PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 96%10225211 Pre-NOTCH Transcription and Translation Prkci Elf3 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling Ppp1ca Adcy5 Adcy6 Ppp2cb Ppp2ca Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Ppp2r5d Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Gnaq Gng7 Pde4d Gng8 Gngt1 Gnat3 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Cdk5 Pde1b Pde1c Gnb2 Gnb1 Pde1a Gnb4 Gnb3 Gnb5 Gng11 Plcb4 Plcb3 Mapk1 Pla2g4a Pdyn Plcb2 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME DATABASE ID RELEASE 96%10223491 SLC-mediated transport of neurotransmitters Slc25a22 Slc6a2 Slc17a7 Slc6a1 Slc17a8 Slc6a4 Slc6a3 Slc17a6 Slc22a2 Slc6a19 Slc6a5 Slc22a1 Slc32a1 Slc6a7 Slc6a15 Slc6a9 Slc6a14 Slc6a11 Slc6a13 Slc6a20 Slc25a18 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%10223741 Surfactant metabolism Slc34a1 Adra2a Adora2b Adgrf5 Adora2a Adra2c Ctsh Slc34a2 Dmbt1 Sftpa1 Ttf1 Lmcd1 Sftpb Napsa Sftpd Sftpc Ccdc59 Abca3 P2ry2 Gata6 Zdhhc2 Ckap4 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224927 Regulation of TP53 Expression Tp53 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-110362.1 POLB-Dependent Long Patch Base Excision Repair Parg Polb Fen1 Parp2 Parp1 Apex1 Adprs Lig1 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-RNO-8878171.1 Transcriptional regulation by RUNX1 H2ab2 Arid1a Arid1b Lmo2 Lmo3 Ccnh H2ac4 Serpinb13 Zfpm1 Actl6a Actl6b Smarce1 Gata3 Gata1 Gata2 Setd1b Setd1a Ring1 Abl1 ENSRNOG00000066901 Tp73 Ccnd2 Phc2 Cbx6 Ccnd3 Phc1 Cbx4 Cbfb Ccnd1 Cbx2 Esr1 Phc3 Kmt2d Crebbp Cdk7 Cdk6 Kmt2a Kmt2b Kmt2c H2ac18 Tcf3 Sin3a Sin3b Csnk2a2 Ctsk Ctsl Csnk2a1 Bmi1 Mnat1 Pbrm1 Prmt6 Hist1h2bq Prmt1 Smarcb1 Hdac1 Wdr5 Ash2l Yaf2 Csnk2b Pax5 H2aj Elf1 Elf2 Tal1 Smarca2 Psma4 Smarca4 Foxp3 Psma3 H3-3b Yap1 Hist3h2ba Psma6 Ep300 Psma5 Rnf2 Psma2 ENSRNOG00000068602 Psma1 Itch Rps27a Smarcd1 Psmd12 Tcf12 Psmd11 Smarcd3 Pcgf5 Psmd14 Smarcd2 Psmd13 Ptpn11 H2bc18 Runx1 Kat2b H2az2 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Pml Psmb6 Smarcc1 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 CAM PATHWAY%REACTOME%R-RNO-111997.1 CaM pathway Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Prkar2b Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10223803 Sialic acid metabolism St8sia6 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 St3gal6 St6galnac2 St3gal4 St3gal5 St3gal2 St3gal3 Slc35a1 St3gal1 Nanp St6gal1 Glb1 St6gal2 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%10224003 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate Adhfe1 L2hgdh D2hgdh REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-RNO-9909648.1 Regulation of PD-L1(CD274) expression Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Rbbp4 Rbbp7 Mib2 Pdcd1lg2 Prkab2 Prkab1 H2ab2 H2ac4 ENSRNOG00000066901 Ccnd1 Kmt2a Kmt2c H2ac18 Csnk2a2 Csnk2a1 Hist1h2bq Wdr5 Ash2l Csnk2b H2aj Psma4 Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 Skp1 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-RNO-419408.1 Lysosphingolipid and LPA receptors Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%10222759 Mitochondrial transcription initiation Polrmt Tfb2m Tfam NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-RNO-375165.1 NCAM signaling for neurite out-growth Creb1 Spta1 St8sia4 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Mapk3 Sptan1 Sptbn5 Rps6ka5 Nras Sptbn4 Mapk1 Grb2 Fyn Kras Sos1 Hras St8sia2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%10222839 Toll Like Receptor 5 (TLR5) Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%10224273 Elastic fibre formation Tgfb2 Tgfb3 Loxl2 Ltbp3 Ltbp2 Loxl1 Furin Ltbp4 Fbln2 Loxl4 Ltbp1 Loxl3 Fbln5 Efemp2 Mfap4 Mfap5 Mfap2 Itgb8 Itgb6 Bmp7 Gdf5 Bmp4 Itgb1 Bmp2 Lox Itgb3 Fbn1 Eln Itga8 Itgav Bmp10 Vtn Tgfb1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-RNO-381070.1 IRE1alpha activates chaperones Ern1 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223831 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a4 Slc13a1 DEPURINATION%REACTOME DATABASE ID RELEASE 96%10222431 Depurination Acd Terf1 Hist1h2ai Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Terf2 H2bc1 Neil3 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10225011 Rab regulation of trafficking Sytl1 Tbc1d25 Tbc1d24 Arf6 Map1lc3b Rab21 Chml Rab9a Rab9b Dennd2a Rab1A Dennd2c Ric1 Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Rgp1 Ankrd27 Dennd3 Rab3il1 Madd Akt3 Akt2 Akt1 Sbf2 Sbf1 Optn Rab11b Rab11a Rab31 Rab35 Rab38 Tsc2 Tsc1 Rab3gap2 Rab3gap1 Dennd1a Rab1b Ulk1 Dennd1b Trappc2l Dennd1c Rin3 Gabarap Rin1 Rin2 Mon1b Dennd6a Mon1a Dennd6b Rab5a Rab4a Trappc10 Rabgap1 Rab33b Rab33a Tbc1d2 Hps1 Tbc1d7 Gabarapl2 Ccz1 Hps4 Trappc12 Trappc11 Trappc13 Rab3a Rinl Gapvd1 Als2cl Gdi1 Rabgef1 Gdi2 Chm Rab7a Rab7b Dennd4c Dennd4a Dennd4b Ywhae Rab27a Rab39a Tbc1d14 Rab27b Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Trappc6b Trappc6a Trappc9 Trappc8 Tbc1d10c Trappc5 Trappc4 Trappc3 Dennd5a Trappc2 Tbc1d10b Trappc1 Rab6b Tbc1d10a Rab6a Rab5c Rab5b Dennd5b Als2 Rab3ip CREATINE METABOLISM%REACTOME%R-RNO-71288.1 Creatine metabolism Gamt Ckmt1 Slc6a7 Ckmt2 Gatm Slc6a8 Ckm Slc6a11 Slc6a12 Ckb PURINE SALVAGE%REACTOME%R-RNO-74217.1 Purine salvage Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Adk Gmpr Hprt1 Dck Aprt Ada Dguok EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-RNO-3928663.1 EPHA-mediated growth cone collapse Fyn Lyn Yes1 Src Rhoa Ngef UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223823 Unblocking of NMDA receptors, glutamate binding and activation Grin1 Grin2d Grin2c Grin2b Grin2a Lrrc7 Gria4 Gria3 Camk2g Camk2d Calm3 Gria2 Camk2b Dlg1 Dlg2 Gria1 Actn2 Dlg3 Dlg4 Camk2a Nefl TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%10225435 TGFBR3 regulates TGF-beta signaling Tgfb2 Tgfbr3 Gipc1 Arrb2 Arrb1 Tgfbr1 Tgfbr2 Tgfb1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223563 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Esr1 Atad2 Lhb Cga TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-RNO-202430.1 Translocation of ZAP-70 to Immunological synapse Zap70 RT1-Db2 Cd3g Cd247 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Ptpn22 RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-RNO-9732724.1 IFNG signaling activates MAPKs Ifngr2 Ifngr1 Mapk1 Raf1 Jak2 Mapk3 Ifng LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 96%10224365 Metabolism of Angiotensinogen to Angiotensins Cpb2 Cpa3 Atp6ap2 Ctsd Ace Mme Ctsg Gzmf Agt Ren1 Ace2 Enpep Ctsz Cma1 Ces1d Cpb1 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA Hadha Hadhb Acadl THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome Aim2 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine Glyatl3 Acsm2 Acsm4 Acsm5 Glyat ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 96%10225491 Antigen processing: Ub, ATP-independent proteasomal degradation Psmb6 Psmb6l1 Psmb1 Psmb3 Psmb2 Psma4 Psma3 Psme2 Psme1 Psma7 Psma6 Psmb9 Psma5 Psmb10 Psma2 Psmb8 Psma1 Psmb5 Psmb4 Psmb7 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223625 Orexin and neuropeptides FF and QRFP bind to their respective receptors Npffr1 Npffr2 Npff Hcrtr2 Hcrtr1 Qrfprl Qrfpr Qrfp Hcrt BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-RNO-9026762.1 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Gstm4 Ltc4s NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%10224573 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Dkk1 Dkk2 Dkk4 Kremen2 Kremen1 Lrp6 Sost INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling Inpp5d Pik3ca Jak2 Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Grb2 Pik3r2 Pik3r3 Inppl1 Sos1 Pik3cd RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP Eif2b3 Eif2b2 Eif2s3 Eif2b5 Eif2b4 Eif2s2 Eif2b1 Eif2s1 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%10225287 tRNA modification in the mitochondrion Yrdc ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 96%10225157 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3r5 Pik3cg Irs2 Pik3ca Jak2 Epor Pik3cd Lyn Pik3r1 Epo Pik3cb Gab1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 96%10224401 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 96%10223473 Biosynthesis of specialized proresolving mediators (SPMs) Alox12 Cyp3a9 Alox5ap Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp3a2 Ptgs2 Gstm4 Ltc4s NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism Nup133 Nup210 Nup155 Nup153 Ddx20 Snrpepl2 Wdr77 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 Snrpg Gemin5 Snrpb Nup58 Gemin8 Nup37 Pom121 Prmt5 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Smn1 Nup160 Rae1 Snupn Ndc1 Snrpd1 Clns1a Nup85 Nup42 Nup62 Nup43 Nup88 Gemin7l1 Aaas Snrpd3 Ranbp2 Nup214 Gemin2 PREDNISONE ADME%REACTOME%R-RNO-9757110.1 Prednisone ADME Cyp3a9 Akr1c18 Akr1c12l1 Akr1c19 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Akr1c21 Abcb1 Ugt2b1 Hsd11b1 Hsd11b2 Ugt2b7 Cyp3a1 AC114845.1 Ugt2b34l1 Cyp3a62 Ugt2b Serpina6 Cyp3a2 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Ugt2b17 Ugt2b37 Ugt2b15 Akr1c9 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-RNO-110330.1 Recognition and association of DNA glycosylase with site containing an affected purine Acd Terf1 Hist1h2ai Ogg1 H2aj Terf2ip Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Terf2 H2bc1 Neil3 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%10223411 Presynaptic depolarization and calcium channel opening Cacnb3 Cacnb4 Cacnb1 Cacna1e Cacnb2 Cacna1a Cacna1b Cacna2d3 Cacng4 Cacna2d2 Cacng2 CHYLOMICRON ASSEMBLY%REACTOME%R-RNO-8963888.1 Chylomicron assembly Sar1b Apoe Apoa4 P4hb Apob Mttp Apoc2 Apoa1 Apoc3 Apoa2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-RNO-113418.1 Formation of the Early Elongation Complex Polr2j Ctdp1 Ncbp2 Ncbp1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Nelfcd Mnat1 Ccnh Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe GPCR LIGAND BINDING%REACTOME%R-RNO-500792.1 GPCR ligand binding Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 App Ednrb Ednra Sct Rrh Ptgdr Htr4 Apln Trhr Tas2r39 Htr6 Oprd1 Htr7 Tas2r38 C3ar1 Crhbp Galr2 Galr3 Galr1 Cmklr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Ppbp Fpr1 Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Vipr2 Nln Vipr1 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Ppy Tas2r135 Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Brs3 Ptger4 Tas2r7 Gabbr1 Ptger2 Ptger3 Fshr Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Crhr1 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr1 Agtr2 F2 Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ghrh Ptgdr2 Rho Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ptgdrl Ccl27 Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Pdyn Mc3r P2ry13 P2ry12 Ccl20 Gng10-ps1 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Tas2r40 Fpr2l1 Tas2r41 Cd55 F2rl2 F2rl3 Hcar1 Prokr2 Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Oprm1 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb2 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Gng3 Uts2 Mc5r Prlh Pomc Tacr1 Gng5 Tacr3 Gng4 Tacr2 Anxa1 Cxcl11 Gng7 Hebp1 Calcr Gng8 Gngt1 Cxcl12 Casr Cxcl10 C5ar2 F2r C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Gnb2 Bdkrb1 Gnb1 Ffar2 Nts Gnb4 Kng1 Gnb3 Calcb Gnb5 Gng11 Chrm1 Calca Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Adra2a Opn5 Adora2b Sucnr1 Lhb Pyy Adora2a Cga Adora1 Adra2c Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh P2ry2 Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Insl3 Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Agt Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Npffr1 Tas2r107 Npffr2 Gpr37l1 Npff Ackr3 Hcrtr2 Ackr4 Hcrtr1 Cck Qrfprl Cnr1 Qrfpr Ackr2 Qrfp Cnr2 Hcrt Uts2r Taar8c Sst Oprk1 Vip Tshb METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se Scly Mat1a NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-RNO-9759194.1 Nuclear events mediated by NFE2L2 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Crebbp Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Srxn1 Psmb6l1 Prdx1 Psmd7 Nfe2l2 Psmd6 Psmd8 Psmd2 Psma4 Prkaa2 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-RNO-76042.1 RNA Polymerase II Transcription Initiation And Promoter Clearance Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i REGULATION OF BACH1 ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225359 Regulation of BACH1 activity Bach1 FCGR ACTIVATION%REACTOME%R-RNO-2029481.1 FCGR activation Lyn Yes1 Src Fyn ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr Cd3g ENSRNOG00000065564 Hck ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes Catsperd Catsper4 Catsper2 Catsperb Hvcn1 Catsper3 Catsper1 Kcnu1 Catsperg METHYLATION%REACTOME DATABASE ID RELEASE 96%10222323 Methylation Mtr Cyp1a2 As3mt Ahcy Comt Mtrr Gsto1 Tpmt Mat2a Mat2b Mat1a ERK1 ERK2 PATHWAY%REACTOME%R-RNO-5684996.1 ERK1 ERK2 pathway Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Spta1 Fgf17 Fgf18 Ptpra Pea15 Fgf19 Ncam1 Braf Sptb Sptbn1 Shoc2 Sptbn2 Mark3 Ptk2 Fgf10 Hbegf Mapk3 Mras Sptan1 Sptbn5 Artn Lypla1 Gfra1 Nras Sptbn4 Ralgdsl1 Grb2 Gfra2 Gfra4 Fyn Rap1a Kras Rap1b Sos1 Tyk2 Hras Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Il6st Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Dusp4 Fgf9 Lamtor3 Lamtor2 Dusp7 Hgf Dusp6 Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Il6 Gdnf Pdgfrb Pdgfra Nf1 Il6r Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Itgb3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk1 Mapk1 Ppp2cb Ppp2ca Calm3 Ppp2r5d Ppp2r1b Ppp2r1a Src Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Arrb2 Arrb1 Raf1 Jak2 Pik3ca Shc1 Il2ra Il2rb Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Ptpn11 Irs2 Rbx1 Cul3 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism Tkfc Aldh1a1 Glyctk Sord Aldob Akr1b1 Khk FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-RNO-163210.1 Formation of ATP by chemiosmotic coupling Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Mt-atp6 Atp5mc1 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 96%10221925 Mitotic G1 phase and G1 S transition Ppp2cb Ppp2ca Rbbp4 Ppp2r1b Ppp2r1a Lyn Src Jak2 Pola2 Ccnh Pola1 Prim2 Prim1 Abl1 Ccnd2 Ccnd3 Ccnd1 Cdk7 Cdk6 Mnat1 Hdac1 Psma4 Ccna1 Akt3 Psma3 Akt2 Ccna2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Ppp2r3b Psmd11 Cdkn2b Cdkn2d Psmd14 Cdc25a Psmd13 Orc4 Orc6 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Gmnn Psmb5 Ptk6 Psmb4 Cdc7 Psmb7 Cdc6 Psmb6 Ppp2r2a Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Dyrk1a Tfdp2 Tfdp1 Cks1b Cables1 Lin52 Rbl2 Lin54 Psma7 Rbl1 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Pole4 Lin9 Rpa1 Rpa2 Wee1 Lin37 Ubb Rpa3 E2f1 Ubc E2f2 E2f3 E2f4 Psmb6l1 E2f5 Cdkn1b Psmd7 Pole Rb1 Cdkn1c Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdk4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222781 MTOR signalling Prkab2 Prkab1 Lamtor3 Lamtor2 Rptor RragB Fkbp1a Prkaa1 Ppm1a Eif4ebp1 Prkaa2 Mtor Stradb Akt3 Rps6kb1 Akt2 Rheb Akt1 Cab39 Strada Pgk1 Slc38a9 Lamtor5 Akt1s1 Prkag3 Lamtor4 Prkag1 Rraga Prkag2 Eef2k Tsc2 Lamtor1 Tsc1 Rragc Rragd Rps6 Stk11 Eif4e Ywhab Mlst8 Cab39l SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10225127 Selenocysteine synthesis Sephs2 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-RNO-5654712.1 FRS-mediated FGFR4 signaling Fgf16 Fgf17 Fgf18 Fgf19 Frs2 Frs3 Nras Grb2 Kras Klb Sos1 Hras Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%10222979 Glutathione conjugation Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Chac1 Chac2 Gstm7 Gstm5 Gstk1 Ggct Gstm1 Gclc Gstm2 Mgst3 Gsto2 Esd Cndp2 Mgst2 Mgst1 Gclm Ggt1 Ggt5 Ggt7 Ggt6 Gstm4 Hpgds Gss Gstp1 Gstt2 Akr1a1 Gstt1 Oplah Gsto1 Gstz1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%10223867 Smooth Muscle Contraction Tln1 Calm3 Myl12b Pxn Myl10 Pde5a Vcl Gucy1b1 Gucy1b2 Pak1 Itga1 Lmod1 Pak2 Tpm4 Tpm2 Cald1 Tpm1 Rlc-a Mylk Gucy1a1 Gucy1a2 Myl7 Myl11 Myl9 Sorbs3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-RNO-72764.1 Eukaryotic Translation Termination Apeh TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis Rpa1 Rpa2 Rpa3 Terf2 Lig1 Acd Terf1 Fen1 Rfc5 Terf2ip Pold2 Tinf2 Pold1 Rfc3 Pot1 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Chtf8 Blm Wrn Chtf18 Ctc1 Stn1 Ten1 Dscc1 Dna2 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-RNO-5693532.1 DNA Double-Strand Break Repair Blm Wrn Mapk8 Dna2 Rif1 Ppp4r2 Paxip1 Pias4 Ube2n Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Lig3 Lig4 Sirt6 Rad51c Baz1b Rad51b Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Prkdc Palb2 Firrm Tp53 Ppp4c Lig1 Nhej1 Clspn Rad17 Kpna2 Fen1 Xrcc6 Parp2 Xrcc3 Parp1 Rfc5 Slx1b Pold2 Xrcc2 Pold1 Tdp2 Rfc3 Xrcc5 Rfc4 Pcna Tdp1 Xrcc4 Rfc1 Xrcc1 Atm Rfc2 Atr Bap1 Pold4 Tp53bp1 Pold3 Apbb1 Kdm4b Kdm4a Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 Abl1 Brcc3 ENSRNOG00000066901 Smarca5 Ppp5c Polq Herc2 Rnf168 Sumo1 ABRAXAS1 Polm Sumo3 Rnf8 Dclre1c Rhno1 Slx4 Nsd2 Spidr Rad51 Rad50 Rad52 Eya2 Eya1 Ercc1 Eya4 Ercc4 Babam1 Eya3 Babam2 Topbp1 Rbbp8 Ubxn1 Brca2 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Poll Rad1 Polh Ccna1 Ccna2 Hist3h2ba Rps27a H2bc4 Hist1h4m H2bc1 Uba52 Pole3 Pole2 Pole4 Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Cdk2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%10224271 Molecules associated with elastic fibres Tgfb2 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Fbln2 Ltbp1 Fbln5 Efemp2 Mfap4 Mfap5 Mfap2 Itgb8 Itgb6 Bmp7 Gdf5 Bmp4 Itgb1 Bmp2 Itgb3 Itga8 Itgav Bmp10 Vtn Tgfb1 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 96%10223389 Metabolism of amine-derived hormones Duox1 Tph1 Ddc Pnmt Duoxa1 Duoxa2 Cav1 Asmt Txndc11 Dio1 Dio2 Dio3 Dbh Cga Duox2 Tpo Th Iyd Slc5a5 Tshb Aanat Tph2 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Orc4 Orc6 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Psma7 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10225423 Regulation of MITF-M-dependent genes involved in apoptosis Sin3a Hint1 Mitf Hdac1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-RNO-9023661.1 Biosynthesis of E-series 18(R)-resolvins Gpx4 Alox5 Lta4h Alox15 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 96%10221977 Cell Cycle Checkpoints Ywhag Spdl1 Nup133 Zfp385a Bub1 Itgb3bp Gsk3b Gtse1 Zwilch Ppp2r5b Ppp2r5a Ube2n Ppp1cc Fbxw11 Ppp2r5e Mapk14 Mapk11 Ywhab Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Ccne1 Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Cdc25a Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Orc3 Skp1 Orc2 Cdc20 Psmb5 Psmb4 Cdc7 Psmb7 Cdc6 Psmb6 Ccnb1 Psmb1 Mcm7 Psmb3 Mcm8 Psmb2 Dbf4 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Mcm3 Mcm4 Aurkb Psmc5 Mcm5 Psmc2 Mcm10 Psmc1 Mcm2 Psmc4 Psmc3 Anapc5 Rpa1 Anapc4 Rpa2 Anapc1 Anapc2 Wee1 Rpa3 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Cdkn1b Psmd7 Ywhae Psmd6 Psmd8 Plk1 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 Ppp2cb Ppp2ca Ppp2r5d Ppp2r1b Ppp2r1a Blm Wrn Dna2 Pias4 Mre11 Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Tp53 Clspn Rad17 Rfc5 Rfc3 Rfc4 Atm Rfc2 Atr Tp53bp1 Exo1 Rmi2 Rmi1 Brip1 Brcc3 ENSRNOG00000066901 Herc2 Rnf168 ABRAXAS1 Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Hist3h2ba Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Sfn Rps27 H2bc4 Plk3 Hist1h4m Rcc2 H2bc1 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Phf20 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Csnk1a1 B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Pkmyt1 Clip1 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Rbx1 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Cop1 Mdm4 Ndc80 Nup43 Ywhaq Ywhah Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e Ywhaz ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization Pdpk1 ENSRNOG00000070986 Lat2 Pik3ca Shc1 Gab2 Lyn Pik3r1 Pik3cb Pik3r2 Grb2 Sos1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-RNO-9025106.1 Biosynthesis of DPAn-6 SPMs Alox12 Alox15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 96%10223319 TCF dependent signaling in response to WNT Ppp2cb Ppp2ca Gsk3b Ctnnb1 Sox3 Wnt5a Sox9 Sox7 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Tnks2 Ppp2r5d Hecw1 Xiap Klhl12 Axin1 Axin2 Rnf43 Tcf7 Dvl1 Dvl2 Dvl3 Sox13 Tcf7l1 Wnt1 Tcf7l2 Fzd1 Fzd2 Ppp2r1b Fzd5 Ppp2r1a Fzd4 Fzd6 Sox17 Fzd8 Bcl9l Bcl9 Cdc73 Rnf146 Cby1 Znrf3 Ctbp1 Amer1 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Wnt8b Smurf2 Wnt8a Sry3 Ppp2r5b Lef1 Ppp2r5a Dact1 Sry Leo1 Ryk Ctnnbip1 Apc Lgr5 Lgr6 Frat2 Pip5k1b Frat1 Ppp2r5e Crebbp Kmt2b Csnk2a2 Csnk2a1 Dkk4 Kremen2 Kremen1 Hdac1 Wdr5 Lrp6 Ash2l Sost Dkk1 Dkk2 Csnk2b Cav1 Psma4 Smarca4 Psma3 Akt2 Akt1 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Rbbp5 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul3 Csnk1e Ywhaz REGULATION OF CDH1 FUNCTION%REACTOME%R-RNO-9764561.1 Regulation of CDH1 Function Ctnnb1 Ctsl Psma4 Psma3 Psma6 Src Psma5 Psma2 Psma1 Rps27a Psmd12 Fyn Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Ctsb Cbll1 Ctss Cdh1 Psmc5 Ctnna1 Psmc2 Rack1 Psmc1 Eps15 Psmc4 Dnm2 Psmc3 Jup Mtbp Ctnnd1 Banp Ubb Ubc Psmb6l1 Psmd7 Vcl Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-RNO-159230.1 Transport of the SLBP Dependant Mature mRNA Nup133 Nup210 Ncbp2 Nup155 Ncbp1 Nup153 Nup93 Nup50 Alyref Nxf1 Slbp Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Eif4e Ranbp2 Nup214 INFLAMMASOMES%REACTOME%R-RNO-622312.1 Inflammasomes Nlrp3 Txn Mefv Pstpip1 Nlrp1a Hsp90ab1 Aim2 P2rx7 Bcl2l1 Pycard Panx1 Txnip Sugt1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling Rps27a Uba52 Tbk1 Irf3 Mavs Rig1 Ubb Tax1bp1 Ikbke Ubc Cyld Nlrx1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-RNO-1638074.1 Keratan sulfate keratin metabolism Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Ogn St3gal6 St3gal4 St3gal2 St3gal3 St3gal1 Glb1 Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Gns B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Glb1l2 Fmod Galns Hexa Hexb B3gnt3 B4gat1 Lum PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224157 PI3K events in ERBB2 signaling Egfr Pik3ca Erbb2 Erbb3 Ereg Nrg2 Nrg3 Hbegf Btc Pik3r1 Grb2 Egf Gab1 TRKA ACTIVATION BY NGF%REACTOME%R-RNO-187042.1 TRKA activation by NGF Ntrk1 Ngf JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 96%10222873 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ikbkg Map3k7 Ube2n Irak2 Irak1 Tab3 Tab2 Tab1 Nod2 Mapk9 Nod1 Mapk10 Map2k7 Mapk8 Traf6 Ripk2 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%10224765 Phospholipase C-mediated cascade; FGFR4 Fgf16 Fgf17 Fgf18 Fgf19 Plcg1 Klb Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4a Pla2g4d Plbd1 Pla2r1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Nck2 Pak1 Rac1 Pak3 Git1 Pak2 Src Rlc-a Fyn Sdcbp Efnb1 Arhgef7 Efnb2 Efnb3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors Ereg Pdpk1 Akr1c18 Akr1c12l1 Akr1c19 Btc Akr1c21 Gnai2 Gnai1 Gnai3 Tle3 Calm3 Akr1c3l1 Akr1c12 S1pr3 Akr1c1 Akr1c13 Akr1c9 Creb1 Gnat3 Ptk2 Mapk3 Hbegf Src Nras Kras Polr2c Hras Polr2a Tgfa Polr2b Polr2g Atf2 Polr2h Areg Polr2e Polr2f Polr2i Polr2j Kat5 Gtf2f2 Gtf2f1 Fos Egfr Hsp90ab1 H2ab2 Jun H2ac4 Kdm4b Gata3 ENSRNOG00000066901 Ppp5c Cbfb Esr1 Crebbp H2ac18 Egf Aldh1a1 Hist1h2bq Prmt1 Hdac1 Pik3ca H2aj Shc1 Cav1 Dhrs4 Pdhx Akt3 Tbp H3-3b Dhrs3 Akt2 Aldh1a2 Akt1 Hist3h2ba Aldh1a3 Gtf2a1 Pik3r1 Ep300 Nrip1 Gtf2a2 Hsp90aa1 ENSRNOG00000068602 Cyp26b1 Pdk4 Pik3r2 Pdk3 Pik3r3 Dhrs9 Ppid Uhmk1 Pdk2 Sdr16c5 H2bc18 Ppidl1 Runx1 Pdk1 Kat2b Nr1h3 H2az2 Nr1h2 Pdhb H2bc4 Kdm1a Hist1h4m Rxrb H2bc1 Rxra Cyp26a1 Sphk1 Hist1h2ai Zdhhc7 Pgr Rxrg Xpo1 Rdh11 Rdh10 Tbl1x Rdh13 Rdh14 Adh4 Pdha1 Adh1 Pdha2 Greb1 Cited1 Strn Prkcz Cav2 Esr2 Abca1 Cdk9 Crabp1 Crabp2 Igf1r Rdh7 Hdac3 Pou2f1 Tbl1xr1 Rara Foxo3 Mmp7 Mmp2 Mmp3 Cdkn1b Zdhhc21 Ppard Fkbp4 Mmp9 Fkbp5 Ptges3 Dld Ncor2 Carm1 Aldh8a1 Gps2 Zfp217 Foxa1 Ncoa3 Rarg Mapk1 Nos3 Fabp5 Yy1 Cyp26c1 Dlat Nr5a2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%10221933 Polymerase switching Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 96%10225277 Signaling by NOTCH4 Notch4 Akt1 Ywhaz TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 96%10224195 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 96%10223183 p75NTR regulates axonogenesis Ngfr Mag Ngf Mcf2 Omg Arhgdia Rhoa Rtn4 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223365 ER to Golgi Anterograde Transport Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Tmem115 Kdelr2 Kdelr3 Sec23ip Sec16b Sec16a Spta1 Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Sptb Cnih2 Sptbn1 Sptbn2 Kdelr1 Arf4 Ctsc Arf3 Sptan1 Sptbn5 Arf1 Ppp6r3 Mia2 Sptbn4 Mia3 Sar1b Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Tgfa Ppp6c Sec31b Gria1 Areg Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Ctsz Rab1b Trappc2l Dync1h1 Trappc10 Dync1i2 Dync1i1 Sec13 Trappc6b Dync1li2 Trappc6a Trappc9 Dync1li1 Trappc5 Dynll1 Trappc4 Dynll2 Trappc3 Trappc2 Trappc1 Ins1 Cd55 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223669 Hormone ligand-binding receptors Fshb Gnrh1 Fshr Gnrhr Gphb5 Lhcgr Lhb Cga Gpha2 Tshr Tshb SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222105 Succinyl-CoA Biosynthesis Dld AC132020.1 Ogdh Dlst Kgd4 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%10223631 Metabolism of cofactors Idh1 Pdss2 Coq8a Pdss1 Coq8b Coq2 Pts Coq3 Gchfr Coq4 Coq5 Coq6 Hpdl Akt1 Coq7 Spr Hsp90aa1 Coq9 Stard7 Nos3 Aco1 Calm3 Prkg2 Gch1 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%10222253 Formation of editosomes by ADAR proteins Adarb1 Adar CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%10222895 Cyclin A B1 B2 associated events during G2 M transition Ccnb1 Ppp2r2a Ppp2cb Xpo1 Ppp2ca Cdk7 Mnat1 Wee1 Fzr1 Pkmyt1 Plk1 Ppp2r1b Sgo1 Ppp2r1a Ccna1 Cdc25c Ccna2 Ccnh Cdk2 Cdk1 Ppp2r3b Bora Foxm1 Ppme1 Cdc25a Lcmt1 Ccnb2-ps2 Mis18bp1 Hjurp Cdc25b Obi1 Ccnb2 Ticrr INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223901 Interleukin-4 and Interleukin-13 signaling Stat6 Il13 Hsp90b1 Socs5 Jak2 Il4 Stat3 Stat1 Jak3 Tyk2 Socs1 Il13ra2 Il4r RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 96%10224791 RAF MAP kinase cascade Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Spta1 Fgf17 Fgf18 Ptpra Pea15 Fgf19 Ncam1 Braf Sptb Sptbn1 Shoc2 Sptbn2 Mark3 Ptk2 Fgf10 Hbegf Mapk3 Mras Sptan1 Sptbn5 Artn Lypla1 Gfra1 Nras Sptbn4 Ralgdsl1 Grb2 Gfra2 Gfra4 Fyn Rap1a Kras Rap1b Sos1 Hras Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Dusp4 Fgf9 Lamtor3 Lamtor2 Dusp7 Hgf Dusp6 Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Gdnf Pdgfrb Pdgfra Nf1 Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Itgb3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Mapk1 Ppp2cb Ppp2ca Calm3 Ppp2r5d Ppp2r1b Ppp2r1a Src Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Arrb2 Arrb1 Raf1 Jak2 Pik3ca Shc1 Il2ra Il2rb Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Irs2 Rbx1 Cul3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-RNO-2534343.1 Interaction With Cumulus Cells And The Zona Pellucida Hyal5 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%10224701 Matriglycan biosynthesis on DAG1 Fktn Pomgnt1 Slc35a1 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 B4gat1 Large1 Large2 SWI SNF CHROMATIN REMODELERS%REACTOME%R-RNO-9932451.1 SWI SNF chromatin remodelers Smarcc1 Ss18 Dpf1 Bicral Bicra Dpf2 Dpf3 Pbrm1 Brd9 Brd7 Actg1 Ss18l1 Smarcb1 Bcl7a Bcl7b Bcl7c Bcl11a Bcl11b Phf10 Smarca2 Arid1a Smarca4 Arid1b Actl6a Smarcd1 Smarce1 Smarcd3 Smarcd2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation Fgf16 Fgfbp3 Fgf17 Fgfbp1 Fgf18 Fgf10 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Fgfr2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling Itgb3bp Ngf Arhgef7 Tiam1 Mcf2l Tiam2 Rac1 Prkci Adam17 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Rhoa Arhgef10 Arhgef12 Ngef Arhgef19 Rps27a Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Ikbkb Psen2 Sos2 Kalrn Ncstn Mapk8 Aph1a Traf6 Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Uba52 Gna13 Arhgef1 Nfkb1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Rela Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Myd88 Plekhg2 Ubb Net1 Arhgef10l Ubc Ripk2 Ywhae Irak1 Nfkbia Rasgrf2 Ngfr Mag Mcf2 Omg Arhgdia Rtn4 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223119 Gap junction degradation Cltb Myo6 Cltc Dab2 Dnm1 Dnm2 Ap2m1 Gja1 Clta P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB Uba52 Prkci Nfkb1 Irak1 Ngf Nfkbia Sqstm1 Rela Rps27a Ngfr Myd88 Ikbkb Ubb Ubc Traf6 Ripk2 PERK REGULATES GENE EXPRESSION%REACTOME%R-RNO-381042.1 PERK regulates gene expression Eif2ak3 Eif2s3 Eif2s2 Eif2s1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-RNO-8850843.1 Phosphate bond hydrolysis by NTPDase proteins Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 INTERLEUKIN-6 SIGNALING%REACTOME%R-RNO-1059683.1 Interleukin-6 signaling Jak2 Tyk2 Stat3 Ptpn11 Stat1 Il6 Socs3 Il6st Cbl Il6r MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 96%10222403 MAPK family signaling cascades Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Spta1 Fgf17 Fgf18 Ptpra Pea15 Fgf19 Ncam1 Braf Sptb Sptbn1 Shoc2 Sptbn2 Mark3 Ptk2 Fgf10 Hbegf Mapk3 Mras Sptan1 Sptbn5 Artn Lypla1 Gfra1 Nras Sptbn4 Ralgdsl1 Grb2 Gfra2 Gfra4 Fyn Rap1a Kras Rap1b Sos1 Tyk2 Hras Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Il6st Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Dusp4 Fgf9 Lamtor3 Lamtor2 Dusp7 Hgf Dusp6 Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Il6 Gdnf Pdgfrb Pdgfra Nf1 Il6r Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Itgb3 Rac1 Pak3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Cdc14a Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk1 Ncoa3 Mapk1 Ppp2cb Ppp2ca Prkaca Prkacb Calm3 Ppp2r5d Pak1 Ppp2r1b Ppp2r1a Pak2 Src Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Arrb2 Arrb1 Raf1 Jak2 Ccnd3 Pik3ca Shc1 Il2ra Il2rb Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Ptpn11 Kalrn Irs2 Xpo1 Rbx1 Foxo1 Septin7 Mapk6 Mapk4 Cdc42ep2 Cdc42ep3 Hspb1 Cdc14b Etv4 Cdc42 Dnajb1 Cul3 Mapkapk5 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10223201 Transport of organic anions Slco2b1 Slco2a1 Slco4c1 SLC16A2 Slco1c1 Avp Slco3a1 Slco1a4 Slco4a1 Slco1b2 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%10225125 Protein localization Phyh Amacr Eci2 Mpv17 Hmox1 Gstk1 Hacl1 Pex26 Sec61gl4 Mlycd Scp2 Pex11b Gnpat Crat Acox1 Acox2 Ech1 Ehhadh Acox3 Ube2d3 Ube2d2 Pipox Acaa1b Tysnd1 Prnp Hsd17b4 Lonp2 Pxmp4 Pxmp2 Hao1 Hao2 Fis1 Pecr Stx1a Dao Acbd5 Pitrm1 Slc27a2 Aldh3a2 Ide Decr2 Crot Emd Hspd1 Nudt19 Acot1 Acot2 Pex2 Pex1 Acot5 Vamp2 App Acot3 Acot4 Cyb5a Ldhd Pex7 Usp9x Acot8 Pex3 Pex6 Pex5 Cat Fxn Serp1 Sgta Abcd1 Baat Ddo Abcd2 Gdap1 Abcd3 Zfand6 Vapa Agps Stx5 Agxt Nudt7 Hmgcl Nos2 Hscb Ndufb8 Atad1 Pex14 Pex13 Pex12 Pex10 Pex19 Ube2j2 Otc Pex16 Idh1 Coq2 Atp5mc3 Dhrs4 Atp5f1b Rps27a Uba52 Ube2d1 Ephx2 Ubb Ubc DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%10221905 DNA Replication Pre-Initiation Kpnb1 Kpna6 Kpna1 H2ab2 Pola2 H2ac4 Pola1 Prim2 Prim1 ENSRNOG00000066901 H2ac18 Hist1h2bq H2aj Psma4 Psma3 H3-3b Ube2s Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 H2bc18 Cdc26 Orc6 Cdc23 Orc1 Orc3 H2az2 Orc2 Cdt1 H2bc4 Gmnn Psmb5 Hist1h4m Psmb4 H2bc1 Cdc7 Psmb7 Cdc6 Psmb6 Hist1h2ai Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Pole Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk2 Cdc16 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-RNO-350054.1 Notch-HLH transcription pathway Kat2a Maml3 Rbpj Hdac2 Hdac5 Hdac4 Maml1 Tbl1x Hdac11 Crebbp Maml2 Ncor2 Hdac10 Notch3 Hdac9 Hdac8 Notch4 Kat2b Hdac3 Tbl1xr1 Hdac1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%10224049 IRAK2 mediated activation of TAK1 complex Rps27a Tab3 Tab2 Map3k7 Uba52 Tab1 Irak2 Ubb Ubc Traf6 RECYCLING PATHWAY OF L1%REACTOME%R-RNO-437239.1 Recycling pathway of L1 Cltc Dnm1 Dpysl2 Src Kif4b Ap2s1 Kif4a Rdx Mapk1 Msn L1cam Dnm2 Dnm3 Ap2a2 Ap2a1 Ap2b1 Numb Sh3gl2 Ezr Ap2m1 Clta BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism Osbpl6 Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Amacr Baat Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Slc10a1 Akr1c19 Fabp6 Nr1h4 Abcc3 Stard5 Akr1c21 Cyp46a1 Scp2 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Acox2 Slc51b Abcb11 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Hsd17b4 Akr1c9 Slc27a2 Ch25h Osbpl3 Slco1a4 Osbpl2 Acot8 Osbpl1a Osbpl7 Slco1b2 Rxra COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade Cpb2 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Masp1 Masp2 C4b C1qb Crp C1qa Cfh Cfi C2 C5ar2 Elane C4 C5ar1 Colec10 C6 C9 Cd46 Cfhr1 C1s C1r Cpn1 Cpn2 Cd19 C1qc ENSRNOG00000069193 AABR07065813.1 F2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 C3ar1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C3 C5 Cd55 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223781 NoRC negatively regulates rRNA expression Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Mbd2 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus Ippk Ipmk Ip6k1 Ip6k2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-RNO-1660516.1 Synthesis of PIPs at the early endosome membrane Fig4 Vac14 Mtmr12 Pi4k2a Mtmr4 Pik3r4 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 96%10224891 Protein lipoylation Dlat Gcsh Lipt1 Lipt2 Nfu1 Ndufab1 Fdx1 Dbt Dlst Lias MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223413 MicroRNA (miRNA) biogenesis Ago3 Ago2 Ago1 Dicer1 Tarbp2 Prkra Ago4 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%10224331 IPs transport between nucleus and cytosol Nup133 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-RNO-69052.1 Switching of origins to a post-replicative state Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Psmb7 Psmb6 Cdc6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222291 Wax and plasmalogen biosynthesis Gnpat Awat2 Awat1 Dhrs7b Far2 Far1 Agps ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans Acan Itga2b Itgb6 Itgb1 Itgb3 Tnc Itga7 Itgax Dmp1 Itga9 Dspp Bcan Vcan Tnn Itga2 Tnr Agrn Tnxb Ncan Dcn Hapln1 Serpine1 Itga8 Itgav Vtn FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222325 Fatty acids Cyp2j16 Adh7 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp2d4 Cyp4b1 Cyp2a2 Cyp2a1 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 ARMS-MEDIATED ACTIVATION%REACTOME%R-RNO-170984.1 ARMS-mediated activation Rap1a Ntrk1 Ngf Crk Kidins220 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190372.1 FGFR3c ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Galnt3 Fgf9 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%10224953 Retrograde transport at the Trans-Golgi-Network Rab43 Tmf1 Sys1 Golga1 Vps51 Vps52 Vps54 Arl1 Rab9a Gcc2 Rab9b Gcc1 Cog1 Usp6nl Cog2 Stx6 Cog3 Ttgn1 Ric1 Cog4 Igf2r Scoc M6pr Vti1a Cog5 Vamp3 Vamp4 Cog6 Stx16 Cog7 Rgp1 Arfip2 Cog8 Rhobtb3 Napa Rabepk Nsf Arfrp1 Napb Napg Rab6b Rab6a Golga4 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%10222121 Pyrophosphate hydrolysis Ppa1 Ppa2 Lhpp PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%10224671 Phase 3 - rapid repolarisation Kcne3 Kcne2 Kcnh2 Kcna5 Akap9 Kcne5 Kcnq1 Kcne4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224095 Inwardly rectifying K+ channels Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Kcnj8 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Kcnj1 Kcnj14 Gnb2 Abcc8 Gnb1 Kcnj11 Kcnj12 Gnb4 Gnb3 Abcc9 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-RNO-5358493.1 Synthesis of diphthamide-EEF2 Dph5 Dph6 Eef2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nos3 Calm3 Pts Gchfr Prkg2 Akt1 Spr Gch1 Hsp90aa1 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines Smarcc1 Hist1h2ai Ccnd1 Wdr77 Rbbp7 H2ac18 Pbrm1 Prmt6 Prmt1 Smarcb1 Wdr5 Prmt5 Smarca2 Arid1a Smarca4 Arid1b Carm1 H2ac4 ENSRNOG00000068602 Actl6a Smarcd1 Actl6b Smarce1 Smarcd3 Smarcd2 Coprs H2ac25 H2bc18 Prmt7 Dnmt3a Prmt3 Cdk4 Rps2 Hist1h4m THREONINE CATABOLISM%REACTOME%R-RNO-8849175.1 Threonine catabolism Rida Sds Sdsl PHOSPHORYLATION OF EMI1%REACTOME%R-RNO-176417.1 Phosphorylation of Emi1 Ccnb1 Plk1 Fbxo5 Fzr1 Cdc20 Cdk1 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10225051 Regulation of Apoptosis Oma1 Opa1 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223935 Activation of Na-permeable kainate receptors Grik2 Grik1 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224455 Scavenging by Class A Receptors Apoe Hsp90b1 Msr1 Calr Apob Apoa1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9840310.1 Glycosphingolipid catabolism Arsa Smpd2 Neu2 Smpd3 Neu3 Smpd4 Neu4 Smpd1 Neu1 Gba1 Gba3 Gba2 Enpp7 Galc Asah2 M6pr Asah1 Sts Gm2a Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Glb1 Arsb Sumf2 Ctsa Glb1l Psap Glb1l3 Glb1l2 Hexa Hexb OPSINS%REACTOME%R-RNO-419771.1 Opsins Opn1mw Rho Rrh Opn4 Opn3 Opn1sw Opn5 Rgr CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Xiap Pxn Src Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Pard3 Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Cdh8 Vcl Hdac2 Jak2 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Pard6b Il6 Pard6a Kmt5a H2ac4 Sec11c Amot Sec11a Il6r Fermt2 Prkcsh Flna Flnc Sirt1 Pard6g Vasp Itga6 Zmym2 Cadm3 Sp1 ENSRNOG00000066901 Cdh24 Cadm2 Cadm1 Rnf19b Tesk1 F11r Pomt1 Sdk1 Hace1 Dnttip1 Pomt2 Stat3 Fblim1 Furin Parvb Parva Pcsk7 Pcsk6 Sdk2 Ilk Birc2 H2ac18 Adam19 Afdn Ctbp2 Plec Csnk2a2 Dst Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Cdh18 Itgb1 Cdh17 Cd151 Cdh15 Hist1h2bq Itgb4 Cdh13 Cdh12 Hdac1 Actn1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 Megf11 H2aj Canx Tiam1 Arhgap32 Spcs3 Prkci Rac1 Spcs1 Spcs2 Psma4 Smarca4 Farp2 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Vav2 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Arhgef6 Psmb6 Hist1h2ai Psmb1 Arhgef4 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%10222743 Attachment of GPI anchor to uPAR Pgap1 Pigs Pigu Pigt Gpaa1 Pigk Plaur DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%10223321 Disassembly of the destruction complex and recruitment of AXIN to the membrane Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Gsk3b Apc Ctnnb1 Frat2 Frat1 Csnk1a1 Ppp2r5e Ppp2r5d Axin1 Lrp6 Dvl1 Dvl2 Dvl3 Wnt1 Fzd1 Cav1 Fzd2 Ppp2r1b Fzd5 Ppp2r1a Amer1 Wnt8b Wnt8a EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-RNO-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes Ncoa2 Kmt2d Crebbp Kmt2a Kmt2b Kmt2c H2ac18 Men1 Hist1h2bq Wdr5 Ash2l H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 Tasp1 Akap8l Cxxc1 Kat8 H2bc18 Med27 Med12 Kat2b Med1 H2az2 Yeats2 Rbbp5 Med13 H2bc4 Med14 Hist1h4m Wdr82 H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Paxip1 Pparg Med6 Kat14 Phf20 Mbip Hcfc1 Med16 Tbl1x Med17 Hcfc2 Dr1 Kansl3 Kansl1 Kansl2 Phf20l1 Ajuba Bod1l1 Pagr1 Tada3 Med30 Tada2a Med31 Ppargc1a Ppargc1b Mcrs1 Zzz3 Hdac3 Sgf29 Psip1 Tbl1xr1 Ogt Kat2a Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Setd1b Setd1a Abl1 ENSRNOG00000066901 COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis Ppcs Dcakd Ppcdc Coasy Pank3 Pank2 Pank1 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%10222705 Amino Acid conjugation Glyatl3 Acsm2 Acsm4 Acsm5 Glyat HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state Grk2 Psma4 Psma3 Psma6 Psma5 Cdc73 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Dzip1 Psmd6 Gpr161 Psmd8 Ihh Gli1 Psmd2 Gli3 Gli2 Psmd1 Shh Adrm1 Kif7 Rbx1 Evc Smo Spop Ulk3 Smurf1 Cdon Dhh Spopl Ptch1 Evc2 Hhip Sufu Numb Cul3 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%10222797 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Uba52 Tbk1 Irf3 Ikbke Optn Rps27a Ptpn11 Traf3 Tank Ly96 Ticam2 Ubb Sarm1 Irf7 Ubc Ticam1 Cd14 Tlr4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%10223357 Regulation of pyruvate dehydrogenase (PDH) complex Pdp1 Pdpr Pdp2 Dld Pdhx Pdha1 Pdha2 Pdk4 Pdk3 Dlat Pdk2 Pdk1 Pdhb Gstz1 HEME DEGRADATION%REACTOME DATABASE ID RELEASE 96%10222691 Heme degradation Gsta5 Slco2b1 Fabp1 Blvrb Hmox2 Blvra Abcg2 Abcc1 Hmox1 Abcc2 Ugt1a2 Ugt1a1 Ugt1a3 Ugt1a5 Alb Slco1b2 ANDROGEN BIOSYNTHESIS%REACTOME%R-RNO-193048.1 Androgen biosynthesis Hsd3b Lhb Hsd17b3 Cga Cyp17a1 Hsd3b6 Hsd3b5 Srd5a3 Hsd3b1 Srd5a1 Hsd17b12 Srd5a2 Hsd3b5-ps1 Pomc DNA REPLICATION%REACTOME DATABASE ID RELEASE 96%10221907 DNA Replication Polg2 Twnk Gins2 Gins1 Gins4 Gins3 Ssbp1 Polg Polrmt Dna2 Kpnb1 Kpna6 Lig1 Kpna1 Fen1 Rfc5 Pold2 Pold1 H2ab2 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 H2ac4 Pola1 Pold4 Pold3 Prim2 Prim1 ENSRNOG00000066901 H2ac18 Hist1h2bq H2aj Psma4 Ccna1 Psma3 H3-3b Ccna2 Ube2s Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 H2bc18 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 H2az2 Skp1 Orc2 Cdt1 H2bc4 Gmnn Psmb5 Hist1h4m Psmb4 H2bc1 Cdc7 Psmb7 Cdc6 Psmb6 Hist1h2ai Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Pole Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%10225089 Aryl hydrocarbon receptor signalling Ahrr Ahr Hsp90ab1 Ptges3 Arnt2 Arnt GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222497 GPER1 signaling Prkar1a Shc1 Prkar2a Prkar1b Itgb1 Prkar2b Prkaca Prkacb INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 96%10225003 Interaction between PHLDA1 and AURKA Phlda1 Aurka CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%10224135 Cross-presentation of soluble exogenous antigens (endosomes) Psmb6 Psmb1 Psmb3 Psmb2 Psme2 Psme1 Psma7 Psmb9 Psmb10 Psmb8 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fcgr1a Psmb6l1 Psmd7 Cd207 Mrc2 Psmd6 Mrc1 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%10223713 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Dpp4 Gpr119 Ffar1 Gip RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis Peli1 Uba52 Traf2 Birc2 Xiap Ubb Sdcbp Ogt Ubc Casp8 Mlkl Flot2 Flot1 Ripk3 Tradd Cflar Prkn Hsp90aa1 Stub1 Itch Ripk1 Rps27a Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Ube2l3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%10222885 IKK complex recruitment mediated by RIP1 Ikbkg Ube2n Uba52 Ube2d1 Ripk3 Birc2 Ripk1 Rps27a Ube2d3 Chuk Ube2d2 Ly96 Ikbkb Ticam2 Ubb Sarm1 Ubc Ticam1 Cd14 Traf6 Tlr4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375276.1 Peptide ligand-binding receptors F2rl2 F2rl3 Prokr2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Oprm1 Cxcr4 Cxcr5 Oprl1 Uts2 Mc5r Prlh Pomc Tacr1 Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Cxcl10 C5ar2 F2r C5ar1 Aplnr Bdkrb2 Bdkrb1 Nts Kng1 App Tac3 Tac1 Pmch Ccrl2 Gper1 Pyy Ednrb Rln3 Ednra Rln1 Cxcl16 Cxcl13 Apln Trhr Prlhr Oxt Oprd1 Ece1 Ece2 Trh C3ar1 Npy5r Galr2 Galr3 Galr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Npy4r Rxfp1 Cx3cr1 Insl3 Psap Ppbp Fpr1 Nmbr Xcl1 Fpr2 Ccr10 Kiss1 Agt C3 Nln C5 Ccl9 Pnoc Cxcl9 Ccl7 Ppy Ccl6 Ccl5 Nmb Oxtr Ccl4 Ccl3 Xcr1 Ccl1 Cxcl1 Grpr Cxcl2 Cxcl3 Nms Cxcl5 Nmu Uts2b Cckar Npffr1 Npbwr1 Npffr2 Gpr37l1 Npff Ackr3 Hcrtr2 Ackr4 Nmur2 Hcrtr1 Cck Qrfprl Qrfpr Ackr2 Nmur1 Qrfp Ntsr2 Hcrt Uts2r Ntsr1 Sst Oprk1 Brs3 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Edn1 Edn2 Edn3 Cckbr Agtr1 Agtr2 F2 Gpr37 Mc1r Gal Penk Avp Npb Grp Kiss1r Ccl19 Ccl17 Nps Mc4r Ccl11 Ccl12 Npw Npy Pf4 Cx3cl1 Fpr2l3 Prok2 Ccl27 Npsr1 Prok1 Pdyn Mc3r Ccl20 Ccl21 F2rl1 Fpr2l1 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 96%10224763 Phospholipase C-mediated cascade: FGFR1 Fgf17 Fgf10 Plcg1 Fgf2 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-RNO-975634.1 Retinoid metabolism and transport Lrp10 Plb1 Lrp12 Ttr Gpc1 Rdh11 Gpc3 Gpc2 Akr1c18 Gpc5 Akr1c12l1 Gpc4 Akr1c19 Bco2 Bco1 Gpc6 Clps Akr1c21 Pnlip Akr1b10 Rbp4 Apom Rbp2 Rbp1 Sdc1 Lrat Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Agrn Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells Mmp2 Ephb1 Aph1b Ephb2 Ephb3 Ephb4 Tiam1 Ephb6 Mmp9 Rac1 Lyn Yes1 Src Vav3 Fyn Vav2 Psenen Psen1 Psen2 Efnb1 Ncstn Aph1a Efnb2 Efnb3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 96%10224413 MASTL Facilitates Mitotic Progression Mastl Arpp19 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 96%10224333 Synthesis of IPs in the ER lumen Minpp1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-RNO-918233.1 TRAF3-dependent IRF activation pathway Irf3 Irf7 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway Polb Apex1 Xrcc1 Lig3 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 96%10225445 Cellular response to mitochondrial stress Oma1 Eif2s3 Eif2ak1 Yme1l1 Dele1 Eif2s2 Stoml2 Eif2s1 Phb2 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224695 DAG1 glycosylations Pomgnt2 Pomt1 Pomt2 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Fktn Pomgnt1 Slc35a1 Mgat5b B4gat1 B3galnt2 Pomk LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223677 Leukotriene receptors Cysltr2 Cysltr1 Ltb4r Gpr17 Ltb4r2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%10224285 Cysteine formation from homocysteine Cbs Cth INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223493 Integrin signaling Apbb1ip Fgb Fga Fgg Pdpk1 Itga2b Syk Rasgrp1 Csk Tln1 Fn1 Itgb3 Bcar1 Shc1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Ptk2 Akt1 Src Grb2 Rap1a Rap1b Sos1 Crk BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224989 Butyrophilin (BTN) family interactions Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Ppl Xdh REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%10225397 Regulation of CDH1 Expression and Function Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Src Fyn Ctbp1 Ctsb Cbll1 Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Vcl Hdac2 H2ab2 Twist1 Kmt5a H2ac4 Sec11c Sec11a Prkcsh Sirt1 Zmym2 ENSRNOG00000066901 Pomt1 Dnttip1 Pomt2 Furin Pcsk7 Pcsk6 H2ac18 Ctbp2 Csnk2a2 Ctsl Zeb1 Csnk2a1 Hist1h2bq Hdac1 Ganab Csnk2b Mphosph8 H2aj Canx Arhgap32 Spcs3 Spcs1 Spcs2 Psma4 Smarca4 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Ezh2 Dad1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%10223543 Degradation of the extracellular matrix Adamts4 Mmp16 Mmp17 Mmp19 Adam8 Mmp8 Try10 Furin Acan Prss2l1 Ctrb1 Mmp10 Cast Col15a1 Capn15 Col13a1 Plg Klkb1 Col19a1 Phykpl Spp1 Ctsk Try5 Ctsl Cd44 LOC102554637 Capn9 Scube3 Capn8 Scube1 Capn5 Capn7 Capn6 Col25a1 Capn1 Timp1 Capn3 Capn2 Timp2 Prss2 Prss3 Tmprss6 Elane Mmp1b Tpsb2 Prss1 Spock3 Capns1 Capn10 A2m Capn11 Capn12 Capn13 Ctsb Ctss Cdh1 Mmp7 Mmp2 Bcan Mmp3 Mmp9 Dcn Mmp24 Mmp25 Col18a1 Adam15 Ctsd Optc Adam10 Bsg Ctsg Htra1 ENSRNOG00000069479 Mmp20 Mmp11 Col26a1 Mmp12 Mmp13 Mmp14 Cma1 Adamts5 Mmp15 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 96%10222665 Eukaryotic Translation Elongation Eef1d Eef1b2 Eef1g Eef1a1 Eef2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-RNO-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK Creb1 Mmp3 Egfr Mapk3 Hbegf Rps6ka3 Nras Prkca Mapk1 Grb2 Rps6ka1 Kras Gast Sos1 Rps6ka2 Hras Cckbr Mapk7 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Pabpc1 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Eif4ebp1 Rps6 Eif4e DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 96%10223969 Deubiquitination Tnks2 Rce1 ENSRNOG00000067432 Axin1 Axin2 Ide Prkn Rnf146 Ripk1 Tnks Usp34 Usp9x Smurf2 Traf6 Ikbkg Map3k7 Apc Traf2 Tnip2 Nod2 Nod1 Ripk2 Kat2a Nlrp3 Rig1 Nfkbia Cyld Usp14 Usp18 Tab1 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cdc25a Psmd13 Skp2 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Ube2d1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Stambpl1 Psmd8 Nfrkb Myc Psmd2 Foxk2 Foxk1 Psmd1 Vdac2 Adrm1 Yod1 Vdac3 Vdac1 Tfpt Cdk1 Becn1 Tomm70 Otud7a Actr5 Otud7b Yy1 Actr8 Josd2 Josd1 Rnf123 Rnf128 Stam Snx3 Ar Hif1a Zranb1 Cftr Siah2 Keap1 Ino80 Wdr48 Ddb2 Ufd1 Foxo4 Uchl3 Abraxas2 Uchl5 Ifih1 Fkbp8 Ino80e Ino80d Ino80c Ino80b Il33 Wdr20 Mbd5 Mbd6 Adrb2 Uchl1 Nedd8 Atxn3 Atxn7 Suds3 Usp2 Mul1 Usp3 Usp4 Kdm1b Usp5 Usp7 Usp8 Hgs Ruvbl1 Stambp Rad23a Rad23b Tomm20 Tada2b Smad1 Smad2 Smad3 Smad4 Smad7 Otub1 Usp44 Rhoa Usp42 Usp48 Usp47 Stam2 Usp30 Otub2 Vcpip1 Usp33 Usp37 H2ac25 Mysm1 Tnip3 Tnip1 Senp8 Otud3 Usp22 Usp21 Usp20 Usp26 Usp25 Usp24 Usp29 Usp28 Ccp110 Asxl1 Arrb2 Asxl2 Arrb1 Pten Usp12 Tgfbr1 Usp11 Usp10 Usp16 Usp15 Usp13 Usp19 Bard1 Tp53 Clspn Polb H2ac4 Bap1 Actl6a Gata3 Brcc3 ABRAXAS1 Esr1 Birc2 H2ac18 Babam1 Babam2 Brca1 Uimc1 Actg1 Taf9b Taf10 Ep300 ENSRNOG00000068602 Kat2b Hist1h2ai Hcfc1 Tada3 Mcrs1 Ogt Vcp Mdm4 Traf3 Mat2b MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222381 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Acadm Decr1 Eci1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation Fgf17 Tgfbr3 Gipc1 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf5 Fgf8 Fgfr1 Fgf9 SPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9845614.1 Sphingolipid catabolism Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Acer3 Sgpp2 Plpp2 Aldh3a2 Plpp3 Plpp1 Sgpp1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Flrt1 Flrt3 Fgf9 Fgfr1 Flrt2 Fgf17 Pik3ca Shc1 Fgf10 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Kl Fgf23 Fgf22 Gab1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223783 Negative epigenetic regulation of rRNA expression Suv39h1 Rrp8 Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Mbd2 Sirt1 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181430.1 Norepinephrine Neurotransmitter Release Cycle Rims1 Maoa Tspoap1 Syt1 Stx1a Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Slc22a2 Slc22a1 Vamp2 Rab3a TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%10222829 Toll Like Receptor TLR1:TLR2 Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-RNO-5620920.1 Cargo trafficking to the periciliary membrane Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Rab8a Pde6d Ttc8 Nphp3 Lztfl1 Arf4 Mchr1 Rab11a Gbf1 Rho Sstr3 Smo Mkks Unc119b Arl13b Pkd1 Rp2 Asap1 Bbs9 Bbs7 Bbs5 Bbs4 Cct3 Cct2 Bbs10 Bbs12 Thoc2l Cngb1 Rab3ip INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%10223909 Interleukin-2 family signaling Stat3 Stat1 Syk Il15 Il15ra Lck Il9 Il21 Ptk2b Stat5a Stat5b Il9r Inpp5d Jak2 Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Grb2 Pik3r2 Pik3r3 Inppl1 Pik3cd Sos1 Sos2 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism Thtpa Tpk1 Slc19a2 Slc19a3 Slc25a19 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression Cbfb Esr1 Crebbp H2ac18 Tle3 Hist1h2bq Prmt1 Hdac1 H2aj Tbp H3-3b Hist3h2ba Gtf2a1 Ep300 Nrip1 Gtf2a2 Hsp90aa1 ENSRNOG00000068602 Polr2c Polr2a Polr2b H2bc18 Polr2g Runx1 Atf2 Polr2h Kat2b H2az2 Polr2e Polr2f H2bc4 Kdm1a Hist1h4m Polr2i H2bc1 Polr2j Hist1h2ai Pgr Kat5 Gtf2f2 Gtf2f1 Fos Greb1 Cited1 Cdk9 Pou2f1 Fkbp4 Hsp90ab1 H2ab2 Ptges3 Jun Carm1 H2ac4 Zfp217 Foxa1 Ncoa3 Kdm4b Gata3 Yy1 Nr5a2 ENSRNOG00000066901 GASTRULATION%REACTOME DATABASE ID RELEASE 96%10225431 Gastrulation Tfap2c Tfap2a Tfap2b ALPK1 SIGNALING PATHWAY%REACTOME%R-RNO-9645460.1 ALPK1 signaling pathway Rps27a Tab3 Tab2 Map3k7 Tifa Uba52 Tab1 Ubb Ubc Alpk1 Traf6 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling Uba52 Stat1 Ubb Kpnb1 Ubc Kpna1 Ptpn1 Ptpn6 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Ifnb1 Rnasel Ifna4 Socs3 Ifna1 Ifna1l1 Ifna4l1 Rps27a Irf9 Usp18 Tyk2 Ptpn11 Socs1 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 Mbd4 Mpg Smug1 Ogg1 Nthl1 Tdg Apex1 Mutyh Ung ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-RNO-418990.1 Adherens junctions interactions Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Xiap Src Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Cdh8 Vcl Hdac2 Jak2 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Il6 Kmt5a H2ac4 Sec11c Amot Sec11a Il6r Prkcsh Sirt1 Zmym2 Cadm3 Sp1 ENSRNOG00000066901 Cdh24 Cadm2 Cadm1 Rnf19b Pomt1 Hace1 Dnttip1 Pomt2 Stat3 Furin Pcsk7 Pcsk6 Birc2 H2ac18 Adam19 Afdn Ctbp2 Csnk2a2 Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Cdh18 Cdh17 Cdh15 Hist1h2bq Cdh13 Cdh12 Hdac1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 H2aj Canx Tiam1 Arhgap32 Spcs3 Rac1 Spcs1 Spcs2 Psma4 Smarca4 Farp2 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Vav2 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Arhgef4 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%10224241 Hydrolysis of LPC Pla2g4e Pla2g4a Pla2g4d Plbd1 Pla2g15 Pla2g4b Pla2g4f Pla2g4c RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-8868773.1 rRNA processing in the nucleus and cytosol LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Utp18 Wdr43 Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Rpl35al8 Ddx49 Wdr36 Rpl22l1 Rplp0 Ddx47 Rplp1 Rpl13a Rpl35al2 Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Mphosph6 Nol9 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rpl10a Exosc9 Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Rps2 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Csnk1d Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Las1l Rps27 Ltv1 Rpsa Rpl35 Rps10 Fcf1 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rrp9 Rps8 Rpl6 Rps5 Pwp2 Rpl7 Rps26-ps13 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rpl24 Rpl26 Rps3 Imp4 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rpp25 Rps29 Rpl12-ps1 Ubc Rps20 Ncl Rps21 Rpl22 Rps23 Xrn2 Rps24 Rpl23 Snu13 Wdr75 Senp3 Fau Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Pdcd11 Pno1 Rpl27a Rpl31l15 Utp20 Nop14 Pelp1 Rcl1 Utp25 Tbl3 Nol11 Rps6 Rpp40 LOC100910714 LOC102551819 Wdr3 Bud23 Dcaf13 Csnk1e Utp15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-RNO-3000471.1 Scavenging by Class B Receptors Prdx1 Apob Scarb1 Cd36 S100a9 Hmgb1-ps34 Apoa1 Hmgb1l2 Hmgb1l1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Gtf3a Crcp Polr3a Brf2 Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr3f Polr3g Pou2f1 Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%10222485 Neurotransmitter receptors and postsynaptic signal transmission Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Gnai2 Gnai1 Prkca Gnai3 Camk4 Prkar1a Prkar1b Calm3 Nsf Gng3 Gnal Gng5 Gng4 Gng7 Creb1 Gng8 Gngt1 Kcnj9 Gnat3 Kcnj6 Prkar2a Kcnj5 Prkar2b Kcnj4 Cacng4 Kcnj3 Kcnj10 Cacng2 Kcnj2 Gnb2 Gnb1 Gnb4 Kcnj12 Grin2a Gnb3 Gnb5 Lrrc7 Kcnj15 Gria4 Gng11 Kcnj16 Gria3 Camk2g Camk2d Gria2 Camk2b Dlg1 Dlg2 Gria1 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grik2 Grin2d Grik1 Grin2c Grin2b Rps6ka3 Rps6ka1 Rps6ka2 Cacng8 Cacng3 Chrnb4 Chrnb3 Chrnb2 Grip2 Prkcb Epb41l1 Gabrg2 Gabrg3 Grin3a Chrna3 Chrna2 Chrna1 Ap2s1 Chrna7 Grik5 Chrna6 Chrna5 Chrna4 Ap2a2 Grik4 Ap2a1 Chrna9 Grik3 Ap2b1 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabra2 Gabra1 Akap5 Glra3 Glra2 Glra1 Rps6ka6 Tspan7 Camk1 Glrb Ncald Grip1 Chrnd Gabrr1 Chrne Gabrr3 Gabrr2 Chrng Gabrq Gabrb1 Gabrb3 Gabrb2 Htr3b Htr3a Gabbr1 Gabbr2 Arhgef9 Ap2m1 Myo6 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 ESR-MEDIATED SIGNALING%REACTOME%R-RNO-8939211.1 ESR-mediated signaling Ereg Pdpk1 Btc Gnai2 Gnai1 Gnai3 Tle3 Calm3 S1pr3 Creb1 Gnat3 Ptk2 Mapk3 Hbegf Src Nras Kras Polr2c Hras Polr2a Tgfa Polr2b Polr2g Atf2 Polr2h Areg Polr2e Polr2f Polr2i Polr2j Kat5 Gtf2f2 Gtf2f1 Fos Egfr Hsp90ab1 H2ab2 Jun H2ac4 Kdm4b Gata3 ENSRNOG00000066901 Ppp5c Cbfb Esr1 Crebbp H2ac18 Egf Hist1h2bq Prmt1 Hdac1 Pik3ca H2aj Shc1 Cav1 Akt3 Tbp H3-3b Akt2 Akt1 Hist3h2ba Gtf2a1 Pik3r1 Ep300 Nrip1 Gtf2a2 Hsp90aa1 ENSRNOG00000068602 Pik3r2 Pik3r3 Ppid Uhmk1 H2bc18 Ppidl1 Runx1 Kat2b H2az2 H2bc4 Kdm1a Hist1h4m H2bc1 Sphk1 Hist1h2ai Zdhhc7 Pgr Xpo1 Greb1 Cited1 Strn Prkcz Cav2 Esr2 Cdk9 Igf1r Pou2f1 Foxo3 Mmp7 Mmp2 Mmp3 Cdkn1b Zdhhc21 Fkbp4 Mmp9 Fkbp5 Ptges3 Carm1 Zfp217 Foxa1 Ncoa3 Mapk1 Nos3 Yy1 Nr5a2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%10222221 Signaling by Insulin receptor Ins2 Pdpk1 Frs2 Atp6v0b Trib3 Atp6v0a4 Grb10 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Fgfr3 Atp6v1c1 Fgfr4 Atp6v0c Fgfr1 Ptprf Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Atp6ap1 Pik3ca Fgf18 Shc1 Insr Atp6v1e2 Fgf19 Atp6v1e1 Tcirg1 Gab2 Atp6v1a Atp6v1b2 Fgf10 Atp6v0d2 Ide Mapk3 Akt2 Atp6v0d1 Atp6v1b1 Pik3r1 Atp6v0e1 Pik3cb Atp6v1g2 Atp6v1g1 Atp6v1f Pik3r2 Grb2 Atp6v1d Sos1 Ptpn11 Fgf20 Fgf23 Fgf22 Pik3c3 Gab1 Irs2 Pik3r4 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Ptpn1 Mapk1 Ctsd Kl Flt3 Ins1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Hfe Tf Steap3 Steap4 Mcoln1 Tfrc Tfr2 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 96%10224861 Cargo concentration in the ER Lman1 Lman2 Serpina1 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Preb Tmed2 Folr1 Cd59 Sec23a Lman2l Cnih1 Cnih3 Cnih2 Ctsc Mia2 Mia3 Sar1b Tmed10 Col7a1 Tgfa Areg Gria1 F8 Ctsz Gosr2 Lman1l LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223825 Lysosome Vesicle Biogenesis Ap1m2 Vamp7 Bloc1s1 Ap1m1 Vamp8 Ap4s1 Ap1s3 Arrb1 Ap1s2 Txndc5 Ap1g2 Ap1g1 Ap4m1 Hspa8 Ap4e1 M6pr Dnm2 Clta Cltb Hgs Cltc Arf1 Gns Vamp2 App Dnajc6 Sh3gl2 Clvs1 Dnase2 Clvs2 Ctsz Ap4b1 Ap1b1 Chmp2a APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%10224747 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Neil1 Polb Ogg1 Xrcc1 Neil2 Lig3 Pnkp CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223775 Cation-coupled Chloride cotransporters Slc12a1 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223791 Type II Na+ Pi cotransporters Slc34a1 Slc34a3 Slc34a2 HS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022928.1 HS-GAG biosynthesis Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Gpc6 Sdc1 Hs3st4 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Ext2 Ext1 Slc35d2 Sdc4 Sdc3 Sdc2 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224411 Ubiquinol biosynthesis Pdss2 Coq8a Pdss1 Coq8b Coq2 Coq3 Coq4 Coq5 Coq6 Hpdl Coq7 Coq9 Stard7 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis Hmgcr Mvd Msmo1 Srebf1 Fdps Plpp6 Idi1 Hsd17b7 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Lbr Acat2 Nsdhl Dhcr24 Dhcr7 Lss Tm7sf2 Srebf2 Pmvk RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10224733 RHO GTPases regulate CFTR trafficking Gopc Rhoq Cftr NGF PROCESSING%REACTOME%R-RNO-167060.1 NGF processing Furin Pcsk5 Ngf Pcsk6 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-RNO-983169.1 Class I MHC mediated antigen processing & presentation Mib2 Ube2d3 Ube2d2 Cd207 Mrc2 Mrc1 Prkn Stub1 Sar1b Ube2l3 Kbtbd7 Smurf2 Ube2n Cd36 Fbxw11 Cbll1 Ube2j2 Itgav Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Vamp8 Psmb2 Uba52 Anapc10 Ube2d1 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdc16 Rnf123 Siah2 Keap1 Lrr1 Nedd4 Rnf220 Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb RT1-M6-2 Vamp3 Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 B2m Dcaf1 Rnf126 Ubac1 Lnpep Sec23a Atg7 Rnf114 Rnf115 Rnf111 RT1-M10-ps1 RT1-M10-ps5 Snap23 Siah1 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 RT1-N3 Rnf130 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Sec31a Klhl2 Ube4a Spsb2 RT1-M1-2 Trim9 Spsb1 Trip12 Wwp1 RT1-M1-5 Spsb4 Calr Rt1-ec3 Lrsam1 Eloc Huwe1 Elob Ube2j1 Sec24d Kctd7 Sec24c Ube2u Sec24b Kctd6 Sec24a Ncf1 Ncf2 Ube2w Ncf4 Ube2m Ube2k Rnf182 Ube2o Ltn1 Pdia3 Ube2v2 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Herc2 Socs1 Trim71 Klhl25 Rnf19b Ube2e3 Ube2e2 Klhl21 Btbd6 Hace1 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Psme2 Fbxl7 Psme1 Lonrf1 Psmb9 Zbtb16 Psmb10 Hspa5 Psmb8 Uba1 Cyba Cybb Uba3 Cul2 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Canx Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Itch Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Rchy1 Asb1 Lnx1 Fcgr1a Sec13 Rbx1 Socs3 Smurf1 Cul3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%10222811 Creation of C4 and C2 activators Fcn2 Fcn1 Mbl2 Masp1 Masp2 C1qb Crp C1qa Colec10 C1s C1r C1qc ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%10222927 p38MAPK events Ralgds Kras Mapkapk3 Hras Mapk14 Mapkapk2 Mapk11 Nras ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%10224233 Acyl chain remodelling of PG Pla2g4f Pla2g2d Pla2g2f Pla2g2a Pla2g1b Pla2g4a Pla2g4d Pla2r1 Pla2g12a Pla2g4b Lpcat4 Pla2g10 Lpgat1 Lpcat1 Pla2g5 Pla2g3 Crls1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%10222057 Neurotransmitter uptake and metabolism In glial cells Glul Slc38a1 Slc1a3 Slc1a2 RHOT2 GTPASE CYCLE%REACTOME%R-RNO-9013419.1 RHOT2 GTPase cycle Rhot2 Mfn1 Mfn2 Trak1 Myo19 Trak2 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224697 DAG1 core M3 glycosylations Pomgnt2 Pomt1 Pomt2 Dag1 B3galnt2 Pomk GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism Aldoa Nup133 Pfkl Nup210 Nup155 Pgk2 Nup153 Pck1 Pfkm Pfkp Pck2 Pgm2l1 G6pc1 Pkml1 Gck Hk2 Hk3 Adpgk G6pc3 Tpi1l2 Aldob Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Gnpda1 Gpi Nup205 Gnpda2 Nup107 Eno3 Sec13 Eno2 Eno4 Nup188 Pfkfb4 Tpr Pfkfb3 Pfkfb2 Nup160 Pgk1 Pfkfb1 Rae1 Pc Pgam2 Ndc1 Pgam1 Slc37a4 Tpi1 Nup85 Slc37a2 Nup42 Slc37a1 Nup62 Hkdc1 Nup43 Nup88 Fbp1 Fbp2 Gckr Aaas Pklr Ranbp2 Gapdhs Aldoc Nup214 Bpgm LANOSTEROL BIOSYNTHESIS%REACTOME%R-RNO-9969896.1 Lanosterol biosynthesis Hmgcr Mvd Fdps Plpp6 Idi1 Mvk Fdft1 Sqle Hmgcs1 Ggps1 Acat2 Lss Pmvk ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%10224485 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nek9 Ccnb1 Plk1 Ccnb2-ps2 Ccnb2 Cdk1 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 96%10225447 Mitochondrial unfolded protein response (UPRmt) Hsf1 Dnaja1 Hspa1b Sirt3 Hspa1a Esr1 Akt1 Foxo3 SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog Adcy5 Adcy6 Gsk3b Adcy9 Os9 Prkaca Prkacb Sel1l Prkar1a Prkar1b Rpgrip1l Tulp3 Adcy10 Ift140 Grk2 Disp2 Scube2 Kif3a Fuz Hhat Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Intu Prkar2a Wdr35 Prkar2b Dync2h1 Ift172 Wdr19 Notum Syvn1 Cdc73 P4hb Smurf2 Gpc5 Numb Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Dzip1 Psmd6 Gpr161 Psmd8 Ihh Gli1 Psmd2 Gli3 Derl2 Gli2 Psmd1 Shh Adrm1 Rbx1 Cul1 Kif7 Evc Smo Spop Ulk3 Vcp Smurf1 Cdon Dhh Spopl Ptch1 Evc2 Hhip Sufu Adcy3 Adcy4 Adcy1 Cul3 Adcy2 Erlec1 Adcy7 Adcy8 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 96%10224001 Regulation of signaling by CBL Pik3ca Syk Lyn Yes1 Crkl Rapgef1 Pik3r1 Pik3cb Cbl Hck Grb2 Pik3r2 Fyn Pik3r3 Vav1 Pik3cd Crk NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling Ntrk3 Ntf3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA Cpsf7 Cpsf1 Ncbp2 Cpsf2 Ncbp1 Cpsf3 Snrpepl2 Snrpf Slbp Snrpg Snrpb Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Cstf2 Cstf3 Cstf2t Lsm10 Lsm11 Sympk Pabpn1 Snrpd3 Clp1 Cpsf4 Cpsf6 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%10224669 Regulation of TLR by endogenous ligand Fgb Fga S100a1 Fgg Gsdme Tlr1 Gsdmd Tlr7 Cd36 Tlr6 S100a9 Lbp S100a8 Tlr2 Hmgb1l2 Hmgb1l1 Apob Ly96 Hmgb1-ps34 Cd14 Tlr4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%10223029 Downstream signaling of activated FGFR2 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Fgfr2 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Fgf10 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Fgf22 Gab1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Pold2 Pold1 Rpa1 Rpa2 Rpa3 Pold4 Lig1 Pold3 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 96%10222629 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Ppp2r5b Dync1h1 Ppp2r5a Spc24 Spc25 Xpo1 Nuf2 Mad2l1 Cdca8 Incenp Dync1i2 Bub1b Ndel1 Ppp1cc Dync1i1 Cenpc Cenpa Aurkb B9d2 Ppp2r5e Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225131 RHOA GTPase cycle Lman1 Scfd1 Hmox2 Vamp3 Snap23 Acbd5 Flot2 Flot1 Rhoa Ngef Abcd3 Srgap1 Arhgap45 Stx5 Slk Ykt6 Cavin1 Daam1 Pgrmc2 Tex2 Bcr Arhgap6 Jup Arhgap5 Arhgap4 Sowahc Arhgap1 Stom Arap1 Arap3 Arap2 Arhgap9 Arhgap8 Mcam Pld1 Ccdc115 Rtkn Rhpn1 Rhpn2 Stk10 Stard8 Maco1 Ddrgk1 Faf2 Arhgdib Gmip Anln Arhgap10 Iqgap3 Diaph3 Diaph1 Arhgap19 Rasgrf2 Arhgap18 Depdc1b Cit Fam13a Arhgef28 C1qbp Arhgap22 Arhgap21 Arhgap20 Arhgap26 Arhgap24 Arhgap23 Arhgap29 Arhgap28 Ophn1 Stbd1 Dock2 Def6 Vapb Pcdh7 Myo9b Emc3 Arhgap11a Myo9a Arhgap31 Arhgap30 Prex2 Actc1 Arhgap35 Fmnl3 Tagap Racgap1 Plekhg6 Tmem87a Plekhg3 Bcap31 Ktn1 Farp1 Dlc1 Stard13 Arhgap40 Pkn2 Arhgef7 Rock2 Rock1 Pkn1 Arhgap44 Arhgap42 Tjp2 Atp6ap1 Tiam1 Arhgap32 Mcf2l Cav1 Arhgef15 Arhgef17 Arhgef11 Pik3r1 Arhgef10 Arhgef12 Arhgef19 Vav3 Pik3r2 Akap13 Vav1 Vav2 Tfrc Arhgef25 Kalrn Arhgef5 Arhgef4 Arhgef2 Arhgef1 Obscn Abr Ect2 Prex1 Trio Plekhg5 Net1 Arhgef10l Lbr Aaas Mcf2 Arhgdia PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis Stard4 Tspoap1 Star Stard6 Cyp11a1 Tspo Fdx2 Fdxr Fdx1 Akr1b1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%10222167 RNA Polymerase I Promoter Clearance Cdk7 Rbbp4 Rbbp7 H2ac18 Mnat1 Hist1h2bq Hdac1 H2aj Tbp Polr1b H3-3b Mapk3 Polr1a Polr1f Hist3h2ba Polr1g Polr1e Polr1h ENSRNOG00000068602 Chd3 Chd4 Taf1d Rrn3 Mbd2 Taf1a Taf1c Taf1b Mta1 H2bc18 Mta2 Polr2h Mta3 Mbd3 H2az2 Polr2e Cbx3 Polr2f H2bc4 Ercc6 Hist1h4m Ubtf H2bc1 Gatad2a Gatad2b Hist1h2ai Gtf2h2 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Ttf1 Polr1c Hdac2 H2ab2 Ccnh H2ac4 ENSRNOG00000066901 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes Ppp2cb Ppp2ca Stat3 Furin Stat1 Nedd4 Plcg1 Hspa1b Ube2l6 Hspa1a Actg1 Ppp2r1b Ppp2r1a Mapk3 Rnasel Ikbkb Sfn Dnajc3 Eif2ak2 Ikbkg Sphk1 Ppp2r5a Fancl Fancm Ube2n Pim1 Fanca Fancb Fancc Mapt Fance Fancf Fancg Nck1 Hspa8 Gbp5 Pde12 Prkra Ilf2 Actb Dus2 Ilf3 Flnb Tarbp2 Snca Dhx9 Ppm1b Mx2 Arih1 Pggt1b Trim25 Ptpn2 Map2k6 Hspa1l Gbp2 Tp53 Gbp1 Ube2e1 Gbp3 Faap100 Npm1 Casp1 Oasl Hspa2 Faap24 Isg15 Faap20 Irf3 Mavs Rig1 Cdk1 Becn1 Adar Fnta Usp18 Fntb Chuk Uba7 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%10224985 Synaptic adhesion-like molecules Grin1 Grin2d Grin2c Grin2b Lrfn2 Rtn3 Flot2 Lrfn3 Flot1 Lrfn4 Lrfn1 Ptprs Grin2a Gria4 Gria3 Dlg1 Gria1 Dlg3 Dlg4 Ptprf APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Rps14 Rps15 Rps16 Eif2s3 Rps17 Rpl4 Rps15a Rpl5 Rps18 Eif2s2 Rpl3 Rps19 Rps27 Pabpc1 Eif2s1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Eif4h Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Eif4a2 Eif4a1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 Eif4e OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cul2 Ube2d3 Ube2d2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Vhl Psmb1 Psmb3 Psmb2 Uba52 Eloc Ube2d1 Elob Psma7 Ajuba Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Egln1 Egln2 Egln3 Epas1 Hif3a Wtip Limd1 Hif1a PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism Itpa Pnp Dnph1 Nudt5 Xdh Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224205 GRB7 events in ERBB2 signaling Grb7 Erbb2 Erbb3 Nrg2 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224361 DS-GAG biosynthesis Bcan Vcan Dsel Ust Dse Ncan Cspg5 Bgn Dcn Cspg4 Chst14 Chst15 CS DS DEGRADATION%REACTOME%R-RNO-2024101.1 CS DS degradation Bcan Vcan Ncan Cspg5 Bgn Dcn Cspg4 Idua Hyal4 Hyal3 Glb1l Ids Hyal1 Gusb Glb1l3 Glb1l2 Glb1 Arsb Hexa Hexb STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 96%10223159 Sterols are 12-hydroxylated by CYP8B1 Cyp8b1 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%10224519 SUMOylation of nuclear envelope proteins Rangap1 Ube2i Sumo1 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 96%10224907 TP53 Regulates Transcription of Death Receptors and Ligands Igfbp3 Tmem219 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224779 FGFRL1 modulation of FGFR1 signaling Fgf17 Fgf18 Spred1 Fgf10 Spred2 Fgfrl1 Fgf2 Fgf4 Fgf23 Fgf3 Fgf5 Fgf22 Fgf8 FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling Casp8 Fas Fadd Faslg HDL REMODELING%REACTOME DATABASE ID RELEASE 96%10223449 HDL remodeling Apoe Lipg Pltp Lcat Alb Apoc2 Apoa1 Apoc3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223717 Trafficking of AMPA receptors Tspan7 Grip1 Prkcg Prkca Nsf Ap2m1 Myo6 Cacng8 Cacng3 Grip2 Cacng4 Prkcb Epb41l1 Cacng2 Ap2s1 Gria4 Gria3 Camk2g Camk2d Ap2a2 Gria2 Ap2a1 Camk2b Ap2b1 Pick1 Dlg1 Gria1 Dlg4 Camk2a Akap5 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-194313.1 VEGF ligand-receptor interactions Flt1 Flt4 Vegfa Kdr Vegfd Vegfc Pgf Vegfb INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Il1b Psma4 Il1r2 Il1r1 Psma3 Sqstm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Nkiras1 Psmd13 App Ikbkb Skp1 Nkiras2 Psmb5 Psmb4 Traf6 Psmb7 Peli1 Psmb6 Ikbkg Map3k8 Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Fbxw11 Btrc Psma7 Alpk1 Rela Psmc5 Peli2 Psmc2 Psmc1 Peli3 Psmc4 Tifa Psmc3 Tnip2 S100b Myd88 Map2k6 Ubb Hmgb1-ps34 Ubc N4bp1 Psmb6l1 Psmd7 Casp8 Nfkbib Psmd6 Psmd8 Psmd2 Irak2 Psmd1 Irak1 Adrm1 Rbx1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%10225033 TFAP2 (AP-2) family regulates transcription of cell cycle factors Tfap2c Myc Kdm5b NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223523 Neurofascin interactions Ank1 Sdcbp Nfasc CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%10224457 Condensation of Prometaphase Chromosomes Smc2 Csnk2b Csnk2a2 Csnk2a1 Ncapd2 Ncapg Smc4 Ncaph REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-RNO-350562.1 Regulation of ornithine decarboxylase (ODC) Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Odc1 Oaz1 Psmd12 Oaz3 Psmd11 Oaz2 Psmd14 Nqo1 Psmd13 Azin1 Psmb5 Psmb4 Psmb7 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222599 Activation of BMF and translocation to mitochondria Dynll2 Bmf Mapk8 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224075 Termination of O-glycan biosynthesis St6galnac3 St6galnac2 St3gal4 St3gal2 St3gal3 St3gal1 Muc15 Muc13 St6gal1 Muc19 Muc5b Muc4 Muc6 RHOV GTPASE CYCLE%REACTOME%R-RNO-9013424.1 RHOV GTPase cycle Wdr6 Txnl1 Pak6 Rhov Ccp110 Pak4 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Myo9a Nck1 Dst Sh3rf1 Map3k11 Arhgef7 Cltc Nck2 Pak1 Git1 Sptbn1 Pak2 Pard6b Tpm4 Pard6a Sptan1 Pik3r1 Depdc1b Cdc42 Usp9x Peak1 Cep97 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-RNO-1247673.1 Erythrocytes take up oxygen and release carbon dioxide Slc4a1 Aqp1 Ca1 Ca2 Ca4 Hba1 Hbb Rhag METABOLISM OF RNA%REACTOME%R-RNO-8953854.1 Metabolism of RNA Sde2 LOC120093247 Heatr1 Slu7 Nob1 Srrm2 Dcps Utp11 Zfp36l1 Ddx52 Nkap Rpl36a Hnrnph2 Utp18 Wdr43 Hnrnph1 Rrp7a Prpf6 Noc4l Khsrp Dis3 Zmat5 Rplp2 Ppig Tex10 Ppie Riok1 Rbmx2 Riok2 Cwc22 AABR07072440.1 Cwc27 Gnl3 Cwc25 Rpl35al8 Prpf8 Wbp11 Ddx49 Wdr36 Papolg Rpl22l1 Ppp1r8 Rplp0 Snip1 Cwc15 Ddx47 Rplp1 Nt5c3b Pan2 Rpl13a Rpl35al2 Pan3 Rpl18a Rbm25l1 Nip7 Gpatch1 Rpl13 Magohb Rpl14 Ddx6 Rrp36 Pqbp1 Rpl15 Qng1 Prr3 Mphosph6 Nol9 Ybx1 Rpl17 Dnajc8 Rbm26 Rpp14 Rpl18 Rbm25 Rpl19 Rbm27 Nol6 Rbm7 Utp14a Rbm5 Mphosph10 Rbm22 Rpl10 Rbm17 Pes1 Ddx46 Rpl11 Bud31 Ddx41 Bms1 C1d Ddx42 Rpl12 Wtap Cwf19l2 Rpl10a Exosc9 Poldip3 Exosc8 Tnfsf13 Exosc5 Nxf5 Krr1 Rbmx Exosc4 Nxf7 Exosc7 Tra2b Exosc6 Acin1 Exosc1 Bud13 Utp3 Ddx23 Exosc3 Utp4 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Ppp1cb Mapkapk2 Ywhab Akt1 Ppp2r2a Hspa8 Rps6 Eif4e Rps2 Rps27 Yrdc Wdr82 Xpo1 Rbbp6 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 Snrpg Gemin5 Snrpb Nup58 Gemin8 Nup37 Pom121 Prmt5 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Smn1 Nup160 Rae1 Snupn Ndc1 Snrpd1 Clns1a Nup85 Nup42 Nup62 Nup43 Nup88 Gemin7l1 Aaas Snrpd3 Ranbp2 Csnk1e Nup214 Gemin2 Ywhaz Nup133 Nup210 Nup155 Nup153 Ddx20 Snrpepl2 Wdr77 Hspa1b Hspa1a Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Polr2c Cstf2 Polr2a Cstf3 Polr2b Cstf2t Polr2g Lsm10 Polr2h Lsm11 Sympk Polr2e Pabpn1 Polr2f Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Alyref Nxf1 Slbp Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Rps14 Psmd13 Rps15 Rps16 Rps17 Rps15a Rps18 Rps19 Pabpc1 Psmb5 Rpsa Psmb4 Rps10 Psmb7 Rps11 Psmb6 Rps13 Rps4x-ps13 Psmb1 Rps3a Psmb3 Rps27l Psmb2 Rps9 Uba52 Rps7 Rps8 Rps5 Rps26-ps13 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Dhx9 Rps3 Rps25 Rps4x Rps26 Rps28 Ubb Rps29 Rps20 Ubc Rps21 Rps23 Psmb6l1 Rps24 Eif4a2 Psmd7 Eif4a1 Psmd6 Fau Psmd8 Psmd2 Psmd1 Adrm1 Ppp1ca Ppp2ca Prkcd Prkca Ppp2r1a Csnk1d Snrnp200 Phf5a Fam50a Gle1 Znf830 Fyttd1 Anp32a Hnrnpr-ps2 Rnf113a1 U2surp Crnkl1 Rnf113a2 Skic3 Skic2 Skic8 Parn Upf3b Sarnp Upf3a Set Wdr70 Snrpa1 Mettl3 Steep1 C3h9orf78 Ptbp1 A1cf Ccnh Eif4a3 Rnpc3 Ppwd1 Smg1 Smg9 Smg8 Adarb1 Smg7 Adar Gcfc2 Smg6 Smg5 Ccdc12 Paip1 Upf1 Upf2 Rbm8a Tut1 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Cdk7 Edc3 Edc4 Zcchc8 Thoc2 Zfc3h1 Thoc3 Hnrnpa2b1 Thoc5 Thoc6 Thoc7 Zfp36 Rnmt Srrt Mnat1 Snrnp70 Nsrp1 Zcrb1 Prpf19 Htatsf1 Snrnp40 Prpf18 Eftud2 Snrnp48 Fam32a Snrpa Snrpc Snrpn Chtop Zc3h18 Cherp Yju2 Fus Lsm3 Lsm5 Lsm1 Lsm6 Zc3h4 Lsm7 Zc3h3 Casc3 Isy1 Nxt1 Cdc5l Snrnp25 Ythdc2 Ythdc1 Srsf1 Plrg1 Rpl4 Patl1 Rpl5 Srsf9 Rpl3 Srsf7 Las1l Srsf5 Srsf3 Ltv1 Rpl35 Srsf2 Snrnp35 Fcf1 Rpl36 Hnrnpa3 Rpl37 Syf2 Rpl38 Etf1 Rpl39 Puf60 Rpl8 U2af1 Rpl9 Ppil4 Rrp9 Ppil3 Rpl6 Hnrnpa1 Ppil2 Pwp2 Rpl7 Ppil1 Sap18 Rpp38 Bysl Pnrc2 U2af1l4 Fbl Rpl30 Tcerg1 LOC134486107 Tnpo1 Rpl31 Bcas2 Rpl32 Pdcd7 Gpkow Rpp30 Rpl34 Rngtt Rpl36al1 Rnps1 Ftsj3 Smndc1 Pnn Rpl39l1 Rpl24 Prpf40a Rpl26 Cdc40 Ddx39a Imp4 Rpl27 Aqr Rpl28 Prcc Rpl29 Pcbp2 Pcbp1 Rpp25 Rpl12-ps1 Magoh Ncl Ddx39b Rpl22 Dcp1a Dcp1b Xrn2 Rpl23 Xrn1 Snu13 Gspt2 Wdr75 Tfip11 Senp3 Gspt1 Dhx8 Isg20l2 Exosc10 Hnrnpr Hnrnpu Emg1 Rbm10 Eri1 Dhx38 LOC120097744 Dhx37 Dhx35 Elavl1 Rpl36l5 Mettl14 Rpl36l3 Rpl3l Apobec4 Pdcd11 Apobec2 Pno1 Apobec3 Rpl27a Sugp1 Rpl31l15 Apobec1 Zrsr2 Utp20 Nop14 Hnrnpc Pelp1 Hnrnpd Hnrnpf Rcl1 Hnrnpk Hspb1 Utp25 Tbl3 Hnrnpl Nol11 Dcp2 Hbs1l Rpp40 LOC100910714 Dhx16 LOC102551819 Dhx15 Wdr3 Srsf19 Srsf11 Bud23 Srsf12 Dcaf13 Srrm1 Utp15 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-RNO-9959399.1 SLC-mediated transport of oligopeptides Slc15a1 Ctns Slc15a3 Slc15a4 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-RNO-5626467.1 RHO GTPases activate IQGAPs Cdh1 Ctnna1 Men1 Clip1 Calm3 Rac1 Ctnnb1 Cdc42 Iqgap2 Iqgap3 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine Amdhd2 Uap1 Gfpt1 Gfpt2 Pgm3 Renbp Nagk Gnpnat1 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion Apobec1 A1cf Apobec4 Apobec2 Apobec3 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%10222349 Beta oxidation of octanoyl-CoA to hexanoyl-CoA Acadm Hadha Hadhb Echs1 Hadh MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%10222251 mRNA Splicing Sde2 Slu7 Srrm2 Snrpepl2 Nkap Hnrnph2 Hnrnph1 Prpf6 Zmat5 Ppig Ppie Rbmx2 Cwc22 Cwc27 Cwc25 Prpf8 Wbp11 Snip1 Cwc15 Gpatch1 Magohb Pqbp1 Ybx1 Rbm22 Rbm17 Ddx46 Bud31 Ddx41 Ddx42 Cwf19l2 Rbmx Polr2c Tra2b Polr2a Acin1 Polr2b Bud13 Polr2g Ddx23 Polr2h Polr2e Polr2f Polr2i Polr2j Ncbp2 Ncbp1 Gtf2f2 Gtf2f1 Snrnp200 Phf5a Fam50a Znf830 Hnrnpr-ps2 Alyref Rnf113a1 U2surp Crnkl1 Rnf113a2 Upf3b Wdr70 Snrpa1 Steep1 C3h9orf78 Ptbp1 Eif4a3 Rnpc3 Ppwd1 Gcfc2 Ccdc12 Rbm8a Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Hnrnpa2b1 Srrt Nsrp1 Zcrb1 Prpf19 Snrnp40 Prpf18 Eftud2 Snrnp48 Fam32a Snrpn Cherp Yju2 Fus Casc3 Isy1 Cdc5l Snrnp25 Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Snrnp35 Hnrnpa3 Syf2 Puf60 Ppil4 Ppil3 Hnrnpa1 Ppil2 Ppil1 Sap18 Hspa8 Bcas2 Pdcd7 Gpkow Rnps1 Smndc1 Pnn Cdc40 Aqr Prcc Pcbp2 Snrpf Pcbp1 Magoh Ddx39b Snrpg Snrpb Tfip11 Dhx8 Hnrnpr Hnrnpu Rbm10 Dhx38 Dhx35 Zrsr2 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx16 Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 Srrm1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-RNO-9609523.1 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Serp1 Sgta Stx1a Hmox1 Aldh3a2 Sec61gl4 Vapa Stx5 Emd Vamp2 App Cyb5a Ube2j2 Prnp RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%10222237 RNA Polymerase I Transcription Termination Gtf2h2 Gtf2h1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Cavin1 Ttf1 Polr1c Mnat1 Tbp Polr1b Polr1a Ccnh Polr1f Polr1g Polr1e Polr1h Taf1d Taf1a Taf1c Taf1b Polr2h Polr2e Polr2f Ubtf REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs Rasal3 Syngap1 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Psma4 Psma3 Psma6 Psma5 Psma2 Nras Psma1 Rps27a Psmd12 Psmd11 Kras Psmd14 Hras Psmd13 Kbtbd7 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Dab2ip Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Nf1 Cul3 Rasal1 Rasal2 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-RNO-191650.1 Regulation of gap junction activity Tjp1 Src Gja1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-RNO-5357956.1 TNFR1-induced NF-kappa-B signaling pathway Ikbkg Map3k7 Traf2 Sharpin Tnf Otud1 Tnfrsf1a Birc2 Traf1 Spata2 Rnf31 Rack1 Usp2 Xiap Usp4 Tradd Cyld Optn Ripk1 Tab3 Otud7b Tab2 Tab1 Rbck1 Chuk Ikbkb Usp21 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Cyp8b1 Akr1c18 Ptges3 Akr1c12l1 Akr1c19 Akr1c21 Cbr1 Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Akr1c3l1 Ptgs2 Akr1c12 Hpgds Akr1c1 Akr1c13 Akr1c9 CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Cdk11b Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Tubg2 Clasp1 Tubg1 Ywhae Cep63 Nme7 Cep152 Tuba4a Plk1 Tubgcp2 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Tubgcp6 Cdk1 Tubgcp5 Tubgcp4 Tubgcp3 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Mzt1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins Fgb Apbb1ip Fga Bcar1 Fgg Itga2b Ptk2 Src Tln1 Rap1a Rap1b Fn1 Itgb3 Crk PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 96%10224437 Phosphate bond hydrolysis by NUDT proteins Nudt5 Nudt9 Nudt16 Nudt18 Adprm Nudt1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-RNO-187577.1 SCF(Skp2)-mediated degradation of p27 p21 Psmb6 Psmb1 Ccnd1 Psmb3 Psmb2 Uba52 Cks1b Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Ccna1 Psmd1 Psma3 Adrm1 Ccna2 Cul1 Cdk2 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Skp2 Cdk4 Skp1 Psmb5 Psmb4 Ptk6 Psmb7 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 96%10225453 Signaling by LTK Grb2 Pik3r2 Pik3ca Shc1 Sos1 Irs1 Ltk Tnk2 Alkal2 Alkal1 Pik3r1 Pik3cb PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA Sde2 Nup133 Nup210 Slu7 Srrm2 Nup155 Nup153 Nkap Snrpepl2 Hnrnph2 Hnrnph1 Prpf6 Zmat5 Ppig Ppie Rbmx2 Cwc22 Cwc27 Cwc25 Prpf8 Wbp11 Papolg Ppp1r8 Snip1 Cwc15 Rbm25l1 Gpatch1 Magohb Pqbp1 Prr3 Ybx1 Dnajc8 Rbm25 Rbm5 Rbm22 Rbm17 Ddx46 Bud31 Ddx41 Ddx42 Wtap Cwf19l2 Pcf11 Poldip3 Fip1l1 Cstf1 Nxf5 Rbmx Papola Nxf7 Nudt21 Polr2c Tra2b Cstf2 Polr2a Acin1 Cstf3 Polr2b Bud13 Polr2g Cstf2t Ddx23 Polr2h Sympk Polr2e Polr2f Pabpn1 Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2f2 Gtf2f1 Ppp1cb Alyref Nxf1 Slbp Rps27a Uba52 Hspa8 Dhx9 Ubb Ubc Eif4e Ppp1ca Snrnp200 Phf5a Fam50a Gle1 Znf830 Fyttd1 Hnrnpr-ps2 Rnf113a1 U2surp Crnkl1 Rnf113a2 Upf3b Sarnp Wdr70 Snrpa1 Mettl3 Steep1 C3h9orf78 Ptbp1 Eif4a3 Rnpc3 Ppwd1 Gcfc2 Ccdc12 Rbm8a Tut1 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Thoc2 Thoc3 Hnrnpa2b1 Thoc5 Thoc6 Thoc7 Srrt Snrnp70 Nsrp1 Zcrb1 Prpf19 Htatsf1 Snrnp40 Prpf18 Eftud2 Snrnp48 Fam32a Snrpa Snrpc Snrpn Chtop Cherp Yju2 Fus Casc3 Isy1 Nxt1 Cdc5l Snrnp25 Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Snrnp35 