PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 96%10225211 Pre-NOTCH Transcription and Translation 304815 84006 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 24708 287984 65138 94198 294790 25515 29673 295052 29671 29670 29677 29676 29675 50522 310806 305420 361831 366381 292588 81827 293155 292263 25203 83806 311078 192255 114494 287280 361765 100912032 360643 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling 680149 84420 117281 58979 116590 140908 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 81662 81664 60341 29691 64199 24654 286924 83506 24611 315648 79218 360616 24627 24626 25638 81636 245986 25238 24668 60449 25031 293508 302950 85240 363193 294962 64532 25521 25686 24673 25289 25643 25601 25725 24679 83579 29241 24672 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME DATABASE ID RELEASE 96%10223491 SLC-mediated transport of neurotransmitters 171148 83612 298340 79213 309111 282712 117100 83511 681896 171163 84487 116509 266767 24904 113918 664630 25553 29503 24898 116638 79212 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%10223741 Surfactant metabolism 302973 24773 29316 25369 246326 25425 245977 25548 25083 25350 314799 24175 170568 494021 50683 29300 29597 362859 84395 192155 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224927 Regulation of TP53 Expression 24842 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-110362.1 POLB-Dependent Long Patch Base Excision Repair 290027 362600 84490 25591 79116 83507 29240 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-RNO-8878171.1 Transcriptional regulation by RUNX1 64033 25622 691504 297893 362675 24890 310678 307151 315606 302783 24829 24828 303518 296732 100362634 25193 313038 304690 117056 309626 363014 685909 680615 288563 25720 310258 361925 303175 303730 25697 64627 295384 25172 60421 301164 306970 304794 266713 361391 315136 83833 681178 311567 81650 313507 500453 361825 290829 58919 361944 100359816 306945 297867 25159 362093 102550344 501403 311860 680498 301020 171046 365877 116549 84389 85471 114483 29175 309001 50662 690795 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 CAM PATHWAY%REACTOME%R-RNO-111997.1 CaM pathway 83506 84420 24244 170538 81636 64508 25238 81742 25050 24681 293508 29699 302950 24680 64532 60341 25521 29691 25289 25725 24679 29241 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10223803 Sialic acid metabolism 25547 311530 316642 116696 298071 117523 365984 303692 363103 25280 117185 304860 301155 291325 407765 363040 64442 64445 287920 29758 316033 114711 364901 83505 313139 25197 362924 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%10224003 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 362474 301624 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-RNO-9909648.1 Regulation of PD-L1(CD274) expression 680498 365877 116549 690795 287772 292766 289874 64156 94201 290783 29669 65248 29668 362040 56010 29425 116967 100360846 83712 290823 117263 192275 25581 407784 64562 29666 313048 100188932 303353 116643 365388 309304 290638 117262 686092 85492 301626 25520 83803 84027 287984 313648 65138 362891 94198 373545 688041 363160 29673 301555 499342 29671 287643 29670 64701 29677 690315 29676 78975 29675 360967 50522 310678 315606 302783 24829 24828 81827 83806 311078 192255 117056 287280 361765 685909 100912032 680615 303175 64627 306970 304794 81650 290829 58919 306945 362093 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-RNO-419408.1 Lysosphingolipid and LPA receptors 310812 116744 29415 29733 500317 66025 306792 298062 60399 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%10222759 Mitochondrial transcription initiation 289307 83474 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-RNO-375165.1 NCAM signaling for neurite out-growth 25614 24525 25150 81646 313845 116590 290905 308458 50689 116696 117523 24605 289257 293621 305614 64159 306628 24586 314251 81504 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%10222839 Toll Like Receptor 5 (TLR5) Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%10224273 Elastic fibre formation 24914 81809 293677 24511 83727 59086 59107 29302 25043 59106 85272 292734 25717 296456 311061 290350 309380 313662 83838 54281 315714 29373 500245 29158 362800 252835 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-RNO-381070.1 IRE1alpha activates chaperones 498013 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223831 Sodium-coupled sulphate, di- and tri-carboxylate transporters 503568 58980 DEPURINATION%REACTOME DATABASE ID RELEASE 96%10222431 Depurination 303175 365877 64627 306970 690795 302783 24829 24828 290232 297758 81528 170841 500054 306945 307798 307861 685909 680615 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10225011 Rab regulation of trafficking 303734 300147 288779 317580 64862 25532 25531 313340 29414 299075 316017 311880 292074 114638 367915 315999 361697 362983 315756 84379 311911 25530 501550 289350 360768 363235 691042 64670 288700 307868 365793 292886 689102 64633 292760 311494 501854 315059 313234 24855 25183 29662 312257 362599 117103 299799 307039 363123 290746 499768 361987 294709 171452 361227 363326 306229 360827 287427 94193 24942 287709 79121 94197 361555 24185 60445 29753 25233 252916 84590 50645 287110 367073 365372 313493 246324 29448 295333 207119 81830 246294 81754 79434 315668 81756 680465 29885 58974 84589 308942 366896 360956 309678 360797 266688 CREATINE METABOLISM%REACTOME%R-RNO-71288.1 Creatine metabolism 79213 117100 50690 24264 24265 50676 81660 PURINE SALVAGE%REACTOME%R-RNO-74217.1 Purine salvage 25095 290029 362015 192357 79127 24165 117533 24465 25028 25368 297389 292072 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-RNO-3928663.1 EPHA-mediated growth cone collapse 25150 81515 117273 83805 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223823 Unblocking of NMDA receptors, glutamate binding and activation 117284 58948 24244 64053 24409 24408 24410 25400 24245 24246 24412 24411 29629 29628 29627 83613 29495 50592 25252 171140 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%10225435 TGFBR3 regulates TGF-beta signaling 81810 83823 29610 25387 25388 29591 81809 59086 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223563 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 116700 25329 314993 24890 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-RNO-202430.1 Translocation of ZAP-70 to Immunological synapse 25300 25710 24986 24932 295338 294269 300678 313050 24981 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-RNO-9732724.1 IFNG signaling activates MAPKs 360697 116590 24703 116465 25712 50689 24514 LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis 59294 89809 85241 288003 361698 25737 301323 288414 289758 116468 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 96%10224365 Metabolism of Angiotensinogen to Angiotensins 113902 24715 302668 25627 113936 252929 302526 290257 24179 24310 64017 266704 54242 24590 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA 25287 171155 170670 THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome 304987 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine 293779 353317 246263 688536 361637 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 96%10225491 Antigen processing: Ub, ATP-independent proteasomal degradation 94198 29673 29671 29670 29676 29675 29669 29668 29425 100360846 29666 24968 24967 291983 85492 29614 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223625 Orexin and neuropeptides FF and QRFP bind to their respective receptors 379044 25593 500157 310327 78964 25723 25605 60337 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-RNO-9026762.1 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 114097 499689 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%10224573 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 287102 80722 293897 295445 502097 114107 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling 313845 25704 171081 65038 116689 25513 25326 25746 116562 366508 116630 24514 54259 170911 60664 84477 85243 85385 81504 RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP 54318 117019 296302 64514 171145 192234 299027 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%10225287 tRNA modification in the mitochondrion 319113 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 96%10225157 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 25513 29376 366508 361388 298947 24514 170911 24335 497931 85243 81515 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 96%10224401 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 287454 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 96%10223473 Biosynthesis of specialized proresolving mediators (SPMs) 114097 499689 287454 29527 29328 29624 79242 81639 29277 171522 25086 299732 24296 24297 266682 252931 65030 25290 NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism 113975 685068 499391 292085 295692 84404 117021 362335 687711 363462 366016 58958 65160 691231 362557 65274 113929 100362099 64301 297522 245922 681031 81738 362688 683983 53372 316108 25497 310769 499974 84473 312947 171365 680737 294429 291794 287830 291874 362281 PREDNISONE ADME%REACTOME%R-RNO-9757110.1 Prednisone ADME 498790 266685 501907 286954 299270 286989 307092 25116 25117 291283 361266 171516 24186 307096 364773 498789 191574 266682 252931 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-RNO-110330.1 Recognition and association of DNA glycosylase with site containing an affected purine 303175 365877 64627 306970 690795 302783 24829 24828 290232 297758 81528 500054 306945 307798 307861 685909 680615 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%10223411 Presynaptic depolarization and calcium channel opening 58942 25297 25398 84347 116600 50688 306243 300992 140725 CHYLOMICRON ASSEMBLY%REACTOME%R-RNO-8963888.1 Chylomicron assembly 292697 54225 310900 25080 25081 287276 25649 25506 25728 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-RNO-113418.1 Formation of the Early Elongation Complex 292778 288651 84389 288588 361580 316123 689116 502227 266713 294693 83503 311796 298075 361365 690966 117017 305455 679203 291703 363633 498109 289561 GPCR LIGAND BINDING%REACTOME%R-RNO-500792.1 GPCR ligand binding 360579 29581 171056 365228 306307 25555 29238 89808 81644 689869 29595 81645 29237 192205 29235 192206 170634 24221 29234 84475 29471 54226 171044 24318 102552838 360918 294123 314386 171519 24797 294124 685243 24677 25524 25645 294121 114098 114099 29446 81672 25087 84023 399475 294807 25653 25652 24323 24326 81779 24448 81668 29335 301086 690158 367315 24418 24659 266997 24417 24419 24772 114105 24414 60628 24416 25504 24415 445269 309212 25187 83633 500091 171371 494319 497942 56813 117064 64680 498475 192648 192649 246358 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 56820 310444 25075 25195 29555 192646 501177 500089 100310876 301066 25726 113914 679957 287910 298006 116506 24875 29407 25040 78981 78980 171158 78983 362454 78985 498335 117041 25616 366270 24769 366274 29538 117029 245920 83518 24889 246219 266607 60669 25051 60665 29413 29412 78976 25298 679975 54305 85268 78979 302378 25706 25026 170926 259224 259222 25029 24613 25380 25264 24174 690448 25024 60432 25265 361383 363682 29180 288995 378939 498791 691774 116677 29636 319107 64803 319105 24182 25033 29191 24180 287673 499194 113959 24717 25245 63843 25248 170704 117518 24953 25007 260319 680188 25360 58812 287561 287562 24604 63850 502757 171104 171108 500101 83567 24166 310869 29290 171101 58949 116700 25329 64199 79218 245986 24179 60449 294962 25601 83579 25605 60337 379044 680149 25593 500157 58979 310327 78964 25723 114117 24400 81667 29316 25369 25083 24175 29597 287730 24816 24938 25107 25108 25229 688605 689936 316019 29385 246075 282832 116498 25340 554302 50672 25342 29141 60590 292409 58959 64042 53949 308408 25477 294394 246759 58965 29397 24260 58966 25111 292419 29151 24476 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25449 81753 29363 54258 84348 66025 25321 306792 24232 298062 81752 60399 310812 24473 305236 116744 50577 29415 289023 29733 171551 500317 65032 24925 24807 24806 24808 24929 290493 292794 117549 24247 316259 295144 316137 192223 317219 25570 81503 24241 29256 498289 362505 366668 100360071 497196 100911796 497078 25542 24695 64636 302619 81648 299242 117264 57305 81657 353250 308163 84007 24694 117027 57302 89810 100270683 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se 363285 25331 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-RNO-9759194.1 Nuclear events mediated by NFE2L2 287984 65138 94198 29673 29671 29670 29677 83619 29676 78975 117254 29675 50522 81827 83806 311078 192255 287280 361765 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-RNO-76042.1 RNA Polymerase II Transcription Initiation And Promoter Clearance 292778 84389 288651 288588 361580 316123 502227 291773 294693 317256 83503 83828 170844 361365 81673 690966 83830 171152 117017 309638 288533 373541 291703 293345 363633 294018 498109 289561 303918 117526 287571 266713 REGULATION OF BACH1 ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225359 Regulation of BACH1 activity 304127 FCGR ACTIVATION%REACTOME%R-RNO-2029481.1 FCGR activation 25734 289211 25150 79113 81515 300678 100360919 25155 83805 295279 SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes 292767 366174 680264 689349 100910102 680912 290989 362623 METHYLATION%REACTOME DATABASE ID RELEASE 96%10222323 Methylation 140925 290947 24297 25331 683630 81522 171347 690050 29443 24267 ERK1 ERK2 PATHWAY%REACTOME%R-RNO-5684996.1 ERK1 ERK2 pathway 300980 116663 60587 29302 287772 292766 64156 29669 29668 83805 64053 29425 100360846 24408 24410 117263 25400 25581 24245 24246 24412 29666 54237 303353 365388 117262 83613 29495 85492 25252 171140 287984 117284 65138 58948 94198 29673 25387 25388 29671 29670 29677 29676 29675 50522 81827 24703 83806 311078 24514 192255 100912032 315648 24498 363193 25344 25467 309179 116499 432361 24673 60352 64030 24827 25114 63995 25597 114856 192126 24672 25594 362045 58960 117281 65142 363272 116590 25444 25443 24244 54250 81511 309399 192213 314612 29369 29368 24592 25704 309153 171081 315707 299617 170583 25513 25326 170582 24366 25746 25454 116562 24367 297682 116630 170577 29496 170911 309168 170579 25453 85243 29372 85385 66017 64511 29349 29348 84489 66023 65179 25433 29376 25313 25676 25318 25317 314850 89807 312664 685269 170633 361679 288924 24553 25523 25525 312754 79114 170668 24329 293847 364052 305679 295347 114513 100909827 24446 316213 299147 246781 305203 56011 289080 29542 311406 360814 25622 498596 305539 25514 24669 83504 29434 296072 310533 362572 498576 302808 314596 24888 60427 170851 687346 60662 100361294 25267 59322 25022 29622 25266 59325 171337 29183 24629 24628 64363 309548 304893 24716 361171 170700 361601 64022 289625 25136 170818 171109 114486 60464 364686 301555 24605 289257 293621 305614 64159 24586 314251 81504 25614 24525 25150 313845 308458 50689 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism 24192 361730 684314 24188 24788 25659 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-RNO-163210.1 Formation of ATP by chemiosmotic coupling 26196 171069 29754 362749 641434 690441 192241 171375 171374 65262 245958 140608 300677 171082 94271 245965 26197 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 96%10221925 Mitotic G1 phase and G1 S transition 311860 117281 84389 29414 114483 399489 295596 299112 312538 117104 305171 360908 316273 296178 81758 313479 682033 362485 291927 307126 360621 304573 292787 308937 59102 684111 29728 100360427 312046 298098 292071 25164 83571 301430 288532 287772 366275 292766 313138 64156 494444 94201 680111 29669 81515 171102 29668 361178 83805 362385 29425 25255 100360846 499655 307585 117263 25581 29666 313048 303353 365388 117262 85492 24708 287984 65138 94198 294790 29673 295052 64033 29671 29670 29677 297893 29676 29675 50522 81827 25193 83806 311078 24514 192255 114494 287280 301323 100912032 24185 85241 315648 25233 266713 58919 24673 24672 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222781 MTOR signalling 310091 298514 362045 373545 64226 56011 116636 25435 297960 290291 24644 24855 29414 24666 83840 78975 24185 60445 25233 65248 292887 303605 295357 29304 64562 314621 26954 117044 501146 117043 117045 56718 25520 360776 83803 25639 308869 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10225127 Selenocysteine synthesis FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-RNO-5654712.1 FRS-mediated FGFR4 signaling 29349 24525 313845 25444 54250 25622 25317 170700 314850 289625 29369 29368 60464 170583 170582 116499 24605 293621 25114 66017 81504 316213 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%10222979 Glutathione conjugation 499689 290401 64352 408206 116568 295037 291394 81869 25260 360994 494499 25283 29566 29487 681913 156275 297029 362196 24421 24423 24422 25458 29739 24424 24426 309465 494500 116684 501110 58962 78959 171341 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%10223867 Smooth Muscle Contraction 24244 288057 304816 66012 25202 296313 289759 24852 24851 25687 25118 25206 29431 171115 500450 501203 282843 24584 305679 29432 50685 360820 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-RNO-72764.1 Eukaryotic Translation Termination 24206 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis 59294 290805 89809 308755 84490 364996 85241 290232 297758 288003 500054 361698 307798 25737 307861 301323 288414 59102 303238 289758 116468 294025 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-RNO-5693532.1 DNA Double-Strand Break Repair 290805 308755 289757 363251 497672 293452 64557 156826 304719 116554 83508 363924 102551085 303194 315969 290907 363247 498119 499966 290997 64046 290631 502935 316794 498749 171366 171525 85482 289777 287634 192218 114212 361767 293489 298534 287927 685055 65179 310034 297561 25573 313539 361815 306734 301442 305000 499417 301128 300711 299638 302982 690043 288079 297627 292172 316235 296099 360748 360588 497856 302953 64012 499870 294800 293678 24842 290027 498265 368002 314380 84490 25591 29722 498411 308669 293719 291787 289468 259171 100361529 689055 25019 297486 140583 362827 84495 24829 362704 306257 303175 64627 306945 311860 299112 304573 59102 298098 64156 362385 295052 50522 192255 288003 114494 361698 25737 100912032 288414 289758 116468 59294 89809 116725 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%10224271 Molecules associated with elastic fibres 59106 85272 292734 25717 296456 311061 313662 83838 29373 500245 29158 362800 252835 81809 293677 24511 59086 59107 29302 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 96%10223389 Metabolism of amine-derived hormones 25430 308129 246281 65162 116700 25653 302899 24848 24311 317675 266807 25699 114613 311374 29475 25085 25120 24661 79107 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 295596 29675 50522 312538 316273 81827 296178 313479 83806 311078 291927 192255 114494 360621 287280 100912032 29728 292071 301430 288532 287772 292766 313138 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10225423 Regulation of MITF-M-dependent genes involved in apoptosis 25094 690660 297893 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-RNO-9023661.1 Biosynthesis of E-series 18(R)-resolvins 81639 299732 25290 29328 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 96%10221977 Cell Cycle Checkpoints 290805 308755 497672 64557 363924 303194 315969 290997 64046 290631 303024 316794 85482 192218 114212 298534 287927 685055 310034 361815 306734 305000 300711 690043 297627 296099 360588 497856 64012 294800 498411 308669 291787 289468 100361529 140583 362827 362704 29753 306464 679342 300126 287624 291441 685474 257649 257644 64041 25448 94266 29489 363028 25576 25578 315164 25577 304951 289150 361416 363174 81655 303037 307511 311575 363059 114764 29564 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287101 113927 287598 307805 311191 29648 500545 102555739 295661 313017 304798 65201 681185 308443 296137 360860 317252 305270 83572 140734 58936 681050 58822 58945 684439 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 117262 85492 288671 290875 287984 65138 94198 25515 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 25203 83806 311078 192255 288003 114494 287280 361765 100912032 288414 360643 116468 315648 363193 309179 24673 24672 117281 312754 294429 287830 24842 299147 292085 56011 24669 24829 297522 81738 683983 303175 64627 306945 295596 312538 360908 316273 296178 313479 362485 291927 307126 360621 308937 59102 29728 312046 83571 301430 288532 313138 171102 56010 84027 116725 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization 25513 313845 81745 317676 170911 84477 85243 81515 100360919 85385 25155 81504 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-RNO-9025106.1 Biosynthesis of DPAn-6 SPMs 81639 287454 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 96%10223319 TCF dependent signaling in response to WNT 117281 287102 80722 293897 295445 502097 114107 312754 299147 297893 24185 25233 304794 81650 25578 290829 362093 102550344 116549 85252 113927 58822 291678 287772 292766 304832 64156 301965 161452 29669 64558 29668 120099577 79257 29425 503000 100360846 501584 29382 498997 498233 117263 25581 691857 63879 29666 103691373 291209 303353 679110 365388 65027 25565 295251 117262 85492 364754 289026 29417 312451 84027 287984 29134 65138 24881 94198 310704 64512 317674 29673 301555 300837 313589 29671 312936 29670 309419 29677 308051 29676 499918 29675 299802 84353 50522 679158 282581 290317 266772 500863 81827 246768 360990 84424 303251 83806 303412 311078 364712 192255 303811 293165 24205 361765 140585 100912032 83721 140586 300673 315648 363193 309179 24673 24672 REGULATION OF CDH1 FUNCTION%REACTOME%R-RNO-9764561.1 Regulation of CDH1 Function 287984 65138 94198 29673 29671 29670 29677 29676 29675 84353 50522 81827 83806 311078 192255 100912032 313474 292064 81679 500870 25150 50654 25697 25751 311163 83502 83427 287772 292766 64156 29669 29668 83805 29425 100360846 117263 25581 29666 303353 365388 305679 117262 85492 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-RNO-159230.1 Transport of the SLBP Dependant Mature mRNA 113975 292085 295692 117021 362335 366016 689116 58958 362557 298075 65274 113929 297522 245922 81738 683983 53372 25497 499974 681062 59087 690585 294429 117045 287830 291874 362281 INFLAMMASOMES%REACTOME%R-RNO-622312.1 Inflammasomes 300732 117514 282817 315435 58923 116484 29665 301252 360557 304987 24888 290408 287362 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling 315599 246244 312937 192255 299827 292892 64156 311430 50522 100912032 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-RNO-1638074.1 Keratan sulfate keratin metabolism 316583 305571 84400 362275 84468 293667 367145 307859 294673 314771 292073 64507 313536 500961 494342 299825 81682 58968 65196 363040 64442 64445 316033 362924 290638 295934 300757 301525 291015 303923 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224157 PI3K events in ERBB2 signaling 25513 25433 25313 24329 361388 432361 498596 29496 170911 64022 59325 81504 TRKA ACTIVATION BY NGF%REACTOME%R-RNO-187042.1 TRKA activation by NGF 59109 310738 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 96%10222873 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 116554 116725 362418 311245 308267 50658 309295 317546 500133 363520 313121 362491 363855 25272 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%10224765 Phospholipase C-mediated cascade; FGFR4 29349 25444 54250 25317 170700 289625 29369 29368 60464 170583 170582 25738 116499 25114 66017 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI 297694 362039 691905 29354 24913 29692 308309 295631 298579 29526 29359 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling 306636 287989 25150 83709 686310 316369 114559 312275 24338 29433 83841 360546 363875 83805 29431 501203 29432 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors 116590 24244 25513 81664 170911 60664 85385 192218 65179 25433 25313 296849 311254 301128 25061 311764 29149 497941 24705 500633 685072 685750 299331 24329 81687 360420 81686 24919 170906 25682 58851 246332 363026 363425 266603 266686 64466 308190 25335 84578 361810 304157 297893 289950 500569 24890 298942 310678 25149 81654 24172 302783 81530 24829 89813 24828 362110 353252 294515 25718 362809 260321 117098 117056 25154 170635 365755 685909 302711 680615 500629 25522 59325 313210 29563 29183 24185 313689 303175 498790 116676 83574 25233 361967 64627 297805 24600 312495 307092 60421 60349 301164 298184 306970 25098 291283 64022 170897 361266 171068 361391 171516 140868 307096 364773 498789 191574 24188 306945 680498 365877 292778 288588 85471 29414 316123 50662 85252 690795 83503 361365 690966 117017 363633 498109 289561 83571 81745 83805 306792 83828 83830 84424 24605 293621 117526 286924 25614 24525 81646 50689 81647 314322 301252 25686 25643 24827 24516 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%10221933 Polymerase switching 59294 89809 85241 288003 361698 25737 301323 288414 289758 116468 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 96%10225277 Signaling by NOTCH4 24185 25578 406162 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 96%10224195 Tandem pore domain halothane-inhibited K+ channel (THIK) 64120 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 96%10223183 p75NTR regulates axonogenesis 83765 317598 450224 24596 310738 360678 29409 117273 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223365 ER to Golgi Anterograde Transport 315059 362599 297522 287427 29183 367073 29489 81754 64154 680465 289994 293456 64310 362162 361073 81655 54350 287276 309451 309678 60355 65134 297428 290994 29564 300888 246117 79120 304290 54400 58842 363136 690252 299075 171121 252902 192243 299850 292074 310411 24648 300743 64462 100912115 56042 252853 89868 140940 60384 501550 290659 64351 65165 300674 291990 25423 685144 299121 362237 306264 140734 309010 140673 503165 246310 58945 690961 361705 301012 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 304978 116666 117513 100360302 94189 29167 84428 79117 361207 50592 252889 58817 93646 314030 295461 294010 361577 289257 305614 64159 314251 308458 252929 24827 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223669 Hormone ligand-binding receptors 171158 81668 25477 25447 25360 116700 25449 25194 25329 366668 25653 SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222105 Succinyl-CoA Biosynthesis 299201 360975 298942 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%10223631 Metabolism of cofactors 24185 365592 24244 24600 296128 498332 366013 299195 25249 24479 313521 29309 29244 308453 498909 25523 29498 171128 304542 50655 360887 299331 29270 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%10222253 Formation of editosomes by ADAR proteins 81635 25367 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%10222895 Cyclin A B1 B2 associated events during G2 M transition 117281 25515 84389 295052 85252 287101 117104 25203 682033 114494 361643 361088 308937 308768 306102 689296 171103 316602 361613 315648 266713 171102 24673 54237 363174 307511 24672 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223901 Interleukin-4 and Interleukin-13 signaling 25084 287287 25326 362862 116553 25125 500616 24514 100361294 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 96%10224791 RAF MAP kinase cascade 300980 116663 60587 29302 287772 292766 64156 29669 29668 83805 64053 29425 100360846 24408 24410 117263 25400 25581 24245 24246 24412 29666 303353 365388 117262 83613 29495 85492 25252 171140 287984 117284 65138 58948 94198 29673 25387 25388 29671 29670 29677 29676 29675 50522 81827 24703 83806 311078 24514 192255 100912032 315648 363193 25344 25467 309179 116499 432361 24673 60352 64030 24827 25114 63995 25597 114856 192126 24672 25594 362045 58960 117281 65142 363272 116590 25444 25443 24244 54250 81511 309399 192213 314612 29369 29368 24592 25704 309153 171081 315707 299617 170583 25513 25326 170582 24366 25746 25454 116562 24367 297682 116630 170577 29496 170911 309168 170579 25453 85243 29372 85385 66017 64511 29349 29348 84489 66023 65179 25433 29376 25313 25676 25318 25317 314850 89807 312664 685269 170633 361679 288924 24553 25523 25525 312754 79114 170668 24329 293847 364052 305679 295347 114513 100909827 24446 316213 299147 246781 305203 56011 289080 29542 311406 360814 498596 305539 25514 24669 83504 29434 296072 310533 362572 498576 302808 314596 24888 60427 170851 687346 60662 25267 59322 25022 29622 25266 59325 171337 29183 24629 24628 64363 309548 304893 24716 361171 170700 361601 64022 289625 25136 170818 171109 114486 60464 364686 301555 24605 289257 293621 305614 64159 24586 314251 81504 25614 24525 25150 313845 308458 50689 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-RNO-2534343.1 Interaction With Cumulus Cells And The Zona Pellucida 500052 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%10224701 Matriglycan biosynthesis on DAG1 114489 308390 140568 313139 293667 361368 362567 311202 362520 299841 493574 257647 SWI SNF CHROMATIN REMODELERS%REACTOME%R-RNO-9932451.1 SWI SNF chromatin remodelers 361925 301020 83833 292404 303518 293514 296732 301235 361825 368001 292622 287876 299186 361374 297867 361295 305589 192352 361711 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation 29349 499349 29348 25444 25443 54250 25317 170700 29369 29368 170633 60464 170583 116499 60662 170579 25022 66017 64535 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling 306618 66013 500608 113894 287537 64314 287418 362548 64639 84009 116554 120099896 310635 311647 310999 57027 78966 307398 81736 117020 25493 309653 301059 303634 310738 301334 295449 300802 363460 293024 100362710 29192 362648 292788 295378 298404 25402 310460 307098 246174 117089 363509 81751 114559 84006 140898 361921 304109 64156 310192 64547 687105 363875 29491 117273 289231 114513 50522 192255 100912032 29753 313845 311245 83765 317598 450224 363520 24596 360678 29409 362491 84351 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223119 Gap junction degradation 116561 24392 54241 79128 140694 25751 116563 315840 83800 P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB 113894 84006 64156 311245 50522 81736 25493 301059 24596 363520 310738 362491 192255 100912032 84351 PERK REGULATES GENE EXPRESSION%REACTOME%R-RNO-381042.1 PERK regulates gene expression 54318 296302 29702 299027 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-RNO-8850843.1 Phosphate bond hydrolysis by NTPDase proteins 85260 64467 309390 316077 613267 314312 INTERLEUKIN-6 SIGNALING%REACTOME%R-RNO-1059683.1 Interleukin-6 signaling 24498 25125 25622 24514 100361294 89829 500985 MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 96%10222403 MAPK family signaling cascades 84009 300980 116663 60587 29302 309175 58840 84482 64551 313838 64465 360635 85252 287772 292766 64156 29669 29668 83805 64053 29425 100360846 24408 24410 117263 25400 25581 24245 24246 24412 29666 54237 303353 365388 117262 83613 29495 85492 25252 171140 287984 117284 65138 58948 94198 29673 25387 25388 29671 29670 29677 29676 29675 50522 310806 81827 24703 83806 311078 24514 192255 100912032 315648 293508 24498 363193 25344 25467 309179 116499 432361 24673 60352 64030 24827 25114 63995 25597 114856 192126 24672 25594 362045 58960 117281 65142 363272 116590 25444 25443 24244 54250 81511 309399 192213 314612 29369 29368 24592 25704 309153 171081 315707 299617 170583 25513 25326 170582 24366 25746 25454 116562 24367 297682 116630 170577 29496 170911 309168 170579 25453 85243 29372 85385 66017 64511 29349 29348 84489 66023 65179 25433 29376 25313 25676 25318 25317 29433 314850 89807 312664 363875 685269 170633 361679 288924 24553 25523 25525 312754 79114 170668 24329 293847 364052 305679 295347 114513 100909827 24446 316213 299147 246781 305203 56011 289080 29542 311406 360814 25622 498596 305539 25514 24669 83504 29434 296072 310533 362572 498576 302808 314596 24888 294515 60427 25193 170851 687346 60662 100361294 25267 59322 25022 29622 25266 59325 171337 29183 24629 24628 64363 309548 304893 24716 361171 170700 361601 64022 289625 25136 170818 171109 114486 60464 364686 301555 24605 289257 293621 305614 64159 24586 314251 81504 25614 24525 25150 313845 308458 50689 29431 29432 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10223201 Transport of organic anions 24221 170698 140915 58978 84511 140860 259248 432363 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%10225125 Protein localization 85239 84029 24792 680424 65183 116470 64461 24803 171374 64460 64667 25611 24686 24248 83519 685325 297570 363516 314304 29534 29533 54226 83842 83522 501072 65192 288584 171142 361413 64156 65030 266686 498332 50522 24479 308518 308718 361831 291075 114027 25700 63868 310682 503049 80881 311203 311446 192255 117265 297029 303272 282634 25541 100912032 24451 85255 311849 363445 309532 50559 116718 64001 291922 641452 293067 64526 307081 25437 25270 79244 81920 360463 305581 84356 50681 84114 312703 360826 84470 365571 293991 29725 298689 24599 114209 113956 58857 79238 65134 307170 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%10221905 DNA Replication Pre-Initiation 680498 365877 295596 299112 690795 312538 360908 316273 296178 313479 291927 307126 360621 304573 362607 24917 59102 29728 312046 298098 292071 301430 288532 287772 292766 313138 64156 296368 29669 29668 362385 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 310678 305420 361831 302783 366381 24829 292588 24828 81827 293155 83806 311078 192255 117056 301323 685909 100912032 680615 360643 85241 303175 64627 306970 306945 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-RNO-350054.1 Notch-HLH transcription pathway 297453 362981 689844 56761 310405 363287 679028 84578 84580 303101 301164 297893 406162 365755 302711 363481 303539 687001 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%10224049 IRAK2 mediated activation of TAK1 complex 313121 192255 64156 362418 311245 50522 100912032 308267 317546 RECYCLING PATHWAY OF L1%REACTOME%R-RNO-437239.1 Recycling pathway of L1 25751 116590 65046 116743 25416 140670 81521 83805 50687 83800 171574 84393 54319 54241 140694 116563 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism 301517 303879 83569 83724 362782 309527 300790 170698 140668 192242 58978 65192 25541 498790 307092 291283 361266 79244 171516 24186 307096 364773 498789 25429 191574 362360 298369 502348 24777 259221 29725 25428 296461 79111 25440 311129 246211 60351 303497 COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade 445269 155012 24233 406161 64459 298566 24854 24232 24237 29687 365466 114091 362634 25419 295703 64023 64668 54243 79126 117512 29333 312705 100360919 299606 192262 299928 289395 303861 113936 113959 84007 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223781 NoRC negatively regulates rRNA expression 680498 303175 365877 64627 306970 690795 310678 302783 24829 24828 117056 306945 685909 680615 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus 306808 50560 59268 171458 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-RNO-1660516.1 Synthesis of PIPs at the early endosome membrane 65052 310155 305419 288762 361632 363131 114554 307842 116699 309855 316457 80849 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 96%10224891 Protein lipoylation 29189 29611 299201 316342 305348 293453 365314 171133 81654 MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223413 MicroRNA (miRNA) biogenesis 311130 298533 299284 363006 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%10224331 IPs transport between nucleus and cytosol 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 294429 25497 287830 499974 291874 362281 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-RNO-69052.1 Switching of origins to a post-replicative state 295596 312538 316273 296178 313479 362485 291927 360621 29728 292071 301430 288532 287772 292766 313138 64156 296368 29669 29668 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 114494 287280 100912032 360643 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222291 Wax and plasmalogen biosynthesis 679520 84114 84470 302425 287380 293173 ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans 499271 24617 25567 29139 296456 29331 311061 25592 25393 81008 114122 170921 116640 685269 58968 24511 29302 FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222325 Fatty acids 24307 290623 266674 24894 24299 502969 298423 171522 24895 313375 286904 24306 299566 503122 54246 171178 50549 ARMS-MEDIATED ACTIVATION%REACTOME%R-RNO-170984.1 ARMS-mediated activation 59109 310738 295347 116478 54245 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190372.1 FGFR3c ligand binding and activation 29349 84489 25444 54250 25317 29369 29368 60464 170583 116499 60662 366061 66017 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%10224953 Retrograde transport at the Trans-Golgi-Network 314030 310411 367915 363123 84379 291990 296649 500249 362283 100361513 140673 29528 192152 690961 309798 65277 64187 286932 293344 685079 313493 25218 120097389 312689 25151 60562 364981 309922 117051 311919 293456 84589 361073 60355 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%10222121 Pyrophosphate hydrolysis 361663 310856 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%10224671 Phase 3 - rapid repolarisation 246150 171138 25470 63883 681190 367302 117018 84020 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224095 Inwardly rectifying K+ channels 116649 680149 83535 25560 50599 58979 29713 83633 29712 29718 25559 114117 116560 24400 25472 276720 81667 64199 79218 245986 60449 294962 81657 83579 25743 170847 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-RNO-5358493.1 Synthesis of diphthamide-EEF2 29565 362191 295394 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 24185 29498 25523 171128 24244 24600 29270 299331 29244 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines 363026 680498 301020 365877 310678 361402 290925 64646 83789 24828 444984 303518 502125 296732 89820 310769 680615 288563 361925 64627 295384 60421 306970 94201 83833 83712 361825 58919 297867 362093 THREONINE CATABOLISM%REACTOME%R-RNO-8849175.1 Threonine catabolism 25044 360816 65151 PHOSPHORYLATION OF EMI1%REACTOME%R-RNO-176417.1 Phosphorylation of Emi1 292263 25515 25203 54237 64515 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10225051 Regulation of Apoptosis 171116 298282 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223935 Activation of Na-permeable kainate receptors 54257 29559 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224455 Scavenging by Class A Receptors 54225 362862 25081 64202 25728 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9840310.1 Glycosphingolipid catabolism 294673 500961 316642 117185 363494 114104 303729 25524 25227 311013 316033 83537 303631 289687 94338 315222 24800 365619 310326 684536 362409 307404 312689 84431 300757 301525 OPSINS%REACTOME%R-RNO-419771.1 Opsins 192223 306307 310869 81644 498289 24717 89810 316259 CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization 81736 301334 24511 363509 304109 54281 363875 305679 64465 297893 500569 310678 302783 24829 24828 117056 100361294 685909 680615 303175 25697 64627 306970 25507 64315 689820 57341 26955 81650 266758 314641 360652 29144 362279 25066 361866 498515 306945 81717 116479 293860 310174 192248 85489 83501 680498 84430 304297 308417 365877 688673 116549 25724 362973 81634 362850 117048 362332 316639 690795 313806 60371 192183 360687 303068 25705 498281 301887 84407 170922 29181 307237 29460 497229 300445 300289 81918 293142 290270 361432 363058 25409 29606 24790 362650 78947 84006 309757 287772 29163 292766 29162 64156 293721 691517 29669 360882 29668 362040 83805 29425 100360846 29382 83712 117263 192275 25581 63879 29666 313048 100188932 303353 365388 686092 117262 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 29676 29675 84353 50522 81827 83806 311078 24514 192255 100912032 313474 292064 81679 25150 500870 50654 25751 311163 83502 25125 83427 24498 360820 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%10222743 Attachment of GPI anchor to uPAR 303277 353304 50692 295543 316400 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%10223321 Disassembly of the destruction complex and recruitment of AXIN to the membrane 299147 24881 117281 64512 315648 317674 291678 84353 113927 79257 501584 363193 312754 309179 303251 103691373 24673 303811 679110 24205 83721 84027 24672 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-RNO-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes 311860 680498 365877 140908 309001 690795 303539 309757 497991 497941 25664 619436 83516 310958 289881 291567 300367 293500 498112 300206 291440 313323 29417 24708 207118 306030 314964 299569 360581 83724 299607 287475 303403 299180 84578 311468 26295 362414 293488 317343 310678 310194 316209 315606 360642 302783 362224 24829 316328 24828 314704 85265 290939 100362634 299905 679693 117056 365755 685909 302711 680615 303175 64627 301164 306970 304794 290829 100359816 306945 362093 102550344 311575 COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis 298490 287711 360639 363069 296167 294088 360511 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%10222705 Amino Acid conjugation 293779 353317 246263 688536 361637 HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state 113927 287772 292766 304832 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 301555 29671 287643 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 289711 289712 304729 296532 25273 84399 84380 289180 364475 89830 361769 691171 50938 25238 690516 29499 140588 140589 311567 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%10222797 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 25622 64156 50522 293624 287545 448830 246294 364867 252961 363328 60350 29260 362788 192255 299827 292892 100912032 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%10223357 Regulation of pyruvate dehydrogenase (PDH) complex 81530 89813 681913 117098 246311 54705 289950 298942 296849 81654 311254 HEME DEGRADATION%REACTOME DATABASE ID RELEASE 96%10222691 Heme degradation 79239 292737 494500 58978 140860 24186 24861 312382 25303 24565 24451 24360 116599 ANDROGEN BIOSYNTHESIS%REACTOME%R-RNO-193048.1 Androgen biosynthesis 24470 682974 29632 305291 25146 64677 116700 24950 84013 25329 360348 117182 DNA REPLICATION%REACTOME DATABASE ID RELEASE 96%10221907 DNA Replication 303612 309441 292058 307639 499914 290842 85472 84490 310678 302783 24829 24828 117056 685909 680615 303175 64627 306970 306945 680498 365877 295596 299112 690795 312538 360908 316273 296178 313479 362485 291927 307126 360621 304573 362607 24917 59102 29728 312046 298098 292071 301430 288532 287772 292766 313138 64156 296368 29669 29668 362385 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 288003 114494 287280 361698 25737 301323 100912032 288414 360643 289758 116468 59294 89809 85241 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%10225089 Aryl hydrocarbon receptor signalling 301252 25242 25243 498999 362809 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222497 GPER1 signaling 29699 25521 24511 25725 24679 85385 293508 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 96%10225003 Interaction between PHLDA1 and AURKA CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%10224135 Cross-presentation of soluble exogenous antigens (endosomes) 287984 65138 94198 29673 29671 29670 29677 29676 29675 81827 83806 502852 311078 498011 295279 287772 292766 29669 29668 29425 100360846 117263 25581 29666 303353 365388 24968 117262 24967 85492 291983 29614 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%10223713 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 266607 25253 302813 25040 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis 26295 50522 60371 192255 287155 266610 246097 100912032 25385 690743 56816 501083 306886 64665 246756 246240 363836 117279 114562 83764 64156 83841 311567 64044 63879 299331 305549 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%10222885 IKK complex recruitment mediated by RIP1 306886 246240 641452 64156 116725 311245 50522 81920 309295 60371 361831 287545 448830 364867 363328 309361 60350 29260 192255 100912032 84351 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375276.1 Peptide ligand-binding receptors 379044 360579 25593 500157 171056 310327 78964 25723 25555 89808 29237 192205 29235 192206 24221 29234 84475 29471 54226 171044 102552838 360918 24797 685243 24677 25524 25087 294807 24323 24326 29335 301086 690158 24659 266997 24772 114105 60628 25504 445269 171371 497942 192648 192649 246358 114215 297025 25635 116637 25516 29310 301066 25726 287910 298006 362454 498335 117041 25616 366270 366274 29538 117029 245920 83518 24889 60665 78976 25298 54305 25706 259224 259222 24613 25380 25264 287730 24938 25107 363682 25108 29180 688605 378939 316019 29385 116677 246075 29636 282832 116498 25340 24182 50672 25033 25342 29191 29141 24180 287673 292409 499194 113959 64042 25245 246759 117518 29397 25007 260319 292419 58812 287561 287562 24604 81509 63850 63887 171104 83567 25569 297795 171101 29363 54258 84348 24232 305236 50577 289023 171551 24807 24806 24808 117549 295144 25570 81503 29256 362505 100360071 24179 497196 497078 25542 64636 57305 308163 25601 84007 117027 25605 60337 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 96%10224763 Phospholipase C-mediated cascade: FGFR1 29349 25444 25443 54250 25317 170700 83504 29368 170633 170583 25738 79114 116499 60662 170579 66017 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-RNO-975634.1 Retinoid metabolism and transport 292697 314941 54225 25056 55939 25080 25081 25592 498790 307092 24539 691984 171517 291283 24710 361266 25703 171516 24856 25702 307096 25680 364773 192259 498789 116673 191574 24771 299858 362558 300027 64047 317322 25236 296972 29216 25216 25649 315644 25615 25728 58920 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells 306636 287989 25150 686310 81751 312275 24338 304109 360546 81515 363875 83805 289231 300802 81687 81686 29192 292788 295378 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 96%10224413 MASTL Facilitates Mitotic Progression 60336 307169 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 96%10224333 Synthesis of IPs in the ER lumen 29688 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-RNO-918233.1 TRAF3-dependent IRF activation pathway 292892 293624 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway 84495 79116 29240 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 96%10225445 Cellular response to mitochondrial stress 54318 296302 307480 27137 298203 298282 114766 299027 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224695 DAG1 glycosylations 84430 293667 688673 313139 361368 316091 362567 306549 311202 291212 362520 299841 493574 257647 114489 308390 140568 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223677 Leukotriene receptors 114098 114099 767613 59264 170926 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%10224285 Cysteine formation from homocysteine 24250 24962 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223493 Integrin signaling 25614 171337 24185 313845 81745 685269 29434 83805 24697 25414 315707 59326 361714 24366 24367 295347 54245 85385 25155 81504 29302 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224989 Butyrophilin (BTN) family interactions 306956 302934 306957 684480 288375 497811 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%10225397 Regulation of CDH1 Expression and Function 85489 680498 84430 365877 688673 116549 690795 25705 300445 293142 290270 29606 78947 309757 287772 292766 64156 293721 54281 29669 29668 362040 83805 29425 100360846 83712 29382 117263 192275 25581 29666 313048 100188932 303353 365388 305679 117262 686092 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 297893 29676 500569 29675 84353 50522 310678 302783 24829 24828 81827 83806 311078 192255 117056 685909 100912032 680615 313474 292064 81679 25150 500870 303175 50654 25751 25697 311163 64627 83502 83427 306970 25507 689820 81650 266758 314641 29144 306945 81717 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%10223543 Degradation of the extracellular matrix 116510 100169747 306404 300341 408218 29139 117033 362347 25393 63849 29650 29175 25052 83685 308476 362701 58968 54281 81687 81686 25335 65164 315174 66015 65205 170808 299606 24291 83513 116694 57025 24691 29268 50654 29543 25697 306260 25627 685612 83502 117061 85253 499285 304608 290257 304802 63834 315388 29156 29155 29154 29153 25353 303000 683849 291848 304135 499431 300338 25246 81707 25403 25406 25481 24153 103690254 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 96%10222665 Eukaryotic Translation Elongation 300033 29565 293725 363241 171361 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-RNO-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK 24525 81646 313845 116590 25433 501560 50689 25706 81771 24680 25320 117269 24605 24329 293621 81504 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 292762 682390 298700 25348 691947 362952 81775 81776 299872 81773 81774 293427 288599 303831 299027 54318 65136 691531 27139 296302 288516 294282 122799 29236 681429 117053 100362640 64156 161477 292148 100361756 29288 29287 29286 29285 299899 124323 140654 171350 29304 140655 29284 300069 293484 103689992 122772 117045 29258 116636 83789 94266 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 96%10223969 Deubiquitination 311026 29560 360471 60331 363982 497672 24208 292876 64557 363084 298576 315523 56084 315911 360763 25490 315639 309153 25493 312688 290997 290631 316794 56816 306886 298534 24919 24842 29240 289468 24890 64646 362704 24828 25700 306257 502125 680615 363445 361925 301164 306970 365877 85471 60371 304798 303539 287772 292766 64156 29669 171102 29668 117273 79257 64515 29425 100360846 117263 25581 29666 54237 303353 116643 365388 117262 302415 85492 290864 286761 288306 24255 287984 29134 361190 65138 100361658 94198 684097 294790 140593 315723 29673 25387 29545 25388 295052 313427 29671 29591 50554 29670 361749 29677 308051 26295 50557 29676 362414 65137 29675 25631 50522 688466 310960 100360606 361831 304298 308896 100362121 171152 81827 83529 360990 83532 83531 293345 83806 302488 311078 291737 266601 192255 290652 114494 408217 24205 363164 361381 100912032 114558 298012 296084 115771 361495 85423 304150 310306 307905 498560 315134 24577 293494 296121 683630 500572 311245 498798 499801 309295 362636 360853 81516 314453 500133 297593 171565 84478 287362 25671 171329 312937 313121 29357 362788 287876 362491 311856 304017 293705 288482 304579 316440 311030 362258 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222381 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 24158 117543 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation 29349 83823 29610 25444 54250 25317 170700 29368 170583 79114 116499 60662 66017 SPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9845614.1 Sphingolipid catabolism 499210 313339 286896 301118 65183 246115 309147 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 25444 25443 54250 25622 83504 29368 170583 25513 25738 299236 24605 499308 60662 293621 170911 366205 170579 85385 66017 81504 29349 24525 313845 361388 170700 25317 314850 170633 79114 116499 316213 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223783 Negative epigenetic regulation of rRNA expression 680498 303175 365877 64627 309757 306970 690795 310678 302783 24829 24828 117056 306945 308911 302553 685909 680615 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181430.1 Norepinephrine Neurotransmitter Release Cycle 25558 25549 140592 84556 25012 116470 25531 24803 24904 25716 29503 64830 293645 64832 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%10222829 Toll Like Receptor TLR1:TLR2 Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 680127 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-RNO-5620920.1 Cargo trafficking to the periciliary membrane 29374 299246 114089 83567 362142 363272 79120 679894 305287 367714 299809 361930 117103 171044 25273 100910342 24818 64632 288305 294864 365770 316102 314961 24717 60627 295230 81830 171455 85258 24650 116654 252881 363760 50556 29885 363126 361789 113948 245709 64664 25411 309451 500832 315484 311456 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%10223909 Interleukin-2 family signaling 24918 25126 365769 690369 116558 25704 313050 25670 171081 50646 65038 116689 25513 25326 25746 116562 366508 116630 24514 54259 170911 60664 84477 85243 85385 25155 81504 313845 25125 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism 316559 305889 680668 303676 289175 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression 680498 365877 292778 288588 85471 316123 50662 690795 83503 361365 690966 117017 363633 498109 289561 192218 301128 311764 500633 299331 24919 363026 64466 304157 297893 500569 24890 310678 83828 302783 83830 24829 362110 24828 84424 362809 260321 117526 117056 25154 685909 680615 303175 64627 60349 60421 81647 301164 25098 306970 314322 171068 361391 301252 306945 24516 GASTRULATION%REACTOME DATABASE ID RELEASE 96%10225431 Gastrulation ALPK1 SIGNALING PATHWAY%REACTOME%R-RNO-9645460.1 ALPK1 signaling pathway 310877 313121 192255 64156 311245 50522 100912032 308267 317546 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling 288264 25622 64156 50522 24697 116689 312688 359726 120103159 298205 502959 192255 100361294 298210 24481 686326 24917 100912032 120103158 100911527 89829 690894 305896 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 680915 315344 79116 81528 170841 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-RNO-418990.1 Adherens junctions interactions 81736 301334 304109 54281 363875 305679 64465 297893 500569 310678 302783 24829 24828 117056 100361294 685909 680615 303175 25697 64627 306970 25507 689820 26955 81650 266758 314641 29144 25066 361866 498515 306945 81717 310174 192248 85489 83501 680498 84430 308417 365877 688673 116549 362850 117048 316639 690795 313806 60371 192183 360687 303068 25705 498281 301887 84407 29181 497229 300445 300289 293142 290270 361432 363058 25409 29606 24790 78947 309757 287772 29163 292766 29162 64156 293721 29669 360882 29668 362040 83805 29425 100360846 29382 83712 117263 192275 25581 63879 29666 313048 100188932 303353 365388 686092 117262 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 29676 29675 84353 50522 81827 83806 311078 24514 192255 100912032 313474 292064 81679 25150 500870 50654 25751 311163 83502 25125 83427 24498 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%10224241 Hydrolysis of LPC 297694 361401 311341 691905 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-8868773.1 rRNA processing in the nucleus and cytosol 83789 291317 291434 81729 25347 28298 313707 305258 360828 64205 26962 289809 313167 94266 310720 300092 100910714 363134 362967 64298 289810 290641 296865 192180 359727 303608 362214 360552 305076 314617 310019 315705 85432 366017 60373 361923 134480579 117042 102551819 287120 287122 291987 499782 294975 297685 64462 291061 140661 140662 29257 362902 25348 362229 300079 291996 292964 81775 293418 81776 317399 290660 81773 81768 81774 291071 100361974 314713 65136 362631 679140 691531 27139 360574 313744 58822 294282 360572 361262 122799 245981 29236 681429 497860 117053 81770 100362640 300045 64156 161477 308201 290556 64640 100361756 361159 29288 81764 29287 686999 29286 81765 29285 81766 114021 124323 140654 81767 81763 29304 140655 312706 300050 29284 690297 100361060 103689992 309301 58927 122772 29258 293828 292747 689284 288647 100360664 368084 316317 307850 29283 29282 296709 289740 64302 64306 314830 100360439 64307 50522 298065 314545 361452 134486107 362703 361977 363237 362426 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-RNO-3000471.1 Scavenging by Class B Receptors 54225 25073 25081 94195 117254 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation 246299 690254 685539 306012 304204 362537 306542 171068 83503 690966 301246 294687 498109 362095 117526 114205 316810 311487 310685 361102 685465 313914 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%10222485 Neurotransmitter receptors and postsynaptic signal transmission 680149 25302 79211 84420 66013 140675 58979 25023 363447 171571 24244 140729 25674 501560 84591 114117 24400 140724 64508 65187 170945 25050 192258 24397 29695 81667 29694 24681 84016 29699 24680 171503 553106 81664 191573 60341 116563 315840 25743 170847 116649 50599 29713 83633 29712 29718 116560 54257 29559 84347 140725 60355 65046 140670 64053 24409 24408 24410 25400 24245 24246 24412 24411 29629 29628 29627 83613 29495 50592 25252 171140 117284 58948 64199 286924 83506 24611 81646 79218 29709 29708 25103 81636 29707 245986 29705 29422 54239 60449 171131 24947 293508 81771 25753 302950 54240 117269 25590 81721 294962 79246 64532 58963 25521 65024 25686 298521 81657 25289 79557 24407 25643 24406 25725 25456 24922 24679 59317 83579 29241 25451 25450 ESR-MEDIATED SIGNALING%REACTOME%R-RNO-8939211.1 ESR-mediated signaling 116590 24244 25513 81664 170911 60664 85385 192218 65179 25433 25313 301128 311764 29149 500633 299331 24329 81687 81686 24919 170906 246332 363026 363425 64466 25335 361810 304157 297893 500569 24890 310678 25149 302783 24829 24828 362110 294515 25718 362809 260321 117056 25154 685909 680615 25522 59325 29183 24185 303175 25233 361967 64627 24600 60421 60349 301164 298184 306970 25098 64022 170897 171068 361391 306945 680498 365877 292778 288588 85471 29414 316123 50662 85252 690795 83503 361365 690966 117017 363633 498109 289561 83571 81745 83805 306792 83828 83830 84424 24605 293621 117526 286924 25614 24525 81646 50689 81647 314322 301252 25686 25643 24827 24516 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%10222221 Signaling by Insulin receptor 116590 25444 25443 54250 29369 29368 25513 170583 170582 297932 298103 246273 29516 29757 289407 170911 361992 84477 362802 170579 85243 368044 296981 85385 66017 298451 299971 29349 83615 29348 170667 84489 436582 498416 297566 312488 29376 117596 81745 361388 94170 24506 116664 24505 25317 366545 314850 360406 170633 79114 25622 83504 24697 25700 60662 25022 81504 25233 313845 50689 363131 170700 289625 65052 60464 25467 116499 25114 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling 83615 170667 436582 297566 312488 117596 94170 116664 366545 24825 499991 64678 170824 29199 288562 297932 298103 29757 289407 362802 368044 296981 298451 299971 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 96%10224861 Cargo concentration in the ER 290994 295461 246117 58842 690252 24648 300743 100912115 65165 25423 685144 29183 361705 301012 252929 171049 84599 683007 302470 287275 25407 116666 64154 289994 24827 287276 50592 58817 65134 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223825 Lysosome Vesicle Biogenesis 25387 24803 56084 299825 54226 25751 252929 116743 312689 83800 116561 85491 288785 54241 100362805 365191 366618 171575 83730 366311 64310 313409 304344 24468 310746 361459 306332 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%10224747 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 84495 367090 29240 81528 305957 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223775 Cation-coupled Chloride cotransporters 691209 29501 54300 308069 83629 171373 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223791 Type II Na+ Pi cotransporters 25548 246234 84395 HS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022928.1 HS-GAG biosynthesis 25592 303218 294449 302489 691984 293451 171517 292155 295430 84406 29633 363618 114002 116673 364476 24771 684979 108349781 299907 317322 25236 25216 25615 58920 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224411 Ubiquinol biosynthesis 308453 498909 304542 365592 360887 296128 498332 366013 299195 25249 313521 29309 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis 308100 309262 117278 114100 310645 83791 64191 81681 140910 78968 300095 89784 29580 291211 293688 29637 25675 81726 619549 298298 81727 29540 29230 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10224733 RHO GTPases regulate CFTR trafficking 24255 85428 NGF PROCESSING%REACTOME%R-RNO-167060.1 NGF processing 310738 54281 25507 116548 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-RNO-983169.1 Class I MHC mediated antigen processing & presentation 502852 498011 303024 287155 56816 287927 296456 363836 83730 89829 308669 641452 81920 311373 24812 293060 362277 361187 687633 315608 50558 192351 360534 316395 298689 317241 362294 315863 29274 305268 140939 303963 295252 316005 353227 314613 313525 305351 301674 303735 295704 363284 500017 64624 299197 498726 500262 117553 140941 308999 60383 64630 306417 289437 64631 155812 64517 362081 310363 313743 362511 498959 100360914 503446 29468 308283 302987 288596 304920 308968 293023 24223 287772 292766 64525 64156 287706 494223 296368 685029 29669 362087 29668 64515 499114 66021 29425 100360846 171043 619577 288921 361389 117263 688993 25581 313722 309591 367785 29666 363188 305792 303353 292757 365388 360926 117262 301515 316575 85492 290692 288671 683077 290875 282845 287984 312647 65138 361219 498005 94198 360818 294790 140593 361907 687364 29673 297930 302938 29671 685860 29670 309453 29677 690769 29676 171136 29675 500532 50522 680842 303478 305420 100909445 361831 306505 366381 94196 292588 500511 81827 362566 79129 414786 83806 306750 303689 311078 296988 192255 363790 287280 24750 361765 24874 652955 100912032 311866 360643 308901 25617 295279 303336 313264 297961 311881 301042 362900 300950 291597 689226 81807 117537 24974 361268 316614 303792 499400 300724 306825 300849 117524 300968 24988 313115 297592 362367 316628 499877 24968 300813 24967 291983 364681 25489 29614 313445 192256 365527 362377 362376 309758 362814 306129 366854 367167 81816 289508 313101 501546 314432 81815 171105 296161 500587 29528 100909827 297522 64202 311567 29144 361866 287276 313806 685144 287275 58817 93646 295461 301555 116725 690516 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%10222811 Creation of C4 and C2 activators 29687 114091 362634 25419 64023 64668 312705 64459 100360919 298566 192262 299928 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%10222927 p38MAPK events 24525 315994 24605 293621 29622 289014 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%10224233 Acyl chain remodelling of PG 311341 366196 289733 296048 361467 362039 691905 29354 29692 295631 298579 29526 29359 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%10222057 Neurotransmitter uptake and metabolism In glial cells 24957 29483 170567 29482 RHOT2 GTPASE CYCLE%REACTOME%R-RNO-9013419.1 RHOT2 GTPase cycle 287156 192647 171086 497974 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224697 DAG1 core M3 glycosylations 114489 84430 688673 316091 306549 291212 GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism 114508 25741 24651 362282 24334 25104 316265 315722 292804 25060 292138 24189 296973 289608 54283 25634 25438 685076 24385 66020 303565 100364027 24638 24959 294321 60416 498731 24191 24849 25059 294429 24640 24642 287830 25658 291874 29573 362281 117276 113975 24362 65152 292085 295692 117021 362335 24644 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 LANOSTEROL BIOSYNTHESIS%REACTOME%R-RNO-9969896.1 Lanosterol biosynthesis 308100 310645 83791 81681 89784 29580 291211 29637 25675 81726 619549 81727 29230 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%10224485 Activation of NIMA Kinases NEK9, NEK6, NEK7 299204 25515 25203 54237 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 96%10225447 Mitochondrial unfolded protein response (UPRmt) 24185 79245 294515 293615 24472 65028 24890 SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog 84420 64508 113927 29699 287772 292766 304832 289874 64156 29669 29668 29425 100360846 117263 25581 29666 303353 116643 365388 117262 85492 84027 287984 65138 362891 94198 29673 301555 303743 29671 287643 287612 29670 59320 29677 65209 29676 311324 29675 499241 50522 307724 361712 308577 100362124 305349 303968 81827 295654 116475 312651 83806 503018 311078 362265 192255 287280 361765 100912032 289711 289712 304729 296532 25273 84399 84380 289180 364475 89830 361769 81636 691171 50938 25238 690516 29499 140588 140589 293508 302950 311567 64532 25521 25289 25725 24679 25506 29241 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 96%10224001 Regulation of signaling by CBL 25734 25150 81515 25513 366508 287942 170911 60664 85243 54245 25155 500985 81504 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling 29613 81737 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA 365407 171365 314417 680737 299811 116697 304277 366468 289582 683927 681062 687711 689116 298075 100362099 681031 291877 311670 501688 311166 299256 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%10224669 Regulation of TLR by endogenous ligand 54225 295214 116547 353316 317468 310553 305354 448830 24366 94195 60350 24367 29260 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%10223029 Downstream signaling of activated FGFR2 25444 25443 54250 25622 29369 29368 170583 25513 25738 24605 60662 293621 170911 170579 25022 85385 66017 81504 29349 29348 24525 313845 361388 170700 25317 314850 170633 60464 116499 316213 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 59294 361698 59102 289758 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 96%10222629 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 114764 29564 117281 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 305270 83572 140734 681050 58945 684439 64515 297176 312754 114592 294429 287830 299147 292085 25515 24669 297522 81738 683983 315648 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363193 363028 309179 315164 24673 304951 289150 361416 363174 81655 303037 363059 24672 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225131 RHOA GTPase cycle 79239 306618 287537 287418 84009 120099896 310635 311647 310999 78966 117020 25513 301334 293024 362648 295378 83615 307098 64665 29528 114559 140898 361921 83764 304109 310192 64678 114513 25270 300115 303501 100363276 317598 296323 309696 297383 310833 360678 306183 78967 312113 29275 314249 312108 83620 54350 296060 308097 306357 65134 360942 307170 363031 688429 362456 361882 314618 305234 367085 300225 303611 314903 305367 54308 303222 498282 361940 60431 361029 171296 360509 291000 64630 290396 503306 366170 299012 64351 314212 29355 363213 293947 306279 246249 312640 29681 362893 679082 288093 307459 305156 306400 498130 310074 25537 296162 25096 310621 300030 117273 313618 361617 116666 81679 PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis 313786 24230 29189 29680 24192 25557 79122 291699 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%10222167 RNA Polymerase I Promoter Clearance 680498 365877 84389 288651 361580 502227 294693 690795 83503 690966 291703 498109 83712 100362346 304714 313048 117535 361784 360893 361420 290669 362834 64520 313245 680493 306274 362728 83582 690450 83581 310614 361724 297093 25574 297893 310678 302783 24829 24828 301246 117526 117056 685909 680615 303175 64627 50689 306970 266713 306945 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes 117281 114495 295704 312688 25738 309361 313017 64511 25318 54281 312754 54237 24468 24842 24472 300955 362678 117063 314172 362050 24667 54287 306231 691105 84472 171164 304859 63880 359726 499155 81746 298693 81635 304266 306204 304545 291978 24649 114558 29219 25498 24963 501552 81822 315648 502320 60460 303742 25125 50689 116725 170897 309295 24673 287876 311130 292892 311430 363006 84351 25489 24672 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%10224985 Synaptic adhesion-like molecules 58948 64665 25529 308495 688721 83764 365222 360406 140945 24409 24408 24410 24412 24411 29629 29628 29495 50592 25252 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 287984 65138 94198 294790 25515 29673 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 100912032 360643 287772 292766 64156 296368 29669 29668 64515 29425 100360846 361389 117263 25581 114592 29666 303353 365388 64193 117262 85492 288671 290875 24708 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression 361923 134480579 117042 287122 499782 140661 292762 140662 682390 29257 298700 25348 691947 300079 362952 292964 81775 293418 81776 299872 81773 81768 81774 293427 100361974 288599 303831 299027 362631 54318 65136 691531 27139 296302 288516 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 292148 64640 100361756 29288 81764 29287 29286 81765 29285 81766 299899 124323 81767 140654 81763 171350 29304 140655 29284 300069 100361060 293484 103689992 58927 122772 117045 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 83789 291434 81729 25347 28298 64205 26962 94266 100910714 64298 290641 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 287984 29560 65138 94198 29673 29671 29670 29677 29676 29675 50522 361831 81827 85265 83806 311078 192255 24874 100912032 641452 287772 292766 81807 64525 64156 316101 29669 64345 29668 29452 81920 54702 29425 308457 100360846 117263 25581 29666 303353 365388 117262 85492 PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism 311422 290029 361068 171047 100363253 361274 287406 305149 313574 117260 497811 298881 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224205 GRB7 events in ERBB2 signaling 432361 29496 84427 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224361 DS-GAG biosynthesis 50568 25181 29139 25393 114122 81651 286974 361450 365583 297865 CS DS DEGRADATION%REACTOME%R-RNO-2024101.1 CS DS degradation 25227 50568 316033 25181 300993 404783 367166 29139 24434 363513 25393 294673 114122 500961 81651 300757 301525 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 96%10223159 Sterols are 12-hydroxylated by CYP8B1 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%10224519 SUMOylation of nuclear envelope proteins 25573 301442 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 96%10224907 TP53 Regulates Transcription of Death Receptors and Ligands 24484 308986 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224779 FGFRL1 modulation of FGFR1 signaling 29349 25443 54250 305539 360903 29369 29368 296072 170633 170583 116499 60662 170579 FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling 64044 266610 246097 25385 HDL REMODELING%REACTOME DATABASE ID RELEASE 96%10223449 HDL remodeling 292697 25081 291437 24530 24186 25728 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223717 Trafficking of AMPA receptors 25023 363447 171571 140729 84591 140724 24681 84016 24680 65046 140670 25400 24245 24246 116563 84347 315840 29629 29628 29627 140725 29495 50592 59317 60355 25252 171140 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-194313.1 VEGF ligand-receptor interactions 89811 25589 360457 94203 83785 114110 114111 INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling 315599 500900 113894 309157 114495 116596 362418 308267 291861 317546 81736 25493 312688 25466 301059 117022 54226 24493 309361 300177 361677 303024 303604 314870 60582 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 287280 361765 100912032 25742 116725 311245 309452 309295 310877 363520 291921 64044 313121 287707 84351 305549 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%10225033 TFAP2 (AP-2) family regulates transcription of cell cycle factors 24577 304809 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223523 Neurofascin interactions 83841 116690 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%10224457 Condensation of Prometaphase Chromosomes 362438 81650 116549 305392 680089 362519 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-RNO-350562.1 Regulation of ornithine decarboxylase (ODC) 287984 65138 94198 29673 29671 29670 29677 29676 29675 81827 83806 311078 689588 25502 24314 24609 287772 292766 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222599 Activation of BMF and translocation to mitochondria 140734 246142 116554 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224075 Termination of O-glycan biosynthesis 29758 303692 690914 25197 362924 497227 309114 363040 64442 64445 RHOV GTPASE CYCLE%REACTOME%R-RNO-9013424.1 RHOV GTPase cycle 64465 300955 171296 25513 306417 305614 309168 64159 363445 83709 316369 114559 310074 301007 311721 307016 292756 304007 366492 24852 304546 315686 171581 54241 305645 140922 29431 362279 29432 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-RNO-1247673.1 Erythrocytes take up oxygen and release carbon dioxide 25240 54231 29242 310218 24440 360504 65207 24779 METABOLISM OF RNA%REACTOME%R-RNO-8953854.1 Metabolism of RNA 315170 288701 296320 501582 362153 363005 296219 114612 288718 500242 192246 308650 307446 100125373 363151 305479 140931 307410 171552 303057 498171 499020 287522 287768 29497 299620 295270 79426 365215 29344 366693 363064 294595 294232 687575 305586 295334 292067 24185 501285 362098 498251 363082 259170 79227 29578 360803 307503 81781 307947 313030 313035 298342 501621 94266 292810 64200 24420 290519 25578 499314 287596 287113 361808 100910202 500305 313131 317612 314336 500790 691397 366276 266605 500538 298385 305884 360726 361814 303346 287530 366163 287415 297455 85252 245976 297695 313588 360972 360855 360629 295284 301226 245957 302557 25348 362819 313450 81775 313449 81776 305714 686980 81773 80846 81774 313583 314313 360760 684558 303831 65136 361859 361736 691531 290614 27139 58822 300032 294282 288661 313433 122799 29236 313308 300361 681429 292535 117053 100362640 294711 161477 293862 100361269 100361756 312474 29288 361990 29287 302670 29286 303607 29285 85434 60376 124323 301432 140654 361887 171350 688288 140655 498600 29284 293408 302855 290666 103689992 289315 64510 122772 29258 89819 361542 362990 314836 84486 292729 361788 300687 300208 501926 368070 117259 363854 291534 500988 497967 361201 361449 498934 302969 494445 89827 300996 29667 294783 79256 361109 292019 170956 83624 362687 310687 364624 319110 291295 117280 117282 295428 246216 291060 689890 362361 361271 309651 25383 681062 307474 59087 84401 690585 170912 691538 361399 680891 361035 311855 367930 290284 362260 690303 300944 362394 362152 25379 679890 170933 306137 319113 294429 291794 287830 291874 362281 113975 685068 499391 292085 295692 84404 117021 362335 687711 363462 366016 58958 65160 691231 362557 65274 113929 100362099 64301 297522 245922 681031 81738 362688 683983 53372 316108 25497 310769 499974 84473 312947 171365 680737 291317 291434 81729 25347 28298 313707 305258 360828 64205 26962 289809 