHPR G6PC1 AQP9 LIPE AGXT AKR1A1 MGLL PNPLA2 SDS PC GPD1 PCK1 FBP1 PFKL GPI CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260410%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling RYR2 ITPR1 CNR1 RYR1 CCKBR GNAI1 TRPC1 CD38 DAGLA RYR3 CCK GNAQ PLCB1 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260410%WP5175%HOMO SAPIENS Disorders in ketone body synthesis BDH1 OXCT1-1 HMGCS2 ACAT1 HMGCL INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260410%WP5120%HOMO SAPIENS Inclusion body myositis NCSTN APP NFKB1 SIRT1 BACE1 PSEN2 MAPT PSENEN PSEN1 NFKB2 MSTN HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260410%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system SMAD2;SMAD3 BIRC5 ACTR1A CSNK2B TPPP HSPA8 MAPK1 SHH GRK2 ISG15 MAPK3 MAPRE1-1 TUBA1C HSPA4 TUBA4A SNCAIP TUBA3E;TUBA3C-1 TUBB4A;TUBB;TUBB8B;TUBB8 FUS FOXP3 PRDX2 AKT1 MAP3K5 PRDX1 TARDBP NR3C1 RAD23B EP400 RAC1 HDAC9 ATP13A2 CYBB MYH9 XRCC6 MAP1LC3A MIF EGFR PRKN DNAJA1-1 EP300 TUBB3;TUBB6 SQSTM1 HSP90AA1 G3BP1 DYNC1I2 DCTN1 VHL GSK3A HSPB1 MDH1 PARK7 MAPK8 ELP3 DLG4 VIM BDNF STUB1 NDUFV1 KALRN ATXN3 CCDC141 CNOT6 NEDD9 MIIP ELP1 GRIA2 BCL2 ARID3A POU5F1;POU5F1B GARS1 PRKCZ SMAD7 RHOT1 SOD1 BAX VCP-1 SP1 SNCA BBIP1 HDAC11 MYD88 APOE ERG OPTN-1 PPP1CA HSF1 GSK3B HTT CTNNB1 DLG2 SGK1-1 KAT5 PROM1 MAPT PRKCE HDAC6 APC AURKA PXN HIF1A UBD ITIH4 CTTN SGK3;C8orf44-SGK3 PTK2B MAP1B CDC20 CSNK2A2 CFTR SIRT2 GRIA1 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260410%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling LYN LCK BTK TEC STAT4 MAP2K2;MAP2K1 EIF4EBP1 FYN MAPK1 STAT5A RELB STAT1 STAT3 IL7R MAPK3 PTPN11 STAT6 HCK MAPK14 JAK2 YES1 FES SRC NFKBIA AKT1 TSLP RELA MAPK9 NFKB1 STAT5B JAK1 CRLF2 NFKB2 RPS6 GAB2 MAPK8 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer RHEB BAD MAPKAP1 GSK3B PIK3R2 PIK3R1 RB1CC1 NRAS EIF4EBP1 TFEB HRAS MTOR PTEN PIK3CB PIK3CG CDKN1B FOXO4 PDK1 KRAS NOS3 TSC2 GRB10 AKT1 RPTOR FOXO1-1 RICTOR MLST8 PIK3R3 FOXO3 ATG13 PIK3CA ULK1 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260410%WP4540%HOMO SAPIENS Hippo signaling regulation PRKAR1B PLCB2 SMAD2;SMAD3 PRKAR1A PRKD3 FGFR4 FGFR1 NF2 PRKAR2B PRKAR2A FLT1 PRKAA1 FLT3 GNAL FLT4 LATS1 LATS2 CDH10 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17 RHOA CDH18 CDH19 TCF7L2 PRKAA2 PLCB3 TCF7L1 IGF1R PRKCZ YAP1-1 CDC42 NTRK1 INSR FGFR3 GNAS-1 NTRK2 GNAI3 PRKACB-1 TEK PRKACA-1 CDH1 GNAI2 KDR RAC1 PRKAB2 PRKAB1 GNAQ EPHA2 WWTR1 NGFR PRKAG1 TCF7 PRKAG2 EGFR PRKAG3 CTNNB1 TEAD1 FGFR2 TEAD2 PDGFRB MST1 TEAD3 TEAD4 KIT PRKCG MTOR PRKCQ CDH9 CDH8 CDH7 CDH6 PRKCH PDGFRA PRKCB LEF1 PRKCE CDH5 PRKCD GNA11 PRKCA CDH4 MET CDH3 CDH2 STK3 PRKCI CDH20 CDH22 CDH24 PLCB4 CSF1R PLCB1 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling EPHX1 HMOX1 MAPK14 MAPK12 MAPK13 NFE2L2 KEAP1 MAPK11 ABCC6 GCLM CES1 ABCC3 ABCC4 ABCC2 FOS NQO2 GSTP1 GCLC JUN ABCG2 NQO1 SRXN1 MAPK8 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260410%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY4 P2RY2 LTB4R ADORA3 P2RY1 ADORA2B ADORA2A LPAR4 LPAR6 ADORA1 P2RY6 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260410%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260410%WP2333%HOMO SAPIENS Trans sulfuration pathway MTR-1 CBS;CBSL AHCY CSAD MAT2B CTH MPST DNMT1 GCLM GOT1-1 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260410%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization TGFB1 TGFB3 CCR1 IL4R CD4 CSF2 IFNGR1 IFNGR2 CCR5 IL2 CCR7 IL4 CCR4 IL18R1 CCR3 CCR2 CCL4L2;CCL4L1;CCL4 IL12B IL12A IL12RB1 IL12RB2 IFNG CXCR4 CD40LG CXCR3 CCL3L1;CCL3L3;CCL3;CCL18 IL5 CD28 TGFB2 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer MACROH2A1 E2F1 MED1 JAG1 CSRP2 CCND1 CDK4 CDK8 CTNNB1 CDH1 RB1 PMAIP1 SOX4 TULP3 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP69%HOMO SAPIENS T cell receptor signaling CD3E CD3D DBNL MAP3K8 MAP3K7 NCK1 CD4 GRAP2 CD247 ITK RIPK2 CD8A MAP2K2;MAP2K1 LCP2 ICOS MAPK1 HRAS MAPK3 PSTPIP1 VAV3 JUN MAPK14 FYB1 WAS GRB2 CDC42 SOS1 PDPK1 RAF1 CHUK ATF2 NFATC1 IKBKB NFKBIA AKT1 IKBKG CRKL TRAF6 NFKB1 FOS CD28 GAB2 VAV1 ZAP70 CREB1 LAT LCK MAP3K14 CRK CARD11 BCL10 MALT1 PIK3R2 PIK3R1 CBL MAP4K1 FYN SKAP1 PTPN11 SH2B3 PRKCQ REL ITPR1 CBLB PRKCD PLCG1 RELA MAPK9 PTK2B NFATC2 SHC1-1 CD3G PAK1 MAPK8 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL23A IL1B JAK2 CXCL8 IL17F IL17A CXCL2;CXCL3;CXCL1-1 TNF CCR6 STAT3 IL17RC CCL20 IL22 IL23R IL12B TYK2 IL12RB1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260410%WP34%HOMO SAPIENS Ovarian infertility SMAD2;SMAD3 CREB1 MLH1 PGR CEBPB SMPD1 LHCGR NR5A1 CDK4 NRIP1 INHA ESR2 RAD51 PRLR MTOR CYP19A1 FIGLA GDF9 FSHR DMC1 ATM FMR1 TBP ZP3;POMZP3 CDKN1B NCOR1 VDR TSC2 ZP2 BMPR1B MSH5 AKT1 SYNE2 CCND2 TSC1 GJA4 EGR1 DAZL PTGER2 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260410%WP1984%HOMO SAPIENS Integrated breast cancer pathway MYC CHEK2 MYCBP2 SMAD2;SMAD3 E2F1 BARD1 MMP1 BAD PLK1 CDC25A CDC25B MSH6 BMPR2 HDAC1 MSH2 TFPI ARAF DAG1 CDK4 NOXA1 RRAS ODC1 PML MAPK1 RAD51 HMGCR DHTKD1 JUN BRAF MYT1 RAD54L KRAS GADD45A SELENOK FOSL1 IRS1 AKT1 BRCA2 TSC1 FOXO1-1 NCOA3 SIRT1 RAC1 JAK1 TP53 MDM2-2 PIAS1 JAKMIP1 CREB1 RHEB SMAD6 CDK2 RALA-1 PIK3R2 AHR EGFR RAP1A RASGRP3 EP300 CSNK1D STAT1 ESR1 WEE1 MTOR CYP19A1 ANXA1 NF1 PPP4R3A PPP4R3B SMARCA4 GSK3A RB1 ZNF655 CASP9 ZMIZ1 STK11 MAX PAK1 CASP8 CASP3 FADD PKIA CDK7 TRADD HIPK2 SMAD1 EDAR BCL2 CHEK1 NAB1 MAP3K7CL ZMYND8-1 ALKBH1 RALGAPA1 CCNB1IP1 PLK3 ATR ERAL1 FOSL2 FER PIGR CDC42 PHB USP38 BAK1 SMAD7 IMPA1 RASGEF1A CHUK DCAKD ITPKC USP15 BAX USP16 SP1 USP21 FILIP1 CDH1 NFKB1 TAB1 BID FAU RPP38 CCND1 NUP85 CTNNB1 CERK AR BMPR1A RHO GRN RAD50 MRE11 ATM PTEN TGFBR1-1 BRCA1 SMAD4 TGFBR2 TSC2 MAP3K13 AURKA GDI1 TPR XRCC3 ABL1 VEGFA ATF1 BLM UBE2F BACH1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260410%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer SMAD2;SMAD3 NRP1 FLT1 MAP2K2;MAP2K1 MAPK1 CHD1 SEMA3A MAPK3 MMP2 MMP9 PLXNA1 CHD2 SNAI1 EGF AKT1 SLC39A4 PLXNA4 NFKB1 KDR RAC1 CCNE1 CCN2 COL1A2 BCAR1 TGFB2 TGFB3 CDK2 PTK2 CCNE2 EGFR AKT3 PLXNA2 RELB AKT2 PECAM1 REL TGFBR1-1 CDKN1B SMAD4 COL1A1 HGF SNAI2 TGFBR2 CDH5 TGFBR3 MET GSK3A SRC RELA VEGFA NFKB2 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260410%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone CASR GRM1 GRM2 GPRC5B GRM5 GPRC5A GRM3 GRM4 GPRC5C GRM7 GRM8 GABBR1 GPRC5D GABBR2 GRM6 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260410%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2H GTF2H4 POLR2I TAF12 TAF13 CDK7 POLR2J;POLR2J2;POLR2J3 ERCC3 TAF7 TAF6 POLR3B POLR3D POLR3H POLR3K POLR2C ERCC2 GTF2B ILK TBP MNAT1 POLR3E POLR1A POLR1B POLR1D POLR1E GTF2F2 TAF5 GTF2A2 TAF9 GTF2E1 GTF2E2 GTF2H2C;GTF2H2C_2;GTF2H2 POLR2A CCNH POLR2B POLR2E POLR2F GTF2H1 POLR2G GTF2H3 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260410%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy ANK3 KCNQ1 FGF13 KCNQ2 KCNQ3 FGF12 NEDD4L AKAP5 DAG1 STX1A PRRT2 BACE1 NEDD4 SCN8A SCN2A SCN4B SNAP25 CAMK2A ITPR1 PRKCE PRKACA-1 CALM1 VAMP2 RAB1A TRAPPC3 RAB11A TRAPPC2;TRAPPC2B GIGYF1 TRAPPC6B KCNQ4 KCNQ5 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome FNDC8 TCAP PNMT GRB7 CCL23;CCL15 PEX12 AP2B1 MMP28 CCL11 LIG3 ACACA CCL5 RPL23 HNF1B PGAP3 CCL14 PIGW CCL16 DHRS11 CCL13;CCL2 CWC25 SLFN11;SLFN13 AATF IKZF3 STARD3 CISD3 RDM1 LHX1 LASP1 ARL5C C17orf98 C17orf50 GPR179 UNC45B DDX52 DUSP14 LYZL6-1 MRPL45 TEC SRCIN1 RAD51D SLFN14 SOCS7 ZNF830 SLFN5 CCL1 GGNBP2 FBXO47 MLLT6 CCT6B CACNB1 FBXL20 NEUROD2 PPP1R1B MIEN1 ZNHIT3 CCL4L2;CCL4L1;CCL4 C17orf78 ASIC2 GAS2L2 HEATR9 TAF15 RASL10B ERBB2 PCGF2 SYNRG EPOP MYO19 MED1 PLXDC1 NLE1 ARHGAP23 TADA2A STAC2 SLFN12L;SLFN12-1 CDK12 PIP4K2B RFFL SLC35G4;SLC35G5;SLC35G3;SLC35G6 CCL3L1;CCL3L3;CCL3;CCL18 TMEM132E CCL8 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260410%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 MYC UPF1 RET DUX4;DUXA MYOG MYF5 PAX7 ADRB2 PPARGC1A EP300 ESR2 MYOD1 TRIM63 FBXO32 VEGFA CDKN1A SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260410%WP4658%HOMO SAPIENS Small cell lung