Hnrnpa3 Syf2 Puf60 U2af1 Ppil4 Ppil3 Hnrnpa1 Ppil2 Rbbp6 Ppil1 Sap18 U2af1l4 Tcerg1 Bcas2 Pdcd7 Gpkow Rnps1 Smndc1 Pnn Prpf40a Cdc40 Ddx39a Nup93 Aqr Nup50 Prcc Pcbp2 Snrpf Pcbp1 Magoh Nup35 Ddx39b Nup54 Nup98 Snrpg Snrpb Tfip11 Nup58 Dhx8 Nup37 Hnrnpr Pom121 Hnrnpu Nup205 Rbm10 Nup107 Dhx38 Dhx35 Sec13 Mettl14 Nup188 Tpr Nup160 Sugp1 Rae1 Zrsr2 Ndc1 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Nup85 Hnrnpk Nup42 Hnrnpl Nup62 Nup43 Nup88 Dhx16 Aaas Dhx15 Srsf19 Snrpd3 Ranbp2 Srsf11 Nup214 Srsf12 Srrm1 VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly P4hb Apob Mttp Apoc1 Apoc4 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10223353 NOSIP mediated eNOS trafficking Nos3 Nosip ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%10221921 Activation of the pre-replicative complex Cdc6 Mcm7 Mcm8 Dbf4 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Pole Pola2 Cdk2 Pola1 Prim2 Prim1 Orc4 Orc6 Orc1 Orc3 Orc2 Cdt1 Gmnn Cdc7 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 96%10224895 TP53 Regulates Transcription of DNA Repair Genes Polr2j Ctdp1 Gtf2h2 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Nelfcd Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Cdk9 Ssrp1 Eloa2l Mnat1 Eloa Ccnh Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%10224085 Factors involved in megakaryocyte development and platelet production Dock2 Prkaca Prkacb Racgap1 Prkar1a Prkar1b Kif18b Kif19 Kif26b Kifc1 Kifc2 Kif3a Kif26a Hdac1 Rbsn Rcor1 Jmjd1c Kif11 Kif12 Akap1 Kif15 Akap10 Prkar2a Rac1 Kif5a Prkar2b Kif5b Kif21a Kif1c Ak3 H3-3b Kif21b Kif13b Kif1a Kif1b Kif6 Zfpm2 Dock5 Dock6 Kif9 Dock3 Dock4 Dock7 Dock8 H2bc18 Gata5 Kif22 Kif23 Gata4 Kif28 Kdm1a Kif27 Kif16b Kif18a Kif20a Klc1 Kif20b Hmg20b Kifap3 Itpk1 Maff Klc4 Rab5a Mafg Klc3 Klc2 Nfe2 Cbx5 Kif3b Dock10 Dock11 Kif3c Vps45 Rad51c Sh2b2 Sh2b1 Rad51b Ehd1 Ehd2 Ehd3 Gata6 Cenpe Mfn1 Hdac2 Jak2 Mfn2 Kif2a Kif2b Kif2c Kif4b Zfpm1 Kif4a Gata3 Gata1 Gata2 Cdc42 HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%10222561 Hemostasis Prkcq Rasgrp1 Tln1 Fn1 Pdgfa Pdgfb Prkg2 Ptk2 Mapk3 Nras Grb2 Fyn Rap1a Kras Sos1 Rap1b Hras App Ppp2r5b Ppp2r5a Apbb1ip Cd36 Ppp2r5e Nos2 Hgf Hdac2 Vcl Tuba4a Mapk14 Prkcb Kif4b Kif4a L1cam Lat Itgav Tgfb1 Angpt1 Tgfb2 Tgfb3 Fgb Fga Fgg Itga2b Csk Egf Itgb1 Tek Serping1 Kif18b Itgb3 Kif19 Clu Kif26b Kifc1 Kifc2 Kif26a Rbsn Rcor1 Jmjd1c Kif11 Kif12 Akap1 Kif15 Akap10 Kif5a Kif5b Kif21a Kif1c Ak3 Kif21b Akt1 Kif13b Kif1a Kif1b Kif6 Zfpm2 Dock5 Dock6 Tf Kif9 Dock3 Dock4 Dock7 Dock8 Gata5 Kif22 Kif23 Gata4 Kif28 Kif27 Kif16b Kif20a Klc1 Kif20b Hmg20b Kifap3 Itpk1 Maff Klc4 Rab5a Mafg Klc3 Klc2 Nfe2 Cbx5 Kif3b Dock10 Dock11 Kif3c Vps45 Sh2b2 Sh2b1 Ehd1 Ehd2 Ehd3 Phactr2 Stxbp2 Cxadr Stxbp3 Selplg Plcg2 Tfpi Itgax Vti1b Chid1 Abcc4 Prkch Prkce S100a10 Cfd A1bg Gp6 Agrn Gp5 Glg1 Rab27b Gp9 F13b Prkg1 Serpine1 Islr Pcyox1l Hrg Olr1 Slc16a3 Slc16a8 Mgll Slc16a1 F3 F7 F9 Lhfpl2 Pik3r6 Gas6 Sytl4 Ly6g6f Ceacam1 Ahsg Crk Spp2 Stx4 Jam3 Jam2 Serpina3n F10 F12 F11 Timp3 Serpinb6a Grb14 Fam3c Mpig6b Jaml Dgka Serpinf2 Dgkb Abhd6 Dgkd Dgke Dgkg F13a1 Anxa5 Serpine2 Anxa2 Qsox1 Itga3 Itga4 Brpf3 Esam Lgals3bp Dgkh Dgki Dgkk Lamp2 Dgkq Serpina10 Cd177 Dgkz Pde5a Itpr3 Itpr2 Itpr1 Pde10a Atp2a1 Wdr1 Atp2a3 Lyn Atp2a2 Daglb Yes1 Maged2 Src Spn Rhoa Trpc7 Trpc3 Endod1 Itgal Serpinb2 Atp2b1 Atp2b4 Atp2b3 Serpina5 Serpina4 Dagla Itgb2 Lcp2 Actn2 Habp4 Sri Cd244 Serpind1 Cdc37l1 Slc3a2 Mertk Atp1b1 Pde11a Atp1b3 Arrb2 Atp1b2 Arrb1 Tagln2 Thbd Smpd1 Itih4 P2rx6 Itih3 P2rx5 P2rx4 P2rx3 P2rx2 P2rx1 Rad51c Pros1 Serpinc1 Rad51b Aamp Trem1 Cd109 Nhlrc2 Mif Lck Fermt3 Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Pafah2 Igf2 Igf1 Sparc Apoh Raf1 Jak2 Gtpbp2 Orm1 Ecm1 Rhog Ola1 Rhob Gp1bb Ctsw Rac2 Gp1ba Ano6 Ano5 Actn4 Slc7a11 Slc7a10 Flna Cd48 Cd47 Irag1 Slc7a6 Tmsb4x Itga6 Slc7a7 Cd63 Slc7a5 Slc7a8 Slc7a9 Tor4a Cd74 Prtn3 Clec1b F11r Slc8a1 Slc8a2 Ppia Procr Slc8a3 Epcam Dok2 Tmx3 Fcer1g Pdpn Scg3 Sele Pde9a Proc Selp Sell Jchain Cyrib Abhd12 Sccpdh Plat Sirpa Plau Srgn Pde2a Pecam1 Nos1 Angpt2 Angpt4 Actn1 Proz Aplp2 Fcamr Cyb5r1 Mmrn1 Inpp5d Cd9 Pik3ca Plek Shc1 Sod1 Cav1 Ptpn6 Pik3r1 Pik3cb Plaur Pik3r2 Pik3r3 Kif18a Pik3r5 Pik3cg Cenpe Mfn1 Mfn2 Kif2a Kif2b Kif2c Ywhaz Aldoa Pdpk1 Alb Kif3a Apoa1 Apob Sdc4 Sdc3 Sdc2 Lrp8 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Gpc6 Sdc1 Bcar1 Ptpn1 Rapgef4 Rapgef3 P2rx7 Rasgrp2 Tbxa2r Ppbp Bsg Dock2 Pcdh7 Plcg1 Plg Klkb1 Racgap1 Cd44 Timp1 Mmp1b Rac1 A2m F2 Kdm1a Pf4 Mapk1 Nos3 Pla2g4a P2ry12 Gng10-ps1 Mag F2rl2 F2rl3 Ppp2cb Grb7 Ppp2ca Adra2b Prkaca Prkacb Prkcg Prkcd Gnai2 Gnai1 Prkca Gnai3 Gna11 Prkar1a Gna14 Prkar1b Calm3 Ppp2r5d Gng3 Vegfa Vegfd Gng5 Vegfc Gng4 Vegfb Gnaq Gng7 Gng8 Gngt1 Gnat3 Prkar2a Prkar2b F2r Ppp2r1b Ppp2r1a Pde1b Gnb2 Gnb1 Pde1a Gnb4 Kng1 Gnb3 Gnb5 Gng11 F8 Serpina1 Adra2a Adra2c Gata6 Ptgir Psap Zfpm1 Gata3 Gata1 Gata2 P2ry1 Actg1 Hdac1 H3-3b Vav3 Vav1 Vav2 Ptpn11 H2bc18 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 Gna13 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ppil2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Cdc42 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%10223601 Regulation of IGF Activity by IGFBP Ttgn1 Men1 Igfbp3 Fn1 Qsox1 Alb Serpina10 Notum Apoa1 Apoa2 Kng1 Mia3 Apoe P4hb Apob App Fgf23 Sdc2 Serpind1 Serpina1 Gpc3 Serpinc1 Ckap4 Igf2 Igf1 Cdh2 Il6 Prkcsh Adam10 Ctsg ENSRNOG00000069479 Gzmf C3 Hsp90b1 Fga Fgg Scg3 Ltbp1 Proc Plg Spp1 Bmp4 Ktn1 Fbn1 Aplp2 C4b Timp1 Megf11 Chgb ENSRNOG00000067174 Mmp1b Pdia6 C4 Ccn1 Amelx Pappa Lgals1 Csf1 Scg2 Apoa5 Meltf Mxra8 Fam20a LOC120093819 Fam20c Tf Klk6 Fuca2 Stc2 Wfs1 Apol7al1 Hrc Pcsk9 Ngfg F2 Ambn Mepe Cp Pappa2 Dnajc3 Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Penk Igfbp7 Igfbp6 Igfals Mfge8 Matn3 ENSRNOG00000066972 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tmem132a Afp Pnpla2 Mbtps1 Igfbp2 Igfbp5 Igfbp4 Tnc Golm1 Igfbp1 Amtn Dmp1 Mgat4a Nucb1 Sparcl1 Mmp2 Msln Vcan Cst3 Itih2 Apol9a Klk13 Gas6 Ahsg Spp2 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%10224661 ATP-dependent chromatin remodelers Snrpepl2 Ctnnb1 Rbbp4 Rbbp7 Rbm17 Ddx46 Ddx42 Cdc73 Chd8 Leo1 Ube2i Phf5a U2surp Skic8 Hdac2 H2ab2 Snrpa1 Arid1a Arid1b H2ac4 Actl6a Smarce1 ENSRNOG00000066901 Sf3a1 Sumo1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 H2ac18 Ss18 Dpf1 Bicral Bicra Ssrp1 Dpf2 Dpf3 Pbrm1 Brd9 Brd7 Actg1 Hist1h2bq Ss18l1 Smarcb1 Bcl7a Hdac1 Bcl7b Wdr5 Bcl7c Bcl11a Bcl11b Phf10 Snrpn H2aj Cherp Smarca2 Smarca4 H3-3b Hist3h2ba ENSRNOG00000068602 Chd3 Chd4 Smarcd1 Smarcd3 Mbd2 Smarcd2 Mta1 H2bc18 Mta2 Mta3 Mbd3 H2az2 Cbx3 H2bc4 Hist1h4m Gatad2a H2bc1 Gatad2b Smarcc1 Hist1h2ai Puf60 Smndc1 Snrpf Snrpg Snrpb Nr2c2 Fam124b Zmynd8 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp Cbx1 Ctr9 Paf1 Phf6 Zfp592 Ctcf Cdk2ap1 Snrpd1 Nr2f2 Chd1 Chd2 Chd5 Chd6 Chd7 Tcf19 Dhx15 Pwwp2a Snrpd3 Mbd3l1 Mbd3l2 Zfp687 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%10222681 Cytosolic sulfonation of small molecules Tpst1 Tpst2 Sult2b1 Sult1a1 Sult1c2 Sult1b1 Bpnt2 Sult6b1 Sult4a1 Sult2a2 Bpnt1 Sult2a1 Sult2a6 Abhd14b Podxl2 Sult1e1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223547 NCAM1 interactions St8sia4 Col4a1 Col4a2 Ncam1 St8sia2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-RNO-1638091.1 Heparan sulfate heparin (HS-GAG) metabolism Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Gpc6 Idua Naglu Ids Hpse2 Hpse Sgsh Sdc1 Ctsl Hs3st4 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Ext2 Ext1 Slc35d2 Sdc4 Sdc3 Sdc2 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 96%10225047 MET activates PTPN11 Hgf Grb2 Ptpn11 Met Gab1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%10225353 Inactivation of CSF3 (G-CSF) signaling Jak2 Uba52 Eloc Ube2d1 Elob Syk Lyn Socs3 Rps27a Hck Csf3 Tyk2 Cul5 Ube2d3 Ube2d2 Ubb Socs1 Ubc DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222475 DAG and IP3 signaling Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkce Prkar2a Prkar2b Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10222835 MyD88 cascade initiated on plasma membrane Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 INTERCONVERSION OF POLYAMINES%REACTOME%R-RNO-351200.1 Interconversion of polyamines Smox Sat1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%10222245 Signaling by Rho GTPases Mtr Ywhag Frs2 Frs3 Acbd5 Sptbn1 Ptk2 Aldh3a2 Mapk3 Sptan1 Emd Grb2 Rbmx Sos1 Tra2b Usp9x Iqgap2 Ppp2r5b Ppp2r5a S100a9 Ppp1cc Abcd3 Ppp1cb Ppp2r5e Map3k11 Mapk14 Prkcb Rasgrf2 Mapk11 Ywhab Rasal2 Ncoa2 Csk Itgb1 Atp6ap1 Kif5a Kif5b Dock5 Dock6 Steap3 Dock3 Dock4 Dock7 Tfrc Dock8 Pik3c3 Klc1 Pik3r4 Klc4 Klc3 Klc2 Dbt Dock10 Dock11 Rab7a Ywhae Lamtor1 Lbr Kidins220 Als2 Gopc Rhoq Vamp3 Sh3rf1 Ckb Snap23 Pde5a Pak1 Pak2 Tpm4 Rhoa Ngef Mylk Dlg4 Ncf1 Zap70 Ncf2 Ncf4 Lck AABR07021573.2 Rhog Rhob Pard6b Pard6a Rac2 Fermt2 Flna Cyba Cybb Dst Actn1 Pik3ca Arhgap32 Cav1 Farp2 Pik3r1 Pik3r2 Pik3r3 Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Sfn Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Rbbp6 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Ywhaq Ywhah Birc5 Aaas Ercc6l Ranbp2 Ckap5 Ywhaz Spdl1 Nup133 Bub1 Itgb3bp Hmox2 Zwilch Pdpk1 Ctnnb1 Men1 Garre1 Shmt2 AABR07032856.1 Osbpl11 Nisch Uaca Nckap1l Wipf3 Wipf1 Itsn2 Dvl1 Mrtfa Dvl2 Stmn2 Dvl3 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Flot2 Samm50 Flot1 Fam169a Amigo2 Noxa1 Baiap2l2 Rapgef1 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 Ralgapa1 Cdc37 Chn2 Esyt1 Trip10 Wwp2 Fam135a Abi2 Abi1 Wdr11 Tuba1b Msi2 Ppp1r12b Stip1 Cpsf7 Ppp1r12a Phip Akap12 Stk38 Vrk2 Ppp1r14a Abl2 Slc1a5 Lin7b Cops4 S100a8 Arpc3 Cops2 Arpc2 Srgap1 Ubxn11 Arhgap45 Slk Cpd Cdh1 Arpc5 Cavin1 Daam1 Ctnna1 Arpc4 Pgrmc2 Picalm Tex2 Brk1 Bcr Ndufs3 Arhgap6 Jup Dsp Arhgap5 Arhgap15 Arhgap4 Arhgap17 Dsg1 Sowahc Arhgap1 Dsg2 Stom Evl Arap1 Rhobtb2 Arap3 Rhobtb1 Arap2 Arhgap25 Arhgap9 Srf Arhgap8 Arhgap27 Mcam Slitrk5 Slitrk3 Pld1 Arhgap33 Ccdc115 Wasf3 Rtkn Wasf2 Rhpn1 Hsp90ab1 Wasf1 Rhpn2 Stk10 Plekhg1 Ralbp1 Stard8 Prc1 Maco1 Rnf20 Ddrgk1 Cct6a Faf2 Cdc42bpa Arhgdib Gmip Cdc42bpb Slc4a7 Anln Arhgap10 Arpc1b Actr2 Iqgap3 Arpc1a Diaph3 Actr3 Diaph1 Arhgap19 Btk Arhgap18 Pfn1 Depdc1b Senp1 Cit Pfn2 Vangl2 Fam13a Arhgef28 Twf1 Epsti1 C1qbp Arhgap22 Cpne8 Arhgap21 Nckap1 Arhgap20 Nipsnap2 Arhgap26 Ankle2 Arhgap24 Cyfip2 Arhgap23 Cyfip1 Arhgap29 Rhoh Arhgap28 Rhof Rhoc Ophn1 Rhoj Stbd1 Rac3 Dock2 Def6 Kif14 Vapb Rhou Pcdh7 Fam13b Scai Myo9b Nckipsd Emc3 Arhgap11a Cct7 Pak5 Myo9a Arhgap31 Ccdc88a Arhgap30 Tmem59 Prex2 Mtx1 Noxo1 Actc1 Arhgap35 Mpp7 Ankrd26 Fmnl3 Tagap Srgap2 Racgap1 Srgap3 Plekhg6 Ocrl Tmod3 Tmem87a Plekhg3 Cdc42ep1 Bcap31 Cdc42ep4 Ktn1 Plxna1 Farp1 Syde1 Dlc1 Syde2 Pld2 Stard13 Arhgap40 Elmo2 Pkn2 Rras2 Rock2 Arhgef7 Dnmbp Rock1 Nsfl1c Pkn1 Ccdc187 Arhgap44 Plxnd1 Arhgap42 Basp1 Tjp2 Ddx4 Spata13 Kdm4c Nck2 Rnd2 Rac1 Rnd3 Pak3 Rnd1 Git1 Swap70 Arhgdig Baiap2 Kctd13 Fnbp1 Bltp3b Spen Hsp90aa1 Armcx3 Ndufa5 Add3 Tor1aip1 Sema4f Lmnb1 Ptpn13 Fmnl2 Fmnl1 Sh3bp1 Prag1 Limk1 Vim Cdc20 Hspe1 Kdm1a Tnfaip1 Mad2l1 Bub1b Nck1 Aurkb Actb Prkcz Plk1 Mapk1 Stam Ar Mcf2 Arhgdia Cftr Lman1 Scfd1 Ppp2cb Grb7 Ppp2ca Prkcd Arfgap3 Prkca Calm3 Ppp2r5d Hgs Ppp2r1b Ppp2r1a Stam2 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Ccp110 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Stx5 Ykt6 Ckap4 H2ab2 H2ac4 Arl13b Abl1 ENSRNOG00000066901 Cct2 H2ac18 Hist1h2bq Actg1 Ptk2b H2aj Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 H3-3b Arhgef16 Hist3h2ba Arhgef11 Arhgef10 Arhgef12 ENSRNOG00000068602 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 H2bc18 H2az2 Sos2 Kalrn H2bc4 Hist1h4m H2bc1 Arhgef6 Hist1h2ai Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Gja1 Ddx39b Myo6 Cltc Vcp Hnrnpc Cdc42ep2 Cdc42ep3 Cdc42 Cul3 Srrm1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors Mtr Mmachc Slc22a13 Nfs1 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Abcc1 Mthfd2 Folr2 Gphn Pank4 Mocos Gsto2 Shmt2 Cyb5a Lrp2 Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Nampt Shmt1 Ldlrap1 Pdxk Naxe Slc52a2 Slc52a3 Lrpl1 Mccc1 Btd Mccc2 Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Bst1 Vnn1 Cblif Tcn2 Fpgs Mmut Mthfs Cubn Mthfr Slc25a32 Slc46a1 Pank3 Slc23a1 Pank2 Mthfd1l Pank1 Slc23a2 Ppcs Naprt Dcakd Mmadhc Ppcdc Pcca Coasy Rfk Pccb Acp5 Aox1 Slc2a1 Slc2a3 Nadk2 Nudt12 Mthfd2l Amn Nmrk1 Mocs3 Slc25a16 Pc Hlcs Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Mtrr Flad1 Gsto1 Mmab Nt5e Rnls Enpp1 Mocs1 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10224073 Prolactin receptor signaling Prlr Sh2b1 Jak2 Cul1 Btrc Skp1 Rbx1 Ghr Gh1 Prl ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224711 Anchoring of the basal body to the plasma membrane Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Rpgrip1l Septin2 Kif24 Ttbk2 Tctn3 Fbf1 Tctn1 Akap9 Tctn2 Iqcb1 B9d1 Cep89 Mks1 Ahi1 Nphp4 Cep83 Nphp1 Ofd1 Sclt1 Tmem216 Prkar2b Ppp2r1a Hsp90aa1 Rab11a Pafah1b1 Cep97 Dync1h1 Csnk1d Ccp110 Dync1i2 B9d2 Nde1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Rab3ip SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 96%10224495 SUMO is proteolytically processed Sumo3 Senp1 Senp5 Senp5l1 Sumo2 Senp2 Sumo1 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides Try10 Prss2l1 Pla2g2a Try5 LOC102554637 Clu Prss2 Prss3 Elane Prss1 Atp7a Defb41 Ccr6 Defb42 Np4 Defb43 Defb44 Defa24 Svs3b Ear1 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Pglyrp2 Reg3a Reg3b Pglyrp3 Pglyrp4 Defa31 Stath Reg3g Bpi Defa Camp Bpifb2 Chga Ltf Lyz1 Tlr1 Bpifa1 Bpifa2 Defb14 Defb17 S100a9 Defb18 Art1 S100a8 Tlr2 Defb21 Defb5 Rnase6 Defb24 Defb1 Slc11a1 Defb25 Eppin Defb28 Defa9 Cd4 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Ctsg Prtn3 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223955 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Chrnb4 Chrna4 Chrnb2 Chrnd Chrne Chrna3 Chrng GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%10222003 Gluconeogenesis Aldoa Pgk2 Pck1 Pck2 Gpi G6pc1 Eno3 Eno2 Eno4 G6pc3 Pgk1 Tpi1l2 Pc Pgam2 Pgam1 Slc37a4 Tpi1 Slc37a2 Slc37a1 Fbp1 Fbp2 Aldob Gapdhs Aldoc ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ikbkg Psmb1 Psmb3 Psmb2 Uba52 Nfkb1 Fbxw11 Btrc Psma7 Rela Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Malt1 Ubc Bcl10 Nfkbie Psmb6l1 Rel Psmd7 Nfkbib Psmd6 Psmd8 Psmd2 Prkcb Psmd1 Adrm1 Cul1 Nfkbia Chuk G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10221993 G2 M DNA damage checkpoint Ywhag Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Ccna1 Ccna2 Hist3h2ba Blm Wrn Sfn H2bc4 Hist1h4m H2bc1 Dna2 Ccnb1 Pias4 Ube2n Mre11 Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rpa1 Rad9b Rpa2 Bard1 Wee1 Top3a Rpa3 Tp53 Rad17 Ywhae Rfc5 Rfc3 Rfc4 Cdc25c Rfc2 Atm Atr Cdk1 Tp53bp1 Exo1 Rmi2 Rmi1 Ywhaq Brip1 Ywhah Brcc3 ENSRNOG00000066901 Ywhab Herc2 Rnf168 Ywhaz ABRAXAS1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%10223025 SHC1 events in EGFR signaling Egfr Shc1 Ereg Hbegf Btc Nras Grb2 Egf Kras Sos1 Hras Tgfa Areg PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism Exoc3 Cpb2 Cpa3 Exoc4 Exoc5 Exoc6 Ins2 Exoc1 Exoc2 Exoc7 Exoc8 Gh1 Fshb Pomc Tshb Spcs3 Dpp4 Spcs1 Spcs2 Gpr119 Ffar1 P4hb Lhb Cga Grp Igf1 Bche Ero1b Mboat4 Ffar4 Ghrl Inha Pla2g7 Slc30a5 Slc30a8 Pcsk1 Gcg Lep Inhba Sec11c Gip Inhbb Inhbc Sec11a Inhbe Atp6ap2 Ctsd Ace Mme Ctsg Gzmf Agt Ren1 Ace2 Enpep Ctsz Cma1 Ces1d Ins1 Cpb1 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%10224507 SUMO E3 ligases SUMOylate target proteins Nup133 Nup210 Suz12 Nup155 Nup153 Mrtfa Sumo2 Ctbp1 Blm Nop58 Ikbkg Pias4 Ube2i Nfkb2 Rela Hdac2 Parp1 Hdac4 Pcna Xrcc4 Nfkbia Ikbke Tp53bp1 Nr1i2 Smc6 Smc5 Smc3 Pias3 Ddx17 Sp140 Pias1 Pias2 Ring1 Nsmce4a Casp8ap2 Hic1 Eid3 Herc2 Uhrf2 Phc2 Rnf168 Nr3c2 Sumo1 Cetn2 Nr3c1 Nsmce1 Phc1 Nsmce2 Cbx4 Sumo3 Xpc Zfp131 Sp3 Cbx2 Vdr Esr1 Stag2 Phc3 Stag1 Dnmt1 L3mbtl2 Nr1h4 Daxx Rad52 Safb Mageb10 Sp100 Ing2 Ppara Sin3a Top2b Top2a Top1 Trim28 Trim27 Pcgf2 Bmi1 Thrb Thra Brca1 Mbd1 Satb2 Satb1 Park7 Smc1a Hdac1 Nr5a1 Tfap2c Ep300 Nrip1 Rnf2 Mitf Tdg Mta1 Nr1h3 Nr1h2 Hist1h4m Rxra Pml Vhl Pgr Cdca8 Incenp Aurkb Rpa1 Nup93 Nup50 Nup35 Rara Nup54 Nup98 Npm1 Nup58 Rangap1 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Hnrnpc Nup85 Nup42 Hnrnpk Nr5a2 Nup62 Nup43 Nup88 Birc5 Ar Aaas Ranbp2 Nup214 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%10223257 Signalling to ERK5 Mapk7 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%10222887 TICAM1-dependent activation of IRF3 IRF7 Irf3 Irf7 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME%R-RNO-400206.1 Regulation of lipid metabolism by PPARalpha Fabp1 Ncoa2 Tbl1x Crebbp Ncor2 Carm1 Tgs1 Ppara Sin3a Sin3b Smarcd3 Med1 Hdac3 Tbl1xr1 Rxra REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription Phc1 Suz12 Cbx4 Eed Cbx2 Phc3 Rbbp4 Rbbp7 Bmi1 Hdac1 Maf1 Lamtor3 Mecom Lamtor2 Sall4 Hdac2 Rptor RragB Mtor Rheb Rnf2 Slc38a9 Chd3 Lamtor5 Chd4 Lamtor4 Rraga Lamtor1 Mta1 Rragc Ring1 Mta2 Rragd Mta3 Mbd3 Mlst8 Ezh2 Phc2 Cbx6 Gatad2a Gatad2b GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223637 Glyoxylate metabolism and glycine degradation Grhpr Hao1 Aldh4a1 Got2 Amt Gnmt Gcsh Dao Agxt2 Ddo Prodh2 Dld Agxt AC132020.1 Ogdh Dlst Kgd4 NUCLEAR RNA DECAY%REACTOME%R-RNO-9930044.1 Nuclear RNA decay Ncbp2 Ncbp1 Dis3 Zcchc8 Zfc3h1 Papolg Srrt Mphosph6 Rbm26 Rbm27 Zc3h18 Exosc10 Rbm7 C1d Zc3h4 Zc3h3 Exosc9 Exosc8 Exosc5 Exosc4 Ythdc2 Exosc7 Ythdc1 Exosc6 Exosc1 Exosc3 Exosc2 Pabpn1 Wdr82 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 96%10223031 Signaling by FGFR2 Ppp2cb Ppp2ca Hnrnph1 Frs2 Plcg1 Frs3 Fgfr2 Fgf16 Fgfbp3 Fgf17 Fgfbp1 Pik3ca Fgf18 Shc1 Braf Rbfox2 Ppp2r1a Esrp2 Fgf10 Esrp1 Mapk3 Tial1 Tia1 Pik3r1 Src Spry2 Mknk1 Nras Rps27a Grb2 Kras Sos1 Polr2c Hras Polr2a Ptpn11 Polr2b Fgf20 Polr2g Fgf23 Polr2h Polr2e Fgf22 Polr2f Polr2i Gab1 Polr2j Ncbp2 Ncbp1 Uba52 Gtf2f2 Hnrnpa1 Gtf2f1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Fgf7 Ubc Fgf9 Ptbp1 Cbl Mapk1 Hnrnpf ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%10225269 Activated NTRK3 signals through PI3K Src Ntrk3 Ntf3 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9034793.1 Activated NTRK3 signals through PLCG1 Plcg1 Ntrk3 Ntf3 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10222989 Sulfur amino acid metabolism Mtr Slc25a10 Cbs Cth Mpst Usf1 Sqor Ethe1 Fmo1 Mri1 Suox Ado Txn2 Bhmt Ahcy Mtap Enoph1 Mtrr Tst Adi1 Bhmt2 Gadl1 Mat1a Cdo1 ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%10224873 ERBB2 Regulates Cell Motility Diaph1 Memo1 Egfr Erbb2 Egf Erbb3 Ereg Nrg2 Nrg3 Hbegf Btc Rhoa BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 96%10222337 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Hadha Hadhb Acadl Echs1 Hadh G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-RNO-69615.1 G1 S DNA Damage Checkpoints Zfp385a Gsk3b Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Skp1 Psmb5 Plk3 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Phf20 Uba52 Fbxw11 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Chek1 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Mapk14 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Atm Cop1 Mdm4 Mapk11 Csnk1e INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-RNO-9006925.1 Intracellular signaling by second messengers Suz12 Erbb2 Eed Erbb3 Ereg Pdpk1 Frs2 Rbbp4 Btc Rbbp7 Tnks2 Pdgfa Pdgfb Xiap Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Creb1 Fgf17 Fgf18 Fgf19 Fgf10 Hbegf Mapk3 Ntrk3 Ntf3 Stub1 Rnf146 Grb2 Fyn Tnks Tgfa Fgf20 Wwp2 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Lamtor3 Lamtor2 Hgf Egfr Hdac2 Irak1 Pdgfrb Pdgfra Chuk Kl Flt3 Nrg2 Nrg3 Met Prex2 Egf Trib3 Them4 Insr Rac1 Psma4 Akt3 Psma3 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Chd3 Cd19 Rps27a Chd4 Psmd12 Psmd11 Tsc2 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Psmb5 Gatad2a Psmb4 Gatad2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Strn Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Prkce Cdkn1b Psmd7 Rptor Psmd6 RragB Psmd8 Psmd2 Psmd1 Mtor Adrm1 Rheb Slc38a9 Mapk1 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Pik3r6 Rragd Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Mlst8 Adcy7 Camkk2 Ins1 Adcy8 Adcy5 Adcy6 Ppp2cb Ins2 Ppp2ca Foxo4 Adcy9 Nedd4 Prkaca Prkacb Prkcg Prkcd Prkca Il33 Camk4 Prkar1a Prkar1b Calm3 Ppp2r5d Grk2 Usp7 Il1rap Irak4 Mkrn1 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Pde1b Pde1c Src Pde1a Otud3 Pten Usp13 Lck Rhog Rac2 Ring1 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Esr1 Phc3 Csnk2a2 Trim27 Csnk2a1 Bmi1 Hdac1 Maf1 Mecom Sall4 Csnk2b Pik3ca Gab2 Pip5k1c Pik3r1 Pik3cb Rnf2 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pml Pik3r5 Pik3cg Ier3 Irs2 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Rps6kb2 Pik3ap1 Foxo6 Cd28 Icos Sgk1 Nr4a1 Ntf4 Pip5k1a Frk Rictor Cd86 Cd80 Prr5 Bdnf Il1rl1 Trat1 Casp9 Myd88 Mapkap1 Ntrk2 Foxo1 Ezh2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10222569 Integrin cell surface interactions Jam2 F11r Fgb Fga Fgg Itga2b Col13a1 Itgb8 Itgb6 Spp1 Cd44 Itgb1 Fn1 Itga3 Itga4 Pecam1 Itgb3 Fbn1 Col4a1 Col4a2 Itga1 Itgal Itgb2 Cdh1 Tnc Thbs1 Madcam1 Itgax Comp Itgae Itgad Itga9 Itgb7 Icam1 Icam5 Icam4 Icam2 Itga2 Itga10 Col4a4 Vcam1 Ibsp Col18a1 Cd47 Bsg Itga6 Itga8 Itgav Vtn Jam3 Lum VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamin B6 activation to pyridoxal phosphate Pdxk Pnpo Aox1 MALATE-ASPARTATE SHUTTLE%REACTOME%R-RNO-9856872.1 Malate-aspartate shuttle Slc25a22 Got2 Got1 Mdh1 Mdh2 Slc25a11 Slc25a12 Slc25a13 Slc25a18 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events Adcy5 Adcy6 Adra2b Adcy9 Adra2a Adra2c Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Rgs20 Rgs17 Gnb4 Rgs16 Gnb3 Gnaz Gnb5 Gng11 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%10224727 RHO GTPases activate KTN1 Klc1 Klc4 Kif5a Rhog Rac1 Kif5b Ktn1 Klc3 Klc2 Cdc42 Rhoa ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 96%10223841 Zinc efflux and compartmentalization by the SLC30 family Slc30a1 Slc30a5 Slc30a8 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176409.1 APC C:Cdc20 mediated degradation of mitotic proteins Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-RNO-1793185.1 Chondroitin sulfate dermatan sulfate metabolism Chst3 Dsel Ust Dse Cspg5 Bgn Cspg4 Chst14 Chst15 Idua Hyal4 Hyal3 Ids Hyal1 Gusb Glb1 Arsb Bcan Vcan Ncan Dcn Glb1l Chst11 Chst12 Chsy1 Chsy3 Chst13 Chpf Glb1l3 Glb1l2 Csgalnact2 Chst7 Chst9 Hexa Hexb DUAL INCISION IN GG-NER%REACTOME%R-RNO-5696400.1 Dual Incision in GG-NER Chd1l Ddb2 Gtf2h2 Gtf2h1 Uba52 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Ercc1 Ercc4 Pole3 Pole2 Pole4 Rpa1 Rpa2 Polk Ubb Rpa3 Ubc Pole Parp2 Parp1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Pold4 Pold3 Rps27a Xpa Ddb1 Cul4a Cul4b O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%10224019 O-linked glycosylation Qtgal Adamts1 Adamts3 Adamts2 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Pofut3 Pofut4 Thsd4 Cfp Spon2 Spon1 Sspo B3glct B3gnt9 B3gnt8 B3gnt6 B3gnt5 Galnt1 Galnt2 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5a Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Muc15 Adamts19 Muc13 Adamts10 Muc19 Sbspon A4gnt Muc5b Adamts12 Muc4 Muc6 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Adamts20 Thsd7b Thbs1 Mgat5b B3galnt2 Pomk Pomgnt2 B3gnt7 B3gnt2 B4galt5 B4galt6 Adamts5 B4gat1 Adamts4 Pomt1 Pomt2 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Fktn Pomgnt1 Mmrn1 St6galnac3 St6galnac2 St3gal4 St3gal2 St3gal3 Slc35a1 St3gal1 St6gal1 B3gnt3 Galnt3 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%10224371 RHO GTPases Activate WASPs and WAVEs Nckipsd Arpc3 Nck1 Arpc2 Actb Arpc5 Arpc4 Brk1 Actg1 Nckap1l Wipf3 Wipf1 Wasf3 Wasf2 Wasf1 Rac1 Baiap2 Ptk2 Mapk3 Arpc1b Actr2 Arpc1a Mapk1 Actr3 Grb2 Btk Abl1 Cdc42 Nckap1 Abi2 Abi1 Cyfip2 Cyfip1 TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions F11r Pard6g Prkci Pard6b Pard6a Pard3 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 Ppp2cb Ppp2ca Frs2 Spred1 Plcg1 Frs3 Spred2 Fgfrl1 Fgfr1 Fgf17 Pik3ca Fgf18 Shc1 Braf Ppp2r1a Fgf10 Mapk3 Pik3r1 Src Spry2 Mknk1 Nras Rps27a Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Fgf22 Gab1 Tgfbr3 Uba52 Gipc1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Flrt1 Ubc Flrt3 Fgf9 Flrt2 Cbl Mapk1 Kl INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223905 Interleukin-7 signaling Irs2 Stat3 Brwd1 Tslp Il7 Smarca4 Il7r Pik3r1 Jak3 Pik3r2 Pik3r3 Irs1 H2bc18 Stat5a Stat5b TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-RNO-174362.1 Transport and metabolism of PAPS Slc26a11 Slc26a2 Slc26a1 Slc35b3 Slc35b2 Papss2 Papss1 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-RNO-5357786.1 TNFR1-induced proapoptotic signaling Tbk1 Traf2 Sharpin Tnf Otud1 Ikbke Tnfrsf1a Tradd Mib2 Birc2 Cyld Spata2 Rnf31 Ripk1 Otud7b Fadd Rbck1 Usp2 Xiap Usp4 Usp21 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins Prkaca Prkacb Avp Myo5b Aqp1 Aqp4 Prkar1a Aqp3 Aqp2 Prkar1b Gng3 Gng5 Gng4 Gng7 Avpr2 Gng8 Gngt1 Prkar2a Prkar2b Gnb2 Gnb1 Gnb4 Gnb3 Rab11a Gnb5 Gng11 Gng10-ps1 Gnas IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222217 IRS activation Irs2 Ins2 Insr Irs1 Grb10 Ins1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-RNO-9818027.1 NFE2L2 regulating anti-oxidant detoxification enzymes Srxn1 Prdx1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs Alox12 Ptgs2 Alox5 Alox15 CO-INHIBITION BY BTLA%REACTOME%R-RNO-9927353.1 Co-inhibition by BTLA Grb2 Btla Ptpn11 Ptpn6 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-RNO-2454202.1 Fc epsilon receptor (FCERI) signaling Pdpk1 ENSRNOG00000070986 Lat2 Prkcq Cdc34 Calm3 Ube2d2 Pak1 Pak2 Mapk3 Lyn Nras Grb2 Kras Sos1 Hras Mapk9 Ikbkb Lcp2 Mapk8 Traf6 Ikbkg Map3k7 Ube2n Nfkb1 Fbxw11 Fos Rela Map3k1 Fcer1a Txk Ppp3ca Ppp3cb Itk Map2k7 Nfatc1 Nfatc3 Malt1 Nfatc2 Bcl10 Ppp3r1 Grap2 Ms4a2 Tec Jun Nfkbia Btk Tab3 Tab2 Tab1 Chuk Lat Mapk10 Fcer1g Plcg1 Pik3ca Shc1 Rac1 Psma4 Gab2 Psma3 Psma6 Pik3r1 Pik3cb Psma5 Psma2 Psma1 Rps27a Vav3 Pik3r2 Psmd12 Psmd11 Vav1 Vav2 Psmd14 Psmd13 ENSRNOG00000069193 AABR07065813.1 Skp1 ENSRNOG00000062915 Igll1 Psmb5 ENSRNOG00000065191 Psmb4 Ighl12 Psmb7 ENSRNOG00000062682 Psmb6 ENSRNOG00000070812 ENSRNOG00000070415 Psmb1 ENSRNOG00000070810 Psmb3 ENSRNOG00000066926 Psmb2 ENSRNOG00000066406 Uba52 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ube2d1 Syk Btrc Iglc1 ENSRNOG00000070159 Psma7 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Psmc5 Psmc2 ENSRNOG00000066971 Psmc1 ENSRNOG00000063341 Psmc4 ENSRNOG00000065283 Psmc3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Ubb ENSRNOG00000067679 ENSRNOG00000070832 Ubc ENSRNOG00000064041 ENSRNOG00000064481 Psmb6l1 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Psmd7 ENSRNOG00000063713 ENSRNOG00000062820 Psmd6 ENSRNOG00000064886 Psmd8 ENSRNOG00000064490 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 Psmd1 ENSRNOG00000067603 Adrm1 Cul1 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 ABACAVIR ADME%REACTOME%R-RNO-2161522.1 Abacavir ADME Slc22a3 Slc22a2 Slc22a1 Adh1 Nt5c2 INTERLEUKIN-37 SIGNALING%REACTOME%R-RNO-9008059.1 Interleukin-37 signaling Stat3 Tbk1 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope (NE) Reassembly Nup133 Nup155 Ppp2ca Tubb4b Tubb4a Ppp2r1a Emd Lmnb1 Ccnb2-ps2 Tuba1b Chmp2a Ccnb1 Ppp2r2a Ube2i Vrk2 Nup93 Tuba1a Nup35 Kpnb1 Nup98 Tuba1c Tubal3 Rangap1 Nup37 Rcc1 Pom121 Chmp2b Tuba4a Cc2d1b Nup205 Spast Tubb2b Nup107 Tubb2a Sec13 Ist1 Chmp3 Nup188 Vrk1 Chmp7 Cdk1 Nup160 Chmp6 Lmna Ahctf1 Vps4a Ndc1 Sirt2 Tuba8 Chmp4c Nup85 Tuba3b Chmp4bl1 Lbr Tubb6 Nup43 Tubb3 Tubb1 Banf1 Ran Ccnb2 Ankle2 Sumo1 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%10222583 Platelet calcium homeostasis Slc8a1 Slc8a2 Slc8a3 Itpr3 Itpr2 P2rx7 Itpr1 Atp2a1 Atp2a3 P2rx6 Atp2a2 P2rx5 P2rx4 P2rx3 Trpc7 P2rx2 P2rx1 Trpc3 Atp2b1 Atp2b4 Atp2b3 Calm3 Sri PEXOPHAGY%REACTOME%R-RNO-9664873.1 Pexophagy Pex5 Rps27a Usp30 Map1lc3b Uba52 Ubb Sqstm1 Nbr1 Atm Ubc SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10224407 Synthesis of 12-eicosatetraenoic acid derivatives Alox12b Alox12 Gpx4 Alox15 Gpx2 Aloxe3 Gpx1 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-RNO-9958825.1 Activation of STAT3 by cadherin engagement Arhgef4 Hace1 Uba52 Stat3 Nfkb1 Ctnnb1 Ctsb Birc2 Cbll1 Rela Ctss Cdh1 Ctnna1 Ctsl Jup Ctnnd1 Xiap Ubb Ubc Cdh11 Jak2 Vcl Tiam1 Rac1 Farp2 Il6 Src Il6r Rps27a Vav2 Tyk2 Cdc42 Il6st Rnf19b NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223185 NADE modulates death signalling Ywhae Casp3 Casp2 Ngfr Ngf Bex3 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-RNO-9913635.1 Strand-asynchronous mitochondrial DNA replication Polrmt Polg2 Twnk Ssbp1 Polg NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 Wwox Aph1b Esr1 Psenen Psen1 Psen2 Yap1 Stat5a Ncstn Src Aph1a CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions Cyp2f2 Cyp2s1 Cyp2d4 Cyp2a2 Cyp2a1 Cyp2a3 Cyp2c66 Cyp2e1 Cyp2c11 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-RNO-174143.1 APC C-mediated degradation of cell cycle proteins Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10223441 HDL assembly Bmp1 Abca1 Zdhhc8 Prkaca Prkacb A2m Apoa1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-RNO-9933939.1 Formation of the polybromo-BAF (pBAF) complex Smarcc1 Phf10 Smarca2 Smarca4 Actl6a Smarcd1 Smarce1 Smarcd3 Smarcd2 Pbrm1 Brd7 Actg1 Bcl7a Smarcb1 Bcl7b Bcl7c PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-RNO-76009.1 Platelet Aggregation (Plug Formation) Apbb1ip Fgb Fga Adra2b Fgg Pdpk1 Itga2b Adra2a Syk Adra2c Rasgrp1 Csk Tln1 Fn1 Itgb3 Bcar1 Shc1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Ptk2 Akt1 Src Grb2 Rap1a Rap1b Sos1 Crk SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%10223045 Signaling by FGFR4 Ppp2cb Ppp2ca Uba52 Frs2 Plcg1 Frs3 Klb Fgf2 Fgf1 Fgf4 Fgf6 Ubb Fgf8 Ubc Fgfr4 Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Fgf19 Braf Ppp2r1a Mapk3 Src Spry2 Pik3r1 Mknk1 Cbl Nras Mapk1 Rps27a Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Gab1 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%10223299 ERKs are inactivated Dusp7 Dusp6 Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Mapk3 Vrk3 Mapk1 Ppp2r5d Mapk7 Dusp3 Dusp4 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism Nup133 Nup210 Nup155 Nup153 Miox Ip6k3 Isyna1 Itpka Itpkc Itpkb Plcg1 Impa2 Impa1 Inpp5a Inpp5b Plch1 Pld4 Plcd1 Plcd4 Ocrl Inpp5j Plcd3 Nudt4 Calm3 Nudt3 Synj1 Plcz1 Plce1 Inpp1 Ppip5k1 Ppip5k2 Inpp5d Inppl1 Ippk Ipmk Ip6k1 Ip6k2 Inpp4a Inpp4b Itpk1 Pten Minpp1 Nup93 Nup50 Plcg2 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Plcb4 Nup160 Plcb3 Rae1 Ndc1 Plcb2 Plcb1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222905 GABA receptor activation Adcy5 Adcy6 Adcy9 Gabrr1 Gabrr3 Gnai2 Gabrr2 Gnai1 Gabrq Gnai3 Gabrb1 Gabrb3 Gabrb2 Gng3 Gnal Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Gnat3 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Arhgef9 Gabrg2 Gabrg3 Gng10-ps1 Adcy3 Gabra4 Adcy4 Gabra3 Adcy1 Gabra6 Adcy2 Gabra5 Gabra2 Adcy7 Gabra1 Adcy8 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 96%10223619 Receptor-type tyrosine-protein phosphatases Il1rap Slitrk5 Slitrk6 Slitrk3 Slitrk4 Slitrk1 Slitrk2 Ppfibp2 Ppfibp1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Ptprs Ntrk3 Lrrc4b Il1rapl1 Il1rapl2 Ptprf ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-RNO-68616.1 Assembly of the ORC complex at the origin of replication Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Orc4 H2bc18 Orc6 Orc1 H2az2 Hist1h2bq Orc3 ENSRNOG00000066901 Orc2 H2bc4 Hist1h4m Kpnb1 H2bc1 Kpna6 Kpna1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates Txn Rrm2b Txnrd1 Dtymk Nudt13 Dut Rrm1 Tyms Rrm2 Ak1 Gsr Nme3 Ak2 Nme2 Ak5 Glrx Ak4 Ak7 Ak6 Ak9 Nme1 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 96%10223641 Beta-oxidation of pristanoyl-CoA Acoxl Crat Acox2 Amacr Acox3 Acot8 Crot Hsd17b4 Scp2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222277 SLC-mediated transmembrane transport Slco2b1 Slco2a1 Slco4c1 SLC16A2 Slco1c1 Slc15a1 Ctns Slc15a3 Slc15a4 Slc1a5 Slc26a2 Slc26a1 Slc35b3 Slc35b2 Slc26a11 Slc22a3 Arl2 Slc4a7 Slc35d2 Bsg Slc13a4 Slc13a1 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc67a1 Slc44a2 Slc4a2 Slc4a4 Slc4a3 Avp Slc4a5 Slc4a8 Slc33a1 Slc4a9 Slc10a6 Slc22a8 Slc22a7 Slc45a3 Slc5a6 Slc12a1 Slc35d1 Slc5a8 Slc12a4 Slc22a6 Slc12a5 Lcn12 Slc12a2 Slc22a5 Slc12a3 Slc22a4 Slc12a6 Slc5a1 Slc12a7 Slc5a3 Slc34a3 Slc5a2 Slc5a4 Slc5a7 Slc35c1 Slc11a2 Apod Slc27a1 Arl2bp Slc25a26 Slc25a29 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Emb Slc39a8 Slc2a1 Slc39a7 Slc2a3 Slc39a6 Slc16a7 Slc2a13 Slc6a6 Slc2a12 Slc16a3 Slc2a10 Slc16a8 Slc31a1 Fgf21 Slc16a1 Slc28a3 Slc28a2 Slc28a1 Slc20a2 Slc20a1 Slc43a1 Slc43a2 Slc17a1 Slc7a3 Slc7a1 Mfsd4b4 Slc29a3 Slc29a2 Slc29a1 Slc29a4 Slc30a10 Slc25a1 Slc40a1 Slc14a2 Slc14a1 Slc26a6 Slc26a4 Slc26a3 Slc26a9 Slc8b1 Slc26a7 Slc41a2 Lcn9 Slc41a1 Slc1a1 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc1a7 Calm3 Slc1a6 Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc6a12 Slc9a9 Slc9a6 Slc9a7 Slc27a4 Slc27a6 Slc35b4 Slc5a10 Slc5a12 Slc5a11 Slc2a2 Slc2a4 Slc2a8 Slc2a7 Slc2a9 Slc35a3 Slc35a2 Slc39a14 Slc50a1 Slc24a5 Slc47a1 Slc24a4 Slc24a3 Slc22a2 Slc24a2 Slc6a19 Slc24a1 Slc6a5 Ahcyl2 Slc22a1 Slc22a15 Slc32a1 Vegp2 Slc6a7 Vegp1 Slc6a15 Slc22a12 Slc6a9 Slc22a16 Slc6a14 Slc3a1 Slc6a11 Slc13a5 Slc6a13 Sri Slc36a4 Slc6a20 Slc13a3 Slc25a18 Slc36a2 Slc25a22 Slc36a1 Slc6a2 Slc3a2 Slc13a2 Slc17a7 Slc4a10 Slc6a1 Slc16a10 Slc17a8 Heph Slc6a4 Slc25a5 Slc6a3 Slc25a4 Slc17a6 Slc34a1 Slc34a2 Slc4a1 Slc11a1 Slc30a5 Slc30a8 Slc7a11 Slc7a10 Slc7a6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Slc8a1 Slc8a2 Slc8a3 Slc5a5 Runx1 Cp Slc25a10 Slc17a5 Slc35a1 Slc38a1 Slc1a3 Slc1a2 Slc25a11 Slc30a1 Slco3a1 Slco1a4 Slco4a1 Slco1b2 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation Calm3 Ppp3ca Ppp3cb Nfatc1 Nfatc3 Nfatc2 Ppp3r1 ION HOMEOSTASIS%REACTOME%R-RNO-5578775.1 Ion homeostasis Slc8a1 Slc8a2 Atp1b1 Slc8a3 Atp1b3 Atp1b2 Ryr2 Ryr1 Prkaca Fkbp1b Dmpk Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Calm3 Trdn Ahcyl1 Pln Asph Trpc1 Nos1 Stim1 Tnni3 Itpr3 Itpr2 Itpr1 Atp2a1 Atp2a3 Atp2a2 Kcnj11 Abcc9 Camk2g Atp2b1 Camk2d Atp2b4 Atp2b3 Camk2b Sri Camk2a MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222397 MAPK3 (ERK1) activation Map2k1 Jak2 Tyk2 Ptpn11 Il6 Mapk3 Il6st Cdk1 Il6r BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 96%10222351 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Acadm Hadha Hadhb Echs1 Hadh Mecr MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy Map1lc3b Prkab2 Prkab1 Ube2d3 Ube2d2 Atg7 Tomm20 Src Prkn Usp30 Ube2l3 Pex5 Ube2n Atg3 Lamtor3 Mtmr14 Lamtor2 Rb1cc1 Uvrag Atg10 Atg13 Atg14 Tomm22 Chmp2b Atg5 Tbk1 Atg12 Gabarapl1 Mtmr3 Atg9a Pcnt Atg9b Atm Atg101 Chmp3 Pgam5 Tomm40 Chmp7 Ambra1 Chmp6 Wdr45b Wdr45 Arl13b Atg16l2 Mterf3 Atg16l1 Chmp4c Map1lc3a Pink1 Chmp4bl1 Fundc1 Tomm7 Wipi2 Wipi1 Atg4b Atg4c Nbr1 Atg4a Atg4d Csnk2a2 Csnk2a1 Park7 Csnk2b Sqstm1 Optn Rps27a Tsc2 Tsc1 Ulk1 Pik3c3 Chmp2a Gabarap Dync1h1 Uba52 Pik3r4 Dync1i2 Dync1i1 Gabarapl2 Ubb Ubc Mfn1 Mfn2 Rptor RragB Prkaa1 Prkaa2 Mtor Vdac2 Vdac3 Rheb Vdac1 Dync1li2 Becn1 Dync1li1 Tomm70 Slc38a9 Lamtor5 Dynll1 Lamtor4 Prkag3 Dynll2 Rraga Prkag1 Prkag2 Lamtor1 Rragc Rragd Mlst8 Cftr SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 96%10223771 Sodium Proton exchangers Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc9a9 Slc9a6 Slc9a7 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%R-RNO-1168372.1 Downstream signaling events of B Cell Receptor (BCR) Rasgrp1 Calm3 Psma4 Psma3 Psma6 Psma5 Psma2 Nras Psma1 Rps27a Psmd12 Psmd11 Kras Psmd14 Hras Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ikbkg Psmb1 Psmb3 Psmb2 Uba52 Nfkb1 Fbxw11 Btrc Psma7 Rela Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ppp3ca Ppp3cb Nfatc1 Ubb Nfatc3 Malt1 Nfatc2 Ubc Ppp3r1 Bcl10 Nfkbie Psmb6l1 Rel Psmd7 Nfkbib Psmd6 Psmd8 Fkbp1a Psmd2 Prkcb Psmd1 Adrm1 Cul1 Nfkbia Chuk FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions Cltb Cltc Dab2 Dnm1 Dnm2 Ap2m1 Gja1 Clta TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%10224317 Trafficking and processing of endosomal TLR Lgmn Tlr8 Tlr9 Hsp90b1 Cnpy3 Ctsk Ctsl Tlr7 Ctsb Ctss Unc93b1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222067 Proline catabolism Aldh4a1 Prodh Prodh2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation Pdpk1 ENSRNOG00000070986 Prkcq Cdc34 Ube2d2 Lyn Ikbkb Traf6 Ikbkg Map3k7 Ube2n Nfkb1 Fbxw11 Rela Malt1 Bcl10 Nfkbia Tab3 Tab2 Tab1 Chuk Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 ENSRNOG00000069193 AABR07065813.1 Skp1 ENSRNOG00000062915 Igll1 Psmb5 ENSRNOG00000065191 Psmb4 Ighl12 Psmb7 ENSRNOG00000062682 Psmb6 ENSRNOG00000070812 ENSRNOG00000070415 Psmb1 ENSRNOG00000070810 Psmb3 ENSRNOG00000066926 Psmb2 ENSRNOG00000066406 Uba52 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ube2d1 Btrc Iglc1 ENSRNOG00000070159 Psma7 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Psmc5 Psmc2 ENSRNOG00000066971 Psmc1 ENSRNOG00000063341 Psmc4 ENSRNOG00000065283 Psmc3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Ubb ENSRNOG00000067679 ENSRNOG00000070832 Ubc ENSRNOG00000064041 ENSRNOG00000064481 Psmb6l1 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Psmd7 ENSRNOG00000063713 ENSRNOG00000062820 Psmd6 ENSRNOG00000064886 Psmd8 ENSRNOG00000064490 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 Psmd1 ENSRNOG00000067603 Adrm1 Cul1 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 PHOSPHO-PLA2 PATHWAY%REACTOME%R-RNO-111995.1 phospho-PLA2 pathway Mapk1 Pla2g4a CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10224121 Chromatin organization Suz12 Eed Snrpepl2 Wdr77 Ctnnb1 Rbbp4 Rbbp7 Rbm17 Ddx46 Ddx42 Cdc73 Atf2 Chd8 Leo1 Nfkb2 Brwd1 Nfkb1 Rela Hdac2 Hdac10 Hdac8 Ncoa2 Ssrp1 Rcor1 Kdm4c Chd3 Chd4 Mbd2 Mta1 Mta2 Mta3 Mbd3 Cbx3 Kdm1a Gatad2a Gatad2b Hmg20b Tbl1x Hdac3 Tbl1xr1 Ncor2 Carm1 Gps2 Suds3 Brpf3 Kdm1b Kdm5b Coprs H2ac25 Prmt7 Dnmt3a Prmt3 Rps2 Ube2i Phf5a U2surp Skic8 Suv39h1 Snrpa1 H2ab2 Arid1a Arid1b Kmt5a H2ac4 Actl6a Actl6b Kdm4b Smarce1 Kdm4a Setd1b Setd1a ENSRNOG00000066901 Sf3a1 Sf3a2 Sumo1 Sf3a3 Sf3b1 Sf3b3 Ccnd1 Padi2 Sf3b4 Padi3 Sf3b5 Padi4 Nsd2 Padi1 Kmt2d Kat7 Padi6 Ehmt1 Kdm6b Kmt2a Kdm7a Kmt2b Phf2 Kmt2c H2ac18 Phf8 Ing4 Ing5 Setdb2 Ss18 Setdb1 Dpf1 Brd1 Pax3 Bicral Dot1l Bicra Dpf2 Setd3 Dpf3 Nsd3 Pbrm1 Setd2 Brd9 Prmt6 Setd7 Brd7 Hist1h2bq Setd6 Actg1 Ss18l1 Prmt1 Nsd1 Ash1l Smarcb1 Bcl7a Riox2 Hdac1 Bcl7b Suv39h2 Wdr5 Bcl7c Bcl11a Ash2l Mecom Smyd2 Bcl11b Smyd3 Brms1 Phf10 Aebp2 H2aj Kmt5b Snrpn Hat1 Atf7ip Jade1 Cherp Jade2 Smarca2 Jade3 Smarca4 Brpf1 H3-3b Kat6b Kat6a Prdm16 Hist3h2ba Sap30l Kdm4d ENSRNOG00000068602 Meaf6 Arid5b Uty Smarcd1 Msl2 Msl3 Smarcd3 Kdm5c Msl1 Smarcd2 Kdm5a Kat8 Kdm6a H2bc18 Arid4b Arid4a Jmjd6 H2az2 Kdm2b Rbbp5 H2bc4 Rest Kmt5c Hist1h4m H2bc1 Kdm3b Kdm3a Prdm9 Smarcc1 Hist1h2ai Puf60 Phf20 Hcfc1 Sap18 Kansl3 Kansl1 Kansl2 Smndc1 Mcrs1 Snrpf Ogt Snrpg Snrpb Nr2c2 Fam124b Zmynd8 Prmt5 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp Cbx1 Ctr9 Paf1 Phf6 Zfp592 Ctcf Cdk2ap1 Snrpd1 Nr2f2 Chd1 Chd2 Chd5 Chd6 Chd7 Tcf19 Cdk4 Dhx15 Pwwp2a Ezh2 Snrpd3 Mbd3l1 Mbd3l2 Zfp687 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Phc1 Smarcc1 Cbx4 Cbfb Cbx2 Phc3 Csnk2a2 Csnk2a1 Bmi1 Pbrm1 Smarcb1 Yaf2 Csnk2b Smarca2 Arid1a Smarca4 Arid1b Ep300 Rnf2 Actl6a Smarcd1 Actl6b Smarce1 Smarcd3 Pcgf5 Smarcd2 Ring1 Runx1 Phc2 Cbx6 EXTENSION OF TELOMERES%REACTOME%R-RNO-180786.1 Extension of Telomeres Terf2 Acd Terf1 Terf2ip Tinf2 Pot1 Ccna1 Ccna2 Ppp6r3 Chtf8 Ppp6c Blm Wrn Chtf18 Tert Ctc1 Stn1 Ten1 Dscc1 Dna2 Shq1 Dkc1 Nhp2 Pif1 Gar1 Wrap53 Rtel1 Nop10 Rpa1 Ankrd28 Rpa2 Rpa3 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Cdk2 Pola1 Pold4 Pold3 Prim2 Prim1 RIBAVIRIN ADME%REACTOME%R-RNO-9755088.1 Ribavirin ADME Itpa Pnp Nme2 Slc28a3 Slc28a2 Adk Nme1 Ada Slc29a3 Slc29a1 Nt5c2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%10222597 Activation of BH3-only proteins Ywhag Ywhae Bcl2l11 Ppp3cc Pmaip1 Dynll1 Dynll2 Bad Bmf Ywhaq Ywhah Sfn Ywhab Ppp3r1 Mapk8 Ywhaz AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222043 Amino acid and derivative metabolism Gpt2 Mtr Kmo Acad8 Carns1 Sirt5 Naalad2 Cps1 Qdpr Hibadh Azin2 Psph Rimkla Rimklb Tat Amd1 Asns Aldh7a1 Crat Nat8l Bcat1 Bcat2 Hibch Smox Sat1 Pcbd1 Carnmt1 Bckdhb Dct Pipox Bckdha Crym Gls2 Psat1 Srm Il4i1 Srr Aspg Hao1 Nags Aspa Bckdk Tmlhe Uroc1 Dao Chdh Ftcd Kynu Sardh Ppm1k Echs1 Ddo Agxt Otc Cbs Cth Phykpl Txnrd1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Shmt1 Psmb7 Psmb6 Psmb1 Psmb3 Slc44a1 Psmb2 Slc44a2 Mccc1 Gcsh Mccc2 Psma7 Dbt Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Slc22a4 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Dld Psmd1 Adrm1 Sephs2 Gstz1 Gamt Ckmt1 Ckmt2 Gatm Slc6a8 Ckm Slc6a12 Ckb Odc1 Oaz1 Oaz3 Oaz2 Nqo1 Azin1 Slc6a7 Slc6a11 Rida Sds Slc36a4 Sdsl Slc3a2 Cga AC132020.1 Ogdh Dlst Kgd4 Slc7a5 Prodh Glyat Tshb Aanat Scly Tph2 Mat1a Duox1 Tph1 Grhpr Aldh4a1 Ddc Pnmt Got2 Duoxa1 Amt Gnmt Duoxa2 Cav1 Agxt2 Prodh2 Asmt Txndc11 Dio1 Dio2 Dio3 Dbh Duox2 Tpo Th Mpst Iyd Usf1 Slc5a5 Sqor Ethe1 Fmo1 Mri1 Suox Ado Txn2 Bhmt Mtap Enoph1 Tst Adi1 Bhmt2 Gadl1 Cdo1 Slc25a10 Gls Dmgdh Tdo2 Tyrp1 Ido2 Hpd Ido1 Slc45a2 Pycr3 Pycr2 Pycr1 Glud1 Aldh6a1 Kyat1 Dhtkd1 Asl Tyr Hal Hykk Pah Acadsb Glul Gpt Phgdh Auh Aadat Agmat Slc25a21 Gcdh Folh1 Arg2 Got1 Arg1 Slc25a15 Ivd Slc25a12 Aass Slc25a13 Oca2 Oat Hdc Bbox1 Aoc1 Fah Asrgl1 Slc25a2 Amdhd1 Aldh9a1 Hsd17b10 Acat1 Ahcy Serinc4 Serinc5 Mtrr Serinc2 Aldh18a1 Hgd Serinc1 Haao MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10222827 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 TCR SIGNALING%REACTOME%R-RNO-202403.1 TCR signaling Pdpk1 Prkcq Plcg1 Csk Cdc34 Ube2d2 Inpp5d Pik3ca Pak1 Pak3 Psma4 Pak2 Psma3 Cd101 Pag1 Psma6 Pik3r1 Ptprc Psma5 Pik3cb Fyb1 Psma2 Psma1 Rps27a Pik3r2 Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Lcp2 Psmb5 Psmb4 Traf6 Psmb7 Psmb6 Ikbkg Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Uba52 Nfkb1 Pten Ube2d1 Fbxw11 Btrc Nck1 Psma7 Zap70 Rela RT1-Db2 Cd3g Psmc5 Cd247 Psmc2 RT1-Db1 Psmc1 Cd3e Psmc4 Cd3d Psmc3 Trav19 AC109737.1 Cd4 RT1-Ha Trat1 Lck Ptpn22 Itk RT1-Ba RT1-Bb Plcg2 Ubb ENSRNOG00000065955 Malt1 Ubc Trbv16 Bcl10 RT1-Da Ripk2 Grap2 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Nfkbia Tab2 Chuk Lat RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 96%10225099 RUNX1 regulates transcription of genes involved in BCR signaling Cbfb Pax5 Elf2 Runx1 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223469 ABC-family protein mediated transport Os9 Abcc1 Rnf5 Abcc2 Sel1l Abcc3 Abcb1 Psma4 Psma3 Psma6 Apoa1 Psma5 Kcnj11 Psma2 Abcf1 Psma1 Abcb6 Abcc9 Rps27a Abcb7 Psmd12 Abcb4 Psmd11 Abcb5 Abcb8 Psmd14 Abcb9 Psmd13 Abcg4 Abcg8 Eif2s3 Abcg5 Abcc5 Abcc6 Eif2s2 Abca12 Abcc10 Eif2s1 Psmb5 Abca2 Psmb4 Pex3 Abca5 Psmb7 Abca6 Psmb6 Abca9 Abca7 Psmb1 Abca8 Psmb3 Psmb2 Uba52 Abcd1 Abcd2 Abcd3 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Abca3 Pex19 Ubb Ubc Abcc4 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Derl3 Psmd2 Derl2 Psmd1 Adrm1 Erlin2 Erlin1 Vcp Erlec1 Cftr NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 96%10223189 NFG and proNGF binds to p75NTR Ngfr Ngf SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) Ppp2cb Ppp2ca Frs2 Ntrk1 Ngf Ppp2r5d Creb1 Pik3ca Shc1 Braf Ppp2r1b Ppp2r1a Mapk3 Crkl Pik3r1 Rapgef1 Rhoa Rps6ka5 Pik3cb Nras Chd4 Pik3r2 Grb2 Rap1a Kras Sos1 Hras Atf1 Mapk7 Irs2 Nab2 Dnal4 Egr2 Vrk3 Sgk1 Map2k2 Rps6ka3 Map2k1 Rps6ka1 Irs1 Rps6ka2 Dusp3 Ap2m1 Srf Dusp4 Clta Dusp7 Cltc Dusp6 Shc3 Shc2 Mapkapk3 Mapk14 Mapkapk2 Ap2s1 Mapk1 Ralgds Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Mapk11 Ywhab Crk Kidins220 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism Tymp Upb1 Upp1 Nt5c3a Nt5c Upp2 Nt5c1a Dpys Dpyd Nt5e Nt5m METAL ION SLC TRANSPORTERS%REACTOME%R-RNO-425410.1 Metal ion SLC transporters Slc8a1 Slc30a10 Slc8a2 Slc40a1 Slc8a3 Heph Slc8b1 Slc41a2 Slc41a1 Slc11a1 Calm3 Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc11a2 Slc9a9 Slc9a6 Slc9a7 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc39a8 Slc30a5 Slc39a7 Slc30a8 Slc39a6 Slc39a14 Slc24a5 Slc31a1 Slc24a4 Slc24a3 Slc30a1 Slc24a2 Slc24a1 Sri Cp SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse Rhoc Erbb2 Rnd1 Rhob Arhgef11 Rock2 Sema4d Rock1 Rhoa Arhgef12 Plxnb1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability Pdpk1 Ctnnb1 Rictor Ctnna1 Prr5 Jup Trib3 Calm3 Ctnnd1 Mapkap1 Them4 Pak1 Rac1 Cav1 Pak3 Mtor Pak2 Akt3 Akt2 Akt1 Hsp90aa1 Vav3 Nos3 Vav1 Vav2 Mlst8 DRUG ADME%REACTOME%R-RNO-9748784.1 Drug ADME Itpa Slco2b1 Gsta5 Gsta6 Gsta3 Sult1a1 Gsta1 Gsta2 Akr1c18 Abcg2 Abcc1 Akr1c12l1 Akr1c19 Abcc2 Sult2a2 Ugt1a2 Ugt1a1 Ugt1a3 Sult2a1 Ugt1a5 Sult2a6 Akr1c21 Abcb1 Ugt2b1 Hsd11b1 Cndp2 Hsd11b2 Ugt2b7 AC114845.1 Ugt2b34l1 Ggt1 Ugt2b Ggt5 Serpina6 Ggt7 Akr1c3l1 Akr1c12 Ggt6 Akr1c1 Akr1c13 Alb Gstp1 Ugt2b17 Ugt2b37 Ugt2b15 Gstt1 Akr1c9 Pnp Adk Hprt1 Ada Slc22a2 Slc22a1 Abcc5 Ugt1a6 Ugt1a7 Ugt1a8 Nat1 Nat2 Nat3 Ugt2a1 Ugt2a3 Gmps Ces2h Pon3 Impdh2 Pon1 Acy1a Impdh1 Ugt3a1 Bche Slc22a3 Xdh Bsg Ces1d Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Abcc3 Rac1 Vav3 Nme2 Vav1 Vav2 Nme1 Cyp3a9 Cyp3a18 Adh1 Cyp2c66 Cyp2e1 Cyp2c11 Slc22a7 Cyp3a1 Cyp2d4 Cyp3a62 Cyp3a2 Abcc4 Slc16a1 Slc28a3 Slc28a2 Tpmt Slco1a4 Slc29a3 Slc29a2 Slco1b2 Sult1e1 Slc29a1 Nt5c2 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME DATABASE ID RELEASE 96%10225197 Biosynthesis of E-series 18(S)-resolvins Gpx4 Hpgd Alox5 Lta4h Alox15 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%10225531 CHD3, CHD4, CHD5 subfamily Rbbp4 Rbbp7 H2ac18 Hist1h2bq Hdac1 H2aj H3-3b Hist3h2ba ENSRNOG00000068602 Chd3 Chd4 Mbd2 Mta1 H2bc18 Mta2 Mta3 Mbd3 H2az2 Cbx3 H2bc4 Hist1h4m H2bc1 Gatad2a Gatad2b Hist1h2ai Ube2i Hdac2 Nr2c2 H2ab2 Zmynd8 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp H2ac4 Cbx1 Phf6 Zfp592 Cdk2ap1 Nr2f2 Chd5 Tcf19 ENSRNOG00000066901 Pwwp2a Mbd3l1 Mbd3l2 Sumo1 Zfp687 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-RNO-1852241.1 Organelle biogenesis and maintenance Ywhag Sirt5 Sirt3 Rpgrip1l Ift140 Kif3a Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Wdr35 Dync2h1 Ift172 Wdr19 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Pcm1 Dynlrb2 Ssna1 Dynlrb1 Ift70b Tubg1 Ift81 Cep63 Dynlt2b Sstr3 Ift80 Cep152 Dynlt5 Tuba4a Dynlt2 Cycsl2 Haus4 Gabpa Haus5 Kif17 Haus6 Trip11 Pcnt Sfi1 Dync2i1 Dync2li1 Haus1 Dync2i2 Cluap1 Traf3ip1 Ift20 Cep250 Ift22 Idh2 Cep290 Cep78 Ift27 Cep76 Ift25 Cep72 Ift56 Acss2 Cep164 Cep70 Ift43 Cpap Cycs Tubb5 Ift46 Plk4 Ift74 Odf2 Ift70a2 Alms1 Sod2 Cetn2 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Pde6d Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Mchr1 Atp5mg Atp5f1b Atp5f1a Atp5po Hsp90aa1 Atp5mk Mt-atp8 Rab11a Kifap3 Kif3b Kif3c Nek2l1 Rho Ywhae Plk1 Cdk1 Rab3ip Actr1a Dctn1 Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Septin2 Kif24 Ttbk2 Tctn3 Fbf1 Tctn1 Akap9 Tctn2 Iqcb1 B9d1 Cep89 Ahi1 Nphp4 Cep83 Nphp1 Sclt1 Tmem216 Prkar2b Ppp2r1a Arf4 Cep97 Csnk1d Ccp110 Gbf1 Mkks Unc119b Arl13b Pkd1 Rp2 Asap1 Bbs9 Bbs7 Bbs5 Bbs4 Cct3 Cct2 Bbs10 Bbs12 Thoc2l Cngb1 Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Ttc8 Nphp3 Lztfl1 Pafah1b1 Dync1h1 Dync1i2 Tnpo1 B9d2 Nde1 Glud1 Clasp1 Smo Mapre1 Dynll1 Dynll2 Ckap5 Csnk1e TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars Slc35d1 Slc35b4 Slc35a1 Slc35a3 Slc35c1 Slc35a2 Slc35b3 Slc35b2 Slc35d2 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-RNO-9970672.1 FXIIa activates plasma kallikrein-kinin system Prcp Hist1h2ai F12 H2ab2 H3-3b Hist3h2ba A2m H2ac4 Hrg H2ac18 Klkb1 ENSRNOG00000068602 Plaur Kng1 H2bc18 Serping1 C1qbp Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2az1 H2bc1 Krt1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-RNO-205043.1 NRIF signals cell death from the nucleus Aph1b Itgb3bp Uba52 Ngf Sqstm1 Rps27a Psenen Ngfr Psen1 Psen2 Ubb Ncstn Ubc Aph1a Traf6 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-RNO-69560.1 Transcriptional activation of p53 responsive genes Zfp385a Tp53 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-RNO-3214841.1 PKMTs methylate histone lysines Prdm9 Suz12 Eed Nsd2 Nfkb2 Nfkb1 Kmt2d Ehmt1 Rbbp4 Kmt2a Rbbp7 Kmt2b Kmt2c Rela Setdb2 Setdb1 Dot1l Setd3 Nsd3 Setd2 Setd7 Setd6 Nsd1 Ash1l Suv39h2 Wdr5 Smyd2 Ash2l Mecom Suv39h1 Smyd3 Aebp2 Kmt5b Atf7ip Prdm16 Kmt5a Setd1b Setd1a H2bc18 Rbbp5 Ezh2 Kmt5c Hist1h4m TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation Ikbkg Nfkbib Nfkb2 Nfkb1 Ager Nfkbia Hmgb1l2 Rela Hmgb1l1 Nkiras1 App Chuk S100b Ikbkb Nkiras2 Hmgb1-ps34 GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Gja1 TRANSLATION%REACTOME%R-RNO-72766.1 Translation LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Ube2d3 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a LOC134480579 Rpl23a Mief1 Mtrf1l Trip4 Eif5 Mt-cyb Pelo Gfm1 Gfm2 Srp68 Mrrf Srp9 Mrps9 Mrps2 Mt-atp6 Mrps7 Mrps5 Mt-nd4l Tcf25 Srp54 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Psma4 Mrps31 Mrps33 Psma3 Mrps34 Mrps35 Mrpl43 Psma6 Mrpl44 Psma5 Mrpl45 Psma2 Mrpl46 Mt-atp8 Psma1 Mrpl48 Eef1d Rps27a Mtrf1 Eef1b2 Mrpl49 Eef1g Psmd12 Eef1a1 Mrps21 Psmd11 Mrps22 Rps14 Mrps23 Psmd14 Rps15 Mrps24 Psmd13 Rps16 Mrps25 Rps17 Mrps26 Rps15a Mrps27 Rps18 Malsu1 Rps19 Mrpl51 Pabpc1 Mrpl32 Psmb5 Rpsa Mrpl33 Rps10 Psmb4 Oxa1l Rps11 Psmb7 Mrpl34 Rps13 Psmb6 Mrpl35 Rps4x-ps13 Mrpl36 Psmb1 Mrpl37 Rps3a Rps27l Psmb3 Mrpl38 Psmb2 Rps9 Mrps10 Uba52 Rps7 Mrpl39 Rps8 Mrps12 Rps5 Chchd1 Ube2d1 Mrps15 Eif4h Rps26-ps13 Mrpl40 Ndufab1 Mrpl41 Eif3m Mrpl42 Eif3j Psma7 Mrpl21 Eif3i Mrpl22 Eif3l Mrpl23 Eif3k Mrpl24 Eif3f Psmc5 Mrpl27 Eif3e Psmc2 Mrpl28 Eif3h Psmc1 Srp14 Eif3g Psmc4 ENSRNOG00000068816 Eif3b Psmc3 Eral1 Eif3a Srp19 Eif3d Mrpl30 Eif3c Rps3 Mrpl10 Rps25 Mrpl11 Mrpl12 Rps4x Rps26 Mrpl13 Rps28 Ubb Mrpl14 Rps29 Mrpl15 Rps20 Ubc Mrpl16 Rps21 Mrpl17 Rps23 Mrpl18 Psmb6l1 Rps24 Ascc3 Eif1ax Ascc2 Eif4a2 Psmd7 Mrpl19 Eif4a1 Eif5b Psmd6 Fau Nemf Psmd8 Zfp598 Gadd45gip1 Psmd2 Mt-co3 Eif4ebp1 Mt-co2 Psmd1 Mrpl20 Mrpl3 Adrm1 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Klhdc10 Ptcd3 Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Rps6 Mt-nd3 Mt-nd2 Eif4e Ppa1 Ppa2 Eef2 Apeh Rps2 Eloc Elob Ltn1 AC132020.1 Kgd4 Cul2 Eif2b3 Eif2b2 Eif2s3 Eif2b5 Rpl4 Eif2b4 Rpl5 Eif2s2 Rpl3 Eif2b1 Rps27 Eif2s1 Rpl35 Rpl36 Rpl37 Rpl38 Rpl39 Rpl8 Rpl9 Rpl6 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rchy1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rbx1 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Hbs1l LOC100910714 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 96%10224139 Endosomal Vacuolar pathway RT1-M10-ps1 RT1-M10-ps5 RT1-M6-2 RT1-M1-5 AABR07044308.1 Rt1-ec3 RT1-M2 B2m RT1-N3 Lnpep RT1-M1-2 RT1-M5 PTK6 DOWN-REGULATION%REACTOME%R-RNO-8849472.1 PTK6 Down-Regulation Ptpn1 Srms Ptk6 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling Il27 Vamp7 Il23a Il12a Crlf1 Canx Jak2 Il23r Stat3 Stat1 P4hb Tyk2 Il12rb1 Il12rb2 Il6st Ebi3 Il12b GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-RNO-159854.1 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Pros1 F10 F7 F9 Ggcx Bglap Furin Gas6 F2 Proc Proz SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-RNO-1855204.1 Synthesis of IP3 and IP4 in the cytosol Itpk1 Pten Itpka Itpkc Itpkb Plcg1 Inpp5b Plch1 Pld4 Plcd1 Plcd4 Ocrl Inpp5j Plcd3 Calm3 Synj1 Plcz1 Plce1 Plcg2 Inpp5d Plcb4 Plcb3 Inppl1 Plcb2 Plcb1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222941 Classical antibody-mediated complement activation C1qb Crp C1qa C1s C1r C1qc ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-RNO-9623433.1 LXRs regulate gene expression to control bile acid homeostasis Ncor2 Nr1h3 Nr1h2 Rxrb Rxra METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals Mt2 Mt3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 96%10223481 Platelet degranulation Aldoa Serpina3n Timp3 Fam3c Serpinf2 Tln1 F13a1 Anxa5 Fn1 Calm3 Qsox1 Pdgfa Pdgfb Brpf3 Vegfa Lgals3bp Alb Vegfd Vegfc Lamp2 Vegfb Wdr1 Apoa1 Maged2 Kng1 Endod1 App Serpina4 F8 Actn2 Habp4 Cdc37l1 Serpina1 Tagln2 Cd36 Itih4 Itih3 Pros1 Cd109 Nhlrc2 Fermt3 Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Igf2 Igf1 Hgf Sparc Apoh Vcl Gtpbp2 Orm1 Ecm1 Tuba4a Ola1 Ctsw Psap Actn4 Ppbp Flna Tmsb4x Cd63 Tor4a Tgfb1 Tgfb2 Tgfb3 Fgb Fga Fgg Pcdh7 Tmx3 Itga2b Scg3 Selp Plg Cyrib Sccpdh Egf Srgn Serping1 Pecam1 Itgb3 Clu Actg1 Actn1 Aplp2 Timp1 Cyb5r1 Mmrn1 Cd9 Plek Sod1 A2m Tf Phactr2 Stxbp2 Vti1b Chid1 Abcc4 Cfd Pf4 A1bg Rab27b Serpine1 Islr Pcyox1l Hrg Lhfpl2 Gas6 Sytl4 Ly6g6f Ahsg Spp2 ICOS CO-STIMULATION%REACTOME%R-RNO-9927354.1 ICOS co-stimulation Pik3r5 Pik3cg Pik3r2 Pik3r3 Pik3ca Pik3cd Pik3r6 Icoslg Icos Pik3r1 Pik3cb ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%10224247 Acyl chain remodeling of CL Hadha Pla2g4a Hadhb Tafazzin Lclat1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-RNO-74160.1 Gene expression (Transcription) Ddx21 Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Gtf3a Crcp Polr3a Brf2 Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr3f Polr3g Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Lamtor3 Gtf3c5 Lamtor2 Bdp1 Ran Ywhab Gpx2 Wwox Txnrd1 Gsr Ccne1 Ccne2 Steap3 Tfdp2 Tfdp1 Rbl1 Rpa1 Rpa2 Rpa3 E2f4 E2f5 Cdkn1b Rptor RragB Ppm1a Mtor Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Lbr Rragc Rragd Stk11 Mlst8 Rnf111 Blm Wrn Dna2 Paxip1 Mre11 Ube2i Eloc Kat5 Elob Nbn Hus1 Atrip Baz1b Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Atm Atr Exo1 Rmi2 Rmi1 Brip1 Smarca5 Sumo1 Rhno1 Rad50 Ehmt1 Ing5 Setdb1 Brd1 Topbp1 Rbbp8 Brca1 Rad1 Smyd2 Aebp2 Atf7ip Brpf1 Kat6a Meaf6 Sfn Plk3 Prdm9 Rnf34 Phf20 Gls Gpi Cdc25c Mdm4 Ywhaq Ywhah Ywhaz Zfp385a Pdpk1 Ctnnb1 Men1 Sirt3 Gls2 Tcf7 Tcf7l1 Tcf7l2 Cdc73 Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Cstf2 Cstf3 Cstf2t Lsm10 Lsm11 Sympk Pabpn1 Clp1 Smurf2 Cpsf4 Cpsf6 Cpsf7 Lef1 Cpsf1 Cpsf2 Cpsf3 Leo1 Cavin1 Banp Slbp Txn Cycsl2 Cycs Psma4 Ccna1 Psma3 Polr1b Polr1a Ccna2 Polr1f Psma6 Polr1g Psma5 Polr1e Psma2 Polr1h Psma1 Chd3 Rps27a Chd4 Psmd12 Taf1d Psmd11 Rrn3 Taf1a Psmd14 Taf1c Psmd13 Taf1b Mta1 Mta2 Mta3 Nr1h3 Mbd3 Cbx3 Nr1h2 Ercc6 Psmb5 Ubtf Gatad2a Psmb4 Rxrb Gatad2b Psmb7 Rxra Psmb6 Ccnb1 Psmb1 Psmb3 Pgr Psmb2 Rxrg Uba52 Tbl1x Ube2d1 Psma7 Aurka Cited1 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Cdk9 Hdac3 Ubb Pou2f1 Tbl1xr1 Rara Ubc Foxo3 Psmb6l1 Npm1 Psmd7 Ppard Rb1 Psmd6 Psmd8 Psmd2 Mt-co3 Mt-co2 Psmd1 Ncor2 Adrm1 Gps2 Cdk2 Cdk1 Ncoa3 Rarg Mapk1 Mt-co1 Nr5a2 Notch4 Ppp2cb Ppp2ca Zfp839 Ddit4 Higd1c Cited4 Cited2 Zfp819 Plk2 Igfbp3 Phax Tmem219 Ell2 Ell3 Btg2 Zik1 Cdk5r1 Zfp867 Zfp866 Mtf2 Zfp612 Zim1 Zfp617 Zfp605 Zfp46 Zfp804b Ipo8 Rprd1a Rprd1b Supt6h Sesn2 Zfp418l1 Ppp2r1b Sesn1 Ppp2r1a Cnot11 Cdk5 Sesn3 Kdm5b Tfap2e Cnot10 Npas4 Tp53rkb Tp53rka Zfp52 Znf354c Znf354b Mybbp1a Znf354a Tnks1bp1 Zfp90 Zfp78 Zfp74 Tsn Maged1 LOC102546572 Zfp81 Skil Mterf1 Cox7a1 Cox7a2 Mllt3 Mllt1 Atp1b4 Zfp873l3 Ints4 Ints5 Ints6 Zfp398 Ints7 Ints8 Ints9 Cox7a2l Ints1 Ints2 Ints3 Zfp386 Cnot6l Zfp764l1 Ttf1 Rffl Zfp133 Znf382 Cradd Pidd1 Znf394 Tpx2 Tp63 Nabp1 Nabp2 Esrra Tp53 Esrrb Zfp273l-ps1 Esrrg Skic8 Ezhip Zfp180 Zfp189 Zfp184 Parp1 Ccng1 Tsnax Zfp169 H2ab2 LOC102547287 Arid1a Zfp94l1 Arid1b LOC108348267 Lmo2 Zfp455l1 Lmo3 Zfp790 Ccnh Zfp317 H2ac4 Zfp799 Serpinb13 Zfp300 Zfpm1 Actl6a Zfp786 Actl6b Zfp788 Smarce1 Rsl1 Gata3 Zfp770 Gata1 Znf773 Gata2 Zfp775 Setd1b Yeats4 Setd1a Morc2 Wwtr1 Ring1 Abl1 Zfp764 ENSRNOG00000066901 Zfp763 Tp73 Jmy Ccnd2 Zfp111 Phc2 Zfp113 Cbx6 Zfp597 Ccnd3 Znf750 Phc1 Tgif1 Cbx4 Tgif2 Sf3b1 Cbfb Zfp599 Ccnd1 Nr1d2 Cbx2 Nr1d1 Esr1 Zfp583 Phc3 Zfp101 Dyrk2 Kmt2d Ndufa4 Crebbp Cdk7 Iws1 Cdk6 Dek Trim33 Kmt2a Znf740 Kmt2b Zfp566 Kmt2c H2ac18 Zfp324 Bax Tcf3 Sin3a LOC120095871 Sin3b Nr1i3 Zfp954 Csnk2a2 Zfp951 Ctsk Zfp790l2 Ctsl Rnmt Zfp710 Csnk2a1 Zfp952 Srrt Bmi1 Mnat1 Znf18 Pbrm1 Zfp719 Brd7 Prdx2 Prmt6 Actg1 Prdx5 Hist1h2bq Zfp704 Prmt1 Zfp945 Smarcb1 Zfp703 Hdac1 Wdr5 Zfp706 Ash2l Zfp948 ENSRNOG00000070049 Yaf2 Csnk2b L3mbtl1 Pax5 Ezh1 H2aj Tp53bp2 Nrbf2 Elf1 Nrbf2l1 Elf2 Tal1 Tead4 Zfp758 Smarca2 Zscan25 Smarca4 Zscan22 Foxp3 Pou2f2 H3-3b Zfp746 Yap1 Hist3h2ba Krba1 Ep300 Pcgf6 Noc2l Rnf2 ENSRNOG00000068602 Tead3 Ski Itch Tead2 Smarcd1 Tcf12 Tigar Zfp964 Smarcd3 Pcgf5 Hipk1 Cox6a1 Smarcd2 Ptpn11 Cox6a2 Zfp286a H2bc18 Rabggta Runx1 Kat2b Rabggtb Ppp1r13l H2az2 Ppp1r13b Rbbp5 Zfp119bl H2bc4 Hist1h4m Max Jarid2 H2bc1 Pml Cox6c2 Cnot3 Smarcc1 Cnot2 Hist1h2ai Cnot1 Nek4 Cnot7 Cnot6 Cnot4 Rorc Cnot9 Rorb Cnot8 Ints13 Ints14 Cox6b1 Ints11 Cox6b2 Ints12 Ints10 Zc3h8 Rngtt Pphln1 Foxg1 Rprd2 Myo1c G6pdx Casp2 Mga Zfp37-ps1 Tbx5 E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 Nr6a1 Zfp496 Zfp808l3 Prkaa1 Pip4p1 Eaf1 Prkaa2 Eaf2 Zfp483 Cox8a Rpap2 Cox8c Zfp248 Nuak1 Hnf4a Cox7b Foxo1 Hnf4g Cox7c Prkag3 Zkscan8 Prkag1 Zkscan7 Prkag2 Zkscan1 Zkscan4 Zkscan5 Zkscan3 Bnip3l Nr4a3 Mapkapk5 Nr4a2 Ezh2 Zfp955a Zfp955b Bmal1 Nrif1 Ywhag Runx3 Suz12 Cox5a Cox5b Zfp12 Eed Zfp13 Gsk3b Zfp950l16 Zfp282 Ttc5 Nr2c1 Ice2 Kctd1 Rbbp4 Pou4f1 Rbbp7 Znf431l2 Pou4f2 Tasor Prkab2 Zfp668 Prkab1 Znf689 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Ssu72 Znf624l Ube2d3 Zfp641 Phf19 Zfp647 Znf667 Znf426 Aff4 Cox4i1 Tfb2m Cox4i2 Tfam Nr2f6 Polrmt Nr0b2 Nr0b1 Nr2f1 Nr2e3 Gadd45a Zfp212 Epop Zfp213 Zfp455 Tnrc6c LOC134478826 Mapk3 Rex2l4 Tnrc6a Tnrc6b Zfp445 Zfp688 Zfp950l5 Usp9x Map2k6 Kat2a Maml3 Rbpj Hdac2 Hdac5 Hdac4 Mapk14 Maml1 Hdac11 Maml2 Hdac10 Notch3 Hdac9 Hdac8 Mapk11 Cpap Tgfb1 Ncoa2 Furin Nr1h4 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Akt3 Akt2 Akt1 Mbd2 Tsc2 Tsc1 Cbx5 Prkra Ago4 Ago3 Ago2 Ago1 Dicer1 Tarbp2 Chm Ywhae Brpf3 Src Dnmt3a Atad2 Lhb Cga Rfc5 Rfc3 Rfc4 Pcna Rfc2 Kmt5a Sirt1 Sp1 Mphosph8 Med23 Med24 Med20 Tasp1 Akap8l Cxxc1 Kat8 Med27 Med12 Med1 Yeats2 Med13 Med14 Wdr82 Med10 Ccnc Med4 Pparg Med6 Kat14 Mbip Hcfc1 Med16 Med17 Hcfc2 Dr1 Kansl3 Kansl1 Kansl2 Phf20l1 Ajuba Bod1l1 Pagr1 Tada3 Med30 Tada2a Med31 Ppargc1a Ppargc1b Mcrs1 Zzz3 Sgf29 Psip1 Snrpf Ogt Snrpg Snrpb Nr2c2 Prmt5 Ctr9 Paf1 Smurf1 Snrpd3 Snrpepl2 Arnt2 Arnt Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Ncbp2 Ncbp1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Myc Ar Foxo4 Atxn3 Usp2 Usp7 Smad2 Smad3 Smad4 Smad7 Suv39h1 Rrp8 Nr1i2 Nr3c2 Nr3c1 Vdr Dnmt1 L3mbtl2 Daxx Ing2 Ppara Trim28 Pcgf2 Thrb Thra Nr5a1 Prdx1 Taf9 Taf9b Tfap2c Tfap2a Taf15 Tfap2b Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Tdg Taf4 Taf2 Taf1 Gtf2e2 Pip4k2b Pip4k2c Pip4k2a Foxo6 Sgk1 Nr4a1 Rictor Prr5 Mapkap1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines Stat6 Sting1 Tbk1 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport Cygb Mb Ngb SERINE METABOLISM%REACTOME%R-RNO-977347.1 Serine metabolism Phgdh Serinc4 Serinc5 Psph Serinc2 Psat1 Sds Serinc1 Sdsl Srr FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223703 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Plcb3 Gna11 Gna14 Plcb2 Plcb1 Ffar1 Gnaq CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-RNO-446353.1 Cell-extracellular matrix interactions Arhgef6 Pxn Fblim1 Parvb Parva Ilk Fermt2 Flna Flnc Vasp Itgb1 Actn1 Tesk1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-RNO-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Ikbkg Map3k7 Ube2n Aim2 Birc2 Mapk12 Aamp Nod2 Casp2 Nod1 Casp9 Map2k6 Pycard Panx1 Txnip Ripk2 Sugt1 Nlrp3 Txn Casp1 Mefv Casp8 Pstpip1 Nlrp1a Hsp90ab1 Mapk14 P2rx7 Cyld Itch Tab3 Tab2 Mapk13 Tab1 Bcl2l1 Mapk11 Traf6 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%10223285 TNFR2 non-canonical NF-kB pathway Birc2 Uba3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Tnfsf13 Psmd12 Psmd11 Psmd14 Eda Psmd13 Tnfrsf4 Tnfrsf8 Tnfrsf1b Edar Tnfrsf11b Skp1 Tnfrsf11a Cd40lg Psmb5 Tnfsf4 Psmb4 Psmb7 Cd40 Tnfsf13b Psmb6 Tnfsf11 Psmb1 Tnfsf8 Psmb3 Tnfsf9 Psmb2 Relb Uba52 Tnfrsf9 Nfkb2 Lta Ltb Traf2 Tnfrsf17 Edaradd Tnf Fbxw11 Tnfsf15 Btrc Tnfsf14 Tnfrsf1a Psma7 Tnfsf12 Tnfrsf13c Tnfsf18 Ltbr Psmc5 Tnfrsf25 Ube2m Psmc2 Eda2r Psmc1 Tnfrsf18 Psmc4 Tnfrsf12a Psmc3 Map3k14 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Traf3 Chuk INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223463 Intestinal lipid absorption Npc1l1 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism Pdp1 Pdpr Pdp2 Uba52 Pkml1 Pdha1 Pdha2 Ranbp9 Ldhal6b Glo1 Wdr26 Hagh Nek1 Ubb Mkln1 Fahd1 Ubc Gid4 Maea Ldha Gpt Ldhb Ldhc Armc8 Me1 Me3 Me2 Rmnd5b Dld Pdhx Pgam5 Vdac1 Rps27a Pc Pdk4 Pdk3 Dlat Pdk2 Pdk1 Pklr Pdhb Gstz1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%10222929 Signalling to RAS Shc3 Shc1 Mapkapk3 Shc2 Mapk14 Mapkapk2 Nras Ralgds Grb2 Kras Sos1 Hras Mapk11 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-RNO-202131.1 Metabolism of nitric oxide: NOS3 activation and regulation Zdhhc21 Cav1 Ddah1 Nostrin Cyb5b Akt1 Nosip Spr Lypla1 Hsp90aa1 Nos3 Cygb Dnm2 Calm3 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%10222193 Caspase activation via extrinsic apoptotic signalling pathway Casp8 Traf2 Dcc Appl1 Tradd Cflar Ripk1 Tnfsf10 Fas Fadd Casp3 Faslg Casp9 Ly96 Ticam2 Ticam1 Cd14 Tlr4 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10225481 Complex IV assembly Mt-co2 Cox18 Tmem177 Cox20 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%10223423 Apoptosis induced DNA fragmentation Hmgb1l2 Hmgb1l1 H1-1 H1-0 H1-5 H1-4 H4f3 Hmgb2 Dffa Casp3 Dffb Kpnb1 Hmgb1-ps34 Kpna1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 96%10222555 G alpha (12 13) signalling events Rhoc Adra1b Adra1a Adra1d Arhgef7 Rock2 Rock1 Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Rhoa Arhgef10 Arhgef12 Ngef Arhgef19 Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Plxnb1 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Rhob Tbxa2r Btk Rasgrf2 Gna12 Mcf2 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224473 Syndecan interactions Itga2 Prkca Sdc1 Fgf2 Itgb1 Itga6 Sdc4 Itgb3 Sdc3 Itgb4 Sdc2 Itgav Vtn Tgfb1 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates Mre11 Slx4 Eme2 Kat5 Spidr Eme1 Rad51 Rad50 Nbn Gen1 Rad51c Rad51b Rbbp8 Brca2 Brca1 Rad51ap1 Bard1 Top3a Palb2 Firrm Xrcc3 Slx1b Xrcc2 Atm Exo1 Mus81 Rmi2 Fignl1 Rmi1 Blm Brip1 Wrn Dna2 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins Phc1 Nup133 Suz12 Sumo3 Cbx4 Nup210 Nup155 Nup153 Cbx2 Phc3 L3mbtl2 Pcgf2 Bmi1 Satb2 Satb1 Hdac1 Sumo2 Rnf2 Hist1h4m Ube2i Nup93 Nup50 Nup35 Nup54 Nup98 Hdac2 Nup58 Nup37 Hdac4 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Pias1 Nup62 Pias2 Nup43 Ring1 Nup88 Aaas Ranbp2 Phc2 Sumo1 Nup214 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins Pros1 F10 F7 F9 Bglap Furin Gas6 F2 Proc Proz G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222897 G2 M DNA replication checkpoint Ccnb1 Pkmyt1 Ccnb2-ps2 Ccna1 Wee1 Ccna2 Ccnb2 Cdk1 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-RNO-9909505.1 Modulation of host responses by IFN-stimulated genes Ikbkg Ube2l6 Isg15 Fkbp5 Chuk Arih1 Ifi44 Ifi44l Ikbkb Rig1 Trim25 Uba7 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223787 Inorganic anion exchange by SLC26 transporters Slc26a11 Slc26a6 Slc26a4 Slc26a3 Slc26a9 Slc26a2 Slc26a1 Slc26a7 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 96%10225063 CREB3 factors activate genes Mbtps1 Creb3l3 Crebrf REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-RNO-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins Hist1h2ai Cbx5 Znf431l2 Zfp324 H2ac18 LOC120095871 Setdb1 ENSRNOG00000065205 Trim28 Znf382 Znf624l Zfp719 Zfp867 Hist1h2bq ENSRNOG00000070049 H2aj Zfp808l3 Atf7ip H2ab2 Zfp758 H3-3b Rex2l4 Hist3h2ba Zfp317 H2ac4 ENSRNOG00000068602 Zfp52 Zfp950l5 Zfp964 Znf354a H2bc18 ENSRNOG00000066901 H2az2 LOC102546572 H2bc4 Hist1h4m H2bc1 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 96%10224713 Intraflagellar transport Kifap3 Kif3b Tnpo1 Kif3c Ift140 Kif3a Ift52 Dynlrb2 Ttc21b Dynlrb1 Ift57 Ift70b Ift122 Ift81 Dynlt2b Ift80 Dynlt5 Wdr35 Dync2h1 Dynlt2 Ift172 Wdr19 Kif17 Trip11 Dync2i1 Dync2li1 Dync2i2 Cluap1 Traf3ip1 Ift20 Dynll1 Ift22 Dynll2 Ift27 Ift25 Ift56 Ift43 Ift46 Ift74 Ift70a2 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-RNO-173599.1 Formation of the active cofactor, UDP-glucuronate Slc35d1 Uxs1 Ugp2 Ugdh G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224093 G protein gated Potassium channels Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-5651801.1 PCNA-Dependent Long Patch Base Excision Repair Polb Fen1 Pole Rfc5 Pold2 Apex1 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pold3 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%10225477 PDH complex synthesizes acetyl-CoA from PYR Dlat Dld Pdhx Pdha1 Pdhb Pdha2 G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Grk2 Gnal Gnaq Gnat3 Prkar2a Prkar2b Pde1b Pde1c Pde1a Plcb4 Plcb3 Mapk1 Pla2g4a Plcb2 Plcb1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 DIGESTION%REACTOME DATABASE ID RELEASE 96%10223083 Digestion Cel Pnliprp2 Pnliprp1 Gucy2c Si Lipf Pir Amy2 Alpi Guca2b Guca2a Lct Clps Chia Pnlip Chit1 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 96%10225499 Regulation of PD-L1(CD274) Post-translational modification Ywhag Ddost Ccnd1 Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Mib2 Pdcd1lg2 Prkab2 Prkab1 Csnk2a2 Csnk2a1 Csnk2b Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Erlec1 B3gnt3 Dad1 ATORVASTATIN ADME%REACTOME%R-RNO-9754706.1 Atorvastatin ADME Slco2b1 Cyp3a9 Abcc2 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Abcb1 Cyp3a1 Cyp3a62 Cyp3a2 Pon3 Pon1 Slco1b2 ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins Defa Prss2 Prss3 Try10 Prss2l1 Prss1 Art1 Np4 Defa24 Try5 Defa9 LOC102554637 Defal1 Defa8 Cd4 Defa6 Defa3 Defa31 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223393 Catecholamine biosynthesis Ddc Pnmt Dbh Th VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223127 Vesicle-mediated transport Ereg Btc Galnt1 Galnt2 Spta1 Sptb Sptbn1 Sptbn2 Hbegf Sptan1 Sptbn5 Sptbn4 Grb2 Vamp2 App Tgfa Areg Scarb1 Cd36 Tjp1 S100a9 Il7r Hmgb1-ps34 Egfr Chmp2b Chmp3 Hmgb1l2 Hmgb1l1 Kif4b Chmp7 Ap2s1 Chmp6 Kif4a Vps4a Chmp4c Dnm3 Ap2a2 Chmp4bl1 Ap2a1 Ap2b1 Sh3gl2 Alpi Cyth2 Cyth3 Cyth4 Vps36 Cyth1 Slc18a3 Bnip1 Egf Vps25 Vps28 Bin1 Hpx Synj1 Bloc1s3 Kif18b Bloc1s4 Kif19 Bloc1s6 Kif26b Snf8 Kifc1 Snap29 Kifc2 Snx18 Kif26a Ubap1 Ston1 Ston2 Eps15l1 Kif11 ENSRNOG00000062839 Kif12 Tor1a Tor1b Kif15 Nbas Rab36 Kif5a Hp Kif5b Rab3il1 Tpd52 Kif21a Madd Scarb2 Kif1c Akt3 Ldlr Akt2 Snapin Kif21b Akt1 Cd163 Kif13b Cops3 Kif1a Sbf2 Cops6 Kif1b Sbf1 Optn Cops8 Kif6 Rab11b Aak1 Rab11a Synj2 Rab31 Tbc1d8b Rab35 Syt11 Tf Kif9 Rab38 Ambp Sh3gl3 Tsc2 Sh3kbp1 Tsc1 Tfrc Rab3gap2 Tpd52l1 Rab3gap1 Vps4b Dennd1a Dtnbp1 Kif22 Dnajc6 Clvs1 Rab1b Sh3gl1 Kif23 Dnase2 Fnbp1l Ulk1 Clvs2 Dennd1b Rint1 Kif28 Trappc2l Pik3c2a Fth1-ps5 Kif27 Ap4b1 Dennd1c Bicd2 Ap1b1 Kif16b Chmp2a Bicd1 Rin3 Kif20a Gabarap Klc1 Ap1m2 Agpat3 Vamp7 Fcho1 Rin1 Kif20b Bloc1s1 Fcho2 Rin2 Ap1m1 Pafah1b3 Mon1b Kifap3 Vamp8 Pafah1b2 Dennd6a Ap4s1 Fth1 Mon1a Ap1s3 Klc4 Mvb12a Dennd6b Ap1s2 Rab5a Mvb12b Rab4a Klc3 Necap2 Txndc5 Trappc10 Klc2 Necap1 Ap1g2 Vps37a Ap1g1 Rabgap1 Rab33b Vps37b Ap4m1 Rab33a Vps37c Kif3b Hspa8 Tbc1d2 Vps37d Ap4e1 Hps1 Hip1r Tbc1d7 Agfg1 Kif3c Gabarapl2 Vps45 Snx2 Snx9 Ccz1 Hps4 Snx5 Trappc12 Pum1 Trappc11 Cops7a Trappc13 Cops7b Rab3a Hip1 Rinl Tsg101 Gapvd1 Ftl1 Als2cl Gak Gdi1 Stx18 Rabgef1 Yipf6 Gdi2 Stab1 Chm Pla2g6 Rab7a Pacsin1 Rab7b Pacsin3 Pacsin2 Dennd4c Sort1 Dennd4a Ap3b1 Dennd4b Sh3d19 Ywhae Rab27a Grk3 Rab39a Amph Tbc1d14 Snap91 Rab27b Syt2 Tbc1d13 Syt9 Tbc1d16 Acbd3 Tbc1d15 Syt8 Tbc1d17 Use1 Trappc6b Akp3 Trappc6a Alpp Trappc9 Alpg Trappc8 Ubqln2 Tbc1d10c Chmp5 Trappc5 Ubqln1 Trappc4 Epn2 Trappc3 Epn1 Dennd5a Reps1 Trappc2 Reps2 Tbc1d10b Trappc1 Rab6b Tbc1d10a Rab6a Rab5c Rab5b Dennd5b Stx4 Als2 Golga4 Rab3ip Sytl1 Rab43 Tbc1d25 Tmf1 Tbc1d24 Sys1 Arf6 Golga1 Map1lc3b Vps51 Rab21 Vps52 Chml Vps54 Arl1 Rab9a Gcc2 Rab9b Gcc1 Dennd2a Rab1A Usp6nl Stx6 Dennd2c Ric1 Ttgn1 Rab10 Igf2r Scoc Rab13 M6pr Rab12 Vti1a Rab14 Vamp3 Rab18 Vamp4 Rab8b Stx16 Rab8a Arfip2 Rgp1 Rhobtb3 Ankrd27 Rabepk Dennd3 Arfrp1 Snap23 Slc2a8 Src Gria1 Msr1 Calr Arrb2 Arrb1 Cd3g Cd3d Cd4 Sparc Ctsz Jchain Pip5k1c LOC120093819 Pafah1b1 Zw10 Apol7al1 Kif18a Apol2 Dync1h1 Apol7bl1 Dync1i2 Dync1i1 Cenpe Apol9a Sec13 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Dynll1 Dynll2 Wnt5a Alb Kif3a Itsn2 Dvl2 Fzd4 Apoa1 Sar1b Gps1 Apoe Apob Trip10 Lrp1 Lrp2 Cops4 Arpc3 Cops2 Arpc2 Cpd Arpc5 Arpc4 Picalm Eps15 Dnm2 Avpr2 Trip11 Actr2 Arpc1a Actr3 Gns Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Racgap1 Ocrl Fnbp1 Rps27a Agtr1 Ldlrap1 Uba52 Avp Ubb Ubc Pla2g4a Stam Cftr Ins1 Cd55 Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Adrb2 Cog6 Cog7 Nedd8 Cog8 Napa Nsf Napb Ank1 Grk2 Napg Sec23a Tmem115 Tacr1 Kdelr2 Kdelr3 Sec23ip Sec16b Hgs Sec16a Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Stam2 Tmed10 Tmed9 Copb1 Cope Golgb1 Chrm2 Col7a1 Ppp6c Sec31b Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Hba1 Stx5 Hbb Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Syt1 Hsp90b1 Prdx1 Itsn1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Ap2m1 ENSRNOG00000070832 Gja1 ENSRNOG00000064041 Clta ENSRNOG00000064481 Cltb ENSRNOG00000065690 Myo6 ENSRNOG00000064085 ENSRNOG00000066904 Cltc ENSRNOG00000063713 Dab2 ENSRNOG00000062820 Dnm1 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Cbl Cops5 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 96%10222285 Carnitine shuttle Ppard Slc22a5 Prkag2 Cpt1a Mid1ip1 Prkaa2 Thrsp Cpt2 Cpt1b Slc25a20 Rxra Prkab2 FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization Izumo1 Cd9 Hyal5 Catsperg Catsperd Catsper4 Catsper2 Catsperb Hvcn1 Catsper3 Catsper1 Kcnu1 Acr Izumo4 Izumo3 Izumo2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%10224617 WNT5A-dependent internalization of FZD4 Cltb Dvl2 Cltc Arrb2 Prkcb Fzd4 Prkcg Wnt5a Ap2s1 Prkca Ap2a2 Ap2a1 Ap2b1 Ap2m1 Clta GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Kcnb1 Kcns3 Kcnc2 Kcng2 Prkaca Prkacb Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Itpr3 Rapgef4 Itpr2 Rapgef3 Itpr1 Gcg Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Glp1r Gng11 Rap1a Gng10-ps1 Gnas ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-6807062.1 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Srebf1 Nsdhl Dhcr24 Tm7sf2 Srebf2 Hsd17b7 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-RNO-73943.1 Reversal of alkylation damage by DNA dioxygenases Alkbh5 Fto SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Casp7 Diablol1 Xiap FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190374.1 FGFR1c and Klotho ligand binding and activation Kl Fgf23 Fgfr1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%10224579 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Rb1 Ep400 Asf1a Cabin1 Hira Ubn1 Hmga2 H1-1 Hmga1 H1-0 H1-5 H1-4 H4f3 Lmnb1 Tp53 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%10225361 Sensory perception of sweet, bitter, and umami (glutamate) taste Tas2r16 Tas2r13 Gnat3 Itpr3 Tas2r136 Tas2r140 Gnb1 Tas2r105 Tas2r107 Gnb3 Tas1r2 Tas2r119 Tas1r1 Tas2r120 Tas2r39 Tas1r3 Tas2r4 Tas2r38 Tas2r3 Tas2r40 Tas2r41 Tas2r7 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-RNO-212436.1 Generic Transcription Pathway Runx3 Ywhag Suz12 Cox5a Cox5b Zfp12 Eed Zfp13 Zfp950l16 Zfp282 Ttc5 Nr2c1 Kctd1 Rbbp4 Pou4f1 Rbbp7 Znf431l2 Pou4f2 Zfp668 Prkab2 Znf689 Prkab1 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Znf624l Ube2d3 Zfp641 Zfp647 Znf667 Znf426 Cox4i1 Cox4i2 Nr2f6 Nr0b2 Nr0b1 Nr2f1 Nr2e3 Gadd45a Zfp212 Zfp213 Zfp455 LOC134478826 Mapk3 Rex2l4 Zfp445 Zfp688 Zfp950l5 Usp9x Map2k6 Lamtor3 Kat2a Lamtor2 Maml3 Rbpj Hdac2 Hdac5 Hdac4 Maml1 Mapk14 Hdac11 Maml2 Hdac10 Notch3 Hdac9 Hdac8 Cpap Mapk11 Ywhab Gpx2 Tgfb1 Wwox Furin Nr1h4 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Txnrd1 Akt3 Akt2 Akt1 Gsr Ccne1 Ccne2 Steap3 Tsc2 Tsc1 Tfdp2 Tfdp1 Rbl1 Rpa1 Rpa2 Rpa3 Chm E2f4 E2f5 Cdkn1b Ywhae Rptor RragB Ppm1a Mtor Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Lbr Rragc Rragd Stk11 Mlst8 Brpf3 Rnf111 Src Blm Wrn Dna2 Mre11 Ube2i Eloc Kat5 Elob Atad2 Nbn Lhb Hus1 Cga Atrip Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Rfc5 Rfc3 Rfc4 Pcna Kmt5a Rfc2 Atm Atr Exo1 Sirt1 Rmi2 Rmi1 Brip1 Sp1 Sumo1 Rhno1 Rad50 Ehmt1 Ing5 Brd1 Topbp1 Rbbp8 Brca1 Rad1 Smyd2 Brpf1 Kat6a Meaf6 Med1 Sfn Plk3 Ccnc Prdm9 Pparg Rnf34 Phf20 Gls Nr2c2 Prmt5 Gpi Cdc25c Smurf1 Mdm4 Ywhaq Ywhah Ywhaz Zfp385a Pdpk1 Ctnnb1 Men1 Sirt3 Gls2 Arnt2 Tcf7 Arnt Tcf7l1 Tcf7l2 Zfp473 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Smurf2 Polr2i Nelfe Polr2j Ctdp1 Lef1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Banp Txn Cycsl2 Cycs Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta2 Nr1h3 Mbd3 Nr1h2 Cbx3 Psmb5 Gatad2a Psmb4 Rxrb Gatad2b Psmb7 Rxra Psmb6 Ccnb1 Psmb1 Psmb3 Pgr Psmb2 Rxrg Uba52 Tbl1x Ube2d1 Psma7 Aurka Cited1 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Cdk9 Hdac3 Ubb Tbl1xr1 Rara Ubc Foxo3 Psmb6l1 Npm1 Psmd7 Ppard Psmd6 Psmd8 Myc Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Cdk2 Cdk1 Rarg Mapk1 Mt-co1 Nr5a2 Notch4 Ar Ppp2cb Ppp2ca Foxo4 Zfp839 Ddit4 Higd1c Cited4 Cited2 Zfp819 Plk2 Igfbp3 Tmem219 Atxn3 Btg2 Zik1 Cdk5r1 Usp2 Zfp867 Zfp866 Zfp612 Zim1 Zfp617 Usp7 Zfp605 Zfp46 Zfp804b Sesn2 Zfp418l1 Ppp2r1b Sesn1 Ppp2r1a Smad2 Cnot11 Cdk5 Smad3 Sesn3 Smad4 Kdm5b Tfap2e Smad7 Cnot10 Npas4 Tp53rkb Tp53rka Zfp52 Znf354c Znf354b Znf354a Tnks1bp1 Zfp90 Zfp78 Zfp74 Maged1 LOC102546572 Zfp81 Skil Cox7a1 Cox7a2 Atp1b4 Zfp873l3 Zfp398 Cox7a2l Zfp386 Cnot6l Zfp764l1 Rffl Zfp133 Znf382 Cradd Pidd1 Znf394 Tpx2 Tp63 Esrra Tp53 Esrrb Zfp273l-ps1 Esrrg Zfp180 Zfp189 Parp1 Zfp184 Ccng1 Zfp169 H2ab2 Arid1a LOC102547287 Arid1b Zfp94l1 LOC108348267 Lmo2 Zfp455l1 Lmo3 Ccnh Zfp790 Zfp317 H2ac4 Serpinb13 Zfp799 Zfpm1 Zfp300 Nr1i2 Actl6a Zfp786 Actl6b Zfp788 Smarce1 Rsl1 Gata3 Zfp770 Gata1 Znf773 Gata2 Zfp775 Setd1b Yeats4 Setd1a Ring1 Wwtr1 Abl1 Zfp764 ENSRNOG00000066901 Zfp763 Tp73 Jmy Ccnd2 Zfp111 Phc2 Zfp113 Nr3c2 Cbx6 Zfp597 Nr3c1 Ccnd3 Znf750 Phc1 Tgif1 Cbx4 Tgif2 Cbfb Zfp599 Ccnd1 Nr1d2 Cbx2 Nr1d1 Vdr Esr1 Zfp583 Phc3 Zfp101 Kmt2d Dyrk2 Crebbp Ndufa4 L3mbtl2 Cdk7 Daxx Cdk6 Dek Kmt2a Trim33 Kmt2b Znf740 Kmt2c Zfp566 H2ac18 Ing2 Zfp324 Ppara Tcf3 Bax Sin3a LOC120095871 Nr1i3 Sin3b Zfp954 Csnk2a2 Zfp951 Ctsk Trim28 Zfp790l2 Ctsl Zfp710 Csnk2a1 Pcgf2 Zfp952 Bmi1 Thrb Znf18 Mnat1 Thra Zfp719 Pbrm1 Prdx2 Brd7 Prmt6 Prdx5 Hist1h2bq Zfp704 Prmt1 Zfp945 Smarcb1 Zfp703 Hdac1 Nr5a1 Zfp706 Wdr5 Zfp948 Ash2l ENSRNOG00000070049 Yaf2 Prdx1 L3mbtl1 Csnk2b Pax5 Tp53bp2 H2aj Taf9 Taf9b Nrbf2 Tfap2c Elf1 Nrbf2l1 Tfap2a Taf15 Elf2 Tead4 Tal1 Tfap2b Taf11 Zfp758 Smarca2 Taf10 Zscan25 Smarca4 Taf13 Zscan22 Foxp3 Taf12 H3-3b Tbp Zfp746 Yap1 Taf4b Krba1 Hist3h2ba Taf7l-ps1 Ep300 Pcgf6 Noc2l Rnf2 Tead3 ENSRNOG00000068602 Ski Itch Taf8 Tead2 Smarcd1 Taf7 Tcf12 Tigar Taf6 Zfp964 Smarcd3 Taf5 Pcgf5 Hipk1 Cox6a1 Smarcd2 Taf4 Cox6a2 Ptpn11 Taf2 Zfp286a H2bc18 Taf1 Rabggta Runx1 Kat2b Rabggtb Ppp1r13l H2az2 Ppp1r13b Rbbp5 Zfp119bl H2bc4 Max Hist1h4m H2bc1 Cox6c2 Pml Cnot3 Smarcc1 Cnot2 Hist1h2ai Cnot1 Nek4 Pip4k2b Cnot7 Pip4k2c Cnot6 Pip4k2a Cnot4 Rorc Cnot9 Rorb Foxo6 Cnot8 Sgk1 Cox6b1 Nr4a1 Cox6b2 Rictor Foxg1 Prr5 G6pdx Casp2 Mga Zfp37-ps1 Mapkap1 Tbx5 E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 Nr6a1 Zfp496 Zfp808l3 Prkaa1 Pip4p1 Prkaa2 Zfp483 Cox8a Cox8c Zfp248 Nuak1 Hnf4a Cox7b Foxo1 Hnf4g Cox7c Zkscan8 Prkag3 Zkscan7 Prkag1 Zkscan1 Prkag2 Zkscan4 Zkscan5 Zkscan3 Bnip3l Nr4a3 Nr4a2 Mapkapk5 Ezh2 Zfp955a Zfp955b Bmal1 Nrif1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%10225245 Activated NTRK2 signals through FRS2 and FRS3 Grb2 Sos1 Bdnf Frs2 Ntrk2 Ntf4 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222545 Release of apoptotic factors from the mitochondria Septin4 Bak1 Gsdme Gsdmd Cycsl2 Diablol1 Cycs Bax REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-RNO-3134975.1 Regulation of innate immune responses to cytosolic DNA Sting1 Rps27a Nlrp4 Dtx4 Uba52 Tbk1 Irf3 Trim32 Ubb Ddx41 Ubc Trim21 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Cdk7 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Rngtt Polr2c Rnmt Polr2a Polr2b Mnat1 Polr2g Polr2h Polr2e Polr2f Polr2i P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10221973 p53-Dependent G1 S DNA damage checkpoint Psmb6 Zfp385a Psmb1 Psmb3 Psmb2 Phf20 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Ccna1 Psmd1 Psma3 Adrm1 Ccna2 Cdk2 Atm Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Mdm4 Psmb5 Psmb4 Psmb7 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224311 Synthesis of PIPs at the ER membrane Sacm1l Pi4ka Pi4k2b Sbf1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224945 Synthesis of PIPs in the nucleus Pip4k2b Pip4k2c Pip4p1 Pip4k2a AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane Slc36a1 Slc3a2 Slc16a10 Slc1a5 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc38a1 Slc6a12 Slc25a29 Slc6a6 Slc7a11 Slc7a10 Slc6a19 Slc7a6 Slc43a1 Slc7a7 Slc43a2 Slc7a5 Slc6a15 Slc7a3 Slc7a8 Slc3a1 Slc7a1 Slc6a14 Slc7a9 Slc36a4 Slc6a20 Slc36a2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%10222893 Signalling to ERKs Frs2 Ntrk1 Ngf Map2k2 Map2k1 Shc3 Shc1 Shc2 Mapkapk3 Mapk14 Braf Mapkapk2 Mapk3 Crkl Rapgef1 Nras Mapk1 Ralgds Grb2 Kras Rap1a Sos1 Hras Mapk11 Ywhab Crk Kidins220 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10221939 Lagging Strand Synthesis Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Rpa3 Lig1 Dna2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222593 Activation of BID and translocation to mitochondria Casp8 Nmt1 Gzmb Bid CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%10223317 Caspase-mediated cleavage of cytoskeletal proteins Plec Casp8 Casp3 Casp7 Mapt Gsn Casp6 Gas2 Vim Sh3glb2 Sptan1 Add1 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223271 Extra-nuclear estrogen signaling Ereg Esr1 Pdpk1 Btc Gnai2 Gnai1 Gnai3 Egf Calm3 S1pr3 Prmt1 Creb1 Pik3ca Shc1 Gnat3 Cav1 Akt3 Ptk2 Hbegf Akt2 Akt1 Pik3r1 Src Hsp90aa1 Nras Pik3r2 Pik3r3 Kras Uhmk1 Hras Tgfa Areg Sphk1 Zdhhc7 Xpo1 Strn Prkcz Cav2 Esr2 Igf1r Foxo3 Mmp7 Mmp2 Mmp3 Cdkn1b Zdhhc21 Egfr Mmp9 Mapk1 Nos3 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription Runx3 Smad3 Smad4 Tp53 Tgfb1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222601 Activation of BIM and translocation to mitochondria Dynll1 Bcl2l11 Mapk8 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-RNO-2029485.1 Role of phospholipids in phagocytosis Plcg1 Prkcd