313167 310720 300092 100910714 363134 362967 64298 289810 290641 296865 192180 359727 303608 362214 360552 305076 314617 310019 315705 85432 366017 292778 60373 361923 288651 134480579 288588 361580 117042 316123 102551819 287120 689116 502227 287122 291987 294693 499782 83503 294975 297685 298075 64462 361365 291061 690966 140661 140662 117017 29257 362902 291703 362229 300079 363633 498109 291996 292964 289561 293418 317399 290660 81768 291071 100361974 314713 362631 679140 360574 313744 360572 361262 245981 497860 81770 300045 308201 290556 64640 361159 81764 686999 81765 81766 114021 81767 81763 312706 300050 690297 100361060 309301 58927 293828 292747 689284 288647 100360664 368084 316317 307850 29283 29282 296709 289740 64302 64306 314830 100360439 64307 298065 314545 361452 134486107 362703 361977 363237 362426 81635 25367 24468 308968 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 24668 24672 25594 117281 170538 24680 56011 24472 83789 291877 311670 501688 311166 299256 365407 314417 299811 116697 304277 366468 289582 683927 266713 84389 117104 29304 117045 304859 289014 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-RNO-9959399.1 SLC-mediated transport of oligopeptides 287478 246239 246280 117261 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-RNO-5626467.1 RHO GTPases activate IQGAPs 64465 83502 24244 65201 310621 84353 363875 29417 100360623 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine 363109 297393 498272 297417 498486 360518 302972 81759 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion 301226 498251 25383 170912 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%10222349 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 24158 171155 170670 140547 113965 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%10222251 mRNA Splicing 24468 291794 288701 296320 362153 363005 114612 288718 500242 192246 308650 687711 363151 305479 140931 307410 171552 303057 498171 100362099 287768 29497 681031 299620 295270 294232 171365 295334 680737 501285 363082 259170 29578 360803 81781 298342 292810 64200 287113 100910202 314336 500790 366276 500538 298385 305884 292778 361814 303346 288588 287530 316123 366163 287415 689116 245976 83503 297695 313588 298075 361365 690966 295284 117017 245957 302557 363633 498109 313450 289561 313449 686980 80846 313583 314313 361859 290614 313433 300361 292535 294711 293862 100361269 312474 302670 303607 85434 60376 301432 361887 688288 498600 302855 289315 64510 89819 362990 84486 300687 300208 501926 368070 117259 497967 361449 302969 494445 29667 294783 79256 292019 83624 362687 310687 319110 291295 117280 117282 246216 291060 689890 362361 309651 84401 690585 691538 680891 311855 367930 290284 362260 690303 362394 362152 679890 170933 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-RNO-9609523.1 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 64001 65183 116470 24803 64667 25437 24686 54226 80881 298689 58857 24451 65134 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%10222237 RNA Polymerase I Transcription Termination 362728 83582 690450 83581 288651 84389 361580 25574 502227 266713 294693 83503 690966 291703 301246 498109 361784 117526 360893 361420 313245 680493 REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs 287984 65138 94198 301555 29673 360814 29671 29670 305539 29677 29676 29675 50522 296072 24592 81827 314596 83806 311078 24605 192255 293621 100912032 29372 24525 304893 25676 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 25597 100909827 192126 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-RNO-191650.1 Regulation of gap junction activity 24392 292994 83805 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-RNO-5357956.1 TNFR1-induced NF-kappa-B signaling pathway 115771 306886 246756 83427 24835 25625 308267 688466 81859 687813 309295 60371 317546 498803 114210 246294 364386 60383 63879 309361 313121 312937 84351 290864 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 498790 58962 307092 291283 29527 361266 171516 307096 364773 498789 24886 191574 25527 25526 59103 362809 29224 CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation 114764 117281 83836 299850 64462 311191 692032 64158 311573 309098 311802 311529 290626 300963 315423 83572 171566 362203 683722 29479 58822 363055 58945 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 56010 316531 296554 287929 310344 680991 314787 60347 246150 29214 54237 299331 500069 362980 29167 29213 81740 192228 307347 305882 294010 25515 29753 29489 24679 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins 171337 25414 25614 24366 24367 295347 685269 54245 83805 29302 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 96%10224437 Phosphate bond hydrolysis by NUDT proteins 361068 361274 287406 305149 117260 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-RNO-187577.1 SCF(Skp2)-mediated degradation of p27 p21 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 29675 50522 81827 83806 362485 311078 192255 114494 287280 100912032 83571 287772 366275 292766 64156 94201 29669 29668 29425 100360846 499655 117263 25581 29666 58919 303353 365388 117262 85492 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 96%10225453 Signaling by LTK 303882 25513 313845 25467 170911 85243 85385 100910984 679566 81504 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA 24468 315170 288701 296320 362153 363005 296219 114612 288718 500242 192246 308650 363151 305479 140931 307410 171552 303057 498171 499020 287768 29497 299620 295270 366693 294232 687575 305586 295334 501285 362098 363082 259170 79227 29578 360803 81781 313030 313035 298342 501621 292810 64200 290519 499314 287113 361808 100910202 317612 314336 500790 366276 500538 298385 305884 360726 361814 303346 287530 366163 287415 245976 297695 313588 360972 295284 245957 302557 362819 313450 313449 305714 686980 80846 313583 314313 361859 290614 313433 313308 308968 300361 292535 294711 64156 293862 100361269 312474 361990 302670 303607 85434 60376 301432 361887 688288 498600 302855 290666 289315 64510 89819 361542 362990 84486 292729 361788 300687 300208 501926 368070 117259 497967 361449 50522 302969 494445 89827 300996 29667 294783 79256 292019 83624 192255 362687 310687 319110 100912032 291295 117280 117282 295428 246216 291060 689890 362361 309651 681062 307474 59087 84401 690585 691538 24668 680891 361035 311855 367930 290284 362260 690303 362394 362152 679890 170933 25594 294429 291794 287830 291874 362281 113975 292085 295692 117021 362335 687711 366016 58958 362557 65274 113929 100362099 297522 245922 681031 81738 683983 53372 291877 25497 311670 499974 311166 299256 171365 365407 680737 314417 299811 116697 304277 289582 683927 292778 288588 316123 689116 83503 298075 361365 690966 117017 363633 498109 289561 117045 304859 VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly 25292 54225 680551 310900 25506 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10223353 NOSIP mediated eNOS trafficking 292894 24600 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%10221921 Activation of the pre-replicative complex 312046 298098 85241 292071 301430 288532 313138 295596 299112 312538 362385 360908 316273 296178 313479 291927 307126 360621 304573 301323 59102 29728 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 96%10224895 TP53 Regulates Transcription of DNA Repair Genes 304758 362479 292778 84389 192350 288651 288588 500715 361580 683469 316123 81785 306998 502227 294693 83503 311796 361365 690966 362110 117017 305455 679203 291703 363633 498109 289561 81807 64525 266713 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%10224085 Factors involved in megakaryocyte development and platelet production 680498 85471 29699 360509 192647 363875 84393 29300 64633 64465 691504 297893 300158 500569 316226 64516 310678 293692 26956 89817 361308 363288 366998 289168 171291 113886 293502 315740 24514 366608 117056 85248 313438 192249 171041 366960 499951 171120 361512 500709 305987 114203 315992 312562 313254 25172 353302 287624 294286 246209 54254 314930 300266 303575 293508 64188 303659 314473 289309 117548 102554884 25521 313388 117550 171549 114124 362825 314906 25725 309523 25159 24679 289397 HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%10222561 Hemostasis 83785 114111 89811 360457 54226 81809 24511 59086 29302 25717 296456 691984 171517 116673 24771 362558 317322 25236 25216 25615 58920 64633 24697 25414 59326 361714 24185 84590 85253 287624 25578 300338 25246 25406 24153 116510 81745 81515 117273 83805 25387 25388 313050 24703 24514 29665 116689 25513 25738 54259 170911 60664 85243 85385 298947 497931 363875 316531 300158 500569 316226 64516 293692 26956 89817 361308 363288 366998 289168 171291 113886 293502 315740 366608 85248 313438 192249 171041 366960 499951 171120 361512 500709 305987 114203 315992 24600 312562 313254 353302 294286 246209 54254 314930 300266 303575 24186 64188 303659 314473 289309 117548 102554884 313388 29409 117550 171549 114124 362825 314906 309523 289397 24936 309609 80878 81613 140914 54225 24946 140928 24944 25081 58844 305021 54248 56782 361196 308899 54249 363015 315272 113995 24648 81749 29364 29243 500152 688705 29366 100359512 65037 498299 81739 445442 24816 81743 29254 686539 308637 308875 308995 116601 116726 116727 29583 29340 81778 116498 291085 54286 29599 29598 29476 65051 363195 81678 191569 306761 305795 29337 302470 29693 79224 307986 360922 25505 25518 24786 116635 89843 54404 312159 360950 140656 307811 171154 292661 306608 360606 65200 296488 24614 81803 81804 171577 56611 29186 502858 54320 64373 301229 296269 245955 315989 315509 304983 64025 114115 245962 500336 81814 684555 81821 116662 140866 100361138 140594 25599 29715 309186 681544 84551 50567 293628 363930 83580 619374 63885 24598 50693 314615 25441 682967 293886 24483 25692 24482 94168 289316 25666 25544 304917 287876 60395 304805 308291 25679 497978 89805 25673 140447 140448 499913 25528 24795 25023 114095 24791 301512 311795 313611 25651 25650 84491 300519 83509 307396 50719 29436 81683 497932 246328 303634 25041 299909 29659 309684 360918 309207 499099 25268 170924 25027 25262 295378 260320 63836 25524 362248 60327 25391 60325 25390 289055 293676 25087 294643 29600 363104 113947 24825 691992 25259 25373 364206 64465 246358 24599 24174 25265 29636 64803 50687 84393 24854 295703 79113 100360919 64199 25155 286924 315648 79218 245986 60449 293508 363193 294962 309179 25521 25686 24673 25643 25725 24679 83579 24672 680149 499271 24617 117281 58979 116590 25592 24244 170538 81511 114117 24400 81666 81667 24681 29699 315707 24680 81662 81664 24366 29691 24367 192647 54245 25313 24189 89807 685269 25523 25083 312754 24175 305679 29300 295347 24446 299147 25622 691504 297893 310678 29434 117056 25266 171337 24628 25172 116479 25159 293860 360942 680498 85471 81634 360509 50692 24605 293621 81504 25614 24525 25150 313845 50689 171115 84427 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%10223601 Regulation of IGF Activity by IGFBP 24484 114122 116640 84491 29237 170583 54226 24367 25268 83727 59107 192152 25087 24825 25373 292485 24259 296290 83476 140638 308807 303635 288038 289525 63878 25236 680692 313954 81686 89842 304334 362859 25685 362182 25615 25285 79438 24594 24765 689404 367252 79210 25307 303743 114031 29461 25662 503164 292848 25434 361676 25277 84595 680415 363455 360622 315111 338474 25641 286906 298683 79110 298296 60333 292905 29160 56646 25376 85253 24186 25353 300338 25649 25506 25728 116510 83501 54225 25081 29650 24648 361029 300445 691517 683007 79224 116635 29417 171154 24233 406161 24232 63880 362862 290257 266704 24483 24498 24482 94168 304917 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%10224661 ATP-dependent chromatin remodelers 680498 301020 365877 690795 245957 313583 290614 25573 304832 100361269 301442 303607 83712 100362346 313048 117535 65027 290669 291794 362834 64520 84486 300837 310614 192246 361724 297093 687711 81785 297893 305479 84353 310678 302783 24829 100362099 24828 303518 287768 296732 681031 299620 292019 295270 117056 363064 685909 680615 291295 312974 311607 171365 303511 680737 361925 293184 303175 307362 305501 293038 64627 308738 83726 100359714 84401 50659 300389 306970 360609 81781 291940 680891 64622 113984 83833 406195 361531 303060 103690021 292404 360804 293514 361825 301235 368001 292622 287876 299186 306945 361374 297867 361295 305589 192352 362093 361711 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%10222681 Cytosolic sulfonation of small molecules 83783 171072 292915 24902 24912 300983 64473 64305 288617 297433 360268 361510 503103 58953 312952 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223547 NCAM1 interactions 116696 117523 290905 306628 24586 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-RNO-1638091.1 Heparan sulfate heparin (HS-GAG) metabolism 688293 64537 360630 25592 368128 363513 303218 294449 302489 293451 292155 295430 84406 29633 363618 114002 364476 684979 108349781 299907 25697 691984 171517 116673 24771 317322 25236 25216 25615 58920 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 96%10225047 MET activates PTPN11 24553 361388 25622 24446 81504 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%10225353 Inactivation of CSF3 (G-CSF) signaling 25734 641452 81807 64525 64156 64624 81515 50522 81920 361831 24514 192255 100361294 100912032 89829 25155 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222475 DAG and IP3 signaling 83506 84420 29340 24244 170538 81636 64508 25238 81742 25050 24681 293508 29699 302950 24680 64532 60341 25521 29691 25289 25725 24679 29241 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10222835 MyD88 cascade initiated on plasma membrane 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 INTERCONVERSION OF POLYAMINES%REACTOME%R-RNO-351200.1 Interconversion of polyamines 308652 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%10222245 Signaling by Rho GTPases 79239 24511 64665 114562 83764 301007 311721 307016 292756 304007 366492 304546 315686 171581 305645 140922 114612 29753 306464 679342 287624 291441 257649 29448 257644 64041 25448 94266 29489 363028 25576 25578 315164 25577 304951 289150 361416 363174 81655 303037 307511 363059 114764 29564 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 313017 65201 681185 363235 308443 296137 24264 317252 305270 83572 140734 681050 58945 684439 81745 117273 302855 29495 29417 24255 117259 84353 313050 303251 303811 83721 81679 83502 498798 301252 311030 100360623 24208 56084 25513 170911 60664 83709 316369 114559 29433 363875 299331 294429 287830 292085 299809 500569 316226 50646 297522 81738 683983 366608 313438 171041 25522 305987 315992 317598 360678 313388 117550 171549 314906 54350 65134 64351 308875 503165 116666 64373 94195 287876 306618 66013 25023 287537 287418 84009 120099896 310635 311647 310999 78966 117020 309653 303634 301334 363460 293024 100362710 362648 295378 298404 83615 310460 307098 246174 363509 140898 361921 304109 310192 687105 29491 64678 170824 24392 54241 315840 309175 313838 64465 363445 25437 25270 85428 307170 65183 363009 81732 308761 304282 29146 287746 307562 500246 56785 64160 83809 259242 299857 64630 289820 306417 498174 308509 192348 309722 679934 293497 81531 305457 315265 116717 500287 192207 365355 305341 297518 360915 308968 685357 79115 315348 297406 295588 315121 29579 25097 288669 64515 66021 306506 312077 306871 297176 84031 117955 300067 114592 300186 360849 498331 313024 360840 303583 367235 361813 305605 117538 192277 117542 360854 303553 83724 287543 25515 310090 116685 498547 360500 304530 303888 114004 81824 116670 362938 303653 81818 114116 58823 313216 114243 54227 79129 500929 315732 305938 63994 362842 25230 690130 304813 291694 310013 60377 315829 300111 362988 315648 302976 291755 291999 311450 298144 25306 363131 89816 362993 81522 246314 312667 311793 308021 360596 65052 289229 64303 363193 299145 309362 29611 84014 309179 295635 678766 24673 286928 307035 261736 79249 317296 294568 689997 367902 24672 367901 25594 292279 688319 117281 313934 117039 116590 300838 29745 24244 310519 170538 113960 306152 83425 84510 501099 25488 308666 306004 362271 315707 682937 24680 309168 116478 29528 314850 312754 114513 362859 316213 299147 56011 24669 310678 302783 24829 24828 117056 685909 680615 365407 303175 64627 304893 116547 306970 300115 303501 100363276 296323 309696 297383 310833 306183 78967 362279 312113 29275 314249 306945 312108 83620 296060 293860 308097 306357 360942 363031 311860 680498 688429 362456 361882 314618 365877 305234 367085 300225 81634 303611 314903 305367 54308 316639 303222 690795 498282 361940 60431 361029 171296 360509 291000 290396 503306 366170 299012 314212 29355 363213 293947 306279 246249 312640 29681 362893 679082 288093 307459 305156 306400 498130 310074 25537 296162 25096 310621 300030 313618 361617 56010 116643 308869 301555 300955 305614 64159 81504 25614 81822 313845 50689 288057 24852 29431 171115 29432 84427 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors 499330 316062 25668 24778 299857 306262 361300 29142 50671 171053 367323 85496 499328 64392 293504 300886 297508 300328 25104 353255 64845 313241 313520 29319 361751 311536 25035 361472 687008 25551 100125370 361836 289095 170551 288240 301221 64533 293154 29723 24312 81506 314459 361884 362134 299699 29216 83578 291939 680308 303333 362657 751787 64300 315085 295229 294972 25732 298653 80848 363118 305248 50622 54349 60581 50621 365699 316559 362942 305889 680668 303676 289175 298490 287711 360639 363069 296167 294088 360511 309465 64001 81522 290947 24565 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10224073 Prolactin receptor signaling 89817 24391 24683 25235 24684 24514 287280 361765 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224711 Anchoring of the basal body to the plasma membrane 114764 117281 83836 299850 64462 311191 64158 311573 308443 311802 311529 290626 300963 315423 83572 683722 29479 58822 363055 58945 305467 366403 367153 360672 308064 252921 304007 293844 100362495 56010 316531 296554 310344 314787 60347 246150 29214 54237 299331 500069 29167 29213 81740 192228 307347 305882 294010 25515 287612 117103 307724 689779 366872 308923 680407 287383 300880 303915 293148 296136 313170 287836 117515 361727 266809 29753 309486 81830 29489 29885 24679 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 96%10224495 SUMO is proteolytically processed 103689978 78973 690244 690251 301442 499417 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides 498659 641658 498658 301034 316010 286995 613220 362347 613223 613224 286958 25052 613225 296354 641627 311558 50585 83687 305842 170496 641624 308873 290856 29692 296290 24854 24932 94195 299606 24691 24618 296321 116547 499925 290257 499926 310553 641632 314615 641636 305354 641651 641650 24620 246238 24941 299567 171162 683849 641644 84355 685161 100361909 308163 310611 316519 641652 641655 84387 641657 103690254 641656 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223955 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 25753 54240 25590 25103 29422 54239 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%10222003 Gluconeogenesis 362282 24362 24334 25104 316265 292804 292138 24644 24189 25634 25438 66020 303565 24959 294321 498731 24191 24849 24642 114508 29573 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells 287984 65138 94198 25023 29673 29671 29670 29677 29676 29675 50522 81736 25493 81827 316241 309361 83806 83477 311078 307366 303024 192255 305584 287280 361765 100912032 287772 292766 64156 29669 29668 309295 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84351 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10221993 G2 M DNA damage checkpoint 290805 308755 497672 64557 363924 303194 315969 290997 64046 290631 313017 316794 85482 308937 59102 192218 114212 287927 685055 310034 361815 306734 305000 300711 56010 690043 297627 54237 296099 360588 497856 64012 294800 24842 56011 498411 308669 295052 291787 289468 100361529 140583 362827 24829 362704 25203 288003 114494 288414 116468 303175 29753 64627 116725 25576 25578 25577 306945 307511 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%10223025 SHC1 events in EGFR signaling 24525 29183 313845 25433 25313 64022 24605 24329 293621 24827 85385 81504 59325 PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism 266607 25253 302813 83711 294075 24504 25196 301265 293142 25608 306515 25204 29200 59301 294698 64549 299903 64632 24506 24505 25653 60627 171455 116654 252881 50556 245709 25447 305287 171101 116700 25329 24391 113902 24715 302668 25627 113936 252929 302526 290257 24179 24310 64017 25040 266704 54242 24590 24482 266758 25506 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%10224507 SUMO E3 ligases SUMOylate target proteins 308755 497672 24208 25493 297561 25573 301442 499417 690043 24705 296099 294429 287830 58851 291874 362281 113975 292085 25591 295692 308669 117021 362335 304157 297893 366016 58958 24890 307151 362557 65274 362827 113929 297522 245922 81738 313038 683983 25154 53372 309626 25497 499974 310258 303730 25094 64627 690244 60349 64041 501403 60373 500545 363287 290744 64550 24413 25747 313304 361100 299957 367846 63996 313961 300772 29382 691688 24873 291171 117287 114592 313128 363269 361645 293528 102551929 315133 83826 501145 116698 64520 60351 300320 303310 287662 310375 83422 688041 25672 316164 83614 84385 293967 81812 24874 25737 117282 25498 309452 309295 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%10223257 Signalling to ERK5 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%10222887 TICAM1-dependent activation of IRF3 IRF7 292892 293624 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME%R-RNO-400206.1 Regulation of lipid metabolism by PPARalpha 363026 497991 83724 296732 84578 25747 365755 302711 24360 312947 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription 310091 298514 362045 64226 688041 310614 297960 361724 294924 315093 297893 686412 307151 313038 309626 310258 303730 315136 83712 295357 100362346 313048 117535 26954 117044 117043 290669 56718 362834 360776 64520 308869 501403 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223637 Glyoxylate metabolism and glycine degradation 114027 24792 299201 360975 311446 171133 83784 298942 25134 685325 25721 306586 NUCLEAR RNA DECAY%REACTOME%R-RNO-9930044.1 Nuclear RNA decay 292067 679140 307850 116697 300032 366017 288661 307446 300045 689116 313707 294975 686999 298075 289810 170956 686980 306137 314836 305586 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 96%10223031 Signaling by FGFR2 499349 117281 116590 292778 25444 25443 288588 54250 316123 689116 29369 83503 29368 298075 361365 690966 25513 117017 170583 25738 363633 498109 289561 170911 170579 85385 66017 29349 29348 361388 25317 64156 314850 170633 83805 500985 316213 25622 50522 140931 500409 500526 306141 362950 307810 29497 361655 24605 192255 60662 293621 25022 100912032 81504 24525 313845 50689 29578 170700 114486 60464 64200 116499 24673 64535 24672 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%10225269 Activated NTRK3 signals through PI3K 29613 81737 83805 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9034793.1 Activated NTRK3 signals through PLCG1 25738 29613 81737 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10222989 Sulfur amino acid metabolism 367181 83586 170943 25274 192172 365972 309732 305177 25331 81522 24250 24962 29443 290947 292710 298934 81508 81805 288912 25256 298227 81718 691966 79462 ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%10224873 ERBB2 Regulates Cell Motility 25433 25313 24329 432361 498596 298787 29496 64022 117273 59325 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 96%10222337 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 25287 171155 170670 140547 113965 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-RNO-69615.1 G1 S DNA Damage Checkpoints 113927 362485 304798 303024 360860 114212 58936 58822 83571 287772 292766 64156 29669 171102 29668 300711 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 24842 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 140583 81827 83806 311078 192255 114494 287280 361765 100912032 685474 311575 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-RNO-9006925.1 Intracellular signaling by second messengers 497932 25466 301059 309361 246273 300177 361992 287155 84482 24855 24185 25233 29414 81745 287772 292766 64156 29669 29668 83805 29425 100360846 117263 25581 63879 29666 303353 365388 117262 302415 85492 287984 65138 94198 29673 29671 29670 309419 361749 308051 29677 50557 29676 29675 50522 313050 81827 83806 311078 296988 192255 100912032 83506 315648 310306 291999 81636 25238 500572 293508 302950 363193 25467 64532 309179 25521 116499 432361 24673 25289 64030 24827 25114 25725 24679 25489 29241 24672 362045 84420 360471 117281 116590 25444 25443 24244 54250 170538 64508 81742 29369 25050 29368 24681 29699 24680 170583 25513 170582 60341 29691 366508 29496 170911 60664 170579 84477 85243 66017 29349 29348 84489 25433 29376 25313 361388 298947 25317 314850 497931 363875 170633 29149 24553 312754 79114 24329 24446 299147 25622 498596 297893 24890 83504 25149 307151 294515 60427 313038 60662 29613 309626 81737 25267 25022 25266 59325 310258 29183 24629 303730 24628 170700 64022 289625 315136 60464 81650 314641 501403 116549 308875 29340 83571 24506 24505 83712 292887 291171 295357 100362346 313048 26954 117535 117044 117043 290669 362834 56718 360776 64520 308869 310091 298514 64226 688041 297960 310614 361724 294924 315093 686412 81504 25150 81646 50689 315189 313558 59265 311245 294048 296648 116723 25660 89812 294235 25556 24225 363520 310131 79209 25408 64545 361696 79240 56822 25730 25054 58918 365865 140607 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10222569 Integrin cell surface interactions 64350 499271 298702 25304 360606 310683 25361 25464 83577 313785 25713 54266 170921 360647 116640 29364 81682 315509 24366 24367 309684 445442 24511 83727 306628 29302 308995 29583 290905 296456 311061 83502 619374 685269 362800 25118 25353 499431 25246 25406 116479 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamin B6 activation to pyridoxal phosphate 64533 83578 54349 MALATE-ASPARTATE SHUTTLE%REACTOME%R-RNO-9856872.1 Malate-aspartate shuttle 309111 681896 362322 64201 24551 81829 25721 24401 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events 680149 84420 58979 79218 114117 24400 81636 245986 64508 60449 81667 25740 302950 362477 308118 294962 25083 64532 24174 24175 25289 83579 64199 29241 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%10224727 RHO GTPases activate KTN1 361029 64465 117550 171549 314906 316226 363875 171041 117273 308875 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 96%10223841 Zinc efflux and compartmentalization by the SLC30 family 58976 294698 299903 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176409.1 APC C:Cdc20 mediated degradation of mitotic proteins 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 25203 83806 311078 192255 114494 100912032 360643 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 29666 54237 303353 365388 64193 117262 85492 288671 290875 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-RNO-1793185.1 Chondroitin sulfate dermatan sulfate metabolism 50568 25181 300993 404783 84468 367166 29139 24434 363513 25393 294673 114122 500961 291577 291770 297554 500257 304322 302302 314694 316533 25227 316033 81651 300757 286974 301525 361450 365583 297865 DUAL INCISION IN GG-NER%REACTOME%R-RNO-5696400.1 Dual Incision in GG-NER 290027 25591 288651 361580 304719 502227 299112 294693 50522 100362121 291703 192255 288003 361698 171525 304573 25737 302502 100912032 59102 288414 361181 289758 310707 116468 59294 89809 298098 64156 362385 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%10224019 O-linked glycosylation 316583 305571 84430 362275 293667 688673 500152 65196 303692 445442 363040 64442 64445 366061 65044 292406 29758 292325 287899 102550196 313233 83627 313139 308440 25197 690914 102554393 497227 362924 79214 309114 299314 315728 361142 305253 499968 474348 291958 306664 64043 367384 286971 307838 286976 315263 29750 313878 362760 497619 290638 171569 310207 304571 297757 64456 500032 314655 685758 170501 294809 364630 362539 308787 361886 100360475 316091 293004 306549 288611 291212 120100673 310670 100361647 361412 312566 315879 311952 311039 361332 116740 300474 302499 300475 66015 361368 362567 311202 362520 299841 493574 257647 114489 308390 140568 304135 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%10224371 RHO GTPases Activate WASPs and WAVEs 117542 311860 360854 116590 64465 300955 81732 81824 308666 682937 58823 259242 54227 289820 679934 81504 25614 81822 297518 50689 315348 363875 288669 286928 287876 313024 79249 294568 117538 367901 TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions 362279 84006 307237 116479 81918 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 117281 116590 25444 25443 54250 360903 29369 29368 25513 170583 25738 299236 499308 170911 366205 170579 85385 66017 29349 361388 25317 64156 314850 170633 83805 79114 500985 316213 83823 29610 25622 305539 83504 50522 296072 500526 306141 24605 192255 60662 293621 100912032 81504 24525 313845 50689 170700 114486 116499 24673 24672 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223905 Interleukin-7 signaling 680498 25513 25326 25467 29376 25125 24918 688621 60664 25126 310678 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-RNO-174362.1 Transport and metabolism of PAPS 360670 117267 294103 295443 306866 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-RNO-5357786.1 TNFR1-induced proapoptotic signaling 115771 306886 246756 24835 25625 688466 81859 60371 498803 114210 364386 60383 63879 312937 299827 266610 290864 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins 25293 680149 25132 25386 58979 79218 114117 24400 245986 60449 81667 293508 81830 29699 24221 294962 25240 25521 25725 24679 25108 83579 64199 65133 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222217 IRS activation 498416 25467 29376 24506 24505 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-RNO-9818027.1 NFE2L2 regulating anti-oxidant detoxification enzymes 117254 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs 81639 25290 287454 29527 CO-INHIBITION BY BTLA%REACTOME%R-RNO-9927353.1 Co-inhibition by BTLA 116689 407756 25622 81504 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-RNO-2454202.1 Fc epsilon receptor (FCERI) signaling 116667 116590 24244 81511 116554 308267 50658 317546 81736 25493 25513 25738 309361 83477 307366 303024 170911 84477 85243 85385 295378 81745 317676 287772 292766 64156 29669 81515 363875 29668 29425 100360846 29337 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 361831 81827 83806 311078 24605 192255 293621 287280 361765 100912032 100360919 25155 81504 24525 29748 313845 25316 641452 100361818 366962 50689 363577 24674 116725 25047 314322 24675 311245 361400 25441 305311 309295 84492 29431 313121 363855 29432 25272 84351 24516 367901 ABACAVIR ADME%REACTOME%R-RNO-2161522.1 Abacavir ADME 100363253 24904 29503 24172 29504 INTERLEUKIN-37 SIGNALING%REACTOME%R-RNO-9008059.1 Interleukin-37 signaling 25125 299827 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope (NE) Reassembly 246772 679886 117281 498736 114087 362700 117104 64158 24917 25573 301442 316531 296554 365191 54237 29213 287830 291874 113975 292085 295692 116685 117021 362335 366016 362557 297522 500929 25203 81738 683983 25437 682908 307351 282834 291081 364419 500377 307833 363720 361916 246118 84509 500363 313478 679312 287873 300218 24672 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%10222583 Platelet calcium homeostasis 116601 29715 140448 25391 24244 29600 29599 29598 81678 113995 29665 29693 25041 114115 29659 25505 81739 60395 25679 25262 140447 PEXOPHAGY%REACTOME%R-RNO-9664873.1 Pexophagy 312703 113894 64862 303554 192255 64156 304579 50522 100912032 300711 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10224407 Synthesis of 12-eicosatetraenoic acid derivatives 81639 287424 287425 24404 287454 29328 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-RNO-9958825.1 Activation of STAT3 by cadherin engagement 64465 316639 84353 50522 313806 60371 81736 84407 301334 24514 192255 100361294 100912032 81679 50654 25697 311163 25125 83502 304109 64156 363875 83805 24498 63879 361866 305679 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223185 NADE modulates death signalling 25402 29753 24596 117089 310738 64314 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-RNO-9913635.1 Strand-asynchronous mitochondrial DNA replication 85472 303612 309441 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 81751 300802 24918 29192 363014 24890 292788 289231 83805 CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions 24299 29277 171522 25086 24895 54246 308445 24894 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-RNO-174143.1 APC C-mediated degradation of cell cycle proteins 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 24708 287984 65138 94198 294790 25515 29673 295052 29671 29670 29677 29676 29675 50522 310806 305420 361831 366381 292588 81827 293155 292263 25203 83806 311078 192255 114494 287280 361765 100912032 360643 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10223441 HDL assembly 25081 303796 83470 24153 293508 313210 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-RNO-9933939.1 Formation of the polybromo-BAF (pBAF) complex 361925 301020 292404 303518 293514 296732 361825 368001 287876 361374 83833 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-RNO-76009.1 Platelet Aggregation (Plug Formation) 25614 171337 24185 313845 81745 685269 29434 83805 24697 25414 315707 59326 361714 25083 24366 24367 24174 24175 295347 54245 85385 25155 81504 29302 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%10223045 Signaling by FGFR4 117281 116590 25444 54250 25622 29369 50522 29368 500526 306141 170583 25513 170582 25738 24605 192255 293621 170911 100912032 85385 66017 81504 29349 24525 313845 361388 50689 170700 25317 64156 314850 289625 83805 114486 60464 116499 24673 25114 500985 24672 316213 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%10223299 ERKs are inactivated 363193 117281 315648 116663 116590 60587 24673 50689 300980 24672 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism 24244 497197 24655 282636 688862 308451 65038 171088 94267 81677 294292 140693 25738 85238 365382 54259 290651 316376 114633 54260 83523 252899 29337 294429 287830 291874 362281 113975 292085 295692 29688 117021 362335 50557 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 24654 500709 306808 50560 59268 171458 116699 25031 80849 85240 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222905 GABA receptor activation 116649 680149 79211 84420 66013 140675 50599 58979 29713 83633 29712 29718 114117 116560 24400 65187 64508 192258 29695 81667 29694 81664 64199 286924 24611 79218 29709 29708 81636 29707 245986 29705 60449 24947 302950 294962 64532 25686 81657 25289 25643 24922 83579 25743 29241 25451 170847 25450 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 96%10223619 Receptor-type tyrosine-protein phosphatases 300913 308571 140592 312855 302473 309349 306147 25529 310519 306152 360406 25466 29613 290467 293645 317553 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-RNO-68616.1 Assembly of the ORC complex at the origin of replication 680498 303175 365877 64627 301430 313138 306970 295596 690795 310678 302783 24829 24828 313479 291927 117056 306945 362607 24917 685909 680615 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates 64045 290741 294521 313560 298410 102238592 58964 362720 24183 24184 116484 311833 299976 685579 29223 83782 365985 29261 619580 191575 497778 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 96%10223641 Beta-oxidation of pristanoyl-CoA 83842 83522 79244 25541 311849 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222277 SLC-mediated transmembrane transport 140448 64201 83509 50719 24221 58976 25027 503568 58980 24779 691209 29501 54300 308069 83629 171373 170698 246234 140915 58978 84511 140860 259248 432363 114613 360670 117267 306866 29504 25246 50676 117955 114507 114629 64037 170566 314637 360539 361986 296578 63997 295245 25239 311387 294281 84550 498185 29485 29484 192215 363024 65039 291582 362861 362188 85426 252854 140944 170573 294341 29464 311204 309131 85333 366432 84484 64522 192208 501925 25550 25552 310808 362403 289459 295455 29440 117240 363985 294255 314396 114511 84012 65194 289353 266998 296969 311651 170840 171135 85254 680602 85256 498910 56814 252919 155205 295645 246235 287478 24784 246239 24783 246280 117261 297386 24780 24782 116642 24781 65142 83500 365398 305540 24244 266612 291733 295417 317170 303205 315311 29642 304784 304785 315439 171147 60423 25176 54302 24778 54301 85267 29483 116509 287532 170567 65202 266767 29482 24904 305846 113918 314441 664630 29502 25553 29509 29503 311168 24898 29743 116638 301010 79212 89776 171148 25715 83612 300051 353307 298340 79213 94106 309111 297910 282712 64018 117100 81826 83511 29726 681896 310732 171163 306009 84487 29735 25139 25551 311839 363115 170551 25548 84395 316519 80878 50662 363103 116726 294698 313139 299903 307811 65200 29715 170943 84551 50567 140447 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation 29748 100361818 24244 24674 24675 361400 ION HOMEOSTASIS%REACTOME%R-RNO-5578775.1 Ion homeostasis 29132 140448 83535 361618 25560 89821 24244 25650 25262 116601 29715 25391 25390 29600 29599 29598 24598 81678 64672 24211 24212 24213 294141 29693 25400 689560 63847 24245 312981 24246 63848 362013 29248 58950 58971 308405 25679 64190 116831 59299 29639 171140 140447 MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222397 MAPK3 (ERK1) activation 24498 170851 54237 50689 25622 24514 100361294 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 96%10222351 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 24158 171155 29470 170670 140547 113965 MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy 362045 113894 192647 56816 363836 300711 365191 64670 678769 313391 171415 300240 685620 24855 362164 363254 308416 316640 365601 288731 59319 305482 360682 300075 363278 686505 299514 308846 363442 362245 360827 689161 302559 312634 361321 305831 288498 298575 312927 499973 60445 641452 81920 246294 29489 282834 81650 312703 364419 363720 361916 58974 81655 287873 29564 679886 64862 303554 116549 252902 140734 58945 64156 65248 83805 295357 117287 64562 26954 117044 117043 56718 360776 25520 83803 308869 24255 310091 312647 298514 64226 373545 297960 78975 50522 83529 83532 83531 266601 192255 100912032 114558 363131 116725 65052 299827 304017 304579 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 96%10223771 Sodium Proton exchangers 24782 311651 317170 192215 24784 24783 363115 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%R-RNO-1168372.1 Downstream signaling events of B Cell Receptor (BCR) 25023 24244 81736 25493 316241 309361 83477 307366 303024 305584 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 25639 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 29434 81827 83806 311078 24605 192255 293621 287280 361765 100912032 24525 29748 100361818 24674 24675 361400 309295 84351 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions 116561 24392 54241 79128 140694 25751 116563 83800 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%10224317 Trafficking and processing of endosomal TLR 63865 50654 684440 362862 25697 361689 29175 317468 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222067 Proline catabolism FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation 308267 317546 81736 25493 309361 83477 307366 303024 81745 287772 292766 64156 29669 81515 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 361831 81827 83806 311078 192255 287280 361765 100912032 100360919 641452 116725 311245 309295 313121 84351 PHOSPHO-PLA2 PATHWAY%REACTOME%R-RNO-111995.1 phospho-PLA2 pathway 116590 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10224121 Chromatin organization 81736 304809 25573 313539 301442 301128 192246 305479 287768 299620 295270 363064 312974 311607 303511 293184 307362 305501 293038 308738 83726 100359714 50659 300389 81781 360609 291940 64622 113984 406195 361531 303060 103690021 360804 311575 245957 313583 363481 362981 290614 304832 100361269 303607 65027 84486 83724 300837 84353 292019 291295 298144 84401 680891 290284 302553 497941 291794 363026 84578 687711 81785 297893 500569 310678 361402 315606 290925 302783 64646 24829 100362099 83789 24828 444984 303518 502125 89820 296732 100362634 681031 117056 365755 685909 302711 310769 680615 288563 171365 680737 361925 303175 100366024 64627 362831 295384 360531 103689969 60421 303514 299295 306970 289372 304794 360665 312440 498295 317464 83833 689820 306571 363292 317432 684297 84481 102554884 54282 361825 304495 290829 689954 58919 306764 100359816 361688 362825 317425 306945 297867 310352 688634 362093 363630 365155 102550344 315210 303470 680498 682469 291844 301020 298595 83618 365877 679713 689883 296501 29520 308345 309001 689582 310638 290831 690795 293668 314205 29512 29511 266670 364785 297597 299305 94201 83712 100362346 313048 117535 290669 362834 300206 64520 688041 310614 361724 297093 294924 26295 310194 360642 316328 81647 309452 292404 293514 301235 368001 292622 287876 299186 361374 361295 305589 192352 361711 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 310258 361925 301020 303730 116549 50662 361391 315136 307151 83833 681178 81650 303518 296732 361825 313038 309626 297867 288563 501403 EXTENSION OF TELOMERES%REACTOME%R-RNO-180786.1 Extension of Telomeres 290805 308755 364996 84490 295052 171121 287432 297483 170944 499709 288003 114494 367645 691534 361698 25737 362288 301323 287273 59102 288414 289758 116468 306264 59294 89809 85241 301965 309144 290232 297758 500054 307798 307861 303238 294025 RIBAVIRIN ADME%REACTOME%R-RNO-9755088.1 Ribavirin ADME 311422 290029 60423 353307 63997 100363253 140944 83782 24165 191575 25368 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%10222597 Activation of BH3-only proteins 140734 56011 29753 29748 58945 246142 64639 116554 64547 56010 25576 25578 25577 313017 171378 492821 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222043 Amino acid and derivative metabolism 362322 50719 24401 689588 25502 24314 24609 25653 24250 24962 114027 302899 24848 24311 317675 266807 25699 311446 114613 311374 303272 29475 25085 25120 24661 79107 311849 25430 308129 246281 65162 100169747 24792 308652 25611 685325 50690 24264 24265 50676 81660 287772 292766 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 64037 85492 287984 65138 94198 29673 29671 363285 116700 29670 25331 29677 29676 29675 363024 81827 83806 311078 81522 29443 290947 85254 29611 293779 171133 140547 315439 24957 79213 117100 361884 294972 298942 25044 360816 65151 24813 63864 29700 58835 29383 29711 361755 64040 291450 100360621 293871 290484 170907 309150 310152 85309 311358 306574 246307 29221 117024 64192 290551 66029 81640 84596 29592 298607 89833 81670 497840 681319 29215 170898 362428 361215 364064 64313 299201 294421 360975 59085 79251 29301 308800 364975 64564 64203 83784 64206 25134 56823 25721 306586 24513 171151 306840 25618 304429 29416 25612 292710 29531 681913 298934 303306 81508 296925 100365773 81805 288912 361272 312381 25256 298227 63938 81718 311844 691966 300723 79462 289727 367181 116682 83586 301384 24399 170943 25274 24398 50567 192172 29603 365972 81708 309732 685999 305177 25244 300384 25014 59113 192268 114123 246266 300035 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10222827 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 680127 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 TCR SIGNALING%REACTOME%R-RNO-202403.1 TCR signaling 81511 308267 315707 81736 25493 25513 25738 309361 83477 307366 303024 54259 170911 85243 81745 287772 292766 29433 64156 29669 29668 29425 100360846 29337 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 300955 29677 50557 29676 29675 295338 294269 50522 300678 313050 24981 361831 25300 25710 24986 81827 24932 83806 311078 192255 287280 361765 100912032 641452 366962 363577 116725 311245 309295 24699 310727 64019 499537 29431 313121 362491 29432 84351 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 96%10225099 RUNX1 regulates transcription of genes involved in BCR signaling 500453 361944 50662 361391 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223469 ABC-family protein mediated transport 300664 362302 301482 155192 25081 140669 83519 363516 170924 299027 54318 296302 287772 292766 289874 64156 302973 29669 29668 29425 100360846 290823 117263 25581 407784 29666 303353 116643 365388 117262 85492 24255 287984 65138 83535 362891 94198 25560 29673 29671 140668 29670 29677 690315 29676 29675 360967 50522 81827 83806 311078 192255 100912032 25270 84356 114628 116721 24891 85493 286970 303639 287788 79248 81642 25303 302395 299609 24565 63886 314537 NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 96%10223189 NFG and proNGF binds to p75NTR 24596 310738 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) 58960 315994 117281 116590 314910 315305 114090 501560 300078 501099 314612 300980 25513 59109 116663 310738 60587 170911 85243 116478 54245 85385 29376 65046 314850 116743 140670 117273 83800 54241 116563 117535 295347 56011 170851 24605 287942 293621 29622 81504 24525 315648 81646 313845 50689 81771 114486 117269 363193 25467 24673 289014 24672 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism 313574 116593 315219 81656 289801 287368 65135 295620 312373 METAL ION SLC TRANSPORTERS%REACTOME%R-RNO-425410.1 Metal ion SLC transporters 361986 24782 140448 311387 24244 294281 291733 84550 498185 317170 192215 362861 58976 85267 305846 25715 29715 300051 294698 295455 299903 117240 363985 306009 314396 289353 363115 311651 170840 171135 56814 316519 24784 24783 314637 140447 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse 306790 316009 25537 362993 64373 117273 78966 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 29666 54237 303353 365388 117262 85492 288671 290875 287984 65138 94198 25515 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 292263 25203 83806 311078 192255 114494 287280 361765 100912032 360643 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability 81679 24185 64226 25233 311163 24244 24600 81745 29414 315189 29433 84353 363875 296648 310131 29431 246273 299331 361992 29432 56718 295378 DRUG ADME%REACTOME%R-RNO-9748784.1 Drug ADME 83783 60423 301005 63867 295088 498940 362329 290681 24904 312086 116632 116631 170924 84024 29503 25027 300981 113992 295378 89776 290029 353307 24165 24465 25368 363875 29277 171522 25086 83782 266682 252931 191575 63997 170698 140668 58978 140860 408206 116568 291394 24172 25260 494499 140944 29566 156275 497811 24421 24422 24426 498790 494500 113902 266685 501907 286954 501110 299270 286989 307092 25116 25117 291283 361266 65194 690050 171516 24186 29504 307096 364773 311422 498789 191574 100363253 116721 24902 293779 24912 353317 246263 688536 361637 25246 24861 312382 360268 25303 361510 24565 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME DATABASE ID RELEASE 96%10225197 Biosynthesis of E-series 18(S)-resolvins 81639 299732 25290 29328 79242 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%10225531 CHD3, CHD4, CHD5 subfamily 680498 365877 310614 361724 297093 297893 690795 310678 302783 24829 24828 117056 685909 680615 303511 303175 307362 305501 293038 64627 25573 100359714 50659 300389 306970 360609 301442 291940 64622 113984 406195 83712 303060 360804 100362346 313048 117535 306945 290669 362834 64520 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-RNO-1852241.1 Organelle biogenesis and maintenance 117281 363272 171044 64158 311573 311802 311529 290626 365153 300963 362553 315423 296618 170714 24787 683722 314523 29479 500086 363055 361596 299209 100910342 305467 24818 366403 685284 298767 64632 367153 288305 360672 300062 308064 363544 294864 373066 365770 252921 311123 316102 499814 314961 304007 293844 60627 100362495 25309 295230 316531 288585 300675 171455 296554 85258 500571 24650 363286 310344 116654 287541 313365 252881 314787 363760 498095 60347 50556 246150 295106 29214 363126 299331 500069 690675 361789 113948 29213 245709 81740 192228 64664 25411 307347 305882 500832 315484 311456 29374 299246 114089 362142 293615 679894 305287 367714 299809 287612 361930 65209 117103 307724 100362124 305349 303968 295654 116475 289168 689779 312651 366872 503018 308923 362265 680407 287383 300880 85248 303915 293148 296136 313170 287836 117515 361727 266809 29753 309486 81830 29489 29885 245958 140608 300677 171082 309451 94271 245965 26197 26196 114764 171069 29754 362749 79120 641434 690441 83836 192241 171375 171374 65262 299850 64462 311191 308443 83572 140734 58822 58945 24717 56010 54237 29167 294010 83567 25515 306840 25273 24399 24679 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars 310808 313139 311204 306866 296969 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-RNO-9970672.1 FXIIa activates plasma kallikrein-kinin system 680498 681544 303175 365877 64627 25087 306970 50692 310678 306761 302783 24829 24828 295703 293118 117056 58940 306945 300250 680615 24153 29681 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-RNO-205043.1 NRIF signals cell death from the nucleus 113894 81751 362548 64156 311245 50522 289231 24596 310738 300802 192255 29192 100912032 292788 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-RNO-69560.1 Transcriptional activation of p53 responsive genes 685474 24842 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-RNO-3214841.1 PKMTs methylate histone lysines 680498 291844 688041 689883 294924 308345 309001 310638 290831 310678 315606 81736 364785 100362634 302553 100366024 64627 362831 299295 289372 304794 309452 498295 689820 83712 290829 313048 689954 306764 100359816 361688 362093 365155 102550344 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation 81736 25493 54226 309361 25742 287707 84351 309452 309295 GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly 497913 29584 50563 84403 29586 79217 50564 363677 24392 394266 266707 25655 266706 29585 TRANSLATION%REACTOME%R-RNO-72766.1 Translation 303746 295238 293054 309176 298517 291685 26203 26202 26201 26200 293754 297799 361883 690345 363023 311903 301552 299628 497876 686234 26195 26194 26199 26198 26193 683519 26192 315141 288916 294230 641452 309140 100363539 360594 500199 299938 292758 287962 295224 81920 296551 171061 94266 292244 363646 116650 689432 312199 361473 108348073 287119 361005 310653 362216 297601 56281 309440 287656 297459 315769 301250 301371 364656 287302 293666 294754 114017 296134 64360 303685 113958 294767 293725 684304 308306 363241 171361 680747 301352 300033 290850 292762 297372 682390 301240 298700 498402 25348 498406 691947 362952 81775 81776 299872 81773 81774 293427 288599 303831 65136 691531 27139 288516 294282 122799 29236 681429 117053 287772 292766 64525 100362640 64156 161477 292148 29669 100361756 29668 29288 29287 29425 29286 100360846 29285 299899 124323 117263 140654 25581 171350 140655 293408 29666 29284 300069 303353 293484 103689992 365388 122772 29258 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 361831 81827 83806 311078 192255 100912032 81807 293453 289508 192234 299027 54318 117019 296302 64514 171145 310856 29565 83789 291434 81729 25347 28298 64205 26962 100910714 64298 290641 26197 26196 361923 134480579 117042 287122 499782 140661 140662 29257 300079 292964 293418 81768 100361974 362631 360572 245981 497860 81770 64640 81764 81765 81766 81767 81763 29304 100361060 58927 117045 689284 116636 29283 29282 296709 64302 64306 100360439 64307 134486107 24206 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 96%10224139 Endosomal Vacuolar pathway 365527 414786 24988 24223 24750 24974 680842 171105 499400 PTK6 DOWN-REGULATION%REACTOME%R-RNO-8849472.1 PTK6 Down-Regulation 296472 366275 24697 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling 25125 85491 29144 680609 290655 24514 100361294 84405 171334 171333 689932 365368 25506 155140 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-RNO-159854.1 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 81716 306608 29243 24946 25268 54281 260320 25295 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-RNO-1855204.1 Synthesis of IP3 and IP4 in the cytosol 500709 24244 50557 497197 24655 25031 65038 308451 29337 85240 171088 81677 25738 140693 85238 54259 114633 54260 24654 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222941 Classical antibody-mediated complement activation 29687 362634 25419 312705 100360919 298566 192262 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-RNO-9623433.1 LXRs regulate gene expression to control bile acid homeostasis 58851 METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals 689415 117038 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 96%10223481 Platelet degranulation 24617 24795 24791 24244 311795 25651 84491 83785 307396 114111 89811 360457 246328 24366 54226 299909 24367 360918 81809 170924 59086 29302 63836 25524 60327 25717 25313 293676 294643 25087 24189 363104 113947 24825 685269 25373 364206 316531 305679 24446 246358 25266 24628 84590 85253 24186 24936 293860 309609 24153 360942 116510 24944 25081 305021 56782 81634 361196 54249 363015 24648 500152 100359512 498299 445442 686539 29583 363195 302470 307986 24786 116635 54404 312159 360950 140656 296488 24614 81804 29186 24854 245955 315989 304983 295703 81814 116662 140594 309186 681544 293628 50693 682967 293886 24483 24482 94168 289316 287876 304805 308291 25673 ICOS CO-STIMULATION%REACTOME%R-RNO-9927354.1 ICOS co-stimulation 25513 497932 499415 366508 64545 298947 170911 60664 497931 85243 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%10224247 Acyl chain remodeling of CL 171155 170670 363521 362702 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-RNO-74160.1 Gene expression (Transcription) 290805 308755 497672 114495 64557 24484 308986 363924 303194 315969 25242 64046 25243 85482 304809 59086 192218 114212 685055 310034 25573 306734 54281 301442 305000 300711 297627 360588 497856 64012 294800 368002 498411 291787 24855 100361529 140583 363064 24942 24185 60445 29753 25233 685474 25576 25578 25577 84509 313131 307511 311575 29414 313017 304798 686980 58936 81745 304832 161452 83805 302415 29417 312451 84486 300837 116700 50554 291534 25329 314993 25631 84353 288003 25737 288414 116468 292064 115771 681062 24577 81516 116484 29357 360471 60331 24208 308911 302553 497941 24705 685072 25682 58851 64466 304758 362479 192350 84578 500715 687711 683469 81785 306998 25149 100362099 362110 294515 681031 25154 365755 302711 171365 680737 83574 60349 289372 171068 300266 406162 306571 363292 365155 315210 292778 679713 288651 689883 288588 361580 316123 689116 502227 294693 83503 311796 298075 361365 690966 117017 305455 679203 291703 363633 498109 289561 317399 301246 294687 362095 114205 316810 311487 310685 361102 685465 313914 246299 690254 685539 24398 306012 304204 362537 306542 192268 287876 361374 64314 25309 170824 690675 84482 26195 26198 363445 293184 50659 81920 361531 363481 303539 687001 297453 362981 689844 56761 310405 363287 113898 679028 252860 84580 102556092 303101 287772 58839 292766 64525 64156 316034 140923 305025 29669 102553962 29668 296102 259241 29425 100360846 58850 58853 102547287 65261 117263 65035 25581 686781 114592 305120 29666 54237 686774 58983 303353 140942 365388 108348224 498160 117262 690728 85492 102555083 303393 60351 24708 54278 282845 287984 365224 65138 295448 286979 94198 296653 83724 100912096 303281 29673 308971 295052 299810 29671 29445 29670 303132 29677 102548695 29676 286996 117254 29675 114510 291773 50522 293044 317256 83828 29338 83722 361831 170844 81673 102549410 83830 303226 306977 171152 81827 102555289 309638 100158223 288533 685619 25203 373541 83806 364298 293345 294018 102546572 311078 307839 192255 303918 102547413 117526 114494 291841 287571 100909569 94194 100912032 299694 299210 681024 84396 266734 102550851 114208 315648 314586 192178 315427 287361 691153 306966 81807 287249 24522 25735 78972 680155 102555170 85261 300197 306816 365192 306817 304514 81808 313596 24673 502988 171335 311130 298533 245980 266787 299284 300813 363006 102546648 288514 298558 298681 24672 100188937 362045 54322 499874 117281 499994 367034 116590 140908 266774 298688 500108 502894 114491 171355 116671 362813 303774 114490 305837 301119 64028 683593 313219 291705 360764 100360287 24377 24370 680200 84683 361988 360896 293625 312227 102555672 287076 156726 311591 314862 84469 292804 120095871 289382 313777 287094 295707 134478826 310233 297065 363603 499929 691379 498952 293701 102556967 100362678 297066 312303 313757 360229 498945 360589 291772 102553002 25405 311546 314818 24842 300782 494339 499900 301513 25591 500855 56011 293615 25533 309002 282844 64033 313978 25622 685925 293849 691504 297893 308362 362675 654441 24890 688328 310678 309457 307151 252917 315606 100364132 302783 691610 24829 291164 24828 444984 311414 303518 170955 296732 690895 100362634 25282 25193 308582 313038 497923 304690 361487 117056 100362083 309626 246334 363014 291877 29657 685909 311670 117274 501688 680615 60661 288563 311166 680717 25720 299256 100364568 310258 102553866 365407 361925 314417 100365779 303175 299811 306261 116697 303730 362358 304277 25697 308561 366468 64627 308320 295384 289582 308326 25172 365744 683927 60421 308322 301164 246279 306970 688386 304794 311613 266713 681740 361391 691422 315136 252924 83833 363221 689820 681178 60571 311567 120093538 81650 366975 313507 363227 500453 100365683 361825 499068 290829 362272 58919 29619 361944 286917 100359816 306492 306945 361057 297867 690559 25159 246264 362093 100362170 102550344 252934 501403 311860 680498 301020 171046 365877 116549 84389 85471 114483 29175 309001 50662 690795 362485 59102 290270 100360427 24790 83571 290744 309757 24413 25747 680111 65248 361178 56010 83712 24873 497991 25664 295357 619436 64562 100362346 83516 310958 313048 304714 314621 26954 289881 117535 291567 361784 117044 360893 300367 293500 361420 117043 83826 498112 290669 56718 362834 300206 116698 360776 291440 64520 25520 83803 313245 313323 300320 308869 207118 680493 84027 287662 310091 306030 306274 298514 362728 314964 299569 64226 83582 373545 688041 25672 360581 690450 299607 83581 287475 297960 310614 303403 361724 84385 299180 297093 24666 81812 311468 25574 26295 78975 362414 293488 317343 310194 316209 360642 362224 316328 314704 85265 290939 289307 299905 83474 679693 25498 50689 315189 313558 690516 296648 116723 89812 310131 79240 140607 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines 299827 498840 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport 59108 170520 85382 SERINE METABOLISM%REACTOME%R-RNO-977347.1 Serine metabolism 58835 304429 25044 294421 360816 303306 170907 311358 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223703 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 266607 85240 81662 81666 24654 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-RNO-446353.1 Cell-extracellular matrix interactions 57341 362650 363509 170922 362973 81634 29460 362332 24511 360820 293860 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-RNO-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 64314 114495 301512 308267 60371 317546 24888 116725 300732 117514 311245 282817 315435 309295 58923 116484 311567 29665 500133 301252 360557 290408 304987 287362 64044 312937 313121 60352 362491 58918 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%10223285 TNFR2 non-canonical NF-kB pathway 25069 683163 25341 89814 353218 302424 500910 171369 361795 24835 25625 498666 360548 252878 60371 156767 117516 117553 25008 84349 500592 500590 365581 309361 296872 360640 303024 25572 498769 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 287280 361765 100912032 309452 362788 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223463 Intestinal lipid absorption 432367 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism 289950 298942 50522 81654 288731 81530 89813 83529 681913 192255 117098 24439 294320 100912032 24533 24534 24651 298982 83536 307270 25104 315949 361602 497900 302980 290705 369018 64156 296849 311254 364686 246311 54705 81670 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%10222929 Signalling to RAS 24525 315994 313845 24605 293621 314612 29622 85385 289014 81504 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-RNO-202131.1 Metabolism of nitric oxide: NOS3 activation and regulation 170520 24185 292894 25751 24244 24600 64157 311111 298184 25514 80773 299331 29270 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%10222193 Caspase activation via extrinsic apoptotic signalling pathway 25402 306886 246756 117279 25311 448830 364867 363328 64044 60350 29260 266610 246097 25385 58918 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10225481 Complex IV assembly 289522 304735 26198 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%10223423 Apoptosis induced DNA fragmentation 680522 25402 201097 84359 684828 24437 24917 498072 291145 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 96%10222555 G alpha (12 13) signalling events 306618 66013 500608 29413 287537 29412 287418 84009 120099896 310635 311647 64373 310999 78966 307398 117020 316009 309653 303634 301334 295449 363460 293024 24816 100362710 362648 295378 298404 310460 307098 246174 313845 363509 114559 140898 361921 25537 304109 310192 687105 29491 117273 317598 81663 114513 367901 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224473 Syndecan interactions 24680 116673 24771 296456 25724 54250 170921 24511 25216 59086 25615 29302 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates 498265 290805 308755 497672 293452 64557 291787 689055 102551085 303194 498119 499966 64046 85482 289777 287634 192218 293489 306734 305000 300711 302982 360588 497856 302953 64012 499870 293678 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins 113975 287662 83422 292085 688041 316164 295692 117021 362335 297893 366016 58958 307151 362557 65274 113929 297522 245922 81738 313038 683983 53372 309626 25497 499974 310258 303730 363287 64627 690244 25573 301442 499417 300772 294429 501145 287830 291874 300320 362281 501403 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins 306608 29243 24946 25268 54281 260320 25295 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222897 G2 M DNA replication checkpoint 25203 295052 54237 114494 308937 287101 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-RNO-9909505.1 Modulation of host responses by IFN-stimulated genes 309361 310968 298693 361810 295704 84351 309295 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223787 Inorganic anion exchange by SLC26 transporters 297910 29440 360670 114629 117267 304784 301010 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 96%10225063 CREB3 factors activate genes 314638 303016 89842 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-RNO-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins 680498 365877 689883 690795 310678 302783 24829 24828 102546572 361487 117056 100909569 685909 680615 303175 120095871 64627 306970 24522 300266 102556967 365192 306945 108348224 690559 246264 116698 100362170 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 96%10224713 Intraflagellar transport 65209 100362124 305349 303968 295654 116475 289168 312651 503018 362265 85248 365153 362553 140734 296618 170714 314523 58945 500086 299209 685284 298767 300062 363544 373066 311123 499814 288585 300675 500571 363286 287541 313365 498095 295106 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-RNO-173599.1 Formation of the active cofactor, UDP-glucuronate 246232 83472 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224093 G protein gated Potassium channels 116649 680149 50599 58979 29713 79218 29712 83633 29718 114117 116560 24400 245986 60449 81667 294962 81657 83579 64199 25743 170847 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-5651801.1 PCNA-Dependent Long Patch Base Excision Repair 59294 89809 84490 298098 79116 29240 299112 362385 288003 361698 304573 25737 288414 59102 289758 116468 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%10225477 PDH complex synthesizes acetyl-CoA from PYR 117098 289950 298942 81654 311254 G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events 84420 116590 24244 170538 64508 81742 25050 81666 24681 29699 24680 81662 81664 60341 29691 24654 286924 83506 24611 81636 25238 25031 293508 302950 85240 64532 25521 25686 25289 25643 25725 24679 29241 DIGESTION%REACTOME DATABASE ID RELEASE 96%10223083 Digestion 25680 497039 25711 25656 289032 113901 64055 117554 50682 84028 363465 25702 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 96%10225499 Regulation of PD-L1(CD274) Post-translational modification 116549 287772 292766 289874 64156 94201 290783 29669 65248 29668 362040 56010 29425 116967 100360846 290823 117263 192275 25581 407784 64562 29666 100188932 303353 116643 365388 309304 290638 117262 686092 85492 301626 25520 83803 84027 287984 313648 65138 362891 94198 373545 363160 29673 301555 499342 29671 287643 29670 64701 29677 690315 29676 78975 29675 360967 50522 81827 83806 311078 192255 287280 361765 100912032 81650 58919 ATORVASTATIN ADME%REACTOME%R-RNO-9754706.1 Atorvastatin ADME 266682 312086 252931 58978 140860 84024 25303 ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins 498659 24691 498658 286995 613220 362347 613223 613224 286958 25052 613225 24932 308873 290856 683849 103690254 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223393 Catecholamine biosynthesis 24311 25699 25085 24661 VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223127 Vesicle-mediated transport 117106 84018 108348178 294324 361244 361120 296750 60668 117277 60422 317396 362118 60568 311854 60566 312701 60564 500906 83576 363466 54226 25377 25372 363476 79214 299858 24440 360504 29216 64670 288700 307868 365793 292886 689102 64633 292760 311494 501854 315059 313234 24855 25183 29662 312257 362599 117103 299799 307039 363123 290746 499768 361987 294709 171452 361227 363326 306229 360827 287427 94193 24942 287709 79121 94197 361555 24185 60445 29753 25233 252916 84590 50645 287110 287624 367073 365372 313493 246324 29448 295333 207119 81830 246294 29489 81754 282834 79434 315668 364419 81756 680465 363720 29885 58974 361916 84589 308942 366896 81655 360956 309678 287873 360797 363059 266688 303734 246772 29564 300147 679886 288779 317580 64862 25532 25531 313340 29414 299075 316017 252902 311880 292074 114638 367915 315999 361697 362983 315756 84379 311911 25530 501550 85238 289350 360768 363235 691042 83572 140734 58945 64558 83805 50592 24255 25387 25388 300678 25710 24932 303251 313474 25751 252929 498798 85256 311030 292994 56084 25490 299825 25716 300158 316226 64516 361308 363288 297522 289168 171291 113886 293502 315740 85248 171041 313254 353302 294286 246209 303575 24186 303659 314473 289309 117548 64154 117550 171549 289994 293456 64310 362162 314906 361073 309523 54350 289397 287276 309451 60355 65134 25728 297428 290994 54225 300888 246117 25081 79120 304290 54400 58842 363136 690252 171121 192243 299850 310411 24648 300743 64462 100912115 56042 252853 89868 140940 60384 290659 64351 65165 300674 291990 25423 685144 25108 299121 362237 306264 309010 140673 503165 246310 690961 361705 301012 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 304978 360922 116666 117513 100360302 94189 29167 84428 79117 361207 252889 58817 93646 314030 295461 294010 361577 81803 25073 94195 24807 362862 24791 81645 24221 24825 29491 64678 83800 116561 85491 24392 54241 288785 100362805 79128 365191 140694 116563 366618 171575 315840 83730 366311 313409 304344 24468 394266 266707 310746 25655 361459 306332 266706 29585 500985 497913 29584 50563 84403 29586 79217 50564 363677 503164 315111 24803 81732 64630 289820 192348 116717 297518 360915 65046 64156 116743 24180 140670 288669 171574 84393 360854 81824 117254 50522 192255 100912032 100360919 361632 25306 89816 25238 261736 24827 313934 117039 296649 500249 362283 100361513 29528 192152 25433 309798 65277 25313 64187 286932 293344 685079 25218 120097389 312689 25151 60562 364981 309922 117051 311919 24329 64202 59325 29183 64022 314641 310839 641528 363273 363266 140932 24805 64189 363283 287645 65178 124461 687208 295217 297995 367308 81659 364183 317630 114590 114113 289257 292925 290635 305614 64159 298598 683687 290639 314251 292944 81504 360953 290775 287367 296199 266606 314349 81922 116692 308458 116691 681059 58917 192154 310097 295171 81921 100359675 306809 29292 29704 362609 360426 64621 689256 312694 360202 362502 294900 289312 300438 117028 25319 24464 84357 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 96%10222285 Carnitine shuttle 373545 64562 404280 29726 25413 25756 78975 25757 25682 FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization 292767 366174 680264 689349 100910102 680912 500052 290989 362623 499152 100362588 24936 24163 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%10224617 WNT5A-dependent internalization of FZD4 116561 24680 54241 25023 116563 303251 25388 65046 140670 64558 83800 24681 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 83588 680149 307234 25051 58979 79218 114117 24400 245986 60449 81678 81667 293508 59326 294962 295347 25679 83579 25262 64199 25736 246153 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-6807062.1 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 309262 293688 78968 300095 298298 29540 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-RNO-73943.1 Reversal of alkylation damage by DNA dioxygenases 303193 291905 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 64026 100360940 63879 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190374.1 FGFR1c and Klotho ligand binding and activation 170583 79114 83504 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%10224579 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 116685 302935 304569 94165 363849 84017 117062 291145 680522 201097 684828 24437 24708 24842 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%10225361 Sensory perception of sweet, bitter, and umami (glutamate) taste 286924 500101 500089 100310876 500091 554302 24400 689869 78979 29407 60449 78981 78980 170634 78983 78985 680188 690448 25679 246219 100270683 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-RNO-212436.1 Generic Transcription Pathway 290805 308755 497672 114495 64557 24484 308986 363924 303194 315969 25242 64046 25243 85482 304809 59086 192218 114212 685055 310034 25573 306734 54281 301442 305000 300711 297627 360588 497856 64012 294800 498411 291787 24855 100361529 140583 24942 24185 60445 29753 25233 685474 25576 25578 25577 307511 311575 29414 313017 304798 58936 81745 161452 83805 302415 29417 312451 116700 50554 25329 314993 25631 84353 288003 25737 288414 116468 292064 115771 24577 81516 116484 29357 360471 60331 24208 24705 685072 25682 58851 64466 304758 362479 192350 84578 500715 683469 81785 306998 25149 362110 294515 25154 365755 302711 83574 60349 289372 406162 306571 363292 365155 315210 292778 679713 288651 288588 361580 316123 502227 294693 83503 311796 361365 690966 117017 305455 679203 291703 363633 498109 289561 24398 192268 361374 64314 25309 170824 690675 84482 26195 26198 363445 50659 81920 363481 303539 687001 297453 362981 689844 56761 310405 363287 113898 679028 252860 84580 102556092 303101 287772 58839 292766 64525 64156 316034 140923 305025 29669 102553962 29668 259241 29425 100360846 58850 58853 102547287 117263 65035 25581 686781 114592 29666 54237 58983 303353 140942 365388 108348224 498160 117262 85492 102555083 303393 60351 54278 282845 287984 365224 65138 286979 94198 100912096 29673 295052 299810 29671 29445 29670 29677 102548695 29676 286996 117254 29675 291773 50522 293044 317256 29338 83722 361831 170844 102549410 303226 306977 171152 81827 102555289 309638 100158223 288533 685619 25203 373541 83806 364298 293345 294018 102546572 311078 307839 192255 102547413 117526 114494 291841 287571 100909569 94194 100912032 299694 299210 681024 84396 266734 102550851 114208 315648 314586 315427 287361 306966 81807 287249 24522 25735 78972 102555170 300197 306816 365192 306817 304514 81808 313596 24673 502988 171335 245980 300813 102546648 298558 24672 100188937 362045 54322 499874 117281 499994 367034 116590 140908 266774 500108 502894 114491 171355 116671 114490 305837 683593 313219 360764 100360287 24377 24370 680200 84683 360896 293625 312227 102555672 287076 156726 314862 84469 292804 120095871 313777 287094 295707 134478826 310233 297065 363603 499929 498952 293701 102556967 100362678 297066 312303 313757 360229 498945 291772 102553002 25405 311546 314818 24842 494339 499900 301513 25591 500855 56011 293615 25533 309002 282844 64033 313978 25622 685925 293849 691504 297893 308362 362675 654441 24890 688328 310678 309457 307151 252917 315606 100364132 302783 691610 24829 291164 24828 303518 170955 296732 690895 100362634 25282 25193 308582 313038 497923 304690 361487 117056 100362083 309626 246334 363014 29657 685909 117274 680615 60661 288563 680717 25720 310258 102553866 361925 100365779 303175 303730 362358 25697 308561 64627 308320 295384 308326 25172 365744 60421 308322 301164 246279 306970 688386 304794 311613 266713 361391 691422 315136 252924 83833 363221 689820 681178 311567 120093538 81650 313507 500453 100365683 361825 499068 290829 362272 58919 29619 361944 100359816 306492 306945 297867 690559 25159 246264 362093 100362170 102550344 252934 501403 311860 680498 301020 171046 365877 116549 84389 85471 114483 29175 309001 50662 690795 362485 59102 100360427 24790 83571 290744 309757 24413 25747 680111 65248 361178 56010 83712 24873 497991 25664 295357 64562 313048 314621 26954 117535 117044 117043 83826 290669 56718 362834 116698 360776 25520 83803 300320 308869 287662 310091 298514 64226 373545 688041 25672 297960 310614 361724 84385 297093 24666 81812 78975 25498 50689 315189 313558 690516 296648 116723 89812 310131 79240 140607 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%10225245 Activated NTRK2 signals through FRS2 and FRS3 24225 313845 314850 25730 25054 81504 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222545 Release of apoptotic factors from the mitochondria 100360940 690675 353316 116502 287606 25309 