cancer CASP8 MYC TRAF1 CASP3 TRAF4 E2F1 TRAF5 CDKN2B BIRC7 BIRC2 LAMC3 BIRC3 LAMC2 LAMC1 NFKBIB APAF1 E2F2 CDK4 E2F3 ITGB1 BCL2 ITGAV CDKN1A ITGA3 ITGA2 TRAF2 SKP1 LAMA5 ITGA6 LAMA2 LAMA1 LAMA4 LAMA3 BAK1 CHUK GADD45B LAMB3 GADD45A LAMB2 GADD45G LAMB1 BAX IKBKB NFKBIA PIK3CD AKT1 IKBKG TRAF3 CDK6 BCL2L1 TRAF6 NFKB1 CCNE1 BID TP53 PTGS2-2 RXRB RXRA RXRG NOS2 FN1 CDK2 PTK2 PIK3R2 CCNE2 PIK3R1 CCND1 AKT3 ITGA2B AKT2 DDB2 CKS1B RARB POLK PTEN PIK3CB FHIT CDKN1B COL4A2 COL4A1 COL4A4 COL4A3 CKS2 COL4A6 COL4A5 LAMB4 RB1 RELA PIK3R3 ZBTB17 CDKN1C CASP9 PIK3CA CYCS-1 MAX MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis MOCS1 GPHN XDH AOX1 SUOX MOCS2 MTARC2 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP3941%HOMO SAPIENS Oxidative damage response TRAF1 CR2 CASP3 C2 C1QC BAD APAF1 C5 PCNA C5AR1 C3AR1 NFKBIE BCL2 CDKN1A MAP2K4 MAP3K1 TRAF2 C1S CDKN1B C1R MAPK10 MAPK13 CDC42 BAK1 GADD45A BAG4 TRAF3 MAP3K9 TDP2 TRAF6 C1QB NFKB1 TNF TNFRSF1B LOC110384692;C4A;C4B_2;C4B CDKN1C CASP9 CYCS-1 TNK2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260410%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAD ALAS2 ALAS1 FECH UROD UROS HMBS CPOX PPOX NEPHROGENESIS%WIKIPATHWAYS_20260410%WP5052%HOMO SAPIENS Nephrogenesis RSPO1 WNT3A WNT4 JAG1 TCF21 FGF8 NOTCH2 GREB1L WNT9B MEIS1 FGF20 ALDH1A2 RSPO3 OSR1 BMP7 FOXD1 PAX2 SIX2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260410%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A2 SLC6A19 SLC3A1 SLC36A2 SLC1A1 SLC6A20 CLTRN SLC7A7 SLC7A9 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260410%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAP2K2;MAP2K1 CYP2E1 MAFK MAFG NFE2L2 MAFF MAPK8 SP1 SIGNALING LIPIDS%WIKIPATHWAYS_20260410%WP5584%HOMO SAPIENS Signaling lipids ALOX12 PTGDS LTC4S LTA4H CYP4F3;CYP4F2;CYP4F12;CYP4F11 PLA1A CYP7B1 GPX4 CYP8B1 CYP27A1 FADS2 CYP7A1 PLA2G1B EPHX2 PTGES ALOX5 PRXL2B TBXAS1 CYP2B6 CYP2C9;CYP2C19 PTGS2-2 HPGD CBR1-1 ALOX15 PLCB1 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5292%HOMO SAPIENS Glycosphingolipid metabolism A3GALT2 B4GALT3 GALC ARSA B4GALT4 GAL3ST1 GBA UGT8 GLA GBA2 ST3GAL5 B4GALT5 NEU3 NEU4 B4GALT6 UGCG B3GALT2 B3GALT1 B3GNT5 B4GALNT1 A4GALT ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260410%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase COX8A CYP2J2-1 CYP2C9;CYP2C19 GSTP1 COX5A EPHX2 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260410%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260410%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT16 WNT4 FZD4 LRP5 LRP6 CTNNB1 WNT9B WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 FZD1 RHOA WNT10B WNT10A FZD3 MAPK10 NPHP3 WNT3A FZD2 FZD5 WNT5A WNT7B FZD7 FZD6 FZD9 INVS FZD8 WNT7A WNT2B MAPK9 WNT5B MAPK8 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260410%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MYC AXIN2 SMAD2;SMAD3 CASP3 BIRC5 BAD MSH6 MSH2 ARAF MAP2K2;MAP2K1 MAPK1 BCL2 MAPK3 CDKN1A RHOA JUN BRAF TCF7L2 MAPK10 TCF7L1 TBK1 CSNK1A1 KRAS BAK1 RAF1 EXOC2 GADD45B GADD45A GADD45G BAX AKT1 RAC3 FOS RAC1 RALGDS TP53 PTGS2-2 TGFB2 TGFB1 TGFB3 MLH1 GSK3B RALA-1 TCF7 CCND1 AKT3 APPL1 CTNNB1 PMAIP1 AKT2 DDB2 POLK REL TGFBR1-1 DCC SMAD4 RALB NTN1 AXIN1 TGFBR2 LEF1 APC MSH3 MAPK9 BCL2L11 APC2 CASP9 CYCS-1 BBC3 MAPK8 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260410%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway CASP8 POLR2H CASP10 POLR2L FADD CXCL10 POLR3GL TRADD NFKBIB CASP1 POLR3C POLR3F POLR3G ISG15 ATG5 TBK1 POLR1C CCL5 IKBKE POLR1D IFNB1-4 CHUK AIM2 IKBKB NFKBIA IRF3 IKBKG IRF7 NFKB1 RNF125 RIPK1 CYLD IL33 NLRX1 IL18 IL6 PYCARD ATG12-1 POLR3A POLR3B POLR3D POLR3H POLR3K CCL4L2;CCL4L1;CCL4 DDX58 POLR3E TREX1 CGAS IL1B ADAR MAVS STING1 RIPK3 TRIM25 RELA ZBP1 POLR2E POLR2F TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260410%WP691%HOMO SAPIENS Tamoxifen metabolism CYP1A1 CYP2E1 FMO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1B1 SULT2A1-4 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FMO3 CYP1A2 JOUBERT SYNDROME%WIKIPATHWAYS_20260410%WP4656%HOMO SAPIENS Joubert syndrome MYO5A CPLANE1 TMEM231 TMEM138 TMEM17 ATF4 RP2 PARP1 TMEM216 ZNF423 PDE6B AHI1 TCTN3 PDE6A TCTN2 TMEM237 TCTN1 UNC119 CC2D2A SHH CEP104 ARL3 DVL1 DVL3 RAB8A OFD1-1 RHOA ARL13B TMEM67 B9D1 PDE6D NPHP3 BBS2 NEK8 BBS1 MYO6 CETN2 TTC8 KIAA0586 MKS1 CEP41 B9D2 ANKS6 FLNA NPHP1 RHEB RAD50 MTOR MRE11 ATM KAT5 INPP5E INVS CEP164 CEP120 CETN1 CEP97 CCP110 ARMC9 ARR3 BBS9 RPGRIP1L BBS7 ARL2 PCNT BBS5 RAB3IP CSPP1 CEP290 NIN BBS4 PIBF1 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer B2M HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PDCD1LG2 VTCN1 TIGIT CD276 FAP CXCL12 ICOS SHH FAS LGALS3 TNFRSF9 TNFSF4 ARG1 TNFSF9 LGALS1 CTLA4 CCL17 CCL22 IL13 CD28 ENTPD1 IDO1 TGFB2 PDGFB TGFB1 TGFB3 PDGFD PDGFC IL6 PDCD1 PDGFA IL10 IL4 CD226 VEGFB VEGFC VEGFD VDR CXCR4 CD40LG TNFRSF4 FASLG LGALS9C;LGALS9;LGALS9B PGF CD86 NT5E CD40 CD80 HAVCR2 VEGFA CD274 PVR VSIR SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260410%WP615%HOMO SAPIENS Senescence and autophagy in cancer SMAD2;SMAD3 E2F1 LAMP1 FKBP8 ING1 MAP1LC3C IFI16 CREG1 CDC25B RSL1D1 RB1CC1 IGFBP5 MAP2K2;MAP2K1 PLAT PCNA MAPK1 HRAS AKT1S1 MAP2K3 CDKN1A JUN BRAF MAPK14 ATG5 IGF1R BMP2 RAF1 CXCL8 SLC39A2 SLC39A1 SLC39A4 SLC39A3 MLST8 ATG13 TP53 MDM2-2 PIK3C3 SH3GLB1 IL6 ATG3 UVRAG FN1 IL6R ATG10 AMBRA1 ATG14 ATG12-1 MAP1LC3A ATG16L1 MAP1LC3B2;MAP1LC3B-1 ATG7 CXCL2;CXCL3;CXCL1-1 SQSTM1 IRF1 MTOR RNASEL CDKN2A IGFBP3 IFNG COL1A1 IL1B IRF5 COL3A1 INHBA CXCL14 RB1 CCL3L1;CCL3L3;CCL3;CCL18 IL3 TNFSF15 CEBPB KMT2A IL1A BCL2 INS;INS-IGF2 ING2 MMP14 BECN1 LAMP2 IFNB1-4 SPARC IRF7 IL24 SERPINE1 ULK1 TGFB1 IGF1 GSK3B BMI1 THBS1 VTN COL10A1 CD44 PTEN SMAD4 CDKN1B IGFBP7 GSN GABARAPL2 SERPINB2 IL6ST SRC PLAU GABARAP FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260410%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis EEF2 PRKAA2 EEF2K TSC2 PRKAG1 PRKAG2 CSN1S1 EIF4A2 PRKAG3 EIF4G1 PRKAA1 CSN3 EIF4E RPTOR CSN2-1 MLST8 PRKAB2 MTOR PRKAB1 RPS6KB1 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260410%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling MYC RXRA PRKAA2 HLA-DRA VDR TSC2 GSK3B CYP24A1 IL10 AKT1 RELA PDHA1 TSC1 CD86 PFKFB4 CD80 MTOR HK3 PIK3CA IL12A LDHA NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260410%WP2882%HOMO SAPIENS Nuclear receptors meta pathway MYC GSTM1;GSTM2-1 FGF19 FGF13 PTGR1-1 EHHADH-1 SERPINA1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GCC1 CDK4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CDK1 UGT1A1;UGT1A6 SREBF1 NR1H3 GGT1 SCD FASN PPARA JUN TXN SLC39A9 SLC39A6 SLC39A5 SLC39A7 SLC39A2 SLC39A1 IRS2 SLC39A4 PRDX1 SLC39A3 GSR NR3C1 SULT2A1-4 SOD3 SLC39A11 SLC39A10 SLC39A13 IL17B ALOX5AP SLC6A6 SLC39A12 ALAS1 CAP2 PDE4B ABCB1 AHR EGFR ABCB4 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NRIP1 SCP2 CYP1B1 SLC6A8 EP300 ABCC3 ABCC4 ABCC2 SLC10A1 SQSTM1 HSP90AA1 AIP STAT3 ME1 ARNT ESR1 BAAT GCLC CYP8B1 CDC37 CYP1A2 CYP1A1 AHRR SLC27A5 IGFBP1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SNAI2 VDR CYP7A1 PLTP ABCG8 ABCG5 APOA2 APOA1 APOC3 TNF APOA5 CYP2B6 CYP2C9;CYP2C19 PGD AGER SLC6A9 BAX SP1 PRDX6 HSPA1A;HSPA1B CCL20 TGFB2 TGFB1 FTH1 SLC39A8 SLC39A14 GSTM4 GSTM3 CCND1 SLC19A2 PPARD SLC2A12 GSTP1 TGFA KLK15 CPT2 ACADM HGF NRG1 TGFBR2 TGFBR3 MFGE8 GCLM MYOF PCK1 IP6K3 NFKB2 HSP90AB1 GSTT2B;GSTT2 BIRC2 BIRC3 TXNRD3 TXNRD1 IL12B IL12A MGST3 MGST1 MGST2 SLC6A4 GADD45B SLC6A2 KEAP1 SLC6A3 GSTA3;GSTA5;GSTA1;GSTA2 SLC5A7 NCOA1 BLVRB FOXO1-1 FTL-1 NCOA3 PTGS2-2 CPT1A CCL13;CCL2 PDGFB HMOX1 RXRA GSTA4 NFE2L2 CES5A CES2 CES1 GSTA3;GSTA1 IL2 SLC2A4 SLC6A13 SLC7A5 HBEGF POLK B3GNT5 SLC5A1-1 SLC2A2 IFNG NCOA6 IL1B ACOX1 HES1 ACAA1-1 ABCC5 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC5A6 ETNK2 ALDH3A1 ZIC2 SLC5A9 CES3 EPHA3 SLC5A3 SLC5A4 CDKN1C SLC2A9 SLC6A5 TNFAIP3 SLC6A7 AKAP13 MAFF THBD EPB41L4B SRXN1 CUL1 SLC2A5 ARL5B KAT2B GPAM RGS2 SLC2A6 DNER SLC2A7 ENC1 SLC2A8 ANKRD1 SLC2A11 TNS4 SLC2A10 MAFG PDK4 SLC2A13 G6PD SRGN IL11 SLC5A11 FGFBP1 SLC5A12 EDN2 SLC5A10 TSC22D3 CBR3 NR0B2 SERPINB9 