Pld4 Pld2 Plpp4 Plpp5 Pld3 Pik3ca Pik3r1 Pik3cb Pik3r2 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Cd3g ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 Pla2g6 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Prkce Pld1 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10223077 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Ccne1 Ccne2 Rb1 Cdk2 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins Vhl Nup133 Nup210 Nup155 Pias4 Nup153 Ube2i Trim27 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Pias1 Nup62 Pias2 Nup43 Nup88 Aaas Ranbp2 Sumo1 Nup214 Pml CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 96%10223019 Conjugation of phenylacetate with glutamine Acsm2 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 96%10222791 MyD88-independent TLR4 cascade Ppp2cb Ppp2ca Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Rps6ka1 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Birc2 Optn Rps27a Ptpn11 Skp1 Uba52 Ube2d1 Btrc Ubb Ubc Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma Jchain Hpx Alb Hp Cd163 Apoa1 LOC120093819 Ambp Lrp1 Apol7al1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 Apol2 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Apol7bl1 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 Hba1 ENSRNOG00000071049 Hbb AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 Apol9a ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10222169 RNA Polymerase I Transcription Cdk7 Rbbp4 Rbbp7 H2ac18 Mnat1 Hist1h2bq Hdac1 H2aj Tbp Polr1b H3-3b Mapk3 Polr1a Polr1f Hist3h2ba Polr1g Polr1e Polr1h ENSRNOG00000068602 Chd3 Chd4 Taf1d Rrn3 Mbd2 Taf1a Taf1c Taf1b Mta1 H2bc18 Mta2 Polr2h Mta3 Mbd3 H2az2 Polr2e Cbx3 Polr2f H2bc4 Ercc6 Hist1h4m Ubtf H2bc1 Gatad2a Gatad2b Hist1h2ai Gtf2h2 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Cavin1 Ttf1 Polr1c Hdac2 H2ab2 Ccnh H2ac4 ENSRNOG00000066901 ACTIVATION OF SMO%REACTOME%R-RNO-5635838.1 Activation of SMO Grk2 Smo Csnk1a1 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%10225215 LXR-mediated signaling Abca1 Tbl1x Ncor2 Hdac3 Nr1h3 Nr1h2 Tbl1xr1 Gps2 Ep300 Rxrb Rxra OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%10222861 Oxidative Stress Induced Senescence Phc1 Suz12 Cbx4 Eed Cbx2 Phc3 Cdk6 Kdm6b Rbbp4 Rbbp7 H2ac18 Bmi1 Hist1h2bq Map3k5 Tnik H2aj Mink1 Map4k4 H3-3b Mapk3 Hist3h2ba Rnf2 ENSRNOG00000068602 Rps27a Cdkn2b Cdkn2d H2bc18 Mapk9 H2az2 H2bc4 Hist1h4m Mapk8 H2bc1 Hist1h2ai Uba52 Fos Map2k7 Map2k6 Ubb Ubc Tp53 Txn Mapkapk3 Mapk14 H2ab2 Jun Mapkapk2 H2ac4 Map2k3 Mapk1 Mdm4 Ring1 Mapk10 Mapk11 ENSRNOG00000066901 Cdk4 Mapkapk5 Ezh2 Phc2 Cbx6 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%10225493 Formation of the dystrophin-glycoprotein complex (DGC) Megf11 Sntg2 Agrn Dtna Dtnb Sgcz Snta1 Sntb2 Sntb1 Drp2 Dag1 Sgce Sgcd Utrn Sgcb Sgca Lama4 Sspn Dmd Sgcg MITOTIC PROMETAPHASE%REACTOME%R-RNO-68877.1 Mitotic Prometaphase Ywhag Spdl1 Nup133 Actr1a Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Dctn1 Dctn2 Prkaca Ppp2r5d Akap9 Ofd1 Prkar2b Ppp2r1b Ppp2r1a Ncapd2 Ncapg Smc4 Ncaph Smc2 Eml4 Wapl Numa1 Pds5b Pds5a Cdca5 Ppp2r5b Ppp2r5a Csnk1d Ccp110 Ppp1cc Ppp2r5e Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Firrm Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Nme7 Cep152 Tuba4a Tubgcp2 Haus4 Haus5 Haus6 Pcnt Hdac8 Sfi1 Haus1 Tubgcp6 Tubgcp5 Tubgcp4 Tubgcp3 Cep250 Smc3 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Stag2 Ninl Stag1 Csnk2a2 Csnk2a1 Smc1a Csnk2b Hsp90aa1 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Ccnb1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Incenp Bub1b Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Aurkb B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Nek2l1 Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Ywhae Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Cdk1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) Ebp Dhcr24 Dhcr7 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks Kpna2 Mre11 Kat5 Rad50 Nbn Atm ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-RNO-1237044.1 Erythrocytes take up carbon dioxide and release oxygen Cyb5r1 Slc4a1 Aqp1 Ca1 Ca2 Cyb5r4 Ca4 Cyb5r2 Hba1 Cyb5rl Hbb Rhag CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME DATABASE ID RELEASE 96%10223187 Cell death signalling via NRAGE, NRIF and NADE Itgb3bp Ngf Arhgef7 Tiam1 Mcf2l Tiam2 Rac1 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Arhgef10 Arhgef12 Ngef Arhgef19 Rps27a Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Psen2 Sos2 Kalrn Ncstn Mapk8 Aph1a Traf6 Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Uba52 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Plekhg2 Ubb Net1 Arhgef10l Ubc Ywhae Rasgrf2 Ngfr Mcf2 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-RNO-8964539.1 Glutamate and glutamine metabolism Glul Got2 Rimkla Gls Rimklb Oat Pycr3 Pycr2 Pycr1 Glud1 Kyat1 Gls2 Aldh18a1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%10224655 Release of Hh-Np from the secreting cell Dhh Ihh Gpc5 Shh Notum Disp2 Scube2 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-RNO-5419276.1 Mitochondrial translation termination Mtrf1l Mt-cyb Gfm2 Mrrf Mrps9 Mrps2 Mt-atp6 Mrps7 Mrps5 Mt-nd4l Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mt-atp8 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mt-co3 Mt-co2 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223891 Other interleukin signaling Ptprz1 Il16 Txlna Csf1r Stx3 Stx1a Snap25 Csf1 Sdc1 Casp3 Vamp2 Cd4 Stxbp2 Stx4 Il34 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-RNO-1222556.1 ROS and RNS production in phagocytes Lpo Mpo Ncf1 Ncf2 Ncf4 Cyba Slc11a1 Nos2 Cybb Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Nos1 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Rac2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Nos3 Atp6v1d Hvcn1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-RNO-9909649.1 Regulation of PD-L1(CD274) transcription Suz12 Hist1h2ai Eed Rbbp4 Kmt2a Rbbp7 Kmt2c H2ac18 Hist1h2bq Wdr5 Ash2l H2aj H2ab2 H3-3b Hist3h2ba H2ac4 ENSRNOG00000068602 H2bc18 ENSRNOG00000066901 H2az2 Rbbp5 H2bc4 Ezh2 Hist1h4m H2bc1 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-RNO-9674555.1 Signaling by CSF3 (G-CSF) Jak2 Shc1 Uba52 Eloc Gab2 Ube2d1 Elob Syk Lyn Socs3 Rps27a Hck Grb2 Kras Csf3 Tyk2 Cul5 Ptpn11 Ube2d3 Ube2d2 Ubb Socs1 Ubc SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 96%10224405 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp1a1 Ephx2 Cyp1a2 Cyp1b1 Cyp2j16 Cyp2c66 Cyp2j3 Cyp2c11 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%10222549 SMAC, XIAP-regulated apoptotic response Septin4 Casp3 Casp7 Diablol1 Xiap IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223931 Ionotropic activity of kainate receptors Grik5 Grik2 Grik1 Grik4 Calm3 Grik3 Ncald Dlg1 Dlg3 Dlg4 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME DATABASE ID RELEASE 96%10225227 Biosynthesis of DPAn-3-derived maresins Alox12 Alox5 HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones Ncoa2 Phf20 Hcfc1 Kat7 Kansl3 Kansl1 Rbbp7 Kansl2 Ing4 Ing5 Brd1 Pax3 Mcrs1 Brpf3 Hist1h2bq Ogt Wdr5 Hat1 Jade1 Jade2 Jade3 Brpf1 Kat6b Kat6a Hist3h2ba Meaf6 Msl2 Msl3 Msl1 H2bc18 Kat8 Atf2 ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 96%10224609 Repression of WNT target genes Ctbp2 Lef1 Tle4 Ctbp1 Tcf7l1 Tle3 Tle2 Tcf7l2 Tle1 Tcf7 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 96%10222947 Cyclin A:Cdk2-associated events at S phase entry Ccnd1 Cdk7 Mnat1 Psma4 Ccna1 Psma3 Akt3 Ccna2 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Skp2 Skp1 Psmb5 Psmb4 Ptk6 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Cks1b Cables1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Wee1 Fzr1 Ubb Ubc Psmb6l1 Cdkn1b Psmd7 Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Ccnh Cdk2 Cdc25b Cdk4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-RNO-72702.1 Ribosomal scanning and start codon recognition Eif5 Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Rps6 Eif4e TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 96%10221951 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Ccne1 Cdkn1b Ccne2 Ccna1 Ccna2 Cdk2 E2f7 E2f8 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%10223551 Transmission across Electrical Synapses Gja10 Gjc1 Gjd2 Panx2 Panx1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%10221971 p53-Dependent G1 DNA Damage Response Psmb6 Zfp385a Psmb1 Psmb3 Psmb2 Phf20 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Ccna1 Psmd1 Psma3 Adrm1 Ccna2 Cdk2 Atm Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Mdm4 Psmb5 Psmb4 Psmb7 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%10222247 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Mtr Ywhag Frs2 Frs3 Acbd5 Sptbn1 Ptk2 Aldh3a2 Mapk3 Sptan1 Emd Grb2 Rbmx Sos1 Tra2b Usp9x Iqgap2 Ppp2r5b Ppp2r5a S100a9 Ppp1cc Abcd3 Ppp1cb Ppp2r5e Map3k11 Mapk14 Prkcb Rasgrf2 Mapk11 Ywhab Rasal2 Ncoa2 Csk Itgb1 Atp6ap1 Kif5a Kif5b Ccne1 Dock5 Dock6 Steap3 Dock3 Dock4 Dock7 Tfrc Dock8 Pik3c3 Klc1 Pik3r4 Klc4 Klc3 Klc2 Dbt Dock10 Dock11 Rab7a Ywhae Lamtor1 Lbr Kidins220 Als2 Gopc Rhoq Rab9a Rab9b Vamp3 Sh3rf1 Rhobtb3 Ckb Snap23 Pde5a Pak1 Pak2 Tpm4 Rhoa Ngef Mylk Dlg4 Ncf1 Zap70 Ncf2 Ncf4 Lck AABR07021573.2 Rhog Lrrc41 Rhob Pard6b Pard6a Rac2 Fermt2 Flna Cyba Cybb Dst Actn1 Pik3ca Arhgap32 Cav1 Farp2 Pik3r1 Pik3r2 Pik3r3 Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Sfn Rps27 Rcc2 Kif18a Nudc Vhl Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Rbbp6 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Rhot2 Cenpe Mfn1 Clasp1 Mfn2 Clasp2 Rangap1 Trak1 Myo19 Nup37 Clip1 Trak2 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Ywhaq Ywhah Birc5 Aaas Ercc6l Ranbp2 Ckap5 Ywhaz Spdl1 Nup133 Bub1 Itgb3bp Hmox2 Zwilch Pdpk1 Ctnnb1 Men1 Garre1 Shmt2 AABR07032856.1 Osbpl11 Nisch Uaca Nckap1l Wipf3 Wipf1 Itsn2 Dvl1 Mrtfa Dvl2 Stmn2 Dvl3 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Flot2 Samm50 Flot1 Fam169a Amigo2 Noxa1 Baiap2l2 Rapgef1 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 Ralgapa1 Cdc37 Chn2 Esyt1 Trip10 Wwp2 Fam135a Abi2 Abi1 Wdr11 Tuba1b Msi2 Ppp1r12b Stip1 Cpsf7 Ppp1r12a Phip Akap12 Stk38 Vrk2 Ppp1r14a Abl2 Slc1a5 Lin7b Cops4 S100a8 Arpc3 Cops2 Arpc2 Srgap1 Ubxn11 Arhgap45 Slk Cpd Cdh1 Arpc5 Cavin1 Daam1 Ctnna1 Arpc4 Pgrmc2 Picalm Tex2 Brk1 Bcr Ndufs3 Arhgap6 Jup Dsp Arhgap5 Arhgap15 Arhgap4 Arhgap17 Dsg1 Sowahc Htr7 Arhgap1 Dsg2 Stom Evl Arap1 Rhobtb2 Arap3 Rhobtb1 Arap2 Arhgap25 Arhgap9 Srf Arhgap8 Arhgap27 Mcam Slitrk5 Slitrk3 Pld1 Arhgap33 Ccdc115 Wasf3 Rtkn Wasf2 Rhpn1 Hsp90ab1 Wasf1 Rhpn2 Stk10 Plekhg1 Ralbp1 Stard8 Prc1 Maco1 Rnf20 Ddrgk1 Cct6a Faf2 Cdc42bpa Arhgdib Gmip Cdc42bpb Slc4a7 Anln Arhgap10 Arpc1b Actr2 Iqgap3 Arpc1a Diaph3 Actr3 Diaph1 Arhgap19 Btk Arhgap18 Pfn1 Depdc1b Senp1 Cit Pfn2 Vangl2 Fam13a Arhgef28 Twf1 Epsti1 C1qbp Arhgap22 Cpne8 Arhgap21 Nckap1 Arhgap20 Nipsnap2 Arhgap26 Ankle2 Arhgap24 Cyfip2 Arhgap23 Cyfip1 Arhgap29 Rhoh Arhgap28 Rhof Rhoc Ophn1 Rhoj Stbd1 Rac3 Dock2 Def6 Kif14 Vapb Rhou Pcdh7 Fam13b Scai Myo9b Nckipsd Emc3 Arhgap11a Cct7 Pak5 Myo9a Arhgap31 Ccdc88a Arhgap30 Tmem59 Prex2 Mtx1 Noxo1 Actc1 Arhgap35 Mpp7 Ankrd26 Fmnl3 Tagap Srgap2 Racgap1 Srgap3 Plekhg6 Ocrl Tmod3 Tmem87a Plekhg3 Cdc42ep1 Bcap31 Cdc42ep4 Ktn1 Plxna1 Farp1 Syde1 Dlc1 Syde2 Pld2 Stard13 Arhgap40 Elmo2 Pkn2 Rras2 Rock2 Arhgef7 Dnmbp Rock1 Nsfl1c Pkn1 Ccdc187 Arhgap44 Plxnd1 Arhgap42 Basp1 Tjp2 Ddx4 Spata13 Kdm4c Nck2 Rnd2 Rac1 Rnd3 Pak3 Rnd1 Git1 Swap70 Arhgdig Baiap2 Kctd13 Fnbp1 Bltp3b Spen Hsp90aa1 Armcx3 Ndufa5 Add3 Tor1aip1 Sema4f Lmnb1 Ptpn13 Fmnl2 Fmnl1 Sh3bp1 Prag1 Limk1 Vim Cdc20 Hspe1 Kdm1a Tnfaip1 Mad2l1 Bub1b Nck1 Aurkb Actb Prkcz Plk1 Mapk1 Stam Ar Mcf2 Arhgdia Cftr Lman1 Scfd1 Ppp2cb Grb7 Ppp2ca Prkcd Arfgap3 Prkca Calm3 Ppp2r5d Hgs Ppp2r1b Ppp2r1a Stam2 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Ccp110 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Stx5 Ykt6 Ckap4 H2ab2 H2ac4 Arl13b Abl1 ENSRNOG00000066901 Cct2 H2ac18 Hist1h2bq Actg1 Ptk2b H2aj Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 H3-3b Arhgef16 Hist3h2ba Arhgef11 Arhgef10 Arhgef12 ENSRNOG00000068602 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 H2bc18 H2az2 Sos2 Kalrn H2bc4 Hist1h4m H2bc1 Arhgef6 Hist1h2ai Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Gja1 Ddx39b Myo6 Cltc Vcp Hnrnpc Cdc42ep2 Cdc42ep3 Cdc42 Cul3 Srrm1 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%10224429 Anchoring fibril formation Bmp1 Col7a1 Tll2 Tll1 RHOBTB3 ATPASE CYCLE%REACTOME%R-RNO-9706019.1 RHOBTB3 ATPase cycle Hgs Vhl Ccne1 Rhobtb3 Lrrc41 Rab9a Rab9b Htr7 Cul3 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%10222687 Dissolution of Fibrin Clot S100a10 Serpinb2 Serpine2 Plat Anxa2 Plau Serpinb6a Serpine1 Serpinf2 Hrg Plg Plaur THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 96%10222211 The canonical retinoid cycle in rods (twilight vision) Rho Ttr Rdh11 Rdh10 Rdh12 Cyp4v2 Stra6 Rpe65 Rbp4 Rbp3 Myo7a Rlbp1 Rbp1 Lrat EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 96%10224877 Events associated with phagocytolytic activity of PMN cells Lpo Mpo RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-RNO-110328.1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Neil1 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing Il18 Casp1 Il1a Ctsg Nfkb2 Gsdmd Il1b Nfkb1 Rela ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 96%10223633 Alpha-oxidation of phytanate Pecr Phyh Slc27a2 Aldh3a2 Hacl1 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225181 RHOU GTPase cycle Arhgef6 Wdr6 Txnl1 Pak4 Rhou Git2 Epha2 Dlg5 Arhgap31 Nck1 Arhgap30 Srgap2 Dst Ptk2b Arhgef7 Itsn2 Hgs Myo6 Cltc Nck2 Pak1 Pak3 Git1 Sptbn1 Pak2 Pard6a Sptan1 Pik3r1 Stam2 Grb2 Pik3r2 Depdc1b Wwp2 Stam Cdc42 Usp9x Peak1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle Rims1 Slc17a7 Tspoap1 Syt1 Stx1a Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Gls Unc13b Snap25 Cplx1 Slc1a1 Arl6ip5 Slc38a2 Slc1a7 Vamp2 Rab3a Slc1a6 Gls2 Slc1a3 Slc1a2 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-RNO-418555.1 G alpha (s) signalling events Pde11a Arrb2 Pde4a Arrb1 Prkaca Prkacb Adrb2 Prkar1a Pde3a Prkar1b Pde7a Grk5 Itgb1 Grk6 Pde2a Pde8a Grk2 Pde8b Pde4c Pde4d Pde3b Shc1 Grk3 Prkar2a Prkar2b Pde10a Pde1b Pde1a RHO GTPASE EFFECTORS%REACTOME%R-RNO-195258.1 RHO GTPase Effectors Ywhag Spdl1 Nup133 Bub1 Itgb3bp Zwilch Pdpk1 Ctnnb1 Men1 Nckap1l Wipf3 Wipf1 Dvl1 Mrtfa Dvl2 Dvl3 Nox3 Nox1 Ptk2 Mapk3 Noxa1 Grb2 Abi2 Abi1 Iqgap2 Ppp1r12b Ppp2r5b Ppp2r5a Ppp1r12a Ppp1r14a Lin7b S100a9 Ppp1cc Ppp1cb S100a8 Arpc3 Arpc2 Ppp2r5e Cdh1 Arpc5 Daam1 Ctnna1 Arpc4 Brk1 Evl Srf Rtkn Wasf3 Rhpn1 Wasf2 Rhpn2 Wasf1 Mapk14 Prkcb Prc1 Arpc1b Actr2 Iqgap3 Arpc1a Diaph3 Actr3 Diaph1 Btk Pfn1 Pfn2 Cit Mapk11 Nckap1 Ywhab Cyfip2 Cyfip1 Rhoc Kif14 Ncoa2 Scai Nckipsd Noxo1 Fmnl3 Srgap2 Ktn1 Pkn2 Rock2 Rock1 Pkn1 Kdm4c Rac1 Kif5a Pak3 Kif5b Baiap2 Fmnl2 Fmnl1 Limk1 Cdc20 Kdm1a Pik3c3 Klc1 Pik3r4 Mad2l1 Klc4 Klc3 Bub1b Klc2 Nck1 Aurkb Actb Prkcz Ywhae Plk1 Mapk1 Ar Cftr Ppp2cb Gopc Ppp2ca Rhoq Prkcd Prkca Calm3 Ppp2r5d Pak1 Ppp2r1b Ppp2r1a Pak2 Rhoa Mylk Dlg4 Ncf1 Ncf2 Ncf4 Rhog H2ab2 Rhob Rac2 H2ac4 Flna Abl1 ENSRNOG00000066901 H2ac18 Cyba Cybb Hist1h2bq Actg1 H2aj H3-3b Hist3h2ba ENSRNOG00000068602 Pafah1b1 Zw10 Knl1 H2bc18 Ska2 Ska1 Zwint H2az2 Sfn Rps27 H2bc4 Hist1h4m Rcc2 H2bc1 Kif18a Nudc Dync1h1 Hist1h2ai Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Ywhaq Ywhah Cdc42 Birc5 Ercc6l Ranbp2 Ckap5 Ywhaz CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 96%10224557 Cellular response to heat stress Nup133 Nup210 Nup155 Nup153 Gsk3b Crebbp Hspa5 Hsf1 Hspa1b Hspa1a Mapk3 Ep300 Hsp90aa1 Eef1a1 Camk2g Camk2d Camk2b Camk2a Hspa8 Rpa1 Nup93 Rpa2 Nup50 Hsph1 Dnajc2 Rpa3 Cryab Hspa1l Nup35 Hikeshi Hspa14 Nup54 Hspa13 Nup98 Rps19bp1 Hsbp1 St13 Ywhae Nup58 Hspa12b Rptor Fkbp4 Hspa12a Hspa2 Nup37 Hsp90ab1 Bag5 Pom121 Bag3 Ptges3 Bag2 Nup205 Bag1 Mapkapk2 Mtor Nup107 Hspb8 Sec13 Dnajb6 Hspa9 Nup188 Hspa4 Tpr Nup160 Vcp Rae1 Mapk1 Ndc1 Akt1s1 Sirt1 Nup85 Nup42 Nup62 Nup43 Nup88 Dnajb1 Aaas Mlst8 Ranbp2 Nup214 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 96%10224913 Signaling by MET Arf6 Stat3 Met Ranbp9 Itgb1 Itga3 Usp8 Hgs Megf11 Pik3ca Shc1 Rac1 Ptk2 Crkl Pik3r1 Src Rapgef1 Nras Rps27a Stam2 Grb2 Lama4 Rap1a Kras Rap1b Sos1 Sh3gl3 Hras Sh3kbp1 Dock7 Ptpn11 Sh3gl1 Gab1 Uba52 Rab4a Eps15 Ptpn2 Ubb Ubc Hgf Itga2 Ptpn1 Lrig1 Tns4 Tns3 Cbl Hgfac Hpn Rab4b Gga3 Spint2 Spint1 Ranbp10 Sh3gl2 Stam Crk TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 96%10224897 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cnot3 Cnot2 Npm1 Cnot1 Cnot7 Cnot6 Cnot4 Cnot9 Cnot11 Cdc25c Cnot8 Cnot10 Cnot6l Plk2 Tnks1bp1 Btg2 Cpap Plk3 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222079 Propionyl-CoA catabolism Pcca Pccb Mmut Mmaa TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%10222279 Transport of small molecules Slco2b1 Slco2a1 Phb1 Slco4c1 SLC16A2 Slco1c1 Os9 Rnf5 Hmox1 Sel1l Magt1 Cygb Mb Ngb Slc15a1 Ctns Slc15a3 Slc15a4 Pex3 Abcd1 Scarb1 Abcd2 Slc26a2 Abcd3 Slc26a1 Slc35b3 Slc35b2 Slc26a11 Myo5b Aqp4 Aqp3 Aqp2 Pex19 Slc22a3 Arl2 Ap2s1 Ap2a2 Ap2a1 Ap2b1 Bmp1 Zdhhc8 Furin Abcc3 Apoc1 Apoc4 Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Slc13a4 Atp6v0a1 Slc13a1 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Ldlr Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Rab11a Atp6v1d Hfe Tf Steap3 Steap4 Mcoln1 Tfrc Tfr2 Fth1-ps5 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc67a1 Fth1 Slc44a2 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc33a1 Slc4a9 Slc10a6 Slc22a8 Slc22a7 Slc12a1 Slc45a3 Slc12a4 Slc35d1 Slc12a5 Slc22a6 Slc12a2 Lcn12 Slc12a3 Slc22a5 Slc12a6 Slc22a4 Slc12a7 Slc5a1 Slc5a3 Slc34a3 Ftl1 Slc5a2 Slc5a4 Slc5a7 Slc35c1 Slc11a2 Apod Abcc4 Slc27a1 Arl2bp Slc25a26 Slc25a29 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Emb Slc39a8 Slc39a7 Slc39a6 Slc16a7 Slc2a13 Slc6a6 Slc2a12 Slc16a3 Slc2a10 Slc16a8 Slc31a1 Fgf21 Slc16a1 Slc28a3 Slc28a2 Slc28a1 Slc20a2 Slc20a1 Slc43a1 Slc43a2 Slc17a1 Slc7a3 Slc7a1 Mfsd4b4 Slc29a3 Slc29a2 Slc29a1 Slc29a4 Slc30a10 Slc25a1 Slc40a1 Slc14a2 Slc14a1 Slc26a6 Pcsk5 Slc26a4 Slc26a3 Slc26a9 Slc8b1 Slc26a7 Slc41a2 Lcn9 Slc41a1 Slc1a1 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc1a7 Slc1a6 Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc6a12 Slc9a9 Add1 Slc9a6 Slc9a7 Slc27a4 Slc27a6 Slc35b4 Slc5a10 Slc5a12 Slc5a11 Slc2a2 Slc2a4 Atp2a1 Slc2a8 Slc2a7 Atp2a3 Slc2a9 Atp2a2 Slc35a3 Slc35a2 Slc39a14 Slc50a1 Kcnj11 Trpc7 Slc24a5 Abcc9 Trpc3 Slc47a1 Slc24a4 Slc24a3 Slc24a2 Atp2b1 Slc24a1 Camk2g Atp2b4 Ahcyl2 Camk2d Atp2b3 Slc22a15 Camk2b Vegp2 Vegp1 Slc22a12 Slc22a16 Slc3a1 Slc13a5 Cyb5r4 Sri Slc36a4 Cyb5r2 Camk2a Slc13a3 Cyb5rl Slc36a2 Slc36a1 Wwp1 Slc3a2 Slc13a2 Slc4a10 Atp1b1 Slc16a10 Heph Atp1b3 Slc25a5 Atp1b2 Slc25a4 Ryr2 Ryr1 Fkbp1b Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Pln Asph Trpc1 Angptl4 Raf1 Mylip Ano6 Ano5 Slc7a11 Slc7a10 Slc7a6 Afg3l2 Slc7a7 Clcn2 Clcn1 Slc7a5 Cand1 Slc7a8 Parl Slc7a9 Nipal4 Nipal2 Nipal3 Nipal1 Lipa Slc8a1 Lipc Slc8a2 Pheta2 Ano10 Ttyh3 Slc8a3 Ttyh1 Ttyh2 Dmtn Slc17a3 Nipa1 Nipa2 Fbxl5 Pcsk6 Trpc4ap Esyt3 Esyt2 Pmpcb Pmpca Aqp12a Rhcg Rhbg Atp9b Atp9a Best4 Ireb2 Pip Best1 Best3 Mcu Best2 Nceh1 Atp7b Clca1 Clca2 Clca4 Cyb5r1 Trpc5 Trpc4 Apobr Stoml3 Unc80 Npc2 Npc1 Atp2c1 Atp2c2 Scnn1a Lmf1 Scnn1b Lmf2 Unc79 Apoa5 Scnn1g Lrrk1 Trpa1 Slc5a5 Maip1 Tpcn1 Bsnd GLTP Aqp9 Eif2s3 Aqp8 Aqp7 Aqp5 Pcsk9 Eif2s2 Atp4a Atp4b Eif2s1 Mip Ankh Cp Mrs2 Plekha8 Trpm2 Trpm1 Azgp1 Soat2 Soat1 Ano9 Ano8 Trpm8 Trpm7 Ano7 Micu2 Micu3 Trpm4 Ano4 Trpm3 Micu1 Ano3 Trpm6 Ano2 Ano1 Vldlr Sgk3 Sgk2 Slc66a1 Mcub Asic5 Angptl8 Asic4 Atp10a Atp10b Slc38a1 Atp10d Slc1a3 Asic1 Slc1a2 Asic3 Asic2 Angptl3 Cybrd1 Atp11b Atp11a Atp11c Atp13a1 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Ftmt Atp13a2 Atp13a4 Atp13a5 Hdlbp Atp12a Trpv5 Trpv4 Trpv6 Trpv1 Trpv3 Trpv2 Nalcn Tsc22d3 Clcnkb Clcnka Aqp11 Spg7 Add2 Mcoln3 Slc22a17 Mcoln2 Clcn6 Clcn7 Clcn4 Clcn5 Hmox2 Lrrc8e Cptp Abcg2 Lrrc8a Abcc1 Lrrc8b Abcc2 Lrrc8c Cln3 Lrrc8d Aqp10 Abcb1 Alb Mttp Apoc2 Apoa1 Apoc3 Apoa2 Abcf1 Abcb6 Sar1b Abcb7 Apoe Abcb4 Apoa4 Abcb5 P4hb Abcb8 Apob Abcb9 Esyt1 Abcg4 Abcg8 Abcg5 Abcc5 Abcc6 Abca12 Abcc10 Lpl Gpihbp1 Abca2 Abca5 Abca6 Abca9 Abca7 Abca8 Slc1a5 Yme1l1 Stom Stoml2 Phb2 Avpr2 Slc4a7 Slc35d2 Bsg Psma4 Psma3 A2m Psma6 Psma5 Psma2 Psma1 Rps27a Add3 Psmd12 Psmd11 Psmd14 Psmd13 Nr1h3 Nr1h2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ldlrap1 Psmb1 Psmb3 Psmb2 Uba52 Avp Psma7 Psmc5 Psmc2 Slc5a6 Psmc1 Slc5a8 Psmc4 Abca1 Psmc3 Cubn Ubb Slc46a1 Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Slc2a1 Psmd1 Slc2a3 Adrm1 Cul1 Amn Gng10-ps1 Cftr Prkaca Prkacb Prkar1a Nedd8 Lipg Prkar1b Pltp Calm3 Lcat Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Prkar2a Prkar2b Atp7a Gnb2 Arf1 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Slc22a2 Slc6a19 Slc6a5 Slc22a1 Slc32a1 Slc6a7 Slc6a15 Slc6a9 Slc6a14 Slc6a11 Gnas Slc6a13 Slc6a20 Slc25a18 Slc25a22 Slc6a2 Slc17a7 Slc6a1 Slc17a8 Slc6a4 Slc6a3 Slc17a6 Slc34a1 Ca1 Ca2 Ca4 Hba1 Hbb Rhag Slc34a2 Slc4a1 Aqp1 Slc11a1 Abca3 Lcn2 Slc30a5 Slc30a8 Aco1 Runx1 Slc25a10 Nek4 Sgk1 Slc17a5 Slc35a1 Ap2m1 Clta Cltc Rnf185 Derl3 Derl2 Slc25a11 Erlin2 Erlin1 Vcp Slc30a1 Tusc3 Slco3a1 Erlec1 Slco1a4 Slco4a1 Slco1b2 TGFBR3 PTM REGULATION%REACTOME DATABASE ID RELEASE 96%10225439 TGFBR3 PTM regulation Aph1b Mmp16 Timp2 Tgfbr3 Psenen Psen1 Psen2 Ncstn Mmp14 Aph1a Timp1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%10224301 Resolution of Sister Chromatid Cohesion Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Firrm Hdac8 Smc3 Stag2 Stag1 Smc1a Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Ccnb1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Incenp Bub1b Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Aurkb B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Cdk1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 Psmb6 Psmb1 Psmb3 Psmb2 Phf20 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Atm Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Mdm4 Psmb5 Psmb4 Psmb7 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis Ereg Wnt5a Btc Ttgn1 Igf2r M6pr Vamp3 Adrb2 Vamp4 Nedd8 Grk2 Tacr1 Itsn2 Hgs Dvl2 Slc2a8 Fzd4 Hbegf Grb2 Stam2 Gps1 Apob Chrm2 Vamp2 Tgfa Areg Lrp2 Arrb2 Arrb1 Il7r Cops4 Cops2 Cd3g Picalm Eps15 Cd3d Cd4 Avpr2 Egfr Syt1 Ap2s1 Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Slc18a3 Egf Ston1 Ston2 Eps15l1 Tor1a Tor1b Scarb2 Ldlr Cops3 Cops6 Cops8 Aak1 Rps27a Syt11 Tf Itsn1 Sh3gl3 Sh3kbp1 Tfrc Agtr1 Sh3gl1 Ldlrap1 Fcho1 Vamp7 Fcho2 Vamp8 Uba52 Necap2 Necap1 Avp Agfg1 Cops7a Cops7b Ubb Ubc Ap2m1 Clta Cltb Cltc Dab2 Grk3 Snap91 Syt2 Syt9 Syt8 Ubqln2 Cbl Ubqln1 Epn2 Epn1 Reps1 Reps2 Cops5 Stam Cftr PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis Adss2 Pfas Paics Gart Adss1 Gmps Impdh2 Atic Adsl Impdh1 Ppat CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-421270.1 Cell-cell junction organization Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Xiap Src Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Pard3 Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Cdh8 Vcl Hdac2 Jak2 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Pard6b Il6 Pard6a Kmt5a H2ac4 Sec11c Amot Sec11a Il6r Prkcsh Sirt1 Pard6g Zmym2 Cadm3 Sp1 ENSRNOG00000066901 Cdh24 Cadm2 Cadm1 Rnf19b F11r Pomt1 Sdk1 Hace1 Dnttip1 Pomt2 Stat3 Furin Pcsk7 Pcsk6 Sdk2 Birc2 H2ac18 Adam19 Afdn Ctbp2 Csnk2a2 Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Cdh18 Cdh17 Cdh15 Hist1h2bq Cdh13 Cdh12 Hdac1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 H2aj Canx Tiam1 Arhgap32 Spcs3 Prkci Rac1 Spcs1 Spcs2 Psma4 Smarca4 Farp2 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Vav2 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Arhgef4 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-RNO-9958863.1 SLC-mediated transport of amino acids Slc36a1 Slc3a2 Slc16a10 Slc1a5 Slc1a1 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc1a7 Slc1a6 Slc38a1 Slc6a12 Slc1a3 Slc1a2 Slc25a29 Slc6a6 Slc7a11 Slc7a10 Slc6a19 Slc7a6 Slc43a1 Slc7a7 Slc43a2 Slc7a5 Slc6a15 Slc7a3 Slc7a8 Slc3a1 Slc7a1 Slc6a14 Slc7a9 Slc36a4 Slc6a20 Slc36a2 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223857 Hydroxycarboxylic acid-binding receptors Hcar1 Hcar2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 96%10221943 Removal of the Flap Intermediate Fen1 Pold2 Pold1 Pcna Pola2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Rpa3 Dna2 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-RNO-9975921.1 Assembly of the 9+0 primary cilium Ywhag Actr1a Dctn1 Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Rpgrip1l Septin2 Kif24 Ttbk2 Ift140 Tctn3 Fbf1 Tctn1 Kif3a Akap9 Tctn2 Iqcb1 B9d1 Cep89 Mks1 Ahi1 Ift52 Nphp4 Ttc21b Cep83 Ift57 Nphp1 Ift122 Ofd1 Sclt1 Tmem216 Wdr35 Prkar2b Dync2h1 Ppp2r1a Ift172 Wdr19 Arf4 Cep97 Csnk1d Ccp110 Gbf1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Pcm1 Dynlrb2 Ssna1 Dynlrb1 Ift70b Tubg1 Ift81 Cep63 Dynlt2b Sstr3 Ift80 Cep152 Dynlt5 Tuba4a Dynlt2 Haus4 Haus5 Kif17 Haus6 Pcnt Trip11 Sfi1 Dync2i1 Haus1 Dync2li1 Dync2i2 Cluap1 Traf3ip1 Mkks Ift20 Unc119b Arl13b Cep250 Ift22 Pkd1 Cep290 Cep78 Ift27 Rp2 Cep76 Ift25 Asap1 Cep72 Ift56 Bbs9 Bbs7 Cep164 Cep70 Bbs5 Ift43 Cpap Bbs4 Tubb5 Cct3 Ift46 Plk4 Cct2 Ift74 Odf2 Bbs10 Ift70a2 Bbs12 Alms1 Thoc2l Cetn2 Cngb1 Exoc3 Cep135 Exoc4 Cep43 Exoc5 Cep41 Exoc6 Cep131 Exoc1 Tubb4b Exoc2 Tubb4a Exoc7 Ninl Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Pde6d Ttc8 Nphp3 Lztfl1 Mchr1 Hsp90aa1 Rab11a Pafah1b1 Dync1h1 Kifap3 Dync1i2 Kif3b Tnpo1 Kif3c B9d2 Nde1 Nek2l1 Rho Clasp1 Ywhae Plk1 Smo Cdk1 Mapre1 Dynll1 Dynll2 Ckap5 Csnk1e Rab3ip RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225345 RND2 GTPase cycle Nudc Wdr6 Txnl1 Kif14 Epha2 Frs2 Dlg5 Frs3 Ubxn11 Arhgap35 Ankrd26 Dst Arhgap5 Ktn1 Dsg1 Arhgap1 Nisch Ckap4 Plxnd1 Scrib Fam83b Rnd2 Cav1 Aldh3a2 Kctd13 Fnbp1 Pik3r1 Bltp3b Golga3 Pik3r2 Rbmx Depdc1b Ptpn13 Vangl2 Tfrc Muc13 Prag1 Kidins220 Tnfaip1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases Atp9b Atp9a Calm3 Atp7b Atp2a1 Atp2c1 Atp2c2 Atp2a3 Atp7a Atp2a2 Atp2b1 Camk2g Atp2b4 Camk2d Atp2b3 Camk2b Atp4a Atp4b Sri Camk2a Atp1b1 Atp1b3 Atp1b2 Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Pln Atp10a Atp10b Atp10d Atp11b Atp11a Atp11c Atp13a1 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%10224487 Nuclear Envelope Breakdown Nup133 Ccnb1 Nup210 Nup155 Nup153 Vrk2 Prkca Nek9 Ctdnep1 Cnep1r1 Lpin3 Nup93 Lpin2 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Plk1 Nup205 Prkcb Nup107 Sec13 Nup188 Tpr Vrk1 Emd Cdk1 Nup160 Rae1 Lmna Ndc1 Lmnb1 Nup85 Nup42 Nup62 Ccnb2-ps2 Nup43 Nup88 Banf1 Aaas Ccnb2 Ranbp2 Nup214 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225195 Miro GTPase Cycle Rhot2 Mfn1 Mfn2 Trak1 Myo19 Trak2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) Pigb Dpm2 Piga Pigm Pigl Pigg Pigf Pigh Pign Pigq Pigp Pigw Pigv Pigx Pigc RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%10222173 RNA Polymerase I Promoter Escape Hist1h2ai Gtf2h2 Gtf2h1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 H2ac18 Polr1c Mnat1 Hist1h2bq H2aj H2ab2 Tbp Polr1b H3-3b Polr1a Hist3h2ba Ccnh Polr1f H2ac4 Polr1g Polr1e ENSRNOG00000068602 Polr1h Taf1d Rrn3 Taf1a Taf1c Taf1b H2bc18 Polr2h ENSRNOG00000066901 H2az2 Polr2e Cbx3 Polr2f H2bc4 Hist1h4m Ubtf H2bc1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%10224981 PTK6 Regulates Proteins Involved in RNA Processing Sfpq Khdrbs1 Khdrbs3 Khdrbs2 Ptk6 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-RNO-5389840.1 Mitochondrial translation elongation Gfm1 Mrps9 Mrps2 Mrps7 Mrps5 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%10223873 Synthesis of GDP-mannose Gmppa Pmm2 Mpi Pmm1 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%10225009 TBC RABGAPs Sytl1 Gabarap Tbc1d25 Tbc1d24 Arf6 Map1lc3b Rab4a Rabgap1 Rab33b Rab33a Tbc1d2 Tbc1d7 Gabarapl2 Rab8b Rab8a Rab7a Rab7b Tbc1d14 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Optn Rab11b Tbc1d10c Rab11a Rab35 Tsc2 Tsc1 Tbc1d10b Rab6b Tbc1d10a Rab6a Ulk1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223785 SIRT1 negatively regulates rRNA expression Suv39h1 Rrp8 Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Sirt1 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223611 Vasopressin-like receptors Avpr2 Oxtr Oxt Avpr1b Avp Avpr1a LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223439 Laminin interactions Nid2 Megf11 Lama4 Itgb1 Itga6 Itga7 MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 96%10224991 MET activates RAS signaling Hgf Grb2 Kras Shc1 Sos1 Hras Ranbp10 Met Nras Ranbp9 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-RNO-879415.1 Advanced glycosylation endproduct receptor signaling Capza1 Capza2 App S100b Ager Hmgb1-ps34 Hmgb1l2 Hmgb1l1 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225389 Regulation of CDH11 gene transcription Zeb2 Sp1 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling Jak3 Shc1 Il2ra Il2rb Lck Il2 Syk Ptk2b Stat5a Stat5b RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222309 RNA Polymerase III Transcription Initiation From Type 1 Promoter Gtf3c5 Bdp1 Tbp Polr3gl Gtf3a Crcp Polr3a Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr2h Polr3f Polr3g Polr2e Gtf3c2 Polr2f Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH Rfc5 Ufd1 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Vcp Rps27a Nploc4 Sprtn Rchy1 Rpa1 Rpa2 Ubb Rpa3 Ubc Polh INTERLEUKIN-38 SIGNALING%REACTOME%R-RNO-9007892.1 Interleukin-38 signaling Il1rl2 Il1f10 Il1rapl1 Mapk8 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190375.1 FGFR2c ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf5 Fgf8 Fgf9 Fgfr2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176814.1 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%10222387 PI3K Cascade Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 RHOBTB GTPASE CYCLE%REACTOME%R-RNO-9706574.1 RHOBTB GTPase Cycle Cpsf7 Txnl1 Phip Stk38 Rbbp6 Cct7 Cops4 Cops2 Actb Tmod3 Rhobtb2 Rhobtb1 Actn1 Rock2 Ddx39b Rock1 Myo6 Pde5a Hsp90ab1 Rnf20 Cct6a Spen Hsp90aa1 Gps1 Rbmx Hnrnpc Cdc37 Tra2b Twf1 Cct2 Cul3 Vim Msi2 Srrm1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%10223773 Arachidonate production from DAG Mgll Abhd12 Dagla Daglb Abhd6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%10224759 Phospholipase C-mediated cascade; FGFR2 Fgf16 Fgf17 Fgf18 Fgf10 Plcg1 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Fgfr2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%10224449 Establishment of Sister Chromatid Cohesion Smc3 Stag2 Esco1 Stag1 Wapl Esco2 Pds5b Pds5a Cdca5 Smc1a REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-RNO-170822.1 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup133 Nup210 Nup155 Nup153 Gck Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Gckr Aaas Ranbp2 Nup214 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-RNO-68881.1 Mitotic Metaphase Anaphase Transition Plk1 Fbxo5 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224821 LGI-ADAM interactions Adam22 Cacng8 Cacng3 Stx1a Cacng4 Cacng2 Stx1b Lgi2 Lgi3 Lgi4 Lgi1 Dlg4 Adam23 Adam11 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-RNO-983695.1 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Itpr3 Itpr2 Itpr1 Ptpn6 Pik3r1 Cd19 Grb2 Vav1 Sos1 Pik3cd Sh3kbp1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Dapp1 ENSRNOG00000070415 Cd22 ENSRNOG00000070810 Blnk ENSRNOG00000066926 Cd79a ENSRNOG00000066406 Cd79b ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Syk Iglc1 Nck1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 Trpc1 ENSRNOG00000063707 Plcg2 Stim1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Btk ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10225283 Assembly and cell surface presentation of NMDA receptors Grin2a Grin1 Grin2d Grin2c Grin2b Grin3a REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade Cpb2 Cr2 Serping1 Cr1l Clu Cd81 C4b C1qb C1qa Cfh Cfi C2 C5ar2 Elane C4 C5ar1 C9 Cd46 Cfhr1 C1s C1r Cpn1 Cpn2 Cd19 C1qc ENSRNOG00000069193 AABR07065813.1 F2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 C3ar1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C3 C5 Cd55 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-RNO-5610780.1 Degradation of GLI1 by the proteasome Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Gli1 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Sufu Numb Skp1 Psmb5 Psmb4 Psmb7 RAS PROCESSING%REACTOME%R-RNO-9648002.1 RAS processing Golga7 Arl2 Abhd17b Abhd17a Prkcq Lypla1 Nras Icmt Kras Pde6d Fnta Abhd17c Hras Bcl2l1 Calm3 Fntb Rce1 ENSRNOG00000067432 Prkg2 Zdhhc9 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224159 SHC1 events in ERBB2 signaling Prkce Egfr Erbb2 Shc1 Erbb3 Ereg Nrg2 Ptpn12 Nrg3 Hbegf Prkcd Btc Prkca Egf INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling Ifngr2 Ybx1 Ifngr1 Raf1 Jak2 Stat1 Ptpn6 Mapk3 Prkcd Socs3 Mapk1 Camk2g Camk2d Camk2b Pias1 Ptpn2 Socs1 Sumo1 Camk2a Ifng CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%10224845 CD22 mediated BCR regulation Ptpn6 Lyn ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 Cd22 ENSRNOG00000070810 ENSRNOG00000066926 Cd79a ENSRNOG00000066406 Cd79b ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-RNO-5693607.1 Processing of DNA double-strand break ends Sumo3 Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Ccna1 Ccna2 Hist3h2ba Blm Wrn H2bc4 Hist1h4m H2bc1 Dna2 Ppp4r2 Pias4 Ube2n Mre11 Ube2i Kat5 Timeless Nbn Hus1 Atrip Sirt6 Chek1 Ube2v2 Rad9a Rpa1 Rad9b Rpa2 Bard1 Top3a Rpa3 Ppp4c Clspn Rad17 Rfc5 Rfc3 Rfc4 Rfc2 Cdk2 Atm Atr Tp53bp1 Exo1 Rmi2 Rmi1 Brip1 Brcc3 ENSRNOG00000066901 Herc2 Rnf168 ABRAXAS1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-RNO-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Pold2 Pold1 Mlh1 Msh6 Pcna Msh2 Pms2 Pold4 Pold3 Exo1 Rpa1 Rpa2 Rpa3 Lig1 RAC3 GTPASE CYCLE%REACTOME%R-RNO-9013423.1 RAC3 GTPase cycle Lman1 Ophn1 Stbd1 Rac3 Noxo1 Arhgap35 Mpp7 Cyba Srgap2 Vamp3 Cybb Racgap1 Ocrl Cdc42ep1 Garre1 Itgb1 Syde1 Nckap1l Arhgap42 Snap23 Jag1 Tiam1 Arhgap32 Pak1 Cav1 Nox3 Swap70 Git1 Nox1 Pak2 Baiap2 Amigo2 Noxa1 Pik3r1 Rapgef1 Emd Baiap2l1 Pik3r2 Taok3 Vav2 Esyt1 Tfrc Abi2 Abi1 Pak4 Vrk2 Git2 Epha2 Abl2 Slc1a5 Ncf1 Abr Dock10 Ncf2 Ykt6 Ncf4 Pgrmc2 Brk1 Prex1 Bcr Trio Arhgap6 Arhgap15 Arhgap5 Arhgap17 Arhgap1 Dsg2 Arap3 Arap2 Rab7a Mcam Slitrk5 Slitrk3 Wasf2 Wasf1 Arhgdib Diaph3 Fermt2 Depdc1b Lamtor1 Lbr Cdc42 Arhgap21 Nckap1 Mcf2 Arhgap26 Cyfip1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-RNO-446652.1 Interleukin-1 family signaling Il33 Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Il1b Il1r2 Il1r1 Il1rl2 Nkiras1 Il1f10 App Ikbkb Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Gsdmd Nfkb1 Traf2 Fbxw11 Il36a Il36rn Il36g Alpk1 Rela Il18rap Il18r1 Il18bp Peli2 Il18 Peli3 Tifa Tnip2 S100b Map2k6 Hmgb1-ps34 N4bp1 Casp8 Nfkbib Tbk1 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Usp14 Tab3 Tab2 Usp18 Tab1 Ctsg Nlrc5 Chuk Stat3 Il1rapl1 Psma4 Psma3 Sqstm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Il1rl1 Myd88 Ubb Ubc Psmb6l1 Psmd7 Casp1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%10222627 PAOs oxidise polyamines to amines Smox ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 96%10224235 Acyl chain remodeling of DAG and TAG Dgat2l6 Mgll Dgat2 Dgat1 Pnpla3 Awat2 Pnpla2 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing Polr2j Sf3b1 Ncbp2 Ncbp1 Sf3b3 Sf3b4 Sf3b5 Snrpepl2 Gtf2f2 Prpf6 Gtf2f1 Zmat5 Pdcd7 Prpf8 Snrnp200 Zcrb1 Snrpf Snrnp40 Eftud2 Snrnp48 Snrpg Ybx1 Snrpb Ddx42 Rnpc3 Zrsr2 Snrpd1 Snrnp25 Polr2c Polr2a Polr2b Srsf1 Polr2g Ddx23 Polr2h Polr2e Srsf7 Polr2f Snrpd3 Polr2i Srsf2 Snrnp35 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%10224037 Spry regulation of FGF signaling Ppp2cb Ppp2ca Uba52 Braf Ppp2r1a Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Ubb Ubc REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA Slc6a1 Slc6a11 Slc6a13 Slc6a12 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%10223287 Negative regulation of the PI3K AKT network Erbb2 Ppp2cb Ins2 Erbb3 Ppp2ca Ereg Frs2 Btc Il33 Pdgfa Ppp2r5d Pdgfb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Il1rap Irak4 Fgf17 Fgf18 Fgf19 Ppp2r1b Ppp2r1a Fgf10 Mapk3 Hbegf Src Ntrk3 Ntf3 Grb2 Fyn Tgfa Fgf20 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pten Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Lck Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Hgf Egfr Rhog Irak1 Rac2 Pdgfrb Pdgfra Kl Flt3 Esr1 Nrg2 Nrg3 Met Egf Trib3 Them4 Pik3ca Insr Rac1 Gab2 Pip5k1c Akt3 Akt2 Akt1 Pik3r1 Pik3cb Cd19 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pik3r5 Pik3cg Irs2 Ier3 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Pik3ap1 Cd28 Icos Ntf4 Pip5k1a Strn Cd86 Cd80 Esr2 Bdnf Il1rl1 Trat1 Myd88 Ntrk2 Mapk1 Pik3r6 Ins1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450408.1 AUF1 (hnRNP D0) binds and destabilizes mRNA Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Hspa8 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Hspa1b Psmc3 Hspa1a Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Hnrnpd Psmd14 Psmd13 Hspb1 Pabpc1 Psmb5 Psmb4 Psmb7 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 96%10223073 Signaling by VEGF Pdpk1 Prkaca Ctnnb1 Prkacb Plcg1 Prkcd Prkca Cyba Cybb Mapk12 Rasa1 Trib3 Calm3 Flt1 Flt4 Itgb3 Vegfa Kdr Elmo2 Ptk2b Nckap1l Vegfd Vegfc Rock2 Pgf Rock1 Vegfb Them4 Pxn Pik3ca Nck2 Rac1 Pak1 Cav1 Pak3 Pak2 Akt3 Baiap2 Ptk2 Akt2 Akt1 Pik3r1 Src Rhoa Pik3cb Hsp90aa1 Nras Vav3 Pik3r2 Fyn Vav1 Kras Vav2 Mapk13 Hras Abi2 Abi1 Sphk1 Nck1 Ncf1 Ncf2 Ncf4 Rictor Ctnna1 Prkcz Brk1 Prr5 Nrp1 Jup Nrp2 Shb Ctnnd1 Sh2d2a Elmo1 Mapkap1 Axl Bcar1 Wasf3 Wasf2 Shc2 Mapkapk3 Wasf1 Mapk14 Prkcb Mapkapk2 Mtor Nos3 Hspb1 Cdc42 Mapk11 Nckap1 Itgav Mlst8 Crk Cyfip2 Cyfip1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes Plod1 Plod2 Adamts3 Bmp1 Adamts2 Col15a1 Col13a1 Col19a1 Col25a1 Col4a1 Col4a2 Adamts14 P4hb Col7a1 Tll2 Tll1 Gpr162 Col14a1 Col10a1 Ppib Col1a2 Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Col24a1 Col4a4 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 P3h1 Crtap Col18a1 Pcolce2 Colgalt2 Col2a1 Col27a1 Col6a2 Serpinh1 Col23a1 Col6a5 Col6a6 Col26a1 Col4a5 Col6a3 Col8a1 Col4a6 Col8a2 Plod3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 96%10224849 Gap-filling DNA repair synthesis and ligation in GG-NER Pole Rfc5 Pold2 Uba52 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pold3 Rps27a Pole3 Pole2 Pole4 Rpa1 Rpa2 Polk Ubb Rpa3 Ubc RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-RNO-73857.1 RNA Polymerase II Transcription Runx3 Ywhag Suz12 Cox5a Cox5b Zfp12 Eed Zfp13 Zfp950l16 Zfp282 Ttc5 Nr2c1 Ice2 Kctd1 Rbbp4 Pou4f1 Rbbp7 Znf431l2 Pou4f2 Zfp668 Prkab2 Znf689 Prkab1 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Ssu72 Znf624l Ube2d3 Zfp641 Zfp647 Znf667 Znf426 Aff4 Cox4i1 Cox4i2 Nr2f6 Nr0b2 Nr0b1 Nr2f1 Nr2e3 Gadd45a Zfp212 Zfp213 Zfp455 LOC134478826 Mapk3 Rex2l4 Zfp445 Zfp688 Zfp950l5 Usp9x Snapc3 Snapc4 Snapc1 Snapc2 Map2k6 Lamtor3 Kat2a Lamtor2 Maml3 Rbpj Hdac2 Hdac5 Hdac4 Maml1 Mapk14 Hdac11 Maml2 Hdac10 Notch3 Hdac9 Hdac8 Cpap Mapk11 Ywhab Gpx2 Tgfb1 Wwox Furin Nr1h4 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Txnrd1 Akt3 Akt2 Akt1 Gsr Ccne1 Ccne2 Steap3 Tsc2 Tsc1 Tfdp2 Tfdp1 Rbl1 Rpa1 Rpa2 Rpa3 Chm E2f4 E2f5 Cdkn1b Ywhae Rptor RragB Ppm1a Mtor Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Lbr Rragc Rragd Stk11 Mlst8 Brpf3 Rnf111 Src Blm Wrn Dna2 Mre11 Ube2i Eloc Kat5 Elob Atad2 Nbn Lhb Hus1 Cga Atrip Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Rfc5 Rfc3 Rfc4 Pcna Kmt5a Rfc2 Atm Atr Exo1 Sirt1 Rmi2 Rmi1 Brip1 Sp1 Sumo1 Rhno1 Rad50 Ehmt1 Ing5 Brd1 Topbp1 Rbbp8 Brca1 Rad1 Smyd2 Brpf1 Kat6a Meaf6 Med1 Sfn Plk3 Ccnc Prdm9 Pparg Rnf34 Phf20 Gls Snrpf Snrpg Snrpb Nr2c2 Prmt5 Gpi Cdc25c Ctr9 Paf1 Smurf1 Mdm4 Ywhaq Ywhah Snrpd3 Ywhaz Zfp385a Snrpepl2 Pdpk1 Ctnnb1 Men1 Sirt3 Gls2 Arnt2 Tcf7 Arnt Tcf7l1 Tcf7l2 Cdc73 Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Polr2c Cstf2 Polr2a Cstf3 Polr2b Cstf2t Polr2g Lsm10 Polr2h Lsm11 Nelfa Sympk Polr2e Pabpn1 Polr2f Clp1 Nelfb Smurf2 Cpsf4 Polr2i Nelfe Cpsf6 Cpsf7 Polr2j Ctdp1 Cpsf1 Lef1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Leo1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Banp Slbp Txn Cycsl2 Cycs Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta2 Nr1h3 Mbd3 Nr1h2 Cbx3 Psmb5 Gatad2a Psmb4 Rxrb Gatad2b Psmb7 Rxra Psmb6 Ccnb1 Psmb1 Psmb3 Pgr Psmb2 Rxrg Uba52 Tbl1x Ube2d1 Psma7 Aurka Cited1 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Cdk9 Hdac3 Pou2f1 Ubb Tbl1xr1 Rara Ubc Foxo3 Psmb6l1 Npm1 Psmd7 Ppard Psmd6 Psmd8 Myc Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Cdk2 Cdk1 Rarg Mapk1 Mt-co1 Nr5a2 Notch4 Ar Ppp2cb Ppp2ca Foxo4 Zfp839 Ddit4 Higd1c Cited4 Cited2 Zfp819 Plk2 Igfbp3 Phax Tmem219 Ell2 Ell3 Atxn3 Btg2 Zik1 Cdk5r1 Usp2 Zfp867 Zfp866 Zfp612 Zim1 Zfp617 Usp7 Zfp605 Zfp46 Zfp804b Rprd1a Rprd1b Supt6h Sesn2 Zfp418l1 Ppp2r1b Sesn1 Ppp2r1a Smad2 Cnot11 Cdk5 Smad3 Sesn3 Smad4 Kdm5b Tfap2e Smad7 Cnot10 Npas4 Tp53rkb Tp53rka Zfp52 Znf354c Znf354b Znf354a Tnks1bp1 Zfp90 Zfp78 Zfp74 Maged1 LOC102546572 Zfp81 Skil Cox7a1 Cox7a2 Mllt3 Mllt1 Atp1b4 Zfp873l3 Ints4 Ints5 Ints6 Zfp398 Ints7 Ints8 Ints9 Cox7a2l Ints1 Ints2 Ints3 Zfp386 Cnot6l Zfp764l1 Rffl Zfp133 Znf382 Cradd Pidd1 Znf394 Tpx2 Tp63 Nabp1 Nabp2 Esrra Tp53 Esrrb Zfp273l-ps1 Skic8 Esrrg Zfp180 Zfp189 Parp1 Zfp184 Ccng1 Zfp169 H2ab2 Arid1a LOC102547287 Arid1b Zfp94l1 LOC108348267 Lmo2 Zfp455l1 Lmo3 Ccnh Zfp790 Zfp317 H2ac4 Serpinb13 Zfp799 Zfpm1 Zfp300 Nr1i2 Actl6a Zfp786 Actl6b Zfp788 Smarce1 Rsl1 Gata3 Zfp770 Gata1 Znf773 Gata2 Zfp775 Setd1b Yeats4 Setd1a Ring1 Wwtr1 Abl1 Zfp764 ENSRNOG00000066901 Zfp763 Tp73 Jmy Ccnd2 Zfp111 Phc2 Zfp113 Nr3c2 Cbx6 Zfp597 Nr3c1 Ccnd3 Znf750 Phc1 Tgif1 Cbx4 Tgif2 Cbfb Zfp599 Ccnd1 Nr1d2 Cbx2 Nr1d1 Vdr Esr1 Zfp583 Phc3 Zfp101 Kmt2d Dyrk2 Crebbp Ndufa4 L3mbtl2 Cdk7 Iws1 Daxx Cdk6 Dek Kmt2a Trim33 Kmt2b Znf740 Kmt2c Zfp566 H2ac18 Ing2 Zfp324 Ppara Tcf3 Bax Sin3a LOC120095871 Nr1i3 Sin3b Zfp954 Csnk2a2 Zfp951 Ctsk Trim28 Zfp790l2 Ctsl Zfp710 Csnk2a1 Pcgf2 Rnmt Zfp952 Srrt Bmi1 Thrb Znf18 Mnat1 Thra Zfp719 Pbrm1 Prdx2 Brd7 Prmt6 Prdx5 Hist1h2bq Zfp704 Prmt1 Zfp945 Smarcb1 Zfp703 Hdac1 Nr5a1 Zfp706 Wdr5 Zfp948 Ash2l ENSRNOG00000070049 Yaf2 Prdx1 L3mbtl1 Csnk2b Pax5 Tp53bp2 H2aj Taf9 Taf9b Nrbf2 Tfap2c Elf1 Nrbf2l1 Tfap2a Taf15 Elf2 Tead4 Tal1 Tfap2b Taf11 Zfp758 Smarca2 Taf10 Zscan25 Smarca4 Taf13 Zscan22 Foxp3 Taf12 Pou2f2 H3-3b Tbp Zfp746 Yap1 Taf4b Krba1 Hist3h2ba Taf7l-ps1 Ep300 Pcgf6 Gtf2a1 Noc2l Gtf2a2 Rnf2 Tead3 Gtf2b ENSRNOG00000068602 Ski Itch Taf8 Tead2 Smarcd1 Taf7 Tcf12 Tigar Taf6 Zfp964 Smarcd3 Taf5 Pcgf5 Hipk1 Gtf2e1 Cox6a1 Smarcd2 Taf4 Cox6a2 Ptpn11 Taf2 Zfp286a H2bc18 Taf1 Rabggta Runx1 Gtf2e2 Kat2b Rabggtb Ppp1r13l H2az2 Ppp1r13b Rbbp5 Zfp119bl H2bc4 Max Hist1h4m H2bc1 Cox6c2 Pml Cnot3 Smarcc1 Cnot2 Hist1h2ai Cnot1 Nek4 Pip4k2b Cnot7 Pip4k2c Cnot6 Pip4k2a Cnot4 Rorc Cnot9 Rorb Foxo6 Cnot8 Ints13 Ints14 Sgk1 Cox6b1 Nr4a1 Ints11 Cox6b2 Ints12 Rictor Ints10 Zc3h8 Rngtt Foxg1 Prr5 Rprd2 G6pdx Casp2 Mga Zfp37-ps1 Mapkap1 Tbx5 E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 Nr6a1 Zfp496 Zfp808l3 Prkaa1 Pip4p1 Eaf1 Prkaa2 Eaf2 Zfp483 Cox8a Rpap2 Cox8c Zfp248 Nuak1 Hnf4a Cox7b Foxo1 Hnf4g Cox7c Zkscan8 Prkag3 Zkscan7 Prkag1 Zkscan1 Prkag2 Zkscan4 Zkscan5 Zkscan3 Bnip3l Nr4a3 Nr4a2 Mapkapk5 Ezh2 Zfp955a Zfp955b Bmal1 Nrif1 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%10225383 Regulation of CDH11 Expression and Function Zeb2 Jup Ctnnd1 Ctnnb1 Sp1 Cdh11 Amot Adam19 Angptl4 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%10223827 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Pxn Itgb1 Parva Ilk RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-RNO-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 Parg Polb Fen1 Pole Parp2 Parp1 Rfc5 Pold2 Apex1 Adprs Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pold3 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-RNO-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Bckdhb Dld Bckdha Dbt TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222097 Tyrosine catabolism Hpd Fah Hgd Tat Gstz1 DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 96%10223161 Digestion of dietary lipid Cel Pnliprp2 Pnliprp1 Lipf Clps Pnlip UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-RNO-9758881.1 Uptake of dietary cobalamins into enterocytes Cblif Cubn Amn SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-373755.1 Semaphorin interactions Rhoc Cd72 Erbb2 Plxnb3 Sema6d Gsk3b Crmp1 Plxna4 Plxna3 Plxna2 Rras Met Tyrobp Sema4a Dpysl3 Dpysl4 Dpysl5 Arhgap35 Plxnc1 Tln1 Sema3a Sema7a Fes Trem2 Sema3e Plxna1 Cdk5r1 Rock2 Rock1 Plxnd1 Rac1 Pak1 Rnd1 Pak3 Farp2 Pak2 Cdk5 Pip5k1c Sema5a Arhgef11 Ptprc Rhoa Hsp90aa1 Arhgef12 Fyn Limk1 Sema4d Plxnb1 Nrp1 Hsp90ab1 Rhob Dpysl2 SUMOYLATION%REACTOME DATABASE ID RELEASE 96%10224493 SUMOylation Nup133 Nup210 Suz12 Nup155 Nup153 Mrtfa Senp5 Senp5l1 Sumo2 Senp2 Ctbp1 Blm Nop58 Ikbkg Pias4 Ube2i Nfkb2 Rela Hdac2 Parp1 Hdac4 Pcna Xrcc4 Nfkbia Ikbke Tp53bp1 Nr1i2 Smc6 Smc5 Smc3 Pias3 Senp1 Ddx17 Sp140 Pias1 Pias2 Ring1 Nsmce4a Casp8ap2 Hic1 Eid3 Herc2 Uhrf2 Phc2 Rnf168 Nr3c2 Sumo1 Cetn2 Nr3c1 Nsmce1 Phc1 Nsmce2 Cbx4 Sumo3 Xpc Zfp131 Sp3 Cbx2 Vdr Esr1 Stag2 Phc3 Stag1 Dnmt1 L3mbtl2 Nr1h4 Daxx Rad52 Safb Mageb10 Sp100 Ing2 Ppara Sin3a Top2b Top2a Top1 Trim28 Trim27 Uba2 Pcgf2 Rwdd2b Bmi1 Thrb Sae1 Thra Brca1 Mbd1 Satb2 Satb1 Park7 Smc1a Hdac1 Nr5a1 Tfap2c Ep300 Nrip1 Rnf2 Mitf Tdg Mta1 Nr1h3 Nr1h2 Hist1h4m Rxra Pml Vhl Pgr Cdca8 Incenp Aurkb Rpa1 Nup93 Nup50 Nup35 Rara Nup54 Nup98 Npm1 Nup58 Rangap1 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Hnrnpc Nup85 Nup42 Hnrnpk Nr5a2 Nup62 Nup43 Nup88 Birc5 Ar Aaas Ranbp2 Nup214 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins Alox5 Alox15 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-RNO-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors Hsp90b1 Jchain Hpx Alb Prdx1 Hp Cd163 Apoa1 Apoe LOC120093819 Ambp Apob Lrp1 Apol7al1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 Apol2 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 Msr1 ENSRNOG00000066926 Calr Apol7bl1 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 Scarb1 ENSRNOG00000070192 Cd36 S100a9 Iglc1 ENSRNOG00000070159 Hba1 ENSRNOG00000071049 Hbb AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Stab1 ENSRNOG00000067679 ENSRNOG00000070832 Hmgb1-ps34 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 Sparc ENSRNOG00000066904 ENSRNOG00000063713 Apol9a ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 Hmgb1l2 ENSRNOG00000069940 Hmgb1l1 ENSRNOG00000067643 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-RNO-9634815.1 Transcriptional Regulation by NPAS4 Maged1 Npas4 Arnt2 Bmal1 Arnt NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism Naprt Slc22a13 Naxe Naxd Nmnat3 Nmnat2 Qprt Nadk2 Slc25a51 Nudt12 Nmrk1 Slc5a8 Bst1 Cd38 Nadsyn1 Nadk Nmnat1 Rnls Nt5e Nampt ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 96%10221983 Activation of ATR in response to replication stress Cdc6 Mcm7 Mcm8 Dbf4 Hus1 Atrip Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Chek1 Rad9a Rpa1 Rad9b Rpa2 Rpa3 Rad1 Clspn Rad17 Rfc5 Rfc3 Rfc4 Cdc25c Rfc2 Cdk2 Atr Cdc25a Orc4 Orc6 Orc1 Orc3 Orc2 Cdc7 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10222083 Fatty acid metabolism Phyh Amacr Eci2 Akr1c18 Abcc1 Akr1c12l1 Akr1c19 Hacl1 Hsd17b3 Akr1c21 Mlycd Scp2 Prkab2 Crat Acox1 Hsd17b12 Acox2 Ggt1 Ehhadh Acox3 Ggt5 Akr1c3l1 Akr1c12 Hpgds Akr1c1 Akr1c13 Acaa1b Hsd17b4 Akr1c9 Hao2 Pecr Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Nudt19 Acot1 Acot2 Acot5 Acot3 Acot4 Acot8 Abcd1 Echs1 Cyp1b1 Hadh Eci1 Cbr1 Acadm Decr1 Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Pon3 Pon1 Mecr Mapkapk2 Morc2 Gpx2 Aloxe3 Gpx1 Alox12b Hadha Hadhb Acadl Cyp8b1 Cyp2u1 Hacd1 Hacd2 Ltc4s Hacd3 Hacd4 Hsd17b8 Dpep1 Dpep2 Mcat Them4 Acad11 Elovl2 Acly Elovl3 Acaa2 Elovl5 Elovl1 Elovl6 Elovl7 Tecrl Faah Acbd6 Acbd4 Ppt2 Ppt1 Acsf3 Acsf2 Dbi Acot11 Scd1 Acot12 Acot13 Them5 Acot9 Acot7 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 Rxra Fads2 Pon2 Acoxl Fads1 Acadvl Alox15b Alox12 Cbr4 Tecr Alox5ap Acsbg1 Gpx4 Pctp Acads Alox5 Acsbg2 Lta4h Ndufab1 Acaca Alox15 Cyp2c66 Fasn Cyp2c11 Cyp1a1 Ephx2 Cyp1a2 Slc22a5 Awat1 Ptgs2 Mmut Pcca Ppard Pccb Ptges3 Prkaa2 Cyp2j16 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Pla2g4a Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Prkag2 Cpt1a Mid1ip1 Cyp4f4 Thrsp Cpt2 Cyp4a10 Cyp4a2 Mmaa Cpt1b Slc25a20 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-RNO-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) Srebf1 Mbtps1 Scap Ran Kpnb1 Srebf2 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina Lmna Lmnb1 Casp6 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-RNO-1280215.1 Cytokine Signaling in Immune system Ube2d3 Ube2d2 Ybx1 Creb1 Stx1a Mapk3 Rps6ka5 Nras Grb2 Tnfsf13 Fyn Kras Sos1 Tyk2 Hras Vamp2 Nkiras1 Eda Tnfrsf4 App Tnfrsf8 Mapk9 Atf2 Tnfrsf1b Ikbkb Edar Atf1 Tnfrsf11b Tnfrsf11a Mapk7 Nkiras2 Cd40lg Il6st Tnfsf4 Mapk8 Traf6 Cd40 Peli1 Tnfsf13b Ikbkg Ppp2r5a Tnfsf11 Map3k8 Tnfsf8 Map3k7 Tnfsf9 Ube2n Relb Tnfrsf9 Lrrc14 Nfkb2 Brwd1 Lta Tslp Nfkb1 Ltb Tnfrsf17 Traf2 Il7 Edaradd Il7r Tnf Fbxw11 Tnfsf15 Fos Tnfsf14 Tnfrsf1a Vrk3 Tnfsf12 Alpk1 Tnfrsf13c Rela Tnfsf18 Rps6ka3 Ltbr Tnfrsf25 Peli2 Eda2r Tnfrsf18 Rps6ka1 Peli3 Tnfrsf12a Map3k14 Tifa Irs1 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Kpnb1 Hmgb1-ps34 Dusp4 Kpna1 Ripk2 N4bp1 Dusp7 Tec Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Il6 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Il6r Map2k3 Usp14 Tab3 Tab2 Fnta Usp18 Tab1 Fntb Nlrc5 Chuk Mapk10 Ifi44 Mapk11 Ifi44l Flt3 Furin Grb10 Il1rapl1 Akt3 Akt2 Akt1 Vamp7 Hspa8 Prkra Sh2b1 Tarbp2 Stxbp2 Crk Stx4 Nedd4 Ube2l6 Lyn Yes1 Camk2g Camk2d Camk2b Camk2a Il34 Ptprz1 Il16 Txlna Csf1r Stx3 Eloc Elob Ube2m Il18 Cd4 Lck Ifng Ifngr2 Ifngr1 Raf1 Jak2 Ctsg Uba7 Sumo1 Birc2 Uba3 Cul5 Inpp5d Canx Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Csf1 Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Inppl1 Pik3cd Sfn Irs2 Traf3 Ywhaz Csf3 Hspa1b Hspa1a Crkl Rapgef1 P4hb Il1rl2 Il1f10 Gsdmd Il36a Il36rn Il36g Il18rap Il18r1 Il18bp Sdc1 Ptpn1 Tbk1 Irf3 Mavs Rig1 Plcg1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Eif2ak2 Sphk1 Psmb1 Fancl Psmb3 Fancm Psmb2 Pim1 Uba52 Fanca Fancb Fancc Mapt Ube2d1 Fance Fancf Cntf Btrc Fancg Cntfr Psma7 Nck1 Gbp5 Ifnlr1 Clcf1 Pde12 Ctf1 Ilf2 Psmc5 Il20rb Actb Psmc2 Il20ra Dus2 Psmc1 Ilf3 Il31ra Psmc4 Flnb Lif Snca Psmc3 Il10 Dhx9 Il11 Ppm1b Il22ra2 Osmr Mx2 Arih1 Il10rb Pggt1b Il10ra Il22 Trim25 Ptpn2 Il11ra1 Ubb Hspa1l Il20 Il24 Ubc Gbp2 Foxo3 Osm Gbp1 Il22ra1 Ube2e1 Gbp3 Psmb6l1 Faap100 Lifr Npm1 Ifnl1 Psmd7 Casp1 Ifnl3 Oasl Psmd6 Hspa2 Psmd8 Faap24 Fkbp5 Isg15 Psmd2 Faap20 Psmd1 Adrm1 Cul1 Cdk1 Becn1 Mapk1 Il12rb1 Il12rb2 Ebi3 Il12b Il27 Il23a Il12a Crlf1 Ppp2cb Ppp2ca Il23r Prkaca Prkcd Ghr Gh1 Prl Il33 Prlr Ppp2r5d Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Ppp2r1b Il1b Il1r2 Ppp2r1a Il1r1 Tp53 Snap25 Adar Pias1 Socs1 Il13ra2 Il4r Stat6 Il13 Hsp90b1 Socs5 Il4 Stat3 Stat1 Il15 Il15ra Il9 Il21 Actg1 Ptk2b Stat5a Stat5b Il9r Ifnar1 LOC120103158 Smarca4 LOC120103159 Ifnar2 Ifnb1 Rnasel Sqstm1 Ifna4 Ifna1 Ifna1l1 Ifna4l1 Irf9 Vav1 Ptpn11 H2bc18 Sos2 Syk Hck Il1rl1 Casp3 Myd88 Rbx1 Socs3 Cbl NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) LOC120093247 Ppp2ca Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Magohb Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Ppp2r1a Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Ncbp2 Ncbp1 Rpl23a Upf3b Upf3a Eif4a3 Smg1 Smg9 Smg8 Smg7 Smg6 Smg5 Upf1 Upf2 Rbm8a Casc3 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Pabpc1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Ppp2r2a Rps4x-ps13 Rpl38 Rps3a Etf1 Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Pnrc2 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rnps1 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Magoh Rpl12-ps1 Ubc Rps20 Rps21 Dcp1a Rpl22 Rps23 Rps24 Rpl23 Gspt2 Gspt1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-RNO-174113.1 SCF-beta-TrCP mediated degradation of Emi1 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fbxo5 Fzr1 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins Furin Pcsk5 Ngf Pcsk6 TRIGLYCERIDE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222301 Triglyceride metabolism Fabp1 Fabp2 Fabp3 Fabp4 Gk Fabp7 Mogat1 Fabp6 Pnpla5 Gpat2 Pnpla4 Mogat2 FABP12 Gpam Gpd2 Agmo Fabp9 Fabp5 Dgat2 Gykl1 Dgat1 Lpin3 Lpin2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway Rpe Taldo1 Prps1l3 Pgd Prps1 G6pdx Rpia Dera Prps2 Shpk Pgm2 Pgls Tkt Rbks DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions Clec5a Siglec15 Siglec10 Klrd1 Klrc2 Klrk1 Klrc1 Tyrobp Syk Plcg1 Trem2 Trem1 Sirpa B2m Lck Plcg2 Grap2 Pik3ca Shc1 Rac1 Pik3r1 Pik3cb Nras Vav3 Grb2 Pik3r2 Fyn Btk Kras Vav2 Sos1 Hras Lat Lcp2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-RNO-109606.1 Intrinsic Pathway for Apoptosis Ywhag Gsdme Casp7 Apip Gsdmd Diablol1 Apaf1 Ppp3cc Pmaip1 Bax Septin4 Bak1 Bad Casp3 Nmt1 Gzmb Bid Casp9 Xiap Ppp3r1 Ywhae Casp8 Bcl2l11 Cycsl2 Mapk3 Mapk1 Dynll1 Dynll2 Bcl2l1 Bmf Ywhaq Ywhah Cycs Sfn Ywhab Mapk8 Ywhaz RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) Neil2 Lig3 Pnkp Neil1 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 Parg Polb Fen1 Mpg Pole Ogg1 Parp2 Parp1 Rfc5 Mutyh Pold2 Apex1 Adprs Pold1 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Rfc2 Pold4 Pold3 Mbd4 Smug1 Nthl1 Tdg Ung ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223739 Adenosine P1 receptors Adora2b Adora2a Adora1 Adora3 JOSEPHIN DOMAIN DUBS%REACTOME%R-RNO-5689877.1 Josephin domain DUBs Rps27a Rad23a Rad23b Atxn3 Josd2 Uba52 Josd1 Ubb Ubc Prkn Vcp ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-RNO-1300645.1 Acrosome Reaction and Sperm:Oocyte Membrane Binding Izumo1 Cd9 Acr Izumo4 Izumo3 Izumo2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-RNO-174184.1 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdc16 Cdk1 CHROMOSOME MAINTENANCE%REACTOME%R-RNO-73886.1 Chromosome Maintenance Itgb3bp Rsf1 Oip5 Mis18a Rbbp4 Rbbp7 Cenpw H2ac18 Hist1h2bq Terf2 Acd Terf1 Ruvbl1 H2aj Terf2ip Tinf2 Pot1 Ccna1 Ccna2 Hist3h2ba Ppp6r3 ENSRNOG00000068602 Knl1 Chtf8 Ppp6c Blm Wrn Chtf18 H2az2 Tert Ctc1 Stn1 H2bc4 Hist1h4m Ten1 Dscc1 H2bc1 Dna2 Shq1 Hist1h2ai Dkc1 Nhp2 Pif1 Gar1 Wrap53 Rtel1 Nop10 Cenpc Cenpa Cenpu Cenpt Cenpq Rpa1 Cenpp Ankrd28 Rpa2 Cenpo Cenpn Cenpm Rpa3 Cenpl Cenpk Cenpi Lig1 Cenph Npm1 Fen1 Rfc5 Pold2 Pold1 H2ab2 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Cdk2 H2ac4 Pola1 Pold4 Pold3 Prim2 Prim1 Mis18bp1 Hjurp Smarca5 ENSRNOG00000066901 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-RNO-349425.1 Autodegradation of the E3 ubiquitin ligase COP1 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Tp53 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Atm Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Psmb5 Psmb4 Psmb7 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins Pex5 Ube2n Leo1 Uba52 Ube2d1 Rnf181 Shprh Rad18 Rnf152 Rnf40 Rnf144a Hltf Wac Pex14 Ube2v2 Pex13 Ube2b Pex12 Ube2d3 Pex10 Ube2d2 Hist1h2bq Ube2a Ubb Prkdc Ubc Bcl10 Ube2e1 Skic8 Pcna Rnf20 Ctr9 Cdc73 Paf1 Rps27a Pex2 Rraga Ube2l3 ENSRNOG00000066901 H2bc4 H2bc1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222875 TAK1-dependent IKK and NF-kappa-B activation Ikbkg Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Alpk1 Rela Tifa S100b Ubb Hmgb1-ps34 Ubc N4bp1 Casp8 Nfkbib Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Rps27a Usp14 Tab3 Tab2 Usp18 Tab1 Nkiras1 Nlrc5 App Chuk Ikbkb Nkiras2 Traf6 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation Iws1 Cdk7 Ell Ccnk Tcea1 Ccnt2 Ssrp1 Eloa2l Mnat1 Eloa Aff4 Supt6h Cdc73 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Mllt3 Ncbp2 Mllt1 Ncbp1 Gtf2h2 Leo1 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Cdk9 Skic8 Eaf1 Eaf2 Ccnh Ctr9 Paf1 LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance Ldlrap1 Lipa Cltc Soat2 Soat1 Npc2 Npc1 Ldlr Ap2s1 Apob Ap2a2 Ap2a1 Ap2b1 Pcsk9 Nceh1 Ap2m1 Clta CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Eif5 Rps14 Eif2b3 Rps15 Eif2b2 Rps16 Eif2s3 Rps17 Eif2b5 Rpl4 Rps15a Eif2b4 Rpl5 Rps18 Eif2s2 Rpl3 Rps19 Eif2b1 Rps27 Pabpc1 Eif2s1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Eif4h Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Eif4a2 Eif4a1 Eif5b Fau Eif4ebp1 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 Eif4e TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-RNO-446107.1 Type I hemidesmosome assembly Plec Megf11 Dst Itga6 Cd151 Itgb4 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223943 Presynaptic function of Kainate receptors Grik3 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%10223767 Sodium Calcium exchangers Slc8a1 Slc24a4 Slc8a2 Slc24a3 Slc24a2 Slc8a3 Slc24a1 Calm3 Slc8b1 Sri Slc24a5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224161 SHC1 events in ERBB4 signaling Grb2 Kras Shc1 Sos1 Ereg Hras Nrg2 Nrg3 Hbegf Btc Nras ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%10224453 Antagonism of Activin by Follistatin Fstl3 Fst Inhba Inhbb NUCLEOTIDE METABOLISM%REACTOME%R-RNO-15869.1 Nucleotide metabolism Itpa Dnph1 Nudt5 Atic Adsl Ppat Adss2 Pfas Paics Gart Adss1 Cda Umps Cad Samhd1 Pudp Dhodh Tk2 Uck1 Uck2 Dguok Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Adk Rrm2b Gmpr Txnrd1 Hprt1 Dck Dtymk Nudt13 Aprt Dut Ada Rrm1 Tyms Rrm2 Ak1 Gsr Nme3 Ak2 Nme2 Ak5 Glrx Ak4 Ak7 Ak6 Ak9 Nme1 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 Tymp Upb1 Upp1 Nt5c3a Upp2 Dpys Dpyd Nt5m Gmps Impdh2 Impdh1 Txn Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 Xdh Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-RNO-112409.1 RAF-independent MAPK1 3 activation Dusp7 Dusp6 Jak2 Dusp2 Pea15 Dusp5 Dusp1 Dusp9 Dusp8 Il6 Mapk3 Dusp16 Map2k2 Cdk1 Il6r Map2k1 Mapk1 Dusp10 ENSRNOG00000069024 Tyk2 Ptpn11 Il6st Dusp4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 96%10223707 EGFR Transactivation by Gastrin Mmp3 Grb2 Egfr Kras Sos1 Hras Hbegf Nras Prkca NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 96%10224497 Nuclear Pore Complex (NPC) Disassembly Nup133 Ccnb1 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Cdk1 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Ccnb2-ps2 Nup43 Nup88 Aaas Ccnb2 Ranbp2 Nup214 RHOQ GTPASE CYCLE%REACTOME%R-RNO-9013406.1 RHOQ GTPase cycle Ophn1 Gopc Rhoq Arhgap35 Mpp7 Srgap2 Vamp3 Cdc42ep1 Plekhg3 Cdc42ep4 Syde1 Dlc1 Arhgef7 Scrib Snap23 Arhgap32 Pak1 Cav1 Git1 Pak2 Fnbp1 Steap3 Itsn1 Tfrc Trip10 Wwp2 Pak4 Git2 Obscn Slc1a5 Arhgef9 Prex1 Jup Arhgap5 Arhgap17 Arhgap1 Stom Rab7a Gja1 Arhgap33 Cdc42bpa Cdc42bpb Slc4a7 Iqgap3 Diaph3 Arl13b Cdc42ep2 Depdc1b Cdc42ep3 Lamtor1 Cpne8 Cdc42 Arhgap21 Arhgap26 Cftr REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10224937 Regulation of PTEN stability and activity Nedd4 Prex2 Csnk2a2 Trim27 Csnk2a1 Tnks2 Xiap Csnk2b Mkrn1 Psma4 Psma3 Akt3 Akt2 Akt1 Psma6 Psma5 Psma2 Stub1 Rnf146 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Tnks Psmd13 Wwp2 Otud3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Pten Psma7 Usp13 Psmc5 Frk Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222339 mitochondrial fatty acid beta-oxidation of saturated fatty acids Acadm Acadvl Hadha Hadhb Acadl Echs1 Hadh Acads Mecr COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224975 COPI-independent Golgi-to-ER retrograde traffic Agpat3 Dync1h1 Actr1a Pafah1b3 Pafah1b2 Dctn1 Actr10 Dctn2 Dync1i2 Dctn4 Dync1i1 Rab18 Galnt1 Galnt2 Pla2g6 Dync1li2 Dync1li1 Pla2g4a Dynll1 Dynll2 Pafah1b1 Rab3gap2 Rab3gap1 Rab6b Rab6a Bicd2 Bicd1 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-RNO-9855719.1 Regulation of FXIIa and plasma kallikrein activity Kng1 F12 Serping1 C1qbp A2m Hrg Krt1 Klkb1 Plaur AZATHIOPRINE ADME%REACTOME%R-RNO-9748787.1 Azathioprine ADME Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Rac1 Hprt1 Xdh Vav3 Nme2 Slc28a3 Vav1 Slc28a2 Vav2 Gmps Nme1 Abcc5 Impdh2 Tpmt Impdh1 Slc29a2 Abcc4 Slc29a1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%10223915 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation Map3k7 Uba52 Irak2 Rps27a Tab3 Tab2 Tab1 Ly96 Ticam2 Ubb Ubc Ticam1 Cd14 Traf6 Tlr4 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity Sin3a Hdac2 Lbr Hdac1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%10225091 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Ctsk Ctsl Serpinb13 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling Kat2a Runx3 Maml3 Rbpj Maml1 Crebbp Maml2 Kat2b Ep300 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-RNO-9018676.1 Biosynthesis of D-series resolvins Gpx4 Hpgd Alox5 Lta4h FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf19 Klb Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 96%10223745 RHO GTPases Activate ROCKs Rhoc Rhob Rock2 Rock1 Rhoa CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%10225109 Cristae formation Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Mt-atp6 Atp5mc1 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%10225387 Regulation of Homotypic Cell-Cell Adhesion Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Src Fyn Ctbp1 Ctsb Cbll1 Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Angptl4 Vcl Hdac2 H2ab2 Twist1 Kmt5a H2ac4 Sec11c Amot Sec11a Prkcsh Sirt1 Zmym2 Sp1 ENSRNOG00000066901 Pomt1 Dnttip1 Pomt2 Furin Pcsk7 Pcsk6 H2ac18 Adam19 Ctbp2 Csnk2a2 Ctsl Zeb1 Csnk2a1 Zeb2 Hist1h2bq Hdac1 Cdh11 Ganab Csnk2b Mphosph8 H2aj Canx Arhgap32 Spcs3 Spcs1 Spcs2 Psma4 Smarca4 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Ezh2 Dad1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-RNO-5656121.1 Translesion synthesis by POLI Rev1 Rev3l Poli Rfc5 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Rps27a Rpa1 Rpa2 Ubb Rpa3 Ubc Mad2l2 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 96%10225001 AURKA Activation by TPX2 Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Aurka Nde1 Nedd1 Haus7 Tpx2 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-RNO-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA Dld Dhtkd1 Dlst REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-RNO-9617629.1 Regulation of FOXO transcriptional activity by acetylation Foxo1 Sirt3 Sirt1 Crebbp Kat2b Ep300 Foxo3 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%10224815 Negative regulation of MAPK pathway Ppp2r5b Ppp2r5a Ppp2cb Dusp2 Ppp2ca Ksr1 Dusp5 Uba52 Paqr3 Dusp1 Dusp9 Araf Dusp8 Dusp16 Ptpn7 Map2k2 Ptpn3 Ppp2r5e Map2k1 Dusp10 Mapk12 ENSRNOG00000069024 Pebp1 Ppp2r5d Ubb Ubc Dusp4 Brap Dusp7 Dusp6 Raf1 Braf Ppp2r1b Ppp2r1a Mark3 Mapk3 Nras Mapk1 Rps27a Kras Hras Ppp5c Ywhab UREA CYCLE%REACTOME%R-RNO-70635.1 Urea cycle Nags Slc25a2 Sirt5 Cps1 Arg2 Arg1 Slc25a15 Asl Otc RRNA PROCESSING%REACTOME%R-RNO-72312.1 rRNA processing LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Utp18 Wdr43 Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Rpl35al8 Ddx49 Wdr36 Rpl22l1 Rplp0 Ddx47 Rplp1 Rpl13a Rpl35al2 Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Mphosph6 Nol9 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rpl10a Exosc9 Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Rps2 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Csnk1d Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Las1l Rps27 Ltv1 Rpsa Rpl35 Rps10 Fcf1 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rrp9 Rps8 Rpl6 Rps5 Pwp2 Rpl7 Rps26-ps13 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rpl24 Rpl26 Rps3 Imp4 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rpp25 Rps29 Rpl12-ps1 Ubc Rps20 Ncl Rps21 Rpl22 Rps23 Xrn2 Rps24 Rpl23 Snu13 Wdr75 Senp3 Fau Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Pdcd11 Pno1 Rpl27a Rpl31l15 Utp20 Nop14 Pelp1 Rcl1 Utp25 Tbl3 Nol11 Rps6 Rpp40 LOC100910714 LOC102551819 Wdr3 Bud23 Dcaf13 Csnk1e Utp15 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%10223035 PI-3K cascade:FGFR3 Fgf16 Fgf17 Pik3ca Fgf18 Frs2 Pik3r1 Grb2 Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 Gab1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%10223967 Ovarian tumor domain proteases Ikbkg Uba52 Esr1 Pten Apc Ube2d1 Tnip2 Nod2 Nod1 Ubb Ubc Tp53 Ripk2 Yod1 Otub1 Rhoa Cdk1 Vcp Ripk1 Rps27a Otud7a Otub2 Otud7b Vcpip1 Traf3 Tnip3 Rnf128 Tnip1 Otud3 Zranb1 Traf6 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-RNO-1663150.1 The activation of arylsulfatases Sts Arsl Arsk Arsa Arsj Arsi Arsg Sumf1 Arsb Sumf2 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%10222233 IGF1R signaling cascade Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Igf1r Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Igf2 Fgfr2 Fgf16 Them4 Igf1 Pde3b Tlr9 Fgf17 Pik3ca Shc1 Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Sos1 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 KETONE BODY METABOLISM%REACTOME%R-RNO-74182.1 Ketone body metabolism Hmgcl Oxct2a Acss3 Bdh2 Bdh1 Oxct1 Hmgcll1 Acat1 Hmgcs2 Aacs DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%10221937 DNA strand elongation Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Gins2 Gins1 Gins4 Gins3 Rpa3 Lig1 Dna2 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME%R-RNO-9648025.1 EML4 and NUDC in mitotic spindle formation Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Pafah1b1 Zw10 Knl1 Eml4 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Ppp2r5b Dync1h1 Ppp2r5a Spc24 Spc25 Xpo1 Nuf2 Mad2l1 Cdca8 Incenp Dync1i2 Bub1b Ndel1 Ppp1cc Dync1i1 Cenpc Cenpa Aurkb B9d2 Ppp2r5e Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222495 Aquaporin-mediated transport Prkaca Prkacb Avp Aqp10 Aqp12a Myo5b Aqp1 Aqp4 Prkar1a Aqp3 Aqp2 Prkar1b Gng3 Gng5 Gng4 Gng7 Avpr2 Gng8 Gngt1 Prkar2a Prkar2b Gnb2 Gnb1 Gnb4 Gnb3 Rab11a Gnb5 Gng11 Aqp9 Aqp8 Gng10-ps1 Aqp7 Aqp5 Aqp11 Gnas Mip DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-RNO-8932504.1 DAG1 core M2 glycosylations Pomt1 Pomgnt1 Pomt2 Mgat5b Dag1 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450513.1 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Xrn1 Mapkapk2 Dis3 Tnpo1 Exosc9 Exosc8 Exosc5 Zfp36 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Exosc3 Exosc2 Ywhab Dcp1a CELL DIVISION%REACTOME%R-RNO-68884.1 cell division Smc3 Plk1 Stag2 Stag1 Wapl Pds5b Kif23 Pds5a Nipbl Mau2 Smc1a Kif20a VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%10224715 VxPx cargo-targeting to cilium Exoc3 Exoc4 Rho Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Arf4 Cnga4 Cnga2 Gbf1 Rab11a Pkd1 Rab8a Asap1 Thoc2l Cngb1 Rab3ip RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport Cox5a Nfs1 Cox5b Higd1c Cox4i1 Cox4i2 Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Uqcrfs1 Nubpl Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Cyc1 Ndufv2 Slc25a18 Cox7a1 Ndufv1 Slc25a22 Cox7a2 Ndufv3 Uqcrb Fxn LOC120097699 Uqcrh Ndufc2 Ndufa12 Ndufa11 Ndufa10 Ndufs1 Ecsit Timmdc1 Ndufa13 Cox7a2l Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa6 Hscb Ndufa9 Ndufb8 Ndufs3 Ndufa8 Ndufb11 Ndufb10 Ndufb1 Lyrm7 Ndufb3 Rnf113a1 Hccs Uqcrc2 Uqcrc1 Etfb Lyrm4 Ndufb5 Etfa Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Uqcr10 Ttc19 Cycsl2 Hspa9 Cox18 Tmem177 Cox20 Cycs Ndufa4 Mt-cyb Got2 Ndufa5 Cox6a1 Cox6a2 Cox6c2 Ndufab1 Cox6b1 Cox6b2 Mt-co3 Got1 Mt-co2 Mdh1 Cox8a Mdh2 Slc25a11 Cox8c Slc25a12 Slc25a13 Cox7b Cox7c Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling Tnfsf10 Casp8 Fadd Cflar CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway Casp8 Il1b Pycard Malt1 RHOH GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225179 RHOH GTPase cycle Mtr Pak6 Pak4 Slc1a5 Pak5 Dbt Tmem59 Zap70 Csk Vamp3 Jup Lck Osbpl11 Stom Uaca Rock2 Rab7a Nsfl1c Rock1 Fam91a1 Pak1 Cav1 Arhgdig Pak2 Arhgdib Slc4a7 Vcp Ralgapa1 Lamtor1 Tfrc Nipsnap2 Wdr11 Tuba1b Arhgdia Rhoh DARPP-32 EVENTS%REACTOME%R-RNO-180024.1 DARPP-32 events Ppp1ca Pde4d Ppp2cb Ppp2ca Prkar2a Prkar2b Pde4a Pde4b Ppp2r1b Prkaca Ppp2r1a Prkacb Cdk5 Prkar1a Prkar1b Ppp1r1b Ppp2r5d Pde4c REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 96%10224535 Regulation of TP53 Activity through Methylation L3mbtl1 Uba52 Prmt5 Ttc5 Ehmt1 Kmt5a Atm Ep300 Rps27a Chek2 Mdm4 Ubb Jmy Ubc Tp53 Smyd2 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225249 RSK activation Rps6ka1 Rps6ka6 Rps6ka2 Rps6ka3 NGF-STIMULATED TRANSCRIPTION%REACTOME%R-RNO-9031628.1 NGF-stimulated transcription Creb1 Chd4 Nab2 Egr2 Sgk1 Srf FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Fbxl7 Psma7 Aurka Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%10224659 CHD chromatin remodelers Sf3b1 Sf3b3 Sf3b4 Sf3b5 Snrpepl2 Ctnnb1 Rbbp4 Rbbp7 H2ac18 Ssrp1 Hist1h2bq Hdac1 Wdr5 H2aj Snrpn Cherp Rbm17 Ddx46 H3-3b Hist3h2ba Ddx42 Cdc73 ENSRNOG00000068602 Chd3 Chd4 Mbd2 Mta1 H2bc18 Mta2 Mta3 Mbd3 H2az2 Cbx3 Chd8 H2bc4 Hist1h4m H2bc1 Gatad2a Gatad2b Hist1h2ai Puf60 Leo1 Ube2i Phf5a Smndc1 U2surp Snrpf Skic8 Snrpg Snrpb Hdac2 Nr2c2 Fam124b H2ab2 Zmynd8 Snrpa1 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp H2ac4 Cbx1 Ctr9 Paf1 Phf6 Zfp592 Ctcf Cdk2ap1 Snrpd1 Nr2f2 Chd1 Chd2 Chd5 Chd6 Chd7 Tcf19 ENSRNOG00000066901 Dhx15 Pwwp2a Snrpd3 Mbd3l1 Sf3a1 Mbd3l2 Sumo1 Sf3a2 Zfp687 Sf3a3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Ywhag Ccnb1 Ywhae Ccna1 Cdc25c Ccna2 Cdk1 Chek2 Ywhaq Ywhah Wee1 Sfn Ywhab Ywhaz DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response Rnf8 Nsd2 Rad50 Eya2 Eya1 Eya4 Babam1 Eya3 Babam2 Ubxn1 Brca1 Hist1h2bq Uimc1 Hist3h2ba Rps27a H2bc4 Hist1h4m Mapk8 H2bc1 Pias4 Ube2n Mre11 Ube2i Uba52 Kat5 Nbn Baz1b Chek2 Ube2v2 Bard1 Ubb Ubc Tp53 Kpna2 Atm Bap1 Tp53bp1 Apbb1 Kdm4b Kdm4a Brcc3 Abl1 Smarca5 ENSRNOG00000066901 Ppp5c Herc2 Rnf168 Sumo1 ABRAXAS1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%10223947 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bad Bcl2l1 Bcl2l11 Bid Pmaip1 G1 PHASE%REACTOME DATABASE ID RELEASE 96%10221949 G1 Phase Ppp2r2a Ppp2cb Ccnd1 Ppp2ca Uba52 Tfdp2 Tfdp1 Cks1b Cdk7 Cdk6 Rbl2 Rbl1 Mnat1 Ubb E2f1 Ubc E2f2 E2f3 E2f4 E2f5 Cdkn1b Jak2 Rb1 Cdkn1c Ppp2r1b Ppp2r1a Lyn Cul1 Ccnh Cdk2 Src Ccne1 Rps27a Ccne2 Ppp2r3b Cdkn2b Cdkn2d Abl1 Skp2 Cdk4 Skp1 Ccnd2 Ptk6 Ccnd3 KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism Oxct2a Bdh1 Oxct1 Acat1 CELL CYCLE, MITOTIC%REACTOME%R-RNO-69278.1 Cell Cycle, Mitotic Ywhag Rbbp4 Mapk3 Emd Ppp2r5b Ppp2r5a Fbxw11 Ppp1cc Ppp1cb Ppp2r5e Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Kpnb1 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Tuba1c Tubal3 Nme7 Rcc1 Cep152 Tuba4a Chmp2b Tubgcp2 Cc2d1b Prkcb Haus4 Spast Tubb2b Haus5 Tubb2a Haus6 Ist1 Pcnt Hdac8 Sfi1 Chmp3 Vrk1 Haus1 Tubgcp6 Chmp7 Tubgcp5 Chmp6 Tubgcp4 Lmna Vps4a Tubgcp3 Sirt2 Cep250 Tuba8 Cep290 Cep78 Chmp4c Cep76 Tuba3b Cep72 Chmp4bl1 Tubb6 Cep164 Cep70 Tubb3 Cpap Tubb1 Tubb5 Banf1 Plk4 Ran Odf2 Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Akt3 Akt2 Akt1 Optn Ccne1 Ccne2 Ppp2r3b Cdkn2b Cdkn2d Cdc25a Orc4 Orc6 Orc1 Rab1b Orc3 Kif23 Orc2 Cdt1 Gmnn Ptk6 Cdc7 Chmp2a Kif20a Cdc6 Ppp2r2a Mcm7 Mcm8 Dbf4 Dyrk1a Tfdp2 Tfdp1 Cks1b Cables1 Lin52 Rbl2 Lin54 Rbl1 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Pole3 Pole2 Pole4 Lin9 Rpa1 Rpa2 Wee1 Lin37 Rpa3 E2f1 E2f2 E2f3 E2f4 E2f5 Cdkn1b Pole Cdkn1c Ywhae Lbr Rab1A Rab8a Akap9 Lyn Src Eml4 Wapl Numa1 Pds5b Pds5a Cdca5 Dna2 Ube2i Firrm Jak2 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Kmt5a Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Sumo1 Fbxl7 Phf8 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Ajuba B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Nup50 Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup54 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Nup58 Rangap1 Nup37 Pkmyt1 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Nup188 Kif2c Dync1li2 Tpr Pmf1 Nup160 Dync1li1 Ahctf1 Rae1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Nup42 Ndc80 Nup62 Nup43 Nup88 Birc5 Aaas Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e Nup214 Spdl1 Nup133 Nup210 Nup155 Bub1 Nup153 Itgb3bp Gtse1 Zwilch Nek9 Ctdnep1 Cnep1r1 Lpin3 Gins2 Lpin2 Gins1 Gins4 Gins3 Phlda1 Ofd1 Esco1 Esco2 Tuba1b Ppp1r12b Ppp1r12a Vrk2 Mastl Arpp19 Hsp90ab1 Ankle2 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 Mapk1 Actr1a Ppp2cb Ppp2ca Dctn1 Dctn2 Prkaca Prkca Ppp2r5d Prkar2b Gorasp1 Ppp2r1b Ppp2r1a Nipbl Ncapd2 Mau2 Ncapg Smc4 Ncaph Smc2 Csnk1d Ccp110 Golga2 Tpx2 Tp53 Lig1 Fen1 Set H2ab2 Rab2a Blzf1 Espl1 Ncaph2 Ccnh Ncapd3 Fkbpl H2ac4 Ncapg2 Gorasp2 Mcph1 Smc3 Bora Foxm1 Ppme1 Lcmt1 Mis18bp1 Hjurp Abl1 ENSRNOG00000066901 Cdc25b Obi1 Ccnd2 Ticrr Ccnd3 Ccnd1 Stag2 Stag1 Cdk7 Cdk6 H2ac18 Csnk2a2 Csnk2a1 Mnat1 Hist1h2bq Smc1a Hdac1 Csnk2b H2aj Hist3h2ba ENSRNOG00000068602 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Rbx1 Cdk4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%10223249 Adaptive Immune System Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Prkcq Magt1 Rbbp4 Rbbp7 Mib2 Rasgrp1 Pdcd1lg2 Prkab2 Prkab1 Ube2d3 Ube2d2 Sptbn2 Nras Grb2 Fyn Rap1a Kras Sos1 Rap1b Hras Ikbkb Kbtbd7 Cd40lg Traf6 Cd40 Ppp2r5b Ikbkg Ppp2r5a Map3k8 Map3k7 Ube2n Nfkb1 Cd36 Fbxw11 Rela Ppp2r5e Map3k14 Btla Ppp3ca Ppp3cb Itk Ube2j2 Nfatc1 Nfatc3 Nfatc2 Ppp3r1 Grap2 Ripk2 Nfkbib Prkcb Nfkbia Kif4b Ap2s1 Kif4a Tab2 Dnm3 Ap2a2 Ap2a1 Chuk Ap2b1 Lat Sh3gl2 Itgav Ywhab Osbpl1a Csk Itgb1 Trib3 Cd81 Kif26a Them4 Kif11 Kif15 Kif5a Kif5b Akt3 Akt2 Akt1 Cd19 Sh3kbp1 Kif22 Kif23 Ap1b1 Kif20a Klc1 Ap1m2 Ap1m1 Kifap3 Vamp8 Ap1s3 Klc4 Ap1s2 Klc3 Klc2 Ap1g1 Kif3b Kif3c Cxadr Plcg2 Rab7a Fkbp1a Mtor Prkg1 Pik3r6 Mlst8 Lrr1 Nedd4 Rnf220 Jaml Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Vamp3 RT1-M6-2 Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 B2m Dcaf1 Itga4 Rnf126 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Rnf111 RT1-M10-ps1 RT1-M10-ps5 Snap23 Siah1 Dzip3 Itpr3 Itpr2 Mkrn1 Ube2g2 Itpr1 Pak1 Ube2g1 Rnf138 RT1-N3 Pak2 Rnf130 Lyn Kbtbd8 Yes1 Fbxw4 Src Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Itgal Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Itgb2 Klhl2 Ube4a Lcp2 Spsb2 RT1-M1-2 Trim9 Spsb1 Trip12 Wwp1 RT1-M1-5 Spsb4 Rt1-ec3 Calr Lrsam1 Eloc Huwe1 Elob Ube2j1 Kctd7 Ube2u Kctd6 Ncf1 Zap70 Ncf2 RT1-Db2 Cd3g Ube2w Ncf4 Cd247 RT1-Db1 Ube2m Cd3e Ube2k Cd3d Rnf182 Trav19 Trem1 Ube2o Ltn1 AC109737.1 Ube2v2 Pdia3 Cd4 RT1-Ha Ube2b Mgrn1 Lck Ube2f Ptpn22 RT1-Ba Trpc1 Ube2a RT1-Bb Stim1 Fbxo10 ENSRNOG00000065955 Fbxo11 Trbv16 Fbxo15 RT1-Da Tap2 Tap1 Fbxo17 Nectin2 Lmo7 Rnf41 Pvr Raf1 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Ctsd Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Herc2 Cd74 Trim71 Klhl25 Rnf19b Ube2e3 Lgmn Ube2e2 Klhl21 Btbd6 Hace1 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Psme2 Fbxl7 Psme1 Lonrf1 Psmb9 Zbtb16 Psmb10 Hspa5 Psmb8 Sell Uba1 Cyba Cybb Uba3 Cul2 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Inpp5d Klhl41 Canx Pik3ca Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Ptpn6 Pja2 Pja1 Arel1 Trim63 Rnf144b Pik3r1 Fbxo2 Pik3cb Asb12 Asb14 Asb13 Pik3r2 Asb16 Pik3r3 Asb15 Asb18 Pik3cd Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Kif18a Trim21 Pik3r5 Vhl Dync1h1 Pik3cg Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Dync1i2 Trim36 Trim32 Dync1i1 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Rchy1 Asb1 Lnx1 Cenpe Sec13 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Smurf1 Dynll1 Dynll2 Ywhaz Pdpk1 Kif3a Cd207 Mrc2 Mrc1 Cd101 Pag1 Ptprc Fyb1 Prkn Stub1 Sar1b Ube2l3 Smurf2 Dapp1 Cd22 Blnk Cd79a Cd79b Ctsb Cbll1 Ctss Dnm2 Rapgef4 Rapgef3 Rasgrp2 Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Ppl Xdh Btk C3 Plcg1 Racgap1 Trem2 Rac1 Pak3 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Btrc Psma7 Nck1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdc16 Rnf123 Siah2 Keap1 Actr1a Siglec10 Ppp2cb Ppp2ca Klrk1 Dctn1 Dctn2 Prkaca Icoslg Prkacb Dctn4 Calm3 Ppp2r5d Sec23a Ppp2r1b Ppp2r1a Ctsc Arf1 Sec31a Pten Actr10 Sec24d Sec24c Sec24b Sec24a Ctsh Malt1 Bcl10 Nfkbie Rel H2ab2 H2ac4 Actr1b Siglec1 Siglec5 Siglec8 LOC100910497 Slamf6 Slamf7 Hcst Kir3dl1 ENSRNOG00000066901 Pilrb2l4 Ctla4 Ifitm1 Ifitm2 Socs1 Ifitm6 Pilrb1l3 Rap1gap Lag3 Pilrb-ps7 Cd160 Ccnd1 ENSRNOG00000070312 Pianp Cd226 Ifitm3-ps2 LOC134481331 Ifi30 Lair1 Kmt2a Rilp Treml2 Kmt2c Treml4 H2ac18 Cd200 Ctse Ctsf Cd1d Csnk2a2 Ctso Ctsk ifitm3 Ctsl Cd34 Csnk2a1 Sipa1 Cd200r1l LOC120093164 Rap1gap2 Cd96 Hist1h2bq RT1-DOa RT1-DOb Crtam Cd8b Wdr5 Cd8a Ash2l Cd300le Cd300ld Csnk2b RT1-DMb Cd300lg H2aj Cd300lf Klrb1a Clec4g Clec2e H3-3b Hist3h2ba ENSRNOG00000068602 Itch Vav1 Ptpn11 H2bc18 ENSRNOG00000069193 H2az2 Rbbp5 AABR07065813.1 ENSRNOG00000062915 H2bc4 Igll1 Hist1h4m ENSRNOG00000065191 H2bc1 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Hist1h2ai ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Fcgr2 Cd28 Syk Icos Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Rictor Cd86 ENSRNOG00000066971 Cd80 ENSRNOG00000063341 ENSRNOG00000065283 Prr5 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Trat1 Igkvl13 Mapkap1 AABR07065812.2 ENSRNOG00000063707 Madcam1 Fcgr1a ENSRNOG00000067679 Ap2m1 ENSRNOG00000070832 ENSRNOG00000064041 Clta Itgb7 ENSRNOG00000064481 Icam1 Ctsa ENSRNOG00000065690 ENSRNOG00000064085 Icam5 ENSRNOG00000066904 Cltc Icam4 ENSRNOG00000063713 Icam2 ENSRNOG00000062820 Dnm1 Rnf185 ENSRNOG00000064886 Prkaa1 ENSRNOG00000064490 Vcam1 ENSRNOG00000066072 Derl3 Prkaa2 AABR07065781.1 Derl2 ENSRNOG00000069901 Stt3b ENSRNOG00000067603 Rbx1 ENSRNOG00000066431 ENSRNOG00000068499 Erlin2 Spop ENSRNOG00000069940 Socs3 Erlin1 ENSRNOG00000067643 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdc42 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-RNO-186712.1 Regulation of beta-cell development Foxo1 Akt3 Akt2 Akt1 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%10222025 Glycogen metabolism Phkg1 Gaa Gbe1 Phkg2 Agl Pygl Pygm Phkb Ppp1r3c Gys1 Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Calm3 Ugp2 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%10223229 Metabolism of folate and pterines Mthfd1 Mthfd2 Folr2 Mthfd2l Dhfr Slc19a1 Aldh1l1 Aldh1l2 Shmt2 Fpgs Mthfs Mthfr Slc25a32 Slc46a1 Mthfd1l Shmt1 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223893 IL-6-type cytokine receptor ligand interactions Lifr Crlf1 Jak2 Cntf Cntfr Clcf1 Ctf1 Il31ra Lif Il11 Tyk2 Osmr Il11ra1 Il6st Osm OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 96%10224631 