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-RNO-3134975.1 Regulation of innate immune responses to cytosolic DNA 313264 192255 299827 292892 64156 50522 100912032 314336 499069 308901 498840 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE 292778 288651 84389 288588 291534 361580 316123 502227 266713 294693 83503 361365 690966 117017 291703 363633 498109 289561 313131 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10221973 p53-Dependent G1 S DNA damage checkpoint 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 81827 83806 362485 311078 304798 192255 114494 100912032 360860 114212 83571 287772 292766 64156 685474 29669 29668 300711 29425 100360846 117263 25581 29666 303353 365388 117262 85492 311575 24842 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224311 Synthesis of PIPs at the ER membrane 300147 305419 116482 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224945 Synthesis of PIPs in the nucleus 89812 364298 116723 140607 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane 305540 29485 29484 29642 83509 50719 315439 170573 287532 29464 170567 113918 314441 664630 311168 192208 50676 116726 298340 84551 50567 282712 252919 155205 246235 170566 307811 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%10222893 Signalling to ERKs 24525 315994 58960 56011 313845 116590 50689 314850 314612 114486 59109 310738 170851 24605 287942 293621 295347 116478 29622 54245 85385 289014 81504 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10221939 Lagging Strand Synthesis 59294 89809 84490 85241 288003 361698 25737 301323 288414 59102 289758 116468 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222593 Activation of BID and translocation to mitochondria 64625 171528 259274 64044 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%10223317 Caspase-mediated cleavage of cytoskeletal proteins 25402 24170 64026 296654 64044 64159 81818 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223271 Extra-nuclear estrogen signaling 363425 116590 24244 25335 29414 24890 85252 25149 306792 25513 81664 294515 25718 24605 293621 170911 60664 85385 25522 59325 286924 25614 29183 24525 24185 81646 25233 83571 25433 25313 24600 81745 60421 298184 64022 170897 83805 29149 25686 24329 299331 81687 25643 24827 81686 170906 246332 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription 156726 50554 25631 59086 24842 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222601 Activation of BIM and translocation to mitochondria 58945 116554 64547 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-RNO-2029485.1 Role of phospholipids in phagocytosis 289211 29340 170538 25096 300678 25097 29337 25513 360426 25738 309014 361527 170911 85243 100360919 25155 295279 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10223077 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 362485 24708 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins 113975 83422 292085 295692 117021 362335 366016 58958 362557 65274 362827 113929 297522 245922 81738 683983 53372 24874 25497 499974 25573 301442 300772 291171 294429 287830 291874 362281 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 96%10223019 Conjugation of phenylacetate with glutamine 246263 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 96%10222791 MyD88-independent TLR4 cascade 315599 315994 117281 500900 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 60371 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 266610 306886 246240 64156 25622 50522 361831 192255 287280 361765 100912032 315648 81646 641452 50689 25742 81647 116725 314322 311245 309452 81920 309295 81771 293624 310877 287545 117269 246294 448830 500133 364867 363193 363520 252961 363328 291921 60350 64044 29260 313121 24673 362788 362491 299827 292892 287707 363855 25272 84351 24516 289014 24672 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma 25081 58917 503164 24186 312701 315111 25377 299858 360922 24440 360504 100360919 24464 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10222169 RNA Polymerase I Transcription 680498 365877 84389 288651 361580 502227 294693 690795 83503 690966 291703 498109 83712 100362346 304714 313048 117535 361784 360893 361420 290669 362834 64520 313245 680493 306274 362728 83582 690450 83581 310614 361724 297093 25574 297893 310678 302783 24829 24828 301246 117526 117056 685909 680615 303175 64627 50689 306970 266713 306945 ACTIVATION OF SMO%REACTOME%R-RNO-5635838.1 Activation of SMO 25273 25238 113927 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%10225215 LXR-mediated signaling 497941 84578 365755 302711 58851 313210 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%10222861 Oxidative Stress Induced Senescence 680498 315994 365877 116590 114495 114483 116554 690795 50658 304798 25164 64156 494444 94201 83712 313048 294917 365057 24842 688041 50522 310678 307151 302783 24829 24828 313038 192255 117056 309626 685909 100912032 680615 310258 303175 303730 64627 50689 306970 314322 315136 116484 306945 363855 25272 24516 363630 289014 501403 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%10225493 Formation of the dystrophin-glycoprotein complex (DGC) 299940 500364 432360 305941 307548 362715 25592 691517 114489 303468 298936 497892 24907 66027 309816 25600 MITOTIC PROMETAPHASE%REACTOME%R-RNO-68877.1 Mitotic Prometaphase 117281 692032 64158 311573 309098 311802 311529 290626 305392 680089 300963 362519 315423 362438 171566 362203 683722 29479 363055 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 316531 296554 287929 310344 680991 312754 314787 60347 246150 29214 299331 500069 362980 29213 81740 294429 192228 307347 305882 287830 498265 299147 292085 684771 308870 305343 304218 290577 24669 313861 297522 81738 683983 29753 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363028 81650 315164 304951 289150 361416 363174 81655 303037 363059 114764 29564 286993 114514 298850 116549 83836 363198 362548 304477 298594 170845 252902 85252 299850 287598 307805 64462 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 363481 305270 83572 140734 681050 58822 58945 684439 313304 63996 64515 56010 297176 114592 54237 29167 294010 25515 25203 315648 363193 309179 24673 24679 24672 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 117278 64191 298298 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks 64046 85482 64012 192218 300711 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-RNO-1237044.1 Erythrocytes take up carbon dioxide and release oxygen 25240 54231 29242 310218 24440 304805 360504 65207 24779 171015 365345 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME DATABASE ID RELEASE 96%10223187 Cell death signalling via NRAGE, NRIF and NADE 306618 66013 500608 113894 287537 64314 287418 362548 64639 84009 116554 120099896 310635 311647 310999 78966 307398 117020 309653 303634 310738 301334 295449 300802 363460 293024 100362710 29192 362648 292788 295378 298404 25402 310460 307098 246174 117089 363509 81751 114559 140898 361921 304109 64156 310192 64547 687105 363875 29491 289231 114513 50522 192255 100912032 29753 313845 311245 317598 24596 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-RNO-8964539.1 Glutamate and glutamine metabolism 362428 24399 364064 24398 64313 24957 361755 192268 311844 25721 300035 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%10224655 Release of Hh-Np from the secreting cell 84399 84380 303743 311324 499241 29499 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-RNO-5419276.1 Mitochondrial translation termination 26196 301250 301371 364656 287302 293666 296134 64360 303685 113958 294767 684304 680747 301352 290850 297372 301240 498406 303746 295238 293054 309176 298517 26203 26202 26201 26200 293754 297799 361883 363023 311903 301552 299628 497876 686234 26195 26194 26199 26198 26193 683519 26192 288916 294230 309140 100363539 360594 500199 299938 292758 287962 295224 296551 171061 292244 363646 689432 361473 361005 310653 362216 297601 56281 309440 287656 297459 26197 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223891 Other interleukin signaling 25402 25613 81802 24932 25012 116470 81803 24803 81804 25216 682457 498951 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-RNO-1222556.1 ROS and RNS production in phagocytes 170667 436582 297566 312488 24600 117596 94170 116664 366545 24598 66021 287610 297932 79129 298103 29757 289407 24599 316519 362802 368044 296981 298451 299971 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-RNO-9909649.1 Regulation of PD-L1(CD274) transcription 680498 303175 688041 365877 64627 306970 304794 690795 310678 315606 302783 24829 83712 24828 313048 290829 117056 306945 685909 362093 680615 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-RNO-9674555.1 Signaling by CSF3 (G-CSF) 25734 24525 641452 25622 81807 64525 64156 64624 81515 50522 81920 361831 24514 192255 100361294 84477 100912032 85385 89829 25155 81504 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 96%10224405 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 29277 502969 25426 313375 24296 24297 65030 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%10222549 SMAC, XIAP-regulated apoptotic response 25402 64026 100360940 63879 287606 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223931 Ionotropic activity of kainate receptors 58948 553106 24244 298521 24407 24406 54257 29559 29495 25252 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME DATABASE ID RELEASE 96%10225227 Biosynthesis of DPAn-3-derived maresins 25290 287454 HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones 303470 680498 83724 679713 296501 26295 310678 310194 360642 24829 316328 297597 299305 303175 64627 81647 303514 317464 306571 363292 83712 306945 310352 300206 688634 362093 311575 315210 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 96%10224609 Repression of WNT target genes 29382 84424 25565 161452 81717 312451 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 96%10222947 Cyclin A:Cdk2-associated events at S phase entry 84389 29414 362485 308937 83571 287772 366275 292766 64156 94201 29669 171102 29668 29425 100360846 499655 307585 117263 25581 29666 303353 365388 117262 85492 24708 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 114494 287280 100912032 171103 24185 25233 266713 58919 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-RNO-72702.1 Ribosomal scanning and start codon recognition 292762 682390 298700 25348 691947 362952 81775 81776 299872 81773 81774 293427 288599 303831 299027 54318 65136 691531 27139 296302 288516 294282 122799 29236 681429 117053 100362640 64156 161477 292148 100361756 29288 29287 29286 29285 299899 124323 140654 29304 140655 29284 300069 293484 103689992 122772 117045 29258 83789 94266 108348073 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 96%10221951 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 83571 295052 362485 114494 314818 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%10223551 Transmission across Electrical Synapses 362979 50564 315435 266706 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%10221971 p53-Dependent G1 DNA Damage Response 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 81827 83806 362485 311078 304798 192255 114494 100912032 360860 114212 83571 287772 292766 64156 685474 29669 29668 300711 29425 100360846 117263 25581 29666 303353 365388 117262 85492 311575 24842 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%10222247 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 79239 24511 64665 114562 83764 301007 311721 307016 292756 304007 366492 304546 315686 171581 305645 140922 114612 29753 306464 679342 287624 291441 257649 29448 257644 64041 25448 94266 29489 363028 25576 25578 315164 25577 304951 289150 84589 361416 363174 81655 303037 307511 363059 114764 29564 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 367915 287598 307805 311191 29648 500545 102555739 295661 313017 65201 681185 363235 308443 296137 24264 317252 305270 83572 140734 681050 58945 684439 81745 117273 302855 29495 29417 24255 117259 84353 313050 303251 303811 83721 81679 83502 498798 301252 311030 100360623 24208 56084 25513 170911 60664 83709 316369 114559 29433 363875 299331 294429 287830 292085 299809 500569 316226 50646 297522 81738 683983 366608 313438 171041 25522 305987 315992 317598 360678 313388 117550 171549 314906 54350 65134 64351 308875 503165 116666 64373 65032 94195 287876 306618 66013 25023 287537 287418 84009 120099896 310635 311647 310999 78966 117020 309653 303634 301334 363460 293024 100362710 362648 295378 298404 83615 310460 307098 246174 363509 140898 361921 304109 310192 687105 29491 64678 170824 24392 54241 315840 309175 313838 64465 363445 25437 25270 85428 307170 65183 363009 81732 308761 304282 29146 287746 307562 500246 56785 64160 83809 259242 299857 64630 289820 306417 498174 308509 192348 309722 679934 293497 81531 305457 315265 116717 500287 192207 365355 305341 297518 360915 308968 685357 79115 315348 297406 295588 315121 29579 25097 288669 64515 66021 306506 312077 306871 297176 84031 117955 300067 114592 300186 360849 498331 313024 360840 303583 367235 361813 305605 117538 192277 117542 360854 303553 83724 287543 25515 310090 116685 498547 360500 304530 303888 114004 81824 116670 362938 303653 81818 114116 58823 313216 114243 362566 54227 79129 500929 315732 305938 63994 362842 25230 24874 690130 304813 291694 310013 60377 315829 300111 362988 315648 302976 291755 291999 311450 298144 25306 363131 89816 362993 81522 246314 312667 311793 308021 360596 65052 289229 64303 363193 299145 309362 29611 84014 309179 295635 678766 24673 286928 307035 261736 79249 317296 294568 689997 367902 24672 367901 25594 292279 688319 117281 313934 117039 116590 300838 29745 24244 310519 170538 113960 306152 83425 84510 501099 25488 308666 306004 362271 315707 682937 24680 287156 309168 192647 171086 116478 497974 29528 314850 309922 312754 114513 362859 316213 299147 56011 24669 310678 302783 24829 24828 117056 685909 680615 365407 303175 64627 304893 116547 306970 300115 303501 100363276 296323 309696 297383 310833 306183 78967 362279 312113 29275 314249 306945 312108 83620 296060 293860 308097 306357 360942 363031 311860 680498 688429 362456 361882 314618 365877 305234 367085 300225 81634 303611 314903 305367 54308 316639 303222 690795 498282 361940 60431 361029 171296 360509 291000 290396 503306 366170 299012 314212 29355 363213 293947 306279 246249 312640 29681 362893 679082 288093 307459 305156 306400 498130 310074 25537 296162 25096 310621 300030 313618 361617 56010 116643 308869 301555 300955 305614 64159 81504 25614 81822 313845 50689 288057 24852 29431 171115 29432 84427 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%10224429 Anchoring fibril formation 365460 678743 301012 83470 RHOBTB3 ATPASE CYCLE%REACTOME%R-RNO-9706019.1 RHOBTB3 ATPase cycle 309922 362566 65032 301555 84589 56084 24874 367915 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%10222687 Dissolution of Fibrin Clot 25692 24617 681544 60325 29366 81778 291085 85253 56611 50692 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 96%10222211 The canonical retinoid cycle in rods (twilight vision) 25056 25703 24717 24856 353252 363071 64047 266761 293049 314264 24711 266714 89826 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 96%10224877 Events associated with phagocytolytic activity of PMN cells 287610 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-RNO-110328.1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 367090 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing 81736 24493 290257 309452 29197 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 96%10223633 Alpha-oxidation of phytanate 65183 65192 114209 113956 85255 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225181 RHOU GTPase cycle 313934 64465 300955 56084 498282 50646 25513 305614 64159 81504 363445 288093 83709 291999 316369 363509 114559 310074 301007 29433 498798 292756 366492 304546 315686 54241 305645 140922 29431 678766 315840 360840 29432 311030 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle 25558 140592 24398 84556 25012 116470 25531 24803 192268 84012 29642 29483 29482 366432 25716 64830 293645 116638 66028 64832 25550 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-RNO-418555.1 G alpha (s) signalling events 59075 50678 308776 140928 309962 25387 24627 25388 25638 63885 25238 293508 29699 25521 25372 29691 29516 81743 24511 25725 24679 85385 RHO GTPASE EFFECTORS%REACTOME%R-RNO-195258.1 RHO GTPase Effectors 25594 292279 117281 25023 116590 24208 24244 170538 501099 308666 682937 24680 29433 363875 312754 294429 287830 299147 56011 292085 64465 24669 500569 316226 310678 302783 24829 24828 297522 81738 683983 117056 685909 680615 171041 25522 303175 29753 64627 306464 679342 287624 116547 291441 306970 257649 257644 85428 64041 25448 94266 29489 363028 297383 25576 25578 315164 25577 117550 171549 304951 289150 361416 314906 363174 306945 83620 81655 303037 293860 307511 363059 311860 114764 680498 29564 286993 114514 365877 298850 83836 363198 300225 362548 304477 298594 81732 308761 170845 252902 85252 690795 287746 287598 307805 361029 311191 29648 500545 259242 102555739 290396 289820 295661 313017 65201 314212 681185 29355 679934 308443 296137 81531 317252 308875 305270 83572 140734 681050 297518 58945 684439 81745 79115 315348 25537 310621 300030 117273 288669 64515 56010 66021 297176 114592 360849 313024 360840 29495 29417 117538 24255 117542 360854 83724 25515 300955 114004 81824 84353 116670 64373 58823 114243 79129 54227 94195 303251 303811 304813 83721 81504 60377 25614 81822 302976 315648 83502 50689 298144 363131 288057 311793 65052 64303 363193 29431 309179 286928 24673 287876 79249 29432 294568 100360623 367901 24672 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 96%10224557 Cellular response to heat stress 116590 171361 59102 309757 292887 25400 24245 24246 299331 116643 294429 24468 56718 287830 291874 362281 84027 171140 113975 64226 292085 79245 295692 24472 117021 362335 366016 58958 362557 65274 113929 297522 245922 362809 81738 260321 683983 53372 25497 499974 25617 24963 29753 291671 60460 266759 116456 25420 50689 307997 293103 286899 362293 81800 500907 288444 297994 307133 311427 301252 366734 113906 293524 29734 690038 289014 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 96%10224913 Signaling by MET 25532 170921 56084 25513 170911 24511 54245 85385 361388 64156 116743 691517 363875 83805 24553 295347 309816 24446 500985 360606 25622 117063 50522 24697 24605 287942 192255 293621 100912032 79121 313474 81504 171337 25614 24525 313845 81922 25125 296121 498798 81921 364686 313388 311331 360658 303517 292770 361396 312574 29135 311030 50866 84357 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 96%10224897 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 58936 301513 295707 287249 316034 363603 83722 363221 29619 306492 291841 307511 312227 25498 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222079 Propionyl-CoA catabolism 687008 291939 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%10222279 Transport of small molecules 79239 291437 24530 64201 58976 24539 54281 503568 24170 58980 25240 54231 29242 300027 310218 24440 360504 65207 24779 298203 114766 171015 365345 114613 360670 117267 306866 65133 25293 25132 25386 29504 81830 25246 24153 287979 288707 114506 303070 500132 361069 305131 299714 305135 679906 499287 362053 303796 79430 83470 83810 171433 353231 303056 140933 365567 79425 64198 292168 192675 29465 65054 66026 689991 29233 29232 293048 286758 295462 50676 81782 367316 367318 25749 304315 64673 365266 171497 360932 171496 304203 315218 266732 361929 266730 502970 306600 100361444 24768 24767 305886 25400 171143 24245 171384 24246 295041 114246 311396 301111 114507 311287 114629 266770 64037 29172 170566 29171 293735 314637 171140 288026 360539 291555 24255 361986 296578 64831 63866 63997 295245 314401 25239 293874 311387 63882 294281 116469 84550 25688 498185 313771 29485 303856 29484 24217 192215 312896 363024 289443 65039 290673 291582 301418 362861 362642 362188 299488 85426 314847 252854 362645 140944 291411 170573 294930 24703 294341 364601 29464 289594 311204 286920 309131 83514 85333 497948 366432 361586 84484 364973 64522 79123 192208 308015 501925 294329 25550 79032 25552 295669 310808 293485 362403 688685 289459 246215 295455 117152 29440 689103 117240 291470 363985 24171 294255 307350 314396 311846 114511 362247 84012 25480 65194 25241 289353 25122 266998 25364 296969 308668 311651 308667 170840 292597 171135 363120 85254 310625 680602 85256 498910 56814 252919 155205 295645 287478 246235 24784 246239 24783 246280 297386 117261 24780 24782 116642 24781 83500 365398 305540 266612 291733 295417 317170 303205 315311 29642 304784 25490 304785 315439 171147 60423 25176 54302 54301 85267 287532 65202 305846 314441 29502 29509 311168 29743 301010 89776 299027 54318 25715 300051 296302 353307 94106 297910 64018 81826 29726 310732 306009 29735 25139 311839 363115 64672 24211 24212 24213 294141 689560 63847 312981 63848 58950 58971 64190 116831 58851 59299 29639 29132 25292 680551 89821 313210 24186 64310 287276 25649 25506 80878 25728 292697 54225 310900 25080 25081 315272 308637 25108 116601 116726 29599 29598 29693 307811 65200 25073 50655 29715 84551 50567 114628 116721 24891 85493 286970 303639 60395 287788 304805 79248 81642 302395 299609 63886 314537 140447 140448 300664 362302 301482 155192 140669 25650 83509 50719 24221 297932 298103 29757 289407 362802 170924 368044 25027 296981 298451 299971 83615 170667 436582 25391 297566 25390 312488 117596 94170 116664 29600 366545 24825 499991 64678 170824 83800 29199 288562 54241 140638 116563 691209 29501 54300 308069 83629 171373 170698 246234 140915 58978 84511 140860 259248 432363 298296 24451 25270 116548 84356 83519 363516 287772 65046 292766 64156 29579 140670 29669 29668 29425 100360846 117955 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 297930 140668 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 25230 287280 100912032 64199 79218 245986 60449 293508 306825 25344 294962 25521 25725 24679 83579 680149 65142 58979 24244 114117 24400 81667 29699 24778 29483 116509 170567 266767 29482 24904 113918 664630 25553 29503 24898 116638 79212 171148 83612 298340 79213 309111 282712 117100 83511 681896 171163 84487 302973 25551 170551 25548 314459 84395 303333 83535 25560 80848 25507 24941 316519 59108 170520 85382 362850 50662 170496 363103 294698 313139 299903 289874 290783 116967 290823 407784 116643 362891 690315 360967 170943 29292 312382 300438 25303 25319 24565 TGFBR3 PTM REGULATION%REACTOME DATABASE ID RELEASE 96%10225439 TGFBR3 PTM regulation 116510 29610 29543 81751 300802 81707 29192 65205 292788 289231 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%10224301 Resolution of Sister Chromatid Cohesion 114764 29564 117281 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 363481 305270 83572 140734 681050 58945 684439 313304 64515 63996 297176 312754 114592 54237 294429 287830 498265 299147 292085 25515 684771 305343 304218 290577 24669 297522 25203 81738 683983 315648 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363193 363028 309179 315164 24673 304951 289150 361416 363174 81655 303037 363059 24672 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 304798 192255 100912032 360860 114212 287772 292766 64156 29669 29668 300711 29425 100360846 117263 25581 29666 303353 365388 117262 85492 311575 24842 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis 117106 54225 313934 117039 361244 361120 24803 117277 60422 317396 56084 81645 60568 311854 25490 60566 60564 24221 363466 25372 25716 25108 29528 192152 25433 360915 25313 65046 64156 24180 116743 24825 64558 140670 64678 312689 29491 25151 83800 116561 85491 54241 79128 116563 83730 24329 29216 500985 24255 25387 25388 363273 363266 24805 50522 363283 300678 65178 25710 24932 303251 114590 24807 192255 298598 100912032 290639 292944 313474 59325 81504 29183 287367 266606 314349 81922 89816 25238 64022 498798 81921 85256 312694 360202 261736 24827 300438 311030 84357 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis 301005 287420 295088 81643 288259 362329 684425 315150 117544 289276 140946 CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-421270.1 Cell-cell junction organization 81736 301334 304109 54281 363875 305679 64465 297893 500569 310678 302783 24829 24828 117056 100361294 685909 680615 303175 25697 64627 306970 25507 689820 26955 81650 266758 314641 360652 29144 362279 25066 361866 498515 306945 81717 116479 310174 192248 85489 83501 680498 84430 304297 308417 365877 688673 116549 362850 117048 316639 690795 313806 60371 192183 360687 303068 25705 498281 301887 84407 29181 307237 497229 300445 300289 81918 293142 290270 361432 363058 25409 29606 24790 78947 84006 309757 287772 29163 292766 29162 64156 293721 29669 360882 29668 362040 83805 29425 100360846 29382 83712 117263 192275 25581 63879 29666 313048 100188932 303353 365388 686092 117262 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 29676 29675 84353 50522 81827 83806 311078 24514 192255 100912032 313474 292064 81679 25150 500870 50654 25751 311163 83502 25125 83427 24498 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-RNO-9958863.1 SLC-mediated transport of amino acids 305540 29485 29484 29642 83509 50719 315439 170573 287532 29464 29483 170567 29482 113918 314441 366432 664630 311168 192208 50676 25550 116726 298340 84551 50567 282712 84012 252919 155205 246235 170566 307811 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223857 Hydroxycarboxylic acid-binding receptors 689936 353250 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 96%10221943 Removal of the Flap Intermediate 59294 84490 85241 361698 25737 301323 59102 289758 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-RNO-9975921.1 Assembly of the 9+0 primary cilium 117281 363272 171044 64158 311573 311802 311529 290626 365153 300963 362553 315423 296618 170714 683722 314523 29479 500086 363055 299209 100910342 305467 24818 366403 685284 298767 64632 367153 288305 360672 300062 308064 363544 294864 373066 365770 252921 311123 316102 499814 314961 304007 293844 60627 100362495 295230 316531 288585 300675 171455 296554 85258 500571 24650 363286 310344 116654 287541 313365 252881 314787 363760 498095 60347 50556 246150 295106 29214 363126 299331 500069 361789 113948 29213 245709 81740 192228 64664 25411 307347 305882 500832 315484 311456 29374 299246 114089 362142 679894 305287 367714 299809 287612 361930 65209 117103 307724 100362124 305349 303968 295654 116475 289168 689779 312651 366872 503018 308923 362265 680407 287383 300880 85248 303915 293148 296136 313170 287836 117515 361727 266809 29753 309486 81830 29489 29885 309451 114764 79120 83836 299850 64462 311191 308443 83572 140734 58822 58945 24717 56010 54237 29167 294010 83567 25515 25273 24679 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225345 RND2 GTPase cycle 303553 287543 65183 363009 362938 361029 29648 25513 299012 192348 293497 116478 315829 192207 291755 306400 310074 301007 314850 312667 64678 366492 306506 289229 312077 305645 140922 360849 302855 498331 362859 316213 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases 291555 29132 24244 303856 24217 25650 290673 303056 362645 291411 116601 25391 25390 365266 360932 29600 171496 29599 29598 361929 64672 24211 306600 24212 24213 24941 29693 25400 63847 24245 24246 63848 311396 58971 64190 116831 288026 29639 171140 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%10224487 Nuclear Envelope Breakdown 113975 299204 292085 25023 114087 295692 25515 116685 117021 362335 366016 58958 362557 65274 113929 24680 297522 245922 25203 81738 683983 53372 25497 499974 25437 54237 294429 316737 287830 287447 291874 362281 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225195 Miro GTPase Cycle 287156 192647 171086 497974 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) 100910143 287159 364032 378774 315807 288041 366478 192263 362756 29640 79112 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%10222173 RNA Polymerase I Promoter Escape 680498 362728 83582 690450 83581 365877 84389 288651 297093 361580 25574 502227 294693 690795 310678 83503 302783 690966 24829 24828 291703 301246 498109 117526 117056 685909 680615 303175 64627 306970 266713 304714 361784 360893 361420 306945 313245 680493 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%10224981 PTK6 Regulates Proteins Involved in RNA Processing 366275 117268 170843 64015 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-RNO-5389840.1 Mitochondrial translation elongation 301250 301371 364656 287302 293666 114017 296134 64360 303685 113958 294767 684304 680747 301352 290850 297372 301240 498406 303746 295238 293054 309176 298517 293754 297799 361883 363023 301552 299628 497876 683519 288916 294230 309140 100363539 360594 500199 299938 292758 287962 295224 296551 171061 292244 363646 689432 361005 310653 362216 297601 56281 309440 287656 297459 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%10223873 Synthesis of GDP-mannose 501167 300741 302915 300089 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%10225009 TBC RABGAPs 292886 303734 317580 64862 501854 25532 313234 24855 117103 363123 361697 499768 84379 311911 361227 360827 79121 60445 287110 365372 29448 81830 246294 79434 58974 366896 64670 360956 288700 365793 266688 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223785 SIRT1 negatively regulates rRNA expression 680498 303175 365877 64627 309757 306970 690795 310678 302783 24829 24828 117056 306945 308911 302553 685909 680615 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223611 Vasopressin-like receptors 25504 24221 25342 25107 25108 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223439 Laminin interactions 302248 81008 24511 691517 309816 MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 96%10224991 MET activates RAS signaling 24553 24525 364686 313845 24605 293621 361396 85385 24446 81504 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-RNO-879415.1 Advanced glycosylation endproduct receptor signaling 691149 493810 54226 25742 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225389 Regulation of CDH11 gene transcription 24790 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling 25326 25746 116562 24918 25126 85385 25704 313050 25155 50646 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222309 RNA Polymerase III Transcription Initiation From Type 1 Promoter 246299 690254 685539 306012 83503 690966 301246 294687 498109 362095 117526 114205 316810 311487 310685 361102 685465 313914 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH 89809 289508 64156 50522 292101 84478 140639 316235 192255 116643 288003 25737 100912032 288414 59102 116468 INTERLEUKIN-38 SIGNALING%REACTOME%R-RNO-9007892.1 Interleukin-38 signaling 362077 171106 116554 317553 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190375.1 FGFR2c ligand binding and activation 29349 25444 54250 25317 170700 29369 29368 60464 170583 116499 60662 25022 66017 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176814.1 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 287984 65138 94198 25515 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 25203 83806 311078 192255 114494 100912032 360643 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 29666 54237 303353 365388 64193 117262 85492 288671 290875 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%10222387 PI3K Cascade 25444 25443 54250 25622 29369 83504 29368 170583 25513 170582 246273 29516 60662 170911 361992 84477 170579 25022 85243 66017 81504 29349 29348 84489 25233 29376 81745 361388 363131 170700 25317 314850 289625 170633 65052 60464 25467 79114 116499 25114 RHOBTB GTPASE CYCLE%REACTOME%R-RNO-9706574.1 RHOBTB GTPase Cycle 114612 117039 300838 301555 117259 299809 81634 306004 81818 313216 309722 315265 365407 81822 360915 308968 114562 25537 297406 360596 301252 140922 171115 315840 302855 299331 261736 361813 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%10223773 Arachidonate production from DAG 305795 499913 309207 29254 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%10224759 Phospholipase C-mediated cascade; FGFR2 29349 29348 25444 25443 54250 25317 170700 29369 29368 170633 60464 170583 25738 116499 60662 170579 25022 66017 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%10224449 Establishment of Sister Chromatid Cohesion 684771 680014 691979 305343 304218 290577 313304 63996 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-RNO-170822.1 Regulation of Glucokinase by Glucokinase Regulatory Protein 113975 292085 295692 117021 362335 366016 58958 362557 65274 24385 113929 297522 245922 81738 683983 53372 294429 25497 287830 25658 499974 291874 362281 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-RNO-68881.1 Mitotic Metaphase Anaphase Transition 292263 25515 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224821 LGI-ADAM interactions 116470 140729 84347 24923 140724 305417 252892 140725 29495 57033 306013 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-RNO-983695.1 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 499356 361618 308501 89821 313845 300955 294048 81678 116689 29337 25513 366508 25679 25262 100360919 100913063 25155 81504 362046 84357 367901 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10225283 Assembly and cell surface presentation of NMDA receptors 24409 24408 24410 191573 24412 24411 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade 289395 303861 445269 113936 155012 24233 406161 113959 298566 24854 24232 29687 365466 362634 295703 54243 79126 84007 117512 29333 312705 100360919 299606 192262 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-RNO-5610780.1 Degradation of GLI1 by the proteasome 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 287280 361765 100912032 287772 361769 292766 64156 29669 29668 140589 29425 100360846 311567 117263 25581 29666 303353 365388 117262 85492 RAS PROCESSING%REACTOME%R-RNO-9648002.1 RAS processing 24525 65142 363272 24244 361171 25318 309399 25514 361601 170818 309153 299617 302808 25523 24888 24605 293621 64511 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224159 SHC1 events in ERBB2 signaling 117255 29340 25433 25313 170538 498596 64022 24680 24329 432361 29496 85385 59325 INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling 500538 116590 170538 50689 301442 117063 300772 116689 25400 24245 360697 24703 24246 116465 25712 24514 89829 171140 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%10224845 CD22 mediated BCR regulation 116689 308501 81515 100360919 100913063 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-RNO-5693607.1 Processing of DNA double-strand break ends 290805 308755 497672 64557 83508 363924 303194 315969 290997 64046 290631 316794 171366 85482 59102 192218 298534 287927 685055 310034 25573 361815 306734 305000 499417 300711 299638 690043 297627 296099 360588 497856 64012 294800 498411 308669 295052 291787 289468 100361529 297486 140583 362827 24829 362704 288003 114494 288414 116468 303175 64627 116725 306945 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-RNO-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 59294 81685 81709 361698 25737 305000 59102 289758 RAC3 GTPASE CYCLE%REACTOME%R-RNO-9013423.1 RAC3 GTPase cycle 292279 688319 362456 287537 305234 310519 306152 305367 304282 311647 29146 308666 361940 307562 25513 64630 290396 299012 308509 64351 679934 24511 83709 29528 307459 306400 310074 315348 304109 310192 315121 292756 29579 64678 366492 66021 304546 116666 300186 313024 360840 308869 117542 64465 304530 58823 114243 79129 63994 362842 302976 25437 29448 311793 100363276 317598 309696 29431 295635 78967 286928 307035 79249 312108 29432 294568 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-RNO-446652.1 Interleukin-1 family signaling 315599 500900 113894 309157 114495 116596 116554 362418 308267 291861 317546 81736 25493 312688 25466 301059 117022 54226 24493 362077 309361 300177 171106 361677 303024 303604 314870 60582 317553 311783 296541 84388 287772 499744 292766 373540 64156 301365 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 361749 29677 29676 29675 50522 81827 83806 311078 192255 287280 361765 100912032 29197 25125 25742 116725 290257 311245 309452 309295 310877 25556 363520 291921 64044 313121 299827 287707 84351 305549 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%10222627 PAOs oxidise polyamines to amines 308652 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 96%10224235 Acyl chain remodeling of DAG and TAG 29254 362972 678749 361676 302425 84497 252900 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing 366276 500538 300208 501926 292778 288588 287530 687711 316123 689116 83503 298075 494445 361365 690966 100362099 117017 681031 292019 295270 363633 498109 289561 362687 171365 680737 291060 689890 363082 360803 691538 680891 302670 303607 291794 362990 84486 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%10224037 Spry regulation of FGF signaling 117281 116590 50689 25622 64156 50522 83805 114486 500526 306141 24673 192255 100912032 500985 81504 24672 REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA 79213 171163 50676 79212 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%10223287 Negative regulation of the PI3K AKT network 117281 116590 25444 25443 54250 29369 29368 25513 497932 170583 25466 301059 170582 246273 300177 366508 29496 170911 361992 60664 170579 84477 85243 66017 29349 29348 84489 25433 29376 25313 361388 298947 25317 497931 314850 363875 170633 29149 24553 312754 79114 24329 24446 299147 25622 498596 24890 83504 25149 60427 60662 29613 81737 25267 25022 25266 59325 29183 24185 24629 24628 25233 170700 64022 289625 60464 314641 29414 308875 24506 24505 83805 309419 361749 50557 313050 81504 25150 315648 50689 59265 311245 294048 116723 25660 89812 294235 25556 363193 363520 24225 25467 309179 116499 25408 432361 24673 64545 64030 24827 56822 25114 25730 25054 365865 140607 24672 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450408.1 AUF1 (hnRNP D0) binds and destabilizes mRNA 287984 65138 94198 24472 29673 29671 29670 29677 29676 29675 50522 81827 79256 83806 311078 192255 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 171350 29666 303353 365388 117262 24468 85492 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 96%10223073 Signaling by VEGF 315994 25023 24244 170538 29414 314612 94203 83785 308666 114110 114111 362271 89811 682937 25589 24680 360457 25513 25738 246273 170911 679934 361992 85243 54245 295378 29302 296456 316369 81745 25676 315348 25537 29433 363875 117273 83805 81527 66021 362513 310688 246331 299331 313024 56718 117542 64226 64465 300955 84353 50646 25414 58823 79129 24605 293621 25522 25614 24185 81679 24525 25150 25233 311163 24600 315189 170897 296648 293508 310131 29431 286928 60352 79249 29432 360820 294568 289014 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes 294279 25412 25654 362584 315979 114200 362285 367313 84352 363158 290637 83470 84032 363458 288583 365460 678743 306628 287899 290905 685612 301012 305253 85490 315071 29569 353303 499431 314981 312115 289081 60379 25681 29345 304021 25506 288016 64367 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 96%10224849 Gap-filling DNA repair synthesis and ligation in GG-NER 59294 89809 298098 64156 299112 50522 362385 192255 288003 361698 171525 304573 25737 100912032 288414 59102 289758 116468 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-RNO-73857.1 RNA Polymerase II Transcription 290805 308755 497672 114495 64557 24484 308986 363924 303194 315969 25242 64046 25243 85482 304809 59086 192218 114212 685055 310034 25573 306734 54281 301442 305000 300711 297627 360588 497856 64012 294800 498411 291787 24855 100361529 140583 363064 24942 24185 60445 29753 25233 685474 25576 25578 25577 313131 307511 311575 29414 313017 304798 686980 58936 81745 304832 161452 83805 302415 29417 312451 300837 116700 50554 291534 25329 314993 25631 84353 288003 25737 288414 116468 292064 115771 681062 24577 81516 116484 29357 360471 60331 24208 24705 685072 25682 58851 64466 304758 362479 192350 84578 500715 687711 683469 81785 306998 25149 100362099 362110 294515 681031 25154 365755 302711 171365 680737 83574 60349 289372 171068 406162 306571 363292 365155 315210 292778 679713 288651 288588 361580 316123 689116 502227 294693 83503 311796 298075 361365 690966 117017 305455 679203 291703 363633 498109 289561 24398 304204 362537 192268 361374 64314 25309 170824 690675 84482 26195 26198 363445 293184 50659 81920 361531 363481 303539 687001 297453 362981 689844 56761 310405 363287 113898 679028 252860 84580 102556092 303101 287772 58839 292766 64525 64156 316034 140923 305025 29669 102553962 29668 296102 259241 29425 100360846 58850 58853 102547287 117263 65035 25581 686781 114592 305120 29666 54237 58983 303353 140942 365388 108348224 498160 117262 690728 85492 102555083 303393 60351 54278 282845 287984 365224 65138 295448 286979 94198 100912096 303281 29673 295052 299810 29671 29445 29670 303132 29677 102548695 29676 286996 117254 29675 114510 291773 50522 293044 317256 83828 29338 83722 361831 170844 81673 102549410 83830 303226 306977 171152 81827 102555289 309638 100158223 288533 685619 25203 373541 83806 364298 293345 294018 102546572 311078 307839 192255 303918 102547413 117526 114494 291841 287571 100909569 94194 100912032 299694 299210 681024 84396 266734 102550851 114208 315648 314586 315427 287361 306966 81807 287249 24522 25735 78972 102555170 300197 306816 365192 306817 304514 81808 313596 24673 502988 171335 245980 266787 300813 102546648 288514 298558 298681 24672 100188937 362045 54322 499874 117281 499994 367034 116590 140908 266774 298688 500108 502894 114491 171355 116671 362813 114490 305837 301119 683593 313219 291705 360764 100360287 24377 24370 680200 84683 361988 360896 293625 312227 102555672 287076 156726 311591 314862 84469 292804 120095871 289382 313777 287094 295707 134478826 310233 297065 363603 499929 691379 498952 293701 102556967 100362678 297066 312303 313757 360229 498945 360589 291772 102553002 25405 311546 314818 24842 300782 494339 499900 301513 25591 500855 56011 293615 25533 309002 282844 64033 313978 25622 685925 293849 691504 297893 308362 362675 654441 24890 688328 310678 309457 307151 252917 315606 100364132 302783 691610 24829 291164 24828 311414 303518 170955 296732 690895 100362634 25282 25193 308582 313038 497923 304690 361487 117056 100362083 309626 246334 363014 291877 29657 685909 311670 117274 501688 680615 60661 288563 311166 680717 25720 299256 100364568 310258 102553866 365407 361925 314417 100365779 303175 299811 306261 116697 303730 362358 304277 25697 308561 366468 64627 308320 295384 289582 308326 25172 365744 683927 60421 308322 301164 246279 306970 688386 304794 311613 266713 361391 691422 315136 252924 83833 363221 689820 681178 311567 120093538 81650 313507 363227 500453 100365683 361825 499068 290829 362272 58919 29619 361944 286917 100359816 306492 306945 361057 297867 690559 25159 246264 362093 100362170 102550344 252934 501403 311860 680498 301020 171046 365877 116549 84389 85471 114483 29175 309001 50662 690795 362485 59102 100360427 24790 83571 290744 309757 24413 25747 680111 65248 361178 56010 83712 24873 497991 25664 295357 64562 313048 314621 26954 117535 117044 117043 83826 290669 56718 362834 116698 360776 25520 83803 300320 308869 287662 310091 298514 64226 373545 688041 25672 297960 310614 361724 84385 297093 24666 81812 78975 25498 50689 315189 313558 690516 296648 116723 89812 310131 79240 140607 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%10225383 Regulation of CDH11 Expression and Function 81679 303068 24790 84407 311163 362850 300289 84353 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%10223827 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 57341 170922 24511 360820 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-RNO-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 290027 59294 89809 362600 84490 298098 25591 79116 83507 29240 299112 362385 288003 361698 304573 25737 288414 59102 289758 116468 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-RNO-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 29611 29711 25244 298942 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222097 Tyrosine catabolism 29383 29531 681913 24813 DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 96%10223161 Digestion of dietary lipid 25680 117554 50682 84028 25702 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-RNO-9758881.1 Uptake of dietary cobalamins into enterocytes 29319 314459 80848 SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-373755.1 Semaphorin interactions 140908 116671 316639 64373 296789 65208 78966 313498 306790 312213 316009 310630 361568 25418 309280 311384 25415 25417 315711 361597 363517 29751 289392 361537 25150 306400 25537 29433 362993 25416 363875 117273 24699 24553 246331 301252 314641 29431 299331 29432 310207 84027 SUMOYLATION%REACTOME DATABASE ID RELEASE 96%10224493 SUMOylation 308755 497672 24208 25493 297561 25573 301442 499417 690043 24705 296099 294429 287830 58851 291874 362281 113975 292085 25591 295692 308669 117021 362335 304157 297893 366016 58958 24890 307151 362557 65274 362827 113929 297522 245922 81738 313038 683983 25154 53372 309626 25497 499974 304132 310258 308384 303730 103689978 25094 64627 78973 690244 690251 60349 64041 501403 60373 500545 363287 290744 64550 24413 25747 313304 361100 299957 367846 63996 313961 300772 29382 691688 24873 291171 117287 114592 313128 363269 361645 293528 102551929 315133 83826 501145 116698 64520 60351 300320 303310 287662 310375 83422 688041 25672 316164 83614 84385 293967 81812 24874 25737 117282 25498 309452 309295 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins 81639 25290 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-RNO-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors 54225 362862 25081 24791 58917 503164 117254 24186 312701 315111 25377 25073 299858 94195 360922 24440 360504 64202 100360919 24464 25728 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-RNO-9634815.1 Transcriptional Regulation by NPAS4 266734 25242 84469 25243 29657 NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism 297508 353255 315085 295229 313241 298653 361751 363118 100125370 289095 365699 499330 316062 25668 81506 367323 293504 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 96%10221983 Activation of ATR in response to replication stress 498411 100361529 295596 363924 312538 140583 360908 316273 296178 313479 291927 307126 288003 360621 59102 288414 116468 29728 312046 298534 685055 310034 301430 288532 313138 171102 307511 294800 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10222083 Fatty acid metabolism 679520 114097 140547 113965 84013 117182 24307 290623 266674 117543 24158 502969 24886 298423 25527 313375 25526 286904 59103 24306 29224 404280 299566 503122 50671 312086 25413 25756 25757 361992 84024 50549 29726 287454 687008 29527 29328 29624 81639 29277 299732 24296 24297 65030 25290 25682 291939 29470 60581 308518 291075 25426 503049 362809 25541 85255 311849 315973 246074 50559 498790 171410 83512 289125 296851 94199 171402 307092 171400 310848 291283 359725 79244 170465 361266 25288 171516 25045 307096 361802 303577 364773 50681 291984 498789 266604 191574 361895 498728 29411 84575 309449 170570 113976 26759 114209 54398 364134 113956 100363074 29510 114024 307170 24159 85239 94340 84029 117243 25363 65183 300783 619561 64461 287424 64304 287425 100911581 24404 680115 301120 191576 363516 314304 83842 83522 501072 65192 171142 64562 373545 78975 116568 29566 58962 25287 171155 170670 293453 24565 289014 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-RNO-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) 78968 300095 84509 89842 301024 24917 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina 116685 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-RNO-1280215.1 Cytokine Signaling in Immune system 315599 315994 500900 113894 309157 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 25466 301059 116663 117022 54226 24493 309361 300177 60587 361677 303024 303604 314870 60582 25402 498416 301442 54281 85491 24468 25216 89829 500985 682457 24697 498951 25613 81802 688621 29197 24185 25233 641452 81920 84492 25578 500538 116470 24803 29414 295704 64624 117553 313017 680609 290655 84405 171334 171333 689932 24917 365368 155140 317553 287772 292766 64525 64156 81515 29669 29668 29425 100360846 117263 25400 25581 24245 24246 29666 54237 303353 365388 117262 85492 171140 287984 65138 94198 29673 29671 29670 361749 29677 29676 29675 50522 313050 361831 81827 24932 360697 24703 83806 116465 311078 25712 24514 192255 287280 361765 100912032 114558 25155 25734 315648 81807 290257 24498 363193 25467 24673 299827 311130 292892 311430 363006 25489 24672 117281 116590 170538 24835 25625 25704 171081 65038 116689 25513 25326 25746 362077 25738 116562 366508 171106 116630 54259 170911 60664 84477 85243 54245 85385 64511 25012 311783 29376 296541 84388 25318 499744 373540 301365 312754 24842 24472 25622 361810 24918 25126 365769 690369 310678 116558 25670 50646 89817 24391 24683 25235 24684 294515 359726 120103159 298205 287942 502959 100361294 298210 24481 686326 120103158 100911527 690894 305896 288264 170897 29144 25506 680498 25069 683163 25341 89814 353218 302424 500910 171369 361795 100911249 498666 360548 25325 252878 60371 362629 362628 156767 500836 117516 310132 25008 84349 313173 688622 500592 29201 500590 365581 81680 681112 296872 444986 360640 25572 685840 25707 498769 245983 304091 289747 170819 300772 310968 81803 81804 300955 362678 117063 314172 362050 24667 54287 306231 691105 84472 171164 304859 63880 499155 81746 24605 81635 298693 293621 304266 306204 304545 291978 24649 29219 81504 25498 24963 24525 501552 25084 25150 81822 502320 81646 287287 362862 313845 60460 303742 116553 25125 50689 500616 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 25556 363520 291921 64044 362788 313121 287876 362491 287707 363855 25272 84351 24516 289014 305549 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 117281 501582 100125373 83789 287522 365215 291434 259170 81729 25347 28298 307503 64205 26962 94266 24420 100910714 287596 64298 287113 290641 691397 298385 361923 134480579 117042 689116 287122 499782 117104 298075 360855 140661 140662 295284 29257 25348 300079 292964 81775 313449 293418 81776 81773 81768 81774 100361974 684558 65136 362631 691531 27139 294282 360572 122799 245981 29236 681429 497860 117053 81770 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 140654 81767 688288 81763 171350 29304 140655 29284 100361060 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 361109 361271 690303 24672 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-RNO-174113.1 SCF-beta-TrCP mediated degradation of Emi1 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 292263 83806 311078 192255 287280 361765 100912032 287772 292766 64156 29669 29668 64515 29425 100360846 117263 25581 29666 303353 365388 117262 85492 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins 310738 54281 25507 116548 TRIGLYCERIDE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222301 Triglyceride metabolism 25598 64822 79131 25062 79223 362732 296130 681211 29653 80841 84497 140868 252900 25440 316737 499570 24360 300108 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway 362383 64524 362706 24689 100360180 24377 29562 501157 690945 287479 314140 83688 DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions 25528 81511 313050 301229 25513 25738 24605 293621 170911 85243 85385 295378 25155 361537 81504 24525 25150 313845 366962 24223 363875 29337 292844 24934 29684 679787 25110 498888 367901 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-RNO-109606.1 Intrinsic Pathway for Apoptosis 56011 116590 64639 116554 24888 313017 171378 492821 25402 140734 29753 29748 64026 58945 100360940 246142 50689 353316 64547 116502 287606 25309 56010 64625 171528 259274 25576 25578 64044 63879 25577 690675 78963 295961 58918 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) 290027 367090 362600 84490 25591 79116 83507 29240 299112 84495 288003 361698 304573 25737 59102 288414 289758 116468 59294 89809 680915 298098 315344 362385 81528 170841 305957 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223739 Adenosine P1 receptors 29290 100911796 29316 25369 JOSEPHIN DOMAIN DUBS%REACTOME%R-RNO-5689877.1 Josephin domain DUBs 60331 292876 315134 192255 116643 64156 361381 50522 100912032 298012 56816 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-RNO-1300645.1 Acrosome Reaction and Sperm:Oocyte Membrane Binding 499152 100362588 24936 24163 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-RNO-174184.1 Cdc20:Phospho-APC C mediated degradation of Cyclin A 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 114494 100912032 360643 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 29666 54237 303353 365388 117262 85492 288671 290875 CHROMOSOME MAINTENANCE%REACTOME%R-RNO-73886.1 Chromosome Maintenance 290805 308755 364996 365877 298850 363198 362548 171121 690795 307805 287432 297483 170944 499709 681185 367645 691534 362288 287273 59102 305270 306264 684439 301965 309144 83712 290232 313048 297758 500054 307798 307861 308839 288272 689399 499873 84490 295052 65137 302783 24829 24828 288003 114494 361698 25737 301323 685909 680615 288414 289758 689296 116468 25498 59294 316602 89809 85241 303175 64627 306464 679342 306970 25448 315164 289150 361416 306945 303238 294025 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-RNO-349425.1 Autodegradation of the E3 ubiquitin ligase COP1 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 360860 287772 292766 64156 29669 29668 300711 29425 100360846 117263 25581 29666 303353 365388 117262 85492 24842 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins 266712 297337 362412 680424 308282 300837 295568 293561 500636 64460 81816 307029 50522 361831 24829 313216 29534 83477 192255 25737 363064 100912032 293184 116718 287927 363836 641452 304832 64156 116725 81920 305581 361531 312703 117044 360748 306945 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222875 TAK1-dependent IKK and NF-kappa-B activation 315599 500900 362418 308267 50522 291861 317546 81736 25493 312688 54226 309361 192255 100912032 25742 64156 116725 311245 309452 309295 310877 363520 291921 64044 313121 287707 84351 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation 304758 300837 362479 292778 303281 84389 288651 288588 500715 361580 683469 316123 303132 81785 689116 502227 114510 294693 83503 311796 298075 361365 301119 690966 362110 117017 305455 679203 291705 291703 363633 498109 289561 363064 306261 293184 304832 81807 64525 266713 361531 266787 LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance 54225 54241 294930 116563 298296 65046 266732 300438 266770 140670 83800 81782 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation 192234 299027 54318 117019 296302 64514 171145 83789 291434 81729 25347 28298 64205 26962 94266 100910714 64298 108348073 290641 361923 134480579 117042 287122 499782 308306 140661 292762 140662 29257 682390 298700 25348 300079 691947 362952 292964 81775 293418 81776 299872 81773 81768 81774 293427 100361974 288599 303831 65136 362631 691531 27139 288516 294282 360572 122799 245981 29236 681429 497860 117053 81770 100362640 64156 161477 292148 64640 100361756 29288 81764 29287 29286 81765 29285 81766 299899 124323 140654 81767 81763 171350 29304 140655 29284 300069 293484 100361060 103689992 58927 122772 117045 29258 689284 116636 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-RNO-446107.1 Type I hemidesmosome assembly 25724 691517 64315 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223943 Presynaptic function of Kainate receptors 298521 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%10223767 Sodium Calcium exchangers 140448 29715 85267 311387 24244 84550 56814 498185 314396 140447 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224161 SHC1 events in ERBB4 signaling 24525 313845 25433 24605 432361 498596 293621 64022 85385 59325 81504 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%10224453 Antagonism of Activin by Follistatin 29200 114031 24373 25196 NUCLEOTIDE METABOLISM%REACTOME%R-RNO-15869.1 Nucleotide metabolism 116593 315219 81656 289801 287368 65135 295620 312373 301005 295088 362329 25095 290029 362015 192357 79127 24165 64045 117533 290741 24465 25028 294521 313560 25368 297389 298410 102238592 292072 58964 362720 24183 24184 311833 299976 685579 29223 83782 365985 29261 619580 85260 191575 497778 64467 309390 316077 613267 314312 362638 311580 311864 288051 65156 291585 304944 24240 291824 497811 116484 311422 361068 171047 100363253 287420 361274 81643 287406 305149 288259 313574 684425 117260 315150 117544 298881 289276 140946 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-RNO-112409.1 RAF-independent MAPK1 3 activation 58960 116590 311406 50689 25622 300980 171109 361679 24498 116663 170851 60587 297682 54237 293847 24514 100361294 364052 63995 114856 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 96%10223707 EGFR Transactivation by Gastrin 24680 24525 313845 25433 24605 24329 293621 81504 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 96%10224497 Nuclear Pore Complex (NPC) Disassembly 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 25203 81738 54237 683983 53372 294429 25497 287830 499974 291874 362281 RHOQ GTPASE CYCLE%REACTOME%R-RNO-9013406.1 RHOQ GTPase cycle 24255 309175 66013 313838 64465 113960 311647 362938 303653 114116 64630 290396 299012 63994 192348 362842 116717 81679 362988 83709 29528 307459 291999 306400 114559 310074 315121 310621 292756 64678 29448 85428 29491 170824 304546 24392 117955 29431 307035 360840 314249 312108 29432 308869 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10224937 Regulation of PTEN stability and activity 287984 65138 94198 116549 29673 29671 29414 29670 29677 308051 50557 29676 29675 50522 81827 83806 311078 296988 192255 287155 100912032 24185 25233 310306 291999 287772 292766 64156 500572 29669 29668 29425 100360846 81650 291171 117263 25581 63879 79209 29666 303353 365388 117262 85492 25489 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222339 mitochondrial fatty acid beta-oxidation of saturated fatty acids 24158 25287 171155 25363 29470 170670 64304 140547 113965 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224975 COPI-independent Golgi-to-ER retrograde traffic 140734 29564 294010 294324 58945 79214 64189 252902 299850 306809 307039 363123 29489 84379 360426 289350 114113 29167 84428 81655 299121 83572 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-RNO-9855719.1 Regulation of FXIIa and plasma kallikrein activity 681544 295703 25087 300250 50692 24153 29681 306761 AZATHIOPRINE ADME%REACTOME%R-RNO-9748787.1 Azathioprine ADME 63997 494500 501110 24465 65194 363875 690050 60423 301005 494499 140944 116721 295088 83782 362329 191575 497811 24421 170924 24422 295378 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%10223915 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 64156 362418 311245 50522 308267 317546 448830 364867 363328 60350 29260 313121 192255 100912032 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity 297893 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%10225091 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 25697 304690 29175 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling 156726 689844 310405 679028 303101 301164 303539 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-RNO-9018676.1 Biosynthesis of D-series resolvins 299732 25290 29328 79242 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation 29349 25444 54250 25317 170700 289625 29369 29368 60464 170583 170582 116499 25114 66017 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 96%10223745 RHO GTPases Activate ROCKs 25537 64373 117273 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%10225109 Cristae formation 26196 171069 29754 362749 641434 690441 192241 171375 171374 65262 245958 140608 300677 171082 94271 245965 26197 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%10225387 Regulation of Homotypic Cell-Cell Adhesion 85489 680498 84430 365877 688673 116549 362850 690795 303068 25705 84407 300445 300289 293142 290270 29606 24790 78947 309757 287772 292766 64156 293721 54281 29669 29668 362040 83805 29425 100360846 83712 29382 117263 192275 25581 29666 313048 100188932 303353 365388 305679 117262 686092 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 297893 29676 500569 29675 84353 50522 310678 302783 24829 24828 81827 83806 311078 192255 117056 685909 100912032 680615 313474 292064 81679 25150 500870 303175 50654 25751 25697 311163 64627 83502 83427 306970 25507 689820 81650 266758 314641 29144 306945 81717 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-RNO-5656121.1 Translesion synthesis by POLI 89809 64156 50522 316344 313702 309812 192255 288003 25737 100912032 288414 59102 116468 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 96%10225001 AURKA Activation by TPX2 114764 117281 83836 299850 64462 311191 64158 311573 311802 311529 290626 300963 315423 83572 683722 29479 58822 363055 58945 305467 366403 367153 360672 308064 252921 293844 100362495 56010 316531 296554 310344 314787 60347 246150 29214 54237 299331 500069 29167 29213 81740 192228 307347 311546 305882 294010 25515 29753 29489 24679 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-RNO-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA 299201 361272 298942 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-RNO-9617629.1 Regulation of FOXO transcriptional activity by acetylation 84482 294515 293615 309757 301164 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%10224815 Negative regulation of MAPK pathway 299147 246781 117281 58960 305203 56011 116590 29542 311406 300980 50522 116663 24703 170851 60587 24605 297682 687346 192255 170577 293621 100912032 24525 315648 64363 65179 50689 64156 171109 361679 114486 363193 312754 309179 24673 60352 293847 63995 114856 24672 UREA CYCLE%REACTOME%R-RNO-70635.1 Urea cycle 306574 306840 29221 59085 25611 497840 29215 RRNA PROCESSING%REACTOME%R-RNO-72312.1 rRNA processing 83789 291317 291434 81729 25347 28298 313707 305258 360828 64205 26962 289809 313167 94266 310720 300092 100910714 363134 362967 64298 289810 290641 296865 192180 359727 303608 362214 360552 305076 314617 310019 315705 85432 366017 60373 361923 134480579 117042 102551819 287120 287122 291987 499782 294975 297685 64462 291061 140661 140662 29257 362902 25348 362229 300079 291996 292964 81775 293418 81776 317399 290660 81773 81768 81774 291071 100361974 314713 65136 362631 679140 691531 27139 360574 313744 58822 294282 360572 361262 122799 245981 29236 681429 497860 117053 81770 100362640 300045 64156 161477 308201 290556 64640 100361756 361159 29288 81764 29287 686999 29286 81765 29285 81766 114021 124323 140654 81767 81763 29304 140655 312706 300050 29284 690297 100361060 103689992 309301 58927 122772 29258 293828 292747 689284 288647 100360664 368084 316317 307850 29283 29282 296709 289740 64302 64306 314830 100360439 64307 50522 298065 314545 361452 134486107 362703 361977 363237 362426 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%10223035 PI-3K cascade:FGFR3 29349 84489 25444 54250 361388 25622 25317 314850 29369 29368 60464 25513 170583 116499 60662 170911 66017 81504 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%10223967 Ovarian tumor domain proteases 306886 363982 64156 50557 315911 500572 311245 24890 50522 117273 309295 100360606 361831 500133 54237 362788 362491 192255 116643 24205 293705 100912032 286761 24842 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-RNO-1663150.1 The activation of arylsulfatases 25227 311013 303631 315222 24800 365619 310326 362409 307404 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%10222233 IGF1R signaling cascade 25444 25443 54250 25622 29369 83504 29368 170583 25513 170582 25718 246273 29516 60662 170911 361992 84477 170579 25022 85243 85385 66017 81504 29349 29348 84489 313845 25233 29376 81745 361388 363131 170700 25317 314850 289625 170633 24483 65052 60464 24482 25467 79114 116499 25114 KETONE BODY METABOLISM%REACTOME%R-RNO-74182.1 Ketone body metabolism 314800 117099 24450 295458 25014 367112 65984 366463 690163 79238 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%10221937 DNA strand elongation 59294 89809 84490 85241 292058 307639 499914 290842 288003 361698 25737 301323 288414 59102 289758 116468 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME%R-RNO-9648025.1 EML4 and NUDC in mitotic spindle formation 114764 29564 117281 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 305270 83572 140734 681050 58945 684439 64515 297176 312754 114592 294429 287830 299147 292085 25515 24669 313861 297522 81738 683983 315648 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363193 363028 309179 315164 24673 304951 289150 361416 363174 81655 303037 363059 24672 AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222495 Aquaporin-mediated transport 680149 58979 114117 24400 81667 29699 24221 65054 25108 286758 64199 65133 25293 367316 25132 25386 79218 245986 25480 25241 60449 293508 81830 294962 25240 25521 25725 24679 29172 83579 29171 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-RNO-8932504.1 DAG1 core M2 glycosylations 114489 84430 688673 362567 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450513.1 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 679140 307850 56011 300944 366017 361109 79426 300045 289014 294975 CELL DIVISION%REACTOME%R-RNO-68884.1 cell division 361308 25515 315740 305343 304218 290577 313304 290668 63996 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%10224715 VxPx cargo-targeting to cilium 79120 679894 305287 64632 314961 117103 24717 60627 81830 171455 85258 24650 116654 252881 50556 29885 245709 25411 309451 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport 100188937 362495 54322 296190 362810 293448 678759 294973 291103 100912357 315167 362588 296086 362322 361894 64201 25488 685322 24551 690354 81829 301123 24401 56769 313450 84683 309111 681896 289522 304735 25309 360229 690675 303393 29445 654441 26203 25721 26202 26201 25282 26195 94194 26194 26199 288740 26198 681024 292845 26193 298748 293655 26192 81728 291671 298147 691506 293130 497902 299310 499529 686506 688386 361385 497863 681418 301011 301458 102555170 300047 296658 301416 317444 297821 360826 102550385 293453 300447 300726 362440 293991 366448 171335 303922 289218 293114 301427 64539 361520 252934 120097699 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling 64044 117279 266610 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway 64044 307366 282817 RHOH GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225179 RHOH GTPase cycle 362456 360500 303888 313050 315707 56785 83809 500929 315732 498174 81679 29528 305341 311450 25537 81522 292756 64678 29448 117955 29611 360678 29431 116643 29432 689997 308869 DARPP-32 EVENTS%REACTOME%R-RNO-180024.1 DARPP-32 events 117281 315648 140908 360616 24627 24626 25638 24668 293508 29699 363193 25521 24673 25725 24679 24672 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 96%10224535 Regulation of TP53 Activity through Methylation 64156 311613 289372 50522 305837 300711 689820 683593 304798 192255 100912032 24842 114212 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225249 RSK activation 117269 501560 81771 NGF-STIMULATED TRANSCRIPTION%REACTOME%R-RNO-9031628.1 NGF-stimulated transcription 81646 314910 114090 117535 501099 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 287984 65138 94198 361907 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 287280 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%10224659 CHD chromatin remodelers 680498 365877 690795 245957 313583 290614 25573 304832 100361269 301442 303607 83712 100362346 313048 117535 65027 290669 291794 362834 64520 84486 300837 310614 192246 361724 297093 687711 81785 297893 305479 84353 310678 302783 24829 100362099 24828 287768 681031 299620 292019 295270 117056 363064 685909 680615 291295 312974 311607 171365 303511 680737 293184 303175 307362 305501 293038 64627 308738 83726 100359714 84401 50659 300389 306970 360609 81781 291940 680891 64622 113984 406195 361531 303060 103690021 360804 306945 362093 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 56011 29753 295052 56010 25576 25578 25203 25577 313017 54237 114494 308937 307511 114212 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response 311860 368002 29722 497672 308669 293719 64557 156826 289468 116554 50522 362827 24829 362704 306257 290997 64046 290631 502935 316794 192255 85482 100912032 192218 114212 303175 287927 65179 64627 25573 313539 361815 64156 116725 301442 301128 300711 690043 292172 296099 306945 64012 24842 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%10223947 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 64625 24888 64639 64547 492821 G1 PHASE%REACTOME DATABASE ID RELEASE 96%10221949 G1 Phase 311860 117281 294790 84389 64033 114483 399489 50522 117104 81758 682033 25193 362485 24514 192255 287280 100912032 684111 100360427 315648 25164 83571 366275 64156 494444 94201 680111 266713 81515 361178 83805 499655 24673 58919 24672 24708 KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism 117099 25014 366463 690163 CELL CYCLE, MITOTIC%REACTOME%R-RNO-69278.1 Cell Cycle, Mitotic 25023 292058 307639 406168 499914 65158 290842 498266 315508 300149 303024 305392 680089 362519 362438 25573 301442 365191 498265 60336 307169 684771 308870 305343 304218 290577 313861 117103 24185 29753 25233 306464 679342 300126 287624 291441 25437 257649 307947 257644 64041 25448 94266 682908 246294 29489 307351 282834 81754 363028 291081 364419 500377 315164 307833 304951 363720 289150 361916 361416 246118 363174 84509 500363 81655 303037 313478 307511 679312 287873 300218 363059 114764 246772 29564 679886 498736 286993 114514 114087 298850 362700 83836 363198 362548 304477 29414 298594 170845 252902 85252 287101 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 24917 317252 363481 305270 83572 140734 681050 58822 58945 684439 287772 292766 64156 296368 81515 29669 29668 83805 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 24708 287984 65138 94198 294790 361907 25515 29673 116685 295052 29671 29670 29677 29676 29675 50522 116670 310806 305420 361831 366381 292588 81827 293155 292263 500929 25203 83806 311078 24514 192255 288003 114494 287280 361698 361765 25737 301323 304813 100912032 288414 360643 289758 116468 59294 89809 85241 315648 363193 301252 309179 24673 24679 316737 287447 24672 25594 117281 116590 24680 680014 692032 64158 691979 311573 309098 311802 311529 290626 300963 315423 171566 362203 683722 29479 363055 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 316531 296554 287929 310344 680991 312754 314787 60347 29214 246150 500069 299331 362980 29213 81740 192228 294429 307347 287830 311546 305882 291874 362281 24842 299147 113975 84490 299204 292085 295692 117021 64033 362335 297893 366016 58958 24669 362557 65274 302783 113929 24829 361308 24828 297522 245922 81738 25193 315740 683983 53372 25497 685909 680615 499974 303175 64627 306970 266713 689820 81650 58919 317425 306945 311860 365877 116549 84389 114483 399489 295596 299850 299112 690795 312538 117104 305171 360908 64462 316273 296178 81758 313479 682033 362485 291927 307126 360621 304573 292787 308937 59102 684111 29728 100360427 312046 298098 292071 25164 83571 301430 288532 366275 313138 313304 64528 494444 680111 94201 171102 361178 63996 362385 56010 25255 499655 307585 313048 29167 294010 85265 361643 361088 308768 306102 290668 689296 171103 316602 361613 50689 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%10223249 Adaptive Immune System 298702 25361 25464 313785 25713 116596 54266 360647 308267 81736 25493 309361 502852 498011 303024 287155 24511 56816 287927 296456 363836 308669 59326 361714 306956 302934 306957 684480 288375 497811 24185 407756 25233 29748 100361818 366962 363577 287624 24674 24675 361400 29448 29489 25578 81655 29564 29414 252902 140734 58945 81745 81515 83805 140593 50557 295338 294269 300678 313050 24981 25300 25710 24986 24932 24703 50654 25751 24968 24967 291983 29614 116689 25513 25738 366508 54259 170911 60664 85243 100913063 362046 499356 308501 298947 29433 497931 363875 361618 89821 316226 361308 297522 289168 293502 315740 85248 171041 63865 353302 314473 117550 171549 64310 314906 287276 299850 25423 685144 299121 308995 54286 81678 29337 287275 292844 24934 29167 89843 84428 58817 93646 295461 294010 301229 24232 25599 24699 310727 64019 499537 25679 25023 497932 24931 24930 246273 365542 309684 498079 294273 498287 361992 287818 353253 304349 25262 689853 364049 684529 474146 290644 684984 287531 361704 24984 361710 100361633 297596 25109 293618 689004 313644 292843 83800 292846 25424 307199 54241 361673 288244 140694 100910497 116563 680844 300649 83730 362443 312711 305081 574531 306332 89829 64465 641452 81920 311373 24812 293060 362277 361187 687633 315608 50558 192351 360534 316395 298689 317241 362294 315863 29274 305268 140939 303963 295252 316005 353227 314613 313525 305351 301674 303735 295704 363284 500017 64624 299197 498726 500262 117553 140941 308999 60383 64630 306417 289437 64631 155812 64517 362081 310363 313743 362511 498959 100360914 503446 29468 308283 499415 302987 288596 304920 308968 293023 287772 24223 65046 292766 64525 64156 287706 116743 296368 494223 685029 140670 29669 362087 29668 499114 64515 66021 171574 29425 100360846 84393 171043 619577 288921 361389 688993 117263 25581 313722 309591 367785 29666 363188 259221 305792 303353 365388 292757 360926 117262 301515 316575 85492 288671 290692 683077 290875 282845 287984 312647 65138 361219 498005 94198 360818 294790 361907 687364 29673 297930 302938 29671 685860 29670 309453 29677 690769 29676 171136 29675 500532 50522 680842 303478 305420 100909445 361831 306505 366381 94196 292588 500511 81827 362566 79129 414786 83806 306750 303689 311078 192255 296988 363790 24750 287280 24874 361765 652955 100912032 100360919 360643 311866 308901 25155 25617 295279 303336 313264 289211 297961 315648 311881 301042 362900 300950 291597 689226 81807 117537 24974 361268 316614 303792 499400 293508 300724 306825 363193 300849 117524 300968 24988 309179 313115 297592 24673 362367 316628 499877 300813 364681 25489 313445 192256 24672 367901 365527 362377 117281 362376 309758 362814 306129 24244 366854 