NAV3 ADGRF4 CDC42EP3 SCNN1A PMP2 PPARGC1A ANGPTL4 PTGES3-1 SLC26A2 ABHD2 NR1I3 AMIGO2 NR1I2 POU5F1;POU5F1B PRRG4 FGD4 SEC14L1 GPR153 SERTAD2 STOM LRRC8A PPP1R14C CAVIN2 SLC2A1 PLK2 DNAJC15 KTN1 BHLHE40 S100P SPRY1 CPEB4 ACKR3-2 PSMC5 SLC7A11 FKBP5 SLC27A1 EPHA2 NCOA2 DNAJC7 FABP1 PTPA DNAJB1 SLC6A19 SMARCA1 SLC6A1 SLC6A18 SLC6A11 SRPX2 SLC5A8 SMC1A NR1H4 CDKN1B JUNB SLC5A2 SLC6A20 SLC5A5 SERPINB2 SRC EGR1 SLCO2B1 JUND CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2A13;CYP2A6;CYP2A7-1 CBR1-1 NQO1 ALSTROM SYNDROME%WIKIPATHWAYS_20260410%WP5202%HOMO SAPIENS Alstrom syndrome CEP192 IFT81 BLOC1S4 PTCH1 VCPIP1 BLOC1S6 GPR161 HSPB11 BLOC1S1 STX5 SNAPIN PIFO RFX2 DTNBP1 RFX3 RFX1 SMO E2F4-1 TUBG1 ARMCX5-GPRASP2;GPRASP2 DNM3 NSFL1C RILPL1 IFT74 MYO5B RABL2A;RABL2B TFDP2 VCP-1 IFT172 CEP19 ALMS1 IFT27 ACTN4 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260410%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 SELL CD69 TBX21 CXCL12 BTLA HSPA8 PTCRA ICOS ITGB2 CCR7 ISG15 C3-1 ZEB2 IL12A BACH2 FCRL5 CD1D SLAMF7 AICDA CXCR5 BCL6 EBI3 CRP MAF CD79A LOC102723996;ICOSLG FOXO1-1 IRF8 CCL19 CD82 TLR4 GPR183 CCL21 IFNAR2 SYK BLNK IRF4 CR2 BCR TMSB10 MS4A1 IL6 PDCD1 ETS1 CD19 TLR7 IL10 CD22 STAT5A IL2 IL4 SH2D1A PTPRC TNFSF13B PAX5 IFNG XBP1 PRDM1 CXCR4 CR1L;CR1 CD40LG CXCL13 MFGE8 IFIT2 TNF CD40 IL21 CD80 LOC110384692;C4A;C4B_2;C4B ITGAX IFITM3;IFITM2;IFITM1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260410%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt SST GHRH GNRH1 IGF1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260410%WP4753%HOMO SAPIENS Nucleotide excision repair GTF2H4 ERCC4 CDK7 ERCC3 XPA POLD3 POLD4 PCNA POLD1 ERCC1 ERCC8 POLD2 ERCC2 ERCC6 POLE DDB2 RFC5 RPA3 RFC3 RPA1 RFC4 RPA2 POLE4 LIG1 DDB1 MNAT1 RFC1 RFC2 CUL4A POLE2 POLE3 XPC RBX1 CETN2 CUL4B RAD23A RAD23B GTF2H2C;GTF2H2C_2;GTF2H2 CCNH GTF2H1 ERCC5;BIVM-ERCC5 GTF2H3 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism A3GALT2 ST8SIA1 SLC33A1 ST8SIA3 B3GALT4 ST8SIA5 ST3GAL1 ST3GAL2 ST6GALNAC6 ST3GAL5 FUT1 B3GALT1 B4GALNT1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer GZMH;GZMB-1 MYC PRF1 IFNG TIGIT CCL5 GATA2 BMI1 CD96 NCR3LG1-1 KLRC4-KLRK1;KLRK1 CSF2 CCL1 FOXO1-1 CCL3L1;CCL3L3;CCL3;CCL18 TNF CD226 NCR1-1 CCL4L2;CCL4L1;CCL4 ADAM10 ADAM17 FCGR3A;FCGR3B PVR CCL13;CCL2 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260410%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis RXRA CREB1 IL6 CEBPA CEBPB INSR PCK2 IRS1 NRIP1 IRS2 PPARGC1A CEBPD FOXO1-1 SLC2A4 ADIPOQ NR3C1 TNF LPIN1 LEP PPARG MAPK8 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260410%WP2197%HOMO SAPIENS Endothelin pathways GNG13 CAD ADRA1A GNB5 NPY1R GNA15 MAP2K2;MAP2K1 MAPK1 NPY EDNRA EDNRB ECE1 PTGIR NOS3 RAF1 PRKCA GNAS-1 RAMP1 ATP2A2 ADRB1 CNN1 GNAI1 RIIAD1 MYLK CALCA CALCRL EDN1 CALM1 ADCY10 MYL1 PLCB1 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260410%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 LDLR CETP APOA4 LCAT LPL EPHX2 LIPC GHR PLTP APOA2 APOA1 USF1 PCSK9 GPIHBP1 LDLRAP1 APOB DNA MISMATCH REPAIR%WIKIPATHWAYS_20260410%WP531%HOMO SAPIENS DNA mismatch repair RFC1 RFC2 EXO1 MLH1 POLE2 POLE3 MSH6 MSH2 PMS2 POLD3 POLD4 PCNA POLD1 POLD2 POLE RFC5 RPA3 RFC3 RPA1 RFC4 RPA2 POLE4 LIG1 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260410%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IFNG IL23A JAK2 IL17F IL17A CSF2 STAT4 STAT5A STAT1 TLR4 STAT5B TNF STAT3 IL22 RORC IL12B TYK2 IL12RB1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260410%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NMNAT1 NADSYN1 TDO2 KMO KYNU QPRT HAAO AFMID BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260410%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation LDLR ABCG8 ABCG5 FXR1-1 FGF19 MAPK1 FGFR4 SLC10A1 SLC10A2 MAPK3 CYP7A1 ABCB11 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260410%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC2A2 PGM1 SORD TPI1 HK1 ALDOB KHK GLYCTK ALDH1A1 G6PC1 FBP1 PFKL GPI SLC5A1-1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway TGFB1 CAP2 NFE2L2 AHR EGFR UGT1A1;UGT1A6 CYP1B1 PTGES3-1 EP300 IL2 HSP90AA1 AIP SLC7A5 ARNT POLK IL12B IL12A JUN CDC37 CYP1A2 IFNG CYP1A1 AHRR CDKN1B IGFBP1 IL1B MGST1 JUNB HES1 SERPINB2 BAX SRC GSTA3;GSTA5;GSTA1;GSTA2 MYOF NCOA1 ALDH3A1 TNF CES3 JUND IL17B NQO1 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260410%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GRIA3 PLCB2 GRIA4 PLCB3 PDK1 ITPR1 GNA11 GNA14 TRPC3 GNA15 GRM1 HOMER3 CA8 GRIA2 ATP2B2 PRKCG RYR3 PLCB4 CACNA1A GRIA1 GNAQ PLCB1 COPPER METABOLISM%WIKIPATHWAYS_20260410%WP5189%HOMO SAPIENS Copper metabolism SLC11A2 ATP7B ATP7A SLC31A1 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260410%WP545%HOMO SAPIENS Complement activation C1S C1R C2 C1QC CD55 MASP1 CFB C5 C6 CFP C7 C1QB C9 MASP2 CFD C3-1 C8G C8A LOC110384692;C4A;C4B_2;C4B C8B METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260410%WP5355%HOMO SAPIENS Metabolic epileptic disorders SLC2A5 PGAM1 HK2 ECHS1 GCK GLUD1;GLUD2 HK1 TPI1 ALDOB ALDH7A1 PGAM2 GPT ENO1 GCDH GAPDH-1 PGK1 ALDOA GLDC BTD PFKM GOT1-1 AMT HLCS PSPH CBS;CBSL G6PC1 SHMT2 SHMT1 DHTKD1 MPC1 LDHA PKM ACO1 SLC2A1 ENO2 ENO3 PFKP SLC25A15 CPS1 GLS2 ARG1 ASL PC ALDOC SFXN1 SLC25A1 ASS1 OTC HADH SQOR LDHA;LDHC GOT2-1 GPHN AADAT MOCS3 XDH MPC2 AASS SLC1A5 PHGDH FBP2 SLC7A2 LDHB SPCS1 DLAT CTH LDHAL6B PKLR ACAT1 PSAT1 GAMT GATM PDHA1 SLC2A4 ETHE1 SUOX SLC25A5 SLC2A2 MDH2 CDO1 MOCS2 DLD MOCS1 PCK1 FBP1 MDH1 PFKL HK3 GPI HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260410%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells VAV1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TYROBP IFNG LAT PTPN2 ITPR1 NLRP7;NLRP2 PRKCA CSF2 PLCG1 FYN LCP2 TNF RAC1 ELF3 SYK PRKCQ PTPN6 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260410%WP4725%HOMO SAPIENS Sphingolipid metabolism overview GBA SMPD1 UGT8 CERS3 DEGS1 CERK SGMS1 GBA2 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGCG CERS4 ASAH1 SGPL1 CERS6 PLPP3 PLPP2 KDSR PLPP1 CERS1 CERS2 SPTLC1 DEGS2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260410%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates USP28 MYC PGAM1 U2AF2 SLC2A1 OTUD6B HK2 OTUD7B PGK1 VHL AKT1 HIF1A FOXO1-1 G6PC1 FBP1 KDR MTOR VEGFA USP7 PIK3CA OTUB2 USP37 USP44 LDHA NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260410%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2-2 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260410%WP5166%HOMO SAPIENS Glyoxylate metabolism GOT2-1 SLC26A1 PXMP2 HAO1 HOGA1 PRODH2 ALDH4A1 AGXT DAO GRHPR LDHA HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260410%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 MYC TP63 FOXI3 LRP5 PDGFA CCND1 PTCH1 CTNNB1 ITGB1 FGFR2 GLI1 GTPBP4 GLI2 SHH EDAR SMO RUNX2 FZD1 LAMA5 FGF1 BMP4 WNT5A LEF1 PDGFRA INHBA SNAI1 NCAM1 GJB6 EDA CDH1 CCND2 NFKB1 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260410%WP2007%HOMO SAPIENS Iron metabolism in placenta TFRC ACO1 SLC11A2 HAMP TF HEPHL1 IREB2 TFR2 MCOLN1 STEAP3 SLC40A1 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260410%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade CD3E HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PDCD1LG2 CD3D IFNG HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 BATF ZAP70 NFATC4 LCK PDCD1 NFAT5 NFATC3 NFATC1 CD8B;CD8B2 CD8A NFKB1 NFATC2 STAT3 PTPN11 CD274 JUN CD3G SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260410%WP2267%HOMO SAPIENS Synaptic vesicle pathway CLTA AP2A1 DNM1 SLC38A1 DNM2 AP2S1 AP2B1 DNM3 SLC1A3 SNAP25 SLC6A4 DNM1L SLC25A4 VAMP2 STX2 SLC18A3 CLTCL1 AP2A2 SLC17A6 SLC17A7 RIMS1 SLC18A1 UNC13C SYP SYN3 SYN2 SLC22A3 ATP1A2 STX1A CPLX2 RAB3A CLN8 CPLX1 CPLX3 SLC32A1 STX3 SLC17A8 SYT1 SLC18A2 UNC13B UNC13A SYN1 AP2M1 NAPA NSF PARK7 STXBP1 CACNA1B CACNA1A CLTC HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260410%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming NOL9 DNMT3A TET2 CREBBP HDAC2 HDAC1 PIP4K2A IRS1 EP300 EZH2 FTO ANKRD13C DNMT1 IFITM3;IFITM2;IFITM1 GGT6 