Oxidative demethylation of DNA Tdg SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%10224257 Synthesis of PS Ptdss1 Ptdss2 CIRCADIAN CLOCK%REACTOME%R-RNO-9909396.1 Circadian clock Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Per2 Per1 Per3 Psmb5 Psmb4 Psmb7 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225175 RHOJ GTPase cycle Ophn1 Rhoj Arhgap32 Pik3r1 Arhgap35 Pik3r2 Prex1 Ocrl Trio Depdc1b Arhgap5 Dock8 Syde1 Arhgap1 Arhgap21 Arhgap26 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10223765 SLC-mediated transport of inorganic anions Slc4a10 Slc26a6 Slc4a2 Slc26a4 Slc4a4 Slc34a1 Slc26a3 Slc4a3 Slc26a9 Slc26a2 Slc4a5 Slc26a1 Slc4a8 Slc26a7 Slc4a9 Slc34a2 Slc4a1 Slc26a11 Slc12a1 Slc5a8 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 Slc34a3 Slc13a4 Slc13a1 Slc4a7 Slc5a5 Slc20a2 Ahcyl2 Slc20a1 Slc17a1 SENSORY PERCEPTION%REACTOME DATABASE ID RELEASE 96%10222207 Sensory Perception Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Calm3 Nmt1 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Gngt1 Itpr3 Gnat3 Apoc2 Apoa1 Gnb1 Apoc3 Apoa2 Gnb3 Apoe Gnb5 Apoa4 Apob Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Rdh12 Gpc6 Clps Cyp4v2 Stra6 Pnlip Rpe65 Akr1b10 Rbp4 Rbp3 Myo7a Apom Rbp2 Rlbp1 Rbp1 Sdc1 Lrat Tas2r119 Opn1sw Tas2r39 Tas2r38 Tas1r2 Tas1r1 Fnta Tas2r120 Fntb Tas1r3 Cngb1 Tas2r16 Tas2r13 Tas2r136 Tas2r140 Tas2r105 Tas2r107 Tas2r4 Tas2r3 Tas2r7 Scnn1a Dhrs3 Scnn1b Scnn1g Rgs9bp Ppef1 Pde6g Rgs9 Grk1 Grk4 Nmt2 Metap1 Metap2 Camkmt Rdh11 Gucy2e Rdh10 Sag Gucy2f Cnga1 Pde6a Pde6b Gnat1 Rcvrn Guca1b Guca1a Opn1mw Awat2 Rho Agrn Tas2r40 Tas2r41 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%10222189 Dimerization of procaspase-8 Ripk1 Tnfsf10 Casp8 Fas Fadd Faslg Traf2 Tradd Cflar ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-RNO-5624958.1 ARL13B-mediated ciliary trafficking of INPP5E Arl13b Pde6d Inpp5e G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition Ywhag Actr1a Ppp2cb Ppp2ca Gtse1 Dctn1 Dctn2 Prkaca Rab8a Akap9 Phlda1 Ofd1 Prkar2b Ppp2r1b Ppp2r1a Ppp1r12b Ppp1r12a Csnk1d Ccp110 Fbxw11 Ppp1cb Nedd1 Mzt2b Tpx2 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Tp53 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Nme7 Hsp90ab1 Cep152 Tuba4a Tubgcp2 Haus4 Haus5 Haus6 Pcnt Ccnh Sfi1 Haus1 Fkbpl Tubgcp6 Tubgcp5 Tubgcp4 Tubgcp3 Cep250 Cep290 Bora Cep78 Cep76 Foxm1 Cep72 Ppme1 Lcmt1 Cep164 Cep70 Mis18bp1 Hjurp Cpap Cdc25b Tubb5 Obi1 Plk4 Odf2 Ticrr Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Cdk7 Fbxl7 Mnat1 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Hsp90aa1 Optn Psma2 Psma1 Rps27a Psmd12 Ppp2r3b Psmd11 Pafah1b1 Psmd14 Cdc25a Psmd13 Ccnb2-ps2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ppp2r2a Dync1h1 Ccnb1 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Dync1i2 Btrc Psma7 Aurka Ajuba Psmc5 Psmc2 Psmc1 Nde1 Psmc4 Psmc3 Wee1 Fzr1 Ubb Ubc Nek2l1 Psmb6l1 Clasp1 Psmd7 Ywhae Psmd6 Pkmyt1 Psmd8 Plk1 Psmd2 Sgo1 Cdc25c Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdk1 Mapre1 Dynll1 Ccnb2 Ckap5 Csnk1e GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Dnm2 Ap2m1 Gja1 Clta Cltb Myo6 Cltc Dab2 Dnm1 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 96%10222161 Pyrimidine salvage Tymp Cda Upp1 Dck Upp2 Pudp Tk2 Uck1 Uck2 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 96%10225523 Degradation of CRY and PER proteins Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Per2 Per1 Per3 Psmb5 Psmb4 Psmb7 REGULATION OF IFNG SIGNALING%REACTOME%R-RNO-877312.1 Regulation of IFNG signaling Ifngr2 Ifngr1 Jak2 Stat1 Pias1 Ptpn2 Socs1 Socs3 Sumo1 Ifng G2 M CHECKPOINTS%REACTOME%R-RNO-69481.1 G2 M Checkpoints Ywhag Gtse1 Blm Wrn Dna2 Pias4 Ube2n Mre11 Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Tp53 Clspn Rad17 Rfc5 Rfc3 Rfc4 Atm Rfc2 Atr Tp53bp1 Exo1 Rmi2 Rmi1 Brip1 Brcc3 ENSRNOG00000066901 Ywhab Herc2 Rnf168 ABRAXAS1 Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Psma4 Ccna1 Psma3 Ccna2 Hist3h2ba Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cdc25a Psmd13 Ccnb2-ps2 Orc4 Orc6 Orc1 Orc3 Orc2 Sfn H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Cdc7 Psmb7 Cdc6 Psmb6 Ccnb1 Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Psma7 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Rpa1 Rpa2 Wee1 Ubb Rpa3 Ubc Psmb6l1 Psmd7 Ywhae Psmd6 Pkmyt1 Psmd8 Psmd2 Cdc25c Psmd1 Adrm1 Cdk2 Cdk1 Ywhaq Ywhah Ccnb2 Ywhaz CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 96%10223009 Chylomicron clearance Ldlrap1 Lipc Apoe Apob Ldlr CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress Suz12 Cox5a Cox5b Eed Gsk3b Hmox1 Rbbp4 Rbbp7 Ube2d3 Ube2d2 Cox4i1 Cox4i2 Mapk3 Mapk9 Mapk7 Mapk8 Cat Fos Rps6ka3 Rps6ka1 Rps6ka2 Map2k7 Map2k6 Lamtor3 Lamtor2 Mapkapk3 Mapk14 Jun Mapkapk2 H1-1 H1-0 Map2k3 H1-5 H1-4 H4f3 Mapk10 Mapk11 Creb3l3 Crebrf Gpx2 Gpx1 Ncoa2 Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Ern1 Atp6v1c1 Terf2 Atp6v0c Acd Terf1 Terf2ip Atp6v1e2 Tinf2 Atp6v1e1 Pot1 Tcirg1 Txnrd1 Atp6v1a Atp6v1b2 Akt3 Atp6v0d2 Akt2 Atp6v0d1 Akt1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Gsr Atp6v1g1 Atp6v1f Ccne1 Atp6v1d Ccne2 Cdkn2b Cdkn2d Hspa8 Rpa1 Rpa2 Rpa3 Cdkn1b Ywhae Rptor RragB Mtor Rheb Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Rragd Mlst8 Map1lc3b Ep400 Asf1a Cabin1 Hira Ubn1 Hmga2 Hmga1 Gstp1 Map3k5 Tnik Mink1 Map4k4 Camk2g Camk2d Camk2b Camk2a Oma1 Mre11 Eloc Kat5 Elob Nbn Ncf1 Ncf2 Ncf4 Hsph1 Dnajc2 Cryab Hikeshi Hspa14 Hspa13 Rps19bp1 Hsbp1 St13 Hspa12b Hspa12a Bag5 Bag3 Bag2 Bag1 Hspb8 Dnajb6 Hspa9 Atm Hspa4 Sirt1 Clec1b Rad50 Ehmt1 Kdm6b Hspa5 Cyba Cybb Cul2 Sod1 Eif2s3 Med1 Eif2s2 Eif2s1 Trim21 Vhl Dync1h1 Xpo1 Dync1i2 Dync1i1 Ajuba Mbtps1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Tgs1 Nup188 Dync1li2 Tpr Nup160 Dync1li1 Rae1 Ndc1 Dynll1 Dynll2 Nup85 Mdm4 Nup42 Nup62 Nup43 Nup88 Ly96 Aaas Ranbp2 Nup214 Tlr4 Nup133 Nup210 Nup155 Nup153 Fabp1 Blvrb Hmox2 Blvra Abcc1 Hsf1 Dnaja1 Hspa1b Sirt3 Hspa1a Alb Arnt Apoa1 P4hb Nploc4 Apob Stip1 Pgrmc2 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Txn Hsp90ab1 Cycsl2 Cycs Sod2 Prkci Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Eef1a1 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp1 Psmb5 Psmb4 Psmb7 Rxra Psmb6 Psmb1 Psmb3 Pgr Psmb2 Uba52 Anapc10 Tbl1x Ube2d1 Anapc16 Btrc Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Hdac3 Fzr1 Ubb Hspa1l Anapc7 Tbl1xr1 Slc46a1 Ubc Foxo3 Ube2e1 Psmb6l1 Psmd7 Rb1 Psmd6 Fkbp4 Hspa2 Psmd8 Fkbp5 Ptges3 Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Carm1 Cul1 Cdk2 Cdc16 Egln1 Egln2 Egln3 Epas1 Mapk1 Hif3a Wtip Mt-co1 Limd1 Ar Hif1a Keap1 Actr1a Ufd1 Dctn1 Dctn2 Dctn4 Higd1c Cited2 Mul1 Sesn2 Sesn1 Cox7a1 Cox7a2 Actr10 Cox7a2l Hba1 Hbb Tp53 H2ab2 H2ac4 Ring1 ENSRNOG00000066901 Phc2 Nr3c2 Cbx6 Nr3c1 Phc1 Cbx4 Cbx2 Esr1 Phc3 Crebbp Ndufa4 Cdk6 H2ac18 Ppara Sin3a Sin3b Bmi1 Prdx2 Prdx5 Hist1h2bq Srxn1 Prdx1 Nfe2l2 H2aj H3-3b Hist3h2ba Sqstm1 Ep300 Rnf2 ENSRNOG00000068602 Smarcd3 Cox6a1 Cox6a2 Txn2 H2bc18 Bach1 H2az2 H2bc4 Hist1h4m H2bc1 Cox6c2 Hist1h2ai Cox6b1 Prdx3 Cox6b2 Atf6 Prdx6 Nprl3 Nprl2 Wdr59 Nox4 Mios Depdc5 Wdr24 Erf Gpx3 Gpx6 Gpx5 Gpx8 Gpx7 Cebpb Fnip1 Fnip2 Samtor Hm13 Hif1an Eif2ak3 Id1 Itfg2 Castor2 Prkaa2 Castor1 Nudt2 Cox8a Ubxn7 Rbx1 Ets1 Cox8c Ets2 Ero1a Szt2 Vcp Atf6b Cox7b Txnrd2 Dnaja2 Cox7c Dnaja4 Kics2 Sod3 Flcn Ccs Sh3bp4 Cdk4 Dnajb1 Cul3 Mapkapk5 Ezh2 NADPH REGENERATION%REACTOME%R-RNO-389542.1 NADPH regeneration Idh1 Aco1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223391 Serotonin and melatonin biosynthesis Tph1 Ddc Asmt Aanat Tph2 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-RNO-6814848.1 Glycerophospholipid catabolism Gde1 Pnpla6 Enpp6 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 96%10223847 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Creb1 Rps6ka1 Rps6ka6 Rps6ka2 Rps6ka3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222487 PKA activation in glucagon signalling Prkar1a Prkar2a Prkar1b Prkar2b Prkaca Prkacb RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-RNO-6807505.1 RNA polymerase II transcribes snRNA genes Ice2 Cdk7 Ell Ccnk Ccnt2 Phax Ell2 Ssu72 Ell3 Srrt Rprd1a Taf9 Rprd1b Taf11 Taf13 Pou2f2 Tbp Gtf2a1 Gtf2a2 Gtf2b Pcf11 Taf8 Taf6 Taf5 Gtf2e1 Polr2c Polr2a Polr2b Gtf2e2 Polr2g Polr2h Polr2e Polr2f Polr2i Polr2j Ncbp2 Ncbp1 Ints4 Ints5 Supt4h1 Ints6 Gtf2f2 Gtf2f1 Ints7 Ints8 Snapc3 Ints9 Snapc4 Ints13 Snapc1 Ints14 Ints1 Snapc2 Ints2 Ints11 Ints3 Ints12 Ints10 Zc3h8 Rprd2 Cdk9 Nabp1 Pou2f1 Nabp2 Rpap2 Sp1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 96%10222463 Signaling by GPCR Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Prkcq Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 Creb1 Hbegf Mapk3 Nras Grb2 Kras Sos1 Hras App Mapk7 Rps6ka3 Rps6ka1 Rps6ka2 Egfr Rasgrf2 Gna12 Itgb1 Pde3b Akt3 Akt2 Akt1 Prkch Prkce Grk3 Mgll Pik3r6 Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Itpr3 Itpr2 Itpr1 Pak1 Pde10a Daglb Src Rhoa Ngef Trpc7 Trpc3 Dagla Pde11a Arrb2 Arrb1 Lhb Cga Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Rhob Agt Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Qrfprl Qrfpr Qrfp Hcrt Pde2a Pik3ca Shc1 Pik3r1 Pik3r2 Pik3r3 Pik3r5 Pik3cg Pdpk1 Ednrb Ednra Plxnb1 Sct Rrh Ptgdr Htr4 Apln Trhr Tas2r39 Htr6 Oprd1 Htr7 Tas2r38 C3ar1 Crhbp Galr2 Galr3 Galr1 Cmklr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Ppbp Fpr1 Btk Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Vipr2 Nln Vipr1 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Rhoc Ppy Tas2r135 Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Rock2 Arhgef7 Brs3 Ptger4 Rock1 Tas2r7 Gabbr1 Ptger2 Ptger3 Fshr Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Crhr1 Ccr3 Gpr132 Edn1 Gast Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr1 Agtr2 F2 Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ghrh Ptgdr2 Rho Mmp3 Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ptgdrl Ccl27 Npsr1 Plcb4 Prok1 Plcb3 Ramp3 P2ry10 Mapk1 Pla2g4a Ramp2 Pdyn Mc3r Plcb2 P2ry13 Plcb1 P2ry12 Ccl20 Ppp1r1b Gpr55 Gng10-ps1 Adcy3 Ccl21 Adcy4 P2ry14 Adcy1 Adm2 Adcy2 Mcf2 F2rl1 Tas2r40 Camkk1 Adcy7 Fpr2l1 Tas2r41 Camkk2 Adcy8 Cd55 Ppp1ca F2rl2 Adcy5 F2rl3 Adcy6 Hcar1 Ppp2cb Prokr2 Ppp2ca Adra2b Adcy9 Hcar2 Prokr1 Pde4a Cxcr1 Pde4b Cxcr2 Prkaca Cxcr3 Prkacb Prkcg Npy1r Prkcd Xk Gpr65 Oprm1 Gpr68 Gnai2 Gnai1 Cxcr4 Prkca Cxcr5 Iapp Gnai3 Oprl1 Gna11 Camk4 Adrb2 Prkar1a Adrb1 Adra1b Gna14 Prkar1b Adrb3 Calm3 Adra1a Ppp2r5d Adra1d Lhcgr Gng3 Uts2 Grk2 Mc5r Gnal Prlh Pomc Tacr1 Gng5 Tacr3 Gng4 Tacr2 Pde4c Anxa1 Gnaq Cxcl11 Gng7 Hebp1 Pde4d Calcr Gng8 Gngt1 Cxcl12 Casr Gnat3 Prkar2a Cxcl10 Prkar2b C5ar2 F2r Ppp2r1b Ppp2r1a C5ar1 Ffar3 Cdk5 Pde1b Aplnr Bdkrb2 Pde1c Ffar1 Gnb2 Bdkrb1 Gnb1 Ffar2 Pde1a Nts Gnb4 Kng1 Gnb3 Calcb Gnb5 Chrm1 Gng11 Calca Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Adra2a Opn5 Adora2b Sucnr1 Pyy Adora2a Adora1 Adra2c Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh P2ry2 Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Ffar4 Grm8 Htr2a Ghrl Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Insl3 Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Ackr4 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Rgs9 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Gnat1 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Rgs20 Rgs17 Rgs16 Gnaz Cdc42 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10224939 COPI-mediated anterograde transport Actr1a Ins2 Dctn1 Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Tmem115 Kdelr2 Kdelr3 Spta1 Copa Bet1l Gorasp1 Sptb Sptbn1 Sptbn2 Kdelr1 Arf4 Arf3 Sptan1 Arf1 Sptbn5 Sptbn4 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Rab1b Gosr1 Gosr2 Dync1h1 Copz2 Copz1 Arf5 Golga2 Uso1 Actr10 Dync1i2 Dync1i1 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Cd59 Arcn1 Bet1 Dync1li2 Dync1li1 Dynll1 Dynll2 Ins1 Cd55 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%10222611 Regulation of clotting cascade F10 Procr F12 Gpc1 F11 Gpc3 Gpc2 Gpc5 Gpc4 Thbd Smpd1 Gpc6 Proc Klkb1 Pros1 Serpinc1 Sdc1 Serpine2 Serping1 Tfpi Proz Serpina10 Cd177 Pf4 Agrn Gp5 F2r Gp9 Gp1bb Serpine1 Gp1ba Ano6 Ano5 Kng1 F3 F7 F9 App Serpina5 Sdc4 Sdc3 Sdc2 F2 F8 Prtn3 Serpind1 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-RNO-9027284.1 Erythropoietin activates RAS Grb2 Irs2 Jak2 Vav1 Epor Shc1 Lyn Crkl Rapgef1 Epo DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%10224851 DNA Damage Recognition in GG-NER Ino80 Xpc Ddb2 Uba52 Cops4 Ino80e Cops2 Ino80d Ino80c Ino80b Cops7a Cops7b Mcrs1 Actg1 Ubb Ubc Ruvbl1 Parp2 Rad23a Parp1 Rad23b Nfrkb Rbx1 Cops3 Cops6 Tfpt Cops8 Actl6a Gps1 Rps27a Actr5 Yy1 Actr8 Cops5 Ddb1 Cul4a Cetn2 Cul4b FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 96%10222417 Formation of Incision Complex in GG-NER Chd1l Sumo3 Xpc Ddb2 Ube2n Gtf2h2 Ube2i Gtf2h1 Uba52 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Ercc1 Ercc4 Usp45 Ube2v2 Mnat1 Rpa1 Rpa2 Ubb Rpa3 Ubc Rnf111 Parp2 Rad23a Parp1 Rad23b Sumo2 Rbx1 Ccnh Rps27a Pias3 Pias1 Xpa Ddb1 Sumo1 Cul4a Cetn2 Cul4b MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222847 MAP kinase activation Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Uba52 Nfkb1 Fbxw11 Fos Btrc Vrk3 Rps6ka3 Rps6ka1 Rps6ka2 Tnip2 Nod2 Nod1 Map2k7 Map2k6 Ubb Dusp3 Ubc Dusp4 Ripk2 Dusp7 Dusp6 Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Cul1 Map2k3 Mapk1 Tab3 Tab2 Tab1 Chuk Mapk10 Mapk11 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%10224567 Regulation of necroptotic cell death Peli1 Uba52 Traf2 Birc2 Xiap Ubb Sdcbp Ogt Ubc Casp8 Mlkl Flot2 Flot1 Ripk3 Tradd Cflar Prkn Hsp90aa1 Stub1 Itch Ripk1 Rps27a Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Ube2l3 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding Klb Fgf19 Fgfr4 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism Adcy5 Kcnb1 Adcy6 Kcns3 Kcnc2 Kcng2 Prkaca Prkacb Gnai2 Gnai1 Prkca Prkab2 Cacna1c Gna11 Cacna1d Adipoq Prkar1a Gna14 Adipor2 Prkar1b Adipor1 Mlxipl Marcks Gng3 Gng5 Gng4 Gnaq Gng7 Cacnb3 Gng8 Cacna1e Gngt1 Cacnb2 Itpr3 Cacna1a Prkar2a Itpr2 Slc2a2 Prkar2b Itpr1 Cacna2d2 Ffar1 Gnb2 Abcc8 Gnb1 Kcnj11 Gnb4 Gnb3 Gnb5 Gng11 Rap1a Gnas Acsl3 Acsl4 Cd36 Adra2a Adra2c Gcgr Rapgef4 Rapgef3 Prkaa2 Slc2a1 Gcg Plcb3 Glp1r Plcb2 Taldo1 Plcb1 Prkag2 Gng10-ps1 Tkt SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 96%10224521 SUMOylation of transcription cofactors Phc1 Sumo3 Cbx4 Zfp131 Pias4 Cbx2 Ube2i Phc3 Daxx Safb Ing2 Sin3a Trim28 Pcgf2 Bmi1 Mbd1 Park7 Mrtfa Npm1 Sumo2 Ep300 Nrip1 Rnf2 Ctbp1 Pias3 Ddx17 Pias1 Ring1 Pias2 Casp8ap2 Phc2 Uhrf2 Sumo1 ACTIVATION OF TRKA RECEPTORS%REACTOME%R-RNO-187015.1 Activation of TRKA receptors Ntrk1 Ngf SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224313 Synthesis of PIPs at the Golgi membrane Fig4 Vac14 Pi4k2a Pik3r4 Inpp5e Arf3 Arf1 Ocrl Sacm1l Pi4ka Pi4kb Pi4k2b Pik3c2g Tpte2 Pikfyve Pik3c2a Pik3c3 CD28 CO-STIMULATION%REACTOME%R-RNO-389356.1 CD28 co-stimulation Ppp2r5b Pik3r5 Ppp2r5a Pik3cg Map3k8 Ppp2cb Ppp2ca Pdpk1 Cd28 Ppp2r5e Rictor Cd86 Cd80 Prr5 Map3k14 Trib3 Ppp2r5d Lck Mapkap1 Grap2 Them4 Pik3ca Pak1 Rac1 Pak3 Ppp2r1b Ppp2r1a Mtor Pak2 Akt3 Akt2 Lyn Akt1 Yes1 Src Pik3r1 Pik3cb Grb2 Pik3r2 Fyn Pik3r3 Vav1 Pik3cd Pik3r6 Cdc42 Ctla4 Mlst8 CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport Slc5a10 Slc2a2 Slc2a4 Slc2a1 Slc2a8 Slc2a3 Slc2a7 Slc2a9 Slc2a12 Slc50a1 Slc2a10 Slc45a3 Fgf21 Slc5a1 Slc5a2 Slc5a4 Mfsd4b4 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 96%10224065 Reactions specific to the complex N-glycan synthesis pathway Chst10 Fut8 Fuca1 Man2a1 Man2a2 Mgat2 PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis Prps1l3 Prps1 Prps2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223763 Bicarbonate transporters Slc4a1 Slc4a10 Ahcyl2 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc4a7 Slc4a9 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224171 ATP sensitive Potassium channels Abcc9 Kcnj8 Abcc8 Kcnj11 COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Ndufa5 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Nubpl Acad9 Ndufv2 Ndufv1 Ndufv3 Ndufc2 Ndufa12 Ndufa11 Ndufa10 Ndufs1 Ecsit Ndufab1 Timmdc1 Ndufa13 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa6 Hscb Ndufa9 Ndufb8 Ndufs3 Ndufa8 Ndufb11 Ndufb10 Ndufb1 Ndufb3 Rnf113a1 Ndufb5 Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Hspa9 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism Tkfc Aldh1a1 Glyctk Aldob Khk ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-RNO-399997.1 Acetylcholine regulates insulin secretion Plcb3 Gna11 Gna14 Plcb2 Plcb1 Marcks Gnaq Prkca SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 96%10222853 Signaling by Interleukins Creb1 Stx1a Mapk3 Crkl Rapgef1 Rps6ka5 Grb2 Fyn P4hb Sos1 Tyk2 Il1rl2 Nkiras1 Il1f10 Vamp2 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Il6st Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Brwd1 Tslp Gsdmd Nfkb1 Il7 Traf2 Il7r Fbxw11 Il36a Fos Vrk3 Il36rn Il36g Alpk1 Rela Il18rap Il18r1 Rps6ka3 Il18bp Peli2 Rps6ka1 Sdc1 Peli3 Tifa Irs1 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Tec Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Mapkapk2 Irak2 Il6 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Il6r Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Il1rapl1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Vamp7 Psmb1 Psmb3 Psmb2 Uba52 Cntf Btrc Cntfr Psma7 Ifnlr1 Clcf1 Ctf1 Il20rb Psmc5 Il20ra Psmc2 Il31ra Psmc1 Lif Psmc4 Il10 Psmc3 Il11 Il22ra2 Stxbp2 Osmr Il10rb Il10ra Il22 Il11ra1 Ubb Il20 Il24 Ubc Osm Il22ra1 Psmb6l1 Lifr Ifnl1 Psmd7 Casp1 Ifnl3 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Mapk1 Il12rb1 Crk Il12rb2 Ebi3 Stx4 Il12b Il27 Il23a Il12a Crlf1 Ppp2cb Il23r Ppp2ca Prkaca Il33 Ppp2r5d Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Ppp2r1b Il1b Ppp2r1a Il1r2 Il1r1 Lyn Yes1 Il34 Ptprz1 Il16 Txlna Csf1r Stx3 Il18 Cd4 Lck Jak2 Snap25 Ctsg Socs1 Il13ra2 Il4r Stat6 Il13 Hsp90b1 Socs5 Il4 Stat3 Stat1 Il15 Il15ra Il9 Il21 Ptk2b Stat5a Stat5b Il9r Inpp5d Canx Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Smarca4 Il2 Il3 Il5 Csf2rb Sqstm1 Csf1 Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Vav1 Inppl1 Pik3cd Ptpn11 H2bc18 Sos2 Irs2 Syk Hck Il1rl1 Casp3 Myd88 Rbx1 Socs3 Cbl Ywhaz GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport Actr1a Dctn1 Dctn2 Rab1A Dctn4 Arfgap3 Arfgap2 Rab18 Arfgap1 Napa Nsf Napb Galnt1 Galnt2 Napg Kif3a Kdelr2 Kdelr3 Copa Kdelr1 Arf4 Arf3 Arf1 Copb2 Tmed10 Tmed9 Copb1 Cope Copz2 Copz1 Arf5 Actr10 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Arcn1 Kif4b Kif4a Racgap1 Bnip1 Kif18b Kif19 Kif26b Kifc1 Kifc2 Kif26a Kif11 Kif12 Kif15 Nbas Kif5a Kif5b Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Kif6 Kif9 Pafah1b1 Zw10 Rab3gap2 Rab3gap1 Kif22 Rab1b Kif23 Kif28 Rint1 Kif27 Kif16b Bicd2 Kif18a Kif20a Bicd1 Klc1 Agpat3 Dync1h1 Kif20b Pafah1b3 Kifap3 Pafah1b2 Klc4 Klc3 Klc2 Dync1i2 Dync1i1 Kif3b Kif3c Stx18 Pla2g6 Cenpe Kif2a Kif2b Use1 Kif2c Dync1li2 Dync1li1 Dynll1 Pla2g4a Dynll2 Rab6b Rab6a UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases Keap1 Wdr48 Ddb2 Ufd1 Foxo4 Ifih1 Fkbp8 Il33 Wdr20 Adrb2 Atxn7 Suds3 Tnks2 Usp2 Mul1 Rce1 Usp3 ENSRNOG00000067432 Usp4 Axin1 Axin2 Usp5 Usp7 Usp8 Hgs Ruvbl1 Tomm20 Tada2b Smad1 Smad2 Smad3 Smad4 Smad7 Ide Otub1 Usp44 Usp42 Usp48 Ripk1 Rnf146 Usp47 Stam2 Usp30 Tnks Usp33 Usp37 H2ac25 Usp34 Usp9x Usp22 Usp21 Smurf2 Usp20 Traf6 Usp26 Usp25 Ikbkg Usp24 Usp29 Map3k7 Usp28 Ccp110 Arrb2 Arrb1 Pten Traf2 Usp12 Tgfbr1 Usp11 Usp10 Usp16 Usp15 Usp13 Usp19 Tp53 Clspn Kat2a Polb Rig1 Nfkbia H2ac4 Cyld Usp14 Gata3 Usp18 Tab1 Birc2 H2ac18 Taf9b Taf10 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cdc25a Psmd13 Skp2 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Tada3 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Myc Psmd2 Psmd1 Vdac2 Adrm1 Vdac3 Vdac1 Becn1 Tomm70 Mdm4 Rnf123 Rnf128 Snx3 Ar Hif1a Cftr Siah2 Mat2b HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224645 Hedgehog ligand biogenesis Os9 Sel1l Disp2 Scube2 Hhat Psma4 Psma3 Notum Syvn1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 P4hb Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Gpc5 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Ihh Psmd2 Derl2 Psmd1 Shh Adrm1 Vcp Dhh Erlec1 DEPYRIMIDINATION%REACTOME%R-RNO-73928.1 Depyrimidination Neil1 Mbd4 Smug1 Ogg1 Nthl1 Tdg Ung Neil2 GENE SILENCING BY RNA%REACTOME%R-RNO-211000.1 Gene Silencing by RNA Polr2j Hist1h2ai Prkra H2ac18 Ago4 Ago3 Ago2 Ago1 Dicer1 Tarbp2 Hist1h2bq Ipo8 H2aj Tsnax H2ab2 Tnrc6c H3-3b Hist3h2ba Tnrc6a H2ac4 Tnrc6b ENSRNOG00000068602 Polr2c Polr2a Polr2b H2bc18 Polr2g Polr2h Tsn ENSRNOG00000066901 H2az2 Polr2e Ran Polr2f H2bc4 Hist1h4m Polr2i H2bc1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine Neil1 Mbd4 Smug1 Ogg1 Nthl1 Tdg Ung Neil2 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 96%10224479 Ca2+ pathway Lef1 Map3k7 Ctnnb1 Pde6a Pde6b Wnt5a Gnat2 Calm3 Gng3 Ppp3ca Ppp3cb Nfatc1 Gng5 Gng4 Ppp3r1 Wnt11 Gng7 Gnao1 Nlk Gng8 Gngt1 Fzd3 Tcf7l2 Fzd2 Fzd5 Fzd4 Fzd6 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Kras Gng10-ps1 Pde6g Camk2a MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis Nfs1 Gphn Mocos Mocs3 Mocs1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222039 Aerobic respiration and respiratory electron transport Pdp1 Cox5a Pdpr Cox5b Pdp2 Pkml1 Ranbp9 Sirt3 Cox4i1 Cox4i2 Suclg1 Suclg2 Isca2 Pm20d1 Isca1 Trap1 Sdhaf1 Sdhaf2 Sdhaf3 Cs Slc25a27 Nnt Slc25a14 Ucp1 Ucp2 Ucp3 Fh Sdhd Sdhc Sdhb Sdha Aco2 Idh3B Idh3g Sucla2 Idh3a Fxn Ecsit Hscb Ndufb8 Ndufs3 Ldhal6b Glo1 Wdr26 Hagh Nek1 Mkln1 Fahd1 Gid4 Maea Ldha Ldhb Ldhc Armc8 Me1 Me3 Me2 Rmnd5b Cycsl2 Cox18 Tmem177 Cox20 Idh2 Cycs Mt-cyb Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Pdhx Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Ndufa5 Pdk4 Rps27a Pdk3 Pdk2 Pdk1 Pdhb Uba52 Ndufab1 Pdha1 Pdha2 Ubb Ubc Mt-co3 Dld Mt-co2 Vdac1 Mt-co1 Dlat Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 Gstz1 Nfs1 Higd1c Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Uqcrfs1 Nubpl Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Cyc1 Slc25a18 Ndufv2 Cox7a1 Slc25a22 Ndufv1 Cox7a2 Ndufv3 Uqcrb LOC120097699 Uqcrh Ndufc2 Ndufa12 Slc25a4 Ndufa11 Ndufa10 Ndufs1 Timmdc1 Ndufa13 Cox7a2l Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Ndufb1 Lyrm7 Ndufb3 Rnf113a1 Hccs AC132020.1 Uqcrc2 Ogdh Uqcrc1 Dlst Etfb Lyrm4 Kgd4 Ndufb5 Etfa Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Uqcr10 Ttc19 Hspa9 Pgam5 Ndufa4 Got2 Cox6a1 Cox6a2 Cox6c2 Cox6b1 Cox6b2 Gpt Adhfe1 L2hgdh D2hgdh Got1 Mdh1 Cox8a Mdh2 Slc25a11 Cox8c Slc25a12 Slc25a13 Cox7b Pc Cox7c Acat1 Pklr CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling Gsk3b Crmp1 Plxna4 Plxna3 Plxna2 Cdk5 Dpysl3 Dpysl2 Dpysl4 Dpysl5 Sema3a Fes Fyn Nrp1 Plxna1 Cdk5r1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-RNO-2871796.1 FCERI mediated MAPK activation ENSRNOG00000070986 Plcg1 Shc1 Rac1 Pak1 Pak2 Mapk3 Lyn Nras Vav3 Grb2 Vav1 Kras Vav2 Sos1 Hras Mapk9 ENSRNOG00000069193 AABR07065813.1 Lcp2 ENSRNOG00000062915 Igll1 Mapk8 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Syk Iglc1 Fos ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Map3k1 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Map2k7 Plcg2 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 Grap2 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 Jun ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 Lat Mapk10 NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation Slco4c1 Ddost Magt1 Ppie Cfp Acaa1b Fuca1 Slc27a2 Sptan1 Nras Sting1 Rap1a Rap1b Tnfrsf1b Slc15a4 Iqgap2 Mmtag2 Nbeal2 Prdx4 Plac8 Cat Pgrmc1 Commd9 Golga7 Retn Lgals3 Ptprn2 Bin2 Nfkb1 Pa2g4 Cd36 S100a11 S100a9 Dynlt1 Gmfg Syngr1 Vapa Clec4a3 Clec4a2 Glipr1 Man2b1 Tmc6 Clec4b2 Grn Ceacam6 Ptges2 Enpp4 Cgm4 Ypel5 Nfam1 Clec6a-ps1 Aga Commd3 Pigr Pygb Kpnb1 Hmgb1-ps34 Crispld2 Ormdl3 Lamtor3 Dnajc13 Lamtor2 Lilrc2 Armc8 Rab44 Adgrg3 Vcl Ear1l1 Chrnb4 Epx Kcmf1 Mapk14 Tom1 Serpinb1a Rab37 Serpinb12 Ist1 Serpinb10 Psgb1 Hmgb1l2 Pkp1 Hmgb1l1 Dsc1 Bri3 Gpr84 Ptprb Ghdc Lamp1 Cep290 Arl8a Rab3d Ap2a2 Nit2 Chi3l1 Mospd2 Acp3 Tubb5 Slc2a5 Alad Itgav Crisp2 Olfm4 Atad3a Fgl2 Chit1 Dnase1l1 Hgsnat Mnda Frmpd3 Tubb4b Rnase17 Agpat2 Fcgr3a Mcemp1 Scamp1 Tmem179b Cant1 Unc13d Cpne1 Cpne3 Tmem30a Rnase2 Rnase3 Vat1 Tspan14 Cdk13 Prg3 Anpep Prg2 Fcn2 Bst2 Fcn1 Rap2b Rap2c Manba Cr1l Cap1 Mlec Snap29 Atp6v0a1 Cd53 Stk11ip Svip Atp6v0c ENSRNOG00000064486 Qpct ENSRNOG00000064129 Irag2 Cstb Gca Erp44 Elane Creg1 Hp Tcirg1 Cd68 Dok3 Hebp2 Cd93 ENSRNOG00000067708 Cotl1 Dpp7 Tarm1 Degs1 Ggh Cnn2 Atp6v1d Rab31 Nme2 Psg29 Dnajc5 Ddx3x Cracr2a Clec4a Clec4d Cpped1 Mvp Ms4a3 Pdap1 Kcnab2 Fth1-ps5 Oscar Tmem63a Cmtm6 Tnfaip6 Vps35l Ostf1 Ap1m1 Ptx3 Vamp8 Pafah1b2 Fth1 Slc44a2 Txndc5 Hspa8 Rab3a Ftl1 Itgax Gdi2 Rab7a Cfd A1bg Rab27a Cab39 Olr1 Tbc1d10c Lamtor1 Trappc1 Rab6a Ceacam1 Rab5c Ahsg Rab5b Serpina3n Serpinb6a Rab9b Rab10 Igf2r Rab14 Rab18 RT1-M6-2 Mgst1 Anxa2 Qsox1 B2m Gsn Gstp1 Atg7 Sh3glb2 Lamp2 RT1-M10-ps1 Pnp RT1-M10-ps5 Snap23 Cd177 Ampd3 RT1-N3 Aprt Rhoa Lrrc7 Itgal Eef2 Apeh Itgb2 RT1-M1-2 RT1-M1-5 Rt1-ec3 Arsa Mpo Huwe1 Asah1 P2rx1 Gm2a Mif Gla Arsb Xrcc6 Orm1 Rhog Xrcc5 Ano6 RT1-M5 Rab4b Atp6ap2 Ctsd Cd47 Ubr4 Mme RT1-M2 Ctsg Cd63 Cand1 Ctsz Prtn3 Ppia Padi2 Fcer1g Sell Cyba Cybb Sirpa Plau Pecam1 Npc2 Ptpn6 Plaur Fuca2 Trpm2 Dync1h1 Alox5 Lta4h AABR07044308.1 Lpcat1 Cst3 Atp11b Atp11a Gpi Arg1 Atp8b4 Dync1li1 Aoc1 Dynll1 Pgam1 Ticam2 Cd14 Aldoc Aldoa Pfkl Hmox2 Pkml1 Hk3 Hpse Hspa1b Hspa1a Nckap1l Ptprc Ttr Gsdmd S100a8 Tlr2 Ctsb Arhgap45 Ctss Arpc5 Dgat1 Jup Dsp Dsg1 Stom C3ar1 Impdh2 Pycard Arhgap9 Impdh1 Pld1 Hsp90ab1 Stk10 Faf2 Actr2 Mmp25 Ppbp Fpr1 Diaph1 Gns Adam10 Fpr2 C3 Galns Hexb Cyfip1 Krt1 Prcp Rhof Stbd1 Dock2 Adam8 Mmp8 Try10 Prss2l1 Tyrobp Try5 Cd44 LOC102554637 Sdcbp Rock1 Capn1 Timp2 Prss2 Acly Prss3 Rac1 Prss1 Psma5 Psma2 Hsp90aa1 Psmd12 Eef1a1 Psmd11 Psmd14 Psmd13 Psmb7 Dnajc3 Pdxk Psmb1 Ilf2 Psmc2 Srp14 Bst1 Psmc3 Vnn1 Ptafr Naprt Psmd7 Psmd6 Mmp9 Psmd2 Psmd1 Slc2a3 Mapk1 Fabp5 Cyb5r3 Dera Pgm2 Cd55 Clec5a Cxcr1 Apaf1 Cxcr2 Folr2 Prkcd Gusb Cda Tollip C5ar1 Nfasc Ctsc Np4 Defa24 Ear1 Copb1 Defal1 Pglyrp1 Defa31 Bpi Defa Camp Serpina1 Ltf Lyz1 Ndufc2 Actr10 Ctsh Hbb Slc11a1 Aldh3b1 Defa9 Defa8 Defa6 Cd59 Defa3 Lcn2 Ckap4 Idh1 Snap25 Psap Actr1b Siglec5 Siglec8 Adgre5 Cct2 Cxcl1 Lair1 Cct8 Csnk2b Gaa Agl Pygl Gyg1 Pgm1 Psen1 Ncstn Neu1 Fcgr2 Fgr Frk Prdx6 Glb1 Ctsa Vcp Hvcn1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-RNO-5685939.1 HDR through MMEJ (alt-NHEJ) Fen1 Parp2 Mre11 Parp1 Rbbp8 Brca2 Rad50 Rad52 Nbn Polq Xrcc1 Lig3 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%10223573 Tachykinin receptors bind tachykinins Tacr1 Tacr3 Tac3 Tacr2 Tac1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 96%10222361 Transport of Mature mRNAs Derived from Intronless Transcripts Nup133 Cpsf1 Nup210 Ncbp2 Cpsf2 Nup155 Ncbp1 Cpsf3 Nup153 Nup93 Nup50 Alyref Nxf1 Slbp Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Fip1l1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Sympk Aaas Eif4e Ranbp2 Cpsf4 Nup214 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 96%10223599 Adipogenesis Pparg Ncor2 Hdac3 Rxra PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-RNO-77595.1 Processing of Intronless Pre-mRNAs Cpsf7 Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Pcf11 Fip1l1 Cstf1 Papola Nudt21 Cstf2 Cstf3 Cstf2t Sympk Pabpn1 Clp1 Cpsf4 Cpsf6 VITAMINS%REACTOME DATABASE ID RELEASE 96%10223395 Vitamins Cyp26b1 Cyp26a1 Cyp24a1 Cyp26c1 Cyp27b1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-RNO-192105.1 Synthesis of bile acids and bile salts Osbpl6 Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Amacr Baat Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Akr1c19 Nr1h4 Akr1c21 Cyp46a1 Scp2 Cyp27a1 Osbp Slc27a5 Cyp7a1 Acox2 Abcb11 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Hsd17b4 Akr1c9 Slc27a2 Ch25h Osbpl3 Osbpl2 Acot8 Osbpl1a Osbpl7 Rxra MELANIN BIOSYNTHESIS%REACTOME%R-RNO-5662702.1 Melanin biosynthesis Slc45a2 Dct Tyr Oca2 Tyrp1 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225141 Interleukin-9 signaling Jak3 Stat3 Stat1 Il9 Stat5a Stat5b Il9r BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs Alox12 Ptgs2 Alox5 Alox15 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere Terf2 Acd Terf1 Rfc5 Terf2ip Pold2 Tinf2 Pold1 Rfc3 Pot1 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Chtf8 Chtf18 Ctc1 Stn1 Ten1 Dscc1 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225347 RND3 GTPase cycle Wdr6 Txnl1 Epha2 Dlg5 Ccdc88a Ubxn11 Arhgap35 Cpd Ankrd26 Picalm Dst Tmod3 Dsp Arhgap5 Ktn1 Plekhg5 Dsg1 Nisch Ckap4 Ckb Rock1 Scrib Ddx4 Fam83b Rnd3 Cav1 Flot2 Kctd13 Pik3r1 Pik3r2 Sema4f Rbmx Depdc1b Ptpn13 Vangl2 Muc13 Arhgap21 Tnfaip1 Rasal2 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%10223923 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Xrn1 Zfp36l1 Mapkapk2 Dis3 Akt1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Exosc3 Exosc2 Ywhab Dcp1a REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%10222543 Regulated Necrosis Birc2 Bax Bak1 Gzmb Xiap Sdcbp Elane Il1a Il1b Mlkl Flot2 Flot1 Ripk3 Tradd Cflar Prkn Hsp90aa1 Stub1 Itch Ripk1 Rps27a Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Ube2l3 Chmp2a Peli1 Uba52 Gsdme Gsdmd Traf2 Il18 Casp3 Ubb Ogt Hmgb1-ps34 Ubc Casp1 Casp8 Chmp2b Cycsl2 Chmp3 Hmgb1l2 Chmp7 Hmgb1l1 Chmp6 Chmp4c Chmp4bl1 Cycs PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-RNO-169893.1 Prolonged ERK activation events Braf Frs2 Ntrk1 Ngf Mapk3 Crkl Rapgef1 Map2k2 Map2k1 Mapk1 Rap1a Ywhab Crk Kidins220 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006927.1 Signaling by Non-Receptor Tyrosine Kinases Erbb2 Ccnd1 Erbb3 Ereg Uba52 Stat3 Stap2 Nrg2 Gpnmb Lrrk2 Nrg3 Dok1 Btc Arhgap35 Rasa1 Egf Elmo1 Ubb Elmo2 Arap1 Ubc Pxn Cdkn1b Egfr Bcar1 Ptpn1 Rac1 Sfpq Khdrbs1 Khdrbs3 Hbegf Khdrbs2 Akt1 Cdk2 Socs3 Rhoa Cbl Nras Ccne1 Rps27a Kras Hras Cdk4 Srms Hif1a Crk Ptk6 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855196.1 IP3 and IP4 transport between cytosol and nucleus Nup133 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 96%10223265 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Siglec10 Klrk1 Jaml RT1-M6-2 B2m Itga4 RT1-M10-ps1 RT1-M10-ps5 RT1-N3 Itgal Itgb2 Cd40lg RT1-M1-2 Cd40 Cd22 RT1-M1-5 Rt1-ec3 Cd3g Cd247 Cd3e Cd3d Trav19 Trem1 AC109737.1 ENSRNOG00000065955 Trbv16 Nectin2 Pvr RT1-M5 Siglec1 Siglec5 Siglec8 LOC100910497 RT1-M2 Slamf6 Slamf7 Hcst C3 Kir3dl1 Pilrb2l4 Ifitm1 Ifitm2 Ifitm6 Pilrb1l3 Pilrb-ps7 Cd160 ENSRNOG00000070312 Pianp Cd226 Ifitm3-ps2 LOC134481331 Lair1 Treml2 Treml4 Cd200 Sell Cd1d ifitm3 Trem2 Cd34 Itgb1 Cd200r1l LOC120093164 Cd96 Cd81 Crtam Cd8b Cd8a Cd300le Cd300ld Cd300lg Cd300lf Klrb1a Clec4g Clec2e Cd19 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 AABR07044308.1 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Cxadr Igkvl13 AABR07065812.2 ENSRNOG00000063707 Madcam1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 Itgb7 ENSRNOG00000064481 Icam1 ENSRNOG00000065690 Icam5 ENSRNOG00000064085 Icam4 ENSRNOG00000066904 Icam2 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 Vcam1 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224415 NOTCH3 Activation and Transmission of Signal to the Nucleus Aph1b Ybx1 Egfr Jag1 Uba52 Jag2 Notch3 Dll1 Dll4 Rps27a Egf Adam10 Wwp2 Psenen Psen1 Psen2 Ubb Ncstn Ubc Aph1a FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-RNO-9615017.1 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Atxn3 Foxo4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 96%10223845 Zinc influx into cells by the SLC39 gene family Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc39a8 Slc39a7 Slc39a6 Slc39a14 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism Dsel Ust Dse Cspg5 Bgn Cspg4 Chst14 Chst15 Idua Hyal4 Hyal3 Naglu Ids Hyal1 Hpse2 Hpse Gusb Sgsh Slc9a1 Abcc5 Sdc4 Sdc3 Sdc2 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Slc26a2 Slc26a1 Gpc6 Slc35b3 Slc35b2 Papss2 Papss1 Slc26a11 Sdc1 Arsb Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Gns B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Glb1l2 Fmod Galns Uxs1 Hexa Hexb B4gat1 Lum Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Hyal5 Ogn Ctsl Cd44 Chp1 Slc17a5 B3galt6 Cemip Fam20b St3gal6 B4galt7 Pxylp1 St3gal4 Chp1l1 Hyal2 St3gal2 Has1 St3gal3 Has2 Has3 St3gal1 Xylt1 Hs3st4 Xylt2 Hs3st1 Glb1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Bcan Hs2st1 Ndst1 Vcan Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Ncan Hs6st2 Dcn Hs6st1 Ext2 Ext1 Chst11 Chst12 Chsy1 Chsy3 Chst13 Chpf Csgalnact2 Chst7 Chst9 B3gnt3 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Xab2 Cdk7 Ppie Ercc1 Ercc4 Tcea1 Mnat1 Polk Prpf19 Usp7 Cops3 Cops6 Cops8 Isy1 Rps27a Gps1 Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ercc6 Polr2i Polr2j Gtf2h2 Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Cops4 Ercc2 Ercc3 Cops2 Lig3 Pole3 Pole2 Cops7a Pole4 Cops7b Znf830 Rpa1 Rpa2 Aqr Uvssa Ubb Rpa3 Ubc Lig1 Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Xrcc1 Rfc2 Ccnh Pold4 Pold3 Cops5 Xpa Ddb1 Cul4a Cul4b TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%10223367 Transport to the Golgi and subsequent modification Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Fut8 Tmem115 Fuca1 Kdelr2 Man2a1 Kdelr3 Man2a2 Mgat2 Sec23ip Sec16b Sec16a Spta1 Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Sptb Cnih2 Sptbn1 Sptbn2 Kdelr1 Arf4 Ctsc Arf3 Sptan1 Sptbn5 Arf1 Ppp6r3 Mia2 Sptbn4 Mia3 Sar1b Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Tgfa Ppp6c Sec31b Gria1 Areg Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 B4galt4 B4galt5 B4galt6 Ctsz B4galt2 B4galt3 Chst10 Rab1b Trappc2l Dync1h1 St8sia6 Trappc10 Dync1i2 Dync1i1 St3gal4 St6gal1 Mgat5 Mgat1 Mgat3 Mgat4a St8sia2 Manea St8sia3 Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Sec13 Trappc6b Dync1li2 Trappc6a Trappc9 Dync1li1 Trappc5 Dynll1 Trappc4 Dynll2 Trappc3 Trappc2 Trappc1 Ins1 Cd55 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%10223821 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp9 Aqp7 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%10222573 GPVI-mediated activation cascade Pik3r5 Pik3cg Pdpk1 Fcer1g Mpig6b Pdpn Syk Lck Plcg2 Pik3ca Gp6 Rhog Rac1 Ptpn6 Rhob Rac2 Lyn Pik3r1 Rhoa Pik3cb Vav3 Pik3r2 Fyn Pik3r3 Vav1 Vav2 Ptpn11 Pik3r6 Lat Cdc42 Lcp2 Clec1b REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%R-RNO-1234158.1 Regulation of gene expression by Hypoxia-inducible Factor Cited2 Epas1 Hif3a Crebbp Hif1a Ep300 Arnt CIPROFLOXACIN ADME%REACTOME%R-RNO-9793528.1 Ciprofloxacin ADME Slc22a1 Abcg2 Alb Slco1a4 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%10224439 Electron transport from NADPH to Ferredoxin Fdx2 Fdxr Fdx1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224319 SRP-dependent cotranslational protein targeting to membrane LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Srp68 Srp9 Srp54 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Srp14 Rpl36al1 Rpl39l1 Srp19 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 PI METABOLISM%REACTOME%R-RNO-1483255.1 PI Metabolism Inpp5e Rab14 Ocrl Inpp5j Sacm1l Pi4ka Synj1 Pi4kb Pik3c2g Tpte2 Inpp5d Pik3ca Mtmr1 Pip5k1c Arf3 Arf1 Pik3r1 Sbf1 Pik3cb Pik3r2 Synj2 Pik3r3 Inppl1 Pik3cd Ptpn13 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Plekha8 Mtm1 Pik3r5 Fig4 Pik3cg Vac14 Mtmr12 Pi4k2a Pip4k2b Mtmr4 Pip4k2c Pik3r4 Pip4k2a Rab5a Pten Rab4a Pip5k1b Pip5k1a Mtmr14 Plekha6 Plekha5 Plekha4 Pip4p1 Plekha3 Plekha2 Plekha1 Mtmr3 Tnfaip8l2 Tnfaip8l3 Tnfaip8l1 Rufy1 Pitpnb Inpp5k Pik3c2b Bmx Tnfaip8 Mtmr7 Mtmr6 Mtmr9 Pik3r6 Gde1 Pnpla6 Enpp6 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%10222693 Porphyrin metabolism Gsta5 Slco2b1 Fabp1 Blvrb Hmox2 Blvra Abcg2 Abcc1 Hmox1 Abcc2 Ugt1a2 Ugt1a1 Ugt1a3 Ugt1a5 Alb Uros Alas1 Alas2 Hmbs Cpox Fech Alad Ppox Cox10 Cox15 Slco1b2 Urod TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%10222785 Toll Like Receptor 4 (TLR4) Cascade Cd180 Ly86 Ptpn4 Ppp2cb Ppp2ca Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Bpi Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Lbp Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Dnm2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Tirap Map2k3 Usp14 Tab3 Tab2 Dnm3 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Birc2 Optn Rps27a Ptpn11 Skp1 Uba52 Ube2d1 Btrc Plcg2 Ubb Ubc Dnm1 Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%10223569 Clearance of dopamine Maoa Tomt Slc6a3 Comt INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223091 Intestinal absorption Npc1l1 Slc2a2 Slc5a1 Slc2a5 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%10223081 Digestion of dietary carbohydrate Si Amy2 Lct Chia Chit1 KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 96%10224743 KEAP1-NFE2L2 pathway Keap1 Ufd1 Gsk3b Map1lc3b Crebbp Mul1 Srxn1 Prdx1 Nfe2l2 Prkci Sesn2 Psma4 Sesn1 Psma3 Akt3 Akt2 Sqstm1 Akt1 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Nploc4 Psmd14 Psmd13 Bach1 Skp1 Psmb5 Psmb4 Psmb7 Trim21 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Prkaa2 Psmd1 Ubxn7 Adrm1 Rbx1 Cul1 Vcp Cul3 NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly Hist1h2ai Itgb3bp Rsf1 Oip5 Mis18a Rbbp4 Cenpc Rbbp7 Cenpw Cenpa H2ac18 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Hist1h2bq Cenpm Cenpl Cenpk Cenpi Cenph Ruvbl1 Npm1 H2aj H2ab2 Hist3h2ba H2ac4 ENSRNOG00000068602 Knl1 Mis18bp1 Hjurp ENSRNOG00000066901 H2az2 Smarca5 H2bc4 Hist1h4m H2bc1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis Gnpat Dhrs7b Agps RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-RNO-380320.1 Recruitment of NuMA to mitotic centrosomes Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Numa1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Tubg2 Clasp1 Tubg1 Ywhae Cep63 Nme7 Cep152 Tuba4a Plk1 Tubgcp2 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Tubgcp6 Cdk1 Tubgcp5 Tubgcp4 Tubgcp3 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Mzt1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223911 activated TAK1 mediates p38 MAPK activation Ikbkg Map3k7 Ube2n Mapkapk3 Mapk14 Mapkapk2 Irak2 Irak1 Map2k3 Tab3 Tab2 Tab1 Nod2 Nod1 Mapk11 Map2k6 Traf6 Ripk2 PHOSPHORYLATION OF THE APC C%REACTOME%R-RNO-176412.1 Phosphorylation of the APC C Ccnb1 Plk1 Anapc10 Ube2d1 Anapc16 Ube2s Cdc16 Anapc15 Cdk1 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Anapc7 Ube2e1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223363 COPII-mediated vesicle transport Lman1 Scfd1 Lman2 Sec22a Tfg Rab1A Preb Napa Nsf Napb Napg Sec23a Sec23ip Sec16b Sec16a Lman2l Cnih1 Gorasp1 Cnih3 Cnih2 Ctsc Ppp6r3 Sar1b Tmed10 Col7a1 Tgfa Ppp6c Sec31b Areg Sec31a Gria1 Rab1b F8 Stx17 Trappc2l Gosr2 Lman1l Tbc1d20 Csnk1d Serpina1 Golga2 Uso1 Sec24d Trappc10 Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Tmed2 Folr1 Ankrd28 Cd59 Bet1 Sec13 Trappc6b Trappc6a Trappc9 Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Ctsz DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling Psmb6 Psmb1 Psmb3 Psmb2 Relb Uba52 Nfkb2 Fbxw11 Btrc Psma7 Psmc5 Psmc2 Ube2m Psmc1 Uba3 Psmc4 Psmc3 Map3k14 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Chuk Skp1 Psmb5 Psmb4 Psmb7 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%10225059 MET promotes cell motility Hgf Megf11 Itga2 Rac1 Ptk2 Met Crkl Src Rapgef1 Tns4 Tns3 Grb2 Lama4 Rap1a Rap1b Itgb1 Dock7 Itga3 Crk Gab1 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 96%10222371 C6 deamination of adenosine Adarb1 Adar INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224951 Intra-Golgi and retrograde Golgi-to-ER traffic Rab43 Tmf1 Sys1 Actr1a Golga1 Vps51 Vps52 Dctn1 Vps54 Arl1 Rab9a Gcc2 Dctn2 Rab9b Gcc1 Cog1 Cog2 Usp6nl Rab1A Dctn4 Stx6 Cog3 Ttgn1 Ric1 Cog4 Igf2r Arfgap3 Scoc M6pr Arfgap2 Vti1a Cog5 Vamp3 Rab18 Arfgap1 Vamp4 Cog6 Stx16 Cog7 Rgp1 Arfip2 Cog8 Rhobtb3 Napa Rabepk Nsf Arfrp1 Napb Galnt1 Galnt2 Napg Kif3a Kdelr2 Kdelr3 Copa Bet1l Kdelr1 Arf4 Arf3 Arf1 Copb2 Tmed10 Tmed9 Copb1 Cope Gosr1 Gosr2 Copz2 Copz1 Arf5 Actr10 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Arcn1 Trip11 Kif4b Kif4a Alpi Cyth2 Cyth3 Cyth4 Cyth1 Racgap1 Bnip1 Kif18b Kif19 Kif26b Kifc1 Snap29 Kifc2 Kif26a Kif11 Kif12 Kif15 Nbas Kif5a Rab36 Kif5b Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Kif6 Kif9 Pafah1b1 Zw10 Rab3gap2 Rab3gap1 Kif22 Rab1b Kif23 Kif28 Rint1 Kif27 Kif16b Bicd2 Kif18a Kif20a Bicd1 Klc1 Agpat3 Dync1h1 Kif20b Pafah1b3 Kifap3 Pafah1b2 Klc4 Klc3 Klc2 Dync1i2 Rab33b Dync1i1 Kif3b Kif3c Vps45 Stx18 Pla2g6 Cenpe Rab39a Kif2a Kif2b Use1 Kif2c Akp3 Dync1li2 Alpp Alpg Dync1li1 Dynll1 Pla2g4a Dynll2 Rab6b Rab6a Golga4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%10225023 PTK6 promotes HIF1A stabilization Egfr Gpnmb Lrrk2 Hbegf Hif1a Ptk6 FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation Itgb1 Fn1 Ceacam1 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-RNO-8874177.1 ATF6B (ATF6-beta) activates chaperones Mbtps1 Atf6b CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%10222703 Conjugation of carboxylic acids Glyatl3 Acsm2 Acsm4 Acsm5 Glyat PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 96%10225551 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Pelo Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps2 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 LOC134480579 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rpl23a Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Hbs1l Rps6 LOC100910714 LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism Aldh7a1 Phykpl Aadat Slc25a21 Gcdh Dld Dhtkd1 Pipox Crym Aass Hykk Dlst SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10224399 Synthesis of 15-eicosatetraenoic acid derivatives Alox15b Gpx4 Ptgs2 Alox15 Gpx2 Gpx1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%10222761 Transcription from mitochondrial promoters Polrmt Tfb2m Mterf1 Tfam EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%10222579 Effects of PIP2 hydrolysis Dgkq Prkch Prkce Dgkz Itpr3 Itpr2 Itpr1 Prkcq Prkcd Dgka Daglb Dgkb Abhd6 Trpc7 Dgkd Trpc3 Dgke Mgll Dgkg Abhd12 Dagla Dgkh Dgki Dgkk SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-RNO-9668328.1 Sealing of the nuclear envelope (NE) by ESCRT-III Tubb4b Tubb4a Tuba1a Tuba1c Tubal3 Chmp2b Tuba4a Cc2d1b Spast Tubb2b Tubb2a Ist1 Chmp3 Chmp7 Chmp6 Vps4a Tuba8 Chmp4c Tuba3b Chmp4bl1 Tubb6 Tubb3 Tubb1 Tuba1b Chmp2a EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 96%10223059 EGFR downregulation Spry1 Ereg Uba52 Ptpn12 Btc Ptpn3 Egf Eps15 Ubb Arhgef7 Ubc Hgs Eps15l1 Egfr Hbegf Spry2 Cbl Rps27a Stam2 Grb2 Epn1 Sh3gl3 Sh3kbp1 Tgfa Stam Cdc42 Sh3gl2 Areg Sh3gl1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%R-RNO-975577.1 N-Glycan antennae elongation St8sia6 Mgat4c Mgat4b B4galt2 B4galt3 St3gal4 B4galt4 B4galt5 B4galt6 St6gal1 Mgat5 Mgat4a St8sia2 St8sia3 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%10221953 TP53 Regulates Transcription of Cell Cycle Genes Cnot3 Cnot2 Ccnb1 Cnot1 Cnot7 Cnot6 Cnot4 Cnot9 Cnot8 Aurka Bax Cnot6l Plk2 Btg2 E2f7 E2f8 Npm1 Cdkn1b Gadd45a Ccna1 Cnot11 Pcna Cdc25c Ccna2 Cnot10 Cdk2 Cdk1 Ccne1 Ccne2 Tnks1bp1 Cpap Sfn Plk3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 96%10224393 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) F11r Uba52 Cgn Tgfbr1 Tgfbr2 Pard6a Rhoa Smurf1 Rps27a Prkcz Ubb Pard3 Ubc Tgfb1 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs Ppp2cb Ppp2ca Furin Pcsk5 Frs2 Ntrk1 Ngf Pcsk6 Plcg1 Ppp2r5d Creb1 Pik3ca Shc1 Rac1 Braf Ppp2r1b Ppp2r1a Mapk3 Crkl Pik3r1 Src Rapgef1 Rhoa Rps6ka5 Pik3cb Ntrk3 Nras Ntf3 Chd4 Pik3r2 Grb2 Fyn Rap1a Kras Dock3 Sos1 Hras Atf1 Mapk7 Irs2 Nab2 Dnal4 Egr2 Vrk3 Sgk1 Ntf4 Map2k2 Rps6ka3 Map2k1 Rps6ka1 Irs1 Bdnf Rps6ka2 Ntrk2 Dusp3 Ap2m1 Srf Dusp4 Clta Dusp7 Cltc Dusp6 Shc3 Shc2 Mapkapk3 Mapk14 Mapkapk2 Ap2s1 Mapk1 Ralgds Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Mapk11 Ywhab Crk Kidins220 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%10225075 MET activates STAT3 Hgf Stat3 Met NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10224537 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Wwox Tfap2c Tfap2a Ube2i Tfap2b Kctd1 Tfap2e Sumo1 BETA DEFENSINS%REACTOME%R-RNO-1461957.1 Beta defensins Tlr1 Defb14 Defb17 Defb18 Defb41 Ccr6 Defb42 Defb21 Tlr2 Defb5 Defb43 Defb44 Defb24 Defb1 Defb25 Defb28 Defb30 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225035 Regulation of RUNX1 Expression and Activity Cbfb Ccnd1 Ptpn11 Runx1 Cdk6 Ccnd2 Ccnd3 Pml TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 96%10222787 Toll-like Receptor Cascades Cd180 Ly86 Ptpn4 Ppp2cb Ppp2ca Tasl Eea1 Tlr10 Irf5 Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Apob Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Slc15a4 Nkiras2 Mapk8 Traf6 Peli1 Bpi Ikbkg Map3k8 Map3k7 Ube2n S100a1 Gsdme Lrrc14 Nfkb2 Tlr1 Gsdmd Nfkb1 Traf2 Tlr7 Cd36 S100a9 Ecsit Tlr6 Fbxw11 Lbp S100a8 Fos Vrk3 Tlr2 Ctsb Alpk1 Rela Ctss Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Dnm2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Tirap Map2k3 Usp14 Tab3 Tab2 Dnm3 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Unc93b1 Lgmn Tlr8 Cnpy3 Fgb Hsp90b1 Fga Fgg Birc2 Ctsk Ctsl Rbsn Tlr9 Optn Rps27a Ptpn11 Skp1 Pik3c3 Uba52 Pik3r4 Ube2d1 Btrc Plcg2 Ubb Ubc Dnm1 Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%10222813 Initial triggering of complement Fcn2 Fcn1 Mbl2 Masp1 Masp2 C4b C1qb Crp C1qa C2 C4 Colec10 C1s C1r C1qc ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C3 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%10224249 Synthesis of PE Chkb Selenoi Phospho1 Lpin3 Lpin2 Pcyt2 Cept1 Etnk2 Etnk1 Etnppl Chka PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224307 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Erbb2 Ppp2cb Ins2 Erbb3 Ppp2ca Ereg Frs2 Btc Il33 Pdgfa Ppp2r5d Pdgfb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Il1rap Irak4 Fgf17 Fgf18 Fgf19 Ppp2r1b Ppp2r1a Fgf10 Mapk3 Hbegf Src Ntrk3 Ntf3 Grb2 Fyn Tgfa Fgf20 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Lck Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Hgf Egfr Rhog Irak1 Rac2 Pdgfrb Pdgfra Kl Flt3 Esr1 Nrg2 Nrg3 Met Egf Pik3ca Insr Rac1 Gab2 Pip5k1c Akt1 Pik3r1 Pik3cb Cd19 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pik3r5 Pik3cg Irs2 Ier3 Pip4k2b Pip4k2c Pip4k2a Pik3ap1 Cd28 Icos Ntf4 Pip5k1a Strn Cd86 Cd80 Esr2 Bdnf Il1rl1 Trat1 Myd88 Ntrk2 Mapk1 Pik3r6 Ins1 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224045 Negative regulation of FGFR4 signaling Ppp2cb Ppp2ca Uba52 Frs2 Klb Fgf2 Fgf1 Fgf4 Fgf6 Ubb Fgf8 Ubc Fgfr4 Fgf9 Fgf16 Fgf17 Fgf18 Fgf19 Braf Ppp2r1a Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Fgf23 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%10223761 Synthesis, secretion, and deacylation of Ghrelin Igf1 Bche Mboat4 Ins2 Spcs3 Ghrl Spcs1 Spcs2 Pla2g7 Pcsk1 Gcg Lep Sec11c Gh1 Sec11a Ins1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME DATABASE ID RELEASE 96%10223199 Axonal growth inhibition (RHOA activation) Ngfr Mag Mcf2 Omg Arhgdia Rhoa Rtn4 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 96%10224179 Classical Kir channels Kcnj4 Kcnj2 Kcnj14 Kcnj12 VEGFA-VEGFR2 PATHWAY%REACTOME%R-RNO-4420097.1 VEGFA-VEGFR2 Pathway Pdpk1 Prkaca Ctnnb1 Prkacb Plcg1 Prkcd Prkca Cyba Cybb Mapk12 Rasa1 Trib3 Calm3 Itgb3 Vegfa Kdr Elmo2 Ptk2b Nckap1l Rock2 Rock1 Them4 Pxn Pik3ca Nck2 Rac1 Pak1 Cav1 Pak3 Pak2 Akt3 Baiap2 Ptk2 Akt2 Akt1 Pik3r1 Src Rhoa Pik3cb Hsp90aa1 Nras Vav3 Pik3r2 Fyn Vav1 Kras Vav2 Mapk13 Hras Abi2 Abi1 Sphk1 Nck1 Ncf1 Ncf2 Ncf4 Rictor Ctnna1 Prkcz Brk1 Prr5 Jup Shb Ctnnd1 Sh2d2a Elmo1 Mapkap1 Axl Bcar1 Wasf3 Wasf2 Shc2 Mapkapk3 Wasf1 Mapk14 Prkcb Mapkapk2 Mtor Nos3 Hspb1 Cdc42 Mapk11 Nckap1 Itgav Mlst8 Crk Cyfip2 Cyfip1 METALLOPROTEASE DUBS%REACTOME%R-RNO-5689901.1 Metalloprotease DUBs Hist1h2ai Uba52 Abraxas2 H2ac18 Babam1 Babam2 Brca1 Bard1 Uimc1 Ubb Ubc Nlrp3 Stambp Stambpl1 Ep300 H2ac4 ENSRNOG00000068602 Rps27a Psmd14 H2ac25 Mysm1 Stam Kat2b Brcc3 ABRAXAS1 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10225535 Interaction of NuRD complexes with transcription factors Hist1h2ai Rbbp4 Rbbp7 H2ac18 Hist1h2bq Hdac1 Hdac2 H2aj Nr2c2 H2ab2 Zmynd8 Ikzf3 Ikzf1 Zfp827 H3-3b Zfp532 Hist3h2ba H2ac4 ENSRNOG00000068602 Phf6 Chd3 Zfp592 Chd4 Cdk2ap1 Mbd2 Nr2f2 Mta1 H2bc18 Chd5 Mta2 Mta3 Tcf19 ENSRNOG00000066901 Mbd3 H2az2 H2bc4 Hist1h4m H2bc1 Zfp687 Gatad2a Gatad2b GAB1 SIGNALOSOME%REACTOME%R-RNO-180292.1 GAB1 signalosome Pxn Egfr Pik3ca Ereg Hbegf Btc Pag1 Src Pik3r1 Csk Grb2 Egf Ptpn11 Tgfa Areg Gab1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%10222733 Post-translational modification: synthesis of GPI-anchored proteins Fcgr3a Alpi Folr2 Lypd6b Rtn4rl2 Gpld1 Lypd8 Tecta Lypd5 Lypd4 Pign Lypd3 Pigq Negr1 Pigp Tex101 Pigw Lypd2 Pigv Lypd1 Pigx Pigc Alpl Pigb Opcml Tectb Dpm2 Piga Dpm1 Pigm Dpm3 Pigl Otoa Pigg Izumo1r Pigf Ly6g6d Pigh Cd52 Prss21 Nrn1 Ntm Pigs Gp2 Pigu Xpnpep2 Pigt Thy1 Gpaa1 Pigk Art4 Plaur Meltf Art3 Atrnl1 Pgap1 Lsamp Reck Psg29 Sprn Plet1 Psca Spaca4 Cntn4 Mdga1 Cntn3 Mdga2 Cntn5 Ly6e Gpihbp1 Ly6h Prnd Ly6d Prss41 Bst1 Ceacam6 Vnn1 Cd109 Cgm4 Msln Akp3 Psgb1 Alpp Alpg Ceacam1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10222065 Neurotransmitter release cycle Slc1a1 Slc18a3 Slc38a2 Slc1a7 Slc1a6 Gls2 Slc6a12 Stx1a Dnajc5 Slc22a2 Vamp2 Slc22a1 Slc32a1 Slc6a11 Slc6a13 Aldh5a1 Naaa Slc17a7 Slc6a1 Abat Syn3 Syn2 Syn1 Cask Chat Lin7a Lin7b Lin7c Gls Gad1 Gad2 Hspa8 Apba1 Arl6ip5 Rab3a Slc5a7 Slc1a3 Slc1a2 Rims1 Maoa Tspoap1 Syt1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%10224009 Calnexin calreticulin cycle Rps27a Canx Calr Uba52 Pdia3 Ubb Ubc PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%10223405 Platelet sensitization by LDL Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Mapk14 Ptpn6 Ppp2r1b Ppp2r1a Fgr Ppp2r5e Pla2g4a Apob Ptpn11 Ppp2r5d Pecam1 Lrp8 TRIGLYCERIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10223079 Triglyceride catabolism Fabp9 Fabp5 Fabp1 Fabp2 Fabp3 Fabp4 Fabp7 Fabp6 Pnpla5 Pnpla4 FABP12 Gpd2 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855229.1 IP6 and IP7 transport between cytosol and nucleus Nup133 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%10223039 Signaling by FGFR3 Ppp2cb Ppp2ca Uba52 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf5 Ubb Fgf8 Fgfr3 Ubc Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Braf Ppp2r1a Mapk3 Src Spry2 Pik3r1 Mknk1 Cbl Nras Mapk1 Rps27a Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Galnt3 Gab1 REELIN SIGNALLING PATHWAY%REACTOME%R-RNO-8866376.1 Reelin signalling pathway Fyn Vldlr Sh3kbp1 Reln Dab1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-RNO-159231.1 Transport of Mature mRNA Derived from an Intronless Transcript Nup133 Cpsf1 Nup210 Ncbp2 Cpsf2 Nup155 Ncbp1 Cpsf3 Nup153 Nup93 Nup50 Alyref Nxf1 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Fip1l1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Sympk Aaas Eif4e Ranbp2 Cpsf4 Nup214 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling Pik3r5 Pik3cg Map3k8 Pdpk1 Cd28 Rictor Cd86 Cd80 Prr5 Map3k14 Trib3 Lck Mapkap1 Them4 Pik3ca Mtor Akt3 Akt2 Akt1 Pik3r1 Pik3cb Pik3r2 Fyn Pik3r3 Pik3cd Pik3r6 Mlst8 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 96%10222937 Downregulation of SMAD2 3:SMAD4 transcriptional activity Tgif1 Tgif2 Atp1b4 Parp1 Uba52 Ppm1a Smad2 Ube2d1 Ncor2 Smad3 Smad4 Trim33 Mapk3 Ski Mapk1 Rps27a Ube2d3 Ubb Usp9x Hdac1 Ubc Skil Smurf2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224163 PI3K events in ERBB4 signaling Pik3ca Ereg Nrg2 Nrg3 Hbegf Btc Pik3r1 SIGNALING BY WNT%REACTOME%R-RNO-195721.1 Signaling by WNT Gsk3b Ctnnb1 Sox3 Wnt5a Sox9 Sox7 Gnat2 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Tnks2 Hecw1 Xiap Klhl12 Axin1 Axin2 Rnf43 Tcf7 Dvl1 Dvl2 Wnt11 Gnao1 Dvl3 Nlk Sox13 Tcf7l1 Fzd3 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Sox17 Fzd8 Bcl9l Bcl9 Cdc73 Rnf146 Cby1 Znrf3 Ctbp1 Kras Amer1 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Wnt8b Smurf2 Wnt8a Ppp2r5b Sry3 Ppp2r5a Lef1 Dact1 Map3k7 Sry Leo1 Ryk Ctnnbip1 Apc Lgr5 Lgr6 Frat2 Pip5k1b Frat1 Ppp2r5e Daam1 Ppp3ca Ppp3cb Nfatc1 Ppp3r1 Prkcb Ap2s1 Pfn1 Ap2a2 Ap2a1 Ap2b1 Rac3 Rac1 Psma4 Psma3 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Gng10-ps1 Snx3 Zranb1 Ppp2cb Ppp2ca Prkcg Prkca Calm3 Ppp2r5d Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Ppp2r1b Ppp2r1a Gnb2 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Camk2a Arrb2 Vps26a Vps35 Vps29 Wnt10a Wnt10b Wls Fzd7 Wnt9a Wnt9b Wnt7a Tmed5 Wnt5b Ror1 Ror2 Wnt6 Wnt2 Wnt4 Wnt2b Wnt16 Prickle1 Pard6a Rac2 Crebbp Kmt2b Ctbp2 Csnk2a2 Csnk2a1 Dkk4 Kremen2 Kremen1 Hdac1 Wdr5 Lrp6 Ash2l Sost Dkk1 Dkk2 Csnk2b Cav1 Smarca4 Ep300 Rbbp5 Pde6g Xpo1 Pde6a Pde6b Csnk1a1 Ap2m1 Clta Cltb Cltc Rbx1 Smurf1 Cul3 Csnk1e Ywhaz BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation Hist1h2ai Neil2 H2ac18 Neil1 Hist1h2bq Terf2 Neil3 Acd Terf1 Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 ENSRNOG00000068602 Mbd4 Smug1 Nthl1 Tdg Ung ENSRNOG00000066901 H2az2 H2bc4 Hist1h4m H2bc1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%10222977 Glutathione synthesis and recycling Cndp2 Gclm Chac1 Ggt1 Ggt5 Chac2 Ggt7 Ggt6 Ggct Gss Gclc Oplah MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222633 Mitotic Spindle Checkpoint Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Ube2s Pafah1b1 Ube2c Zw10 Knl1 Cdc27 Cdc26 Ska2 Cdc23 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Anapc10 Ube2d1 Incenp Bub1b Dync1i2 Ndel1 Anapc16 Dync1i1 Cenpc Anapc15 Cenpa Aurkb B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Anapc5 Cenpt Cenpq Anapc4 Cenpp Anapc1 Cenpo Anapc2 Cenpn Cenpm Mis12 Anapc7 Cenpl Cenpk Cenpi Ube2e1 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Cdc16 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-RNO-6799990.1 Metal sequestration by antimicrobial proteins Ltf S100a9 S100a8 Lcn2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-RNO-2555396.1 Mitotic Metaphase and Anaphase Spdl1 Nup133 Nup155 Bub1 Itgb3bp Zwilch Emd Tuba1b Ppp2r5b Ppp2r5a Vrk2 Ppp1cc Ppp2r5e Tuba1a Kpnb1 Tuba1c Tubal3 Rcc1 Tuba4a Chmp2b Cc2d1b Spast Tubb2b Tubb2a Ist1 Hdac8 Chmp3 Vrk1 Chmp7 Chmp6 Lmna Vps4a Sirt2 Tuba8 Chmp4c Tuba3b Chmp4bl1 Tubb6 Tubb3 Tubb1 Banf1 Ran Ankle2 Tubb4b Tubb4a Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Chmp2a Psmb6 Ppp2r2a Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 Lbr Ppp2cb Ppp2ca Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ube2i Espl1 Smc3 Sumo1 Stag2 Stag1 Smc1a Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Sec13 Kif2a Kif2b Kif2c Nup188 Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 PHENYLALANINE METABOLISM%REACTOME%R-RNO-8964208.1 Phenylalanine metabolism Asrgl1 Pcbd1 Qdpr Kyat1 Pah Il4i1 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 96%10223381 Regulation of KIT signaling Ptpn6 Lyn Yes1 Kitlg Src Cbl Prkca Sh2b2 Grb2 Fyn Sos1 Lck Kit PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223683 Prostacyclin signalling through prostacyclin receptor Ptgir TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors Tspan7 Grip2 Grip1 Prkcb Prkcg Ap2s1 Prkca Gria4 Gria3 Ap2a2 Gria2 Ap2a1 Nsf Ap2b1 Pick1 Gria1 Ap2m1 MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing Apobec1 Adarb1 Adar A1cf Apobec4 Apobec2 Apobec3 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%10222527 Activation of caspases through apoptosome-mediated cleavage Casp3 Casp7 Cycsl2 Casp9 Apaf1 Cycs Xiap EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 96%10222139 Eukaryotic Translation Initiation LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Eif5 Rps14 Eif2b3 Rps15 Eif2b2 Rps16 Eif2s3 Rps17 Eif2b5 Rpl4 Rps15a Eif2b4 Rpl5 Rps18 Eif2s2 Rpl3 Rps19 Eif2b1 Rps27 Pabpc1 Eif2s1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Eif4h Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Eif4a2 Eif4a1 Eif5b Fau Eif4ebp1 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 Eif4e BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10225261 Blood group systems biosynthesis B3galt1 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 St6galnac6 Abo2 St3gal6 St3gal4 St3gal3 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-RNO-8951430.1 RUNX3 regulates WNT signaling Runx3 Lef1 Tcf7l1 Tcf7l2 Ctnnb1 Tcf7 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%10224725 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Hist1h2ai H2aj Kdm4c Ncoa2 H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 Ar H2bc4 Hist1h4m Kdm1a H2bc1 Pkn1 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 96%10224919 FGFR2 alternative splicing Polr2j Ncbp2 Ncbp1 Hnrnpa1 Hnrnph1 Gtf2f2 Rbfox2 Gtf2f1 Esrp2 Esrp1 Tial1 Ptbp1 Tia1 Polr2c Hnrnpf Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2i MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis Hsd3b1 Hsd3b5-ps1 Hsd3b Lhb Cga Hsd3b6 Cyp21 Hsd3b5 Cyp11b3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224033 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling Irf7 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%10224679 Transcriptional regulation by small RNAs Polr2j Hist1h2ai H2ac18 Ago2 Ago1 Hist1h2bq Ipo8 H2aj H2ab2 H3-3b Hist3h2ba Tnrc6a H2ac4 ENSRNOG00000068602 Polr2c Polr2a Polr2b H2bc18 Polr2g Polr2h ENSRNOG00000066901 H2az2 Polr2e Ran Polr2f H2bc4 Hist1h4m Polr2i H2bc1 TP53 REGULATES METABOLIC GENES%REACTOME%R-RNO-5628897.1 TP53 Regulates Metabolic Genes Ywhag Cox5a Cox5b Ndufa4 Ddit4 Higd1c Prkab2 Prkab1 Prdx2 Prdx5 Gls2 Cox4i1 Cox4i2 Prdx1 Sesn2 Txnrd1 Sesn1 Akt3 Sesn3 Akt2 Akt1 Gsr Tigar Cox6a1 Tsc2 Cox6a2 Tsc1 Sfn Cox6c2 Cox7a1 Cox7a2 Gls Cox7a2l Cox6b1 Cox6b2 G6pdx Lamtor3 Lamtor2 Txn Ywhae Rptor RragB Prkaa1 Mt-co3 Gpi Prkaa2 Mt-co2 Cycsl2 Mtor Cox8a Rheb Cox8c Cox7b Slc38a9 Lamtor5 Cox7c Lamtor4 Prkag3 Rraga Prkag1 Mt-co1 Prkag2 Lamtor1 Rragc Ywhaq Rragd Ywhah Cycs Ywhab Mlst8 Gpx2 Ywhaz AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-RNO-211163.1 AKT-mediated inactivation of FOXO1A Foxo1 Akt3 Akt2 Akt1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%10222171 RNA Polymerase I Transcription Initiation Gtf2h2 Gtf2h1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Rbbp4 Ercc3 Rbbp7 Ttf1 Polr1c Mnat1 Hdac1 Hdac2 Tbp Polr1b Polr1a Ccnh Polr1f Polr1g Polr1e Polr1h Chd3 Chd4 Taf1d Rrn3 Taf1a Taf1c Taf1b Mta1 Mta2 Polr2h Mta3 Mbd3 Polr2e Polr2f Ercc6 Ubtf Gatad2a Gatad2b CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-RNO-373076.1 Class A 1 (Rhodopsin-like receptors) Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 App Ednrb Ednra Rrh Ptgdr Htr4 Apln Trhr Htr6 Oprd1 Htr7 C3ar1 Galr2 Galr3 Galr1 Cmklr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Tbxa2r Gpr183 Ppbp Fpr1 Gnrh1 Nmbr Fpr2 Ccr10 C3 Nln C5 Ptgfr Pnoc Ppy Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Nmu Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger4 Ptger2 Ptger3 Fshr Ptger1 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Mtnr1b Agtr1 Agtr2 F2 Gpha2 Gpr37 Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Kiss1r Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ptgdr2 Rho Pf4 Cx3cl1 Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Ptgdrl Ccl27 Npsr1 Prok1 P2ry10 Pdyn Mc3r P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 F2rl1 Fpr2l1 F2rl2 F2rl3 Hcar1 Prokr2 Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Oprm1 Gpr68 Cxcr4 Cxcr5 Oprl1 Adrb2 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Pomc Tacr1 Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Cxcl10 C5ar2 F2r C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Chrm1 Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Adra2a Opn5 Adora2b Sucnr1 Lhb Pyy Adora2a Cga Adora1 Adra2c Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Opn1sw Prlhr Oxt Ece1 Ece2 Trh P2ry2 Npy5r Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Insl3 Ptgir Psap Htr1d Htr1f Xcl1 Htr1b Htr1a Agt Kiss1 Tshr Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Uts2b Npffr1 Npffr2 Gpr37l1 Npff Ackr3 Hcrtr2 Ackr4 Hcrtr1 Cck Qrfprl Cnr1 Qrfpr Ackr2 Qrfp Cnr2 Hcrt Uts2r Taar8c Sst Oprk1 Tshb PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%10223635 Peroxisomal lipid metabolism Acoxl Phyh Abcd1 Amacr Eci2 Hacl1 Mlycd Scp2 Crat Acox1 Acox2 Ehhadh Acox3 Acaa1b Hsd17b4 Hao2 Pecr Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Acbd4 Nudt19 Acot4 Acot8 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 96%10224229 Collagen formation Plod1 Plod2 Loxl2 Adamts3 Bmp1 Adamts2 Loxl1 Loxl4 Col15a1 Loxl3 Col13a1 Col19a1 Ctsl Lox Col25a1 Col4a1 Col4a2 Adamts14 P4hb Col7a1 Tll2 Tll1 Ctsb Ctss Gpr162 Col14a1 Col10a1 Ppib Col1a2 Mmp7 Col3a1 Col28a1 Mmp3 Col22a1 Col5a2 Col5a3 Col24a1 Mmp9 Col4a4 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 P3h1 Pxdn Crtap Col18a1 Pcolce2 Colgalt2 Col2a1 Col27a1 Col6a2 Serpinh1 Col23a1 Mmp20 Col6a5 Col6a6 Col26a1 Col4a5 Col6a3 Mmp13 Col8a1 Col4a6 Col8a2 Plod3 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%10224471 Sensory perception of taste Tas2r16 Tas2r13 Tas2r136 Tas2r140 Tas2r105 Tas2r107 Tas2r119 Tas2r39 Tas2r4 Tas2r38 Tas2r3 Tas2r7 Gnat3 Itpr3 Scnn1a Scnn1b Gnb1 Scnn1g Gnb3 Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r40 Tas2r41 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 96%10224771 SHC-mediated cascade:FGFR2 Fgf16 Fgf17 Shc1 Fgf18 Fgf10 Nras Grb2 Kras Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Fgfr2 ION CHANNEL TRANSPORT%REACTOME%R-RNO-983712.1 Ion channel transport Mcoln2 Clcn6 Clcn7 Clcn4 Clcn5 Calm3 Atp2a1 Atp2a3 Atp7a Atp2a2 Trpc7 Trpc3 Atp2b1 Camk2g Atp2b4 Camk2d Atp2b3 Camk2b Sri Camk2a Wwp1 Atp1b1 Atp1b3 Atp1b2 Ryr2 Ryr1 Fkbp1b Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Pln Asph Stom Trpc1 Raf1 Ano6 Ano5 Clcn2 Clcn1 Ano10 Ttyh3 Ttyh1 Ttyh2 Slc17a3 Trpc4ap Atp9b Atp9a Best4 Atp6v0b Atp6v0a4 Best1 Best3 Atp6v1g3 Atp6v0e2 Atp6v1c2 Best2 Atp6v0a1 Atp6v1c1 Atp7b Clca1 Atp6v0c Clca2 Clca4 Trpc5 Trpc4 Atp6ap1 Stoml3 Unc80 Atp6v1e2 Atp6v1e1 Tcirg1 Atp2c1 Atp6v1a Atp6v1b2 Atp2c2 Scnn1a Atp6v0d2 Atp6v0d1 Atp6v1b1 Scnn1b Atp6v0e1 Unc79 Atp6v1g2 Scnn1g Atp6v1g1 Lrrk1 Atp6v1f Rps27a Trpa1 Atp6v1d Tpcn1 Bsnd Mcoln1 Atp4a Atp4b Trpm2 Trpm1 Nek4 Uba52 Ano9 Ano8 Trpm8 Trpm7 Ano7 Trpm4 Ano4 Sgk1 Trpm3 Ano3 Trpm6 Ano2 Ano1 Sgk3 Sgk2 Asic5 Asic4 Atp10a Ubb Atp10b Atp10d Ubc Asic1 Asic3 Asic2 Atp11b Atp11a Atp11c Atp13a1 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a Trpv5 Trpv4 Trpv6 Trpv1 Trpv3 Trpv2 Nalcn Tsc22d3 Clcnkb Clcnka Mcoln3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling Rhoc Erbb2 Rac1 Rnd1 Rhob Rras Met Arhgef11 Rhoa Sema4d Arhgap35 Plxnb1 Arhgef12 Rock2 Rock1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%10223323 Formation of the beta-catenin:TCF transactivating complex Lef1 Leo1 Crebbp Ctnnb1 Kmt2b Pygo2 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Hdac1 Tcf7 Wdr5 Ash2l Tcf7l1 Tcf7l2 Smarca4 Ep300 Bcl9l Bcl9 Cdc73 Rbbp5 Tert INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling Jak3 Grb2 Shc1 Sos1 Stat3 Il2rb Il15 Il15ra Sos2 Stat5a Stat5b PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%10223333 Phosphorylation of CD3 and TCR zeta chains Pag1 Ptprc RT1-Db2 Cd3g Cd247 Csk RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Ptpn22 RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10223445 Acetylcholine Neurotransmitter Release Cycle Rims1 Tspoap1 Syt1 Stx1a Ppfia3 Ppfia2 Ppfia4 Chat Ppfia1 Stxbp1 Unc13b Snap25 Cplx1 Slc18a3 Vamp2 Rab3a Slc5a7 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-RNO-5626978.1 TNFR1-mediated ceramide production Nsmaf Rack1 Smpd2 Smpd3 Tnf Tnfrsf1a COMPLEX III ASSEMBLY%REACTOME%R-RNO-9865881.1 Complex III assembly Nfs1 Uqcrb Fxn LOC120097699 Uqcrh Uqcr10 Ttc19 Hspa9 Hscb Mt-cyb Uqcrfs1 Lyrm7 Iscu Uqcrc2 Uqcrc1 Uqcrq Cyc1 Lyrm4 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation Suz12 Eed Nedd4 Rbbp4 Rbbp7 Tnks2 Xiap Usp7 Mkrn1 Stub1 Rnf146 Tnks Wwp2 Otud3 Pten Usp13 Lamtor3 Lamtor2 Hdac2 Ring1 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Prex2 Csnk2a2 Trim27 Csnk2a1 Bmi1 Hdac1 Maf1 Mecom Sall4 Csnk2b Psma4 Akt3 Psma3 Akt2 Akt1 Psma6 Psma5 Rnf2 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Psmb5 Gatad2a Psmb4 Gatad2b Psmb7 Pml Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Frk Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Rptor Psmd6 RragB Psmd8 Psmd2 Mtor Psmd1 Adrm1 Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Rragc Rragd Ezh2 Mlst8 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-RNO-933541.1 TRAF6 mediated IRF7 activation Crebbp Irf3 Irf7 Ep300 ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222329 Arachidonate metabolism Alox12b Cyp8b1 Akr1c18 Abcc1 Akr1c12l1 Akr1c19 Akr1c21 Ggt1 Ggt5 Akr1c3l1 Cyp2u1 Akr1c12 Hpgds Akr1c1 Akr1c13 Ltc4s Dpep1 Akr1c9 Dpep2 Faah Pon2 Alox15b Alox12 Alox5ap Cyp1b1 Gpx4 Alox5 Lta4h Alox15 Cyp2c66 Cyp2c11 Cbr1 Cyp1a1 Tbxas1 Ephx2 Ptges Ptgds Cyp1a2 Ptgis Ptges2 Awat1 Ptgs1 Ptgs2 Pon3 Pon1 Ptges3 Mapkapk2 Cyp2j16 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Pla2g4a Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Cyp4f4 Cyp4a10 Cyp4a2 Gpx2 Aloxe3 Gpx1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-RNO-3928662.1 EPHB-mediated forward signaling Grin1 Grin2b Arpc3 Arpc2 Actb Arpc5 Arpc4 Rasa1 Actg1 Rock2 Rock1 Tiam1 Pak1 Rac1 Ptk2 Lyn Yes1 Src Rhoa Arpc1b Actr2 Arpc1a Actr3 Fyn Itsn1 Hras Arhgef28 Cdc42 Sdc2 Kalrn SEPARATION OF SISTER CHROMATIDS%REACTOME%R-RNO-2467813.1 Separation of Sister Chromatids Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Espl1 Hdac8 Smc3 Stag2 Stag1 Smc1a Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Pafah1b1 Ube2c Zw10 Psmd14 Knl1 Psmd13 Cdc27 Cdc26 Ska2 Cdc23 Ska1 Zwint Cdc20 Rps27 Psmb5 Rcc2 Psmb4 Kif18a Psmb7 Nudc Psmb6 Dync1h1 Spc24 Psmb1 Spc25 Psmb3 Xpo1 Psmb2 Uba52 Mad2l1 Nuf2 Cdca8 Anapc10 Ube2d1 Incenp Bub1b Dync1i2 Ndel1 Anapc16 Dync1i1 Psma7 Cenpc Anapc15 Cenpa Aurkb B9d2 Psmc5 Ska2l1 Psmc2 Taok1 Psmc1 Nde1 Psmc4 Mad1l1 Psmc3 Cenpu Anapc5 Cenpt Cenpq Anapc4 Cenpp Anapc1 Cenpo Anapc2 Cenpn Cenpm Ubb Mis12 Anapc7 Cenpl Ubc Cenpk Cenpi Ube2e1 Nup98 Cenph Psmb6l1 Cenpf Cenpe Clasp1 Psmd7 Clasp2 Rangap1 Psmd6 Nup37 Psmd8 Clip1 Plk1 Sgo2 Psmd2 Sgo1 Pttg1 Nup107 Psmd1 Kif2a Sec13 Adrm1 Kif2b Kif2c Dync1li2 Cdc16 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation Hsbp1 Rptor Fkbp4 Hspa2 Hsp90ab1 Ptges3 Crebbp Mtor Hspb8 Hspa8 Ep300 Hsp90aa1 Hsf1 Akt1s1 Hspa1b Camk2g Hspa1a Camk2d Camk2b Dnajb1 Cryab Hspa1l Mlst8 Camk2a THE FATTY ACID CYCLING MODEL%REACTOME%R-RNO-167826.1 The fatty acid cycling model Slc25a14 Ucp1 Ucp2 Ucp3 Slc25a27 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Ccnc E2f5 Uba52 Furin Tfdp2 Tfdp1 Smad2 Smad3 Smad4 Mapk3 Smad7 Rbl1 Ccnk Mapk1 Rps27a Ccnt2 Men1 Cdk9 Wwtr1 Sp1 Ubb Ubc Rnf111 E2f4 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%10222623 Amine Oxidase reactions Maob Maoa Smox ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224961 ERBB2 Activates PTK6 Signaling Egfr Erbb2 Egf Erbb3 Ereg Nrg2 Nrg3 Hbegf Btc Ptk6 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-RNO-418594.1 G alpha (i) signalling events Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Lpar5 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 App Rrh Apln Tas2r39 Oprd1 Tas2r38 C3ar1 Galr2 Galr3 Galr1 Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Rxfp3 Htr5a Gpr183 Ppbp Fpr1 Tas1r2 Tas1r1 Fpr2 Ccr10 Tas1r3 C3 C5 Pnoc Tas2r16 Tas2r13 Ppy Tas2r135 Tas2r136 Gpr18 Gpr17 Nms Tas2r140 Nmu Tas2r145 Npbwr1 Nmur2 Nmur1 Tas2r4 Tas2r3 Tas2r7 Gabbr1 Ptger3 Gabbr2 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Mtnr1b Agtr2 Gpr37 Gal Penk Rgr Npb Opn1mw Ccl19 Ccl11 Npw Npy Ptgdr2 Rho Pf4 Cx3cl1 Fpr2l3 Ccl27 Plcb4 Plcb3 Mapk1 Pla2g4a Pdyn Plcb2 P2ry13 Plcb1 P2ry12 Ccl20 Ppp1r1b Gng10-ps1 Gpr55 Adcy3 Ccl21 Adcy4 P2ry14 Adcy1 Adcy2 Tas2r40 Camkk1 Adcy7 Fpr2l1 Tas2r41 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Hcar1 Ppp2cb Adra2b Ppp2ca Adcy9 Hcar2 Pde4a Cxcr1 Pde4b Cxcr2 Prkaca Cxcr3 Prkacb Prkcg Npy1r Prkcd Oprm1 Gnai2 Gnai1 Cxcr4 Prkca Cxcr5 Gnai3 Oprl1 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Ppp2r5d Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Anxa1 Gnaq Cxcl11 Gng7 Hebp1 Pde4d Gng8 Gngt1 Cxcl12 Casr Gnat3 Prkar2a Cxcl10 Prkar2b Ppp2r1b Ppp2r1a C5ar1 Cdk5 Pde1b Aplnr Pde1c Bdkrb2 Gnb2 Bdkrb1 Gnb1 Src Pde1a Gnb4 Kng1 Gnb3 Gnb5 Gng11 Chrm2 Hrh4 Chrm4 Drd3 Drd4 Opn3 Pmch Gper1 Oxgr1 Adra2a Opn5 Sucnr1 Pyy Adora1 Adra2c Adora3 Rln3 Cxcl16 Cxcl13 Tas2r119 Opn1sw Npy5r Grm3 Grm2 Grm4 Grm7 Grm6 Grm8 Npy4r Cx3cr1 Psap Htr1d Htr1f Tas2r120 Htr1b Agt Ccl9 Cxcl9 P2ry4 Ccl6 Ccl5 Ccl4 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Tas2r105 Tas2r107 Gpr37l1 Ackr3 Cnr1 Cnr2 Sst Oprk1 Rgs9 Gnat1 Rgs20 Rgs17 Rgs16 Rgs4 Rgs5 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events Grin1 Grin2d Grin2c Rps6ka6 Grin2b Camk1 Prkaca Prkacb Rps6ka3 Camk4 Rps6ka1 Prkar1a Prkar1b Rps6ka2 Calm3 Creb1 Prkar2a Prkar2b Grin3a Grin2a Lrrc7 Gria4 Gria3 Camk2g Camk2d Gria2 Camk2b Dlg1 Dlg2 Gria1 Actn2 Camkk1 Dlg3 Dlg4 Camk2a Camkk2 Nefl CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856828.1 Clathrin-mediated endocytosis Arf6 Ereg Wnt5a Btc Ttgn1 Igf2r M6pr Vamp3 Arfgap1 Adrb2 Vamp4 Nedd8 Grk2 Tacr1 Itsn2 Hgs Dvl2 Slc2a8 Fzd4 Hbegf Grb2 Stam2 Gps1 Apob Chrm2 Vamp2 Tgfa Trip10 Areg Lrp2 Arrb2 Arrb1 Il7r Cops4 Arpc3 Cops2 Arpc2 Cd3g Arpc5 Arpc4 Picalm Eps15 Cd3d Dnm2 Cd4 Avpr2 Egfr Syt1 Actr2 Ap2s1 Arpc1a Actr3 Dnm3 Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Slc18a3 Ocrl Egf Bin1 Synj1 Snx18 Ston1 Ston2 Eps15l1 Tor1a Tor1b Scarb2 Pip5k1c Ldlr Fnbp1 Cops3 Cops6 Cops8 Aak1 Synj2 Rps27a Syt11 Tf Itsn1 Sh3gl3 Sh3kbp1 Tfrc Dnajc6 Agtr1 Sh3gl1 Fnbp1l Pik3c2a Ldlrap1 Fcho1 Vamp7 Fcho2 Vamp8 Uba52 Rab5a Necap2 Necap1 Avp Hspa8 Hip1r Agfg1 Snx9 Cops7a Cops7b Hip1 Gapvd1 Gak Ubb Ubc Ap2m1 Pacsin1 Clta Pacsin3 Cltb Pacsin2 Cltc Dab2 Grk3 Dnm1 Amph Snap91 Syt2 Syt9 Syt8 Ubqln2 Cbl Ubqln1 Epn2 Epn1 Reps1 Reps2 Cops5 Stam Rab5c Rab5b Cftr NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224043 Negative regulation of FGFR2 signaling Ppp2cb Ppp2ca Uba52 Frs2 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Fgf7 Ubc Fgf9 Fgfr2 Fgf16 Fgf17 Fgf18 Braf Ppp2r1a Fgf10 Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Fgf23 Fgf22 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%10224251 Synthesis of PI Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 96%10222757 Cytoprotection by HMOX1 Cox7a2 Cox5a Cox5b Fabp1 Ncoa2 Blvrb Hmox2 Blvra Tbl1x Ndufa4 Crebbp Abcc1 Hmox1 Cox7a2l Hba1 Cox6b1 Higd1c Hbb Ppara Cox6b2 Sin3a Sin3b Hdac3 Alb Tbl1xr1 Cox4i1 Cox4i2 Hm13 Mt-co3 Mt-co2 Cycsl2 Ncor2 Carm1 Cox8a Tgs1 Cox8c Cox7b Cox7c Smarcd3 Mt-co1 Cox6a1 Cox6a2 Cycs Med1 Cox6c2 Cox7a1 Rxra HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%10224553 HSP90 chaperone cycle for SHRs Stip1 Dync1h1 Actr1a Pgr Dctn1 Actr10 Dctn2 Dync1i2 Dctn4 Dync1i1 Hspa8 Dnaja1 Hspa1b Hspa1a Hspa1l Fkbp4 Hspa2 Hsp90ab1 Fkbp5 Ptges3 Dync1li2 Hsp90aa1 Dync1li1 Dnaja2 Dnaja4 Dynll1 Dynll2 Dnajb1 Ar Nr3c2 Nr3c1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs Gpx4 Ptgs2 Hpgd Alox5 Lta4h Alox15 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%10224115 ISG15 antiviral mechanism Eif2ak2 Ube2n Stat1 Isg15 Nedd4 Irf3 Rig1 Plcg1 Mapk3 Becn1 Flnb Usp18 Ube2l6 Ppm1b Mx2 Arih1 Trim25 Uba7 Ube2e1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 96%10221955 Transcriptional Regulation by TP53 Ywhag Cox5a Zfp385a Cox5b Pdpk1 Ttc5 Pou4f1 Rbbp4 Rbbp7 Pou4f2 Prkab2 Prkab1 Gls2 Cox4i1 Cox4i2 Gadd45a LOC134478826 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Banp Map2k6 Lamtor3 Lamtor2 Txn Hdac2 Mapk14 Cycsl2 Cpap Cycs Mapk11 Ywhab Gpx2 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Txnrd1 Ccna1 Akt3 Akt2 Ccna2 Akt1 Gsr Chd3 Rps27a Ccne1 Chd4 Ccne2 Steap3 Tsc2 Tsc1 Mta2 Mbd3 Gatad2a Gatad2b Ccnb1 Uba52 Aurka Aurkb Cdk9 Rpa1 Rpa2 Rpa3 Ubb Chm Ubc Npm1 Cdkn1b Ywhae Rptor RragB Mt-co3 Mt-co2 Mtor Rheb Cdk2 Cdk1 Slc38a9 Lamtor5 Lamtor4 Rraga Mt-co1 Lamtor1 Rragc Rragd Stk11 Mlst8 Ppp2cb Ppp2ca Ddit4 Higd1c Plk2 Igfbp3 Tmem219 Btg2 Cdk5r1 Usp2 Brpf3 Usp7 Sesn2 Ppp2r1b Ppp2r1a Sesn1 Cnot11 Cdk5 Sesn3 Cnot10 Tp53rkb Tp53rka Tnks1bp1 Blm Wrn Dna2 Cox7a1 Cox7a2 Mre11 Eloc Kat5 Elob Nbn Cox7a2l Hus1 Atrip Cnot6l Rffl Chek1 Chek2 Cradd Pidd1 Rad9a Rad9b Bard1 Tpx2 Top3a Tp63 Tp53 Rad17 Rfc5 Ccng1 Rfc3 Rfc4 Pcna Ccnh Atm Kmt5a Rfc2 Atr Exo1 Rmi2 Rmi1 Brip1 Tp73 Jmy Rhno1 Dyrk2 Ndufa4 Cdk7 Rad50 Ehmt1 Daxx Ing2 Bax Ing5 Csnk2a2 Brd1 Topbp1 Rbbp8 Csnk2a1 Mnat1 Brca1 Prdx2 Brd7 Prdx5 Rad1 Hdac1 Smyd2 Prdx1 L3mbtl1 Csnk2b Tp53bp2 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Brpf1 Taf12 Tbp Taf4b Kat6a Taf7l-ps1 Ep300 Noc2l Meaf6 Taf8 Taf7 Tigar Taf6 Taf5 Hipk1 Cox6a1 Taf4 Cox6a2 Taf2 Taf1 Rabggta Rabggtb Ppp1r13l Sfn Ppp1r13b Plk3 Cox6c2 Pml Cnot3 Cnot2 Cnot1 Rnf34 Pip4k2b Cnot7 Pip4k2c Phf20 Cnot6 Pip4k2a Cnot4 Cnot9 Cnot8 Gls Sgk1 Cox6b1 Cox6b2 Rictor Prr5 G6pdx Casp2 Mapkap1 E2f7 E2f8 Prkaa1 Pip4p1 Prmt5 Prkaa2 Gpi Cdc25c Cox8a Cox8c Nuak1 Cox7b Cox7c Prkag3 Prkag1 Prkag2 Mdm4 Ywhaq Bnip3l Ywhah Mapkapk5 Ywhaz INTRA-GOLGI TRAFFIC%REACTOME%R-RNO-6811438.1 Intra-Golgi traffic Alpi Cog1 Cog2 Stx6 Rab33b Cog3 Ric1 Cyth2 Cog4 Cyth3 Stx5 Cyth4 Ykt6 Vti1a Vps45 Cyth1 Cog5 Cog6 Stx16 Cog7 Rgp1 Cog8 Napa Nsf Napb Napg Snap29 Bet1l Rab39a Rab36 Trip11 Akp3 Arf1 Alpp Alpg Gosr1 Gosr2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222377 RNA Polymerase III Transcription Initiation From Type 2 Promoter Gtf3c5 Bdp1 Tbp Polr3gl Crcp Polr3a Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr2h Polr3f Polr3g Polr2e Gtf3c2 Polr2f Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 96%10223437 EGFR interacts with phospholipase C-gamma Egfr Egf Ereg Tgfa Areg Plcg1 Hbegf Btc ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 96%10223269 Estrogen-dependent nuclear events downstream of ESR-membrane signaling Creb1 Mapk1 Cdkn1b Xpo1 Uhmk1 Akt3 Akt2 Akt1 Foxo3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-RNO-196780.1 Biotin transport and metabolism Slc5a6 Pc Hlcs Pcca Pccb Mccc1 Btd Mccc2 Acacb Acaca PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 Fgf16 Fgf17 Pik3ca Fgf18 Fgf19 Frs2 Pik3r1 Grb2 Klb Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 Gab1 PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair Txn Msra Pcmt1 Msrb1 Msrb3 Msrb2 SIGNALING BY NTRK2 (TRKB)%REACTOME%R-RNO-9006115.1 Signaling by NTRK2 (TRKB) Grb2 Fyn Dock3 Sos1 Bdnf Rac1 Frs2 Ntrk2 Plcg1 Ntf4 HOMOLOGY DIRECTED REPAIR%REACTOME%R-RNO-5693538.1 Homology Directed Repair Blm Wrn Dna2 Ppp4r2 Pias4 Ube2n Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Lig3 Sirt6 Rad51c Rad51b Chek1 Ube2v2 Rad9a Rad9b Bard1 Top3a Palb2 Firrm Ppp4c Lig1 Clspn Rad17 Fen1 Parp2 Xrcc3 Parp1 Rfc5 Slx1b Pold2 Xrcc2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Atm Rfc2 Atr Pold4 Tp53bp1 Pold3 Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 Abl1 Brcc3 ENSRNOG00000066901 Polq Herc2 Rnf168 ABRAXAS1 Sumo3 Rnf8 Rhno1 Slx4 Nsd2 Spidr Rad51 Rad50 Rad52 Ercc1 Ercc4 Babam1 Babam2 Topbp1 Rbbp8 Brca2 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Rad1 Polh Ccna1 Ccna2 Hist3h2ba Rps27a H2bc4 Hist1h4m H2bc1 Uba52 Pole3 Pole2 Pole4 Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Cdk2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-RNO-388841.1 Costimulation by the CD28 family Ywhag Suz12 Ddost Ppp2cb Eed Ppp2ca Gsk3b Cd274 Pdpk1 Os9 Pdcd1 Rnf5 Icoslg Sel1l Magt1 Rbbp4 Rbbp7 Mib2 Pdcd1lg2 Prkab2 Prkab1 Ppp2r5d Pak1 Ppp2r1b Ppp2r1a Pak2 Lyn Yes1 Src Grb2 Fyn Ppp2r5b Ppp2r5a Map3k8 RT1-Db2 Cd3g Ppp2r5e Cd247 RT1-Db1 Cd3e Cd3d Trav19 Map3k14 AC109737.1 Btla Cd4 RT1-Ha Lck RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da Grap2 H2ab2 H2ac4 ENSRNOG00000066901 Ctla4 Ccnd1 Kmt2a Kmt2c H2ac18 Csk Csnk2a2 Csnk2a1 Trib3 Hist1h2bq Wdr5 Ash2l Them4 Csnk2b Pik3ca H2aj Rac1 Ptpn6 Pak3 Psma4 Akt3 Psma3 H3-3b Akt2 Akt1 Hist3h2ba Psma6 Pik3r1 Pik3cb Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Pik3r2 Psmd12 Pik3r3 Psmd11 Vav1 Pik3cd Psmd14 Psmd13 Ptpn11 H2bc18 H2az2 Skp1 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Pik3r5 Pik3cg Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Cd28 Btrc Icos Psma7 Psmc5 Rictor Psmc2 Cd86 Psmc1 Cd80 Psmc4 Prr5 Psmc3 Mapkap1 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Mtor Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Pik3r6 Tmem258b Tusc3 Cdc42 Cdk4 Cul3 Ezh2 Mlst8 Erlec1 B3gnt3 Dad1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%10224799 Formation of xylulose-5-phosphate Sord Dcxr Akr1a1 Cryl1 Xylb TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 Phc1 Yaf2 Suz12 Eed Phc3 Tfdp2 Tfdp1 L3mbtl2 Ehmt1 Rbbp4 Rbbp7 Pcgf6 Rnf2 Chek1 Pcgf2 Bmi1 Mga Ring1 Cbx3 E2f6 Ezh2 Max Epc1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222851 Interleukin-17 signaling Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Uba52 Nfkb1 Fbxw11 Fos Btrc Vrk3 Rps6ka3 Rps6ka1 Rps6ka2 Tnip2 Nod2 Nod1 Map2k7 Map2k6 Ubb Dusp3 Ubc Dusp4 Ripk2 Dusp7 Dusp6 Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Cul1 Map2k3 Mapk1 Tab3 Tab2 Tab1 Chuk Mapk10 Mapk11 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222047 Aspartate and asparagine metabolism Aspg Nat8l Aspa Got2 Naalad2 Folh1 Got1 Slc25a12 Slc25a13 Gadl1 Asns IRON UPTAKE AND TRANSPORT%REACTOME%R-RNO-917937.1 Iron uptake and transport Slc40a1 Hmox2 Abcg2 Hmox1 Fbxl5 Nedd8 Atp6v0b Ireb2 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Rps27a Atp6v1d Hfe Tf Steap3 Steap4 Mcoln1 Tfrc Tfr2 Skp1 Fth1-ps5 Cp Heph Fth1 Uba52 Ftl1 Ubb Lcn2 Slc46a1 Ubc Slc11a2 Cybrd1 Ftmt Cul1 Aco1 Cand1 Slc22a17 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%10225391 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Nfe2l2 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222023 Glycogen synthesis Gys1 Gyg1 Pgm1 Gbe1 Ugp2 Ppp1r3c MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis Myog Myod1 Mef2d Boc Ctnna2 Bnip2 Spag9 Mef2a Mef2b Ctnnb1 Mef2c Myf6 Tcf4 Myf5 Tcf3 Ctnna1 Mapk12 Cdh15 Mapk14 Cdh2 Cdon Tcf12 Abl1 Cdc42 Mapk11 XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%10222317 Xenobiotics Ahrr Ahr Cyp2s1 Cyp3a9 Cyp2j16 Cyp3a18 Cyp2w1 Cyp2c66 Cyp2j3 Cyp2c24 Cyp2e1 Cyp2c11 Cyp1a1 Cyp2f2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp2a2 Cyp3a2 Cyp2a1 Cyp2a3 Arnt2 Arnt TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-RNO-425397.1 Transport of vitamins, nucleosides, and related molecules Slc29a4 