367167 81511 81816 289508 313101 501546 314432 81815 171105 296161 500587 315707 29528 25425 312754 295347 100909827 299147 56011 25622 310678 29434 315606 302783 24829 24828 117056 64202 685909 680615 171337 303175 25697 64627 306970 304794 311567 81650 29144 290829 58919 25066 361866 306945 362093 680498 308417 365877 116549 29175 171369 690795 313806 84349 316241 83477 360640 307366 305584 289874 94201 290783 65248 362040 56010 116967 83712 290823 192275 407784 64562 313048 100188932 116643 309304 290638 686092 56718 301626 25520 83803 25639 84027 313648 362891 64226 373545 688041 363160 301555 499342 287643 64701 300955 690315 78975 360967 24605 293621 81504 24525 25150 313845 315189 116725 690516 294048 311245 296648 309295 25660 310131 29431 25408 313121 64545 362491 56822 29432 84351 84357 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-RNO-186712.1 Regulation of beta-cell development 24185 84482 25233 29414 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%10222025 Glycogen metabolism 690987 64035 81675 307091 309513 362029 24244 678739 29353 361377 140671 367562 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%10223229 Metabolism of folate and pterines 362657 64300 361472 305248 293154 299857 29723 24312 299699 64392 680308 300886 303333 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223893 IL-6-type cytokine receptor ligand interactions 310132 313173 688622 29201 81680 290655 24514 25707 100361294 245983 289747 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 96%10224631 Oxidative demethylation of DNA SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%10224257 Synthesis of PS 293620 314553 CIRCADIAN CLOCK%REACTOME%R-RNO-9909396.1 Circadian clock 287984 65138 94198 29673 29671 63840 29670 78962 29677 287422 29676 29675 50522 81827 83806 311078 192255 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225175 RHOJ GTPase cycle 299145 25513 307459 306400 310074 299012 362842 312108 310192 311647 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10223765 SLC-mediated transport of inorganic anions 691209 29501 24781 54300 308069 83629 266612 171373 246234 315311 304784 114613 29502 360670 117267 84484 301010 297910 29440 81826 25548 117955 503568 58980 295645 114629 24779 84395 297386 24780 SENSORY PERCEPTION%REACTOME DATABASE ID RELEASE 96%10222207 Sensory Perception 680149 25592 24244 81644 24400 689869 170634 64511 25318 24539 691984 171517 24710 25703 24856 25702 25680 192259 259274 116673 24771 299858 362558 300027 64047 317322 25236 296972 29216 25216 315644 25615 58920 314941 25056 55939 500091 289878 688297 85259 291318 363143 29481 140936 499132 316218 353252 116556 299521 81760 307401 363071 317498 266761 301233 293049 314264 64370 24711 25539 266714 59077 79222 89826 313689 500089 498790 100310876 307092 291283 29407 361266 171516 78981 78980 307096 364773 78983 498789 191574 78985 25649 25728 246219 292697 54225 25080 25081 78979 690448 554302 24717 24768 24767 680188 500101 286924 60449 25122 25679 302425 83579 89810 100270683 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%10222189 Dimerization of procaspase-8 306886 246756 64044 117279 266610 246097 25385 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-RNO-5624958.1 ARL13B-mediated ciliary trafficking of INPP5E 114089 363272 G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition 25594 117281 406168 692032 303024 64158 311573 309098 311802 311529 290626 300963 315423 171566 362203 683722 29479 363055 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 316531 296554 287929 310344 680991 314787 60347 246150 29214 299331 500069 362980 29213 81740 192228 307347 305882 311546 24842 117103 29753 300126 266713 246294 29489 363174 307511 114764 83836 84389 85252 299850 287101 117104 64462 311191 682033 308937 83572 58822 58945 287772 292766 64156 29669 171102 29668 56010 29425 100360846 117263 25581 29666 54237 303353 365388 29167 117262 85492 287984 65138 94198 294010 361907 25515 29673 295052 29671 29670 29677 29676 29675 50522 116670 81827 85265 25203 83806 311078 192255 114494 361643 287280 361088 361765 308768 304813 100912032 306102 689296 171103 316602 361613 315648 301252 24673 24679 24672 GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking 497913 29584 50563 84403 25751 29586 79217 50564 363677 83800 116561 24392 54241 79128 140694 116563 315840 394266 266707 25655 266706 29585 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 96%10222161 Pyrimidine salvage 304944 291824 79127 315219 362638 289801 311864 295620 291585 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 96%10225523 Degradation of CRY and PER proteins 287984 65138 94198 29673 29671 63840 29670 78962 29677 287422 29676 29675 50522 81827 83806 311078 192255 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 REGULATION OF IFNG SIGNALING%REACTOME%R-RNO-877312.1 Regulation of IFNG signaling 300772 360697 116465 25712 24514 301442 117063 89829 G2 M CHECKPOINTS%REACTOME%R-RNO-69481.1 G2 M Checkpoints 290805 308755 497672 64557 363924 303194 315969 290997 64046 290631 316794 85482 192218 114212 298534 287927 685055 310034 361815 306734 305000 300711 690043 297627 296099 360588 497856 64012 294800 24842 56011 498411 308669 291787 289468 100361529 140583 362827 24829 362704 303175 29753 64627 300126 25576 25578 25577 306945 307511 295596 287101 312538 360908 316273 296178 313479 313017 291927 307126 360621 308937 59102 29728 312046 301430 288532 287772 292766 313138 64156 29669 171102 29668 56010 29425 100360846 117263 25581 29666 54237 303353 365388 117262 85492 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 81827 25203 83806 311078 192255 288003 114494 100912032 288414 116468 116725 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 96%10223009 Chylomicron clearance 54225 300438 25728 CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress 79239 292737 315994 113894 114495 501560 116554 50658 25242 64046 297932 298103 289407 85482 362802 368044 192218 298451 299971 170667 24787 436582 297566 312488 117596 302935 94170 304569 94165 116664 366545 363849 84017 117062 25309 300711 498013 290232 297758 29702 294917 690675 24440 365057 500054 360504 307798 24468 307861 89842 64012 307480 27137 298203 114766 26195 24451 100362347 24253 26198 50551 304962 24185 303878 25352 29753 291671 25233 363138 24356 266759 85431 641452 116456 303185 25420 292721 307997 500843 293103 286899 94167 362293 84485 305464 81800 297998 81920 500907 311545 288444 297994 64317 360497 307133 29489 311427 362441 113919 366734 362573 113906 293524 298376 690751 29734 690038 360969 294744 25261 300721 259233 81655 171562 304410 304063 64371 29564 64862 29414 24404 252902 24248 85252 171361 304798 140734 58945 113898 84006 287772 292766 64525 64156 296368 29669 29668 66021 29425 100360846 361389 117263 25400 25581 24245 24246 29666 303353 365388 117262 85492 288671 303393 290875 24708 171140 192277 287984 65138 94198 83724 29673 116685 295052 29671 29445 29670 29677 83619 29676 117254 29675 50522 29338 305420 361831 366381 292588 81827 293155 79129 83806 311078 192255 114494 287280 361765 304127 24874 94194 100912032 360643 308901 681024 25617 81807 102555170 116484 301252 84478 502988 171335 100188937 362045 29560 54322 116590 24208 298576 114490 140639 84683 299027 54318 296302 360229 299331 294429 287830 291874 362281 303333 24842 363026 113975 292085 79245 293615 295692 24472 65028 117021 84578 362335 361810 366016 58958 654441 24890 310678 307151 362557 65274 302783 113929 24829 24828 297522 296732 245922 294515 25282 81738 362809 313038 260321 683983 298282 117056 25154 53372 309626 365755 25497 685909 302711 680615 499974 312947 310258 303175 303730 64627 306970 688386 315136 24186 306945 363630 25506 252934 501403 680498 54225 25081 365877 114483 299850 690795 361940 362485 59102 299121 25164 83571 309757 24413 25747 494444 94201 291145 680522 83712 201097 292887 497991 684828 295357 24437 313048 314638 26954 303016 24786 116643 117044 29167 117043 84428 56718 360776 308869 84027 310091 298514 294010 64226 688041 25672 301555 297960 78975 85265 500336 79462 24963 24426 60460 50689 316101 314322 64345 29452 54702 81771 308457 448830 117269 29260 363855 25272 24565 24516 289014 24360 116599 NADPH REGENERATION%REACTOME%R-RNO-389542.1 NADPH regeneration 50655 24479 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223391 Serotonin and melatonin biosynthesis 246281 24848 24311 317675 25120 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-RNO-6814848.1 Glycerophospholipid catabolism 360753 60418 306460 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 96%10223847 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 117269 81646 501560 81771 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222487 PKA activation in glucagon signalling 29699 25521 25725 24679 293508 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-RNO-6807505.1 RNA polymerase II transcribes snRNA genes 295448 304758 292778 298688 288588 500715 316123 689116 362813 83503 83828 298075 361365 81673 690966 83830 362110 311414 117017 309638 288533 373541 363633 294018 498109 289561 303918 117526 686980 361988 100364568 311591 24790 304204 362537 289382 171068 296102 691379 363227 305120 286917 360589 361057 690728 288514 300782 298681 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 96%10222463 Signaling by GPCR 501560 25740 362477 308118 54226 25372 24511 59075 50678 24185 308776 309962 25233 29414 25320 81745 117273 83805 25387 25388 116700 25329 24179 25605 60337 379044 25593 500157 310327 78964 25723 25513 170911 60664 85385 114559 298947 497931 317598 140928 54248 81749 688705 287730 24816 81743 24938 29254 25107 25108 25229 688605 689936 316019 29385 246075 29340 282832 116498 25340 554302 50672 25342 29141 60590 292409 58959 81678 64042 53949 308408 305795 25477 294394 246759 58965 29397 24260 58966 25111 292419 29151 24476 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25449 81753 29363 54258 84348 64373 25321 24232 81752 24473 305236 50577 289023 171551 65032 24925 24807 24806 24808 24929 81821 290493 140866 292794 100361138 117549 24247 316259 295144 316137 192223 317219 25570 81503 24241 29256 498289 63885 362505 366668 100360071 497196 100911796 497078 25542 24695 64636 302619 81648 299242 25666 117264 57305 81657 353250 60395 308163 84007 24694 25679 117027 497978 57302 89810 100270683 360579 29581 306618 499913 66013 171056 365228 500608 306307 287537 25555 29238 287418 89808 81644 689869 84009 29595 120099896 81645 310635 29237 311647 192205 310999 29235 192206 78966 170634 307398 316009 117020 24221 29234 497932 309653 84475 29471 303634 301334 171044 295449 24318 102552838 29516 360918 309207 363460 293024 294123 314386 100362710 171519 362648 24797 294124 25262 295378 685243 298404 24677 25524 310460 25645 294121 307098 246174 114098 114099 29446 363509 81672 25087 140898 361921 84023 399475 304109 310192 294807 25653 25652 687105 29491 24323 24326 81779 24448 81668 29335 301086 690158 367315 24418 24659 266997 24417 24419 24772 114105 24414 60628 24416 25504 24415 445269 309212 25187 64465 83633 500091 171371 494319 497942 56813 117064 64680 498475 192648 363143 192649 29481 246358 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 56820 310444 25075 25195 29555 192646 501177 500089 100310876 301066 25726 113914 679957 287910 298006 116506 24875 29407 25040 78981 78980 171158 78983 362454 78985 498335 117041 25616 366270 24769 366274 29538 117029 245920 83518 24889 246219 266607 60669 406163 25051 29480 60665 54289 29413 54294 29412 54293 78976 54292 25298 54297 679975 54296 54305 498246 85268 301088 78979 302378 84583 25706 100361166 365901 25026 59293 170926 84022 259224 114705 259222 25029 246254 24613 362021 25380 289076 25264 24174 690448 25024 60432 25265 361383 363682 29180 288995 378939 498791 691774 116677 29636 319107 64803 319105 24182 25033 29191 24180 287673 499194 113959 24717 25245 63843 25248 170704 117518 24953 25007 260319 680188 25360 58812 287561 287562 24604 63850 502757 171104 171108 500101 83567 24166 310869 29290 171101 58949 64199 24654 286924 83506 24611 315648 79218 360616 24627 24626 25638 81636 245986 25238 24668 60449 25031 293508 302950 85240 363193 294962 64532 25521 25686 24673 25289 25643 25601 25725 24679 83579 29241 24672 367901 680149 84420 117281 58979 116590 140908 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 81662 81664 60341 29691 25433 29316 25369 25083 24175 24329 29597 114513 294075 59301 25537 81663 66025 306792 298062 60399 310812 116744 29415 29733 500317 24605 293621 81504 24525 81646 313845 50689 81771 117269 29431 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10224939 COPI-mediated anterograde transport 297428 29564 300888 79120 304290 54400 363136 252902 192243 299850 310411 56042 140940 60384 290659 64351 65165 300674 291990 299121 140734 140673 503165 246310 58945 690961 24506 24505 64528 171049 84599 114023 29631 25407 304978 94189 29167 84428 79117 361207 252889 314030 294010 361577 289257 305614 64159 314251 308458 29489 81754 64154 293456 64310 362162 361073 81655 309451 60355 65134 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%10222611 Regulation of clotting cascade 171154 306608 24617 24946 25592 502858 315272 29436 29243 29366 54226 295703 360918 499099 25268 308637 260320 362248 116727 25087 83580 691984 171517 691992 65051 314615 25259 306761 302470 116673 24771 79224 304917 317322 25236 25216 25615 58920 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-RNO-9027284.1 Erythropoietin activates RAS 29376 287942 24514 24335 81515 85385 81504 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%10224851 DNA Damage Recognition in GG-NER 290027 25591 117039 363273 315523 65137 363283 50522 100362121 291737 192255 302502 361381 100912032 361181 298012 296084 361925 287367 85423 360915 293494 64156 287876 261736 24919 316440 362258 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 96%10222417 Formation of Incision Complex in GG-NER 290027 25591 83614 84389 288651 361580 304719 502227 294693 50522 100362121 313098 291703 192255 302502 361381 100912032 59102 361181 298012 310707 287927 690244 25573 64156 116725 301442 266713 499417 300772 300813 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222847 MAP kinase activation 315994 117281 116590 315305 114495 501560 116596 116554 362418 300980 308267 50522 50658 317546 81736 116663 309361 60587 303024 192255 287280 361765 100912032 315648 81646 50689 81647 64156 116725 314322 311245 309295 81771 117269 363193 500133 363520 24673 313121 362491 363855 25272 84351 24516 289014 24672 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%10224567 Regulation of necroptotic cell death 26295 50522 60371 192255 287155 266610 246097 100912032 25385 690743 56816 501083 306886 64665 246756 246240 363836 117279 114562 83764 64156 83841 311567 64044 63879 299331 305549 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding 170582 25114 289625 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism 680149 266607 25051 58979 114117 24400 81666 81667 29699 24680 81662 81664 24778 289036 312670 24239 246253 171078 25262 25736 246153 83588 307234 81678 83688 64524 25083 24953 64562 24175 295347 83535 373545 25559 78975 59326 64199 24654 79218 245986 60449 293508 85240 294962 64532 25297 25398 25521 25686 116600 25289 113976 300992 25679 25725 24679 83579 114024 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 96%10224521 SUMOylation of transcription cofactors 287662 310258 310375 83422 303730 83614 290744 690244 25573 304157 301442 499417 307151 362827 300772 29382 117287 313128 313038 315133 309626 116698 25498 501403 ACTIVATION OF TRKA RECEPTORS%REACTOME%R-RNO-187015.1 Activation of TRKA receptors 59109 310738 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224313 Synthesis of PIPs at the Golgi membrane 114089 305419 361632 363131 114554 307842 309855 316457 116482 65052 140940 64310 81747 364629 116720 CD28 CO-STIMULATION%REACTOME%R-RNO-389356.1 CD28 co-stimulation 299147 117281 64226 64465 116596 29414 313050 25513 497932 246273 366508 360640 170911 361992 60664 85243 81504 24185 25150 315648 25233 81745 366962 298947 315189 29433 497931 81515 363875 296648 83805 25660 363193 312754 310131 29431 309179 25408 24673 56822 29432 56718 24672 CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport 25552 295245 24778 85256 294341 303205 25139 64522 25551 304785 501925 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 96%10224065 Reactions specific to the complex N-glycan synthesis pathway 308757 432392 140568 25478 24375 94273 PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis 24689 29562 314140 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223763 Bicarbonate transporters 24781 117955 266612 295645 84484 315311 24779 297386 24780 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224171 ATP sensitive Potassium channels 83535 25560 25559 25472 COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis 362495 296190 678759 294973 100912357 315167 362588 296086 361894 25488 690354 26203 301123 26202 56769 26201 313450 26194 26199 26193 298748 293655 81728 291671 298147 293130 299310 499529 361385 497863 681418 301458 296658 297821 360826 293453 300447 293991 362440 303922 289218 293114 301427 64539 361520 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism 361730 684314 24188 25659 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-RNO-399997.1 Acetylcholine regulates insulin secretion 24680 85240 81662 81666 24654 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 96%10222853 Signaling by Interleukins 315599 315994 500900 113894 309157 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 25466 301059 116663 117022 54226 24493 309361 300177 60587 361677 303024 303604 314870 60582 25402 85491 25216 89829 500985 682457 498951 25613 81802 688621 29197 84492 25578 116470 24803 680609 290655 84405 171334 171333 689932 365368 155140 317553 287772 292766 64156 81515 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 361749 29677 29676 29675 50522 313050 81827 24932 83806 311078 24514 192255 287280 361765 100912032 25155 25734 315648 290257 24498 363193 25467 24673 299827 24672 117281 116590 25704 171081 65038 116689 25513 25326 25746 362077 116562 366508 171106 116630 54259 170911 60664 84477 85243 54245 85385 25012 311783 29376 296541 84388 499744 373540 301365 25622 24918 25126 365769 690369 310678 116558 25670 50646 287942 100361294 29144 25506 680498 100911249 25325 362629 362628 500836 310132 313173 688622 29201 81680 681112 444986 685840 25707 245983 304091 289747 170819 81803 81804 81504 25084 25150 81646 287287 362862 313845 116553 25125 50689 500616 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 25556 363520 291921 64044 313121 362491 287707 363855 25272 84351 24516 289014 305549 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport 297428 29564 300888 294324 79120 304290 296750 252902 299850 84379 140940 60384 289350 290659 65165 300674 299121 83572 140734 140673 503165 246310 58945 79214 84599 114023 84393 304978 29167 84428 79117 361207 252889 294010 361577 140932 300158 64189 316226 307039 363123 361308 363288 289168 171291 113886 293502 114113 315740 85248 171041 360953 313254 353302 287624 294286 246209 303575 306809 303659 29489 314473 81754 289309 360426 117548 117550 171549 64310 362162 314906 81655 309523 289397 309451 60355 363059 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases 29560 360471 24208 363084 298576 56084 315911 360763 315639 309153 25493 312688 306886 298534 24842 29240 64646 24828 25700 502125 680615 363445 306970 365877 85471 60371 304798 303539 287772 292766 64156 29669 171102 29668 79257 64515 29425 100360846 117263 25581 29666 303353 365388 117262 302415 85492 290864 288306 24255 287984 29134 361190 65138 100361658 94198 684097 294790 140593 29673 25387 25388 295052 313427 29671 29591 50554 29670 361749 29677 308051 50557 29676 362414 65137 29675 25631 50522 688466 310960 308896 100362121 171152 81827 83529 360990 83532 83531 293345 83806 302488 311078 266601 192255 290652 114494 408217 363164 100912032 114558 115771 361495 304150 310306 307905 24577 296121 683630 311245 499801 309295 362636 81516 314453 297593 84478 25671 171329 312937 313121 29357 311856 304017 293705 288482 304579 311030 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224645 Hedgehog ligand biogenesis 287984 362891 65138 94198 29673 303743 29671 29670 29677 29676 311324 29675 499241 50522 361712 81827 83806 311078 192255 100912032 84399 84380 287772 292766 289874 64156 29669 29499 29668 29425 100360846 117263 25581 29666 303353 116643 365388 117262 85492 25506 DEPYRIMIDINATION%REACTOME%R-RNO-73928.1 Depyrimidination 367090 680915 315344 81528 305957 GENE SILENCING BY RNA%REACTOME%R-RNO-211000.1 Gene Silencing by RNA 680498 365877 292778 308971 288588 690795 310678 303774 83503 361365 302783 690966 24829 64028 24828 117017 363633 498109 289561 117056 685909 680615 303175 192178 64627 306970 686774 311130 306945 298533 84509 299284 363006 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine 367090 680915 315344 81528 305957 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 96%10224479 Ca2+ pathway 680149 64512 58979 317674 24244 114117 24400 289878 688297 84353 365901 81667 282581 307401 64199 24525 266715 29748 79218 497961 140584 100361818 50664 24674 245986 161452 24675 64558 60449 294962 25400 313121 83579 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis 301221 64845 361300 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222039 Aerobic respiration and respiratory electron transport 100188937 362495 296190 54322 362810 293448 678759 294973 291103 100912357 315167 362588 296086 362322 361894 64201 685322 25488 690354 24551 81829 301123 24401 56769 84683 24651 25104 309111 361596 681896 296849 311254 25309 360229 690675 293615 289950 654441 298942 26203 288731 81654 26202 26201 81530 89813 25282 117098 26195 26194 26199 26198 26193 26192 291671 688386 364686 360826 293991 245958 140608 300677 171082 94271 245965 252934 26197 26196 171069 29754 362749 641434 690441 192241 171375 171374 65262 313450 24439 294320 24533 24534 298982 83536 307270 315949 361602 497900 302980 290705 290985 369018 79250 362474 114597 301624 64156 287069 298596 289522 362323 157074 304735 498226 170587 310378 24368 85263 25708 499125 54315 363061 24860 289217 114096 361726 94173 81670 303393 299201 360975 29445 50522 25721 83529 681913 192255 85333 94194 100912032 681024 288740 292845 298748 293655 81728 298147 691506 293130 497902 299310 499529 25014 686506 361385 497863 681418 301011 301458 102555170 300047 296658 301416 317444 297821 102550385 293453 300447 300726 362440 246311 366448 54705 171335 303922 289218 293114 301427 64539 361520 120097699 CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling 25150 140908 25416 116671 65208 312213 246331 25418 309280 25415 25417 361597 29751 289392 84027 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-RNO-2871796.1 FCERI mediated MAPK activation 116667 116590 81511 116554 50658 25738 24605 293621 100360919 85385 295378 25155 81504 24525 313845 366962 50689 314322 81515 363875 29337 29431 363855 29432 25272 24516 NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation 79239 24434 363247 81736 361677 116690 296456 299314 24856 296654 24440 29662 25019 307039 287427 287709 94197 24691 29543 50645 499285 246324 29448 29153 29489 683849 307833 25406 50866 103690254 288779 25531 362347 63849 29650 25052 252902 367915 171361 361697 84379 25095 290029 58945 292072 361929 117273 306600 83782 311396 117284 363024 294329 81679 50654 117152 252929 302526 290257 282817 24590 301252 246280 100360623 294673 292073 299825 116689 309147 25012 288305 83841 363875 84497 296554 299732 314787 29214 299331 81687 25290 299809 306998 361537 140868 81613 24159 140914 24944 54249 315272 24648 29364 29511 25423 308875 299121 308995 29385 29583 291085 690945 292409 114023 29221 25407 25505 25518 679787 78963 140656 24614 56611 29186 362638 54258 24479 24232 94195 81503 293130 25103 314615 25441 24699 84007 25528 24795 84491 81683 301005 362329 309684 29757 499099 29192 25524 170667 25373 292843 289231 292846 292485 100362805 690158 83730 293118 300250 574531 24468 306332 367562 64035 81675 362029 25307 432363 246358 94167 58857 64537 24248 64630 289820 501072 65192 361383 24917 24375 315348 287772 24223 29669 113959 66021 306871 25581 303353 365388 100361814 85492 688730 29143 304284 363127 287984 312647 56780 360854 259275 94198 500361 445415 499157 58970 690906 58949 317335 306324 29677 290923 100125364 64185 303180 680842 308632 497195 291091 81641 29205 114091 474169 360914 79129 306760 414786 83806 65197 287721 311078 54243 498128 498234 64681 24750 84397 690130 79113 84398 299606 304692 291854 290409 304543 192177 289211 85274 25739 302495 291755 140665 360618 500324 298792 684322 298682 24974 266775 304988 288778 58826 499400 303542 192264 291948 24257 24251 292537 24988 304966 29714 83462 362966 361635 291339 293753 292666 25328 84586 288174 295706 365527 362045 499271 304822 25455 302890 116590 450222 360445 25308 170538 289318 361422 291759 64527 501546 314843 100364984 690263 308666 298066 315916 89824 79130 362432 362431 361467 363522 313837 300857 29142 25046 29521 361378 59313 378947 170923 246272 25741 83799 83781 362249 246250 311821 363463 113940 292804 29738 25060 25374 310864 24189 309649 25035 366988 25551 25151 25425 293154 81506 24191 305679 295347 24642 362859 83578 315085 24472 29565 363494 171337 25227 315222 361171 296321 116547 310553 84431 81650 100361909 316519 84387 498840 498659 498658 301034 316010 314618 305234 286995 613220 613223 613224 286958 613225 156767 170496 360509 291000 290856 362893 316033 315949 25096 50692 116967 116643 308869 313648 289032 64189 63880 24605 64159 24426 171341 29292 364867 79209 60350 25319 24206 24464 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-RNO-5685939.1 HDR through MMEJ (alt-NHEJ) 290027 84495 84490 288079 25591 64046 297561 291787 85482 64012 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%10223573 Tachykinin receptors bind tachykinins 25007 24807 24806 24808 29191 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 96%10222361 Transport of Mature mRNAs Derived from Intronless Transcripts 113975 292085 295692 117021 362335 366016 689116 58958 362557 298075 65274 113929 297522 245922 81738 683983 53372 25497 499974 299256 304277 289582 681062 59087 690585 294429 117045 287830 291874 362281 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 96%10223599 Adipogenesis 25664 84578 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-RNO-77595.1 Processing of Intronless Pre-mRNAs 365407 314417 299811 116697 304277 289582 683927 689116 298075 291877 311670 311166 299256 VITAMINS%REACTOME DATABASE ID RELEASE 96%10223395 Vitamins 308190 312495 25279 114700 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-RNO-192105.1 Synthesis of bile acids and bile salts 301517 83569 83724 362782 309527 192242 65192 25541 498790 307092 291283 361266 79244 171516 307096 364773 498789 25429 191574 362360 298369 259221 29725 25428 296461 79111 311129 246211 60351 303497 MELANIN BIOSYNTHESIS%REACTOME%R-RNO-5662702.1 Melanin biosynthesis 100365773 308800 290484 310152 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225141 Interleukin-9 signaling 25326 25125 24918 25126 116558 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs 81639 25290 287454 29527 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere 59294 89809 364996 85241 290232 297758 288003 500054 361698 307798 25737 307861 301323 288414 303238 289758 116468 294025 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225347 RND3 GTPase cycle 287543 300838 310090 29745 310999 362938 361029 25513 299012 293497 24264 315829 192207 291755 306400 304893 310074 25306 83764 301007 89816 295588 312667 366492 289229 306871 305645 140922 302855 498331 362859 305605 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%10223923 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 679140 24185 307850 56011 300944 366017 361109 29344 300045 289014 294975 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%10222543 Regulated Necrosis 679886 26295 50522 60371 24493 192255 287155 266610 246097 100912032 25385 299606 690743 29197 56816 25402 501083 306886 64665 246756 246240 363836 117279 114562 83764 64156 353316 83841 116502 25309 311567 171528 282834 365191 364419 64044 63879 363720 299331 690675 361916 287873 305549 PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-RNO-169893.1 Prolonged ERK activation events 58960 56011 116590 50689 314850 114486 59109 310738 170851 287942 295347 116478 54245 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006927.1 Signaling by Non-Receptor Tyrosine Kinases 29560 498596 117268 170843 64015 50522 24697 362271 25414 296472 24605 192255 293621 29496 100912032 54245 59325 24525 24185 83571 306400 25433 25125 25313 25676 366275 64156 94201 64022 312477 363875 300160 117273 361617 432361 58919 24329 360820 89829 500985 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855196.1 IP3 and IP4 transport between cytosol and nucleus 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 294429 25497 287830 499974 291874 362281 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 96%10223265 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 365527 298702 308417 25361 25464 313785 25713 54266 171369 360647 84349 24931 24930 309684 498079 498287 287818 24511 353253 304349 689853 364049 308995 474146 308501 684984 24223 100361633 25109 293618 689004 292843 292846 307199 361673 288244 100910497 292844 680844 24934 300649 362443 312711 305081 89843 574531 300678 680842 301229 24232 25300 25710 414786 24750 100360919 289211 24974 499400 24988 25066 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224415 NOTCH3 Activation and Transmission of Signal to the Nucleus 500538 56761 291999 25313 81751 29650 64156 29146 50522 311332 289231 84010 24329 300802 192255 29192 100912032 292788 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-RNO-9615017.1 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 60331 302415 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 96%10223845 Zinc influx into cells by the SLC39 gene family 361986 300051 295455 294281 291733 305846 306009 314637 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism 24782 50568 316583 25181 305571 300993 84400 362275 404783 84468 29139 367166 293667 24434 25592 367145 363513 25393 307859 294673 314771 114122 292073 64507 313536 500961 494342 299825 81682 58968 65196 291577 291770 297554 500257 304322 302302 314694 316533 691984 171517 64152 282821 25694 116673 24771 304885 315939 298690 266805 317322 25236 25216 25615 58920 303218 294449 302489 293451 292155 295430 84406 29633 363618 114002 364476 684979 108349781 299907 360670 117267 294103 295443 306866 25227 25697 25406 688293 64537 360630 368128 363103 363040 64442 64445 316033 362924 246232 290638 500052 116721 295934 81651 300757 286974 301525 361450 365583 291015 297865 303923 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 360471 117039 292778 84389 288651 288588 361580 366163 304719 502227 245976 299112 294693 83503 361365 690966 117017 291703 363633 498109 289561 171525 304573 302502 59102 361181 298098 360915 64156 362385 314061 306274 362479 363273 497967 50522 363283 84495 192255 288003 361698 25737 100912032 288414 289758 116468 59294 89809 287367 246216 266713 362394 261736 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%10223367 Transport to the Golgi and subsequent modification 362275 313536 494342 65196 140808 303100 65271 362625 295319 29582 299756 81519 367252 315059 362599 297522 287427 29183 367073 29489 81754 64154 680465 289994 293456 64310 362162 361073 81655 54350 287276 309451 309678 60355 65134 297428 290994 29564 300888 246117 79120 304290 54400 58842 363136 690252 299075 171121 252902 192243 299850 292074 310411 25547 24648 300743 64462 100912115 56042 117523 252853 89868 140940 60384 501550 290659 64351 65165 291325 300674 291990 363040 25423 685144 24375 299121 362237 94273 308757 306264 140734 309010 432392 25478 140673 503165 246310 58945 690961 25197 361705 301012 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 304978 116666 117513 100360302 94189 29167 84428 79117 361207 50592 252889 58817 93646 314030 295461 294010 361577 289257 305614 64159 314251 308458 252929 140568 24827 303923 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%10223821 Transport of glycerol from adipocytes to the liver by Aquaporins 65054 29171 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%10222573 GPVI-mediated activation cascade 64465 25622 81511 54320 64373 313050 116689 25513 497932 500336 684555 170911 60664 85243 295378 25155 308875 25150 81745 298947 497931 81515 363875 25441 117273 29337 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%R-RNO-1234158.1 Regulation of gene expression by Hypoxia-inducible Factor 29560 25242 64345 29452 114490 CIPROFLOXACIN ADME%REACTOME%R-RNO-9793528.1 Ciprofloxacin ADME 170698 24904 312382 24186 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%10224439 Electron transport from NADPH to Ferredoxin 313786 29189 79122 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224319 SRP-dependent cotranslational protein targeting to membrane 361923 134480579 117042 287122 499782 140661 140662 29257 25348 300079 292964 81775 293418 81776 81773 81768 81774 100361974 362631 65136 691531 27139 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 81767 140654 81763 29304 140655 29284 100361060 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 291685 134486107 83789 690345 291434 81729 25347 28298 64205 26962 94266 116650 100910714 64298 290641 PI METABOLISM%REACTOME%R-RNO-1483255.1 PI Metabolism 360753 300147 60418 84018 500132 25532 65038 171088 25513 497932 140940 85238 366508 54259 170911 60664 81747 364629 85243 116720 298947 497931 116482 498331 307428 287533 64633 295674 114089 301131 305935 246237 282584 308584 309419 367786 289021 50557 360521 310663 114561 306490 361659 305482 364298 312634 94197 305419 288762 361632 363131 114554 307842 116699 309855 116723 316457 80849 89812 65052 310155 314641 64310 317296 365865 306460 140607 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%10222693 Porphyrin metabolism 79239 292737 494500 25374 58978 140860 24186 25748 65155 289219 691853 309391 309070 304024 361338 24861 312382 25303 24565 24451 24360 116599 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%10222785 Toll Like Receptor 4 (TLR4) Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 60371 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 266610 306886 246240 680127 64156 171574 29337 140694 25622 50522 361831 291359 246116 192255 287280 361765 100912032 315648 81646 25751 641452 50689 25742 81647 296321 116725 314322 311245 309452 81920 309295 81771 293624 310877 287545 117269 246294 448830 500133 364867 363193 363520 252961 363328 291921 60350 64044 29260 300447 313121 24673 362788 362491 299827 292892 287707 363855 25272 84351 24516 289014 305549 24672 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%10223569 Clearance of dopamine 308868 24898 24267 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223091 Intestinal absorption 25552 65197 432367 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%10223081 Digestion of dietary carbohydrate 497039 289032 113901 KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 96%10224743 KEAP1-NFE2L2 pathway 113894 64862 29414 298576 140639 84006 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 116643 365388 117262 85492 84027 287984 65138 94198 29673 301555 29671 29670 29677 83619 29676 78975 117254 29675 50522 81827 83806 311078 192255 287280 304127 361765 100912032 308901 24185 303878 25233 84478 502988 NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly 499873 298850 365877 363198 362548 65137 690795 307805 302783 24829 24828 681185 685909 680615 305270 689296 25498 316602 303175 64627 684439 306464 679342 306970 25448 83712 315164 313048 289150 361416 306945 308839 288272 689399 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis 84114 84470 287380 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-RNO-380320.1 Recruitment of NuMA to mitotic centrosomes 114764 117281 83836 299850 64462 311191 692032 64158 311573 309098 311802 311529 290626 300963 315423 83572 171566 362203 683722 29479 58822 363055 58945 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 56010 316531 296554 287929 310344 680991 314787 60347 246150 29214 54237 299331 500069 362980 29167 29213 81740 192228 307347 305882 294010 25515 308870 29753 29489 24679 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223911 activated TAK1 mediates p38 MAPK activation 315994 114495 116725 362418 311245 308267 309295 317546 500133 363520 313121 362491 289014 PHOSPHORYLATION OF THE APC C%REACTOME%R-RNO-176412.1 Phosphorylation of the APC C 25515 296368 305420 361831 366381 292588 361389 293155 25203 54237 360643 288671 290875 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223363 COPII-mediated vesicle transport 290994 246117 58842 690252 299075 171121 292074 24648 300743 64462 56042 252853 89868 501550 64351 65165 25423 685144 362237 306264 309010 140673 361705 301012 64528 171049 309144 84599 29631 302470 287275 25407 116666 117513 100360302 50592 58817 93646 295461 315059 362599 297522 287427 29183 252929 367073 81754 64154 680465 289994 24827 54350 287276 309678 60355 65134 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 117553 81827 309361 83806 311078 360640 303024 192255 287280 361765 100912032 287772 292766 64156 29669 29668 309452 29425 100360846 117263 25581 29666 303353 365388 117262 85492 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%10225059 MET promotes cell motility 25614 171337 360606 361388 170921 691517 363875 83805 24553 313388 287942 303517 295347 24511 54245 309816 24446 81504 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 96%10222371 C6 deamination of adenosine 81635 25367 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224951 Intra-Golgi and retrograde Golgi-to-ER traffic 294324 296750 500906 296649 500249 362283 100361513 29528 192152 309798 65277 64187 286932 79214 293344 685079 25218 120097389 312689 25151 60562 364981 309922 117051 311919 365793 300158 316226 64516 307039 363123 361308 363288 289168 171291 113886 293502 315740 85248 171041 313254 353302 287624 294286 246209 313493 303575 303659 29489 314473 81754 289309 117548 315668 64154 117550 171549 293456 64310 84589 362162 314906 361073 81655 309523 289397 309451 60355 65134 363059 297428 29564 300888 79120 304290 54400 252902 299850 310411 367915 84379 140940 60384 290659 289350 64351 65165 300674 291990 299121 83572 140734 140673 503165 246310 58945 690961 84599 114023 84393 304978 94189 29167 84428 79117 361207 252889 314030 294010 361577 140932 64189 367308 114113 360953 116692 116691 100359675 306809 360426 64621 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%10225023 PTK6 promotes HIF1A stabilization 29560 25433 24329 366275 300160 FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation 81613 24511 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-RNO-8874177.1 ATF6B (ATF6-beta) activates chaperones 89842 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%10222703 Conjugation of carboxylic acids 293779 353317 246263 688536 361637 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 96%10225551 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 294754 361923 134480579 117042 287122 499782 140661 140662 29257 25348 300079 292964 81775 293418 81776 81773 81768 81774 100361974 362631 65136 691531 27139 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 81767 140654 81763 29304 140655 29284 293408 100361060 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 83789 291434 81729 25347 28298 64205 26962 94266 100910714 64298 290641 LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism 171151 100169747 117024 299201 29416 291450 296925 303272 361272 364975 298942 300723 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10224399 Synthesis of 15-eicosatetraenoic acid derivatives 81639 266604 24404 29527 29328 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%10222761 Transcription from mitochondrial promoters 85261 289307 83474 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%10222579 Effects of PIP2 hydrolysis 499913 29340 170538 54248 81678 81749 305795 688705 25666 60395 309207 81821 25679 29254 497978 140866 100361138 25262 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-RNO-9668328.1 Sealing of the nuclear envelope (NE) by ESCRT-III 246772 679886 498736 362700 316531 296554 307351 282834 291081 365191 364419 500929 500377 307833 363720 64158 361916 246118 29213 500363 313478 679312 287873 300218 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 96%10223059 EGFR downregulation 361120 64465 117277 56084 50522 306141 192255 294981 100912032 81504 313474 59325 29183 117255 81922 25433 25313 114559 64156 116743 64022 498798 81921 24329 24827 311030 500985 84357 N-GLYCAN ANTENNAE ELONGATION%REACTOME%R-RNO-975577.1 N-Glycan antennae elongation 362275 367252 25197 313536 25547 494342 117523 65196 303100 291325 65271 363040 299756 303923 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%10221953 TP53 Regulates Transcription of Cell Cycle Genes 58936 301513 83571 295052 295707 287249 316034 363603 83722 363221 25203 313017 362485 29619 54237 306492 114494 291841 25737 307511 312227 314818 25498 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 96%10224393 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 81810 29591 64156 690516 50522 117273 192255 310655 116479 100912032 81918 59086 25522 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs 58960 315994 117281 116590 314910 315305 114090 501560 300078 501099 314612 300980 25513 59109 116663 310738 25738 60587 170911 85243 116478 54245 85385 29376 65046 314850 116743 54281 140670 363875 117273 83805 83800 54241 116563 117535 295347 56011 170851 24605 287942 293621 29613 81737 29622 81504 24525 25150 315648 81646 313845 315992 50689 25507 116548 81771 114486 117269 363193 24225 25467 24673 25730 25054 289014 24672 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%10225075 MET activates STAT3 24553 25125 24446 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10224537 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 25573 313596 291772 301442 BETA DEFENSINS%REACTOME%R-RNO-1461957.1 Beta defensins 641658 641627 310553 641632 305354 641636 641651 641650 83687 641624 641644 308163 641652 641655 641657 641656 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225035 Regulation of RUNX1 Expression and Activity 25193 64033 58919 114483 25622 50662 361391 TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 96%10222787 Toll-like Receptor Cascades 116667 315599 117281 315994 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 24366 54226 309361 24367 60587 303024 266610 306886 246240 680127 140694 25622 291359 246116 501570 305355 63865 684440 25697 361689 312562 641452 295214 296321 116547 353316 317468 310553 305354 81920 246294 54225 29175 60371 64156 171574 29337 50522 361831 94195 192255 287280 361765 100912032 315648 81646 50654 25751 362862 50689 25742 363131 81647 116725 314322 311245 309452 309295 293624 81771 310877 287545 65052 448830 117269 500133 364867 363193 363520 252961 363328 291921 60350 64044 29260 300447 313121 24673 362788 362491 299827 292892 287707 363855 25272 84351 24516 246280 289014 305549 24672 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%10222813 Initial triggering of complement 24233 406161 64459 298566 24232 29687 114091 362634 25419 64023 64668 312705 100360919 192262 299928 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%10224249 Synthesis of PE 89841 360843 29194 316737 310773 29367 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224307 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 117281 116590 25444 25443 54250 29369 29368 25513 497932 170583 25466 301059 170582 300177 366508 29496 170911 60664 170579 84477 85243 66017 29349 29348 84489 25433 29376 25313 361388 298947 25317 497931 314850 363875 170633 29149 24553 312754 79114 24329 24446 299147 25622 498596 24890 83504 25149 60427 60662 29613 81737 25267 25022 25266 59325 29183 24185 24629 24628 170700 64022 289625 60464 314641 308875 24506 24505 83805 309419 361749 313050 81504 25150 315648 50689 311245 294048 116723 25660 89812 294235 25556 363193 363520 24225 25467 309179 116499 25408 432361 24673 64545 64030 24827 56822 25114 25730 25054 365865 140607 24672 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224045 Negative regulation of FGFR4 signaling 117281 116590 25444 54250 25622 29369 50522 29368 500526 306141 170583 170582 192255 100912032 66017 81504 29349 50689 170700 25317 64156 314850 289625 83805 114486 60464 116499 24673 25114 500985 24672 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%10223761 Synthesis, secretion, and deacylation of Ghrelin 25204 24391 59301 24482 266758 24506 24505 301265 25608 293142 306515 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME DATABASE ID RELEASE 96%10223199 Axonal growth inhibition (RHOA activation) 83765 317598 450224 24596 360678 29409 117273 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 96%10224179 Classical Kir channels 116649 29712 276720 VEGFA-VEGFR2 PATHWAY%REACTOME%R-RNO-4420097.1 VEGFA-VEGFR2 Pathway 315994 25023 24244 170538 29414 314612 83785 308666 362271 682937 25589 24680 25513 25738 246273 170911 679934 361992 85243 54245 295378 29302 296456 316369 81745 25676 315348 25537 29433 363875 117273 83805 66021 362513 310688 299331 313024 56718 117542 64226 64465 300955 84353 50646 25414 58823 79129 24605 293621 25522 25614 24185 81679 24525 25150 25233 311163 24600 315189 170897 296648 293508 310131 29431 286928 60352 79249 29432 360820 294568 289014 METALLOPROTEASE DUBS%REACTOME%R-RNO-5689901.1 Metalloprotease DUBs 365877 497672 64557 289468 301164 64156 306970 498798 50522 64646 362704 24828 290997 502125 171565 290631 287362 316794 311078 192255 100912032 680615 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10225535 Interaction of NuRD complexes with transcription factors 680498 365877 310614 361724 297893 690795 310678 302783 24829 24828 117056 685909 680615 303511 303175 307362 305501 293038 64627 100359714 50659 306970 291940 113984 406195 83712 360804 100362346 313048 117535 306945 290669 362834 64520 GAB1 SIGNALOSOME%REACTOME%R-RNO-180292.1 GAB1 signalosome 29183 25433 25313 361388 25622 64022 83805 315707 64019 25513 24329 170911 24827 360820 81504 59325 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%10222733 Post-translational modification: synthesis of GPI-anchored proteins 100910143 81613 362133 287159 117522 364032 541462 378774 362934 315807 116658 288041 59318 366478 690037 50864 192263 362756 312806 691120 29142 59313 363104 50692 295543 316400 303277 353304 293154 288038 300027 81506 367308 60333 25586 114589 311169 83834 415062 353251 54279 691259 309659 307992 363060 207113 100359675 681194 313488 117054 24257 314180 300017 300653 64621 304966 315075 360838 291132 24832 113910 681033 296394 292666 29561 502017 29640 116597 79112 60378 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10222065 Neurotransmitter release cycle 116470 25531 24803 60422 29647 24379 81632 29642 497009 24949 24380 83589 79130 85426 29179 60442 29130 29483 29482 24904 366432 29503 25716 64830 50676 293645 116638 64832 79212 60377 66028 25550 25558 25549 83612 140592 24398 79213 84556 25012 171163 192268 84012 24468 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%10224009 Calnexin calreticulin cycle 29468 29144 192255 64156 64202 50522 100912032 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%10223405 Platelet sensitization by LDL 299147 54225 117281 315648 29583 25622 116689 363193 312754 309179 362558 24673 79113 24672 TRIGLYCERIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10223079 Triglyceride catabolism 25598 64822 79131 25062 80841 25440 140868 24360 499570 300108 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855229.1 IP6 and IP7 transport between cytosol and nucleus 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 294429 25497 287830 499974 291874 362281 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%10223039 Signaling by FGFR3 117281 116590 25444 54250 25622 29369 50522 29368 500526 306141 170583 25513 25738 24605 192255 60662 293621 170911 100912032 85385 366061 66017 81504 29349 24525 84489 313845 361388 50689 25317 64156 314850 83805 114486 60464 116499 24673 500985 24672 316213 REELIN SIGNALLING PATHWAY%REACTOME%R-RNO-8866376.1 Reelin signalling pathway 25150 24718 266729 84357 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-RNO-159231.1 Transport of Mature mRNA Derived from an Intronless Transcript 113975 292085 295692 117021 362335 366016 689116 58958 362557 298075 65274 113929 297522 245922 81738 683983 53372 25497 499974 299256 304277 289582 59087 690585 294429 117045 287830 291874 362281 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling 64226 116596 29414 313050 25513 497932 246273 366508 360640 170911 361992 60664 85243 24185 25150 25233 81745 298947 315189 497931 296648 25660 310131 25408 56822 56718 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 96%10222937 Downregulation of SMAD2 3:SMAD4 transcriptional activity 84396 363445 114208 25591 116590 50689 24666 50554 64156 297893 25631 50522 81920 499929 361831 313757 29357 192255 100912032 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224163 PI3K events in ERBB4 signaling 25513 25433 432361 498596 170911 64022 59325 SIGNALING BY WNT%REACTOME%R-RNO-195721.1 Signaling by WNT 680149 688319 117281 58979 25023 24244 287102 114117 24400 80722 293897 295445 502097 114107 81667 24681 24680 363875 83800 116561 54241 312754 116563 299147 297893 289878 688297 307401 24185 25233 29748 100361818 24674 304794 24675 81650 25578 290829 81717 362093 102550344 116549 85252 113927 365901 315294 288666 362550 314212 289883 287357 114850 316526 362065 303586 306782 84426 361846 100360552 266715 58822 114487 497961 140584 50664 291678 287772 292766 304832 65046 64156 301965 161452 29669 64558 140670 29668 120099577 117273 79257 29425 503000 100360846 501584 29382 498997 498233 117263 25400 25581 691857 63879 29666 103691373 291209 303353 679110 365388 65027 25565 295251 117262 85492 364754 289026 29417 312451 84027 287984 29134 65138 24881 94198 310704 684097 64512 317674 29673 301555 300837 25388 313589 29671 312936 29670 309419 29677 308051 29676 499918 29675 299802 84353 50522 679158 282581 100360606 290317 266772 500863 81827 246768 360990 84424 303251 83806 303412 311078 364712 192255 303811 293165 287280 24205 361765 140585 100912032 83721 140586 64199 300673 24525 315648 79218 245986 690516 60449 64303 363193 294962 309179 313121 24673 83579 24672 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation 367090 680915 315344 303175 365877 64627 306970 690795 302783 24829 24828 290232 297758 81528 170841 500054 306945 307798 307861 685909 680615 305957 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%10222977 Glutathione synthesis and recycling 360994 25283 116684 29566 156275 362196 408206 116568 25458 291394 29739 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222633 Mitotic Spindle Checkpoint 114764 29564 117281 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 305270 83572 140734 681050 58945 684439 296368 64515 297176 361389 312754 114592 294429 288671 287830 290875 299147 292085 25515 24669 305420 361831 366381 292588 293155 297522 81738 683983 360643 315648 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363193 363028 309179 315164 24673 304951 289150 361416 363174 81655 303037 363059 24672 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-RNO-6799990.1 Metal sequestration by antimicrobial proteins 170496 301034 94195 116547 MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-RNO-2555396.1 Mitotic Metaphase and Anaphase 117281 64158 25573 301442 316531 296554 365191 312754 29213 294429 287830 291874 113975 299147 292085 295692 684771 117021 362335 305343 304218 366016 290577 24669 362557 297522 81738 683983 306464 679342 287624 291441 25437 257649 257644 64041 25448 682908 94266 29489 307351 282834 363028 291081 364419 500377 315164 307833 304951 363720 361916 289150 246118 361416 363174 84509 500363 81655 303037 313478 679312 287873 300218 363059 114764 246772 29564 679886 498736 286993 114514 114087 298850 362700 83836 363198 362548 304477 298594 170845 252902 85252 117104 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 24917 317252 363481 305270 83572 140734 681050 58945 684439 287772 292766 64156 313304 296368 29669 29668 63996 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 287984 65138 94198 25515 29673 116685 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 292263 500929 25203 83806 311078 192255 100912032 360643 315648 363193 309179 24673 24672 PHENYLALANINE METABOLISM%REACTOME%R-RNO-8964208.1 Phenylalanine metabolism 29700 246307 64192 100360621 311844 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 96%10223381 Regulation of KIT signaling 24680 116689 25150 313845 114203 60427 64030 81515 313050 83805 500985 81504 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223683 Prostacyclin signalling through prostacyclin receptor 292661 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors 25023 363447 171571 84591 65046 140670 24681 84016 24680 116563 29629 29628 29627 50592 60355 MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing 301226 498251 25383 81635 25367 170912 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%10222527 Activation of caspases through apoptosome-mediated cleavage 25402 64026 63879 690675 78963 58918 25309 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 96%10222139 Eukaryotic Translation Initiation 192234 299027 54318 117019 296302 64514 171145 83789 291434 81729 25347 28298 64205 26962 94266 100910714 64298 108348073 290641 361923 134480579 117042 287122 499782 308306 140661 292762 140662 29257 682390 298700 25348 300079 691947 362952 292964 81775 293418 81776 299872 81773 81768 81774 293427 100361974 288599 303831 65136 362631 691531 27139 288516 294282 360572 122799 245981 29236 681429 497860 117053 81770 100362640 64156 161477 292148 64640 100361756 29288 81764 29287 29286 81765 29285 81766 299899 124323 140654 81767 81763 171350 29304 140655 29284 300069 293484 100361060 103689992 58927 122772 117045 29258 689284 116636 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10225261 Blood group systems biosynthesis 366064 81919 296564 84597 288161 100301568 58924 407765 363040 64445 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-RNO-8951430.1 RUNX3 regulates WNT signaling 156726 161452 84353 312451 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%10224725 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 680498 303175 83724 365877 24208 64627 298144 306970 500569 690795 310678 302783 24829 24828 117056 29355 306945 685909 680615 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 96%10224919 FGFR2 alternative splicing 292778 288588 29578 316123 689116 140931 83503 298075 500409 361365 690966 64200 117017 362950 29497 307810 361655 363633 498109 289561 MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis 24470 682974 29632 116700 25329 360348 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224033 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 293624 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%10224679 Transcriptional regulation by small RNAs 680498 365877 292778 308971 288588 690795 310678 83503 361365 302783 690966 24829 24828 117017 363633 498109 289561 117056 685909 680615 303175 64627 306970 686774 306945 84509 TP53 REGULATES METABOLIC GENES%REACTOME%R-RNO-5628897.1 TP53 Regulates Metabolic Genes 100188937 362045 54322 502894 29414 313017 24377 84683 292804 113898 65248 25309 56010 295357 64562 26954 360229 690675 117044 140942 117043 56718 360776 25520 303393 83803 308869 310091 298514 373545 64226 56011 297960 24855 29445 78975 654441 117254 29338 25282 26195 94194 26198 681024 24185 60445 29753 24398 25233 315427 688386 192268 102555170 116484 25576 25578 25577 502988 171335 252934 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-RNO-211163.1 AKT-mediated inactivation of FOXO1A 24185 84482 25233 29414 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%10222171 RNA Polymerase I Transcription Initiation 306274 362728 83582 690450 83581 310614 84389 361724 288651 361580 25574 297893 502227 294693 83503 690966 291703 301246 498109 117526 266713 83712 100362346 304714 313048 117535 361784 360893 361420 290669 362834 64520 313245 680493 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-RNO-373076.1 Class A 1 (Rhodopsin-like receptors) 360579 29581 171056 365228 306307 25555 29238 89808 81644 29595 81645 29237 192205 29235 192206 24221 29234 84475 29471 54226 171044 24318 102552838 360918 294123 314386 24797 294124 685243 24677 25524 25645 294121 114098 114099 25087 84023 294807 25653 25652 24323 24326 24448 81668 29335 301086 690158 367315 24659 266997 24772 114105 60628 25504 445269 309212 25187 171371 494319 497942 498475 192648 192649 246358 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 310444 25075 25195 192646 501177 301066 25726 113914 679957 287910 298006 171158 362454 498335 117041 25616 366270 366274 29538 117029 245920 83518 24889 266607 60669 60665 29413 29412 78976 25298 679975 54305 85268 302378 25706 170926 259224 259222 24613 25380 25264 24174 25265 363682 29180 288995 378939 691774 116677 29636 319107 64803 319105 24182 25033 29191 24180 287673 499194 113959 24717 25245 63843 25248 170704 117518 25007 260319 25360 58812 287561 287562 24604 63850 171104 171108 83567 310869 29290 171101 58949 116700 25329 24179 25601 25605 60337 379044 25593 500157 310327 78964 25723 29316 25369 25083 24175 29597 287730 24816 24938 25107 25108 25229 688605 689936 316019 29385 246075 282832 116498 25340 50672 25342 29141 292409 64042 53949 308408 25477 246759 29397 24260 25111 292419 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25449 29363 54258 84348 66025 306792 24232 298062 81752 60399 24473 310812 305236 116744 50577 29415 289023 29733 171551 500317 65032 24925 24807 24806 24808 24929 290493 292794 117549 316259 295144 192223 317219 25570 81503 29256 498289 362505 366668 100360071 497196 100911796 497078 25542 64636 302619 299242 117264 57305 353250 308163 84007 117027 57302 89810 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%10223635 Peroxisomal lipid metabolism 85239 84029 65183 64461 79244 308518 291075 363516 303577 50681 83842 83522 501072 65192 171142 114209 113956 25541 85255 307170 311849 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 96%10224229 Collagen formation 294279 25412 25654 300341 362584 315979 114200 25335 362285 367313 84352 363158 290637 83470 84032 363458 288583 365460 678743 24914 306628 287899 50654 25697 290905 685612 301012 290350 309380 554172 305253 315714 85490 315071 29569 353303 499431 314981 312115 81687 289081 60379 25681 29345 304021 25506 288016 64367 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%10224471 Sensory perception of taste 286924 500101 500089 100310876 500091 554302 24400 689869 78979 29407 60449 25122 78981 78980 170634 24768 78983 24767 78985 680188 690448 25679 246219 100270683 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 96%10224771 SHC-mediated cascade:FGFR2 29349 29348 24525 313845 25444 25443 54250 25317 170700 29369 29368 170633 60464 170583 116499 24605 60662 293621 170579 25022 85385 66017 81504 ION CHANNEL TRANSPORT%REACTOME%R-RNO-983712.1 Ion channel transport 24244 25650 297932 298103 29757 289407 362802 368044 296981 298451 299971 83615 170667 436582 25391 297566 25390 312488 117596 94170 29600 116664 366545 64672 24211 24212 24213 294141 689560 63847 312981 63848 58950 58971 64190 116831 59299 29639 29132 89821 24941 299714 679906 499287 362053 79430 83810 315272 303056 140933 79425 292168 192675 29465 66026 689991 29233 29232 308637 116601 367318 25749 304315 365266 171497 360932 171496 29599 29598 64156 361929 266730 306600 24768 24767 29693 25400 24245 171143 24246 171384 295041 114246 311396 301111 311287 293735 288026 171140 291555 63866 314401 293874 63882 297930 116469 25688 303856 24217 312896 50522 290673 314847 362645 291411 24703 286920 83514 192255 497948 361586 364973 79123 100912032 308015 294329 246215 689103 362247 25122 25364 292597 60395 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling 306790 316009 24553 361568 306400 25537 362993 363875 64373 117273 78966 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%10223323 Formation of the beta-catenin:TCF transactivating complex 310704 300837 304832 301965 297893 161452 304794 84353 691857 84424 290829 25565 295251 362093 29417 102550344 300673 312451 INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling 25326 313845 25746 25125 24918 25126 690369 85385 25670 81504 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%10223333 Phosphorylation of CD3 and TCR zeta chains 315707 25300 25710 64019 24986 24932 295338 294269 300678 313050 24981 24699 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10223445 Acetylcholine Neurotransmitter Release Cycle 25558 140592 84556 25012 116470 25531 24803 60422 85426 25716 64830 293645 64832 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-RNO-5626978.1 TNFR1-mediated ceramide production 83537 94338 83427 24835 25625 COMPLEX III ASSEMBLY%REACTOME%R-RNO-9865881.1 Complex III assembly 26192 293448 291671 691506 291103 497902 686506 685322 301011 300047 360826 102550385 366448 288740 120097699 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation 362045 360471 116549 29414 287155 287772 292766 64156 29669 29668 29425 100360846 83712 117263 291171 295357 25581 100362346 63879 29666 313048 117535 26954 303353 117044 365388 117043 290669 117262 362834 85492 56718 360776 64520 308869 287984 310091 65138 298514 94198 64226 688041 29673 310614 297960 361724 29671 29670 29677 308051 294924 315093 297893 50557 29676 29675 686412 50522 307151 81827 83806 313038 311078 296988 192255 309626 100912032 310258 24185 303730 25233 310306 291999 500572 315136 81650 79209 25489 501403 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-RNO-933541.1 TRAF6 mediated IRF7 activation 292892 293624 ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222329 Arachidonate metabolism 679520 287424 114097 287425 100911581 24404 24307 290623 266674 502969 298423 24886 25527 313375 25526 286904 59103 29224 24306 299566 503122 312086 84024 50549 287454 29527 29328 29624 81639 29277 299732 24296 24297 65030 25290 116568 25426 29566 362809 498790 296851 58962 94199 307092 310848 291283 361266 171516 307096 364773 498789 291984 266604 191574 24565 289014 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-RNO-3928662.1 EPHB-mediated forward signaling 360854 361882 64465 84009 81732 81824 54227 289820 293621 25614 25150 81822 297518 25676 25537 304109 81515 363875 29491 117273 288669 83805 24408 24410 29431 287876 25615 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-RNO-2467813.1 Separation of Sister Chromatids 117281 312754 294429 287830 299147 292085 684771 305343 304218 290577 24669 297522 81738 683983 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363028 315164 304951 289150 361416 363174 81655 303037 363059 114764 29564 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 363481 305270 83572 140734 681050 58945 684439 287772 292766 64156 313304 296368 29669 29668 63996 64515 29425 100360846 297176 361389 117263 25581 114592 29666 303353 365388 64193 117262 85492 288671 290875 287984 65138 94198 25515 29673 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 100912032 360643 315648 363193 309179 24673 24672 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation 24963 64226 79245 60460 24472 25420 286899 292887 301252 113906 25400 24245 24246 362809 260321 299331 24468 56718 171140 THE FATTY ACID CYCLING MODEL%REACTOME%R-RNO-167826.1 The fatty acid cycling model 85263 25708 54315 24860 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 100360427 304758 24790 116590 500715 50689 50554 64156 54281 680111 25631 50522 361178 81516 362110 29357 192255 300813 100912032 29417 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%10222623 Amine Oxidase reactions 308652 25750 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224961 ERBB2 Activates PTK6 Signaling 25433 25313 24329 432361 366275 498596 29496 64022 59325 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-RNO-418594.1 G alpha (i) signalling events 360579 171056 306307 25555 29238 89808 81644 689869 81645 29237 29235 170634 362477 29234 308118 84475 29471 54226 171044 360918 24797 24677 25524 81672 25087 294807 29335 690158 24659 266997 24417 24419 24772 114105 60628 24416 24415 309212 83633 500091 497942 363143 29481 246358 116637 25516 408199 310444 25075 192646 501177 500089 100310876 301066 679957 287910 298006 29407 78981 78980 78983 362454 78985 498335 29538 117029 245920 83518 246219 406163 29480 60665 54289 54294 54293 54292 54297 679975 54296 54305 498246 301088 78979 100361166 365901 59293 259224 114705 259222 246254 24613 362021 25380 289076 24174 690448 363682 64803 24182 25033 287673 113959 83805 24717 25245 63843 25248 170704 680188 58812 24604 502757 171104 171108 500101 83567 310869 29290 64199 24654 286924 83506 24611 315648 79218 360616 24627 24626 25638 81636 245986 25238 24179 24668 60449 25031 293508 302950 85240 363193 294962 64532 25521 25686 24673 25289 25643 25601 25725 24679 83579 29241 24672 680149 84420 117281 58979 116590 140908 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 81662 81664 60341 29691 25083 24175 287730 688605 689936 29385 282832 25340 554302 29141 60590 292409 64042 246759 29397 25111 292419 25323 81509 63887 297795 767613 25689 29363 54258 84348 66025 306792 24232 60399 305236 116744 50577 29415 171551 500317 24929 290493 117549 24247 316259 81503 29256 498289 362505 497196 100911796 81657 353250 308163 84007 117027 57302 89810 100270683 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events 117284 58948 24244 501560 25050 29699 171503 191573 60341 83506 81646 64053 81771 293508 24409 117269 24408 24410 25400 24245 25521 24246 24412 24411 29629 29628 29627 25725 83613 24679 29495 50592 25252 171140 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856828.1 Clathrin-mediated endocytosis 117106 84018 313934 117039 361244 361120 60668 117277 60422 317396 56084 81645 60568 311854 25490 60566 60564 24221 363466 25372 25716 29528 192152 25433 25313 24825 64678 312689 29491 25151 83800 116561 85491 54241 79128 140694 116563 83730 24329 313409 24468 29216 500985 64633 287709 79121 59325 29183 64022 314641 54225 288779 24803 81732 311880 289820 85238 192348 25108 116717 246310 297518 360915 65046 64156 116743 24180 64558 140670 288669 171574 24255 360854 310839 25387 25388 363273 363266 24805 81824 363283 50522 300678 65178 124461 25710 24932 81659 303251 114590 24807 192255 298598 683687 100912032 290639 292944 81504 313474 287367 266606 25751 314349 81922 361632 89816 192154 25238 310097 498798 81921 29704 85256 312694 360202 261736 24827 300438 117028 311030 84357 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224043 Negative regulation of FGFR2 signaling 117281 116590 25444 25443 54250 25622 29369 50522 29368 500526 306141 170583 192255 60662 170579 25022 100912032 66017 81504 29349 29348 50689 170700 25317 64156 314850 83805 170633 114486 60464 116499 24673 500985 24672 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%10224251 Synthesis of PI 192260 81925 361694 287467 304474 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 96%10222757 Cytoprotection by HMOX1 79239 363026 100188937 54322 292737 83724 84578 29445 654441 296732 25282 84683 365755 302711 26195 94194 24451 26198 681024 312947 25747 688386 25309 311545 24186 102555170 497991 690675 360229 24440 171335 360504 24565 303393 24360 252934 116599 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%10224553 HSP90 chaperone cycle for SHRs 29564 294010 25672 24472 24208 65028 361810 252902 299850 362809 260321 25154 299121 140734 24963 58945 60460 24413 29489 301252 299331 29167 300721 84428 81655 24468 192277 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs 81639 299732 25290 29527 29328 79242 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%10224115 ISG15 antiviral mechanism 312688 25738 50689 298693 295704 292892 306204 116725 25489 114558 24667 54287 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 96%10221955 Transcriptional Regulation by TP53 290805 308755 497672 64314 114495 24484 64557 308986 363924 303194 315969 64046 85482 192218 114212 685055 310034 306734 305000 25309 170824 300711 297627 690675 360588 497856 64012 294800 498411 291787 24855 100361529 140583 24942 26195 26198 24185 60445 29753 25233 685474 25576 25578 25577 307511 311575 29414 313017 304798 58936 113898 81745 64525 64156 316034 140923 305025 686781 114592 54237 58983 140942 303393 282845 295052 29445 117254 291773 50522 317256 29338 83722 170844 171152 309638 288533 25203 373541 685619 364298 293345 294018 192255 288003 117526 114494 291841 287571 25737 94194 100912032 299694 288414 116468 681024 292064 115771 315648 315427 81807 287249 102555170 116484 24673 502988 171335 24672 100188937 362045 54322 360471 117281 140908 502894 171355 116671 305837 683593 24377 84683 293625 312227 314862 292804 313777 295707 134478826 363603 360229 25405 311546 314818 24842 301513 56011 25533 304758 362479 192350 282844 500715 683469 81785 297893 306998 362675 654441 362110 25282 246334 688386 289372 311613 266713 363221 689820 306571 363292 81650 362272 29619 306492 252934 315210 292778 679713 116549 84389 288651 288588 361580 316123 502227 294693 83503 311796 361365 690966 117017 305455 679203 291703 363633 362485 498109 289561 59102 83571 290744 65248 56010 83712 295357 64562 314621 313048 26954 117535 117044 117043 290669 362834 56718 360776 25520 83803 308869 310091 298514 373545 64226 297960 310614 361724 78975 25498 24398 315189 192268 296648 116723 89812 310131 361374 140607 INTRA-GOLGI TRAFFIC%REACTOME%R-RNO-6811438.1 Intra-Golgi traffic 314030 54400 64516 310411 500906 367308 64351 291990 362283 140673 690961 116692 65277 116691 313493 100359675 60562 315668 64621 64154 293456 94189 64310 361073 60355 365793 65134 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222377 RNA Polymerase III Transcription Initiation From Type 2 Promoter 690254 685539 306012 83503 690966 301246 294687 498109 362095 117526 114205 316810 311487 310685 361102 685465 313914 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 96%10223437 EGFR interacts with phospholipase C-gamma 29183 25738 25433 25313 24329 24827 64022 59325 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 96%10223269 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 24185 81646 294515 25233 116590 83571 29414 85252 246332 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-RNO-196780.1 Biotin transport and metabolism 170551 288240 25104 306262 294972 361884 687008 60581 PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 29349 25444 54250 361388 25622 25317 170700 314850 289625 29369 29368 60464 25513 170583 170582 116499 170911 25114 66017 81504 PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair 116484 685059 361286 29447 25604 SIGNALING BY NTRK2 (TRKB)%REACTOME%R-RNO-9006115.1 Signaling by NTRK2 (TRKB) 25150 24225 313845 25738 315992 314850 25730 25054 363875 81504 HOMOLOGY DIRECTED REPAIR%REACTOME%R-RNO-5693538.1 Homology Directed Repair 311860 290805 308755 497672 293452 64557 304719 83508 363924 299112 102551085 303194 315969 498119 499966 290997 64046 290631 316794 171366 171525 304573 85482 289777 287634 59102 192218 293489 298098 298534 287927 685055 310034 297561 25573 361815 64156 306734 305000 499417 362385 300711 299638 302982 690043 288079 297627 316235 296099 360588 497856 302953 64012 499870 294800 293678 290027 498265 84490 25591 498411 308669 295052 291787 289468 100361529 689055 50522 297486 140583 362827 84495 24829 362704 192255 288003 114494 361698 25737 100912032 288414 289758 116468 59294 89809 303175 64627 116725 306945 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-RNO-388841.1 Costimulation by the CD28 family 117281 116596 315707 116689 25513 497932 246273 366508 170911 361992 60664 85243 298947 29433 497931 363875 312754 299147 64465 25622 310678 315606 302783 24829 24828 117056 685909 680615 24185 303175 407756 25233 64627 366962 306970 304794 81650 290829 58919 306945 362093 680498 365877 116549 29414 690795 360640 499415 81745 287772 292766 289874 64156 94201 29669 290783 81515 65248 29668 362040 83805 56010 29425 100360846 116967 83712 290823 117263 192275 25581 407784 64562 29666 313048 100188932 303353 116643 365388 309304 290638 686092 117262 85492 56718 301626 25520 83803 84027 287984 313648 65138 362891 94198 64226 373545 688041 363160 29673 301555 499342 29671 287643 29670 64701 29677 690315 29676 78975 29675 360967 294269 50522 300678 313050 24981 25300 25710 24986 81827 24932 83806 311078 192255 287280 361765 100912032 81504 25150 315648 315189 296648 25660 363193 29431 310131 309179 25408 24673 64545 56822 29432 24672 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%10224799 Formation of xylulose-5-phosphate 290277 171408 24788 78959 316067 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 287662 310258 499874 688041 313978 297093 361178 309457 140583 307151 83712 100362678 313048 309626 60661 300320 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222851 Interleukin-17 signaling 315994 117281 116590 315305 114495 501560 116596 116554 362418 300980 308267 50522 50658 317546 81736 116663 309361 60587 303024 192255 287280 361765 100912032 315648 81646 50689 81647 64156 116725 314322 311245 309295 81771 117269 363193 500133 363520 24673 313121 362491 363855 25272 84351 24516 289014 24672 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222047 Aspartate and asparagine metabolism 367181 25612 79251 300384 362322 246266 85309 25721 24401 289727 IRON UPTAKE AND TRANSPORT%REACTOME%R-RNO-917937.1 Iron uptake and transport 79239 64831 50522 25490 170496 297932 298103 50655 192255 29757 289407 287280 362802 368044 100912032 296981 24451 298451 299971 83615 25715 295669 170667 436582 297566 117152 312488 291470 117240 117596 94170 116664 366545 64156 24825 499991 64678 170824 29199 288562 29292 170840 305886 312382 25319 303333 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%10225391 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 