CADM1 YTHDF3 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260410%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells GPR143 PLCB2 CREB1 GNA15 ARRB1 ARRB2 TYR MC1R PMEL TYRP1 ASIP ADCY4 MLANA PLCB3 ITPR1 PRKCB GNAS-1 PRKACB-1 MITF ADCY2 PRKACA-1 ADCY9 POMC VEGFA PLCB4 SERPINF1 DCT GNAQ PLCB1 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260410%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways BAD NEUROD1 HDAC2 HDAC1 ELK1 MAP2K2;MAP2K1 PRKAA1 MAPK1 MBP HMGCR MAP2K7 HRAS SREBF2 AKT1S1 HMGCS1-1 SIN3A MAPK3 MAP2K4 MAPK10 PRR5L CYP46A1 RAF1 EGF IKBKB AKT1 PIK3CD NR1H2 TSC1 RPTOR RPS6KA5 MLST8 GABRB3 PRKAB2 GABRB2 PIK3R6 GABRB1 PRKAB1 GABRG3;GABRG2 GABRE GABRD REST GABRA2 GABRQ GABRP CREB1 SLC12A2 GABRA1 IL6 SLC12A5 GABRA6 RHEB HMGCS2 GABRA5 GABRA4 GABRA3 GABRG1 PIK3R4 PIK3R2 PIK3R1 PRKAG1 PRKAG2 EGFR PRKAG3 EIF4EBP1 EIF4E MTOR RPS6KB1 ABCG4 IL1B RAB3GAP1 DEPTOR PIK3R3 PIK3R5 CASP7 MAPK8 CASP8 CASP3 BDNF MAP3K10 CYP51A1 PPARGC1A AHI1 DHCR7 BCL2 PRKAA2 BNIP3 OPA1 NTRK2 BAX SP1 BCL2L1 GRM1 ABCG1 NFKB1 BID APOE ABCA1 HTT AKT3 RAB3A AKT2 CKB KIF5A HAP1 PTEN PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B ITPR1 TSC2 MAPK9 RICTOR BCL2L11 PIK3CA CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260410%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ABCA1 MYLIP FADS1 GGPS1 ACSL1 HMGCS2 IDI1 ACAT2 FDPS MVK CYP51A1 ACSL3 DHCR24 MSMO1 LSS SQLE SOAT1 EBP SOAT2 PMVK SREBF1 SC5D NR1H3 MVD DHCR7 HMGCR LBR FDFT1 SREBF2 HMGCS1-1 SCD FASN TM7SF2 NSDHL CYP27A1 FADS2 ACSL4 ELOVL5 ELOVL2 CYP46A1 ACOT2;ACOT1 NR1H2 ABCG1 CH25H HSD17B7 ELOVL4 ELOVL3 SICKLE CELL DISEASE%WIKIPATHWAYS_20260410%WP5604%HOMO SAPIENS Sickle cell disease IL18 IL1B TLR4 HBA2;HBA1 HBD;HBB FELBAMATE METABOLISM%WIKIPATHWAYS_20260410%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260410%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S2 EIF3D EIF2S1 EIF3A EIF3C;EIF3CL EIF2S3;EIF2S3B EIF1 EIF5 EIF1AY;EIF1AX EIF3I EIF3J EIF3G EIF3E EIF3H EIF3B EIF3F CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260410%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling GRK6 TRIM28 CASP3 GNAZ GNB2 GNB3 GNB5 PARP1 ELK1 HSD3B1;HSD3B2 MAP2K2;MAP2K1 MAPK1 BCL2 MAPK3 RHOA GRK3 TFAP2A BRAF MAPK14 PRKAA2 ECE1 FOSL2 ACACA RAF1 NOS3 GNAS-1 CRHR1 CXCL8 FOSL1 NFKBIA SP1 AKT1 GNAI1 MAP3K5 GNAI2 NFKB1 FOS RAP1B TLR4 SULT2A1-4 CRHR2 GNAO1 GNAQ TGFB1 GNB1 IL18 CREB1 NCOA2 CRH CACNA1H PTK2 JUP GSK3B STAR CTNNB1 ARRB1 ARRB2 IL2 HSP90AA1 CYP11A1 NR4A1 PRKCQ KRT16;KRT14 CRHBP JUNB CAMK2A KRT1 PRKCB IVL RAPGEF3 PLCG2 TCF4 PRKCD GNA11 TBX19 GJA1 PRKCA PLCG1 RELA MAPK9 POMC PRKCI JUND ERN1 CYP11B1;CYP11B2 CYP21A2 CASP9 FOSB NR4A2 MAPK8 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260410%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ IKBKG RRAS TRAF6 NFKB1 MAPK1 MAP3K14 MAP2K6 RAF1 CHUK NFKBIA IKBKB MAP3K1 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260410%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function NOS2 SORD PRKD3 BDNF MMP1 TRPA1 TRPV1 MMP25 SCN9A MMP3 C3-1 PRKCG MMP7 SCN10A MMP2 MMP21 SCN8A MMP20 MMP9 PRKCQ MMP24 MMP27 SNAP25 MMP28 MMP12 MMP14 MMP10 MMP13 SLC2A1 MMP11 MMP16 MMP15 AGER MMP17 PRKCZ MMP19 PRKCH PRKCB PRKCE PRKCD TKTL1 PRKCA MMP8 PRKCI MMP23B MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260410%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 MCL1 BCL2 TP53 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260410%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 OXCT1-1 ACAT2 HMGCS1-1 ACAT1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260410%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway SMPD1 UGT8 CERS3 DEGS1 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGCG CERS4 ASAH1 SGPL1 CERS5 CERS6 PLPP3 PLPP2 KDSR PLPP1 CERS1 CERS2 SPTLC1 DEGS2 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260410%WP5360%HOMO SAPIENS KCNQ2 related epilepsies ANK3 P2RY1 AGTR1 ITPR1 KCNQ2 KCNQ3 PLCG2 CHRM1 PRKCA AKAP5 CSNK2A1;CSNK2A3 PRKACA-1 SCN1B CALM1 STX1A BACE1 PPP1R10 PPP3CC BDKRB2 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260410%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling MYC AXIN2 FGFR4 FGFR1 ELK1 FLT1 SALL4 MAP2K2;MAP2K1 PYGO1 FLT3 TTI1 PML BCL9 FLT4 MAPK1 HRAS AKT1S1 MAPK3 WNT1 CDKN1A JUN BRAF IGF1R GRB2 CSNK1A1 KRAS SOS1 RAF1 CHUK NTRK1 INSR FZD6 FGFR3 SOS2 NTRK2 IKBKB NFKBIA TEK PIK3CD AKT1 IKBKG TSC1 NFKB1 RPTOR FOXO1-1 FOS MLST8 KDR TP53 MDM2-2 ULK2 TELO2 EPHA2 RARA IL6 NGFR RHEB IL6R PTK2 JUP GSK3B LRP5 CCND1 EGFR LRP6 AKT3 CTNNB1 FGFR2 PDGFRB KIT NFKBIE AKT2 STAT3 PPARD MTOR PTEN REL PIK3CB RUNX1T1 PIK3CG JAK2 RETN KSR1 PDGFRA LEF1 TSC2 APC GAREM2 MET SRC DEPTOR RELA ZBTB16 SHC1-1 PIK3CA CSF1R MRNA PROCESSING%WIKIPATHWAYS_20260410%WP411%HOMO SAPIENS mRNA processing SUPT5H RBM39 NCBP2-1 DDX20 HNRNPH1 YBX1 DHX9 SRSF9 HNRNPAB HNRNPL FUS HNRNPK PRMT1 U2AF2 SF3A3 DICER1 SF3B4 CELF1 DHX15 U2AF1L5;U2AF1 METTL3 HNRNPR CLP1 PAPOLA TXNL4A PSKH1 PRPF4B CDC40 SRRM1 PRPF4 PRPF6 HNRNPD PRPF3 XRN2 SRSF2 SRSF3 SREK1 SRSF5 SRSF6 SRSF7 SNRPA DHX8 CSTF3 CSTF2 SNU13 DHX38 SRPK2 CPSF4 CPSF1 CPSF3 CLK4 CD2BP2 CLK3 LSM2 NONO CLK1 LSM7 RNPS1 CLASRP HNRNPC SUGP2 TMED10 SUGP1 CELF2 CELF4 SNRNP70 RBM5 RBM17 CPSF2-1 PTBP1 PRPF18 HNRNPH2 DNAJC8 HNRNPA1-1 SFSWAP CLK2 RNMT SPOP SRSF1 CSTF2T NXF1 TRA2B SRSF4-1 NUDT21 HNRNPM HNRNPA2B1 PABPN1-1 RBMX SNRPD2 SNRPD1 SNRPD3 SRP54 SNRPN EFTUD2 SNRPF SNRPB PRPF8 SNRPE-2 PRPF40A PTBP2 DHX16 PRMT2 SF3B1 SNRPA1 PCBP2 SF3B5 SFPQ-1 SF3B2 SF3B3 SNRPG-2 PPM1G SF3A1 SRSF10 SF3A2 SNRNP40 PHF5A SMC1A SRPK1 SNRPB2 RNGTT HNRNPU DDX1 POLR2A NCBP1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260410%WP3963%HOMO SAPIENS Mevalonate pathway PMVK MVD HMGCR ACAT2 HMGCS1-1 FDPS MVK HINT1 PATHWAY%WIKIPATHWAYS_20260410%WP5523%HOMO SAPIENS HINT1 pathway GTF2H4 USF2 CDK7 KARS1 ERCC3 TCF4 SH3RF1 HINT1 RUVBL2 MITF CTNNB1 NFKB1 MAPK9 NFATC2 FOS ERCC2 RUVBL1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH JUN GTF2H1 GTF2H3 MNAT1 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260410%WP5382%HOMO SAPIENS TGFB Smad signaling SPARC SMAD2;SMAD3 WWTR1 SMAD4 POSTN TGFBR2 SERPINE1 TGFBR3 CCN2 YWHAG TGFBR1-1 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260410%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence KLF5 EIF2AK1 IFNG KMO IFNB1-4 NOS1 AHR EIF2AK4 HAAO AFMID TDO2 AADAT IL1R2 FOXO1-1 KYNU IDO2 TLR4 TNF CAT TP53 QPRT CDKN1A IDO1 ACMSD AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260410%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways SNX10 RAB7A TRAF6 NFKB1 TNFRSF11A TNFSF11 PLEKHM1 TCIRG1 CLCN7 IKBKB OSTM1 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260410%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 ACE AGTR2 AGTR1 REN NOS1 PRKG1 SERPING1 IL1A KLK1 MAPK1 F12 BDKRB2 KLKB1 BDKRB1 RHOA ROCK1 IL1B AGT VDR NOS3 CYP24A1 ACE2 NFKB1 KNG1 NPR1 TNF SERPINE1 CPN1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling TRAF5 MCL1 TNFSF10 BMF ELK1 CFLAR MAP2K7 BCL2 MAP2K6 FAS MAP2K3 MMP2 CDKN1A MAP2K4 JUN TRAF2 MAPK14 MAPK12 MAPK13 BAK1 ATF2 BAX BCL3 BCL2L1 MAP3K5 TRAF6 TNFRSF1A FOS CCNE1 BID TP53 IL6 NFE2L2 CCND1 EGFR MAPK11 CCNA2-1 IL2 HSP90AA1 HBEGF CDKN2A IFNG JUNB PDGFRA FGF7 RB1 FASLG BCL2L11 TNF MAPK8 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260410%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 SMARCC2 H3-3A PTCH1 CDK4 EED GLI1 GLI3 GLI2 SMO SMARCD1 SMARCD2 SMARCD3 SUZ12 CDKN2A SMARCC1 ARID1A ACTL6B RBBP4 ACTL6A ARID1B SMARCA4 SMARCE1 SMARCB1 CDK6 RB1 GLI4 DPF1 DPF2 DPF3 EZH2 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260410%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A IL1B NEK7 NLRP3 RAPGEF3 PRKACB-1 PRKAR2A 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC42 APC AMER3 PLEKHB2 MZT2A;MZT2B STMN2 STAT3 FAM168B RAC1 ARHGEF4 GPR148 RHOA CDC27 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias SC5D DHCR7 LBR CYP51A1 DHCR24 NSDHL EBP 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5408%HOMO SAPIENS 15q25 copy number variation AP3M2 BTBD1 C15orf40 FSD2 SYNJ1 WHAMM PDE8A SEC11A NMB HOMER2 TM6SF1 SHANK3 AP3B2 AP3S2;AP3S1 CPEB1 