Slc25a5 Slc25a4 Slc35b3 Slc33a1 Lcn9 Slc35b2 Slc5a6 Slc35d1 Lcn12 Slc35a1 Slc35c1 Apod Slc27a1 Arl2bp Slc27a4 Slc27a6 Slc35b4 Arl2 Slc35a3 Slc35a2 Slc35d2 Slc28a3 Slc28a2 Slc28a1 Vegp2 Vegp1 Slc29a3 Slc29a2 Slc29a1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222783 mTORC1-mediated signalling Lamtor2 Rptor RragB Fkbp1a Eif4ebp1 Mtor Rps6kb1 Rheb Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Eef2k Lamtor1 Rragc Rragd Rps6 Eif4e Mlst8 Lamtor3 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-RNO-9730414.1 MITF-M-regulated melanocyte development Lef1 Tnfsf11 Xpo1 Gsk3b Ube2i Crebbp Ctnnb1 Kitlg Qars1 Sin3a Lars1 Rars1 Kars1 Rps6ka1 Myo5a Sox10 Aimp2 Eprs1 Iars1 Tbx3 Mars1 Myrip Sytl2 Dars1 Hdac1 Tcf7 Tcf7l1 Rab27a Tcf7l2 Mark3 Akt3 Mapk3 Csf1 Ep300 Mapk1 Hint1 Mitf Sirt1 Kit Sumo1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224635 Positive epigenetic regulation of rRNA expression Sf3b1 Hist1h2ai Gsk3b Ddx21 Dek H2ac18 Baz1b Polr1c Myo1c Hist1h2bq Actg1 Kat2a H2aj H2ab2 Tbp Polr1b H3-3b Polr1a Hist3h2ba Polr1f Ep300 H2ac4 Polr1g Polr1e ENSRNOG00000068602 Polr1h Taf1d Mybbp1a Taf1a Taf1c Taf1b H2bc18 Polr2h Kat2b ENSRNOG00000066901 H2az2 Smarca5 Polr2e Polr2f H2bc4 Ercc6 Hist1h4m H2bc1 PLATELET HOMEOSTASIS%REACTOME%R-RNO-418346.1 Platelet homeostasis Slc8a1 Slc8a2 Ppp2cb Ppp2ca Slc8a3 Pde9a Calm3 Ppp2r5d Pde2a Pecam1 Nos1 Prkg2 Pde5a Itpr3 Itpr2 Itpr1 Pde10a Ptpn6 Ppp2r1b Atp2a1 Ppp2r1a Atp2a3 Pde1b Atp2a2 Pde1a Trpc7 Trpc3 Atp2b1 Apob Atp2b4 Atp2b3 Ptpn11 Sri Lrp8 Ppp2r5b Ppp2r5a Pde11a P2rx6 P2rx5 P2rx4 P2rx3 Fgr Ppp2r5e P2rx2 P2rx1 Nos2 Pafah2 Mapk14 P2rx7 Prkg1 Ptgir Nos3 Pla2g4a Irag1 MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling Prkaca Prkacb Rac1 Pak1 Pak3 Psma4 Pak2 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Kalrn Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Cdc14a Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk1 Ncoa3 Foxo1 Septin7 Mapk6 Mapk4 Cdc42ep2 Cdc42ep3 Hspb1 Cdc14b Etv4 Cdc42 Dnajb1 Mapkapk5 Ccnd3 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223241 Regulation of TP53 Expression and Degradation Rnf34 Ppp2cb Ppp2ca Phf20 Uba52 Pdpk1 Daxx Sgk1 Rictor Rffl Prr5 Chek2 Usp2 Mapkap1 Ubb Ubc Tp53 Usp7 Ccng1 Ppp2r1b Ppp2r1a Ccna1 Mtor Akt3 Ccna2 Akt2 Akt1 Cdk2 Atm Cdk1 Rps27a Mdm4 Mlst8 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%10225069 MET interacts with TNS proteins Hgf Itgb1 Met Tns4 Tns3 LIPOPROTEIN METABOLISM%REACTOME%R-RNO-174824.1 Lipoprotein metabolism Lipa Lipc Bmp1 Zdhhc8 Furin Pcsk5 Prkaca Prkacb Pcsk6 Apoc1 Apoc4 Lipg Pltp Lcat Alb Nceh1 Apobr Npc2 Npc1 Ldlr Mttp Lmf1 Apoc2 A2m Apoa1 Lmf2 Apoa5 Apoc3 Apoa2 Sar1b Rps27a Apoe Apoa4 P4hb Apob Nr1h3 Pcsk9 Nr1h2 Lpl Gpihbp1 Ldlrap1 Soat2 Soat1 Uba52 Scarb1 Vldlr Abca1 Angptl8 Cubn Ubb Ap2m1 Ubc Angptl4 Clta Angptl3 Cltc Mylip Amn Hdlbp Ap2s1 Ap2a2 Ap2a1 Ap2b1 AGGREPHAGY%REACTOME%R-RNO-9646399.1 Aggrephagy Dync1h1 Ube2n Uba52 Dync1i2 Dync1i1 Pcnt Dync1li2 Prkn Dync1li1 Rps27a Arl13b Dynll1 Dynll2 Ubb Park7 Ubc Cftr FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-9617828.1 FOXO-mediated transcription of cell cycle genes Foxo1 Foxg1 Foxo4 Smad2 Smad3 Smad4 Foxo3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism Ppcs Dcakd Ppcdc Coasy Pank4 Aasdhppt Fasn Slc25a16 Slc25a42 Slc5a6 Vnn1 Pank3 Pank2 Pank1 INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling Ppp2cb Ppp2ca Nedd4 Prkcd Hspa1b Ube2l6 Hspa1a Ybx1 Ppp2r1b Ppp2r1a Mapk3 Camk2g Tyk2 Camk2d Camk2b Ikbkb Camk2a Ikbkg Ppp2r5a Ube2n Map2k6 Kpnb1 Tp53 Kpna1 Ifng Ifngr2 Ifngr1 Raf1 Jak2 Ptpn1 Irf3 Mavs Rig1 Adar Fnta Usp18 Fntb Pias1 Chuk Ifi44 Ifi44l Uba7 Socs1 Sumo1 Stat3 Furin Stat1 Plcg1 Actg1 Ptpn6 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Ifnb1 Rnasel Ifna4 Ifna1 Ifna1l1 Ifna4l1 Rps27a Irf9 Ptpn11 Sfn Dnajc3 Eif2ak2 Sphk1 Fancl Fancm Pim1 Uba52 Fanca Fancb Fancc Mapt Fance Fancf Fancg Hspa8 Nck1 Gbp5 Pde12 Prkra Ilf2 Actb Dus2 Ilf3 Flnb Tarbp2 Snca Dhx9 Ppm1b Mx2 Arih1 Pggt1b Trim25 Ubb Ptpn2 Hspa1l Ubc Gbp2 Gbp1 Ube2e1 Gbp3 Faap100 Npm1 Casp1 Oasl Hspa2 Faap24 Isg15 Fkbp5 Faap20 Socs3 Cdk1 Becn1 Mapk1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) Ywhag Psmb6 Psmb1 Ccnd1 Psmb3 Psmb2 Uba52 Cd274 Psma7 Psmc5 Psmc2 Psmc1 Csnk2a2 Psmc4 Psmc3 Csnk2a1 Ubb Ubc Psmb6l1 Csnk2b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Psma6 Spop Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdk4 Cul3 Psmb5 Psmb4 Psmb7 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) Uba52 Mvb12a Mvb12b Vps37a Vps37b Vps37c Vps37d Vps36 Vps25 Vps28 Tsg101 Ubb Snf8 Ubc Ubap1 Hgs Chmp2b Chmp3 Chmp7 Chmp6 Chmp5 Rps27a Stam2 Vps4a Chmp4c Chmp4bl1 Vps4b Stam Chmp2a PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222095 Phenylalanine and tyrosine metabolism Hpd Fah Asrgl1 Pcbd1 Qdpr Kyat1 Hgd Tat Pah Il4i1 Gstz1 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10225433 Mitochondrial protein degradation Cox5a Pheta2 Acad8 Cox5b Prkaca Pmpca Ech1 Twnk Shmt2 Ssbp1 Oxsm Mrps2 Htra2 Mt-atp6 Tfam Aldh2 Lonp1 Aldh1b1 Atp5f1c Clpp Iars2 Atp5pd Star Clpx Suclg2 Bdh1 Oxct1 Atp5pf Hmgcs2 Atp5mg Atp5f1b Cs Atp5f1a Atp5po Hspd1 Acot1 Acot2 Fh Acot5 App Acot3 Pdk1 Aco2 Ldhd Pdhb Mrpl32 Uqcrq Idh3a Ndufv1 Ndufv3 Mrps10 Slc25a5 Hadh Ndufs1 Ndufa13 Dbt Eci1 Ndufs3 Glud1 Mrpl12 Uqcrc2 Ogdh Acadsb Pccb Me2 Arg2 Dld Nadk2 Mdh2 Hspa9 Idh2 Mt-co1 Afg3l2 Hsd17b10 Alas1 Acat1 Fech Aldh18a1 Spg7 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-RNO-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands Hebp1 Fpr1 Ccl6 Fpr2l3 Fpr2 App Fpr2l1 Ccl9 Anxa1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224187 Tandem pore domain potassium channels Kcnk4 Kcnk2 Kcnk1 Kcnk13 Kcnk10 Kcnk16 Kcnk9 Kcnk7 Kcnk18 Kcnk6 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 96%10225457 Regulation of endogenous retroelements Hist1h2ai Cbx5 Znf431l2 Tasor Zfp324 H2ac18 LOC120095871 Setdb1 ENSRNOG00000065205 Trim28 Pphln1 Znf382 Znf624l Zfp719 Zfp867 Hist1h2bq ENSRNOG00000070049 Mphosph8 H2aj Zfp808l3 Atf7ip H2ab2 Zfp758 H3-3b Rex2l4 Hist3h2ba Zfp317 H2ac4 ENSRNOG00000068602 Zfp52 Zfp950l5 Zfp964 Znf354a H2bc18 Morc2 ENSRNOG00000066901 H2az2 LOC102546572 H2bc4 Hist1h4m H2bc1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%10225093 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Cbfb Crebbp Runx1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases Mmp16 Mmp17 Mmp8 Furin Try10 Prss2l1 Ctrb1 Mmp10 Plg Klkb1 Ctsk Try5 LOC102554637 Mmp7 Timp1 Mmp2 Mmp3 Timp2 Prss2 Prss3 Mmp9 Elane Mmp1b Tpsb2 Prss1 Spock3 Mmp24 Mmp25 Col18a1 Ctsg ENSRNOG00000069479 Mmp11 Mmp13 Cma1 Mmp14 Mmp15 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225475 SLC15A4:TASL-dependent IRF5 activation Ikbkg Tasl Chuk Irf5 Ikbkb Slc15a4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-RNO-202433.1 Generation of second messenger molecules Plcg1 Nck1 Zap70 RT1-Db2 Cd3g Cd247 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Itk RT1-Ba RT1-Bb Plcg2 ENSRNOG00000065955 Trbv16 RT1-Da Grap2 Pak1 Pak3 Pak2 Cd101 Fyb1 Lat Lcp2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 96%10222021 Biological oxidations Tpst1 Mtr Tpst2 Sult2b1 Sult1a1 Sult1c2 Sult1b1 Bpnt2 Sult6b1 Sult4a1 Sult2a2 Bpnt1 Ugt1a2 Ugt1a1 Ugt1a3 Sult2a1 Ugt1a5 Sult2a6 Abhd14b Podxl2 Ugt2b1 Ugt2b7 AC114845.1 Ugt2b34l1 Smox Ugt2b Ugt2b17 Ugt2b37 Arnt2 Ugt2b15 Arnt Ahrr Ahr Ugt1a6 Ugt1a7 Tbxas1 Ugt1a8 Nat1 Nat2 Ptgis Nat3 Ugt2a1 Ptgs1 Ugt2a3 Ces2h Acy1a Ugt3a1 Hsp90ab1 Cyb5b Acss2 Uxs1 Ugp2 Ugdh Cyp39a1 Cyp2s1 Ncoa2 Cyp8b1 Cyp7b1 Nr1h4 Cyp46a1 Cyp27a1 Cyp7a1 Cyp2u1 Aldh1a1 Dpep1 Dpep2 Cyp11a1 Fdx2 Fdxr Cyp26b1 Rxra Cyp26a1 Cyp24a1 Cyp27b1 Adh4 Fdx1 Adh1 Slc35d1 Ptges3 Cyp2j16 Adh7 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp26c1 Cyp4b1 Cyp2a2 Cyp2a1 Cyb5r3 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 Gstz1 Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Chac1 Chac2 Gstm7 Gstm5 Gstk1 Ggct Gstm1 Gclc Gstm2 Mgst3 Gsto2 Esd Cndp2 Mgst2 Mgst1 Gclm Ggt1 Ggt5 Ggt7 Ggt6 Hpgds Gss Gstp1 Pomc Gstt2 Akr1a1 Gstt1 Oplah Cyp1b1 Cyp4v2 Maoa Cyp21 Cyp11b3 Maob Ces1d Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Cyp2w1 Cyp2c24 Gstm4 Aldh2 Mat1a Aldh1b1 Adh6 Adh5 Cmbl Ephx1 Acy3 Aldh3a1 Fmo1 Aadac Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Akr7a3 Akr7a2 Cyp11b1 Cyp11b2 Cyp19a1 Abhd10 Acss1 Mtarc2 Bphl Cyp3a9 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp3a2 Aoc1 As3mt Ahcy Comt Mtrr Gsto1 Tpmt Mat2a Sult1e1 Mat2b FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization ENSRNOG00000070986 Plcg1 Calm3 Shc1 Lyn Vav3 Grb2 Vav1 Vav2 Sos1 ENSRNOG00000069193 AABR07065813.1 Lcp2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Txk Igkvl13 Ppp3ca AABR07065812.2 Ppp3cb Itk ENSRNOG00000063707 Nfatc1 Plcg2 Nfatc3 ENSRNOG00000067679 Nfatc2 ENSRNOG00000070832 Ppp3r1 ENSRNOG00000064041 ENSRNOG00000064481 Grap2 ENSRNOG00000065690 ENSRNOG00000064085 Tec ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Btk Lat SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223789 Sodium-coupled phosphate cotransporters Slc20a2 Slc20a1 Slc34a1 Slc34a3 Slc17a1 Slc34a2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-RNO-196854.1 Metabolism of vitamins and cofactors Mtr Mmachc Slc22a13 Nfs1 Naxd Nmnat3 Nmnat2 Qprt Akr1c18 Mthfd1 Abcc1 Akr1c12l1 Mthfd2 Akr1c19 Folr2 Gphn Pank4 Mocos Akr1c21 Gsto2 Calm3 Shmt2 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Prkg2 Akr1c9 Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Lrp1 Sdc4 Cyb5a Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Gpc6 Clps Pnlip Akr1b10 Rbp4 Apom Rbp2 Rbp1 Sdc1 Lrat Gch1 Idh1 Pdss2 Coq8a Pdss1 Coq8b Coq2 Pts Coq3 Gchfr Coq4 Coq5 Coq6 Hpdl Coq7 Spr Coq9 Stard7 Aco1 Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Akt1 Hsp90aa1 Nampt Shmt1 Ldlrap1 Pdxk Naxe Slc52a2 Ubiad1 Slc52a3 Vkorc1 Lrpl1 Rdh11 Ttpa Mccc1 Vkorc1l1 Btd Mccc2 Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Bst1 Vnn1 Cblif Tcn2 Fpgs Mmut Mthfs Cubn Mthfr Slc25a32 Slc46a1 Pank3 Slc23a1 Pank2 Mthfd1l Pank1 Slc23a2 Ppcs Naprt Dcakd Mmadhc Ppcdc Pcca Coasy Rfk Agrn Pccb Acp5 Aox1 Slc2a1 Slc2a3 Nadk2 Nudt12 Mthfd2l Amn Nmrk1 Mocs3 Slc25a16 Pc Hlcs Nos3 Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Mtrr Flad1 Gsto1 Mmab Nt5e Rnls Enpp1 Mocs1 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling Lipc Furin Pcsk5 Pcsk6 Lipg Pltp Lcat Angptl8 Alb Angptl4 Angptl3 Lmf1 Mttp Apoc2 Lmf2 Apoa1 Apoc3 Apoa5 Apoa2 Apoe Apoa4 P4hb Apob Lpl Gpihbp1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10223297 CREB phosphorylation Creb1 Rps6ka1 Rps6ka2 Mapkapk2 Atf1 Rps6ka5 Rps6ka3 PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding Csnk2b Sphk1 Rgs7 Pdcl Tcp1 Cct6b Cct7 Cct6a Gnb2 Gnb1 Gnb4 Cct8 Gnb3 Cct5 Gnb5 Cct4 Csnk2a2 Csnk2a1 Cct3 Cct2 Rgs9 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Utp18 Wdr43 Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Rpl35al8 Ddx49 Wdr36 Rpl22l1 Rplp0 Ddx47 Rplp1 Rpl13a Rpl35al2 Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Mphosph6 Nol9 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rpl10a Exosc9 Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Rps2 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Csnk1d Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Las1l Rps27 Ltv1 Rpsa Rpl35 Rps10 Fcf1 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rrp9 Rps8 Rpl6 Rps5 Pwp2 Rpl7 Rps26-ps13 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rpl24 Rpl26 Rps3 Imp4 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rpp25 Rps29 Rpl12-ps1 Ubc Rps20 Ncl Rps21 Rpl22 Rps23 Xrn2 Rps24 Rpl23 Snu13 Wdr75 Senp3 Fau Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Pdcd11 Pno1 Rpl27a Rpl31l15 Utp20 Nop14 Pelp1 Rcl1 Utp25 Tbl3 Nol11 Rps6 Rpp40 LOC100910714 LOC102551819 Wdr3 Bud23 Dcaf13 Csnk1e Utp15 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation Mapk1 Grb2 Irs2 Shc1 Ins2 Insr Sos1 Irs1 Grb10 Mapk3 Ins1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 96%10222335 mRNA Capping Polr2j Ncbp2 Ncbp1 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Cdk7 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Rngtt Polr2c Rnmt Polr2a Polr2b Mnat1 Polr2g Polr2h Polr2e Polr2f Polr2i NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival Uba52 Nfkb1 Irak1 Ngf Nfkbia Sqstm1 Rela Rps27a Ngfr Ikbkb Ubb Ubc Traf6 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223759 Golgi Associated Vesicle Biogenesis Ttgn1 Igf2r Ocrl Napa Bloc1s3 Bloc1s4 Bloc1s6 ENSRNOG00000062839 Tpd52 Snapin Arf1 Tbc1d8b Golgb1 Vamp2 Tpd52l1 Tfrc Dnajc6 Dtnbp1 Ap4b1 Fth1-ps5 Pik3c2a Ap1b1 Ap1m2 Vamp7 Bloc1s1 Ap1m1 Vamp8 Fth1 Ap1s3 Ap1s2 Arrb1 Txndc5 Necap1 Ap1g1 Hspa8 Ap4e1 Hip1r Cpd Snx2 Snx9 Picalm Snx5 Pum1 Dnm2 Ftl1 Gak Yipf6 Clta Sort1 Ap3b1 Cltc Sh3d19 Acbd3 Sh3gl2 Rab5c S PHASE%REACTOME DATABASE ID RELEASE 96%10221915 S Phase Gins2 Gins1 Gins4 Gins3 Wapl Esco1 Esco2 Pds5b Pds5a Cdca5 Dna2 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Ccnh Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Smc3 Cdc25b Ccnd1 Stag2 Stag1 Cdk7 Mnat1 Smc1a Psma4 Ccna1 Akt3 Psma3 Akt2 Ccna2 Ube2s Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Cdc25a Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Gmnn Psmb5 Ptk6 Psmb4 Psmb7 Cdc6 Psmb6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Cks1b Cables1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Wee1 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Cdkn1b Psmd7 Pole Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 Cdk4 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-RNO-8951671.1 RUNX3 regulates YAP1-mediated transcription Runx3 Tead2 Tead4 Yap1 Tead3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Ogn St3gal6 St3gal4 St3gal2 St3gal3 St3gal1 Slc35d2 B3gnt7 B3gnt2 Kera B4galt4 B4galt5 B4galt6 Prelp Fmod B3gnt3 B4gat1 Lum SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 96%10224909 Signaling by MST1 Hpn Spint2 Spint1 Mst1 Mst1r SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 96%10223379 Signaling by SCF-KIT Grb7 Stat3 Stat1 Ptpru Grap Kitlg Fer Prkca Sh2b2 Fes Chek1 Grb10 Lck Stat5a Stat5b Grap2 Tec Jak2 Pik3ca Mmp9 Rac1 Ptpn6 Gab2 Lyn Yes1 Src Pik3r1 Cbl Nras Grb2 Pik3r2 Fyn Pik3r3 Kras Vav1 Sos1 Hras Ptpn11 Cma1 Kit DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10222939 Downregulation of TGF-beta receptor signaling Mtmr4 Uba52 Smad2 Tgfbr1 Smad3 Tgfbr2 Smad7 Strap Stub1 Bambi Rps27a Ubb Ubc Smurf2 Tgfb1 PYROPTOSIS%REACTOME DATABASE ID RELEASE 96%10222541 Pyroptosis Casp1 Gsdme Elane Il1a Chmp2b Gsdmd Il1b Cycsl2 Chmp3 Hmgb1l2 Chmp7 Hmgb1l1 Chmp6 Bax Bak1 Il18 Chmp4c Chmp4bl1 Casp3 Gzmb Cycs Hmgb1-ps34 Chmp2a HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223963 Highly calcium permeable nicotinic acetylcholine receptors Chrna6 Chrna5 Chrnb4 Chrna4 Chrnb3 Chrnb2 Chrna3 Chrna2 Chrna1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis Mvd Srd5a3 Dpm2 Dpm1 Dpm3 Gmppa Pmm2 Mpi Pmm1 Nagk Gnpnat1 Amdhd2 Uap1 St8sia6 Gfpt1 St8sia4 Gfpt2 Pgm3 St8sia5 Renbp Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 Dhdds St3gal6 Nudt14 St6galnac2 Alg5 St3gal4 Dolpp1 St3gal5 Fuom St3gal2 Gmds St3gal3 Slc35a1 Dolk Fcsk St3gal1 Dhrsx Nanp St6gal1 Nus1 Glb1 Fpgt St6gal2 Gfus Slc35c1 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-RNO-5173214.1 O-glycosylation of TSR domain-containing proteins Adamts4 Adamtsl3 Adamtsl4 Adamts1 Adamtsl5 Adamts3 Adamts2 Adamts20 Adamts9 Thsd7b Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Thsd4 Cfp Spon2 Spon1 Sspo B3glct Thbs1 Sema5a Sema5b Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Adamts19 Adamts10 Sbspon Adamts12 Thsd7a Adamts5 Adamtsl1 Adamtsl2 MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis Fignl1 Rad51 Dmc1 Firrm AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-RNO-174084.1 Autodegradation of Cdh1 by Cdh1:APC C Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdc16 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225137 SLIT2:ROBO1 increases RHOA activity Myo9b Rhoa ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%10222817 Activation of C3 and C5 C2 C4 C3 C5 C4b ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224091 Activation of G protein gated Potassium channels Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222957 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdc16 Cdk1 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity Hgs Hgf Ptpn1 Uba52 Met Lrig1 Cbl Stam2 Rps27a Grb2 Eps15 Sh3gl3 Sh3kbp1 Stam Sh3gl2 Sh3gl1 Ptpn2 Ubb Ubc Usp8 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223777 Small interfering RNA (siRNA) biogenesis Ago3 Ago2 Ago1 Dicer1 Tarbp2 Tsnax Tsn Prkra Ago4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-RNO-2243919.1 Crosslinking of collagen fibrils Pxdn Loxl2 Bmp1 Loxl1 Lox Pcolce Tll2 Loxl4 Tll1 Loxl3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%10222353 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Snrpg Ncbp2 Snrpb Ncbp1 Zfp473 Snrpepl2 Lsm10 Lsm11 Slbp Snrpf Snrpd3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 96%10222923 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Tgif1 Ccnc Tgif2 Atp1b4 Uba52 Furin Tfdp2 Tfdp1 Ube2d1 Trim33 Rbl1 Ccnk Men1 Ccnt2 Cdk9 Ube2d3 Ubb Hdac1 Ubc Rnf111 E2f4 E2f5 Parp1 Ppm1a Smad2 Ncor2 Smad3 Smad4 Mapk3 Smad7 Ski Mapk1 Rps27a Wwtr1 Sp1 Usp9x Skil Smurf2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 96%10223345 G beta:gamma signalling through PI3Kgamma Gng7 Pik3r5 Pik3cg Gng8 Gngt1 Pdpk1 Akt3 Akt2 Gnb2 Akt1 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Pik3r6 Gng3 Gng5 Gng4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 96%10224137 Antigen processing-Cross presentation Psme2 Psme1 Psmb9 Psmb10 Psmb8 Cyba RT1-M6-2 Vamp3 Cybb B2m Lnpep RT1-M10-ps1 RT1-M10-ps5 Snap23 Cd207 Mrc2 Mrc1 Psma4 RT1-N3 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 RT1-M1-2 Psmb4 Psmb7 Psmb6 Psmb1 RT1-M1-5 Psmb3 Vamp8 Psmb2 Rt1-ec3 Cd36 Psma7 Ncf1 Ncf2 Ncf4 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 AABR07044308.1 Pdia3 Fcgr1a Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 RT1-M5 RT1-M2 Itgav INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%10222523 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Prim2 Prim1 Ppp2cb Rb1 Ppp2r3b Ppp2ca Ppp2r1b Ppp2r1a Pola2 Pola1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-RNO-8984722.1 Interleukin-35 Signalling Il12a Canx Jak2 Tyk2 Stat3 Stat1 Il12rb2 Il6st Ebi3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 96%10222667 Peptide chain elongation Eef2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%10222125 tRNA Aminoacylation Ppa1 Ppa2 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%10223447 Synthesis of PC Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Pctp Chat Cept1 Chka Chkb Csnk2a2 Phospho1 Csnk2a1 Lpin3 Lpin2 Lpcat1 Mfsd2a Pcyt1b Pcyt1a Abhd3 Pemt Csnk2b Chpt1 Stard10 Stard7 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%10222259 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-RNO-2142700.1 Biosynthesis of Lipoxins (LX) Alox12 Alox5ap Hpgd Alox5 Ltc4s ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface Slc11a1 Atp7a Atox1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 96%10224803 UCH proteinases Ino80 Uchl3 Uchl5 Ino80e Ino80d Ino80c Ino80b H2ac18 Mbd5 Mbd6 Uchl1 Nedd8 Actg1 Kdm1b Ruvbl1 Psma4 Psma3 Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2ac25 Senp8 Psmb5 Psmb4 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Asxl1 Hcfc1 Asxl2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Mcrs1 Bard1 Ubb Ogt Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Nfrkb Psmd2 Foxk2 Foxk1 Psmd1 Adrm1 H2ac4 Tfpt Bap1 Actl6a Actr5 Yy1 Actr8 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-RNO-379716.1 Cytosolic tRNA aminoacylation Ppa1 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%10224595 Depolymerization of the Nuclear Lamina Lmna Ccnb1 Lmnb1 Ctdnep1 Cnep1r1 Lpin3 Prkcb Lpin2 Cdk1 Emd Prkca SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%10225429 Specification of the neural plate border Tfap2c Tfap2a Tfap2b CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%10222479 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde Camk4 Calm3 Camkk1 Camkk2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction Stat6 Grb7 Stat3 Stat1 Plcg1 Nck1 Rasa1 Pdgfa Pdgfb Stat5a Stat5b Bcar1 Pik3ca Nck2 Crkl Pdgfrb Src Pdgfra Rapgef1 Pik3r1 Pik3cb Nras Grb2 Pik3r2 Kras Sos1 Hras Ptpn11 Crk ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%10223571 Enzymatic degradation of dopamine by COMT Maoa Tomt Comt RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225085 RUNX1 regulates estrogen receptor mediated transcription Cbfb Esr1 Runx1 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 96%10221991 Regulation of TP53 Activity Zfp385a Ppp2cb Ppp2ca Pdpk1 Ttc5 Pou4f1 Rbbp4 Rbbp7 Pou4f2 Prkab2 Prkab1 Usp2 Cdk5r1 Brpf3 Usp7 Ppp2r1b Ppp2r1a Cdk5 Tp53rkb Tp53rka Blm Wrn Dna2 Mre11 Kat5 Nbn Hus1 Atrip Rffl Chek1 Chek2 Rad9a Rad9b Banp Bard1 Tpx2 Top3a Tp63 Map2k6 Tp53 Rad17 Hdac2 Rfc5 Ccng1 Mapk14 Rfc3 Rfc4 Kmt5a Atm Rfc2 Atr Exo1 Rmi2 Rmi1 Brip1 Mapk11 Tp73 Jmy Rhno1 Dyrk2 Rad50 Ehmt1 Daxx Ing2 Ing5 Csnk2a2 Brd1 Topbp1 Rbbp8 Csnk2a1 Ssrp1 Brca1 Brd7 Rad1 Hdac1 Smyd2 L3mbtl1 Csnk2b Tp53bp2 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Brpf1 Ccna1 Taf12 Akt3 Tbp Akt2 Taf4b Kat6a Ccna2 Akt1 Taf7l-ps1 Ep300 Noc2l Meaf6 Chd3 Taf8 Rps27a Chd4 Taf7 Taf6 Taf5 Hipk1 Taf4 Taf2 Taf1 Mta2 Ppp1r13l Mbd3 Ppp1r13b Plk3 Gatad2a Gatad2b Pml Rnf34 Pip4k2b Uba52 Pip4k2c Phf20 Pip4k2a Sgk1 Aurka Aurkb Rictor Prr5 Rpa1 Rpa2 Mapkap1 Ubb Rpa3 Ubc Prkaa1 Pip4p1 Prmt5 Prkaa2 Mtor Cdk2 Cdk1 Nuak1 Prkag3 Prkag1 Prkag2 Mdm4 Stk11 Mapkapk5 Mlst8 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling Pdpk1 Prkcd Uba3 Cdc34 Calm3 Ube2d2 Il1b Psma4 Psma3 Psma6 Src Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Traf6 Psmb7 Psmb6 Ikbkg Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Relb Uba52 Nfkb2 Nfkb1 Ube2d1 Fbxw11 Btrc Psma7 Rela Psmc5 Ube2m Psmc2 Psmc1 Psmc4 Psmc3 Map3k14 Ppp3ca Ppp3cb Nfatc1 Plcg2 Ubb Nfatc3 Pycard Malt1 Nfatc2 Ubc Ppp3r1 Bcl10 Psmb6l1 Psmd7 Casp8 Clec7a Psmd6 Card9 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Nfkbia Tab3 Tab2 Tab1 Chuk MMR%REACTOME DATABASE ID RELEASE 96%10224651 MMR Pold2 Pold1 Mlh1 Msh6 Pcna Msh2 Pms2 Pold4 Pold3 Exo1 Rpa1 Rpa2 Rpa3 Lig1 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 96%10224491 Processing and activation of SUMO Sumo3 Senp1 Ube2i Uba2 Senp5 Rwdd2b Senp5l1 Sae1 Sumo2 Senp2 Sumo1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%10222451 Transport of the SLBP independent Mature mRNA Nup133 Nup210 Ncbp2 Nup155 Ncbp1 Nup153 Nup93 Nup50 Alyref Nxf1 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Eif4e Ranbp2 Nup214 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 96%10224099 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10223565 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Wwox Npm1 Tfap2c Esr1 Tfap2a Ube2i Tfap2b Myc Crebbp Kctd1 Dek Kdm5b Atad2 Lhb Tfap2e Cga Ep300 Cited4 Cited1 Cited2 Yeats4 Sumo1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-RNO-159236.1 Transport of Mature mRNA derived from an Intron-Containing Transcript Nup133 Slu7 Nup210 Nup155 Nup153 Thoc2 Thoc3 Thoc5 Thoc6 Thoc7 Magohb Chtop Poldip3 Casc3 Nxt1 Nxf5 Nxf7 Srsf1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Ncbp2 Ncbp1 U2af1 U2af1l4 Rnps1 Gle1 Fyttd1 Cdc40 Ddx39a Nup93 Nup50 Alyref Nxf1 Nup35 Magoh Ddx39b Nup54 Nup98 Upf3b Sarnp Nup58 Nup37 Pom121 Nup205 Nup107 Dhx38 Sec13 Nup188 Tpr Eif4a3 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Rbm8a Aaas Srsf11 Ranbp2 Nup214 Srrm1 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism Plaat5 Agk Ddhd2 Agpat4 Agpat1 Pcyt2 Tafazzin Cept1 Lclat1 Etnk2 Etnk1 Etnppl Chka Gnpat Chkb Rab14 Selenoi Phospho1 Sacm1l Pi4ka Lpin3 Pi4kb Lpin2 Pik3c2g Tpte2 Mtmr1 Arf3 Arf1 Plb1 Pten Chat Pip5k1b Dgat2l6 Dgat2 Dgat1 Pnpla3 Mtmr14 Pld1 Mtmr3 Stard7 Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Hadha Hadhb Agpat2 Alpi Inpp5e Cpne1 Pla2g4f Pla2g2d Cpne3 Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Csnk2a2 Ocrl Inpp5j Pla2g4d Plbd1 Pla2r1 Csnk2a1 Pla2g12a Mboat7 Synj1 Pla2g10 Plaat3 Pld2 Pla2g5 Csnk2b Inpp5d Pik3ca Pip5k1c Pik3r1 Sbf1 Pik3cb Synj2 Pik3r2 Pik3r3 Inppl1 Pik3cd Ptpn13 Ptdss1 Ptdss2 Pla2g15 Inpp5f Pla2g4b Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 Plekha8 Pik3r5 Fig4 Agpat3 Slc44a3 Pik3cg Vac14 Slc44a4 Mtmr12 Slc44a5 Pi4k2a Slc44a1 Pip4k2b Mtmr4 Pip4k2c Pik3r4 Slc44a2 Pip4k2a Rab5a Pctp Rab4a Pip5k1a Awat2 Pnpla2 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pla2g6 Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Stard10 Plekha6 Plekha5 Gpd1l Pip4p1 Plekha4 Abhd4 Plekha3 Osbpl10 Plekha2 Miga2 Plekha1 Tnfaip8l2 Miga1 Gpat2 Tnfaip8l3 Gpd1 Tnfaip8l1 Pgp Mboat1 Rufy1 Mboat2 Pitpnb Gpam Gpd2 Osbpl5 Inpp5k Pld6 Pik3c2b Pla1a Bmx Mgll Osbpl8 Pla2g4a Tnfaip8 Cpne6 Mtmr7 Cpne7 Mtmr6 Liph Mtmr9 Lipi Cds2 Pik3r6 Gde1 Acp6 Gpat4 Pnpla6 Gpat3 Enpp6 Lpcat3 Lpcat2 Tmem86b Pnpla8 Plaat1 PROTEIN HYDROXYLATION%REACTOME%R-RNO-9629569.1 Protein hydroxylation Etf1 Rpl8 Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Rpl27a Rps6 Jmjd6 Riox2 Rps23 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs Rab21 Chml Rab9a Rab9b Dennd2a Rab1A Dennd2c Ric1 Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Rgp1 Ankrd27 Dennd3 Rab3il1 Madd Akt3 Akt2 Akt1 Sbf2 Sbf1 Rab31 Rab35 Rab38 Rab3gap2 Rab3gap1 Dennd1a Rab1b Ulk1 Dennd1b Trappc2l Dennd1c Rin3 Rin1 Rin2 Mon1b Dennd6a Mon1a Dennd6b Rab5a Trappc10 Hps1 Ccz1 Hps4 Trappc12 Trappc11 Trappc13 Rab3a Rinl Gapvd1 Als2cl Gdi1 Rabgef1 Gdi2 Chm Rab7a Rab7b Dennd4c Dennd4a Dennd4b Ywhae Rab27a Rab39a Rab27b Trappc6b Trappc6a Trappc9 Trappc8 Trappc5 Trappc4 Trappc3 Dennd5a Trappc2 Trappc1 Rab6b Rab6a Rab5c Rab5b Dennd5b Als2 Rab3ip INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Ube2s Cdc16 Anapc15 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Anapc7 Cdc20 Ube2e1 HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism Hyal5 Chp1 Hyal4 Slc17a5 Hyal3 Cemip Hyal1 Gusb Chp1l1 Hyal2 Cd44 Has1 Has2 Has3 Slc9a1 Abcc5 Hexa Hexb PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%10222559 Platelet activation, signaling and aggregation Aldoa Pdpk1 Prkcq Rasgrp1 Tln1 Fn1 Pdgfa Pdgfb Alb Ptk2 Mapk3 Apoa1 Grb2 Fyn Rap1a Rap1b Sos1 App Apbb1ip Cd36 Hgf Vcl Bcar1 Ptpn1 Rapgef4 Tuba4a Rapgef3 Mapk14 Rasgrp2 Prkcb Tbxa2r Ppbp Lat Tgfb1 Tgfb2 Tgfb3 Fgb Fga Fgg Pcdh7 Itga2b Plg Csk Egf Serping1 Itgb3 Clu Timp1 Rac1 Akt1 A2m Tf F2 Phactr2 Stxbp2 Stxbp3 Plcg2 Vti1b Chid1 Abcc4 Prkch Prkce Cfd Pf4 A1bg Gp6 Gp5 Rab27b Gp9 Serpine1 Islr Pcyox1l Hrg Mgll Mapk1 Pla2g4a P2ry12 Lhfpl2 Gng10-ps1 Pik3r6 Gas6 Sytl4 Ly6g6f Ahsg Crk Spp2 Stx4 F2rl2 Serpina3n F2rl3 Adra2b Timp3 Fam3c Mpig6b Prkcg Prkcd Dgka Serpinf2 Gnai2 Dgkb Gnai1 Abhd6 Prkca Dgkd Gnai3 Dgke Dgkg Gna11 F13a1 Anxa5 Gna14 Calm3 Qsox1 Gng3 Brpf3 Vegfa Lgals3bp Vegfd Dgkh Gng5 Vegfc Dgki Gng4 Dgkk Vegfb Gnaq Lamp2 Dgkq Gng7 Gng8 Gngt1 Dgkz Itpr3 Gnat3 Itpr2 Itpr1 F2r Wdr1 Lyn Gnb2 Daglb Gnb1 Maged2 Src Rhoa Gnb4 Trpc7 Kng1 Gnb3 Trpc3 Gnb5 Endod1 Gng11 Serpina4 Dagla F8 Actn2 Lcp2 Habp4 Cdc37l1 Serpina1 Arrb2 Arrb1 Tagln2 Adra2a Itih4 Itih3 Adra2c Pros1 Aamp Cd109 Nhlrc2 Fermt3 Lck Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Igf2 Igf1 Sparc Apoh Raf1 Gtpbp2 Orm1 Ecm1 Rhog Ola1 Rhob Gp1bb Ctsw Rac2 Gp1ba Actn4 Psap Flna Tmsb4x Cd63 Tor4a Clec1b P2ry1 Tmx3 Fcer1g Pdpn Scg3 Selp Cyrib Abhd12 Sccpdh Srgn Pecam1 Actg1 Actn1 Aplp2 Cyb5r1 Mmrn1 Cd9 Pik3ca Plek Shc1 Sod1 Ptpn6 Pik3r1 Pik3cb Vav3 Pik3r2 Pik3r3 Vav1 Vav2 Ptpn11 Pik3r5 Pik3cg Gna13 Syk Cdc42 Ywhaz SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%10223607 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ffar4 Dpp4 Gpr119 Lep Gcg Ffar1 Grp CILIUM ASSEMBLY%REACTOME%R-RNO-5617833.1 Cilium Assembly Ywhag Actr1a Dctn1 Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Rpgrip1l Septin2 Kif24 Ttbk2 Ift140 Tctn3 Fbf1 Tctn1 Kif3a Akap9 Tctn2 Iqcb1 B9d1 Cep89 Mks1 Ahi1 Ift52 Nphp4 Ttc21b Cep83 Ift57 Nphp1 Ift122 Ofd1 Sclt1 Tmem216 Wdr35 Prkar2b Dync2h1 Ppp2r1a Ift172 Wdr19 Arf4 Cep97 Csnk1d Ccp110 Gbf1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Pcm1 Dynlrb2 Ssna1 Dynlrb1 Ift70b Tubg1 Ift81 Cep63 Dynlt2b Sstr3 Ift80 Cep152 Dynlt5 Tuba4a Dynlt2 Haus4 Haus5 Kif17 Haus6 Pcnt Trip11 Sfi1 Dync2i1 Haus1 Dync2li1 Dync2i2 Cluap1 Traf3ip1 Mkks Ift20 Unc119b Arl13b Cep250 Ift22 Pkd1 Cep290 Cep78 Ift27 Rp2 Cep76 Ift25 Asap1 Cep72 Ift56 Bbs9 Bbs7 Cep164 Cep70 Bbs5 Ift43 Cpap Bbs4 Tubb5 Cct3 Ift46 Plk4 Cct2 Ift74 Odf2 Bbs10 Ift70a2 Bbs12 Alms1 Thoc2l Cetn2 Cngb1 Exoc3 Cep135 Exoc4 Cep43 Exoc5 Cep41 Exoc6 Cep131 Exoc1 Tubb4b Exoc2 Tubb4a Exoc7 Ninl Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Pde6d Ttc8 Nphp3 Lztfl1 Mchr1 Hsp90aa1 Rab11a Pafah1b1 Dync1h1 Kifap3 Dync1i2 Kif3b Tnpo1 Kif3c B9d2 Nde1 Nek2l1 Rho Clasp1 Ywhae Plk1 Smo Cdk1 Mapre1 Dynll1 Dynll2 Ckap5 Csnk1e Rab3ip DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%10224547 Deactivation of the beta-catenin transactivating complex Sry3 Lef1 Sry Xpo1 Uba52 Ctnnbip1 Apc Ctnnb1 Sox3 Btrc Sox9 Kmt2b Sox7 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Xiap Ubb Hdac1 Ubc Tcf7 Wdr5 Ash2l Sox13 Tcf7l1 Tcf7l2 Akt2 Sox17 Akt1 Bcl9l Bcl9 Cby1 Rps27a Ctbp1 Rbbp5 Chd8 Ywhaz TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 96%10224901 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Steap3 Bnip3l LOC134478826 Atm RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223021 Retrograde neurotrophin signalling Cltc Dnal4 Ap2a2 Ap2a1 Ap2b1 Ntrk1 Sh3gl2 Ngf Ap2m1 Clta Ap2s1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%10222729 PKB-mediated events Pde3b ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223655 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2b Adra2a Adra2c TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Arl2bp Slc29a4 Slc28a3 Slc28a2 Slc28a1 Slc25a5 Slc25a4 Arl2 Slc29a3 Slc29a2 Slc29a1 DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors Drd3 Drd4 Drd5 Drd2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 96%10223383 Vitamin D (calciferol) metabolism Ldlrap1 Lgmn Sumo3 Pias4 Cyp24a1 Cyp27b1 Ube2i Vdr Cubn Gc Lrp2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism A4galt Cerk M6pr B3galnt1 Ugcg B4galnt1 Ugt8 Gal3st1 B3gnt5 St8sia5 Arsa Smpd2 Neu2 Smpd3 Neu3 Smpd4 Neu4 Smpd1 Neu1 Gba1 Gba3 St6galnac5 Gba2 St6galnac6 Enpp7 Galc Asah2 Asah1 Sts Gm2a St3gal5 Arsl St3gal2 Arsk St3gal3 Arsj Arsi Arsg Gla Sumf1 Glb1 Arsb Sumf2 Ctsa Fut2 Fut1 B3galt4 Glb1l Psap B4galt5 B4galt6 Glb1l3 Glb1l2 Hexa Hexb FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-RNO-75105.1 Fatty acyl-CoA biosynthesis Cbr4 Tecr Acsbg1 Acsbg2 Acaca Hsd17b3 Fasn Hsd17b12 Hacd1 Hacd2 Hacd3 Hacd4 Hsd17b8 Elovl2 Acly Elovl3 Elovl5 Elovl1 Elovl6 Elovl7 Slc27a2 Tecrl Ppt2 Ppt1 Acsf3 Scd1 Morc2 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 96%10223301 Energy dependent regulation of mTOR by LKB1-AMPK Prkab2 Prkab1 Lamtor3 Lamtor2 Rptor RragB Prkaa1 Ppm1a Prkaa2 Mtor Stradb Rheb Cab39 Strada Slc38a9 Lamtor5 Prkag3 Lamtor4 Prkag1 Rraga Prkag2 Tsc2 Lamtor1 Tsc1 Rragc Rragd Stk11 Mlst8 Cab39l GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-RNO-888590.1 GABA synthesis, release, reuptake and degradation Aldh5a1 Rims1 Abat Slc6a1 Syt1 Stx1a Stxbp1 Gad1 Gad2 Hspa8 Snap25 Cplx1 Dnajc5 Vamp2 Rab3a Slc32a1 Slc6a11 Slc6a13 Slc6a12 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%10223215 Neuropilin interactions with VEGF and VEGFR Nrp1 Nrp2 Flt1 Kdr GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-RNO-9845576.1 Glycosphingolipid transport GLTP Cptp Esyt1 Cln3 Esyt3 Arf1 Esyt2 Plekha8 PROTEIN UBIQUITINATION%REACTOME%R-RNO-8852135.1 Protein ubiquitination Uchl3 Rnf181 Shprh Rad18 Uba1 Rnf152 Rnf40 Rnf144a Hltf Wac Ube2t Cdc34 Otulin Ube2d3 Ube2d2 Hist1h2bq Usp5 Usp7 Ube2g2 Ube2g1 Ube2s Cdc73 Rps27a Pex2 Ube2c Ube2l3 Ube2r2 Usp9x H2bc4 H2bc1 Pex5 Ube2n Leo1 Uba52 Ube2d1 Ube2w Ube2k Pex14 Ube2v2 Pex13 Ube2b Pex12 Pex10 Ube2a Ubb Prkdc Ubc Bcl10 Ube2e1 Skic8 Pcna Ube2z Rnf20 Ctr9 Paf1 Rraga Uba6 ENSRNOG00000066901 Ube2e3 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%10224243 Acyl chain remodelling of PS Osbpl10 Pla2g4f Pla2g2d Mboat1 Pla2g2f Osbpl5 Pla2g2a Pla2g4e Pla1a Pla2g1b Pla2g4a Osbpl8 Pla2g4d Pla2r1 Pla2g12a Pla2g4b Lpcat4 Pla2g10 Plaat3 Pla2g5 Lpcat3 CELL-CELL COMMUNICATION%REACTOME%R-RNO-1500931.1 Cell-Cell communication Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Kirrel1 Kirrel2 Kirrel3 Xiap Skap2 Nphs1 Fyb1 Grb2 Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Vcl Hdac2 Il6 Il6r Furin Tyrobp Itgb1 Nck2 Prkci Rac1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Kdm1a Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Nck1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Pxn Src Pard3 Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Jak2 Cdh8 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Pard6b Pard6a Kmt5a H2ac4 Sec11c Amot Sec11a Fermt2 Prkcsh Flna Cd47 Flnc Sirt1 Pard6g Vasp Itga6 Zmym2 Cadm3 ENSRNOG00000066901 Sp1 Cdh24 Cadm2 Cadm1 Rnf19b Tesk1 F11r Pomt1 Sdk1 Hace1 Dnttip1 Pomt2 Stat3 Fblim1 Parvb Parva Pcsk7 Pcsk6 Sdk2 Ilk Birc2 H2ac18 Adam19 Afdn Ctbp2 Plec Csnk2a2 Dst Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Sirpa Cdh18 Cdh17 Cd151 Cdh15 Hist1h2bq Itgb4 Cdh13 Ptk2b Cdh12 Actn1 Hdac1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 Megf11 H2aj Canx Tiam1 Arhgap32 Spcs3 Spcs1 Spcs2 Farp2 Smarca4 Pip5k1c H3-3b Hist3h2ba ENSRNOG00000068602 Vav2 H2bc18 H2az2 H2bc4 Hist1h4m H2bc1 Arhgef6 Hist1h2ai Arhgef4 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-RNO-72202.1 Transport of Mature Transcript to Cytoplasm Nup133 Slu7 Nup210 Nup155 Nup153 Thoc2 Thoc3 Thoc5 Thoc6 Thoc7 Magohb Chtop Poldip3 Casc3 Fip1l1 Nxt1 Nxf5 Nxf7 Srsf1 Srsf9 Srsf7 Sympk Srsf5 Srsf3 Srsf2 Cpsf4 Cpsf1 Ncbp2 Cpsf2 Ncbp1 Cpsf3 U2af1 U2af1l4 Rnps1 Gle1 Fyttd1 Cdc40 Ddx39a Nup93 Nup50 Alyref Nxf1 Slbp Nup35 Magoh Ddx39b Nup54 Nup98 Upf3b Sarnp Nup58 Nup37 Pom121 Nup205 Nup107 Dhx38 Sec13 Nup188 Tpr Eif4a3 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Eif4e Rbm8a Aaas Srsf11 Ranbp2 Nup214 Srrm1 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Dvl1 Mrtfa Dvl2 Dvl3 Ppp2r1b Ppp2r1a Rhoa Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Daam1 Evl Srf Rhob Diaph3 Diaph1 Pfn1 Pfn2 Rhoc Scai Fmnl3 Srgap2 Actg1 Rac1 Pafah1b1 Zw10 Knl1 Fmnl2 Fmnl1 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Incenp Bub1b Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Aurkb B9d2 Actb Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Cdc42 Birc5 Ercc6l Ranbp2 Ckap5 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Tpst1 Tpst2 F10 Ggcx Ogfod1 Riox1 Bglap Furin Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Proc Icmt Dhps Riox2 Eif5a Proz Fn3k Fn3krp Eif5a2 Dohh Dph5 Dph6 Eef2 Jmjd6 F2 F8 Etf1 Rpl8 Arsa Sts Pros1 Arsl Arsk Arsj Arsi Arsg Sumf1 Arsb Sumf2 Rps23 Rpl27a F7 F9 Gas6 Rps6 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225357 Regulation of HMOX1 expression and activity Hm13 Hmox1 STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels Mcoln2 Clcn6 Clcn7 Ano10 Clcn4 Ttyh3 Clcn5 Ttyh1 Ttyh2 Slc17a3 Trpc4ap Best4 Calm3 Best1 Best3 Best2 Clca1 Clca2 Clca4 Trpc5 Trpc4 Stoml3 Unc80 Scnn1a Scnn1b Unc79 Trpc7 Scnn1g Trpc3 Lrrk1 Rps27a Trpa1 Tpcn1 Bsnd Mcoln1 Sri Trpm2 Trpm1 Wwp1 Nek4 Ano9 Ano8 Uba52 Trpm8 Ryr2 Trpm7 Ryr1 Ano7 Fkbp1b Trpm4 Ano4 Sgk1 Trpm3 Ano3 Trpm6 Ano2 Ano1 Sgk3 Sgk2 Clic2 Trdn Asic5 Asph Asic4 Trpc1 Stom Ubb Ubc Asic1 Asic3 Asic2 Raf1 Ano6 Ano5 Trpv5 Trpv4 Trpv6 Trpv1 Trpv3 Trpv2 Nalcn Clcn2 Tsc22d3 Clcn1 Clcnkb Clcnka Mcoln3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224263 Transcriptional activation of mitochondrial biogenesis Idh2 Sirt3 Sirt5 Glud1 Acss2 Cycsl2 Cycs Gabpa Sod2 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME DATABASE ID RELEASE 96%10222779 Inhibition of TSC complex formation by AKT (PKB) Tsc2 Tsc1 Akt3 Akt2 Akt1 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 96%10225239 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s NUCLEOTIDE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleotide catabolism Itpa Dnph1 Nudt5 Tymp Upb1 Upp1 Nt5c3a Upp2 Dpys Dpyd Nt5m Samhd1 Pnp Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 Xdh Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins Cyp1a1 Cyp1a2 Lta4h Alox15 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%10222621 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maob Maoa PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 96%10224973 PTK6 Regulates Cell Cycle Ccne1 Cdkn1b Ccnd1 Cdk4 Cdk2 Ptk6 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Ube2s Cdc16 Anapc15 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Anapc7 Cdc20 Ube2e1 UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA Gins2 Gins1 Gins4 Gins3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10223643 Beta-oxidation of very long chain fatty acids Acox1 Ehhadh Abcd1 Eci2 Acot4 Slc27a2 Acaa1b Decr2 Acot8 Mlycd Hsd17b4 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%10224489 SUMO is conjugated to E1 (UBA2:SAE1) Uba2 Sae1 Sumo1 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%10225053 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Npm1 Tfap2a SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10222275 SLC-mediated transport of organic anions Slco2b1 Slc25a10 Slc44a3 Slco2a1 Slc13a2 Slc44a4 Slc25a1 Slco4c1 Slc44a5 SLC16A2 Slc44a1 Slco1c1 Slc44a2 Avp Slc17a5 Slc10a6 Slc22a8 Slc22a7 Slc5a8 Slc22a6 Slc5a7 Slc5a12 Emb Slc16a7 Slc25a11 Slc16a3 Slc16a8 Slc16a1 Bsg Slc22a12 Slco3a1 Slc13a5 Slco1a4 Slco4a1 Slc13a3 Slco1b2 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 96%10221969 Cellular responses to stimuli Suz12 Cox5a Cox5b Eed Gsk3b Hmox1 Rbbp4 Rbbp7 Ube2d3 Ube2d2 Cox4i1 Cox4i2 Ptk2 Mapk3 Mapk9 Ikbkb Mapk7 Mapk8 Ikbkg Cat Nfkb1 Fos Rela Rps6ka3 Rps6ka1 Rps6ka2 Map2k7 Map2k6 Lamtor3 Lamtor2 Vcl Mapkapk3 Mapk14 Jun Mapkapk2 Nfkbia H1-1 H1-0 Map2k3 H1-5 H1-4 H4f3 Chuk Mapk10 Mapk11 Creb3l3 Crebrf Itgav Gpx2 Gpx1 Ncoa2 Atp6v0b Itgb1 Itgb3 Atp6v1g3 Atp6v0e2 Atp6v1c2 Ern1 Atp6v1c1 Terf2 Atp6v0c Acd Terf1 Terf2ip Atp6v1e2 Tinf2 Atp6v1e1 Pot1 Tcirg1 Txnrd1 Atp6v1a Atp6v1b2 Akt3 Atp6v0d2 Akt2 Atp6v0d1 Akt1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Gsr Atp6v1g1 Atp6v1f Ccne1 Atp6v1d Ccne2 Cdkn2b Cdkn2d Ppp2r2a Hspa8 Rpa1 Rpa2 Rpa3 Cdkn1b Ywhae Rptor RragB Mtor Rheb Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Rragd Mlst8 Map1lc3b Ep400 Asf1a Cabin1 Hira Ubn1 Hmga2 Hmga1 Anxa2 Gstp1 Map3k5 Tnik Mink1 Map4k4 Camk2g Camk2d Camk2b Camk2a Oma1 Mre11 Eloc Kat5 Elob Nbn Ncf1 Ncf2 Ncf4 Hsph1 Dnajc2 Cryab Hikeshi Hspa14 Hspa13 Rps19bp1 Hsbp1 St13 Hspa12b Hspa12a Bag5 Bag3 Bag2 Bag1 Hspb8 Dnajb6 Hspa9 Atm Hspa4 Sirt1 Clec1b Rad50 Ehmt1 Kdm6b Hspa5 Cyba Cybb Cul2 Sod1 Eif2s3 Med1 Eif2s2 Eif2s1 Trim21 Vhl Dync1h1 Xpo1 Dync1i2 Dync1i1 Ajuba Mbtps1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Tgs1 Nup188 Dync1li2 Tpr Nup160 Dync1li1 Rae1 Ndc1 Trpv4 Dynll1 Dynll2 Nup85 Mdm4 Nup42 Nup62 Nup43 Nup88 Ly96 Aaas Ranbp2 Nup214 Tlr4 Nup133 Nup210 Nup155 Nup153 Fabp1 Blvrb Hmox2 Pdpk1 Blvra Abcc1 Hsf1 Dnaja1 Hspa1b Sirt3 Hspa1a Alb Arnt Apoa1 P4hb Nploc4 Apob Stip1 Pgrmc2 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Txn Ptpn1 Hsp90ab1 Cycsl2 Ikbke Cycs Sod2 Adm Pkn2 Capn2 Prkci Psma4 Ccna1 Psma3 Capns1 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Eef1a1 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp1 Psmb5 Psmb4 Calcrl Psmb7 Rxra Psmb6 Psmb1 Psmb3 Pgr Psmb2 Uba52 Anapc10 Tbl1x Ube2d1 Anapc16 Btrc Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Hdac3 Fzr1 Ubb Hspa1l Anapc7 Tbl1xr1 Slc46a1 Ubc Foxo3 Ube2e1 Psmb6l1 Psmd7 Rb1 Psmd6 Fkbp4 Hspa2 Psmd8 Fkbp5 Ptges3 Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Carm1 Cul1 Cdk2 Cdc16 Egln1 Egln2 Egln3 Epas1 Mapk1 Nos3 Hif3a Ramp2 Wtip Mt-co1 Limd1 Gng10-ps1 Ar Hif1a Keap1 Actr1a Ppp2ca Ufd1 Dctn1 Mt2 Dctn2 Mt3 Prkaca Prkacb Dctn4 Higd1c Cited2 Gna11 Prkar1a Prkar1b Calm3 Gng3 Mul1 Gng5 Gng4 Gnaq Gng7 Pde4d Gng8 Gngt1 Prkar2a Prkar2b Sesn2 Ppp2r1b Sesn1 Ppp2r1a Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gnas Cox7a1 Cox7a2 Actr10 Cox7a2l Hba1 Hbb P2ry2 Tp53 H2ab2 H2ac4 Ring1 Abl1 ENSRNOG00000066901 Phc2 Nr3c2 Cbx6 Nr3c1 Phc1 Cbx4 Cbx2 Esr1 Phc3 Stat1 Crebbp Ndufa4 Cdk6 H2ac18 Ppara Sin3a Sin3b Bmi1 Prdx2 Prdx5 Hist1h2bq Srxn1 Prdx1 Nfe2l2 H2aj H3-3b Yap1 Hist3h2ba Sqstm1 Ep300 Rnf2 ENSRNOG00000068602 Smarcd3 Cox6a1 Cox6a2 Txn2 H2bc18 Bach1 H2az2 H2bc4 Hist1h4m H2bc1 Cox6c2 Hist1h2ai Cox6b1 Prdx3 Cox6b2 Atf6 Prdx6 Rictor Nprl3 Nprl2 Wdr59 Prr5 Nox4 Mios Depdc5 Wdr24 Erf Mapkap1 Gpx3 Gpx6 Gpx5 Gpx8 Gpx7 Cebpb Fnip1 Fnip2 Samtor Hm13 Hif1an Eif2ak3 Id1 Itfg2 Castor2 Prkaa2 Castor1 Nudt2 Cox8a Ubxn7 Rbx1 Ets1 Cox8c Ets2 Ero1a Szt2 Vcp Atf6b Cox7b Txnrd2 Dnaja2 Cox7c Dnaja4 Kics2 Sod3 Flcn Ccs Sh3bp4 Cdk4 Dnajb1 Cul3 Mapkapk5 Ezh2 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224427 Scavenging by Class H Receptors Sparc Apob Stab1 DECTIN-2 FAMILY%REACTOME%R-RNO-5621480.1 Dectin-2 family Fyn Clec4e Clec4d Fcer1g Clec6a-ps1 Syk Lyn Plcg2 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224811 RAF activation Ppp2r5b Ppp2r5a Phb1 Ppp2cb Ppp2ca Ksr1 Araf Ppp1cc Ppp1cb Map2k2 Ppp2r5e Map2k1 Map3k11 Calm3 Ppp2r5d Brap Raf1 Jak2 Braf Ppp2r1b Shoc2 Ppp2r1a Mark3 Mras Src Nras Kras Camk2g Camk2d Hras Camk2b Ywhab Camk2a SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-RNO-480985.1 Synthesis of dolichyl-phosphate-glucose Nudt14 Alg5 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222101 Carnitine synthesis Bbox1 Tmlhe Aldh9a1 Shmt1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-RNO-5654716.1 Downstream signaling of activated FGFR4 Frs2 Plcg1 Frs3 Klb Fgf2 Fgf1 Fgf4 Fgf6 Fgf8 Fgfr4 Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Fgf19 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Gab1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-RNO-195399.1 VEGF binds to VEGFR leading to receptor dimerization Flt1 Flt4 Vegfa Kdr Vegfd Vegfc Pgf Vegfb PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 96%10224979 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Rps27a Uba52 Dok1 Ubb Arap1 Akt1 Ubc Ptk6 Cbl PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance Ldlrap1 Lipa Lipc Soat2 Soat1 Uba52 Scarb1 Apoc1 Apoc4 Vldlr Cubn Ubb Nceh1 Ubc Ap2m1 Clta Cltc Apobr Mylip Npc2 Npc1 Ldlr Amn Apoa1 Ap2s1 Hdlbp Rps27a Apoe Apob Ap2a2 Ap2a1 Ap2b1 Nr1h3 Pcsk9 Nr1h2 WAX BIOSYNTHESIS%REACTOME%R-RNO-9640463.1 Wax biosynthesis Awat2 Awat1 Far2 Far1 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 96%10224369 Signaling by Hippo Dvl2 Nphp4 Tjp2 Mob1a Ywhae Lats1 Mob1b Lats2 Wwc1 Amotl2 Tjp1 Amotl1 Stk4 Yap1 Stk3 Sav1 Amot Casp3 Wwtr1 Ywhab RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-RNO-9954709.1 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a LOC134480579 Rpl23a Eloc Elob Ltn1 Cul2 Tcf25 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Rpl4 Rpl5 Rpl3 Psmb5 Rpl35 Psmb4 Psmb7 Rpl36 Psmb6 Rpl37 Rpl38 Psmb1 Rpl39 Psmb3 Rpl8 Psmb2 Rpl9 Uba52 Rpl6 Ube2d1 Rpl7 Psma7 Rpl30 LOC134486107 Rpl31 Rpl32 Psmc5 Psmc2 Rpl34 Psmc1 Rpl36al1 Psmc4 Psmc3 Rpl39l1 Rchy1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Ubb Rpl12-ps1 Ubc Rpl22 Psmb6l1 Rpl23 Psmd7 Nemf Psmd6 Psmd8 Psmd2 LOC120097744 Psmd1 Adrm1 Rbx1 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Klhdc10 LOC100910714 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223949 Organic anion transport by SLC22 transporters Slc22a7 Slc22a6 Slc22a12 Slc22a8 HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224391 Hyaluronan degradation Hyal5 Chp1 Hyal4 Slc17a5 Hyal3 Cemip Hyal1 Gusb Chp1l1 Hyal2 Cd44 Slc9a1 Hexa Hexb CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors Ramp3 Iapp Calcb Calcr Ramp2 Calca Adm Adm2 Ramp1 Calcrl FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190377.1 FGFR2b ligand binding and activation Fgfbp3 Fgfbp1 Fgf2 Fgf1 Fgf3 Fgf10 Fgf22 Fgf7 Fgfr2 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 96%10224963 Signaling by PTK6 Erbb2 Ccnd1 Erbb3 Ereg Uba52 Stat3 Stap2 Nrg2 Gpnmb Lrrk2 Nrg3 Dok1 Btc Arhgap35 Rasa1 Egf Elmo1 Ubb Elmo2 Arap1 Ubc Pxn Cdkn1b Egfr Bcar1 Ptpn1 Rac1 Sfpq Khdrbs1 Khdrbs3 Hbegf Khdrbs2 Akt1 Cdk2 Socs3 Rhoa Cbl Nras Ccne1 Rps27a Kras Hras Cdk4 Srms Hif1a Crk Ptk6 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-RNO-9754119.1 Drug-mediated inhibition of CDK4 CDK6 activity Ccnd1 Cdk6 Cdk4 Ccnd2 Ccnd3 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223231 PI3K AKT activation Pik3r2 Irs2 Pik3ca Irs1 Ntrk1 Ngf Pik3r1 Pik3cb Rhoa CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-RNO-389359.1 CD28 dependent Vav1 pathway Grb2 Cd86 Fyn Cd80 Vav1 Pak1 Rac1 Pak3 Lck Pak2 Cdc42 Cd28 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223849 GP1b-IX-V activation signalling Raf1 Gp5 Gp9 Gp1bb Gp1ba Src Pik3r1 Ywhaz HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%10224527 HDMs demethylate histones Kdm4c Kdm5b Kdm6b Kdm7a Phf2 Kdm4d Phf8 Arid5b Kdm4b Uty Kdm4a Kdm5c Kdm5a Kdm6a H2bc18 Jmjd6 Kdm2b Kdm1b Riox2 Hist1h4m Kdm1a Kdm3b Kdm3a POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223957 Postsynaptic nicotinic acetylcholine receptors Chrnb4 Chrnb3 Chrnb2 Chrnd Chrne Chrna3 Chrng Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrna4 Chrna9 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 96%10224245 Acyl chain remodelling of PE Plaat5 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Lpcat4 Pla2g10 Plaat3 Pla2g5 Pla2g3 Pla2g6 Abhd4 Mboat1 Mboat2 Pla2g4a Pla2g4b Lpcat3 Pnpla8 Plaat1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 96%10222739 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Mvd Srd5a3 Dpm2 Dpm1 Dpm3 Gmppa Alg9 Pmm2 Mpi Alg8 Alg6 Pmm1 Alg3 Alg2 Alg13 Alg14 Alg12 Mpdu1 Dpagt1 Nagk Gnpnat1 Amdhd2 Uap1 St8sia6 Gfpt1 St8sia4 Gfpt2 Pgm3 St8sia5 Renbp Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 Dhdds St3gal6 Nudt14 St6galnac2 Alg5 St3gal4 Dolpp1 St3gal5 Fuom St3gal2 Gmds St3gal3 Slc35a1 Dolk Fcsk St3gal1 Dhrsx Nanp St6gal1 Nus1 Glb1 Fpgt St6gal2 Gfus Slc35c1 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 96%10223165 Metabolism of steroid hormones Hsd3b Lhb Fdx1 Hsd17b3 Cga Cyp17a1 Hsd3b6 Akr1b10 Hsd3b5 Srd5a3 Hsd11b1 Sts Hsd3b1 Hsd11b2 Srd5a1 Hsd17b12 Srd5a2 Hsd3b5-ps1 Serpina6 Pomc Akr1b1 Stard4 Star Tspoap1 Stard6 Cyp11a1 Tspo Fdx2 Fdxr Cyp21 Cyp11b3 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Cyp11b1 Cyp11b2 Cyp19a1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Blm Wrn Dna2 Ppp4r2 Pias4 Ube2n Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Sirt6 Rad51c Rad51b Chek1 Ube2v2 Rad9a Rad9b Bard1 Top3a Palb2 Firrm Ppp4c Lig1 Clspn Rad17 Xrcc3 Rfc5 Slx1b Pold2 Xrcc2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Atm Rfc2 Atr Pold4 Tp53bp1 Pold3 Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 Abl1 Brcc3 ENSRNOG00000066901 Herc2 Rnf168 ABRAXAS1 Sumo3 Rnf8 Rhno1 Slx4 Nsd2 Spidr Rad51 Rad50 Rad52 Ercc1 Ercc4 Babam1 Babam2 Topbp1 Rbbp8 Brca2 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Rad1 Polh Ccna1 Ccna2 Hist3h2ba Rps27a H2bc4 Hist1h4m H2bc1 Uba52 Pole3 Pole2 Pole4 Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Cdk2 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 96%10223325 WNT mediated activation of DVL Dvl2 Csnk2b Dvl3 Csnk2a2 Csnk2a1 Pip5k1b Csnk1e Dvl1 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10225443 TGFBR3 regulates activin signaling Tgfbr3 Inha Acvr2a Inhba DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224167 Downregulation of ERBB4 signaling Itch Wwp1 Rps27a Uba52 Nedd4 Ubb Src Ubc GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10224079 Growth hormone receptor signaling Prlr Mapk1 Sh2b1 Jak2 Ptpn1 Lyn Mapk3 Stat5a Ghr Stat5b Gh1 Prl FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%10222603 FMO oxidises nucleophiles Fmo1 Fmo3 Fmo2 PTK6 ACTIVATES STAT3%REACTOME%R-RNO-8849474.1 PTK6 Activates STAT3 Stat3 Stap2 Socs3 Ptk6 PLC BETA MEDIATED EVENTS%REACTOME%R-RNO-112043.1 PLC beta mediated events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Grk2 Gnaq Prkar2a Prkar2b Pde1b Pde1c Pde1a Plcb4 Plcb3 Mapk1 Pla2g4a Plcb2 Plcb1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol Ocrl Inpp5j Miox Isyna1 Synj1 Inpp1 Inpp4a Impa2 Inpp4b Impa1 Inpp5a Inpp5b GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 96%10223561 Glycoprotein hormones Fshb Inha Lhb Inhba Cga Inhbb Tshb Inhbc Inhbe IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 96%10222231 IRS-related events triggered by IGF1R Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Igf1r Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Igf2 Fgfr2 Fgf16 Them4 Igf1 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Sos1 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225365 Drug-mediated inhibition of MET activation Hgf Met FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope Klk8 Sprr3 Tgm1 Stfa2l3 Casp14 Evpl Spink6 Cela2a Spink5 Perp Klk12 Pkp2 Pkp3 Dsg3 Lipk Dsg4 Dsc2 Rptn Lipm Klk14 Dsc3 Dsp Jup Lipn Dsg1 Dsg2 Klk13 Ppl Pkp1 Dsc1 Cdsn Klk5 Kazn REGULATION OF CDH11 FUNCTION%REACTOME%R-RNO-9762292.1 Regulation of CDH11 function Jup Ctnnd1 Ctnnb1 Cdh11 Amot Adam19 Angptl4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%10224011 N-glycan trimming in the ER and Calnexin Calreticulin cycle Canx Calr Rad23b Uba52 Vcp Rps27a Psmc1 Ubxn1 Amfr Pdia3 Engase Ngly1 Ubb Ubc REGULATION OF TNFR1 SIGNALING%REACTOME%R-RNO-5357905.1 Regulation of TNFR1 signaling Ikbkg Uba52 Traf2 Ube2d1 Sharpin Tnf Otud1 Tnfrsf1a Birc2 Traf1 Mib2 Spata2 Rnf31 Rack1 Otulin Ube2d3 Usp2 Ube2d2 Clip3 Xiap Sppl2b Ubb Sppl2a Usp4 Ubc Casp8 Tbk1 Mapkapk2 Madd Tax1bp1 Ikbke Tradd Cflar Cyld Optn Stub1 Ripk1 Rps27a Otud7b Fadd Rbck1 Chuk Ube2l3 Ikbkb Ulk1 Usp21 DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER Xab2 Cdk7 Ppie Ercc1 Ercc4 Tcea1 Mnat1 Polk Prpf19 Usp7 Isy1 Rps27a Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ercc6 Polr2i Polr2j Gtf2h2 Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Pole3 Pole2 Pole4 Znf830 Rpa1 Rpa2 Aqr Uvssa Ubb Rpa3 Ubc Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Ccnh Pold4 Pold3 Xpa Ddb1 Cul4a Cul4b MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%10222845 MAPK targets Nuclear events mediated by MAP kinases Ppp2cb Ppp2ca Fos Vrk3 Rps6ka3 Rps6ka1 Rps6ka2 Ppp2r5d Dusp3 Dusp4 Dusp7 Creb1 Dusp6 Mapk14 Jun Ppp2r1b Mapkapk2 Ppp2r1a Mapk3 Rps6ka5 Mapk1 Mapk9 Mapk10 Atf2 Mapk11 Atf1 Mapk7 Mapk8 PECAM1 INTERACTIONS%REACTOME%R-RNO-210990.1 PECAM1 interactions Inpp5d Fyn Ptpn11 Ptpn6 Lck Pecam1 Itgb3 Lyn Plcg1 Yes1 Itgav Src G2 PHASE%REACTOME%R-RNO-68911.1 G2 Phase Ccna1 Ccna2 Cdk2 E2f1 E2f3 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 96%10223307 MDK and PTN in ALK signaling Ptprz1 Alk Mdk Ptn GLYCINE DEGRADATION%REACTOME%R-RNO-6783984.1 Glycine degradation Amt Gcsh Dld AC132020.1 Ogdh Dlst Kgd4 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 RNA POLYMERASE I PROMOTER OPENING%REACTOME%R-RNO-73728.1 RNA Polymerase I Promoter Opening Hist1h2ai H2aj H2ab2 H3-3b Mapk3 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Mbd2 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Ubtf H2bc1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%10223407 Platelet Adhesion to exposed collagen Fyn Gp6 Fcer1g Lyn SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 Memo1 Grb7 Erbb2 Erbb3 Ereg Uba52 Ptpn12 Nrg2 Nrg3 Prkcd Btc Prkca Egf Cul5 Ubb Ubc Ptpn18 Usp8 Ptk7 Prkce Egfr Rnf41 Pik3ca Shc1 Akt3 Hbegf Akt2 Akt1 Yes1 Src Pik3r1 Rhoa Hsp90aa1 Stub1 Nras Rps27a Diaph1 Grb2 Fyn Kras Cdc37 Sos1 Hras Ptk6 Gab1 CHYLOMICRON REMODELING%REACTOME%R-RNO-8963901.1 Chylomicron remodeling Apoe Apoa4 Apob Apoc2 Lpl Apoa1 Gpihbp1 Apoc3 Apoa5 Apoa2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements Zfp36l1 Khsrp Dis3 Prkcd Prkca Hspa1b Zfp36 Hspa1a Psma4 Psma3 Akt1 Psma6 Psma5 Psma2 Psma1 Exosc9 Rps27a Tnfsf13 Exosc8 Psmd12 Exosc5 Psmd11 Exosc4 Psmd14 Exosc7 Psmd13 Exosc6 Exosc1 Exosc3 Exosc2 Pabpc1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Psma7 Hspa8 Tnpo1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anp32a Ubb Ubc Dcp1a Psmb6l1 Parn Xrn1 Psmd7 Psmd6 Set Psmd8 Psmd2 Mapkapk2 Psmd1 Adrm1 Elavl1 Hnrnpd Hspb1 Dcp2 Ywhab Nup214 Ywhaz EPH-EPHRIN SIGNALING%REACTOME%R-RNO-2682334.1 EPH-Ephrin signaling Rasa1 Actg1 Sdcbp Efnb1 Arhgef7 Rock2 Efnb2 Rock1 Efnb3 Ephb1 Ephb2 Ephb3 Ephb4 Tiam1 Ephb6 Nck2 Rac1 Pak1 Pak3 Git1 Pak2 Ptk2 Lyn Yes1 Src Rhoa Rlc-a Ngef Vav3 Fyn Vav2 Itsn1 Hras Psenen Psen1 Psen2 Sdc2 Kalrn Ncstn Aph1a Grin1 Aph1b Grin2b Epha2 Arpc3 Arpc2 Actb Arpc5 Arpc4 Mmp2 Efna1 Efna2 Epha1 Epha3 Mmp9 Epha4 Epha5 Epha6 Epha7 Epha10 Efna4 Efna5 Arpc1b Actr2 Arpc1a Actr3 Arhgef28 Cdc42 PROSTANOID LIGAND RECEPTORS%REACTOME%R-RNO-391908.1 Prostanoid ligand receptors Ptgdr2 Ptger2 Ptger3 Ptgdr Ptger1 Ptgdrl Ptgir Ptger4 Ptgfr Tbxa2r SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223661 Serotonin receptors Htr1d Htr1f Htr4 Htr2a Htr1b Htr2c Htr6 Htr1a Htr2b Htr7 Htr5a RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 96%10222509 Response of endothelial cells to shear stress Ppp2ca Pdpk1 Stat1 Prkaca Prkacb Gna11 Prkar1a Anxa2 Prkar1b Adm Itgb1 Calm3 Gng3 Itgb3 Gng5 Pkn2 Gng4 Gnaq Gng7 Pde4d Capn2 Gng8 Gngt1 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Ptk2 Capns1 Yap1 Akt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Ikbkb Gnas Calcrl Ikbkg Ppp2r2a Nfkb1 Rela Rictor Prr5 Mapkap1 P2ry2 Vcl Ptpn1 Mtor Ikbke Nfkbia Nos3 Trpv4 Ramp2 Gng10-ps1 Chuk Abl1 Itgav Mlst8 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-RNO-199992.1 trans-Golgi Network Vesicle Budding Ttgn1 Igf2r M6pr Ocrl Napa Bloc1s3 Bloc1s4 Bloc1s6 Hgs ENSRNOG00000062839 Snap23 Tpd52 Snapin Arf1 Tbc1d8b Golgb1 Vamp2 App Tpd52l1 Tfrc Dnajc6 Dtnbp1 Clvs1 Dnase2 Clvs2 Ap4b1 Fth1-ps5 Pik3c2a Ap1b1 Chmp2a Ap1m2 Vamp7 Bloc1s1 Ap1m1 Vamp8 Fth1 Ap4s1 Ap1s3 Ap1s2 Arrb1 Txndc5 Necap1 Ap1g2 Ap1g1 Ap4m1 Hspa8 Ap4e1 Hip1r Cpd Snx2 Gbf1 Snx9 Picalm Snx5 Pum1 Dnm2 Ftl1 Gak Yipf6 Clta Cltb Sort1 Ap3b1 Cltc Sh3d19 Acbd3 Gns Sh3gl2 Rab5c Ctsz Stx4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 96%10224603 Asymmetric localization of PCP proteins Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Wnt5a Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fzd7 Ubb Ubc Dvl2 Psmb6l1 Psmd7 Fzd3 Prickle1 Psmd6 Psmd8 Fzd1 Fzd2 Psmd2 Psma4 Fzd5 Fzd4 Psmd1 Psma3 Adrm1 Pard6a Fzd8 Psma6 Psma5 Psma2 Smurf1 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%10224061 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation Peli1 Peli2 Ikbkg Peli3 Ube2n Chuk Ikbkb Irak1 Traf6 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases Cradd Pidd1 Casp2 Atm RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures Mre11 Slx4 Eme2 Kat5 Spidr Eme1 Rad51 Rad50 Nbn Gen1 Rad51c Rad51b Rbbp8 Brca2 Brca1 Rad51ap1 Bard1 Top3a Palb2 Firrm Xrcc3 Slx1b Xrcc2 Atm Exo1 Mus81 Rmi2 Fignl1 Rmi1 Blm Brip1 Wrn Dna2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223835 Organic cation transport Slc25a26 Slc22a3 Slc14a2 Slc67a1 Slc14a1 Slc47a1 Slc22a2 Slc22a5 Slc22a1 Slc22a4 Slc22a15 Runx1 Slc22a16 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-RNO-196836.1 Vitamin C (ascorbate) metabolism Slc23a2 Cyb5r3 Slc2a1 Cyb5a Slc2a3 Gsto1 Slc23a1 Gsto2 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Gtf3a Crcp Polr3a Brf2 Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr3f Polr3g Pou2f1 Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA IFNB signaling Ptpn1 Stat1 Ptpn6 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Ifnb1 Ifna4 Ifna1 Ifna1l1 Ifna4l1 Usp18 Tyk2 Ptpn11 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223499 Rap1 signalling Rap1gap Raf1 Rapgef4 Rapgef3 Rasgrp2 Prkaca Prkacb Prkg1 Rasgrp1 Rap1a Rap1b Sipa1 Rap1gap2 Ywhab Ywhaz SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%10222091 Signaling Pathways Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Wnt11 Gnao1 Nlk Fzd3 S100a9 Prkcb Atp6v0b Trib3 Atp6v0a4 Grb10 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Ptprf Them4 Pde3b Tlr9 Atp6ap1 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Steap3 Tfrc Stap2 Gpnmb Lrrk2 Dok1 Jag2 Dll1 Dll4 Lbr Gopc Spry1 Cgn Rhoq Pcsk5 Nedd4 Sh3rf1 Rnf111 Snap23 Mkrn1 Rbck1 Wwp1 Ncf1 Ncf2 Ncf4 Vps26a Vps35 Ube2m Vps29 Wnt10a Wnt10b Wls Fzd7 Wnt9a Wnt9b Wnt7a Tmed5 Wnt5b Ror1 Ror2 Wnt6 Wnt2 Wnt4 Wnt2b Wnt16 Rnf41 Prickle1 Lrrc41 Nsmaf Cyba Cybb Cul5 Vhl Rbbp6 Mst1 Mst1r Ptpru Grap Fer Strap Bambi Rhot2 Mfn1 Mfn2 Trak1 Myo19 Trak2 Rpgrip1l Otulin Tulp3 Adcy10 Ift140 Disp2 Scube2 Kif3a Fuz Hhat Mks1 Ift52 Ttc21b Ift57 Mob1a Ift122 Ofd1 Lats1 Mob1b Intu Wdr35 Lats2 Dync2h1 Wwc1 Amotl2 Ift172 Wdr19 Amotl1 Notum Stk4 Stk3 Syvn1 Sav1 Crkl Rapgef1 Ntrk3 Ntf3 Acvr2a Cpsf7 S100a8 Srgap1 Arhgap45 Slk Cavin1 Daam1 Pgrmc2 Tex2 Bcr Arhgap6 Arhgap5 Arhgap4 Sowahc Clip3 Arhgap1 Stom Sppl2b Arap1 Sppl2a Arap3 Alk Arap2 Mdk Ptn Arhgap9 Ptpn18 Arhgap8 Mcam Ptk7 Pld1 Ccdc115 Rtkn Rhpn1 Rhpn2 Stk10 Stard8 Maco1 Ddrgk1 Faf2 Arhgdib Bmpr1a Gmip Bmpr1b Anln Acvrl1 Arhgap10 Amh Iqgap3 Zfyve9 Diaph3 Fam83a Diaph1 Fam83d Arhgap19 Smad9 Arhgap18 Depdc1b Smad5 Smad6 Cit Fam13a Pdgfc Pdgfd Arhgef28 C1qbp Zfyve16 Arhgap22 Acvr1c Arhgap21 Acvr1b Arhgap20 Acvr2b Arhgap26 Gdf2 Arhgap24 Dtx2 Arhgap23 Amhr2 Arhgap29 Grem2 Arhgap28 Cilp Ophn1 Bmpr2 Stbd1 Cer1 Dock2 Thbs4 Def6 Vapb Pcdh7 Myo9b Emc3 Arhgap11a Myo9a Arhgap31 Arhgap30 Prex2 Actc1 Arhgap35 Fmnl3 Tagap Racgap1 Plekhg6 Tmem87a Plekhg3 Bcap31 Ktn1 Farp1 Dlc1 Stard13 Arhgap40 Pkn2 Rock2 Rock1 Pkn1 Arhgap44 Arhgap42 Tjp2 Prkci Elf3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Skp1 Cdc20 Psmb5 Psmb4 Gatad2a Psmb7 Gatad2b Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Ube2d1 Bub1b Btrc Psma7 Nck1 Aurkb Psmc5 Actb Psmc2 Psmc1 Psmc4 Psmc3 Ptpn2 Ubb Ubc Psmb6l1 Cdc14a Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdk1 Plcb4 Plcb3 Mapk1 Pla2g4a Pdyn Plcb2 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Ppp2cb Grb7 Ppp2ca Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Fgfrl1 Prkar1b Calm3 Ppp2r5d Flt1 Gng3 Flt4 Grk2 Vegfa Gnal Kdr Pomc Vegfd Gng5 Vegfc Gng4 Pgf Pde4c Vegfb Gnaq Il1rap Gng7 Pde4d Gng8 Gngt1 Irak4 Gnat3 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Cdk5 Pde1b Pde1c Gnb2 Gnb1 Pde1a Gnb4 Gnb3 Gnb5 Gng11 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Git2 Arhgap12 Epha2 Zfp512b Adra2a Dlg5 Adora2b Adora2a Adra2c P2ry2 Ckap4 Parp1 H2ab2 Ptbp1 H2ac4 Gata3 Ring1 Abl1 ENSRNOG00000066901 Phc2 Cbx6 Ccnd3 Phc1 Cbx4 Cbfb Ccnd1 Cbx2 Esr1 Phc3 Crebbp Kmt2b H2ac18 Csnk2a2 Csnk2a1 Bmi1 Hist1h2bq Prmt1 Hdac1 Wdr5 Ash2l Csnk2b H2aj Smarca4 H3-3b Yap1 Hist3h2ba Ep300 Rnf2 ENSRNOG00000068602 Itch Ptpn11 H2bc18 Runx1 Kat2b H2az2 Rbbp5 H2bc4 Hist1h4m H2bc1 Pml Hist1h2ai Hnrnpa1 Ddx39b Prkaa1 Prkaa2 Derl2 Rbx1 Spop Vcp Hnrnpc Prkag3 Prkag1 Hnrnpf Prkag2 Cdk4 Cul3 Ezh2 Erlec1 Srrm1 Ywhag Suz12 Eed Gsk3b Os9 Hnrnph1 Sel1l Rbbp4 Rbbp7 Mib2 Prkab2 Prkab1 Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 Ybx1 Creb1 Spta1 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Mapk3 Sptan1 Sptbn5 Rps6ka5 Nras Sptbn4 Grb2 Fyn Rbmx Kras Sos1 Hras Tra2b App Atf2 Ikbkb Atf1 Mapk7 Iqgap2 Mapk8 Traf6 Ikbkg Map3k7 Nfkb1 Traf2 Tjp1 Sharpin Tnf Fos Otud1 Vrk3 Tnfrsf1a Traf1 Spata2 Rela Rnf31 Rps6ka3 Rps6ka1 Rps6ka2 Dusp3 Dusp4 Ripk2 Dusp7 Dusp6 Casp8 Mapkapk3 Mapk14 Jun Mapkapk2 Irak1 Nfkbia Tab3 Tab2 Tab1 Chuk Mapk11 Itga8 Itgav Bmp10 Tgfb1 Tgfb2 Tgfb3 Ltbp3 Ltbp2 Furin Ltbp4 Ltk Tnk2 Alkal2 Ltbp1 Alkal1 Ccnk Itgb8 Ccnt2 Itgb6 Itgb1 Bmp2 Itgb3 Kif5a Kif5b Madd Akt3 Akt2 Akt1 Optn Dock5 Dock6 Dock3 Dock4 Tsc2 Dock7 Tsc1 Dock8 Ulk1 Klc1 Klc4 Rab4a Klc3 Klc2 Dock10 Dock11 Sh2b2 Rab7a Prkch Prkce Ywhae Mgll Pik3r6 Als2 Arf6 Rab9a Rab9b Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Itga3 Dgkh Dgki Ckb Dgkk Dgkq Dgkz Itpr3 Itpr2 Itpr1 Pde10a Lyn Daglb Yes1 Src Rhoa Ngef Trpc7 Trpc3 Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dagla Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Tgfbr3 Pde11a Gipc1 Arrb2 Arrb1 Tgfbr1 Tgfbr2 Lhb Cga Zap70 Aamp Lck Thbs1 AABR07021573.2 Igf2 Igf1 Raf1 Jak2 Rhog Rhob Rac2 Ctsd Agt Cma1 Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Plat Qrfprl Qrfpr Qrfp Pde2a Hcrt Dkk4 Kremen2 Kremen1 Lrp6 Sost Dkk1 Dkk2 Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Pik3cd Epo Gab1 Pik3r5 Pik3cg Irs2 Epor Fstl1 Fstl3 Chrdl1 Nup98 Nup37 Nup107 Sec13 Nup160 Nup85 Nup43 Aaas Ranbp2 Nup133 Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Garre1 Shmt2 Akr1c3l1 AABR07032856.1 Akr1c12 Osbpl11 Akr1c1 Nisch Akr1c13 Uaca Nckap1l Wipf3 Wipf1 Itsn2 Akr1c9 Mrtfa Stmn2 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Samm50 Fam169a Amigo2 Noxa1 Baiap2l2 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 P4hb Ralgapa1 Polr2c Chn2 Polr2a Esyt1 Polr2b Trip10 Polr2g Wwp2 Polr2h Fam135a Abi2 Polr2e Abi1 Wdr11 Polr2f Tuba1b Polr2i Msi2 Ppp1r12b Polr2j Stip1 Ppp1r12a Phip Ncbp2 Akap12 Ncbp1 Stk38 Vrk2 Ppp1r14a Abl2 Gtf2f2 Slc1a5 Gtf2f1 Lin7b Cops4 Arpc3 Cops2 Arpc2 Ednrb Ubxn11 Ednra Cpd Sct Arpc5 Rrh Arpc4 Picalm Ptgdr Brk1 Htr4 Ndufs3 Apln Trhr Dsp Tas2r39 Arhgap15 Arhgap17 Htr6 Dsg1 Oprd1 Dsg2 Htr7 Evl Tas2r38 Rhobtb2 C3ar1 Rhobtb1 Crhbp Galr2 Arhgap25 Galr3 Srf Galr1 Arhgap27 Cmklr1 Slitrk5 Slitrk3 Avpr2 Sstr5 Arhgap33 Sstr4 Wasf3 Sstr3 Wasf2 Wasf1 Kel Plekhg1 Sstr2 Ralbp1 Sstr1 Avpr1b Prc1 Rxfp3 Rnf20 Cct6a Avpr1a Cdc42bpa Rxfp1 Cdc42bpb Htr5a Ghrhr Slc4a7 Tbxa2r Arpc1b Gpr183 Actr2 Arpc1a Ppbp Fpr1 Actr3 Btk Gnrh1 Pfn1 Tas1r2 Senp1 Tas1r1 Pfn2 Nmbr Fpr2 Vangl2 Twf1 Ccr10 Tas1r3 Epsti1 C3 Cpne8 Vipr2 Nckap1 Nln Nipsnap2 Vipr1 Ankle2 C5 Cyfip2 Ptgfr Cyfip1 Pnoc Rhoh Tas2r16 Rhof Tas2r13 Rhoc Ppy Rhoj Tas2r135 Rac3 Kif14 Tas2r136 Nmb Rhou Fam13b Oxtr Lpar6 Scai Xcr1 Nckipsd Gpr18 Cct7 Grpr Pak5 Gpr17 Ccdc88a Nms Tmem59 Mtx1 Tas2r140 Nmu Noxo1 Mpp7 Tas2r145 Ankrd26 Cckar Npbwr1 Srgap2 Srgap3 Fshb Ocrl Gpbar1 Tmod3 Nmur2 Cdc42ep1 Gnrhr Adm Cdc42ep4 Nmur1 Plxna1 Ntsr2 Syde1 Ntsr1 Syde2 Tas2r4 Pld2 Ramp1 Elmo2 Rras2 Tas2r3 Dnmbp Brs3 Nsfl1c Ptger4 Ccdc187 Tas2r7 Gabbr1 Plxnd1 Basp1 Ptger2 Ptger3 Ddx4 Spata13 Fshr Kdm4c Gabbr2 Ptger1 Rnd2 Ccr9 Rnd3 Ccr8 Rnd1 Ccr7 Swap70 Arhgdig Ucn2 Mchr1 Baiap2 Kctd13 Ccr6 Ucn3 Fnbp1 Ccr5 Bltp3b Spen Crhr2 Armcx3 Ccr4 Ndufa5 Crhr1 Ccr3 Add3 Gpr132 Tor1aip1 Edn1 Sema4f Edn2 Lmnb1 Edn3 Ptpn13 Cckbr Fmnl2 Fmnl1 Gipr Sh3bp1 Mtnr1b Prag1 Agtr1 Agtr2 Limk1 F2 Vim Gpha2 Hspe1 Gpr37 Tnfaip1 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ghrh Ptgdr2 Rho Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ptgdrl Ccl27 Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Mc3r P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Tas2r40 Fpr2l1 Tas2r41 Cd55 F2rl2 F2rl3 Hcar1 Prokr2 Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb2 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Tacr1 Tacr3 Tacr2 Anxa1 Cxcl11 Nphp4 Hebp1 Calcr Cxcl12 Casr Cxcl10 C5ar2 F2r C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Calcb Chrm1 Calca Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Opn5 Sucnr1 Pyy Adora1 Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Ffar4 Grm8 Ghrl Htr2a Inha Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Inhba Insl3 Inhbb Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Ackr4 Trim27 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb Maf1 Mecom Sall4 Rbfox2 Esrp2 Esrp1 Tbp Tial1 Tia1 Spry2 Gtf2a1 Mknk1 Gtf2a2 Memo1 Ier3 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Rps6kb2 Pik3ap1 Foxo6 Cd28 Syk Icos Sgk1 Nr4a1 Ntf4 Pip5k1a Frk Rictor Cd86 Cd80 Prr5 Bdnf Il1rl1 Trat1 Casp9 Mapkap1 Ntrk2 Rgs20 Rgs17 Rgs16 Gnaz Mtr Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Thbs2 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Fgf17 Fgf18 Pea15 Fgf19 Braf Shoc2 Mark3 Fgf10 Hbegf Mras Artn Lypla1 Gfra1 Ralgdsl1 Gfra2 Gfra4 Rap1a Rap1b Tyk2 Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Il6st Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Ppp3ca Fgf3 Ppp3cb Fgf6 Fgf5 Nfatc1 Fgf8 Fgf7 Fgf9 Ppp3r1 Grap2 Lamtor3 Lamtor2 Tec Hgf Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Il6 Gdnf Pdgfrb Pdgfra Nf1 Il6r Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Wwox Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Aldh1a1 Ccne1 Ptk6 Tfdp2 Tfdp1 Rbl1 E2f4 E2f5 Cdkn1b Rptor RragB Fkbp1a Ppm1a Eif4ebp1 Mtor Stradb Rps6kb1 Rheb Cab39 Strada Pgk1 Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Eef2k Lamtor1 Rragc Rragd Rps6 Stk11 Eif4e Mlst8 Cab39l Pxn Pde5a Pak1 Pak2 Tpm4 Mylk Kat5 Chek1 Kdm4b Cav1 Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Sfn Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Csnk1a1 B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Clip1 Sgo2 Sgo1 Cdc25c Kif2a Kif2b Kif2c Dync1li2 Pmf1 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Ndc80 Ywhaq Ywhah Birc5 Ercc6l Ckap5 Csnk1e Ywhaz Spdl1 Bub1 Itgb3bp Zwilch Pdpk1 Ctnnb1 Sox3 Wnt5a Sox9 Sox7 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Tnks2 Hecw1 Xiap Klhl12 Axin1 Axin2 Rnf43 Tcf7 Dvl1 Dvl2 Dvl3 Sox13 Tcf7l1 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Sox17 Pag1 Fzd8 Bcl9l Bcl9 Cdc73 Rnf146 Cby1 Znrf3 Ctbp1 Amer1 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Wnt8b Smurf2 Wnt8a Sry3 Lef1 Dact1 Sry Nab2 Leo1 Dnal4 Ryk Egr2 Ctnnbip1 Apc Lgr5 Lgr6 Frat2 Pip5k1b Frat1 Plxnb1 Cdh1 Ctnna1 Rack1 Eps15 Jup Ctnnd1 Hsp90ab1 Tbk1 Tax1bp1 Ikbke Cyld Ntrk1 Ngf Plcg1 Arhgef7 Nck2 Rac1 Pak3 Git1 Dhrs4 Pdhx Dhrs3 Aldh1a2 Aldh1a3 Nrip1 Hsp90aa1 Cyp26b1 Pdk4 Pdk3 Dhrs9 Ppid Uhmk1 Pdk2 Sdr16c5 Ppidl1 Pdk1 Nr1h3 Nr1h2 Pdhb Kdm1a Rxrb Rxra Cyp26a1 Sphk1 Zdhhc7 Pgr Rxrg Rdh11 Rdh10 Tbl1x Rdh13 Rdh14 Adh4 Pdha1 Adh1 Pdha2 Greb1 Cited1 Strn Prkcz Cav2 Esr2 Abca1 Cdk9 Crabp1 Crabp2 Igf1r Rdh7 Hdac3 Pou2f1 Tbl1xr1 Rara Foxo3 Mmp7 Mmp2 Mmp3 Zdhhc21 Ppard Fkbp4 Mmp9 Fkbp5 Ptges3 Dld Ncor2 Carm1 Aldh8a1 Gps2 Zfp217 Foxa1 Ncoa3 Rarg Nos3 Fabp5 Yy1 Cyp26c1 Dlat Nr5a2 Notch4 Ngfr Mag Mcf2 Srms Omg Arhgdia Rtn4 Ins1 Lman1 Scfd1 Ins2 Arfgap3 Skil Atp1b4 Stx5 Ykt6 Tmed2 Wwtr1 Stat6 Tgif1 Tgif2 Stat3 Stat1 Trim33 Actg1 Fgfbp3 Fgfbp1 Tiam1 Mcf2l Tiam2 Adam17 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Arhgef10 Arhgef12 Ski Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Psen2 Sos2 Kalrn Ncstn Aph1a Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Myd88 Plekhg2 Net1 Arhgef10l Ap2m1 Gja1 Clta Cltb Myo6 Cltc Socs3 Cbl Foxo1 Septin7 Mapk6 Mapk4 Cdc42ep2 Cdc42ep3 Hspb1 Cdc14b Etv4 Cdc42 Dnajb1 Mapkapk5 Ube2d3 Ube2d2 Acbd5 Aldh3a2 Ide Emd Mapk13 Usp9x Abcd3 Hdac2 Notch3 Ap2s1 Ap2a2 Ap2a1 Gna12 Ap2b1 Numb Sh3gl2 Ncoa2 Eps15l1 Cd19 Sh3gl3 Sh3kbp1 Sh3gl1 Pik3c3 Mtmr4 Pik3r4 Dbt Itga2 Grk3 Epn1 Crk Kidins220 Galnt3 Vamp3 Dtx4 Rhobtb3 Lama4 Ptprz1 Smpd2 Smpd3 Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Pard3 Pard6b Pard6a Lrig1 Amot Tns4 Tns3 Fermt2 Hgfac Hpn Rab4b Flna Gga3 Spint2 Spint1 Ranbp10 Sp1 F11r Pcsk6 Birc2 Ctbp2 Dst Actn1 Megf11 Arhgap32 Farp2 Pip5k1c Ccnc Dzip1 Gpr161 Ihh Gli1 Gli3 Gli2 Shh Kif7 Evc Smo Ulk3 Smurf1 Cdon Dhh Spopl Ptch1 Evc2 Hhip Sufu Hmox2 Sfpq Flot2 Khdrbs1 Flot1 Khdrbs3 Khdrbs2 Tradd Cflar Stub1 Ripk1 Tnfsf10 Fas Cdc37 Fadd Faslg Ube2l3 Ptpn12 Gpc5 Nrp1 Nrp2 Shb Sh2d2a Elmo1 Axl Bcar1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Adam10 Mmp14 Mmp16 Plg Fes Spp1 Timp1 Timp2 Gast Otud7b Stam Snx3 Ar Hif1a Zranb1 Cftr Foxo4 Il33 Nedd8 Fst Usp2 Usp4 Usp7 Usp8 Hgs Smad1 Smad2 Smad3 Smad4 Smad7 Stam2 Otud3 Usp21 Ccp110 Pten Usp13 Flrt1 Flrt3 Flrt2 Arl13b Cct2 Ptk2b Stat5a Stat5b Pde6g Rgs9 Pde6a Pde6b Gnat1 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5685938.1 HDR through Single Strand Annealing (SSA) Rhno1 Mre11 Kat5 Rad51 Rad50 Nbn Rad52 Hus1 Ercc1 Atrip Ercc4 Topbp1 Rbbp8 Rad9a Rpa1 Brca1 Rad9b Rpa2 Bard1 Top3a Rpa3 Rad1 Lig1 Rad17 Rfc5 Rfc3 Rfc4 Rfc2 Atm Atr Exo1 Rmi2 Rmi1 Blm Brip1 Wrn Abl1 Dna2 VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Calm3 Nmt1 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Gngt1 Dhrs3 Apoc2 Apoa1 Gnb1 Apoc3 Apoa2 Apoe Gnb5 Apoa4 Apob Lrp1 Sdc4 Sdc3 Rgs9bp Sdc2 Ppef1 Lpl Pde6g Gpihbp1 Rgs9 Lrp8 Lrp2 Grk1 Lrp10 Grk4 Plb1 Nmt2 Metap1 Lrp12 Metap2 Ttr Camkmt Gpc1 Gucy2e Rdh11 Gpc3 Sag Rdh10 Gpc2 Gucy2f Gpc5 Cnga1 Gpc4 Bco2 Pde6a Bco1 Pde6b Rdh12 Gpc6 Gnat1 Cyp4v2 Clps Rcvrn Stra6 Pnlip Guca1b Rpe65 Akr1b10 Guca1a Rbp4 Rbp3 Myo7a Opn1mw Apom Rbp2 Rlbp1 Rbp1 Sdc1 Lrat Awat2 Opn1sw Rho Agrn Fnta Fntb Cngb1 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%10224783 SHC-mediated cascade:FGFR3 Fgf16 Fgf17 Shc1 Fgf18 Nras Grb2 Kras Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-RNO-9033500.1 TYSND1 cleaves peroxisomal proteins Tysnd1 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%10222789 Transfer of LPS from LBP carrier to CD14 Lbp Cd14 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%10225385 Regulation of Expression and Function of Type II Classical Cadherins Zeb2 Jup Ctnnd1 Ctnnb1 Sp1 Cdh11 Amot Adam19 Angptl4 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224993 MET activates PI3K AKT signaling Hgf Grb2 Pik3ca Met Pik3r1 Gab1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-RNO-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex Bcl11b Smarcc1 Phf10 Smarca4 Arid1a Actl6a Smarcd1 Ss18 Smarce1 Smarcd3 Smarcd2 Dpf2 Actg1 Bcl7a Smarcb1 Bcl7b Bcl7c Bcl11a POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%10223779 Post-transcriptional silencing by small RNAs Ago3 Ago2 Ago1 Tnrc6c Tnrc6a Tnrc6b Ago4 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225171 RHOG GTPase cycle Lman1 Ophn1 Stbd1 Dock2 Vapb Arfgap3 Arhgap35 Mpp7 Vamp3 Cdc42ep1 Plekhg3 Garre1 Itgb1 Shmt2 Ktn1 Elmo2 Arhgap32 Mcf2l Cav1 Arhgdig Pak2 Arhgef16 Pik3r1 Emd Letm1 Ndufa5 Vav3 Dock5 Vav1 Vav2 Dock3 Itsn1 Dock4 Arhgef26 Esyt1 Tfrc Kalrn Hspe1 Iqgap2 Arhgef5 Pak4 Vrk2 Epha2 Stx5 Ykt6 Pgrmc2 Prex1 Map3k11 Ndufs3 Trio Arhgap5 Arhgap1 Dsg2 Rab7a Mcam Pld1 Rhog Arhgdib Diaph3 Depdc1b Lamtor1 Lbr Cdc42 Arhgap21 Mcf2 Ankle2 Arhgdia Cyfip1 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-RNO-8853383.1 Lysosomal oligosaccharide catabolism Man2b1 Man2c1 Manba SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 96%10224253 Synthesis of CL Crls1 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%10224575 HDACs deacetylate histones Hist1h2ai Hmg20b Tbl1x Sap18 Rbbp4 Rbbp7 H2ac18 Suds3 Hdac3 Hist1h2bq Tbl1xr1 Hdac1 Rcor1 Brms1 Hdac2 Ncor2 Hdac10 Hist3h2ba Gps2 Hdac8 Sap30l H2ac4 ENSRNOG00000068602 Chd3 Chd4 H2ac25 Mta1 H2bc18 Mta2 Arid4b Mta3 Arid4a ENSRNOG00000066901 Mbd3 Rest H2bc4 Hist1h4m Kdm1a H2bc1 Gatad2a Gatad2b REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%10223731 Reduction of cytosolic Ca++ levels Slc8a1 Slc8a2 Slc8a3 Atp2b1 Atp2b4 Atp2b3 Calm3 Atp2a1 Atp2a3 Atp2a2 Sri SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%10223305 Signaling by BMP Bmpr2 Cer1 Tgfbr3 Ube2d1 Fstl1 Chrdl1 Bmp2 Ube2d3 Inha Smad1 Smad4 Smad7 Bmpr1a Inhba Bmpr1b Acvrl1 Amh Smurf1 Ski Smad9 Smad5 Smad6 Zfyve16 Acvr2b Gdf2 Acvr2a Bmp10 Amhr2 Smurf2 Grem2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223709 Adrenaline,noradrenaline inhibits insulin secretion Gng7 Adcy5 Gng8 Adcy6 Gngt1 Adra2a Gnb2 Adra2c Gnb1 Gnai2 Gnai1 Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Gng3 Gng5 Gng4 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%10224703 BBSome-mediated cargo-targeting to cilium Sstr3 Tcp1 Arl6 Mchr1 Smo Bbip1 Cct8 Mkks Cct5 Cct4 Bbs2 Ttc8 Lztfl1 Bbs9 Bbs7 Bbs5 Bbs4 Cct3 Cct2 Bbs10 Bbs12 Rab3ip ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10222843 Activation of the AP-1 family of transcription factors Mapk1 Mapk14 Jun Mapk9 Mapk10 Atf2 Mapk11 Fos Mapk3 Mapk8 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 96%10222915 Signaling by TGFB family members Cgn Men1 Nedd8 Fst Ube2d3 Rnf111 Smad1 Smad2 Smad3 Smad4 Mapk3 Smad7 Rhoa Stub1 Usp9x Acvr2a Skil Smurf2 Atp1b4 Tgfbr3 Gipc1 Arrb2 Arrb1 Tgfbr1 Tgfbr2 Ube2m Fgf2 Pard3 Parp1 Inha Pard6a Bmpr1a Inhba Bmpr1b Inhbb Acvrl1 Amh Zfyve9 Smad9 Smad5 Smad6 Wwtr1 Zfyve16 Acvr1c Sp1 Acvr1b Itga8 Acvr2b Gdf2 Itgav Bmp10 Mmp14 Amhr2 Tgfb1 Grem2 Tgfb2 F11r Tgif1 Tgfb3 Tgif2 Mmp16 Bmpr2 Cer1 Ltbp3 Ltbp2 Furin Ltbp4 Ltbp1 Trim33 Ccnk Itgb8 Ccnt2 Itgb6 Itgb1 Bmp2 Itgb3 Hdac1 Timp1 Timp2 Ski Rps27a Psenen Psen1 Psen2 Ncstn Aph1a Ccnc Aph1b Mtmr4 Uba52 Tfdp2 Tfdp1 Ube2d1 Rbl1 Strap Bambi Fstl1 Fstl3 Prkcz Chrdl1 Cdk9 Ubb Ubc E2f4 E2f5 Fkbp1a Ppm1a Ncor2 Smurf1 Cbl Mapk1 GABA SYNTHESIS%REACTOME%R-RNO-888568.1 GABA synthesis Gad1 Gad2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%10222319 Cytochrome P450 - arranged by substrate type Cyp39a1 Cyp2s1 Ncoa2 Cyp8b1 Cyp7b1 Nr1h4 Cyp2w1 Cyp46a1 Cyp27a1 Cyp2c24 Cyp7a1 Cyp2u1 Pomc Arnt2 Arnt Ahrr Ahr Cyp11a1 Fdx2 Fdxr Cyp26b1 Cyp11b1 Cyp11b2 Cyp19a1 Rxra Cyp26a1 Cyp24a1 Cyp3a9 Cyp27b1 Cyp1b1 Fdx1 Cyp3a18 Cyp4v2 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Tbxas1 Cyp3a1 Cyp1a2 Cyp2d4 Ptgis Cyp3a62 Cyp3a2 Cyp2j16 Adh7 Cyp4f39 Cyp21 Cyp2j3 Cyp11b3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp26c1 Cyp4b1 Cyp2a2 Cyp2a1 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 RAC2 GTPASE CYCLE%REACTOME%R-RNO-9013404.1 RAC2 GTPase cycle Lman1 Ophn1 Stbd1 Dock2 Def6 Vapb Mtx1 Arhgap35 Mpp7 Cyba Vamp3 Cybb Racgap1 Cdc42ep1 Garre1 Cdc42ep4 Itgb1 Syde1 Pld2 Nckap1l Arhgap42 Pik3ca Tiam1 Arhgap32 Pak1 Cav1 Swap70 Git1 Samm50 Pak2 Pik3r1 Emd Baiap2l1 Armcx3 Vav3 Pik3r2 Pik3r3 Vav1 Taok3 Vav2 Dock3 Dock4 Esyt1 Tfrc Abi2 Abi1 Pak4 Vrk2 Git2 Epha2 Ncf1 Abr Dock10 Ncf2 Ncf4 Pgrmc2 Brk1 Prex1 Bcr Trio Arhgap17 Arhgap1 Dsg2 Rab7a Mcam Slitrk5 Wasf2 Rac2 Diaph3 Depdc1b Lamtor1 Lbr Cdc42 Arhgap21 Nckap1 Mcf2 Arhgap26 Ankle2 Arhgdia Cyfip1 SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies Hmgcl Acss3 Bdh2 Bdh1 Hmgcll1 Acat1 Hmgcs2 Aacs THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor Gng7 Gng8 Gngt1 Gna13 Gnb2 Gnb1 Tbxa2r Gnb4 Gnb3 Gna11 Gnb5 Gng11 Aamp Gna14 Gng10-ps1 Gng3 Gng5 Gng4 Gnaq SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%10222547 SMAC (DIABLO) binds to IAPs Casp7 Diablol1 Xiap REGULATION OF PYRUVATE METABOLISM%REACTOME%R-RNO-9861718.1 Regulation of pyruvate metabolism Pdp1 Pdpr Pdp2 Uba52 Pkml1 Pdha1 Pdha2 Ranbp9 Wdr26 Nek1 Ubb Mkln1 Ubc Gid4 Maea Ldha Armc8 Me1 Rmnd5b Dld Pdhx Pgam5 Rps27a Pdk4 Pdk3 Dlat Pdk2 Pdk1 Pdhb Gstz1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 96%10222111 Cellular response to chemical stress Keap1 Cox5a Cox5b Fabp1 Ufd1 Blvrb Gsk3b Map1lc3b Hmox2 Blvra Abcc1 Hmox1 Higd1c Mul1 Alb Gstp1 Cox4i1 Cox4i2 Sesn2 Sesn1 Nploc4 P4hb Cox7a1 Cox7a2 Cat Cox7a2l Ncf1 Hba1 Ncf2 Hbb Ncf4 Txn Cycsl2 Cycs Gpx2 Sod2 Gpx1 Ncoa2 Crebbp Ndufa4 Ppara Cyba Sin3a Cybb Sin3b Prdx2 Prdx5 Srxn1 Prdx1 Nfe2l2 Sod1 Prkci Txnrd1 Psma4 Akt3 Psma3 Akt2 Sqstm1 Akt1 Psma6 Ep300 Psma5 Psma2 Gsr Psma1 Rps27a Psmd12 Psmd11 Smarcd3 Cox6a1 Psmd14 Cox6a2 Psmd13 Txn2 Bach1 Med1 Skp1 Psmb5 Psmb4 Rxra Cox6c2 Psmb7 Trim21 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Tbl1x Btrc Psma7 Cox6b1 Prdx3 Cox6b2 Psmc5 Prdx6 Psmc2 Psmc1 Psmc4 Psmc3 Nox4 Hdac3 Gpx3 Ubb Gpx6 Tbl1xr1 Gpx5 Ubc Gpx8 Gpx7 Psmb6l1 Psmd7 Hm13 Psmd6 Psmd8 Mt-co3 Psmd2 Prkaa2 Mt-co2 Ncor2 Nudt2 Psmd1 Cox8a Carm1 Ubxn7 Adrm1 Rbx1 Cul1 Tgs1 Cox8c Ero1a Vcp Cox7b Txnrd2 Cox7c Mt-co1 Sod3 Ccs Cul3 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10223125 Membrane Trafficking Ereg Btc Galnt1 Galnt2 Spta1 Sptb Sptbn1 Sptbn2 Hbegf Sptan1 Sptbn5 Sptbn4 Grb2 Vamp2 App Tgfa Areg Tjp1 Il7r Egfr Chmp2b Chmp3 Kif4b Chmp7 Ap2s1 Chmp6 Kif4a Vps4a Chmp4c Dnm3 Ap2a2 Chmp4bl1 Ap2a1 Ap2b1 Sh3gl2 Alpi Cyth2 Cyth3 Cyth4 Vps36 Cyth1 Slc18a3 Bnip1 Egf Vps25 Vps28 Bin1 Synj1 Bloc1s3 Kif18b Bloc1s4 Kif19 Bloc1s6 Kif26b Snf8 Kifc1 Snap29 Kifc2 Snx18 Kif26a Ubap1 Ston1 Ston2 Eps15l1 Kif11 ENSRNOG00000062839 Kif12 Tor1a Tor1b Kif15 Nbas Rab36 Kif5a Kif5b Rab3il1 Tpd52 Kif21a Madd Scarb2 Kif1c Akt3 Ldlr Akt2 Snapin Kif21b Akt1 Kif13b Cops3 Kif1a Sbf2 Cops6 Kif1b Sbf1 Optn Cops8 Kif6 Rab11b Aak1 Rab11a Synj2 Rab31 Tbc1d8b Rab35 Syt11 Tf Kif9 Rab38 Sh3gl3 Tsc2 Sh3kbp1 Tsc1 Tfrc Rab3gap2 Tpd52l1 Rab3gap1 Vps4b Dennd1a Dtnbp1 Kif22 Dnajc6 Clvs1 Rab1b Sh3gl1 Kif23 Dnase2 Fnbp1l Ulk1 Clvs2 Dennd1b Rint1 Kif28 Trappc2l Pik3c2a Fth1-ps5 Kif27 Ap4b1 Dennd1c Bicd2 Ap1b1 Kif16b Chmp2a Bicd1 Rin3 Kif20a Gabarap Klc1 Ap1m2 Agpat3 Vamp7 Fcho1 Rin1 Kif20b Bloc1s1 Fcho2 Rin2 Ap1m1 Pafah1b3 Mon1b Kifap3 Vamp8 Pafah1b2 Dennd6a Ap4s1 Fth1 Mon1a Ap1s3 Klc4 Mvb12a Dennd6b Ap1s2 Rab5a Mvb12b Rab4a Klc3 Necap2 Txndc5 Trappc10 Klc2 Necap1 Ap1g2 Vps37a Ap1g1 Rabgap1 Rab33b Vps37b Ap4m1 Rab33a Vps37c Kif3b Hspa8 Tbc1d2 Vps37d Ap4e1 Hps1 Hip1r Tbc1d7 Agfg1 Kif3c Gabarapl2 Vps45 Snx2 Snx9 Ccz1 Hps4 Snx5 Trappc12 Pum1 Trappc11 Cops7a Trappc13 Cops7b Rab3a Hip1 Rinl Tsg101 Gapvd1 Ftl1 Als2cl Gak Gdi1 Stx18 Rabgef1 Yipf6 Gdi2 Chm Pla2g6 Rab7a Pacsin1 Rab7b Pacsin3 Pacsin2 Dennd4c Sort1 Dennd4a Ap3b1 Dennd4b Sh3d19 Ywhae Rab27a Grk3 Rab39a Amph Tbc1d14 Snap91 Rab27b Syt2 Tbc1d13 Syt9 Tbc1d16 Acbd3 Tbc1d15 Syt8 Tbc1d17 Use1 Trappc6b Akp3 Trappc6a Alpp Trappc9 Alpg Trappc8 Ubqln2 Tbc1d10c Chmp5 Trappc5 Ubqln1 Trappc4 Epn2 Trappc3 Epn1 Dennd5a Reps1 Trappc2 Reps2 Tbc1d10b Trappc1 Rab6b Tbc1d10a Rab6a Rab5c Rab5b Dennd5b Stx4 Als2 Golga4 Rab3ip Sytl1 Rab43 Tbc1d25 Tmf1 Tbc1d24 Sys1 Arf6 Golga1 Map1lc3b Vps51 Rab21 Vps52 Chml Vps54 Arl1 Rab9a Gcc2 Rab9b Gcc1 Dennd2a Rab1A Usp6nl Stx6 Dennd2c Ric1 Ttgn1 Rab10 Igf2r Scoc Rab13 M6pr Rab12 Vti1a Rab14 Vamp3 Rab18 Vamp4 Rab8b Stx16 Rab8a Arfip2 Rgp1 Rhobtb3 Ankrd27 Rabepk Dennd3 Arfrp1 Snap23 Slc2a8 Src Gria1 Arrb2 Arrb1 Cd3g Cd3d Cd4 Ctsz Pip5k1c Pafah1b1 Zw10 Kif18a Dync1h1 Dync1i2 Dync1i1 Cenpe Sec13 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Dynll1 Dynll2 Wnt5a Kif3a Itsn2 Dvl2 Fzd4 Sar1b Gps1 Apob Trip10 Lrp2 Cops4 Arpc3 Cops2 Arpc2 Cpd Arpc5 Arpc4 Picalm Eps15 Dnm2 Avpr2 Trip11 Actr2 Arpc1a Actr3 Gns Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Racgap1 Ocrl Fnbp1 Rps27a Agtr1 Ldlrap1 Uba52 Avp Ubb Ubc Pla2g4a Stam Cftr Ins1 Cd55 Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Adrb2 Cog6 Cog7 Nedd8 Cog8 Napa Nsf Napb Ank1 Grk2 Napg Sec23a Tmem115 Tacr1 Kdelr2 Kdelr3 Sec23ip Sec16b Hgs Sec16a Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Stam2 Tmed10 Tmed9 Copb1 Cope Golgb1 Chrm2 Col7a1 Ppp6c Sec31b Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Syt1 Itsn1 Ap2m1 Gja1 Clta Cltb Myo6 Cltc Dab2 Dnm1 Cbl Cops5 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%10224925 Regulation of the apoptosome activity Mapk1 Apip Cycsl2 Diablol1 Casp9 Apaf1 