287984 65138 94198 29673 29671 29670 29677 83619 29676 29675 50522 81827 83806 311078 192255 287280 361765 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222023 Glycogen synthesis 690987 81675 309513 MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis 311860 361432 29148 83501 360715 309957 84382 171046 360600 64465 50938 84353 60352 499497 297357 337868 25714 81518 498607 25720 299766 XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%10222317 Xenobiotics 499353 288517 308445 24894 24299 502969 29277 171522 24895 25086 25242 313375 25243 24296 498999 24297 266682 252931 54246 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-RNO-425397.1 Transport of vitamins, nucleosides, and related molecules 296578 116642 310808 353307 63997 65142 94106 25239 64018 313139 311839 65194 65039 291582 296969 170551 60423 25176 140944 680602 498910 311204 85333 306866 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222783 mTORC1-mediated signalling 310091 298514 362045 64226 116636 25435 297960 83840 292887 295357 29304 26954 117044 117043 117045 56718 360776 25639 308869 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-RNO-9730414.1 MITF-M-regulated melanocyte development 116590 292028 353305 29414 360034 297893 361604 29361 290868 85252 84353 291624 306804 25017 117516 116483 287191 288480 289352 60427 170577 25094 690660 309757 25573 50645 50689 161452 301442 81771 64030 84027 312451 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224635 Positive epigenetic regulation of rRNA expression 306274 368002 680498 362728 83582 690450 83581 365877 690795 310678 83503 302783 690966 24829 24828 301246 498109 117526 117056 317399 685909 680615 303539 303175 64627 301164 306970 60571 65261 306817 287876 361784 360893 361420 306945 313245 84027 84486 680493 PLATELET HOMEOSTASIS%REACTOME%R-RNO-418346.1 Platelet homeostasis 140448 54225 117281 140928 24244 313611 308899 113995 116689 25041 29691 29659 81739 81743 25262 116601 25391 29583 54286 29599 29600 29598 81678 191569 25523 29693 312754 362558 25505 292661 299147 25622 114115 79113 29715 315648 24600 63885 24598 29665 363193 309179 171115 24673 60395 24599 25679 140447 24672 MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling 309175 287984 65138 58840 84482 94198 64551 313838 64465 29673 360635 29671 29670 84009 29677 29676 29675 85252 50522 310806 81827 294515 83806 25193 311078 192255 100912032 287772 292766 29433 64156 29669 363875 29668 29425 293508 100360846 117263 25581 29431 29666 54237 303353 365388 29432 117262 85492 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223241 Regulation of TP53 Expression and Degradation 360471 117281 64226 295052 282844 29414 50522 304798 192255 114494 100912032 114212 115771 24185 315648 25233 81745 315189 64156 296648 300711 310131 24673 54237 25405 56718 311575 24672 24842 282845 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%10225069 MET interacts with TNS proteins 24553 303517 24511 24446 LIPOPROTEIN METABOLISM%REACTOME%R-RNO-174824.1 Lipoprotein metabolism 292697 54225 310900 25080 25081 362850 291437 303796 24530 83470 81782 24539 65046 64156 315218 54281 266732 140670 502970 83800 100361444 54241 140638 116563 300027 314459 266770 58851 25292 680551 80848 50522 25073 294930 192255 298296 100912032 313210 25507 24186 116548 293508 306825 300438 287276 25649 25506 24153 25728 AGGREPHAGY%REACTOME%R-RNO-9646399.1 Aggrephagy 24255 140734 29564 58945 64156 116725 252902 50522 29489 117287 192255 81655 100912032 56816 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-9617828.1 FOXO-mediated transcription of cell cycle genes 84482 294515 29357 24370 50554 302415 25631 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism 300328 361836 170551 29142 298490 287711 50671 171053 360639 363069 296167 294088 360511 INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling 117281 116590 114495 170538 116689 312688 25738 309361 64511 25318 301442 54281 312754 24468 89829 24842 24472 25622 361810 24697 359726 120103159 298205 502959 100361294 298210 24481 686326 120103158 100911527 690894 305896 288264 170897 500538 295704 313017 24917 64156 300772 25400 24245 24246 310968 54237 171140 300955 362678 117063 314172 50522 362050 24667 54287 306231 691105 84472 171164 360697 304859 24703 63880 499155 116465 81746 25712 24514 81635 192255 298693 304266 306204 304545 291978 100912032 24649 114558 29219 25498 24963 501552 81822 502320 315648 60460 303742 25125 50689 116725 309295 24673 287876 311130 292892 311430 363006 84351 25489 24672 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) 287984 65138 94198 116549 301555 29673 499342 287643 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 287772 292766 64156 94201 29669 29668 56010 29425 100360846 81650 117263 25581 29666 58919 303353 365388 117262 85492 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) 246772 679886 108348178 56084 362118 50522 287645 687208 297995 192255 292925 290635 100912032 290775 681059 64156 498798 282834 365191 364419 363720 361916 362502 287873 311030 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222095 Phenylalanine and tyrosine metabolism 29700 246307 29383 64192 29531 681913 100360621 311844 24813 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10225433 Mitochondrial protein degradation 293448 641434 192241 171374 113965 65262 309441 81829 353231 314304 25176 299857 54226 63864 307270 361596 361755 79250 170587 24368 25557 114096 29215 360975 303746 289950 298942 365699 65155 25618 63868 297376 503049 298079 83474 170916 361338 117099 300786 24450 29539 26195 94194 690163 293655 50559 24399 688685 291671 497902 307350 64526 25014 301458 29611 300677 94271 64539 252934 26197 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-RNO-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands 360579 362454 25380 54226 690158 287910 292419 292409 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224187 Tandem pore domain potassium channels 116491 84429 59324 170899 688996 116489 445371 64120 65272 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 96%10225457 Regulation of endogenous retroelements 680498 365877 689883 690795 310678 302783 24829 24828 102546572 361487 117056 100909569 685909 680615 290270 303175 120095871 64627 306970 24522 300266 680155 366975 102556967 365192 306945 108348224 690559 246264 116698 100362170 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%10225093 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 50662 361391 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases 116510 306404 25335 362347 63849 29175 25052 65205 299606 24291 83513 24691 29268 29543 25627 117061 85253 290257 54281 683849 291848 300338 81687 81707 81686 25481 103690254 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225475 SLC15A4:TASL-dependent IRF5 activation 309361 501570 84351 246280 309295 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-RNO-202433.1 Generation of second messenger molecules 366962 81511 363577 300955 29433 294269 300678 313050 24981 25300 310727 25710 29337 24986 499537 24932 29431 25738 29432 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 96%10222021 Biological oxidations 499689 24307 290623 266674 24894 24299 502969 24886 298423 24895 63867 25527 25242 313375 25243 498999 498940 286904 24306 299566 290681 503122 54246 116632 116631 171178 50549 300981 113992 25035 25279 114700 29277 171522 25086 24296 24297 266682 252931 308190 24172 25426 362809 266761 266685 501907 286954 94199 286989 312495 310848 291984 24902 24912 300983 24188 64473 64305 288617 297433 360268 361510 503103 58953 312952 83783 171072 292915 308652 308445 80773 25750 313786 25429 29680 79122 25428 246232 83472 60351 301517 83724 362782 499353 288517 25331 290401 64352 408206 116568 295037 291394 81869 25260 360994 494499 25283 298079 29566 29487 681913 156275 29539 297029 362196 24421 25256 24423 24422 25458 29739 24424 24426 310201 309465 246245 113902 293653 494500 57300 116684 501110 171451 58962 100145871 78959 303953 296259 171341 25315 683630 291084 81522 171445 29473 171347 690050 26760 29443 25375 24267 304078 140925 310903 290947 84493 29189 301252 293779 353317 246263 688536 361637 24861 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization 29748 313845 24244 100361818 366962 81511 363577 24674 24675 81515 361400 305311 84492 29337 25738 100360919 85385 295378 25155 81504 367901 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223789 Sodium-coupled phosphate cotransporters 25548 81826 246234 29502 84395 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-RNO-196854.1 Metabolism of vitamins and cofactors 25592 24244 499330 316062 25668 24778 306262 361300 29142 50671 171053 367323 85496 499328 64392 293504 300886 297508 300328 25104 353255 64845 313241 313520 29319 361751 311536 24539 25035 691984 361472 687008 171517 25551 24710 100125370 25703 24856 361836 289095 25702 170551 25680 288240 192259 301221 25523 116673 24771 64533 299858 293154 362558 29723 24312 300027 64047 299331 81506 314459 317322 25236 361884 296972 362134 299699 29216 25216 83578 291939 315644 680308 25615 303333 58920 362657 314941 751787 25056 55939 64300 315085 295229 294972 25732 298653 80848 363118 305248 50622 54349 60581 50621 365699 316559 362942 305889 680668 303676 289175 24185 498790 64001 24600 307092 291283 361266 171516 307096 364773 498789 191574 25649 25728 292697 54225 25080 25081 299857 365592 296128 498332 366013 299195 25249 24479 313521 29309 29244 308453 498909 29498 171128 304542 50655 360887 29270 298490 287711 360639 363069 296167 294088 360511 309465 81522 290947 313706 25571 399684 309004 24565 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling 292697 54225 310900 25080 25081 24539 362850 291437 315218 24530 54281 25507 116548 24186 502970 100361444 140638 300027 25649 25506 25728 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10223297 CREB phosphorylation 117269 81646 315305 501560 289014 81771 PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding 29374 116549 24818 299809 297406 288305 24400 54296 294864 170897 60449 81667 295230 29481 81650 294962 64013 363658 83579 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol 83789 291317 291434 81729 25347 28298 313707 305258 360828 64205 26962 289809 313167 94266 310720 300092 100910714 363134 362967 64298 289810 290641 296865 192180 359727 303608 362214 360552 305076 314617 310019 315705 85432 366017 60373 361923 134480579 117042 102551819 287120 287122 291987 499782 294975 297685 64462 291061 140661 140662 29257 362902 25348 362229 300079 291996 292964 81775 293418 81776 317399 290660 81773 81768 81774 291071 100361974 314713 65136 362631 679140 691531 27139 360574 313744 58822 294282 360572 361262 122799 245981 29236 681429 497860 117053 81770 100362640 300045 64156 161477 308201 290556 64640 100361756 361159 29288 81764 29287 686999 29286 81765 29285 81766 114021 124323 140654 81767 81763 29304 140655 312706 300050 29284 690297 100361060 103689992 309301 58927 122772 29258 293828 292747 689284 288647 100360664 368084 316317 307850 29283 29282 296709 289740 64302 64306 314830 100360439 64307 50522 298065 314545 361452 134486107 362703 361977 363237 362426 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation 498416 313845 25467 116590 29376 50689 24506 24505 85385 81504 MRNA CAPPING%REACTOME DATABASE ID RELEASE 96%10222335 mRNA Capping 292778 288651 84389 288588 291534 361580 316123 689116 502227 266713 294693 83503 298075 361365 690966 117017 291703 363633 498109 289561 313131 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival 81736 25493 24596 363520 113894 310738 192255 64156 311245 50522 100912032 84351 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223759 Golgi Associated Vesicle Biogenesis 25387 641528 24803 192243 295217 83576 81659 364183 317630 363476 683687 287709 140673 296199 192152 25751 25306 361632 89816 116743 295171 64678 25151 83800 29292 85491 288785 362609 54241 100362805 689256 312694 83730 294900 64310 313409 289312 24468 310746 25319 306332 S PHASE%REACTOME DATABASE ID RELEASE 96%10221915 S Phase 292058 307639 499914 290842 680014 691979 84490 684771 305343 304218 290577 24185 25233 266713 58919 84389 29414 295596 299112 312538 316273 296178 313479 362485 291927 360621 304573 308937 59102 29728 298098 292071 83571 301430 288532 366275 287772 292766 313138 64156 313304 94201 296368 29669 171102 29668 63996 362385 29425 100360846 499655 307585 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 24708 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 288003 114494 287280 361698 25737 301323 100912032 288414 360643 289758 116468 171103 59294 89809 85241 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-RNO-8951671.1 RUNX3 regulates YAP1-mediated transcription 156726 308582 363014 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis 316583 305571 84400 362275 84468 293667 367145 307859 362924 314771 64507 313536 494342 81682 58968 65196 290638 295934 363040 64442 64445 291015 303923 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 96%10224909 Signaling by MST1 311331 292770 29135 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 96%10223379 Signaling by SCF-KIT 25622 24918 25126 313050 140583 116689 24680 25513 60427 24605 24514 293621 170911 361597 60664 84477 81504 24525 25150 498416 114203 313845 25627 25125 366962 81515 363875 83805 84492 301737 81687 64030 363616 84427 500985 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10222939 Downregulation of TGF-beta receptor signaling 81810 29591 64156 25631 50522 81516 29357 192255 287155 297699 83837 100912032 59086 PYROPTOSIS%REACTOME DATABASE ID RELEASE 96%10222541 Pyroptosis 25402 679886 353316 116502 25309 171528 282834 365191 364419 24493 690675 363720 361916 299606 287873 29197 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223963 Highly calcium permeable nicotinic acetylcholine receptors 25590 81721 79557 25103 170945 54239 171131 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis 288525 363109 297393 294400 498272 291095 297417 310935 498486 299346 305291 360518 302972 81759 501167 25547 300741 311530 302915 300089 316642 116696 298071 117523 365984 303692 363103 25280 117185 304860 301155 291325 407765 363040 64442 64445 287920 29758 316033 114711 364901 83505 313139 25197 362924 311204 81726 296394 298541 311847 502017 293587 29640 295051 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-RNO-5173214.1 O-glycosylation of TSR domain-containing proteins 500032 314655 294809 364630 362539 308787 361886 293004 310670 361412 312566 315879 361332 300474 300475 445442 66015 292406 287899 102554393 299314 315728 305253 474348 306664 315263 304135 171569 310207 297757 64456 MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis 498265 362960 289777 499870 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-RNO-174084.1 Autodegradation of Cdh1 by Cdh1:APC C 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 100912032 360643 287772 292766 64156 296368 29669 29668 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225137 SLIT2:ROBO1 increases RHOA activity 117273 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%10222817 Activation of C3 and C5 24233 406161 24232 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224091 Activation of G protein gated Potassium channels 116649 680149 50599 58979 29713 79218 29712 83633 29718 114117 116560 24400 245986 60449 81667 294962 81657 83579 64199 25743 170847 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222957 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 114494 100912032 360643 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 29666 54237 303353 365388 117262 85492 288671 290875 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity 81922 64156 116743 56084 296121 117063 498798 50522 81921 24697 24553 192255 100912032 312574 311030 24446 500985 81504 313474 84357 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223777 Small interfering RNA (siRNA) biogenesis 64028 311130 298533 299284 363006 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-RNO-2243919.1 Crosslinking of collagen fibrils 365460 29569 678743 290350 24914 309380 554172 83470 315714 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%10222353 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 171365 100362099 680737 366468 681031 687711 681062 689116 501688 298075 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 96%10222923 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 25591 304758 116590 500715 50554 24666 297893 25631 50522 361831 362110 192255 100912032 100360427 363445 84396 114208 24790 50689 64156 54281 680111 81920 361178 499929 81516 313757 29357 300813 29417 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 96%10223345 G beta:gamma signalling through PI3Kgamma 680149 24185 58979 79218 25233 81745 298947 114117 29414 24400 245986 497931 60449 117273 81667 497932 294962 83579 64199 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 96%10224137 Antigen processing-Cross presentation 365527 287984 65138 94198 29673 29671 29670 29677 29676 29675 680842 171105 81827 64630 79129 414786 83806 502852 311078 498011 24750 295279 29468 29528 296456 287772 24223 292766 24974 29669 29668 29425 499400 66021 100360846 117263 25581 24988 29666 83730 303353 365388 24968 117262 24967 85492 291983 29614 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%10222523 Inhibition of replication initiation of damaged DNA by RB1 E2F1 117281 85241 315648 682033 24673 301323 24708 24672 INTERLEUKIN-35 SIGNALLING%REACTOME%R-RNO-8984722.1 Interleukin-35 Signalling 29144 25125 680609 24514 84405 100361294 171334 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 96%10222667 Peptide chain elongation 29565 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%10222125 tRNA Aminoacylation 310856 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%10223447 Synthesis of PC 29194 116549 298504 296128 25511 295417 294255 286936 140544 363024 81650 85254 361467 316737 310773 29510 29367 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%10222259 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 292778 84389 288651 288588 361580 316123 502227 291773 294693 317256 83503 83828 170844 361365 81673 690966 83830 171152 117017 309638 288533 373541 291703 293345 363633 294018 498109 289561 303918 117526 287571 266713 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-RNO-2142700.1 Biosynthesis of Lipoxins (LX) 114097 25290 287454 29624 79242 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface 24941 84355 316519 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 100912032 360643 287772 292766 64156 296368 29669 29668 64515 29425 100360846 361389 117263 25581 29666 303353 365388 64193 117262 85492 288671 290875 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 96%10224803 UCH proteinases 311026 365877 64557 315523 25490 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 24919 85492 287984 65138 94198 315723 29673 29545 29671 29670 29677 26295 29676 65137 29675 50522 64646 304298 24828 81827 306257 502125 83806 311078 291737 192255 100912032 680615 296084 361925 85423 498560 293494 306970 360853 287876 316440 362258 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-RNO-379716.1 Cytosolic tRNA aminoacylation DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%10224595 Depolymerization of the Nuclear Lamina 24680 25023 116685 25203 54237 25437 316737 287447 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%10225429 Specification of the neural plate border CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%10222479 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 83506 60341 24244 25050 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction 25622 300955 24918 25126 25414 25513 25738 24605 287942 293621 170911 25267 85243 54245 25266 81504 24525 24629 24628 313845 316369 25125 25676 83805 84427 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%10223571 Enzymatic degradation of dopamine by COMT 308868 24267 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225085 RUNX1 regulates estrogen receptor mediated transcription 50662 24890 361391 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 96%10221991 Regulation of TP53 Activity 290805 308755 117281 360471 497672 140908 114495 64557 171355 363924 116671 303194 315969 305837 683593 64046 85482 192218 114212 314862 685055 310034 313777 306734 305000 300711 297627 360588 497856 64012 25405 311546 294800 24842 498411 282844 291787 81785 297893 100361529 362675 140583 246334 24185 25233 685474 289372 311613 689820 306571 363292 81650 362272 311575 315210 679713 116549 29414 304798 59102 58936 290744 81745 64156 305025 65248 83712 114592 64562 686781 313048 314621 54237 117535 290669 362834 56718 25520 83803 282845 64226 373545 310614 295052 361724 78975 50522 291773 317256 170844 171152 309638 288533 685619 373541 364298 293345 294018 192255 117526 288003 114494 287571 100912032 299694 288414 116468 115771 292064 315648 315189 296648 116723 89812 310131 24673 361374 140607 24672 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling 24244 170538 502902 64171 308267 317546 81736 117553 25493 309361 83477 307366 360640 303024 81745 287772 292766 64156 29669 29668 83805 29425 100360846 29337 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 361831 81827 83806 311078 192255 287280 361765 100912032 29748 641452 100361818 24674 116725 24675 311245 361400 309452 282817 309295 64044 313121 84351 MMR%REACTOME DATABASE ID RELEASE 96%10224651 MMR 59294 81685 81709 361698 25737 305000 59102 289758 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 96%10224491 Processing and activation of SUMO 308384 103689978 78973 690244 25573 690251 301442 499417 304132 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%10222451 Transport of the SLBP independent Mature mRNA 113975 292085 295692 117021 362335 366016 689116 58958 362557 298075 65274 113929 297522 245922 81738 683983 53372 25497 499974 59087 690585 294429 117045 287830 291874 362281 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 96%10224099 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 116649 680149 50599 58979 29713 79218 29712 83633 29718 114117 116560 24400 245986 60449 81667 294962 81657 83579 64199 25743 170847 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10223565 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 64466 299810 25573 116700 24577 25329 114491 314993 301442 24890 114490 306817 313596 291772 304809 25498 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-RNO-159236.1 Transport of Mature mRNA derived from an Intron-Containing Transcript 298385 360726 361814 689116 360972 298075 295284 362819 313449 305714 361859 313308 361990 688288 294429 315170 361542 288701 287830 291874 362281 113975 296219 292085 114612 295692 117021 362335 366016 58958 362557 303057 65274 494445 113929 89827 29667 297522 245922 81738 683983 362687 53372 25497 499974 687575 362098 689890 259170 79227 59087 690585 501621 690303 290519 287113 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism 84018 294324 298504 25511 286936 295417 140544 288025 362434 316039 680971 114101 65038 498741 366196 25513 497932 288322 289733 296048 287115 361467 296623 362058 362039 85311 366508 691905 287366 54259 314075 29354 24913 60666 170911 60664 363159 29692 681694 308309 295631 85243 170919 361433 298579 29526 313997 29359 690610 297694 362249 290843 293711 361686 311821 691478 305166 298947 497931 362972 678749 84497 252900 116482 192259 307428 287533 64633 295674 114089 301131 305935 246237 293620 282584 308584 314553 367786 289021 360521 310663 114561 361676 306490 361659 305482 312634 310773 94197 29367 89841 360843 29194 361401 311341 81650 314641 84470 64310 29510 306460 360753 60418 300147 500132 116549 25532 171088 140940 85238 81747 29254 364629 116720 25062 363521 362702 296130 29653 25096 25097 361694 287467 304474 192260 81925 498331 296128 309419 50557 363024 364298 305419 288762 361632 294255 363131 114554 307842 116699 309855 116723 316457 80849 89812 65052 310155 171155 85254 360426 170670 317296 316737 302425 365865 140607 PROTEIN HYDROXYLATION%REACTOME%R-RNO-9629569.1 Protein hydroxylation 266670 124323 305470 29304 362154 308976 100137086 293418 314300 307503 360665 26962 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs 300147 288779 25531 313340 29414 299075 316017 311880 292074 114638 367915 315999 362983 315756 84379 25530 501550 289350 360768 363235 691042 288700 307868 689102 64633 292760 311494 501854 315059 25183 29662 312257 362599 117103 299799 307039 363123 290746 361987 294709 171452 363326 306229 360827 287427 94193 24942 287709 94197 361555 24185 29753 25233 252916 84590 50645 367073 313493 246324 29448 295333 207119 81754 315668 81756 680465 29885 84589 308942 309678 360797 266688 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 366381 292588 297176 361389 293155 296368 360643 288671 290875 64515 305420 361831 HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism 24782 300993 404783 367166 24434 294673 500052 64152 282821 25694 116721 363103 266805 300757 25406 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%10222559 Platelet activation, signaling and aggregation 499913 24795 25023 114095 24791 301512 311795 25651 84491 83785 307396 114111 89811 360457 497932 246328 303634 54226 299909 360918 309207 81809 170924 59086 25262 295378 29302 63836 25524 60327 25717 293676 25087 294643 363104 113947 24825 691992 25259 25373 364206 64465 24697 25414 246358 59326 361714 24185 84590 85253 25578 24153 116510 24174 25265 29636 64803 81745 81515 117273 83805 25387 25388 313050 24854 24703 295703 64199 25155 286924 79218 245986 60449 294962 25686 25643 83579 680149 24617 58979 116590 24244 170538 81511 114117 24400 81666 81667 24681 315707 24680 116689 81662 25513 81664 24366 24367 170911 60664 85243 54245 85385 25313 298947 24189 497931 363875 685269 316531 25083 24175 305679 295347 24446 25622 29434 25266 171337 24628 24186 24936 293860 309609 360942 24944 25081 305021 54248 56782 81634 361196 54249 363015 24648 81749 500152 688705 100359512 498299 445442 24816 29254 686539 308875 116727 29583 29340 116498 363195 81678 305795 29337 302470 307986 24786 116635 54404 312159 360950 140656 296488 24614 81803 81804 29186 502858 54320 64373 245955 315989 304983 500336 81814 684555 81821 116662 140866 100361138 140594 81504 25614 309186 681544 25150 313845 293628 50689 50693 25441 682967 293886 24483 24482 94168 289316 25666 287876 60395 304805 308291 25679 497978 25673 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%10223607 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 266607 171101 25253 302813 294075 25608 CILIUM ASSEMBLY%REACTOME%R-RNO-5617833.1 Cilium Assembly 117281 363272 171044 64158 311573 311802 311529 290626 365153 300963 362553 315423 296618 170714 683722 314523 29479 500086 363055 299209 100910342 305467 24818 366403 685284 298767 64632 367153 288305 360672 300062 308064 363544 294864 373066 365770 252921 311123 316102 499814 314961 304007 293844 60627 100362495 295230 316531 288585 300675 171455 296554 85258 500571 24650 363286 310344 116654 287541 313365 252881 314787 363760 498095 60347 50556 246150 295106 29214 363126 299331 500069 361789 113948 29213 245709 81740 192228 64664 25411 307347 305882 500832 315484 311456 29374 299246 114089 362142 679894 305287 367714 299809 287612 361930 65209 117103 307724 100362124 305349 303968 295654 116475 289168 689779 312651 366872 503018 308923 362265 680407 287383 300880 85248 303915 293148 296136 313170 287836 117515 361727 266809 29753 309486 81830 29489 29885 309451 114764 79120 83836 299850 64462 311191 308443 83572 140734 58822 58945 24717 56010 54237 29167 294010 83567 25515 25273 24679 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%10224547 Deactivation of the beta-catenin transactivating complex 310704 312936 297893 85252 84353 50522 679158 290317 246768 84424 364712 192255 293165 24205 361765 100912032 140586 300673 24185 25233 64156 161452 304794 120099577 503000 29382 25578 691857 63879 290829 65027 25565 295251 289026 362093 29417 102550344 312451 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 96%10224901 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 134478826 140923 170824 300711 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223021 Retrograde neurotrophin signalling 54241 59109 310738 116563 300078 65046 116743 140670 83800 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%10222729 PKB-mediated events 29516 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223655 Adrenaline signalling through Alpha-2 adrenergic receptor 25083 24174 24175 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 60423 116642 353307 25176 63997 65142 140944 498910 85333 65194 DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors 24318 29238 25195 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 96%10223383 Vitamin D (calciferol) metabolism 63865 24873 25573 80848 25279 29216 114700 499417 362827 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism 362275 294673 500961 316642 65196 365984 116740 117185 407765 363494 64442 114104 64445 303729 25524 25227 311013 316033 83537 303631 364901 289687 83505 81919 94338 315222 24800 365619 310326 63888 684536 58924 64828 362409 683713 307404 50555 312689 84431 300129 83626 310508 300757 301525 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-RNO-75105.1 Fatty acyl-CoA biosynthesis 24159 94340 117243 300783 680115 301120 84013 191576 117182 60581 65192 50671 246074 171410 171402 171400 359725 25288 361802 361895 498728 29411 309449 113976 54398 364134 114024 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 96%10223301 Energy dependent regulation of mTOR by LKB1-AMPK 310091 298514 362045 373545 64226 297960 290291 24855 24666 78975 60445 65248 303605 295357 64562 314621 26954 117044 501146 117043 56718 25520 360776 83803 308869 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-RNO-888590.1 GABA synthesis, release, reuptake and degradation 25558 83612 79213 84556 25012 116470 25531 24803 171163 24379 81632 24380 79130 24468 25716 50676 64832 79212 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%10223215 Neuropilin interactions with VEGF and VEGFR 25589 246331 81527 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-RNO-9845576.1 Glycosphingolipid transport 299488 288707 293485 363120 500132 313771 64310 29579 PROTEIN UBIQUITINATION%REACTOME%R-RNO-8852135.1 Protein ubiquitination 360471 680424 64460 81816 314432 29534 83477 64631 287927 363836 304832 64156 296368 100362554 360847 360748 117044 266712 297337 362412 308282 300837 295568 293561 500636 307029 50522 303478 100909445 361831 24829 292588 313216 192255 363064 25737 100912032 363445 293184 116718 498560 641452 689226 116725 81920 305581 361531 297593 312703 306945 305268 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%10224243 Acyl chain remodelling of PS 361686 311341 362434 316039 498741 296048 362039 85311 691905 29354 24913 29692 295631 298579 29526 29359 CELL-CELL COMMUNICATION%REACTOME%R-RNO-1500931.1 Cell-Cell communication 25528 81736 301334 24511 316369 363509 304109 54281 363875 155183 64563 315546 310695 100359836 305679 64465 297893 500569 310678 50646 302783 24829 24828 117056 100361294 685909 680615 361537 303175 25697 64627 306970 25507 64315 689820 57341 26955 81650 266758 314641 360652 29144 362279 25066 361866 498515 306945 81717 116479 293860 310174 192248 85489 83501 680498 84430 304297 308417 365877 688673 116549 25724 362973 81634 362850 117048 362332 316639 690795 313806 60371 192183 29364 360687 303068 25705 498281 301887 84407 170922 29181 307237 29460 497229 300445 300289 81918 293142 290270 361432 363058 25409 29606 24790 362650 78947 84006 309757 287772 29163 292766 29162 64156 293721 691517 29669 360882 29668 362040 83805 29425 100360846 29382 83712 117263 192275 25581 63879 29666 313048 100188932 303353 365388 686092 117262 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 300955 29676 29675 84353 50522 81827 83806 311078 24514 192255 100912032 81504 313474 292064 81679 25150 500870 50654 25751 311163 83502 25125 83427 24498 499537 360820 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-RNO-72202.1 Transport of Mature Transcript to Cytoplasm 298385 360726 361814 689116 360972 298075 295284 362819 313449 305714 361859 313308 361990 688288 294429 117045 315170 361542 288701 287830 291874 362281 113975 296219 292085 114612 295692 117021 362335 366016 58958 362557 303057 65274 494445 113929 89827 29667 297522 245922 81738 683983 362687 53372 25497 499974 687575 299256 362098 689890 304277 289582 259170 79227 681062 59087 690585 501621 690303 290519 287113 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins 114764 29564 117281 286993 114514 298850 83836 363198 300225 362548 304477 298594 170845 252902 501099 85252 287746 287598 307805 311191 29648 500545 290396 102555739 295661 65201 314212 681185 308443 296137 81531 317252 305270 83572 140734 681050 58945 684439 79115 363875 117273 64515 297176 312754 114592 360840 294429 287830 299147 292085 25515 64465 24669 64373 297522 303251 81738 303811 683983 83721 81822 315648 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 64303 363193 363028 309179 315164 24673 304951 287876 289150 361416 363174 81655 303037 363059 24672 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 306608 24946 29565 362191 295394 29243 266670 293418 25268 260320 25295 25227 81716 311013 303631 305470 362154 315222 24800 308976 100137086 365619 314300 310326 307503 54281 362409 307404 360665 26962 170818 302470 124323 29304 288923 310261 288617 287444 303755 498034 314644 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225357 Regulation of HMOX1 expression and activity 24451 311545 STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels 299714 24244 679906 499287 362053 79430 83810 315272 140933 79425 292168 192675 29465 66026 689991 29233 29232 308637 367318 25749 304315 171497 64156 266730 24768 294141 24767 689560 171143 312981 171384 295041 114246 58950 301111 311287 293735 59299 63866 89821 314401 293874 63882 297930 116469 25688 312896 50522 314847 24703 286920 83514 192255 497948 361586 364973 79123 100912032 308015 294329 246215 689103 362247 25122 25364 292597 60395 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224263 Transcriptional activation of mitochondrial biogenesis 306840 24399 24787 293615 361596 690675 25309 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME DATABASE ID RELEASE 96%10222779 Inhibition of TSC complex formation by AKT (PKB) 24185 60445 25233 29414 24855 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 96%10225239 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 114097 NUCLEOTIDE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleotide catabolism 116593 315219 81656 289801 311580 287368 65135 295620 312373 497811 290029 311422 361068 171047 100363253 361274 287406 305149 313574 117260 85260 298881 64467 309390 316077 613267 314312 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins 81639 299732 24296 24297 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%10222621 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 25750 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 96%10224973 PTK6 Regulates Cell Cycle 83571 58919 366275 94201 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex 366381 292588 297176 361389 293155 296368 360643 288671 290875 64515 305420 361831 UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA 499914 290842 292058 307639 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10223643 Beta-oxidation of very long chain fatty acids 363516 85239 291075 50681 64461 501072 65192 171142 79244 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%10224489 SUMO is conjugated to E1 (UBA2:SAE1) 308384 301442 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%10225053 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 25498 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10222275 SLC-mediated transport of organic anions 65200 83500 365398 170698 140915 295417 58978 84511 140860 363024 64201 259248 432363 362188 85426 24221 363103 65202 29509 25027 29743 89776 170943 289459 294255 114511 29735 266998 85254 25246 80878 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 96%10221969 Cellular responses to stimuli 79239 292737 315994 114495 501560 116554 50658 81736 25493 25242 64046 309361 85482 24511 192218 29302 296456 302935 304569 94165 363849 84017 117062 300711 498013 290232 297758 294917 365057 24440 500054 360504 307798 307861 64012 307480 27137 298203 114766 24697 24185 29753 291671 25233 266759 116456 25420 307997 293103 286899 362293 81800 500907 29156 288444 297994 29154 307133 29489 311427 366734 113906 293524 29734 690038 81655 29564 64862 24404 29414 252902 85252 171361 304798 66026 140734 58945 81745 25400 24245 24246 171140 116484 301252 84478 29560 24208 298576 140639 299027 54318 296302 299331 294429 287830 291874 362281 363026 113975 292085 295692 117021 84578 362335 361810 366016 58958 362557 65274 113929 297522 245922 294515 81738 362809 260321 683983 53372 25154 365755 25497 302711 499974 312947 24600 24186 363630 25506 54225 25081 299850 299121 58966 24786 29167 84428 294010 56611 500336 113894 297932 298103 289407 362802 368044 298451 299971 170667 24787 436582 297566 312488 117596 94170 116664 366545 25309 29702 690675 89842 24468 26195 24451 100362347 26198 24253 50551 304962 303878 25352 363138 24356 641452 85431 303185 292721 500843 94167 84485 305464 297998 81920 311545 64317 360497 362441 113919 362573 298376 690751 360969 294744 25261 300721 259233 171562 304410 304063 64371 24248 25026 25029 689415 117038 113898 84006 287772 292766 64525 64156 296368 29669 29668 66021 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 303393 290875 24708 192277 287984 65138 94198 83724 116685 29673 295052 29671 29445 29670 29677 83619 29676 117254 29675 50522 29338 305420 361831 366381 292588 81827 293155 79129 83806 311078 192255 114494 287280 304127 24874 361765 94194 100912032 360643 64199 308901 681024 25617 315648 79218 24627 81807 245986 60449 102555170 293508 294962 25521 502988 171335 25725 24679 83579 24672 680149 100188937 362045 54322 117281 58979 116590 24244 114117 24400 81666 81667 114490 29699 81662 84683 360229 305679 29597 303333 24842 79245 293615 24472 65028 654441 24890 310678 307151 302783 24829 24828 296732 25282 313038 298282 117056 309626 363014 685909 680615 310258 303175 303730 64627 306970 688386 315136 306945 252934 501403 311860 680498 365877 114483 690795 361940 117104 362485 59102 25164 83571 309757 24413 25747 494444 94201 291145 680522 83712 201097 292887 497991 684828 295357 24437 313048 26954 314638 303016 116643 117044 117043 56718 360776 308869 84027 310091 298514 64226 688041 25672 301555 297960 78975 85265 79462 25614 24963 24426 60460 50689 315189 316101 314322 64345 296648 29452 309295 54702 81771 308457 448830 117269 310131 29260 363855 25272 84351 24516 24565 289014 24360 116599 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224427 Scavenging by Class H Receptors 54225 24791 DECTIN-2 FAMILY%REACTOME%R-RNO-5621480.1 Dectin-2 family 29337 25150 362432 81515 25441 25155 450223 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224811 RAF activation 299147 25594 117281 58960 56011 24244 24669 24703 170851 24605 687346 24514 170577 293621 309168 24525 315648 64363 309548 83805 114486 363193 25400 25344 312754 24245 309179 24246 24673 24672 171140 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-RNO-480985.1 Synthesis of dolichyl-phosphate-glucose 299346 295051 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222101 Carnitine synthesis 170898 64040 64564 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-RNO-5654716.1 Downstream signaling of activated FGFR4 25444 54250 25622 29369 29368 170583 25513 170582 25738 24605 293621 170911 85385 66017 81504 29349 24525 313845 361388 170700 25317 314850 289625 60464 116499 25114 316213 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-RNO-195399.1 VEGF binds to VEGFR leading to receptor dimerization 89811 25589 360457 94203 83785 114110 114111 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 96%10224979 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 24185 192255 366275 64156 312477 50522 100912032 361617 500985 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance 25292 54225 680551 25081 80848 50522 294930 25073 192255 298296 100912032 81782 65046 64156 266732 140670 83800 306825 54241 116563 314459 300438 266770 58851 25728 WAX BIOSYNTHESIS%REACTOME%R-RNO-9640463.1 Wax biosynthesis 679520 302425 293173 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 96%10224369 Signaling by Hippo 305922 25402 65157 297387 56011 308265 29753 311622 299116 360920 292994 303251 363014 300289 65189 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-RNO-9954709.1 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 361923 134480579 117042 289508 287122 499782 140661 140662 29257 300079 292964 293418 81768 100361974 362631 360572 245981 497860 287772 81770 292766 64525 64156 29669 64640 29668 81764 29425 100360846 81765 81766 117263 81767 25581 81763 29666 303353 100361060 365388 58927 117262 85492 689284 287984 65138 94198 29283 29282 29673 296709 29671 64302 29670 64306 29677 29676 100360439 29675 64307 50522 361831 134486107 81827 83806 311078 192255 100912032 291434 641452 81729 25347 81807 28298 64205 26962 100910714 312199 64298 290641 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223949 Organic anion transport by SLC22 transporters 83500 365398 29509 89776 HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224391 Hyaluronan degradation 64152 24782 300993 404783 367166 24434 363103 500052 294673 300757 25406 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors 25029 58965 24241 58966 399475 116506 56820 24476 171519 25026 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190377.1 FGFR2b ligand binding and activation 499349 29348 25443 54250 25317 170579 25022 170633 64535 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 96%10224963 Signaling by PTK6 29560 498596 117268 170843 64015 50522 24697 362271 25414 296472 24605 192255 293621 29496 100912032 54245 59325 24525 24185 83571 306400 25433 25125 25313 25676 366275 64156 94201 64022 312477 363875 300160 117273 361617 432361 58919 24329 360820 89829 500985 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-RNO-9754119.1 Drug-mediated inhibition of CDK4 CDK6 activity 25193 64033 58919 114483 94201 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223231 PI3K AKT activation 25513 59109 310738 25467 29376 170911 85243 117273 CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-RNO-389359.1 CD28 dependent Vav1 pathway 25150 29431 64465 25408 29433 56822 29432 363875 313050 25660 81504 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223849 GP1b-IX-V activation signalling 25513 116727 25578 24703 691992 502858 25259 83805 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%10224527 HDMs demethylate histones 680498 682469 64627 298144 313539 103689969 689582 500569 360665 312440 310678 301128 266670 317432 684297 304495 317425 304809 363630 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223957 Postsynaptic nicotinic acetylcholine receptors 25753 25302 54240 25590 81721 65024 79557 25103 170945 29422 54239 171131 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 96%10224245 Acyl chain remodelling of PE 297694 293711 311341 288025 362434 498741 289733 296048 360426 362039 691905 314075 29354 24913 29692 295631 298579 29526 313997 29359 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 96%10222739 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 288525 363109 297393 294400 498272 291095 297417 310935 498486 299346 305291 360518 302972 81759 501167 25547 300741 311530 302915 300089 316642 116696 298071 117523 365984 303692 363103 25280 117185 304860 301155 291325 407765 363040 64442 64445 287920 29758 316033 114711 364901 83505 313139 25197 362924 313231 315212 300668 362031 362547 311204 81726 296394 298541 311847 502017 293587 29640 295051 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 96%10223165 Metabolism of steroid hormones 24470 682974 29632 305291 25146 64677 116700 24950 25329 84013 360348 117182 289456 25322 691018 79243 116463 299270 24800 25116 25117 291699 313786 24230 29189 29680 24192 25557 79122 296972 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 311860 290805 308755 497672 293452 64557 304719 83508 363924 299112 102551085 303194 315969 498119 499966 290997 64046 290631 316794 171366 171525 304573 85482 289777 287634 59102 192218 293489 298098 298534 287927 685055 310034 297561 25573 361815 64156 306734 305000 499417 362385 300711 299638 302982 690043 297627 316235 296099 360588 497856 302953 64012 499870 294800 293678 498265 498411 308669 295052 291787 289468 100361529 689055 50522 297486 140583 362827 24829 362704 192255 288003 114494 361698 25737 100912032 288414 289758 116468 59294 89809 303175 64627 116725 306945 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 96%10223325 WNT mediated activation of DVL 81650 58822 303251 116549 303811 309419 83721 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10225443 TGFBR3 regulates activin signaling 29200 29263 29610 24504 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224167 Downregulation of ERBB4 signaling 311567 297930 192255 64156 50522 100912032 25489 83805 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10224079 Growth hormone receptor signaling 89817 24391 24683 25235 24684 116590 50689 24514 24918 25126 81515 24697 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%10222603 FMO oxidises nucleophiles 84493 246245 25256 PTK6 ACTIVATES STAT3%REACTOME%R-RNO-8849474.1 PTK6 Activates STAT3 25125 366275 89829 PLC BETA MEDIATED EVENTS%REACTOME%R-RNO-112043.1 PLC beta mediated events 84420 116590 24244 170538 64508 81742 25050 81666 24681 29699 24680 81662 60341 29691 24654 83506 81636 25238 25031 293508 302950 85240 64532 25521 25289 25725 24679 29241 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol 171088 85238 365382 290651 316376 83523 116699 252899 282636 80849 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 96%10223561 Glycoprotein hormones 29200 64549 25447 116700 83711 25329 25653 24504 25196 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 96%10222231 IRS-related events triggered by IGF1R 25444 25443 54250 25622 29369 83504 29368 170583 25513 170582 25718 246273 29516 60662 170911 361992 84477 170579 25022 85243 66017 81504 29349 29348 84489 313845 25233 29376 81745 361388 363131 170700 25317 314850 289625 170633 24483 65052 60464 24482 25467 79114 116499 25114 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225365 Drug-mediated inhibition of MET activation 24553 24446 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope 304822 291759 292848 307562 291754 102546758 302934 24332 313672 310575 294094 60335 499345 308564 292949 682408 293619 408235 287925 291760 81679 689230 299587 295190 291755 309528 361319 307563 306871 REGULATION OF CDH11 FUNCTION%REACTOME%R-RNO-9762292.1 Regulation of CDH11 function 81679 303068 84407 311163 362850 300289 84353 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%10224011 N-glycan trimming in the ER and Calnexin Calreticulin cycle 29468 117263 29144 293719 361014 192255 116643 64156 64202 50522 100912032 298012 REGULATION OF TNFR1 SIGNALING%REACTOME%R-RNO-5357905.1 Regulation of TNFR1 signaling 24835 25625 50522 688466 81859 687813 60371 498803 361831 114210 364386 60383 309361 192255 360827 287155 266610 94193 100912032 115771 306886 246756 363836 641452 117279 83427 311401 308493 64156 362828 81920 309295 246294 100362554 64044 63879 246244 312937 299827 84351 290864 289014 DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER 306274 360471 362479 292778 84389 288651 288588 361580 366163 304719 497967 502227 245976 299112 294693 50522 83503 361365 690966 117017 291703 363633 498109 192255 289561 288003 361698 171525 304573 25737 302502 100912032 59102 288414 361181 289758 116468 59294 89809 246216 298098 64156 266713 362385 362394 314061 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%10222845 MAPK targets Nuclear events mediated by MAP kinases 117281 315648 81646 116590 315305 501560 50689 81647 116554 314322 300980 50658 81771 117269 363193 116663 60587 24673 25272 24516 289014 24672 PECAM1 INTERACTIONS%REACTOME%R-RNO-210990.1 PECAM1 interactions 116689 25150 29583 25738 296456 54259 25622 81515 313050 83805 29302 G2 PHASE%REACTOME%R-RNO-68911.1 G2 Phase 295052 114494 399489 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 96%10223307 MDK and PTN in ALK signaling 25613 24924 266802 81517 GLYCINE DEGRADATION%REACTOME%R-RNO-6783984.1 Glycine degradation 299201 360975 171133 298942 306586 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway 29582 RNA POLYMERASE I PROMOTER OPENING%REACTOME%R-RNO-73728.1 RNA Polymerase I Promoter Opening 680498 303175 365877 64627 50689 25574 306970 690795 310678 302783 24829 24828 117056 306945 685909 680615 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%10223407 Platelet Adhesion to exposed collagen 25150 684555 81515 25441 SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 362814 170538 498596 29414 64624 50522 24680 25513 24605 192255 293621 29496 170911 287155 100912032 85385 81504 59325 24525 24185 25150 117255 29340 313845 25233 25433 25313 361388 114562 298787 366275 64156 296121 64022 117273 83805 432361 24329 299331 84427 CHYLOMICRON REMODELING%REACTOME%R-RNO-8963901.1 Chylomicron remodeling 292697 54225 25080 140638 25081 300027 24539 25649 25728 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements 366017 170538 85252 294975 24680 679140 287772 292766 300045 64156 29669 29668 29425 100360846 117263 25581 171350 29666 303353 365388 117262 24468 85492 287984 65138 94198 307850 56011 29673 24472 29671 363854 29670 29677 29676 29675 50522 81827 79256 361109 83806 311078 79426 192255 29344 100912032 24185 307947 300944 25578 25379 289014 EPH-EPHRIN SIGNALING%REACTOME%R-RNO-2682334.1 EPH-Ephrin signaling 361882 84009 81732 289820 300802 29192 292788 295378 306636 287989 83709 686310 297518 316369 81751 114559 25676 312275 24338 25537 29433 304109 83841 360546 81515 363875 29491 117273 288669 366492 83805 289231 24408 24410 81687 81686 25615 360854 64465 81824 54227 293621 25614 25150 81822 316539 116683 310643 84358 79208 171287 29431 94268 298528 312279 501203 29210 287876 29432 PROSTANOID LIGAND RECEPTORS%REACTOME%R-RNO-391908.1 Prostanoid ligand receptors 292661 63889 309212 25637 84023 24816 24929 25652 498475 81752 SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223661 Serotonin receptors 24473 25324 29581 25187 65032 25689 29595 25323 25075 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 96%10222509 Response of endothelial cells to shear stress 311860 680149 117281 58979 24244 114117 24400 81666 25026 117104 81667 81736 29699 25493 25029 81662 309361 66026 24511 29302 296456 81745 58966 305679 29597 56718 64226 56611 24697 363014 64199 25614 24185 315648 79218 24627 24600 315189 245986 296648 60449 309295 29156 293508 29154 294962 310131 25521 25725 84351 24679 83579 24672 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-RNO-199992.1 trans-Golgi Network Vesicle Budding 24803 56084 192243 299825 83576 64630 54226 363476 140673 192152 116743 64678 312689 25151 83800 116561 85491 288785 54241 100362805 365191 366618 171575 83730 366311 313409 304344 24468 310746 361459 306332 25387 81803 641528 295217 81659 364183 317630 683687 287709 296199 25751 25306 361632 252929 89816 295171 29292 362609 689256 312694 294900 64310 289312 309451 25319 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 96%10224603 Asymmetric localization of PCP proteins 287984 65138 94198 64512 317674 29673 29671 29670 29677 29676 29675 50522 81827 303251 83806 311078 192255 100912032 100360552 266715 287772 292766 64156 690516 29669 64558 29668 29425 100360846 117263 25581 29666 303353 365388 117262 364754 85492 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%10224061 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 363520 309157 309361 116725 311245 84351 309295 305549 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases 64314 293625 300711 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures 498265 290805 308755 497672 293452 64557 291787 689055 102551085 303194 498119 499966 64046 85482 289777 287634 192218 293489 306734 305000 300711 302982 360588 497856 302953 64012 499870 293678 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223835 Organic cation transport 362403 54302 54301 29726 24904 310732 309131 50662 64037 29503 360539 29504 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-RNO-196836.1 Vitamin C (ascorbate) metabolism 309465 64001 24778 25035 50622 25551 50621 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription 246299 690254 685539 306012 304204 362537 306542 171068 83503 690966 301246 294687 498109 362095 117526 114205 316810 311487 310685 361102 685465 313914 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA IFNB signaling 288264 25622 24697 116689 312688 120103159 298205 502959 100361294 298210 24481 686326 120103158 100911527 690894 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223499 Rap1 signalling 171337 59326 361714 56011 25578 24703 54286 361710 295347 313644 29434 293508 SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%10222091 Signaling Pathways 360903 94203 83785 114110 114111 89811 25589 360457 25466 300177 301007 311721 307016 292756 304007 366492 304546 315686 171581 305645 140922 114612 140931 29497 29578 64200 500538 302855 117259 100360623 292994 24835 25625 81859 687813 498803 114210 364386 100910984 679566 303882 304758 500715 316226 366608 313438 171041 305987 114203 315992 313388 117550 171549 314906 140928 54248 81749 688705 445442 81743 29254 308875 29340 81678 305795 360606 64373 81821 140866 100361138 63885 24483 25692 24482 25666 60395 25679 497978 499913 301512 497932 309207 25262 79210 114031 363455 363009 81732 308761 304282 29146 287746 307562 500246 56785 64160 83809 259242 299857 289820 498174 308509 192348 309722 679934 293497 81531 305457 315265 116717 500287 192207 365355 305341 297518 360915 304815 685357 79115 84006 287772 315348 292766 297406 64156 295588 315121 29669 29579 29668 25097 288669 64515 306506 29425 312077 100360846 297176 306871 84031 117955 117263 300067 25581 114592 300186 29666 360849 54237 498331 313024 303353 365388 360840 303583 367235 117262 361813 85492 305605 117538 192277 117542 287984 65138 360854 303553 94198 287543 25515 310090 29673 116685 498547 360500 29671 29670 304530 303888 29677 29676 114004 81824 29675 116670 50522 310806 362938 303653 361831 81818 114116 58823 81827 313216 114243 54227 500929 83806 315732 311078 305938 63994 192255 362842 25230 287280 690130 361765 304813 100912032 291694 64199 310013 24654 60377 286924 315829 83506 300111 24611 362988 315648 302976 79218 291755 360616 291999 24627 311450 298144 24626 25306 25638 89816 81636 245986 362993 25238 246314 24668 312667 60449 311793 308021 25031 360596 293508 289229 302950 85240 64303 363193 299145 294962 309362 84014 64532 295635 25521 25686 678766 286928 24673 307035 25289 25643 261736 79249 25601 25725 317296 294568 24679 689997 83579 29241 367902 367901 24672 680149 292279 84420 688319 313934 117281 117039 58979 300838 116590 29745 140908 24244 310519 170538 113960 114117 306152 24400 83425 64508 84510 81742 501099 25050 25488 81666 308666 81667 306004 362271 24681 29699 682937 24680 81662 81664 60341 29691 29316 25369 25083 24175 29597 362859 25591 25622 297893 24890 310678 307151 302783 24829 24828 25193 313038 117056 309626 363014 685909 680615 310258 303175 303730 64627 60421 301164 306970 304794 361391 315136 311567 81650 290829 58919 306945 362093 102550344 501403 311860 680498 365877 116549 85471 50662 690795 294075 24504 25196 29200 59301 289874 94201 65248 56010 83712 291171 64562 313048 116643 25520 83803 84027 362891 373545 688041 301555 287643 294924 315093 78975 686412 66025 306792 298062 60399 500409 310812 116744 500526 306141 29415 29733 362950 307810 500317 361655 24605 289257 293621 305614 64159 306628 24586 314251 81504 25614 24525 25150 81646 313845 290905 308458 50689 298787 315189 81647 313558 314322 59265 294048 311245 296648 116723 309295 25660 81771 89812 294235 117269 25556 363520 24225 310131 64044 79209 25408 64545 313121 362491 361696 79240 56822 25730 25054 84351 24516 58918 365865 289014 140607 315994 315305 501560 116554 300980 308267 317546 25740 81736 362477 25493 308118 116663 54226 309361 60587 81809 24511 59086 59107 29302 292406 59106 292734 25717 296456 311061 83838 54281 29373 500245 362800 24855 360827 94193 79121 24185 60445 29753 25233 29748 100361818 366962 24674 24675 29448 84492 246294 84589 25532 29414 367915 363235 24264 81515 117273 83805 64053 24408 24410 25400 24245 24246 24412 83613 29495 25252 171140 117284 58948 81810 83823 29610 25387 25388 29591 116700 25329 313050 24703 24514 25627 24179 25605 60337 379044 25593 500157 310327 78964 25723 287102 80722 293897 295445 502097 114107 25704 171081 116689 25513 25326 25746 116562 366508 116630 170911 60664 84477 85243 85385 29376 361388 298947 24335 497931 294429 287830 292085 297522 81738 683983 498790 307092 291283 361266 171516 307096 364773 498789 191574 25506 292778 288588 316123 689116 83503 298075 361365 690966 117017 363633 498109 289561 287730 24816 24938 25107 25108 25229 688605 689936 316019 29385 246075 282832 116498 25340 554302 50672 25342 29141 60590 292409 58959 64042 53949 308408 25477 294394 246759 58965 29397 24260 58966 25111 292419 29151 24476 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25449 81753 29363 54258 84348 25321 24232 81752 24473 305236 50577 289023 171551 65032 24925 24807 24806 24808 24929 290493 292794 117549 24247 316259 295144 316137 192223 317219 25570 81503 24241 29256 498289 362505 366668 100360071 497196 100911796 497078 25542 24695 64019 64636 302619 81648 299242 117264 57305 81657 353250 308163 84007 24694 117027 57302 89810 100270683 360579 29581 171056 365228 306307 25555 314910 29238 114090 300078 89808 81644 689869 29595 81645 29237 192205 29235 192206 170634 316009 24221 29234 84475 29471 171044 24318 102552838 360918 294123 314386 171519 24797 294124 685243 24677 25524 25645 294121 114098 114099 29446 81672 25087 84023 399475 294807 25653 25652 24323 24326 81779 24448 81668 29335 301086 690158 367315 24418 24659 266997 24417 24419 24772 114105 24414 60628 24416 25504 24415 445269 309212 25187 83633 500091 171371 494319 497942 56813 117064 64680 498475 192648 192649 246358 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 56820 310444 25075 25195 29555 192646 501177 500089 100310876 301066 25726 113914 679957 287910 298006 116506 24875 29407 25040 78981 78980 171158 78983 362454 78985 498335 117041 25616 366270 24769 366274 29538 117029 245920 83518 24889 246219 266607 60669 25051 60665 29413 29412 78976 25298 679975 54305 85268 78979 302378 25706 25026 170926 259224 259222 25029 24613 25380 25264 296472 24174 690448 25024 60432 25265 361383 363682 29180 288995 378939 498791 691774 116677 29636 319107 64803 319105 24182 25033 29191 24180 287673 499194 113959 24717 25245 63843 25248 170704 117518 24953 25007 260319 680188 25360 58812 287561 287562 24604 63850 502757 171104 171108 500101 83567 24166 310869 29290 171101 58949 83828 83830 117526 25155 84396 114208 81522 24498 25344 25467 309179 116499 432361 60352 64030 24827 25114 63995 25597 114856 192126 25594 362045 58960 65142 363272 25444 25443 54250 81511 309399 192213 314612 29369 29368 24592 309153 315707 299617 170583 170582 24366 25454 24367 297682 170577 29496 309168 170579 25453 29372 66017 64511 29349 29348 84489 66023 65179 25433 25313 25676 25318 25317 314850 89807 312664 685269 170633 499929 361679 288924 24553 25523 25525 312754 79114 170668 313757 24329 293847 364052 305679 295347 114513 100909827 24446 316213 299147 246781 305203 56011 289080 29542 311406 360814 498596 305539 25514 24669 83504 29434 296072 310533 362572 498576 302808 314596 24888 60427 170851 687346 60662 100361294 25267 59322 25022 29622 25266 59325 171337 29183 24629 24628 64363 309548 304893 24716 361171 170700 361601 64022 289625 25136 170818 171109 114486 60464 364686 24188 100360427 83571 366275 680111 361178 292887 303605 295357 29304 81663 314621 26954 117044 501146 117043 117045 56718 360776 25639 308869 310091 298514 64226 116636 25435 297960 290291 24644 24666 83840 81922 288057 81921 24852 29431 171115 29432 360820 84357 361120 117277 25372 192218 301128 309816 140583 25613 59075 50678 308776 309962 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363028 25576 25578 315164 25577 304951 311331 289150 360658 303517 361416 363174 292770 361396 81655 303037 312574 307511 29135 50866 363059 114764 29564 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 113927 287598 307805 311191 29648 500545 102555739 295661 313017 65201 681185 308443 296137 317252 305270 83572 140734 681050 58822 58945 684439 81745 291678 304832 301965 161452 64558 120099577 79257 503000 501584 29382 498997 498233 691857 63879 103691373 291209 679110 65027 25565 295251 364754 289026 29417 312451 29134 24881 310704 64512 317674 300837 313589 312936 309419 308051 499918 299802 84353 679158 282581 290317 266772 500863 246768 360990 84424 303251 303412 364712 303811 293165 24205 140585 83721 140586 300673 313474 81679 311163 83502 83427 301252 246244 312937 299827 117268 170843 64015 59109 310738 25738 117255 83709 316369 114559 29433 363875 296849 311254 81527 25061 311764 362513 310688 29149 497941 246331 24705 500633 685072 685750 299331 81687 360420 81686 24919 170906 25682 58851 246332 363026 363425 266603 266686 64466 308190 25335 84578 361810 304157 289950 500569 298942 25149 81654 24172 81530 89813 362110 353252 294515 25718 362809 260321 117098 25154 170635 361597 365755 302711 500629 25522 313210 29563 313689 116676 83574 361967 297805 24600 312495 60349 298184 25098 170897 171068 140868 406162 83765 317598 450224 24596 360678 29409 54350 65134 64351 65165 503165 24506 24505 116666 24373 25125 287876 64535 499349 306618 66013 500608 113894 287537 64314 287418 64639 84009 120099896 310635 311647 310999 57027 78966 307398 117020 309653 301059 303634 301334 295449 300802 363460 293024 100362710 29192 362648 292788 295378 298404 25402 310460 307098 246174 117089 363509 81751 140898 361921 304109 310192 64547 687105 29491 289231 83800 116561 24392 54241 116563 315840 89829 500985 309175 58840 84482 64551 313838 64465 360635 289878 688297 363143 29481 25700 307401 363445 641452 25437 25270 81920 307170 406163 29480 54289 65183 54294 54293 54292 54297 54296 498246 301088 84583 100361166 365901 59293 84022 114705 246254 362021 289076 266715 56761 497961 140584 50664 65046 116743 140670 83724 363131 65052 29611 170921 116478 54245 366061 29528 312477 300160 311332 84010 309922 294981 310655 83537 94338 25507 314641 362279 81717 116479 293860 81634 316639 60371 315294 288666 362550 289883 287357 114850 316526 300289 81918 362065 303586 306782 84426 361846 100360552 114487 24790 691517 289711 289712 304729 296532 25273 84399 84380 289180 364475 89830 361769 691171 50938 690516 29499 140588 140589 301737 363616 297699 83837 79239 287155 266610 246097 25385 306886 64665 246756 363836 117279 114562 83764 100362554 65189 305922 65157 297387 308265 311622 299116 360920 24697 25414 29263 59326 361714 65205 29543 85253 311401 308493 362828 24924 266802 81517 25353 500485 290921 367100 81707 245921 25237 311598 29381 81507 85435 116510 289264 500873 25366 25378 66018 304591 313477 29650 499508 140590 79429 310914 315761 29530 59328 25320 302415 290864 24255 684097 50554 361749 50557 25631 688466 100360606 115771 310306 296121 500572 498798 81516 25671 29357 311030 29560 360471 24208 56084 25490 299236 499308 366205 299809 24918 25126 50646 94195 25023 297932 298103 246273 29516 29757 289407 361992 362802 368044 296981 298451 299971 83615 170667 436582 498416 297566 312488 117596 94170 116664 366545 360406 64678 170824 85428 116548 64624 60383 64630 306417 308968 66021 297930 362566 79129 296988 24874 300813 25489 362814 287156 192647 171086 497974 303743 287612 59320 65209 311324 499241 307724 361712 308577 100362124 305349 303968 295654 116475 312651 503018 362265 287942 29613 81737 365407 116547 300115 303501 100363276 296323 309696 297383 310833 306183 78967 312113 29275 314249 312108 83620 296060 308097 306357 360942 363031 688429 362456 361882 314618 305234 367085 300225 303611 314903 305367 54308 303222 498282 361940 60431 361029 171296 360509 291000 290396 503306 366170 299012 314212 29355 363213 293947 306279 246249 312640 29681 362893 679082 288093 307459 305156 306400 498130 310074 25537 296162 25096 310621 300030 313618 361617 100362346 117535 290669 362834 64520 310614 361724 300955 117063 81822 84427 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5685938.1 HDR through Single Strand Annealing (SSA) 290805 311860 308755 498411 497672 64557 291787 304719 100361529 363924 303194 315969 64046 288003 85482 59102 288414 192218 116468 685055 310034 297561 306734 305000 300711 297627 360588 497856 64012 499870 294800 VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction 292697 680149 54225 25080 25081 25592 24244 81644 24400 64511 25318 24539 691984 171517 24710 25703 24856 24717 25702 25680 192259 259274 116673 24771 299858 362558 300027 64047 317322 25236 296972 29216 25216 315644 25615 58920 314941 25056 55939 289878 688297 85259 291318 363143 29481 140936 499132 316218 353252 116556 299521 81760 307401 363071 317498 266761 301233 293049 314264 64370 24711 25539 266714 59077 79222 89826 313689 498790 307092 291283 361266 171516 307096 364773 498789 191574 302425 25649 83579 89810 25728 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%10224783 SHC-mediated cascade:FGFR3 29349 24525 84489 313845 25444 54250 25317 29369 29368 60464 170583 116499 24605 60662 293621 85385 66017 81504 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-RNO-9033500.1 TYSND1 cleaves peroxisomal proteins 365571 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%10222789 Transfer of LPS from LBP carrier to CD14 60350 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%10225385 Regulation of Expression and Function of Type II Classical Cadherins 81679 303068 24790 84407 311163 362850 300289 84353 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224993 MET activates PI3K AKT signaling 24553 25513 361388 170911 24446 81504 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-RNO-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 361925 301020 83833 292404 303518 293514 296732 361825 368001 287876 297867 361295 305589 361711 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%10223779 Post-transcriptional silencing by small RNAs 192178 308971 298533 303774 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225171 RHOG GTPase cycle 362456 305234 84009 311647 25488 308666 361940 307562 60431 362271 361029 117020 360509 25513 290396 299857 299012 308509 64351 309168 24511 305457 295378 308875 310460 503165 29528 306400 140898 310074 310192 25096 315121 292756 29579 687105 64678 29491 366492 116666 308869 64465 360500 366608 305987 315992 25437 29448 317598 360678 78967 307035 314249 312108 29432 65134 100360623 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-RNO-8853383.1 Lysosomal oligosaccharide catabolism 310864 361378 246136 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 96%10224253 Synthesis of CL 366196 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%10224575 HDACs deacetylate histones 680498 83618 365877 310614 361724 84578 297893 500569 310678 293668 314205 64646 24829 24828 502125 365755 302711 363481 680615 362981 303175 64627 360531 306970 290284 83712 497941 84481 102554884 100362346 313048 117535 362825 306945 290669 362834 64520 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%10223731 Reduction of cytosolic Ca++ levels 116601 140448 29715 25391 29693 24244 29600 29599 29598 140447 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%10223305 Signaling by BMP 85435 289264 25366 25378 29610 79210 499508 50554 140590 310914 29530 59328 361831 29263 363455 24504 29200 690516 81920 29373 500245 81516 25671 313757 500485 290921 367100 25237 81507 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223709 Adrenaline,noradrenaline inhibits insulin secretion 680149 58979 79218 114117 24400 245986 60449 81667 294962 25083 81664 64532 25686 24175 25289 83579 64199 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%10224703 BBSome-mediated cargo-targeting to cilium 29374 299246 25273 83567 362142 100910342 24818 299809 361930 288305 294864 365770 316102 295230 363760 171044 29885 113948 500832 315484 311456 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10222843 Activation of the AP-1 family of transcription factors 116590 50689 116554 81647 25272 314322 24516 50658 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 96%10222915 Signaling by TGFB family members 116590 54250 25490 300802 81809 287155 24511 29192 59086 292788 59107 29302 59106 292734 25717 296456 81751 311061 83838 54281 29373 500245 499929 289231 362800 313757 500985 25591 304758 79210 114031 500715 297893 29263 363455 362110 310655 65205 25522 363445 29543 81920 500485 290921 367100 81707 245921 116479 25237 29381 81507 116510 85435 289264 25366 25378 313477 499508 140590 310914 29530 59328 24504 25196 81918 100360427 29200 24790 64156 680111 117273 361178 25639 29417 81810 83823 29610 25387 25388 29591 50554 24666 24373 25631 50522 361831 192255 100912032 84396 114208 50689 690516 81516 25671 29357 297699 300813 83837 GABA SYNTHESIS%REACTOME%R-RNO-888568.1 GABA synthesis 24379 24380 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%10222319 Cytochrome P450 - arranged by substrate type 301517 83724 362782 499353 308190 288517 308445 24307 290623 266674 24894 24299 502969 298423 24886 24895 25426 25527 25242 313375 25243 286904 498999 24306 299566 503122 266761 54246 171178 50549 312495 25279 310848 114700 313786 29277 25429 29189 29680 171522 25086 79122 24296 24297 266682 25428 252931 60351 RAC2 GTPASE CYCLE%REACTOME%R-RNO-9013404.1 RAC2 GTPase cycle 287537 305234 306152 304282 311647 308666 361940 307562 60431 360509 25513 290396 308509 170911 679934 60664 24511 295378 83709 29528 307459 306400 310074 315348 304109 310192 315121 292756 29579 64678 25097 366492 66021 304546 116666 313024 308869 64465 304530 303653 58823 79129 63994 362842 366608 300111 315992 25437 29448 317598 309696 29431 360678 78967 286928 307035 79249 312108 29432 367902 SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies 314800 117099 24450 295458 25014 367112 65984 79238 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor 680149 58979 79218 301512 114117 24400 245986 60449 81666 81667 81662 294962 303634 24816 83579 64199 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%10222547 SMAC (DIABLO) binds to IAPs 64026 100360940 63879 REGULATION OF PYRUVATE METABOLISM%REACTOME%R-RNO-9861718.1 Regulation of pyruvate metabolism 83536 315949 497900 290705 289950 64156 298942 50522 296849 288731 311254 81654 81530 89813 364686 681913 192255 117098 246311 54705 100912032 24533 298982 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 96%10222111 Cellular response to chemical stress 100188937 79239 54322 292737 113894 298576 140639 84683 24787 25309 360229 690675 24440 360504 363026 84578 654441 296732 25282 365755 26195 302711 24451 26198 312947 50551 24185 303878 25352 25233 85431 94167 688386 84485 297998 24186 311545 64317 113919 298376 294744 259233 171562 25506 64371 252934 64862 29414 24404 24248 113898 84006 287772 292766 25747 64156 29669 29668 29425 66021 100360846 497991 117263 25581 29666 303353 24786 116643 365388 117262 85492 303393 84027 287984 65138 94198 83724 29673 301555 29671 29670 29445 29677 83619 29676 78975 29675 117254 50522 29338 81827 79129 83806 311078 192255 287280 361765 304127 94194 100912032 308901 681024 79462 24426 102555170 116484 84478 502988 171335 24565 24360 116599 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10223125 Membrane Trafficking 117106 84018 108348178 294324 361244 361120 296750 60668 117277 60422 317396 362118 60568 311854 60566 60564 500906 83576 363466 54226 25372 363476 79214 29216 64670 288700 307868 365793 292886 689102 64633 292760 311494 501854 315059 313234 24855 25183 29662 312257 362599 117103 299799 307039 363123 290746 499768 361987 294709 171452 361227 363326 306229 360827 287427 94193 24942 287709 79121 94197 361555 24185 60445 29753 25233 252916 84590 50645 287110 287624 367073 365372 313493 246324 29448 295333 207119 81830 246294 29489 81754 282834 79434 315668 364419 81756 680465 363720 29885 58974 361916 84589 308942 366896 81655 360956 309678 287873 360797 363059 266688 303734 246772 29564 300147 679886 288779 317580 64862 25532 25531 313340 29414 299075 316017 252902 311880 292074 114638 367915 315999 361697 362983 315756 84379 311911 25530 501550 85238 289350 360768 363235 691042 83572 140734 58945 64558 83805 50592 24255 25387 25388 300678 25710 24932 303251 313474 25751 252929 498798 85256 311030 292994 56084 25490 299825 25716 300158 316226 64516 361308 363288 297522 289168 171291 113886 293502 315740 85248 171041 313254 353302 294286 246209 303575 303659 314473 289309 117548 64154 117550 171549 289994 293456 64310 362162 314906 361073 309523 54350 289397 287276 309451 60355 65134 297428 290994 54225 300888 246117 79120 304290 54400 58842 363136 690252 171121 192243 299850 310411 24648 300743 64462 100912115 56042 252853 89868 140940 60384 290659 64351 65165 300674 291990 25423 685144 25108 299121 362237 306264 309010 140673 503165 246310 690961 361705 301012 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 304978 116666 117513 100360302 94189 29167 84428 79117 361207 252889 58817 93646 314030 295461 294010 361577 81803 24807 81645 24221 24825 29491 64678 83800 116561 85491 24392 54241 288785 100362805 79128 365191 140694 116563 366618 171575 315840 83730 366311 313409 304344 24468 394266 266707 310746 25655 361459 306332 266706 29585 500985 497913 29584 50563 84403 29586 79217 50564 363677 24803 81732 64630 289820 192348 116717 297518 360915 65046 64156 116743 24180 140670 288669 171574 84393 360854 81824 50522 192255 100912032 361632 25306 89816 25238 261736 24827 313934 117039 296649 500249 362283 100361513 29528 192152 25433 309798 65277 25313 64187 286932 293344 685079 25218 120097389 312689 25151 60562 364981 309922 117051 311919 24329 59325 