SPCS2 ALPK3 HTT SLC28A1 ZSCAN2 TOP1 AP3D1 DNM3 NMBR RNMT RYR2 SH3GL3 SLC2A1 ITPR1 RAF1 AGAP2 EGF RYR1 GRM1 GRM5 SHANK1 WDR73 SPCS1 RAMAC ZNF592 BNC1 ADAMTSL3;ADAMTSL1 TENT4B SPCS3 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway VAV1 BCR HSPB2 CRK PTK2 PIK3R1 CBL MAPK11 ARAF AKT3 NRAS BCL9 MAPK1 EIF4B AKT2 HRAS BCL2 MAPK3 MAP3K2 BCLAF1 BRAF MAPK14 GRB2 INPP5D RPS6KA1 KRAS SOS1 RAF1 ATF2 SRC PXN AKT1 CRKL MEF2C SHC4 HSPB1 SPAG1 SHC2 SHC3 ABL1 DOK1 SHC1-1 PIK3CA BCAR1 GAB2 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260410%WP2855%HOMO SAPIENS Dopaminergic neurogenesis TGFB1 NEUROG2 LMX1B OTX2 RET NEUROD1 PITX3 EN2 LMX1A GLI1 NKX2-2 GLI2 SHH DDC STAT3 TH WNT1 SLC18A2 GBX2 MSX1 EN1 SLC6A3 FGF8 ALDH1A1 FOXA2 NKX6-1 ASCL1 SOX2 CDKN1C NR4A2 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260410%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide TGFB1 IFNG VIP IL10 CTLA4 IL2 IL4 CD86 FAS CD80 IL5 CD28 IL12A OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260410%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFV1 NDUFA8 NDUFA7 NDUFA6 NDUFA3 ATP6AP2 NDUFC1 NDUFS6 NDUFAB1 NDUFS4 NDUFS3 NDUFS2 ATP6AP1 NDUFS1 NDUFS5-1 NDUFB9 GZMH;GZMB-1 NDUFA11 ATP5MC2 ATP5MC3 ATP5MC1 NDUFA10 NDUFS8 NDUFS7 NDUFA4L2 ATP5MG ATP5ME DMAC2L ATP5PF ATP5PD ATP5F1A ATP5F1B NDUFA9 NDUFA4 NDUFA5 ATP5PB ATP5F1D ATP5PO NDUFB8 NDUFB7 NDUFB10 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260410%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling TGFB1 SMAD2;SMAD3 IL18 IL6 TBX21 IL21R IL4R IL17F IL2RG IL10 TLR5 STAT4 IFNGR1 IL1A IL18RAP IL2 STAT1 IL4 STAT3 IL12A STAT6 JUN IL12RB1 IL12RB2 IFNG IL23A NFATC1 NOD2 FOXP3 HLA-DMA MAF TLR2 NFKB1 RORA GATA3 TLR4 TNF IL13 IL21 IL5 IL22 IL23R RORC EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260410%WP3930%HOMO SAPIENS EDA signaling in hair follicle development DKK1 LTB DKK4 SOSTDC1 PTCH1 EDA EDARADD GLI1 RELB SHH EDAR WNT3 BMP1 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260410%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD2 GOT2-1 ASPA DARS1 PC ASL GPT AGXT ASS1 ABAT GOT1-1 GAD1 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5380%HOMO SAPIENS 5q35 copy number variation MYC FGF19 BARD1 FGFR4 GAB1 EED F12 KDM6B FBXW7 ADAM10 JUN HIP1 GPRIN1 MAPK10 IGF1R GRB2 SOS1 NSD1 GNAI3 GNAI1 GNAI2 NELFB H3-3A PIK3R1 COX6A1 ARL10 COX6B1 COX7B COX4I1 FGF1 COX7C PNPLA2 COX8A NTN1 CXCR4 COX5B COX5A CYP7A1 MAGED1 TPM2 HK3 MAX MAPK8 GRK6 CLTB UIMC1 RGS14 ABRAXAS1 BRCC3 TMED10 TMED2-1 PDLIM7 GRIN2B EIF4E1B SNCA COX6C GRIN1 KIAA1191 CAPN3 RNF44 UNC5A MYO7B HIC2 DRD2 FRS2 DOK3 ABHD5 SLC34A1 PRELID1 PTPRN2 NOP16 HIGD2A MXD3 BRCA1 PRR7 FAF2 DDX41 BABAM1 BABAM2 PTPN2 TMED9 USH1C ARFGAP2 INPP5D CDHR2 FAM193B CDHR5 DBN1 LMAN2 RAB24 ZNF346 SNCB B4GALT7 SRC HIP1R SIMC1 PLCG1 TSPAN17 ANKS4B MAPK9 PTH ABL1 PFN3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260410%WP4630%HOMO SAPIENS Measles virus infection MX1-1 CD3E CD3D BAD CSNK2B CSNK2A1;CSNK2A3 IL2RG CDK4 HSPA8 IL2RA IL2RB IL12B IL12A JUN TP73 HSPA1L HSPA6 MAPK10 CCND3 IKBKB PIK3CD CDK6 IKBKG TLR2 FOS SLAMF1 RACK1 CCNE1 JAK1 IFNAR2 TP53 TYK2 IL6 CDK2 TLR9 IRF9 IFNAR1 PIK3R2 CCNE2 PIK3R1 TLR7 EIF2AK2 OAS3 STAT5A IL2 STAT1 STAT2 STAT3 DDX58 IL1B ADAR IFIH1 MAVS OAS1 FASLG HSPA2 PIK3R3 CASP9 TNFAIP3 CYCS-1 MAPK8 CASP8 CASP3 FADD MAP3K7 NFKBIB TRADD APAF1 IL1A BCL2 FAS RAB9A EIF2AK1 EIF2AK3 TBK1 IRAK1 IKBKE BAK1 IFNB1-4 CHUK MSN IRAK4 EIF2AK4 BAX NFKBIA IRF3 BCL2L1 TRAF3 HSPA1A;HSPA1B TRAF6 NFKB1 IRF7 TAB2 TLR4 MYD88 BID CD28 CLEC4M;CD209-2 CCND1 EIF3H PIK3CB EIF2S1 CDKN1B JAK3 CBLB RELA CCND2 RCHY1 MAPK9 NECTIN4 RAB9B STAT5B NFKB2 PIK3CA CSNK2A2 CD3G BBC3 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome PLK1 STAG2 PTTG1;PTTG2 HDAC8 SMC1B CDK1 PTPA REC8 PDS5B PDS5A PPP2R1A RAD21 PPP2R5C WAPL PPP2CB;PPP2CA SMC3 AURKB SMC1A PPP2R5D NIPBL APC PPP2R1B ESPL1 CDCA5 ESCO1 ESCO2 SGO1 SGO2 MAU2 PPP2R5E STAG3 PPP2R5B PPP2R5A AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260410%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GLYAT ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260410%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SNAP25 ANK2 ANK3 EIF2AK3 EIF2A KCNQ2 L1CAM MAPT SPTAN1 CSNK2B PRICKLE1 ATF4 CSNK2A1;CSNK2A3 ATF6 DNM1L SCN5A PRRT2 SEMA3A BRSK1 CSNK2A2 DDIT3 SPTBN4 SCN2A BRSK2 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260410%WP170%HOMO SAPIENS Nuclear receptors RXRB NR2E1 RXRA RXRG ESRRB RARA NR0B1 NR5A2 PGR NR1D2 ROR1 NR5A1 RARG THRB AR NR1H3 ESR2 NR1I3 NR1I2 NR4A1 ESR1 RARB PPARD NR2F1 PPARA PPARG THRA NR2C2 VDR HNF4A ESRRA NR1H2 NR2F6 RORA NR3C1 NR2F2 NR4A2 RORC CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation ESRRB RIMS2 LMX1B PPFIA1 BSN AP2A1 RBFOX3 TPH1 FBXO15 TBR1 LIN7A FUT4 EVX1 ROBO1 DLG3 CD24 MSX2 NES PCLO ERC1 MAP2 HTR1A DPPA2 ERAS MBP GLRA1 GLRA2 GLRA3 GLRB NANOG;NANOGP8 RIMBP2 FEV CNP DPPA3 ZFP42 SNAP25 MSX1 HES3 BMP4 SLC6A4 SNAI1 SLC6A2 SLC6A3 KRT15 GAD1 HOMER3 GPHN GLS GABBR2 AP2A2 KCNJ6 KLF4 CASK NGFR SYP ACHE TUBB3;TUBB6 FABP7 TH CSPG4 CD34 UNC13A CACNG2 FGF4 NOTCH1 SNAI2 DLL1 LEF1 ALDH1L1 HES1 HNF4A PAX6 HES5 CDH2 TPM1 SLC6A5 HOMER1 DLG4 SHANK3 ITGB1 GLUL CLDN11 POU5F1;POU5F1B SLC1A2 SLC1A3 ITGA6 GRIN2B GFAP SLC6A9 CDH1 GATA6 SOX10 NLGN1 HTR5A ADRA2C SLC18A3 ADRA2B FOXD3 ADRA2A GATA4 OLIG2 SOX9 SLC17A6 SLC17A7 MOG CHAT LHX1 TNC HOMER2 GRIN1 DCX NODAL DLG2 SLC6A1 GABBR1 PAX3 PECAM1 TBXT GAD2 DLG1 MIXL1 FOXA2 SOX17 SHANK1 TWIST2 NEFL AQP4 NEFM SOX2 NR4A2 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260410%WP5606%HOMO SAPIENS Beta globin gene expression regulation BCL11A LMO2 NR2C2 HDAC2 HDAC1 HBD;HBB GATA1 HBG2;HBG1 LDB1 TAL1 PPARGC1A CHD3 KDM1A KLF1 MTA2 NR2C1 GATAD2B ZFPM1 MYB ZBTB7A DNMT1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling TGFB3 NOS2 MCL1 HK1 BIRC5 PGK1 BCL2A1 PMAIP1 PDHA1 EPO BNIP3L ARNT IGFBP2 TGFA HIF1AN LDHA PKM SLC16A1 IGFBP3 SLC2A1 EGLN1 IGFBP1 BNIP3 BAK1 ANGPT2 BAX ANGPT1 HIF1A BCL2L1 EDN1 BID SERPINE1 VEGFA PFKL TP53 PTGS2-2 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP3869%HOMO SAPIENS Cannabinoid receptor signaling PRKAR1B PRKAR1A FAAH ADORA2A AHR PRKAR2B MAPK11 MAPK1 DAGLA MAPK3 NAPEPLD DAGLB MAPK14 CYP1A1 MAPK12 MAPK10 MAPK13 ADCY1 ADCY7 CNR1 CNR2 PRKACB-1 PRKACA-1 MAPK9 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAPK8 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260410%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response VCAM1 IL6 CXCL8 ICAM1 ITGB1 C5 C6 IL1A C7 KNG1 ITGB2 TNF SELP C3-1 ITGA4 ITGAL SELPLG LUNG FIBROSIS%WIKIPATHWAYS_20260410%WP3624%HOMO SAPIENS Lung fibrosis CYSLTR2 CEBPB SERPINA1 ELMOD2 DSP CMA1 CCR3 CCR2 BMP7 MMP2 IL12B MMP9 FAM13A GREM1 CCL11 RTEL1 PARN DPP9 STN1 MUC5B CCL5 SKIL MECP2 SMAD7 MT2A EGF CXCL8 EDN1 IL13 CCN2 TIMP1 PTX3 CCL13;CCL2 PDGFB HMOX1 TGFB1 TERT IL6 IGF1 NFE2L2 ATP11A PDGFA CSF3 CSF2 CXCL2;CXCL3;CXCL1-1 IL4 CCL4L2;CCL4L1;CCL4 TGFA FGF1 FGF2 IL1B HGF FGF7 CALCA CCL3L1;CCL3L3;CCL3;CCL18 PLAU TNF IL5 SFTPC SPP1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260410%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2;SMAD3 PMEPA1 LDLRAD4 TGFBR2 NEDD4 ATG16L1 TGFBR1-1 ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP1541%HOMO SAPIENS Energy metabolism SIRT3 RXRA UCP3 PPP3CA CREB1 TFAM-1 PPP3R1 GSK3B PRKAG1 HDAC1 PRKAG2 GABPA PRKAG3 PPARGC1A PRKAA1 EP300 MYBBP1A PPARGC1B PPP3CB PPP3CC PPARD PPARA PPARG MEF2D MAPK14 MEF2B;BORCS8-MEF2B PRKAA2 MED1 ATF2 ESRRA CAMK2G TFB2M MEF2A TFB1M NCOA1 MEF2C FOXO1-1 PPRC1 CAMK4 UCP2 SIRT1 PRKAB2 FOXO3 PRKAB1 PRMT1 NRF1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260410%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX12 DPEP1 PTGIS PTGDS LTC4S LTA4H PTGES2 PTGES PLA2G5 PLA2G6 PTGS1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B GGT1 ALOX15B PTGS2-2 PLA2G4A ALOX5AP CBR1-1 ALOX15 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260410%WP51%HOMO SAPIENS Regulation of actin cytoskeleton FGF14 FGF19 FGF13 FGFR4 FGF12 FGF11 FGFR1 FGF10 NRAS MAP2K2;MAP2K1 RRAS MAPK1 ENAH MAPK4 MAPK3 BRAF KRAS FGF18 SOS1 RAF1 MYH10 SSH2 FGFR3 SSH3 SOS2 EGF SSH1 MOS VIL1 DIAPH3 