Cycs Xiap Mapk3 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-RNO-351906.1 Apoptotic cleavage of cell adhesion proteins Cdh1 Tjp2 Dsp Ocln Casp3 Tjp1 Dsg1 Dsg2 Ctnnb1 Pkp1 Dsg3 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-RNO-9768919.1 NPAS4 regulates expression of target genes Maged1 Npas4 Arnt2 Bmal1 Arnt BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 96%10225217 Biosynthesis of maresins Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a9 Cyp3a62 Cyp3a2 Alox5 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%10222567 Coagulation pathway Fgb F10 Procr Fga F12 F11 Fgg Itga2b Proc Klkb1 F13a1 Serpine2 Serping1 Itgb3 Proz Serpina10 Cd177 F2r Kng1 App Serpina5 Sdc4 Sdc3 F2 F8 Sdc2 Serpind1 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Thbd Smpd1 Gpc6 Pros1 Serpinc1 Sdc1 Tfpi Pf4 Agrn Gp5 Gp9 Gp1bb F13b Serpine1 Gp1ba Ano6 Ano5 F3 F7 F9 Prtn3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-RNO-1268020.1 Mitochondrial protein import Hscb Fxn Ndufb8 Coq2 Atp5mc3 Pitrm1 Ldhd Otc Atp5f1b Hspd1 NURD COMPLEX ASSEMBLY%REACTOME%R-RNO-9937850.1 NuRD complex assembly Hist1h2ai Ube2i Rbbp4 Rbbp7 H2ac18 Hist1h2bq Hdac1 Hdac2 H2aj Nr2c2 H2ab2 Zmynd8 Ikzf3 Ikzf1 Zfp827 H3-3b Zfp532 Hist3h2ba H2ac4 ENSRNOG00000068602 Phf6 Chd3 Zfp592 Chd4 Cdk2ap1 Mbd2 Nr2f2 Mta1 H2bc18 Chd5 Mta2 Mta3 Tcf19 ENSRNOG00000066901 Mbd3 H2az2 Pwwp2a H2bc4 Mbd3l1 Hist1h4m Mbd3l2 Sumo1 H2bc1 Zfp687 Gatad2a Gatad2b TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10223999 Transport of fatty acids Slc27a4 Slc27a6 Lcn12 Vegp2 Vegp1 Lcn9 Apod Slc27a1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 96%10223209 Degradation of beta-catenin by the destruction complex Ppp2cb Ppp2ca Gsk3b Ctnnb1 Ctbp2 Tle4 Tle3 Tle2 Tle1 Ppp2r5d Axin1 Tcf7 Tcf7l1 Tcf7l2 Ppp2r1b Psma4 Ppp2r1a Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ctbp1 Amer1 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ppp2r5b Lef1 Ppp2r5a Psmb1 Psmb3 Psmb2 Uba52 Apc Frat2 Btrc Psma7 Frat1 Csnk1a1 Ppp2r5e Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Zranb1 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 96%10223621 Protein-protein interactions at synapses Shank1 Shank3 Homer1 Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Epb41l2 Epb41l3 Epb41l5 Lrrtm1 Lrrtm2 Lrrtm3 Lrrtm4 Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Sh3glb2 Nlgn3 Lrrc4b Il1rapl1 Ptprf Il1rapl2 Il1rap Slitrk6 Slitrk4 Slitrk1 Slitrk2 Ppfibp2 Ppfibp1 Flot2 Flot1 Ntrk3 Grin2a Gria4 Gria3 Dlg1 Dlg2 Gria1 Dlg3 Dlg4 Grin1 Grin2d Grin2c Grin2b Cask Grm1 Grm5 Slitrk5 Slitrk3 Ppfia3 Ppfia2 Ppfia4 Lrfn2 Rtn3 Ppfia1 Epb41l1 Lrfn3 Lrfn4 Lrfn1 Ptprs BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins Alox5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10222571 Extracellular matrix organization Adamts3 Adamts2 Fn1 Col4a1 Col4a2 Nid2 Adamts14 P4hb Sdc4 Sdc3 Sdc2 Ctsb Ctss Cdh1 Sdc1 Fgf2 Gpr162 Col14a1 Col10a1 Ppib Col1a2 Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Col24a1 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 Mmp24 P3h1 Mmp25 Crtap Col18a1 Pcolce2 Adam15 Colgalt2 Optc Col2a1 Adam10 Col27a1 Bsg Col6a2 Htra1 Serpinh1 Col23a1 ENSRNOG00000069479 Mmp20 Col6a5 Mmp11 Col6a6 Eln Col26a1 Col4a5 Mmp12 Itga8 Col6a3 Col8a1 Mmp13 Itgav Mmp14 Col4a6 Bmp10 Col8a2 Adamts5 Vtn Mmp15 Tgfb1 Lum Plod3 Adamts4 Tgfb2 Plod1 Mmp16 Tgfb3 Plod2 Mmp17 Loxl2 Fgb Ltbp3 Mmp19 Bmp1 Fga Ltbp2 Adam8 Loxl1 Fgg Mmp8 Try10 Furin Acan Ltbp4 Prss2l1 Itga2b Ctrb1 Fbln2 Mmp10 Loxl4 Ltbp1 Cast Loxl3 Col15a1 Fbln5 Capn15 Efemp2 Col13a1 Plg Mfap4 Klkb1 Mfap5 Col19a1 Mfap2 Phykpl Itgb8 Spp1 Itgb6 Bmp7 Try5 Gdf5 Cd44 Bmp4 LOC102554637 Capn9 Itgb1 Scube3 Bmp2 Lox Capn8 Scube1 Itgb3 Capn5 Fbn1 Capn7 Capn6 Ddr2 Col25a1 Adam12 Capn1 Ddr1 Timp1 Capn3 Capn2 Timp2 Prss2 Prss3 Tmprss6 Elane Mmp1b Tpsb2 Prss1 Spock3 Capns1 Capn10 A2m Capn11 Capn12 Capn13 Tnc Itga7 Itgax Dmp1 Itga9 Dspp Mmp7 Bcan Mmp2 Vcan Mmp3 Tnn Itga2 Tnr Agrn Mmp9 Tnxb Ncan Dcn Hapln1 Serpine1 Ceacam1 Jam3 Jam2 Prkca Itga3 Itga4 Sntg2 Dtna Dtnb Itga1 Sgcz Snta1 Sntb2 Sntb1 Drp2 Sgce Sgcd Utrn Sgcb Sgca Lama4 Itgal Sspn Dmd Sgcg Col7a1 Itgb2 Tll2 Tll1 Thbs1 Pxdn Ctsd Cd47 Ctsg Itga6 Cma1 F11r Dag1 Adam19 Ctsk Ctsl Pecam1 Itgb4 Megf11 Madcam1 Comp Itgae Itgad Itgb7 Icam1 Icam5 Icam4 Icam2 Itga10 Col4a4 Vcam1 Ibsp MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%10222081 Mitochondrial Fatty Acid Beta-Oxidation Hadha Acadvl Hadhb Acadl Echs1 Pctp Hadh Acads Ndufab1 Eci1 Acadm Decr1 Mmut Mecr Mcat Them4 Acad11 Pcca Acaa2 Pccb Acbd6 Acot1 Acsf2 Dbi Acot2 Acot11 Acot12 Acot5 Acot13 Them5 Acot3 Acot9 Acot7 Mmaa INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling Lifr Crlf1 Jak2 Stat3 Stat1 Il6 Cntf Cntfr Socs3 Clcf1 Cbl Ctf1 Il6r Il31ra Lif Il11 Tyk2 Ptpn11 Osmr Il11ra1 Il6st Osm VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-RNO-196843.1 Vitamin B2 (riboflavin) metabolism Slc52a2 Slc52a3 Rfk Acp5 Flad1 Enpp1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production Dhx36 Dhx9 Nfkb2 Nfkb1 Myd88 Irf7 Rela DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%10224571 Degradation of AXIN Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Tnks2 Ubb Axin1 Axin2 Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Rnf146 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Tnks Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-RNO-72649.1 Translation initiation complex formation Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Pabpc1 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Rps6 Eif4e RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10224737 RHO GTPase cycle Mtr Frs2 Frs3 Acbd5 Sptbn1 Aldh3a2 Sptan1 Emd Grb2 Rbmx Sos1 Tra2b Usp9x Iqgap2 Abcd3 Map3k11 Rasgrf2 Rasal2 Csk Itgb1 Atp6ap1 Dock5 Dock6 Steap3 Dock3 Dock4 Dock7 Tfrc Dock8 Dbt Dock10 Dock11 Rab7a Lamtor1 Lbr Kidins220 Als2 Gopc Rhoq Vamp3 Sh3rf1 Ckb Snap23 Pde5a Pak1 Pak2 Tpm4 Rhoa Ngef Ncf1 Zap70 Ncf2 Ncf4 Lck AABR07021573.2 Rhog Rhob Pard6b Pard6a Rac2 Fermt2 Cyba Cybb Dst Actn1 Pik3ca Arhgap32 Cav1 Farp2 Pik3r1 Pik3r2 Pik3r3 Nudc Rbbp6 Aaas Hmox2 Garre1 Shmt2 AABR07032856.1 Osbpl11 Nisch Uaca Nckap1l Itsn2 Stmn2 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Flot2 Samm50 Flot1 Fam169a Amigo2 Noxa1 Baiap2l2 Rapgef1 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 Ralgapa1 Cdc37 Chn2 Esyt1 Trip10 Wwp2 Fam135a Abi2 Abi1 Wdr11 Tuba1b Msi2 Stip1 Cpsf7 Phip Akap12 Stk38 Vrk2 Abl2 Slc1a5 Cops4 Cops2 Srgap1 Ubxn11 Arhgap45 Slk Cpd Cavin1 Daam1 Pgrmc2 Picalm Tex2 Brk1 Bcr Ndufs3 Arhgap6 Jup Dsp Arhgap5 Arhgap15 Arhgap4 Arhgap17 Dsg1 Sowahc Arhgap1 Dsg2 Stom Arap1 Rhobtb2 Arap3 Rhobtb1 Arap2 Arhgap25 Arhgap9 Arhgap8 Arhgap27 Mcam Slitrk5 Slitrk3 Pld1 Arhgap33 Ccdc115 Wasf3 Rtkn Wasf2 Rhpn1 Hsp90ab1 Wasf1 Rhpn2 Stk10 Plekhg1 Ralbp1 Stard8 Maco1 Rnf20 Ddrgk1 Cct6a Faf2 Cdc42bpa Arhgdib Gmip Cdc42bpb Slc4a7 Anln Arhgap10 Iqgap3 Diaph3 Diaph1 Arhgap19 Arhgap18 Depdc1b Senp1 Cit Vangl2 Fam13a Arhgef28 Twf1 Epsti1 C1qbp Arhgap22 Cpne8 Arhgap21 Nckap1 Arhgap20 Nipsnap2 Arhgap26 Ankle2 Arhgap24 Cyfip2 Arhgap23 Cyfip1 Arhgap29 Rhoh Arhgap28 Rhof Rhoc Ophn1 Rhoj Stbd1 Rac3 Dock2 Def6 Kif14 Vapb Rhou Pcdh7 Fam13b Myo9b Emc3 Arhgap11a Cct7 Pak5 Myo9a Arhgap31 Ccdc88a Arhgap30 Tmem59 Prex2 Mtx1 Noxo1 Actc1 Arhgap35 Mpp7 Ankrd26 Fmnl3 Tagap Srgap2 Racgap1 Srgap3 Plekhg6 Ocrl Tmod3 Tmem87a Plekhg3 Cdc42ep1 Bcap31 Cdc42ep4 Ktn1 Plxna1 Farp1 Syde1 Dlc1 Syde2 Pld2 Stard13 Arhgap40 Elmo2 Pkn2 Rras2 Rock2 Arhgef7 Dnmbp Rock1 Nsfl1c Pkn1 Ccdc187 Arhgap44 Plxnd1 Arhgap42 Basp1 Tjp2 Ddx4 Spata13 Nck2 Rnd2 Rac1 Rnd3 Pak3 Rnd1 Git1 Swap70 Arhgdig Baiap2 Kctd13 Fnbp1 Bltp3b Spen Hsp90aa1 Armcx3 Ndufa5 Add3 Tor1aip1 Sema4f Lmnb1 Ptpn13 Fmnl2 Fmnl1 Sh3bp1 Prag1 Vim Hspe1 Tnfaip1 Nck1 Actb Stam Mcf2 Arhgdia Cftr Lman1 Scfd1 Grb7 Arfgap3 Hgs Stam2 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Ccp110 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Stx5 Ykt6 Ckap4 Arl13b Cct2 Actg1 Ptk2b Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Gja1 Ddx39b Myo6 Cltc Vcp Hnrnpc Cdc42ep2 Cdc42ep3 Cdc42 Cul3 Srrm1 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 96%10225459 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Mphosph8 Hist1h2ai H2aj Atf7ip H2ab2 H3-3b Hist3h2ba H2ac4 Tasor H2ac18 ENSRNOG00000068602 Setdb1 Pphln1 Morc2 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9037629.1 Lewis blood group biosynthesis St3gal6 St3gal4 B3galt1 St3gal3 Fut2 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 St6galnac6 MITOTIC G2-G2 M PHASES%REACTOME%R-RNO-453274.1 Mitotic G2-G2 M phases Ywhag Actr1a Ppp2cb Ppp2ca Gtse1 Dctn1 Dctn2 Prkaca Rab8a Akap9 Phlda1 Ofd1 Prkar2b Ppp2r1b Ppp2r1a Ppp1r12b Ppp1r12a Csnk1d Ccp110 Fbxw11 Ppp1cb Nedd1 Mzt2b Tpx2 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Tp53 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Nme7 Hsp90ab1 Cep152 Tuba4a Tubgcp2 Haus4 Haus5 Haus6 Pcnt Ccnh Sfi1 Haus1 Fkbpl Tubgcp6 Tubgcp5 Tubgcp4 Tubgcp3 Cep250 Cep290 Bora Cep78 Cep76 Foxm1 Cep72 Ppme1 Lcmt1 Cep164 Cep70 Mis18bp1 Hjurp Cpap Cdc25b Tubb5 Obi1 Plk4 Odf2 Ticrr Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Cdk7 Fbxl7 Mnat1 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Hsp90aa1 Optn Psma2 Psma1 Rps27a Psmd12 Ppp2r3b Psmd11 Pafah1b1 Psmd14 Cdc25a Psmd13 Ccnb2-ps2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ppp2r2a Dync1h1 Ccnb1 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Dync1i2 Btrc Psma7 Aurka Ajuba Psmc5 Psmc2 Psmc1 Nde1 Psmc4 Psmc3 Wee1 Fzr1 Ubb E2f1 Ubc Nek2l1 E2f3 Psmb6l1 Clasp1 Psmd7 Ywhae Psmd6 Pkmyt1 Psmd8 Plk1 Psmd2 Sgo1 Cdc25c Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdk1 Mapre1 Dynll1 Ccnb2 Ckap5 Csnk1e SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-RNO-399954.1 Sema3A PAK dependent Axon repulsion Hsp90ab1 Plxna4 Pak1 Rac1 Plxna3 Pak3 Plxna2 Pak2 Hsp90aa1 Sema3a Fes Fyn Nrp1 Plxna1 Limk1 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222605 Activation of NOXA and translocation to mitochondria Pmaip1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 96%10222077 Citric acid cycle (TCA cycle) Nfs1 Fxn Sirt3 AC132020.1 Ogdh Dlst Lyrm4 Kgd4 Suclg1 Suclg2 Isca2 Isca1 Dld Trap1 Sdhaf1 Mdh2 Sdhaf2 Sdhaf3 Cs Nnt Idh2 Fh Sdhd Sdhc Sdhb Sdha Iscu Acat1 Aco2 Idh3B Idh3g Sucla2 Idh3a NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223521 Netrin-1 signaling Dscaml1 Ntn4 Dscam Unc5a Rac1 Dcc Prkcq Ptk2 Nck1 Src Fyn Trio Cdc42 Ezr PKR-MEDIATED SIGNALING%REACTOME%R-RNO-9833482.1 PKR-mediated signaling Ppp2cb Ppp2ca Stat3 Stat1 Hspa1b Ube2l6 Hspa1a Ppp2r1b Ppp2r1a Ikbkb Dnajc3 Eif2ak2 Ikbkg Sphk1 Ppp2r5a Fancl Fancm Fanca Fancb Fancc Mapt Fance Fancf Fancg Nck1 Hspa8 Prkra Ilf2 Dus2 Ilf3 Tarbp2 Snca Dhx9 Arih1 Trim25 Ptpn2 Map2k6 Hspa1l Tp53 Faap100 Npm1 Hspa2 Faap24 Isg15 Faap20 Mavs Cdk1 Adar Chuk ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222945 Alternative complement activation C3 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%10223567 Enzymatic degradation of Dopamine by monoamine oxidase Maoa Comt SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%10224781 SHC-mediated cascade:FGFR1 Fgf17 Shc1 Fgf10 Nras Grb2 Kras Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Hsd3b7 Ncoa2 Akr1d1 Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Akr1c19 Nr1h4 Akr1c21 Cyp27a1 Cyp7a1 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Rxra Akr1c9 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly Nup133 Nup210 Nup155 Nup153 Ddx20 Snrpepl2 Wdr77 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 Snrpg Gemin5 Snrpb Nup58 Gemin8 Nup37 Pom121 Prmt5 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Smn1 Nup160 Rae1 Snupn Ndc1 Snrpd1 Clns1a Nup85 Nup42 Nup62 Nup43 Nup88 Gemin7l1 Aaas Snrpd3 Ranbp2 Nup214 Gemin2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%10222823 Toll Like Receptor 9 (TLR9) Cascade Ppp2cb Ppp2ca Tasl Eea1 Irf5 Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Slc15a4 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Rbsn Tlr9 Rps27a Skp1 Pik3c3 Uba52 Pik3r4 Btrc Ubb Ubc Cul1 Mapk1 Ly96 Ticam2 Irf7 Ticam1 Cd14 Tlr4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf5 Fgf8 Fgfr3 Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Gab1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade Grk4 Nmt2 Metap1 Metap2 Camkmt Gucy2e Sag Gucy2f Cnga1 Pde6a Pde6b Gnat1 Rcvrn Guca1b Guca1a Calm3 Nmt1 Rho Gngt1 Gnb5 Fnta Fntb Rgs9bp Ppef1 Pde6g Rgs9 Grk1 Cngb1 TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling Birc2 Mib2 Otulin Ube2d3 Usp2 Ube2d2 Xiap Usp4 Adam17 Madd Tradd Cflar Optn Stub1 Ripk1 Rps27a Fadd Rbck1 Ube2l3 Ikbkb Ulk1 Usp21 Ikbkg Map3k7 Uba52 Smpd2 Smpd3 Traf2 Ube2d1 Sharpin Tnf Otud1 Tnfrsf1a Traf1 Spata2 Rnf31 Rack1 Clip3 Sppl2b Ubb Sppl2a Ubc Casp8 Tbk1 Mapkapk2 Tax1bp1 Ikbke Cyld Nsmaf Tab3 Otud7b Tab2 Tab1 Chuk CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%10223737 cGMP effects Pde5a Pde11a Irag1 Itpr1 Pde10a Pde2a Pde1b Prkg1 Prkg2 Pde9a Pde1a REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%10225399 Regulation of Expression and Function of Type I Classical Cadherins Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Src Fyn Ctbp1 Ctsb Cbll1 Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Vcl Hdac2 H2ab2 Twist1 Kmt5a H2ac4 Sec11c Sec11a Prkcsh Sirt1 Zmym2 ENSRNOG00000066901 Pomt1 Dnttip1 Pomt2 Furin Pcsk7 Pcsk6 H2ac18 Ctbp2 Csnk2a2 Ctsl Zeb1 Csnk2a1 Hist1h2bq Hdac1 Ganab Csnk2b Mphosph8 H2aj Canx Arhgap32 Spcs3 Spcs1 Spcs2 Psma4 Smarca4 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Ezh2 Dad1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) Nab2 Ppp2cb Ppp2ca Egr2 Vrk3 Sgk1 Rps6ka3 Rps6ka1 Rps6ka2 Ppp2r5d Dusp3 Srf Dusp4 Dusp7 Creb1 Dusp6 Mapk14 Ppp2r1b Mapkapk2 Ppp2r1a Mapk3 Rps6ka5 Mapk1 Chd4 Mapk11 Atf1 Mapk7 PROTEASOME ASSEMBLY%REACTOME%R-RNO-9907900.1 Proteasome assembly Psmb6 Psmb1 Psmb3 Psmb2 Psme2 Psme1 Psma7 Psmb9 Psmb10 Psmb8 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmb6l1 Psmd7 Psmd6 Psmg1 Psmd8 Psmg4 Psmg3 Psmd2 Psma4 Psmd10 Pomp Psmd1 Psma3 Psmd5 Adrm1 Psmd4 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-RNO-163358.1 PKA-mediated phosphorylation of key metabolic factors Mlxipl MITOPHAGY%REACTOME%R-RNO-5205647.1 Mitophagy Map1lc3b Ube2n Uba52 Csnk2a2 Csnk2a1 Ube2d3 Ube2d2 Ubb Ubc Csnk2b Mfn1 Mfn2 Tomm22 Tomm20 Atg5 Tbk1 Atg12 Vdac2 Atg9a Sqstm1 Vdac3 Src Pgam5 Vdac1 Tomm40 Prkn Optn Tomm70 Rps27a Mterf3 Map1lc3a Pink1 Fundc1 Ube2l3 Tomm7 Ulk1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 96%10222489 Glucagon signaling in metabolic regulation Gcgr Prkar1a Prkar2a Prkar1b Prkar2b Prkaca Prkacb Gcg SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223807 SLC-mediated bile acid transport Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Slc5a7 Slc10a6 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%10222225 Insulin receptor recycling Ins2 Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Ptprf Atp6ap1 Insr Ptpn1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Ide Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Ctsd Ins1 METABOLISM OF STEROIDS%REACTOME%R-RNO-8957322.1 Metabolism of steroids Hmgcr Mvd Msmo1 Srebf1 Amacr Akr1c18 Akr1c12l1 Akr1c19 Hsd3b Hsd17b3 Akr1c21 Cyp17a1 Gc Hsd3b6 Scp2 Hsd3b5 Srd5a3 Hsd11b1 Hsd3b1 Hsd11b2 Srd5a1 Hsd17b12 Acox2 Srd5a2 Hsd3b5-ps1 Serpina6 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Pomc Hsd17b4 Akr1c9 Slc27a2 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Acot8 Lrp2 Pias4 Ube2i Baat Lhb Cga Akr1b10 Sts Kpnb1 Tspoap1 Cyp21 Cyp11b3 Ch25h Ran Osbpl3 Osbpl2 Osbpl1a Osbpl7 Osbpl6 Lgmn Cyp39a1 Sumo3 Osbpl9 Hsd3b7 Ncoa2 Vdr Akr1d1 Cyp8b1 Cyp7b1 Slc10a1 Fabp6 Nr1h4 Abcc3 Stard5 Cyp46a1 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Slc51b Abcb11 Akr1b1 Stard4 Star Stard6 Cyp11a1 Tspo Fdx2 Fdxr Cyp11b1 Cyp11b2 Cyp19a1 Rxra Ldlrap1 Cyp24a1 Cyp27b1 Scap Fdx1 Mbtps1 Cubn Fdps Plpp6 Idi1 Hsd17b7 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Lbr Acat2 Nsdhl Dhcr24 Dhcr7 Lss Slco1a4 Tm7sf2 Srebf2 Slco1b2 Pmvk INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling Il18bp Il18 Il18rap Il18r1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%10225301 Activation of RAC1 downstream of NMDARs Camk1 Calm3 Camkk1 Camkk2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-RNO-73856.1 RNA Polymerase II Transcription Termination Cpsf7 Cpsf1 Ncbp2 Cpsf2 Ncbp1 Cpsf3 Snrpepl2 Snrpf Slbp Snrpg Snrpb Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Cstf2 Cstf3 Cstf2t Lsm10 Lsm11 Sympk Pabpn1 Snrpd3 Clp1 Cpsf4 Cpsf6 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223173 Glucocorticoid biosynthesis Hsd3b Cyp17a1 Hsd3b6 Cyp21 Hsd3b5 Cyp11b3 Hsd11b1 Hsd3b1 Hsd11b2 Hsd3b5-ps1 Serpina6 Pomc Cyp11b1 Cyp11b2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%10222503 PKA-mediated phosphorylation of CREB Adcy5 Adcy6 Adcy9 Prkar2a Prkar2b Prkaca Prkacb Prkar1a Prkar1b Calm3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225415 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Ncoa2 Crebbp H2ac18 Hist1h2bq H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 H2bc18 Med27 Med12 Med1 H2az2 Med13 H2bc4 Med14 Hist1h4m H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Paxip1 Pparg Med6 Med16 Tbl1x Med17 Ajuba Pagr1 Med30 Med31 Ppargc1a Ppargc1b Hdac3 Tbl1xr1 Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Abl1 ENSRNOG00000066901 THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome Nlrp3 Txn Mefv Pstpip1 Hsp90ab1 P2rx7 Pycard Panx1 Txnip Sugt1 G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation Gng7 Gng8 Gngt1 Gnb2 Oprm1 Gnb1 Gnb4 Gnb3 Gna11 Gnb5 Gng11 Pdyn Gna14 Gng10-ps1 Gng3 Pomc Gng5 Gng4 Gnaq GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Gng3 Gnal Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Gnat3 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225451 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes Ncoa2 Crebbp H2ac18 Hist1h2bq H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 H2bc18 Med27 Med12 Med1 H2az2 Med13 H2bc4 Med14 Hist1h4m H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Pparg Med6 Med16 Tbl1x Med17 Ajuba Med30 Med31 Ppargc1a Ppargc1b Hdac3 Tbl1xr1 Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Abl1 ENSRNOG00000066901 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Fads1 Elovl2 Elovl3 Abcd1 Elovl5 Elovl1 Scp2 Acox1 Acsl1 Acaa1b Hsd17b4 Acot8 Fads2 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10225031 Activation of the TFAP2 (AP-2) family of transcription factors Cited2 Wwox Tfap2c Tfap2a Tfap2b Yeats4 Crebbp Tfap2e Ep300 Cited4 Cited1 CA-DEPENDENT EVENTS%REACTOME%R-RNO-111996.1 Ca-dependent events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Prkar2b Pde1b Pde1c Pde1a Mapk1 Pla2g4a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 CALCINEURIN ACTIVATES NFAT%REACTOME%R-RNO-2025928.1 Calcineurin activates NFAT Fkbp1a Calm3 Ppp3ca Ppp3cb Nfatc1 Nfatc3 Nfatc2 Ppp3r1 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%10222539 Activation, translocation and oligomerization of BAX Bid Bax APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10222195 Apoptosis Ywhag Apip Casp7 Apaf1 Diablol1 Ctnnb1 Prkcq Prkcd Septin4 Bak1 Nmt1 Gzmb Bid Xiap Gsn Casp6 Gas2 Sh3glb2 Add1 Ptk2 Mapk3 Tradd Sptan1 Cflar Ripk1 Tnfsf10 Fas Fadd Faslg Bcl2l1 Acin1 Bmf Mapk8 Opa1 Oma1 Gsdme Gsdmd Apc Traf2 Tjp1 Dsg3 Cdh1 Dsp Dsg1 Dsg2 Kpnb1 Hmgb1-ps34 Ppp3r1 Kpna1 Clspn Casp8 Cycsl2 Dcc Appl1 Pkp1 Hmgb1l2 Hmgb1l1 H1-1 Lmna H1-0 H1-5 H1-4 H4f3 Hmgb2 Fnta Dffa Dffb Cycs Ywhab Ocln Birc2 Bax Plec Bcap31 Satb1 Rock1 Tjp2 Bcl2l11 Stk26 Stk24 Dnm1l Lmnb1 Sfn Vim Mapt Ppp3cc Pmaip1 Bad Casp3 Casp9 Ywhae Mapk1 Bmx Dynll1 Dynll2 Ywhaq Ywhah Ly96 Ticam2 Ticam1 Cd14 Tlr4 Ywhaz SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%10223681 Signal amplification Gna13 P2ry1 Gnai2 Gnai1 Gnai3 Gna11 Aamp Gna14 Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Gnat3 Mapk14 Gnb2 Src Gnb1 Tbxa2r Gnb4 Gnb3 Gnb5 Pla2g4a Gng11 P2ry12 Gng10-ps1 IRS-MEDIATED SIGNALLING%REACTOME%R-RNO-112399.1 IRS-mediated signalling Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Sos1 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-9013700.1 NOTCH4 Activation and Transmission of Signal to the Nucleus Notch4 Ywhaz TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%10223283 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Tnfsf13b Tnfsf11 Lta Ltb Traf2 Tnfsf14 Tnfsf12 Birc2 Tnfrsf13c Ltbr Tnfrsf12a Map3k14 Traf3 Tnfrsf11a Cd40lg Cd40 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%10224933 Regulation of PTEN localization Rps27a Uba52 Pten Nedd4 Xiap Ubb Ubc Usp7 Pml SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 96%10223459 Synthesis of 5-eicosatetraenoic acids Pon2 Alox5ap Alox5 Pon3 Ltc4s Pon1 DEGRADATION OF CDH1%REACTOME%R-RNO-9766229.1 Degradation of CDH1 Ctnnb1 Ctsl Psma4 Psma3 Psma6 Src Psma5 Psma2 Psma1 Rps27a Psmd12 Fyn Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Ctsb Cbll1 Ctss Cdh1 Psmc5 Ctnna1 Psmc2 Rack1 Psmc1 Eps15 Psmc4 Dnm2 Psmc3 Jup Mtbp Ctnnd1 Banp Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222595 Activation of BAD and translocation to mitochondria Ywhag Ywhae Bad Ywhaq Ppp3cc Ywhah Sfn Ywhab Ppp3r1 Ywhaz ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors Adrb2 Adrb1 Adra1b Adra2b Adrb3 Adra1a Adra1d Adra2a Adra2c DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223085 Digestion and absorption Cel Pnliprp2 Pnliprp1 Gucy2c Si Lipf Slc2a2 Pir Amy2 Alpi Guca2b Guca2a Lct Clps Chia Pnlip Npc1l1 Slc5a1 Slc2a5 Chit1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%10222765 Glucagon-type ligand receptors Sct Gcgr Sctr Gng3 Adcyap1 Gng5 Vip Gng4 Ghrh Gng7 Gng8 Gngt1 Gcg Gnb2 Ghrhr Gip Gnb1 Gnb4 Gnb3 Gnb5 Glp1r Gng11 Gng10-ps1 Gipr Vipr2 Vipr1 Gnas Glp2r GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME%R-RNO-9840309.1 Glycosphingolipid biosynthesis St8sia5 Fut2 Fut1 St6galnac5 B3galt4 St6galnac6 A4galt Cerk B3galnt1 Ugcg B4galnt1 St3gal5 Ugt8 St3gal2 Gal3st1 St3gal3 B4galt5 B4galt6 B3gnt5 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-RNO-8849471.1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Pxn Bcar1 Rac1 Rhoa Arhgap35 Nras Rasa1 Kras Hras Elmo1 Elmo2 Crk Ptk6 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-RNO-73776.1 RNA Polymerase II Promoter Escape Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-RNO-9841922.1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Ncoa2 Crebbp H2ac18 Hist1h2bq H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 H2bc18 Med27 Med12 Med1 H2az2 Med13 H2bc4 Med14 Hist1h4m H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Pparg Med6 Med16 Tbl1x Med17 Ajuba Med30 Med31 Ppargc1a Ppargc1b Hdac3 Tbl1xr1 Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Abl1 ENSRNOG00000066901 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225327 Drug-mediated inhibition of ERBB2 signaling Erbb2 Cdc37 Hsp90aa1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 96%10222525 E2F mediated regulation of DNA replication Prim2 Prim1 Ppp2cb Rb1 Ppp2r3b Ppp2ca Ppp2r1b Ppp2r1a Pola2 Pola1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-RNO-432047.1 Passive transport by Aquaporins Aqp12a Aqp1 Aqp4 Aqp3 Aqp2 Aqp9 Aqp8 Aqp7 Aqp5 Aqp11 Mip Aqp10 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%10225539 CHD1 and CHD2 subfamily Sf3b1 Hist1h2ai Puf60 Sf3b3 Leo1 Sf3b4 Sf3b5 Snrpepl2 H2ac18 Phf5a Smndc1 Ssrp1 Hist1h2bq Snrpf U2surp Snrpg Skic8 Snrpb Snrpn H2aj Cherp H2ab2 Snrpa1 Rbm17 Ddx46 H3-3b Hist3h2ba H2ac4 Ddx42 Ctr9 Cdc73 ENSRNOG00000068602 Paf1 Snrpd1 Chd1 Chd2 H2bc18 ENSRNOG00000066901 H2az2 Dhx15 H2bc4 Snrpd3 Sf3a1 Hist1h4m Sf3a2 H2bc1 Sf3a3 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-RNO-500753.1 Pyrimidine biosynthesis Umps Cad Dhodh CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222515 Cam-PDE 1 activation Calm3 Pde1b Pde1c Pde1a FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-RNO-6781823.1 Formation of TC-NER Pre-Incision Complex Polr2j Xab2 Gtf2h2 Gtf2h1 Uba52 Gtf2h3 Cdk7 Gtf2h5 Cops4 Ercc2 Ppie Ercc3 Cops2 Tcea1 Cops7a Cops7b Znf830 Mnat1 Aqr Uvssa Prpf19 Ubb Ubc Usp7 Rbx1 Ccnh Cops3 Cops6 Cops8 Isy1 Gps1 Rps27a Polr2c Polr2a Polr2b Cops5 Polr2g Polr2h Polr2e Xpa Polr2f Ercc6 Ddb1 Polr2i Cul4a Cul4b CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%10222617 Clearance of seratonin Maoa Slc6a4 Aldh2 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 96%10223427 Miscellaneous substrates Cyp2s1 Cyp3a9 Cyp3a18 Cyp2w1 Cyp4f39 Cyp4f1 Cyp4a14 Cyp4f3 Cyp3a1 Cyp4a12 Cyp4f40 Cyp2d4 Cyp4b1 Cyp3a62 Cyp3a2 Cyp2u1 Cyp4f4 Cyp4a10 Cyp4a2 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224807 TNFs bind their physiological receptors Tnfsf13b Tnfsf11 Tnfsf8 Tnfsf9 Tnfrsf9 Lta Tnfrsf17 Edaradd Tnfsf15 Tnfrsf1a Tnfsf18 Tnfrsf25 Tnfsf13 Eda2r Tnfrsf18 Eda Tnfrsf4 Tnfrsf8 Tnfrsf1b Edar Tnfrsf11b Tnfsf4 HYDROLYSIS OF LPE%REACTOME DATABASE ID RELEASE 96%10224237 Hydrolysis of LPE Pla2g4c NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%10224683 NIK-->noncanonical NF-kB signaling Psmb6 Psmb1 Psmb3 Psmb2 Relb Uba52 Nfkb2 Fbxw11 Btrc Psma7 Psmc5 Psmc2 Ube2m Psmc1 Uba3 Psmc4 Psmc3 Map3k14 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Chuk Skp1 Psmb5 Psmb4 Psmb7 SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%10222917 Signaling by NODAL Mapk1 Smad2 Smad3 Smad4 Mapk3 Foxo3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME%R-RNO-9954716.1 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Ube2d3 Rplp1 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Trip4 Rps27a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Ube2d1 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Ubb Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Ascc3 Rpl23 Ascc2 Fau Zfp598 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-RNO-162699.1 Synthesis of dolichyl-phosphate mannose Dpm2 Dpm1 Dpm3 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 96%10225465 Maturation of TCA enzymes and regulation of TCA cycle Nfs1 Fxn Isca2 Isca1 Sdhaf1 Sdhaf2 Sdhaf3 Idh2 Sirt3 Sdhd Sdhc Sdhb Sdha Iscu Acat1 Aco2 Lyrm4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%10224465 TRIF-mediated programmed cell death Ripk1 Casp8 Fadd Ly96 Ticam2 Ripk3 Ticam1 Cd14 Tlr4 DNA DAMAGE BYPASS%REACTOME%R-RNO-73893.1 DNA Damage Bypass Wdr48 Ufd1 Uba52 Usp10 Rad18 Pole3 Pole2 Ube2l6 Pole4 Rchy1 Ube2b Rpa1 Rpa2 Polk Trim25 Ubb Rpa3 Ubc Polh Mad2l2 Rev1 Rev3l Poli Pole Rfc5 Pold2 Pold1 Isg15 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Pold4 Vcp Pclaf Pold3 Usp43 Rps27a Usp1 Dtl Nploc4 Sprtn Uba7 Ddb1 Cul4a Cul4b FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling Fgf16 Fgf17 Fgf18 Frs2 Frs3 Nras Grb2 Kras Sos1 Hras Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 96%10222209 Activation of the phototransduction cascade Rho Gngt1 Cnga1 Pde6a Pde6b Gnat1 Pde6g Gnb1 Cngb1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224343 Activated NOTCH1 Transmits Signal to the Nucleus Itch Rps27a Dtx4 Uba52 Ubb Ubc Dtx2 CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction Slc8a1 Slc8a2 Slc8a3 Prkaca Cacna1c Calm3 Nos1 Kcna5 Akap9 Kcne5 Kcnq1 Kcne4 Kcne3 Kcne2 Kcnh2 Cacnb1 Cacnb2 Itpr3 Kcnk4 Itpr2 Kcnk2 Itpr1 Kcnj4 Kcnk1 Atp2a1 Cacng4 Kcnk10 Kcnk16 Cacna2d2 Atp2a3 Kcnj2 Kcnk9 Atp2a2 Kcnk7 Kcnk18 Kcnj14 Kcnk6 Kcnj11 Kcnj12 Abcc9 Cacng6 Cacng7 Atp2b1 Camk2g Kcnd3 Atp2b4 Camk2d Kcnd2 Atp2b3 Kcnd1 Camk2b Kcnip3 Kcnip4 Kcnip1 Kcnip2 Kcnk12 Kcnk15 Sri Npr1 Camk2a Npr2 Kcnk5 Corin Nppc Atp1b1 Nppa Atp1b3 Atp1b2 Ryr2 Ryr1 Fkbp1b Dmpk Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Ahcyl1 Pln Asph Trpc1 Stim1 Tnni3 Cacng8 Mme Kcnk13 Ces1d FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis Prkcd Nckap1l Wipf3 Plpp4 Wipf1 Plpp5 Pld3 Pak1 Ptk2 Mapk3 Lyn Yes1 Src Grb2 Fyn Abi2 Abi1 Arpc3 Arpc2 Cd3g Arpc5 Arpc4 Brk1 Elmo1 Pld1 Wasf3 Wasf2 Hsp90ab1 Wasf1 Arpc1b Actr2 Arpc1a Actr3 Btk Abl1 Nckap1 Cyfip2 Cyfip1 Myo9b Nckipsd Plcg1 Pld4 Myo5a Pld2 Actg1 Elmo2 Pik3ca Rac1 Baiap2 Pik3r1 Pik3cb Hsp90aa1 Vav3 Pik3r2 Vav1 Vav2 ENSRNOG00000069193 Limk1 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Myh9 ENSRNOG00000066406 Myo10 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 Nck1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr Actb ENSRNOG00000065564 Hck ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Myo1c ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 Pla2g6 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Prkce ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 Cdc42 Crk ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 96%10222389 Activation of PKB Them4 Pdpk1 Trib3 Akt2 THE NLRP1 INFLAMMASOME%REACTOME%R-RNO-844455.1 The NLRP1 inflammasome Nlrp1a Bcl2l1 CDC42 GTPASE CYCLE%REACTOME%R-RNO-9013148.1 CDC42 GTPase cycle Ophn1 Def6 Fam13b Myo9b Arhgap31 Arhgap30 Prex2 Arhgap35 Srgap2 Tagap Srgap3 Racgap1 Plekhg3 Ktn1 AABR07032856.1 Syde1 Farp1 Dlc1 Stard13 Arhgap40 Dnmbp Arhgap44 Arhgap42 Spata13 Tiam1 Arhgap32 Mcf2l Cav1 Arhgef15 Arhgdig Arhgef16 Arhgef11 Pik3r1 Arhgef10 Arhgef12 Ngef Arhgef19 Vav3 Pik3r2 Dock6 Vav2 Itsn1 Arhgef26 Dock7 Arhgef25 Dock8 Arhgef6 Arhgef5 Arhgef4 Gna13 Fgd2 Arhgef9 Fgd1 Fgd4 Srgap1 Abr Dock10 Arhgap45 Fgd3 Dock11 Ykt6 Ect2 Prex1 Bcr Trio Arhgap5 Arhgap17 Arhgap4 Arhgap1 Plekhg2 Arap1 Arap3 Arap2 Arhgap9 Arhgap27 Arhgap33 Plekhg1 Ralbp1 Stard8 Arhgdib Gmip Arhgap10 Rasgrf2 Depdc1b Lbr Arhgap22 Cdc42 Arhgap21 Arhgap20 Mcf2 Arhgap26 Arhgdia Arhgap24 Arhgap29 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-RNO-8866652.1 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Uba52 Uchl3 Ube2d1 Ube2w Uba1 Ube2k Ube2t Otulin Cdc34 Ube2b Ube2d2 Ube2a Ubb Ubc Usp5 Usp7 Ube2e1 Ube2g2 Ube2g1 Ube2z Ube2s Rps27a Ube2c Ube2r2 Ube2l3 Uba6 Usp9x Ube2e3 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10223007 Plasma lipoprotein assembly Bmp1 Zdhhc8 Prkaca Prkacb Mttp Apoc1 Apoc2 A2m Apoa1 Apoc4 Apoc3 Apoa2 Sar1b Apoe Apoa4 P4hb Abca1 Apob HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223095 Heme biosynthesis Abcg2 Uros Alas1 Alas2 Hmbs Cpox Fech Alad Alb Ppox Cox10 Cox15 Urod RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225349 RND1 GTPase cycle Stip1 Wdr6 Txnl1 Grb7 Kif14 Epha2 Frs2 Dlg5 Ccdc88a Frs3 Tmem59 Ubxn11 Arhgap35 Cpd Ankrd26 Dst Dsp Arhgap5 Plxna1 Plekhg5 Rras2 Stmn2 Fam83b Cav1 Rnd1 Flot2 Aldh3a2 Pik3r1 Pik3r2 Rbmx Depdc1b Ptpn13 Vangl2 Tfrc Epsti1 Muc13 Fam135a Kidins220 Rasal2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 96%10222563 Response to elevated platelet cytosolic Ca2+ Aldoa Serpina3n Timp3 Fam3c Prkcg Serpinf2 Prkca Tln1 F13a1 Anxa5 Fn1 Calm3 Qsox1 Pdgfa Pdgfb Brpf3 Vegfa Lgals3bp Alb Vegfd Vegfc Lamp2 Vegfb Wdr1 Apoa1 Maged2 Kng1 Endod1 App Serpina4 F8 Actn2 Habp4 Cdc37l1 Serpina1 Tagln2 Cd36 Itih4 Itih3 Pros1 Cd109 Nhlrc2 Fermt3 Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Igf2 Igf1 Hgf Sparc Apoh Vcl Gtpbp2 Orm1 Ecm1 Tuba4a Ola1 Prkcb Ctsw Psap Actn4 Ppbp Flna Tmsb4x Cd63 Tor4a Tgfb1 Tgfb2 Tgfb3 Fgb Fga Fgg Pcdh7 Tmx3 Itga2b Scg3 Selp Plg Cyrib Sccpdh Egf Srgn Serping1 Pecam1 Itgb3 Clu Actg1 Actn1 Aplp2 Timp1 Cyb5r1 Mmrn1 Cd9 Plek Sod1 A2m Tf Phactr2 Stxbp2 Stxbp3 Vti1b Chid1 Abcc4 Cfd Pf4 A1bg Rab27b Serpine1 Islr Pcyox1l Hrg Lhfpl2 Gas6 Sytl4 Ly6g6f Ahsg Spp2 Stx4 NEDDYLATION%REACTOME DATABASE ID RELEASE 96%10224847 Neddylation Rbbp7 Ube2d3 Ube2d2 Gps1 Nploc4 Kbtbd7 Commd9 Fbxw11 Cops4 Cops2 Commd3 Psma4 Psma3 Psma6 Cops3 Psma5 Cops6 Psma2 Cops8 Psma1 Rps27a Psmd12 Dtl Psmd11 Psmd14 Psmd13 Skp2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Nub1 Neurl2 Commd8 Ube2d1 Fem1b Fem1a Tulp4 Btrc Fem1c Psma7 Dcaf8 Dcaf4 Dcaf5 Dcaf6 Psmc5 Dcaf7 Psmc2 Ccdc22 Psmc1 Obsl1 Psmc4 Cops7a Dda1 Psmc3 Cops7b Ccdc8 Commd4 Commd5 Commd6 Commd7 Commd2 Spsb3 Ubb Ankrd9 Socs2 Ubc Commd10 Socs6 Psmb6l1 Ubd Wdtc1 Psmd7 Dcun1d5 Dcun1d4 Psmd6 Dcun1d3 Psmd8 Cish Dcun1d2 Psmd2 Dcun1d1 Cul9 Psmd1 Dcaf17 Dcaf10 Adrm1 Cul1 Dcaf11 Epas1 Hif3a Hif1a Keap1 Ddb2 Ufd1 Uchl3 Lrr1 Fbxl21 Wsb1 Ccnf Nedd8 Mul1 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Fbxw2 Klhl5 Klhl3 Klhl2 Senp8 Spsb2 Spsb1 Spsb4 Eloc Elob Kctd7 Kctd6 Ube2m Ube2f Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Lrrc41 Klhl13 Klhl11 Fbxo21 Fbxo22 Fbxo27 Cand1 Fbxw17 Klhl25 Klhl21 Btbd6 Socs5 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Zbtb16 Cul2 Cul5 Cul7 Fbxo41 Fbxo44 Wdr5 Nfe2l2 Klhl41 Fbxo40 Btbd1 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Fbxo4 Fbxo6 Rbbp5 Fbxo7 Fbxo9 Vhl Fbxl15 Fbxl16 Fbxl19 Asb9 Asb7 Asb6 Asb5 Asb4 Asb1 Ubxn7 Rbx1 Socs3 Vcp Cop1 Cops5 Birc5 Cul3 Ddb1 Dcaf13 Cul4a Cul4b NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222153 Nucleotide biosynthesis Atic Adsl Ppat Adss2 Pfas Paics Gart Adss1 Umps Cad Gmps Dhodh Impdh2 Impdh1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223721 P2Y receptors P2ry10 P2ry4 P2ry13 P2ry12 P2ry1 Lpar6 Lpar4 P2ry14 P2ry2 Gpr17 P2ry6 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450604.1 KSRP (KHSRP) binds and destabilizes mRNA Parn Khsrp Dis3 Akt1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Exosc3 Exosc2 Ywhaz ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%10222537 Activation and oligomerization of BAK protein Bak1 Bid L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10222409 L1CAM interactions Itga2b Ranbp9 Csnk2a2 Csnk2a1 Itgb1 Ank1 Itgb3 Sdcbp Fgfr1 Csnk2b Spta1 Rac1 Pak1 Ncam1 Sptb Sptbn1 Sptbn2 Mapk3 Nfasc Sptan1 Src Sptbn5 Sptbn4 Vav2 Map2k2 Map2k1 Dnm2 Nrp1 Ap2m1 Itga9 Clta Cltc Egfr Dnm1 Lypla2 Gap43 Dpysl2 Kif4b Ap2s1 Kif4a Mapk1 Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Numb Sh3gl2 Ezr Itgav MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis Nfs1 Hscb Fxn Isca2 Isca1 Fdx2 Iscu Fdxr Fdx1 Glrx5 Lyrm4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%10223757 Nectin Necl trans heterodimerization Nectin2 Pvr Nectin4 Cadm3 Cadm1 Nectin1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 96%10224227 Assembly of collagen fibrils and other multimeric structures Loxl2 Bmp1 Loxl1 Loxl4 Tll2 Tll1 Col15a1 Loxl3 Ctsb Ctss Ctsl Lox Col10a1 Mmp7 Col3a1 Mmp3 Col5a2 Col4a1 Col5a3 Col24a1 Col4a2 Mmp9 Col5a1 Pcolce Col11a1 Col11a2 Pxdn Col18a1 Col2a1 Col27a1 Col7a1 Mmp20 Mmp13 Col8a1 Col8a2 HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation Eif5a2 Dohh Dhps Eif5a SIGNALING BY NTRK3 (TRKC)%REACTOME%R-RNO-9034015.1 Signaling by NTRK3 (TRKC) Plcg1 Src Ntrk3 Ntf3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224183 Voltage gated Potassium channels Kcna10 Kcnb1 Kcna2 Kcns3 Kcnc4 Kcna1 Kcnc2 Kcnc3 Kcng2 Kcnc1 Kcng4 Kcng3 Kcng1 Kcnh1 Kcnv2 Kcnv1 Kcna5 Kcnq1 Kcnh2 Kcnb2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnd3 Kcnf1 Kcnd2 Kcnh3 Kcnd1 Kcnq5 Kcnab1 Kcns2 Kcns1 Kcnab3 Kcnab2 Kcna7 Kcna6 Kcna4 Kcna3 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling Ifnl1 Ifnl3 Jak2 Stat3 Stat1 Ifnlr1 Il20rb Jak3 Il20ra Tyk2 Il22ra2 Ptpn11 Il10rb Il22 Il20 Stat5a Il24 Stat5b Il22ra1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%10222529 Cytochrome c-mediated apoptotic response Mapk1 Casp3 Casp7 Apip Cycsl2 Diablol1 Casp9 Apaf1 Cycs Xiap Mapk3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-6782315.1 tRNA modification in the nucleus and cytosol Qng1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%10222581 Elevation of cytosolic Ca2+ levels P2rx1 Trpc3 Itpr3 Itpr2 P2rx7 Itpr1 P2rx6 P2rx5 P2rx4 P2rx3 Trpc7 P2rx2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex Iws1 Cdk7 Ell Ccnk Tcea1 Ccnt2 Ssrp1 Eloa2l Mnat1 Eloa Aff4 Supt6h Cdc73 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Mllt3 Ncbp2 Mllt1 Ncbp1 Gtf2h2 Leo1 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Cdk9 Skic8 Eaf1 Eaf2 Ccnh Ctr9 Paf1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%10223749 Regulation of actin dynamics for phagocytic cup formation Nckap1l Wipf3 Wipf1 Pak1 Ptk2 Mapk3 Grb2 Abi2 Abi1 Arpc3 Arpc2 Cd3g Arpc5 Arpc4 Brk1 Elmo1 Wasf3 Wasf2 Hsp90ab1 Wasf1 Arpc1b Actr2 Arpc1a Actr3 Btk Abl1 Nckap1 Cyfip2 Cyfip1 Myo9b Nckipsd Myo5a Actg1 Elmo2 Rac1 Baiap2 Hsp90aa1 Vav3 Vav1 Vav2 ENSRNOG00000069193 Limk1 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Myh9 ENSRNOG00000066406 Myo10 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 Nck1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Actb ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Myo1c ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 Cdc42 Crk SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 96%10224133 Signaling by ERBB4 Wwox Aph1b Wwp1 Erbb3 Ereg Uba52 Esr1 Nrg2 Nedd4 Nrg3 Btc Egf Ubb Stat5a Ubc Egfr Pik3ca Shc1 Yap1 Hbegf Src Pik3r1 Nras Itch Rps27a Grb2 Kras Sos1 Hras Psenen Psen1 Psen2 Ncstn Aph1a RET SIGNALING%REACTOME%R-RNO-8853659.1 RET signaling Rap1gap Irs2 Grb7 Dok2 Shank3 Prkaca Frs2 Prkacb Dok1 Plcg1 Pdlim7 Dok4 Dok5 Dok6 Prkca Grb10 Ret Pik3ca Shc3 Shc1 Pspn Gab2 Gdnf Src Artn Pik3r1 Pik3cb Gfra1 Gfra2 Grb2 Pik3r2 Gfra4 Pik3r3 Pik3cd Sos1 Ptpn11 Nrtn Mapk7 Gab1 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-RNO-429958.1 mRNA decay by 3' to 5' exoribonuclease Skic8 Dcps Dis3 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Nt5c3b Exosc3 Hbs1l Exosc2 Skic3 Skic2 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-RNO-427975.1 Proton oligopeptide cotransporters Slc15a1 Slc15a3 Slc15a4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%10222531 Apoptotic factor-mediated response Gsdme Casp7 Apip Gsdmd Cycsl2 Diablol1 Apaf1 Mapk3 Bax Septin4 Mapk1 Bak1 Casp3 Casp9 Cycs Xiap POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10225119 Post-translational protein phosphorylation Ttgn1 Men1 Igfbp3 Fn1 Qsox1 Alb Serpina10 Notum Apoa1 Apoa2 Kng1 Mia3 Apoe P4hb Apob App Fgf23 Sdc2 Serpind1 Serpina1 Gpc3 Serpinc1 Ckap4 Cdh2 Il6 Prkcsh Adam10 C3 Hsp90b1 Fga Fgg Scg3 Ltbp1 Proc Spp1 Bmp4 Ktn1 Fbn1 Aplp2 C4b Timp1 Megf11 Chgb Pdia6 C4 Ccn1 Amelx Lgals1 Csf1 Scg2 Apoa5 Meltf Mxra8 Fam20a LOC120093819 Fam20c Tf Fuca2 Stc2 Wfs1 Apol7al1 Hrc Pcsk9 Ambn Mepe Cp Dnajc3 Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Penk Igfbp7 Mfge8 Matn3 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tmem132a Afp Pnpla2 Mbtps1 Igfbp5 Igfbp4 Tnc Golm1 Igfbp1 Amtn Dmp1 Mgat4a Nucb1 Sparcl1 Msln Vcan Cst3 Itih2 Apol9a Gas6 Ahsg Spp2 HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors Hrh1 Hrh4 Hrh2 Hrh3 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%10222149 Formation of a pool of free 40S subunits LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%10225425 MITF-M-dependent gene expression Lef1 Tcf7l1 Rab27a Tcf7l2 Ctnnb1 Sin3a Hint1 Mitf Myo5a Myrip Sytl2 Hdac1 Tcf7 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 96%10224203 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225441 TGFBR3 regulates FGF2 signaling Tgfbr3 Gipc1 Fgf2 ONCOGENE INDUCED SENESCENCE%REACTOME%R-RNO-2559585.1 Oncogene Induced Senescence Uba52 Id1 Cdk6 Ets1 Mapk3 Ets2 Mapk1 Rps27a Cdkn2b Cdkn2d Mdm4 Erf Cdk4 Ubb Ubc Tp53 MRNA 3'-END PROCESSING%REACTOME%R-RNO-72187.1 mRNA 3'-end processing Ppp1ca Srrm2 Snrpepl2 Hnrnph2 Hnrnph1 Papolg Ppp1r8 Rbm25l1 Prr3 Ybx1 Dnajc8 Rbm25 Rbm5 Rbm17 Ddx46 Ddx42 Pcf11 Fip1l1 Cstf1 Rbmx Papola Nudt21 Polr2c Tra2b Cstf2 Polr2a Cstf3 Polr2b Polr2g Cstf2t Polr2h Sympk Polr2e Polr2f Pabpn1 Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2f2 Gtf2f1 Ppp1cb Phf5a Hnrnpr-ps2 U2surp Snrpa1 Ptbp1 Tut1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 Hnrnpa2b1 Srrt Snrnp70 Htatsf1 Snrpa Snrpc Snrpn Cherp Fus Rps27a Srsf1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Puf60 U2af1 Uba52 Hnrnpa1 Rbbp6 U2af1l4 Tcerg1 Smndc1 Dhx9 Prpf40a Cdc40 Pcbp2 Snrpf Ubb Pcbp1 Ubc Snrpg Snrpb Hnrnpr Hnrnpu Rbm10 Sugp1 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 Sin3a Hdac2 Lbr Hdac1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%10223181 Axonal growth stimulation Ngfr Ngf Arhgdia Rhoa ER-PHAGOSOME PATHWAY%REACTOME%R-RNO-1236974.1 ER-Phagosome pathway Psmb6 RT1-M1-5 Psmb3 Vamp8 Rt1-ec3 Psme2 Psme1 Psma7 Psmb9 Psmb10 Psmb8 RT1-M6-2 Vamp3 AABR07044308.1 Pdia3 B2m Psmb6l1 RT1-M10-ps1 RT1-M10-ps5 Snap23 Psma4 RT1-N3 Psma3 Psma6 RT1-M5 Psma5 Psma2 Psma1 RT1-M2 RT1-M1-2 Psmb4 Psmb7 CALMODULIN INDUCED EVENTS%REACTOME%R-RNO-111933.1 Calmodulin induced events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Prkar2b Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 96%10223191 NRAGE signals death through JNK Arhgef7 Tiam1 Mcf2l Tiam2 Rac1 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Ngef Arhgef19 Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Mapk8 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Plekhg5 Plekhg2 Net1 Arhgef10l Rasgrf2 Mcf2 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism Txnrd1 Scly Sephs2 Mat1a COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin Smc3 Stag2 Stag1 Wapl Pds5b Pds5a Nipbl Mau2 Smc1a LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-RNO-140534.1 Ligand-dependent caspase activation Casp8 Traf2 Tradd Cflar Ripk1 Tnfsf10 Fas Fadd Faslg Ly96 Ticam2 Ticam1 Cd14 Tlr4 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222011 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Pfkfb1 Pfkfb4 Pfkfb3 Pfkfb2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-RNO-1606322.1 ZBP1(DAI) mediated induction of type I IFNs Ikbkg Nfkbib Nfkb2 Nfkb1 Irf3 Nfkbia Rela Dhx9 Nkiras1 Chuk Myd88 Ikbkb Nkiras2 RHOF GTPASE CYCLE%REACTOME%R-RNO-9035034.1 RHOF GTPase cycle Rhof Akap12 Arhgap12 Myo9b Srgap2 Vamp3 Arhgap5 Syde1 Farp1 Sowahc Arhgap1 Actg1 AABR07021573.2 Actn1 Rab7a Mcam Basp1 Snap23 Arhgap32 Cav1 Mtmr1 Fam169a Slc4a7 Pik3r1 Baiap2l2 Baiap2l1 Diaph3 Add3 Diaph1 Pik3r2 Tor1aip1 Steap3 Lmnb1 Depdc1b Senp1 Esyt1 Arhgap21 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%10223933 Activation of kainate receptors upon glutamate binding Grik5 Grik2 Grik1 Grik4 Calm3 Grik3 Ncald Dlg1 Dlg3 Dlg4 MRNA POLYADENYLATION%REACTOME%R-RNO-9770562.1 mRNA Polyadenylation Ppp1ca Srrm2 Snrpepl2 Hnrnph2 Hnrnph1 Papolg Ppp1r8 Rbm25l1 Prr3 Ybx1 Dnajc8 Rbm25 Rbm5 Rbm17 Ddx46 Ddx42 Pcf11 Fip1l1 Cstf1 Rbmx Papola Nudt21 Polr2c Tra2b Cstf2 Polr2a Cstf3 Polr2b Polr2g Cstf2t Polr2h Sympk Polr2e Polr2f Pabpn1 Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2f2 Gtf2f1 Ppp1cb Phf5a Hnrnpr-ps2 U2surp Snrpa1 Ptbp1 Tut1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 Hnrnpa2b1 Srrt Snrnp70 Htatsf1 Snrpa Snrpc Snrpn Cherp Fus Rps27a Srsf1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Puf60 U2af1 Uba52 Hnrnpa1 Rbbp6 U2af1l4 Tcerg1 Smndc1 Dhx9 Prpf40a Cdc40 Pcbp2 Snrpf Ubb Pcbp1 Ubc Snrpg Snrpb Hnrnpr Hnrnpu Rbm10 Sugp1 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 SELECTIVE AUTOPHAGY%REACTOME%R-RNO-9663891.1 Selective autophagy Map1lc3b Csnk2a2 Csnk2a1 Ube2d3 Ube2d2 Park7 Csnk2b Tomm20 Sqstm1 Src Prkn Optn Rps27a Usp30 Ube2l3 Ulk1 Pex5 Dync1h1 Ube2n Uba52 Dync1i2 Dync1i1 Ubb Ubc Mfn1 Mfn2 Tomm22 Atg5 Tbk1 Atg12 Vdac2 Atg9a Pcnt Vdac3 Atm Pgam5 Vdac1 Dync1li2 Tomm40 Dync1li1 Tomm70 Arl13b Dynll1 Mterf3 Dynll2 Map1lc3a Pink1 Fundc1 Tomm7 Nbr1 Cftr SYNTHESIS OF DNA%REACTOME%R-RNO-69239.1 Synthesis of DNA Gins2 Gins1 Gins4 Gins3 Dna2 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Psmb7 Cdc6 Psmb6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Pole Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%10222677 Immune System Fuca1 Mmtag2 Nbeal2 Prdx4 Plac8 Pgrmc1 Commd9 Retn Lgals3 Ptprn2 Bin2 Cd36 Pa2g4 S100a11 S100a9 Dynlt1 Gmfg Syngr1 Clec4a3 Clec4a2 Glipr1 Man2b1 Tmc6 Clec4b2 Grn Ceacam6 Enpp4 Cgm4 Ypel5 Nfam1 Clec6a-ps1 Aga Commd3 Pigr Pygb Crispld2 Ormdl3 Dnajc13 Lilrc2 Rab44 Adgrg3 Chrnb4 Ear1l1 Epx Kcmf1 Tom1 Serpinb1a Prkcb Rab37 Serpinb12 Serpinb10 Psgb1 Pkp1 Dsc1 Bri3 Gpr84 Ptprb Ghdc Lamp1 Arl8a Rab3d Nit2 Chi3l1 Mospd2 Acp3 Slc2a5 Alad Crisp2 Olfm4 Atad3a Fgl2 Dnase1l1 Hgsnat Mnda Frmpd3 Rnase17 Agpat2 Fcgr3a Mcemp1 Scamp1 Tmem179b Cant1 Unc13d Cpne1 Cpne3 Tmem30a Rnase2 Rnase3 Vat1 Tspan14 Prg3 Anpep Atp6v0b Prg2 Trib3 Bst2 Atp6v0a4 Rap2b Grb10 Rap2c Manba Atp6v1g3 Atp6v0e2 Cap1 Mlec Atp6v1c2 Cd53 Atp6v0a1 Atp6v1c1 Stk11ip Svip Atp6v0c ENSRNOG00000064486 Them4 Qpct ENSRNOG00000064129 Tlr9 Irag2 Cstb Gca Erp44 Atp6v1e2 Creg1 Atp6v1e1 Cd68 Tcirg1 Atp6v1a Dok3 Hebp2 Atp6v1b2 Cd93 Atp6v0d2 ENSRNOG00000067708 Atp6v0d1 Atp6v1b1 Cotl1 Atp6v0e1 Dpp7 Tarm1 Atp6v1g2 Degs1 Atp6v1g1 Atp6v1f Ggh Atp6v1d Cnn2 Psg29 Dnajc5 Ddx3x Cracr2a Clec4a Clec4d Cpped1 Mvp Ms4a3 Pdap1 Kcnab2 Oscar Ap1b1 Tmem63a Cmtm6 Ap1m2 Tnfaip6 Vamp7 Vps35l Ostf1 Ap1m1 Ptx3 Vamp8 Ap1s3 Ap1s2 Txndc5 Ap1g1 Hspa8 Cd180 Ly86 Ptpn4 Tasl Eea1 Lrr1 Nedd4 Tlr10 Irf5 Rnf220 Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb RT1-M6-2 Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 B2m Dcaf1 Rnf126 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Rnf111 RT1-M10-ps1 RT1-M10-ps5 Snap23 Siah1 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 RT1-N3 Rnf130 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Klhl2 Ube4a Spsb2 RT1-M1-2 Trim9 Spsb1 Trip12 Wwp1 RT1-M1-5 Spsb4 Rt1-ec3 Lrsam1 Eloc Huwe1 Elob Ube2j1 Kctd7 Ube2u Kctd6 Ncf1 Ncf2 Ube2w Ncf4 Ube2m Ube2k Rnf182 Ube2o Ltn1 Pdia3 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Trim71 Klhl25 Ube2e3 Ube2e2 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Hspa5 Uba1 Cyba Cybb Uba3 Cul2 Myo5a Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Rchy1 Asb1 Lnx1 Lpcat1 Clec7a Card9 Gpi Pgam1 Aldoc Aldoa Pfkl Pkml1 Hk3 Hspa1b Hspa1a Kif3a Clec4e Crkl Rapgef1 S100a1 Gsdme Tlr1 Gsdmd Tlr7 Tlr6 Lbp S100a8 Tlr2 Arhgap45 Stom Arhgap9 Pld1 Stk10 Faf2 Diaph1 C1qbp Stbd1 Dock2 Myo9b Racgap1 Rock1 Dhx36 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Eif2ak2 Psmb1 Fancl Psmb3 Fancm Psmb2 Myh9 Pim1 Uba52 Fanca Myo10 Fancb Anapc10 Fancc Mapt Ube2d1 Fance Fancf Btrc Fancg Psma7 Nck1 Gbp5 Pde12 Ilf2 Psmc5 Actb Psmc2 Dus2 Psmc1 Ilf3 Psmc4 Flnb Psmc3 Snca Anapc5 Dhx9 Ppm1b Anapc4 Mx2 Arih1 Anapc1 Anapc2 Pggt1b Trim25 Fzr1 Ptpn2 Ubb Hspa1l Anapc7 Gbp2 Ubc Gbp1 Nek2l1 Gbp3 Ube2e1 Faap100 Psmb6l1 Npm1 Psmd7 Casp1 Oasl Psmd6 Hspa2 Psmd8 Faap24 Isg15 Psmd2 Faap20 Psmd1 Adrm1 Cul1 Cdc16 Cdk1 Mapk1 Ppp2cb Ppp2ca Prkaca Prkacb Prkcd Gusb Calm3 Ppp2r5d Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Ppp2r1b Il1b Ppp2r1a Il1r2 Il1r1 Nfasc Ctsh Hbb Ckap4 Tp53 H2ab2 H2ac4 Abl1 ENSRNOG00000066901 Ccnd1 Crebbp Kmt2a Kmt2c H2ac18 Csnk2a2 Ctsk Ctsl Csnk2a1 Hist1h2bq Wdr5 Ash2l Csnk2b H2aj Smarca4 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Itch Ptpn11 H2bc18 H2az2 Rbbp5 H2bc4 Hist1h4m H2bc1 Hist1h2ai Neu1 Glb1 Ctsa Rnf185 Prkaa1 Derl3 Prkaa2 Derl2 Stt3b Rbx1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Rbbp4 Rbbp7 Ppie Mib2 Pdcd1lg2 Prkab2 Prkab1 Ybx1 Creb1 Sptbn2 Ptk2 Mapk3 Sptan1 Ddx41 Rps6ka5 Nras Tnfsf13 Grb2 Fyn Kras Sos1 Hras Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Slc15a4 Mapk7 Nkiras2 Iqgap2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Tnf Fos Vrk3 Tnfrsf1a Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Ptges2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Cep290 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Tubb5 Itgav Tubb4b Furin Cdk13 Itgb1 Kif26a Rbsn Kif11 Kif15 Kif5a Kif5b Akt3 Akt2 Akt1 Optn Rab31 Kif22 Kif23 Kif20a Klc1 Kifap3 Klc4 Klc3 Klc2 Kif3b Kif3c Sh2b1 Rab3a Stxbp2 Cxadr Plcg2 Gdi2 Rab7a Prkce Cfd A1bg Rab27a Prkg1 Hrg Olr1 Tbc1d10c Pik3r6 Trappc1 Rab6a Ceacam1 Rab5c Ahsg Rab5b Stx4 Serpina3n F12 Serpinb6a Rab9b Jaml Rab10 Rab14 Rab18 Anxa2 Qsox1 Itga4 Lamp2 Pnp Ampd3 Cd177 Itpr3 Itpr2 Itpr1 Aprt Lyn Yes1 Src Rhoa Lrrc7 Itgal Camk2g Camk2d Camk2b Itgb2 Lcp2 Camk2a Zap70 RT1-Db2 Cd3g P2rx1 Cd247 RT1-Db1 Cd3e Cd3d Aamp Trav19 Trem1 AC109737.1 Cd4 RT1-Ha Mif Lck Ptpn22 RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da Ifng Ifngr2 Ifngr1 Raf1 Jak2 Orm1 Rhog Rac2 Ano6 Atp6ap2 Cd47 Ctsd Mme Ctsg Cd63 Ctsz Cd74 Prtn3 Cpb2 Ppia Aim2 Fcer1g Psme2 Psme1 Psmb9 Psmb10 Psmb8 Sell Sirpa Plau Pecam1 Nos1 Inpp5d Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Csf1 Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Inppl1 Pik3cd Fuca2 Pik3r5 Pik3cg Irs2 Bpifb2 Alox5 Lta4h Cst3 Sec13 Hpse Csf3 Nckap1l Wipf3 Wipf1 Sar1b P4hb Apob Abi2 Abi1 Arpc3 Arpc2 Arpc5 Arpc4 Brk1 Dsp Dsg1 C3ar1 Wasf3 Wasf2 Wasf1 Arpc1b Actr2 Arpc1a Ppbp Fpr1 Actr3 Btk Fpr2 C3 Nckap1 C5 Cyfip2 Cyfip1 Rhof Nckipsd Pld2 Elmo2 Baiap2 Ccr6 Limk1 F2 Pdxk Bst1 Vnn1 Ptafr Naprt Slc2a3 Cyb5r3 Cd55 Cxcr1 Cxcr2 Folr2 Ghr Gh1 Prl Prlr C5ar2 C5ar1 Atp7a Defb41 Defb42 Np4 Defb43 Defb44 Kng1 Defa24 Svs3b Ear1 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Pglyrp2 Reg3a Reg3b Pglyrp3 Pglyrp4 Defa31 Stath Reg3g Bpi Defa Camp Chga Ltf Lyz1 Bpifa1 Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Defb24 Defb1 Slc11a1 Defb25 Eppin Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Malt1 Bcl10 Nfkbie Rel Psap Pias1 Adgre5 Cxcl1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Fcgr2 Cd28 Syk Icos Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr ENSRNOG00000065564 Frk Rictor Hck Cd86 ENSRNOG00000066971 Cd80 ENSRNOG00000063341 Prr5 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Il1rl1 Trat1 ENSRNOG00000063148 Igkvl13 Casp9 AABR07065812.2 Mapkap1 ENSRNOG00000063707 Madcam1 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 Itgb7 ENSRNOG00000064481 Icam1 ENSRNOG00000065690 ENSRNOG00000064085 Icam5 ENSRNOG00000066904 Icam4 ENSRNOG00000063713 Icam2 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 Vcam1 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Hvcn1 Prkcq Rasgrp1 Cfp Rap1a Rap1b Tyk2 Bcl2l1 Kbtbd7 Il6st Ppp2r5b Ppp2r5a Golga7 Brwd1 Tslp Il7 Il7r Ppp2r5e Btla Irs1 Fcer1a Txk Ppp3ca Ppp3cb Itk Nfatc1 Nfatc3 Nfatc2 Ppp3r1 Grap2 Lamtor3 Ms4a2 Lamtor2 Tec Vcl Il6 Ist1 Il6r Fnta Fntb Lat Flt3 Ywhab Fgb Fga Fgg Csk Pld4 Mapk12 Il1rapl1 Nme2 Slc44a2 Fkbp1a Mtor Cab39 Lamtor1 Mlst8 Mgst1 Gstp1 Pak1 Pak2 Apeh Mre11 Ube2v2 Trpc1 Stim1 Xrcc6 Xrcc5 Herc2 Sumo1 Unc93b1 Lgmn Tlr8 Cnpy3 Padi2 Sfn Kif18a Dync1h1 Dync1i2 Dync1i1 Cenpe Arg1 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Aoc1 Dynll1 Dynll2 Ywhaz Pdpk1 ENSRNOG00000070986 Lat2 Ctnnb1 Cd101 Pag1 Ptprc Fyb1 Smurf2 Ctsb Cbll1 Ctss Dnm2 Jup Impdh2 Pycard Panx1 Impdh1 Txnip Sugt1 Nlrp3 Txn Mefv Pstpip1 Nlrp1a Hsp90ab1 P2rx7 Tbk1 Irf3 Mavs Rig1 Tax1bp1 Ikbke Cyld Gns Galns Hexb H2az1 Krt1 Prcp Plcg1 Pla2g2a Sdcbp Rac1 Pak3 Hsp90aa1 Sphk1 Srp14 Foxo3 Mmp9 Fkbp5 Nos3 Fabp5 Il12rb1 Il12rb2 Ebi3 Il12b Il27 Il23a Actr1a Il12a Crlf1 Il23r Dctn1 Dctn2 Icoslg Dctn4 Sec23a Ctsc Arf1 Copb1 Sec31a Serpina1 Actr10 Sec24d Sec24c Sec24b Sec24a Cd59 Idh1 Adar Socs1 Il13ra2 Il4r Stat6 Il13 Hsp90b1 Socs5 Il4 Stat3 Stat1 Actg1 Sqstm1 Vav3 Vav1 Vav2 Psen1 Sos2 Ncstn Myo1c Casp3 Casp2 Myd88 Ap2m1 Clta Cltc Dnm1 Socs3 Cbl Cdc42 Slco4c1 Ube2d3 Ube2d2 Acaa1b Stx1a Slc27a2 Sting1 Mapk13 Vamp2 Eda Tnfrsf4 Tnfrsf8 Tnfrsf1b Edar Tnfrsf11b Tnfrsf11a Cd40lg Tnfsf4 Cd40 Tnfsf13b Tnfsf11 Cat Tnfsf8 Tnfsf9 Relb Tnfrsf9 Lta Ltb Tnfrsf17 Edaradd Tnfsf15 Tnfsf14 Vapa Tnfsf12 Tnfrsf13c Tnfsf18 Ltbr Tnfrsf25 Nos2 Eda2r Tnfrsf18 Tnfrsf12a Map3k14 Ube2j2 Kpnb1 Kpna1 Armc8 Kif4b Ap2s1 Kif4a Dnm3 Ap2a2 Ap2a1 Ap2b1 Ifi44 Sh3gl2 Ifi44l Osbpl1a Chit1 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Snap29 Masp1 Masp2 C4b C1qb Crp C1qa Cfh Cfi C2 Elane C4 Hp Colec10 C6 C9 Cd46 Cfhr1 C1s C1r Cpn1 Cpn2 Cd19 C1qc Sh3kbp1 Fth1-ps5 Pik3c3 Pafah1b2 Fth1 Pik3r4 Prkra Tarbp2 Ftl1 Itgax Pla2g6 Crk Igf2r Vamp3 Nlrp4 Dtx4 Gsn Sh3glb2 Plpp4 Plpp5 Pld3 Eef2 Il34 Ptprz1 Il16 Txlna Csf1r Stx3 Calr Arsa Lpo Mpo Asah1 Gm2a Il18 Gla Arsb Nectin2 Pvr Rab4b Cand1 Rnf19b Hace1 Birc2 Canx Npc2 Plaur Trpm2 Atp11b Atp11a Atp8b4 Smurf1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 Hmox2 Cd207 Mrc2 Mrc1 Ripk3 Prkn Stub1 Ripk1 Capza1 Capza2 Fadd Il1rl2 Il1f10 Ube2l3 Dapp1 Cd22 Blnk Ttr Cd79a Cd79b Il36a Il36rn Il36g Il18rap Il18r1 Il18bp Dgat1 Sdc1 Elmo1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Ppl Xdh Mmp25 Adam10 Adam8 Mmp8 Try10 Prss2l1 Tyrobp Klkb1 Trem2 Try5 Cd44 LOC102554637 Capn1 Timp2 Prss2 Acly Prss3 Prss1 A2m Eef1a1 Cntf Cntfr Ifnlr1 Clcf1 Ctf1 Il20rb Il20ra Il31ra Lif Il10 Il11 Il22ra2 Osmr Il10rb Il10ra Il22 Il11ra1 Il20 Il24 Osm Il22ra1 Lifr Ifnl1 Ifnl3 Becn1 Tomm70 Rnf123 Dera Pgm2 Siah2 Keap1 Clec5a Siglec15 Siglec10 Klrd1 Klrc2 Klrk1 Klrc1 Apaf1 Il33 Cda Ndufc2 Pten Aldh3b1 Snap25 Tirap Actr1b Siglec1 Siglec5 Siglec8 LOC100910497 Slamf6 Slamf7 Hcst Kir3dl1 Pilrb2l4 Ctla4 Cct2 Ifitm1 Ifitm2 Ifitm6 Pilrb1l3 Rap1gap Lag3 Pilrb-ps7 Cd160 ENSRNOG00000070312 Pianp Cd226 Ifitm3-ps2 LOC134481331 Ifi30 Lair1 Rilp Treml2 Treml4 Cd200 Ctse Cct8 Ctsf Cd1d Ctso ifitm3 Cd34 Sipa1 Cd200r1l LOC120093164 Il15 Rap1gap2 Il15ra Cd96 Il9 Il21 RT1-DOa RT1-DOb Ptk2b Stat5a Crtam Stat5b Cd8b Cd8a Il9r Cd300le Cd300ld RT1-DMb Cd300lg Cd300lf Klrb1a Clec4g Clec2e Ifnar1 LOC120103158 Gaa LOC120103159 Ifnar2 Agl Ifnb1 Pygl Rnasel Ifna4 Ifna1 Ifna1l1 Ifna4l1 Irf9 Gyg1 Pgm1 Prdx6 ATTENUATION PHASE%REACTOME%R-RNO-3371568.1 Attenuation phase Hsbp1 Fkbp4 Hspa2 Hsp90ab1 Ptges3 Crebbp Hspa8 Ep300 Hsp90aa1 Hsf1 Hspa1b Hspa1a Dnajb1 Hspa1l PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223539 Proton-coupled monocarboxylate transport Slc16a8 Slc16a1 Bsg Emb Slc16a7 Slc16a3 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 96%10224917 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Rabggta Rabggtb Chm AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 96%10222321 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1963640.1 GRB2 events in ERBB2 signaling Grb2 Erbb2 Kras Sos1 Ereg Hras Nrg2 Nrg3 Hbegf Btc Nras DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions Dscaml1 Dscam TRANSLESION SYNTHESIS BY REV1%REACTOME%R-RNO-110312.1 Translesion synthesis by REV1 Rev1 Rev3l Rfc5 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Rps27a Rpa1 Rpa2 Ubb Rpa3 Ubc Mad2l2 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-RNO-110331.1 Cleavage of the damaged purine Acd Terf1 Hist1h2ai Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Terf2 H2bc1 Neil3 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-RNO-6806667.1 Metabolism of fat-soluble vitamins Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ubiad1 Ttr Gpc1 Vkorc1 Ttpa Rdh11 Gpc3 Vkorc1l1 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Gpc6 Clps Pnlip Akr1b10 Rbp4 Apom Rbp2 Rbp1 Sdc1 Lrat Agrn ASPIRIN ADME%REACTOME%R-RNO-9749641.1 Aspirin ADME Slco2b1 Cyp3a9 Glyatl3 Acsm2 Acsm4 Acsm5 Abcc2 Ugt1a2 Glyat Ugt1a1 Ugt1a3 Abcc3 Ugt1a5 Cyp3a18 Cyp2c66 Cyp2e1 Ugt2b1 Cyp2c11 Ugt1a6 Slc22a7 Ugt1a7 Ugt1a8 Ugt2b7 Cyp3a1 AC114845.1 Cyp2d4 Ugt2b34l1 Cyp3a62 Ugt2b Ugt2a1 Cyp3a2 Ugt2a3 Ces2h Alb Ugt2b17 Ugt2b37 Ugt2b15 Ugt3a1 Bche Slc16a1 Bsg Ces1d GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins Fgb Apbb1ip Fga Fgg Itga2b Ptk2 Src Tln1 Grb2 Rap1a Rap1b Sos1 Fn1 Itgb3 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%10224943 PI5P Regulates TP53 Acetylation Pip4k2b Pip4k2c Pip4p1 Pip4k2a Map2k6 Ep300 Ing2 Tp53 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 Ikbkg Nfkbib Dhx9 Nkiras1 Nfkb2 Nfkb1 Chuk Myd88 Ikbkb Nfkbia Nkiras2 Rela BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-RNO-9027307.1 Biosynthesis of maresin-like SPMs Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a9 Cyp3a62 Cyp3a2 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta Ikbkg Uba52 Nfkb2 Nfkb1 Crebbp Rela S100b Ubb Hmgb1-ps34 Ubc Nfkbib Hsp90ab1 Tbk1 Irf3 Mavs Rig1 Tax1bp1 Ager Ikbke Nfkbia Ep300 Hmgb1l2 Cyld Hmgb1l1 Hsp90aa1 Nlrx1 Tomm70 Rps27a Nkiras1 App Chuk Ikbkb Irf7 Nkiras2 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%10222019 Phase II - Conjugation of compounds Tpst1 Mtr Gsta5 Tpst2 Gsta6 Sult2b1 Gsta3 Gsta1 Sult1a1 Sult1c2 Gsta2 Sult1b1 Chac1 Bpnt2 Glyatl3 Chac2 Sult6b1 Gstm7 Acsm2 Sult4a1 Gstm5 Acsm4 Gstk1 Sult2a2 Acsm5 Bpnt1 Ugt1a2 Ggct Glyat Ugt1a1 Sult2a1 Ugt1a3 Gstm1 Sult2a6 Ugt1a5 Gclc Abhd14b Gstm2 Mgst3 Podxl2 Ugt2b1 Gsto2 Esd Cndp2 Mgst2 Ugt2b7 Mgst1 AC114845.1 Ugt2b34l1 Gclm Ggt1 Ugt2b Ggt5 Ggt7 Ggt6 Hpgds Gstm4 Gss Gstp1 Ugt2b17 Gstt2 Ugt2b37 Akr1a1 Ugt2b15 Gstt1 Mat1a Oplah Abhd10 Ugt1a6 Ugt1a7 Slc35d1 Ugt1a8 Cyp1a2 Nat1 Nat2 Nat3 Ugt2a1 Ugt2a3 Ugt3a1 As3mt Ahcy Comt Mtrr Uxs1 Gsto1 Ugp2 Tpmt Ugdh Mat2a Gstz1 Mat2b Sult1e1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-RNO-9032500.1 Activated NTRK2 signals through FYN Fyn Dock3 Bdnf Rac1 Ntrk2 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 96%10225319 Cellular response to starvation Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6v1e2 Sesn2 Atp6v1e1 Tcirg1 Sesn1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Nprl3 Nprl2 Wdr59 Mios Depdc5 Wdr24 Lamtor3 Fnip1 Lamtor2 Fnip2 Samtor Rptor RragB Itfg2 Castor2 Castor1 Mtor Sec13 Rheb Szt2 Slc38a9 Lamtor5 Lamtor4 Kics2 Rraga Flcn Lamtor1 Rragc Sh3bp4 Rragd Mlst8 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-RNO-1614558.1 Degradation of cysteine and homocysteine Slc25a10 Cth Mpst Usf1 Sqor Ethe1 Fmo1 Suox Ado Txn2 Tst Gadl1 Cdo1 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-RNO-6814122.1 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Csnk2b Rgs7 Pdcl Tcp1 Cct6b Cct7 Cct6a Gnb2 Gnb1 Gnb4 Cct8 Gnb3 Cct5 Gnb5 Cct4 Csnk2a2 Csnk2a1 Cct3 Cct2 Rgs9 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 96%10225521 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) Arhgef4 Tiam1 Uba52 Rac1 Farp2 Ctnnb1 Ctsb Src Cbll1 Ctss Cdh1 Ctnna1 Rps27a Ctsl Vav2 Jup Ctnnd1 Cdc42 Ubb Ubc REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction Izumo1 Cd9 Hyal5 Rad51 Catsperg Catsperd Catsper4 Catsper2 Catsperb Hvcn1 Catsper3 Fignl1 Catsper1 Kcnu1 Acr Dmc1 Firrm Izumo4 Izumo3 Izumo2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222809 Lectin pathway of complement activation Fcn2 Fcn1 Colec10 Mbl2 Masp1 Masp2 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 96%10224345 Signaling by NOTCH1 Itch Rps27a Dtx4 Uba52 Ubb Ubc Dtx2 NTRK2 ACTIVATES RAC1%REACTOME%R-RNO-9032759.1 NTRK2 activates RAC1 Fyn Dock3 Bdnf Rac1 Ntrk2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%10222651 Polo-like kinase mediated events Foxm1 Pkmyt1 Plk1 Wee1 Cdc25c FRUCTOSE BIOSYNTHESIS%REACTOME%R-RNO-5652227.1 Fructose biosynthesis Sord Akr1b1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME DATABASE ID RELEASE 96%10222109 Detoxification of Reactive Oxygen Species Cat Ncf1 Ncf2 Prdx3 Ncf4 Cyba Prdx6 Cybb Nox4 Prdx2 Prdx5 Gpx3 Gpx6 Gstp1 Gpx5 Gpx8 Gpx7 Txn Prdx1 Sod1 Txnrd1 Cycsl2 Nudt2 Ero1a Gsr Txnrd2 P4hb Sod3 Ccs Txn2 Cycs Gpx2 Sod2 Gpx1 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation Rab43 Rab21 Chml Rab9a Rab9b Rab1A Rab10 Rab13 Rab12 Rab2b Rab14 Rab34 Rab18 Rab20 Rab8b Ptp4a2 Rab8a Rab23 Rab26 Rab25 Rab29 Rab40b Rab15 Rab17 Rab19 Rab3c Rab3b Rab36 Rab11b Rab11a Rab31 Rab35 Rab38 Rabggta Rabggtb Rab1b Rab5a Rab4a Rab33b Rab33a Rab3a Chm Rab7a Rab7b Rab44 Rab27a Rab39a Rab27b Rab2a Rab37 Rab4b Rab3d Rab6b Rab6a Rab5c Rab5b FRS2-MEDIATED ACTIVATION%REACTOME%R-RNO-170968.1 Frs2-mediated activation Map2k1 Mapk1 Rap1a Braf Ntrk1 Frs2 Ngf Mapk3 Crkl Ywhab Rapgef1 Map2k2 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 96%10222343 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Acadvl Hadha Hadhb METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 96%10222721 Metabolism of vitamin K Ubiad1 Vkorc1 Vkorc1l1 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9948299.1 Ribosome-associated quality control LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Ube2d3 Rplp1 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Eloc Elob Ltn1 Trip4 Cul2 Pelo Tcf25 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Rps14 Psmd14 Rps15 Psmd13 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Psmb5 Rpl35 Rps10 Psmb4 Rps11 Psmb7 Rpl36 Rps13 Psmb6 Rpl37 Rps4x-ps13 Rpl38 Rps3a Psmb1 Rpl39 Rps27l Psmb3 Rpl8 Rps9 Psmb2 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Ube2d1 Rpl7 Rps26-ps13 Psma7 Rpl30 LOC134486107 Rpl31 Rpl32 Psmc5 Psmc2 Rpl34 Psmc1 Rpl36al1 Psmc4 Psmc3 Rpl39l1 Rchy1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Ubb Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Psmb6l1 Rps24 Ascc3 Rpl23 Ascc2 Psmd7 Nemf Psmd6 Fau Zfp598 Psmd8 Psmd2 LOC120097744 Psmd1 Adrm1 Rbx1 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Klhdc10 Rps6 Hbs1l LOC100910714 OAS ANTIVIRAL RESPONSE%REACTOME%R-RNO-8983711.1 OAS antiviral response Oasl Rig1 Rnasel Pde12 CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence Suz12 Eed Ep400 Asf1a Cabin1 Rbbp4 Hira Rbbp7 Ubn1 Hmga2 Hmga1 Map3k5 Tnik Mink1 Map4k4 Mapk3 Mapk9 Mapk7 Mapk8 Mre11 Kat5 Nbn Fos Rps6ka3 Rps6ka1 Rps6ka2 Map2k7 Map2k6 Tp53 Txn Mapkapk3 Mapk14 H2ab2 Jun Mapkapk2 Atm H2ac4 H1-1 H1-0 Map2k3 H1-5 H1-4 H4f3 Ring1 Mapk10 Mapk11 ENSRNOG00000066901 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Rad50 Ehmt1 Cdk6 Kdm6b H2ac18 Bmi1 Hist1h2bq Terf2 Acd Terf1 H2aj Terf2ip Tinf2 Pot1 Ccna1 H3-3b Ccna2 Ube2s Hist3h2ba Rnf2 ENSRNOG00000068602 Ccne1 Rps27a Ccne2 Ube2c Cdkn2b Lmnb1 Cdkn2d Cdc27 H2bc18 Cdc26 Cdc23 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Uba52 Anapc10 Ube2d1 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Erf Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Cebpb Cdkn1b Rb1 Id1 Ets1 Ets2 Cdk2 Cdc16 Mapk1 Mdm4 Cdk4 Mapkapk5 Ezh2 FLT3 SIGNALING%REACTOME%R-RNO-9607240.1 FLT3 Signaling Pik3ca Gab2 Akt3 Akt2 Akt1 Pik3r1 Nras Grb2 Kras Sos1 Hras Grb10 Flt3 Foxo3 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation Kin Mettl21a Eef2kmt Eef1akmt2 Camkmt Eef1akmt1 Hspa8 Eef1a1 Eef2 Calm3 Prmt3 Rps2 Etfb Mettl22 Etfbkmt CHAHP COMPLEX ASSEMBLY%REACTOME%R-RNO-9940465.1 ChAHP complex assembly Chd4 Cbx3 Adnp Cbx1 DAP12 SIGNALING%REACTOME%R-RNO-2424491.1 DAP12 signaling Klrd1 Klrc2 Klrk1 Klrc1 Tyrobp Syk Plcg1 Trem2 B2m Lck Plcg2 Grap2 Pik3ca Shc1 Rac1 Pik3r1 Pik3cb Nras Vav3 Grb2 Pik3r2 Fyn Btk Kras Vav2 Sos1 Hras Lat Lcp2 KINESINS%REACTOME DATABASE ID RELEASE 96%10224083 Kinesins Klc1 Kif20b Kifap3 Klc4 Klc3 Klc2 Kif3b Kif3c Racgap1 Kif18b Kif19 Kif26b Kifc1 Kifc2 Kif3a Kif26a Kif11 Cenpe Kif12 Kif15 Kif5a Kif5b Kif21a Kif1c Kif2a Kif2b Kif21b Kif2c Kif13b Kif1a Kif4b Kif1b Kif6 Kif4a Kif9 Kif22 Kif23 Kif28 Kif27 Kif16b Kif18a Kif20a REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%10223385 Regulation of thyroid hormone activity Dio1 Dio2 Dio3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%10222825 Toll Like Receptor 7 8 (TLR7 8) Cascade Ppp2cb Ppp2ca Tasl Irf5 Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Slc15a4 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Tlr7 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Ly96 Mapk11 Ticam2 Irf7 Ticam1 Cd14 Tlr4 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-RNO-430039.1 mRNA decay by 5' to 3' exoribonuclease Dcp1b Dcp2 Lsm3 Patl1 Lsm5 Edc3 Edc4 Lsm1 Lsm6 Ddx6 Lsm7 Dcp1a FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223099 FGFR1 ligand binding and activation Fgf17 Tgfbr3 Gipc1 Fgf10 Fgf2 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%10222849 Toll Like Receptor 3 (TLR3) Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Rps6ka1 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Irf7 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%10222821 MyD88 dependent cascade initiated on endosome Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Ly96 Mapk11 Ticam2 Irf7 Ticam1 Cd14 Tlr4 RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs Ywhag Rhoc Ppp1r12a Hist1h2ai Ncoa2 Ppp1r14a Pdpk1 Ppp1cb H2ac18 Hist1h2bq Pkn2 Pkn1 Ywhae H2aj Kdm4c Rac1 H2ab2 Rhob Cdc25c H3-3b Hist3h2ba H2ac4 Rhoa ENSRNOG00000068602 H2bc18 Ywhaq Ywhah ENSRNOG00000066901 H2az2 Ar Sfn Ywhab H2bc4 Hist1h4m Kdm1a H2bc1 Ppp1r12b Ywhaz NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%10222163 Nucleotide salvage Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Adk Tymp Gmpr Hprt1 Dck Upp1 Aprt Upp2 Ada Cda Pudp Tk2 Uck1 Uck2 Dguok TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 96%10222831 Toll Like Receptor 2 (TLR2) Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%10223507 Chemokine receptors bind chemokines Cxcl9 Ccl7 Ccl5 Ccl4 Ccrl2 Cxcr1 Ccl3 Cxcr2 Ccl1 Xcr1 Cxcr3 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Cxcr4 Cxcr5 Cxcl16 Ackr3 Cxcl13 Ackr4 Ccl19 Ccl17 Ackr2 Ccl11 Ccl12 Cxcl11 Cxcl12 Pf4 Cx3cl1 Cxcl10 Ccr9 Ccr8 Ccr7 Ccr6 Cx3cr1 Ccr5 Ccl27 Ccr4 Ppbp Ccr3 Xcl1 Ccl20 Ccr10 Ccl21 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME DATABASE ID RELEASE 96%10222631 Amplification of signal from the kinetochores Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Ppp2r5b Dync1h1 Ppp2r5a Spc24 Spc25 Xpo1 Nuf2 Mad2l1 Cdca8 Incenp Dync1i2 Bub1b Ndel1 Ppp1cc Dync1i1 Cenpc Cenpa Aurkb B9d2 Ppp2r5e Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%10223589 ATF6 (ATF6-alpha) activates chaperones Atf6 Mbtps1 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%10222507 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Pdpk1 Prkaca Prkacb Gna11 Rictor Prkar1a Prr5 Prkar1b Calm3 Adm Gng3 Mapkap1 P2ry2 Gng5 Pkn2 Gng4 Gnaq Gng7 Capn2 Gng8 Gngt1 Vcl Prkar2a Prkar2b Mtor Capns1 Akt1 Gnb2 Gnb1 Gnb4 Gnb3 Nos3 Gnb5 Trpv4 Ramp2 Gng11 Gng10-ps1 Gnas Mlst8 Calcrl DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%10221963 DNA Damage Telomere Stress Induced Senescence Hist1h2ai Mre11 Kat5 Ep400 Rad50 Nbn Asf1a Cabin1 Hira Ubn1 H2ac18 Hmga2 Hmga1 Hist1h2bq Terf2 Tp53 Acd Terf1 Cdkn1b Rb1 H2aj Terf2ip Tinf2 H2ab2 Pot1 Ccna1 Ccna2 Hist3h2ba Cdk2 Atm H2ac4 ENSRNOG00000068602 H1-1 H1-0 Ccne1 H1-5 Ccne2 H1-4 H4f3 Lmnb1 ENSRNOG00000066901 H2az2 H2bc4 Hist1h4m H2bc1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 96%10222911 TGF-beta receptor signaling activates SMADs Tgfb2 Tgfb3 Ltbp3 Ltbp2 Tgfbr3 Mtmr4 Uba52 Furin Ltbp4 Tgfbr1 Tgfbr2 Ltbp1 Strap Bambi Ube2m Itgb8 Itgb6 Nedd8 Itgb1 Itgb3 Ubb Ubc Fkbp1a Smad2 Smad3 Smad4 Smad7 Cbl Stub1 Zfyve9 Rps27a Itga8 Itgav Smurf2 Tgfb1 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-RNO-69601.1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Fbxw11 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Chek1 Psmc3 Chek2 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Mapk14 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Mapk11 Skp1 Psmb5 Plk3 Psmb4 Csnk1e Psmb7 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 96%10222983 Cobalamin (Cbl) metabolism Mtr Mmachc Mmadhc Mmut Mmaa Mtrr Mmab N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%10224067 N-glycan antennae elongation in the medial trans-Golgi St8sia6 Mgat4c Mgat4b B4galt2 B4galt3 Chst10 St3gal4 B4galt4 B4galt5 B4galt6 St6gal1 Mgat5 Fut8 Fuca1 Mgat4a Man2a1 Mgat3 St8sia2 Man2a2 St8sia3 Mgat2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange Mre11 Xrcc2 Kat5 Rad51 Rad50 Nbn Atm Rad51c Rad51b Exo1 Chek1 Rbbp8 Rmi2 Brca2 Rmi1 Brca1 Blm Brip1 Bard1 Wrn Top3a Dna2 MUSCLE CONTRACTION%REACTOME%R-RNO-397014.1 Muscle contraction Prkaca Tln1 Cacna1c Calm3 Kcna5 Akap9 Kcne5 Kcnq1 Kcne4 Myl12b Kcne3 Pxn Kcne2 Kcnh2 Myl10 Cacnb1 Pde5a Gucy1b1 Itpr3 Cacnb2 Tmod1 Gucy1b2 Itpr2 Tmod4 Itpr1 Pak1 Tmod2 Itga1 Kcnj4 Cacng4 Tnni2 Atp2a1 Lmod1 Tnni1 Cacna2d2 Pak2 Tpm4 Myl4 Kcnj2 Atp2a3 Tpm2 Myl1 Atp2a2 Myl2 Cald1 Kcnj14 Tpm1 Myl3 Neb Rlc-a Kcnj11 Mylk Tnnt3 Kcnj12 Abcc9 Gucy1a1 Tnnt2 Gucy1a2 Tnnt1 Myl7 Tnnc2 Myl11 Tnnc1 Myl9 Atp2b1 Myh3 Camk2g Dmd Sorbs3 Atp2b4 Actn3 Camk2d Atp2b3 Myh6 Camk2b Tcap Des Mybpc2 Mybpc3 Actn2 Sri Camk2a Atp1b1 Atp1b3 Atp1b2 Ryr2 Ryr1 Fkbp1b Dmpk Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Ahcyl1 Pln Asph Trpc1 Stim1 Tnni3 Cacng8 Vcl Mme Ces1d Slc8a1 Slc8a2 Slc8a3 Tmod3 Nos1 Kcnk4 Kcnk2 Kcnk1 Kcnk10 Kcnk16 Kcnk9 Kcnk7 Kcnk18 Kcnk6 Cacng6 Cacng7 Kcnd3 Kcnd2 Kcnd1 Kcnip3 Kcnip4 Kcnip1 Kcnip2 Vim Kcnk12 Kcnk15 Npr1 Npr2 Kcnk5 Corin Nppc Nppa Kcnk13 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 96%10222901 Activation of GABAB receptors Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Gng3 Gnal Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Gnat3 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 96%10225317 Amino acids regulate mTORC1 Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6v1e2 Sesn2 Atp6v1e1 Tcirg1 Sesn1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Nprl3 Nprl2 Wdr59 Mios Depdc5 Wdr24 Lamtor3 Fnip1 Lamtor2 Fnip2 Samtor Rptor RragB Itfg2 Castor2 Castor1 Mtor Sec13 Rheb Szt2 Slc38a9 Lamtor5 Lamtor4 Kics2 Rraga Flcn Lamtor1 Rragc Sh3bp4 Rragd Mlst8 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%10222741 Asparagine N-linked glycosylation Srd5a3 Fut8 Fuca1 Man2a1 Man2a2 Mgat2 Dpm2 Spta1 Sptb Sptbn1 Sptbn2 Sptan1 Gmppa Alg9 Pmm2 Sptbn5 Alg8 Mpi Alg6 Pmm1 Alg3 Sptbn4 Sar1b Alg2 Alg13 Alg14 Alg12 Mpdu1 Dpagt1 Tgfa Areg Nagk Gnpnat1 Amdhd2 Uap1 Gfpt1 Gfpt2 Pgm3 Renbp Amfr Engase Ngly1 B4galt4 B4galt5 B4galt6 B4galt2 B4galt3 Rps27a Rab1b Trappc2l Uba52 Trappc10 Psmc1 Mgat5 Ubb Mgat1 Slc35c1 Mgat3 Ubc Manea Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Trappc6b Trappc6a Trappc9 Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Ins1 Cd55 Lman1 Scfd1 Mvd Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Tmem115 Kdelr2 Kdelr3 Sec23ip Sec16b Sec16a Dpm1 Lman2l Dpm3 Copa Bet1l Rad23b Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Ppp6c Sec31b Sec31a Gria1 Umod F8 Stx17 Asgr2 Asgr1 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Calr Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Pdia3 Ankrd28 Cd59 Arcn1 Bet1 B4galnt2 Ctsz Chst10 Ubxn1 Canx Dync1h1 St8sia6 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Dync1i2 Cmas Dync1i1 St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 Dhdds St3gal6 Nudt14 St6galnac2 Alg5 St3gal4 Dolpp1 St3gal5 Fuom St3gal2 Gmds St3gal3 Dolk Slc35a1 Fcsk St3gal1 Dhrsx Nanp Nus1 St6gal1 Fpgt Glb1 St6gal2 Gfus Nans St8sia2 Mgat4a St8sia3 St8sia1 Ctsa Gne Sec13 Dync1li2 Vcp Dync1li1 Dynll1 Dynll2 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-RNO-446388.