29183 64022 314641 310839 641528 363273 363266 140932 24805 64189 363283 287645 65178 124461 687208 295217 297995 367308 81659 364183 317630 114590 114113 289257 292925 290635 305614 64159 298598 683687 290639 314251 292944 81504 360953 290775 287367 296199 266606 314349 81922 116692 308458 116691 681059 192154 310097 295171 81921 100359675 306809 29292 29704 362609 360426 64621 689256 312694 360202 362502 294900 289312 300438 117028 25319 84357 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%10224925 Regulation of the apoptosome activity 116590 100360940 63879 690675 50689 78963 295961 58918 25309 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-RNO-351906.1 Apoptotic cleavage of cell adhesion proteins 83497 25402 304822 306871 291755 83502 292994 84353 307562 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-RNO-9768919.1 NPAS4 regulates expression of target genes 266734 25242 84469 25243 29657 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 96%10225217 Biosynthesis of maresins 29277 171522 25086 24297 266682 252931 65030 25290 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%10222567 Coagulation pathway 171154 306608 24617 24946 25592 502858 315272 29436 29243 29366 24366 54226 295703 24367 360918 499099 25268 308637 260320 29302 362248 60327 116727 289055 25087 83580 691984 171517 691992 65051 314615 25259 685269 306761 302470 116673 24771 79224 304917 317322 25236 25216 25615 58920 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-RNO-1268020.1 Mitochondrial protein import 63868 360826 293991 498332 171374 307081 25611 NURD COMPLEX ASSEMBLY%REACTOME%R-RNO-9937850.1 NuRD complex assembly 680498 365877 310614 361724 297893 690795 310678 302783 24829 24828 117056 685909 680615 303511 303175 307362 305501 293038 64627 25573 100359714 50659 300389 306970 301442 291940 113984 406195 83712 303060 360804 100362346 313048 117535 306945 290669 362834 64520 TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10223999 Transport of fatty acids 296578 94106 680602 25239 311839 65039 291582 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 96%10223209 Degradation of beta-catenin by the destruction complex 117281 113927 287772 292766 64156 161452 29669 29668 79257 29425 100360846 501584 29382 117263 25581 312754 29666 103691373 303353 679110 365388 25565 117262 85492 84027 312451 287984 299147 65138 94198 29673 29671 29670 29677 29676 29675 84353 50522 100360606 81827 84424 83806 311078 192255 287280 24205 361765 100912032 315648 363193 309179 24673 81717 24672 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 96%10223621 Protein-protein interactions at synapses 310519 306152 29647 29548 29547 25466 116647 116724 29546 65040 171297 60391 286930 679668 685472 116681 78957 290467 117096 293645 317553 304733 300913 313052 308571 116508 140592 312855 116595 64665 302473 309557 309349 500219 306147 294380 59312 83764 360406 64053 24409 24408 24410 24418 24412 24411 29629 29628 29495 24414 50592 25252 58948 29613 25529 308495 688721 365222 140945 59317 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins 25290 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10222571 Extracellular matrix organization 64350 499271 298702 24617 25304 310683 25567 29139 25361 25464 29331 25592 83577 54250 313785 25393 25713 81008 54266 114122 170921 360647 116640 81682 302248 58968 24680 24366 24367 309684 24914 81809 293677 24511 83727 59086 59107 29302 25043 59106 85272 287899 292734 25717 296456 311061 290350 309380 313662 83838 54281 305253 315714 29373 685269 500245 29158 362800 252835 116673 85490 24771 315071 29569 353303 314981 81687 312115 303468 289081 81686 60379 298936 497892 25681 25216 29345 24907 304021 66027 25615 309816 288016 25600 64367 294279 299940 500364 25412 432360 25654 305941 362584 315979 307548 362715 114200 362285 25335 367313 84352 363158 290637 84032 363458 288583 365460 678743 65164 315174 66015 65205 170808 24291 83513 116694 57025 24691 29268 29543 25697 306260 685612 117061 85253 499285 304608 304802 63834 315388 29156 29155 29154 29153 25353 303000 683849 291848 304135 499431 300338 25246 81707 25403 116479 25406 25481 25506 24153 103690254 81613 116510 100169747 306404 300341 408218 117033 25724 362347 63849 29650 25052 29175 83685 83470 308476 362701 29364 303068 445442 308995 29583 679837 301012 554172 691517 360606 315509 306628 299606 50654 290905 25627 83502 619374 290257 114489 25118 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%10222081 Mitochondrial Fatty Acid Beta-Oxidation 25363 29470 619561 64304 140547 113965 117543 24158 314304 503049 361992 315973 50559 289125 687008 170465 25045 25287 171155 170670 293453 170570 26759 291939 100363074 29510 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling 25125 25622 310132 24498 313173 688622 29201 81680 290655 24514 25707 100361294 245983 289747 89829 500985 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-RNO-196843.1 Vitamin B2 (riboflavin) metabolism 362942 751787 25732 311536 85496 499328 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production 81736 301059 304859 310461 309452 293624 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%10224571 Degradation of AXIN 287984 29134 65138 94198 29673 29671 29670 29677 308051 29676 29675 50522 81827 83806 311078 192255 100912032 287772 292766 64156 29669 29668 79257 29425 100360846 117263 25581 29666 303353 365388 117262 85492 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-RNO-72649.1 Translation initiation complex formation 292762 682390 298700 25348 691947 362952 81775 81776 299872 81773 81774 293427 288599 303831 299027 54318 65136 691531 27139 296302 288516 294282 122799 29236 681429 117053 100362640 64156 161477 292148 100361756 29288 29287 29286 29285 299899 124323 140654 171350 29304 140655 29284 300069 293484 103689992 122772 117045 29258 83789 94266 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10224737 RHO GTPase cycle 79239 306618 66013 287537 287418 84009 120099896 310635 311647 310999 78966 117020 309653 303634 301334 363460 293024 100362710 24511 362648 295378 298404 83615 310460 307098 64665 246174 363509 140898 114562 361921 83764 304109 301007 311721 310192 307016 292756 687105 29491 304007 64678 366492 170824 304546 315686 24392 171581 54241 305645 140922 315840 309175 114612 313838 64465 363445 25437 25270 85428 29448 307170 65183 363009 304282 29146 287746 307562 500246 56785 64160 83809 29648 299857 64630 306417 498174 308509 192348 309722 363235 679934 293497 24264 305457 315265 116717 500287 192207 365355 305341 360915 308968 685357 315348 297406 295588 315121 29579 25097 117273 66021 306506 312077 306871 84031 117955 300067 300186 360849 302855 498331 313024 360840 303583 367235 361813 305605 192277 24255 117542 303553 287543 310090 116685 117259 498547 360500 304530 303888 362938 313050 303653 81818 114116 58823 313216 114243 79129 500929 315732 305938 63994 362842 25230 690130 291694 310013 315829 300111 81679 362988 302976 291755 291999 311450 25306 89816 362993 246314 81522 312667 498798 311793 308021 360596 289229 299145 301252 309362 29611 84014 295635 678766 286928 307035 261736 79249 317296 294568 689997 367902 311030 100360623 292279 688319 313934 117039 300838 29745 310519 113960 306152 83425 84510 56084 25488 308666 306004 362271 315707 682937 25513 170911 309168 60664 116478 83709 29528 316369 114559 29433 314850 363875 299331 362859 114513 316213 299809 50646 366608 313438 365407 305987 315992 304893 300115 303501 100363276 317598 296323 309696 297383 310833 360678 306183 313388 78967 362279 312113 29275 314249 312108 83620 54350 296060 308097 306357 65134 360942 363031 688429 362456 361882 314618 305234 367085 300225 81634 303611 314903 305367 54308 316639 303222 498282 361940 60431 361029 171296 360509 291000 290396 503306 366170 299012 64351 314212 29355 363213 293947 306279 246249 308875 312640 29681 362893 679082 288093 503165 307459 305156 306400 498130 310074 25537 296162 25096 310621 300030 313618 361617 116666 116643 308869 301555 300955 64373 305614 64159 81504 81822 313845 24852 29431 171115 287876 29432 84427 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 96%10225459 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 680498 303175 365877 64627 689883 306970 690795 310678 680155 302783 24829 24828 366975 117056 306945 685909 680615 290270 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9037629.1 Lewis blood group biosynthesis 366064 296564 84597 288161 58924 407765 363040 64445 MITOTIC G2-G2 M PHASES%REACTOME%R-RNO-453274.1 Mitotic G2-G2 M phases 25594 117281 406168 692032 303024 64158 311573 309098 311802 311529 290626 300963 315423 171566 362203 683722 29479 363055 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 316531 296554 287929 310344 680991 314787 60347 246150 29214 299331 500069 362980 29213 81740 192228 307347 305882 311546 24842 117103 29753 300126 266713 246294 29489 363174 307511 114764 83836 84389 399489 85252 299850 287101 117104 64462 311191 682033 308937 83572 58822 58945 287772 292766 64156 29669 171102 29668 56010 29425 100360846 117263 25581 29666 54237 303353 365388 29167 117262 85492 287984 65138 94198 294010 361907 25515 29673 295052 29671 29670 29677 29676 29675 50522 116670 81827 85265 25203 83806 311078 192255 114494 361643 287280 361088 361765 308768 304813 100912032 306102 689296 171103 316602 361613 315648 301252 24673 24679 24672 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-RNO-399954.1 Sema3A PAK dependent Axon repulsion 25150 29433 363875 312213 246331 301252 29431 309280 299331 361597 29432 29751 289392 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222605 Activation of NOXA and translocation to mitochondria 492821 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 96%10222077 Citric acid cycle (TCA cycle) 293615 299201 360975 298942 81829 288740 361596 290985 79250 114597 25014 287069 298596 362323 157074 170587 310378 24368 499125 102550385 363061 289217 114096 361726 94173 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223521 Netrin-1 signaling 25614 25150 64465 300955 60629 310192 315615 25311 171119 299737 363875 83805 54319 PKR-MEDIATED SIGNALING%REACTOME%R-RNO-9833482.1 PKR-mediated signaling 117281 24472 114495 300955 295704 362678 117063 314172 54287 691105 84472 304859 63880 309361 499155 298693 81635 291978 29219 25498 24963 501552 315648 502320 60460 303742 25125 170897 309295 312754 24673 54237 311130 311430 24468 363006 84351 24672 24842 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222945 Alternative complement activation 24232 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%10223567 Enzymatic degradation of Dopamine by monoamine oxidase 24267 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%10224781 SHC-mediated cascade:FGFR1 29349 24525 313845 25444 25443 54250 25317 170700 83504 29368 170633 170583 79114 116499 24605 60662 293621 170579 85385 66017 81504 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 301517 498790 83724 307092 192242 291283 361266 171516 307096 364773 498789 25429 191574 25428 246211 60351 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly 113975 685068 499391 292085 295692 84404 117021 362335 687711 363462 366016 58958 65160 691231 362557 65274 113929 100362099 64301 297522 245922 681031 81738 362688 683983 53372 316108 25497 310769 499974 84473 312947 171365 680737 294429 291794 287830 291874 362281 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%10222823 Toll Like Receptor 9 (TLR9) Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 501570 100912032 315648 81646 312562 50689 25742 363131 81647 116725 314322 311245 309452 309295 81771 293624 310877 65052 117269 448830 500133 364867 363193 363520 363328 291921 60350 64044 29260 300447 313121 24673 362491 287707 363855 25272 84351 246280 24516 289014 305549 24672 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes 114764 117281 83836 299850 64462 311191 64158 311573 311802 311529 290626 300963 315423 83572 683722 29479 58822 363055 58945 305467 366403 367153 360672 308064 252921 293844 100362495 56010 316531 296554 310344 314787 60347 246150 29214 54237 299331 500069 29167 29213 81740 192228 307347 305882 294010 25515 29753 29489 24679 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 25444 54250 25622 29369 29368 170583 25513 25738 24605 60662 293621 170911 85385 66017 81504 29349 24525 84489 313845 361388 25317 314850 60464 116499 316213 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade 680149 24244 289878 688297 85259 291318 363143 29481 140936 499132 316218 116556 299521 81760 307401 317498 301233 64370 25539 59077 79222 64511 25318 24717 259274 83579 TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling 24835 25625 308267 50522 688466 81859 687813 57027 60371 317546 498803 361831 114210 364386 60383 309361 192255 360827 287155 266610 94193 100912032 115771 306886 83537 246756 94338 363836 641452 117279 83427 311401 308493 64156 362828 81920 309295 246294 100362554 64044 63879 246244 312937 313121 299827 84351 290864 289014 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%10223737 cGMP effects 25523 140928 171115 29691 54286 63885 81743 308899 25262 191569 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%10225399 Regulation of Expression and Function of Type I Classical Cadherins 85489 680498 84430 365877 688673 116549 690795 25705 300445 293142 290270 29606 78947 309757 287772 292766 64156 293721 54281 29669 29668 362040 83805 29425 100360846 83712 29382 117263 192275 25581 29666 313048 100188932 303353 365388 305679 117262 686092 85492 287984 313648 65138 94198 688041 29673 29671 29670 64701 29677 297893 29676 500569 29675 84353 50522 310678 302783 24829 24828 81827 83806 311078 192255 117056 685909 100912032 680615 313474 292064 81679 25150 500870 303175 50654 25751 25697 311163 64627 83502 83427 306970 25507 689820 81650 266758 314641 29144 306945 81717 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) 117281 315648 81646 116590 314910 315305 114090 501560 50689 501099 300980 81771 117269 363193 116663 60587 24673 117535 289014 24672 PROTEASOME ASSEMBLY%REACTOME%R-RNO-9907900.1 Proteasome assembly 287984 65138 94198 29673 29671 29670 29677 29676 29675 81827 83806 311078 287772 292766 29669 116722 29668 100361517 29425 83499 100360846 288455 296651 117263 25581 29666 303353 365388 24968 117262 24967 85492 291983 29614 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-RNO-163358.1 PKA-mediated phosphorylation of key metabolic factors 171078 MITOPHAGY%REACTOME%R-RNO-5205647.1 Mitophagy 113894 64862 116549 685620 363254 308416 50522 365601 288731 300075 83529 83532 83531 299514 363442 192255 266601 362245 360827 192647 361321 100912032 56816 298575 363836 641452 64156 116725 81920 83805 246294 81650 299827 304017 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 96%10222489 Glucagon signaling in metabolic regulation 29699 24953 25521 25725 24679 293508 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223807 SLC-mediated bile acid transport 85426 289459 85254 295417 294255 363024 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%10222225 Insulin receptor recycling 83615 170667 436582 297566 312488 117596 94170 24506 116664 24505 366545 360406 24697 25700 297932 298103 29757 289407 362802 368044 296981 298451 299971 METABOLISM OF STEROIDS%REACTOME%R-RNO-8957322.1 Metabolism of steroids 24470 682974 29632 305291 25146 64677 24950 84013 360348 117182 25573 25279 114700 499417 296972 89842 29216 170698 80848 58978 289456 25322 691018 79243 362827 116463 291211 293688 29637 25675 81726 619549 25541 298298 81727 29540 29230 308100 309262 63865 117278 498790 114100 310645 83791 64191 299270 81681 24800 140910 307092 78968 25116 25117 300095 291283 89784 79244 361266 29580 171516 24186 307096 364773 498789 191574 24192 29725 84509 301024 65192 24917 291699 313786 24230 24873 25429 29680 362360 25557 79122 298369 502348 24777 259221 25428 296461 79111 25440 311129 246211 60351 303497 301517 303879 83569 83724 362782 309527 300790 140668 192242 116700 25329 29189 INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling 84388 373540 301365 29197 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%10225301 Activation of RAC1 downstream of NMDARs 171503 83506 60341 24244 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-RNO-73856.1 RNA Polymerase II Transcription Termination 365407 171365 314417 680737 299811 116697 304277 366468 289582 683927 681062 687711 689116 298075 100362099 681031 291877 311670 501688 311166 299256 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223173 Glucocorticoid biosynthesis 24470 682974 29632 25146 299270 25116 360348 25117 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%10222503 PKA-mediated phosphorylation of CREB 84420 24244 81636 64508 293508 29699 302950 64532 25521 25289 25725 24679 29241 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225415 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 311860 306030 680498 83724 299607 365877 287475 140908 303403 299180 84578 317343 690795 310678 316209 302783 24829 24828 85265 290939 299905 679693 117056 365755 302711 685909 680615 303175 64627 309757 306970 497991 497941 25664 619436 83516 291567 300367 293500 306945 24708 THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome 116484 29665 301252 290408 287362 300732 117514 282817 315435 58923 G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation 680149 58979 79218 114117 24400 245986 60449 81666 81667 81662 294962 25601 83579 64199 GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation 116649 680149 84420 50599 58979 29713 83633 29712 29718 114117 116560 24400 64508 81667 81664 64199 286924 24611 79218 81636 245986 60449 302950 294962 64532 25686 81657 25289 25643 83579 25743 29241 170847 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225451 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 311860 306030 680498 83724 299607 365877 287475 140908 303403 299180 84578 317343 690795 310678 316209 302783 24829 24828 85265 290939 299905 679693 117056 365755 302711 685909 680615 303175 64627 309757 306970 497991 497941 25664 619436 83516 291567 300367 306945 24708 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 363516 50681 498728 83512 501072 84575 309449 171400 79244 25541 25288 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10225031 Activation of the TFAP2 (AP-2) family of transcription factors 64466 299810 313596 114491 114490 CA-DEPENDENT EVENTS%REACTOME%R-RNO-111996.1 Ca-dependent events 83506 84420 116590 24244 170538 81636 64508 25238 81742 25050 24681 293508 29699 302950 24680 64532 60341 25521 29691 25289 25725 24679 29241 CALCINEURIN ACTIVATES NFAT%REACTOME%R-RNO-2025928.1 Calcineurin activates NFAT 29748 100361818 24244 24674 24675 361400 25639 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%10222539 Activation, translocation and oligomerization of BAX 64625 APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10222195 Apoptosis 304822 116590 305884 170538 64639 116554 292994 307562 60371 83497 313017 266610 24917 246097 171378 25385 492821 25402 140734 306886 298534 246756 64026 58945 100360940 246142 117279 25318 25311 64547 116502 287606 25309 498072 56010 291145 680522 64625 171528 201097 306871 259274 84359 361092 24170 684828 114114 296654 24437 317589 63879 690675 78963 295961 56011 316164 116685 367786 84353 81818 24888 171116 298282 24205 64159 25614 29753 291755 29748 83502 50689 353316 448830 364867 25576 363328 25578 60350 64044 29260 25577 58918 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%10223681 Signal amplification 286924 680149 58979 79218 64803 301512 114117 24400 245986 60449 81666 83805 81667 81662 294962 81664 303634 25686 25643 24816 25265 83579 64199 IRS-MEDIATED SIGNALLING%REACTOME%R-RNO-112399.1 IRS-mediated signalling 25444 25443 54250 25622 29369 83504 29368 170583 25513 170582 246273 29516 60662 170911 361992 84477 170579 25022 85243 66017 81504 29349 29348 84489 313845 25233 29376 81745 361388 363131 170700 25317 314850 289625 170633 65052 60464 25467 79114 116499 25114 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-9013700.1 NOTCH4 Activation and Transmission of Signal to the Nucleus 25578 406162 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%10223283 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 117516 25008 84349 360640 362788 500910 171369 361795 498666 360548 60371 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%10224933 Regulation of PTEN localization 360471 63879 192255 64156 50557 50522 100912032 25489 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 96%10223459 Synthesis of 5-eicosatetraenoic acids 114097 296851 312086 25290 84024 29624 DEGRADATION OF CDH1%REACTOME%R-RNO-9766229.1 Degradation of CDH1 287984 65138 94198 29673 29671 29670 29677 29676 29675 84353 50522 81827 83806 311078 192255 100912032 313474 292064 81679 500870 25150 50654 25697 25751 311163 83502 83427 287772 292766 64156 29669 29668 83805 29425 100360846 117263 25581 29666 303353 365388 117262 85492 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222595 Activation of BAD and translocation to mitochondria 29753 25576 56011 25578 29748 313017 25577 64639 171378 56010 ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors 25645 25083 29413 29412 24925 24174 24175 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223085 Digestion and absorption 25552 497039 25711 25656 289032 113901 25702 25680 65197 432367 64055 117554 50682 84028 363465 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%10222765 Glucagon-type ligand receptors 680149 25051 24166 58979 79218 29446 114117 24400 245986 24875 117064 60449 25040 25321 81667 81779 294962 24953 24769 25024 60432 83579 64199 29555 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME%R-RNO-9840309.1 Glycosphingolipid biosynthesis 364901 362275 83505 81919 63888 58924 64828 683713 50555 300129 83626 310508 65196 365984 116740 407765 64442 64445 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-RNO-8849471.1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 25414 24525 306400 24605 25676 366275 293621 363875 360820 54245 117273 362271 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-RNO-73776.1 RNA Polymerase II Promoter Escape 292778 84389 288651 288588 361580 316123 502227 291773 294693 317256 83503 83828 170844 361365 81673 690966 83830 171152 117017 309638 288533 373541 291703 293345 363633 294018 498109 289561 303918 117526 287571 266713 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-RNO-9841922.1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 311860 306030 680498 83724 299607 365877 287475 140908 303403 299180 84578 317343 690795 310678 316209 302783 24829 24828 85265 290939 299905 679693 117056 365755 302711 685909 680615 303175 64627 309757 306970 497991 497941 25664 619436 83516 291567 300367 306945 24708 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225327 Drug-mediated inhibition of ERBB2 signaling 114562 299331 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 96%10222525 E2F mediated regulation of DNA replication 117281 85241 315648 682033 24673 301323 24708 24672 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-RNO-432047.1 Passive transport by Aquaporins 25293 367316 25386 25240 65054 25480 25241 29172 286758 29171 65133 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%10225539 CHD1 and CHD2 subfamily 680498 365877 300837 192246 687711 81785 305479 690795 310678 302783 24829 100362099 24828 287768 245957 681031 299620 292019 295270 117056 363064 313583 685909 291295 680615 171365 680737 303175 293184 290614 64627 308738 304832 84401 306970 100361269 81781 680891 303607 361531 306945 291794 84486 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-RNO-500753.1 Pyrimidine biosynthesis 24240 288051 65156 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222515 Cam-PDE 1 activation 29691 24244 81742 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-RNO-6781823.1 Formation of TC-NER Pre-Incision Complex 306274 360471 117039 362479 292778 84389 288651 288588 363273 361580 366163 497967 502227 245976 363283 294693 50522 83503 361365 690966 117017 291703 363633 498109 192255 289561 302502 100912032 361181 287367 246216 360915 64156 266713 362394 314061 261736 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%10222617 Clearance of seratonin 29539 25553 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 96%10223427 Miscellaneous substrates 288517 308445 310848 24307 290623 266674 298423 171522 286904 24306 299566 266682 503122 252931 50549 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224807 TNFs bind their physiological receptors 25069 683163 25341 89814 353218 302424 25625 498666 252878 156767 117516 25008 500592 500590 365581 296872 25572 498769 HYDROLYSIS OF LPE%REACTOME DATABASE ID RELEASE 96%10224237 Hydrolysis of LPE NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%10224683 NIK-->noncanonical NF-kB signaling 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 117553 81827 309361 83806 311078 360640 303024 192255 287280 361765 100912032 287772 292766 64156 29669 29668 309452 29425 100360846 117263 25581 29666 303353 365388 117262 85492 SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%10222917 Signaling by NODAL 294515 116590 29357 50689 50554 25631 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME%R-RNO-9954716.1 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 315769 361923 134480579 117042 287122 499782 140661 140662 29257 498402 25348 300079 292964 81775 293418 81776 81773 81768 81774 100361974 362631 65136 691531 27139 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 81767 140654 81763 29304 140655 29284 100361060 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 361831 134486107 83789 192255 100912032 291434 641452 81729 25347 28298 64205 81920 26962 94266 100910714 64298 287119 290641 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-RNO-162699.1 Synthesis of dolichyl-phosphate mannose 296394 502017 29640 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 96%10225465 Maturation of TCA enzymes and regulation of TCA cycle 293615 361596 290985 79250 25014 298596 362323 157074 499125 102550385 363061 289217 361726 288740 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%10224465 TRIF-mediated programmed cell death 306886 448830 364867 363328 246240 64044 60350 29260 266610 DNA DAMAGE BYPASS%REACTOME%R-RNO-73893.1 DNA Damage Bypass 362412 81816 295704 289508 299112 50522 316344 292101 313702 140639 309812 192255 298693 288003 361698 171525 304573 25737 363164 302502 100912032 59102 288414 361181 289758 116468 59294 89809 298098 307905 64156 362385 84478 300795 100147704 316235 313387 116643 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling 29349 24525 84489 313845 25444 54250 25622 25317 314850 29369 29368 60464 170583 116499 24605 60662 293621 66017 81504 316213 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 96%10222209 Activation of the phototransduction cascade 680149 307401 24400 289878 688297 85259 24717 363143 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224343 Activated NOTCH1 Transmits Signal to the Nucleus 311567 304591 192255 64156 50522 100912032 CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction 140448 140729 24244 25650 24239 25262 116601 25391 25390 29599 29600 29598 81678 64672 24211 24212 24213 294141 29693 25400 689560 63847 24245 312981 24246 246150 63848 171138 362013 64119 25470 29248 114593 58950 63883 116695 681190 58971 56817 308405 367302 117018 64190 140728 116831 116564 84020 59299 140727 29639 65023 171140 116649 364241 29132 259243 83535 361618 25560 65180 89821 156873 65199 29712 24603 24602 289596 65195 276720 84429 59324 170899 688996 116489 445371 65272 116491 29715 113902 24598 64120 24590 116600 50688 300992 25679 140725 140447 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis 311860 116590 170538 81732 308666 362271 682937 25513 259242 25738 289820 170911 679934 85243 54245 295378 29340 297518 315348 25096 81515 363875 25097 288669 83805 29337 65261 309014 361527 299331 313024 117538 117542 360854 64465 300955 310178 81824 300678 25017 58823 54227 79113 100360919 25155 295279 81504 25734 25614 289211 25150 81822 50689 301252 360426 29431 286928 287876 79249 294568 367901 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 96%10222389 Activation of PKB 25233 246273 81745 361992 THE NLRP1 INFLAMMASOME%REACTOME%R-RNO-844455.1 The NLRP1 inflammasome 360557 24888 CDC42 GTPASE CYCLE%REACTOME%R-RNO-9013148.1 CDC42 GTPase cycle 306618 688429 66013 362456 314618 287537 367085 287418 314903 305367 311647 303222 498282 78966 361029 117020 309653 25513 303634 301334 299012 64351 363460 362648 306279 246249 295378 500287 362893 310460 288093 246174 307459 305156 363509 306400 498130 140898 310074 361921 304109 310192 687105 29491 361617 360840 303583 114513 64465 360500 305938 63994 362842 313438 291694 317598 296323 309696 309362 310833 360678 84014 306183 313388 312113 314249 312108 308097 306357 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-RNO-8866652.1 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 363445 360471 363836 498560 641452 81816 689226 64156 296368 314432 50522 303478 100909445 361831 100362554 292588 297593 360847 64631 192255 100912032 305268 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10223007 Plasma lipoprotein assembly 292697 25292 54225 680551 310900 25080 25081 303796 83470 293508 287276 25649 25506 24153 25728 313210 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223095 Heme biosynthesis 65155 289219 691853 309391 309070 304024 25374 361338 312382 24186 25748 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225349 RND1 GTPase cycle 65183 498547 84510 310999 25513 299012 116478 315829 192207 365355 306400 304893 310074 25306 83764 301007 362993 314850 312667 64678 366492 289229 306871 305645 140922 360849 302855 498331 84427 367235 305605 192277 316213 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 96%10222563 Response to elevated platelet cytosolic Ca2+ 24617 25023 24795 114095 24791 24244 311795 25651 84491 83785 307396 114111 24681 89811 24680 360457 246328 24366 54226 299909 24367 360918 81809 170924 59086 29302 63836 25524 60327 25717 25313 293676 294643 25087 24189 363104 113947 24825 685269 25373 364206 316531 305679 24446 246358 25266 24628 84590 85253 24186 24936 293860 309609 24153 360942 116510 24944 25081 305021 56782 81634 361196 54249 363015 24648 500152 100359512 498299 445442 686539 29583 363195 302470 307986 24786 116635 54404 312159 360950 140656 296488 24614 81803 81804 29186 24854 245955 315989 304983 295703 81814 116662 140594 309186 681544 293628 50693 682967 293886 24483 24482 94168 289316 287876 304805 308291 25673 NEDDYLATION%REACTOME DATABASE ID RELEASE 96%10224847 Neddylation 29560 117039 306129 366854 298576 313101 25490 500587 140639 303024 302502 361181 100909827 89829 303878 641452 304794 81920 64041 293060 361187 192351 362093 353227 305351 301674 363284 500017 64624 500262 308999 362902 362081 310363 313743 360860 362511 498959 100360914 503446 308283 304920 360915 293023 287772 292766 64525 64156 287706 494223 29669 29668 499114 29425 100360846 171043 83712 288921 117263 688993 25581 313722 29666 367785 303353 116643 305792 365388 292757 117262 85492 290692 287984 65138 361219 94198 498005 360818 294790 361907 687364 315723 29673 301555 29671 363273 685860 29670 309453 29677 305895 83619 29676 310324 29675 307200 363283 50522 363259 303602 309035 361831 314457 316131 100362121 313020 81827 362566 84607 311633 499016 306750 83806 245974 311078 315405 499807 192255 363790 498559 313242 287280 24874 361765 316228 362762 100912032 688478 315745 29168 303336 302288 287367 317381 364050 311881 360928 117152 688913 494320 300950 498560 500616 81807 117537 64345 361268 316614 29452 303792 300724 300849 117524 84478 297592 261736 316628 291339 313445 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222153 Nucleotide biosynthesis 288051 65156 24240 301005 287420 295088 81643 288259 362329 684425 315150 117544 289276 140946 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223721 P2Y receptors 171108 63843 691774 317219 117264 64803 767613 25265 29597 310444 302378 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450604.1 KSRP (KHSRP) binds and destabilizes mRNA 679140 24185 307850 25578 366017 300045 294975 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%10222537 Activation and oligomerization of BAK protein 64625 116502 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10222409 L1CAM interactions 58960 116590 116549 170851 289257 305614 64159 24511 116690 24586 314251 29302 25751 296456 83510 308458 29423 50689 65046 116743 83841 25416 140670 363875 685269 81521 83805 50687 171574 83800 84393 54319 81650 246331 54241 364686 140694 29431 79114 116563 24329 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis 313786 29189 360826 79122 102550385 290985 288740 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%10223757 Nectin Necl trans heterodimerization 363058 498281 308417 25066 360882 192183 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 96%10224227 Assembly of collagen fibrils and other multimeric structures 294279 25412 25654 300341 25335 83470 84032 365460 678743 24914 306628 50654 25697 290905 301012 290350 309380 554172 315714 85490 29569 81687 60379 25681 304021 HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation 288923 310261 287444 314644 SIGNALING BY NTRK3 (TRKC)%REACTOME%R-RNO-9034015.1 Signaling by NTRK3 (TRKC) 25738 29613 81737 83805 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224183 Voltage gated Potassium channels 27150 65180 65195 25736 246153 83588 307234 29738 25468 246325 116745 25327 25469 294065 295360 114032 117023 171011 65198 66022 365241 170739 24520 58981 296395 25470 259273 116695 29737 60326 117018 171146 84020 29731 307900 684516 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling 25125 25622 24918 25126 100911249 362629 362628 500836 25326 681112 444986 24514 685840 100361294 304091 170819 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%10222529 Cytochrome c-mediated apoptotic response 25402 64026 116590 100360940 63879 690675 50689 78963 295961 58918 25309 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-6782315.1 tRNA modification in the nucleus and cytosol 361201 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%10222581 Elevation of cytosolic Ca2+ levels 29665 25041 114115 29659 25505 81739 60395 25679 25262 81678 113995 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex 304758 300837 362479 292778 303281 84389 288651 288588 500715 361580 683469 316123 303132 81785 689116 502227 114510 294693 83503 311796 298075 361365 301119 690966 362110 117017 305455 679203 291705 291703 363633 498109 289561 363064 306261 293184 304832 81807 64525 266713 361531 266787 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%10223749 Regulation of actin dynamics for phagocytic cup formation 117542 311860 360854 116590 64465 300955 310178 81732 81824 300678 308666 362271 25017 682937 58823 259242 54227 289820 679934 100360919 54245 295378 25155 295279 81504 25614 289211 81822 297518 50689 315348 363875 288669 301252 65261 29431 286928 299331 287876 313024 79249 294568 117538 367901 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 96%10224133 Signaling by ERBB4 297930 498596 24918 24890 50522 25513 24605 300802 192255 293621 29496 170911 29192 363014 100912032 292788 85385 81504 59325 24525 313845 25433 81751 25313 64156 64022 83805 289231 311567 432361 24329 25489 RET SIGNALING%REACTOME%R-RNO-8853659.1 RET signaling 286908 361364 502694 498898 25622 362572 24680 25513 25738 25454 366508 170911 60664 84477 25453 85243 85385 81504 498416 66023 313845 29376 59312 24716 361388 314850 312477 313644 25136 83805 293508 25525 84427 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-RNO-429958.1 mRNA decay by 3' to 5' exoribonuclease 679140 360629 266605 307850 366017 293408 300045 363064 294595 294975 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-RNO-427975.1 Proton oligopeptide cotransporters 246239 246280 117261 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%10222531 Apoptotic factor-mediated response 25402 64026 116590 100360940 50689 353316 116502 287606 25309 63879 690675 78963 295961 58918 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10225119 Post-translational protein phosphorylation 116510 83501 54225 25081 24484 29650 114122 116640 84491 29237 24648 361029 170583 54226 24367 25268 300445 83727 59107 192152 25087 24825 691517 25373 683007 292485 24259 296290 83476 140638 79224 308807 303635 288038 289525 63878 25236 116635 680692 313954 89842 304334 362859 25685 362182 29417 25615 25285 171154 24765 689404 367252 79210 25307 303743 114031 29461 503164 24233 406161 25434 361676 25277 24232 84595 363455 360622 315111 338474 63880 286906 298683 79110 298296 60333 292905 29160 56646 25376 362862 24186 24498 25353 94168 304917 25649 25506 25728 HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors 24448 170704 85268 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%10222149 Formation of a pool of free 40S subunits 361923 134480579 117042 287122 499782 140661 292762 140662 682390 29257 298700 25348 691947 300079 362952 292964 81775 293418 81776 299872 81773 81768 81774 293427 100361974 362631 65136 691531 27139 288516 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 292148 64640 100361756 29288 81764 29287 29286 81765 29285 81766 299899 124323 81767 140654 81763 29304 140655 29284 300069 100361060 293484 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 83789 291434 81729 25347 28298 64205 26962 94266 100910714 64298 290641 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%10225425 MITF-M-dependent gene expression 25094 690660 50645 360034 361604 297893 161452 84353 25017 312451 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 96%10224203 TWIK-related alkaline pH activated K+ channel (TALK) 688996 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225441 TGFBR3 regulates FGF2 signaling 83823 29610 54250 ONCOGENE INDUCED SENESCENCE%REACTOME%R-RNO-2559585.1 Oncogene Induced Senescence 25164 116590 24356 50689 292721 114483 64156 494444 94201 50522 304798 192255 25261 100912032 304063 24842 MRNA 3'-END PROCESSING%REACTOME%R-RNO-72187.1 mRNA 3'-end processing 25594 500538 292778 361814 288588 316123 689116 83503 298075 361365 690966 117017 245957 363633 498109 289561 686980 80846 313583 361859 290614 308968 64156 100361269 303607 302855 290666 64510 291794 361542 288701 84486 292729 363005 361788 500242 192246 117259 308650 687711 305479 50522 140931 302969 494445 300996 100362099 29667 287768 79256 304859 29497 681031 299620 292019 295270 192255 362687 366693 291877 319110 311670 100912032 291295 687575 117280 311166 305586 299256 117282 171365 365407 680737 314417 299811 116697 689890 362361 304277 289582 683927 307474 29578 84401 81781 24668 313030 680891 313035 64200 499314 362152 361808 317612 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 297893 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%10223181 Axonal growth stimulation 24596 310738 360678 117273 ER-PHAGOSOME PATHWAY%REACTOME%R-RNO-1236974.1 ER-Phagosome pathway 365527 29673 29671 29670 29676 680842 64630 414786 24750 29468 29528 24223 24974 29669 29668 499400 100360846 24988 29666 83730 24968 24967 85492 291983 29614 CALMODULIN INDUCED EVENTS%REACTOME%R-RNO-111933.1 Calmodulin induced events 83506 84420 24244 170538 81636 64508 25238 81742 25050 24681 293508 29699 302950 24680 64532 60341 25521 29691 25289 25725 24679 29241 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 96%10223191 NRAGE signals death through JNK 306618 66013 500608 287537 287418 64639 84009 116554 120099896 310635 311647 310999 78966 307398 117020 309653 303634 301334 295449 363460 293024 100362710 362648 295378 298404 310460 307098 246174 313845 363509 114559 140898 361921 304109 310192 64547 687105 363875 29491 317598 114513 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism 363285 25331 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin 305343 304218 290577 313304 290668 63996 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-RNO-140534.1 Ligand-dependent caspase activation 306886 448830 364867 246756 363328 64044 60350 117279 29260 266610 246097 25385 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222011 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 24638 24640 54283 117276 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-RNO-1606322.1 ZBP1(DAI) mediated induction of type I IFNs 81736 25493 301059 304859 309361 292892 287707 84351 309452 309295 RHOF GTPASE CYCLE%REACTOME%R-RNO-9035034.1 RHOF GTPase cycle 116685 81634 83425 304282 64160 25513 64630 290396 503306 299012 362842 25230 690130 310013 29528 685357 310074 307016 246314 29579 29448 170824 117955 306183 78967 287876 360840 317296 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%10223933 Activation of kainate receptors upon glutamate binding 58948 553106 24244 298521 24407 24406 54257 29559 29495 25252 MRNA POLYADENYLATION%REACTOME%R-RNO-9770562.1 mRNA Polyadenylation 25594 500538 292778 361814 288588 316123 689116 83503 298075 361365 690966 117017 245957 363633 498109 289561 686980 80846 313583 361859 290614 308968 64156 100361269 303607 302855 290666 64510 291794 361542 288701 84486 292729 363005 361788 500242 192246 117259 308650 687711 305479 50522 140931 302969 494445 300996 100362099 29667 287768 79256 304859 29497 681031 299620 292019 295270 192255 362687 366693 291877 319110 311670 100912032 291295 687575 117280 311166 305586 299256 117282 171365 365407 680737 314417 299811 116697 689890 362361 304277 289582 683927 307474 29578 84401 81781 24668 313030 680891 313035 64200 499314 362152 361808 317612 SELECTIVE AUTOPHAGY%REACTOME%R-RNO-9663891.1 Selective autophagy 24255 29564 113894 64862 116549 303554 685620 363254 252902 308416 50522 365601 288731 300075 83529 83532 83531 299514 363442 192255 266601 362245 360827 192647 361321 100912032 56816 298575 140734 58945 363836 641452 64156 116725 81920 83805 300711 246294 29489 81650 312703 117287 299827 304017 81655 304579 SYNTHESIS OF DNA%REACTOME%R-RNO-69239.1 Synthesis of DNA 295596 299112 312538 292058 307639 499914 316273 290842 296178 313479 362485 291927 360621 304573 59102 29728 298098 292071 301430 288532 287772 292766 313138 64156 296368 29669 29668 362385 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 287984 65138 94198 84490 294790 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 311078 192255 288003 114494 287280 361698 25737 301323 100912032 288414 360643 289758 116468 59294 89809 85241 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%10222677 Immune System 24434 363247 25466 64046 117022 24493 300177 361677 303604 314870 60582 116690 287927 301442 499069 296654 309014 361527 24440 308669 25019 682457 498951 25613 81802 287610 29197 287624 29489 25578 81655 314336 50866 29564 500538 252902 313017 140734 58945 81745 317676 361929 306600 311396 84353 294329 81679 50654 25751 117152 300732 117514 282817 315435 58923 116484 29665 301252 360557 290408 287362 246244 312937 299827 292892 311430 246280 100360623 294673 292073 24835 25625 299825 691149 493810 362077 25738 171106 29692 100913063 362046 499356 308501 311783 296541 84388 499744 373540 29433 83841 301365 363875 84497 296554 314787 29214 299331 81687 361810 306998 316226 89817 361308 294515 289168 293502 315740 85248 171041 361537 24600 312562 353302 170897 140868 314473 117550 171549 64310 314906 81613 24159 140914 24944 54249 100911249 299850 315272 25325 24648 362629 362628 29364 500836 310132 313173 688622 29201 81680 681112 444986 685840 25707 245983 304091 289747 25423 170819 685144 299121 308875 308995 29583 29340 291085 54286 690945 81678 306761 114023 29337 287275 25407 292844 25505 24934 29684 25518 679787 29167 25110 498888 84428 89843 78963 140656 58817 93646 295461 294010 24614 81803 81804 56611 362638 29186 24479 301229 81635 25599 25084 681544 287287 362862 116553 293130 25125 500616 24598 314615 25441 287876 25679 25528 24795 113894 301512 64314 84491 81683 497932 301059 24931 24930 365542 309684 498079 294273 499099 498287 287818 29192 353253 304349 25262 295378 689853 364049 684529 25402 474146 290644 684984 287531 361704 24984 361710 100361633 297596 25109 293618 689004 313644 25373 292843 289231 83800 292846 292485 25424 296290 307199 54241 361673 288244 140694 100910497 116563 680844 300649 362443 312711 305081 574531 89829 367562 500985 64035 81675 64465 362029 25307 432363 641452 94167 81920 298689 24599 58857 64537 116470 24803 81732 24248 259242 289820 501072 65192 679934 24917 24375 297518 287772 315348 292766 65046 116743 64156 296368 29669 140670 25097 29668 288669 64515 171574 29425 100360846 84393 306871 361389 117263 25581 29666 54237 259221 313024 303353 365388 117262 100361814 85492 688730 288671 29143 290875 117538 304284 363127 287984 117542 65138 56780 360854 259275 94198 294790 500361 445415 499157 29673 58970 29671 690906 29670 317335 306324 155012 29677 290923 29676 24233 406161 81824 29675 100125364 64459 64185 50522 303180 298566 305420 24854 308632 497195 361831 24237 29687 291091 366381 81641 58823 292588 365466 29205 81827 114091 362634 474169 360914 54227 25419 306760 295703 83806 65197 64023 287721 311078 64668 54243 192255 498128 498234 79126 64681 117512 287280 690130 361765 29333 84397 84398 312705 100912032 299606 304692 360643 291854 192262 299928 290409 304543 289395 192177 303861 85274 25739 315648 302495 291755 140665 360618 500324 298792 363131 684322 298682 266775 304988 288778 58826 303542 293508 192264 65052 291948 363193 24257 24251 292537 304966 29714 286928 83462 24673 362966 311130 361635 79249 291339 293753 294568 363006 292666 25328 84586 367901 288174 24672 295706 304822 499271 25455 117281 302890 450222 116590 360445 24244 25308 289318 170538 361422 291759 64527 314843 100364984 690263 308666 298066 315916 362271 682937 89824 79130 362432 362431 363522 313837 300857 25046 29142 29521 361378 59313 378947 170923 54245 246272 83799 83781 362249 246250 311821 29528 363463 113940 29738 25374 310864 309649 25035 366988 25551 25151 25425 293154 81506 362859 83578 24842 315085 25622 29565 310678 315606 302783 24829 24391 24828 24683 25235 24684 291359 246116 117056 501570 64202 685909 363494 305355 680615 25227 303175 25697 64627 315222 24618 296321 306970 499925 304794 499926 641632 641636 84431 641651 641650 24620 311567 246238 81650 24941 299567 171162 641644 29144 290829 84355 685161 58919 25066 100361909 310611 361866 316519 306945 641652 641655 362093 84387 641657 641656 498659 311860 641658 680498 498658 301034 308417 316010 365877 116549 286995 613220 613223 613224 286958 29175 613225 296354 641627 690795 311558 313806 60371 50585 83687 305842 170496 641624 308873 290856 316241 83477 307366 305584 316033 289874 94201 290783 50692 65248 362040 56010 116967 300772 83712 290823 192275 407784 64562 313048 100188932 116643 309304 290638 686092 301626 25520 83803 84027 313648 362891 373545 688041 363160 301555 499342 287643 64701 690315 78975 360967 25017 24605 293621 64159 81504 25614 24525 25150 81646 313845 50689 25742 81647 315189 116725 314322 690516 294048 311245 296648 309452 309295 293624 25660 81771 287545 310877 448830 117269 364867 500133 25556 363520 252961 363328 291921 310131 64044 79209 60350 29260 300447 25408 313121 64545 362788 362491 287707 56822 363855 25272 84351 24516 58918 289014 305549 79239 116667 298702 315599 315994 500900 309157 25361 25464 315305 114495 501560 313785 25713 116596 54266 116554 502902 362418 360647 64171 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 502852 60587 498011 303024 287155 266610 24511 56816 306886 246240 296456 363836 299314 54281 24856 25216 450223 29662 307039 24697 59326 361714 306956 302934 306957 684480 288375 497811 688621 287427 287709 94197 24185 24691 407756 25233 29543 29748 25316 100361818 50645 366962 363577 499285 24674 25047 24675 361400 246324 29448 305311 84492 29153 246294 683849 307833 25406 24153 103690254 288779 25531 362347 63849 29414 29650 25052 367915 171361 361697 84379 317553 25095 290029 310461 292072 81515 117273 83805 25400 83782 24245 24246 171140 117284 140593 310178 361749 50557 295338 294269 363024 300678 313050 24981 25300 25710 24986 24932 360697 24703 116465 25712 24514 114558 113936 252929 302526 290257 24590 304987 304017 24968 24967 291983 29614 25704 171081 65038 116689 25513 25326 25746 116562 309147 366508 116630 54259 170911 60664 84477 85243 85385 25012 680127 29376 298947 288305 497931 299732 25290 361618 89821 299809 24918 25126 365769 690369 116558 25670 50646 297522 359726 120103159 298205 502959 298210 24481 686326 120103158 100911527 690894 305896 288264 63865 684440 361689 287276 25506 54225 29511 29385 292409 29221 54258 24232 94195 81503 25103 24699 310727 64019 499537 308163 84007 25023 301005 297932 298103 246273 362329 29757 289407 361992 362802 368044 296981 298451 299971 25524 170667 436582 498416 297566 312488 117596 25087 94170 116664 366545 85491 100362805 690158 83730 293118 58940 300250 24468 306332 445269 246358 311373 24812 293060 362277 361187 687633 315608 50558 192351 360534 316395 317241 362294 315863 29274 305268 140939 303963 295252 316005 353227 314613 313525 305351 301674 303735 295704 363284 500017 64624 299197 498726 500262 117553 140941 308999 60383 64630 306417 289437 64631 680609 155812 290655 84405 64517 362081 171334 171333 361383 310363 313743 689932 365368 362511 155140 498959 100360914 503446 29468 308283 499415 302987 288596 304920 308968 293023 24223 64525 287706 494223 685029 362087 113959 499114 66021 171043 619577 288921 688993 65261 313722 309591 367785 363188 305792 292757 360926 301515 316575 290692 683077 282845 312647 361219 498005 360818 361907 687364 297930 58949 302938 685860 309453 690769 171136 500532 680842 303478 100909445 306505 94196 500511 362566 79129 414786 306750 303689 296988 363790 24750 24874 79113 652955 100360919 311866 308901 25155 25617 295279 25734 303336 313264 289211 297961 311881 301042 362900 300950 291597 689226 81807 117537 24974 361268 316614 303792 499400 300724 306825 300849 24498 117524 25467 300968 24988 309179 313115 297592 60352 362367 316628 499877 300813 364681 25489 313445 192256 365527 362045 362377 362376 309758 362814 306129 366854 367167 81816 81511 289508 313101 501546 314432 81815 171105 296161 315707 500587 24366 361467 24367 25741 64511 292804 25060 24189 25318 312754 24191 305679 295347 24642 100909827 299147 56011 24472 29434 24888 287942 100361294 171337 361171 295214 116547 353316 317468 310553 305354 498840 25069 314618 683163 305234 25341 89814 353218 302424 500910 171369 361795 498666 360548 252878 156767 117516 25008 360509 84349 291000 500592 500590 365581 296872 360640 25572 498769 29681 362893 315949 25096 310968 56718 25639 308869 64226 289032 300955 362678 64189 117063 314172 362050 24667 54287 306231 691105 84472 171164 304859 63880 499155 81746 298693 304266 306204 304545 291978 24649 29219 25498 24963 24426 501552 81822 502320 60460 303742 171341 29292 360426 29431 29432 25319 24206 24464 84357 ATTENUATION PHASE%REACTOME%R-RNO-3371568.1 Attenuation phase 24963 301252 79245 60460 24472 362809 260321 299331 286899 24468 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223539 Proton-coupled monocarboxylate transport 65200 25246 114511 29735 25027 80878 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 96%10224917 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 25533 58983 24942 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 96%10222321 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 24297 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1963640.1 GRB2 events in ERBB2 signaling 24525 313845 25433 24605 432361 498596 293621 64022 59325 81504 DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions 315615 171119 TRANSLESION SYNTHESIS BY REV1%REACTOME%R-RNO-110312.1 Translesion synthesis by REV1 89809 64156 50522 316344 313702 309812 192255 288003 25737 100912032 288414 59102 116468 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-RNO-110331.1 Cleavage of the damaged purine 303175 365877 64627 306970 690795 302783 24829 24828 290232 297758 81528 170841 500054 306945 307798 307861 685909 680615 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-RNO-6806667.1 Metabolism of fat-soluble vitamins 292697 314941 54225 25056 55939 25080 25081 25592 498790 307092 24539 691984 171517 291283 24710 361266 25703 171516 24856 25702 307096 25680 364773 192259 498789 116673 313706 191574 24771 25571 299858 399684 362558 309004 300027 64047 317322 25236 296972 29216 25216 25649 315644 25615 25728 58920 ASPIRIN ADME%REACTOME%R-RNO-9749641.1 Aspirin ADME 140668 140860 63867 498940 25027 113992 89776 113902 266685 501907 286954 286989 24186 29277 171522 25086 293779 353317 266682 246263 688536 252931 25246 361637 24861 25303 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins 171337 25614 313845 24366 24367 295347 685269 83805 29302 81504 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%10224943 PI5P Regulates TP53 Acetylation 89812 290744 114495 364298 116723 140607 24842 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 81736 25493 301059 304859 309361 287707 84351 309452 309295 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-RNO-9027307.1 Biosynthesis of maresin-like SPMs 29277 171522 25086 24297 266682 252931 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta 315599 25742 64156 50522 309452 309295 293624 81736 25493 301252 54226 309361 246244 299331 312937 192255 299827 292892 287707 304017 311430 100912032 84351 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%10222019 Phase II - Conjugation of compounds 83783 171072 292915 499689 63867 290681 116632 116631 113992 24297 246232 83472 25331 290401 64352 408206 116568 295037 291394 81869 25260 360994 494499 25283 29566 29487 681913 156275 297029 362196 24421 24423 24422 25458 29739 24424 24426 309465 494500 266685 116684 501907 286954 501110 58962 303953 78959 286989 171341 683630 81522 171347 690050 29443 24267 140925 290947 24902 293779 24912 353317 300983 64473 246263 688536 64305 361637 288617 24861 297433 360268 361510 503103 58953 312952 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-RNO-9032500.1 Activated NTRK2 signals through FYN 25150 24225 315992 25054 363875 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 96%10225319 Cellular response to starvation 310091 298514 362045 64226 297960 297522 297932 298103 289407 362802 368044 100362347 298451 299971 170667 436582 297566 363138 312488 117596 94170 303185 116664 500843 366545 305464 360497 362441 362573 295357 690751 360969 26954 502988 117044 117043 56718 304410 360776 308869 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-RNO-1614558.1 Degradation of cysteine and homocysteine 367181 83586 170943 25274 192172 309732 24962 292710 81805 25256 81718 691966 79462 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-RNO-6814122.1 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 29374 116549 24818 299809 297406 288305 24400 54296 294864 60449 81667 295230 29481 81650 294962 64013 363658 83579 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 96%10225521 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 81679 50654 25697 64465 311163 83502 304109 64156 316639 84353 50522 363875 83805 301334 192255 100912032 REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction 498265 292767 366174 680264 362960 689349 100910102 680912 500052 290989 362623 499152 100362588 289777 24936 499870 24163 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222809 Lectin pathway of complement activation 114091 64023 64668 64459 299928 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 96%10224345 Signaling by NOTCH1 311567 304591 192255 64156 50522 100912032 NTRK2 ACTIVATES RAC1%REACTOME%R-RNO-9032759.1 NTRK2 activates RAC1 25150 24225 315992 25054 363875 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%10222651 Polo-like kinase mediated events 25515 308937 287101 307511 FRUCTOSE BIOSYNTHESIS%REACTOME%R-RNO-5652227.1 Fructose biosynthesis 24192 24788 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME DATABASE ID RELEASE 96%10222109 Detoxification of Reactive Oxygen Species 24404 117254 24248 29338 79129 79462 50551 24426 24787 25352 113898 85431 94167 84485 297998 25309 64317 66021 116484 113919 298376 294744 690675 24786 259233 171562 25506 64371 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation 288779 317580 299156 25532 310632 25531 171058 360571 305853 500088 171122 100364984 503269 81755 85237 367915 171111 367242 65158 689377 84379 25530 500249 309649 58983 288700 365793 689102 64633 25533 501854 117103 299799 307039 363123 24942 287709 94197 252916 140665 84590 50645 246324 29448 81830 81754 79434 315668 81756 84589 50866 266688 FRS2-MEDIATED ACTIVATION%REACTOME%R-RNO-170968.1 Frs2-mediated activation 114486 58960 59109 56011 310738 116590 170851 50689 287942 314850 295347 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 96%10222343 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 171155 25363 170670 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 96%10222721 Metabolism of vitamin K 313706 399684 309004 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9948299.1 Ribosome-associated quality control 289508 83789 291434 641452 81729 25347 28298 64205 81920 26962 94266 100910714 312199 64298 287119 290641 315769 361923 294754 134480579 117042 287122 499782 140661 140662 29257 498402 25348 300079 292964 81775 293418 81776 81773 81768 81774 100361974 65136 362631 691531 27139 294282 360572 122799 245981 29236 681429 497860 117053 287772 81770 292766 100362640 64525 64156 161477 29669 64640 100361756 29668 29288 81764 29287 29425 29286 100360846 81765 29285 81766 124323 140654 117263 81767 25581 81763 29304 140655 29666 293408 29284 303353 100361060 365388 103689992 58927 122772 29258 117262 85492 689284 287984 65138 94198 29283 29282 29673 296709 29671 64302 29670 64306 29677 29676 100360439 29675 64307 50522 361831 134486107 81827 83806 311078 192255 100912032 81807 OAS ANTIVIRAL RESPONSE%REACTOME%R-RNO-8983711.1 OAS antiviral response 306231 359726 304545 CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence 680498 315994 365877 116590 114495 501560 114483 116554 690795 50658 64046 362485 304798 85482 192218 25164 83571 302935 304569 94165 363849 64156 494444 84017 94201 296368 117062 300711 291145 680522 83712 201097 361389 684828 24437 290232 313048 297758 294917 365057 500054 307798 307861 64012 288671 290875 24708 24842 688041 116685 295052 50522 310678 307151 305420 361831 302783 366381 24829 292588 24828 293155 313038 192255 117056 114494 309626 685909 100912032 680615 360643 24253 310258 303175 303730 24356 64627 50689 292721 306970 314322 315136 81771 116484 117269 25261 306945 363855 25272 24516 304063 363630 289014 501403 FLT3 SIGNALING%REACTOME%R-RNO-9607240.1 FLT3 Signaling 24525 24185 498416 313845 25233 29414 25513 294515 24605 293621 170911 84477 81504 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation 292845 24244 29565 171361 83789 302931 102553119 689197 89820 361664 299521 316976 24468 CHAHP COMPLEX ASSEMBLY%REACTOME%R-RNO-9940465.1 ChAHP complex assembly 297093 117535 360609 64622 DAP12 SIGNALING%REACTOME%R-RNO-2424491.1 DAP12 signaling 24525 25150 313845 366962 24223 81511 363875 313050 29337 25513 25738 24934 24605 29684 293621 25110 170911 85243 85385 295378 25155 361537 81504 367901 KINESINS%REACTOME DATABASE ID RELEASE 96%10224083 Kinesins 300158 316226 361308 363288 289168 171291 113886 293502 315740 85248 171041 313254 353302 294286 287624 246209 303575 303659 84393 314473 289309 117548 117550 171549 314906 309523 289397 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%10223385 Regulation of thyroid hormone activity 25430 65162 29475 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%10222825 Toll Like Receptor 7 8 (TLR7 8) Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 501570 100912032 315648 81646 50689 25742 81647 116725 314322 317468 311245 309452 309295 81771 293624 310877 117269 448830 500133 364867 363193 363520 363328 291921 60350 64044 29260 300447 313121 24673 362491 287707 363855 25272 84351 246280 24516 289014 305549 24672 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-RNO-430039.1 mRNA decay by 5' to 3' exoribonuclease 361736 361109 500988 500305 297455 364624 361399 498934 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223099 FGFR1 ligand binding and activation 29349 83823 29610 25444 25443 54250 25317 170700 83504 29368 170633 170583 79114 116499 60662 170579 66017 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%10222849 Toll Like Receptor 3 (TLR3) Cascade 315599 315994 117281 500900 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 293624 310877 117269 500133 363193 363520 291921 64044 313121 24673 362491 292892 287707 363855 25272 84351 24516 289014 24672 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%10222821 MyD88 dependent cascade initiated on endosome 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 293624 310877 117269 448830 500133 364867 363193 363520 363328 291921 60350 64044 29260 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs 25594 680498 56011 83724 365877 24208 114004 500569 116670 690795 64373 310678 302783 24829 24828 313017 117056 29355 304813 685909 680615 303175 29753 64627 81745 298144 306970 363875 117273 56010 25576 25578 25577 306945 307511 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%10222163 Nucleotide salvage 25095 290029 362015 192357 79127 24165 117533 24465 25028 25368 315219 297389 362638 289801 292072 311864 295620 291585 304944 291824 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 96%10222831 Toll Like Receptor 2 (TLR2) Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 680127 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%10223507 Chemokine receptors bind chemokines 171056 60665 171371 89808 497942 29363 54258 84348 246358 305236 84475 171551 116637 360918 363682 685243 688605 316019 29385 282832 301066 81503 298006 362505 287673 25542 117518 246759 301086 498335 29397 308163 287561 29538 24772 287562 117029 114105 117027 245920 60628 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME DATABASE ID RELEASE 96%10222631 Amplification of signal from the kinetochores 114764 29564 117281 286993 114514 298850 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 317252 305270 83572 140734 681050 58945 684439 64515 297176 312754 114592 294429 287830 299147 292085 25515 24669 297522 81738 683983 315648 306464 679342 287624 291441 257649 257644 64041 25448 94266 29489 363193 363028 309179 315164 24673 304951 289150 361416 363174 81655 303037 363059 24672 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%10223589 ATF6 (ATF6-alpha) activates chaperones 304962 89842 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%10222507 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 680149 64226 58979 24244 114117 24400 81666 25026 81667 29699 25029 81662 66026 64199 24185 79218 24600 81745 315189 245986 296648 60449 29156 293508 29154 294962 310131 25521 58966 305679 25725 29597 24679 56718 83579 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%10221963 DNA Damage Telomere Stress Induced Senescence 365877 116685 295052 690795 302783 24829 24828 64046 362485 114494 85482 685909 680615 192218 303175 83571 64627 302935 304569 94165 363849 84017 306970 117062 300711 291145 680522 201097 684828 24437 290232 297758 500054 307798 306945 307861 64012 24708 24842 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 96%10222911 TGF-beta receptor signaling activates SMADs 81810 29610 313477 29591 50554 25631 50522 25490 192255 81809 287155 24511 100912032 59086 59107 29302 59106 292734 25717 296456 311061 64156 83838 54281 81516 362800 29357 297699 83837 25639 500985 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-RNO-69601.1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 113927 140583 81827 83806 311078 303024 192255 287280 361765 100912032 114212 58936 58822 287772 292766 64156 29669 171102 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 96%10222983 Cobalamin (Cbl) metabolism 290947 313520 362134 81522 291939 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%10224067 N-glycan antennae elongation in the medial trans-Golgi 308757 432392 25478 362275 367252 25197 313536 25547 494342 117523 140568 65196 303100 291325 65271 363040 29582 24375 299756 303923 94273 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange 290805 308755 497672 291787 64557 306734 305000 303194 140583 300711 499966 64046 360588 497856 85482 64012 499870 192218 MUSCLE CONTRACTION%REACTOME%R-RNO-397014.1 Muscle contraction 140448 300838 24244 140729 25650 363925 29389 29388 171409 56781 171009 295929 25262 295261 296369 64362 24585 25391 24583 24838 25390 24837 290561 58814 29600 64672 24211 24212 24213 294141 689560 63847 312981 246150 63848 171138 362013 25470 29248 58950 63883 58971 681190 305679 308405 367302 117018 64190 24907 116831 84020 59299 29639 116649 29132 83535 361618 25560 89821 29712 276720 64120 116600 50688 300992 140725 24239 116601 29599 29598 81678 29693 25400 24245 24246 64119 114593 116695 56817 140728 116564 140727 65023 171140 364241 259243 65180 156873 65199 24603 24602 289596 65195 81818 84429 59324 170899 688996 116489 445371 65272 116491 29715 113902 288057 304816 24598 66012 25202 296313 289759 24852 24590 24851 25687 25118 25206 29431 171115 500450 501203 282843 24584 29432 50685 25679 360820 140447 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 96%10222901 Activation of GABAB receptors 116649 680149 84420 50599 58979 29713 83633 29712 29718 114117 116560 24400 64508 81667 81664 64199 286924 24611 79218 81636 245986 60449 302950 294962 64532 25686 81657 25289 25643 83579 25743 29241 170847 AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 96%10225317 Amino acids regulate mTORC1 310091 298514 362045 64226 297960 297522 297932 298103 289407 362802 368044 100362347 298451 299971 170667 436582 297566 363138 312488 117596 94170 303185 116664 500843 366545 305464 360497 362441 362573 295357 690751 360969 26954 502988 117044 117043 56718 304410 360776 308869 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%10222741 Asparagine N-linked glycosylation 288525 294400 291095 310935 299346 305291 367252 315059 293719 313231 315212 300668 362031 362547 362599 81726 287427 361014 367073 29489 81754 680465 81655 309678 29564 299075 252902 292074 501550 24375 94273 308757 140734 29468 432392 25478 58945 64156 117263 50592 50522 311204 192255 100912032 298012 252929 24827 29640 303923 363109 297393 498272 297417 362275 498486 360518 302972 81759 313536 501167 300741 494342 302915 300089 65196 24210 29403 25128 140808 303100 65271 362625 295319 29582 299756 81519 297522 64202 29183 64154 29144 289994 293456 64310 362162 361073 296394 54350 287276 502017 309451 60355 65134 297428 290994 300888 246117 79120 304290 54400 58842 363136 690252 171121 192243 299850 25547 310411 311530 24648 316642 300743 64462 116696 298071 100912115 56042 117523 252853 365984 303692 89868 140940 363103 60384 25280 117185 290659 64351 304860 65165 301155 291325 300674 291990 407765 363040 25423 685144 64442 299121 64445 287920 362237 306264 29758 316033 309010 114711 140673 364901 503165 246310 83505 690961 313139 25197 361705 301012 362924 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 304978 116666 117513 100360302 94189 116643 29167 84428 79117 361207 252889 58817 93646 314030 295461 294010 361577 289257 305614 64159 314251 308458 140568 298541 311847 293587 295051 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-RNO-446388.