PIP5KL1 PIK3CD FGD1 WASF2 RAC3 ABI2 FGF16 GNA13 NCKAP1 GNA12 RAC1 ARHGEF1 PDGFB VAV1 PIK3C3 CRK FN1 PIK3R4 PIK3R2 ARPC5 PIK3R1 EGFR CFL2 FGF21 BDKRB2 BDKRB1 FGF1 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 GIT1 FGF8 PIK3R3 ACTG1 PIK3R5 MYL1 ARHGEF6 PAK1 CD14 MYL3 BAIAP2 ARHGEF7 PAK2 LIMK1 ACTB-1 ITGA1 RHOA EZR ROCK2 ROCK1 WAS WASF1-1 CDC42 RRAS2 MRAS CHRM3 CHRM1 MSN CHRM4 CHRM5 ACTN1 DIAPH1 CSK RDX ARHGEF4 FGF9 BCAR1 RASSF7 ARHGAP35 PTK2 PDGFA VCL FGFR2 PDGFRB F2 PAK3 PAK5 PAK4 PIK3C2G PIK3CB PPP1R12A PIK3C2A PIK3CG PIK3C2B GSN CYFIP2 BUB1B-PAK6;PAK6 SLC9A1 DOCK1 PDGFRA PIP5K1A APC F2R PIP4K2A CFL1 PIP4K2B PIP5K1B PXN PIP5K1C MYLK PIP4K2C MAPK6 CHRM2 FGF20 APC2 FGF23 IQGAP1 FGF22 PFN1 PIK3CA FGF17 SLC25A46 PATHWAY%WIKIPATHWAYS_20260410%WP5521%HOMO SAPIENS SLC25A46 pathway EMC8 MICOS13 SLC25A46 OPA1 MFN1 MFN2 DNM1L APOOL MMGT1 IMMT MICOS10 EMC10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 EMC4 EMC6 EMC7 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260410%WP5124%HOMO SAPIENS Alzheimer 39 s disease PPP3CA BAD HSD17B10 ARAF RB1CC1 NRAS MAP2K2;MAP2K1 MAPK1 MAP2K7 HRAS MAPK3 NRBF2 ATG2B IDE ADAM10 TUBA1C MME PSMA8 BRAF TUBB4B TUBB1 CAPN1 TUBA4A MAPK10 PLCB3 RTN3 PSMD14 CACNA1D CACNA1C KRAS KLC1 RAF1 KLC4 KLC3 KLC2 TUBA3E;TUBA3C-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 IRS1 ATP2A3 PIK3CD TUBB2B;TUBB2A IRS2 SLC25A6 TUBAL3 BECN2 ADRM1 SLC25A31 CYBB GNAQ PIK3C3 PIK3R2 PSENEN PIK3R1 LPL PSEN1 APH1A NCSTN APH1B BACE1 ATG101 MTOR WIPI2 TNF PIK3R3 NOX4 GRIN2A ERN1 CALM3;CALM1 CALM2 RYR3 CASP9 CYCS-1 CASP7 MAPK8 CASP8 CASP3 FADD ATF4 APAF1 APBB1 IL1A INS;INS-IGF2 FAS SEM1 APP EIF2AK3 GRIN2C AGER GRIN2B GRIN2D INSR ATF6 SNCA PPID NFKB1 TNFRSF1A BID VDAC2-1 WNT4 VDAC3 GRIN1 GSK3B CAPN2 AKT3 CTNNB1 ATP2A1 AKT2 ADAM17 SLC25A5 CACNA1F PIK3CB CACNA1S EIF2S1 WNT3A WNT5A ITPR1 AXIN1 MAPT DKK4 APC WNT2B FZD10 CDK5R1 FRAT2 CALM1 APC2 WNT5B PLCB4 PIK3CA CSNK2A2 PLCB1 AXIN2 WNT16 PLCB2 DKK1 DKK2 SFRP4 CSNK2B GAPDH-1 CSNK2A1;CSNK2A3 WNT6 WNT11 CALML6 DVL1 CALML3 DVL2 CALML4 DVL3 WNT1 WNT2 WNT3 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 CSNK1A1 WNT7B FZD7 CDK5 FZD6 FZD9 FZD8 WNT7A IKBKB AKT1 GPR83 MAP3K5 TPTEP2-CSNK1E;CSNK1E SLC25A4 WIPI1 CHRNA7;CHRFAM7A ATG13 PTGS2-2 ATG2A DDIT3 NOS2 IL6 NOX1 NAE1 AMBRA1 ATG14 PIK3R4 LRP5 LRP6 EIF2AK2 TUBB3;TUBB6 CSF1 IL1B PSMD8 ITPR3 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 PSMC2-1 PPIF PSMA5 MCU PSMA6 PSMA3 PSMA4 PSMA1 PSMD12 RTN4 PPP3CB PPP3CC PSMD13 PSMA7 PSMB6 PSMB7 TRAF2 PSMB4 PSMB5 PSMB2 BECN1 PSMB3 PSMB1 PSMA2-1 CHUK PSMC5 PSMC6 PSMC3 PSMC4 ATP2A2 PSMC1 ITPR2 TUBA1A LRP1 APOE ULK2 ULK1 PPP3R1 NOS1 VDAC1 PSEN2 KIF5C IRS4 KIF5B KIF5A XBP1 RELA MAPK9 IL26 SIGNALING%WIKIPATHWAYS_20260410%WP5347%HOMO SAPIENS IL26 signaling SMAD2;SMAD3 CASP3 MPO IL6 IL20RA IL10RB MMP1 SOCS3 CTSK IL10 IL17A CSF2 MAPK1 STAT1 STAT3 MAPK3 MMP9 JUN ATP6V0D2 MAPK14 JAK2 IL1B DCSTAMP DEFB4A;DEFB4B CXCL8 NFATC1 BAX ICAM1 NFKBIA AKT1 RELA MAPK9 IL26 TNF EPHA3 TNFSF11 JAK1 ACTA2 CCL20 PIK3CA RORC IL33 DDIT3 MAPK8 TYK2 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260410%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer CUL1 TRAF1 VIM BIRC5 PAK2 HDAC1 RIPK2 MAPK1 HELLS VAV3 CDKN1A TNFRSF21 YBX3 APP SMAD7 AKT1 BCL3 NFKB1 HSPD1 APOE SERBP1-1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A IER3 CUL5 CARD14 BEX3 NET1 ETS1 PTK2 PKN1 SOCS3 THBS1 SQSTM1 RNF7 CTNNA1 IL7R GCLC RPS6KB1 HSPA5 CDKN1B NRG1 AXIN1 ANXA5 F2R PTK2B HSPB1 TNF ABL1 JUND ERN1 ERBB3 CASP7 NQO1 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260410%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GATM F10 F7 GLS2 ARG1 ASL GPT NAGS ASS1 OTC GAMT GOT1-1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260410%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria MBD3 E2F1 RBBP4 CBX1 MTA1 MTA3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CBX5 LEF1 H3-3A HDAC2 HDAC1 INPP5K RBBP7 CHD4 SREBF1 RB1 CHD3 KDM1A SUV39H1 CBX3-1 MTA2 MBD2 TP53 DNA REPLICATION%WIKIPATHWAYS_20260410%WP466%HOMO SAPIENS DNA replication CDK2 ORC5 ORC4 ORC6 ORC3 ORC2 MCM2 POLD3 POLD4 DBF4 PCNA POLD1 CDC6 MCM7 POLD2 CDC45 POLE MCM10 RFC5 RPA3 RFC3 RPA1 RFC4 PRIM2 RPA2 MCM3 GMNN RFC1 MCM4 RFC2 POLA2 MCM5 MCM6 UBB;UBC POLE2 ORC1 CDT1 CDC7 POLA1 PRIM1 UBA52 MAPK SIGNALING%WIKIPATHWAYS_20260410%WP382%HOMO SAPIENS MAPK signaling MYC FGF14 PPP3CA FGF19 FGF13 PTPRR FGFR4 FGF12 FGF11 FGFR1 FGF10 CDC25B ARAF ELK1 RASA1 NRAS MAP2K2;MAP2K1 RRAS HSPA8 MAPK1 MAP2K7 HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP3K1 PTPN5 BRAF MAPK14 MAPK12 MAPK10 GRB2 CACNA1D CACNA1C MAPK7 KRAS SOS1 MKNK1 RAF1 MKNK2 LAMTOR3 SOS2 EGF NFATC1 MAP3K12 CRKL RPS6KA4 RPS6KA5 RAP1B GNA12 RAC1 LRRK2 CRK EGFR RAP1A FGF21 RASA2 MAPK8IP2 NR4A1 NF1 DUSP10 HSPB1 FASLG TNF HSPA2 RASGRP2 CACNB3 CACNA1B PAK1 TAOK2 CACNA1A CACNA1E MAPK8 CD14 CASP3 PAK2 MAP3K7 ATF4 DAXX MAPKAPK5 IL1A MAPKAPK3 IL1R2 MAPKAPK2 FAS SMIM40 PLA2G4A CDC42 RRAS2 MRAS PRKACB-1 HSPA1A;HSPA1B NFKB1 TNFRSF1A FGF9 ECSIT TGFB2 FLNA TGFB1 FLNB TGFB3 IL1R1 FLNC MAP3K14 CACNA1H PDGFA MAPK11 AKT3 FGFR2 PDGFRB ARRB1 ARRB2 AKT2 CACNB1 DUSP4 CACNB2 PRKCG DUSP2 RASGRF1 CACNA1F TGFBR1-1 CACNG1 CACNA1S MAPT TGFBR2 PLA2G4F PLA2G4D PLA2G4E CACNA2D1 NFKB2 PPP5C NLK JMJD7-PLA2G4B;PLA2G4B TAOK1 HSPA1L HSPA6 MAPK13 FGF18 FGFR3 ATF2 GADD45A IKBKB AKT1 PRKACA-1 IKBKG RAC3 MAP3K5 FGF16 FOS TP53 DDIT3 PDGFB DUSP6 CACNA2D3 CACNA2D2 CACNA2D4 MAPK8IP3 DUSP8 DUSP9 NFATC3 DUSP7 RAPGEF2 RASGRP1 TAOK3 RASGRP4 CACNB4 RASGRP3 CACNA1G MAP3K20 RASGRF2 DUSP16 PPM1A RELB PPM1B CACNG6 CACNG7 CACNG3 NTF4 CACNG4 CACNG5 NTF3 PTPN7 FGF1 CACNG8 FGF2 CACNG2 IL1B FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 MAP3K6 MAP3K4 MAX MAP3K8 MAP2K5 BDNF MAP3K11 PPP3CB PPP3CC TRAF2 NGF CHUK NTRK1 NTRK2 RPS6KA3 TRAF6 TAB2 TAB1 CACNA1I MAPK8IP1 DUSP1 PPP3R1 MAP4K1 MAP4K2 MAP4K3 MAP4K4 STK4 MAP3K13 ELK4 PRKCD PRKCA STMN1 DUSP3 RELA MEF2C STK3 MAPK9 FGF20 JUND SRF FGF23 FGF22 FGF17 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260410%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis ACSL4 FADS2 FADS1 ACSL1 ELOVL5 ELOVL2 ACSL3 ACOX1 ACOT2;ACOT1 ACOX3 PLA2G5 PLA2G6 JMJD7-PLA2G4B;PLA2G4B PLA2G4A LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260410%WP5314%HOMO SAPIENS Lactate shuttle in glial cells SLC4A4 SLC16A1 CA2 CA4 SLC2A1 SLC16A7 HK1 LDHB SLC1A2 NUDT14 SLC16A3 LDHA TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260410%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2;SMAD3 GLI3 SHH FOXG1 NKX2-1 NODAL TGIF1-1 FGF8 TGIF2 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260410%WP363%HOMO SAPIENS Wnt signaling NetPath PI4K2A GCKR MAP3K7 GSK3B ROR1 ROR2 LRP5 LRP6 CCND1 CTBP1 CTNNB1 NLK BCL9 ARRB2 MAPK1 CSNK1D DVL1 DVL2 PRKCG DVL3 MTOR SOX1 PPARG RHOA TCF7L2 CSNK1G1 CSNK1A1 AXIN1 LEF1 PRKCB TSC2 TCF4 PRKCA APC GSK3A PIP5K1B AKT1 CDK6 TPTEP2-CSNK1E;CSNK1E MAPK9 TSC1 NFATC2 RAC1 RYK-1 MAPK8 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260410%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2-1 SLC25A11 MDH1 SLC1A3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260410%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCD3 ITPR3 PLCB2 PLCD1 PLCB3 PLCG2 PLCZ1 GNA11 PLCH1 PLCE1 PLCG1 PKD1 FFAR1 PLCL1 PLCB1 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260410%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 AKT2 INSR MTOR RPS6KB1 RPS6 TBC1D4 IRS1 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism HSD17B8 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD17B10 COMT CYP1B1 HSD17B1 HSD17B2 HSD17B3 HSD17B4 HSD17B7 CYP2C9;CYP2C19 CYP19A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A2 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260410%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases LGMN APP SRPK2 BDNF CEBPB MAPT NTRK2 AKT3 SNCA AKT1 TARDBP STAT1 SET-1 AKT2 MAOB BACE1 PPP2CB;PPP2CA ID SIGNALING%WIKIPATHWAYS_20260410%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 RBL1 CDK2 ELK4 RBL2 ELK1 SREBF1 RB1 MYOD1 ID2-1 PAX8 CCNE1 ID3 ID1 PAX2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5049%HOMO SAPIENS Glycolysis in senescence