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Arhgef6 Pxn Parvb Parva Actn1 Tesk1 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-RNO-1480926.1 O2 CO2 exchange in erythrocytes Cyb5r1 Slc4a1 Aqp1 Ca1 Ca2 Cyb5r4 Ca4 Cyb5r2 Hba1 Cyb5rl Hbb Rhag ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 96%10222899 Adenylate cyclase inhibitory pathway Adcy5 Adcy6 Gnat3 Adcy9 Gnai2 Gnai1 Gnai3 Adcy3 Adcy4 Gnal Adcy1 Adcy2 Adcy7 Adcy8 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-RNO-4570464.1 SUMOylation of RNA binding proteins Phc1 Nup133 Sumo3 Cbx4 Nup210 Nup155 Nup153 Cbx2 Ube2i Phc3 Pcgf2 Bmi1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Rnf2 Nup160 Rae1 Ndc1 Hnrnpc Nup85 Nup42 Hnrnpk Nup62 Ring1 Nup43 Nup88 Aaas Phc2 Nop58 Ranbp2 Sumo1 Nup214 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224677 Phase 1 - inactivation of fast Na+ channels Kcnd3 Kcnd2 Kcnd1 Kcnip3 Kcnip4 Kcnip1 Kcnip2 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%10222415 Developmental Biology Erbb2 Gsk3b Frs2 Prkcq Ranbp9 Tln1 Rasa1 Fgfr1 Creb1 Ret Spta1 Col4a1 Ptpra Col4a2 Stx1a Ncam1 Sptb Sptbn1 Sptbn2 Mark3 Ptk2 Sema5a Mapk3 Sptan1 Sptbn5 Artn Rps6ka5 Nras Gfra1 Sptbn4 Grb2 Gfra2 Fyn Gfra4 Kras Sos1 Hras Mapk7 Kit Tnfsf11 Kitlg Map2k2 Map2k1 Rps6ka1 Cacng8 Egfr Cacng3 Shc3 Mapk14 Pspn Dcc Gdnf Pkp1 Dpysl2 Dsc1 Kif4b Ap2s1 Kif4a Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Nrtn Numb Sh3gl2 Mapk11 Ezr Itgav Itga2b Met Mapk12 Itgb1 Grb10 Itgb3 Akt3 Akt2 Akt1 Sh3kbp1 Dok1 Itga9 Rab27a Pak1 Pak2 Lyn Yes1 Src Rlc-a Rhoa Ngef Dlg4 Grin1 Grin2b Ube2i Reln Dab1 Cdh2 Rhob Sirt1 Sumo1 Myog Myod1 Mef2d Boc Ctnna2 Bnip2 Spag9 Dok2 Mef2a Mef2b Mef2c Myf6 Tcf4 Myf5 Qars1 Lars1 Rars1 Kars1 Myo5a Sox10 Aimp2 Eprs1 Iars1 Tbx3 Cdh15 Mars1 Myrip Sytl2 Dars1 Pik3ca Shc1 Gab2 Farp2 Pip5k1c Csf1 Pik3r1 Pik3cb Pik3r2 Pik3r3 Hint1 Mitf Pik3cd Gab1 Pparg Irs2 Xpo1 Vldlr Klk13 Cdon Ctnnb1 Tcf7 Tcf7l1 Tcf7l2 Cacng4 Cacng2 Ptprc Stx1b Lgi2 Sdc2 Lgi3 Lgi4 Cdsn Lgi1 Klk5 Adam23 Adam11 Kazn Klk8 Adam22 Sprr3 Lef1 Tgm1 Stfa2l3 Casp14 Evpl Spink6 Cela2a Spink5 Perp Klk12 Pkp2 Arpc3 Pkp3 Arpc2 Dsg3 Lipk Sema4d Dsg4 Plxnb1 Dsc2 Arpc5 Ctnna1 Arpc4 Rptn Lipm Klk14 Dsc3 Dnm2 Jup Lipn Dsp Nrp1 Dsg1 Dsg2 Efna1 Efna2 Epha1 Epha3 Hsp90ab1 Epha4 Epha5 Epha6 Epha7 Epha10 Efna4 Efna5 Ppl Arpc1b Actr2 Arpc1a Actr3 Arhgef28 Krt1 Rhoc Cd72 Plxnb3 Sema6d Crmp1 Plxna4 Shank3 Myo9b Plxna3 Plxna2 Rras Tyrobp Plcg1 Sema4a Dpysl3 Dpysl4 Dpysl5 Arhgap35 Plxnc1 Sema3a Sema7a Fes Trem2 Sema3e Plxna1 Sdcbp Efnb1 Rock2 Arhgef7 Rock1 Efnb2 Efnb3 Ephb1 Plxnd1 Dscaml1 Ephb2 Ntn4 Ephb3 Ephb4 Dscam Ephb6 Unc5a Nck2 Rac1 Pak3 Rnd1 Git1 Hsp90aa1 Limk1 Rxra Nck1 Actb Hdac3 Rara Foxo3 Mmp2 Mmp9 Ncor2 Cdk2 Lypla2 Gap43 Mapk1 Grb7 Prkaca Prkacb Pdlim7 Dok4 Dok5 Prkca Dok6 Cdk5r1 Ank1 Smad2 Cdk5 Smad3 Smad4 Nfasc Krtap24-1 Krtap13-1 Krtap10-9 LOC120093742 Krtap11-1 Adgrg6 Krtap31-2 Krtap31-1 Krt33b Krt33a Epha2 Cebpa Krtap2-4l1 Krtap3-1 Krt4 Krt2 Krtap3-2 Krt8 Krt7 Krt5 Krt9 LOC680428 Krt27 Krt28 Krt25 Krt26 Krtap29-1 Krt24 Krt20 LOC134481131 LOC102553726 Krtap5-8 Krt39 Krt36 Krt34 Krt35 Krt32 Krt31 AABR07001416.1 Krtap6-5 Krt18 Krt19 Krt17 Krt14 Krt15 Krt12 Krt13 Krt10 Krtap16-5 Krtap16-1 Krt6a Krt71 Krt78 Krt76 Krt77 Krt75 Krt72 Krt73 Krt40 Krtap1-3 Abl1 Krtap1-1 Krtap1-5 LOC134478810 Krt82 Krt80 Krt85 Krt86 Rap1gap Krt83 Krt84 LOC102551497 Crebbp Tcf3 Sin3a Csnk2a2 Csnk2a1 Actg1 Hdac1 Csnk2b Tfap2c Tiam1 Tfap2a Tfap2b Ep300 Arhgef11 Arhgef12 Vav3 Tcf12 Vav2 Itsn1 Ptpn11 Psenen Psen1 Psen2 Kalrn Ncstn Aph1a Aph1b St8sia4 Trio St8sia2 Ap2m1 Clta Cltc Dnm1 Foxo1 Cdc42 Cdk4 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-RNO-8964616.1 G beta:gamma signalling through CDC42 Arhgef6 Gng7 Gng8 Gngt1 Pak1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Gng3 Cdc42 Gng5 Gng4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B Ccnb1 Uba52 Anapc10 Ube2d1 Anapc16 Ube2s Cdc16 Anapc15 Cdk1 Rps27a Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Ubb Anapc7 Cdc20 Ubc Ube2e1 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 96%10225077 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Cbfb Runx1 Foxp3 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane Gjb2 Gja1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%10225045 Carboxyterminal post-translational modifications of tubulin Ttll6 Ttll7 Ttll4 Ttll5 Ttll10 Ttll2 Ttll3 Ttll11 Ttll12 Ttll8 Ttll13 Ttll9 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-RNO-1971475.1 Glycosaminoglycan-protein linkage region biosynthesis Gpc1 Gpc3 Gpc2 Gpc5 Cspg5 Gpc4 Bgn Cspg4 Gpc6 B3galt6 Fam20b B4galt7 Pxylp1 Sdc1 Xylt1 Xylt2 Bcan Vcan Agrn Ncan Dcn Sdc4 Sdc3 Sdc2 Uxs1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 96%10223027 PI-3K cascade:FGFR2 Fgf16 Fgf17 Pik3ca Fgf18 Frs2 Fgf10 Pik3r1 Grb2 Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Gab1 Fgfr2 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 96%10222719 Gamma-carboxylation of protein precursors Pros1 F10 F7 F9 Ggcx Bglap F2 Proc Proz FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-RNO-9614085.1 FOXO-mediated transcription Ywhag Foxo4 Crebbp Smad2 Smad3 Foxo6 Smad4 Akt3 Akt2 Akt1 Ep300 Foxo1 Foxg1 Sirt3 Sirt1 Atxn3 Ywhaq Kat2b Sfn Ywhab Foxo3 Ywhaz REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-RNO-9614399.1 Regulation of localization of FOXO transcription factors Ywhag Foxo1 Foxo4 Ywhaq Foxo6 Akt3 Akt2 Sfn Ywhab Akt1 Foxo3 Ywhaz BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-RNO-9018677.1 Biosynthesis of DHA-derived SPMs Alox12 Cyp3a9 Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp3a2 Ptgs2 Gstm4 Ltc4s PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%10224351 Pre-NOTCH Expression and Processing Tmed2 Prkci Notch4 Elf3 Notch3 GALACTOSE CATABOLISM%REACTOME%R-RNO-70370.1 Galactose catabolism Galt Galm Galk1 Pgm1 Gale FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%10222671 FXIIa, PKa activate coagulation factors Kng1 F12 F11 F9 Gp5 Gp9 Gp1bb Gp1ba Klkb1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10222273 Organic anion transport by SLC5 17 25 transporters Slc25a10 Slc5a8 Slc25a1 Slc5a12 Slc25a11 Slc17a5 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-RNO-434313.1 Intracellular metabolism of fatty acids regulates insulin secretion Cd36 Acsl3 Acsl4 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%10224605 SUMOylation of DNA replication proteins Nup133 Sumo3 Nup210 Nup155 Pias4 Nup153 Ube2i Cdca8 Incenp Aurkb Top2b Top2a Top1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Rangap1 Nup37 Pom121 Sumo2 Nup205 Nup107 Pcna Nup188 Tpr Nup160 Rae1 Ndc1 Pias3 Nup85 Nup42 Nup62 Nup43 Nup88 Birc5 Aaas Ranbp2 Sumo1 Nup214 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-RNO-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Bcl11b Smarcc1 Phf10 Smarca2 Smarca4 Arid1a Arid1b Actl6a Smarcd1 Ss18 Smarce1 Smarcd3 Smarcd2 Dpf2 Actg1 Bcl7a Smarcb1 Bcl7b Bcl7c Bcl11a INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223887 Interleukin-33 signaling Il1rap Il1rl1 Il33 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%10222985 Cobalamin (Cbl, vitamin B12) transport and metabolism Ldlrap1 Mtr Mmachc Mmadhc Lrpl1 Abcc1 Amn Cblif Tcn2 Mmut Mmaa Cubn Mtrr Mmab Lrp2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 96%10224185 TWIK related potassium channel (TREK) Kcnk4 Kcnk2 Kcnk10 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-5632681.1 Ligand-receptor interactions Cdon Dhh Ptch1 Hhip Ihh Shh INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling Il23a P4hb Jak2 Il23r Tyk2 Stat3 Il12rb1 Il12b DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224213 Downregulation of ERBB2 signaling Erbb2 Erbb3 Ereg Uba52 Ptpn12 Nrg2 Nrg3 Btc Egf Cul5 Ubb Ubc Ptpn18 Usp8 Ptk7 Egfr Rnf41 Akt3 Hbegf Akt2 Akt1 Hsp90aa1 Stub1 Rps27a Cdc37 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 96%10222919 Signaling by Activin Tgfbr3 Inha Smad2 Smad3 Smad4 Mapk3 Inhba Inhbb Fstl3 Mapk1 Fst Acvr1c Acvr1b Acvr2b Acvr2a FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-RNO-5654700.1 FRS-mediated FGFR2 signaling Frs2 Frs3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Fgfr2 Fgf16 Fgf17 Fgf18 Fgf10 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Fgf22 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%10223455 Insulin processing Exoc3 Exoc4 Exoc5 Ero1b Exoc6 Ins2 Exoc1 Exoc2 Exoc7 Exoc8 Slc30a5 Slc30a8 P4hb Ins1 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%10223515 Ligand-independent caspase activation via DCC Casp3 Casp9 Dcc Appl1 PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase Kcne3 Kcne2 Cacng8 Cacnb1 Cacnb2 Cacng4 Cacna2d2 Cacna1c Cacng6 Cacng7 Akap9 Kcne5 Kcnq1 Kcne4 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 Csnk2b Egfr Ncam1 Pak1 Rac1 Itga2b Mapk3 Map2k2 Map2k1 Mapk1 Csnk2a2 L1cam Vav2 Nrp1 Csnk2a1 Itgb1 Itgb3 Itgav Itga9 Fgfr1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223843 Zinc transporters Slc30a1 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc30a5 Slc39a8 Slc30a8 Slc39a7 Slc39a6 Slc39a14 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%10222607 COX reactions Ptgs1 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224097 Potassium Channels Kcna10 Kcna2 Kcnb1 Kcns3 Kcnc4 Kcna1 Kcnc2 Kcnc3 Kcng2 Kcnc1 Kcng4 Kcng3 Kcng1 Kcnh1 Kcnv2 Kcnv1 Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Gng3 Kcnn2 Hcn3 Kcna5 Hcn4 Kcnma1 Gng5 Gng4 Hcn1 Kcnq1 Hcn2 Gabbr1 Gng7 Kcnh2 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj8 Kcnj6 Kcnk4 Kcnj5 Kcnk2 Kcnj4 Kcnk1 Kcnj3 Kcnk10 Kcnk16 Kcnj10 Kcnj2 Kcnk9 Kcnj1 Kcnk7 Kcnk18 Kcnj14 Gnb2 Abcc8 Kcnk6 Gnb1 Kcnj11 Kcnj12 Gnb4 Abcc9 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Kcnd3 Kcnd2 Kcnd1 Kcnab2 Kcnb2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnf1 Kcnh3 Kcnq5 Gng10-ps1 Kcnk13 Kcnab1 Kcns2 Kcns1 Kcnab3 Kcna7 Kcna6 Kcna4 Kcna3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 96%10222347 Beta oxidation of hexanoyl-CoA to butanoyl-CoA Hadha Hadhb Echs1 Hadh Acads INTERLEUKIN-10 SIGNALING%REACTOME%R-RNO-6783783.1 Interleukin-10 signaling Il10 Tyk2 Stat3 Il10rb Il10ra ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism Adh1 Nt5c2 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-RNO-2187335.1 The retinoid cycle in cones (daylight vision) Opn1mw Rlbp1 Awat2 Opn1sw Dhrs3 Rbp3 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%10222331 Eicosanoids Cyp8b1 Cyp4f39 Cyp4f1 Cyp4a14 Tbxas1 Cyp4f3 Cyp4a12 Ptgis Cyp4f40 Cyp4b1 Cyp4f4 Cyp4a10 Cyp4a2 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-RNO-450520.1 HuR (ELAVL1) binds and stabilizes mRNA Tnfsf13 Xpo1 Set Anp32a Prkcd Elavl1 Nup214 Prkca INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%10222609 Initiation of coagulation cascade F10 F3 F7 F9 F2 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225165 RAC1 GTPase cycle Vamp3 Garre1 AABR07032856.1 Nisch Nckap1l Snap23 Jag1 Pak1 Nox3 Nox1 Pak2 Amigo2 Noxa1 Emd Baiap2l1 Ngef Fgd5 Taok3 Sos1 Chn2 Esyt1 Abi2 Abi1 Iqgap2 Pak6 Pak4 Vrk2 Git2 Arhgap12 Abl2 Epha2 Slc1a5 Srgap1 Ncf1 Arhgap45 Ncf2 Ykt6 Ncf4 Brk1 Bcr Arhgap5 Arhgap15 Arhgap4 Arhgap17 Arhgap1 Arap1 Arap3 Arap2 Arhgap25 Arhgap9 Arhgap27 Mcam Pld1 Arhgap33 Wasf3 Wasf2 Wasf1 Plekhg1 Ralbp1 Cdc42bpa Pard6a Arhgdib Gmip Arhgap10 Iqgap3 Fermt2 Diaph3 Rasgrf2 Depdc1b Cit Fam13a Arhgap22 Nckap1 Arhgap21 Arhgap20 Arhgap26 Cyfip2 Arhgap24 Cyfip1 Arhgap23 Arhgap29 Ophn1 Dock2 Def6 Fam13b Myo9b Pak5 Arhgap31 Arhgap30 Prex2 Noxo1 Arhgap35 Mpp7 Cyba Srgap2 Cybb Tagap Srgap3 Racgap1 Plekhg6 Cdc42ep1 Plekhg3 Cdc42ep4 Itgb1 Ktn1 Farp1 Syde2 Dlc1 Pld2 Pkn2 Arhgef7 Pkn1 Arhgap44 Arhgap42 Pik3ca Spata13 Tiam1 Arhgap32 Mcf2l Tiam2 Cav1 Rac1 Pak3 Swap70 Git1 Farp2 Arhgef15 Baiap2 Arhgef11 Pik3r1 Arhgef10 Arhgef19 Vav3 Dock5 Pik3r2 Dock6 Pik3r3 Vav1 Vav2 Dock3 Dock4 Dock7 Tfrc Arhgef25 Dock8 Fmnl1 Sh3bp1 Sos2 Kalrn Arhgef6 Arhgef5 Arhgef4 Gna13 Abr Dock10 Dock11 Arhgef39 Ect2 Prex1 Trio Plekhg2 Rab7a Lamtor1 Lbr Cdc42 Mcf2 Arhgdia Als2 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%10222017 Glucuronidation Ugt1a2 Ugt1a1 Ugt1a3 Ugt1a5 Ugt2b1 Ugt1a6 Ugt1a7 Slc35d1 Ugt2b7 Ugt1a8 AC114845.1 Ugt2b34l1 Ugt2b Ugt2a1 Ugt2a3 Uxs1 Ugt2b17 Ugt2b37 Ugp2 Ugt2b15 Ugdh Ugt3a1 Abhd10 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%10222197 Programmed Cell Death Ywhag Apip Casp7 Apaf1 Diablol1 Ctnnb1 Prkcq Prkcd Septin4 Bak1 Nmt1 Gzmb Bid Xiap Gsn Casp6 Gas2 Sh3glb2 Add1 Il1a Il1b Mlkl Flot2 Flot1 Ptk2 Mapk3 Ripk3 Tradd Sptan1 Cflar Prkn Stub1 Ripk1 Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Bcl2l1 Acin1 Ube2l3 Bmf Mapk8 Opa1 Oma1 Peli1 Gsdme Gsdmd Apc Traf2 Tjp1 Dsg3 Cdh1 Il18 Dsp Dsg1 Dsg2 Kpnb1 Hmgb1-ps34 Ppp3r1 Kpna1 Clspn Casp8 Chmp2b Cycsl2 Dcc Appl1 Chmp3 Pkp1 Hmgb1l2 Chmp7 Hmgb1l1 H1-1 Chmp6 Lmna H1-0 H1-5 H1-4 H4f3 Hmgb2 Fnta Chmp4c Dffa Chmp4bl1 Dffb Cycs Ywhab Ocln Birc2 Bax Plec Bcap31 Satb1 Sdcbp Rock1 Tjp2 Elane Bcl2l11 Stk26 Stk24 Dnm1l Hsp90aa1 Itch Rps27a Lmnb1 Sfn Vim Chmp2a Uba52 Mapt Ppp3cc Pmaip1 Bad Casp3 Casp9 Ubb Ogt Ubc Casp1 Ywhae Mapk1 Bmx Dynll1 Dynll2 Ywhaq Ywhah Ly96 Ticam2 Ticam1 Cd14 Tlr4 Ywhaz P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA Damage Checkpoint Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Fbxw11 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Chek1 Psmc3 Chek2 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Mapk14 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Mapk11 Skp1 Psmb5 Plk3 Psmb4 Csnk1e Psmb7 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 96%10225471 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Sin3a Lef1 Hint1 Tcf7l1 Tcf7l2 Ctnnb1 Hdac1 Tcf7 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%10222059 Transmission across Chemical Synapses Gls2 Cacnb3 Cacnb4 Creb1 Cacnb1 Cacna1e Cacnb2 Stx1a Cacna1a Cacna1b Cacna2d3 Cacng4 Cacna2d2 Cacng2 Vamp2 Lin7b Rps6ka3 Rps6ka1 Rps6ka2 Cacng8 Cacng3 Chrnb4 Chrnb3 Chrnb2 Grip2 Prkcb Epb41l1 Gabrg2 Gabrg3 Grin3a Chrna3 Chrna2 Ap2s1 Chrna1 Chrna7 Grik5 Chrna6 Chrna5 Chrna4 Grik4 Ap2a2 Ap2a1 Chrna9 Grik3 Ap2b1 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabra2 Gabra1 Akap5 Glra3 Glra2 Glra1 Rps6ka6 Tspan7 Camk1 Glrb Ncald Grip1 Chrnd Gabrr1 Chrne Gabrr3 Gabrr2 Chrng Gabrq Gabrb1 Gabrb3 Slc18a3 Gabrb2 Htr3b Htr3a Gabbr1 Gabbr2 Dnajc5 Hspa8 Rab3a Slc5a7 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Adcy5 Adcy6 Tomt Adcy9 Prkaca Prkacb Prkcg Gnai2 Gnai1 Prkca Slc1a1 Gnai3 Camk4 Prkar1a Slc38a2 Prkar1b Slc1a7 Calm3 Slc1a6 Nsf Gng3 Gnal Gng5 Slc6a12 Gng4 Gng7 Gng8 Gngt1 Kcnj9 Gnat3 Prkar2a Kcnj6 Prkar2b Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Gnb4 Kcnj12 Grin2a Gnb3 Lrrc7 Gnb5 Kcnj15 Gng11 Gria4 Kcnj16 Slc22a2 Gria3 Camk2g Camk2d Slc22a1 Gria2 Slc32a1 Camk2b Dlg1 Dlg2 Gria1 Actn2 Slc6a11 Dlg3 Slc6a13 Dlg4 Camk2a Nefl Grin1 Aldh5a1 Grik2 Grin2d Grik1 Grin2c Slc17a7 Naaa Abat Grin2b Slc6a1 Syn3 Slc6a4 Syn2 Slc6a3 Syn1 Cask Chat Lin7a Lin7c Gad1 Gad2 Apba1 Arl6ip5 Rims1 Maoa Tspoap1 Syt1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Aldh2 Arhgef9 Gls Slc38a1 Ap2m1 Slc1a3 Slc1a2 Glul Myo6 Comt GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%10222013 Glycolysis Aldoa Nup133 Pfkl Nup210 Nup155 Pgk2 Nup153 Pfkm Pfkp Pgm2l1 Pkml1 Gck Hk2 Hk3 Adpgk Tpi1l2 Aldob Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Gnpda1 Gpi Nup205 Gnpda2 Nup107 Eno3 Sec13 Eno2 Eno4 Nup188 Pfkfb4 Tpr Pfkfb3 Pfkfb2 Nup160 Pgk1 Pfkfb1 Rae1 Pgam2 Ndc1 Pgam1 Tpi1 Nup85 Nup42 Nup62 Hkdc1 Nup43 Nup88 Gckr Aaas Pklr Ranbp2 Gapdhs Aldoc Nup214 Bpgm LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 96%10224381 Linoleic acid (LA) metabolism Fads1 Elovl2 Elovl3 Abcd1 Elovl5 Elovl1 Acsl1 Fads2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 96%10224505 SUMOylation of DNA damage response and repair proteins Nsmce1 Phc1 Nup133 Sumo3 Nsmce2 Cbx4 Nup210 Nup155 Xpc Nup153 Cbx2 Stag2 Phc3 Stag1 Rad52 Mageb10 Sp100 Pcgf2 Bmi1 Brca1 Smc1a Sumo2 Rnf2 Tdg Blm Pml Pias4 Ube2i Rpa1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Parp1 Nup37 Pom121 Nup205 Nup107 Sec13 Xrcc4 Nup188 Tpr Nup160 Rae1 Smc6 Smc5 Ndc1 Smc3 Nup85 Sp140 Nup42 Pias1 Nup62 Pias2 Nup43 Ring1 Nsmce4a Nup88 Aaas Eid3 Herc2 Ranbp2 Rnf168 Phc2 Sumo1 Cetn2 Nup214 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%10222055 Astrocytic Glutamate-Glutamine Uptake And Metabolism Glul Slc38a1 Slc1a3 Slc1a2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%10223467 ABC transporters in lipid homeostasis Abca9 Abca7 Abcd1 Abcd2 Abcd3 Apoa1 Abcg4 Abcg8 Abcg5 Abca3 Pex19 Abca12 Abca2 Abca5 Pex3 Abca6 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%10224499 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Ube2i Uba2 Rwdd2b Sae1 Sumo1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling Fyn Trio Rac1 Cdc42 Dcc Ptk2 Nck1 Src GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 96%10222107 Glycogen breakdown (glycogenolysis) Phkg1 Gaa Phkg2 Agl Pygl Pygm Phkb Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Calm3 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%10225371 Regulation of NF-kappa B signaling N4bp1 Ikbkg Casp8 Uba52 Lrrc14 Traf2 Nlrx1 Rps27a Usp14 Usp18 Nlrc5 Chuk Ikbkb Ubb Ubc Traf6 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 96%10221923 G1 S Transition Ppp2cb Ccnd1 Ppp2ca Cdk7 Mnat1 Ppp2r1b Psma4 Ppp2r1a Ccna1 Psma3 Akt3 Ccna2 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Ppp2r3b Psmd11 Psmd14 Psmd13 Cdc25a Orc4 Orc6 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Ptk6 Psmb7 Cdc7 Psmb6 Cdc6 Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Cks1b Cables1 Psma7 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Pole4 Rpa1 Rpa2 Wee1 Ubb Rpa3 Ubc Psmb6l1 Cdkn1b Psmd7 Pole Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Pola2 Cul1 Ccnh Cdk2 Pola1 Prim2 Prim1 Cdk4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Cilp Pdpk1 Frs2 Trib3 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Shc1 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Pik3r2 Grb2 Sos1 Ptpn11 Fgf20 Fgf23 Fgf22 Pik3c3 Gab1 Irs2 Pik3r4 Klb Irs1 Fgf2 Fgf1 Fgf4 Igf1r Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Igf2 Igf1 Kl Flt3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 96%10225203 Biosynthesis of aspirin-triggered D-series resolvins Gpx4 Alox5 Lta4h M PHASE%REACTOME%R-RNO-68886.1 M Phase Ywhag Spdl1 Nup133 Nup210 Nup155 Bub1 Nup153 Itgb3bp Zwilch Nek9 Ctdnep1 Cnep1r1 Lpin3 Lpin2 Ofd1 Mapk3 Emd Tuba1b Ppp2r5b Ppp2r5a Vrk2 Ppp1cc Ppp2r5e Mastl Arpp19 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Kpnb1 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Tuba1c Tubal3 Nme7 Rcc1 Cep152 Tuba4a Chmp2b Tubgcp2 Cc2d1b Spast Prkcb Haus4 Tubb2b Haus5 Tubb2a Haus6 Ist1 Pcnt Sfi1 Hdac8 Chmp3 Vrk1 Haus1 Chmp7 Tubgcp6 Chmp6 Tubgcp5 Lmna Tubgcp4 Vps4a Tubgcp3 Sirt2 Cep250 Tuba8 Cep290 Cep78 Chmp4c Cep76 Tuba3b Cep72 Chmp4bl1 Tubb6 Cep164 Cep70 Tubb3 Cpap Tubb1 Tubb5 Banf1 Plk4 Ran Ankle2 Odf2 Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Kif23 Rab1b Cdc20 Psmb5 Psmb4 Psmb7 Chmp2a Kif20a Psmb6 Ppp2r2a Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Ywhae Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 Mapk1 Lbr Actr1a Ppp2cb Ppp2ca Dctn1 Dctn2 Prkaca Rab1A Prkca Ppp2r5d Akap9 Prkar2b Gorasp1 Ppp2r1b Ppp2r1a Nipbl Ncapd2 Mau2 Ncapg Smc4 Ncaph Smc2 Eml4 Wapl Numa1 Pds5b Pds5a Cdca5 Csnk1d Ccp110 Ube2i Golga2 Firrm Set H2ab2 Rab2a Blzf1 Espl1 Ncaph2 Ncapd3 Kmt5a H2ac4 Ncapg2 Gorasp2 Mcph1 Smc3 ENSRNOG00000066901 Sumo1 Stag2 Stag1 H2ac18 Phf8 Csnk2a2 Csnk2a1 Hist1h2bq Smc1a Csnk2b H2aj Hist3h2ba ENSRNOG00000068602 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint H2az2 Rps27 H2bc4 Hist1h4m Rcc2 H2bc1 Kif18a Nudc Dync1h1 Hist1h2ai Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Nup50 Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup54 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Nup58 Rangap1 Nup37 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Sec13 Kif2a Kif2b Kif2c Nup188 Dync1li2 Tpr Pmf1 Nup160 Dync1li1 Rae1 Ahctf1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Nup42 Nup62 Ndc80 Nup43 Nup88 Birc5 Aaas Ercc6l Ccnb2 Ranbp2 Ckap5 Nup214 Csnk1e BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223373 Basigin interactions Slc3a2 Ppia Atp1b1 Atp1b3 Atp1b2 Ppil2 Itgb1 Itga3 Cav1 Mmp1b Spn Slc16a3 Slc7a11 Slc16a8 Slc7a10 Slc16a1 L1cam Bsg Slc7a6 Itga6 Slc7a7 Slc7a5 Slc7a8 Mag Slc7a9 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223531 Other semaphorin interactions Plxnd1 Cd72 Plxnb3 Sema6d Tyrobp Sema5a Sema4a Ptprc Sema4d Plxnc1 Sema7a Trem2 Sema3e Plxna1 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%10224777 SHC-mediated cascade:FGFR4 Fgf16 Fgf17 Shc1 Fgf18 Fgf19 Nras Grb2 Kras Klb Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%10222763 Mitochondrial transcription termination Mterf1 PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors Corin Nppc Nppa Mme Npr1 Ces1d Npr2 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225419 Transcriptional and post-translational regulation of MITF-M expression and activity Tnfsf11 Xpo1 Gsk3b Ube2i Crebbp Kitlg Qars1 Lars1 Rars1 Kars1 Rps6ka1 Sox10 Aimp2 Eprs1 Iars1 Tbx3 Mars1 Dars1 Mark3 Akt3 Mapk3 Csf1 Ep300 Mapk1 Hint1 Mitf Sirt1 Kit Sumo1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222727 PDE3B signalling Pde3b SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism Abcg2 Abcc1 A4galt Cerk M6pr B3galnt1 Ugcg B4galnt1 Ugt8 Gal3st1 B3gnt5 Mfsd2b Sptssa Cers6 Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Aldh3a2 Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Degs1 Ormdl2 Sphk1 St8sia5 Arsa Smpd2 Neu2 Smpd3 Neu3 Smpd4 Neu4 Smpd1 Neu1 Gba1 Gba3 St6galnac5 Gba2 St6galnac6 Enpp7 Galc Asah2 Asah1 Sts Gm2a Acer1 Acer2 St3gal5 Arsl Aldh3b1 St3gal2 Arsk Sgpl1 St3gal3 Arsj Aldh3b2 Arsi Acer3 Arsg Sgpp2 Gla Plpp2 Sumf1 Plpp3 Glb1 Arsb Plpp1 Sumf2 Sgpp1 Ormdl3 Ctsa Fut2 Fut1 Cyb5b B3galt4 Glb1l Psap B4galt5 B4galt6 Glb1l3 Glb1l2 Hexa Hexb FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%10222565 Fibrin formation Fgb Fga Fgg Itga2b F13b Proc F13a1 Serpinc1 Serpine2 Serpina5 Itgb3 F2 Serpind1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation Cltc Mylip Uba52 Ap2s1 Rps27a Vldlr Ap2a2 Ap2a1 Ap2b1 Nr1h3 Pcsk9 Nr1h2 Ubb Ap2m1 Ubc Clta G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223347 G-protein beta:gamma signalling Arhgef6 Gng7 Pik3r5 Pik3cg Gng8 Gngt1 Pak1 Pdpk1 Akt3 Akt2 Gnb2 Akt1 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Pik3r6 Gng3 Cdc42 Gng5 Gng4 MITOTIC ANAPHASE%REACTOME%R-RNO-68882.1 Mitotic Anaphase Spdl1 Nup133 Nup155 Bub1 Itgb3bp Zwilch Emd Tuba1b Ppp2r5b Ppp2r5a Vrk2 Ppp1cc Ppp2r5e Tuba1a Kpnb1 Tuba1c Tubal3 Rcc1 Tuba4a Chmp2b Cc2d1b Spast Tubb2b Tubb2a Ist1 Hdac8 Chmp3 Vrk1 Chmp7 Chmp6 Lmna Vps4a Sirt2 Tuba8 Chmp4c Tuba3b Chmp4bl1 Tubb6 Tubb3 Tubb1 Banf1 Ran Ankle2 Tubb4b Tubb4a Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Chmp2a Psmb6 Ppp2r2a Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 Lbr Ppp2cb Ppp2ca Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ube2i Espl1 Smc3 Sumo1 Stag2 Stag1 Smc1a Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Sec13 Kif2a Kif2b Kif2c Nup188 Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 96%10222771 AMPK inhibits chREBP transcriptional activation activity Adipoq Adipor2 Adipor1 Prkag2 Prkaa2 Prkab2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-RNO-2299718.1 Condensation of Prophase Chromosomes Ccnb1 Hist1h2ai Phf8 H2ac18 Hist1h2bq Rb1 H2aj Set Plk1 H2ab2 Ncaph2 Hist3h2ba Ncapd3 Kmt5a H2ac4 Smc4 Ncapg2 Cdk1 ENSRNOG00000068602 Smc2 Mcph1 ENSRNOG00000066901 H2az2 H2bc4 Hist1h4m H2bc1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Cdk11b Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Tubg2 Clasp1 Tubg1 Ywhae Cep63 Nme7 Cep152 Tuba4a Plk1 Tubgcp2 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Tubgcp6 Cdk1 Tubgcp5 Tubgcp4 Tubgcp3 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Mzt1 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-RNO-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane Ddost Cd274 Pdcd1 Stt3b Magt1 Mib2 Pdcd1lg2 Rpn2 Rpn1 Ostc Ost4 Tmem258b Tusc3 B3gnt3 Dad1 SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors Myo9b Rhoa ACETYLATION%REACTOME DATABASE ID RELEASE 96%10222689 Acetylation Nat1 Nat2 Nat3 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%10222943 Terminal pathway of complement C6 C5 CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism Aldh7a1 Slc44a1 Slc22a4 Slc44a2 Chdh Bhmt Sardh Dmgdh GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER Xab2 Cdk7 Ppie Tcea1 Mnat1 Polk Prpf19 Usp7 Isy1 Rps27a Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ercc6 Polr2i Polr2j Gtf2h2 Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Lig3 Pole3 Pole2 Pole4 Znf830 Rpa1 Rpa2 Aqr Uvssa Ubb Rpa3 Ubc Lig1 Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Xrcc1 Rfc2 Ccnh Pold4 Pold3 Ddb1 Cul4a Cul4b TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME%R-RNO-9860927.1 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Ikbkg Ppp2r2a Ppp2ca Stat1 Nfkb1 Rela Gna11 Anxa2 Itgb1 Itgb3 Gnaq Pde4d Capn2 Vcl Ptpn1 Ppp2r1b Ppp2r1a Ptk2 Capns1 Yap1 Ikbke Nfkbia Chuk Abl1 Ikbkb Itgav MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225057 MET activates PTK2 signaling Hgf Megf11 Lama4 Itga2 Itgb1 Itga3 Met Ptk2 Src PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway Rac3 Prkcg Wnt5a Prkca Dvl1 Wnt11 Dvl2 Dvl3 Fzd3 Wnt1 Rac1 Fzd1 Fzd2 Psma4 Fzd5 Fzd4 Psma3 Fzd6 Fzd8 Psma6 Psma5 Rhoa Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Arrb2 Psma7 Psmc5 Daam1 Psmc2 Psmc1 Psmc4 Psmc3 Fzd7 Wnt5b Ubb Ror1 Ap2m1 Ror2 Ubc Clta Cltb Wnt4 Psmb6l1 Cltc Psmd7 Prickle1 Psmd6 Psmd8 Psmd2 Prkcb Psmd1 Adrm1 Rac2 Pard6a Smurf1 Ap2s1 Pfn1 Ap2a2 Ap2a1 Ap2b1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-RNO-110313.1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Ufd1 Uba52 Usp10 Pole3 Pole2 Ube2l6 Pole4 Rchy1 Rpa1 Rpa2 Polk Trim25 Ubb Rpa3 Ubc Polh Mad2l2 Rev1 Rev3l Poli Pole Rfc5 Pold2 Pold1 Isg15 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Vcp Pclaf Pold3 Usp43 Rps27a Nploc4 Sprtn Uba7 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-RNO-179409.1 APC-Cdc20 mediated degradation of Nek2A Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Ube2s Cdc16 Anapc15 Rps27a Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Ubb Anapc7 Cdc20 Ubc Nek2l1 Ube2e1 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223965 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrna7 Chrna6 Chrna5 Chrnb4 Chrna4 Chrnb3 Chrnb2 Chrna9 Chrna3 Chrna2 Chrna1 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport Phb1 Pheta2 Micu2 Micu3 Slc8b1 Pmpcb Micu1 Pmpca Maip1 Afg3l2 Mcub Yme1l1 Mcu Parl Stoml2 Spg7 Phb2 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 96%10224921 Transcriptional activation of cell cycle inhibitor p21 Zfp385a Tp53 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223961 Presynaptic nicotinic acetylcholine receptors Chrna6 Chrna5 Chrnb4 Chrna4 Chrnb3 Chrnb2 Chrnd Chrne Chrna3 Chrna2 Chrng Chrna1 SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions Sdk1 Sdk2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking Nos3 Dnm2 Cav1 Nostrin NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling Ppp2cb Ppp2ca Uba52 Frs2 Fgf2 Fgf1 Fgf4 Fgf5 Ubb Fgf8 Fgfr3 Ubc Fgf9 Fgf16 Fgf17 Fgf18 Braf Ppp2r1a Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Fgf23 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9937383.1 Mitochondrial ribosome-associated quality control Mief1 Mrps9 Mrps2 Mrps7 Mrps5 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Ndufab1 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%10224231 Acyl chain remodelling of PC Plb1 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Lpcat4 Pla2g10 Plaat3 Pla2g5 Lpcat1 Pla2g3 Pla2g6 Mboat2 Pla2g4a Pla2g4b Lpcat3 Lpcat2 Tmem86b Pnpla8 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224217 Collagen degradation Mmp8 Furin Mmp10 Col15a1 Ctsb Col13a1 Col19a1 Phykpl Ctsk Try5 Ctsl Col25a1 Mmp7 Mmp2 Mmp3 Prss3 Mmp9 Tmprss6 Mmp1b Col18a1 Ctsd Mmp20 Col26a1 Mmp12 Mmp13 Mmp14 Mmp15 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 96%10224871 Fanconi Anemia Pathway Wdr48 Fancl Fancm Slx4 Fanca Uba52 Eme2 Fancb Fancc Eme1 Fance Fancf Fancg Ercc1 Atrip Ercc4 Ube2t Rpa1 Rpa2 Ubb Rpa3 Ubc Faap100 Slx1b Faap24 Faap20 Atr Rps27a Dclre1a Usp1 Dclre1b Fanci Mus81 Fancd2 Haus3 Fan1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%10223425 Synthesis of Leukotrienes (LT) and Eoxins (EX) Alox5ap Mapkapk2 Abcc1 Alox5 Lta4h Alox15 Cyp4f39 Cyp4f1 Cyp4a14 Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Ggt1 Ggt5 Cyp4f4 Cyp4a10 Cyp4a2 Ltc4s Dpep1 Dpep2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10223587 Serotonin Neurotransmitter Release Cycle Rims1 Tspoap1 Syn3 Syt1 Syn2 Stx1a Ppfia3 Syn1 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Vamp2 Rab3a SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-RNO-9730628.1 Sensory perception of salty taste Scnn1a Scnn1b Scnn1g ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex H2ac18 Hist1h2bq H2aj Psma4 Psma3 H3-3b Ube2s Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 H2bc18 Cdc26 Orc6 Cdc23 Orc1 Orc3 H2az2 Orc2 Cdt1 H2bc4 Psmb5 Gmnn Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Cdc6 Hist1h2ai Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Kpnb1 Ubc Kpna6 Ube2e1 Kpna1 Psmb6l1 Psmd7 Psmd6 Psmd8 H2ab2 Psmd2 Psmd1 Adrm1 H2ac4 Cdc16 ENSRNOG00000066901 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224039 Negative regulation of FGFR1 signaling Ppp2cb Ppp2ca Uba52 Frs2 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Ubc Fgf9 Fgfr1 Fgf17 Braf Ppp2r1a Fgf10 Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Kl Fgf23 Fgf22 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224481 Beta-catenin independent WNT signaling Ctnnb1 Prkcg Wnt5a Gnat2 Prkca Calm3 Gng3 Gng5 Gng4 Dvl1 Dvl2 Wnt11 Gng7 Gnao1 Dvl3 Nlk Gng8 Gngt1 Fzd3 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd8 Gnb2 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Kras Smurf2 Camk2a Lef1 Map3k7 Arrb2 Daam1 Fzd7 Ppp3ca Ppp3cb Wnt5b Nfatc1 Ror1 Ror2 Ppp3r1 Wnt4 Prickle1 Prkcb Pard6a Rac2 Ap2s1 Pfn1 Ap2a2 Ap2a1 Ap2b1 Rac3 Rac1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Pde6g Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Pde6a Pde6b Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Ap2m1 Clta Psmb6l1 Cltb Cltc Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Smurf1 Gng10-ps1 LDL REMODELING%REACTOME DATABASE ID RELEASE 96%10225367 LDL remodeling P4hb Mttp MITOCHONDRIAL UNCOUPLING%REACTOME%R-RNO-166187.1 Mitochondrial Uncoupling Slc25a14 Ucp1 Ucp2 Ucp3 Slc25a4 Pm20d1 Slc25a27 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223111 FGFR3 ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Galnt3 Fgf9 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 96%10224613 SUMOylation of immune response proteins Ikbkg Pias4 Pias3 Ube2i Nfkb2 Sumo2 Ikbke Nfkbia Sumo1 Rela ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223169 Estrogen biosynthesis Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Akr1b10 Cyp19a1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-RNO-69231.1 Cyclin D associated events in G1 Ppp2r2a Ppp2cb Ccnd1 Ppp2ca Uba52 Tfdp2 Tfdp1 Cks1b Cdk7 Cdk6 Rbl2 Rbl1 Mnat1 Ubb E2f1 Ubc E2f2 E2f3 E2f4 E2f5 Cdkn1b Jak2 Rb1 Cdkn1c Ppp2r1b Ppp2r1a Lyn Cul1 Ccnh Cdk2 Src Ccne1 Rps27a Ccne2 Ppp2r3b Cdkn2b Cdkn2d Abl1 Skp2 Cdk4 Skp1 Ccnd2 Ptk6 Ccnd3 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%10222701 Conjugation of benzoate with glycine Glyatl3 Acsm2 Glyat PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Rbbp4 Rbbp7 Mib2 Pdcd1lg2 Prkab2 Prkab1 RT1-Db2 Cd3g Cd247 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da H2ab2 H2ac4 ENSRNOG00000066901 Ccnd1 Kmt2a Kmt2c H2ac18 Csk Csnk2a2 Csnk2a1 Hist1h2bq Wdr5 Ash2l Csnk2b H2aj Ptpn6 Psma4 Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Ptpn11 H2bc18 H2az2 Skp1 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%10222117 Ethanol oxidation Acss1 Aldh1b1 Acss2 Aldh1a1 Adh4 Adh1 Adh7 Adh6 Aldh2 Adh5 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1a2 Man1a1 Man1c1 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-RNO-9769743.1 Amplification and propagation of coagulation cascade F10 F11 Gp5 Gp9 Gp1bb Gp1ba Ano6 Proc Pros1 Serpinc1 Serpine2 F9 Serpina5 F2 F8 Serpind1 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%10224259 Synthesis of PG Cds2 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%10224175 HCN channels Hcn3 Hcn4 Hcn1 Hcn2 METABOLISM%REACTOME%R-RNO-1430728.1 Metabolism Cacna1c Cacna1d Adipoq Adipor2 Adipor1 Mlxipl Marcks Pi4kb Pik3c2g Tpte2 Suclg1 Suclg2 Isca2 Pm20d1 Isca1 Trap1 Sdhaf1 Sdhaf2 Sdhaf3 Cs Slc25a27 Nnt Slc25a14 Ucp1 Ucp2 Ucp3 Fh Sdhd Sdhc Sdhb Sdha Aco2 Idh3B Idh3g Sucla2 Idh3a Cd36 Man2b1 Ormdl3 Alad Agpat2 Cpne1 Cpne3 Manba Them4 Degs1 Cyp24a1 Cyp27b1 Chp1 B3galt6 Cemip Fam20b B4galt7 Pxylp1 Chp1l1 Hyal2 Has1 Has2 Has3 Xylt1 Hs3st4 Xylt2 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Plekha6 Ndst4 Hs3st3a1 Plekha5 Hs6st3 Plekha4 Hs6st2 Plekha3 Hs6st1 Plekha2 Plekha1 Ext2 Tnfaip8l2 Ext1 Fdps Tnfaip8l3 Plpp6 Tnfaip8l1 Rufy1 Idi1 Hsd17b7 Pitpnb Inpp5k Mvk Pik3c2b Fdft1 Sqle Bmx Ebp Tnfaip8 Mtmr7 Hmgcs1 Mtmr6 Arv1 Mtmr9 Ggps1 Sc5d Uros Lbr Alas1 Acat2 Alas2 Hmbs Nsdhl Dhcr24 Cpox Dhcr7 Fech Ppox Lss Cox10 Tm7sf2 Cox15 Srebf2 Pmvk Urod Hmgcr Mvd Msmo1 Srebf1 Pcyt2 Cept1 Etnk2 Etnk1 Etnppl Chka Chkb Selenoi Phospho1 Chat B3galt1 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 Abo2 Cyp21 Cyp11b3 Maob Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Dcxr Cryl1 Xylb Cyp2w1 Cyp2c24 Aldh2 Aldh1b1 Adh6 Adh5 Cmbl Ephx1 Acy3 Aldh3a1 Aadac Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Akr7a3 Akr7a2 Cyp11b1 Cyp11b2 Cyp19a1 Abhd10 Acss1 Mtarc2 Bphl Ubiad1 Vkorc1 Ttpa Vkorc1l1 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pcyt1b Pcyt1a Abhd3 Glul Pemt Chpt1 Stard10 Gpd1l Gnpda1 Abhd4 Osbpl10 Gpi Gnpda2 Miga2 Eno3 Miga1 Gpd1 Eno2 Eno4 Pgp Pfkfb4 Mboat1 Pfkfb3 Mboat2 Pfkfb2 Osbpl5 Pfkfb1 Pld6 Pla1a Pc Pgam2 Osbpl8 Pgam1 Cpne6 Cpne7 Slc37a4 Tpi1 Liph Lipi Slc37a2 Cds2 Slc37a1 Hkdc1 Acp6 Gpat4 Fbp1 Gpat3 Fbp2 Gckr Lpcat3 Lpcat2 Pklr Tmem86b Gapdhs Aldoc Pnpla8 Plaat1 Bpgm Plaat5 Aldoa Agk Pfkl Ddhd2 Pgk2 Agpat4 Pck1 Pfkm Agpat1 Pfkp Pck2 Pgm2l1 G6pc1 Pkml1 Gck Hk2 Hk3 Gc Adpgk A4galt G6pc3 Tpi1l2 Cerk B3galnt1 Ugcg B4galnt1 Ugt8 Sirt3 Gal3st1 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Pld1 Man2c1 Stard4 Star Stard6 Cyp11a1 Tspo Psma4 Fdx2 Fdxr Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Glrx5 Plcb4 Plcb3 Pla2g4a Plcb2 Plcb1 Nudt9 Nudt16 Gda Gng10-ps1 Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 Itpa Dnph1 Adcy5 Nudt5 Adcy6 Dsel Ust Dse Cspg5 Bgn Prkaca Prkacb Cspg4 Chst14 Chst15 Idua Hyal4 Gnai2 Hyal3 Gnai1 Prkca Ids Hyal1 Gna11 Gusb Prkar1a Gna14 Prkar1b Calm3 Gng3 Pomc Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Prkar2a Prkar2b Gnb2 Gnb1 Gnb4 Gnb3 Odc1 Gnb5 Oaz1 Gng11 Oaz3 Oaz2 Nqo1 Azin1 Slc6a7 Slc6a11 Slc25a18 Slc25a22 Adra2a Ca1 Ca2 Ca4 Adra2c Rnf113a1 Crebbp Gale Galt Sin3a Sin3b Galm Csnk2a2 Galk1 Ctsl Csnk2a1 Mfsd2b Sptssa Csnk2b Cers6 Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Ormdl2 Smarcd3 Cidea Cidec Ca12 Ca14 Ca13 Ca3 Ca6 Ca9 Ca5b Ca5a Hsd17b13 Fitm2 Fitm1 St8sia5 Car7 Neu2 Neu3 Neu4 Neu1 St6galnac5 St6galnac6 Slc17a5 St3gal6 St3gal4 St3gal5 St3gal2 St3gal3 St3gal1 Glb1 Ctsa Adhfe1 L2hgdh D2hgdh Prkaa2 Prkag2 B3gnt3 Prkab2 Echs1 Hadh Ecsit Cbr1 Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Mapkapk2 Nosip Akt1 Sbf1 Itpk1 Rab5a Rab4a Plcg2 Mgll Pik3r6 Rab14 Gamt Ckmt1 Ckmt2 Gatm Slc6a8 Ckm Slc6a12 Ckb Dguok Gmpr2 Pnp Ampd3 Ampd2 Itpr3 Ampd1 Adk Itpr2 Itpr1 Gmpr Hprt1 Dck Aprt Ada Slc3a2 Lhb Cga Slc7a5 Ces1d Hadha Hadhb Acadl Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Gstm4 Ltc4s Inpp5d Pik3ca Pik3r1 Pik3cb Pik3r2 Pik3r3 Inppl1 Pik3cd Pik3r5 Pik3cg Alox12 Cyp3a9 Alox5ap Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Pnpla2 Cyp3a2 Mbtps1 Ptgs2 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 Sult1e1 Tpst1 Nup133 Nup210 Tpst2 Sult2b1 Nup155 Sult1a1 Nup153 Sult1c2 Sult1b1 Bpnt2 Akr1c18 Sult6b1 Akr1c12l1 Sult4a1 Akr1c19 Sult2a2 Bpnt1 Ugt1a2 Ugt1a3 Sult2a1 Ugt1a5 Sult2a6 Abhd14b Akr1c21 Podxl2 Ugt2b1 Naglu Hpse2 Hsd11b1 Hsd11b2 Hpse Ugt2b7 Sgsh AC114845.1 Smox Ugt2b34l1 Sat1 Ugt2b Serpina6 Shmt2 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Ugt2b17 Ugt2b37 Ugt2b15 Akr1c9 Cacnb3 Cacna1e Cacnb2 Cacna1a Mtmr1 Cacna2d2 Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Ndufs3 Ocrl Pld2 Ndufa5 Ptpn13 Nampt Shmt1 Ldlrap1 Pdxk Naxe Slc52a2 Slc52a3 Lrpl1 Mccc1 Btd Mccc2 Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Gcgr Bst1 Vnn1 Cblif Tcn2 Fpgs Mmut Mthfs Cubn Mthfr Slc25a32 Slc46a1 Slc23a1 Mthfd1l Slc23a2 Naprt Mmadhc Pcca Rfk Pccb Acp5 Aox1 Slc2a1 Slc2a3 Nadk2 Nudt12 Gcg Mthfd2l Amn Nmrk1 Mocs3 Slc25a16 Hlcs Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Flad1 Mmab Rnls Enpp1 Mocs1 Mmachc Slc22a13 Nfs1 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Mthfd2 Folr2 Gphn Pank4 Mocos Ffar1 Gnas Psap Glp1r Vdr Ppara Tshb Scly Mat1a Grhpr Aldh4a1 Got2 Amt Gnmt Agxt2 Prodh2 Mpst Usf1 Sqor Ethe1 Fmo1 Mri1 Suox Ado Txn2 Bhmt Mtap Enoph1 Tst Adi1 Bhmt2 Gadl1 Cdo1 Slc25a10 Pip4k2b Pip4k2c Pip4k2a Pip5k1a Got1 Mdh1 Mdh2 Slc25a11 Slc25a12 Slc25a13 Chst11 Chst12 Chsy1 Chsy3 Chst13 As3mt Chpf Ahcy Csgalnact2 Comt Chst7 Mtrr Chst9 Gsto1 Tpmt Mat2a Mat2b Mtr Ranbp9 B3gnt5 Prkg2 Lypla1 Rap1a Slc26a2 Slc26a1 Slc35b3 Slc35b2 Papss2 Papss1 Slc26a11 Ran Gpx2 Aloxe3 Gpx1 Alox12b Cyp2s1 Miox Ip6k3 Isyna1 Itpka Itpkc Itpkb Impa2 Impa1 Inpp5a Inpp5b Plch1 Pld4 Plcd1 Plcd4 Inpp5j Plcd3 Nudt4 Nudt3 Synj1 Tkfc Plcz1 Aldh1a1 Plce1 Glyctk Inpp1 Sord Ppip5k1 Aldob Ppip5k2 Akr1b1 Khk Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Rrm2b Atp5pf Txnrd1 Atp5mf Dtymk Atp5me Nudt13 Dmac2l Dut Atp5mg Rrm1 Atp5f1b Tyms Atp5f1a Rrm2 Atp5po Ak1 Atp5mk Gsr Mt-atp8 Nme3 Ak2 Nme2 Ak5 Glrx Ak4 Ak7 Ak6 Ak9 Nme1 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 Acoxl Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Slc35d1 Slc22a5 Slc22a4 Pgk1 Sephs2 Gstz1 Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Chac1 Chac2 Gstm7 Gstm5 Gstk1 Ggct Gstm1 Gclc Gstm2 Mgst3 Gsto2 Esd Cndp2 Mgst2 Mgst1 Gclm Ggt1 Ggt5 Ggt7 Slc9a1 Ggt6 Hpgds Gss Gstp1 Gstt2 Akr1a1 Gstt1 Oplah Slc2a2 Slc36a4 Pias4 Ube2i Slc25a4 Mecr Mtmr14 Mtmr3 Pgam5 Lgmn Sumo3 Prodh Aanat Tph2 Duox1 Tph1 Ddc Pnmt Duoxa1 Duoxa2 Cav1 Asmt Txndc11 Dio1 Dio2 Dio3 Dbh Duox2 Tpo Th Iyd Slc5a5 Gls Dmgdh Tdo2 Tyrp1 Ido2 Hpd Ido1 Slc45a2 Pycr3 Pycr2 Pycr1 Glud1 Aldh6a1 Kyat1 Dhtkd1 Asl Tyr Hal Hykk Pah Acadsb Gpt Phgdh Auh Aadat Agmat Slc25a21 Gcdh Folh1 Arg2 Arg1 Slc25a15 Ivd Aass Oca2 Oat Hdc Bbox1 Aoc1 Fah Asrgl1 Slc25a2 Amdhd1 Aldh9a1 Hsd17b10 Acat1 Serinc4 Serinc5 Serinc2 Aldh18a1 Hgd Serinc1 Haao Gpt2 Kmo Acad8 Carns1 Sirt5 Naalad2 Cps1 Qdpr Hibadh Azin2 Psph Rimkla Rimklb Tat Amd1 Asns Aldh7a1 Nat8l Bcat1 Bcat2 Hibch Pcbd1 Carnmt1 Bckdhb Dct Bckdha Crym Gls2 Psat1 Srm Il4i1 Srr Aspg Nags Aspa Bckdk Tmlhe Uroc1 Chdh Ftcd Kynu Sardh Ppm1k Abcc5 Tymp Upb1 Upp1 Nt5c3a Upp2 Pip5k1b Dpys Dpyd Nt5m Ugt1a6 Ugt1a7 Ugt1a8 Nat1 Dnm2 Nat2 Nat3 Ugt2a1 Ugt2a3 Gmps Ces2h Pon3 Impdh2 Pon1 Acy1a Impdh1 Ugt3a1 Txn Hsp90ab1 Cycsl2 Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Idh2 Gns B4galt4 B4galt5 B4galt6 Acss2 Prelp Glb1l3 Cycs Glb1l2 Fmod Galns Hexa Hexb B4gat1 Lum Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Ogn Plcg1 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Mt-cyb Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 Pdhx Hsp90aa1 Cyp26b1 Pdk4 Pdk3 Pdk2 Pdk1 Pdhb Rxra Cyp26a1 Sphk1 Rdh11 Tbl1x Adh4 Pdha1 Adh1 Pdha2 Hdac3 Tbl1xr1 Zdhhc21 Ppard Ptges3 Mt-co3 Dld Mt-co2 Ncor2 Carm1 Nos3 Fabp5 Cyp26c1 Mt-co1 Mt-nd5 Dlat Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 Tafazzin Lclat1 Higd1c Arf3 Arf1 Cox7a1 Cox7a2 Cox7a2l AC132020.1 Ogdh Dlst Kgd4 Gch1 Idh1 Pdss2 Coq8a Pdss1 Coq8b Coq2 Pts Coq3 Gchfr Coq4 Coq5 Coq6 Hpdl Coq7 Spr Coq9 Stard7 Aco1 Morc2 Hyal5 Ndufa4 Cox6a1 Cox6a2 Cox6c2 Cox6b1 Cox6b2 G6pdx Entpd1 Pip4p1 Entpd2 Entpd5 Entpd6 Entpd3 Cox8a Entpd4 Entpd7 Cox8c Entpd8 Cox7b Cox7c Slco1a4 Slco1b2 Slco2b1 Cox5a Cox5b Phyh Amacr Eci2 Hmox1 Hacl1 Mlycd Scp2 Gnpat Crat Acox1 Acox2 Ehhadh Acox3 Pipox Acaa1b Hsd17b4 Cox4i1 Cox4i2 Hao1 Hao2 Pecr Dao Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Nudt19 Acot1 Acot2 Cygb Acot5 Acot3 Acot4 Cyb5a Acot8 Fxn Abcd1 Baat Ddo Agps Agxt Hmgcl Hscb Ndufb8 Ldhal6b Glo1 Wdr26 Hagh Nek1 Otc Mkln1 Fahd1 Kpnb1 Gid4 Maea Ldha Ldhb Ldhc Armc8 Me1 Me3 Me2 Rmnd5b Ddah1 Nostrin Cyb5b Cox18 Tmem177 Cox20 Ch25h Uxs1 Osbpl3 Ugp2 Osbpl2 Osbpl1a Ugdh Osbpl7 Osbpl6 Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Cyp8b1 Cyp7b1 Slc10a1 Alpi Fabp6 Nr1h4 Abcc3 Stard5 Cyp46a1 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Slc51b Abcb11 Synj2 Ippk Ipmk Ip6k1 Ip6k2 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 Fig4 Agpat3 Vac14 Mtmr12 Pi4k2a Mtmr4 Pik3r4 Gcsh Ndufab1 Fdx1 Dbt Awat2 Awat1 Dhrs7b Far2 Far1 Pla2g6 Bcan Vcan Agrn Ncan Dcn Cyp2j16 Adh7 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Cyp2a2 Cpt1a Cyp2a1 Mid1ip1 Thrsp Cyp4f4 Cpt2 Cyp4a10 Cpt1b Cyp4a2 Cyp2a3 Slc25a20 Kcnb1 Kcns3 Kcnc2 Kcng2 M6pr Sacm1l Pi4ka Ppa1 Ppa2 Lhpp Abcc8 Kcnj11 Rida Sds Sdsl Arsa Smpd2 Cyp1b1 Smpd3 Smpd4 Smpd1 Gba1 Gba3 Cyp4v2 Gba2 Enpp7 Galc Asah2 Asah1 Sts Gm2a Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 Hspa9 Pip5k1c Med1 Plekha8 Pank3 Pank2 Pank1 Ppcs Dcakd Ppcdc Coasy Pdp1 Pdpr Pdp2 Fabp1 Blvrb Hmox2 Blvra Abcg2 Abcc1 Abcc2 Ugt1a1 Hsd3b Hsd17b3 Cyp17a1 Atic Adsl Hsd3b6 Hsd3b5 Ppat Adss2 Srd5a3 Pfas Hsd3b1 Paics Srd5a1 Gart Hsd17b12 Adss1 Srd5a2 Hsd3b5-ps1 Lpin3 Lpin2 Arnt2 Arnt Ahrr Ahr Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Gpc6 Clps Pnlip Akr1b10 Rbp4 Apom Dgat2l6 Rbp2 Rbp1 Dgat2 Dgat1 Sdc1 Lrat Pnpla3 Minpp1 Cbs Cth Rapgef4 Rapgef3 Xdh Phykpl Cd44 Cyp2u1 Hacd1 Hacd2 Hacd3 Hacd4 Hsd17b8 Dpep1 Dpep2 Mcat Acad11 Elovl2 Acly Elovl3 Acaa2 Elovl5 Elovl1 Elovl6 Elovl7 Tecrl Faah Acbd6 Acbd4 Ppt2 Ppt1 Acsf3 Acsf2 Dbi Acot11 Scd1 Acot12 Acot13 Them5 Acot9 Acot7 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 Fads2 Pon2 Fads1 Acadvl Alox15b Cbr4 Tecr Acsbg1 Pctp Acads Acsbg2 Scap Fabp2 Fabp3 Fabp4 Gk Fabp7 Mogat1 Pnpla5 Gpat2 Pnpla4 Mogat2 Vdac1 FABP12 Gpam Gpd2 Agmo Fabp9 Gykl1 Rpe Taldo1 Prps1l3 Pgd Prps1 Rpia Dera Prps2 Shpk Pgm2 Pgls Tkt Rbks Cda Umps Cad Samhd1 Pudp Dhodh Tk2 Uck1 Uck2 Oxct2a Acss3 Bdh2 Bdh1 Oxct1 Hmgcll1 Hmgcs2 Aacs Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Uqcrfs1 Nubpl Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Cyc1 Ndufv2 Ndufv1 Ndufv3 Uqcrb LOC120097699 Uqcrh Ndufc2 Ndufa12 Ndufa11 Pten Ndufa10 Ndufs1 Timmdc1 Ndufa13 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Eci1 Ndufs6 Acadm Ndufs8 Decr1 Acer1 Ndufa6 Acer2 Ndufa9 Aldh3b1 Ndufa8 Ndufb11 Sgpl1 Ndufb10 Aldh3b2 Acer3 Ndufb1 Lyrm7 Sgpp2 Ndufb3 Plpp2 Plpp3 Hccs Uqcrc2 Plpp1 Uqcrc1 Sgpp1 Etfb Lyrm4 Ndufb5 Etfa Lyrm2 Ndufb7 Dmac2 Maoa Dmac1 Tspoap1 Ndufa3-ps3 Uqcr10 Ttc19 Inpp5e Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Phkg1 Gaa Gbe1 Phkg2 Agl Pygl Pygm Phkb Ppp1r3c Gys1 Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Ptdss1 Ptdss2 Pla2g15 Pla2g4b Gde1 Pnpla6 Enpp6 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME%R-RNO-9943962.1 CHD6, CHD7, CHD8, CHD9 subfamily Hist1h2ai H2aj Fam124b H2ab2 Ctnnb1 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Ctcf H2bc18 Chd6 Chd7 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Chd8 Hist1h4m H2bc1 Wdr5 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Pros1 F10 F7 F9 Bglap Gas6 F2 Proc Proz CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-RNO-1834949.1 Cytosolic sensors of pathogen-associated DNA Stat6 Ikbkg Mre11 Uba52 Aim2 Nfkb2 Nfkb1 Crebbp Ctnnb1 Trim32 Rela Nlrp4 Dtx4 Dhx9 Myd88 Ubb Ubc Dhx36 Nfkbib Tbk1 Irf3 Nfkbia Ddx41 Ep300 Rps27a Sting1 Nkiras1 Chuk Ikbkb Irf7 Nkiras2 Trim21 APAP ADME%REACTOME%R-RNO-9753281.1 APAP ADME Sult1a1 Abcg2 Abcc1 Sult2a2 Abcc2 Ugt1a1 Sult2a1 Abcc3 Sult2a6 Cyp2e1 Ugt1a6 Ugt1a7 Cndp2 Ugt1a8 Nat1 Nat2 Ggt1 Nat3 Ggt5 Ggt7 Ggt6 Gstp1 Acy1a Ugt2b15 Gstt1 Abcc4 Abcc5 Sult1e1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224211 Downregulation of ERBB2:ERBB3 signaling Rps27a Rnf41 Erbb2 Erbb3 Uba52 Nrg2 Akt3 Ubb Akt2 Akt1 Ubc Usp8 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN Irf3 TRNA PROCESSING%REACTOME%R-RNO-72306.1 tRNA processing Yrdc Qng1 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%10223855 Miscellaneous transport and binding events Azgp1 Lrrc8e Dmtn Lrrc8a Lrrc8b Nipa1 Lrrc8c Magt1 Nipa2 Lrrc8d Rhag Rhcg Rhbg Slc66a1 Pip Add1 Add3 Tusc3 Ctns Nipal4 Nipal2 Add2 Ankh Mrs2 Nipal3 Nipal1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222299 Triglyceride biosynthesis Agmo Dgat2 Gykl1 Dgat1 Gk Lpin3 Mogat1 Lpin2 Gpat2 Mogat2 Gpam RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%10224805 RHO GTPases Activate Rhotekin and Rhophilins Rtkn Rhpn1 Rhpn2 Lin7b Rhoa IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%10224051 IRAK1 recruits IKK complex Peli1 Peli2 Ikbkg Peli3 Ube2n Chuk Ikbkb Irak1 Traf6 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223387 Thyroxine biosynthesis Duox1 Duoxa1 Duoxa2 Cav1 Txndc11 Dio1 Dio2 Dio3 Cga Duox2 Tpo Iyd Slc5a5 Tshb SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-RNO-446199.1 Synthesis of dolichyl-phosphate Dhdds Srd5a3 Mvd Dolpp1 Dolk Dhrsx Nus1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%10222767 Class B 2 (Secretin family receptors) Pthlh Iapp Adm Gng3 Ramp1 Gng5 Vip Gng4 Gng7 Calcr Gng8 Gngt1 Ucn2 Ucn3 Gnb2 Gnb1 Crhr2 Gnb4 Crhr1 Gnb3 Calcb Gnb5 Gng11 Calca Gipr Gnas Calcrl Pth1r Sct Pth Ucn Gcgr Sctr Adcyap1 Crhbp Ghrh Pth2r Gcg Gip Ghrhr Ramp3 Glp1r Ramp2 Crh Gng10-ps1 Adgre5 Adgre1 Vipr2 Adm2 Pth2 Vipr1 Glp2r Cd55 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222501 PKA activation Adcy5 Adcy6 Adcy9 Prkar2a Prkar2b Prkaca Prkacb Prkar1a Prkar1b Calm3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Gsk3b Ppp2r1b Apc Ppp2r1a Ctnnb1 Frat2 Frat1 Csnk1a1 Ppp2r5e Amer1 Ppp2r5d Axin1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%10222837 Toll Like Receptor 10 (TLR10) Cascade Ppp2cb Ppp2ca Tlr10 Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion Adarb1 Adar INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation Ffar4 Dpp4 Gpr119 Lep Gcg Ffar1 Gip Grp MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223605 Mitochondrial ABC transporters Abcb6 Abcb7 Abcb8 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-RNO-157858.1 Gap junction trafficking and regulation Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Tjp1 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Dnm2 Ap2m1 Gja1 Clta Cltb Myo6 Cltc Dab2 Dnm1 Src FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%10222535 Formation of apoptosome Mapk1 Apip Cycsl2 Diablol1 Casp9 Apaf1 Cycs Xiap Mapk3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%10223597 Transcriptional regulation of white adipocyte differentiation Pparg Ncor2 Hdac3 Rxra TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-RNO-171319.1 Telomere Extension By Telomerase Acd Terf1 Shq1 Dkc1 Nhp2 Pif1 Terf2ip Gar1 Wrap53 Tinf2 Rtel1 Pot1 Nop10 Ccna1 Ccna2 Cdk2 Ppp6r3 Ankrd28 Ppp6c Tert Terf2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%10223313 Apoptotic cleavage of cellular proteins Ocln Casp7 Apc Mapt Tjp1 Ctnnb1 Prkcq Prkcd Birc2 Dsg3 Cdh1 Plec Dsp Casp3 Bcap31 Dsg1 Gsn Dsg2 Casp6 Satb1 Gas2 Sh3glb2 Add1 Rock1 Clspn Tjp2 Casp8 Ptk2 Stk26 Sptan1 Stk24 Pkp1 Lmna Bmx Lmnb1 Fnta Acin1 Vim ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%10223959 Acetylcholine binding and downstream events Chrnb4 Chrnb3 Chrnb2 Chrnd Chrne Chrna3 Chrng Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrna4 Chrna9 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223097 FGFR1b ligand binding and activation Tgfbr3 Gipc1 Fgf2 Fgf1 Fgf3 Fgf10 Fgf22 Fgfr1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-RNO-2559582.1 Senescence-Associated Secretory Phenotype (SASP) Ehmt1 Cdk6 H2ac18 Hist1h2bq H2aj Ccna1 H3-3b Ccna2 Mapk3 Ube2s Hist3h2ba ENSRNOG00000068602 Rps27a Ube2c Cdkn2b Cdkn2d Cdc27 H2bc18 Cdc26 Cdc23 H2az2 Mapk7 H2bc4 Hist1h4m H2bc1 Hist1h2ai Uba52 Anapc10 Ube2d1 Anapc16 Anapc15 Rps6ka3 Rps6ka1 Rps6ka2 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Cebpb Ube2e1 Cdkn1b H2ab2 Cdk2 H2ac4 Cdc16 Mapk1 ENSRNOG00000066901 Cdk4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization Mapk1 Golga2 Plk1 Gorasp1 Rab2a Blzf1 Rab1A Rab1b Mapk3 Gorasp2 RHOBTB1 GTPASE CYCLE%REACTOME%R-RNO-9013422.1 RHOBTB1 GTPase cycle Cpsf7 Myo6 Txnl1 Pde5a Stk38 Rbbp6 Cct7 Rnf20 Cops4 Cops2 Spen Gps1 Hnrnpc Rbmx Tra2b Cct2 Cul3 Vim Rhobtb1 Rock2 Rock1 Srrm1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors Ptgdr2 Ptger2 Ptger3 Ptger1 Cysltr2 Cysltr1 Ltb4r Gpr17 Ptgdrl Tbxa2r Ptgir Ltb4r2 Ptgdr Ptger4 Ptgfr REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%10224607 Regulation of FZD by ubiquitination Uba52 Fzd5 Lgr5 Fzd4 Lgr6 Fzd6 Fzd8 Rps27a Znrf3 Rspo1 Rspo3 Rspo2 Rspo4 Ubb Ubc Rnf43 Lrp6 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 96%10225417 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Uba52 Tbk1 Ikbke Optn Rps27a Traf3 Tank Ly96 Ticam2 Ubb Ubc Ticam1 Cd14 Tlr4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) LOC120093247 Ppp2ca Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Magohb Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Ppp2r1a Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Ncbp2 Ncbp1 Rpl23a Upf3b Upf3a Eif4a3 Smg1 Smg9 Smg8 Smg7 Smg6 Smg5 Upf1 Upf2 Rbm8a Casc3 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Pabpc1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Ppp2r2a Rps4x-ps13 Rpl38 Rps3a Etf1 Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Pnrc2 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rnps1 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Magoh Rpl12-ps1 Ubc Rps20 Rps21 Dcp1a Rpl22 Rps23 Rps24 Rpl23 Gspt2 Gspt1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 INTERLEUKIN-12 SIGNALING%REACTOME%R-RNO-9020591.1 Interleukin-12 signaling Vamp7 Il12a P4hb Jak2 Tyk2 Il12rb1 Il12rb2 Il12b REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%10224549 Regulation by c-FLIP Ripk1 Tnfsf10 Casp8 Fas Fadd Faslg Traf2 Tradd Cflar REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%10224149 Reversible hydration of carbon dioxide Ca5a Car7 Ca12 Ca1 Ca14 Ca2 Ca13 Ca3 Ca4 Ca6 Ca9 Ca5b TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 96%10223913 TRAF6-mediated induction of TAK1 complex within TLR4 complex Map3k7 Uba52 Irak2 Rps27a Tab3 Tab2 Tab1 Ly96 Ticam2 Ubb Sarm1 Ubc Ticam1 Cd14 Traf6 Tlr4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 96%10222061 Neuronal System Gls2 Cacnb3 Cacnb4 Creb1 Cacnb1 Cacna1e Cacnb2 Stx1a Cacna1a Cacna1b Cacna2d3 Cacng4 Flot2 Cacna2d2 Cacng2 Flot1 Ntrk3 Vamp2 Lin7b Rps6ka3 Rps6ka1 Rps6ka2 Panx1 Slitrk5 Slitrk3 Cacng8 Cacng3 Chrnb4 Chrnb3 Chrnb2 Grip2 Prkcb Epb41l1 Gabrg2 Gabrg3 Grin3a Chrna3 Chrna2 Ap2s1 Chrna1 Chrna7 Grik5 Chrna6 Chrna5 Chrna4 Grik4 Ap2a2 Ap2a1 Chrna9 Grik3 Ap2b1 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabra2 Gabra1 Akap5 Glra3 Gja10 Glra2 Gjc1 Glra1 Gjd2 Rps6ka6 Tspan7 Camk1 Shank1 Glrb Shank3 Ncald Homer1 Grip1 Homer2 Chrnd Gabrr1 Nrxn1 Chrne Nrxn2 Gabrr3 Nrxn3 Gabrr2 Epb41 Chrng Epb41l2 Gabrq Epb41l3 Gabrb1 Epb41l5 Gabrb3 Lrrtm1 Slc18a3 Gabrb2 Lrrtm2 Lrrtm3 Htr3b Lrrtm4 Htr3a Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Nlgn3 Lrrc4b Il1rapl1 Ptprf Il1rapl2 Gabbr1 Slitrk6 Slitrk4 Slitrk1 Slitrk2 Gabbr2 Ppfibp2 Ppfibp1 Dnajc5 Kcnd3 Kcnd2 Kcnd1 Kcnab2 Hspa8 Rab3a Slc5a7 Lrfn2 Rtn3 Lrfn3 Lrfn4 Lrfn1 Ptprs Kcnb2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnf1 Kcnh3 Kcnq5 Gng10-ps1 Adcy3 Kcnk13 Kcnab1 Adcy4 Kcns2 Adcy1 Kcns1 Adcy2 Kcnab3 Kcna7 Camkk1 Kcna6 Adcy7 Kcna4 Camkk2 Kcna3 Adcy8 Kcna10 Kcna2 Adcy5 Kcnb1 Adcy6 Kcns3 Kcnc4 Kcna1 Kcnc2 Tomt Kcnc3 Kcng2 Adcy9 Kcnc1 Kcng4 Kcng3 Kcng1 Prkaca Kcnh1 Prkacb Prkcg Kcnv2 Kcnv1 Gnai2 Gnai1 Prkca Slc1a1 Gnai3 Camk4 Prkar1a Slc38a2 Prkar1b Slc1a7 Calm3 Slc1a6 Nsf Gng3 Gnal Kcna5 Sh3glb2 Gng5 Slc6a12 Gng4 Kcnq1 Il1rap Gng7 Kcnh2 Gng8 Gngt1 Kcnj9 Kcnj8 Gnat3 Prkar2a Kcnj6 Prkar2b Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Kcnj1 Gnb2 Kcnj14 Abcc8 Gnb1 Kcnj11 Gnb4 Kcnj12 Abcc9 Grin2a Gnb3 Lrrc7 Gnb5 Kcnj15 Gng11 Gria4 Kcnj16 Slc22a2 Gria3 Camk2g Camk2d Slc22a1 Gria2 Slc32a1 Camk2b Dlg1 Dlg2 Gria1 Actn2 Slc6a11 Dlg3 Slc6a13 Dlg4 Camk2a Nefl Grin1 Aldh5a1 Grik2 Grin2d Grik1 Grin2c Slc17a7 Naaa Abat Grin2b Slc6a1 Syn3 Slc6a4 Syn2 Slc6a3 Syn1 Cask Chat Panx2 Lin7a Lin7c Gad1 Gad2 Apba1 Arl6ip5 Grm1 Grm5 Rims1 Maoa Tspoap1 Syt1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Kcnn2 Hcn3 Hcn4 Kcnma1 Hcn1 Hcn2 Aldh2 Kcnk4 Kcnk2 Kcnk1 Kcnk10 Kcnk16 Kcnk9 Kcnk7 Kcnk18 Kcnk6 Arhgef9 Gls Slc38a1 Ap2m1 Slc1a3 Slc1a2 Glul Myo6 Comt PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%10221941 Processive synthesis on the lagging strand Fen1 Pold2 Pold1 Pcna Pola2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Rpa3 Lig1 Dna2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222379 RNA Polymerase III Transcription Initiation From Type 3 Promoter Bdp1 Tbp Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Crcp Polr3a Brf2 Polr3d Polr1c Polr3e Polr3b Polr3c Polr2h Polr3f Polr3g Polr2e Pou2f1 Polr2f AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223477 Agmatine biosynthesis Agmat Azin2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB Camk4 Calm3 Camkk1 Camkk2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 96%10224141 Cross-presentation of particulate exogenous antigens (phagosomes) Cyba Ncf4 Cybb Cd36 Itgav Ncf1 Ncf2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts Ncoa2 Baat Slc10a1 Fabp6 Nr1h4 Abcc3 Stard5 Slc27a5 Slc51a Slc51b Abcb11 Alb Slco1a4 Slco1b2 Rxra LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 96%10224883 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Ccnb1 Gadd45a Pcna Sfn Cdk1 Aurka Bax FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 96%10222367 Formation of the Editosome Apobec1 A1cf Apobec4 Apobec2 Apobec3 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%10224903 TP53 Regulates Transcription of Cell Death Genes Igfbp3 Tmem219 Steap3 Cradd Pidd1 Casp2 Rabggta Bnip3l Rabggtb LOC134478826 Atm Chm DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%10224261 Degradation of DVL Psmb6 Dact1 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Hecw1 Klhl12 Ubb Ubc Dvl1 Dvl2 Psmb6l1 Dvl3 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cul3 Psmb5 Psmb4 Psmb7 NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance Slc22a2 Maoa Tomt Slc6a4 Slc22a1 Slc6a3 Comt Aldh2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 96%10222951 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Cdc14a Anapc10 Ube2d1 Anapc16 Ube2s Cdc16 Anapc15 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Fzr1 Anapc7 Cdc20 Ube2e1 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10225019 Lipid particle organization Hsd17b13 Fitm2 Fitm1 Cidea Cidec REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10221989 Regulation of TP53 Activity through Phosphorylation Rhno1 Dyrk2 Rad50 Prkab2 Prkab1 Csnk2a2 Topbp1 Rbbp8 Csnk2a1 Ssrp1 Brca1 Cdk5r1 Rad1 Csnk2b Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Ccna1 Taf12 Cdk5 Tbp Ccna2 Taf4b Taf7l-ps1 Tp53rkb Noc2l Tp53rka Taf8 Rps27a Taf7 Taf6 Taf5 Hipk1 Taf4 Taf2 Taf1 Blm Wrn Plk3 Dna2 Mre11 Uba52 Kat5 Nbn Hus1 Atrip Aurka Aurkb Chek1 Chek2 Rad9a Rpa1 Rad9b Rpa2 Bard1 Tpx2 Top3a Ubb Rpa3 Ubc Tp53 Rad17 Rfc5 Prkaa1 Mapk14 Rfc3 Prkaa2 Rfc4 Rfc2 Cdk2 Atm Atr Nuak1 Exo1 Prkag3 Prkag1 Rmi2 Prkag2 Mdm4 Rmi1 Brip1 Mapk11 Stk11 Mapkapk5 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 96%10224761 Phospholipase C-mediated cascade; FGFR3 Fgf16 Fgf17 Fgf18 Plcg1 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%10222615 Metabolism of serotonin Maoa Aldh2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification Qtgal Adamts1 Adamts3 Adamts2 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Pofut3 Pofut4 Thsd4 Cfp Spon2 Icmt Spon1 Sspo B3glct B3gnt9 B3gnt8 Fn1 B3gnt6 B3gnt5 Galnt1 Galnt2 Rce1 Galnt5 ENSRNOG00000067432 Galnt7 Fut8 Fuca1 Galnt6 Man2a1 Galnt10 Man2a2 Galnt17 Mgat2 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5a Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Tgfa Adamts19 Fgf23 Adamts10 Sbspon Areg Kbtbd7 A4gnt Adamts12 Thsd7a Nop58 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Commd9 Adamts20 Thsd7b Ceacam6 Cgm4 Commd3 Rab44 Rab37 Il6 Psgb1 Rab3d Fga Fgg Fcgr3a Psg29 Tf Cdc25a Hspa8 Rpa1 Mgat5 Mgat1 Slc35c1 Mgat3 Manea Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Rraga Rps6 Mvd Lrr1 Fbxl21 Wsb1 Ccnf Lypd6b Rtn4rl2 Gpld1 Cdc34 Lypd8 Tecta Lypd5 Lypd4 Lypd3 Negr1 Tex101 Lypd2 Lypd1 Alpl Opcml Tectb Dpm1 Dpm3 Otoa Izumo1r Ube2g2 Ly6g6d Ube2g1 Cd52 Prss21 Nrn1 Ntm Gp2 Kbtbd8 Xpnpep2 Fbxw4 Thy1 Fbxw5 Art4 Fbxw7 Art3 Gan Fbxw8 Atrnl1 Fbxw9 Lsamp Reck Sprn Plet1 Fbxw2 Psca Klhl5 Spaca4 Cntn4 Mdga1 Blm Klhl3 Cntn3 Mdga2 Klhl2 Cntn5 Spsb2 Ly6e Ly6h Prnd Spsb1 Ly6d Prss41 Spsb4 Pias4 Ube2i Eloc Elob Kctd7 Kctd6 Ube2w Ube2m Ube2k Ube2v2 Pdia3 Ube2b Bard1 Ube2f Ube2a Fbxo10 Prkdc Fbxo11 Fbxo15 Fbxo17 Clspn Lmo7 Lrrc41 Klhl13 B4galnt2 Klhl11 Ube2z Xrcc4 Fbxo21 Bap1 Fbxo22 Tp53bp1 Fbxo27 Brcc3 Uba6 Fbxw17 Herc2 Rnf168 Sumo1 Klhl25 Ube2e3 ABRAXAS1 Sumo3 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Rad52 Fbxl5 Fbxl7 Zbtb16 Uba1 Babam1 Babam2 Cul2 Cul5 Ubxn1 Cul7 Brca1 Fbxo41 Fbxo44 Uimc1 Riox2 Klhl41 Fbxo40 Btbd1 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Mitf Asb18 Asb17 Ube2r2 Fbxo4 Jmjd6 Fbxo6 Fbxo7 Fbxo9 Vhl Dync1h1 Fbxl15 Fbxl16 Fbxl19 Cdca8 Incenp Dync1i2 Dync1i1 Asb9 Asb7 Dhdds Asb6 Nudt14 Asb5 Alg5 Dolpp1 Asb4 Fuom Gmds Dolk Asb1 Fcsk Dhrsx Nus1 Fpgt Gfus Rangap1 Dync1li2 Dync1li1 Dynll1 Dynll2 Cop1 Mdm4 Birc5 Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Men1 Ube2t Otulin Tnks2 Axin1 Axin2 Dhps Eif5a Fn3k Fn3krp Eif5a2 Dohh Notum Alg9 Alg8 Cdc73 Alg6 Rnf146 Alg3 Alg2 Alg13 Alg14 Ctbp1 Alg12 Tnks Mpdu1 Dpagt1 Usp34 Smurf2 Leo1 Apc Amfr Engase Ngly1 Nlrp3 Rig1 Ikbke Cyld B3gnt7 B3gnt2 B4galt4 B4galt5 B4galt6 B4gat1 B4galt2 B4galt3 Ktn1 Psmg1 Psmg4 Psmg3 Psma4 Psmd10 Ccna1 Pomp Psma3 Psmd5 Psmd4 Ccna2 Ube2s Psma6 Psma5 Nrip1 Psma2 Psma1 Rps27a Psmd12 Dtl Psmd11 Ube2c Psmd14 Psmd13 Mta1 Skp2 Nr1h3 Skp1 Nr1h2 Cdc20 Psmb5 Psmb4 Psmb7 Rxra Psmb6 Dnajc3 Psmb1 Psmb3 Pgr Psmb2 Uba52 Nub1 Neurl2 Ube2d1 Commd8 Fem1b Fem1a Btrc Tulp4 Psma7 Fem1c Dcaf8 Dcaf4 Aurkb Dcaf5 Psmc5 Dcaf6 Psmc2 Dcaf7 Ccdc22 Psmc1 Psmc4 Obsl1 Psmc3 Dda1 Ccdc8 Commd4 Commd5 Commd6 Commd7 Commd2 Spsb3 Ubb Ankrd9 Rara Socs2 Ubc Commd10 Socs6 Ube2e1 Psmb6l1 Ubd Wdtc1 Npm1 Psmd7 Dcun1d5 Dcun1d4 Psmd6 Dcun1d3 Psmd8 Cish Dcun1d2 Psmd2 Dcun1d1 Cul9 Psmd1 Dcaf17 Adrm1 Dcaf10 Cul1 Dcaf11 Cdk1 Epas1 Hif3a Yy1 Dlat Nr5a2 Ins1 Lman1 Scfd1 Actr1a Lman2 Ins2 Ggcx Sec22a Bglap Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Rab2b Arfgap2 Rab34 Cog5 Rab20 Arfgap1 Igfbp3 Cog6 Ptp4a2 Rab23 Cog7 Rab26 Cog8 Rab25 Calm3 Napa Rab29 Nsf Rab40b Napb Rab15 Ank1 Rab17 Napg Rab19 Sec23a Rab3c Tmem115 Rab3b Kdelr2 Mettl22 Kdelr3 Sec23ip Etfbkmt Sec16b Kin Sec16a Mettl21a Eef2kmt Lman2l Copa Eef1akmt2 Bet1l Eef1akmt1 Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Ppp6c Muc15 Sec31b Muc13 Sec31a Muc19 F8 Umod Muc5b Muc4 Asgr2 Stx17 Gosr1 Muc6 Asgr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Dlst Ckap4 Tp53 Skic8 Polb Parp1 H2ac4 Actl6a Gata3 Ring1 ENSRNOG00000066901 Phc2 Phc1 Cbx4 Hsp90b1 Ttll6 Socs5 Ttll7 Cbx2 Ttll4 Esr1 Phc3 Ttll5 Ttll10 Ttll2 Chst10 Ttll3 Fkrp Ttll11 Slc35a4 Rxylt1 Ttll12 Crppa Ttll8 Dag1 Ttll13 H2ac18 Ttll9 Large1 Large2 Sin3a Fktn Pomgnt1 Bmi1 Actg1 Hist1h2bq Hdac1 Wdr5 Ep300 Rnf2 ENSRNOG00000068602 Rabggta Kat2b Rabggtb Rbbp5 H2bc4 Hist1h4m H2bc1 Pml Hist1h2ai St8sia6 Etf1 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 St3gal6 St6galnac2 St3gal4 St3gal5 St3gal2 St3gal3 Slc35a1 St3gal1 Nanp St6gal1 Glb1 St6gal2 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne Rbx1 Socs3 Vcp Hnrnpc Hnrnpk Cops5 Cul3 B3gnt3 Suz12 Rbbp7 Ube2d3 Ube2d2 Spta1 Sptb Sptbn1 Sptbn2 Ide Sptan1 Sptbn5 Sptbn4 Pex2 App Usp9x Nagk Gnpnat1 Traf6 Amdhd2 Pex5 Ikbkg Uap1 Gfpt1 Gfpt2 Map3k7 Pgm3 Ube2n Renbp Nfkb2 Traf2 Fbxw11 Rela Pex14 Tnip2 Pex13 Nod2 Pex12 Nod1 Pex10 Ripk2 Kat2a Hdac2 Hdac4 Nfkbia Usp14 Usp18 Tab1 Cetn2 Furin Alpi Nr1h4 Ltbp1 Bmp4 Fbn1 C4b Rab36 C4 Cops3 Cops6 Cops8 Rab11b Rab11a Rab31 Rab35 Rab38 Rab1b Trappc2l Gcsh Rab5a Lipt1 Rab4a Lipt2 Nfu1 Trappc10 Ndufab1 Fdx1 Rab33b Dbt Rab33a Lias Cops7a Cops7b Rab3a Tnc Dmp1 Chm Rab7a Rab7b Vcan Rab27a Rab39a Rab27b Akp3 Trappc6b Trappc6a Alpp Trappc9 Alpg Trappc5 Trappc4 Trappc3 F7 F9 Trappc2 Trappc1 Gas6 Rab6b Rab6a Ceacam1 Rab5c Ahsg Rab5b Spp2 Galnt3 Rab43 F10 Rab21 Chml Rab9a Rab9b Rab1A Ttgn1 Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Qsox1 Serpina10 Rhoa Dph5 Dph6 Eef2 H2ac25 Gria1 Prmt3 Rps2 Serpind1 Calr Arsa Arrb2 Arrb1 Tgfbr1 Pros1 Sts Serpinc1 Arsl Arsk Cd109 Arsj Arsi Arsg Sumf1 Thbs1 Arsb Sumf2 Cdh2 Pcna Prkcsh Rab4b Cand1 Ctsz Pomt1 Pomt2 Scg3 Psme2 Psme1 Psmb9 Birc2 Proc Psmb10 Psmb8 Proz Aplp2 Mmrn1 Megf11 Canx Chgb Pdia6 Ccn1 Amelx Pigs Lgals1 Pigu Csf1 Pigt Gpaa1 Scg2 Pigk Apoa5 Meltf Plaur Pgap1 Mxra8 Fam20a LOC120093819 Fam20c Fuca2 Stc2 Wfs1 Apol7al1 Hrc Pcsk9 Ambn Mepe Cp Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Hcfc1 Igfbp7 Mfge8 Matn3 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tada3 Tmem132a Afp Pnpla2 Mbtps1 Nup93 Mcrs1 Igfbp5 Nup50 Igfbp4 Golm1 Igfbp1 Amtn Ogt Nup35 Mgat4a Nucb1 Nup54 Nup98 Sparcl1 Msln Cst3 Itih2 Nup58 Apol9a Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Ctr9 Nup160 Paf1 Rae1 Ndc1 Nup85 Nup42 Traf3 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 Tpst1 Nup133 Tpst2 Nup210 Nup155 Nup153 Srd5a3 Pign Pigq Alb Pigp Pigw Pigv Pigx Pigc Mrtfa Pigb Dpm2 Piga Pigm Pigl Pigg Pigf Pigh Gmppa Pmm2 Apoa1 Mpi Prkn Pmm1 Apoa2 Sar1b Ripk1 Gps1 Apoe P4hb Nploc4 Apob Ube2l3 Sdc2 Gpihbp1 Gpc3 Cops4 Cops2 Mgat5b B3galnt2 Pomk Pomgnt2 Rnf20 Adam10 Senp1 C3 Adamts5 Adamts4 Spp1 Uba2 Rwdd2b Sae1 Timp1 Eef1a1 F2 Penk Bst1 Vnn1 Rps23 Stambpl1 Nfrkb Myc Foxk2 Foxk1 Vdac2 Yod1 Vdac3 Vdac1 Tfpt Becn1 Tomm70 Otud7a Actr5 Otud7b Actr8 Josd2 Josd1 Rnf123 Rnf128 Stam Snx3 Ar Hif1a Zranb1 Cftr Cd55 Siah2 Keap1 Ino80 Wdr48 Ddb2 Ufd1 Foxo4 Uchl3 Abraxas2 Uchl5 Folr2 Ifih1 Fkbp8 Ino80e Ino80d Rnf181 Ino80c Shprh Ino80b Rad18 Il33 Wdr20 Rnf152 Rnf40 Mbd5 Mbd6 Adrb2 Rnf144a Hltf Uchl1 Wac Nedd8 Atxn3 Atxn7 Suds3 Usp2 Mul1 Usp3 Usp4 Kdm1b Usp5 Usp7 Usp8 Hgs Ruvbl1 Stambp Rad23a Rad23b Tomm20 Tada2b Senp5 Senp5l1 Smad1 Sumo2 Smad2 Senp2 Smad3 Smad4 Smad7 Otub1 Usp44 Usp42 Usp48 Kng1 Usp47 Stam2 Usp30 Otub2 Vcpip1 Usp33 Usp37 Mysm1 Tnip3 Tnip1 Senp8 Otud3 Usp22 Usp21 Usp20 Usp26 Usp25 Usp24 Usp29 Usp28 Ccp110 Asxl1 Asxl2 Pten Usp12 Usp11 Usp10 Usp16 Usp15 Usp13 Usp19 Etfb Bcl10 Rab2a Nr1i2 Smc6 Smc5 Smc3 Pias3 Ddx17 Sp140 Pias1 Pias2 Nsmce4a Casp8ap2 Hic1 Eid3 Uhrf2 Nr3c2 Nr3c1 Nsmce1 Nsmce2 Xpc Zfp131 Sp3 Vdr Stag2 Stag1 Dnmt1 L3mbtl2 Daxx Safb Mageb10 Sp100 Ing2 Ppara Top2b Top2a Top1 Trim28 Trim27 Pcgf2 Thrb Thra Mbd1 Satb2 Satb1 Park7 Smc1a Nr5a1 Nfe2l2 Taf9b Tfap2c Taf10 Tdg Rpl8 Camkmt Ubxn7 Rpl27a Ddb1 Cul4a Dcaf13 Cul4b Mat2b SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors Sumo3 Pias4 Tfap2c Sp3 Ube2i Sumo2 Tp53bp1 Mitf Pias3 Mta1 Pias1 Pias2 Hic1 Sumo1 INOSITOL TRANSPORTERS%REACTOME%R-RNO-429593.1 Inositol transporters Slc5a11 Slc5a3 Slc2a13 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME%R-RNO-983170.1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC Tapbp RT1-M1-5 Calr Rt1-ec3 Sec24d Sec24c Sec24b Sec24a Erap1 Hspa5 RT1-M6-2 AABR07044308.1 Pdia3 B2m Sec23a Tap2 Tap1 RT1-M10-ps1 RT1-M10-ps5 Canx RT1-N3 Sec13 RT1-M5 Sar1b RT1-M2 Sec31a RT1-M1-2 SIGNALING BY NOTCH3%REACTOME%R-RNO-9012852.1 Signaling by NOTCH3 Aph1b Ybx1 Egfr Jag1 Uba52 Jag2 Notch3 Dll1 Dll4 Rps27a Egf Adam10 Wwp2 Psenen Psen1 Psen2 Ubb Ncstn Ubc Aph1a COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224947 COPI-dependent Golgi-to-ER retrograde traffic Rab1A Arfgap3 Arfgap2 Arfgap1 Racgap1 Bnip1 Napa Nsf Kif18b Napb Kif19 Kif26b Napg Kifc1 Kifc2 Kif3a Kif26a Kdelr2 Kdelr3 Kif11 Kif12 Copa Kif15 Nbas Kif5a Kif5b Kif21a Kif1c Kdelr1 Arf4 Kif21b Arf3 Kif13b Arf1 Kif1a Kif1b Kif6 Copb2 Tmed10 Tmed9 Kif9 Copb1 Zw10 Cope Kif22 Rab1b Kif23 Kif28 Rint1 Kif27 Kif16b Kif18a Kif20a Klc1 Copz2 Kif20b Kifap3 Copz1 Arf5 Klc4 Klc3 Klc2 Kif3b Kif3c Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Arcn1 Stx18 Cenpe Kif2a Use1 Kif2b Kif2c Kif4b Kif4a PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%10225111 Processing of SMDT1 Phb1 Pheta2 Micu2 Micu3 Pmpcb Micu1 Pmpca Maip1 Afg3l2 Mcub Yme1l1 Mcu Parl Stoml2 Spg7 Phb2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 96%10224403 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp1a1 Cyp4f3 Cyp4a12 Cyp1a2 Cyp4f40 Cyp1b1 Cyp2u1 Cyp4f4 Cyp2c66 Cyp4f1 Cyp2c11 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) Rif1 Polm Rnf8 Paxip1 Dclre1c Pias4 Ube2n Mre11 Nsd2 Kat5 Rad50 Nbn Lig4 Babam1 Babam2 Ube2v2 Brca1 Bard1 Hist1h2bq Uimc1 Prkdc Poll Nhej1 Xrcc6 Tdp2 Xrcc5 Tdp1 Xrcc4 Hist3h2ba Atm Tp53bp1 Brcc3 ENSRNOG00000066901 Herc2 H2bc4 Rnf168 Hist1h4m H2bc1 ABRAXAS1 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-73930.1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Polb Apex1 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%10222413 Nervous system development Erbb2 Gsk3b Frs2 Prkcq Ranbp9 Tln1 Rasa1 Fgfr1 Creb1 Ret Spta1 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Sema5a Mapk3 Sptan1 Sptbn5 Artn Ptprc Rps6ka5 Gfra1 Nras Sptbn4 Grb2 Gfra2 Gfra4 Fyn Kras Sos1 Hras Sdc2 Mapk7 Arpc3 Arpc2 Map2k2 Sema4d Plxnb1 Map2k1 Arpc5 Arpc4 Dnm2 Nrp1 Efna1 Egfr Efna2 Epha1 Shc3 Epha3 Hsp90ab1 Epha4 Pspn Epha5 Epha6 Epha7 Epha10 Efna4 Dcc Gdnf Efna5 Dpysl2 Arpc1b Kif4b Actr2 Ap2s1 Arpc1a Kif4a Actr3 Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Nrtn Arhgef28 Numb Sh3gl2 Ezr Itgav Rhoc Cd72 Plxnb3 Sema6d Crmp1 Plxna4 Myo9b Plxna3 Shank3 Itga2b Plxna2 Rras Tyrobp Met Plcg1 Sema4a Dpysl3 Dpysl4 Dpysl5 Plxnc1 Arhgap35 Sema3a Sema7a Fes Trem2 Sema3e Itgb1 Plxna1 Grb10 Itgb3 Sdcbp Efnb1 Arhgef7 Rock2 Efnb2 Rock1 Efnb3 Plxnd1 Ephb1 Dscaml1 Ephb2 Ntn4 Ephb3 Dscam Ephb4 Ephb6 Unc5a Nck2 Rac1 Pak3 Rnd1 Git1 Hsp90aa1 Sh3kbp1 Limk1 Dok1 Nck1 Actb Itga9 Mmp2 Mmp9 Lypla2 Gap43 Mapk1 Grb7 Prkaca Prkacb Pdlim7 Dok4 Dok5 Prkca Dok6 Cdk5r1 Ank1 Pak1 Pak2 Cdk5 Lyn Nfasc Yes1 Src Rlc-a Rhoa Ngef Grin1 Grin2b Adgrg6 Epha2 Reln Dab1 Rhob Rap1gap Dok2 Csnk2a2 Csnk2a1 Actg1 Csnk2b Pik3ca Tiam1 Shc1 Gab2 Farp2 Pip5k1c Pik3r1 Arhgef11 Pik3cb Arhgef12 Vav3 Pik3r2 Pik3r3 Vav2 Pik3cd Itsn1 Ptpn11 Psenen Psen1 Psen2 Kalrn Ncstn Aph1a Gab1 Aph1b Irs2 St8sia4 Vldlr Trio St8sia2 Ap2m1 Clta Cltc Dnm1 Cdc42 CO-INHIBITION BY CTLA4%REACTOME%R-RNO-389513.1 Co-inhibition by CTLA4 Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Akt3 Lyn Akt2 Yes1 Akt1 Src Ppp2r5e Cd86 Fyn Cd80 Ptpn11 Ppp2r5d Lck Ctla4 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange Mre11 Kat5 Rad51 Rad50 Nbn Rad51c Rad51b Chek1 Rbbp8 Brca2 Brca1 Rad51ap1 Bard1 Top3a Palb2 Xrcc3 Xrcc2 Atm Exo1 Rmi2 Rmi1 Blm Brip1 Wrn Dna2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-RNO-193692.1 Regulated proteolysis of p75NTR Aph1b Nfkb1 Adam17 Psenen Ngfr Psen1 Psen2 Ncstn Aph1a Rela Traf6 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223929 Activation of Ca-permeable Kainate Receptor Grik5 Grik2 Grik1 Grik4 Calm3 Grik3 Ncald Dlg1 Dlg3 Dlg4 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-RNO-5624138.1 Trafficking of myristoylated proteins to the cilium Unc119b Rp2 Nphp3 Arl3 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224173 Ca activated K+ channels Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Kcnn2 Kcnma1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10224539 WNT ligand biogenesis and trafficking Wnt11 Wnt4 Wnt2b Wnt16 Wnt1 Wnt5a Vps26a Vps35 Vps29 Wnt10a Wnt10b Wls Wnt9a Wnt9b Wnt7a Tmed5 Snx3 Wnt5b Wnt8b Wnt6 Wnt8a Wnt2 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%10222293 Synthesis of PA Agpat3 Ddhd2 Agpat4 Agpat1 Agpat2 Alpi Lclat1 Pla2g2d Pla2g2f Pla2g2a Gnpat Pla2g1b Pla2g4d Pla2r1 Pla2g12a Lpcat4 Pla2g10 Pld2 Pla2g5 Lpcat1 Pld1 Gpd1l Miga2 Gpat2 Miga1 Gpd1 Gpam Gpd2 Pld6 Pla2g4a Liph Lipi Pla2g4b Acp6 Gpat4 Gpat3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 96%10224349 Pre-NOTCH Processing in Golgi Tmed2 Notch4 Notch3 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation Hsf1 Ywhae Eef1a1 Hsp90ab1 Ptges3 Vcp Hsp90aa1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane Rab14 Ocrl Inpp5j Synj1 Pik3c2g Inpp5d Pik3ca Mtmr1 Pip5k1c Arf1 Pik3r1 Pik3cb Pik3r2 Synj2 Pik3r3 Inppl1 Pik3cd Ptpn13 Pi4k2b Inpp4a Inpp4b Pik3c2a Plekha8 Mtm1 Pik3r5 Pik3cg Pi4k2a Pip4k2b Pip4k2c Pip4k2a Rab5a Pten Rab4a Pip5k1b Pip5k1a Mtmr14 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Mtmr3 Rufy1 Inpp5k Pik3c2b Bmx Mtmr6 Mtmr9 Pik3r6 OLEOYL-PHE METABOLISM%REACTOME%R-RNO-9673163.1 Oleoyl-phe metabolism Pm20d1 G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 96%10224125 G0 and Early G1 E2f5 Dyrk1a Tfdp2 Tfdp1 Ccna1 Lin52 Ccna2 Rbbp4 Rbl2 Lin54 Cdk2 Rbl1 Ccne1 Ccne2 Lin9 Lin37 Hdac1 E2f4 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%10222775 Insulin effects increased synthesis of Xylulose-5-Phosphate Taldo1 Tkt TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222799 TRIF (TICAM1)-mediated TLR4 signaling Ppp2cb Ppp2ca Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Rps6ka1 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Birc2 Optn Rps27a Ptpn11 Skp1 Uba52 Ube2d1 Btrc Ubb Ubc Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%10222391 GRB2 events in EGFR signaling Grb2 Egfr Egf Kras Sos1 Hras Ereg Tgfa Areg Hbegf Btc Nras SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193368.1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Hsd3b7 Ncoa2 Akr1d1 Amacr Baat Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Akr1c19 Nr1h4 Akr1c21 Scp2 Cyp27a1 Slc27a5 Cyp7a1 Acox2 Abcb11 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Hsd17b4 Akr1c9 Slc27a2 Acot8 Rxra TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-RNO-174430.1 Telomere C-strand synthesis initiation Acd Terf1 Terf2ip Tinf2 Pot1 Pola2 Pola1 Prim2 Prim1 Ctc1 Stn1 Ten1 Terf2 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System Prkcq Cfp Fuca1 Rap1a Rap1b Bcl2l1 Mmtag2 Nbeal2 Prdx4 Plac8 Pgrmc1 Commd9 Golga7 Retn Lgals3 Ptprn2 Bin2 Cd36 Pa2g4 S100a11 S100a9 Dynlt1 Gmfg Syngr1 Clec4a3 Clec4a2 Glipr1 Man2b1 Tmc6 Clec4b2 Grn Ceacam6 Enpp4 Fcer1a Cgm4 Ypel5 Txk Ppp3ca Nfam1 Clec6a-ps1 Ppp3cb Itk Aga Commd3 Nfatc1 Pigr Nfatc3 Pygb Nfatc2 Crispld2 Ppp3r1 Grap2 Ormdl3 Lamtor3 Ms4a2 Dnajc13 Lamtor2 Lilrc2 Tec Rab44 Adgrg3 Vcl Ear1l1 Chrnb4 Epx Kcmf1 Tom1 Serpinb1a Rab37 Serpinb12 Ist1 Serpinb10 Psgb1 Pkp1 Dsc1 Bri3 Gpr84 Ptprb Ghdc Lamp1 Arl8a Rab3d Nit2 Chi3l1 Lat Mospd2 Acp3 Slc2a5 Alad Crisp2 Olfm4 Atad3a Fgl2 Dnase1l1 Hgsnat Mnda Fgb Fga Frmpd3 Rnase17 Fgg Agpat2 Fcgr3a Mcemp1 Scamp1 Tmem179b Cant1 Unc13d Cpne1 Cpne3 Tmem30a Rnase2 Rnase3 Pld4 Vat1 Mapk12 Tspan14 Prg3 Anpep Atp6v0b Prg2 Bst2 Atp6v0a4 Rap2b Rap2c Atp6v1g3 Manba Cap1 Atp6v0e2 Atp6v1c2 Mlec Cd53 Atp6v0a1 Atp6v1c1 Stk11ip Svip Atp6v0c ENSRNOG00000064486 Qpct ENSRNOG00000064129 Tlr9 Irag2 Cstb Gca Atp6v1e2 Erp44 Creg1 Atp6v1e1 Tcirg1 Cd68 Atp6v1a Dok3 Atp6v1b2 Hebp2 Cd93 Atp6v0d2 ENSRNOG00000067708 Atp6v0d1 Atp6v1b1 Cotl1 Dpp7 Atp6v0e1 Tarm1 Atp6v1g2 Degs1 Atp6v1g1 Atp6v1f Ggh Atp6v1d Cnn2 Nme2 Psg29 Dnajc5 Ddx3x Cracr2a Clec4a Clec4d Cpped1 Mvp Ms4a3 Pdap1 Kcnab2 Oscar Tmem63a Cmtm6 Tnfaip6 Vps35l Ostf1 Ap1m1 Ptx3 Vamp8 Slc44a2 Txndc5 Hspa8 Cab39 Lamtor1 Cd180 Ly86 Ptpn4 Tasl Eea1 Tlr10 Irf5 RT1-M6-2 Mgst1 Cdc34 B2m Gstp1 Atg7 RT1-M10-ps1 RT1-M10-ps5 Snap23 Pak1 RT1-N3 Pak2 Apeh RT1-M1-2 RT1-M1-5 Mre11 Rt1-ec3 Huwe1 Ncf1 Ncf2 Ncf4 Ube2m Xrcc6 Xrcc5 RT1-M5 Ubr4 RT1-M2 Unc93b1 Lgmn Tlr8 Cnpy3 Padi2 Cyba Cybb Uba3 Myo5a Trim21 Dync1h1 Trim32 AABR07044308.1 Lpcat1 Clec7a Card9 Gpi Arg1 Dync1li1 Aoc1 Dynll1 Pgam1 Aldoc Aldoa Pfkl Pdpk1 ENSRNOG00000070986 Lat2 Ctnnb1 Pkml1 Hk3 Hspa1b Hspa1a Clec4e Ptprc S100a1 Gsdme Tlr1 Gsdmd Tlr7 Tlr6 Lbp S100a8 Tlr2 Ctsb Arhgap45 Ctss Dnm2 Jup Stom Impdh2 Pycard Panx1 Txnip Arhgap9 Impdh1 Sugt1 Nlrp3 Txn Pld1 Mefv Pstpip1 Nlrp1a Hsp90ab1 P2rx7 Stk10 Tbk1 Irf3 Mavs Faf2 Rig1 Tax1bp1 Ikbke Cyld Diaph1 Gns C1qbp Galns Hexb H2az1 Krt1 Prcp Stbd1 Dock2 Myo9b Plcg1 Pla2g2a Sdcbp Rock1 Dhx36 Rac1 Pak3 Psma4 Psma3 Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Psmb1 Psmb3 Psmb2 Myh9 Uba52 Myo10 Ube2d1 Btrc Psma7 Nck1 Ilf2 Psmc5 Actb Psmc2 Psmc1 Srp14 Psmc4 Psmc3 Dhx9 Ubb Ubc Psmb6l1 Psmd7 Casp1 Psmd6 Psmd8 Mmp9 Psmd2 Psmd1 Adrm1 Cul1 Nos3 Mapk1 Fabp5 Ppp2cb Ppp2ca Prkaca Prkacb Prkcd Gusb Calm3 Ppp2r5d Tollip Ppp2r1b Il1b Ppp2r1a Nfasc Ctsc Copb1 Serpina1 Actr10 Hbb Ctsh Cd59 Ckap4 Idh1 H2ab2 H2ac4 Abl1 ENSRNOG00000066901 Stat6 Hsp90b1 Crebbp H2ac18 Ctsk Ctsl Actg1 Hist1h2bq Csnk2b H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Itch Vav3 Vav1 Vav2 Ptpn11 H2bc18 Psen1 H2bc4 Hist1h4m Ncstn H2bc1 Hist1h2ai Neu1 Myo1c Casp2 Myd88 Glb1 Ctsa Dnm1 Vcp Cdc42 Slco4c1 Ddost Magt1 Ppie Ube2d3 Ube2d2 Acaa1b Creb1 Slc27a2 Ptk2 Mapk3 Sptan1 Ddx41 Rps6ka5 Nras Sting1 Grb2 Fyn Kras Sos1 Mapk13 Hras Nkiras1 App Mapk9 Atf2 Tnfrsf1b Ikbkb Atf1 Slc15a4 Mapk7 Nkiras2 Iqgap2 Mapk8 Traf6 Peli1 Ikbkg Cat Map3k8 Map3k7 Ube2n Relb Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Vrk3 Vapa Alpk1 Rela Rps6ka3 Map3k1 Peli2 Nos2 Rps6ka1 Peli3 Map3k14 Tifa Ptges2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Kpnb1 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Armc8 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Cep290 Tab2 Dnm3 Usp18 Ap2a2 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Tubb5 Itgav Chit1 Tubb4b Cdk13 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Snap29 Masp1 Masp2 Rbsn C4b C1qb Crp C1qa Cfh Cfi C2 Elane C4 Hp Colec10 C6 C9 Cd46 Cfhr1 C1s C1r Optn Cpn1 Cpn2 Cd19 Rab31 C1qc Fth1-ps5 Pik3c3 Pafah1b2 Pik3r4 Fth1 Rab3a Ftl1 Plcg2 Itgax Gdi2 Pla2g6 Rab7a Prkce Cfd A1bg Rab27a Hrg Olr1 Tbc1d10c Trappc1 Rab6a Ceacam1 Rab5c Ahsg Crk Rab5b Serpina3n F12 Serpinb6a Rab9b Rab10 Igf2r Rab14 Rab18 Nlrp4 Dtx4 Anxa2 Qsox1 Gsn Sh3glb2 Plpp4 Lamp2 Plpp5 Pld3 Pnp Cd177 Ampd3 Aprt Lyn Yes1 Src Rhoa Lrrc7 Itgal Eef2 Itgb2 Lcp2 Lpo Arsa Mpo Cd3g P2rx1 Asah1 Gm2a Aamp Trem1 Cd4 Mif Lck Gla Arsb Raf1 Orm1 Rhog Rac2 Ano6 Rab4b Atp6ap2 Cd47 Ctsd Mme Ctsg Cd63 Cand1 Ctsz Prtn3 Cpb2 Ppia Aim2 Fcer1g Birc2 Sell Sirpa Plau Pecam1 Nos1 Pik3ca Shc1 Npc2 Ptpn6 Gab2 Pik3r1 Pik3cb Plaur Pik3r2 Fuca2 Trpm2 Bpifb2 Alox5 Lta4h Cst3 Atp11b Atp11a Atp8b4 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 Hmox2 Hpse Nckap1l Wipf3 Wipf1 Ripk3 Ripk1 Capza1 Capza2 Apob Fadd Abi2 Abi1 Ttr Arpc3 Arpc2 Arpc5 Arpc4 Dgat1 Brk1 Dsp Dsg1 Elmo1 C3ar1 Wasf3 Wasf2 Wasf1 Cd209a Arpc1b Actr2 Mmp25 Arpc1a Ppbp Actr3 Fpr1 Btk Adam10 Fpr2 C3 Nckap1 C5 Cyfip2 Cyfip1 Rhof Adam8 Mmp8 Try10 Prss2l1 Nckipsd Tyrobp Klkb1 Try5 Trem2 Cd44 LOC102554637 Pld2 Elmo2 Capn1 Timp2 Prss2 Acly Prss3 Prss1 Baiap2 Ccr6 A2m Eef1a1 Limk1 F2 Pdxk Bst1 Vnn1 Ptafr Naprt Slc2a3 Tomm70 Cyb5r3 Dera Pgm2 Cd55 Clec5a Siglec15 Siglec10 Klrd1 Klrc2 Klrk1 Klrc1 Cxcr1 Apaf1 Cxcr2 Folr2 Cda C5ar2 C5ar1 Atp7a Defb41 Defb42 Np4 Defb43 Defb44 Kng1 Defa24 Svs3b Ear1 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Pglyrp2 Reg3a Reg3b Pglyrp3 Pglyrp4 Defa31 Stath Reg3g Bpi Defa Camp Chga Ltf Lyz1 Ndufc2 Bpifa1 Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Defb24 Defb1 Slc11a1 Defb25 Eppin Aldh3b1 Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Malt1 Bcl10 Snap25 Psap Tirap Actr1b Siglec5 Siglec8 Adgre5 Cct2 Cxcl1 Lair1 Cct8 Gaa Agl Pygl Gyg1 Pgm1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr ENSRNOG00000065564 Frk Hck Prdx6 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 Casp9 AABR07065812.2 ENSRNOG00000063707 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Icam2 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Hvcn1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223465 Regulation of insulin secretion Adcy5 Kcnb1 Adcy6 Kcns3 Kcnc2 Kcng2 Prkaca Prkacb Gnai2 Gnai1 Prkca Cacna1c Gna11 Cacna1d Gna14 Marcks Gng3 Gng5 Gng4 Gnaq Gng7 Cacnb3 Gng8 Cacna1e Gngt1 Cacnb2 Itpr3 Cacna1a Itpr2 Slc2a2 Itpr1 Cacna2d2 Ffar1 Gnb2 Abcc8 Gnb1 Kcnj11 Gnb4 Gnb3 Gnb5 Gng11 Rap1a Gnas Acsl3 Acsl4 Cd36 Adra2a Adra2c Rapgef4 Rapgef3 Slc2a1 Gcg Plcb3 Glp1r Plcb2 Plcb1 Gng10-ps1 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%10224057 N-glycan trimming and elongation in the cis-Golgi Man1a2 Man1a1 Mgat1 Manea Man1c1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-RNO-174437.1 Removal of the Flap Intermediate from the C-strand Acd Terf1 Fen1 Terf2ip Pold2 Pold1 Tinf2 Pot1 Pcna Pold4 Pold3 Rpa1 Rpa2 Wrn Rpa3 Terf2 Dna2 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%10223253 ERK MAPK targets Dusp7 Dusp6 Ppp2cb Ppp2ca Mapk14 Ppp2r1b Ppp2r1a Mapk3 Vrk3 Rps6ka5 Rps6ka3 Mapk1 Rps6ka1 Rps6ka2 Ppp2r5d Mapk11 Mapk7 Dusp3 Dusp4 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination Fignl1 Rad51 Dmc1 Firrm VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%10225013 VLDL clearance Apobr Vldlr Apob Apoc1 Apoc4 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-RNO-4085377.1 SUMOylation of SUMOylation proteins Nup133 Sumo3 Nup210 Nup155 Pias4 Nup153 Ube2i Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Sumo1 Nup214 RESPONSE TO METAL IONS%REACTOME%R-RNO-5660526.1 Response to metal ions Mt2 Mt3 NEUREXINS AND NEUROLIGINS%REACTOME DATABASE ID RELEASE 96%10224893 Neurexins and neuroligins Shank1 Shank3 Cask Homer1 Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Epb41l2 Epb41l3 Epb41l5 Lrrtm1 Lrrtm2 Lrrtm3 Lrrtm4 Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Sh3glb2 Nlgn3 Grm1 Grm5 Epb41l1 Dlg2 Dlg3 Dlg4 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693565.1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Rnf8 Pias4 Ube2n Mre11 Ube2i Uba52 Nsd2 Kat5 Rad50 Nbn Eya2 Eya1 Eya4 Babam1 Eya3 Baz1b Babam2 Chek2 Ubxn1 Ube2v2 Brca1 Bard1 Hist1h2bq Uimc1 Ubb Ubc Tp53 Hist3h2ba Atm Bap1 Tp53bp1 Apbb1 Rps27a Kdm4b Kdm4a Abl1 Brcc3 ENSRNOG00000066901 Smarca5 Ppp5c Herc2 H2bc4 Rnf168 Hist1h4m Mapk8 Sumo1 H2bc1 ABRAXAS1 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%10223869 RHO GTPases activate PAKs Ppp1r12a Flna Pak1 Calm3 Rac1 Pak3 Pak2 Cdc42 Limk1 Ppp1cb Ppp1r12b Mylk DEADENYLATION OF MRNA%REACTOME%R-RNO-429947.1 Deadenylation of mRNA Eif4a2 Eif4a1 Pan2 Paip1 Pan3 Eif4e Pabpc1 Eif4a3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-RNO-72695.1 Formation of the ternary complex, and subsequently, the 43S complex Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Fau Rps6 POTASSIUM TRANSPORT CHANNELS%REACTOME DATABASE ID RELEASE 96%10224177 Potassium transport channels Kcnj16 Kcnj10 Kcnj1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 96%10224201 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-RNO-9758890.1 Transport of RCbl within the body Ldlrap1 Lrpl1 Tcn2 Abcc1 Lrp2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223461 Peptide hormone biosynthesis Fshb Inha Pcsk1 Pomc Lhb Inhba Cga Inhbb Tshb Inhbc Inhbe SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-RNO-111367.1 SLBP independent Processing of Histone Pre-mRNAs Snrpg Ncbp2 Snrpb Ncbp1 Zfp473 Snrpepl2 Lsm10 Lsm11 Snrpf Snrpd3 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-RNO-9933937.1 Formation of the canonical BAF (cBAF) complex Smarcc1 Smarca2 Smarca4 Arid1a Arid1b Actl6a Smarcd1 Ss18 Smarce1 Dpf1 Dpf2 Dpf3 Actg1 Ss18l1 Bcl7a Smarcb1 Bcl7b Bcl7c NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%10223559 Nuclear Receptor transcription pathway Nr1d2 Nr1d1 Vdr Esr1 Nr2c1 Nr1h4 Ppara Nr1i3 Thrb Thra Nr5a1 Nr2f6 Nr0b2 Nr0b1 Nr2f1 Nr2e3 Nrbf2 Nrbf2l1 Med1 Nr1h3 Nr1h2 Rxrb Rxra Pparg Pgr Nek4 Rxrg Rorc Rorb Nr4a1 Esr2 Esrra Rara Esrrb Esrrg Ppard Nr6a1 Nr2c2 Ncor2 Hnf4a Nr1i2 Rarg Hnf4g Nr5a2 Nr4a3 Nr4a2 Ar Nr3c2 Nr3c1 DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins Defa Try10 Tlr1 Prss2l1 Defb14 Defb17 Defb18 Art1 Defb21 Tlr2 Defb5 Defb24 Defb1 Defb25 Try5 Defb28 LOC102554637 Defa9 Cd4 Defa8 Defb30 Defa6 Defa3 Prss2 Prss3 Prss1 Defb41 Ccr6 Defb42 Np4 Defb43 Defb44 Defa24 Defal1 Defa31 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) Pdpk1 Prkaca Prkacb Prkcd Cdc34 Calm3 Ube2d2 Clec4e Pak1 Il1b Pak2 Lyn Src Rps6ka5 Nras Fyn Kras Hras Ikbkb Traf6 Ikbkg Map3k7 Ube2n Relb Nfkb2 Nfkb1 Fbxw11 Rela Ube2m Map3k14 Ppp3ca Ppp3cb Clec6a-ps1 Nfatc1 Nfatc3 Pycard Malt1 Nfatc2 Bcl10 Ppp3r1 Raf1 Casp8 Cd209a Nfkbia Tab3 Tab2 Tab1 Chuk Fcer1g Crebbp Uba3 Pak3 Psma4 Psma3 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Clec4d Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Ube2d1 Syk Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Plcg2 Ubb Ubc Psmb6l1 Psmd7 Icam2 Clec7a Psmd6 Card9 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223937 MAP3K8 (TPL2)-dependent MAPK1 3 activation Ikbkg Map3k8 Uba52 Nfkb1 Fbxw11 Cul1 Btrc Rps27a Tnip2 Chuk Ikbkb Ubb Skp1 Ubc ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 Bdnf Ntrk2 Plcg1 Ntf4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-RNO-1660517.1 Synthesis of PIPs at the late endosome membrane Fig4 Vac14 Mtmr7 Mtmr4 Pik3r4 Pikfyve Pik3c2a Pik3c3 Mtm1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME DATABASE ID RELEASE 96%10222419 Global Genome Nucleotide Excision Repair (GG-NER) Chd1l Sumo3 Ino80 Xpc Ddb2 Cdk7 Ino80e Ino80d Ino80c Ercc1 Ino80b Ercc4 Usp45 Mnat1 Polk Actg1 Rnf111 Ruvbl1 Rad23a Rad23b Sumo2 Cops3 Cops6 Cops8 Rps27a Gps1 Ube2n Gtf2h2 Ube2i Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Cops4 Ercc2 Ercc3 Cops2 Pole3 Pole2 Cops7a Pole4 Cops7b Ube2v2 Rpa1 Rpa2 Mcrs1 Ubb Rpa3 Ubc Pole Parp2 Parp1 Rfc5 Pold2 Nfrkb Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Ccnh Pold4 Tfpt Pold3 Actl6a Actr5 Yy1 Pias3 Actr8 Pias1 Cops5 Xpa Ddb1 Cul4a Sumo1 Cetn2 Cul4b SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%10224287 Sulfide oxidation to sulfate Usf1 Slc25a10 Sqor Ethe1 Suox FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-RNO-9933947.1 Formation of the non-canonical BAF (ncBAF) complex Smarcc1 Smarca2 Smarca4 Actl6a Smarcd1 Ss18 Smarcd3 Bicral Smarcd2 Bicra Brd9 Actg1 Ss18l1 Bcl7a Bcl7b Bcl7c REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%10225549 Regulation of GBP-mediated host defense Casp1 Pim1 Sfn Gbp1 Gbp3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-RNO-202733.1 Cell surface interactions at the vascular wall Jam2 Grb7 Grb14 Jaml Fn1 Itga3 Itga4 Esam Cd177 Lyn Yes1 Src Spn Nras Grb2 Itgal Fyn Kras Apob Sos1 Hras Itgb2 Cd244 Slc3a2 Mertk Atp1b1 Atp1b3 Atp1b2 Thbd Pros1 Trem1 Mif Lck Slc7a11 Slc7a10 Cd48 L1cam Cd47 Bsg Slc7a6 Itga6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Itgav Cd74 Angpt1 F11r Ppia Procr Epcam Dok2 Plcg1 Sele Proc Selp Sell Jchain Cd44 Sirpa Itgb1 Tek Pecam1 Itgb3 Angpt2 Angpt4 Fcamr Inpp5d Pik3ca Shc1 Cav1 Mmp1b Ptpn6 Pik3r1 Pik3cb Pik3r2 Ptpn11 ENSRNOG00000069193 AABR07065813.1 F2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ppil2 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Cxadr Igkvl13 AABR07065812.2 Selplg ENSRNOG00000063707 ENSRNOG00000067679 Itgax ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 Pf4 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 Glg1 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Olr1 ENSRNOG00000067643 Slc16a3 Slc16a8 Slc16a1 Gas6 Mag Ceacam1 Jam3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-RNO-400451.1 Free fatty acids regulate insulin secretion Plcb3 Gna11 Gna14 Plcb2 Plcb1 Cd36 Ffar1 Acsl3 Acsl4 Gnaq ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%10223549 Electric Transmission Across Gap Junctions Gja10 Gjc1 Gjd2 Panx2 Panx1 DEGRADATION OF GABA%REACTOME%R-RNO-916853.1 Degradation of GABA Aldh5a1 Abat SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema3a Tln1 Fyn Nrp1 Plxna4 Plxna3 Plxna1 Farp2 Plxna2 Pip5k1c PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-RNO-428559.1 Proton-coupled neutral amino acid transporters Slc36a1 Slc36a2 ENOS ACTIVATION%REACTOME%R-RNO-203615.1 eNOS activation Nos3 Cygb Zdhhc21 Cav1 Calm3 Ddah1 Cyb5b Akt1 Spr Lypla1 Hsp90aa1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-RNO-8963889.1 Assembly of active LPL and LIPC lipase complexes Lipc Angptl3 Furin Pcsk5 Angptl8 Pcsk6 Lmf1 Lpl Lmf2 Gpihbp1 Angptl4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-RNO-69202.1 Cyclin E associated events during G1 S transition Ccnd1 Cdk7 Mnat1 Psma4 Ccna1 Psma3 Akt3 Ccna2 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Skp2 Skp1 Psmb5 Psmb4 Ptk6 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Cks1b Cables1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Wee1 Ubb Ubc Psmb6l1 Cdkn1b Psmd7 Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Ccnh Cdk2 Cdk4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%10222481 Post NMDA receptor activation events Creb1 Rps6ka6 Prkar2a Camk1 Prkar2b Prkaca Prkacb Rps6ka3 Camk4 Rps6ka1 Prkar1a Prkar1b Rps6ka2 Calm3 Camkk1 Camkk2 CS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022870.1 CS-GAG biosynthesis Bcan Vcan Chst3 Ust Ncan Cspg5 Bgn Dcn Cspg4 Chst15 Chst11 Chst12 Chsy1 Chsy3 Chst13 Chpf Csgalnact2 Chst7 Chst9 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224813 MAP2K and MAPK activation Il17rd Apbb1ip Fgb Fga Ksr1 Fgg Arrb2 Wdr83 Arrb1 Itga2b Araf Cnksr2 Map2k2 Csk Map2k1 Tln1 Pebp1 Fn1 Itgb3 Lamtor3 Lamtor2 Raf1 Vcl Braf Mark3 Mapk3 Src Nras Mapk1 Kras Rap1a Rap1b Hras Ywhab REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 96%10224531 Regulation of TP53 Activity through Association with Co-factors Zfp385a Tp53bp2 Phf20 Akt3 Akt2 Pou4f1 Akt1 Pou4f2 Banp Ppp1r13l Tp63 Ppp1r13b Tp73 Tp53 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 96%10225351 STAT3 nuclear events downstream of ALK signaling Hdac2 Stat3 Hdac3 Hdac1 Ep300 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10225097 RUNX1 regulates transcription of genes involved in interleukin signaling Cbfb Elf1 Runx1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%10223237 AKT phosphorylates targets in the cytosol Cdkn1b Akt1s1 Mkrn1 Tsc2 Chuk Casp9 Akt3 Akt2 Akt1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 96%10222219 Insulin receptor signalling cascade Ins2 Pdpk1 Frs2 Trib3 Grb10 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Shc1 Insr Fgf19 Gab2 Fgf10 Mapk3 Akt2 Pik3r1 Pik3cb Pik3r2 Grb2 Sos1 Ptpn11 Fgf20 Fgf23 Fgf22 Pik3c3 Gab1 Irs2 Pik3r4 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Mapk1 Kl Flt3 Ins1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%10223033 Signaling by FGFR Ppp2cb Ppp2ca Hnrnph1 Frs2 Spred1 Plcg1 Frs3 Spred2 Fgfrl1 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Fgfbp3 Fgf17 Fgfbp1 Pik3ca Fgf18 Shc1 Fgf19 Braf Rbfox2 Ppp2r1a Esrp2 Fgf10 Esrp1 Mapk3 Tial1 Tia1 Pik3r1 Src Spry2 Mknk1 Nras Rps27a Grb2 Kras Sos1 Polr2c Hras Polr2a Ptpn11 Polr2b Fgf20 Polr2g Fgf23 Polr2h Polr2e Fgf22 Polr2f Polr2i Gab1 Polr2j Ncbp2 Ncbp1 Tgfbr3 Uba52 Gipc1 Gtf2f2 Hnrnpa1 Gtf2f1 Klb Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Flrt1 Fgf7 Ubc Flrt3 Fgf9 Flrt2 Ptbp1 Cbl Mapk1 Hnrnpf Kl Galnt3 SIGNALING BY EGFR%REACTOME%R-RNO-177929.1 Signaling by EGFR Spry1 Ereg Uba52 Ptpn12 Plcg1 Btc Ptpn3 Csk Egf Eps15 Aamp Ubb Arhgef7 Ubc Hgs Pxn Eps15l1 Egfr Pik3ca Shc1 Fam83b Hbegf Pag1 Src Lrig1 Spry2 Pik3r1 Cbl Nras Rps27a Stam2 Fam83a Grb2 Fam83d Kras Epn1 Sos1 Sh3gl3 Hras Ptpn11 Sh3kbp1 Tgfa Stam Cdc42 Sh3gl2 Areg Sh3gl1 Gab1 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Crebbp Irf3 Ctnnb1 Ep300 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%10224387 MHC class II antigen presentation Lgmn Lag3 Actr1a Dctn1 Dctn2 Ifi30 Dctn4 Rilp Ctse Ctsf Ctso Racgap1 Ctsk Ctsl RT1-DOa Sec23a RT1-DOb Kif3a Kif26a RT1-DMb Kif11 Canx Kif15 Kif5a Kif5b Sptbn2 Ctsc Arf1 Sar1b Kif22 Sec31a Kif23 Ap1b1 Kif18a Kif20a Klc1 Ap1m2 Dync1h1 Kifap3 Ap1m1 Ap1s3 Klc4 Ap1s2 Actr10 Klc3 Dync1i2 Sec24d Klc2 Ap1g1 Sec24c Dync1i1 Sec24b Sec24a Kif3b Ctsb Ctsh RT1-Db2 Ctss Kif3c RT1-Db1 Dnm2 RT1-Ha RT1-Ba RT1-Bb Ap2m1 Rab7a RT1-Da Clta Ctsa Cenpe Cltc Dnm1 Kif2a Sec13 Kif2b Kif2c Dync1li2 Kif4b Dync1li1 Ap2s1 Kif4a Actr1b Dynll1 Ctsd Dynll2 Dnm3 Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Cd74 Osbpl1a ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223663 Association of TriC CCT with target proteins during biosynthesis Cct5 Sphk1 Cct4 Tcp1 Cct6b Cct7 Cct3 Cct6a Cct2 Cct8 ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells Kras Hras Rasgrp1 Nras DOWNSTREAM TCR SIGNALING%REACTOME%R-RNO-202424.1 Downstream TCR signaling Pdpk1 Prkcq Cdc34 Ube2d2 Inpp5d Pik3ca Psma4 Psma3 Psma6 Pik3r1 Psma5 Pik3cb Psma2 Psma1 Rps27a Pik3r2 Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Traf6 Psmb7 Psmb6 Ikbkg Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Uba52 Nfkb1 Pten Ube2d1 Fbxw11 Btrc Psma7 Rela RT1-Db2 Cd3g Psmc5 Cd247 Psmc2 RT1-Db1 Psmc1 Cd3e Psmc4 Cd3d Psmc3 Trav19 AC109737.1 Cd4 RT1-Ha Trat1 Lck RT1-Ba RT1-Bb Ubb ENSRNOG00000065955 Malt1 Ubc Trbv16 Bcl10 RT1-Da Ripk2 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Nfkbia Tab2 Chuk ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222041 Alanine metabolism Gpt2 Gpt CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%10225271 Class I peroxisomal membrane protein import Pxmp2 Fis1 Abcd1 Acbd5 Abcd2 Gdap1 Aldh3a2 Abcd3 Pex26 Pex11b Pex2 Atad1 Pex14 Pex13 Pex12 Pex19 Pex16 Pex3 Pxmp4 PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling Suz12 Erbb2 Eed Erbb3 Ereg Pdpk1 Frs2 Rbbp4 Btc Rbbp7 Tnks2 Pdgfa Pdgfb Xiap Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Creb1 Fgf17 Fgf18 Fgf19 Fgf10 Hbegf Mapk3 Ntrk3 Ntf3 Stub1 Rnf146 Grb2 Fyn Tnks Tgfa Fgf20 Wwp2 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Lamtor3 Lamtor2 Hgf Egfr Hdac2 Irak1 Pdgfrb Pdgfra Chuk Kl Flt3 Nrg2 Nrg3 Met Prex2 Egf Trib3 Them4 Insr Rac1 Psma4 Akt3 Psma3 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Chd3 Cd19 Rps27a Chd4 Psmd12 Psmd11 Tsc2 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Psmb5 Gatad2a Psmb4 Gatad2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Strn Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Cdkn1b Psmd7 Rptor Psmd6 RragB Psmd8 Psmd2 Psmd1 Mtor Adrm1 Rheb Slc38a9 Mapk1 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Pik3r6 Rragd Mlst8 Ins1 Ppp2cb Ins2 Ppp2ca Foxo4 Nedd4 Il33 Ppp2r5d Usp7 Il1rap Irak4 Mkrn1 Ppp2r1b Ppp2r1a Src Otud3 Pten Usp13 Lck Rhog Rac2 Ring1 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Esr1 Phc3 Csnk2a2 Trim27 Csnk2a1 Bmi1 Hdac1 Maf1 Mecom Sall4 Csnk2b Pik3ca Gab2 Pip5k1c Pik3r1 Pik3cb Rnf2 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pml Pik3r5 Pik3cg Ier3 Irs2 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Rps6kb2 Pik3ap1 Foxo6 Cd28 Icos Sgk1 Nr4a1 Ntf4 Pip5k1a Frk Rictor Cd86 Cd80 Prr5 Bdnf Il1rl1 Trat1 Casp9 Myd88 Mapkap1 Ntrk2 Foxo1 Ezh2 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224757 Lactose synthesis Slc2a1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding Csnk2b Sphk1 Rgs7 Pdcl Tcp1 Cct6b Cct7 Cct6a Gnb2 Gnb1 Gnb4 Cct8 Gnb3 Cct5 Gnb5 Cct4 Csnk2a2 Csnk2a1 Cct3 Cct2 Rgs9 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%10224675 Phase 0 - rapid depolarisation Cacna1c Cacng8 Cacnb1 Cacng6 Cacng7 Cacnb2 Cacng4 Cacna2d2 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 96%10223431 PRC2 methylates histones and DNA Suz12 Hist1h2ai Eed Dnmt1 Rbbp4 Rbbp7 H2ac18 Phf19 Hist1h2bq Mtf2 Ezhip Aebp2 Ezh1 H2aj Epop H2ab2 H3-3b Hist3h2ba H2ac4 ENSRNOG00000068602 H2bc18 Dnmt3a ENSRNOG00000066901 H2az2 H2bc4 Ezh2 Hist1h4m Jarid2 H2bc1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events Iws1 Cdk7 Ell Ccnk Tcea1 Ccnt2 Ssrp1 Eloa2l Mnat1 Eloa Aff4 Taf9 Taf9b Taf15 Supt6h Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Taf7l-ps1 Gtf2a1 Gtf2a2 Cdc73 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Gtf2e2 Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Mllt3 Ncbp2 Mllt1 Ncbp1 Gtf2h2 Leo1 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Cdk9 Skic8 Eaf1 Eaf2 Ccnh Ctr9 Paf1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222071 Branched-chain amino acid catabolism Acad8 Auh Bckdk Mccc1 Echs1 Hibadh Mccc2 Dld Glyat Ppm1k Ivd Dbt Crat Bcat1 Bcat2 Hibch Aldh6a1 Hsd17b10 Bckdhb Acat1 Bckdha Acadsb EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-RNO-9619665.1 EGR2 and SOX10-mediated initiation of Schwann cell myelination Adgrg6 SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 96%10225437 Signaling by TGFBR3 Tgfb2 Aph1b Mmp16 Timp2 Tgfbr3 Gipc1 Arrb2 Inha Arrb1 Tgfbr1 Tgfbr2 Inhba Fgf2 Psenen Psen1 Psen2 Acvr2a Ncstn Mmp14 Aph1a Timp1 Tgfb1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Rab8a Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Optn Rps27a Pafah1b1 Ccnb2-ps2 Skp1 Ppp1r12b Dync1h1 Ppp1r12a Ccnb1 Csnk1d Ccp110 Uba52 Dync1i2 Fbxw11 Btrc Ppp1cb Aurka Ajuba Nde1 Nedd1 Haus7 Tuba1a Haus8 Ubb Cdk5rap2 Cep192 Ubc Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Cul1 Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Bora Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Ccnb2 Odf2 Ckap5 Alms1 Csnk1e Cetn2 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223691 Activation of AMPA receptors Gria4 Gria3 Gria2 Gria1 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190840.