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 57341 363509 362973 81634 29460 360820 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-RNO-1480926.1 O2 CO2 exchange in erythrocytes 25240 54231 29242 310218 24440 304805 360504 65207 24779 171015 365345 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 96%10222899 Adenylate cyclase inhibitory pathway 286924 302950 84420 24611 81664 64532 25686 25289 25643 81636 64508 29241 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-RNO-4570464.1 SUMOylation of RNA binding proteins 113975 287662 292085 295692 60373 117021 362335 366016 58958 307151 362557 65274 113929 297522 245922 81738 313038 683983 53372 309626 25497 499974 117282 310258 303730 25573 301442 499417 294429 287830 291874 362281 501403 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224677 Phase 1 - inactivation of fast Na+ channels 259243 65180 65199 65195 116695 56817 65023 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%10222415 Developmental Biology 140729 84009 140724 78966 306790 316009 300802 24511 29192 116690 292788 295378 29302 498416 296456 81751 25573 304109 310192 301442 313644 29491 289231 366492 83800 54241 140694 116563 300250 310207 25615 84482 64465 292848 291754 102546758 24332 302934 313672 310575 294094 60335 499345 308564 292949 682408 293619 408235 287925 291760 689230 24185 299587 295190 25233 25094 309528 361319 690660 307563 50645 316539 116683 310643 84358 79208 171287 94268 298528 312279 29210 116470 29414 81732 85252 307562 289820 297518 59312 65046 60629 315615 116743 25416 161452 171119 299737 140670 81515 81521 117273 50687 83805 288669 171574 84393 306871 24408 54319 24410 29495 312451 360854 50554 81824 84353 25631 54227 81679 291755 25751 83510 29423 362993 293508 301252 29357 60352 64030 304822 286908 58960 361364 502694 116590 498898 140908 291759 116671 24680 25513 25454 25738 366508 170577 24923 170911 305417 60664 84477 252892 25453 85243 57033 85385 306013 306636 287989 83709 66023 686310 316369 29376 114559 25676 361388 312275 24338 29433 24252 314850 83841 300242 360546 300247 363875 312477 300248 685269 303519 680454 102553726 450230 24553 100364550 246331 24705 294853 25525 450228 134481131 79114 450227 690478 24329 299331 450229 81687 100359886 497995 81686 369017 450225 100361571 407757 407758 266717 120095335 287701 287700 287702 680104 287697 84578 287699 406227 25622 287698 297893 406226 406228 25626 683313 296789 680060 308376 65208 120093742 313498 362572 312213 680703 407762 310630 361568 134478810 25418 315320 294515 309280 102551497 60427 311384 315324 170851 25415 407760 25417 315323 315711 680152 361597 315318 363517 100363184 685544 29751 289392 360626 361537 360623 25720 287675 303523 303528 287679 303527 680071 100909661 286912 24716 25136 81650 364686 314641 84347 140725 311860 83501 361882 171046 116549 316639 116696 117516 117523 24718 266729 361432 306400 309757 25537 25311 94201 25664 499497 297357 337868 25714 81518 498607 84027 299766 29148 360715 309957 84382 360600 292028 353305 360034 300955 361604 29361 290868 291624 64373 306804 25017 116483 287191 288480 289352 24605 289257 293621 305614 64159 306628 24586 314251 81504 25614 24525 25150 81822 81646 313845 290905 308458 50689 50938 24699 81771 29431 501203 287876 29432 84427 84357 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-RNO-8964616.1 G beta:gamma signalling through CDC42 680149 58979 79218 64465 363509 114117 24400 245986 60449 81667 294962 29431 83579 64199 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B 64156 296368 50522 64515 305420 361831 366381 292588 361389 293155 25203 54237 192255 100912032 360643 288671 290875 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 96%10225077 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 50662 361391 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane 24392 394266 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%10225045 Carboxyterminal post-translational modifications of tubulin 298692 292311 311548 690512 689746 315214 362415 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-RNO-1971475.1 Glycosaminoglycan-protein linkage region biosynthesis 50568 25181 29139 25592 25393 114122 691984 171517 116673 24771 304885 315939 298690 317322 25236 246232 81651 25216 25615 58920 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 96%10223027 PI-3K cascade:FGFR2 29349 29348 25444 25443 54250 361388 25622 25317 170700 314850 29369 29368 170633 60464 25513 170583 116499 60662 170911 170579 25022 66017 81504 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 96%10222719 Gamma-carboxylation of protein precursors 81716 306608 29243 24946 25268 260320 25295 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-RNO-9614085.1 FOXO-mediated transcription 24185 84482 56011 60331 293615 25233 309757 29414 50554 301164 313558 25631 56010 294515 25578 25577 313017 29357 24370 302415 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-RNO-9614399.1 Regulation of localization of FOXO transcription factors 24185 84482 56011 294515 25233 25578 313017 25577 29414 313558 302415 56010 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-RNO-9018677.1 Biosynthesis of DHA-derived SPMs 114097 499689 287454 29527 29328 79242 81639 29277 171522 25086 299732 24296 24297 266682 252931 65030 25290 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%10224351 Pre-NOTCH Expression and Processing 56761 304815 84006 65165 406162 GALACTOSE CATABOLISM%REACTOME%R-RNO-70370.1 Galactose catabolism 313843 298003 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%10222671 FXIIa, PKa activate coagulation factors 24946 116727 25087 691992 502858 25259 306761 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10222273 Organic anion transport by SLC5 17 25 transporters 362188 170943 363103 64201 29743 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-RNO-434313.1 Intracellular metabolism of fatty acids regulates insulin secretion 113976 114024 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%10224605 SUMOylation of DNA replication proteins 113975 292085 295692 83614 117021 362335 366016 58958 362557 65274 362827 113929 500545 245922 81738 683983 53372 25737 25497 499974 690244 64550 25573 361100 301442 499417 64041 114592 294429 287830 291874 362281 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-RNO-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 361925 301020 83833 292404 303518 293514 296732 361825 368001 287876 297867 361295 305589 361711 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223887 Interleukin-33 signaling 25556 25466 361749 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%10222985 Cobalamin (Cbl, vitamin B12) transport and metabolism 290947 313520 29319 314459 80848 362134 81522 29216 291939 24565 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 96%10224185 TWIK related potassium channel (TREK) 170899 116489 65272 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-5632681.1 Ligand-receptor interactions 84399 84380 89830 50938 29499 INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling 25125 24514 100361294 171333 689932 25506 155140 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224213 Downregulation of ERBB2 signaling 24185 117255 25233 362814 25433 25313 114562 498596 29414 64156 296121 64022 64624 50522 24329 299331 432361 192255 29496 287155 100912032 59325 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 96%10222919 Signaling by Activin 29200 25366 29610 116590 114031 50689 50554 24373 25631 29263 29357 245921 24504 25196 29381 FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-RNO-5654700.1 FRS-mediated FGFR2 signaling 25444 25443 54250 25622 29369 29368 170583 24605 60662 293621 170579 25022 66017 81504 29349 29348 24525 313845 170700 25317 314850 170633 60464 116499 316213 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%10223455 Insulin processing 294698 299903 305287 24506 64632 24505 60627 171455 116654 252881 50556 245709 25506 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%10223515 Ligand-independent caspase activation via DCC 25402 25311 58918 PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase 140729 246150 116600 171138 24239 50688 63883 681190 300992 367302 140725 140728 84020 140727 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 58960 116590 296456 116549 50689 363875 685269 50687 81650 246331 29431 79114 170851 24329 24511 24586 29302 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223843 Zinc transporters 361986 300051 58976 294698 295455 299903 294281 291733 305846 306009 314637 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%10222607 COX reactions POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224097 Potassium Channels 680149 27150 58979 114117 24400 81667 25736 246153 83588 307234 29738 25470 116695 117018 84020 25743 170847 116649 83535 25560 65180 50599 29713 83633 29712 29718 25559 116560 65195 25472 276720 84429 59324 170899 688996 116489 64199 445371 65272 116491 79218 25468 246325 245986 116745 25327 25469 294065 60449 295360 114032 64120 66016 117023 29747 171011 84390 65198 66022 294962 294961 365241 59266 83731 170739 24520 54262 81657 58981 54263 296395 310303 259273 114244 29737 114245 60326 171146 83579 29731 307900 684516 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 96%10222347 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 171155 170670 64304 140547 113965 INTERLEUKIN-10 SIGNALING%REACTOME%R-RNO-6783783.1 Interleukin-10 signaling 25125 100361294 304091 25325 ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism 100363253 24172 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-RNO-2187335.1 The retinoid cycle in cones (daylight vision) 313689 81644 293049 24711 302425 89810 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%10222331 Eicosanoids 298423 24886 25527 286904 24306 299566 503122 50549 24307 290623 266674 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-RNO-450520.1 HuR (ELAVL1) binds and stabilizes mRNA 24680 25379 170538 363854 307947 85252 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%10222609 Initiation of coagulation cascade 29243 24946 260320 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225165 RAC1 GTPase cycle 292279 306618 287537 287418 84009 311647 308666 78966 682937 117020 25513 303634 301334 170911 60664 100362710 24511 362648 295378 298404 29528 83709 363509 114559 140898 361921 29433 304109 310192 307016 292756 363875 64678 366492 304546 114513 64465 366608 313438 305987 315992 25437 29448 303501 317598 309696 310833 360678 306183 313388 78967 314249 312108 83620 308097 306357 688429 362456 314618 367085 314903 305367 304282 29146 316639 303222 287746 498282 500246 361029 360509 64630 290396 308509 299012 64351 29355 363235 679934 306279 246249 500287 362893 288093 307459 305156 306400 310074 315348 25096 315121 310621 29579 25097 361617 66021 84031 300067 300186 313024 360840 303583 308869 117542 304530 303653 114116 58823 114243 79129 305938 63994 291694 302976 313845 311450 311793 308021 29431 84014 295635 286928 307035 79249 29432 294568 100360623 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%10222017 Glucuronidation 266685 63867 501907 286954 303953 286989 246232 24861 83472 113992 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%10222197 Programmed Cell Death 304822 116590 170538 64639 116554 292994 24493 287155 266610 246097 25385 690743 56816 501083 25402 306886 298534 64665 246756 246240 64026 363836 100360940 246142 117279 114562 83764 25318 83841 64547 116502 287606 25309 64625 171528 259274 24170 365191 296654 299331 690675 56011 367786 24888 171116 298282 29197 29753 29748 353316 311567 282834 25576 25578 364419 25577 363720 361916 287873 679886 305884 307562 60371 83497 313017 24917 171378 492821 140734 58945 64156 25311 498072 56010 291145 680522 306871 201097 361092 84359 684828 114114 317589 24437 63879 78963 295961 316164 116685 26295 84353 50522 81818 192255 24205 64159 100912032 299606 25614 291755 83502 50689 448830 364867 363328 60350 64044 29260 58918 305549 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA Damage Checkpoint 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 113927 140583 81827 83806 311078 303024 192255 287280 361765 100912032 114212 58936 58822 287772 292766 64156 29669 171102 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 96%10225471 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 690660 297893 161452 84353 312451 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%10222059 Transmission across Chemical Synapses 680149 25302 79211 84420 66013 140675 58979 25023 363447 171571 24244 140729 25674 501560 84591 114117 24400 60422 140724 64508 65187 170945 29642 25050 192258 24397 29695 81667 29694 24681 84016 29699 79130 24680 171503 553106 81664 191573 60341 24957 29483 170567 29482 24904 25553 29503 25716 64830 24898 116638 293645 64832 79212 25558 25549 83612 140592 84556 79213 25012 171163 116563 315840 24468 25743 170847 116649 50599 29713 83633 29712 29718 116560 308868 54257 29559 66028 58942 25297 25398 84347 116600 50688 306243 300992 140725 60355 116470 25531 24803 29647 24379 81632 497009 24949 24380 83589 29179 60442 29130 50676 65046 140670 64053 24409 24408 24410 25400 24245 24246 24412 24411 29629 29628 29627 83613 29495 50592 25252 171140 117284 58948 85426 29539 366432 64199 60377 25550 286924 83506 24611 81646 24398 79218 29709 29708 25103 81636 29707 245986 29705 192268 84012 29422 54239 60449 171131 24947 24267 293508 81771 25753 302950 54240 117269 25590 81721 294962 79246 64532 58963 25521 65024 25686 298521 81657 25289 79557 24407 25643 24406 25725 25456 24922 24679 59317 83579 29241 25451 25450 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%10222013 Glycolysis 25741 24651 24334 316265 315722 292804 25060 292138 24189 296973 289608 54283 25438 685076 24385 66020 100364027 24638 24959 60416 498731 24191 24849 25059 294429 24640 24642 287830 25658 291874 362281 117276 113975 65152 292085 295692 117021 362335 24644 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 96%10224381 Linoleic acid (LA) metabolism 363516 498728 83512 84575 309449 171400 25288 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 96%10224505 SUMOylation of DNA damage response and repair proteins 308755 497672 297561 25573 313304 301442 299957 499417 63996 313961 300772 691688 690043 363269 361645 293528 102551929 294429 287830 291874 362281 113975 287662 83422 292085 25591 295692 308669 117021 362335 293967 366016 58958 307151 362557 65274 362827 113929 297522 245922 81738 313038 683983 53372 309626 25497 499974 310258 303730 690244 501403 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%10222055 Astrocytic Glutamate-Glutamine Uptake And Metabolism 24957 29483 170567 29482 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%10223467 ABC transporters in lipid homeostasis 300664 301482 155192 25081 302973 25270 83519 363516 84356 114628 286970 303639 287788 79248 299609 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%10224499 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 308384 25573 301442 304132 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling 25614 25150 64465 300955 310192 25311 363875 83805 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 96%10222107 Glycogen breakdown (glycogenolysis) 64035 81675 307091 362029 24244 678739 29353 361377 140671 367562 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%10225371 Regulation of NF-kappa B signaling 315599 500900 64156 311245 50522 291861 309295 312688 291921 64044 309361 192255 100912032 84351 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 96%10221923 G1 S Transition 117281 84389 29414 295596 299112 312538 360908 316273 296178 313479 682033 362485 291927 307126 360621 304573 308937 59102 29728 312046 298098 292071 83571 301430 288532 287772 366275 292766 313138 64156 94201 29669 171102 29668 362385 29425 100360846 499655 307585 117263 25581 29666 303353 365388 117262 85492 24708 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 114494 287280 301323 100912032 24185 85241 315648 25233 266713 58919 24673 24672 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 25444 25443 54250 25622 29369 315761 83504 29368 170583 25513 170582 25718 246273 29516 60662 170911 361992 84477 170579 25022 85243 85385 66017 81504 29349 29348 84489 313845 25233 29376 81745 361388 363131 170700 25317 314850 289625 170633 24483 65052 60464 24482 25467 79114 116499 25114 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 96%10225203 Biosynthesis of aspirin-triggered D-series resolvins 299732 25290 29328 M PHASE%REACTOME%R-RNO-68886.1 M Phase 25023 65158 498266 315508 300149 305392 680089 362519 362438 25573 301442 365191 498265 60336 307169 684771 308870 305343 304218 290577 313861 29753 306464 679342 287624 291441 25437 257649 307947 257644 64041 25448 94266 682908 29489 307351 282834 81754 363028 291081 364419 500377 315164 307833 304951 363720 289150 361916 361416 246118 363174 84509 500363 81655 303037 313478 679312 287873 300218 363059 114764 246772 29564 679886 498736 286993 114514 114087 298850 362700 83836 363198 362548 304477 298594 170845 252902 85252 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 24917 317252 363481 305270 83572 140734 681050 58822 58945 684439 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 24708 287984 65138 94198 25515 29673 116685 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 292263 500929 25203 83806 311078 192255 100912032 360643 315648 363193 309179 24673 24679 316737 287447 24672 117281 116590 24680 692032 64158 311573 309098 311802 311529 290626 300963 315423 171566 362203 683722 29479 363055 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 316531 296554 287929 310344 680991 312754 314787 60347 29214 246150 500069 299331 362980 29213 81740 192228 294429 307347 287830 305882 291874 362281 299147 113975 299204 292085 295692 117021 362335 366016 58958 24669 362557 65274 302783 113929 24829 361308 24828 297522 245922 81738 315740 683983 53372 25497 685909 680615 499974 303175 64627 306970 689820 81650 317425 306945 365877 116549 299850 690795 117104 64462 313304 64528 63996 56010 29167 294010 290668 50689 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223373 Basigin interactions 116726 360606 65200 84551 50567 25390 25650 83509 50687 50719 29409 25518 300338 25246 24511 25027 80878 307811 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223531 Other semaphorin interactions 306790 313498 310630 311384 315711 363517 310207 296789 361537 24699 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%10224777 SHC-mediated cascade:FGFR4 29349 24525 313845 25444 54250 25317 170700 289625 29369 29368 60464 170583 170582 116499 24605 293621 25114 85385 66017 81504 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%10222763 Mitochondrial transcription termination 85261 PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors 24590 113902 24603 24602 289596 114593 116564 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225419 Transcriptional and post-translational regulation of MITF-M expression and activity 116590 292028 353305 29414 29361 290868 85252 291624 306804 117516 116483 287191 288480 289352 60427 170577 25094 690660 309757 25573 50689 301442 81771 64030 84027 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222727 PDE3B signalling 29516 SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism 310849 353229 366065 362275 500624 296188 65183 366697 307855 360833 294673 308589 361213 310667 366984 500961 316642 499210 313339 65196 365984 286896 301118 246115 309147 117185 407765 64442 64445 25524 316033 364901 83505 81919 58924 63888 80773 64828 683713 50555 312689 300129 83626 310508 58970 116740 363494 114104 303729 25227 311013 83537 303631 289687 94338 360618 315222 24800 365619 310326 684536 362409 170897 307404 84431 499174 312382 300757 314438 301525 500651 24565 304208 100270678 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%10222565 Fibrin formation 60327 79224 29366 24366 289055 24367 304917 25268 65051 685269 29302 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation 306825 54241 116563 192255 298296 65046 64156 140670 50522 100912032 58851 83800 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223347 G-protein beta:gamma signalling 680149 24185 58979 79218 25233 64465 363509 81745 298947 114117 29414 24400 245986 497931 60449 117273 81667 497932 294962 29431 83579 64199 MITOTIC ANAPHASE%REACTOME%R-RNO-68882.1 Mitotic Anaphase 117281 64158 25573 301442 316531 296554 365191 312754 29213 294429 287830 291874 113975 299147 292085 295692 684771 117021 362335 305343 304218 366016 290577 24669 362557 297522 81738 683983 306464 679342 287624 291441 25437 257649 257644 64041 25448 682908 94266 29489 307351 282834 363028 291081 364419 500377 315164 307833 304951 363720 361916 289150 246118 361416 363174 84509 500363 81655 303037 313478 679312 287873 300218 363059 114764 246772 29564 679886 498736 286993 114514 114087 298850 362700 83836 363198 362548 304477 298594 170845 252902 85252 117104 287598 307805 311191 29648 500545 102555739 295661 65201 681185 308443 296137 24917 317252 363481 305270 83572 140734 681050 58945 684439 287772 292766 64156 313304 296368 29669 29668 63996 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 287984 65138 94198 25515 29673 116685 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 500929 25203 83806 311078 192255 100912032 360643 315648 363193 309179 24673 24672 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 96%10222771 AMPK inhibits chREBP transcriptional activation activity 373545 64562 289036 312670 246253 78975 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-RNO-2299718.1 Condensation of Prophase Chromosomes 303175 25515 365877 64627 306970 307947 690795 689820 302783 24829 24828 315508 300149 25203 54237 306945 317425 685909 680615 24708 362519 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes 114764 117281 83836 299850 64462 311191 692032 64158 311573 309098 311802 311529 290626 300963 315423 83572 171566 362203 683722 29479 58822 363055 58945 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 56010 316531 296554 287929 310344 680991 314787 60347 246150 29214 54237 299331 500069 362980 29167 29213 81740 192228 307347 305882 294010 25515 29753 29489 24679 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-RNO-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane 313648 363160 499342 64701 290783 362040 116967 192275 100188932 309304 290638 686092 301626 SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors 117273 ACETYLATION%REACTOME DATABASE ID RELEASE 96%10222689 Acetylation 290681 116632 116631 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%10222943 Terminal pathway of complement 24237 CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism 85254 290551 291450 81508 114123 64037 363024 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER 306274 360471 362479 292778 84389 288651 288588 361580 366163 497967 502227 245976 299112 294693 50522 83503 361365 84495 690966 117017 291703 363633 498109 192255 289561 288003 361698 171525 304573 25737 302502 100912032 59102 288414 361181 289758 116468 59294 89809 246216 298098 64156 266713 362385 362394 314061 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME%R-RNO-9860927.1 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 311860 25614 117281 315648 296456 24627 56611 81666 29156 309295 117104 24697 81736 29154 25493 81662 309361 305679 24511 363014 84351 29302 24672 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225057 MET activates PTK2 signaling 25614 24553 360606 170921 24511 691517 309816 24446 83805 PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway 688319 25023 24681 24680 362550 314212 306782 84426 100360552 266715 140584 287772 292766 65046 64156 29669 64558 140670 363875 29668 117273 29425 83800 100360846 116561 54241 117263 25581 116563 29666 303353 365388 117262 85492 364754 287984 65138 24881 94198 64512 317674 29673 25388 29671 29670 29677 29676 29675 50522 282581 81827 303251 83806 311078 192255 303811 100912032 83721 690516 64303 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-RNO-110313.1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 295704 289508 299112 50522 316344 292101 313702 140639 309812 192255 298693 288003 361698 171525 304573 25737 100912032 59102 288414 289758 116468 59294 89809 298098 307905 64156 362385 84478 300795 100147704 316235 116643 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-RNO-179409.1 APC-Cdc20 mediated degradation of Nek2A 64156 296368 50522 64515 305420 361831 366381 292588 297176 361389 293155 192255 100912032 360643 288671 290875 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223965 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 25302 25590 81721 65024 79557 25103 170945 54239 171131 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport 688685 498185 298203 307350 114766 171433 301418 353231 365567 64198 25344 364601 295462 287979 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 96%10224921 Transcriptional activation of cell cycle inhibitor p21 685474 24842 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223961 Presynaptic nicotinic acetylcholine receptors 25753 54240 25590 81721 79557 25103 170945 29422 54239 171131 SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions 304297 360652 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking 25751 24600 311111 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling 117281 116590 25444 54250 25622 29369 50522 29368 500526 306141 170583 192255 60662 100912032 66017 81504 29349 84489 50689 25317 64156 314850 83805 114486 60464 116499 24673 500985 24672 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9937383.1 Mitochondrial ribosome-associated quality control 301250 301371 364656 287302 293666 296134 64360 303685 113958 294767 684304 680747 301352 290850 297372 301240 498406 303746 295238 293054 309176 298517 293754 297799 361883 363023 301552 299628 497876 683519 315141 288916 294230 309140 100363539 360594 500199 299938 292758 287962 295224 296551 171061 292244 363646 689432 293453 361005 310653 362216 297601 56281 309440 287656 297459 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%10224231 Acyl chain remodelling of PC 297694 311341 362434 192259 289733 296048 360426 361467 362039 691905 314075 29354 24913 29692 295631 298579 29526 313997 29359 690610 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224217 Collagen degradation 100169747 300341 25697 117033 25335 362347 685612 63849 117061 29175 54281 315388 291848 499431 300338 81687 81707 81686 103690254 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 96%10224871 Fanconi Anemia Pathway 304719 362678 292127 314172 50522 312641 309256 100360594 310745 691105 499155 192255 363164 100912032 287634 59102 293489 501552 502320 685055 303742 64156 302982 360847 313387 302953 293678 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%10223425 Synthesis of Leukotrienes (LT) and Eoxins (EX) 114097 94199 24307 290623 116568 266674 29624 81639 291984 298423 299732 286904 29566 24306 299566 503122 25290 50549 24565 289014 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10223587 Serotonin Neurotransmitter Release Cycle 25558 25549 140592 84556 25012 116470 25531 24803 24949 29179 29130 25716 64830 293645 64832 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-RNO-9730628.1 Sensory perception of salty taste 24768 24767 25122 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex 680498 365877 295596 690795 312538 316273 296178 313479 291927 360621 362607 24917 29728 292071 301430 288532 287772 292766 313138 64156 296368 29669 29668 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 310678 305420 361831 302783 366381 24829 292588 24828 81827 293155 83806 311078 192255 117056 685909 100912032 680615 360643 303175 64627 306970 306945 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224039 Negative regulation of FGFR1 signaling 117281 116590 25444 25443 54250 25622 83504 50522 29368 500526 306141 170583 192255 60662 170579 100912032 66017 81504 29349 50689 170700 25317 64156 314850 83805 170633 114486 79114 116499 24673 500985 24672 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224481 Beta-catenin independent WNT signaling 680149 688319 25023 58979 24244 114117 24400 365901 81667 24681 24680 362550 314212 306782 84426 100360552 266715 497961 140584 50664 287772 292766 65046 64156 161452 29669 64558 140670 363875 29668 117273 29425 83800 100360846 116561 54241 117263 25400 25581 116563 29666 303353 365388 117262 85492 364754 287984 65138 24881 94198 64512 317674 29673 25388 29671 29670 29677 29676 289878 29675 688297 84353 50522 282581 81827 303251 83806 307401 311078 192255 303811 100912032 83721 64199 24525 29748 79218 100361818 24674 245986 24675 690516 60449 64303 294962 313121 83579 LDL REMODELING%REACTOME DATABASE ID RELEASE 96%10225367 LDL remodeling 310900 25506 MITOCHONDRIAL UNCOUPLING%REACTOME%R-RNO-166187.1 Mitochondrial Uncoupling 85263 25708 54315 24860 85333 498226 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223111 FGFR3 ligand binding and activation 29349 84489 25444 54250 25317 29369 29368 60464 170583 116499 60662 366061 66017 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 96%10224613 SUMOylation of immune response proteins 25493 83614 690244 25573 301442 309452 309295 362827 ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223169 Estrogen biosynthesis 116463 296972 289456 25322 691018 79243 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-RNO-69231.1 Cyclin D associated events in G1 311860 117281 294790 84389 64033 114483 399489 50522 117104 81758 682033 25193 362485 24514 192255 287280 100912032 684111 100360427 315648 25164 83571 366275 64156 494444 94201 680111 266713 81515 361178 83805 499655 24673 58919 24672 24708 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%10222701 Conjugation of benzoate with glycine 293779 246263 688536 PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling 315707 116689 25622 310678 315606 302783 24829 24828 117056 685909 680615 303175 64627 306970 304794 81650 290829 58919 306945 362093 680498 365877 116549 690795 287772 292766 289874 64156 94201 29669 290783 65248 29668 362040 56010 29425 100360846 116967 83712 290823 117263 192275 25581 407784 64562 29666 313048 100188932 303353 116643 365388 309304 290638 686092 117262 85492 301626 25520 83803 84027 287984 313648 65138 362891 94198 373545 688041 363160 29673 301555 499342 29671 287643 29670 64701 29677 690315 29676 78975 29675 360967 294269 50522 300678 313050 24981 25300 25710 24986 81827 24932 83806 311078 192255 287280 361765 100912032 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%10222117 Ethanol oxidation 310903 298079 24188 100145871 296259 29539 171178 24172 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 362625 295319 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-RNO-9769743.1 Amplification and propagation of coagulation cascade 24946 116727 691992 502858 65051 25259 315272 29243 302470 79224 29366 304917 25268 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%10224259 Synthesis of PG 114101 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%10224175 HCN channels 84390 59266 114244 114245 METABOLISM%REACTOME%R-RNO-1430728.1 Metabolism 50568 84018 25181 300993 404783 294324 367166 24434 363513 404280 25413 25756 25757 25736 246153 83588 689588 307234 25502 24314 24609 25573 499417 116482 54231 29242 310218 362827 302899 25426 24848 24311 317675 266807 25699 266761 114613 311374 29475 25085 25120 24661 79107 25430 308129 246281 65162 291671 500132 313450 309419 25751 116484 301252 287420 81643 288259 684425 315150 117544 289276 140946 295934 316737 300757 301525 291015 303923 316583 305571 84400 362275 84468 293667 367145 307859 140547 294673 314771 113965 292073 64507 313536 500961 494342 299825 81682 58968 65196 24886 25527 25526 25738 59103 362039 29224 691905 29354 24913 29692 308309 295631 298579 29526 29359 297694 362972 678749 84497 296849 252900 311254 299331 25682 363026 292894 308190 84578 289950 298942 81654 24172 81530 89813 362809 117098 365755 302711 315973 500709 246074 171410 83512 289125 24600 296851 94199 312495 171402 171400 298184 310848 170897 359725 170465 140868 25288 25045 361802 303577 291984 266604 361895 498728 29411 84575 309449 170570 64310 113976 26759 54398 364134 100363074 29510 114024 24159 94340 117243 25363 300783 619561 64304 100911581 680115 301120 191576 301024 140940 29254 499570 300108 25598 64822 79131 25062 79223 362732 296130 681211 29653 80841 29562 501157 690945 81678 287479 314140 83688 362383 29337 64524 362706 24689 100360180 299201 360975 365592 296128 498332 366013 299195 362638 311580 25249 24479 311864 288051 313521 65156 29309 29244 291585 304944 308453 24240 498909 29498 291824 171128 304542 50655 314800 360887 29270 117099 24450 295458 367112 65984 366463 690163 288740 292845 298748 293655 81728 50567 298147 691506 293130 497902 500052 299310 499529 686506 361385 497863 681418 301011 301458 300047 296658 301416 317444 297821 102550385 300726 362440 366448 303922 289218 25679 293114 301427 64539 361520 120097699 362495 296190 362810 293448 678759 294973 291103 100912357 315167 362588 296086 361894 685322 690354 301123 56769 50719 497932 25262 85260 64467 309390 678739 89842 316077 613267 29353 314312 361377 140671 367562 690987 64035 81675 307091 309513 362029 293620 170698 314553 58978 140860 361676 308518 291075 114027 503049 311446 303272 25541 24451 85255 311849 50559 64001 79244 50681 84114 24902 360826 84470 24912 300983 64473 293991 64305 29725 288617 297433 360268 114209 361510 113956 503103 58953 79238 306460 307170 312952 360753 83783 85239 84029 171072 60418 292915 24792 688293 65183 64537 360630 64461 368128 308652 25611 685325 363516 314304 83842 299857 83522 501072 289036 65192 312670 24239 171142 246253 171078 81747 364629 24917 116720 290985 287772 79250 114597 292766 64156 287069 298596 29669 362323 25097 157074 29668 498226 29425 170587 100360846 310378 24368 25429 85263 25708 117263 362360 499125 298369 25581 502348 54315 29666 363061 24777 24860 498331 259221 25428 303353 289217 296461 365388 114096 79111 361726 25440 117262 94173 311129 85492 246211 60351 303497 287984 301517 65138 303879 83569 94198 83724 362782 29673 309527 58970 300790 140668 29671 192242 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 64199 24654 306808 50560 59268 79218 171458 305419 360618 288762 361632 363131 114554 245986 307842 116699 309855 60449 25031 316457 80849 293508 65052 85240 310155 29189 294962 29611 64532 25521 25686 293453 171133 25289 25725 317296 24679 302425 83579 287380 293173 680149 679520 58979 29139 25592 24244 25393 114117 24400 114122 25488 24307 81666 290623 81667 266674 24894 29699 24299 499330 502969 24680 81662 298423 316062 81664 24895 25668 24778 313375 286904 306262 361300 24306 299566 29142 50671 503122 54246 171053 361378 367323 171178 85496 50549 499328 64392 293504 300886 297508 362249 300328 353255 311821 64845 79213 313241 309111 313520 117100 29319 25374 361751 310864 681896 311536 25035 25279 361472 114700 687008 25551 312689 100125370 361836 289095 64152 170551 288240 282821 25694 301221 25083 304885 64533 293154 315939 361663 298690 310856 29723 266805 24312 24175 81506 314459 361884 362134 299699 83578 291939 680308 303333 307428 362657 287533 83535 751787 295674 64300 315085 301131 305935 295229 294972 246237 25732 282584 298653 308584 25559 367786 80848 363118 289021 305248 360521 310663 50622 114561 54349 306490 60581 50621 361659 25748 365699 65155 362942 289219 691853 309391 296732 309070 25044 304024 361338 360816 65151 363494 114104 310773 303729 29367 25227 89841 360843 311013 83537 29194 303631 25697 289687 94338 315222 24800 365619 310326 684536 362409 307404 84431 81650 314641 116549 316642 365984 363103 117185 407765 363040 64442 64445 316033 364901 366064 83505 81919 296564 362924 84597 362474 288161 100301568 25747 301624 58924 25750 361694 287467 304474 192260 81925 24873 497991 64562 290277 171408 316067 290638 373545 499353 288517 78975 83784 25134 25721 306586 298079 292710 298490 298934 287711 81508 29539 81805 360639 288912 363069 25256 296167 298227 294088 360511 81718 691966 79462 367181 83586 310201 246245 170943 293653 25274 57300 192172 365972 171451 309732 100145871 303953 305177 296259 25315 291084 171445 29473 26760 116723 25375 304078 310903 89812 84493 313706 25571 399684 309004 300447 246311 54705 24861 312382 25303 24565 24360 289014 365865 140607 116599 79239 292737 24470 682974 29632 305291 298504 25146 64677 25511 286936 24950 84013 140544 360348 117182 362322 64201 288025 24551 362434 81829 316039 24401 680971 114101 498741 288322 287115 25242 25243 291577 296623 362058 498999 291770 297554 85311 500257 287366 304322 314075 60666 302302 363159 314694 316533 681694 170919 361433 313997 690610 290843 293711 361686 691478 305166 24539 63888 691984 171517 64828 24710 683713 25703 50555 24856 300129 25702 83626 25680 310508 192259 116673 24771 299858 362558 300027 64047 317322 25236 296972 29216 25216 315644 25615 58920 314941 25056 64633 55939 29688 289456 24250 25322 691018 24962 79243 116463 59326 116740 497811 360670 117267 294103 295443 306866 94197 24185 84509 25406 300147 100169747 25532 287424 287425 24404 308445 497197 24655 282636 688862 246136 308451 171088 94267 81677 294292 140693 85238 365382 290651 316376 114633 54260 50690 83523 24264 252899 24265 50676 81660 25095 290029 362015 192357 79127 24165 64045 117533 290741 24465 25028 294521 313560 25368 298410 297389 292072 102238592 58964 362720 24183 24184 311833 299976 685579 29223 83782 365985 29261 619580 191575 497778 64037 116700 25329 50557 363024 83529 85333 113902 294255 25287 171155 170670 85254 293779 353317 246263 688536 361637 24782 114097 499689 295417 315439 117543 24158 65038 499210 25513 313339 286896 301118 246115 309147 366508 54259 170911 60664 85243 29726 298947 497931 287454 29527 29328 29624 79242 81639 29277 171522 25086 299732 24296 24297 266682 252931 65030 25290 294429 287830 291874 362281 113975 114089 292085 29470 295692 117021 362335 366016 58958 288731 362557 65274 305482 316559 113929 305889 680668 297522 303676 245922 289175 81738 683983 53372 312634 25497 499974 312947 498790 63865 266685 361401 311341 501907 286954 299270 286989 307092 25116 25117 291283 361266 171516 24186 313843 298003 307096 364773 498789 191574 25297 25398 116600 300992 499174 314438 500651 25649 304208 25728 100270678 310849 292697 54225 353229 366065 25080 500624 25081 296188 366697 307855 360833 308589 361213 310667 366984 54233 54232 298657 500292 499566 291819 302669 363085 290223 291541 311617 305150 24813 63864 29700 58835 29383 29711 361755 64040 291450 100360621 293871 290484 170907 309150 310152 85309 311358 306574 246307 29221 117024 64192 290551 66029 81640 84596 29592 298607 89833 81670 497840 681319 29215 170898 362428 361215 364064 64313 294421 59085 79251 29301 308800 364975 64564 64203 64206 56823 24513 171151 306840 25618 304429 29416 25612 29531 303306 296925 100365773 361272 312381 63938 311844 300723 289727 116682 301384 24399 24398 29603 81708 685999 25244 300384 25014 59113 192268 114123 246266 300035 116721 116593 315219 81656 289801 287368 65135 295620 312373 301005 63867 295088 498940 362329 290681 312086 116632 361992 116631 84024 300981 113992 25524 361596 25653 25309 690675 303218 294449 302489 293451 292155 295430 84406 26203 29633 26202 26201 363618 114002 364476 684979 108349781 299907 291211 293688 29637 25675 81726 619549 26195 298298 26194 81727 26199 29540 26198 29230 26193 308100 309262 26192 117278 114100 310645 83791 64191 81681 140910 78968 300095 89784 29580 266607 25051 363521 362702 24953 303393 29445 363285 25331 364298 94194 681024 683630 81522 171347 690050 29443 102555170 24267 140925 290947 171335 100188937 54322 366196 289733 296048 361467 24957 24377 84683 114508 25741 24651 362282 24334 25104 316265 315722 292804 25060 292138 24189 296973 289608 54283 25634 25438 685076 24385 66020 303565 25523 100364027 24638 24959 294321 60416 360229 498731 24191 24849 25059 295347 24640 24642 25658 29573 117276 24362 65152 293615 25514 654441 25282 688386 364686 24192 361730 684314 24188 24788 25659 245958 140608 300677 171082 94271 245965 252934 26197 26196 171069 170520 29754 362749 641434 690441 192241 171375 171374 65262 24439 294320 24533 24534 298982 83536 307270 315949 361602 497900 302980 290705 369018 64157 311111 80773 25096 289522 304735 291699 313786 24230 29680 25557 79122 246232 83472 24644 290401 64352 408206 116568 295037 291394 81869 25260 360994 494499 25283 29566 29487 681913 156275 297029 362196 24421 24423 24422 25458 29739 24424 24426 309465 494500 116684 501110 58962 78959 171341 311422 361068 171047 360426 100363253 361274 287406 305149 313574 117260 298881 81651 286974 361450 365583 297865 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME%R-RNO-9943962.1 CHD6, CHD7, CHD8, CHD9 subfamily 311607 680498 303175 365877 64627 83726 306970 84353 690795 310678 302783 24829 24828 103690021 65027 117056 306945 685909 362093 680615 312974 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 306608 29243 24946 25268 260320 25295 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-RNO-1834949.1 Cytosolic sensors of pathogen-associated DNA 84353 50522 81736 25493 301059 304859 64046 309361 192255 100912032 308901 313264 310461 64156 309452 309295 499069 293624 304987 299827 292892 287707 84351 314336 498840 APAP ADME%REACTOME%R-RNO-9753281.1 APAP ADME 83783 140668 408206 116568 291394 25260 29566 290681 156275 116632 116631 170924 300981 113992 24426 25086 116721 24902 24912 24861 312382 360268 25303 361510 24565 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224211 Downregulation of ERBB2:ERBB3 signaling 24185 25233 362814 432361 192255 29414 29496 64156 296121 50522 100912032 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN 292892 TRNA PROCESSING%REACTOME%R-RNO-72306.1 tRNA processing 319113 361201 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%10223855 Miscellaneous transport and binding events 114506 303070 64673 361069 305131 24171 305135 311846 304203 289443 290783 362642 308668 116967 308667 24170 310625 289594 65207 25230 287478 293048 79032 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222299 Triglyceride biosynthesis 79223 362732 296130 681211 29653 316737 84497 252900 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%10224805 RHO GTPases Activate Rhotekin and Rhophilins 297383 300030 117273 60377 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%10224051 IRAK1 recruits IKK complex 363520 309157 309361 116725 311245 84351 309295 305549 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223387 Thyroxine biosynthesis 25430 308129 302899 65162 266807 116700 114613 311374 29475 25653 79107 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-RNO-446199.1 Synthesis of dolichyl-phosphate 288525 294400 305291 81726 298541 311847 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%10222767 Class B 2 (Secretin family receptors) 680149 25051 58979 24166 114117 81753 24400 56813 117064 64680 25321 25026 81667 25029 25024 60432 171519 361383 56820 64199 29555 498791 316137 79218 29446 24241 399475 116506 245986 24875 25040 58959 60449 81779 24695 294962 81648 24953 58965 58966 24769 29151 24476 24694 83579 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222501 PKA activation 84420 24244 81636 64508 293508 29699 302950 64532 25521 25289 25725 24679 29241 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade 299147 117281 315648 84353 113927 79257 501584 363193 312754 309179 103691373 24673 679110 24205 84027 24672 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%10222837 Toll Like Receptor 10 (TLR10) Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 100912032 305355 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion 81635 25367 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation 266607 171101 25253 302813 294075 25040 25608 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223605 Mitochondrial ABC transporters 362302 140669 302395 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-RNO-157858.1 Gap junction trafficking and regulation 497913 29584 50563 84403 25751 29586 79217 50564 363677 292994 83805 83800 116561 24392 54241 79128 140694 116563 315840 394266 266707 25655 266706 29585 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%10222535 Formation of apoptosome 116590 100360940 63879 690675 50689 78963 295961 58918 25309 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%10223597 Transcriptional regulation of white adipocyte differentiation 25664 84578 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-RNO-171319.1 Telomere Extension By Telomerase 306264 295052 301965 171121 309144 287432 290232 297758 297483 170944 499709 500054 114494 367645 691534 307798 362288 307861 287273 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%10223313 Apoptotic cleavage of cellular proteins 304822 316164 305884 116685 170538 367786 292994 84353 60371 307562 81818 83497 24205 64159 25402 25614 298534 291755 64026 83502 25318 306871 361092 24170 296654 317589 64044 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%10223959 Acetylcholine binding and downstream events 25753 25302 54240 25590 81721 65024 79557 25103 170945 29422 54239 171131 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223097 FGFR1b ligand binding and activation 83823 29610 79114 25443 54250 25317 170579 170633 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-RNO-2559582.1 Senescence-Associated Secretory Phenotype (SASP) 680498 116590 365877 295052 501560 114483 690795 50522 310678 305420 361831 366381 302783 292588 24829 24828 293155 192255 114494 117056 100912032 685909 680615 360643 24253 303175 25164 83571 64627 50689 64156 494444 306970 94201 296368 81771 117269 361389 306945 288671 290875 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization 65158 81754 498266 25515 116590 50689 64528 RHOBTB1 GTPASE CYCLE%REACTOME%R-RNO-9013422.1 RHOBTB1 GTPase cycle 365407 117039 301555 360915 308968 117259 299809 25537 297406 81818 313216 140922 171115 315840 302855 261736 309722 361813 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors 292661 63889 309212 114098 114099 767613 84023 25652 498475 170926 81752 25637 24816 24929 59264 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%10224607 Regulation of FZD by ubiquitination 317674 313589 64156 499918 299802 64558 50522 282581 500863 498997 498233 303412 192255 100912032 364754 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 96%10225417 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 64156 50522 448830 246294 364867 252961 363328 60350 29260 362788 192255 299827 100912032 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) 117281 501582 100125373 83789 287522 365215 291434 259170 81729 25347 28298 307503 64205 26962 94266 24420 100910714 287596 64298 287113 290641 691397 298385 361923 134480579 117042 689116 287122 499782 117104 298075 360855 140661 140662 295284 29257 25348 300079 292964 81775 313449 293418 81776 81773 81768 81774 100361974 684558 65136 362631 691531 27139 294282 360572 122799 245981 29236 681429 497860 117053 81770 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 140654 81767 688288 81763 171350 29304 140655 29284 100361060 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 361109 361271 690303 24672 INTERLEUKIN-12 SIGNALING%REACTOME%R-RNO-9020591.1 Interleukin-12 signaling 85491 24514 84405 100361294 171334 171333 25506 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%10224549 Regulation by c-FLIP 306886 246756 64044 117279 266610 246097 25385 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%10224149 Reversible hydration of carbon dioxide 54233 54232 298657 54231 499566 29242 291819 302669 310218 363085 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 96%10223913 TRAF6-mediated induction of TAK1 complex within TLR4 complex 64156 362418 311245 50522 308267 317546 287545 448830 364867 363328 60350 29260 313121 192255 100912032 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 96%10222061 Neuronal System 25302 79211 66013 140675 25023 363447 171571 140729 25674 501560 84591 60422 140724 65187 170945 192258 24397 29695 29694 84016 171503 553106 25466 191573 25736 246153 83588 307234 64665 83764 360406 116563 315840 24418 24468 24414 266706 83633 50564 362979 66028 116470 25531 24803 29548 29547 116647 116724 29546 65040 171297 60391 286930 679668 685472 116681 78957 290467 50676 117096 317553 304733 300913 313052 116508 308571 116595 312855 309557 302473 309349 500219 294380 306147 59312 65046 140670 64053 24409 24408 24410 25400 24245 24246 24412 24411 29629 29628 29627 116695 83613 29495 50592 25252 171140 117284 58948 65180 65195 85426 366432 64199 60377 25550 286924 83506 24611 79218 25468 81636 246325 116745 245986 25327 84012 25469 294065 60449 295360 315435 24267 293508 114032 117023 302950 171011 65198 294962 66022 365241 64532 25521 170739 25686 24520 58981 25289 296395 259273 25643 29737 25725 60326 24679 171146 83579 29731 29241 307900 684516 27150 680149 84420 58979 24244 310519 306152 114117 24400 64508 29642 25050 81667 24681 29699 24680 79130 81664 60341 24957 29483 170567 29482 24904 25553 29503 25716 64830 24898 293645 116638 64832 79212 25558 25549 83612 140592 84556 79213 25012 29738 171163 25470 117018 84020 25743 170847 116649 83535 25560 50599 29713 29712 29718 25559 116560 25472 276720 308868 29613 54257 29559 64120 66016 29747 84390 294961 58942 59266 25297 83731 25398 84347 54262 54263 116600 50688 310303 306243 114244 300992 114245 140725 60355 29647 24379 81632 497009 24949 24380 83589 29179 60442 29130 29539 84429 59324 170899 688996 116489 445371 65272 116491 81646 24398 25529 29709 308495 29708 688721 25103 365222 29707 140945 29705 192268 29422 54239 171131 24947 81771 25753 54240 117269 25590 81721 79246 58963 65024 298521 81657 79557 24407 24406 25456 24922 59317 25451 25450 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%10221941 Processive synthesis on the lagging strand 59294 84490 85241 361698 25737 301323 59102 289758 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222379 RNA Polymerase III Transcription Initiation From Type 3 Promoter 690254 306012 304204 362537 306542 171068 83503 690966 301246 294687 498109 117526 114205 311487 310685 361102 685465 AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223477 Agmatine biosynthesis 298607 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB 83506 60341 24244 25050 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 96%10224141 Cross-presentation of particulate exogenous antigens (phagosomes) 79129 296456 66021 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts 303879 83569 83724 300790 170698 140668 58978 24186 502348 24777 29725 79111 25440 60351 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome 114764 117281 83836 299850 64462 311191 64158 311573 311802 311529 290626 300963 315423 83572 683722 29479 58822 363055 58945 305467 366403 367153 360672 308064 252921 293844 100362495 56010 316531 296554 310344 314787 60347 246150 29214 54237 299331 500069 29167 29213 81740 192228 307347 305882 294010 25515 29753 29489 24679 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 96%10224883 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 25203 313017 54237 25737 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 96%10222367 Formation of the Editosome 301226 498251 25383 170912 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%10224903 TP53 Regulates Transcription of Cell Death Genes 25533 64314 24484 58983 308986 134478826 140923 24942 293625 170824 300711 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%10224261 Degradation of DVL 287984 65138 94198 301555 29673 29671 29670 29677 29676 29675 50522 266772 81827 303251 83806 311078 192255 303811 100912032 83721 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 291209 303353 365388 117262 85492 NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance 24904 29539 308868 25553 29503 24898 24267 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 96%10222951 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 366381 292588 361389 293155 296368 310806 360643 288671 290875 64515 305420 361831 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10225019 Lipid particle organization 500292 290223 291541 311617 305150 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10221989 Regulation of TP53 Activity through Phosphorylation 290805 308755 497672 116549 140908 64557 363924 116671 303194 315969 64046 304798 85482 59102 192218 114212 58936 314862 685055 310034 313777 64156 306734 305000 65248 300711 297627 114592 64562 314621 360588 497856 64012 25520 311546 294800 83803 24842 373545 498411 295052 291787 81785 100361529 78975 50522 291773 317256 140583 170844 171152 309638 288533 685619 373541 293345 294018 192255 117526 288003 114494 287571 100912032 299694 288414 116468 81650 362272 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 96%10224761 Phospholipase C-mediated cascade; FGFR3 29349 84489 25444 54250 25317 29369 29368 60464 170583 25738 116499 60662 66017 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%10222615 Metabolism of serotonin 29539 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification 308755 497672 64557 24484 290997 290631 316794 298534 287927 297561 690914 497227 25573 309114 301442 499417 690043 296099 360748 308669 293719 289468 362827 362704 306257 363064 25094 307503 64041 29489 81655 50866 29564 252902 500545 304798 360860 140734 58945 304832 79257 29382 29417 29134 300837 308051 360990 24205 117282 117152 287362 312937 29640 79112 303923 316583 100910143 363109 297393 287159 305571 498272 364032 362275 297417 378774 498486 315807 360518 288041 293667 366478 302972 192263 81759 362756 501167 313536 300741 494342 302915 300089 65196 140639 24705 24919 58851 304157 81654 25154 304132 308384 60349 64154 289994 293456 64310 362162 361073 54350 309451 60355 65134 81613 297428 290994 300888 24946 246117 79120 304290 54400 58842 363136 690252 171121 192243 299850 310411 24648 300743 64462 29243 100912115 500152 56042 252853 89868 140940 60384 290659 64351 65165 445442 300674 291990 25423 685144 299121 362237 306264 309010 140673 503165 246310 690961 361705 301012 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 79224 304978 116666 117513 100360302 94189 116635 29167 84428 79117 361207 252889 58817 93646 171154 314030 266712 295461 306608 294010 297337 362412 361577 299201 308282 295568 293561 500636 307029 292845 362862 500616 361368 362567 311202 362520 299841 493574 257647 114489 308390 140568 94168 304917 287876 84491 65158 25268 260320 363104 25373 292485 24259 296290 83476 140638 308807 303635 288038 289525 63878 680692 313954 89842 304334 25685 362182 89829 25285 24765 689404 367252 79210 25307 114031 29461 503164 25434 361676 25277 84595 363455 25700 360622 315111 338474 299521 286906 298683 79110 298296 60333 292905 29160 56646 25376 363445 293184 303878 116718 641452 81920 305581 361531 312703 288617 680424 64460 29534 24375 303539 94273 308757 432392 25478 360915 363287 287772 292766 64156 296368 29669 29668 64515 29425 100360846 117263 25581 114592 29666 54237 303353 365388 117262 85492 60351 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 24233 406161 29675 50522 361831 292588 81827 313216 83806 311078 192255 114494 287280 361765 100912032 140665 29189 24257 29611 316342 305348 304966 293453 365314 171133 261736 291339 292666 117039 24244 114122 116640 100364984 29142 59313 366061 500249 192152 309649 293154 81506 140808 303100 65271 362625 295319 362859 29582 299756 24842 81519 25591 29240 297893 29565 24890 362191 295394 307151 64646 24829 83789 24828 502125 89820 313038 309626 64202 680615 25227 310258 361925 311013 303730 25586 303631 114589 103689978 64627 78973 311169 83834 315222 690244 24800 415062 690251 353251 365619 54279 301164 310326 306970 691259 304794 362409 309659 307404 307992 363060 207113 681194 313488 117054 314180 300017 300653 315075 29144 360838 291132 24832 113910 306945 681033 296394 29561 362093 502017 116597 501403 60378 362133 83501 117522 84430 541462 362934 116658 365877 688673 59318 690037 50864 85471 312806 691120 25547 311530 60371 316642 116696 298071 117523 365984 303692 363103 25280 83477 117185 304860 301155 291325 300445 407765 363040 64442 64445 287920 29758 316033 114711 364901 83505 313139 290744 25197 362924 64550 24413 25747 313304 361100 691517 299957 50692 367846 63996 295543 313961 316400 303277 300772 691688 353304 83712 24873 291171 117287 313128 363269 361645 116643 293528 102551929 315133 290638 83826 501145 116698 300320 303310 287662 310375 83422 688041 25672 316164 83614 301555 84385 293967 81812 26295 362414 289257 305614 64159 314251 308458 116725 311245 309452 309295 500133 313121 362788 362491 298541 311847 293587 295051 288525 294400 291095 310935 299346 305291 25493 312688 54226 303024 83727 302502 361181 59107 56816 65044 292406 292325 306886 287899 102550196 313233 305470 363836 83627 362154 308440 308976 102554393 100137086 79214 299314 314300 315728 54281 361142 305253 499968 474348 291958 306664 64043 100362554 367384 360847 286971 307838 286976 315263 300027 29750 288923 313878 25236 310261 362760 287444 497619 171569 303755 498034 310207 304571 314644 288700 297757 25615 365793 64456 500032 689102 314655 64633 685758 170501 294809 364630 501854 315059 362539 313231 308787 315212 361886 300668 100360475 293004 362031 316091 288611 306549 362547 291212 120100673 362599 117103 310670 299799 100361647 307039 361412 363123 312566 315879 311952 311039 361332 116740 300474 302499 300475 287427 66015 24942 287709 94197 252916 84590 50645 361014 367073 246324 29448 81830 81754 25353 79434 315668 81756 304135 680465 84589 309678 266688 116510 288779 317580 25532 25531 29650 299075 292074 367915 171361 84379 25530 501550 116722 117273 100361517 83499 288455 296651 124323 302415 290864 50592 286761 288306 24255 361190 100361658 684097 140593 315723 25387 29545 25388 29591 313427 50554 361749 305895 50557 65137 310324 307200 25631 688466 363259 310960 303602 309035 100360606 304298 314457 316131 308896 313020 100362121 83529 84607 83532 311633 83531 499016 245974 302488 315405 291737 311204 266601 499807 290652 498559 313242 408217 363164 25737 316228 361381 362762 114558 688478 298012 315745 296084 29168 302288 115771 361495 317381 364050 85423 304150 360928 688913 310306 307905 494320 498560 315134 24577 252929 293494 296121 500572 498798 499801 362636 360853 81516 314453 297593 171565 84478 25671 171329 29357 311856 304017 24968 293705 288482 24967 304579 291983 29614 316440 311030 362258 311026 29560 360471 60331 363982 299156 24208 310632 292876 171058 363084 298576 360571 305853 315523 500088 56084 171122 315911 360763 503269 25490 81755 315639 85237 171111 367242 689377 302931 102553119 689197 361664 316976 24210 29403 25128 294429 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 298692 292311 311548 690512 689746 315214 360665 362415 24186 26962 287276 25649 25506 25728 54225 25081 60373 266670 362902 293418 24232 29237 25087 24825 24468 81726 293060 361187 192351 305268 353227 305351 301674 363284 500017 64624 500262 308999 64631 362081 310363 313743 362511 498959 100360914 25295 81716 503446 29468 308283 304920 293023 64525 287706 494223 499114 171043 288921 688993 313722 367785 58983 305792 292757 290692 361219 498005 360818 361907 687364 685860 309453 83619 303478 100909445 171152 362566 306750 293345 363790 24874 303336 311881 300950 689226 81807 683630 117537 361268 316614 303792 300724 300849 24498 117524 297592 316628 24827 313445 306129 366854 81816 313101 314432 309153 500587 170583 24367 100909827 25533 303743 29183 170818 361029 171102 29304 117044 64520 363273 363283 367308 63880 25498 287367 64345 29452 100359675 64621 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors 83422 25094 83614 690244 25573 301442 499417 367846 362827 300772 296099 64520 303310 INOSITOL TRANSPORTERS%REACTOME%R-RNO-429593.1 Inositol transporters 171147 252854 114507 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME%R-RNO-983170.1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 365527 295461 29468 24223 24974 680842 499400 24812 287275 297522 24988 414786 29144 24750 287276 64202 685144 58817 25617 93646 SIGNALING BY NOTCH3%REACTOME%R-RNO-9012852.1 Signaling by NOTCH3 500538 56761 291999 25313 81751 29650 64156 29146 50522 311332 289231 84010 24329 300802 192255 29192 100912032 292788 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224947 COPI-dependent Golgi-to-ER retrograde traffic 297428 300888 79120 304290 296750 140940 60384 290659 65165 300674 140673 503165 246310 84599 114023 84393 304978 79117 361207 252889 361577 140932 300158 316226 361308 363288 289168 171291 113886 293502 315740 85248 171041 360953 313254 353302 287624 294286 246209 303575 303659 314473 81754 289309 117548 117550 171549 64310 362162 314906 309523 289397 309451 60355 363059 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%10225111 Processing of SMDT1 688685 298203 307350 114766 171433 301418 353231 365567 64198 25344 364601 295462 287979 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 96%10224403 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 29277 25426 24296 286904 24297 503122 310848 290623 266674 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) 314380 289757 363251 497672 308669 64557 289468 259171 25019 290907 362827 363247 24829 362704 290997 64046 290631 316794 498749 85482 192218 361767 303175 287927 64627 361815 116725 300711 690043 296099 360748 306945 64012 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-73930.1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 79116 29240 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%10222413 Nervous system development 286908 58960 361364 502694 116590 498898 140908 84009 116671 78966 306790 316009 24680 25513 25738 25454 366508 300802 170911 60664 24511 84477 29192 85243 25453 116690 292788 85385 295378 29302 306636 287989 83709 66023 498416 686310 296456 316369 81751 114559 29376 361388 25676 312275 24338 29433 304109 314850 310192 83841 360546 312477 363875 313644 29491 685269 366492 289231 83800 24553 54241 246331 25525 140694 116563 79114 299331 24329 81687 81686 310207 25615 64465 25622 296789 308376 65208 313498 362572 312213 310630 361568 25418 309280 311384 170851 25415 25417 315711 361597 363517 29751 289392 361537 24716 25136 316539 116683 310643 84358 81650 79208 364686 171287 314641 94268 298528 312279 29210 361882 116549 81732 316639 116696 117523 24718 289820 266729 297518 306400 59312 25537 60629 65046 315615 116743 25311 171119 25416 299737 140670 81515 117273 81521 288669 50687 83805 171574 84393 24408 54319 24410 84027 360854 300955 81824 64373 54227 24605 289257 293621 305614 64159 306628 24586 314251 81504 25614 24525 25150 81822 81646 25751 313845 290905 83510 308458 29423 50689 362993 293508 24699 301252 29431 501203 287876 29432 84427 84357 CO-INHIBITION BY CTLA4%REACTOME%R-RNO-389513.1 Co-inhibition by CTLA4 299147 24185 25150 117281 315648 25233 25622 29414 81515 313050 83805 363193 312754 309179 25408 24673 56822 24672 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange 290805 308755 497672 293452 291787 64557 306734 689055 102551085 305000 303194 140583 300711 499966 64046 360588 497856 85482 64012 499870 192218 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-RNO-193692.1 Regulated proteolysis of p75NTR 81736 24596 81751 300802 29192 311245 292788 57027 289231 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223929 Activation of Ca-permeable Kainate Receptor 58948 553106 24244 298521 24407 24406 54257 29559 29495 25252 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-RNO-5624138.1 Trafficking of myristoylated proteins to the cilium 367714 363126 64664 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224173 Ca activated K+ channels 66016 29747 294961 83731 54262 54263 310303 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10224539 WNT ligand biogenesis and trafficking 84426 24881 361846 684097 114487 140584 291678 315294 288666 289883 287357 114850 316526 362065 303586 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%10222293 Synthesis of PA 294324 680971 288322 296048 296623 361467 362058 362039 691905 287366 29354 60666 29692 363159 681694 295631 170919 298579 29526 29359 290843 311821 25062 311341 305166 362702 296130 29653 25096 25097 84470 PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 96%10224349 Pre-NOTCH Processing in Golgi 56761 65165 406162 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation 301252 79245 29753 362809 299331 116643 171361 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane 287533 84018 64633 295674 500132 305935 25532 246237 282584 308584 367786 309419 289021 50557 360521 361659 65038 305482 171088 25513 497932 85238 366508 54259 170911 60664 312634 85243 116720 94197 305419 288762 298947 361632 114554 497931 116699 116723 80849 89812 314641 498331 64310 317296 365865 140607 OLEOYL-PHE METABOLISM%REACTOME%R-RNO-9673163.1 Oleoyl-phe metabolism 498226 G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 96%10224125 G0 and Early G1 100360427 81758 295052 362485 313048 114494 297893 680111 292787 361178 25255 305171 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%10222775 Insulin effects increased synthesis of Xylulose-5-Phosphate 64524 83688 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222799 TRIF (TICAM1)-mediated TLR4 signaling 315599 315994 117281 500900 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 60371 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 266610 306886 246240 64156 25622 50522 361831 192255 287280 361765 100912032 315648 81646 641452 50689 25742 81647 116725 314322 311245 309452 81920 309295 81771 293624 310877 287545 117269 246294 448830 500133 364867 363193 363520 252961 363328 291921 60350 64044 29260 313121 24673 362788 362491 299827 292892 287707 363855 25272 84351 24516 289014 24672 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%10222391 GRB2 events in EGFR signaling 29183 24525 313845 25433 25313 24605 24329 293621 24827 64022 59325 81504 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193368.1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 301517 498790 83569 83724 307092 192242 291283 79244 361266 171516 307096 364773 498789 25429 191574 65192 29725 25428 79111 25541 246211 60351 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-RNO-174430.1 Telomere C-strand synthesis initiation 85241 290232 297758 500054 307798 307861 301323 303238 294025 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System 79239 116667 315599 315994 500900 309157 315305 24434 114495 501560 116596 116554 360647 502902 362418 64171 300980 308267 50658 291861 317546 363247 81736 25493 312688 116663 64046 54226 309361 60587 303024 361677 266610 116690 306886 246240 296456 299314 24856 499069 296654 309014 361527 24440 450223 29662 25019 307039 287610 288375 287427 287709 94197 24691 29543 29748 25316 100361818 366962 50645 363577 499285 24674 25047 24675 361400 246324 29448 305311 84492 29153 246294 29489 683849 307833 25406 314336 50866 24153 103690254 288779 25531 362347 63849 29650 25052 252902 367915 171361 361697 84379 25095 290029 58945 81745 317676 310461 292072 81515 361929 117273 83805 306600 83782 311396 117284 310178 363024 84353 300678 313050 24932 24703 294329 81679 50654 25751 117152 113936 252929 302526 290257 300732 117514 282817 315435 58923 116484 24590 29665 301252 360557 290408 304987 287362 246244 312937 299827 304017 292892 311430 246280 100360623 294673 292073 299825 116689 691149 493810 25513 25738 309147 170911 29692 84477 85243 85385 25012 680127 288305 29433 83841 363875 84497 296554 299732 314787 29214 299331 81687 25290 299809 306998 361537 63865 684440 361689 24600 312562 140868 81613 24159 140914 54225 24944 54249 315272 24648 29364 29511 25423 308875 299121 308995 29385 29583 29340 291085 690945 292409 306761 114023 29337 29221 25407 292844 24934 25505 29684 25518 679787 25110 498888 78963 140656 24614 56611 29186 362638 54258 24479 301229 24232 94195 681544 362862 81503 293130 25103 24598 314615 25441 24699 287876 308163 84007 25528 24795 64314 301512 84491 81683 301005 301059 297932 298103 362329 309684 29757 289407 499099 29192 362802 368044 296981 295378 298451 299971 25524 170667 436582 297566 312488 117596 25087 94170 116664 366545 25373 292843 289231 292846 292485 296290 100362805 140694 690158 83730 293118 58940 300250 574531 24468 306332 367562 64035 81675 445269 64465 362029 25307 432363 246358 641452 94167 81920 24599 58857 64537 81732 24248 117553 259242 64630 289820 501072 65192 679934 361383 24917 24375 297518 315348 287772 24223 292766 64156 29669 25097 29668 113959 288669 66021 171574 29425 100360846 306871 65261 117263 25581 29666 303353 313024 365388 117262 100361814 85492 688730 29143 117538 304284 363127 287984 117542 312647 65138 56780 360854 259275 94198 500361 445415 499157 29673 58970 690906 58949 29671 317335 29670 306324 155012 29677 290923 24233 29676 406161 100125364 81824 29675 64185 64459 50522 303180 298566 680842 308632 24854 497195 361831 24237 291091 29687 365466 81641 58823 29205 81827 114091 474169 362634 360914 54227 25419 79129 306760 295703 414786 83806 65197 64023 287721 311078 64668 54243 498128 192255 498234 79126 64681 24750 117512 287280 29333 84397 690130 361765 79113 84398 312705 100912032 299606 100360919 304692 291854 308901 192262 25155 299928 290409 295279 304543 25734 289395 192177 313264 303861 289211 85274 25739 315648 302495 291755 140665 360618 500324 298792 363131 684322 298682 24974 266775 304988 288778 58826 499400 303542 293508 65052 192264 291948 363193 24257 24251 292537 24988 304966 29714 83462 24673 286928 60352 362966 361635 291339 79249 293753 292666 294568 25328 84586 288174 24672 367901 295706 365527 362045 499271 304822 25455 117281 302890 116590 450222 360445 24244 25308 170538 289318 81511 361422 291759 64527 501546 314843 100364984 690263 308666 298066 315916 362271 89824 682937 79130 362432 362431 24366 361467 363522 313837 24367 300857 29142 25046 29521 361378 59313 378947 170923 54245 246272 25741 83799 83781 362249 246250 311821 363463 113940 292804 29738 25060 25374 310864 24189 309649 25035 366988 25551 25151 25425 293154 81506 24191 305679 295347 24642 362859 83578 315085 24472 25622 29565 310678 302783 24829 24828 24888 291359 246116 117056 501570 363494 305355 680615 171337 25227 303175 25697 64627 315222 295214 24618 361171 296321 116547 306970 499925 353316 317468 499926 641632 310553 641636 305354 84431 641651 641650 24620 311567 246238 24941 81650 299567 171162 641644 84355 685161 100361909 310611 316519 306945 641652 641655 84387 641657 641656 498840 498659 311860 641658 680498 498658 301034 316010 314618 365877 305234 286995 613220 613223 613224 29175 286958 613225 296354 641627 311558 60371 50585 156767 83687 305842 170496 360509 641624 308873 291000 290856 83477 360640 307366 29681 362893 316033 315949 25096 50692 116967 116643 308869 313648 289032 300955 64189 25017 304859 63880 24605 293621 64159 81504 25614 24426 24525 81822 25150 81646 313845 50689 25742 171341 81647 116725 314322 311245 309452 309295 81771 293624 287545 29292 310877 448830 117269 500133 364867 252961 360426 363520 291921 29431 363328 64044 79209 60350 29260 300447 313121 362788 362491 287707 363855 29432 25272 84351 24516 58918 25319 24206 289014 24464 305549 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223465 Regulation of insulin secretion 680149 266607 83535 25051 58979 25559 114117 24400 81666 81667 59326 24680 81662 81664 24778 24239 25262 64199 25736 24654 246153 83588 307234 79218 245986 81678 60449 293508 85240 294962 25083 64532 25297 25398 25686 24175 116600 25289 113976 300992 295347 25679 83579 114024 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%10224057 N-glycan trimming and elongation in the cis-Golgi 140808 362625 295319 81519 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-RNO-174437.1 Removal of the Flap Intermediate from the C-strand 290805 59294 84490 290232 297758 500054 361698 307798 25737 307861 59102 289758 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%10223253 ERK MAPK targets 117281 315648 116590 501560 50689 300980 81771 117269 363193 116663 60587 24673 24672 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination 498265 362960 289777 499870 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%10225013 VLDL clearance 25292 54225 680551 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-RNO-4085377.1 SUMOylation of SUMOylation proteins 113975 292085 295692 117021 362335 366016 58958 362557 65274 362827 113929 297522 245922 81738 683983 53372 25497 499974 25573 301442 499417 294429 287830 291874 362281 RESPONSE TO METAL IONS%REACTOME%R-RNO-5660526.1 Response to metal ions 689415 117038 NEUREXINS AND NEUROLIGINS%REACTOME DATABASE ID RELEASE 96%10224893 Neurexins and neuroligins 58948 29647 29548 29547 116647 116724 29546 65040 171297 60391 286930 679668 685472 116681 78957 117096 304733 313052 116508 116595 309557 500219 294380 59312 64053 24418 29495 24414 59317 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693565.1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 311860 368002 29722 497672 308669 293719 64557 156826 289468 116554 50522 362827 24829 362704 306257 290997 64046 290631 502935 316794 192255 85482 100912032 192218 114212 303175 287927 65179 64627 25573 313539 361815 64156 116725 301442 301128 300711 690043 292172 296099 306945 64012 24842 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%10223869 RHO GTPases activate PAKs 25594 29431 64465 24244 288057 29433 29432 116670 304813 363875 293860 DEADENYLATION OF MRNA%REACTOME%R-RNO-429947.1 Deadenylation of mRNA 171350 688288 117045 360760 303831 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-RNO-72695.1 Formation of the ternary complex, and subsequently, the 43S complex 83789 292762 682390 298700 25348 691947 362952 81775 81776 299872 81773 81774 293427 299027 54318 65136 691531 296302 27139 288516 294282 122799 29236 681429 117053 100362640 161477 64156 292148 100361756 29288 29287 29286 94266 29285 299899 124323 140654 29304 140655 29284 300069 293484 103689992 122772 29258 POTASSIUM TRANSPORT CHANNELS%REACTOME DATABASE ID RELEASE 96%10224177 Potassium transport channels 29718 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 96%10224201 TWIK-related spinal cord K+ channel (TRESK) 445371 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-RNO-9758890.1 Transport of RCbl within the body 29216 24565 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223461 Peptide hormone biosynthesis 25204 29200 64549 25447 116700 83711 25329 25653 24504 25196 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-RNO-111367.1 SLBP independent Processing of Histone Pre-mRNAs 171365 100362099 680737 366468 681031 687711 689116 501688 298075 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-RNO-9933937.1 Formation of the canonical BAF (cBAF) complex 361925 301020 303518 293514 361825 368001 287876 299186 297867 361295 192352 361711 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%10223559 Nuclear Receptor transcription pathway 25672 24208 84385 81812 24890 25149 252917 25154 360896 117274 299210 83574 365744 24413 60349 25747 58839 50659 25735 252924 259241 58850 58853 293701 497991 24873 25664 24705 65035 100365683 685072 81808 79240 245980 83826 25682 58851 60351 54278 DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins 498659 641658 498658 286995 613220 362347 613223 613224 286958 25052 613225 641627 83687 641624 24932 308873 290856 24691 310553 641632 305354 641636 641651 641650 683849 641644 308163 641652 641655 641657 103690254 641656 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) 24244 170538 502902 360647 64171 308267 317546 81736 117553 25493 362432 309361 83477 307366 360640 303024 81745 287772 292766 29433 64156 29669 81515 29668 83805 29425 100360846 29337 117263 25581 29666 303353 365388 117262 85492 450223 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 361831 81827 24703 83806 311078 288375 24605 192255 293621 287280 361765 100912032 25155 24525 25150 29748 641452 100361818 24674 116725 24675 311245 361400 309452 282817 25441 309295 293508 29431 64044 313121 29432 84351 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223937 MAP3K8 (TPL2)-dependent MAPK1 3 activation 81736 309361 303024 192255 116596 64156 287280 361765 50522 100912032 84351 309295 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 24225 25738 25730 25054 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-RNO-1660517.1 Synthesis of PIPs at the late endosome membrane 65052 288762 361632 363131 307842 306490 309855 316457 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME DATABASE ID RELEASE 96%10222419 Global Genome Nucleotide Excision Repair (GG-NER) 117039 84389 288651 361580 304719 315523 502227 299112 294693 313098 291703 171525 304573 302502 59102 361181 310707 298098 287927 360915 25573 64156 301442 499417 362385 300772 24919 290027 25591 83614 363273 65137 50522 363283 100362121 291737 192255 288003 361698 25737 361381 100912032 288414 289758 298012 116468 296084 59294 89809 361925 287367 85423 690244 293494 116725 266713 287876 261736 300813 316440 362258 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%10224287 Sulfide oxidation to sulfate 83586 170943 292710 81805 691966 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-RNO-9933947.1 Formation of the non-canonical BAF (ncBAF) complex 361925 301020 293514 296732 301235 368001 292622 287876 361295 192352 83833 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%10225549 Regulation of GBP-mediated host defense 313017 304266 24649 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-RNO-202733.1 Cell surface interactions at the vascular wall 81613 140914 499271 54225 25528 58844 25651 25650 300519 83509 50719 29364 116689 81683 25513 25738 65037 309684 360918 54259 499099 170911 25268 24511 25027 85243 85385 29302 308995 362248 116726 29583 25390 296456 29476 89807 81515 50687 83805 360922 25518 89843 307811 360606 65200 25622 171577 301229 313050 296269 315509 64025 245962 24605 293621 100360919 25599 81504 24525 25150 84551 50567 313845 363930 83580 619374 29409 25544 300338 25246 84427 116479 25406 89805 80878 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-RNO-400451.1 Free fatty acids regulate insulin secretion 266607 85240 81662 113976 81666 114024 24654 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%10223549 Electric Transmission Across Gap Junctions 362979 50564 315435 266706 DEGRADATION OF GABA%REACTOME%R-RNO-916853.1 Degradation of GABA 81632 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 312213 25150 246331 314641 309280 29751 316639 289392 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-RNO-428559.1 Proton-coupled neutral amino acid transporters 155205 246235 ENOS ACTIVATION%REACTOME%R-RNO-203615.1 eNOS activation 170520 24185 24244 24600 29270 299331 64157 298184 80773 25514 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-RNO-8963889.1 Assembly of active LPL and LIPC lipase complexes 100361444 300027 24539 362850 315218 54281 25507 502970 116548 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-RNO-69202.1 Cyclin E associated events during G1 S transition 287984 65138 94198 294790 29673 84389 295052 29671 29414 29670 29677 29676 29675 50522 81827 83806 362485 311078 192255 114494 287280 308937 100912032 24185 25233 83571 287772 366275 292766 64156 94201 266713 29669 171102 29668 29425 100360846 499655 307585 117263 25581 29666 58919 303353 365388 117262 85492 24708 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%10222481 Post NMDA receptor activation events 83506 81646 24244 501560 25050 81771 293508 29699 171503 117269 60341 25521 25725 24679 CS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022870.1 CS-GAG biosynthesis 50568 25181 29139 84468 25393 114122 291577 291770 297554 500257 304322 302302 314694 316533 81651 286974 361450 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224813 MAP2K and MAPK activation 362045 58960 56011 116590 25387 29542 25388 315707 498576 24366 24703 24367 170851 24605 170577 293621 59322 29302 171337 24525 64363 50689 685269 83805 288924 114486 305679 295347 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 96%10224531 Regulation of TP53 Activity through Association with Co-factors 292064 24185 25233 686781 29414 171355 246334 362675 685474 305025 311575 24842 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 96%10225351 STAT3 nuclear events downstream of ALK signaling 25125 84578 297893 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10225097 RUNX1 regulates transcription of genes involved in interleukin signaling 50662 361391 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%10223237 AKT phosphorylates targets in the cytosol 24185 292887 25233 309361 83571 296988 29414 24855 58918 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 96%10222219 Insulin receptor signalling cascade 116590 25444 25443 54250 25622 29369 83504 29368 170583 25513 170582 246273 29516 60662 170911 361992 84477 170579 25022 85243 85385 66017 81504 29349 29348 84489 498416 313845 25233 29376 81745 361388 50689 24506 363131 170700 24505 25317 314850 289625 170633 65052 60464 25467 79114 116499 25114 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%10223033 Signaling by FGFR 499349 117281 116590 292778 25444 25443 288588 54250 360903 316123 689116 29369 83503 29368 298075 361365 690966 25513 117017 170583 170582 25738 363633 299236 498109 289561 499308 170911 366205 170579 85385 66017 366061 29349 29348 84489 361388 25317 64156 314850 170633 83805 79114 500985 316213 83823 29610 25622 305539 83504 50522 140931 296072 500409 500526 306141 362950 307810 29497 361655 24605 192255 60662 293621 25022 100912032 81504 24525 313845 50689 29578 170700 289625 114486 60464 64200 116499 24673 25114 64535 24672 SIGNALING BY EGFR%REACTOME%R-RNO-177929.1 Signaling by EGFR 500873 361120 64465 301512 25622 117277 56084 50522 315707 306141 25513 25738 24605 192255 293621 170911 294981 100912032 85385 81504 313474 59325 315829 29183 24525 117255 313845 81922 25433 25313 114559 361388 64156 116743 64022 498798 81921 83805 64019 24329 24827 312574 360820 311598 311030 500985 84357 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 292892 84353 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%10224387 MHC class II antigen presentation 29564 29175 252902 299850 365542 294273 25423 685144 299121 684529 140734 290644 287531 58945 361704 24984 65046 297596 116743 140670 171574 83800 25424 25425 84393 54241 287275 140694 116563 259221 29167 84428 58817 306332 93646 295461 294010 294269 316226 24981 361308 24986 297522 289168 293502 315740 85248 171041 25599 63865 50654 25751 25697 353302 287624 29448 29489 314473 29144 117550 171549 64310 314906 81655 287276 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223663 Association of TriC CCT with target proteins during biosynthesis 29374 363658 24818 299809 297406 288305 294864 170897 295230 ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells 24525 24605 293621 29434 DOWNSTREAM TCR SIGNALING%REACTOME%R-RNO-202424.1 Downstream TCR signaling 308267 81736 25493 25513 309361 83477 307366 303024 54259 170911 85243 81745 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 50557 29676 29675 294269 50522 300678 313050 24981 361831 25300 25710 24986 81827 24932 83806 311078 192255 287280 361765 100912032 641452 116725 311245 309295 313121 362491 84351 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222041 Alanine metabolism 81670 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%10225271 Class I peroxisomal membrane protein import 309532 116718 65183 64460 25270 83519 297570 305581 363516 84356 29534 29533 310682 311203 288584 282634 307170 PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling 497932 25466 301059 309361 246273 300177 361992 287155 84482 24855 24185 25233 29414 81745 287772 292766 64156 29669 29668 83805 29425 100360846 117263 25581 63879 29666 303353 365388 117262 302415 85492 287984 65138 94198 29673 29671 29670 309419 361749 308051 29677 50557 29676 29675 50522 313050 81827 83806 311078 296988 192255 100912032 315648 310306 291999 500572 363193 25467 309179 116499 432361 24673 64030 24827 25114 25489 24672 362045 360471 117281 116590 25444 25443 54250 29369 29368 170583 25513 170582 366508 29496 170911 60664 170579 84477 85243 66017 29349 29348 84489 25433 29376 25313 361388 298947 25317 314850 497931 363875 170633 29149 24553 312754 79114 24329 24446 299147 25622 498596 297893 24890 83504 25149 307151 294515 60427 313038 60662 29613 309626 81737 25267 25022 25266 59325 310258 29183 24629 303730 24628 170700 64022 289625 315136 60464 81650 314641 501403 116549 308875 83571 24506 24505 83712 292887 291171 295357 100362346 313048 26954 117535 117044 117043 290669 362834 56718 360776 64520 308869 310091 298514 64226 688041 297960 310614 361724 294924 315093 686412 81504 25150 81646 50689 315189 313558 59265 311245 294048 296648 116723 25660 89812 294235 25556 24225 363520 310131 79209 25408 64545 361696 79240 56822 25730 25054 58918 365865 140607 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224757 Lactose synthesis 24778 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding 29374 116549 24818 299809 297406 288305 24400 54296 294864 170897 60449 81667 295230 29481 81650 294962 64013 363658 83579 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%10224675 Phase 0 - rapid depolarisation 140729 116600 50688 24239 300992 140725 140728 140727 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 96%10223431 PRC2 methylates histones and DNA 680498 303175 688041 296653 365877 64627 691153 306970 681740 690795 310678 302783 24829 83712 24828 444984 313048 117056 306945 685909 680615 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events 292778 84389 288651 288588 361580 316123 689116 502227 294693 83503 311796 298075 361365 301119 690966 117017 305455 679203 291705 291703 363633 498109 289561 304832 64525 304758 300837 362479 303281 500715 683469 303132 81785 291773 114510 317256 83828 170844 81673 83830 362110 171152 309638 288533 373541 293345 294018 303918 117526 287571 363064 306261 293184 81807 266713 361531 266787 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222071 Branched-chain amino acid catabolism 63864 301384 361215 29603 29711 294972 81708 25244 140547 25014 64203 298942 24513 25618 29611 293779 361884 29592 312381 63938 311849 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-RNO-9619665.1 EGR2 and SOX10-mediated initiation of Schwann cell myelination 308376 SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 96%10225437 Signaling by TGFBR3 116510 29200 81810 83823 29610 29543 25387 25388 81751 54250 29591 289231 29263 300802 81809 81707 24504 29192 65205 292788 59086 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition 25594 114764 117281 83836 299850 64462 311191 303024 64158 311573 311802 311529 290626 300963 315423 83572 683722 29479 58822 363055 58945 305467 366403 367153 360672 64156 308064 252921 293844 100362495 56010 316531 296554 310344 314787 60347 246150 29214 54237 299331 500069 29167 29213 81740 192228 307347 305882 294010 25515 50522 116670 117103 85265 25203 192255 287280 361765 304813 100912032 306102 29753 246294 29489 24679 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223691 Activation of AMPA receptors 29629 29628 29627 50592 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190840.