PKM RB1 PRKAA1 G6PD HK1 ALDOC ENO1 GAPDH-1 TP53 PGK1 LDHA TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260410%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EREG RHEB AKT3 NRAS AKT2 HRAS STAT3 MTOR PTEN TGFA JAK2 PDK1 JAK3 GRB2 KRAS SOS1 TSC2 RAF1 EGF SOS2 AKT1 TSC1 RPTOR JAK1 BTC TYK2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260410%WP4262%HOMO SAPIENS Breast cancer pathway MYC AXIN2 WNT16 FGF19 E2F1 PGR SFRP4 FGFR1 CSNK2B FGF10 CSNK2A1;CSNK2A3 ARAF CDK4 E2F2 E2F3 NRAS MAP2K2;MAP2K1 MAPK1 RAD51 WNT6 WNT11 HRAS DVL1 DVL2 MAPK3 DVL3 WNT1 WNT2 CDKN1A WNT3 FZD1 JUN SKP1 WNT10B BRAF TCF7L2 WNT10A FZD3 TCF7L1 IGF1R FZD2 FZD5 GRB2 CSNK1A1 KRAS FGF18 SOS1 WNT7B RAF1 FZD7 GADD45B FZD6 GADD45A FZD9 SOS2 EGF FZD8 GADD45G WNT7A RPS6KB2 AKT1 PIK3CD BRCA2 CDK6 FGF16 NCOA1 FOS NCOA3 TP53 PIK3R2 PIK3R1 LRP5 EGFR LRP6 ESR2 FGF21 ESR1 MTOR POLK RPS6KB1 FGF1 FGF2 CETN3 FGF3 FGF4 NOTCH1 DLL1 FGF5 LEF1 DLL3 DLL4 FGF6 HES1 FGF7 FGF8 HES5 RB1 SHC4 SHC2 SHC3 PIK3R3 PARP1 FLT4 ATR BAK1 BAX SP1 FGF9 WNT4 JAG2 IGF1 GSK3B TCF7 HEY1 HEY2 CCND1 AKT3 CTNNB1 KIT AKT2 DDB2 RAD50 MRE11 ATM PTEN NBN BRCA1 ERBB2 WNT3A WNT5A HEYL AXIN1 APC WNT2B NOTCH2 FZD10 NOTCH3 FRAT2 NOTCH4 FGF20 TNFSF11 APC2 WNT5B FGF23 FGF22 NFKB2 SHC1-1 PIK3CA CSNK2A2 FGF17 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260410%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer BRAF MYC KSR1 KRAS SOS1 RAF1 SOS2 GAREM2 ELK1 MAP2K2;MAP2K1 FOS MAPK3 SHC1-1 ALK JUN FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism HADHB-1 SOD2 ACADM ACLY NOS3 MTTP ESRRA PPARGC1B SLC2A4 AKT2 ESR1 PPARA STK11 APOB INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260410%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MYC TAB3 MAP3K8 IL1R1 TOLLIP MAP3K14 MAP3K7 MAPK11 NFKBIB ELK1 MAP2K2;MAP2K1 IL1A EIF4E MAPK1 MBP MAP2K7 MAPKAPK2 MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP3K3 MAP3K1 MAPK14 MAPK10 SAFB IRAK1 MKNK1 MKNK2 CHUK ATF2 IRAK4 IKBKB NFKBIA TANK RELA TRAF6 MAPK9 NFKB1 IRF7 TAB2 RPS6KA5 FOS TAB1 MYD88 IL1RAP IRAK2 MAPK8 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260410%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF3 DDX58 IRF7 TNFRSF11A MR1 IFIH1 MAVS TLR8 TLR7 TLR3 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260410%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence SIRT3 MDH2 SLC2A1 IL6 IL1B G6PD NMNAT2 ELAVL1 PARP1 GOT1-1 GOT2-1 PRKAA1 RELA SLC2A4 SIRT1 MDH1 NAMPT TP53 CCL27 SIRT5 SIRT2 G13 SIGNALING%WIKIPATHWAYS_20260410%WP524%HOMO SAPIENS G13 signaling ARHGDIB PIK3R2 PKN1 CFL2 IQGAP2 WASL LIMK1 CIT PAK3 CYFIP1 RPS6KB1 RHOA PIK3CB ROCK2 ROCK1 MAPK10 WAS RTKN CDC42 RHPN2 MYBPH SH3RF1 PIP4K2A ARHGDIG CFL1 DIAPH1 PIK3CD PPP1CB GNA13 MAP3K4 CALM1 RAC1 ARHGEF1 IQGAP1 PIK3CA PFN1 MYL1 TNK2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260410%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis MESP2 EPHA4 RIPPLY2 TBX6 WNT3A NOTCH1 DLL1 HES1 LFNG FGF8 HES7 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome KAT2B MTMR10 CCL5 KLF13 OTUD7A CREBBP TRPM1 FANCD2 FYN GPR75 FAN1 CHRNA7;CHRFAM7A SERPINH1 GRM6 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260410%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways PRKAR1B PRKAR1A PLCD1 YWHAB ATF3 PRKAR2B PRKAR2A IGFBP5 RXFP1 IGFBP2 JUN YWHAE RYR2 LPAR1 PLCB3 ATF2 GNAS-1 CRHR1 YWHAH RAMP1 ADCY3 ATP2A3 ADCY2 CNN1 GABPB1 PRKACA-1 YWHAZ FOS GNG2 PDE4D-1 GNAQ GNB1 GUCY1A1 CREB1 IL6 PDE4B DGKZ IGFBP3 CAMK2B IGFBP1 IL1B CAMK2D ACTC1;ACTG2 CAMK2A SFN YWHAG ETS2 CRCP RXFP2 CAMK2G SLC8A1 IGFBP4 RGS4 CNN2 RGS5 ATF5 CALD1 RGS3 ADCY9 IGFBP6 GPR182 RGS1 RAMP2 RAMP3 CORIN GUCA2B GUCA2A RGS6 MYL4 ACTG1 RGS7 ACTA2 CALM3;CALM1 CACNB3 CALM2 RYR3 CREB3 GRK5 MAFF GRK4 MYL2 GRK6 RGS2 ITPR3 PKIB GNG13 PKIA RLN2;RLN1 GNB2 PKIG GNB4 ATF4 GNB3 GNB5 RGS18 RGS17 RGS19 RGS14 RGS16 ACTA1 GNGT1 RGS20 ACTB-1 RGS11 ADCY4 PRKCZ ADCY1 ADCY8 NOS3 ACKR3-2 ADCY7 ADCY6 ADCY5 PRKACB-1 ATP2A2 GNG5 SP1 GNG4 ATF6B ITPR2 GNG8 NFKB1 YWHAQ OXTR OXT-1 MYLK2 CRH NOS1 GABPA GSTO1 ARRB1 ARRB2 PRKCG ADM PRKCQ PRKD1 RGS9 ITPR1 PRKCH PRKCB PRKCE PLCG2 PRKCD GJA1 PRKCA RYR1 RGS10 PLCG1 CALCA CALM1 ATF1 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260410%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL4 FADS2 FADS1 ACSL1 ELOVL5 ELOVL2 ACSL3 ACOT2;ACOT1 ELOVL1 SCD5 SCD ELOVL6 FASN ELOVL3 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260410%WP2889%HOMO SAPIENS Oxytocin signaling PLCD1 CD38 OXTR GNAQ COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2881%HOMO SAPIENS Estrogen receptor pathway GPAM CYP1A1 PDK4 NR0B2 ACOX1 SP1 CYP1B1 PCK1 STAT3 ESR1 PPARA JUN CYP1A2 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260410%WP5461%HOMO SAPIENS Primary ovarian insufficiency ALOX12 CAV1 BMPR2 EIF2B1 LAMC1 EIF2B4 SALL4 SLX4 RAD51 FMR1 ZAR1 CLPP GNAS-1 BMPR1B FANCM FANCL BRCA2 DCAF17 PMM2 MLH1 WRN XRCC4 KHDRBS1 POLR3H LIG4 ESR2 ATG7 PPM1B ESR1 CYP19A1 GALT CENPE EIF2B5 ZP3;POMZP3 PRDM1 PGRMC1 PRORP RCBTB1 MEIOSIN POF1B MEIOB SIL1 TP63 SOHLH2;CCDC169-SOHLH2 HFM1 NANOS3 EXO1 PREPL LGR4 NOBOX LMNA AARS2 PSMC3IP ATG9A AIRE LARS2 SYCP2L HMMR WDR62 SYCE1 ANTXR1-1 SOHLH1 KASH5 PCCA SWI5 COX10 HELQ PCCB HARS2 DIAPH2 H1-8 HROB LHX8 MCMDC2 ELAVL2 POLG C1orf146 FANCI MRPS22 FIGLA TWNK FANCA SPIDR DMC1 RFWD3-2 C14orf39 HAX1 SHOC1 CCDC185 MGME1 MND1 XPNPEP2 ERAL1 SPATA33 NUP107 HSD17B1 EIF4ENIF1 HSD17B4 AMHR2 CYP17A1 SOX8 BNC1 AMH CPEB1 FOXL2 NR5A1 WT1 STAR NUP43 AR POLR2C EIF2B2 BMP15-1 ERCC6 BMPR1A MCM8 MCM9 BMP6 GDF9 FSHR ATM NBN TGFBR3 MSH4 MSH5 NOTCH2 STRA8 FANCC XRCC2 MST1R DAZL SGO2 STAG3 BLM EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP581%HOMO SAPIENS EPO receptor signaling SOCS1 RASA1 MAP2K2;MAP2K1 MAPK1 EPO STAT5A STAT1 STAT3 MAPK3 CISH PTPRC PIK3CG JAK2 PDK1 PTPRU GRB2 SOS1 RAF1 IRS1 SRC AKT1 EPOR IRS2 STAT5B SHC1-1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260410%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy LMNA PKP2 DAG1 ITGB1 ITGB4 DSP ACTB-1 ITGAV ITGA4 DSC2 ITGA3 ITGA2 ITGA1 RYR2 ITGA6 LAMA2 TCF7L2 TCF7L1 CACNA1D CACNA1C DSG2 ATP2A2 ACTN1 CACNA2D3 CACNA2D2 CACNA2D4 JUP TCF7 CTNNB1 CACNB4 SGCA ITGA10 ITGB3 ITGA2B CACNB1 CACNG6 CTNNA1 ITGA11 EMD CACNB2 CACNG7 CTNNA3 ITGB5 CTNNA2 CACNG3 CACNG4 CACNG5 ITGB8 ITGB7 CACNA1F ITGB6 CACNG1 CACNG8 CACNA1S ITGA8 SGCD ITGA7 CACNG2 SGCB ITGA5 SGCG ITGA9 LEF1 DMD GJA1 SLC8A1 ACTN3 CDH2 ACTN2 ACTN4 ACTG1 CACNA2D1 CACNB3 DES IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer TGFB1 TGFB3 IL6 CXCL12 IL17F IL10 IL17A CSF2 CXCL2;CXCL3;CXCL1-1 IL2 IL4 LGALS3 IL12B MMP9 IL12A VEGFB IFNG IL23A VEGFC VEGFD IL1B IL25 CCL5 CXCL8 LGALS1 REG4 LGALS9C;LGALS9;LGALS9B TNF CXCL5;CXCL6 IL13 IL17D CCL20 VEGFA IL5 CCL28 IL17C IL17B CCL13;CCL2 TGFB2 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260410%WP5172%HOMO SAPIENS Iron metabolism disorders HFE FTH1 BCS1L SLC11A2 UQCRFS1 CYBRD1 HEPH TFR2 TFRC HAMP FTL-1 TF CP HJV STEAP3 SLC40A1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260410%WP4537%HOMO SAPIENS Hippo YAP signaling SAV1 STK38L WWTR1 YAP1-1 CXCL10 NF2 MAP4K1 MAP4K2 MINK1 TEAD1 MST1 TEAD2 NDRG1 RASSF1 TEAD3 TEAD4 STK3 LATS1 LATS2 TNIK MAP4K3 MAP4K4 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260410%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis SNAP25 UNC13A RPH3A STXBP5 STXBP6 RIMS1 GDI1 SYP NAPA NSF RAB3A VAMP2 CPLX1 STXBP1 SYT1 CACNA1B CACNA1A GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA1 HEXB B3GALT4 HEXA ST8SIA5 ST3GAL1 ST8SIA6 ST3GAL2 ST3GAL5 NEU3 NEU4 B4GALNT1 ST3GAL4 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260410%WP3878%HOMO SAPIENS ATM signaling in development and disease HDAC4 CHEK2 TRIM28 G6PD CDK2 PPP5C CDC25A DCLRE1C MAPK11 RNF8 NHEJ1 PPM1D BUB1 RBBP8 MDC1 TP53BP1 RAD50 MTOR MRE11 CHEK1 ATM NBN PPP2CB;PPP2CA AURKB KAT5 MAPK14 SMC1A MAPK12 RNF168-1 ATR MAPK13 TSC2 CDK5 ATF2 RNF20 ATMIN-1 RNF40 CEP63 RIF1 IKBKG PRKDC NFKB1 HSPB1 HMGN1 LMNB2 TP53 STK11 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades SERPINA1 CPB2 SERPINC1 TFPI C6 PLAT C7 C9 C5AR1 F12 C3AR1 SERPINF2 MASP2 F5 C3-1 FGB F8 KLKB1 F7 PLG C1QB F13B SERPINE1 LMAN1 