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-RNO-444411.1 Rhesus glycoproteins mediate ammonium transport Rhcg Rhbg Rhag CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-RNO-420499.1 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r16 Tas2r13 Tas2r135 Tas2r136 Tas2r140 Tas2r105 Tas2r145 Tas2r107 Tas2r119 Tas2r39 Tas2r4 Tas2r38 Tas2r3 Grm1 Grm3 Grm2 Tas2r7 Grm5 Gabbr1 Grm4 Grm7 Grm6 Casr Gabbr2 Grm8 Gprc6a Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r40 Tas2r41 RHOB GTPASE CYCLE%REACTOME%R-RNO-9013026.1 RHOB GTPase cycle Ophn1 Pcdh7 Myo9b Myo9a Actc1 Arhgap35 Vamp3 Racgap1 Dlc1 Stard13 Pkn2 Rock2 Rock1 Pkn1 Snap23 Tjp2 Arhgap32 Mcf2l Cav1 Arhgdig Flot2 Arhgef17 Flot1 Arhgef11 Pik3r1 Arhgef10 Arhgef12 Pik3r2 Akap13 Vav2 Arhgef25 Tfrc Arhgef5 Arhgef2 Arhgef1 Abr Slk Cavin1 Daam1 Ect2 Prex1 Bcr Jup Arhgap5 Sowahc Arhgap1 Stom Net1 Arhgef10l Mcam Rtkn Rhpn2 Stk10 Stard8 Rhob Anln Iqgap3 Diaph3 Diaph1 Depdc1b Cit Arhgef28 Arhgap21 Mcf2 Arhgap26 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-RNO-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk1 Kcnk7 Kcnk6 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223239 Regulation of TP53 Degradation Rnf34 Ppp2cb Ppp2ca Phf20 Uba52 Pdpk1 Daxx Sgk1 Rictor Rffl Prr5 Chek2 Usp2 Mapkap1 Ubb Ubc Tp53 Usp7 Ccng1 Ppp2r1b Ppp2r1a Ccna1 Mtor Akt3 Ccna2 Akt2 Akt1 Cdk2 Atm Cdk1 Rps27a Mdm4 Mlst8 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions Fyn Nck2 Kirrel1 Kirrel2 Kirrel3 Nphs1 Nck1 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222073 Histidine catabolism Aoc1 Carns1 Uroc1 Amdhd1 Carnmt1 Ftcd Hal Hdc GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-RNO-5610785.1 GLI3 is processed to GLI3R by the proteasome Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Prkaca Prkacb Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Gli3 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Sufu Skp1 Psmb5 Psmb4 Psmb7 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223883 Interleukin-27 signaling Il27 Canx Jak2 Crlf1 Tyk2 Stat3 Stat1 Il6st Ebi3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222819 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Ly96 Mapk11 Ticam2 Ticam1 Cd14 Tlr4 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Cd274 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cops5 Skp1 Psmb5 Psmb4 Psmb7 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-RNO-8948216.1 Collagen chain trimerization Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Col24a1 Col5a1 Col20a1 Col15a1 Col11a1 Col11a2 Col13a1 Col19a1 Col18a1 Col2a1 Col27a1 Col7a1 Col23a1 Col26a1 Col14a1 Col8a1 Col25a1 Col10a1 Col8a2 SIGNALING BY RETINOIC ACID%REACTOME%R-RNO-5362517.1 Signaling by Retinoic Acid Cyp26a1 Rxrg Rdh11 Rdh10 Akr1c18 Rdh13 Akr1c12l1 Rdh14 Akr1c19 Adh4 Pdha1 Adh1 Akr1c21 Pdha2 Crabp1 Akr1c3l1 Crabp2 Aldh1a1 Akr1c12 Rdh7 Akr1c1 Akr1c13 Rara Akr1c9 Ppard Dld Dhrs4 Pdhx Dhrs3 Aldh8a1 Aldh1a2 Aldh1a3 Cyp26b1 Rarg Pdk4 Pdk3 Fabp5 Dhrs9 Cyp26c1 Dlat Pdk2 Sdr16c5 Pdk1 Pdhb Rxrb Rxra NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975956.1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Ncbp2 Ncbp1 Rpl23a Upf1 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Pabpc1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Etf1 Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Gspt2 Gspt1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225393 Negative Regulation of CDH1 Gene Transcription Suz12 Hist1h2ai Eed Dnttip1 Rbbp4 Rbbp7 H2ac18 Ctbp2 Zeb1 Tle1 Hist1h2bq Hdac1 Mphosph8 Hdac2 H2aj H2ab2 Smarca4 Twist1 H3-3b Hist3h2ba Kmt5a H2ac4 ENSRNOG00000068602 Ctbp1 Sirt1 H2bc18 Zmym2 ENSRNOG00000066901 H2az2 H2bc4 Ezh2 Hist1h4m Kdm1a H2bc1 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%10225073 MET receptor recycling Hgf Grb2 Rab4b Gga3 Arf6 Rab4a Met Crkl Crk Gab1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 96%10222557 Thrombin signalling through proteinase activated receptors (PARs) F2rl2 F2rl3 Arrb2 Arrb1 Gna11 Gna14 Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 F2r Mapk3 Gnb2 Src Gnb1 Gnb4 Gnb3 Mapk1 Gnb5 Gng11 Gng10-ps1 F2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 96%10223303 Synthesis of very long-chain fatty acyl-CoAs Elovl2 Elovl3 Tecr Acsbg1 Elovl5 Elovl1 Elovl6 Acsbg2 Elovl7 Tecrl Hsd17b3 Acsf3 Hsd17b12 Hacd1 Acsl1 Hacd2 Acsl5 Hacd3 Acsl6 Hacd4 Acsl3 Acsl4 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224633 B-WICH complex positively regulates rRNA expression Sf3b1 Hist1h2ai Gsk3b Ddx21 Dek H2ac18 Baz1b Polr1c Myo1c Hist1h2bq Actg1 Kat2a H2aj H2ab2 Tbp Polr1b H3-3b Polr1a Hist3h2ba Polr1f Ep300 H2ac4 Polr1g Polr1e ENSRNOG00000068602 Polr1h Taf1d Mybbp1a Taf1a Taf1c Taf1b H2bc18 Polr2h Kat2b ENSRNOG00000066901 H2az2 Smarca5 Polr2e Polr2f H2bc4 Ercc6 Hist1h4m H2bc1 TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism Slc3a2 Kmo Ido1 Aadat Kynu Kyat1 Slc7a5 Tdo2 Slc36a4 Haao Ido2 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 96%10224533 Regulation of TP53 Activity through Acetylation Pip4k2b Pip4k2c Pip4k2a Rbbp4 Rbbp7 Ing2 Ing5 Brd1 Brpf3 Brd7 Map2k6 Hdac1 Tp53 Hdac2 Pip4p1 Brpf1 Akt3 Akt2 Kat6a Akt1 Ep300 Meaf6 Chd3 Chd4 Mta2 Mbd3 Gatad2a Pml Gatad2b DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 96%10223951 Deposition of new CENPA-containing nucleosomes at the centromere Hist1h2ai Itgb3bp Rsf1 Oip5 Mis18a Rbbp4 Cenpc Rbbp7 Cenpw Cenpa H2ac18 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Hist1h2bq Cenpm Cenpl Cenpk Cenpi Cenph Ruvbl1 Npm1 H2aj H2ab2 Hist3h2ba H2ac4 ENSRNOG00000068602 Knl1 Mis18bp1 Hjurp ENSRNOG00000066901 H2az2 Smarca5 H2bc4 Hist1h4m H2bc1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport Slc22a3 Slc22a2 Slc22a1 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224911 MET Receptor Activation Hgfac Hgf Hpn Spint2 Spint1 Met YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224379 YAP1- and WWTR1 (TAZ)-stimulated gene expression Tead2 Tead4 Wwtr1 Kat2b Tbx5 Yap1 Tead3 TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling Grb7 Pik3ca Shc1 Dok2 Grb14 Pik3r1 Pik3cb Nras Grb2 Pik3r2 Kras Sos1 Hras Ptpn11 Tek Angpt2 Angpt4 Angpt1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%10225311 Estrogen-stimulated signaling through PRKCZ Mapk1 Prkcz Kras Hras Pdpk1 Nras INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-RNO-445095.1 Interaction between L1 and Ankyrins Sptbn4 Spta1 L1cam Sptb Sptbn1 Ank1 Sptbn2 Sptan1 Sptbn5 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%10224969 Interleukin-36 pathway Il1rap Il1rl2 Il1f10 Il36a Il36rn Il36g CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-RNO-9855142.1 Cellular responses to mechanical stimuli Ppp2ca Pdpk1 Stat1 Prkaca Prkacb Gna11 Prkar1a Anxa2 Prkar1b Adm Itgb1 Calm3 Gng3 Itgb3 Gng5 Pkn2 Gng4 Gnaq Gng7 Pde4d Capn2 Gng8 Gngt1 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Ptk2 Capns1 Yap1 Akt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Ikbkb Gnas Calcrl Ikbkg Ppp2r2a Nfkb1 Rela Rictor Prr5 Mapkap1 P2ry2 Vcl Ptpn1 Mtor Ikbke Nfkbia Nos3 Trpv4 Ramp2 Gng10-ps1 Chuk Abl1 Itgav Mlst8 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 96%10222085 Metabolism of lipids Phyh Amacr Eci2 Hacl1 Mlycd Scp2 Prkab2 Gnpat Crat Acox1 Acox2 Ehhadh Acox3 B3gnt5 Pi4kb Pik3c2g Acaa1b Tpte2 Hsd17b4 Hao2 Pecr Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Nudt19 Acot1 Acot2 Acot5 Acot3 Acot4 Acot8 Abcd1 Baat Echs1 Hadh Agps Cbr1 Hmgcl Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Kpnb1 Ormdl3 Mapkapk2 Cyb5b Ch25h Ran Osbpl3 Gpx2 Osbpl2 Osbpl1a Aloxe3 Gpx1 Osbpl7 Osbpl6 Alox12b Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Agpat2 Cyp8b1 Cyp7b1 Slc10a1 Alpi Fabp6 Nr1h4 Abcc3 Cpne1 Stard5 Cpne3 Cyp46a1 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Slc51b Inpp5j Abcb11 Synj1 Akr1b1 Them4 Sbf1 Degs1 Synj2 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 Fig4 Agpat3 Acoxl Slc44a3 Vac14 Mtmr12 Slc44a4 Slc44a5 Pi4k2a Mtmr4 Slc44a1 Cyp24a1 Pik3r4 Cyp27b1 Slc44a2 Rab5a Rab4a Ndufab1 Fdx1 Awat2 Slc22a5 Awat1 Dhrs7b Far2 Far1 Pla2g6 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Tnfaip8l2 Cyp2j16 Tnfaip8l3 Fdps Tnfaip8l1 Plpp6 Rufy1 Cyp4f39 Idi1 Pitpnb Hsd17b7 Cyp2j3 Inpp5k Mvk Cyp4f1 Pik3c2b Fdft1 Cyp4a14 Sqle Mgll Bmx Ebp Cyp4f3 Tnfaip8 Mtmr7 Hmgcs1 Cyp4a12 Mtmr6 Arv1 Cyp4f40 Mtmr9 Ggps1 Cyp4b1 Sc5d Cpt1a Pik3r6 Lbr Mid1ip1 Acat2 Cyp4f4 Thrsp Nsdhl Cpt2 Cyp4a10 Dhcr24 Cpt1b Cyp4a2 Slc25a20 Dhcr7 Lss Tm7sf2 Srebf2 Pmvk Hmgcr Mvd Msmo1 Srebf1 Pcyt2 Cept1 Etnk2 Etnk1 Etnppl Chka M6pr Chkb Rab14 Selenoi Phospho1 Sacm1l Ggt1 Pi4ka Ggt5 Hpgds Pias4 Arsa Ube2i Smpd2 Smpd3 Cyp1b1 Smpd4 Chat Smpd1 Gba1 Gba3 Lhb Cga Gba2 Enpp7 Galc Asah2 Asah1 Sts Gm2a Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 Mecr Mtmr14 Fut2 Fut1 Mtmr3 B3galt4 Cyp21 Cyp11b3 Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Lgmn Sumo3 Hadha Hadhb Acadl Gstm4 Ltc4s Inpp5d Pik3ca Pip5k1c Pik3r1 Pik3cb Pik3r2 Pik3r3 Inppl1 Pik3cd Med1 Cyp11b1 Cyp11b2 Cyp19a1 Plekha8 Pik3r5 Pik3cg Alox12 Cyp3a9 Alox5ap Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Pnpla2 Cyp3a62 Mbtps1 Cyp3a2 Ptgs2 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Stard10 Gpd1l Abhd4 Osbpl10 Miga2 Miga1 Gpd1 Tgs1 Pgp Mboat1 Mboat2 Osbpl5 Pld6 Pla1a Osbpl8 Cpne6 Cpne7 Liph Lipi Cds2 Acat1 Acp6 Gpat4 Gpat3 Lpcat3 Lpcat2 Tmem86b Pnpla8 Plaat1 Plaat5 Agk Ddhd2 Agpat4 Fabp1 Agpat1 Akr1c18 Abcg2 Abcc1 Akr1c12l1 Akr1c19 Hsd3b Hsd17b3 Gc Akr1c21 Cyp17a1 Hsd3b6 A4galt Hsd3b5 Cerk Hsd11b1 B3galnt1 Srd5a3 Hsd11b2 Hsd3b1 Ugcg B4galnt1 Srd5a1 Ugt8 Hsd17b12 Gal3st1 Srd5a2 Hsd3b5-ps1 Serpina6 Akr1c3l1 Lpin3 Akr1c12 Lpin2 Akr1c1 Akr1c13 Alb Akr1c9 Mtmr1 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Lrp2 Plb1 Pip5k1b Akr1b10 Dgat2l6 Dgat2 Dgat1 Pnpla3 Pon3 Pon1 Pld1 Glb1l B4galt5 B4galt6 Glb1l3 Glb1l2 Hexa Hexb Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Ocrl Plbd1 Pla2r1 Pla2g12a Mboat7 Cyp2u1 Pla2g10 Hacd1 Plaat3 Hacd2 Pla2g5 Pld2 Hacd3 Hacd4 Hsd17b8 Dpep1 Dpep2 Mcat Acad11 Elovl2 Acly Stard4 Elovl3 Star Stard6 Acaa2 Elovl5 Cyp11a1 Tspo Elovl1 Fdx2 Elovl6 Fdxr Elovl7 Tecrl Faah Acbd6 Acbd4 Ppt2 Ppt1 Acsf3 Acsf2 Dbi Acot11 Scd1 Acot12 Ptpn13 Acot13 Them5 Acot9 Acot7 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 Fads2 Rxra Ldlrap1 Pon2 Fads1 Sphk1 Acadvl Alox15b Cbr4 Tecr Acsbg1 Tbl1x Pctp Acads Acsbg2 Scap Acaca Fasn Mmut Cubn Hdac3 Tbl1xr1 Ppard Pcca Fabp2 Fabp3 Pccb Fabp4 Gk Ptges3 Fabp7 Mogat1 Ncor2 Pnpla5 Gpat2 Carm1 Pnpla4 Mogat2 FABP12 Gpam Gpd2 Agmo Fabp9 Gykl1 Pla2g4a Fabp5 Mmaa Tafazzin Lclat1 Pomc Oxct2a Acss3 Bdh2 Bdh1 Oxct1 Hmgcll1 Hmgcs2 Aacs Arf3 Arf1 Pten Eci1 Acadm Decr1 Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Acer3 Sgpp2 Plpp2 Plpp3 Plpp1 Sgpp1 Tspoap1 Psap Stard7 Morc2 Vdr Crebbp Inpp5e Ppara Sin3a Sin3b Csnk2a2 Csnk2a1 Mfsd2b Sptssa Cers6 Csnk2b Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Ormdl2 Smarcd3 Ptdss1 Ptdss2 Cidea Pla2g15 Cidec Pla2g4b Hsd17b13 Fitm2 Fitm1 Pip4k2b St8sia5 Pip4k2c Pip4k2a Neu2 Neu3 Neu4 Neu1 St6galnac5 St6galnac6 Pip5k1a St3gal5 St3gal2 St3gal3 Glb1 Ctsa Pip4p1 Prkaa2 Prkag2 Gde1 Pnpla6 Enpp6 Slco1a4 Slco1b2 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance Scarb1 Cubn Amn Apoa1 Hdlbp INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-RNO-512988.1 Interleukin-3, Interleukin-5 and GM-CSF signaling Prkaca Syk Hck Stat5a Stat5b Tec Inpp5d Jak2 Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Lyn Crkl Csf2rb Yes1 Rapgef1 Pik3r1 Pik3cb Cbl Csf2 Jak3 Grb2 Pik3r2 Fyn Pik3r3 Inppl1 Vav1 Pik3cd Sos1 Ptpn11 Crk Ywhaz NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225279 Negative regulation of NOTCH4 signaling Notch4 Akt1 RHO GTPASES ACTIVATE CIT%REACTOME%R-RNO-5625900.1 RHO GTPases activate CIT Rhoc Kif14 Cit Rac1 Prc1 Rhob Dlg4 Rhoa RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%10225043 RUNX1 regulates transcription of genes involved in differentiation of HSCs Cbfb Cdk7 Kmt2a Tcf3 Mnat1 Tal1 Psma4 Psma3 Yap1 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Tcf12 Psmd11 Psmd14 Psmd13 Runx1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Lmo2 Adrm1 Lmo3 Ccnh Gata3 Gata1 Gata2 Abl1 Tp73 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10224999 The role of GTSE1 in G2 M progression after G2 checkpoint Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Gtse1 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Tp53 Psmb6l1 Psmd7 Psmd6 Psmd8 Hsp90ab1 Plk1 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Fkbpl Psma5 Cdk1 Psma2 Hsp90aa1 Psma1 Rps27a Mapre1 Psmd12 Psmd11 Psmd14 Psmd13 Ccnb2-ps2 Ccnb2 Psmb5 Psmb4 Psmb7 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells Foxo1 Akt3 Akt2 Akt1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-RNO-1660661.1 Sphingolipid de novo biosynthesis Sptssa Cers6 Sphk1 Cers5 Cers4 Cers3 Cers2 Sgms1 Abcg2 Sgms2 Sptlc1 Abcc1 Sptlc2 Cyb5b Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Degs1 Ormdl2 Mfsd2b Ormdl3 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines Psmb6 Psmb1 Psmb3 Psmb2 Azin2 Psma7 Amd1 Psmc5 Psmc2 Psmc1 Psmc4 Smox Psmc3 Sat1 Srm Psmb6l1 Psmd7 Agmat Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Odc1 Oaz1 Psmd12 Oaz3 Psmd11 Oaz2 Psmd14 Nqo1 Psmd13 Azin1 Psmb5 Psmb4 Psmb7 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 96%10224181 Phase 4 - resting membrane potential Kcnk5 Kcnk4 Kcnk2 Kcnj4 Kcnk1 Kcnk10 Kcnk16 Kcnk9 Kcnj2 Kcnk7 Kcnj14 Kcnk18 Kcnk6 Kcnj12 Kcnk13 Kcnk12 Kcnk15 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222461 GPCR downstream signalling Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Prkcq Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Lpar5 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 Creb1 Hbegf Mapk3 Nras Grb2 Kras Sos1 Hras App Mapk7 Rps6ka3 Rps6ka1 Rps6ka2 Egfr Rasgrf2 Gna12 Itgb1 Pde3b Akt3 Akt2 Akt1 Prkch Prkce Grk3 Mgll Pik3r6 Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Itpr3 Itpr2 Itpr1 Pak1 Pde10a Daglb Src Rhoa Ngef Trpc7 Trpc3 Dagla Pde11a Arrb2 Arrb1 Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Rhob Agt Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Qrfprl Qrfpr Qrfp Hcrt Pde2a Pik3ca Shc1 Pik3r1 Pik3r2 Pik3r3 Pik3r5 Pik3cg Pdpk1 Ednrb Ednra Plxnb1 Rrh Apln Trhr Tas2r39 Oprd1 Tas2r38 C3ar1 Galr2 Galr3 Galr1 Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Htr5a Tbxa2r Gpr183 Ppbp Fpr1 Btk Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Rhoc Ppy Tas2r135 Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Tas2r4 Tas2r3 Rock2 Arhgef7 Brs3 Rock1 Tas2r7 Gabbr1 Ptger3 Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Gpr132 Edn1 Gast Edn2 Edn3 Cckbr Mtnr1b Agtr1 Agtr2 F2 Gpr37 Gpr39 Gal Penk Avp Rgr Npb Gpr143 Grp Opn1mw Kiss1r Gcgr Ccl19 Nps Ccl11 Ptafr Npw Npy Ptgdr2 Rho Mmp3 Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ccl27 Npsr1 Plcb4 Prok1 Plcb3 P2ry10 Mapk1 Pla2g4a Pdyn Plcb2 P2ry13 Plcb1 P2ry12 Ccl20 Ppp1r1b Gpr55 Gng10-ps1 Adcy3 Ccl21 Adcy4 P2ry14 Adcy1 Adcy2 Mcf2 F2rl1 Tas2r40 Camkk1 Adcy7 Fpr2l1 Tas2r41 Camkk2 Adcy8 Ppp1ca F2rl2 Adcy5 F2rl3 Adcy6 Hcar1 Ppp2cb Prokr2 Ppp2ca Adra2b Adcy9 Hcar2 Prokr1 Pde4a Cxcr1 Pde4b Cxcr2 Prkaca Cxcr3 Prkacb Prkcg Npy1r Prkcd Gpr65 Oprm1 Gpr68 Gnai2 Gnai1 Cxcr4 Prkca Cxcr5 Gnai3 Oprl1 Gna11 Camk4 Adrb2 Prkar1a Adra1b Gna14 Prkar1b Calm3 Adra1a Ppp2r5d Adra1d Gng3 Uts2 Grk2 Gnal Pomc Tacr1 Gng5 Tacr3 Gng4 Tacr2 Pde4c Anxa1 Gnaq Cxcl11 Gng7 Hebp1 Pde4d Gng8 Gngt1 Cxcl12 Casr Gnat3 Prkar2a Cxcl10 Prkar2b F2r Ppp2r1b Ppp2r1a C5ar1 Ffar3 Cdk5 Pde1b Aplnr Bdkrb2 Pde1c Ffar1 Gnb2 Bdkrb1 Gnb1 Ffar2 Pde1a Nts Gnb4 Kng1 Gnb3 Gnb5 Chrm1 Gng11 Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Tac3 Tac1 Drd3 Drd4 Opn4 Opn3 Pmch Gper1 Oxgr1 Adra2a Opn5 Sucnr1 Pyy Adora1 Adra2c Adora3 Rln3 Ltb4r2 Cxcl16 Cxcl13 Tas2r119 Opn1sw Oxt Trh P2ry2 Npy5r Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Ffar4 Grm8 Htr2a Ghrl Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Psap Htr1d Htr1f Tas2r120 Xcl1 Htr1b Kiss1 Ccl9 P2ry6 Cxcl9 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Cck Cnr1 Cnr2 Uts2r Sst Oprk1 Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Rgs9 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Gnat1 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Rgs20 Rgs17 Rgs16 Gnaz Cdc42 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction Tmod3 Tnni3 Tmod1 Tmod4 Tmod2 Tnni2 Tnni1 Tpm4 Myl4 Tpm2 Myl1 Myl2 Tpm1 Myl3 Neb Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Dmd Myh3 Actn3 Myh6 Tcap Des Mybpc2 Mybpc3 Actn2 Vim SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 96%10225159 Signaling by Erythropoietin Pik3r5 Pik3cg Irs2 Pik3ca Epor Jak2 Shc1 Lyn Crkl Rapgef1 Pik3r1 Pik3cb Grb2 Vav1 Pik3cd Epo Gab1 APOPTOTIC EXECUTION PHASE%REACTOME%R-RNO-75153.1 Apoptotic execution phase Ocln Casp7 Ctnnb1 Prkcq Prkcd Birc2 Plec Bcap31 Gsn Casp6 Satb1 Gas2 Sh3glb2 Add1 Rock1 Tjp2 Ptk2 Stk26 Sptan1 Stk24 Dnm1l Lmnb1 Acin1 Vim Apc Mapt Tjp1 Dsg3 Cdh1 Dsp Casp3 Dsg1 Dsg2 Kpnb1 Hmgb1-ps34 Kpna1 Clspn Casp8 Pkp1 Hmgb1l2 Hmgb1l1 H1-1 Lmna H1-0 Bmx H1-5 H1-4 H4f3 Hmgb2 Fnta Dffa Dffb BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 96%10225233 Biosynthesis of DHA-derived sulfido conjugates Gstm4 Ltc4s FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225339 Formation of WDR5-containing histone-modifying complexes Paxip1 Kat14 Phf20 Mbip Hcfc1 Kmt2d Hcfc2 Dr1 Kansl3 Kmt2a Kansl1 Kmt2b Kansl2 Kmt2c Phf20l1 Bod1l1 Pagr1 Men1 Tada3 Tada2a Mcrs1 Zzz3 Sgf29 Psip1 Ogt Wdr5 Ash2l Kat2a Tasp1 Akap8l Setd1b Cxxc1 Setd1a Kat8 Kat2b Yeats2 Rbbp5 Wdr82 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME%R-RNO-2995383.1 Initiation of Nuclear Envelope (NE) Reformation Ccnb1 Ppp2r2a Ppp2ca Vrk2 Ppp2r1a Vrk1 Cdk1 Emd Lmna Sirt2 Lmnb1 Ccnb2-ps2 Lbr Banf1 Ccnb2 Ankle2 Kpnb1 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-RNO-5655862.1 Translesion synthesis by POLK Rev1 Rev3l Rfc5 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Rps27a Rpa1 Rpa2 Polk Ubb Rpa3 Ubc Mad2l2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-RNO-9764560.1 Regulation of CDH1 Gene Transcription Suz12 Hist1h2ai Eed Dnttip1 Rbbp4 Rbbp7 H2ac18 Ctbp2 Zeb1 Tle1 Hist1h2bq Hdac1 Mphosph8 Hdac2 H2aj H2ab2 Smarca4 Twist1 H3-3b Hist3h2ba Kmt5a H2ac4 ENSRNOG00000068602 Ctbp1 Sirt1 H2bc18 Zmym2 ENSRNOG00000066901 H2az2 H2bc4 Ezh2 Hist1h4m Kdm1a H2bc1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) Slx4 Spidr Rad51 Rad50 Rbbp8 Brca2 Brca1 Rad51ap1 Polk Polh Rps27a Blm Wrn Dna2 Mre11 Uba52 Eme2 Kat5 Eme1 Nbn Gen1 Rad51c Pole3 Rad51b Pole2 Chek1 Pole4 Rpa1 Rpa2 Bard1 Top3a Ubb Rpa3 Palb2 Ubc Firrm Pole Rfc5 Xrcc3 Pold2 Slx1b Pold1 Xrcc2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Atm Pold4 Pold3 Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-RNO-9029569.1 LXRs regulate gene expression linked to cholesterol transport and efflux Abca1 Tbl1x Ncor2 Hdac3 Nr1h3 Nr1h2 Tbl1xr1 Gps2 Ep300 Rxrb Rxra METHIONINE SALVAGE PATHWAY%REACTOME%R-RNO-1237112.1 Methionine salvage pathway Mri1 Mtap Enoph1 Adi1 INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling Jak3 Stat3 Stat1 Il21 Stat5a Stat5b METABOLISM OF PROTEINS%REACTOME%R-RNO-392499.1 Metabolism of proteins LOC120093247 Rgs7 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Fut8 Fuca1 Rpl13 Man2a1 Rpl14 Man2a2 Rpl15 Mgat2 Rpl17 Rpl18 Suclg2 Rpl19 Rpl10 Rpl11 Cs Rpl12 Rpl10a Fh Aco2 Idh3a Nop58 LOC134480579 Commd9 Rpl23a Ceacam6 Cgm4 Commd3 Rab44 Rab37 Psgb1 Rab3d Fcgr3a Psg29 Tf Hspa8 Mgat5 Mgat1 Mgat3 Manea Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Alas1 Fech Mvd Lrr1 Fbxl21 Wsb1 Ccnf Lypd6b Rtn4rl2 Gpld1 Cdc34 Lypd8 Tecta Lypd5 Lypd4 Lypd3 Negr1 Tex101 Lypd2 Lypd1 Alpl Opcml Tectb Dpm1 Dpm3 Otoa Izumo1r Ube2g2 Ly6g6d Cd52 Ube2g1 Prss21 Nrn1 Ntm Gp2 Kbtbd8 Xpnpep2 Fbxw4 Thy1 Fbxw5 Art4 Fbxw7 Art3 Gan Atrnl1 Fbxw8 Fbxw9 Lsamp Reck Sprn Plet1 Fbxw2 Psca Klhl5 Spaca4 Cntn4 Mdga1 Klhl3 Cntn3 Mdga2 Klhl2 Cntn5 Spsb2 Ly6e Ly6h Prnd Spsb1 Ly6d Prss41 Spsb4 Eloc Elob Kctd7 Kctd6 Ube2w Ube2m Ube2k Ltn1 Pdia3 Ube2b Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Lrrc41 Klhl13 B4galnt2 Klhl11 Ube2z Fbxo21 Fbxo22 Fbxo27 Msra Pcmt1 Uba6 Msrb1 Msrb3 Fbxw17 Msrb2 Klhl25 Ube2e3 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Zbtb16 Uba1 Cul2 Cul5 Cul7 Fbxo41 Fbxo44 Oxsm Htra2 Aldh2 Lonp1 Aldh1b1 Klhl41 Clpp Iars2 Fbxo40 Clpx Btbd1 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Ube2r2 Fbxo4 Fbxo6 Fbxo7 Fbxo9 Vhl Fbxl15 Fbxl16 Fbxl19 Pdcl Cct6b Asb9 Asb7 Asb6 Dhdds Nudt14 Asb5 Alg5 Asb4 Dolpp1 Fuom Rchy1 Gmds Dolk Asb1 Fcsk Dhrsx Nus1 Fpgt Gfus Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Ube2t Otulin Dhps Eif5a Fn3k Fn3krp Eif5a2 Dohh Notum Alg9 Alg8 Alg6 Alg3 Alg2 Alg13 Alg14 Alg12 Mpdu1 Dpagt1 Amfr Engase Ngly1 Ktn1 Star Psmg1 Psmg4 Psmg3 Psma4 Psmd10 Ccna1 Pomp Psma3 Psmd5 Psmd4 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Dtl Psmd11 Ube2c Psmd14 Psmd13 Mta1 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Psmb1 Psmb3 Psmb2 Uba52 Nub1 Neurl2 Ube2d1 Commd8 Fem1b Fem1a Btrc Tulp4 Psma7 Fem1c Dcaf8 Dcaf4 Aurkb Dcaf5 Psmc5 Dcaf6 Psmc2 Dcaf7 Ccdc22 Psmc1 Psmc4 Obsl1 Psmc3 Dda1 Ccdc8 Commd4 Commd5 Commd6 Commd7 Commd2 Spsb3 Ubb Ankrd9 Socs2 Ubc Commd10 Socs6 Ube2e1 Psmb6l1 Ubd Wdtc1 Npm1 Psmd7 Dcun1d5 Dcun1d4 Psmd6 Dcun1d3 Psmd8 Cish Dcun1d2 Psmd2 Dcun1d1 Cul9 Psmd1 Dcaf17 Adrm1 Dcaf10 Dcaf11 Cul1 Cdk1 Epas1 Hif3a Prkaca Rab2b Rab34 Rab20 Igfbp3 Ptp4a2 Rab23 Rab26 Rab25 Calm3 Rab29 Rab40b Rab15 Rab17 Rab19 Pomc Rab3c Rab3b Mettl22 Etfbkmt Kin Mettl21a Eef2kmt Eef1akmt2 Eef1akmt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Muc15 Muc13 Muc19 Umod Muc5b Muc4 Asgr2 Muc6 Asgr1 Slc34a1 Adra2a Adora2b Adgrf5 Adora2a Adra2c Ctsh Slc34a2 Dmbt1 Sftpa1 Ttf1 Lmcd1 Sftpb Napsa Sftpd Sftpc Ccdc59 Abca3 P2ry2 Gata6 Zdhhc2 Ckap4 Tp53 Skic8 Polb Parp1 H2ac4 Actl6a Gata3 Ring1 ENSRNOG00000066901 Phc2 Phc1 Cbx4 Ttll6 Ttll7 Cbx2 Ttll4 Esr1 Phc3 Ttll5 Ttll10 Ttll2 Ttll3 Ttll11 Ttll12 Ttll8 Ttll13 Ttll9 H2ac18 Sin3a Csnk2a2 Csnk2a1 Bmi1 Hist1h2bq Hdac1 Wdr5 Csnk2b Ep300 Rnf2 ENSRNOG00000068602 Kat2b Rbbp5 H2bc4 Hist1h4m H2bc1 Pml Hist1h2ai St8sia6 Etf1 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 St3gal6 St6galnac2 St3gal4 St3gal5 St3gal2 St3gal3 Slc35a1 St3gal1 Nanp St6gal1 Glb1 St6gal2 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne Rbx1 Vcp Hnrnpc Hnrnpk Cops5 Hbs1l Cul3 B3gnt3 Suz12 Rbbp7 Tfam Spta1 Sptb Sptbn1 Sptbn2 Sptan1 Sptbn5 Sptbn4 App Nagk Traf6 Gnpnat1 Amdhd2 Ikbkg Uap1 Gfpt1 Gfpt2 Map3k7 Pgm3 Ube2n Renbp Nfkb2 Hadh Traf2 Fbxw11 Rela Tnip2 Nod2 Nod1 Ripk2 Nfkbia Usp14 Usp18 Tab1 Cetn2 Furin Ltbp1 Bmp4 Fbn1 Rab11b Rab11a Rab31 Rab35 Rab38 Rab1b Trappc2l Rab5a Rab4a Trappc10 Rab33b Rab33a Rab3a Chm Rab7a Rab7b Rab27a Rab39a Rab27b Trappc6b Trappc6a Trappc9 Trappc5 Trappc4 Trappc3 F7 F9 Trappc2 Trappc1 Gas6 Rab6b Rab6a Ceacam1 Rab5c Ahsg Rab5b Spp2 F10 Rab21 Chml Rab9a Rab9b Rab1A Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Qsox1 Serpina10 Rhoa Gria1 Serpind1 Arrb2 Arrb1 Tgfbr1 Lhb Cga Pros1 Serpinc1 Cd109 Thbs1 Igf2 Igf1 Pcna Atp6ap2 Ctsd Ace Mme Ctsg Gzmf Agt Ren1 Ace2 Enpep Ctsz Cma1 Ces1d Cpb1 Cpb2 Cpa3 Scg3 Psme2 Psme1 Psmb9 Proc Psmb10 Psmb8 Proz Aplp2 Mmrn1 Chgb ENSRNOG00000067174 Pdia6 Ccn1 Amelx Pappa Lgals1 Csf1 Scg2 Apoa5 Meltf Mxra8 Fam20a LOC120093819 Fam20c Klk6 Eif2b3 Fuca2 Eif2b2 Stc2 Eif2s3 Wfs1 Eif2b5 Apol7al1 Eif2b4 Hrc Pcsk9 Eif2s2 Ngfg Eif2b1 Ambn Eif2s1 Mepe Cp Pappa2 Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Igfbp7 Igfbp6 Igfals Mfge8 Matn3 ENSRNOG00000066972 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tmem132a Afp Pnpla2 Mbtps1 Igfbp2 Nup93 Igfbp5 Nup50 Igfbp4 Golm1 Igfbp1 Amtn Nup35 Mgat4a Nup54 Nucb1 Nup98 Sparcl1 Msln Cst3 Itih2 Nup58 Apol9a Klk13 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Ctr9 Paf1 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 Tpst1 Nup133 Nup210 Tpst2 Nup155 Nup153 Shmt2 Alb Mrtfa Apoa1 Apoa2 Sar1b Gps1 Apoe P4hb Apob Cops4 Cops2 Ndufs3 Rnf20 Cct6a Senp1 C3 Cct7 Fshb F2 Penk Grp Bst1 Vnn1 Pccb Nadk2 Gcg Cd55 Folr2 Gh1 Adrb2 Senp5 Senp5l1 Sumo2 Senp2 Ffar1 Kng1 Bcl10 Bche Ero1b Mboat4 Ffar4 Ghrl Inha Pla2g7 Slc30a5 Slc30a8 Pcsk1 Lep Inhba Inhbb Gip Inhbc Inhbe Nr1i2 Smc6 Smc5 Smc3 Pias3 Ddx17 Sp140 Pias1 Pias2 Nsmce4a Casp8ap2 Hic1 Eid3 Uhrf2 Nr3c2 Nr3c1 Nsmce1 Nsmce2 Xpc Zfp131 Sp3 Vdr Stag2 Stag1 Dnmt1 L3mbtl2 Daxx Safb Mageb10 Sp100 Ing2 Ppara Top2b Top2a Top1 Trim28 Trim27 Pcgf2 Thrb Thra Mbd1 Satb2 Satb1 Park7 Smc1a Nr5a1 Tshb Nfe2l2 Taf9b Taf10 Mdh2 Ddb1 Cul4a Cul4b Mat2b Qtgal Adamts1 Adamts3 Adamts2 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Pofut3 Pofut4 Thsd4 Cfp Spon2 Icmt Spon1 Sspo B3glct B3gnt9 B3gnt8 Fn1 B3gnt6 B3gnt5 Galnt1 Galnt2 Rce1 Galnt5 ENSRNOG00000067432 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5a Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Tgfa Adamts19 Fgf23 Adamts10 Sbspon Areg Kbtbd7 A4gnt Adamts12 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Adamts20 Thsd7b Il6 Fga Fgg Mt-atp6 Atp5f1c Atp5pd Atp5pf Atp5mg Atp5f1b Atp5f1a Atp5po Mt-atp8 Cdc25a Rpa1 Slc35c1 Eif4ebp1 Rraga Rps6 Eif4e Apeh Blm Pias4 Slc25a5 Ube2i Ube2v2 Bard1 Prkdc Clspn Xrcc4 Bap1 Tp53bp1 Brcc3 Herc2 Rnf168 Sumo1 ABRAXAS1 Sumo3 Rad52 Babam1 Babam2 Ubxn1 Brca1 Uimc1 Riox2 Mitf Jmjd6 Rps27 Dync1h1 Cdca8 Incenp Dync1i2 Dync1i1 Glud1 Acadsb Rangap1 Arg2 Dync1li2 Dync1li1 Dynll1 Dynll2 Cop1 Mdm4 Hsd17b10 Acat1 Birc5 Aldh18a1 Acad8 Men1 Tnks2 Axin1 Axin2 Cdc73 Rnf146 Ctbp1 Tnks Usp34 Smurf2 Leo1 Apc Nlrp3 Txn Rig1 Ikbke Cyld B3gnt7 B3gnt2 Idh2 B4galt4 B4galt5 B4galt6 B4gat1 B4galt2 B4galt3 Mief1 Mtrf1l Trip4 Eif5 Mt-cyb Pelo Gfm1 Gfm2 Srp68 Mrrf Srp9 Mrps9 Mrps2 Mrps7 Mrps5 Mt-nd4l Tcf25 Srp54 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Nrip1 Mrpl45 Mrpl46 Mrpl48 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Pdk1 Mrps27 Nr1h3 Malsu1 Nr1h2 Mrpl51 Pdhb Mrpl32 Mrpl33 Oxa1l Rxra Mrpl34 Mrpl35 Mrpl36 Sphk1 Mrpl37 Pgr Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Srp14 ENSRNOG00000068816 Eral1 Srp19 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Rara Mrpl16 Mrpl17 Mrpl18 Mmp2 Ascc3 Ascc2 Mrpl19 Eif5b Nemf Zfp598 Gadd45gip1 Mt-co3 Dld Mt-co2 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Klhdc10 Ptcd3 Yy1 Mt-co1 Mt-nd5 Dlat Mt-nd4 Nr5a2 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 Ins1 Lman1 Scfd1 Actr1a Lman2 Ins2 Ggcx Sec22a Bglap Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Tmem115 Kdelr2 Kdelr3 Sec23ip Sec16b Sec16a Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Ppp6c Sec31b Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 AC132020.1 Ogdh Dlst Kgd4 Hsp90b1 Socs5 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Fktn Pomgnt1 Actg1 Rabggta Rabggtb Socs3 Cox5a Cox5b Ech1 Ube2d3 Ube2d2 Ide Hspd1 Acot1 Acot2 Pex2 Acot5 Acot3 Ldhd Usp9x Pex5 Pex14 Pex13 Pex12 Pex10 Kat2a Hdac2 Me2 Hdac4 Alpi Nr1h4 C4b Rab36 C4 Cops3 Cops6 Cops8 Gcsh Lipt1 Lipt2 Nfu1 Ndufab1 Fdx1 Dbt Lias Cops7a Cops7b Tnc Dmp1 Vcan Akp3 Alpp Alpg Galnt3 Rab43 Ttgn1 Ppa1 Ppa2 Dph5 Dph6 Eef2 H2ac25 Prmt3 Rps2 Calr Arsa Sts Arsl Arsk Arsj Arsi Arsg Sumf1 Arsb Sumf2 Cdh2 Hspa9 Sec11c Sec11a Prkcsh Rab4b Afg3l2 Cand1 Pomt1 Pheta2 Pomt2 Birc2 Pmpca Megf11 Canx Spcs3 Spcs1 Spcs2 Pigs Pigu Pigt Gpaa1 Pigk Plaur Pgap1 Hcfc1 Tada3 Mcrs1 Ogt Traf3 Spg7 Srd5a3 Twnk Pign Pigq Pigp Pigw Ssbp1 Pigv Pigx Pigc Pigb Dpm2 Piga Pigm Pigl Pigg Pigf Dpp4 Gpr119 Pigh Gmppa Pmm2 Prkn Mpi Pmm1 Ripk1 Nploc4 Ube2l3 Sdc2 Gpihbp1 Gpc3 Mgat5b B3galnt2 Pomk Pomgnt2 Adam10 ENSRNOG00000069479 Adamts5 Adamts4 Plg Spp1 Uba2 Rwdd2b Sae1 Timp1 Mmp1b Eef1d Eef1b2 Eef1g Eef1a1 Rps14 Rps15 Rps16 Rps17 Rps15a Rps18 Rps19 Pabpc1 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Stambpl1 Nfrkb Myc Foxk2 Foxk1 Vdac2 Yod1 Vdac3 Vdac1 Tfpt Becn1 Tomm70 Otud7a Actr5 Otud7b Actr8 Josd2 Josd1 Rnf123 Rnf128 Stam Snx3 Ar Hif1a Zranb1 Cftr Siah2 Keap1 Ino80 Wdr48 Ddb2 Ufd1 Foxo4 Uchl3 Abraxas2 Uchl5 Ifih1 Fkbp8 Ino80e Ino80d Rnf181 Ino80c Shprh Ino80b Rad18 Il33 Wdr20 Rnf152 Rnf40 Mbd5 Mbd6 Rnf144a Uchl1 Hltf Wac Nedd8 Atxn3 Atxn7 Suds3 Usp2 Mul1 Usp3 Usp4 Kdm1b Usp5 Usp7 Usp8 Hgs Ruvbl1 Stambp Rad23a Rad23b Tomm20 Bdh1 Tada2b Smad1 Oxct1 Smad2 Hmgcs2 Smad3 Smad4 Smad7 Otub1 Usp44 Usp42 Usp48 Usp47 Stam2 Usp30 Otub2 Vcpip1 Usp33 Usp37 Mysm1 Tnip3 Tnip1 Senp8 Otud3 Usp22 Uqcrq Usp21 Usp20 Usp26 Ndufv1 Usp25 Ndufv3 Usp24 Usp29 Usp28 Ccp110 Asxl1 Asxl2 Pten Usp12 Ndufs1 Usp11 Usp10 Ndufa13 Usp16 Usp15 Usp13 Usp19 Eci1 Uqcrc2 Etfb Rab2a Cct3 Cct2 Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Tcp1 Cct8 Cct5 Cct4 Tfap2c Tdg Rpl4 Rpl5 Rpl3 Rgs9 Rpl35 Rpl36 Rpl37 Rpl38 Rpl39 Camkmt Rpl8 Rpl9 Rpl6 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Ubxn7 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 LOC100910714 Dcaf13 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-RNO-1855167.1 Synthesis of pyrophosphates in the cytosol Ippk Itpk1 Nudt4 Ip6k1 Nudt3 Ip6k3 Ppip5k1 Ppip5k2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223651 Amine ligand-binding receptors Drd3 Drd4 Drd5 Taar6 Adra2b Taar9 Taar3 Taar2 Adra2a Taar5 Taar1 Adra2c Gpr143 Adrb2 Htr4 Adrb1 Adra1b Adrb3 Adra1a Htr6 Adra1d Htr7 Taar8c Htr2a Htr2c Htr2b Htr5a Htr1d Htr1f Chrm1 Hrh1 Chrm3 Chrm2 Htr1b Chrm5 Htr1a Hrh4 Chrm4 Hrh2 Hrh3 Drd2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%10223693 Glutamate binding, activation of AMPA receptors and synaptic plasticity Tspan7 Grip1 Prkcg Prkca Nsf Ap2m1 Myo6 Cacng8 Cacng3 Grip2 Cacng4 Prkcb Epb41l1 Cacng2 Ap2s1 Gria4 Gria3 Camk2g Camk2d Ap2a2 Gria2 Ap2a1 Camk2b Ap2b1 Pick1 Dlg1 Gria1 Dlg4 Camk2a Akap5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222227 SOS-mediated signalling Grb2 Irs2 Sos1 Irs1 MAPK1 (ERK2) ACTIVATION%REACTOME%R-RNO-112411.1 MAPK1 (ERK2) activation Mapk1 Jak2 Tyk2 Ptpn11 Il6 Map2k2 Il6st Il6r PEROXISOMAL PROTEIN IMPORT%REACTOME%R-RNO-9033241.1 Peroxisomal protein import Phyh Amacr Eci2 Mpv17 Gstk1 Hacl1 Pex26 Mlycd Scp2 Gnpat Crat Acox1 Acox2 Ech1 Ehhadh Acox3 Ube2d3 Ube2d2 Pipox Acaa1b Tysnd1 Hsd17b4 Lonp2 Hao1 Hao2 Pecr Dao Dhrs4 Slc27a2 Ide Decr2 Crot Nudt19 Rps27a Acot1 Acot2 Pex2 Pex1 Acot5 Acot3 Acot4 Pex7 Usp9x Acot8 Pex6 Pex5 Cat Uba52 Baat Ddo Ube2d1 Zfand6 Agps Agxt Nudt7 Hmgcl Nos2 Ephx2 Pex14 Pex13 Pex12 Pex10 Ubb Ubc Idh1 RUNX3 REGULATES P14-ARF%REACTOME%R-RNO-8951936.1 RUNX3 regulates p14-ARF Runx3 Cbfb Ccnd1 Hdac4 Ep300 Tgfb1 RELAXIN RECEPTORS%REACTOME%R-RNO-444821.1 Relaxin receptors Rln1 Rxfp3 Rxfp1 Insl3 Rln3 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 96%10225071 MET activates RAP1 and RAC1 Hgf Grb2 Rap1a Rap1b Dock7 Rac1 Met Crkl Crk Rapgef1 Gab1 SIGNALING BY PDGF%REACTOME%R-RNO-186797.1 Signaling by PDGF Stat6 Grb7 Thbs4 Stat3 Ptpn12 Furin Stat1 Plcg1 Thbs2 Nck1 Plg Spp1 Rasa1 Plat Pdgfa Pdgfb Thbs1 Stat5a Stat5b Bcar1 Pik3ca Col4a1 Nck2 Col4a2 Crkl Pdgfrb Src Pdgfra Rapgef1 Pik3r1 Pik3cb Nras Grb2 Pik3r2 Kras Sos1 Hras Pdgfc Ptpn11 Pdgfd Crk SIGNALING BY ALK%REACTOME%R-RNO-201556.1 Signaling by ALK Ptprz1 Pik3ca Hdac2 Shc1 Stat3 Ptpn6 Alkal2 Plcg1 Alkal1 Ep300 Pik3r1 Pik3cb Jak3 Pik3r2 Irs1 Hdac3 Alk Mdk Hdac1 Ptn SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 96%10224441 SHC-related events triggered by IGF1R Igf1 Grb2 Shc1 Sos1 Igf1r Igf2 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%10225065 Vitamin E transport Ttpa SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 96%10224347 Signaling by NOTCH Aph1b Uba52 Jag2 Dll1 Dll4 Tmed2 Dtx4 Egf Ubb Ubc Ybx1 Egfr Jag1 Prkci Elf3 Notch3 Akt1 Itch Rps27a Adam10 Notch4 Wwp2 Psenen Psen1 Psen2 Ncstn Dtx2 Aph1a Ywhaz TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-RNO-5656169.1 Termination of translesion DNA synthesis Uba52 Usp10 Pole3 Pole2 Ube2l6 Pole4 Rpa1 Rpa2 Polk Trim25 Ubb Rpa3 Ubc Polh Rev1 Poli Pole Rfc5 Pold2 Pold1 Isg15 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pclaf Pold3 Usp43 Rps27a Uba7 DISINHIBITION OF SNARE FORMATION%REACTOME%R-RNO-114516.1 Disinhibition of SNARE formation Prkcb Stxbp3 Prkcg Stx4 Prkca CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-RNO-6807047.1 Cholesterol biosynthesis via desmosterol (Bloch pathway) Ebp Msmo1 Sc5d Lbr Nsdhl Dhcr24 Dhcr7 Tm7sf2 Hsd17b7 DNA REPLICATION INITIATION%REACTOME%R-RNO-68952.1 DNA replication initiation Prim2 Prim1 Pole Pole3 Pole2 Pole4 Pola2 Pola1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-RNO-3270619.1 IRF3-mediated induction of type I IFN Sting1 Nlrp4 Dtx4 Tbk1 Irf3 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224265 Mitochondrial biogenesis Sirt5 Sirt3 Glud1 Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Cycsl2 Atp5mf Gabpa Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Idh2 Acss2 Cycs Sod2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins Qtgal B3gnt9 B3gnt8 B3gnt6 B3gnt5 Galnt1 Galnt2 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Gcnt1 C1galt1 C1galt1c1 Galntl6 Galntl5 Muc15 Muc13 Muc19 A4gnt Muc5b Muc4 Muc6 Galnt9 St6galnac3 St6galnac2 St3gal4 St3gal2 St3gal3 St3gal1 St6gal1 B3gnt7 B3gnt2 B4galt5 B4galt6 B3gnt3 Galnt3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222295 Glycerophospholipid biosynthesis Plaat5 Agk Ddhd2 Agpat4 Agpat1 Pcyt2 Tafazzin Cept1 Lclat1 Etnk2 Etnk1 Etnppl Chka Gnpat Chkb Selenoi Phospho1 Lpin3 Lpin2 Plb1 Chat Dgat2l6 Dgat2 Dgat1 Pnpla3 Pld1 Stard7 Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Hadha Hadhb Agpat2 Alpi Cpne1 Pla2g4f Pla2g2d Cpne3 Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Csnk2a2 Pla2g4d Plbd1 Pla2r1 Csnk2a1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pld2 Pla2g5 Csnk2b Ptdss1 Ptdss2 Pla2g15 Pla2g4b Agpat3 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Pctp Awat2 Pnpla2 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pla2g6 Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Stard10 Gpd1l Abhd4 Osbpl10 Miga2 Miga1 Gpat2 Gpd1 Pgp Mboat1 Mboat2 Pitpnb Gpam Gpd2 Osbpl5 Pld6 Pla1a Mgll Osbpl8 Pla2g4a Cpne6 Cpne7 Liph Lipi Cds2 Acp6 Gpat4 Gpat3 Lpcat3 Lpcat2 Tmem86b Pnpla8 Plaat1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%10224101 ER Quality Control Compartment (ERQC) Rps27a Uba52 Ubb Ubc POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%10224517 Postmitotic nuclear pore complex (NPC) reformation Nup133 Nup155 Rangap1 Nup37 Ube2i Rcc1 Pom121 Nup205 Nup107 Sec13 Nup188 Nup160 Ahctf1 Ndc1 Nup85 Nup93 Nup43 Ran Nup35 Sumo1 Nup98 NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway Ikbkg Casp1 Casp8 Map3k7 Ube2n Mapk14 Birc2 Cyld Itch Mapk12 Tab3 Tab2 Aamp Mapk13 Tab1 Casp2 Nod2 Casp9 Nod1 Mapk11 Map2k6 Traf6 Ripk2 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway Map2k1 Mapk1 Raf1 Braf Mapk3 Map2k2 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 96%10224611 SUMOylation of DNA methylation proteins Ube2i Dnmt1 Sumo1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-RNO-75953.1 RNA Polymerase II Transcription Initiation Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-RNO-418592.1 ADP signalling through P2Y purinoceptor 1 Gna11 Pla2g4a Gna14 P2ry1 Mapk14 Src Gnaq DNA REPAIR%REACTOME DATABASE ID RELEASE 96%10222001 DNA Repair Chd1l Ppie Usp45 Ube2t Gps1 Nploc4 Sprtn Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Mapk8 Polr2i Polr2j Ube2n Gtf2h2 Gtf2h1 Mlh1 Msh6 Msh2 Gtf2h3 Pms2 Gtf2h5 Cops4 Ercc2 Cops2 Ercc3 Ppp5c Cetn2 Tcea1 Terf2 Neil3 Acd Terf1 Mpg Ogg1 Terf2ip Mutyh Tinf2 Pot1 Ccna1 Ccna2 Cops3 Cops6 Pclaf Cops8 Usp43 Rps27a Usp1 Dtl Ercc6 Fancl Fancm Uba52 Fanca Fancb Fancc Fance Fancf Fancg Neil2 Pnkp Neil1 Pole3 Cops7a Pole2 Cops7b Pole4 Rpa1 Rpa2 Uvssa Trim25 Rpa3 Ubb Ubc Faap100 Pole Faap24 Nfrkb Isg15 Faap20 Cdk2 Tfpt Actr5 Yy1 Actr8 Ino80 Wdr48 Ddb2 Ufd1 Alkbh5 Fto Ino80e Ino80d Ino80c Ino80b Rad18 Ube2l6 Usp7 Rnf111 Mad2l2 Rev1 Rev3l Ruvbl1 Poli Rad23a Rad23b Sumo2 Blm Wrn Dna2 Rif1 Ppp4r2 Paxip1 Pias4 Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Usp10 Gen1 Hus1 Atrip Lig3 Lig4 Sirt6 Rad51c Baz1b Rad51b Chek1 Chek2 Znf830 Ube2v2 Ube2b Rad9a Rad9b Bard1 Top3a Prkdc Palb2 Firrm Tp53 Ppp4c Nhej1 Lig1 Parg Clspn Rad17 Polb Fen1 Kpna2 Parp2 Xrcc6 Parp1 Xrcc3 Rfc5 Apex1 Slx1b Pold2 Adprs Xrcc2 Pold1 Tdp2 H2ab2 Rfc3 Xrcc5 Rfc4 Tdp1 Pcna Xrcc4 Rfc1 Xrcc1 Ccnh Atm Rfc2 Atr H2ac4 Bap1 Pold4 Tp53bp1 Pold3 Actl6a Apbb1 Kdm4b Kdm4a Exo1 Pias3 Mus81 Rmi2 Fignl1 Rmi1 Pias1 Brip1 Brcc3 Abl1 ENSRNOG00000066901 Smarca5 Uba7 Polq Herc2 Rnf168 Sumo1 ABRAXAS1 Polm Sumo3 Xpc Xab2 Rnf8 Dclre1c Rhno1 Slx4 Nsd2 Spidr Rad51 Cdk7 Rad50 Rad52 Eya2 Eya1 Ercc1 H2ac18 Eya4 Ercc4 Babam1 Eya3 Babam2 Topbp1 Rbbp8 Ubxn1 Brca2 Mnat1 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Prpf19 Actg1 Poll Rad1 Polh H2aj Hist3h2ba ENSRNOG00000068602 Dclre1a Isy1 Dclre1b Mbd4 Fanci Smug1 Nthl1 Fancd2 Haus3 Tdg Ung Fan1 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Rchy1 Mcrs1 Aqr Rbx1 Vcp Cops5 Xpa Ddb1 Cul4a Cul4b WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%10224619 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cltb Cltc Fzd2 Fzd5 Wnt5a Ap2s1 Ap2a2 Ap2a1 Ap2b1 Ror1 Ap2m1 Ror2 Clta RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-RNO-110314.1 Recognition of DNA damage by PCNA-containing replication complex Wdr48 Uba52 Rad18 Pole3 Pole2 Pole4 Ube2b Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Pold4 Pold3 Rps27a Usp1 Dtl Ddb1 Cul4a Cul4b CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited Ripk1 Tnfsf10 Casp8 Fas Fadd Faslg Traf2 Tradd Cflar ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224081 Antigen processing: Ubiquitination & Proteasome degradation Mib2 Ube2d3 Ube2d2 Prkn Stub1 Ube2l3 Kbtbd7 Smurf2 Ube2n Fbxw11 Cbll1 Ube2j2 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdc16 Rnf123 Siah2 Keap1 Lrr1 Nedd4 Rnf220 Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 Dcaf1 Rnf126 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Rnf111 Siah1 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 Rnf130 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Klhl2 Ube4a Spsb2 Trim9 Spsb1 Trip12 Wwp1 Spsb4 Lrsam1 Eloc Huwe1 Elob Ube2j1 Kctd7 Ube2u Kctd6 Ube2w Ube2m Ube2k Rnf182 Ube2o Ltn1 Ube2v2 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Rnf41 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Herc2 Socs1 Trim71 Klhl25 Rnf19b Ube2e3 Ube2e2 Klhl21 Btbd6 Hace1 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Cul2 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Itch Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 Rchy1 Asb1 Lnx1 Rbx1 Socs3 Smurf1 Cul3 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%10224623 PINK1-PRKN Mediated Mitophagy Map1lc3b Ube2n Uba52 Ube2d3 Ube2d2 Ubb Ubc Mfn1 Mfn2 Tomm22 Tomm20 Atg5 Tbk1 Atg12 Vdac2 Atg9a Sqstm1 Vdac3 Vdac1 Tomm40 Prkn Optn Tomm70 Rps27a Mterf3 Map1lc3a Pink1 Ube2l3 Tomm7 B CELL ACTIVATION%REACTOME%R-RNO-983705.1 B Cell Activation Rasgrp1 Calm3 Itpr3 Itpr2 Itpr1 Lyn Nras Grb2 Kras Sos1 Hras Ikbkb Ikbkg Dapp1 Cd22 Blnk Cd79a Cd79b Nfkb1 Fbxw11 Rela Ppp3ca Ppp3cb Trpc1 Nfatc1 Stim1 Nfatc3 Malt1 Nfatc2 Bcl10 Ppp3r1 Nfkbie Rel Nfkbib Prkcb Nfkbia Btk Chuk Ptpn6 Psma4 Psma3 Psma6 Pik3r1 Psma5 Psma2 Psma1 Cd19 Rps27a Psmd12 Psmd11 Vav1 Pik3cd Psmd14 Psmd13 Sh3kbp1 ENSRNOG00000069193 AABR07065813.1 Skp1 ENSRNOG00000062915 Igll1 Psmb5 ENSRNOG00000065191 Psmb4 Ighl12 Psmb7 ENSRNOG00000062682 Psmb6 ENSRNOG00000070812 ENSRNOG00000070415 Psmb1 ENSRNOG00000070810 Psmb3 ENSRNOG00000066926 Psmb2 ENSRNOG00000066406 Uba52 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Syk Btrc Iglc1 Nck1 ENSRNOG00000070159 Psma7 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Psmc5 Psmc2 ENSRNOG00000066971 Psmc1 ENSRNOG00000063341 Psmc4 ENSRNOG00000065283 Psmc3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Ubb ENSRNOG00000067679 ENSRNOG00000070832 Ubc ENSRNOG00000064041 ENSRNOG00000064481 Psmb6l1 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Psmd7 ENSRNOG00000063713 ENSRNOG00000062820 Psmd6 ENSRNOG00000064886 Psmd8 Fkbp1a ENSRNOG00000064490 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 Psmd1 ENSRNOG00000067603 Adrm1 Cul1 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%10224385 alpha-linolenic acid (ALA) metabolism Fads1 Elovl2 Elovl3 Abcd1 Elovl5 Elovl1 Scp2 Acox1 Acsl1 Acaa1b Hsd17b4 Acot8 Fads2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-RNO-212165.1 Epigenetic regulation of gene expression Suz12 Eed Gsk3b Rbbp4 Znf431l2 Rbbp7 Tasor Men1 ENSRNOG00000065205 Znf624l Phf19 Zfp867 Mtf2 Epop Cdk5 Rex2l4 Zfp52 Zfp950l5 Mybbp1a Znf354a Dnmt3a Polr2h LOC102546572 Polr2e Polr2f Paxip1 Ddx21 Baz1b Polr1c Znf382 Suv39h1 Kat2a Rrp8 Ezhip H2ab2 Zfp317 H2ac4 Sirt1 Setd1b Setd1a Morc2 Abl1 ENSRNOG00000066901 Smarca5 Sf3b1 Ncoa2 Kmt2d Crebbp Dnmt1 Dek Kmt2a Kmt2b Kmt2c H2ac18 Zfp324 LOC120095871 Setdb1 Trim28 Zfp719 Actg1 Hist1h2bq Wdr5 Ash2l ENSRNOG00000070049 Mphosph8 Aebp2 Ezh1 H2aj Atf7ip Zfp758 Polr1b Tbp H3-3b Polr1a Polr1f Hist3h2ba Polr1g Ep300 Polr1e Polr1h ENSRNOG00000068602 Med23 Taf1d Med24 Med20 Mbd2 Zfp964 Tasp1 Taf1a Akap8l Taf1c Tdg Cxxc1 Taf1b Kat8 H2bc18 Med27 Med12 Kat2b Med1 H2az2 Yeats2 Rbbp5 Med13 H2bc4 Ercc6 Med14 Hist1h4m Wdr82 Jarid2 H2bc1 Rxra Med10 Ccnc Med4 Hist1h2ai Pparg Med6 Kat14 Phf20 Mbip Hcfc1 Tbl1x Med16 Med17 Hcfc2 Dr1 Cbx5 Kansl3 Kansl1 Kansl2 Phf20l1 Ajuba Bod1l1 Pagr1 Tada3 Med30 Pphln1 Tada2a Med31 Myo1c Ppargc1a Ppargc1b Mcrs1 Zzz3 Hdac3 Sgf29 Psip1 Ogt Tbl1xr1 Rb1 Zfp808l3 Ncor2 Gps2 Ncoa3 Ezh2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-RNO-198693.1 AKT phosphorylates targets in the nucleus Foxo1 Creb1 Foxo4 Rps6kb2 Foxo6 Akt3 Akt2 Akt1 Nr4a1 Foxo3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-RNO-418038.1 Nucleotide-like (purinergic) receptors P2ry4 P2ry1 Lpar6 Lpar4 Adora2b Gpr17 Adora2a Adora1 Adora3 P2ry10 P2ry13 P2ry12 P2ry14 P2ry2 P2ry6 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere Acd Terf1 Fen1 Terf2ip Pold2 Pold1 Tinf2 Pot1 Pcna Pold4 Pold3 Rpa1 Blm Rpa2 Wrn Rpa3 Terf2 Lig1 Dna2 BASE EXCISION REPAIR%REACTOME%R-RNO-73884.1 Base Excision Repair H2ac18 Hist1h2bq Terf2 Neil3 Acd Terf1 Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 Pot1 Hist3h2ba ENSRNOG00000068602 Mbd4 Smug1 Nthl1 Tdg Ung H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Lig3 Neil2 Pnkp Neil1 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 Parg Polb Fen1 Pole Parp2 Parp1 Rfc5 Pold2 Apex1 Pold1 Adprs H2ab2 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Rfc2 H2ac4 Pold4 Pold3 ENSRNOG00000066901 AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance Erbb2 Gsk3b Frs2 Prkcq Ranbp9 Tln1 Rasa1 Fgfr1 Creb1 Ret Spta1 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Sema5a Mapk3 Sptan1 Sptbn5 Artn Ptprc Rps6ka5 Gfra1 Nras Sptbn4 Grb2 Gfra2 Gfra4 Fyn Kras Sos1 Hras Sdc2 Mapk7 Arpc3 Arpc2 Map2k2 Sema4d Plxnb1 Map2k1 Arpc5 Arpc4 Dnm2 Nrp1 Efna1 Egfr Efna2 Epha1 Shc3 Epha3 Hsp90ab1 Epha4 Pspn Epha5 Epha6 Epha7 Epha10 Efna4 Dcc Gdnf Efna5 Dpysl2 Arpc1b Kif4b Actr2 Ap2s1 Arpc1a Kif4a Actr3 Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Nrtn Arhgef28 Numb Sh3gl2 Ezr Itgav Rhoc Cd72 Plxnb3 Sema6d Crmp1 Plxna4 Myo9b Plxna3 Shank3 Itga2b Plxna2 Rras Tyrobp Met Plcg1 Sema4a Dpysl3 Dpysl4 Dpysl5 Plxnc1 Arhgap35 Sema3a Sema7a Fes Trem2 Sema3e Itgb1 Plxna1 Grb10 Itgb3 Sdcbp Efnb1 Arhgef7 Rock2 Efnb2 Rock1 Efnb3 Plxnd1 Ephb1 Dscaml1 Ephb2 Ntn4 Ephb3 Dscam Ephb4 Ephb6 Unc5a Nck2 Rac1 Pak3 Rnd1 Git1 Hsp90aa1 Sh3kbp1 Limk1 Dok1 Nck1 Actb Itga9 Mmp2 Mmp9 Lypla2 Gap43 Mapk1 Grb7 Prkaca Prkacb Pdlim7 Dok4 Dok5 Prkca Dok6 Cdk5r1 Ank1 Pak1 Pak2 Cdk5 Lyn Nfasc Yes1 Src Rlc-a Rhoa Ngef Grin1 Grin2b Epha2 Reln Dab1 Rhob Rap1gap Dok2 Csnk2a2 Csnk2a1 Actg1 Csnk2b Pik3ca Tiam1 Shc1 Gab2 Farp2 Pip5k1c Pik3r1 Arhgef11 Pik3cb Arhgef12 Vav3 Pik3r2 Pik3r3 Vav2 Pik3cd Itsn1 Ptpn11 Psenen Psen1 Psen2 Kalrn Ncstn Aph1a Gab1 Aph1b Irs2 St8sia4 Vldlr Trio St8sia2 Ap2m1 Clta Cltc Dnm1 Cdc42 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes Suz12 Eed Wdr77 Rbbp4 Rbbp7 Suds3 Brpf3 Kdm1b Kdm5b Coprs H2ac25 Prmt7 Atf2 Dnmt3a Prmt3 Rps2 Brwd1 Nfkb2 Nfkb1 Rela Suv39h1 Hdac2 Arid1a Arid1b Hdac10 Kmt5a Hdac8 H2ac4 Actl6a Actl6b Kdm4b Smarce1 Kdm4a Setd1b Setd1a ENSRNOG00000066901 Ccnd1 Padi2 Ncoa2 Padi3 Padi4 Nsd2 Padi1 Kmt2d Kat7 Padi6 Ehmt1 Kdm6b Kmt2a Kdm7a Kmt2b Kmt2c Phf2 H2ac18 Phf8 Ing4 Ing5 Setdb2 Setdb1 Brd1 Pax3 Dot1l Setd3 Nsd3 Pbrm1 Setd2 Prmt6 Setd7 Hist1h2bq Setd6 Prmt1 Nsd1 Smarcb1 Ash1l Riox2 Hdac1 Suv39h2 Wdr5 Smyd2 Rcor1 Ash2l Mecom Smyd3 Brms1 Aebp2 Kmt5b Hat1 Kdm4c Atf7ip Jade1 Jade2 Smarca2 Jade3 Smarca4 Brpf1 Kat6b Kat6a Prdm16 Hist3h2ba Sap30l Kdm4d Meaf6 ENSRNOG00000068602 Arid5b Chd3 Uty Chd4 Smarcd1 Msl2 Msl3 Smarcd3 Kdm5c Msl1 Smarcd2 Kdm5a Kat8 Kdm6a Mta1 H2bc18 Arid4b Mta2 Arid4a Mta3 Jmjd6 Mbd3 Kdm2b Rbbp5 Rest H2bc4 Kdm1a Kmt5c Hist1h4m Gatad2a H2bc1 Kdm3b Gatad2b Kdm3a Prdm9 Smarcc1 Hist1h2ai Hmg20b Phf20 Hcfc1 Tbl1x Sap18 Kansl3 Kansl1 Kansl2 Mcrs1 Hdac3 Ogt Tbl1xr1 Prmt5 Ncor2 Carm1 Gps2 Cdk4 Ezh2 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity Runx3 Psmb6 Cbfb Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Src Ep300 Psma5 Psma2 Smurf1 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Tgfb1 Psmb7 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%10223735 Nitric oxide stimulates guanylate cyclase Pde5a Pde11a Itpr1 Pde10a Prkg1 Pde1b Pde9a Pde1a Nos3 Nos2 Irag1 Pde2a Nos1 Prkg2 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 96%10225295 Transcriptional regulation of granulopoiesis Cebpa Cdk4 Cdk2 Rara Rxra HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state Adcy5 Adcy6 Gsk3b Adcy9 Prkaca Prkacb Prkar1a Prkar1b Rpgrip1l Tulp3 Adcy10 Ift140 Kif3a Fuz Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Intu Prkar2a Wdr35 Prkar2b Dync2h1 Psma4 Ift172 Wdr19 Psma3 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Gpr161 Psmd8 Gli1 Psmd2 Gli3 Gli2 Psmd1 Adrm1 Kif7 Rbx1 Cul1 Smo Ptch1 Sufu Adcy3 Numb Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-RNO-170660.1 Adenylate cyclase activating pathway Adcy5 Adcy6 Adcy9 Adcy3 Adcy4 Gnal Adcy1 Adcy2 Adcy7 Adcy8 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation Mief1 Mtrf1l Mt-cyb Gfm1 Gfm2 Mrrf Mrps9 Mrps2 Mt-atp6 Mrps7 Mrps5 Mt-nd4l Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mt-atp8 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Ndufab1 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mt-co3 Mt-co2 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%10222119 Phase I - Functionalization of compounds Cyp39a1 Cyp2s1 Ncoa2 Cyp8b1 Cyp7b1 Nr1h4 Cyp2w1 Cyp46a1 Cyp27a1 Cyp2c24 Cyp7a1 Smox Aldh1a1 Cyp2u1 Pomc Arnt2 Aldh2 Arnt Ahrr Ahr Aldh1b1 Cyp11a1 Fdx2 Fdxr Adh6 Adh5 Cyp26b1 Cmbl Ephx1 Aldh3a1 Fmo1 Aadac Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Cyp11b1 Cyp11b2 Cyp19a1 Rxra Acss1 Cyp26a1 Mtarc2 Bphl Cyp24a1 Cyp3a9 Cyp27b1 Cyp1b1 Adh4 Fdx1 Cyp3a18 Adh1 Cyp4v2 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Tbxas1 Cyp3a1 Cyp1a2 Cyp2d4 Ptgis Cyp3a62 Cyp3a2 Ptgs1 Ces2h Maoa Hsp90ab1 Ptges3 Cyb5b Cyp2j16 Adh7 Cyp4f39 Cyp21 Cyp2j3 Cyp11b3 Cyp4f1 Cyp4a14 Cyp2f2 Aoc1 Maob Cyp4f3 Cyp4a12 Cyp4f40 Cyp26c1 Cyp4b1 Cyp2a2 Acss2 Cyp2a1 Cyb5r3 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 Ces1d CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222007 Carbohydrate metabolism Aldoa Nup133 Nup210 Pfkl Nup155 Pgk2 Pck1 Nup153 Pfkm Pfkp Pck2 Pgm2l1 G6pc1 Pkml1 Gck Hk2 Hk3 Adpgk G6pc3 Naglu Tpi1l2 Hpse2 Hpse Sgsh Abcc5 Sdc4 Sdc3 Sdc2 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Slc26a2 Gpc6 Slc26a1 Slc35b3 Slc35b2 Papss2 Papss1 Slc26a11 Man2b1 Sdc1 Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Gns B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Glb1l2 Fmod Galns Uxs1 Hexa Hexb Ugp2 B4gat1 Lum Omd Chst1 Chst3 Chst2 B4galt2 Man2c1 B4galt3 Acan Chst6 Ogn Cd44 Tkfc Aldh1a1 Manba Glyctk Sord Aldob Akr1b1 Khk Chp1 B3galt6 Cemip Fam20b B4galt7 Pxylp1 Chp1l1 Hyal2 Has1 Has2 Has3 Xylt1 Hs3st4 Xylt2 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Bcan Hs2st1 Ndst1 Vcan Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Ncan Hs6st2 Hs6st1 Slc2a1 Dcn Ext2 Ext1 Pgk1 Rpe Taldo1 Prps1l3 Pgd Prps1 Rpia Dera Prps2 Shpk Pgm2 Pgls Tkt Rbks Dsel Ust Dse Cspg5 Bgn Cspg4 Chst14 Chst15 Idua Hyal4 Hyal3 Ids Hyal1 Gusb Calm3 Slc9a1 Akr1a1 Arsb B3galt1 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 Abo2 Dcxr Cryl1 Xylb Hyal5 Gale Galt Galm Galk1 Ctsl Phkg1 Gaa Gbe1 Phkg2 Agl Pygl Pygm Phkb Ppp1r3c Gys1 Akr1e2 Phka1 Phka2 Gyg1 Pgm1 St6galnac6 Slc17a5 St3gal6 St3gal4 St3gal2 St3gal3 G6pdx St3gal1 Nup93 Nup50 Glb1 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Gnpda1 Nup205 Gpi Nup107 Gnpda2 Eno3 Sec13 Eno2 Eno4 Nup188 Tpr Pfkfb4 Pfkfb3 Nup160 Pfkfb2 Rae1 Pfkfb1 Pc Pgam2 Ndc1 Chst11 Pgam1 Chst12 Slc37a4 Chsy1 Tpi1 Nup85 Chsy3 Slc37a2 Nup42 Chst13 Slc37a1 Nup62 Chpf Nup43 Hkdc1 Nup88 Csgalnact2 Fbp1 Chst7 Fbp2 Aaas Chst9 Gckr Pklr Ranbp2 Gapdhs Nup214 B3gnt3 Aldoc Bpgm ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 96%10223155 Endogenous sterols Cyp39a1 Ncoa2 Cyp8b1 Cyp1b1 Cyp7b1 Nr1h4 Fdx1 Cyp4v2 Cyp46a1 Cyp27a1 Cyp7a1 Pomc Arnt2 Arnt Ahrr Ahr Cyp11a1 Fdx2 Fdxr Cyp21 Cyp11b3 Cyp11b1 Cyp11b2 Cyp19a1 Rxra DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle Rims1 Tspoap1 Syn3 Syt1 Syn2 Stx1a Ppfia3 Syn1 Cask Ppfia2 Ppfia4 Ppfia1 Lin7a Lin7b Stxbp1 Lin7c Unc13b Snap25 Apba1 Slc18a2 Cplx1 Vamp2 Rab3a FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223851 Free fatty acid receptors Ffar3 Ffar1 Ffar2 TELOMERE MAINTENANCE%REACTOME%R-RNO-157579.1 Telomere Maintenance Terf2 Acd Terf1 Terf2ip Tinf2 Pot1 Ccna1 Ccna2 Ppp6r3 Chtf8 Ppp6c Blm Wrn Chtf18 Tert Ctc1 Stn1 Ten1 Dscc1 Dna2 Shq1 Dkc1 Nhp2 Pif1 Gar1 Wrap53 Rtel1 Nop10 Rpa1 Ankrd28 Rpa2 Rpa3 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Cdk2 Pola1 Pold4 Pold3 Prim2 Prim1 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-RNO-8934903.1 Receptor Mediated Mitophagy Csnk2b Csnk2a2 Map1lc3b Map1lc3a Csnk2a1 Atg5 Fundc1 Atg12 Ulk1 Pgam5 Src ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9033807.1 ABO blood group biosynthesis Fut2 Fut1 Abo2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 96%10225467 Regulation of MITF-M-dependent genes involved in pigmentation Myo5a Rab27a Myrip Sytl2 DEATH RECEPTOR SIGNALING%REACTOME%R-RNO-73887.1 Death Receptor Signaling Itgb3bp Mib2 Otulin Ube2d3 Usp2 Ube2d2 Xiap Usp4 Tradd Cflar Rhoa Ngef Stub1 Ripk1 Tnfsf10 Fas Sos1 Fadd Faslg Rbck1 Ube2l3 Ikbkb Usp21 Mapk8 Traf6 Ikbkg Map3k7 Smpd2 Nfkb1 Smpd3 Traf2 Sharpin Tnf Otud1 Tnfrsf1a Traf1 Rela Spata2 Rnf31 Rack1 Clip3 Sppl2b Sppl2a Ripk2 Casp8 Tbk1 Mapkapk2 Irak1 Tax1bp1 Nfkbia Ikbke Cyld Nsmaf Tab3 Rasgrf2 Tab2 Tab1 Chuk Ngf Birc2 Arhgef7 Tiam1 Mcf2l Tiam2 Prkci Rac1 Adam17 Bcl2l11 Madd Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Arhgef10 Optn Arhgef12 Arhgef19 Rps27a Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Psen2 Ulk1 Sos2 Kalrn Ncstn Aph1a Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Uba52 Gna13 Arhgef1 Obscn Ube2d1 Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Myd88 Plekhg2 Ubb Net1 Arhgef10l Ubc Ywhae Otud7b Ngfr Mag Mcf2 Omg Arhgdia Rtn4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 Gng7 Gng8 Gngt1 Gnat3 Gnb2 Gnb1 Gnai2 Gnai1 Gnb4 Gnb3 Gnai3 Gnb5 Gng11 P2ry12 Gng10-ps1 Gng3 Gng5 Gng4 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors Sumo3 Pias4 Pgr Ube2i Vdr Esr1 Nr1h4 Ppara Thrb Thra Rara Nr5a1 Hdac4 Sumo2 Nr1i2 Pias3 Nr5a2 Pias1 Pias2 Nr1h3 Ar Nr1h2 Nr3c2 Sumo1 Nr3c1 Rxra SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 96%10222913 Signaling by TGF-beta Receptor Complex Tgif1 Tgfb2 F11r Tgif2 Tgfb3 Ltbp3 Ltbp2 Cgn Furin Ltbp4 Ltbp1 Trim33 Ccnk Itgb8 Men1 Itgb6 Ccnt2 Nedd8 Itgb1 Ube2d3 Itgb3 Hdac1 Rnf111 Smad2 Smad3 Smad4 Mapk3 Smad7 Rhoa Stub1 Ski Rps27a Usp9x Skil Smurf2 Ccnc Atp1b4 Tgfbr3 Mtmr4 Uba52 Tfdp2 Tfdp1 Ube2d1 Tgfbr1 Tgfbr2 Rbl1 Strap Bambi Ube2m Prkcz Cdk9 Ubb Pard3 Ubc E2f4 E2f5 Parp1 Fkbp1a Ppm1a Ncor2 Pard6a Smurf1 Cbl Zfyve9 Mapk1 Wwtr1 Sp1 Itga8 Itgav Tgfb1 AUTOPHAGY%REACTOME%R-RNO-9612973.1 Autophagy Map1lc3b Prkab2 Prkab1 Ube2d3 Ube2d2 Atg7 Tomm20 Src Prkn Usp30 Ube2l3 Pex5 Ube2n Atg3 Lamtor3 Mtmr14 Lamtor2 Rb1cc1 Uvrag Atg10 Atg13 Atg14 Tomm22 Chmp2b Atg5 Tbk1 Atg12 Gabarapl1 Mtmr3 Atg9a Pcnt Atg9b Atm Atg101 Chmp3 Pgam5 Tomm40 Chmp7 Ambra1 Chmp6 Wdr45b Wdr45 Arl13b Atg16l2 Mterf3 Atg16l1 Chmp4c Map1lc3a Pink1 Chmp4bl1 Fundc1 Tomm7 Wipi2 Wipi1 Atg4b Atg4c Nbr1 Atg4a Atg4d Csnk2a2 Csnk2a1 Park7 Csnk2b Sqstm1 Optn Rps27a Tsc2 Tsc1 Ulk1 Pik3c3 Chmp2a Gabarap Dync1h1 Uba52 Pik3r4 Dync1i2 Dync1i1 Gabarapl2 Ubb Ubc Mfn1 Mfn2 Rptor RragB Prkaa1 Prkaa2 Mtor Vdac2 Vdac3 Rheb Vdac1 Dync1li2 Becn1 Dync1li1 Tomm70 Slc38a9 Lamtor5 Dynll1 Lamtor4 Prkag3 Dynll2 Rraga Prkag1 Prkag2 Lamtor1 Rragc Rragd Mlst8 Cftr TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels Trpm2 Mcoln2 Trpm1 Trpc5 Trpc4 Trpm8 Trpm7 Trpm4 Trpc4ap Trpm3 Trpc7 Trpm6 Trpc3 Trpv5 Trpa1 Trpv4 Trpv6 Trpv1 Trpv3 Mcoln1 Trpv2 Trpc1 Mcoln3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%10223591 Unfolded Protein Response (UPR) Atf6 Eif2ak3 Mbtps1 Eif2s3 Creb3l3 Eif2s2 Ern1 Crebrf Eif2s1 Atf6b PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%10224255 PI and PC transport between ER and Golgi membranes Pitpnb RHOC GTPASE CYCLE%REACTOME%R-RNO-9013106.1 RHOC GTPase cycle Lman1 Rhoc Ophn1 Vapb Myo9b Arhgap35 Fmnl3 Vamp3 Racgap1 Dlc1 Stard13 Pkn2 Rock2 Rock1 Ccdc187 Pkn1 Tjp2 Arhgap32 Mcf2l Cav1 Acbd5 Flot2 Arhgef17 Flot1 Arhgef11 Pik3r1 Rhoa Arhgef10 Arhgef12 Akap13 Vav2 Fmnl2 Arhgef25 Tfrc Arhgef5 Arhgef1 Abcd3 Abr Stx5 Slk Cavin1 Daam1 Prex1 Bcr Jup Arhgap5 Arhgap1 Stom Arhgef10l Mcam Rtkn Stk10 Maco1 Anln Iqgap3 Diaph3 Diaph1 Arhgap18 Depdc1b Cit Lbr Arhgef28 C1qbp Arhgap21 Mcf2 Arhgap26 Arhgdia VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-RNO-5218921.1 VEGFR2 mediated cell proliferation Sphk1 Pdpk1 Prkcb Plcg1 Prkcd Src Nras Prkca Prkcz Rasa1 Kras Hras Vegfa Kdr BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10225243 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Ptgs2 Alox5 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%10224483 Ficolins bind to repetitive carbohydrate structures on the target cell surface Fcn2 Fcn1 Masp1 Masp2 GBP-MEDIATED HOST DEFENSE%REACTOME%R-RNO-9953170.1 GBP-mediated host defense Casp1 Pim1 Furin Gbp5 Actb Fnta Fntb Pggt1b Actg1 Sfn Gbp2 Gbp1 Gbp3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay Dcps Edc3 Dis3 Edc4 Nt5c3b Pan2 Pan3 Ddx6 Skic3 Skic2 Dcp1a Skic8 Dcp1b Eif4a2 Eif4a1 Lsm3 Lsm5 Lsm1 Lsm6 Eif4a3 Lsm7 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Paip1 Hbs1l Patl1 Exosc3 Exosc2 Eif4e Pabpc1 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME DATABASE ID RELEASE 96%10225177 Noncanonical activation of NOTCH3 Aph1b Ybx1 Psenen Psen1 Notch3 Psen2 Ncstn Aph1a FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation Fgf17 Fgf18 Fgf1 Fgf20 Fgf8 Fgfr3 Fgf9 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10225413 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Pomt1 Ddost Pomt2 Furin Ctnnb1 Pcsk7 Pcsk6 Cdh1 Csnk2a2 Csnk2a1 Jup Mogs Ganab Csnk2b Canx Arhgap32 Spcs3 Spcs1 Spcs2 Pip5k1c Sec11c Sec11a Rpn2 Rpn1 Prkcsh Ostc Ost4 Tmem258b Dad1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 96%10225087 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Hist1h2ai Cbfb Kmt2d Kmt2a Kmt2b Kmt2c H2ac18 Sin3a Sin3b Prmt6 Hist1h2bq Prmt1 Hdac1 Wdr5 Ash2l H2aj H2ab2 H3-3b Hist3h2ba Ep300 H2ac4 ENSRNOG00000068602 Zfpm1 Gata1 Setd1b Setd1a H2bc18 Runx1 Kat2b ENSRNOG00000066901 H2az2 Rbbp5 H2bc4 Hist1h4m H2bc1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Psmb5 Psmb4 Psmb7 Psmb6 Cdc6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk2 Cdc16 KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization Cdsn Klk5 Krtap24-1 Kazn Krtap13-1 Klk8 Krtap10-9 Sprr3 LOC120093742 Tgm1 Krtap11-1 Stfa2l3 Krtap31-2 Casp14 Krtap31-1 Evpl Krt33b Spink6 Cela2a Krt33a Spink5 Krtap2-4l1 Perp Krtap3-1 Klk12 Krt4 Pkp2 Krt2 Pkp3 Krtap3-2 Dsg3 Krt8 Lipk Krt7 Dsg4 Krt5 Dsc2 Krt9 Rptn LOC680428 Lipm Krt27 Klk14 Dsc3 Krt28 Jup Lipn Krt25 Dsp Krt26 Krtap29-1 Krt24 Dsg1 Krt20 Dsg2 LOC134481131 LOC102553726 Krtap5-8 Krt39 Krt36 Krt34 Krt35 Krt32 Krt31 AABR07001416.1 Krtap6-5 Krt18 Krt19 Krt17 Krt14 Krt15 Krt12 Krt13 Krt10 Krtap16-5 Pkp1 Ppl Krtap16-1 Dsc1 Krt6a Krt71 Krt78 Krt76 Krt77 Krt75 Krt72 Krt73 Krt40 Krtap1-3 Krtap1-1 Krtap1-5 LOC134478810 Krt82 Krt80 Krt85 Krt1 Krt86 Krt83 Krt84 LOC102551497 Klk13 GDP-FUCOSE BIOSYNTHESIS%REACTOME%R-RNO-6787639.1 GDP-fucose biosynthesis Fuom Gmds Fcsk Fpgt Gfus Slc35c1 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224305 HS-GAG degradation Gpc1 Gpc3 Agrn Gpc2 Gpc5 Gpc4 Gpc6 Idua Naglu Ids Hpse2 Hpse Sgsh Sdc1 Ctsl Sdc4 Sdc3 Sdc2 HEME SIGNALING%REACTOME%R-RNO-9707616.1 Heme signaling Pgrmc2 Xpo1 Apob Bach1 Ly96 Slc46a1 Apoa1 Hba1 Hbb Clec1b Tlr4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 96%10222147 GTP hydrolysis and joining of the 60S ribosomal subunit LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps2 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 LOC134480579 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rpl23a Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif5b Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses Stat6 Sting1 Nlrp4 Dtx4 Tbk1 Irf3 Ddx41 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-RNO-190704.1 Oligomerization of connexins into connexons Gjb1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-1234174.1 Cellular response to hypoxia Crebbp Cited2 Cul2 Ube2d3 Ube2d2 Arnt Psma4 Psma3 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Vhl Psmb1 Psmb3 Psmb2 Uba52 Eloc Ube2d1 Elob Psma7 Ajuba Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Hif1an Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Egln1 Egln2 Egln3 Epas1 Hif3a Wtip Limd1 Hif1a RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225187 RHOBTB2 GTPase cycle Myo6 Txnl1 Phip Stk38 Hsp90ab1 Cct7 Cct6a Hsp90aa1 Actb Hnrnpc Rbmx Tmod3 Cdc37 Tra2b Twf1 Cct2 Cul3 Rhobtb2 Actn1 Ddx39b Msi2 Srrm1 DNA DAMAGE REVERSAL%REACTOME%R-RNO-73942.1 DNA Damage Reversal Alkbh5 Fto NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224435 Non-integrin membrane-ECM interactions Dag1 Prkca Sdc1 Fgf2 Itgb1 Itgb3 Itgb4 Ddr2 Ddr1 Megf11 Itga2 Sntg2 Agrn Dtna Dtnb Sgcz Snta1 Sntb2 Sntb1 Drp2 Sgce Sgcd Utrn Sgcb Sgca Lama4 Sspn Dmd Sgcg Itga6 Sdc4 Sdc3 Sdc2 Itgav Vtn Tgfb1 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%10225101 Invadopodia formation Adam15 Adam12 Adam19 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%10224719 CD209 (DC-SIGN) signaling Raf1 Icam2 Relb Pak1 Nfkb1 Pak3 Prkaca Crebbp Prkacb Pak2 Lyn Cd209a Ep300 Rela Rps6ka5 Nras Fyn Kras Hras CELL CYCLE%REACTOME%R-RNO-1640170.1 Cell Cycle Ywhag Gsk3b Rbbp4 Rbbp7 Mapk3 Emd Ppp2r5b Ppp2r5a Ube2n Fbxw11 Ppp1cc Ppp1cb Ppp2r5e Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Kpnb1 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Tuba1c Tubal3 Nme7 Rcc1 Cep152 Tuba4a Chmp2b Mapk14 Tubgcp2 Cc2d1b Prkcb Haus4 Spast Tubb2b Haus5 Tubb2a Haus6 Ist1 Pcnt Hdac8 Sfi1 Chmp3 Vrk1 Haus1 Tubgcp6 Chmp7 Tubgcp5 Chmp6 Tubgcp4 Lmna Vps4a Tubgcp3 Sirt2 Cep250 Tuba8 Cep290 Cep78 Chmp4c Cep76 Tuba3b Cep72 Chmp4bl1 Tubb6 Cep164 Cep70 Tubb3 Cpap Tubb1 Mapk11 Tubb5 Banf1 Plk4 Ran Odf2 Ywhab Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Terf2 Acd Terf1 Terf2ip Tinf2 Pot1 Akt3 Akt2 Akt1 Optn Ccne1 Ccne2 Ppp2r3b Cdkn2b Cdkn2d Cdc25a Orc4 Orc6 Orc1 Rab1b Orc3 Kif23 Orc2 Cdt1 Gmnn Ptk6 Cdc7 Chmp2a Kif20a Cdc6 Ppp2r2a Mcm7 Mcm8 Dbf4 Dyrk1a Tfdp2 Tfdp1 Cks1b Cables1 Lin52 Rbl2 Lin54 Rbl1 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Pole3 Pole2 Pole4 Lin9 Rpa1 Rpa2 Wee1 Lin37 Rpa3 E2f1 E2f2 E2f3 E2f4 E2f5 Cdkn1b Pole Cdkn1c Ywhae Lbr Rab1A Rab8a Akap9 Lyn Src Eml4 Wapl Chtf8 Blm Numa1 Wrn Pds5b Chtf18 Pds5a Ctc1 Cdca5 Stn1 Ten1 Dscc1 Dna2 Pias4 Mre11 Ube2i Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Firrm Clspn Rad17 Jak2 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Kmt5a Rfc2 Atm Pola1 Atr Pold4 Tp53bp1 Pold3 Prim2 Prim1 Exo1 Rmi2 Fignl1 Rmi1 Brip1 Brcc3 Smarca5 Herc2 Rnf168 Sumo1 ABRAXAS1 Rnf8 Rhno1 Nsd2 Rad51 Rad50 Fbxl7 Phf8 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Uimc1 Rad1 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Sfn Rps27 Plk3 Rcc2 Kif18a Nudc Dync1h1 Shq1 Spc24 Dkc1 Nhp2 Spc25 Pif1 Xpo1 Gar1 Phf20 Nuf2 Wrap53 Cdca8 Rtel1 Nop10 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Csnk1a1 Ajuba B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Nup50 Cenpm Mis12 Cenpl Dmc1 Cenpk Nup35 Cenpi Nup54 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Nup58 Rangap1 Nup37 Pkmyt1 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Nup188 Kif2c Dync1li2 Tpr Pmf1 Nup160 Dync1li1 Ahctf1 Rae1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Cop1 Mdm4 Nup42 Ndc80 Nup62 Nup43 Ywhaq Nup88 Ywhah Birc5 Aaas Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e Nup214 Ywhaz Spdl1 Nup133 Zfp385a Nup210 Nup155 Bub1 Nup153 Itgb3bp Gtse1 Zwilch Nek9 Ctdnep1 Cnep1r1 Lpin3 Gins2 Lpin2 Gins1 Gins4 Gins3 Phlda1 Ofd1 Esco1 Esco2 Tert Tuba1b Ppp1r12b Ppp1r12a Vrk2 Mastl Arpp19 Hsp90ab1 Ankle2 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Npm1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 Mapk1 Actr1a Ppp2cb Ppp2ca Dctn1 Dctn2 Prkaca Rsf1 Oip5 Mis18a Cenpw Prkca Ppp2r5d Ruvbl1 Prkar2b Gorasp1 Ppp2r1b Ppp2r1a Nipbl Ncapd2 Mau2 Ncapg Smc4 Ppp6r3 Ncaph Smc2 Ppp6c Csnk1d Ccp110 Golga2 Ankrd28 Tpx2 Tp53 Lig1 Fen1 Set H2ab2 Rab2a Blzf1 Espl1 Ncaph2 Ccnh Ncapd3 Fkbpl H2ac4 Ncapg2 Gorasp2 Mcph1 Smc3 Bora Foxm1 Ppme1 Lcmt1 Mis18bp1 Hjurp Abl1 ENSRNOG00000066901 Cdc25b Obi1 Ccnd2 Ticrr Ccnd3 Ccnd1 Stag2 Stag1 Cdk7 Cdk6 H2ac18 Csnk2a2 Csnk2a1 Mnat1 Hist1h2bq Smc1a Hdac1 Csnk2b H2aj Hist3h2ba ENSRNOG00000068602 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Rbx1 Cdk4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-RNO-416550.1 Sema4D mediated inhibition of cell attachment and migration Rac1 Rnd1 Rras Met Sema4d Rhoa Arhgap35 Plxnb1 MITOTIC PROPHASE%REACTOME%R-RNO-68875.1 Mitotic Prophase Nup133 Nup210 Nup155 Nup153 Rab1A Phf8 H2ac18 Prkca Nek9 Ctdnep1 Cnep1r1 Lpin3 Lpin2 Hist1h2bq H2aj Gorasp1 Mapk3 Hist3h2ba Smc4 Emd ENSRNOG00000068602 Smc2 Lmnb1 Ccnb2-ps2 Numa1 Rab1b H2az2 H2bc4 Hist1h4m H2bc1 Ccnb1 Hist1h2ai Vrk2 Golga2 Mastl Arpp19 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Rb1 Nup37 Set Pom121 Plk1 H2ab2 Nup205 Rab2a Prkcb Blzf1 Nup107 Sec13 Ncaph2 Ncapd3 Kmt5a Nup188 H2ac4 Vrk1 Tpr Ncapg2 Cdk1 Nup160 Gorasp2 Mcph1 Lmna Rae1 Mapk1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 ENSRNOG00000066901 Banf1 Aaas Ccnb2 Ranbp2 Nup214 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%10225507 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Cd274 Os9 Rnf5 Sel1l Prkab2 Prkab1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Adrm1 Erlin2 Erlin1 Vcp Prkag3 Prkag1 Prkag2 Erlec1 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%10222223 Signaling by Receptor Tyrosine Kinases Erbb2 Erbb3 Ereg Hnrnph1 Frs2 Frs3 Thbs2 Btc Ranbp9 Rasa1 Pdgfa Pdgfb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Creb1 Fgf17 Col4a1 Fgf18 Col4a2 Fgf19 Braf Fgf10 Ptk2 Hbegf Ide Mapk3 Rps6ka5 Nras Grb2 Fyn Rap1a Kras Sos1 Rap1b Mapk13 Hras Tgfa Fgf20 Fgf23 Areg Atf1 Fgf22 Mapk7 Kit Vrk3 Kitlg Map2k2 Rps6ka3 Map2k1 Rps6ka1 Klb Irs1 Rps6ka2 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Dusp3 Fgf8 Fgf7 Dusp4 Fgf9 Grap2 Dusp7 Hgf Tec Dusp6 Egfr Hdac2 Shc3 Shc2 Mapkapk3 Mapk14 Prkcb Mapkapk2 Pdgfrb Pdgfra Ap2s1 Ralgds Ap2a2 Ap2a1 Ap2b1 Kl Sh3gl2 Mapk11 Flt3 Itgav Ywhab Wwox Nrg2 Furin Nrg3 Ltk Tnk2 Spred1 Met Alkal2 Alkal1 Spred2 Ptpn3 Csk Mapk12 Egf Atp6v0b Itgb1 Trib3 Atp6v0a4 Grb10 Itgb3 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Ptprf Them4 Eps15l1 Pde3b Tlr9 Atp6ap1 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Akt3 Atp6v0d2 Akt2 Atp6v0d1 Akt1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Dock3 Sh3gl3 Sh3kbp1 Dock7 Sh3gl1 Ptk6 Pik3c3 Pik3r4 Rab4a Sh2b2 Prkce Itga2 Mtor Epn1 Crk Mlst8 Kidins220 Galnt3 Arf6 Spry1 Pcsk5 Nedd4 Itga3 Pxn Pak1 Pak2 Lyn Yes1 Src Rhoa Lama4 Ptprz1 Wwp1 Tgfbr3 Gipc1 Ncf1 Ncf2 Ncf4 Aamp Chek1 Lck Thbs1 Igf2 Igf1 Rnf41 Jak2 Lrig1 Tns4 Tns3 Hgfac Hpn Rab4b Gga3 Ctsd Spint2 Spint1 Ranbp10 Cma1 Pcsk6 Cyba Cybb Plat Cul5 Megf11 Pik3ca Shc1 Cav1 Ptpn6 Gab2 Pik3r1 Pik3cb Jak3 Pik3r2 Pik3r3 Gab1 Irs2 Mst1 Mst1r Ptpru Grap Fer Pdpk1 Ctnnb1 Nckap1l Fam83b Crkl Pag1 Rapgef1 Ntrk3 Ntf3 Stub1 Cdc37 Polr2c Polr2a Polr2b Polr2g Polr2h Abi2 Abi1 Polr2e Polr2f Polr2i Polr2j Ncbp2 Nab2 Ncbp1 Dnal4 Egr2 Ptpn12 Gtf2f2 Gtf2f1 Ctnna1 Eps15 Brk1 Jup Nrp1 Nrp2 Shb Ctnnd1 Sh2d2a Elmo1 Axl Alk Mdk Srf Ptn Ptpn18 Ptk7 Bcar1 Wasf3 Ptpn1 Wasf2 Wasf1 Fam83a Diaph1 Fam83d Pdgfc Pdgfd Nckap1 Cyfip2 Cyfip1 Cilp Thbs4 Ntrk1 Ngf Plcg1 Plg Spp1 Fes Elmo2 Rock2 Arhgef7 Rock1 Nck2 Rac1 Pak3 Baiap2 Hsp90aa1 Rps27a Chd4 Sphk1 Uba52 Nck1 Prkcz Igf1r Hdac3 Ptpn2 Ubb Ubc Mmp9 Mapk1 Nos3 Stam Ins1 Ppp2cb Grb7 Ppp2ca Ins2 Prkaca Prkacb Prkcd Prkca Fgfrl1 Calm3 Ppp2r5d Flt1 Flt4 Vegfa Kdr Vegfd Vegfc Pgf Usp8 Vegfb Hgs Ppp2r1b Ppp2r1a Stam2 Flrt1 Flrt3 Flrt2 Ptbp1 Stat6 Stat3 Esr1 Stat1 Ptk2b Stat5a Stat5b Hdac1 Fgfbp3 Fgfbp1 Rbfox2 Esrp2 Esrp1 Tial1 Yap1 Tia1 Ep300 Spry2 Mknk1 Itch Vav3 Vav1 Vav2 Ptpn11 Psenen Psen1 Psen2 Ncstn Aph1a Aph1b Memo1 Hnrnpa1 Sgk1 Ntf4 Rictor Prr5 Bdnf Mapkap1 Ntrk2 Ap2m1 Clta Cltc Cbl Hnrnpf Hspb1 Cdc42 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%10222421 Nucleotide Excision Repair Chd1l Ino80 Ddb2 Ino80e Ppie Ino80d Ino80c Ino80b Usp45 Usp7 Rnf111 Ruvbl1 Rad23a Rad23b Sumo2 Gps1 Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2i Polr2j Ube2n Gtf2h2 Ube2i Gtf2h1 Gtf2h3 Gtf2h5 Cops4 Ercc2 Cops2 Ercc3 Lig3 Znf830 Ube2v2 Lig1 Parp2 Parp1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Ccnh Rfc2 Pold4 Pold3 Actl6a Pias3 Pias1 Sumo1 Cetn2 Sumo3 Xpc Xab2 Cdk7 Ercc1 Ercc4 Tcea1 Mnat1 Polk Prpf19 Actg1 Cops3 Cops6 Cops8 Isy1 Rps27a Ercc6 Uba52 Pole3 Cops7a Pole2 Cops7b Pole4 Rpa1 Rpa2 Mcrs1 Aqr Uvssa Ubb Rpa3 Ubc Pole Nfrkb Rbx1 Tfpt Actr5 Yy1 Actr8 Cops5 Xpa Ddb1 Cul4a Cul4b MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-390648.1 Muscarinic acetylcholine receptors Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-RNO-391160.1 Signal regulatory protein family interactions Grb2 Cd47 Sirpa Tyrobp Skap2 Ptk2b Fyb1 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-RNO-5654693.1 FRS-mediated FGFR1 signaling Fgf17 Frs2 Fgf10 Frs3 Nras Grb2 Kras Sos1 Hras Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 96%10222577 G alpha (q) signalling events Rgs3 Rgs1 Rgs21 Rgs18 Prkcq Rgs19 Rgs13 Lpar5 Lpar3 Lpar1 Creb1 Hbegf Mapk3 Nras Grb2 Kras Sos1 Hras App Mapk7 Ednrb Ednra Rps6ka3 Rps6ka1 Trhr Rps6ka2 Egfr Avpr1b Avpr1a Tbxa2r Btk Gnrh1 Nmbr Fpr2 Ptgfr Nmb Oxtr Lpar6 Xcr1 Grpr Gpr17 Nms Nmu Cckar Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Mchr1 Gpr132 Edn1 Edn2 Gast Edn3 Cckbr Agtr1 F2 Gpr39 Avp Gpr143 Grp Kiss1r Gcgr Nps Ptafr Prkch Prkce Mmp3 Gprc6a Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Npsr1 Plcb4 Prok1 Plcb3 Mgll P2ry10 Mapk1 Plcb2 Plcb1 Gng10-ps1 F2rl1 F2rl2 F2rl3 Prokr2 Prokr1 Prkcd Dgka Gpr65 Gpr68 Dgkb Abhd6 Prkca Dgkd Dgke Dgkg Gna11 Adra1b Gna14 Adra1a Adra1d Gng3 Uts2 Grk2 Tacr1 Dgkh Gng5 Tacr3 Dgki Gng4 Tacr2 Dgkk Anxa1 Gnaq Dgkq Gng7 Gng8 Gngt1 Dgkz Casr Itpr3 Itpr2 Itpr1 F2r Ffar3 Bdkrb2 Ffar1 Gnb2 Daglb Bdkrb1 Gnb1 Ffar2 Nts Gnb4 Trpc7 Kng1 Gnb3 Trpc3 Gnb5 Gng11 Chrm1 Hrh1 Chrm3 Chrm5 Dagla Tac3 Tac1 Opn4 Pmch Ltb4r2 Oxt Trh P2ry2 Grm1 Grm5 Ffar4 Ghrl Htr2a Htr2c Htr2b Lpar4 Ltb4r Xcl1 Agt Kiss1 Ccl9 P2ry6 Ccl6 P2ry1 Uts2b Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Cck Qrfprl Qrfpr Qrfp Hcrt Uts2r Pik3ca Pik3r1 Pik3r2 Pik3r3 Arhgef25 Kalrn Trio Rgs17 Rgs16 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 PRE-MRNA SPLICING%REACTOME%R-RNO-72163.1 pre-mRNA splicing Sde2 Slu7 Srrm2 Snrpepl2 Nkap Hnrnph2 Hnrnph1 Ppig Ppie Rbmx2 Cwc22 Cwc27 Cwc25 Prpf8 Wbp11 Snip1 Cwc15 Gpatch1 Magohb Pqbp1 Ybx1 Rbm22 Rbm17 Ddx46 Bud31 Ddx41 Ddx42 Cwf19l2 Rbmx Polr2c Tra2b Polr2a Acin1 Polr2b Bud13 Polr2g Polr2h Polr2e Polr2f Polr2i Polr2j Ncbp2 Ncbp1 Gtf2f2 Gtf2f1 Snrnp200 Phf5a Fam50a Znf830 Hnrnpr-ps2 Alyref Rnf113a1 U2surp Crnkl1 Rnf113a2 Upf3b Wdr70 Snrpa1 Steep1 C3h9orf78 Ptbp1 Eif4a3 Ppwd1 Gcfc2 Ccdc12 Rbm8a Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Hnrnpa2b1 Srrt Nsrp1 Prpf19 Snrnp40 Prpf18 Eftud2 Fam32a Snrpn Cherp Yju2 Fus Casc3 Isy1 Cdc5l Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Syf2 Puf60 Ppil4 Ppil3 Hnrnpa1 Ppil2 Ppil1 Sap18 Hspa8 Bcas2 Gpkow Rnps1 Smndc1 Pnn Cdc40 Aqr Prcc Pcbp2 Snrpf Pcbp1 Magoh Ddx39b Snrpg Snrpb Tfip11 Dhx8 Hnrnpr Hnrnpu Rbm10 Dhx38 Dhx35 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx16 Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 Srrm1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex Cdc6 Mcm8 Orc4 Orc6 Orc1 Orc3 Orc2 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%10222513 CREB1 phosphorylation through the activation of Adenylate Cyclase Prkar1a Prkar2a Prkar1b Prkar2b Prkaca Prkacb TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-RNO-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk9 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%10224555 Regulation of HSF1-mediated heat shock response Nup133 Nup210 Nup155 Nup153 Gsk3b Hspa5 Hsf1 Hspa1b Hspa1a Mapk3 Hspa8 Rpa1 Nup93 Rpa2 Nup50 Hsph1 Dnajc2 Rpa3 Hspa1l Nup35 Hikeshi Hspa14 Nup54 Hspa13 Nup98 Rps19bp1 St13 Ywhae Nup58 Hspa12b Hspa12a Hspa2 Nup37 Bag5 Pom121 Bag3 Bag2 Nup205 Bag1 Mapkapk2 Nup107 Sec13 Dnajb6 Hspa9 Nup188 Hspa4 Tpr Nup160 Rae1 Mapk1 Ndc1 Sirt1 Nup85 Nup42 Nup62 Nup43 Nup88 Dnajb1 Aaas Ranbp2 Nup214 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 Runx3 Cbfb Ccnd1 Crebbp Ctnnb1 Tcf7 Tcf7l1 Tcf7l2 Tead4 Psma4 Smad3 Psma3 Smad4 Yap1 Psma6 Src Ep300 Psma5 Psma2 Tead3 Psma1 Rps27a Tead2 Psmd12 Psmd11 Psmd14 Psmd13 Kat2b Psmb5 Psmb4 Smurf2 Psmb7 Psmb6 Lef1 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Tp53 Psmb6l1 Kat2a Maml3 Psmd7 Rbpj Psmd6 Hdac4 Psmd8 Maml1 Psmd2 Maml2 Psmd1 Adrm1 Smurf1 Tgfb1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes Uba52 Prkci Irak1 Ngf Sqstm1 Rps27a Ngfr Myd88 Ikbkb Ubb Ubc Traf6 Ripk2 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 96%10222345 Beta oxidation of butanoyl-CoA to acetyl-CoA Echs1 Hadh Acads DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224699 DAG1 core M1 glycosylations Pomt1 Pomgnt1 Pomt2 Dag1 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%10224629 RHO GTPases Activate NADPH Oxidases Pik3r4 Mapk14 Rac1 Nox3 Prkcb Nox1 S100a9 Mapk3 Prkcd Rac2 S100a8 Noxa1 Ncf1 Ncf2 Noxo1 Prkca Ncf4 Cyba Mapk1 Cybb Prkcz Mapk11 Pik3c3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%10223903 Mitochondrial tRNA aminoacylation Ppa2 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 96%10222203 The phototransduction cascade Grk4 Nmt2 Metap1 Metap2 Camkmt Gucy2e Sag Gucy2f Cnga1 Pde6a Pde6b Gnat1 Rcvrn Guca1b Guca1a Calm3 Nmt1 Rho Gngt1 Gnb1 Gnb5 Fnta Fntb Rgs9bp Ppef1 Pde6g Rgs9 Grk1 Cngb1 KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation Omd Acan Ogn Glb1l Kera Gns Prelp Glb1l3 Glb1l2 Glb1 Fmod Galns Hexa Hexb Lum PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%10223047 PI-3K cascade:FGFR1 Fgf17 Pik3ca Frs2 Fgf10 Pik3r1 Grb2 Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 Gab1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Cyp39a1 Hsd3b7 Akr1d1 Amacr Cyp8b1 Akr1c18 Akr1c12l1 Akr1c19 Slc27a2 Akr1c21 Cyp46a1 Cyp27a1 Slc27a5 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 96%10222645 Aflatoxin activation and detoxification Cyp3a9 Cyp3a18 Mgst3 Acy3 Cyp3a1 Mgst2 Cyp1a2 Mgst1 Cyp3a62 Ggt1 Ggt5 Cyp2a2 Cyp3a2 Ggt7 Cyp2a1 Ggt6 Akr7a3 Akr7a2 Cyp2a3 Acy1a Dpep1 Dpep2 RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway Cyp26a1 Rdh11 Rdh10 Akr1c18 Rdh13 Akr1c12l1 Rdh14 Akr1c19 Adh4 Adh1 Akr1c21 Crabp1 Akr1c3l1 Aldh1a1 Akr1c12 Rdh7 Akr1c1 Akr1c13 Akr1c9 Dhrs4 Dhrs3 Aldh8a1 Aldh1a2 Aldh1a3 Cyp26b1 Dhrs9 Cyp26c1 Sdr16c5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D Psmb6 Psmb1 Ccnd1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdk4 Psmb5 Psmb4 Psmb7 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223089 Intestinal hexose absorption Slc2a2 Slc5a1 Slc2a5