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 24392 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-RNO-444411.1 Rhesus glycoproteins mediate ammonium transport 310625 65207 293048 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-RNO-420499.1 Class C 3 (Metabotropic glutamate pheromone receptors) 24415 500101 83633 500091 689869 78979 170634 690448 24247 500089 100310876 81672 554302 60590 29407 78981 78980 78983 294394 78985 24418 680188 81657 24417 24419 24414 502757 24416 100270683 246219 RHOB GTPASE CYCLE%REACTOME%R-RNO-9013026.1 RHOB GTPase cycle 363031 306618 361882 287537 360500 120099896 310635 54308 311647 64373 78966 117020 171296 25513 64630 290396 503306 299012 314212 293024 29355 81679 307098 64665 29528 307459 306400 498130 140898 310074 361921 25537 83764 310621 64678 317598 309696 297383 78967 312113 29275 312108 83620 360942 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-RNO-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 116491 59324 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223239 Regulation of TP53 Degradation 360471 117281 64226 295052 282844 29414 50522 304798 192255 114494 100912032 114212 115771 24185 315648 25233 81745 315189 64156 296648 300711 310131 24673 54237 25405 56718 311575 24672 24842 282845 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions 25150 64563 315546 316369 310695 100359836 300955 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222073 Histidine catabolism 685999 29301 293871 89833 309150 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-RNO-5610785.1 GLI3 is processed to GLI3R by the proteasome 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 113927 81827 83806 311078 192255 287280 361765 100912032 287772 361769 292766 64156 29669 29668 140588 29425 293508 100360846 117263 25581 29666 303353 365388 117262 85492 84027 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223883 Interleukin-27 signaling 29144 25125 680609 290655 24514 100361294 365368 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222819 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 448830 500133 364867 363193 363520 363328 291921 60350 64044 29260 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 287984 65138 94198 29673 499342 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 287280 361765 100912032 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-RNO-8948216.1 Collagen chain trimerization 294279 25412 25654 685612 301012 84032 85490 315071 353303 499431 314981 312115 60379 25681 304021 SIGNALING BY RETINOIC ACID%REACTOME%R-RNO-5362517.1 Signaling by Retinoic Acid 266603 266686 308190 289950 298942 81654 24172 81530 89813 353252 117098 170635 500629 29563 313689 116676 498790 83574 297805 312495 307092 291283 361266 296849 171516 140868 311254 25061 307096 364773 498789 191574 24705 685072 685750 24188 360420 25682 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975956.1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 361923 134480579 117042 689116 287122 499782 298075 140661 140662 29257 25348 300079 292964 81775 293418 81776 81773 81768 81774 100361974 684558 362631 65136 691531 27139 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 81767 140654 81763 171350 29304 140655 29284 100361060 103689992 58927 122772 29258 689284 501582 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 83789 291434 81729 25347 28298 307503 64205 26962 94266 24420 100910714 64298 290641 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225393 Negative Regulation of CDH1 Gene Transcription 85489 680498 688041 365877 297893 500569 690795 310678 302783 24829 25705 24828 117056 685909 680615 290270 303175 64627 309757 306970 689820 83712 29382 313048 306945 81717 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%10225073 MET receptor recycling 24553 25532 361388 287942 360658 54245 50866 24446 79121 81504 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 96%10222557 Thrombin signalling through proteinase activated receptors (PARs) 680149 29636 58979 79218 116590 116498 25387 25388 50689 114117 24400 245986 60449 81666 83805 81667 81662 294962 83579 64199 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 96%10223303 Synthesis of very long-chain fatty acyl-CoAs 94340 117243 171410 300783 171402 680115 171400 301120 84013 191576 117182 25288 361895 498728 309449 113976 364134 114024 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224633 B-WICH complex positively regulates rRNA expression 306274 368002 680498 362728 83582 690450 83581 365877 690795 310678 83503 302783 690966 24829 24828 301246 498109 117526 117056 317399 685909 680615 303539 303175 64627 301164 306970 60571 65261 306817 287876 361784 360893 361420 306945 313245 84027 84486 680493 TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism 116682 29416 50567 66029 59113 311844 64206 56823 681319 315439 50719 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 96%10224533 Regulation of TP53 Activity through Acetylation 24185 25233 679713 310614 290744 114495 361724 29414 297893 116723 306571 89812 363292 83712 313048 364298 117535 361374 290669 362834 140607 315210 24842 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 96%10223951 Deposition of new CENPA-containing nucleosomes at the centromere 499873 298850 365877 363198 362548 65137 690795 307805 302783 24829 24828 681185 685909 680615 305270 689296 25498 316602 303175 64627 684439 306464 679342 306970 25448 83712 315164 313048 289150 361416 306945 308839 288272 689399 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport 24904 29503 29504 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224911 MET Receptor Activation 24553 311331 292770 29135 24446 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224379 YAP1- and WWTR1 (TAZ)-stimulated gene expression 304514 308582 301164 363014 TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling 24525 313845 58844 25622 89807 296269 25513 24605 293621 170911 84427 85243 89805 85385 81504 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%10225311 Estrogen-stimulated signaling through PRKCZ 24525 116590 81745 24605 293621 25522 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-RNO-445095.1 Interaction between L1 and Ankyrins 308458 289257 305614 64159 314251 50687 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%10224969 Interleukin-36 pathway 25466 362077 311783 171106 296541 499744 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-RNO-9855142.1 Cellular responses to mechanical stimuli 311860 680149 117281 58979 24244 114117 24400 81666 25026 117104 81667 81736 29699 25493 25029 81662 309361 66026 24511 29302 296456 81745 58966 305679 29597 56718 64226 56611 24697 363014 64199 25614 24185 315648 79218 24627 24600 315189 245986 296648 60449 309295 29156 293508 29154 294962 310131 25521 25725 84351 24679 83579 24672 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 96%10222085 Metabolism of lipids 84018 24470 682974 294324 29632 305291 298504 25146 64677 25511 24950 286936 140544 84013 360348 117182 288025 362434 316039 680971 114101 498741 288322 287115 296623 362058 85311 404280 287366 314075 25413 25756 60666 363159 25757 681694 170919 361433 313997 690610 290843 293711 361686 691478 305166 25573 63888 64828 683713 499417 50555 300129 116482 83626 310508 192259 296972 29216 64633 289456 25322 691018 362827 79243 116463 25426 116740 94197 84509 300147 500132 25532 287424 287425 24404 171088 85238 116700 309419 25329 50557 363024 294255 25287 171155 170670 85254 316737 300757 301525 362275 114097 499689 140547 294673 295417 113965 500961 117543 65038 24158 499210 65196 25513 24886 313339 286896 25527 301118 25526 246115 59103 362039 29224 309147 366508 691905 54259 29354 24913 170911 29692 60664 308309 85243 295631 298579 29526 29359 297694 29726 298947 497931 287454 362972 678749 29527 29328 84497 252900 29624 79242 81639 29277 171522 25086 299732 24296 24297 266682 252931 65030 25290 25682 363026 114089 29470 84578 305482 362809 312634 365755 302711 312947 315973 246074 498790 63865 171410 361401 311341 83512 289125 299270 296851 94199 171402 307092 171400 25116 310848 25117 170897 359725 291283 170465 361266 171516 140868 25288 25045 24186 361802 307096 303577 364773 291984 498789 191574 266604 361895 498728 29411 84575 309449 170570 64310 113976 26759 499174 54398 364134 314438 100363074 500651 304208 29510 114024 100270678 310849 24159 353229 94340 366065 117243 500624 25363 296188 300783 366697 619561 307855 64304 360833 100911581 680115 308589 301120 361213 191576 310667 301024 366984 500292 140940 290223 291541 29254 311617 305150 499570 300108 25598 64822 79131 25062 79223 362732 296130 681211 29653 80841 296128 314800 117099 24450 295458 367112 65984 366463 690163 25014 497932 312086 361992 84024 25524 89842 293620 170698 314553 58978 361676 308518 291075 503049 291211 293688 29637 25675 81726 619549 25541 298298 81727 85255 29540 29230 311849 308100 309262 50559 117278 114100 310645 83791 64191 81681 140910 78968 300095 89784 29580 79244 50681 84114 84470 29725 114209 113956 79238 306460 307170 360753 85239 84029 60418 65183 64461 363516 314304 83842 83522 501072 65192 171142 81747 24917 364629 116720 363521 362702 25097 25429 362360 298369 502348 24777 498331 259221 25428 296461 79111 25440 311129 246211 60351 303497 301517 303879 83569 83724 362782 309527 58970 300790 140668 192242 364298 305419 360618 288762 361632 363131 114554 307842 116699 309855 316457 80849 65052 310155 29189 293453 317296 302425 287380 293173 679520 24307 290623 266674 502969 366196 298423 289733 296048 313375 361467 286904 24306 299566 50671 503122 50549 362249 311821 25279 687008 114700 312689 291939 307428 287533 295674 301131 305935 246237 282584 308584 367786 80848 289021 360521 310663 114561 306490 60581 361659 296732 363494 114104 310773 29367 303729 89841 25227 360843 311013 29194 83537 303631 289687 94338 315222 24800 365619 310326 684536 362409 307404 84431 81650 24192 314641 116549 316642 365984 117185 407765 64442 64445 316033 364901 83505 81919 25747 80773 25096 58924 361694 287467 304474 291699 192260 313786 81925 24230 29680 24873 497991 25557 79122 64562 373545 78975 116568 29566 58962 116723 89812 360426 312382 24565 289014 24360 365865 140607 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance 25073 25081 314459 80848 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-RNO-512988.1 Interleukin-3, Interleukin-5 and GM-CSF signaling 25622 24918 25126 25704 171081 65038 116689 25513 25326 25746 116562 366508 116630 24514 54259 287942 170911 60664 84477 85243 54245 85385 25155 81504 25734 25150 313845 81515 84492 25578 500985 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225279 Negative regulation of NOTCH4 signaling 24185 406162 RHO GTPASES ACTIVATE CIT%REACTOME%R-RNO-5625900.1 RHO GTPases activate CIT 360849 308761 83620 29495 363875 64373 117273 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%10225043 RUNX1 regulates transcription of genes involved in differentiation of HSCs 287984 311860 65138 94198 171046 29673 84389 85471 29671 29670 29677 29676 362675 29675 50662 50522 315606 81827 83806 311078 192255 363014 100912032 25720 25172 287772 292766 64156 266713 29669 29668 361391 29425 100360846 311567 117263 313507 25581 29666 303353 365388 117262 85492 25159 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10224999 The role of GTSE1 in G2 M progression after G2 checkpoint 114764 287984 65138 94198 25515 29673 29671 29670 29677 29676 29675 50522 406168 81827 25203 83806 311078 192255 100912032 287772 300126 292766 64156 29669 29668 29425 100360846 301252 117263 25581 29666 54237 299331 303353 365388 117262 85492 24842 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells 24185 84482 25233 29414 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-RNO-1660661.1 Sphingolipid de novo biosynthesis 310849 353229 366065 500624 296188 366697 360618 58970 307855 360833 308589 361213 80773 310667 170897 366984 499174 312382 314438 24565 500651 304208 100270678 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines 287984 65138 94198 29673 29671 308652 29670 29677 29676 29675 81827 83806 311078 689588 25502 24314 24609 287772 292766 29669 29668 29425 100360846 117263 25581 29666 81640 303353 84596 365388 298607 117262 85492 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 96%10224181 Phase 4 - resting membrane potential 364241 116649 116491 156873 29712 276720 64120 64119 84429 59324 170899 688996 116489 445371 65272 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222461 GPCR downstream signalling 501560 25740 362477 308118 54226 25372 24511 59075 50678 24185 308776 309962 25233 29414 25320 81745 117273 83805 25387 25388 24179 25605 60337 379044 25593 500157 310327 78964 25723 25513 170911 60664 85385 114559 298947 497931 317598 140928 54248 81749 688705 287730 24816 81743 24938 29254 25107 25229 688605 689936 29385 29340 282832 116498 25340 554302 50672 25342 29141 60590 292409 81678 64042 53949 308408 305795 294394 246759 29397 24260 25111 292419 25323 81509 59264 63887 25569 297795 767613 25689 29363 54258 84348 64373 24232 305236 50577 289023 171551 24807 24806 24808 24929 81821 290493 140866 292794 100361138 117549 24247 316259 192223 317219 25570 81503 29256 498289 63885 362505 100360071 497196 100911796 64636 302619 299242 25666 117264 57305 81657 353250 60395 308163 84007 25679 117027 497978 57302 89810 100270683 360579 29581 306618 499913 66013 171056 365228 500608 306307 287537 25555 29238 287418 89808 81644 689869 84009 29595 120099896 81645 310635 29237 311647 192205 310999 29235 192206 78966 170634 307398 316009 117020 24221 29234 497932 309653 84475 29471 303634 301334 171044 295449 29516 360918 309207 363460 293024 314386 100362710 362648 24797 25262 295378 298404 24677 25524 310460 307098 246174 114098 114099 363509 81672 25087 140898 361921 304109 310192 294807 25652 687105 29491 24323 24326 24448 81668 29335 301086 690158 24418 24659 266997 24417 24419 24772 114105 24414 60628 24416 25504 24415 309212 25187 64465 83633 500091 171371 497942 192648 363143 192649 29481 246358 116637 25637 25516 408199 25194 310444 25075 192646 501177 500089 100310876 301066 679957 287910 298006 29407 78981 78980 78983 362454 78985 498335 366270 366274 29538 117029 245920 83518 24889 246219 266607 406163 29480 60665 54289 29413 54294 29412 54293 78976 54292 25298 54297 679975 54296 54305 498246 301088 78979 302378 84583 25706 100361166 365901 59293 170926 84022 259224 114705 259222 246254 24613 362021 25380 289076 25264 24174 690448 25265 363682 29180 288995 378939 691774 116677 29636 64803 24182 25033 29191 24180 287673 499194 113959 24717 25245 63843 25248 170704 24953 25007 260319 680188 58812 24604 502757 171104 171108 500101 83567 310869 29290 171101 58949 64199 24654 286924 83506 24611 315648 79218 360616 24627 24626 25638 81636 245986 25238 24668 60449 25031 293508 302950 85240 363193 294962 64532 25521 25686 24673 25289 25643 25601 25725 24679 83579 29241 24672 367901 680149 84420 117281 58979 116590 140908 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 81662 81664 60341 29691 25433 25083 24175 24329 29597 114513 294075 59301 25537 81663 66025 306792 60399 116744 29415 500317 24605 293621 81504 24525 81646 313845 50689 81771 117269 29431 STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction 64362 24585 24583 24838 24837 300838 290561 58814 24852 81818 24851 500450 363925 29248 29389 29388 171409 56781 24907 171009 295929 295261 296369 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 96%10225159 Signaling by Erythropoietin 29376 361388 298947 24335 497931 81515 25513 366508 287942 24514 170911 85243 85385 81504 APOPTOTIC EXECUTION PHASE%REACTOME%R-RNO-75153.1 Apoptotic execution phase 304822 316164 305884 116685 170538 367786 292994 84353 60371 307562 81818 83497 24205 64159 24917 25402 25614 298534 291755 64026 83502 25318 498072 291145 680522 201097 306871 361092 84359 24170 684828 114114 24437 296654 317589 64044 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 96%10225233 Biosynthesis of DHA-derived sulfido conjugates 114097 499689 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225339 Formation of WDR5-containing histone-modifying complexes 314964 299569 360581 311468 26295 362414 309001 293488 310194 315606 360642 362224 316328 314704 100362634 303539 301164 304794 290829 310958 289881 100359816 293500 498112 300206 291440 362093 29417 102550344 313323 311575 207118 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME%R-RNO-2995383.1 Initiation of Nuclear Envelope (NE) Reformation 117281 114087 116685 25203 54237 25437 24917 117104 24672 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-RNO-5655862.1 Translesion synthesis by POLK 89809 64156 50522 316344 313702 309812 192255 288003 171525 25737 100912032 288414 59102 116468 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-RNO-9764560.1 Regulation of CDH1 Gene Transcription 85489 680498 688041 365877 297893 500569 690795 310678 302783 24829 25705 24828 117056 685909 680615 290270 303175 64627 309757 306970 689820 83712 29382 313048 306945 81717 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) 498265 290805 308755 497672 293452 64557 291787 689055 299112 102551085 50522 303194 140583 498119 499966 64046 192255 288003 361698 171525 304573 25737 85482 289777 100912032 287634 59102 288414 289758 192218 116468 59294 89809 293489 298098 64156 306734 305000 362385 300711 302982 316235 360588 497856 302953 64012 499870 293678 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-RNO-9029569.1 LXRs regulate gene expression linked to cholesterol transport and efflux 497941 84578 365755 302711 58851 313210 METHIONINE SALVAGE PATHWAY%REACTOME%R-RNO-1237112.1 Methionine salvage pathway 298934 305177 288912 298227 INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling 25326 25125 24918 25126 365769 METABOLISM OF PROTEINS%REACTOME%R-RNO-392499.1 Metabolism of proteins 308755 497672 64557 24484 290997 290631 316794 298534 287927 297561 690914 497227 25573 309114 301442 499417 690043 296099 360748 308669 293719 289468 362827 362704 306257 363064 25094 291671 307503 64041 94266 29489 81655 50866 29564 252902 353231 500545 304798 360860 140734 58945 304832 79257 29382 293408 29417 29134 300837 308051 360990 24205 117282 688685 117152 307350 116484 287362 312937 29640 79112 303923 316583 100910143 363109 297393 287159 305571 498272 364032 362275 297417 378774 498486 315807 360518 288041 293667 366478 302972 192263 81759 362756 113965 501167 313536 300741 494342 302915 300089 65196 140639 24705 81686 24919 58851 304157 289950 298942 81654 25154 304132 308384 60349 170897 64154 289994 293456 64310 362162 361073 54350 309451 60355 65134 81613 297428 290994 300888 24946 246117 79120 304290 54400 58842 363136 690252 171121 192243 299850 310411 24648 300743 64462 29243 100912115 500152 56042 252853 89868 140940 60384 290659 64351 65165 445442 300674 291990 25423 685144 299121 362237 306264 309010 140673 503165 246310 690961 361705 301012 24506 24505 64528 171049 309144 84599 683007 114023 29631 302470 287275 25407 79224 304978 116666 117513 100360302 94189 116635 29167 84428 79117 361207 252889 58817 93646 171154 314030 266712 295461 306608 294010 297337 362412 361577 299201 308282 295568 360975 293561 500636 307029 117099 24450 690163 292845 293655 362862 497902 500616 361368 362567 311202 362520 299841 493574 301458 257647 114489 24483 308390 140568 24482 94168 304917 287876 64539 293448 84491 65158 25268 260320 363104 25373 292485 24259 296290 83476 140638 308807 303635 288038 289525 63878 680692 313954 89842 304334 25685 362182 89829 25285 79438 24594 24765 689404 367252 79210 25307 114031 29461 25662 503164 292848 25434 361676 25277 84595 29481 680415 363455 25700 360622 315111 63868 338474 299521 25641 503049 286906 298683 79110 298296 60333 292905 29160 56646 25376 363445 293184 50559 303878 116718 641452 64526 81920 305581 361531 312703 288617 680424 64460 54296 314304 29534 299857 24375 303539 94273 308757 432392 25478 360915 363287 287772 79250 292766 297406 64156 296368 29669 29668 64515 29425 170587 100360846 24368 117263 25581 114592 29666 54237 303353 365388 114096 117262 85492 60351 287984 65138 94198 294790 29673 295052 29671 29670 29677 29676 24233 406161 29675 50522 361831 292588 81827 313216 83806 311078 192255 114494 287280 361765 100912032 140665 60449 29189 24257 294962 29611 316342 305348 304966 293453 365314 171133 261736 291339 292666 83579 117039 24244 24400 114122 116640 100364984 81667 29142 59313 366061 500249 192152 309649 302973 24773 29316 25369 246326 25425 245977 25548 25083 293154 25350 314799 310856 24175 170568 81506 140808 494021 50683 303100 65271 29300 362625 29597 295319 362859 29582 84395 299756 192155 24842 81519 25591 29240 297893 29565 24890 362191 295394 307151 365699 65155 64646 24829 83789 24391 24828 502125 89820 361338 313038 309626 64202 680615 25227 310258 361925 311013 303730 25586 303631 114589 103689978 64627 78973 311169 83834 315222 690244 24800 415062 690251 353251 365619 54279 301164 310326 306970 691259 304794 362409 309659 307404 307992 363060 207113 681194 313488 117054 314180 81650 266758 300017 300653 315075 29144 360838 291132 24832 113910 306945 681033 296394 29561 362093 502017 116597 501403 60378 362133 83501 117522 84430 541462 362934 116658 365877 116549 688673 59318 690037 50864 85471 312806 691120 25547 311530 60371 316642 116696 298071 117523 365984 303692 363103 25280 83477 117185 304860 83711 301155 294075 291325 300445 407765 24504 363040 25196 64442 301265 293142 64445 25608 306515 287920 25204 29758 29200 316033 114711 59301 364901 294698 83505 64549 313139 299903 290744 25197 362924 64550 24413 25747 313304 361100 691517 299957 50692 367846 63996 295543 313961 316400 303277 300772 691688 353304 83712 24873 685059 291171 361286 29447 117287 25604 313128 363269 361645 116643 293528 102551929 315133 290638 83826 501145 116698 300320 303310 287662 310375 83422 688041 25672 316164 83614 301555 84385 293967 81812 26295 362414 297376 298079 83474 170916 300786 289257 29539 305614 64159 314251 308458 116725 311245 309452 309295 500133 64013 313121 362788 363658 362491 298541 311847 293587 295051 288525 294400 291095 310935 299346 305291 309441 81829 25493 312688 54226 303024 25253 302813 83727 302502 361181 59107 56816 65044 292406 292325 306886 287899 102550196 313233 305470 363836 83627 362154 308440 308976 102554393 100137086 79214 299314 314300 315728 54281 361142 305253 499968 474348 291958 306664 64043 100362554 367384 360847 286971 307838 286976 315263 300027 29750 288923 313878 25236 310261 362760 287444 497619 171569 303755 498034 310207 304571 314644 288700 297757 25615 365793 64456 500032 689102 314655 64633 685758 170501 294809 364630 501854 315059 362539 313231 308787 315212 361886 300668 100360475 293004 362031 316091 288611 306549 362547 291212 120100673 362599 117103 310670 299799 100361647 307039 361412 363123 312566 315879 311952 311039 361332 116740 300474 302499 300475 287427 66015 24942 287709 94197 252916 84590 50645 361014 85253 367073 246324 29448 81830 81754 25353 79434 315668 81756 304135 680465 300338 84589 309678 266688 116510 288779 317580 25532 25531 29650 299075 292074 293725 367915 363241 171361 300033 292762 682390 84379 298700 25348 25530 691947 501550 362952 81775 81776 299872 81773 81774 293427 288599 303831 65136 691531 27139 288516 294282 122799 29236 681429 117053 100362640 161477 292148 100361756 116722 29288 117273 29287 100361517 29286 83499 288455 29285 296651 299899 124323 140654 171350 140655 29284 300069 293484 103689992 122772 29258 302415 290864 50592 286761 288306 24255 361190 100361658 684097 140593 315723 25387 29545 25388 29591 313427 116700 50554 361749 25329 305895 50557 65137 310324 307200 25631 688466 363259 310960 303602 309035 100360606 304298 314457 316131 308896 313020 100362121 83529 84607 83532 311633 83531 499016 245974 302488 315405 291737 311204 266601 499807 290652 498559 313242 408217 363164 25737 316228 361381 362762 114558 688478 298012 315745 296084 29168 302288 115771 361495 317381 364050 85423 304150 360928 113902 688913 24715 310306 302668 307905 494320 25627 498560 315134 113936 24577 252929 293494 302526 296121 290257 24179 500572 24310 498798 64017 499801 362636 266704 54242 360853 24590 81516 314453 297593 171565 84478 25671 171329 29357 311856 304017 24968 293705 288482 24967 304579 291983 29614 316440 311030 362258 311026 29560 360471 60331 363982 299156 24208 310632 292876 171058 363084 298576 360571 305853 315523 500088 56084 171122 315911 360763 503269 25490 81755 315639 85237 171111 367242 689377 302931 25176 102553119 689197 361664 316976 192234 299027 54318 117019 296302 64514 171145 24818 24210 64632 29403 288305 25128 294864 60627 295230 171455 116654 252881 50556 245709 294429 287830 291874 362281 29374 113975 292085 295692 305287 117021 299809 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 291434 298692 81729 292311 25347 311548 28298 690512 689746 315214 360665 64205 362415 24186 26962 100910714 64298 290641 287276 25649 25506 25728 54225 25081 60373 361923 134480579 117042 287122 499782 140661 266670 140662 29257 362902 300079 292964 293418 81768 100361974 362631 63864 360572 361755 245981 497860 81770 64640 81764 81765 81766 81767 81763 100361060 58927 689284 29215 29283 29282 25447 296709 64302 64306 100360439 64307 24232 134486107 25618 24399 25014 29237 361596 25087 24825 25653 24468 303746 295238 293054 309176 298517 291685 26203 26202 26201 26200 293754 297799 361883 690345 363023 311903 301552 299628 81726 497876 686234 26195 26194 26199 26198 26193 683519 26192 315141 288916 294230 309140 100363539 360594 500199 299938 292758 287962 25040 295224 296551 171061 292244 293060 363646 116650 361187 689432 312199 361473 108348073 287119 192351 361005 310653 362216 297601 56281 309440 305268 287656 297459 266607 315769 301250 301371 364656 353227 287302 293666 294754 305351 114017 301674 296134 64360 303685 363284 500017 113958 64624 294767 684304 308306 500262 680747 301352 290850 308999 297372 301240 498402 498406 64631 362081 310363 313743 362511 498959 100360914 25295 81716 503446 29468 308283 304920 293023 64525 287706 494223 499114 171043 288921 688993 313722 367785 58983 305792 292757 290692 361219 498005 360818 361907 687364 171101 685860 309453 83619 303478 100909445 171152 362566 306750 293345 363790 24874 94194 303336 311881 300950 689226 81807 683630 117537 361268 316614 303792 300724 300849 24498 117524 297592 316628 24827 313445 306129 366854 81816 289508 313101 314432 309153 500587 170583 24367 100909827 25533 303743 29183 170818 300677 94271 252934 26197 26196 641434 192241 171374 65262 361029 307270 171102 25557 29304 117044 117045 64520 116636 363273 363283 367308 63880 25498 287367 64345 29452 100359675 64621 24206 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-RNO-1855167.1 Synthesis of pyrophosphates in the cytosol 500709 306808 94267 50560 294292 688862 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223651 Amine ligand-binding receptors 25324 29581 25187 29413 29412 29238 25689 494319 29595 85268 81645 24473 65032 24318 24174 24925 294123 294124 25075 25229 25195 25645 294121 319107 113914 319105 53949 24448 302619 170704 25083 24175 24260 25111 25323 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%10223693 Glutamate binding, activation of AMPA receptors and synaptic plasticity 25023 363447 171571 140729 84591 140724 24681 84016 24680 65046 140670 25400 24245 24246 116563 84347 315840 29629 29628 29627 140725 29495 50592 59317 60355 25252 171140 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222227 SOS-mediated signalling 313845 25467 29376 81504 MAPK1 (ERK2) ACTIVATION%REACTOME%R-RNO-112411.1 MAPK1 (ERK2) activation 58960 24498 116590 25622 24514 100361294 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-RNO-9033241.1 Peroxisomal protein import 85239 84029 24792 680424 64461 64460 24248 685325 297570 314304 29534 83842 83522 501072 65192 171142 361413 64156 65030 266686 50522 24479 308518 308718 361831 291075 114027 25700 503049 311446 192255 117265 297029 303272 25541 100912032 85255 311849 363445 50559 116718 291922 641452 293067 64526 79244 81920 360463 305581 50681 84114 312703 84470 365571 29725 24599 114209 113956 79238 RUNX3 REGULATES P14-ARF%REACTOME%R-RNO-8951936.1 RUNX3 regulates p14-ARF 156726 363287 58919 361391 59086 RELAXIN RECEPTORS%REACTOME%R-RNO-444821.1 Relaxin receptors 295144 114215 25616 266997 294807 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 96%10225071 MET activates RAP1 and RAC1 171337 24553 313388 361388 287942 295347 363875 54245 24446 81504 SIGNALING BY PDGF%REACTOME%R-RNO-186797.1 Signaling by PDGF 66018 25622 300955 24918 25126 79429 25414 25513 25738 24605 287942 293621 445442 170911 25267 306628 85243 54245 25266 81504 292406 24525 24629 117255 24628 313845 316369 290905 25125 25676 85253 54281 83805 25692 25353 84427 SIGNALING BY ALK%REACTOME%R-RNO-201556.1 Signaling by ALK 25125 84578 297893 24924 266802 81517 25613 116689 25513 25326 25467 25738 170911 85243 85385 100910984 679566 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 96%10224441 SHC-related events triggered by IGF1R 24483 24482 313845 25718 85385 81504 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%10225065 Vitamin E transport 25571 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 96%10224347 Signaling by NOTCH 500538 304591 29650 29146 50522 300802 192255 65165 29192 100912032 292788 24185 56761 291999 304815 81751 25313 84006 64156 406162 311332 289231 84010 311567 25578 24329 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-RNO-5656169.1 Termination of translesion DNA synthesis 295704 299112 50522 316344 192255 298693 288003 361698 171525 304573 25737 100912032 59102 288414 289758 116468 59294 89809 298098 307905 64156 362385 300795 100147704 316235 DISINHIBITION OF SNARE FORMATION%REACTOME%R-RNO-114516.1 Disinhibition of SNARE formation 24680 25023 114095 81803 24681 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-RNO-6807047.1 Cholesterol biosynthesis via desmosterol (Bloch pathway) 309262 117278 114100 64191 293688 140910 298298 29540 DNA REPLICATION INITIATION%REACTOME%R-RNO-68952.1 DNA replication initiation 298098 85241 304573 299112 301323 362385 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-RNO-3270619.1 IRF3-mediated induction of type I IFN 299827 292892 499069 498840 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224265 Mitochondrial biogenesis 26196 171069 24399 24787 29754 362749 293615 641434 361596 690441 192241 171375 171374 65262 25309 306840 690675 245958 140608 300677 171082 94271 245965 26197 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins 316583 305571 685758 362275 170501 100360475 288611 120100673 100361647 311952 65196 311039 303692 116740 302499 363040 64442 366061 64445 65044 29758 292325 102550196 313233 83627 308440 690914 25197 497227 362924 79214 309114 361142 499968 291958 64043 367384 307838 286976 29750 313878 362760 290638 304571 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222295 Glycerophospholipid biosynthesis 294324 116549 298504 25511 286936 295417 140544 288025 362434 316039 680971 114101 498741 366196 288322 289733 296048 287115 361467 296623 362058 362039 85311 691905 287366 29354 314075 24913 60666 29692 363159 681694 308309 29254 295631 170919 361433 298579 313997 29526 29359 690610 297694 362249 290843 293711 361686 311821 25062 691478 363521 305166 362702 296130 29653 25096 362972 678749 25097 361694 84497 252900 287467 304474 192260 81925 192259 293620 296128 314553 363024 114561 361676 310773 29367 89841 360843 29194 361401 311341 294255 81650 171155 85254 360426 170670 84470 316737 302425 29510 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%10224101 ER Quality Control Compartment (ERQC) 192255 64156 50522 100912032 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%10224517 Postmitotic nuclear pore complex (NPC) reformation 113975 292085 295692 117021 362335 25573 366016 301442 362557 682908 297522 81738 683983 84509 287830 291874 NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway 301512 64314 114495 116725 311245 308267 309295 60371 317546 311567 500133 64044 313121 312937 362491 60352 58918 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway 114486 58960 116590 24703 170851 50689 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 96%10224611 SUMOylation of DNA methylation proteins 25573 301442 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-RNO-75953.1 RNA Polymerase II Transcription Initiation 292778 84389 288651 288588 361580 316123 502227 291773 294693 317256 83503 83828 170844 361365 81673 690966 83830 171152 117017 309638 288533 373541 291703 293345 363633 294018 498109 289561 303918 117526 287571 266713 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-RNO-418592.1 ADP signalling through P2Y purinoceptor 1 81662 25265 81666 83805 DNA REPAIR%REACTOME DATABASE ID RELEASE 96%10222001 DNA Repair 290805 308755 289757 363251 497672 293452 64557 156826 304719 116554 83508 363924 102551085 303194 315969 290907 363247 498119 499966 290997 64046 290631 502935 316794 498749 171366 171525 85482 302502 289777 287634 361181 192218 310707 114212 361767 293489 303193 298534 291905 287927 685055 310034 297561 25573 313539 361815 306734 301442 305000 499417 301128 300711 299638 302982 690043 360847 288079 297627 290232 292172 316235 297758 81528 296099 170841 360748 500054 360588 307798 497856 302953 307861 64012 499870 294800 293678 305957 367090 498265 368002 314380 29722 498411 308669 293719 291787 289468 259171 100361529 689055 25019 297486 140583 362827 84495 362704 306257 295704 366163 245976 313098 360915 64156 300795 100147704 313387 295052 497967 65137 50522 100362121 291737 192255 288003 114494 361698 363164 25737 361381 100912032 288414 289758 298012 116468 296084 59294 89809 246216 85423 307905 293494 84478 362394 261736 300813 316440 362258 360471 117039 81816 289508 315523 292101 140639 81685 65179 81709 314061 24919 24842 290027 362600 84490 25591 79116 83507 362479 29240 302783 24829 24828 685909 680615 680915 361925 303175 315344 64627 690244 306970 266713 306945 311860 365877 292778 84389 288651 288588 361580 502227 299112 292127 294693 690795 312641 83503 309256 100360594 361365 310745 690966 117017 291703 363633 498109 289561 304573 59102 298098 362385 300772 116643 306274 362412 83614 363273 362678 363283 314172 691105 316344 313702 309812 499155 298693 287367 501552 502320 303742 116725 287876 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%10224619 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 116561 54241 64512 317674 116563 362550 65046 140670 83800 306782 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-RNO-110314.1 Recognition of DNA damage by PCNA-containing replication complex 59294 89809 298098 362412 81816 64156 299112 50522 362385 313387 192255 288003 361698 304573 25737 363164 302502 100912032 288414 59102 361181 289758 116468 CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited 306886 246756 64044 117279 266610 246097 25385 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224081 Antigen processing: Ubiquitination & Proteasome degradation 303024 287155 56816 287927 363836 89829 308669 641452 81920 311373 293060 362277 361187 687633 315608 50558 192351 360534 316395 298689 317241 362294 315863 29274 305268 140939 303963 295252 316005 353227 314613 313525 305351 301674 303735 295704 363284 500017 64624 299197 498726 500262 117553 140941 308999 60383 306417 289437 64631 155812 64517 362081 310363 313743 362511 498959 100360914 503446 308283 302987 288596 304920 308968 293023 287772 292766 64525 64156 287706 494223 296368 685029 29669 362087 29668 64515 499114 29425 100360846 171043 619577 288921 361389 117263 688993 25581 313722 309591 367785 29666 363188 305792 303353 292757 365388 360926 117262 301515 316575 85492 290692 288671 683077 290875 282845 287984 312647 65138 361219 498005 94198 360818 294790 140593 361907 687364 29673 297930 302938 29671 685860 29670 309453 29677 690769 29676 171136 29675 500532 50522 303478 305420 100909445 361831 306505 366381 94196 292588 500511 81827 362566 83806 306750 303689 311078 296988 192255 363790 287280 361765 24874 652955 100912032 311866 360643 308901 303336 313264 297961 311881 301042 362900 300950 291597 689226 81807 117537 361268 316614 303792 300724 306825 300849 117524 300968 313115 297592 362367 316628 499877 300813 364681 25489 313445 192256 362377 362376 309758 362814 306129 366854 367167 81816 289508 313101 501546 314432 81815 171105 296161 500587 100909827 311567 361866 313806 301555 116725 690516 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%10224623 PINK1-PRKN Mediated Mitophagy 113894 64862 685620 363254 308416 50522 365601 300075 83529 83532 83531 299514 192255 266601 362245 192647 361321 100912032 56816 298575 363836 641452 64156 116725 81920 246294 299827 304017 B CELL ACTIVATION%REACTOME%R-RNO-983705.1 B Cell Activation 25023 24244 81736 116689 25493 25513 316241 309361 83477 366508 307366 303024 305584 25262 100913063 362046 499356 308501 287772 292766 64156 29669 81515 29668 81678 29425 100360846 29337 117263 25581 29666 303353 365388 117262 85492 25639 287984 65138 361618 94198 89821 29673 29671 29670 300955 29677 29676 29675 50522 29434 81827 83806 311078 24605 192255 293621 287280 361765 100912032 100360919 25155 81504 24525 29748 313845 100361818 24674 24675 294048 361400 309295 25679 84351 84357 367901 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%10224385 alpha-linolenic acid (ALA) metabolism 363516 50681 498728 83512 501072 84575 309449 171400 79244 25541 25288 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-RNO-212165.1 Epigenetic regulation of gene expression 140908 308911 302553 120095871 497941 102556967 368002 84578 310678 315606 302783 24829 24828 444984 100362634 361487 117056 365755 685909 302711 680615 303175 64627 301164 306970 304794 681740 300266 60571 366975 290829 100359816 306945 690559 246264 362093 100362170 102550344 311575 311860 680498 365877 689883 309001 690795 83503 690966 498109 317399 303539 290270 309757 83712 497991 65261 25664 619436 83516 310958 313048 289881 291567 361784 360893 300367 293500 108348224 361420 498112 300206 291440 116698 313323 29417 313245 24708 84486 207118 680493 84027 306030 306274 362728 314964 299569 83582 688041 296653 360581 690450 83724 299607 83581 287475 303403 299180 311468 26295 362414 293488 317343 310194 316209 360642 362224 316328 314704 85265 290939 299905 679693 301246 102546572 117526 100909569 691153 24522 680155 365192 306817 287876 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-RNO-198693.1 AKT phosphorylates targets in the nucleus 24185 84482 81646 294515 25233 361696 29414 79240 313558 302415 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-RNO-418038.1 Nucleotide-like (purinergic) receptors 171108 691774 317219 64803 29290 767613 302378 100911796 29316 25369 63843 117264 25265 29597 310444 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere 59294 290805 308755 84490 290232 297758 500054 361698 307798 25737 307861 59102 289758 BASE EXCISION REPAIR%REACTOME%R-RNO-73884.1 Base Excision Repair 290027 367090 362600 84490 25591 79116 365877 83507 29240 299112 690795 302783 84495 24829 24828 288003 361698 304573 25737 685909 59102 288414 680615 289758 116468 59294 89809 680915 298098 303175 315344 64627 306970 362385 290232 297758 81528 170841 500054 307798 306945 307861 305957 AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance 286908 58960 361364 502694 116590 498898 140908 84009 116671 78966 306790 316009 24680 25513 25738 25454 366508 300802 170911 60664 24511 84477 29192 85243 25453 116690 292788 85385 295378 29302 306636 287989 83709 66023 498416 686310 296456 316369 81751 114559 29376 361388 25676 312275 24338 29433 304109 314850 310192 83841 360546 312477 363875 313644 29491 685269 366492 289231 83800 24553 54241 246331 25525 140694 116563 79114 299331 24329 81687 81686 310207 25615 64465 25622 296789 65208 313498 362572 312213 310630 361568 25418 309280 311384 170851 25415 25417 315711 361597 363517 29751 289392 361537 24716 25136 316539 116683 310643 84358 81650 79208 364686 171287 314641 94268 298528 312279 29210 361882 116549 81732 316639 116696 117523 24718 289820 266729 297518 306400 59312 25537 60629 65046 315615 116743 25311 171119 25416 299737 140670 81515 117273 81521 288669 50687 83805 171574 84393 24408 54319 24410 84027 360854 300955 81824 64373 54227 24605 289257 293621 305614 64159 306628 24586 314251 81504 25614 24525 25150 81822 81646 25751 313845 290905 83510 308458 29423 50689 362993 293508 24699 301252 29431 501203 287876 29432 84427 84357 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes 81736 302553 304809 313539 301128 497941 363026 84578 297893 500569 310678 361402 315606 290925 64646 24829 83789 24828 444984 303518 502125 296732 89820 100362634 365755 310769 302711 680615 288563 361925 303175 100366024 64627 362831 295384 360531 103689969 60421 303514 299295 306970 289372 304794 360665 312440 498295 317464 83833 689820 306571 363292 317432 684297 102554884 84481 361825 54282 290829 304495 58919 689954 306764 100359816 361688 362825 306945 317425 297867 310352 688634 362093 363630 365155 102550344 311575 315210 303470 682469 680498 291844 301020 298595 83618 365877 679713 689883 296501 29520 308345 689582 309001 310638 290831 293668 314205 29512 29511 266670 364785 297597 299305 363481 362981 94201 83712 100362346 313048 117535 290669 362834 300206 64520 688041 83724 310614 361724 294924 26295 310194 360642 316328 298144 81647 309452 290284 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 59086 156726 287772 292766 64156 690516 29669 361391 29668 83805 29425 100360846 117263 25581 29666 303353 365388 117262 85492 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%10223735 Nitric oxide stimulates guanylate cyclase 140928 24600 54286 63885 24598 308899 191569 25523 171115 29691 24599 81743 25262 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 96%10225295 Transcriptional regulation of granulopoiesis 24705 24252 94201 HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state 84420 64508 113927 29699 287772 292766 64156 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 84027 287984 65138 94198 29673 29671 287612 29670 59320 29677 65209 29676 29675 50522 307724 308577 100362124 305349 303968 81827 295654 116475 312651 83806 503018 311078 362265 192255 287280 361765 100912032 304729 25273 289180 89830 361769 81636 140588 140589 293508 302950 311567 64532 25521 25289 25725 24679 29241 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade 116667 315599 315994 117281 500900 309157 116590 315305 114495 501560 116596 116554 362418 300980 308267 50658 291861 317546 81736 25493 312688 116663 54226 309361 60587 303024 680127 64156 50522 192255 287280 361765 100912032 315648 81646 50689 25742 81647 116725 314322 311245 309452 309295 81771 310877 117269 500133 363193 363520 291921 64044 300447 313121 24673 362491 287707 363855 25272 84351 24516 289014 305549 24672 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-RNO-170660.1 Adenylate cyclase activating pathway 302950 84420 24611 64532 25289 81636 64508 29241 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation 26196 301250 301371 364656 287302 293666 114017 296134 64360 303685 113958 294767 684304 680747 301352 290850 297372 301240 498406 303746 295238 293054 309176 298517 26203 26202 26201 26200 293754 297799 361883 363023 311903 301552 299628 497876 686234 26195 26194 26199 26198 26193 683519 26192 315141 288916 294230 309140 100363539 360594 500199 299938 292758 287962 295224 296551 171061 292244 363646 689432 361473 293453 361005 310653 362216 297601 56281 309440 287656 297459 26197 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%10222119 Phase I - Functionalization of compounds 308652 308445 24307 290623 266674 24894 24299 502969 298423 24886 24895 25527 25242 313375 25243 498999 498940 286904 24306 299566 503122 54246 171178 50549 25035 25279 80773 114700 25750 313786 29277 25429 171522 29680 25086 79122 24296 24297 266682 25428 252931 60351 301517 83724 362782 499353 308190 288517 24172 25426 298079 362809 266761 29539 25256 310201 246245 113902 57300 171451 100145871 312495 296259 25315 291084 310848 29473 25375 304078 310903 84493 29189 301252 24188 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222007 Carbohydrate metabolism 50568 25181 300993 404783 367166 24434 363513 291577 291770 297554 500257 304322 302302 314694 316533 691984 171517 116673 24771 317322 25236 678739 25216 29353 361377 140671 25615 367562 58920 690987 64035 81675 307091 309513 362029 303218 294449 302489 293451 292155 295430 84406 29633 363618 114002 364476 684979 108349781 299907 360670 117267 294103 295443 306866 25406 688293 64537 360630 368128 246136 295934 300757 301525 291015 303923 316583 24782 305571 84400 362275 84468 29139 293667 25592 24244 367145 307859 25393 294673 314771 114122 292073 64507 313536 500961 494342 299825 81682 58968 65196 24778 24377 361378 114508 25741 24651 362282 24334 25104 316265 315722 292804 25060 292138 310864 24189 296973 289608 54283 25634 25438 685076 24385 64152 66020 282821 303565 25694 100364027 24638 304885 315939 24959 294321 298690 266805 60416 498731 24191 24849 25059 294429 24640 24642 287830 25658 291874 29573 362281 117276 24362 113975 65152 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 25227 25697 313843 298003 24192 361730 684314 24188 24788 25659 363103 407765 363040 64442 64445 316033 366064 81919 296564 84597 362924 288161 100301568 29562 58924 501157 690945 287479 314140 83688 362383 64524 362706 24689 100360180 290277 171408 316067 246232 290638 24644 78959 500052 116721 81651 286974 361450 365583 297865 ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 96%10223155 Endogenous sterols 301517 83724 362782 313786 25429 29189 29680 25426 25242 79122 25243 498999 266761 25428 60351 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle 25558 25549 140592 84556 25012 116470 25531 24803 29647 24949 83589 29179 60442 29130 25716 64830 293645 64832 60377 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223851 Free fatty acid receptors 266607 365228 292794 TELOMERE MAINTENANCE%REACTOME%R-RNO-157579.1 Telomere Maintenance 290805 308755 364996 84490 295052 171121 287432 297483 170944 499709 288003 114494 367645 691534 361698 25737 362288 301323 287273 59102 288414 289758 116468 306264 59294 89809 85241 301965 309144 290232 297758 500054 307798 307861 303238 294025 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-RNO-8934903.1 Receptor Mediated Mitophagy 81650 64862 116549 363442 362245 360827 361321 365601 288731 83805 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9033807.1 ABO blood group biosynthesis 81919 100301568 58924 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 96%10225467 Regulation of MITF-M-dependent genes involved in pigmentation 50645 360034 361604 25017 DEATH RECEPTOR SIGNALING%REACTOME%R-RNO-73887.1 Death Receptor Signaling 306618 66013 500608 113894 287537 64314 287418 64639 84009 116554 120099896 310635 24835 25625 311647 308267 81859 310999 57027 687813 78966 317546 498803 307398 114210 81736 117020 364386 25493 309653 301059 303634 310738 301334 309361 295449 300802 363460 293024 100362710 287155 266610 29192 362648 246097 292788 25385 295378 298404 25402 310460 306886 307098 246756 246174 117089 363836 363509 81751 114559 117279 140898 361921 304109 310192 64547 687105 363875 29491 289231 100362554 114513 360827 94193 83537 29753 94338 641452 311401 308493 362828 81920 83765 317598 246294 450224 24596 360678 29409 362548 60371 60383 84006 64156 117273 63879 290864 50522 688466 361831 192255 100912032 115771 313845 83427 311245 309295 363520 64044 246244 312937 313121 362491 299827 84351 289014 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 286924 680149 58979 79218 64803 114117 24400 245986 60449 81667 294962 81664 25686 25643 83579 64199 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors 83422 25672 24208 83614 363287 84385 690244 25573 81812 24413 60349 25747 301442 24890 499417 362827 300772 24873 24705 25154 83826 58851 60351 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 96%10222913 Signaling by TGF-beta Receptor Complex 116590 313477 25490 81809 287155 24511 59086 81918 59107 29302 100360427 59106 292734 25717 24790 296456 311061 64156 83838 54281 680111 361178 117273 499929 362800 313757 25639 29417 500985 81810 25591 304758 29610 500715 29591 50554 24666 297893 25631 50522 361831 362110 192255 310655 100912032 25522 363445 84396 114208 50689 690516 81920 81516 29357 297699 300813 83837 116479 AUTOPHAGY%REACTOME%R-RNO-9612973.1 Autophagy 362045 113894 192647 56816 363836 300711 365191 64670 678769 313391 171415 300240 685620 24855 362164 363254 308416 316640 365601 288731 59319 305482 360682 300075 363278 686505 299514 308846 363442 362245 360827 689161 302559 312634 361321 305831 288498 298575 312927 499973 60445 641452 81920 246294 29489 282834 81650 312703 364419 363720 361916 58974 81655 287873 29564 679886 64862 303554 116549 252902 140734 58945 64156 65248 83805 295357 117287 64562 26954 117044 117043 56718 360776 25520 83803 308869 24255 310091 312647 298514 64226 373545 297960 78975 50522 83529 83532 83531 266601 192255 100912032 114558 363131 116725 65052 299827 304017 304579 TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels 89821 293874 116469 679906 362247 312896 83810 140933 292168 171143 171384 29465 114246 66026 60395 497948 361586 294329 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%10223591 Unfolded Protein Response (UPR) 54318 304962 498013 296302 314638 29702 303016 89842 299027 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%10224255 PI and PC transport between ER and Golgi membranes 114561 RHOC GTPASE CYCLE%REACTOME%R-RNO-9013106.1 RHOC GTPase cycle 363031 306618 361882 287537 300225 120099896 54308 311647 60431 78966 117020 25513 290396 299012 314212 293024 29355 293947 29681 81679 64665 29528 307459 306400 498130 140898 310074 25537 83764 25270 310621 64678 313618 117273 317598 309696 297383 360678 116666 78967 312108 83620 307170 65134 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-RNO-5218921.1 VEGFR2 mediated cell proliferation 24525 25023 81745 170538 25676 170897 83785 83805 25589 24680 25738 24605 293621 25522 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10225243 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 25290 29527 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%10224483 Ficolins bind to repetitive carbohydrate structures on the target cell surface 114091 64023 64459 GBP-MEDIATED HOST DEFENSE%REACTOME%R-RNO-9953170.1 GBP-mediated host defense 81822 171164 313017 81746 287876 25318 304266 54281 24649 362050 64511 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay 266605 679140 361736 307850 366017 500988 300045 297455 361399 498934 294975 360629 688288 171350 361109 293408 500305 363064 117045 364624 294595 360760 303831 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME DATABASE ID RELEASE 96%10225177 Noncanonical activation of NOTCH3 500538 56761 81751 300802 29192 292788 289231 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation 29349 84489 25444 25317 29369 29368 66017 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10225413 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 313648 81679 84430 29606 688673 116549 83502 78947 64701 293721 54281 84353 25507 362040 81650 266758 192275 314641 29144 100188932 300445 686092 293142 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 96%10225087 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 680498 365877 691504 297893 309001 50662 690795 310678 315606 302783 24829 24828 100362634 117056 685909 680615 303175 64627 295384 25172 60421 301164 306970 304794 361391 290829 100359816 306945 362093 102550344 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 287984 65138 94198 29673 295052 29671 29670 29677 29676 29675 50522 305420 361831 366381 292588 81827 293155 83806 362485 311078 192255 114494 360621 100912032 360643 287772 292766 64156 296368 29669 29668 29425 100360846 361389 117263 25581 29666 303353 365388 117262 85492 288671 290875 KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization 304822 291759 307562 300242 300247 300248 303519 680454 102553726 306871 450230 100364550 294853 450228 134481131 450227 690478 450229 100359886 300250 497995 369017 450225 100361571 407757 407758 266717 120095335 287701 287700 287702 680104 287697 287699 406227 287698 406226 406228 292848 25626 683313 680060 120093742 680703 291754 407762 102546758 134478810 302934 24332 315320 313672 102551497 310575 315324 294094 407760 60335 315323 499345 680152 308564 315318 292949 100363184 685544 682408 293619 360626 408235 360623 287675 287925 291760 303523 689230 303528 81679 287679 299587 303527 295190 291755 680071 309528 361319 100909661 307563 286912 GDP-FUCOSE BIOSYNTHESIS%REACTOME%R-RNO-6787639.1 GDP-fucose biosynthesis 291095 310935 311204 293587 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224305 HS-GAG degradation 688293 25697 64537 360630 25592 368128 363513 691984 171517 116673 24771 317322 25236 25216 25615 58920 HEME SIGNALING%REACTOME%R-RNO-9707616.1 Heme signaling 54225 448830 25081 29260 500336 24440 360504 304127 85252 361940 303333 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 96%10222147 GTP hydrolysis and joining of the 60S ribosomal subunit 361923 134480579 117042 287122 499782 308306 140661 140662 29257 25348 300079 292964 81775 293418 81776 81773 81768 81774 100361974 362631 65136 691531 27139 360572 294282 122799 245981 29236 497860 681429 81770 117053 100362640 64156 161477 64640 100361756 29288 81764 29287 29286 81765 29285 81766 124323 81767 140654 81763 29304 140655 29284 100361060 103689992 58927 122772 29258 689284 29283 29282 296709 64302 64306 100360439 64307 50522 134486107 83789 291434 81729 25347 28298 64205 26962 94266 100910714 64298 290641 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses 299827 292892 314336 499069 498840 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-RNO-190704.1 Oligomerization of connexins into connexons 29584 CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-1234174.1 Cellular response to hypoxia 287984 29560 65138 94198 29673 29671 29670 29677 29676 29675 50522 114490 361831 81827 25242 85265 83806 311078 192255 24874 100912032 641452 287772 292766 81807 64525 64156 316101 29669 64345 29668 29452 81920 54702 29425 308457 100360846 117263 25581 29666 303353 365388 117262 85492 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225187 RHOBTB2 GTPase cycle 81822 114612 300838 301555 117259 114562 299809 81634 297406 306004 360596 301252 140922 315840 302855 299331 361813 315265 DNA DAMAGE REVERSAL%REACTOME%R-RNO-73942.1 DNA Damage Reversal 303193 291905 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224435 Non-integrin membrane-ECM interactions 299940 500364 432360 305941 307548 362715 25724 25592 54250 170921 24680 24511 59086 29302 296456 691517 114489 116673 24771 303468 298936 497892 24907 25216 66027 309816 25615 25600 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%10225101 Invadopodia formation 57025 303068 679837 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%10224719 CD209 (DC-SIGN) signaling 24525 25150 29433 360647 81515 293508 81736 29431 24703 24605 288375 293621 29432 CELL CYCLE%REACTOME%R-RNO-1640170.1 Cell Cycle 290805 308755 364996 497672 362960 64557 363924 303194 292058 315969 307639 499914 290842 290997 64046 290631 303024 316794 85482 289777 305392 192218 680089 114212 362519 362438 298534 287927 685055 310034 25573 361815 306734 301442 305000 300711 690043 297627 290232 297758 296099 500054 360588 307798 497856 307861 64012 499870 294800 498265 60336 498411 307169 308669 684771 308870 291787 305343 289468 304218 100361529 290577 313861 117103 140583 362827 362704 24185 29753 25233 306464 679342 300126 287624 291441 685474 307947 257649 257644 64041 25448 94266 682908 246294 29489 307351 81754 363028 282834 291081 25576 25578 364419 500377 315164 307833 25577 304951 363720 361916 289150 361416 246118 363174 84509 500363 81655 303037 313478 307511 679312 287873 311575 363059 300218 114764 246772 29564 679886 286993 498736 114514 114087 298850 362700 83836 363198 362548 304477 29414 298594 170845 252902 85252 287101 113927 287598 307805 311191 29648 500545 102555739 295661 313017 304798 65201 681185 308443 296137 360860 317252 305270 83572 140734 58936 681050 58822 58945 684439 301965 81515 83805 65137 24514 288003 361698 25737 301323 288414 289758 116468 59294 89809 85241 301252 316737 287447 692032 680014 64158 691979 311573 309098 311802 311529 290626 300963 315423 171566 362203 683722 29479 363055 306599 305467 366403 367153 360672 308064 252921 308663 293844 100362495 316531 296554 287929 310344 680991 314787 60347 29214 500069 299331 362980 29213 81740 192228 294429 307347 287830 305882 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 361308 297522 245922 81738 315740 683983 53372 25497 499974 317425 171121 299850 64462 287432 297483 170944 499709 367645 691534 362288 287273 306264 64528 309144 29167 308839 288272 689399 499873 294010 361643 361088 308768 306102 290668 689296 171103 316602 361613 25023 406168 65158 498266 315508 300149 365191 25437 24917 363481 287772 292766 64156 296368 29669 29668 64515 29425 100360846 297176 361389 117263 25581 114592 29666 54237 303353 365388 64193 117262 85492 288671 290875 24708 287984 65138 94198 294790 361907 25515 116685 29673 295052 29671 29670 29677 29676 29675 116670 50522 310806 305420 361831 366381 292588 81827 293155 292263 500929 25203 83806 311078 192255 114494 287280 361765 304813 100912032 360643 315648 363193 309179 24673 24679 24672 25594 117281 116590 24680 312754 246150 311546 24842 299147 299204 84490 56011 64033 297893 24669 302783 24829 24828 25193 685909 680615 303175 64627 306970 266713 689820 81650 58919 306945 311860 365877 116549 84389 114483 399489 295596 299112 690795 312538 117104 305171 360908 316273 296178 81758 313479 682033 362485 291927 307126 360621 304573 292787 308937 59102 684111 29728 100360427 312046 298098 292071 25164 83571 301430 288532 366275 313138 313304 494444 680111 94201 171102 361178 63996 362385 56010 25255 499655 83712 307585 313048 84027 85265 25498 50689 116725 303238 294025 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-RNO-416550.1 Sema4D mediated inhibition of cell attachment and migration 306790 316009 24553 361568 306400 362993 363875 117273 MITOTIC PROPHASE%REACTOME%R-RNO-68875.1 Mitotic Prophase 25023 114087 365877 116590 690795 65158 24680 498266 315508 300149 362519 64528 54237 294429 287830 291874 362281 24708 113975 299204 292085 60336 25515 307169 295692 116685 117021 362335 308870 366016 58958 362557 65274 302783 113929 24829 24828 297522 245922 25203 81738 683983 53372 25497 685909 680615 499974 303175 64627 50689 25437 306970 307947 689820 81754 306945 317425 316737 287447 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%10225507 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 287984 362891 65138 373545 94198 29673 499342 29671 29670 29677 690315 29676 78975 29675 360967 50522 81827 83806 311078 192255 100912032 287772 292766 289874 64156 29669 65248 29668 29425 100360846 290823 117263 25581 407784 64562 29666 303353 116643 365388 117262 85492 25520 83803 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%10222223 Signaling by Receptor Tyrosine Kinases 499349 315994 25023 314910 315305 361120 114090 301512 300078 501560 117277 360903 300980 94203 83785 114110 114111 89811 25589 360457 116663 297932 298103 246273 60587 300802 29516 29757 289407 361992 287155 24511 29192 362802 368044 292788 296981 295378 298451 299971 29302 292406 83615 170667 436582 498416 297566 296456 312488 81751 117596 94170 114562 116664 366545 360406 54281 289231 83800 54241 116563 309816 500985 64465 140931 140583 24697 25414 25613 25700 29497 79121 24185 25233 366962 29578 85253 24924 266802 81517 84492 116548 25353 64200 311331 360658 303517 292770 361396 312574 311598 29135 50866 500873 66018 25532 29414 79429 64624 315761 679934 81745 315348 65046 64156 116743 140670 81515 117273 83805 66021 313024 117542 83823 29610 297930 84353 50522 313050 58823 79129 24514 192255 100912032 313474 315829 81679 315648 311163 25627 363131 296121 498798 293508 65052 363193 25467 116499 432361 24673 286928 60352 64030 24827 79249 25114 294568 25489 311030 24672 58960 117281 116590 362814 25444 25443 24244 54250 170538 170921 56084 314612 501099 29369 29368 308666 362271 315707 682937 24680 116689 170583 25513 25326 170582 59109 310738 25738 299236 499308 29496 366205 170911 60664 170579 84477 116478 85243 54245 85385 66017 366061 29349 29348 84489 117255 316369 25433 29376 25313 114559 25676 361388 25317 29433 314850 363875 170633 81527 362513 24553 310688 246331 79114 24329 299331 81687 295347 24446 100910984 679566 316213 303882 56011 84578 25622 498596 24918 305539 297893 25126 24890 83504 296072 50646 60427 25718 170851 287942 60662 29613 81737 361597 25267 294981 363014 25022 29622 25522 25266 59325 171337 29183 24629 24628 114203 315992 24600 170700 170897 64022 289625 25507 114486 311567 60464 364686 313388 292778 288588 316123 689116 83503 298075 361365 690966 117017 363633 498109 289561 445442 29340 25537 366275 24506 24505 691517 117535 56718 64226 360606 300955 117063 500409 500526 306141 362950 307810 361655 24605 293621 306628 81504 25614 24525 25150 81646 313845 290905 81922 25125 50689 298787 315189 296648 81921 81771 24483 25692 117269 64019 24482 24225 310131 29431 301737 363616 29432 84427 25730 360820 25054 289014 84357 64535 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%10222421 Nucleotide Excision Repair 360471 117039 292778 84389 288651 288588 361580 366163 304719 315523 502227 245976 299112 294693 83503 361365 690966 117017 313098 291703 363633 498109 289561 171525 304573 302502 59102 361181 310707 298098 287927 360915 25573 64156 301442 499417 362385 300772 314061 24919 290027 306274 25591 362479 83614 363273 497967 65137 50522 363283 84495 100362121 291737 192255 288003 361698 25737 361381 100912032 288414 289758 298012 116468 296084 59294 89809 361925 287367 246216 85423 690244 293494 116725 266713 362394 287876 261736 300813 316440 362258 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-390648.1 Muscarinic acetylcholine receptors 24260 25111 81645 25229 53949 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-RNO-391160.1 Signal regulatory protein family interactions 29364 25528 499537 155183 361537 50646 81504 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-RNO-5654693.1 FRS-mediated FGFR1 signaling 29349 24525 313845 25444 25443 54250 25622 25317 170700 314850 83504 29368 170633 170583 79114 116499 24605 60662 293621 170579 66017 81504 316213 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 96%10222577 G alpha (q) signalling events 379044 680149 360579 25593 29581 499913 500157 310327 58979 365228 78964 116590 25723 501560 170538 114117 24400 84009 29595 192205 81666 81667 192206 24221 24680 25513 308118 81662 54226 309207 170911 60664 314386 25262 114098 114099 25433 25087 310192 25652 24323 24326 24448 81668 301086 690158 24418 24659 24329 29597 24414 25504 25187 171371 192648 192649 25637 25194 287910 366270 366274 24889 266607 29480 29413 54289 29412 54294 78976 54293 54248 25298 498246 84583 302378 100361166 25706 81749 170926 59293 84022 25320 688705 25380 289076 25264 24816 25265 294075 24938 29254 25107 29180 25229 288995 378939 691774 59301 116677 29636 29340 116498 50672 25342 29191 24180 499194 81678 64042 53949 25245 308408 305795 294394 24953 25007 24260 260319 81509 59264 63887 83567 25569 767613 171101 58949 66025 116744 289023 500317 24807 24605 24806 293621 24808 81821 292794 140866 100361138 24247 64199 24654 81504 24525 192223 317219 81646 25570 79218 313845 50689 245986 25238 100360071 24179 497196 60449 25031 81771 85240 64636 117269 302619 294962 299242 25666 117264 57305 60395 25679 497978 83579 25605 367901 60337 PRE-MRNA SPLICING%REACTOME%R-RNO-72163.1 pre-mRNA splicing 24468 291794 288701 296320 362153 363005 114612 288718 500242 192246 308650 687711 363151 305479 140931 307410 171552 303057 498171 100362099 287768 29497 681031 299620 295270 294232 171365 295334 680737 501285 259170 29578 81781 298342 292810 64200 287113 100910202 314336 500790 500538 298385 305884 292778 361814 303346 288588 287530 316123 366163 287415 689116 245976 83503 297695 313588 298075 361365 690966 295284 117017 245957 302557 363633 498109 313450 289561 313449 686980 80846 313583 314313 361859 290614 313433 300361 292535 294711 293862 100361269 312474 303607 85434 60376 301432 361887 688288 498600 302855 289315 64510 89819 84486 300687 368070 117259 497967 361449 302969 494445 29667 294783 79256 292019 83624 362687 310687 319110 291295 117280 117282 246216 689890 362361 309651 84401 690585 680891 311855 367930 290284 362260 690303 362394 362152 679890 170933 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex 296178 313479 301430 291927 313138 360621 295596 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%10222513 CREB1 phosphorylation through the activation of Adenylate Cyclase 29699 25521 25725 24679 293508 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-RNO-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) 84429 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%10224555 Regulation of HSF1-mediated heat shock response 116590 59102 309757 294429 24468 287830 291874 362281 84027 113975 292085 79245 295692 24472 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 499974 25617 24963 29753 291671 60460 266759 116456 50689 307997 293103 362293 81800 500907 288444 297994 307133 311427 366734 293524 29734 690038 289014 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 59086 303539 156726 689844 310405 363287 679028 287772 303101 292766 64156 161452 29669 29668 83805 29425 100360846 117263 25581 29666 303353 365388 117262 85492 312451 24842 287984 65138 94198 29673 29671 50554 29670 29677 29676 29675 25631 84353 50522 81827 83806 308582 311078 192255 363014 100912032 301164 690516 361391 58919 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes 113894 84006 64156 311245 50522 301059 24596 363520 310738 362491 192255 100912032 84351 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 96%10222345 Beta oxidation of butanoyl-CoA to acetyl-CoA 64304 140547 113965 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224699 DAG1 core M1 glycosylations 114489 84430 688673 362567 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%10224629 RHO GTPases Activate NADPH Oxidases 292279 302976 25023 116590 170538 50689 363131 116547 363875 311793 66021 65052 24680 114243 79129 94195 25522 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%10223903 Mitochondrial tRNA aminoacylation 310856 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 96%10222203 The phototransduction cascade 680149 24244 24400 289878 688297 85259 291318 363143 29481 140936 499132 316218 116556 299521 81760 307401 317498 301233 64370 25539 59077 79222 64511 25318 24717 259274 83579 KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation 316033 84400 294673 314771 292073 64507 500961 299825 81682 58968 300757 301525 291015 PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%10223047 PI-3K cascade:FGFR1 29349 25444 25443 54250 361388 25622 25317 170700 314850 83504 29368 170633 25513 170583 79114 116499 60662 170911 170579 66017 81504 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 301517 498790 362782 307092 192242 291283 361266 171516 307096 364773 498789 191574 65192 79111 246211 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 96%10222645 Aflatoxin activation and detoxification 293653 94199 171341 171445 408206 116568 26760 295037 24894 24299 291984 24895 29566 24297 266682 252931 156275 300981 RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway 313689 498790 266603 116676 266686 297805 308190 312495 307092 291283 361266 171516 25061 24172 307096 364773 498789 191574 353252 685750 24188 360420 170635 500629 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D 287984 65138 94198 29673 29671 29670 29677 29676 29675 50522 81827 83806 311078 192255 100912032 287772 292766 64156 94201 29669 29668 29425 100360846 117263 25581 29666 58919 303353 365388 117262 85492 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223089 Intestinal hexose absorption 25552 65197