CR2 C2 C1QC CD55 CLU SERPING1 MASP1 CFB CFI F2 CFH-3 C8G CFD BDKRB1 SERPINA5 VWF SERPIND1 C1S C1R PLAUR F3 CR1L;CR1 F2R PROC F9 F10 PROS1 APOA2 KNG1 PLAU LOC110384692;C4A;C4B_2;C4B THBD CLTC CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260410%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling TGFB1 MAPK14 GREM1 SMAD2;SMAD3 SMAD4 LOXL4 LOXL2 TGFBR2 BMPR2 LOXL1 MAPK9 LOX BMPR1A BMP1 TGFBR1-1 MAPK8 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260410%WP1604%HOMO SAPIENS Codeine and morphine metabolism SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UGT1A1;UGT1A6 ABCC3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 ABCC2 ABCB1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260410%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COA3 COX10 COX11 COX6A1 COX6B1 COX7A2 COX7B COX4I1 COX7C SURF1 COX8A COX15 COX5B COX5A NDUFA4 COX19 TACO1 COX18 COX6C HIGD1A PET117 COX14 CMC1 TMEM177 COX17 PNKD SMIM20 COX20 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260410%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways WNT16 FGF14 FGF19 FGF13 FGFR4 FGF12 FGF11 FGFR1 FGF10 GAB1 BMPR2 ARAF ELK1 MAP2K2;MAP2K1 ERAS MAPK1 WNT6 WNT11 HRAS MAPK4 DVL1 MAP2K6 DVL2 DVL3 MAP2K3 WNT1 WNT2 WNT3 FZD1 JUN WNT10B BRAF WNT10A MAPK12 FZD3 FZD2 BMP4 FZD5 GRB2 SELENOP MAPK7 FGF18 SOS1 WNT7B RAF1 FZD7 FZD6 FGFR3 FZD9 BMPR1B EGF FZD8 WNT7A AKT1 PIK3CD FGF16 FOS JAK1 MDM2-2 PDGFB SMAD6 PIK3R2 LRP5 EGFR LRP6 FGF21 STAT3 PTPN11 MTOR FGF1 FGF2 FGF3 ACVR1 FGF4 FGF5 FGF6 FGF7 FGF8 ACVR2B MAP2K5 SMAD1 SMAD9 SMAD5 LIF SMAD7 FGF9 NOG WNT4 FZD4 GSK3B PDGFA AKT3 CTNNB1 FGFR2 PDGFRB WNT9B BMPR1A AKT2 PTEN SMAD4 WNT3A WNT5A AXIN1 PDGFRA APC LIFR IL6ST WNT2B HNF1A MAPK6 FGF20 WNT5B FGF23 ACTR2 FGF22 FGF17 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260410%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HIPK2 CDKN1B HMBOX1 HIPK1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260410%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ACSS2 ALDH2 CS ALDH3A2 ALDH9A1 ACO2 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5400%HOMO SAPIENS 6q16 copy number variation AGRP BDNF MC4R GHRL GHSR INSR NTRK2 POMC ARNT INS;INS-IGF2 LEPR NPY LEP SIM1 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5407%HOMO SAPIENS 15q11q13 copy number variation KAT2B GJC2 FANCD2 HDAC1 TJP3 CXADR SIN3A FANCI OCLN-1 APP CCL5 TJP2 FAN1 CHRNA7;CHRFAM7A SPEF1 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 EID3 GJD3 NECAB3 LYPD6 UBN1 GCOM1;MYZAP TRPM3 CANX RIC3 CREBBP SLF1 SLF2 FAM189A1 CGN DNMBP ANKRD2 APBA2 STX1A SERPINH1 CDC42BPB MTMR10 KLF13 OTUD7A GJA1 TRPM1 MITF RELA TJP1 CALM1 STXBP1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260410%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS PDGFB PLP1 MOG IGF1 OMG CNTF MAG NKX2-2 SOX6 GLI2 MBP SOX5 CXCL2;CXCL3;CXCL1-1 SHH NKX2-6 CNP FGF2 MYT1 LIF IL1B BMP4 BMP2 SOX10 TNF ASCL1 OLIG1 SOX8 OLIG2 SOX9 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260410%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 RGS16 CXCL12 PRL MYB KLF2 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260410%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy FGFR4 CEBPB FGFR1 LAMTOR1 MAPK1 MAPK3 JUN NGF MMP13 EPAS1 FOSL2 NTRK1 FGFR3 FOSL1 AKT1 NFKB1 FOS KDR CCN2 SOX9 AKT3 FGFR2 COL10A1 GANC CNMD P4HTM DDR2 RELB AKT2 ARNT STAT3 RUNX2 JAK2 COL1A1 COL3A1 JUNB ACAN PRKCA VHL HIF1A RELA COL2A1 IBSP JUND FGF23 VEGFA FOSB PIK3CA SPP1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260410%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 LHX1 GFRA1 ROBO2 RET ROBO1 WT1 CTNNB1 HOXC11 HSPB11 GLI3 FOXC2 ALDH1A2 GDNF FOXC1 SOX11 GREM1 SLIT2 BMP4 SPRY1 HNF1B SOX17 IFT27 GATA3 HOXD11 HOXA11 SALL1 SIX2 PAX2 EYA1 FAT4 RAS SIGNALING%WIKIPATHWAYS_20260410%WP4223%HOMO SAPIENS Ras signaling RAB5A FGFR4 FGFR1 BAD GAB1 ELK1 RASA1 NRAS ARF6 MAP2K2;MAP2K1 RRAS MAPK1 CALML6 JMJD7-PLA2G4B;PLA2G4B HRAS CALML3 MAPK3 CALML4 MAPK10 IGF1R RASA3 GRB2 KRAS SOS1 RAF1 FGFR3 SOS2 IKBKB TEK AKT1 PIK3CD PRKACA-1 IKBKG RAC3 RAP1B GNG2 RALBP1-1 RAC1 RALGDS GAB2 GNB1 ZAP70 LAT ABL2 NGFR ETS1 PLA2G2A-1 RALA-1 PIK3R2 PIK3R1 EGFR RASGRP1 RAP1A RASGRP4 PLD2 RASGRP3 RASGRF2 RASA2 PTPN11 REL NF1 RALB RAB5B ETS2 KSR2 TIAM1 SHC4 SHC2 FASLG SHC3 PIK3R3 RASGRP2 GRIN2A CALM3;CALM1 CALM2 SYNGAP1 CSF1R GNG10 PAK1 MAPK8 GNG13 PAK2 GNB2 GNB4 GNB3 GNB5 FLT1 RAB5C GNGT1 FLT3 FLT4 PLA2G4A RHOA FOXO4 GRIN2B CDC42 RRAS2 PLD1 MRAS EXOC2 INSR CHUK RAPGEF5 NTRK1 NTRK2 HTR7 PRKACB-1 GNG5 GNG4 BCL2L1 RASSF1 GNG8 NFKB1 RASSF5 KDR EPHA2 GRIN1 PLA1A AKT3 FGFR2 PDGFRB KIT RASAL1 SHOC2 RASAL2 AKT2 RASAL3 TTBK1 PRKCG BRAP RGL1 RASGRF1 PAK3 RGL2 PAK5 RASA4;RASA4B PLAAT3 PAK4 STK4 PLA2G2F PIK3CB PLA2G2E PLA2G2C BUB1B-PAK6;PAK6 KSR1 PDGFRA PRKCB PLA2G2D PLCG2 PLA2G12A PLA2G4F PLCE1 PRKCA PLA2G12B PLA2G4D MET PLA2G1B PLA2G4E PLA2G3 PLA2G5 PLA2G6 PLCG1 RELA MAPK9 PLA2G10;LOC100652777 CALM1 RIN1 ABL1 SHC1-1 PIK3CA AFDN CORI CYCLE%WIKIPATHWAYS_20260410%WP1946%HOMO SAPIENS Cori cycle SLC2A2 PGAM1 SLC2A1 PFKP G6PD TPI1 HK1 TALDO1 GPT GAPDH-1 PGK1 ALDOA SLC2A4 INS;INS-IGF2 GPI LDHA DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP707%HOMO SAPIENS DNA damage response CASP8 MYC CHEK2 CASP3 E2F1 CDC25C CDC25A FANCD2 APAF1 CDK4 CDK1 PML RAD51 TLK1 FAS CHEK1 CDKN1A RPA2 RAD1 RFC1 RAD52 ATRIP RAD17 ATR RAD9A CCND3 CDK5 GADD45B GADD45A GADD45G BAX AKT1 CDK6 CCNE1 BID TP53 MDM2-2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HUS1B CREB1 TLK2 CCNB3 CDK2 CCNE2 CCND1 PMAIP1 RRM2B DDB2 RAD50 MRE11 ATM NBN BRCA1 PIDD1 CCNB1 SMC1A CDKN1B SFN CCNB2 RB1 CCND2 PRKDC ABL1 CASP9 CYCS-1 SESN1 BBC3 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260410%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1G CHRNA3 CACNA1C CHRNB4 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260410%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment TGFB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCL10 HLA-DRA NRP1 BAG3 CXCL12 CSF2RA CSF2 CSF1 CCR5 FAS CCR2 ITGB6 CCL5 CXCR4 CXCR3 CTLA4 FASLG CD86 KDR CD80 VEGFA LAG3 CSF1R IFITM3;IFITM2;IFITM1 CCL13;CCL2 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias RUNX3 SMAD2;SMAD3 FKBP1A ZNF423 SMAD1 HRAS MAPK3 SMAD9 ZEB2 WNT1 SMAD5 SKI JUN LIF BMP4 LTBP1 SKIL FBN1 ENG SMAD7 EGF FOXH1 ZFYVE9 NFKB1 BAMBI FOS SERPINE1 JAK1 NOG TGFB1 SMAD6 FST CREBBP CTNNB1 THBS1 TFE3 EP300 STAT1 STAT3 RUNX2 ITGB6 TGFBR1-1 IFNG ADAMTSL2 LTBP3 SMAD4 ADAMTS10 TGFBR2 LEF1 INHBA TGFBR3 MAPK9 TNF LEFTY2;LEFTY1 TGIF1-1 SPP1 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260410%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ITPR3 RXRA ATP2B1 TPH2 G6PD KCNQ2 KCNQ3 GRIN1 TPH1 NFE2L2 KDM1A ATP2B3 GGT1 ATP2B2 BCL2 KDM6B GCLC CYP27A1 KDM1B GRIN2C ITPR1 CALB1 GRIN2B CACNA1C CYP27B1 ATP2B4 GRIN2D VDR PVALB CHRM1 SLC8A1 ITPR2 GRM5 GSR GRIN2A KDM3A WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260410%WP399%HOMO SAPIENS Wnt signaling and pluripotency MYC AXIN2 WNT16 ESRRB PPP2R3A PPP2R2C PPP2R2B CTBP2 CTBP1 NLK NKD1 NKD2 WNT6 WNT11 DVL1 DVL2 NANOG;NANOGP8 DVL3 WNT1 MAP2K4 WNT2 NFYA-1 WNT3 FZD1 JUN PPP2CB;PPP2CA WNT10B TCF7L2 WNT10A FZD3 MAPK10 TCF7L1 FZD2 CCND3 FZD5 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A FOSL1 TPTEP2-CSNK1E;CSNK1E TP53 LRRK2 PPP2R3B CREBBP LRP5 LRP6 EP300 PPP2R1A LEF1 MAP3K7 POU5F1;POU5F1B MMP7 PPP2R5C RHOA PRKCZ PAFAH1B1 RACGAP1 FOXD3 LDLR CTNND1 WNT4 FZD4 GSK3B TCF7 CCND1 CTNNB1 PTPA WNT9B CD44 PRKCG PPARD ZBTB33 PRKCQ WNT3A PRKD1 WNT5A PRKCH AXIN1 PRKCB PRKCE FBXW2 PRKCD PPM1J PRKCA APC WNT2B PPP2R1B PPP2R2A;PPP2R2D FZD10 CCND2 MAPK9 PRKCI PLAU SOX2 WNT5B PPP2R5E GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260410%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis SLC2A5 PKLR PGAM1 HK2 GCK HK1 TPI1 ALDOB PGAM2 ENO1 GAPDH-1 PGK1 ALDOA PFKM GOT1-1 PDHA1 G6PC1 SLC2A4 MPC1 LDHA SLC2A2 PKM MDH2 SLC2A1 ENO2 ENO3 PFKP PC ALDOC LDHA;LDHC DLD GOT2-1 PCK1 FBP1 MPC2 FBP2 LDHB MDH1 PFKL DLAT LDHAL6B HK3 GPI FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260410%WP3407%HOMO SAPIENS FTO obesity variant mechanism PPARGC1A IRX5 IRX3 FTO UCP1 PRDM16 TBX1 ARID5B}